title: Comparative evaluation of short- and long-term treatment of periodontitis with alpha-lipoic acid.
abstract: The ultimate goal of research was to make a comparative evaluation of efficiency of periodontitis treatment with alpha-lipoic acid in the short-term and long-term period in people which are under the influence of heavy metal salts of low intensity. 50 patients residing on the territory under the influence of heavy metal salts of low intensity, were under observation and they were given medical treatment to evaluate the efficiency of periodontitis treatment with the help of alpha-lipoic acid in short-term and long-term period. The patients were undergone clinical evaluation of periodontal status according to general indexes and data of laboratory examinations prior to treatment, in 14 days and in 12 months. After intaking of 600 mg of alpha-lipoic acid per day during 14 days the condition of periodontitis tissues in the reference group and in the basic group has no statistically significant differences. The basic group took alpha-lipoic acid during 2 months, that favored improving of clinical and laboratory indexes. In comparison with the reference group in the basic group PMA index decreased in 2.3 times, IIS in 1.4 times, BPI in 1.8 times, complex parodontal index improved in 1.3 times, leucocytes emigration decreased in 1.2 times and microbial contamination of epithelium in 1.22 times. Efficiency of anti-inflammatory therapy was 1.4 times higher. Depth of gingival pockets and level of oral hygiene had no statistical significant differences.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Lakhtin
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D005888:Gingival Pocket / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D019216:Metals, Heavy / Q000633:toxicity; D009910:Oral Hygiene; D010518:Periodontitis / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D012492:Salts / Q000633:toxicity; D008063:Thioctic Acid / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D019216:Metals, Heavy; D012492:Salts; D008063:Thioctic Acid