title: Reduced burning and stinging associated with topical application of lactic acid 10% with strontium versus ammonium lactate 12%.
abstract: Burning and/or stinging is one of the most common concerns expressed by patients using topical therapies for treatment of dermatologic disorders. Topical lactic acid preparations often are used to treat dry scaly skin. In this study, we compared the level of burning/stinging reported by participants with application of lactic acid cream 10% containing strontium versus ammonium lactate lotion 12% and cetearyl alcohol lotion. The mean rating of burning/stinging reported for lactic acid cream 10% with strontium and cetearyl alcohol lotion was lower than ammonium lactate lotion 12% (P<.0001). Based on the study results, lactic acid cream 10% with strontium causes less burning/stinging than ammonium lactate lotion 12%.
authors.affiliation: Department of Dermatology, Mount Sinai Medical Center, New York, New York, USA.
authors.forename: Madelaine
authors.initials: M
authors.lastname: Haddican
authors.forename: Matthew
authors.initials: M
authors.lastname: Gagliotti
authors.forename: Mark
authors.initials: M
authors.lastname: Lebwohl
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D064753:Ammonium Hydroxide; D003879:Dermatologic Agents / Q000009:adverse effects*; D004338:Drug Combinations; D005233:Fatty Alcohols / Q000009:adverse effects; D005260:Female; D006801:Humans; D006878:Hydroxides / Q000009:adverse effects*; D019344:Lactic Acid / Q000009:adverse effects*; D008297:Male; D010146:Pain / Q000139:chemically induced*; D010147:Pain Measurement; D063465:Skin Cream / Q000009:adverse effects*; D013324:Strontium / Q000009:adverse effects*; D011795:Surveys and Questionnaires
chemical_list: D003879:Dermatologic Agents; D004338:Drug Combinations; D005233:Fatty Alcohols; D006878:Hydroxides; D019344:Lactic Acid; D064753:Ammonium Hydroxide; C419308:cetearyl alcohol; D013324:Strontium