title: Ins and outs of kinase DFG motifs.
abstract: In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known "gatekeeper" residue, regulate "in" versus "out" conformations of the conserved "DFG" motif. These findings suggest yet another role for the gatekeeper residue.
authors.affiliation: KINOMEscan Division of DiscoveRx Corporation, 11180 Roselle Street, Suite D, San Diego, CA, 92121, USA. dtreiber@discoverx.com
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Treiber
authors.forename: Neil P
authors.initials: NP
authors.lastname: Shah
mesh_terms: D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D020928:Mitogen-Activated Protein Kinases