title: Delivering on George Eisenbarth's visionary pursuit of understanding pathogenesis and prevention of type 1 diabetes.
abstract: George Eisenbarth's pioneering and visionary research has provided a critical foundation that will be built on in the years ahead as we progress toward prevention of type 1 diabetes. His almost 30-year old model that type 1 diabetes was a chronic and predictable autoimmune disease with multiple identifiable progressive stages with a potential for interventions to prevent progression to symptomatic diabetes has stood the test of time. To deliver on the Eisenbarth vision and his "unfinished journey," the field needs: (1) to improve detection of risk of type 1 diabetes, (2) to improve staging and prediction of progression, (3) to perform smaller, shorter, practical, and an increased number of prevention clinical trials, and (4) to increase awareness of the potential for risk detection, staging, and prevention of type 1 diabetes and benefit/risk of prevention.
authors.affiliation: JDRF, New York, New York 10004, USA. rinsel@jdrf.org
authors.forename: Richard A
authors.initials: RA
authors.lastname: Insel
mesh_terms: D001327:Autoimmune Diseases / Q000266:history / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D003362:Cost-Benefit Analysis; D003922:Diabetes Mellitus, Type 1 / Q000266:history / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D004198:Disease Susceptibility / Q000276:immunology; D042241:Early Diagnosis; D005260:Female; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008297:Male; D018448:Models, Immunological