title: Pyruvate as a pivot point for oncogene-induced senescence.
abstract: Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically.
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Olenchock
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Vander Heiden
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D009857:Oncogenes / Q000235:genetics*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*
chemical_list: D011768:Pyruvate Dehydrogenase Complex