title: Unicryptal gallbladder adenomas in a patient with Gardner's syndrome.
abstract: Gardner's syndrome occurs when mutation of the adenomatous polyposis coli gene is associated with extra-intestinal manifestations in addition to colorectal adenomas. Only eleven cases of gallbladder adenoma in Gardner's syndrome have been previously reported in the literature. We report a case of Gardner's syndrome in which multiple adenomas are associated with unicryptal adenomas. The lesion showed cytoplasmic and nuclear expression of β-catenin. The identification of multiple fully formed and unicryptal adenomas in the gallbladder are suggestive of Gardner's syndrome, and these patients require further investigation and follow up.
authors.affiliation: Department of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. joanne.horne@uhs.nhs.uk
authors.forename: Joanne
authors.initials: J
authors.lastname: Horne
authors.forename: Eleanor
authors.initials: E
authors.lastname: Jaynes
authors.forename: Norman
authors.initials: N
authors.lastname: Carr
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D005706:Gallbladder Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D005736:Gardner Syndrome / Q000235:genetics / Q000473:pathology*; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009154:Mutation; D010641:Phenotype; D051176:beta Catenin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D051176:beta Catenin
keywords: Adenoma; Familial adenomatous polyposis; Gallbladder; Gardner's syndrome; Unicryptal