title: The impact of body weight management in chronic kidney disease patients with obesity.
abstract: OBJECTIVE
  Chronic kidney disease (CKD) and obesity are important public health concerns. Because obesity may initiate and/or accelerate kidney damage, weight control may benefit CKD patients.
  
  
  METHODS
  We examined the influence of dietary management and physical exercise in 38 obese CKD patients with or without target reduction of body weight 3% or more from baseline.
  
  
  RESULTS
  After a 2-month lifestyle intervention program, those with target body weight control had significant improvement of blood pressure control, as well as reduced lipid profiles, serum creatinine level (1.1 ± 0.3 vs. 0.8 ± 0.3; P < .001), estimated glomerular filtration rate (75.9 ± 21.2 vs. 104.9 ± 38.1; P < .001), and proteinuria (76.3% vs. 50.0%; P = .02). They had greater improvement in cardiorespiratory endurance in an 800-m running test (375.1 ± 64.7 vs. 327.1 ± 84.0 seconds; P = .001), better abdominal muscle strength and endurance in a timed sit-up test (13.6 ± 9.1 vs. 19.9 ± 9.2 number/minute; P = .005), and greater flexibility in a sit-and-reach test (18.8 ± 10.9 vs. 27.8 ± 10.9 cm; P < .001) comparing baseline and postintervention values.
  
  
  CONCLUSIONS
  A combination of dietary management and exercise were associated with improvements in health-related physical fitness, cardiovascular risk factors (blood pressure and lipid control), and renal profiles in obese CKD patients. Supportive individualized programs for lifestyle change could exert beneficial effects, but long-term research with a larger patient population is needed to elucidate the optimal effective combination of dietary management and exercise.
authors.affiliation: Department of Food and Nutrition, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Wang
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Shu
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Yang
authors.forename: Wen-Ching
authors.initials: WC
authors.lastname: Yang
authors.forename: Ming-Ju
authors.initials: MJ
authors.lastname: Wu
authors.forename: Tzu-Mei
authors.initials: TM
authors.lastname: Lin
authors.forename: Cheng-Hsu
authors.initials: CH
authors.lastname: Chen
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D003404:Creatinine / Q000097:blood; D004032:Diet; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008019:Life Style; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D011507:Proteinuria; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D013624:Taiwan; D055815:Young Adult
chemical_list: D008055:Lipids; D003404:Creatinine