title: The multifaceted effects of omega-3 polyunsaturated Fatty acids on the hallmarks of cancer.
abstract: Omega-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, and docosahexaenoic acid have been shown to have multiple beneficial antitumour actions that affect the essential alterations that dictate malignant growth. In this review we explore the putative mechanisms of action of omega-3 polyunsaturated fatty acid in cancer protection in relation to self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion, and how these will hopefully translate from bench to bedside.
authors.affiliation: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK ; Department of Imaging, Leicester Royal Infirmary, Leicester LE1 5WW, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Stephenson
authors.forename: O
authors.initials: O
authors.lastname: Al-Taan
authors.forename: A
authors.initials: A
authors.lastname: Arshad
authors.forename: B
authors.initials: B
authors.lastname: Morgan
authors.forename: M S
authors.initials: MS
authors.lastname: Metcalfe
authors.forename: A R
authors.initials: AR
authors.lastname: Dennison