title: Pediatric Hodgkin's lymphoma: changing concepts and moving points in radiation therapy.
abstract: The classic treatment of Hodgkin's lymphoma (HL) in children resulted in significant late toxicity in long-term survivors. Late treatment effects included skeletal, cardio- pulmonary, gonadal toxicities, and second malignant tumor (SMN). This has driven pediatric HL groups to adopt treatment strategies using less intense chemotherapy, less alkylating agents, reduced radiation dose and volume, and omission of radiation therapy in selected group of patients. In limited disease, the aim is to maintain a high cure rate with minimal side effects. Patients with advanced-stage HL have a lower outcome, and need treatment intensification. Dose-dense, risk and response-adapted treatment strategies are evolving aiming at improving outcome and reducing toxicity.
authors.affiliation: Department of Radiation Oncology, King Faisal Specialist Hospital and Research Center, PO Box 3354, MBC34, Riyadh 11211, Saudi Arabia. Khafaga@kfshrc.edu.sa
authors.forename: Yasser M
authors.initials: YM
authors.lastname: Khafaga
authors.forename: Asim F
authors.initials: AF
authors.lastname: Belgaumi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D015996:Survival Rate; D017741:Survivors; D016896:Treatment Outcome