title: Solitary polypoid laryngeal xanthoma.
abstract: We report the case of a 51-year-old male smoker with diabetes mellitus and hyperlipidaemia and a long history of human immunodeficiency virus (HIV)/hepatitis C virus (HCV) infection treated with various antiretroviral regimes, who was referred to the otolaryngology department with progressive dysphonia. Fibre-optic laryngoscopy showed a solitary, yellowish-white pedunculated polyp on the anterior third of the left cord, with no other abnormality. Pathological analysis revealed a polypoid laryngeal xanthoma that was immunoreactive against CD68, perilipin, and adipophilin. This unusual laryngeal lesion in the clinical context of our patient suggests a possible role of antiretroviral treatment in the pathogenesis of these xanthomas.
authors.affiliation: Department of Pathology, La Fe University Hospital, School of Medicine and Dentistry, University of Valencia, Avenida Campanar 21, 46009 Valencia, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Vera-Sempere
authors.forename: Diego
authors.initials: D
authors.lastname: Collado-Martín
authors.forename: Beatriz
authors.initials: B
authors.lastname: Vera-Sirera