title: Liver disease in cystic fibrosis.
abstract: The survival of patients with cystic fibrosis (CF) has progressively increased over recent decades, largely attributable to early diagnosis through newborn screening and advances in nutritional and respiratory care. As the life expectancy of patients with CF has improved, non-respiratory complications such as liver disease have become increasingly recognized. Biochemical derangements of liver enzymes in CF are common and may be attributed to a number of specific hepatobiliary abnormalities. Among them, Cystic Fibrosis-associated Liver Disease (CFLD) is clinically the most significant hepatic complication and is believed to have a significant impact on morbidity and mortality. However, there remains much conjecture about the extent of the adverse prognostic implications that a diagnosis of CFLD has on clinical outcomes. The purpose of this review is to give an overview of the current knowledge regarding liver disease in children with CF.
authors.affiliation: Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia; Medical School, University of Groningen, Groningen, The Netherlands.
authors.forename: Lisette
authors.initials: L
authors.lastname: Leeuwen
authors.affiliation: Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Australia.
authors.forename: Dominic A
authors.initials: DA
authors.lastname: Fitzgerald
authors.affiliation: Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Australia; Department of Gastroenterology, The Children's Hospital at Westmead, Sydney, Australia; James Fairfax Institute of Paediatric Nutrition, University of Sydney, Sydney, Australia. Electronic address: kevin.gaskin@health.nsw.gov.au.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Gaskin
mesh_terms: D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D042241:Early Diagnosis; D014943:Global Health; D006801:Humans; D015994:Incidence; D008107:Liver Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D011379:Prognosis; D012307:Risk Factors
keywords: Cholestasis; Cystic Fibrosis; Cystic Fibrosis-associated Liver Disease; Liver transplantation; Morbidity; Mortality