title: Plasma klotho levels decrease in both anorexia nervosa and obesity.
abstract: OBJECTIVE
  The aim of this study was to examine the associations of klotho with body mass index (BMI) in patients with restricting-type anorexia nervosa (r-AN) and obesity.
  
  
  METHODS
  We examined plasma klotho as well as adiponectin and its isoform levels in comparison in 11 obese patients, 12 r-AN patients, and 11 control participants.
  
  
  RESULTS
  Plasma klotho levels were markedly lower in the obesity and r-AN groups than in the control group. Moreover, plasma klotho levels increased significantly after the recovery of BMI in r-AN patients. Total and high-molecular-weight adiponectin levels were significantly decreased only in obesity. There was no relationship between klotho and total adiponectin levels or klotho and respective adiponectin isoform levels in the entire study population.
  
  
  CONCLUSIONS
  These results suggest that klotho may reflect normal nutritional state, and that the decrease of klotho in r-AN and obesity may underlie the deteriorating processes of these disorders.
authors.affiliation: Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Marie
authors.initials: M
authors.lastname: Amitani
authors.forename: Akihiro
authors.initials: A
authors.lastname: Asakawa
authors.forename: Haruka
authors.initials: H
authors.lastname: Amitani
authors.forename: Kaori
authors.initials: K
authors.lastname: Kaimoto
authors.forename: Nanami
authors.initials: N
authors.lastname: Sameshima
authors.forename: Ken Ichiro
authors.initials: KI
authors.lastname: Koyama
authors.forename: Izumi
authors.initials: I
authors.lastname: Haruta
authors.forename: Minglun
authors.initials: M
authors.lastname: Tsai
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nakahara
authors.forename: Miharu
authors.initials: M
authors.lastname: Ushikai
authors.forename: Kai-Chun
authors.initials: KC
authors.lastname: Cheng
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hamada
authors.forename: Akio
authors.initials: A
authors.lastname: Inui
mesh_terms: D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood*; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D000090265:Klotho Proteins; D009752:Nutritional Status; D009765:Obesity / Q000097:blood*; D055815:Young Adult
chemical_list: D052242:Adiponectin; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: Adiponectin; Aging; Body mass index; Klotho; Obesity; Restricting-type anorexia nervosa