title: TIPdb: a database of anticancer, antiplatelet, and antituberculosis phytochemicals from indigenous plants in Taiwan.
abstract: The unique geographic features of Taiwan are attributed to the rich indigenous and endemic plant species in Taiwan. These plants serve as resourceful bank for biologically active phytochemicals. Given that these plant-derived chemicals are prototypes of potential drugs for diseases, databases connecting the chemical structures and pharmacological activities may facilitate drug development. To enhance the utility of the data, it is desirable to develop a database of chemical compounds and corresponding activities from indigenous plants in Taiwan. A database of anticancer, antiplatelet, and antituberculosis phytochemicals from indigenous plants in Taiwan was constructed. The database, TIPdb, is composed of a standardized format of published anticancer, antiplatelet, and antituberculosis phytochemicals from indigenous plants in Taiwan. A browse function was implemented for users to browse the database in a taxonomy-based manner. Search functions can be utilized to filter records of interest by botanical name, part, chemical class, or compound name. The structured and searchable database TIPdb was constructed to serve as a comprehensive and standardized resource for anticancer, antiplatelet, and antituberculosis compounds search. The manually curated chemical structures and activities provide a great opportunity to develop quantitative structure-activity relationship models for the high-throughput screening of potential anticancer, antiplatelet, and antituberculosis drugs.
authors.affiliation: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
authors.forename: Ying-Chi
authors.initials: YC
authors.lastname: Lin
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Wang
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Jhao-Liang
authors.initials: JL
authors.lastname: Jheng
authors.forename: Jih-Heng
authors.initials: JH
authors.lastname: Li
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Tung
mesh_terms: D000970:Antineoplastic Agents / Q000145:classification* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000145:classification* / Q000627:therapeutic use; D003628:Database Management Systems; D062313:Databases, Pharmaceutical; D010936:Plant Extracts / Q000145:classification* / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000145:classification* / Q000627:therapeutic use; D013624:Taiwan; D014584:User-Computer Interface
chemical_list: D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors