title: A complementary component to atypical haemolytic uraemic syndrome.
abstract: We describe a case of a 22-year-old man who presented with clinical features of atypical haemolytic uraemic syndrome and in whom genetic analysis of complement regulatory proteins demonstrated a CD46 mutation. He was treated with plasma exchange, intermittent haemodialysis and blood transfusions. At 6-month follow-up his haematological parameters and renal function showed complete resolution, and he experienced no further disease recurrence in the subsequent year.
authors.affiliation: Department of Nephrology, Royal Free Hospital NHS Trust, London, UK. vanita.gandhi@doctors.org.uk
authors.forename: Vanita
authors.initials: V
authors.lastname: Gandhi
authors.forename: Aine
authors.initials: A
authors.lastname: Burns
authors.forename: Timothy
authors.initials: T
authors.lastname: Goodship
mesh_terms: D000328:Adult; D065766:Atypical Hemolytic Uremic Syndrome; D003165:Complement System Proteins / Q000235:genetics*; D003937:Diagnosis, Differential; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D009154:Mutation; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D016756:Immunoglobulins, Intravenous; D003165:Complement System Proteins; D008775:Methylprednisolone