title: Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept.
abstract: Here, we report the case of a patient with a non-seminoma of the left testicle, with an intestinal-type adenocarcinoma and a low grade leiomyosarcoma in a late recurrence 19 years after initial diagnosis. The history of the patient, alive with disease 21 years after initial treatment, illustrates the potential and flaw of the cancer stem cell therapy concept. In addition, it is proposed that residual mature teratoma can be regarded as normalization of cancer due to embryonic patterning, and the development of a secondary somatic-type malignancy as failure of normalization.
authors.affiliation: Department of Pathology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. j.w.oosterhuis@erasmusmc.nl
authors.forename: J Wolter
authors.initials: JW
authors.lastname: Oosterhuis
authors.forename: Suzanne H P
authors.initials: SH
authors.lastname: Peeters
authors.forename: Vincent T H B M
authors.initials: VT
authors.lastname: Smit
authors.forename: Hans
authors.initials: H
authors.lastname: Stoop
authors.forename: Leendert H J
authors.initials: LH
authors.lastname: Looijenga
authors.forename: Henk W
authors.initials: HW
authors.lastname: Elzevier
authors.forename: Suzanne
authors.initials: S
authors.lastname: Osanto
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D000328:Adult; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D007422:Intestines / Q000473:pathology*; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications* / Q000473:pathology / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000473:pathology*; D011379:Prognosis; D013736:Testicular Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy