title: Organic solvent-induced bipolar disorder: a case report.
abstract: Many studies have reported neurological and neuropsychiatric symptoms, including a significantly increased risk of depression and suicide, from exposure to low to moderate levels of organic solvents. However, few studies have reported a link between organic solvent exposure and bipolar disorder. The authors present a case of a 43-y-old man who developed new-onset bipolar disorder following exposure to organic solvents in a textile printing plant. The man had elevated blood levels of several common solvents. His symptoms abated following avoidance of solvent exposures at his workplace and after nutritional and sauna detoxification treatments that one of the authors formulated to clear xenobiotics. Following avoidance and detoxification, the patient's blood concentrations of organic solvents fell to undetectable levels and his manic symptoms disappeared, with no significant recurrences over the past 13 y, as evaluated by the authors and his other physicians.
authors.affiliation: Manhattan Health Consultants, New York, NY, USA.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Sprouse
authors.forename: Luke
authors.initials: L
authors.lastname: Curtis
authors.forename: Barbara
authors.initials: B
authors.lastname: Bartlik
mesh_terms: D000328:Adult; D000473:Alkanes / Q000097:blood / Q000506:poisoning; D000975:Antioxidants / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D002617:Chemical Industry; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D016273:Occupational Exposure / Q000009:adverse effects*; D012997:Solvents / Q000032:analysis / Q000506:poisoning; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D000473:Alkanes; D000975:Antioxidants; D012997:Solvents; D014815:Vitamins