title: Increased P-wave dispersion in patients with newly diagnosed lichen planus.
abstract: OBJECTIVE
  Lichen planus is a chronic inflammatory autoimmune mucocutaneous disease. Recent research has emphasized the strong association between inflammation and both P-wave dispersion and dyslipidemia. The difference between the maximum and minimum P-wave durations on an electrocardiogram is defined as P-wave dispersion. The prolongation of P-wave dispersion has been demonstrated to be an independent risk factor for developing atrial fibrillation. The aim of this study was to investigate P-wave dispersion in patients with lichen planus.
  
  
  METHODS
  Fifty-eight patients with lichen planus and 37 age- and gender-matched healthy controls were included in this study. We obtained electrocardiographic recordings from all participants and used them to calculate the P-wave variables. We also assessed the levels of highly sensitive C-reactive protein, which is an inflammatory marker, and the lipid levels for each group. The results were reported as the means ± standard deviations and percentages.
  
  
  RESULTS
  The P-wave dispersion was significantly higher in lichen planus patients than in the control group. Additionally, highly sensitive C-reactive protein, LDL cholesterol, and triglyceride levels were significantly higher in lichen planus patients compared to the controls. There was a significant positive correlation between highly sensitive C-reactive protein and P-wave dispersion (r=0.549, p<0.001) in lichen planus patients.
  
  
  CONCLUSIONS
  P-wave dispersion increased on the surface electrocardiographic measurements of lichen planus patients. This result may be important in the early detection of subclinical cardiac involvement. Increased P-wave dispersion, in terms of the tendency for atrial fibrillation, should be considered in these patients.
authors.affiliation: Yuzunci Yil University, Faculty of Medicine, Cardiology Department, Van, Turkey. drmusasahin@gmail.com
authors.forename: Musa
authors.initials: M
authors.lastname: Sahin
authors.forename: Serap Gunes
authors.initials: SG
authors.lastname: Bilgili
authors.forename: Hakki
authors.initials: H
authors.lastname: Simsek
authors.forename: Serkan
authors.initials: S
authors.lastname: Akdag
authors.forename: Aytac
authors.initials: A
authors.lastname: Akyol
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Gumrukcuoglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yaman
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Bayram
authors.forename: Ayse Serap
authors.initials: AS
authors.lastname: Karadag
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000209:etiology / Q000503:physiopathology*; D016022:Case-Control Studies; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012016:Reference Values; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult