title: Unidirectional migration of single smooth muscle cells under the synergetic effects of gradient swelling cue and parallel groove patterns.
abstract: The air-plasma treated poly(dimethylsiloxane) membrane with linear grooves and ridges is alternately assembled with poly(sodium 4-styrenesulfonate) (PSS)/poly(diallyldimethylammonium) chloride (PDADMAC) multilayers, which is then treated in a gradient solution of 3-5M NaCl, with the pattern direction parallel to the gradient. The synergetic effects of the surface topography and swelling gradient can effectively guide the unidirectional migration of single smooth muscle cells without impairment of their migration rate.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Han
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: zwmao@zju.edu.cn.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Mao
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Jindan
authors.initials: J
authors.lastname: Wu
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Guo
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Tanchen
authors.initials: T
authors.lastname: Ren
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: cygao@mail.hz.zj.cn.
authors.forename: Changyou
authors.initials: C
authors.lastname: Gao
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D003599:Cytoskeleton / Q000187:drug effects; D004573:Electrolytes / Q000494:pharmacology; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000187:drug effects; D011095:Polyethylenes / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013499:Surface Properties; D059008:Time-Lapse Imaging
chemical_list: D004573:Electrolytes; D011095:Polyethylenes; D000644:Quaternary Ammonium Compounds; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride
keywords: Cell migration; Direction; Gradient; Groove patterns; Polyelectrolyte multilayers