title: Silver-doped self-assembling di-phenylalanine hydrogels as wound dressing biomaterials.
abstract: Chronic and acute wounds can be quickly contaminated and infected by microorganisms such as bacteria, multi-resistant organisms or fungi. The introduction of silver as anti-microbial agent into wound management has widely been demonstrated to be effective and contribute to wound healing. As a consequence, many approaches and different materials have been employed to synthesize antibacterial silver-hydrogels. In this work the introduction of silver particles into the fibrillar structure of self-assembling aromatic di-phenylalanine derivatives modified with aromatic groups such as 9-fluorenylmethoxycarbonyl is proposed to produce antibacterial wound dressings. Hydrogels doped with increasing amounts of silver were tested and adopted to modify flax textiles. The influence of silver on the structure of hydrogels was studied using light and confocal microscopy, while SEM-EDX allowed the characterization of the hydrogel coating on the surface of the textile substrates as well as the identification and distribution of silver nanoparticles. The antibacterial potential of the treated flax was demonstrated through microbiological tests on Staphylococcus aureus. The combination of the physico-chemical and anti-bacterial properties, together with the ease of preparation of these biomaterials, fulfils the requirement of clinically-effective wound dressings.
authors.affiliation: Department of Engineering for Innovation, University of Salento, 73100, Lecce, Italy, federica.paladini@unisalento.it.
authors.forename: Federica
authors.initials: F
authors.lastname: Paladini
authors.forename: S T
authors.initials: ST
authors.lastname: Meikle
authors.forename: I R
authors.initials: IR
authors.lastname: Cooper
authors.forename: J
authors.initials: J
authors.lastname: Lacey
authors.forename: V
authors.initials: V
authors.lastname: Perugini
authors.forename: M
authors.initials: M
authors.lastname: Santin
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D000890:Anti-Infective Agents / Q000737:chemistry*; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry*; D018441:Biofilms; D002851:Chromatography, High Pressure Liquid; D005449:Fluorenes / Q000737:chemistry; D005782:Gels; D020100:Hydrogels / Q000737:chemistry*; D013058:Mass Spectrometry; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D010455:Peptides / Q000737:chemistry; D010649:Phenylalanine / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D018030:Silver Compounds / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
chemical_list: C496789:9-fluorenylmethoxycarbonyl; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D005449:Fluorenes; D005782:Gels; D020100:Hydrogels; D010455:Peptides; D018030:Silver Compounds; D012834:Silver; D010649:Phenylalanine