title: [Comparative analysis of associations of polymorphic genes F2, F5, GP1BA and ACE with the risk of stroke development in Russian and Ukrainian populations].
abstract: The comparative analysis of the associations between G20210A polymorphism of F2 gene, G1691A polymorphism of F5 gene, -5T/C polymorphism of gene GP1BA, I/D polymorphism of gene ACE and the risk of development of the stroke in two ethnical samplings--Russian and Ukrainian populations--was conducted. It was shown that the patients of the Russian population with genotype DD have a higher level of the risk of ischemic stroke development (OR = 1.4, 95% CI [1.05; 1.78], p = 0.02), whereas genotypes I/I and I/D are associated with the lower level of risk of ischemic stroke (OR = 0.7, 95% CI [0.56; 0.95], p = 0.02). In the Ukrainian ethnical sampling, differences in distribution of genotypes and alleles frequencies between patients with stroke and healthy persons upon given polymorphic locus are not significant, and I/D polymorphism of gene ACE is not associated with the risk of development of the stroke (OR = 0.8, 95% CI [0.48; 1.32], p = 0.45). The G20210A polymorphism of gene F2, G1691A polymorphism of gene F5, -5T/C polymorphism of gene GP1BA are not associated with the risk of stroke in two ethnical samplings.
authors.forename: T V
authors.initials: TV
authors.lastname: Tupitsyna
authors.forename: E A
authors.initials: EA
authors.lastname: Bondarenko
authors.forename: S A
authors.initials: SA
authors.lastname: Kravchenko
authors.forename: P F
authors.initials: PF
authors.lastname: Tatarskiĭ
authors.forename: I M
authors.initials: IM
authors.lastname: Shepova
authors.forename: N A
authors.initials: NA
authors.lastname: Shamalov
authors.forename: S M
authors.initials: SM
authors.lastname: Kuznetsova
authors.forename: D V
authors.initials: DV
authors.lastname: Shul'zhenko
authors.forename: V I
authors.initials: VI
authors.lastname: Skvortsova
authors.forename: P A
authors.initials: PA
authors.lastname: Slominskiĭ
authors.forename: L A
authors.initials: LA
authors.lastname: Livshits
authors.forename: S A
authors.initials: SA
authors.lastname: Limborskaia
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D019038:Platelet Glycoprotein GPIb-IX Complex; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics*; D012426:Russia; D020521:Stroke / Q000235:genetics; D014455:Ukraine; D044465:White People / Q000235:genetics
chemical_list: D008562:Membrane Glycoproteins; D019038:Platelet Glycoprotein GPIb-IX Complex; C094990:adhesion receptor; D005165:Factor V; D011516:Prothrombin; D007703:Peptidyl-Dipeptidase A