title: Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999-2011(1.).
abstract: Serotyping data for pneumococci causing invasive and noninvasive disease in 2008-2009 and 2010-2011 from >43 US centers were compared with data from preconjugate vaccine (1999-2000) and postconjugate vaccine (2004-2005) periods. Prevalence of 7-valent pneumococcal conjugate vaccine serotypes decreased from 64% of invasive and 50% of noninvasive isolates in 1999-2000 to 3.8% and 4.2%, respectively, in 2010-2011. Increases in serotype 19A stopped after introduction of 13-valent pneumococcal vaccine (PCV13) in 2010. Prevalences of other predominant serotypes included in or related to PCV13 (3, 6C, 7F) also remained similar for 2008-2009 and 2010-2011. The only major serotype that increased from 2008-2009 to 2010-2011 was nonvaccine serotype 35B. These data show that introduction of the 7-valent vaccine has dramatically decreased prevalence of its serotypes and that addition of serotypes in PCV13 could provide coverage of 39% of isolates that continue to cause disease.
authors.affiliation: Cleveland Clinic, Cleveland, Ohio 44195, USA. richtes@ccf.org
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Richter
authors.forename: Kristopher P
authors.initials: KP
authors.lastname: Heilmann
authors.forename: Cassie L
authors.initials: CL
authors.lastname: Dohrn
authors.forename: Fathollah
authors.initials: F
authors.lastname: Riahi
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Diekema
authors.forename: Gary V
authors.initials: GV
authors.lastname: Doern
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines; D015995:Prevalence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects / Q000276:immunology*; D014481:United States; D018074:Vaccines, Conjugate; D055815:Young Adult
chemical_list: C538862:13-valent pneumococcal vaccine; D000900:Anti-Bacterial Agents; D010406:Penicillins; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
keywords: Streptococcus pneumoniae; United States; bacteria; conjugate vaccines; pathogenesis; serotype; streptococci; vaccine