title: Severity of psychosis syndrome and change of metabolic abnormality in chronic schizophrenia patients: severe negative syndrome may be related to a distinct lipid pathophysiology.
abstract: BACKGROUND
  Metabolic abnormality is common among schizophrenia patients. Some metabolic traits were found associated with subgroups of schizophrenia patients.
  
  
  OBJECTIVE
  We examined a possible relationship between metabolic abnormality and psychosis profile in schizophrenia patients.
  
  
  METHODS
  Three hundred and seventy-two chronic schizophrenia patients treated with antipsychotics for more than 2 years were assessed with the Positive and Negative Syndrome Scale. A set of metabolic traits was measured at scheduled checkpoints between October 2004 and September 2006.
  
  
  RESULTS
  Multiple regressions adjusted for sex showed negative correlations between body mass index (BMI) and total score and all subscales; triglycerides (TG) was negatively correlated with total score and negative syndrome, while HDLC was positively correlated with negative syndrome. When sex interaction was concerned, total score was negatively correlated with BMI but not with others; negative syndrome was negatively correlated with BMI and positively with HDLC. No metabolic traits were correlated with positive syndrome or general psychopathology.
  
  
  CONCLUSIONS
  Loss of body weight is a serious health problem in schizophrenia patients with severe psychosis syndrome, especially the negative syndrome. Schizophrenia patients with severe negative syndrome may have a distinct lipid pathophysiology in comparison with those who were less severe in the domain.
authors.affiliation: Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan.
authors.forename: S-F
authors.initials: SF
authors.lastname: Chen
authors.affiliation: Yu-Li Veterans Hospital, Yu-Li Town, Hualian County, Taiwan.
authors.forename: T-M
authors.initials: TM
authors.lastname: Hu
authors.affiliation: Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan; Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: T-H
authors.initials: TH
authors.lastname: Lan
authors.affiliation: Faculty of Medicine, National Yang Ming University, Taipei, Taiwan; Chung Hwa University of Medical Technology, Tainan, Taiwan; Jianan Mental Hospital, Tainan, Taiwan.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Chiu
authors.affiliation: Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan. Electronic address: lysheen@ntu.edu.tw.
authors.forename: L-Y
authors.initials: LY
authors.lastname: Sheen
authors.affiliation: Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan; Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan. Electronic address: lohelwui@yahoo.com.tw.
authors.forename: E-W
authors.initials: EW
authors.lastname: Loh
mesh_terms: D000328:Adult; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000378:metabolism / Q000503:physiopathology*; D012559:Schizophrenia / Q000378:metabolism / Q000503:physiopathology*; D012720:Severity of Illness Index; D013577:Syndrome; D013624:Taiwan; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides
keywords: Glucose; Lipid; Metabolism; Psychosis; Schizophrenia