title: [Experimental substantiation for the application of calcium channel blockers in vibration disease].
abstract: The mechanism of vibroprotective action for nifedipine, a calcium channel blocker, was studied in myocardiocytes of rabbits. The shifts in functional activity of mitochondria were registered after prolonged common vibration of rabbits during 56 days (1 h every day). Nifedipine (7.5 mg/kg per os) activated NAD-depended site of respiratory chain and prevented hyperactivation of succunate-depended breath. The positive energotropic action of nifedipine was accompanied by stability of histomorphological cytoarchitechture of rabbit myocardium, wich was disturbed in nontreated animals. It is suggested that nifedipine protects myocardium from prolonged action of vibration.
authors.forename: V V
authors.initials: VV
authors.lastname: Vorob'eva
authors.forename: P D
authors.initials: PD
authors.lastname: Shabanov
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology*; D011817:Rabbits; D014732:Vibration / Q000009:adverse effects*
chemical_list: D002121:Calcium Channel Blockers; D009543:Nifedipine