title: [The antioxidant enzyme activity in mouse liver mitochondria after nanosecond pulsed periodic X-ray exposure].
abstract: The effect of repetitive pulsed X-ray (4 ns pulse duration, 300 kV accelerating voltage; 2.5 kA electron beam current) on the antioxidant enzyme activity in mouse liver mitochondria has been investigated. The mitochondrial suspension was exposed to single 4000 pulse X-ray radiation with repetition rates ranging between 10 and 22 pps (pulsed dose was 0.3-1.8 x 10(-6) Gy/pulse, the total absorbed dose following a single exposure was 7.2 x 10(-3) Gy). It was shown that a short-time exposure to X-ray radiation changes the antioxidant enzyme activity in mouse liver mitochondria. The greatest effect was observed in the changes of the activity of the metal-containing enzymes: superoxide dismutase and glutathione peroxidase. The effect depends on the pulse repetition frequency and radiation dose.
authors.forename: I R
authors.initials: IR
authors.lastname: Kniazeva
authors.forename: V V
authors.initials: VV
authors.lastname: Ivanov
authors.forename: M A
authors.initials: MA
authors.lastname: Bol'shakov
authors.forename: L P
authors.initials: LP
authors.lastname: Zharkova
authors.forename: A V
authors.initials: AV
authors.lastname: Kereia
authors.forename: O P
authors.initials: OP
authors.lastname: Kutenkov
authors.forename: V V
authors.initials: VV
authors.lastname: Rostov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism / Q000528:radiation effects; D005979:Glutathione Peroxidase / Q000378:metabolism* / Q000528:radiation effects; D051379:Mice; D008930:Mitochondria, Liver / Q000201:enzymology / Q000528:radiation effects*; D011829:Radiation Dosage; D013482:Superoxide Dismutase / Q000378:metabolism* / Q000528:radiation effects; D014965:X-Rays
chemical_list: D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase