title: COMT Val158Met polymorphism and executive functions in obsessive-compulsive disorder.
abstract: This study investigated the association between the catechol-O-methyl transferase (COMT) Val158Met polymorphism and executive functions in 101 patients with obsessive-compulsive disorder (OCD) and 100 healthy-control subjects (HS). Results showed that there was no significant difference for the genotype distributions between the OCD and HS groups. OCD-Met carrier subgroup's TMT B-A difference and lexical fluency scores were found to be significantly poorer than both HS subgroups. These findings suggest that lower activity of COMT associated with the Met allele, leading to higher levels of dopamine in the prefrontal cortex, lead to poorer executive function in OCD.
authors.forename: Raşit
authors.initials: R
authors.lastname: Tükel
authors.forename: Hakan
authors.initials: H
authors.lastname: Gürvit
authors.forename: Nalan
authors.initials: N
authors.lastname: Öztürk
authors.forename: Berna
authors.initials: B
authors.lastname: Özata
authors.forename: Banu Aslantaş
authors.initials: BA
authors.lastname: Ertekin
authors.forename: Erhan
authors.initials: E
authors.lastname: Ertekin
authors.forename: Bengi
authors.initials: B
authors.lastname: Baran
authors.forename: Şiükriye Akça
authors.initials: ŞA
authors.lastname: Kalem
authors.forename: Deniz
authors.initials: D
authors.lastname: Büyükgök
authors.forename: Güher Saruhan
authors.initials: GS
authors.lastname: Direskeneli
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003072:Cognition Disorders / Q000209:etiology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D014633:Valine / Q000235:genetics; D055815:Young Adult
chemical_list: D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine