title: Neuronal circuits that regulate feeding behavior and metabolism.
abstract: Neurons within the central nervous system receive humoral and central (neurotransmitter or neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent advances in mouse genetics combined with neuroanatomical and electrophysiological techniques have contributed to a better understanding of these central mechanisms. This review integrates recently defined cellular mechanisms and neural circuits relevant to the regulation of feeding behavior, energy expenditure, and glucose homeostasis by metabolic signals.
authors.affiliation: Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
authors.forename: Jong-Woo
authors.initials: JW
authors.lastname: Sohn
authors.forename: Joel K
authors.initials: JK
authors.lastname: Elmquist
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Williams
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000166:cytology* / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism
chemical_list: D009479:Neuropeptides; D018377:Neurotransmitter Agents
keywords: GABA; agouti-related peptide; electrophysiology; glutamate; melanocortin receptor; neuropeptide Y receptor