title: Thrombosis in central obesity and metabolic syndrome: mechanisms and epidemiology.
abstract: Central obesity is a key feature of the metabolic syndrome (metS), a multiplex risk factor for subsequent development of type 2 diabetes and cardiovascular disease. Many metabolic alterations closely related to this condition exert effects on platelets and vascular cells. A procoagulant and hypofibrinolytic state has been identified, mainly underlain by inflammation, oxidative stress, dyslipidaemia, and ectopic fat that accompany central obesity. In support of these data, central obesity independently predisposes not only to atherothrombosis but also to venous thrombosis.
authors.affiliation: Marie-Christine Alessi, Laboratoire d'Hématologie, Inserm UMR 1062, Faculté de Médecine, Université de la Méditerranée, 27 Bd Jean Moulin, Marseille, F-13385 France, Tel.: +33 4 91 32 45 06, Fax: +33 4 91 25 43 36, E-mail: marie-christine.alessi@univ-amu.fr.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Morange
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Alessi
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D002828:Choristoma / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D056128:Obesity, Abdominal / Q000150:complications / Q000453:epidemiology*; D018384:Oxidative Stress; D013927:Thrombosis / Q000150:complications / Q000453:epidemiology*
keywords: Haemostasis; metabolic syndrome; thrombosis; visceral obesity