title: [Effect of simvastatin on the oxygen transport function and prooxidant - antioxidant balance in blood].
abstract: The effects of simvastatin on the blood oxygen transport function and indices of prooxidant - antioxidant balance at incubation have been studied. Simvastatin at a concentration of 100 ng/ml increases p50 (the blood pO2 corresponding to its 50% oxygen saturation) at real values of pH and pCO2 from 39.53 + 2.41 (p <0.05) to 36.60 (36, 40, 37, 60) (p <0.05) mm Hg. An increase in the drug concentration led to a decrease in the level of this parameter, but in a dose-independent manner. In addition, the level of nitrates/nitrites in the blood plasma was also increased, which was evidence of increasing activity of the L-arginine-NO system. The indices of prooxidant - antioxidant balance exhibited no significant changes. The results demonstrate a new pleiotropic effect of simvastatin, which is realized via a change in the hemoglobin - oxygen affinity through modification of NO production. This effect must be taken into account in the treatment of pathology in the blood circulation.
authors.forename: N V
authors.initials: NV
authors.lastname: Glutkina
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism*; D001120:Arginine / Q000097:blood; D001692:Biological Transport; D004305:Dose-Response Relationship, Drug; D006454:Hemoglobins / Q000378:metabolism; D009569:Nitric Oxide / Q000097:blood; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D019821:Simvastatin / Q000494:pharmacology*
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D006454:Hemoglobins; D009569:Nitric Oxide; D001120:Arginine; D019821:Simvastatin; D010100:Oxygen