title: The physicochemical properties of a new class of anticancer fungal polysaccharides: a comparative study.
abstract: The structural and physicochemical properties of polysaccharides isolated from fungi with anticancer properties were investigated. The majority of the polysaccharides considered, have the β-d-Glcp component mostly connected by 1→3 and 1→6 linkages in the backbones and the short branches, respectively. The established parameters of lead-like, drug-like and of known dug space (KDS) were used and the repeating units of the polysaccharides exhibit some overlap with these. It was found that a unique region of chemical space is occupied by the polysaccharides, with MW: 1.0 x 10(5) to 2.5 x 10(5) g mol(-1); LogP: -3.0 x 10(3) to -1.0 x 10(3); HD: 1.0 x 10(3) to 5.0 x 10(3); HA: 5.0 x 10(3) to 1.0 x 10(4); PSA: 5.0 x 10(4) to 1.0 x 10(5) and RB: 5.0 x 10(3) to 1.0 x 10(4). These findings can be exploited in antitumor drug discovery projects.
authors.affiliation: School of Chemical Sciences, The University of Auckland, Auckland, New Zealand.
authors.forename: Lu
authors.initials: L
authors.lastname: Ren
authors.forename: Jóhannes
authors.initials: J
authors.lastname: Reynisson
authors.forename: Conrad
authors.initials: C
authors.lastname: Perera
authors.forename: Yacine
authors.initials: Y
authors.lastname: Hemar
mesh_terms: D000363:Agaricales / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D016208:Databases, Factual; D062610:Fungal Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification; D005658:Fungi / Q000378:metabolism*; D006860:Hydrogen Bonding; D008970:Molecular Weight; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D062610:Fungal Polysaccharides