title: Design of chiral bifunctional quaternary phosphonium bromide catalysts possessing an amide moiety.
abstract: Novel bifunctional quaternary phosphonium bromides possessing an amide moiety were designed for the highly enantioselective sulfenylation and chlorination of β-ketoesters under base-free phase-transfer conditions. The tuning of an amide moiety of the catalyst was crucial to achieve high reactivity and enantioselectivity.
authors.affiliation: Laboratory of Synthetic Organic Chemistry, Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Shirakawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Tokuda
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Kasai
authors.forename: Keiji
authors.initials: K
authors.lastname: Maruoka