title: Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models.
abstract: Resina Draconis (RD) is a type of dragon's blood resin obtained from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China). It has been used as a medicine since ancient times by many cultures. The ethanolic extract of Resina Draconis (RDEE) was evaluated for its wound-healing activity using excision and incision wound models in rats. Group I, the control group, was treated with ointment base. Group II, which served as a reference standard, was treated with moist exposed burn ointment (MEBO). Group III was treated with RDEE. The parameters observed were percentage of wound contraction, epithelialization period, tensile strength, histopathological studies, microvessel density (MVD), and the expression of vascular endothelial growth factor (VEGF) and transforming growth factor- β 1 (TGF- β 1). The group treated with RDEE showed significantly better wound contraction and better skin-breaking strength as compared with the control group. The results of histopathological examination, MVD, and the expression levels of growth factors supported the outcome of the wound models as well. The present study provided a scientific rationale for the traditional use of RD in the management of wounds.
authors.affiliation: Department of General Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Liu
authors.forename: Shaohui
authors.initials: S
authors.lastname: Lin
authors.forename: Dan
authors.initials: D
authors.lastname: Xiao
authors.forename: Xiao
authors.initials: X
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Gu
authors.forename: Shanyu
authors.initials: S
authors.lastname: Guo