title: Tailoring the magnetic and pharmacokinetic properties of iron oxide magnetic particle imaging tracers.
abstract: Magnetic particle imaging (MPI) is an attractive new modality for imaging distributions of iron oxide nanoparticle tracers in vivo. With exceptional contrast, high sensitivity, and good spatial resolution, MPI shows promise for clinical imaging in angiography and oncology. Critically, MPI requires high-quality iron oxide nanoparticle tracers with tailored magnetic and surface properties to achieve its full potential. In this review, we discuss optimizing iron oxide nanoparticles' physical, magnetic, and pharmacokinetic properties for MPI, highlighting results from our recent work in which we demonstrated tailored, biocompatible iron oxide nanoparticle tracers that provided two times better linear spatial resolution and five times better signal-to-noise ratio than Resovist.
authors.forename: Richard Mathew
authors.initials: RM
authors.lastname: Ferguson
authors.forename: Amit P
authors.initials: AP
authors.lastname: Khandhar
authors.forename: Hamed
authors.initials: H
authors.lastname: Arami
authors.forename: Loc
authors.initials: L
authors.lastname: Hua
authors.forename: Ondrej
authors.initials: O
authors.lastname: Hovorka
authors.forename: Kannan M
authors.initials: KM
authors.lastname: Krishnan
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D015195:Drug Design; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008657:Metabolic Clearance Rate; D057054:Molecular Imaging / Q000295:instrumentation* / Q000379:methods*; D009928:Organ Specificity; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles