title: Use of raltegravir in a late presenter HIV-1 woman in advanced gestational age: case report and literature review.
abstract: Vertical transmission of human immunodeficiency virus (HIV) represents an important worldwide health problem and rapid decline in viral load is essential for HIV pregnant women to prevent mother to child transmission. Specific issues such as late presentation of pregnant HIV-infected women remain a clinical challenge. We present a case of an HIV-infected woman who presented to our hospital at 35 weeks of pregnancy, who was successfully treated with raltegravir-based first-line combined antiretroviral regimen. Even though there is limited information about safety and tolerability of the use of raltegravir in pregnancy, in our case this drug resulted in a rapid decline in HIV-RNA viral load, without side effects. The aim of the present study and literature review was to demonstrate that raltegravir can be a good treatment choice for very late presenting pregnant women.
authors.affiliation: School of Medicine, University of Genoa, at San Martino Hospital, Genoa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: De Hoffer
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Biagio
authors.forename: Bianca
authors.initials: B
authors.lastname: Bruzzone
authors.forename: Laura
authors.initials: L
authors.lastname: Sticchi
authors.forename: Roberta
authors.initials: R
authors.lastname: Prinapori
authors.forename: Daniela
authors.initials: D
authors.lastname: Gerbaldo
authors.forename: Cristina
authors.initials: C
authors.lastname: Gotta
authors.forename: Claudio
authors.initials: C
authors.lastname: Viscoli
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D057210:Delayed Diagnosis; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission; D019428:HIV Integrase Inhibitors / Q000627:therapeutic use*; D015497:HIV-1; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011263:Pregnancy Trimester, Third; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000068898:Raltegravir Potassium; D019562:Viral Load / Q000187:drug effects
chemical_list: D019428:HIV Integrase Inhibitors; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium