title: Bioactive terpenoids from the Red Sea soft coral Sinularia polydactyla.
abstract: Chemical investigation of an ethyl acetate soluble fraction of Sinularia polydactyla (Ehrenberg) led to the isolation of three known terpenoides, two of them sterols, 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (1), 24-methylcholestane-5-en-3β,25-diol (2), in addition to a cembranoid diterpene, durumolide C (3), for the first time. The cytotoxicity and antimicrobial activities of the ethyl acetate extract and the isolated compounds 1-3 were evaluated in vitro. Durumolide C (3) showed selective cytotoxicity against HepG2 (IC50 1.0 μg/mL), whereas 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (1) showed IC50 of 6.1 and 8.2 μg/mL against Hep2 and HCT human cancer cell lines, respectively.
authors.affiliation: a Department of Pharmacognosy , Cairo University , Giza , Egypt.
authors.forename: El-Sayed A
authors.initials: el-SA
authors.lastname: Aboutabl
authors.forename: Shadia M
authors.initials: SM
authors.lastname: Azzam
authors.forename: Camilia G
authors.initials: CG
authors.lastname: Michel
authors.forename: Nabil M
authors.initials: NM
authors.lastname: Selim
authors.forename: Mohamed F
authors.initials: MF
authors.lastname: Hegazy
authors.forename: Abdel-Hamid A M
authors.initials: AH
authors.lastname: Ali
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Hussein
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001410:Bacillus megaterium / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006094:Gram-Positive Bacteria / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013729:Terpenes