title: Organocatalytic asymmetric sulfa-Michael addition of thiols to α,β-unsaturated hexafluoroisopropyl esters: expeditious access to (R)-thiazesim.
abstract: A highly efficient organocatalytic asymmetric SMA reaction of hexafluoroisopropyl α,β-unsaturated esters has been developed. Introducing electron-withdrawing hexafluoroisopropyl ester is crucial to enhancing the electrophilicity of unsaturated esters as SMA acceptors. The catalytic system performs well over a broad scope of α,β-unsaturated esters and diversified thiols and provides facile access to (R)-thiazesim in a one-pot protocol.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Fang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D004952:Esters; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013841:Thiazepines / Q000737:chemistry*
chemical_list: D004952:Esters; D006845:Hydrocarbons, Fluorinated; D013438:Sulfhydryl Compounds; D013841:Thiazepines; C003436:thiazesim