title: Photoassisted synthesis of enantiopure alkaloid mimics possessing unprecedented polyheterocyclic cores.
abstract: Enantiopure alkaloid mimics are synthesized via high yielding intramolecular cycloadditions of photogenerated azaxylylenes tethered to pyrroles, with further growth of molecular complexity via post-photochemical transformations of primary photoproducts. This expeditious access to structurally unprecedented polyheterocyclic cores is being developed in the context of diversity-oriented synthesis, as the modular design allows for rapid "pre-assembly" of diverse photoprecursors from simple building blocks/diversity inputs.
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, USA.
authors.forename: N N Bhuvan
authors.initials: NN
authors.lastname: Kumar
authors.forename: Olga A
authors.initials: OA
authors.lastname: Mukhina
authors.forename: Andrei G
authors.initials: AG
authors.lastname: Kutateladze
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D055668:Photochemical Processes; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D006571:Heterocyclic Compounds; D011108:Polymers