title: Effect of antiretroviral therapy on inflammatory markers of endothelial dysfunction in HIV treatment-naïve infected patients.
abstract: The aim of this study was to evaluate the effect of antiretroviral therapy on inflammatory markers of endothelial dysfunction in HIV treatment-naïve infected patients. This was a prospective cohort study in HIV treatment-naïve infected patients. The patients were assigned to a untreated group or a treatment group according to the therapeutic strategy received. Patients in the treatment group received efavirenz or lopinavir/ritonavir, each given with zidovudine and lamivudine. HIV RNA, CD4(+) cell count, and the levels of hsCRP, sCD40L, sICAM-1, sVCAM-1, and sE-selectin were measured before and 12 weeks after treatment. Fifty patients were enrolled: 13 in the untreated group and 37 in the treatment group; 48 (96%) completed the follow-up. The mean (± SD) age was 33 ± 9 years, and 38 (79%) were men. The median pretreatment CD4(+) cell counts were 263 cells/ml (IQR 118-341) in the treatment group and 658 cells/ml (IQR 475-887) in the untreated group. In the treatment group, the median serum sVCAM-1 and sICAM-1 levels decreased by a small but significant amount (1,400 and 228 ng/ml, respectively, P<0.05) from before to after the 12 weeks. These levels did not change in the untreated group. Antiretroviral therapy is associated with a decrease in sVCAM-1 and sICAM-1 levels after 12 weeks of treatment.
authors.affiliation: Hospital de Infectología, "La Raza", National Medical Center, IMSS, Mexico City, Mexico. jamatamarin@gmail.com
authors.forename: José A
authors.initials: JA
authors.lastname: Mata-Marín
authors.forename: René
authors.initials: R
authors.lastname: Méndez-Cruz
authors.forename: Carla I
authors.initials: CI
authors.lastname: Arroyo-Anduiza
authors.forename: Luis A
authors.initials: LA
authors.lastname: Mata-Marín
authors.forename: Jesús
authors.initials: J
authors.lastname: Gaytán-Martínez
authors.forename: Juan
authors.initials: J
authors.lastname: Asbún-Bojalil
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D016207:Cytokines / Q000097:blood; D042783:Endothelial Cells / Q000276:immunology* / Q000473:pathology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008297:Male; D011446:Prospective Studies; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D016207:Cytokines