title: Intracranial EEG evaluation of relationship within a resting state network.
abstract: OBJECTIVE
  We tested if a relationship between distant parts of the default mode network (DMN), a resting state network defined by fMRI studies, can be observed with intracranial EEG recorded from patients with localization-related epilepsy.
  
  
  METHODS
  Magnitude squared coherence, mutual information, cross-approximate entropy, and the coherence of the gamma power time-series were estimated, for one hour intracranial EEG recordings of background activity from 9 patients, to evaluate the relationship between two test areas which were within the DMN (anterior cingulate and orbital frontal, denoted as T1 and posterior cingulate and mesial parietal, denoted as T2), and one control area (denoted as C), which was outside the DMN. We tested if the relationship between T1 and T2 was stronger than the relationship between each of these areas and C.
  
  
  RESULTS
  A low level of relationship was observed among the 3 areas tested. The relationships among T1, T2 and C did not demonstrate support for the DMN.
  
  
  CONCLUSIONS
  This study suggests a lack of intracranial EEG support for the fMRI defined default mode network.
  
  
  CONCLUSIONS
  The results obtained underscore the considerable difference between electrophysiological and hemodynamic measurements of brain activity and possibly suggest a lack of neuronal involvement in the DMN.
authors.affiliation: Department of Electrical Engineering, Yale University, New Haven, CT 06511, USA. dominique.duncan@yale.edu
authors.forename: Dominique
authors.initials: D
authors.lastname: Duncan
authors.forename: Robert B
authors.initials: RB
authors.lastname: Duckrow
authors.forename: Steven M
authors.initials: SM
authors.lastname: Pincus
authors.forename: Irina
authors.initials: I
authors.lastname: Goncharova
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Hirsch
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Spencer
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Coifman
authors.forename: Hitten P
authors.initials: HP
authors.lastname: Zaveri
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping / Q000379:methods; D002648:Child; D004569:Electroencephalography / Q000379:methods*; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D010296:Parietal Lobe / Q000503:physiopathology*; D055815:Young Adult
keywords: Coherence; Cross-approximate entropy; Epilepsy; Gamma power; Mutual information; Resting state networks