title: Thwarting galectin-induced immunosuppression in breast cancer.
abstract: Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4+CD25+FOXP3+regulatory T cells.
authors.affiliation: Laboratorio de Inmunopatología; Instituto de Biología y Medicina Experimental (IBYME-CONICET); Buenos Aires, Argentina.
authors.forename: Mariana
authors.initials: M
authors.lastname: Salatino
authors.forename: Tomas
authors.initials: T
authors.lastname: Dalotto-Moreno
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Rabinovich
keywords: Galectin-1; breast cancer; immune escape; metastasis; regulatory T cell