title: Assessing the biocompatibility of a dental composite product.
abstract: OBJECTIVE
  The purpose of the study was to assess the biocompatibility of a composite material considering the reaction caused at the implant site during 21 days by daily observing the subjects' behavior as well as by macroscopic examination and histological examination upon expiry of the testing period.
  
  
  METHODS
  We performed the tolerance test by implant of the composite material Dualcim. The implant test was made on two species of lab animals, Guinea pigs and Wistar rats in two versions: subcutaneous implant and intramuscular÷perimuscular implant.
  
  
  RESULTS
  After a 21 days period, when the implant was in direct contact with the tissue, no change of the shape and consistency, color or surface of the implant occurred. Around the implants, the biocompatibility was kept under physiological limits.
  
  
  CONCLUSIONS
  The product, in the structure and shape presented, could be easily placed under good conditions, both at the level of the subcutaneous tissue and at inter-muscular level. In case of both species and in all subjects, the histological exam proved a favorable development of the relationship between the implant body and the placing site.
authors.affiliation: Carol Davila University of Medicine and Pharmacy, Bucharest.
authors.forename: D
authors.initials: D
authors.lastname: Pătroi
authors.forename: M
authors.initials: M
authors.lastname: Gociu
authors.forename: Cristina
authors.initials: C
authors.lastname: Prejmerean
authors.forename: Loredana
authors.initials: L
authors.lastname: Colceriu
authors.forename: Laura
authors.initials: L
authors.lastname: Silaghi Dumitrescu
authors.forename: Marioara
authors.initials: M
authors.lastname: Moldovan
authors.forename: V
authors.initials: V
authors.lastname: Naicu
mesh_terms: D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate / Q000009:adverse effects; D003188:Composite Resins / Q000009:adverse effects*; D003238:Connective Tissue / Q000187:drug effects; D003764:Dental Materials / Q000009:adverse effects*; D006168:Guinea Pigs; D008297:Male; D008422:Materials Testing; D018482:Muscle, Skeletal / Q000187:drug effects; D010895:Pit and Fissure Sealants / Q000009:adverse effects*; D011092:Polyethylene Glycols / Q000009:adverse effects; D011109:Polymethacrylic Acids / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects
chemical_list: D003188:Composite Resins; D003764:Dental Materials; D010895:Pit and Fissure Sealants; D011109:Polymethacrylic Acids; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate