title: Macplocimine A, a new 18-membered macrolide isolated from the filamentous sulfur bacteria Thioploca sp.
abstract: Macplocimine A (1), a rare naturally occurring 18-membered macrolide, was isolated from the marine-derived filamentous sulfur bacteria Thioploca sp. The structure was determined by a combination of spectroscopic techniques, including HRESIMS, 1D and 2D NMR analyses. 1 features a thymine group, which is attached to an aromatic fused 18-membered macrolide ring structure derived from a polyketide synthase biosynthetic pathway.
authors.affiliation: Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Stephanie
authors.initials: S
authors.lastname: Vanner
authors.forename: Wenliang
authors.initials: W
authors.lastname: Wang
authors.forename: Yongchang
authors.initials: Y
authors.lastname: Li
authors.forename: Victor Ariel
authors.initials: VA
authors.lastname: Gallardo
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Magarvey
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D013057:Spectrum Analysis; D041962:Thiotrichaceae / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides