title: Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions.
abstract: Spirocyclopenteneoxindole derivatives were obtained by stereoselective triphenylphosphine-catalyzed [3+2] cycloadditions of ynones and alkylidene oxindole derivatives. This approach is based on the Michael addition of ynones to alkylidene oxindole derivatives, followed by intermolecular [Formula: see text]-addition using 50 mol% triphenylphosphine as catalyst.
authors.affiliation: School of Basic Sciences, China Pharmaceutical University, Nanjing, 210009, People's Republic of China. zhouqingfa@cpu.edu.cn
authors.forename: Qing-Fa
authors.initials: QF
authors.lastname: Zhou
authors.forename: Xue-Ping
authors.initials: XP
authors.lastname: Chu
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Ge
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Lu
mesh_terms: D002384:Catalysis; D061565:Cycloaddition Reaction; D003517:Cyclopentanes / Q000138:chemical synthesis*; D015195:Drug Design; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry*; D000078183:Oxindoles; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D003517:Cyclopentanes; D007211:Indoles; D009943:Organophosphorus Compounds; D000078183:Oxindoles; D013141:Spiro Compounds; C022960:2-oxindole; C061896:triphenylphosphine