title: Comparative study of the ocular efficacy and safety of diclofenac sodium (0.1%) ophthalmic solution with that of ketorolac tromethamine (0.5%) ophthalmic solution in patients with acute seasonal allergic conjunctivitis.
abstract: BACKGROUND
  Seasonal allergic conjunctivitis (SAC) is the most common and most prevalent of allergic disorders which afflict the ocular surface. Of the several treatments available, ophthalmic non-steroidal anti-inflammatory drugs, are generally very safe and tolerable.
  
  
  OBJECTIVE
  The aim of this study is to compare the ocular efficacy and safety of diclofenac sodium (0.1%) ophthalmic solution with that of ketorolac tromethamine (0.5%) ophthalmic solution in patients with acute SAC.
  
  
  METHODS
  Sixty patients with signs and symptoms of SAC were evaluated in an open, randomized, parallel group study. The principle symptoms (ocular itching, burning, discharge, photophobia) and signs (ocular inflammation, lid edema, chemosis, conjunctival mucous, keratitis) were evaluated.
  
  
  METHODS
  Patients were randomized into two groups of 30 each. Patients in group A received one drop of diclofenac sodium 0.1% and patients in group B received ketorolac tromethamine 0.5% in both the eyes four times a day for fourteen days. Evaluations were performed at day 0, 3, 7 and 14 of the therapy. At each visit, the signs and symptoms were rated using a scale from 0-3 (mild-1, moderate-2 and severe-3).
  
  
  RESULTS
  Significant clinical and statistical reductions in signs and symptoms from baseline were observed in both groups. Diclofenac sodium 0.1% was superior to ketorolac tromethamine 0.5% in reducing ocular itching (P < 0.05) and ocular inflammation (P < 0.05), at the final examination.
  
  
  CONCLUSIONS
  Diclofenac sodium showed statistically significant better results at day 3 and 7 compared to ketorolac.
authors.affiliation: Department of Pharmacology, M.M.Institute of Medical Sciences and Research, Mullana Ambala, Haryana, India.
authors.forename: Navdeep
authors.initials: N
authors.lastname: Dehar
authors.forename: Anita
authors.initials: A
authors.lastname: Gupta
authors.forename: Gursatinder
authors.initials: G
authors.lastname: Singh
keywords: Allergic conjunctivitis; diclofenac sodium ophthalmic solution; ketorolac tromethamine ophthalmic solution