title: Copper-mediated direct aryl C-H cyanation with azobisisobutyronitrile via a free-radical pathway.
abstract: An unprecedented protocol for the copper-mediated direct cyanation of aryl C-H by employing 2,2'-azobisisobutyronitrile (AIBN) as a free radical "CN" source is presented. The protocol not only provides a more efficient pathway for the synthesis of aryl nitriles in terms of the yields and the loading amount of copper salts but also, more importantly, represents a novel strategy for aryl C-H cyanation via a CN free-radical mechanism as compared to the CN anion-participating protocols often reported.
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.forename: Peng-Tang
authors.initials: PT
authors.lastname: Liu
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Li
authors.forename: Fu-She
authors.initials: FS
authors.lastname: Han