title: Pharmacogenetics of chronic pain and its treatment.
abstract: This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers.
authors.affiliation: First Faculty of Medicine, Institute of Pharmacology, Charles University Prague, Albertov 4, 12800 Prague, Czech Republic.
authors.forename: Svatopluk
authors.initials: S
authors.lastname: Světlík
authors.forename: Karolína
authors.initials: K
authors.lastname: Hronová
authors.forename: Hana
authors.initials: H
authors.lastname: Bakhouche
authors.forename: Olga
authors.initials: O
authors.lastname: Matoušková
authors.forename: Ondřej
authors.initials: O
authors.lastname: Slanař
mesh_terms: D015415:Biomarkers / Q000097:blood; D059350:Chronic Pain / Q000097:blood / Q000235:genetics; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods*
chemical_list: D015415:Biomarkers; D016207:Cytokines