title: Poor postnatal head growth in very preterm infants is associated with impaired neurodevelopment outcome.
abstract: OBJECTIVE
  To examine the association between neurodevelopmental outcome and head circumference (HC) in a cohort of very preterm infants and in this context to investigate the relevance of suboptimal head size.
  
  
  METHODS
  Somatometric data were obtained at birth, discharge and 3, 12 and 24 months for all infants born in Tyrol <32 weeks gestational age. Growth data are presented as z scores. HC was defined as microcephaly (>2 SD below mean), suboptimal (>1 SD below mean) or normal head size (<1 SD below mean). Neurodevelopmental outcome was quantified at 12 and 24 months using the Bayley Scales of Infant Development II.
  
  
  RESULTS
  The percentage of infants with suboptimal head size increased until the age of 24 months and was related to adverse outcome. The association was strongest between HC at 3 months and psychomotor and mental outcome as quantified using the Bayley Scales of Infant Development.
  
  
  CONCLUSIONS
  Poor postnatal head growth was common in our study cohort. Both microcephaly and suboptimal head size were associated with impaired neurodevelopmental outcome. Suboptimal head size at 3 months was found to be particularly associated with adverse neurodevelopmental outcome.
authors.affiliation: Department of Paediatrics II, Neonatology, Innsbruck Medical University, Innsbruck, Austria. Vera.Neubauer@i-med.ac.at
authors.forename: Vera
authors.initials: V
authors.lastname: Neubauer
authors.forename: Elke
authors.initials: E
authors.lastname: Griesmaier
authors.forename: Nicola
authors.initials: N
authors.lastname: Pehböck-Walser
authors.forename: Ulrike
authors.initials: U
authors.lastname: Pupp-Peglow
authors.forename: Ursula
authors.initials: U
authors.lastname: Kiechl-Kohlendorfer
mesh_terms: D000367:Age Factors; D002508:Cephalometry / Q000379:methods; D002657:Child Development / Q000502:physiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006257:Head / Q000254:growth & development*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D008607:Intellectual Disability / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D058627:Megalencephaly / Q000175:diagnosis / Q000453:epidemiology; D008831:Microcephaly / Q000175:diagnosis / Q000453:epidemiology; D011181:Postnatal Care; D018570:Risk Assessment; D018709:Statistics, Nonparametric
keywords: Head growth; Neurodevelopment; Postnatal growth; Preterm