title: Incidence of malignancies in cardiac allograft recipients - a single-center experience.
abstract: BACKGROUND
  Most of the available data suggest that the risk of malignancy in solid organ recipients is higher than in the general population. In Poland, the prevalence rate for malignancy in the general population is about 1.02%.
  
  
  METHODS
  At out Outpatient Clinic for patients after heart transplantation we analyzed all 324 patients transplanted from 1987-2011 for the presence of malignancies. The end-point of the analysis was determined by malignancy diagnosis, patient death, or end of the observation period (December 12, 2011).
  
  
  RESULTS
  We detected 31 malignancies in 29 of 324 patients (8.95%). In 2 patients we found 2 types of malignancies. The dominant type of malignancy was pulmonary carcinoma, diagnosed in 11/29 (37.93%) patients. Skin carcinoma was recognized in 7 patients (24.14%). Fourteen (48.3%) patients died (12 men and 2 women): 5 of them in the course of pulmonary carcinoma (35.7%), 3 of skin carcinoma (21.4), 3 in the course of lymphoma, 1 in the course of renal carcinoma, 1 in the course of stomach carcinoma, 1 of colorectal carcinoma, and 1 of prostatic carcinoma.
  
  
  CONCLUSIONS
  The risk of malignancy development is many times higher for HT patients than in the general population. The high incidence rate for pulmonary carcinoma in the analyzed group of patients was most likely related to smoking before transplantation and continuation of smoking after the procedure in the case of patients who received immunosuppressive therapy.
authors.affiliation: Heart Failure and Transplantology Department, Institute of Cardiology, Warsaw, Poland. m.sobieszczanska@ikard.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sobieszczańska-Małek
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Komuda
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Piotrowska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Korewicki
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Małek
authors.forename: Przemysław
authors.initials: P
authors.lastname: Leszek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zieliński
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology; D012907:Smoking / Q000009:adverse effects; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents