title: [Determination of seven strobilurin fungicide residues in Chinese herbs by liquid chromatography-tandem mass spectrometry coupled with solid phase extraction].
abstract: An LC-MS/MS method was developed for the simultaneously determination of seven strobilurin fungicide residues in Chinese herbs. The strobilurin fungicides include Z-metominostrobin, kresoxim-methyl, dimoxystrobin, picoxystrobin, pyraclostrobin, azoxystrobin and trifloxystrobin. The sample was extracted with ethyl acetate and cleaned-up by an amino SPE column. The seven strobilurin fungicide residues were separated on a C18 column with gradient elution of 1.0 per thousand formic acid and methanol as mobile phases, and detected by ESI-MS in positive ion and selective reaction monitoring (SRM) mode. External standard method was used to the quantification with good linear relationships (r > or = 0. 996). The LOQs were 2 micro g/kg for dimoxystrobin, picoxystrobin and trifloxystrobin, 4 mciro g/kg for pyraclostrobin and azoxystrobin, 10 micro g/kg for Z-metominostrobin and kresoxim-methyl. The recoveries were from 60.4% to 110% with the RSDs between 1.2% and 17%. The developed method is suitable for the determination and confirmation of the seven strobilurin fungicide residues in the three of Eight Zhes ( Ophiopogon japonicus (Thunb.), Scrophularia ningpoensis Hemsl. and Corydalis yanhusuo W T Wang).
authors.affiliation: College of Chemical Engineering and Material, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Yule
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Huang
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhu
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Chen
authors.forename: Weimin
authors.initials: W
authors.lastname: Mo
mesh_terms: D000085:Acetates / Q000032:analysis; D000179:Acrylates / Q000032:analysis; D002219:Carbamates / Q000032:analysis; D002853:Chromatography, Liquid / Q000379:methods*; D004340:Drug Contamination; D004350:Drug Residues / Q000032:analysis*; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D005659:Fungicides, Industrial / Q000032:analysis; D007097:Imines / Q000032:analysis; D008689:Methacrylates / Q000032:analysis*; D010648:Phenylacetates / Q000032:analysis; D011720:Pyrazoles / Q000032:analysis; D011725:Pyridines / Q000032:analysis; D011743:Pyrimidines / Q000032:analysis; D000073739:Strobilurins; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D000085:Acetates; D000179:Acrylates; D002219:Carbamates; D004365:Drugs, Chinese Herbal; D005659:Fungicides, Industrial; D007097:Imines; D008689:Methacrylates; D010648:Phenylacetates; D011720:Pyrazoles; D011725:Pyridines; D011743:Pyrimidines; D000073739:Strobilurins; C469328:kresoxim-methyl; C556557:picoxystrobin; C513428:pyrachlostrobin; C467051:trifloxystrobin; C087670:azoxystrobin