title: Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases.
abstract: Chemokines are members of the chemoattractant cytokine family. They play key roles in the trafficking of leukocytes and in the induction of chemotaxis through the activation of G protein-coupled receptor. Considerable interest has been paid to these molecules to elucidate their roles in the unique inflammatory responses elicited in the central nervous system (CNS). Chemokine CCL2 (also known as monocyte chemoattractant protein-1, MCP-1) is one of the vital chemokines that control the migration and infiltration of monocytes/macrophages. CCL2 and its receptor CCR2 have been shown to be induced and involved in various neurodegenerative disorders including Alzheimer's disease, multiple sclerosis, and ischemic brain injury. The present review will focus on the biological and pathophysiological aspects of CCL2 and CCR2 in the CNS and the possible therapeutic approaches for targeting these two proteins to combat neurodegenerative diseases.
authors.affiliation: College of Pharmacy, Dongguk University, Goyang, 410-820, Republic of Korea.
authors.forename: Shambhunath
authors.initials: S
authors.lastname: Bose
authors.forename: Jungsook
authors.initials: J
authors.lastname: Cho
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D002490:Central Nervous System / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D018932:Chemokine CCL2 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D018697:Nootropic Agents / Q000627:therapeutic use; D054390:Receptors, CCR2 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C111835:CCL2 protein, human; C515334:CCR2 protein, human; D018932:Chemokine CCL2; D009419:Nerve Tissue Proteins; D018697:Nootropic Agents; D054390:Receptors, CCR2