title: Adipokines and hepatic insulin resistance.
abstract: Obesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. Recent studies have shown that these factors might provide a molecular link between increased adiposity and impaired insulin sensitivity. Since hepatic insulin resistance plays the key role in the whole body insulin resistance, clarification of the regulatory processes about hepatic insulin resistance by adipokines in rodents and human would seem essential in order to understand the mechanism of type 2 diabetes and for developing novel therapeutic strategies to treat it.
authors.affiliation: National Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Ding
authors.forename: Waseem
authors.initials: W
authors.lastname: Hassan
authors.forename: Daoud
authors.initials: D
authors.lastname: Abdelkader
authors.forename: Jing
authors.initials: J
authors.lastname: Shang
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000378:metabolism* / Q000503:physiopathology; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D054392:Adipokines