title: Olanzapine versus haloperidol: which can control stuttering better?
abstract: BACKGROUND
  The aim of this study was to compare the effects of olanzapine versus haloperidol to control the signs and symptoms of stuttering.
  
  
  METHODS
  Ninety-three patients were recruited in a 12-week single-blind randomized clinical trial, which was held between October 2009 and October 2010. Forty-three patients received olanzapine (5 mg/day) and 50 patients, haloperidol (2.5 mg/day). Before and after the study, they were evaluated by a speech pathologist by Van Riper's questionnaire. The data were analyzed using the SPSS version 16. T-test was used to compare the data between the two groups.
  
  
  RESULTS
  Mean of stuttering score (SD) before treatment was 4.67 (0.81) and 4.40 (1.14) in haloperidol and olanzapine groups, respectively (P > 0.05). After treatment, the mean (SD) score was 2.87 (1.32) and 1.56 (0.71) in haloperidol and olanzapine groups, respectively (P = 0.000).
  
  
  CONCLUSIONS
  It seems that olanzapine does have better impact in controlling stuttering, and it may be recommended to prescribe olanzapine for stutters as the first choice to control the stuttering under a careful follow-up.
authors.affiliation: Department of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Shaygannejad
authors.forename: Seyed Ahmadreza
authors.initials: SA
authors.lastname: Khatoonabadi
authors.forename: Bijan
authors.initials: B
authors.lastname: Shafiei
authors.forename: Majid
authors.initials: M
authors.lastname: Ghasemi
authors.forename: Farzad
authors.initials: F
authors.lastname: Fatehi
authors.forename: Rokhsareh
authors.initials: R
authors.lastname: Meamar
authors.forename: Leila
authors.initials: L
authors.lastname: Dehghani
keywords: Haloperidol; olanzapine; stuttering