title: Four flavanocoumarins from the leaves of Litsea coreana LEVL.
abstract: Two new flavanocoumarins, 1 and 2, together with phyllocoumarin (3) and epiphyllocoumarin (4), were isolated from the leaves of Litsea coreana LEVL. in Anhui Province, China. The structures of 1-4 were elucidated by spectroscopic methods. Biological tests revealed that 1-4 exhibited moderate anti-inflammatory activities through inhibition of TNF-α and IL-1 production in primary mouse peritoneal macrophages activated with lipopolysaccharides (LPS).
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei 230032, PR China.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Tang
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Zhang
authors.forename: Qing-Pin
authors.initials: QP
authors.lastname: Xiao
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Jin
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002396:Catechols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007375:Interleukin-1 / Q000378:metabolism; D032862:Litsea / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C585654:8-(3,4-dihydroxyphenyl)-9,10-dihydro-5,9-dihydroxy-2H,8H-pyrano(2,3-f)chromen-2-one; D000893:Anti-Inflammatory Agents; D002396:Catechols; D003374:Coumarins; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha