title: Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma.
abstract: Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with NHL risk after adjustment for multiple comparison. Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation.
authors.affiliation: Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yingtai
authors.initials: Y
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Holford
authors.forename: Catherine
authors.initials: C
authors.lastname: Lerro
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.forename: Huang
authors.initials: H
authors.lastname: Huang
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Liang
authors.forename: Shuangge
authors.initials: S
authors.lastname: Ma
authors.forename: Brian
authors.initials: B
authors.lastname: Leaderer
authors.forename: Peter
authors.initials: P
authors.lastname: Boyle
authors.forename: Stephen
authors.initials: S
authors.lastname: Chanock
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053613:Janus Kinase 1 / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D050791:STAT Transcription Factors / Q000235:genetics*; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C108944:SOCS1 protein, human; D050791:STAT Transcription Factors; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins; C507904:JAK1 protein, human; D053613:Janus Kinase 1
keywords: Case–control study; JAK/STAT signaling pathway; Non-Hodgkin lymphoma; Polymorphism