title: Effect of green tea on postprandial antioxidant capacity, serum lipids, C-reactive protein and glucose levels in patients with coronary artery disease.
abstract: OBJECTIVE
  Cardiovascular risk factors have been identified in the postprandial state, particularly in patients with coronary artery disease (CAD). Tea consumption has been linked to cardiovascular risk reduction, but the beneficial effect of tea has not been investigated under postprandial conditions. The objective was to examine the effect of green tea on postprandial levels of plasma total antioxidant capacity (TAC), serum lipids, C-reactive protein (CRP) and glucose in patients with CAD.
  
  
  METHODS
  In a randomized controlled, parallel design with 2 arms, 43 patients with CAD were assigned to consume breakfast consisting of bread, butter and 330 ml water or tea (4.5 g green tea/330 ml, providing approximately 400 mg catechins). Blood samples were drawn immediately before and 1.5, 3 and 5 h after breakfast. TAC was measured in plasma with the ferric reducing antioxidant power of plasma and oxygen radical absorbance capacity assays. Total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides, glucose, CRP, uric acid and pancreatic lipase levels were measured in serum.
  
  
  RESULTS
  Tested biomarkers did not differ between tea and water group at baseline, 1.5, 3 and 5 h (P > 0.05) postprandially. However, TAC increased 1.5 and 3 h after consumption of breakfast with tea (P < 0.005), but no change was observed after consumption of breakfast with water. Serum triglycerides levels significantly increased 3 h after breakfast with water (P = 0.031), but not after breakfast with tea. Serum uric acid decreased 1.5 h after breakfast with tea (P = 0.038). Pancreatic lipase, CRP, total cholesterol, HDL-C, LDL-C and glucose levels remained unchanged after breakfast with tea at any time point (P > 0.05).
  
  
  CONCLUSIONS
  Tea consumption did not affect selected biomarkers at any postprandial time point in patients with CAD.
authors.affiliation: Unit of Human Nutrition, Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, 11855, Athens, Greece.
authors.forename: Antonios E
authors.initials: AE
authors.lastname: Koutelidakis
authors.forename: Loukianos
authors.initials: L
authors.lastname: Rallidis
authors.forename: Katerina
authors.initials: K
authors.lastname: Koniari
authors.forename: Demosthenes
authors.initials: D
authors.lastname: Panagiotakos
authors.forename: Michael
authors.initials: M
authors.lastname: Komaitis
authors.forename: Antonis
authors.initials: A
authors.lastname: Zampelas
authors.forename: Maria
authors.initials: M
authors.lastname: Anastasiou-Nana
authors.forename: Maria
authors.initials: M
authors.lastname: Kapsokefalou
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis*; D062408:Breakfast; D002097:C-Reactive Protein / Q000032:analysis*; D002392:Catechin / Q000008:administration & dosage; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006115:Greece; D006801:Humans; D007700:Kinetics; D008049:Lipase / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000032:analysis; D019518:Postprandial Period; D016037:Single-Blind Method; D013662:Tea / Q000737:chemistry; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D010636:Phenols; D013662:Tea; D014280:Triglycerides; D014527:Uric Acid; D002392:Catechin; D002097:C-Reactive Protein; D002784:Cholesterol; D008049:Lipase; C518354:PNLIP protein, human