title: Cronkhite-Canada syndrome associated with serrated adenoma and malignant polyp: a case report and a literature review of 13 cronkhite-Canada syndrome cases in Korea.
abstract: Cronkhite-Canada syndrome (CCS) is a rare nonfamilial polyposis syndrome characterized by epithelial disturbances both in the gastrointestinal tract and in the epidermis. The pathologic finding of the polyp is usually a hamartomatous polyp of the juvenile type; however, the possibility of serrated adenoma associated malignant neoplasm was reported in some Japanese cases. Up till now in South Korea, 13 CCS cases have been reported, but there was no case accompanied by the colon cancer. We report the first case of CCS associated with malignant colon polyp and serrated adenoma in Korea. A 72-year-old male patient who complained of diarrhea and weight loss was presented with both hands and feet nail dystrophy, hyperpigmentation, and alopecia. Endoscopic examination showed numerous hamartomatous polyps from the stomach to the colon. The pathologic results confirmed colon cancer and serrated adenoma. Helicobacter pylori eradication and prednisolone was used. Thus, the authors report this case along with a literature review.
authors.affiliation: Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea.
authors.forename: So Hee
authors.initials: SH
authors.lastname: Yun
authors.forename: Jin Woong
authors.initials: JW
authors.lastname: Cho
authors.forename: Ji Woong
authors.initials: JW
authors.lastname: Kim
authors.forename: Joong Keun
authors.initials: JK
authors.lastname: Kim
authors.forename: Moon Sik
authors.initials: MS
authors.lastname: Park
authors.forename: Na Eun
authors.initials: NE
authors.lastname: Lee
authors.forename: Jae Un
authors.initials: JU
authors.lastname: Lee
authors.forename: Young Jae
authors.initials: YJ
authors.lastname: Lee
keywords: Colonic neoplasms; Helicobacter pylori; Intestinal polyposis; Serrated adenoma