title: Granulomatous reaction within the thyroid metastases of a renal cell carcinoma.
abstract: Metastases of non-thyroid malignancies to the thyroid gland have been reported in 1.4% to 3% of patients undergoing thyroid surgery for thyroid malignancy. We report a case of thyroid metastases from renal cell carcinoma in a 57-year-old man, who underwent a left nephrectomy 11 years earlier for a renal cell carcinoma. The histological examination demonstrated a CD-10 positive and thyroglobulin and thyroid transcription factor-1 negative tissue, with numerous noncaseating gigantocellular granulomas. These findings are interesting for the possible role of the immune response in metastatic localizations.
authors.affiliation: 1Department of General Surgery, St Andrea University Hospital, Rome, Italy.
authors.forename: Francesco A
authors.initials: FA
authors.lastname: D'Angelo
authors.forename: Paolo
authors.initials: P
authors.lastname: Magistri
authors.forename: Laura
authors.initials: L
authors.lastname: Antolino
authors.forename: Fabio
authors.initials: F
authors.lastname: Socciarelli
mesh_terms: D002292:Carcinoma, Renal Cell / Q000556:secondary*; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000556:secondary*
keywords: granulomas; renal cell carcinoma; thyroid metastases; thyroidectomy