title: Assessment of atherosclerosis in obese adolescents: positive correlation of mean platelet volume and carotid intima media thickness.
abstract: OBJECTIVE
  This study aims to assess the correlation of mean platelet volume (MPV) and common carotid artery (CCA) thickness in a population of obese adolescents.
  
  
  METHODS
  Sixty-eight patients and 23 controls were enrolled. Anthropometric measurements, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase, hemoglobin, white blood cell count, platelet count, MPV and insulin resistance by homeostasis model of assessment of insulin resistance were investigated. Furthermore, CCA thickness was measured by high-resolution ultrasound.
  
  
  RESULTS
  MPV and the left CCA thickness were significantly higher in obese adolescents than the healthy controls. The association between MPV and left CCA was checked by linear regression analysis. MPV explained 19% of the variation in left CCA (P < 0.001). At multiple regression analysis, MPV maintained a positive association with the left CCA thickness (P = 0.002) independently of fatty liver grade, relative weight, total cholesterol and homeostasis model of assessment of insulin resistance.
  
  
  CONCLUSIONS
  MPV is significantly correlated with CCA thickness in obese adolescents.
authors.affiliation: Department of Pediatrics, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Nur
authors.initials: N
authors.lastname: Arslan
authors.affiliation: Department of Pediatrics, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Balahan
authors.initials: B
authors.lastname: Makay
authors.affiliation: Department of Pediatrics, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Şamil
authors.initials: Ş
authors.lastname: Hızlı
authors.affiliation: Department of Radiology, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Koçyiğit
authors.affiliation: Department of Pediatrics, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Demircioğlu
authors.affiliation: Department of Radiology, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Alpaslan Sedat
authors.initials: AS
authors.lastname: Tuncel
authors.affiliation: Department of Radiology, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Çakmakçı
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000175:diagnosis*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D009765:Obesity / Q000097:blood / Q000473:pathology; D014421:Turkey
keywords: carotid intima media thickness; childhood; mean platelet volume; non-alcoholic fatty liver disease; obesity