title: Mean platelet volume and its prognostic value in acute coronary syndrome complicated by cardiogenic shock.
abstract: BACKGROUND
  Elevated mean platelet volume (MPV) has been recently discussed as a predictor of death in patients with acute coronary syndrome (ACS), but the cut-off point of MPV in relation to poor prognosis has not been estimated so far. The aim of this study was to evaluate MPV and its prognostic value in ACS complicated by cardiogenic shock (CS). Such an analysis in patients with the most serious and fatal complication of ACS has not been performed inpreviously published research.
  
  
  METHODS
  Fifty three patients with ACS complicated by CS (age 68.9 ± 11.4, 49% women, 92% STEMI, 55% fatal CS) and 53 age- and gender-matched patients with uncomplicated ACS as a control group (age 69.1 ± 10.6, 49% women, 92% STEMI, 0% fatal) were included in our prospective study from 2010 to 2012. All the patients underwent successful primary percutaneous coronary intervention. MPV was determined on admission (MPV1) and in consecutive two days of hospitalization (MPV2, MPV3). The blood sample was analyzed immediately after collection in EDTA tubes using an automatic blood counter.
  
  
  RESULTS
  MPV1 was similar in both groups (8.91 ± 1.11 fl vs. 8.57 ± 0.74 fl, NS). Furthermore, there were no statistically significant differences in MPV value in fatal and nonfatal CS(8.90 ± 1.18 fl vs. 8.93 ± 1.05 fl, NS).
  
  
  CONCLUSIONS
  The above results suggest that MPV cannot be considered a predictor of poor in-hospital outcome in patients with ACS complicated by cardiogenic shock.
authors.affiliation: Intensive Cardiac Therapy Clinic, Medical University of Lodz, Poland. karolinaewa.k@gmail.com.
authors.forename: Karolina
authors.initials: K
authors.lastname: Supel
authors.forename: Agata
authors.initials: A
authors.lastname: Salska
authors.forename: Filip
authors.initials: F
authors.lastname: Jaskiewicz
authors.forename: Michal
authors.initials: M
authors.lastname: Kacprzak
authors.forename: Marzenna
authors.initials: M
authors.lastname: Zielinska
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012770:Shock, Cardiogenic / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome