title: A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis.
abstract: BACKGROUND
  To validate the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) scoring system in patients with severe sepsis, we conducted a multicenter, prospective study at 15 critical care centers in tertiary care hospitals.
  
  
  METHODS
  This study included 624 severe sepsis patients. JAAM DIC was scored on the day of diagnosis of severe sepsis (day 1) and day 4. Scores for disease severity and organ dysfunction were also evaluated.
  
  
  RESULTS
  The prevalence of JAAM DIC was 46.8% (292/624), and 21% of the DIC patients were scored according to the reduction rate of platelets. The JAAM DIC patients were more seriously ill and exhibited more severe systemic inflammation, a higher prevalence of multiple organ dysfunction syndrome (MODS) and worse outcomes than the non-DIC patients. Disease severity, systemic inflammation, MODS and the mortality rate worsened in accordance with an increased JAAM DIC score on day 1. The Kaplan-Meier curves demonstrated lower 1-year survival in the JAAM DIC patients than in those without DIC (log-rank test P<0.001). The JAAM DIC score on day 1 (odds ratio=1.282, P<0.001) and the Delta JAAM DIC score (odds ratio=0.770, P<0.001) were independent predictors of 28-day death. Dynamic changes in the JAAM DIC score from days 1 to 4 also affected prognoses. The JAAM DIC scoring system included all patients who met the International Society on Thrombosis and Haemostasis overt DIC criteria on day 1. The International Society on Thrombosis and Haemostasis scoring system missed a large number of nonsurvivors recognized by the JAAM scoring system.
  
  
  CONCLUSIONS
  The JAAM DIC scoring system exhibits good prognostic value in predicting MODS and poor prognosis in patients with severe sepsis and can detect more patients requiring treatment. Conducting repeated daily JAAM scoring increases the ability to predict the patient's prognosis.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Gando
authors.forename: Daizoh
authors.initials: D
authors.lastname: Saitoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogura
authors.forename: Seitaro
authors.initials: S
authors.lastname: Fujishima
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Mayumi
authors.forename: Tsunetoshi
authors.initials: T
authors.lastname: Araki
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ikeda
authors.forename: Joji
authors.initials: J
authors.lastname: Kotani
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kushimoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Miki
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Shiraishi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Naoshi
authors.initials: N
authors.lastname: Takeyama
authors.forename: Kiyotsugu
authors.initials: K
authors.lastname: Takuma
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tsuruta
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Norio
authors.initials: N
authors.lastname: Yamashita
authors.forename: Naoki
authors.initials: N
authors.lastname: Aikawa
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018805:Sepsis / Q000175:diagnosis* / Q000453:epidemiology*; D012720:Severity of Illness Index; D012955:Societies, Medical / Q000592:standards*