title: Correlation between serum lipids and age-related macular degeneration: a case-control study.
abstract: BACKGROUND
  Age-related macular degeneration (AMD) is one of the leading causes of visual loss among people aged 65 yr and older. The pathophysiology of AMD is poorly understood. The purpose of this study was to evaluate the relationship between serum lipid concentrations and age-related macular degeneration.
  
  
  METHODS
  In this case-control study, total cholesterol (TCH), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) of 32 patients with AMD were compared with 32 subjects without AMD that were matched for age. Data were analyzed using Independent t and Chi-Square Tests.
  
  
  RESULTS
  TCH, LDL, and TG serum concentrations were significantly higher in AMD patients compared with control group (P<0.001, P<0.001 and P<0.017 respectively). There was no difference in HDL concentration between two groups (P=0.781).
  
  
  CONCLUSIONS
  High level of total cholesterol, TG and LDL were associated with increased risk of AMD. Results of this study suggest further research to better understand the underlying biological mechanisms of AMD related to serum cholesterol.
authors.affiliation: Birjand Atherosclerosis and Coronary Artery Research Centre, Department of Ophthalmology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Davari
authors.forename: Hoda
authors.initials: H
authors.lastname: Gheitasi
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Yaghobi
authors.forename: Behrouz
authors.initials: B
authors.lastname: Heydari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007492:Iran; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008268:Macular Degeneration / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Age-related macular degeneration; Cholesterol; Iran; Serum lipids; Triglycerides