title: Secondary metabolites from Penicillium pinophilum SD-272, a marine sediment-derived fungus.
abstract: Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and L-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5-10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD₅₀ 11.2 μM.
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Wang
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Li
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.forename: Nai-Yun
authors.initials: NY
authors.lastname: Ji
authors.forename: Bin-Gui
authors.initials: BG
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D019015:Geologic Sediments / Q000382:microbiology*; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010407:Penicillium / Q000378:metabolism*; D018675:Toxicity Tests / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents