title: [Blood-brain barrier and blood-nerve barrier in neuroinflammatory diseases].
abstract: The blood-brain barrier (BBB) and blood-nerve barrier (BNB) restrict exchanges of soluble factors and cells between the blood and neural tissue, thus playing a crucial role in the maintenance of central (CNS) and peripheral nervous system (PNS) homeostasis. In neuroinflammatory diseases, disruption of the BBB/BNB is the initial key step in the development of inflammatory lesions. BBB/BNB breakdown during inflammation is related to two main processes: (1) leakage between opposing endothelial cells and alteration of junctional components, and (2) leukocyte extravasation into the CNS or PNS. The control of inflammatory cells and humoral factors such as cytokines at the level of BBB/BNB can develop a novel therapeutic strategy toward the inflammatory/autoimmune nervous system disorders.
authors.affiliation: Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Maeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanda
mesh_terms: D001812:Blood-Brain Barrier; D049428:Blood-Nerve Barrier; D002493:Central Nervous System Diseases / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007962:Leukocytes