title: Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population.
abstract: Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for pancreatic cancer (PC). We investigated the association of two single-nucleotide polymorphisms (SNPs) of the VDR gene with PC in age- and gender-matched patients and controls. PC (n=91) and healthy control (n=80) samples were genotyped for theFokI (rs2228570) andBsmI (rs1544410) polymorphisms using the PCR and restriction fragment length polymorphism (PCR-RFLP) method. Chi-square analysis was used to test for the overall association of VDR genotype with disease. There was a significant difference in the frequency of genotype FF between the PC patients and controls (Ptrend=0.009); however, the difference in frequency of genotype BB between the two groups was not significant (Ptrend=0.082). The difference between FF and Ff/ff frequency was significant (P=0.002). The two high-risk genotypes were ffbb and Ffbb, with an 11.66- and 6.42-fold increased risk of PC, respectively. VDR gene polymorphisms were important for the development of PC in this study population; however, further exploration of these findings and their implications are required.
authors.affiliation: Department of Gastroenterology, Shandong Provincial Hospital, Shandong University, Jinan 250021; ; Department of Internal Medicine, Taian City Central Hospital, Taian 271000, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Libo
authors.initials: L
authors.lastname: Yang
authors.forename: Guancheng
authors.initials: G
authors.lastname: Yin
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Shujing
authors.initials: S
authors.lastname: Sui
authors.forename: Jiyong
authors.initials: J
authors.lastname: Liu
keywords: BsmI; FokI; North China; pancreatic cancer; polymorphism; vitamin D receptor gene