title: Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy.
abstract: BACKGROUND
  It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors.
  
  
  METHODS
  Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors.
  
  
  RESULTS
  Hypertension prevalence was 22%(95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not.
  
  
  CONCLUSIONS
  Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.
authors.forename: Katherine
authors.initials: K
authors.lastname: Krauskopf
authors.forename: Mark L
authors.initials: ML
authors.lastname: Van Natta
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Danis
authors.forename: Sapna
authors.initials: S
authors.lastname: Gangaputra
authors.forename: Lori
authors.initials: L
authors.lastname: Ackatz
authors.forename: Adrienne
authors.initials: A
authors.lastname: Addessi
authors.forename: Alex D
authors.initials: AD
authors.lastname: Federman
authors.forename: Andrea D
authors.initials: AD
authors.lastname: Branch
authors.forename: Curtis L
authors.initials: CL
authors.lastname: Meinert
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Jabs
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000453:epidemiology* / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000821:virology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology