title: Is a booster dose necessary in children after immunization with live attenuated Japanese encephalitis vaccine?
abstract: Japanese encephalitis virus is a common cause of encephalitis in Asian children; therefore, maintenance of immunity against Japanese encephalitis virus is essential. Although many countries recommend booster vaccination, some trials have concluded that administration of one or two vaccinations is sufficient. The current study was conducted to evaluate immunogenicity and safety after a booster vaccination with live attenuated vaccine. For 68 study subjects, measurement of antibody titer was performed before and at 4-6 weeks after administration of a booster dose. Adverse reactions occurring at the injection site and systemic adverse reactions were documented. The percentages of subjects with seroprotective neutralizing antibody titers was 100% before and after booster vaccination, and the geometric mean titer increased after booster vaccination. Thus, we predict that immunity will be maintained for a long time by an amnestic response. Low percentages of adverse reactions indicated the safety of the immunizations.
authors.affiliation: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ui Yoon
authors.initials: UY
authors.lastname: Choi
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Ki Hwan
authors.initials: KH
authors.lastname: Kim
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Kim
authors.forename: Kyong Min
authors.initials: KM
authors.lastname: Choi
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Cha
authors.forename: Jin Han
authors.initials: JH
authors.lastname: Kang
mesh_terms: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D004672:Encephalitis, Japanese / Q000517:prevention & control* / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D007117:Immunization, Secondary; D022321:Japanese Encephalitis Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D009500:Neutralization Tests; D056910:Republic of Korea; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D022321:Japanese Encephalitis Vaccines; D014613:Vaccines, Attenuated
keywords: Japanese encephalitis; booster; immunogenicity; live attenuated Japanese encephalitis vaccine; safety