title: Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison.
abstract: Tumor-infiltrating plasmacytoid dendritic cells (pDCs) have been associated with poor patient prognosis. We have recently uncovered the ability of pDCs to activate and expand a subset of tumor-infiltrating FOXP3+regulatory T cells that express inducible costimulator (ICOS), providing new insights into the mechanisms that govern the escape of cancer from immunosurveillance.
authors.affiliation: Department of Dermatology; University Hospital CHUV; Lausanne, Switzerland.
authors.forename: Curdin
authors.initials: C
authors.lastname: Conrad
authors.forename: Michel
authors.initials: M
authors.lastname: Gilliet
keywords: ICOS; cancer; immunosuppression; plasmacytoid dendritic cells; regulatory T cells