title: Obesity leads to higher risk of sperm DNA damage in infertile patients.
abstract: There has been a growing interest over the past few years in the impact of male nutrition on fertility. Infertility has been linked to male overweight or obesity, and conventional semen parameter values seem to be altered in case of high body mass index (BMI). A few studies assessing the impact of BMI on sperm DNA integrity have been published, but they did not lead to a strong consensus. Our objective was to explore further the relationship between sperm DNA integrity and BMI, through a 3-year multicentre study. Three hundred and thirty male partners in subfertile couples were included. Using the terminal uridine nick-end labelling (TUNEL) assay, we observed an increased rate of sperm DNA damage in obese men (odds ratio (95% confidence interval): 2.5 (1.2-5.1)).
authors.affiliation: AP-HP, Jean Verdier hospital, Reproductive Biology unit-CECOS, Bondy, France. charlotte.dupont@jvr.aphp.fr
authors.forename: Charlotte
authors.initials: C
authors.lastname: Dupont
authors.forename: Céline
authors.initials: C
authors.lastname: Faure
authors.forename: Nathalie
authors.initials: N
authors.lastname: Sermondade
authors.forename: Marouane
authors.initials: M
authors.lastname: Boubaya
authors.forename: Florence
authors.initials: F
authors.lastname: Eustache
authors.forename: Patrice
authors.initials: P
authors.lastname: Clément
authors.forename: Pascal
authors.initials: P
authors.lastname: Briot
authors.forename: Isabelle
authors.initials: I
authors.lastname: Berthaut
authors.forename: Vincent
authors.initials: V
authors.lastname: Levy
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cedrin-Durnerin
authors.forename: Brigitte
authors.initials: B
authors.lastname: Benzacken
authors.forename: Pascale
authors.initials: P
authors.lastname: Chavatte-Palmer
authors.forename: Rachel
authors.initials: R
authors.lastname: Levy
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004249:DNA Damage; D053938:DNA Fragmentation; D006801:Humans; D020287:In Situ Nick-End Labeling; D007248:Infertility, Male / Q000209:etiology / Q000235:genetics*; D008297:Male; D009765:Obesity / Q000150:complications / Q000235:genetics*; D050177:Overweight / Q000235:genetics; D055101:Semen Analysis