title: Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update.
abstract: Kaposi sarcoma-associated herpesvirus (KSHV) is the etiological agent of several human malignancies. The virus is able to modulate pro-proliferative pathways to its advantage, while simultaneously inhibiting pro-apoptotic signaling pathways. These functions are carried out by multiple viral proteins acting in concert. The overall outcome is the survival and proliferation of the infected cell. Additionally, the virus also modulates innate immune pathways to allow for prolonged survival of the infected cell following primary infection, and during viral latency. Here we review the latest advances in our knowledge of KSHV pathogenesis.
authors.affiliation: Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, Program in Global Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
authors.forename: Dirk P
authors.initials: DP
authors.lastname: Dittmer
authors.forename: Blossom
authors.initials: B
authors.lastname: Damania
mesh_terms: D002472:Cell Transformation, Viral; D006566:Herpesviridae Infections / Q000473:pathology* / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000472:pathogenicity*; D006801:Humans; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D037521:Virulence Factors