title: Biological implications and regulatory mechanisms of long-range chromosomal interactions.
abstract: Development of high-throughput sequencing-based methods has enabled us to examine nuclear architecture at unprecedented resolution, allowing further examination of the function of long-range chromosomal interactions. Here, we review methods used to investigate novel long-range chromosomal interactions and genome-wide organization of chromatin. We further discuss transcriptional activation and silencing in relation to organization and positioning of gene loci and regulation of chromatin organization through protein complexes and noncoding RNAs.
authors.affiliation: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Zong
authors.initials: Z
authors.lastname: Wei
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.forename: Fan
authors.initials: F
authors.lastname: Gao
authors.forename: Wen-Hsuan
authors.initials: WH
authors.lastname: Chang
authors.forename: Woojin
authors.initials: W
authors.lastname: An
authors.forename: Gerhard A
authors.initials: GA
authors.lastname: Coetzee
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Wange
authors.initials: W
authors.lastname: Lu
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D002877:Chromosomes, Human; D015894:Genome, Human; D057166:High-Throughput Screening Assays; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D034882:Lamins / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000378:metabolism; D014158:Transcription, Genetic; D014178:Translocation, Genetic; D049951:X Chromosome Inactivation
chemical_list: D034882:Lamins
keywords: Chromatin; Chromatin Regulation; Chromatin Structure; Chromosome Conformation Capture; Nuclear Organization; Nuclear Structure