title: Ultrasonic irradiation assisted efficient regioselective synthesis of CF3-containing pyrazoles catalyzed by Cu(OTf)2/Et3N.
abstract: BACKGROUND
  Most of the known approaches to the synthesis of CF3-containing organic compounds suffer from serious drawbacks. For example the starting materials required for these methods are rather difficult to obtain, or they are fairly toxic and inconvenient to work with and methods for direct fluorination and trifluoromethylation do not always allow the introduction of the CF3-group at the required position of a molecule.
  
  
  RESULTS
  An efficient and attractive regioselective synthesis of a series of novel pyrazoles containing the trifluromethyl moiety was achieved using Cu(OTf)2/Et3N as an efficient catalytic system under ultrasonic irradiation.
  
  
  CONCLUSIONS
  Cu(OTf)2/Et3N catalyst showed a great advantage over all the investigated catalysts, and the ultrasonic irradiation method offered high yields of pyrazoles in short reaction time compared with classical conditions. gHMBC spectra of the product were used to rationalize the observed regioselectivity.
authors.affiliation: Chemistry Department, Faculty of Science, King Abdulaziz University, North Jeddah, P,O box 80203, Jeddah 21589, Saudi Arabia. chem_org@hotmail.com.
authors.forename: Abdullah S
authors.initials: AS
authors.lastname: Al-Bogami
authors.forename: Tamer S
authors.initials: TS
authors.lastname: Saleh
authors.forename: Hassan M
authors.initials: HM
authors.lastname: Albishri