title: Is JmjC oxygenase catalysis limited to demethylation?
abstract: Jobs on the side: Substrate selectivity studies indicate that members of the biomedically important JmjC demethylase family of histone N(ε)-methyllysine demethylases are capable of catalyzing the de-N-alkylation of groups other than N-methyl and can catalyze reactions that form stable hydroxylated products. The differences in binding preferences in this set of enzymes may be helpful in the design of selective inhibitors.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hopkinson
authors.forename: Louise J
authors.initials: LJ
authors.lastname: Walport
authors.forename: Martin
authors.initials: M
authors.lastname: Münzel
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Rose
authors.forename: Tristan J
authors.initials: TJ
authors.lastname: Smart
authors.forename: Akane
authors.initials: A
authors.lastname: Kawamura
authors.forename: Timothy D W
authors.initials: TD
authors.lastname: Claridge
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schofield
mesh_terms: D002384:Catalysis; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D056484:Jumonji Domain-Containing Histone Demethylases / Q000235:genetics / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D013379:Substrate Specificity
chemical_list: D006657:Histones; D056484:Jumonji Domain-Containing Histone Demethylases
keywords: demethylation; epigenetics; histone; hydroxylation; methyllysine