title: Comparative proteomics in acute myeloid leukemia.
abstract: The term proteomics was used for the first time in 1995 to describe large-scale protein analyses. At the same time proteomics was distinguished as a new domain of the life sciences. The major object of proteomic studies is the proteome, i.e. the set of all proteins accumulating in a given cell, tissue or organ. During the last years several new methods and techniques have been developed to increase the fidelity and efficacy of proteomic analyses. The most widely used are two-dimensional electrophoresis (2DE) and mass spectrometry (MS). In the past decade proteomic analyses have also been successfully applied in biomedical research. They allow one to determine how various diseases affect the pattern of protein accumulation. In this paper, we attempt to summarize the results of the proteomic analyses of acute myeloid leukemia (AML) cells. They have increased our knowledge on the mechanisms underlying AML development and contributed to progress in AML diagnostics and treatment.
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Luczak
authors.forename: Maciej
authors.initials: M
authors.lastname: Kaźmierczak
authors.forename: Luiza
authors.initials: L
authors.lastname: Hadschuh
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Lewandowski
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Komarnicki
authors.forename: Marek
authors.initials: M
authors.lastname: Figlerowicz
keywords: 2DE; acute myeloid leukemia; mass spectrometry; proteomics