title: Determination of the antigenotoxic potencies of some luteolin derivatives by using a eukaryotic cell system, Saccharomyces cerevisiae.
abstract: In this study, we aimed to examine the mutagenic and antimutagenic potencies of three luteolin derivatives (luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide) by using a eukaryotic cell system, Saccharomyces cerevisiae (RS112). In the antimutagenicity assays, these luteolin derivatives showed antimutagenic effects in deletion and intrachromosomal recombination events against ethyl methanesulfonate and acridine mutagen agents. In deletion events, the highest inhibition rates for luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against ethyl methanesulfonate were 57.6%, 58.3% and 62.5%, respectively. Likewise, the highest inhibition rates for luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against acridin were 21.8%, 22.4% and 23.6%, respectively. Our findings showed that these luteolin derivatives have stronger antimutagenic properties against ethyl methanesulfonate compared to the acridine mutagen agent.
authors.affiliation: Agri Ibrahim Cecen University, Central Research and Application Laboratories, Agri TR-04100, Turkey.
authors.forename: Furkan
authors.initials: F
authors.lastname: Orhan
authors.forename: Medine
authors.initials: M
authors.lastname: Gulluce
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozkan
authors.forename: Lokman
authors.initials: L
authors.lastname: Alpsoy
mesh_terms: D016587:Antimutagenic Agents / Q000737:chemistry* / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects; D047311:Luteolin / Q000737:chemistry* / Q000494:pharmacology*; D009153:Mutagens / Q000633:toxicity*; D011995:Recombination, Genetic / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics; D017384:Sequence Deletion / Q000187:drug effects
chemical_list: D016587:Antimutagenic Agents; D009153:Mutagens; D047311:Luteolin