title: Serum selenium levels of the very low birth weight premature newborn infants with bronchopulmonary dysplasia.
abstract: BACKGROUND
  The selenium (Se) is an essential trace element that has a critical role in synthesis and activity of a number of selenoproteins with protective properties against free radical damage. This study was conducted to detect the serum Se concentration in very low birth weight (VLBW) preterm infants and its association with bronchopulmonary dysplasia (BPD).
  
  
  METHODS
  Cord blood Se concentration was determined in 54 neonates with gestation age 30 week or less. Another sample was obtained from these infants at day 28 of birth and serum Se levels were measured by atomic absorption spectrophotometer. All neonates were followed for oxygen dependency at 28 day after birth and 36 week postmenstrual age.
  
  
  RESULTS
  The mean cord blood Se concentration in studied neonates was 64.78 ± 20.73 μgL(-1). Serum Se concentration was 60.33 ± 26.62 μgL(-1) at age 28-day. No significant correlation was observed for serum Se concentration at birth and at one month after birth (r = -0.04, p = 0.72). BPD was diagnosed in 25 neonates (46%). The mean serum Se concentration at one month was 57.16 ± 29.68 μgL(-1) in patients with BPD (25 cases) and 63.27 ± 23.6 μgL(-1) in 29 patients without BPD (p = 0.40).
  
  
  CONCLUSIONS
  In our study, serum Se concentration at 28 day of birth was lower than cord blood levels in preterm neonates, but we have not found significant difference among patients who had BPD or not with respect to serum Se concentrations at this age.
authors.affiliation: Depatrment of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Peirovifar
authors.forename: Manizheh Mostafa
authors.initials: MM
authors.lastname: Gharehbaghi
authors.forename: Hossein
authors.initials: H
authors.lastname: Abdulmohammad-Zadeh
authors.forename: Gholam Hossein
authors.initials: GH
authors.lastname: Sadegi
authors.forename: Abulghasem
authors.initials: A
authors.lastname: Jouyban
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D012643:Selenium / Q000097:blood*
chemical_list: D012643:Selenium
keywords: Bronchopulmonary dysplasia; Cord blood; Preterm infants; Selenium