title: Crosstalk between ER stress and immunogenic cell death.
abstract: Preclinical and clinical findings suggest that tumor-specific immune responses may be responsible--at least in part--for the clinical success of therapeutic regimens that rely on immunogenic cell death (ICD) inducers, including anthracyclines and oxaliplatin. The molecular pathways whereby some, but not all, cytotoxic agents promote bona fide ICD remain to be fully elucidated. Nevertheless, a central role for the endoplasmic reticulum (ER) stress response has been revealed in all scenarios of ICD described thus far. Hence, components of the ER stress machinery may constitute clinically relevant druggable targets for the induction of ICD. In this review, we will summarize recent findings in the field of ICD research with a special focus on ER stress mechanisms and their implication for cancer therapy.
authors.affiliation: Université Paris-Sud/Paris XI, Le Kremlin-Bicêtre, France; INSERM, U848, Villejuif, France; Institut Gustave Roussy, Villejuif, France.
authors.forename: Oliver
authors.initials: O
authors.lastname: Kepp
authors.forename: Laurie
authors.initials: L
authors.lastname: Menger
authors.forename: Erika
authors.initials: E
authors.lastname: Vacchelli
authors.forename: Clara
authors.initials: C
authors.lastname: Locher
authors.forename: Sandy
authors.initials: S
authors.lastname: Adjemian
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Isabelle
authors.initials: I
authors.lastname: Martins
authors.forename: Abdul Qader
authors.initials: AQ
authors.lastname: Sukkurwala
authors.forename: Michael
authors.initials: M
authors.lastname: Michaud
authors.forename: Laura
authors.initials: L
authors.lastname: Senovilla
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
mesh_terms: D000818:Animals; D018943:Anthracyclines / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016923:Cell Death / Q000276:immunology*; D004721:Endoplasmic Reticulum / Q000276:immunology*; D059865:Endoplasmic Reticulum Stress / Q000276:immunology*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000532:radiotherapy; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D000077150:Oxaliplatin
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin
keywords: ATP; Anthracyclines; Apoptosis; Calcium; Calreticulin; PERK