title: Balance is a key for happiness.
abstract: Eliminating one immunosuppressive mechanism is rarely sufficient to overcome cancer. One of reasons underlying this fact is that whether regulatory T cells (Tregs) or type II natural killer T (NKT) cells dominate immunosuppression depends on the mutual interactions between the latter and their type I counterparts. Thus, the balance among three immunomodulatory cell types dictates whether eliminating Tregs relieves or not immunosuppression.
authors.affiliation: Vaccine Branch; Center for Cancer Research; National Cancer Institute, NIH; Bethesda, MD USA.
authors.forename: Liat
authors.initials: L
authors.lastname: Izhak
authors.forename: Jay A
authors.initials: JA
authors.lastname: Berzofsky
authors.forename: Masaki
authors.initials: M
authors.lastname: Terabe
keywords: NKT cells; immune regulation; immunosuppression; regulatory T cells; tumor immunology