title: Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell.
abstract: A 21-year-old lady diagnosed with Stage 3 ovarian yolk sac tumor (YST) underwent primary cytoreductive fertility sparing surgery, followed by conventional courses of platinum-based chemotherapy and etoposide. Recurrence at cul-da-sac was noted after a short period of remission and secondary debulking performed followed by four cycles of conventional chemotherapy. The patient's disease progressed despite courses of treatments. A joint team management including a hematologist was commenced following the failure of conventional chemotherapies. Two cycles of high-dose chemotherapy (HDCT) with ifosfamide/cisplatin/etoposide (ICE) regimen, followed by autologous stem cell transplantation (ASCT) were given. With this salvage treatment, she remained in complete remission and disease-free for more than 30 months, while maintaining her reproductive function. These approaches appear to be effective as a salvage treatment in selected cases of patients with ovarian germ cell tumor, especially those who failed primary conventional chemotherapy.
authors.affiliation: Department of Obstetrics & Gynecology, Sultanah Bahiyah Hospital, Kedah, Malaysia.
authors.forename: N A
authors.initials: NA
authors.lastname: Abdullah
authors.forename: P N
authors.initials: PN
authors.lastname: Wang
authors.forename: K G
authors.initials: KG
authors.lastname: Huang
authors.forename: A S
authors.initials: AS
authors.lastname: Adlan
authors.forename: J
authors.initials: J
authors.lastname: Casanova
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018240:Endodermal Sinus Tumor / Q000628:therapy*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000628:therapy*; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous