title: Effects of Moxa Smoke on Monoamine Neurotransmitters in SAMP8 Mice.
abstract: Objectives. To investigate the anti-aging effects of moxa smoke on SAMP8 mice. Methods. Using 2 × 3 factorial design, exposure length (15 or 30 minutes daily), and concentration (low, 5-15 mg/m(3); middle, 25-35 mg/m(3); high, 85-95 mg/m(3)), 70 SAMP8 mice were randomly assigned, n = 10/group, to a model group or one of six moxa smoke groups: L1, L2, M1, M2, H1, or H2. Ten SAMR1 mice were used as normal control. Mice in moxa smoke groups were exposed to moxa smoke at respective concentrations and exposure lengths; the model and normal control mice were not exposed. Cerebral 5-HT, DA, and NE levels were determined using ELISA. Results. Compared to normal control, the model group showed a significant decrease in 5-HT, DA, and NE. Compared to model group, 5-HT and NE were significantly higher in groups L2, M1, and M2 and DA was significantly so in L2 and M1. 5-HT, DA, and NE levels were the highest in group M1 among moxa smoke groups. A marked exposure length × concentration interaction was observed for 5-HT, DA, and NE. Conclusion. Moxa smoke increases monoamine neurotransmitter levels, which varies according to concentration and exposure length. Our finding suggests that the middle concentration of moxa smoke for 15 minutes seems the most beneficial.
authors.affiliation: School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China ; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Huanfang
authors.initials: H
authors.lastname: Xu
authors.forename: Baixiao
authors.initials: B
authors.lastname: Zhao
authors.forename: Yingxue
authors.initials: Y
authors.lastname: Cui
authors.forename: Min Yee
authors.initials: MY
authors.lastname: Lim
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Hongzhu
authors.initials: H
authors.lastname: Guo
authors.forename: Lixing
authors.initials: L
authors.lastname: Lao