title: A cascade coupling strategy for one-pot total synthesis of β-carboline and isoquinoline-containing natural products and derivatives.
abstract: Multi-birds with one stone: A cascade coupling strategy was developed for the synthesis of β-carbolines. The method can direct the synthesis of β-carboline and isoquinoline-containing natural products with high yields. Moreover, this protocol can also be further applied towards the total synthesis of natural products fascaplysin and papaverin (see scheme).
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, PR China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Zhu
authors.forename: Mei-Cai
authors.initials: MC
authors.lastname: Liu
authors.forename: Qun
authors.initials: Q
authors.lastname: Cai
authors.forename: Feng-Cheng
authors.initials: FC
authors.lastname: Jia
authors.forename: An-Xin
authors.initials: AX
authors.lastname: Wu
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010208:Papaverine / Q000138:chemical synthesis / Q000737:chemistry; D000644:Quaternary Ammonium Compounds; D007212:Indolizines
chemical_list: D001688:Biological Products; D002243:Carbolines; D007211:Indoles; D007546:Isoquinolines; D010208:Papaverine; C069346:fascaplysine; D000644:Quaternary Ammonium Compounds; D007212:Indolizines
keywords: CH coupling; carboline; cascade reactions; isoquinoline; natural products