title: Synthesis, structure and antifungal activity of thiophene-2,3-dicarboxaldehyde bis(thiosemicarbazone) and nickel(II), copper(II) and cadmium(II) complexes: unsymmetrical coordination mode of nickel complex.
abstract: The reaction of nickel(II), copper(II) chlorides and cadmium(II) chloride and bromide with thiophene-2,3-dicarboxaldehyde bis(thiosemicarbazone) (2,3BTSTCH2) leads to a series of new complexes: [Ni(2,3BTSTCH)]Cl, [Cu(2,3BTSTC)], [CdCl2(2,3BTSTCH2)] and [CdBr2(2,3BTSTCH2)]. The crystal structures of the ligand and of [Ni(2,3BTSTCH)]Cl complex have been determined. In this case, we remark an unusual non-symmetrical coordination mode for the two functional groups: one acting as a thione and the second as a deprotonated thiolate. All compounds have been tested for their antifungal activity against human pathogenic fungi: Candida albicans, Candida glabrata and Aspergillus fumigatus, the cadmium complexes exhibit the highest antifungal activity. Cytotoxicity was evaluated using two biological methods: human MRC5 cultured cells and brine shrimp Artemia salina bioassay.
authors.affiliation: Laboratoire SONAS EA 921, SFR QUASAV 4207, UNAM, Université d'Angers, Faculté de Pharmacie, 16 Boulevard Daviers, 49045 Angers cedex 01, France.
authors.forename: Kusaï
authors.initials: K
authors.lastname: Alomar
authors.forename: Anne
authors.initials: A
authors.lastname: Landreau
authors.forename: Magali
authors.initials: M
authors.lastname: Allain
authors.forename: Gilles
authors.initials: G
authors.lastname: Bouet
authors.forename: Gérald
authors.initials: G
authors.lastname: Larcher
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000254:growth & development; D019256:Cadmium Chloride / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D041221:Candida glabrata / Q000187:drug effects / Q000254:growth & development; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D056831:Coordination Complexes; D013882:Thiosemicarbazones; C022838:nickel chloride; D003300:Copper; D009532:Nickel; D019256:Cadmium Chloride; C029892:cupric chloride
keywords: Antifungal activity; Bis(thiosemicarbazone); Crystallography; Metal complexes; Thiophene