title: [Impact of chemical and physical environmental factors on the course and outcome of pregnancy].
abstract: We review the epidemiological literature on the possible impact of chemical and physical factors on pregnancy outcome. Effects of in-utero exposures on child health are not considered here. The highest levels of evidence concern the effects of passive smoking (on fetal growth), of lead (pregnancy-induced hypertension, fetal growth), of some Polychlorinated Biphenyls (PCB; on fetal growth) and, to a lesser extent, of atmospheric pollutants (on fetal growth and preterm delivery). For the other compounds, in particular non-persistent chemicals, the literature, which is generally based on poor exposure assessment, is less informative. In conclusion, the last decades have witnessed the development of mother-child cohorts in which exposure biomarkers have been assayed, allowing a large number of publications. For some persistent compounds, for which efficient exposure assessment approaches have been used, the literature indicates a likely impact on pregnancy outcomes. With the exception of air pollutants, the literature on non-persistent compounds is little conclusive; the assay of exposure biomarkers in repeated biological samples collected at relevant time points could help further increase knowledge regarding any health impact.
authors.affiliation: Inserm,Équipe D'épidémiologie Environnementale Appliquée à la Reproduction et la Santé Respiratoire, U823, Université Joseph-Fourier, UJF sité Santé, rond-point de la Chantourne, 38042 Grenoble, France. remy.slama@ujf-grenoble.fr
authors.forename: R
authors.initials: R
authors.lastname: Slama
authors.forename: S
authors.initials: S
authors.lastname: Cordier
mesh_terms: D004777:Environment; D004785:Environmental Pollutants / Q000494:pharmacology*; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects / Q000706:statistics & numerical data; D011247:Pregnancy / Q000187:drug effects; D011256:Pregnancy Outcome / Q000453:epidemiology; D047928:Premature Birth / Q000139:chemically induced / Q000453:epidemiology; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors
chemical_list: D004785:Environmental Pollutants
keywords: Cohort; Cohorte; Environment; Environnement; Epidemiology; Fetus; Fœtus; Grossesse; Pregnancy; Épidémiologie