title: [Molecular mechanisms of gradient sensing in mesenchymal cells].
abstract: Cell migration is an important fundamental process. It occurs over the embryonic development, immune system responses, reparation and regeneration of damaged tissues. Abnormal migration is characteristic for many disorders such as cancer metastasis. Both external and intrinsic factors control directionality of cell movement. In case the external factors are of chemical nature the directed migration is called chemotaxis. Here we review current models of directional sensing in mesenchymal cells and compare them to well studied mechanisms of amoebal chemotaxis.
authors.forename: P A
authors.initials: PA
authors.lastname: Tiurin-Kuz'min
authors.forename: A V
authors.initials: AV
authors.lastname: Vorotnikov
authors.forename: V A
authors.initials: VA
authors.lastname: Tkachuk
mesh_terms: D000818:Animals; D016764:Cell Polarity; D002630:Chemotactic Factors / Q000378:metabolism; D002633:Chemotaxis / Q000502:physiology*; D004023:Dictyostelium / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D011554:Pseudopodia / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D002630:Chemotactic Factors; D010982:Platelet-Derived Growth Factor; D006861:Hydrogen Peroxide; D019869:Phosphatidylinositol 3-Kinases