title: Bromodomain proteins in HIV infection.
abstract: Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biological studies defining the involvement of bromodomain proteins in the HIV life cycle. We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency.
authors.affiliation: Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Boehm
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Conrad
authors.forename: Melanie
authors.initials: M
authors.lastname: Ott
mesh_terms: D015967:Gene Expression Regulation, Viral; D006678:HIV / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D011487:Protein Conformation; D054730:Protein Interaction Domains and Motifs; D014764:Viral Proteins / Q000378:metabolism*; D016662:Virus Integration; D014779:Virus Replication
chemical_list: D009687:Nuclear Proteins; D014764:Viral Proteins