title: Comparison of the effects of desflurane and propofol anesthesia on the inflammatory response and s100β protein during coronary artery bypass grafting.
abstract: Cardiopulmonary bypass (CPB) contributes to the secretion of anti-inflammatory cytokines that mediate the inflammatory response observed during open heart surgery. In addition to many factors, type of anesthesia management affects immune response and central nervous system in cardiac surgery. The aim of this study was to assess the effect of propofol versus desflurane anesthesia on systemic immune modulation and central nervous system on patients undergoing coronary artery bypass grafting. Forty patients undergoing elective coronary artery bypass graft surgery with CPB were included in this prospective randomized study. Patients were allocated to receive propofol (n = 20) or desflurane (n = 20) for maintenance of anesthesia. The blood samples for IL-6, IL-8, TNF-α, and S100β were drawn just prior to the operation before the induction of anesthesia, second before cardiopulmonary bypass, third after CPB, fourth 4 h postoperatively at the ICU. Major finding in our study is that S100β levels were lower in propofol group when compared to desflurane anesthesia. And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6. Propofol is more preferable in terms of S100β for anesthetic management for CABG.
authors.affiliation: Department of Anesthesia and Reanimation, Faculty of Medicine, Afyon Kocatepe University, Ali Çetinkaya kampusü, Afyon-İzmir Karayolu8.km, 03200, Afyonkarahisar, Turkey, elifbaki1973@mynet.com.
authors.forename: Elif Doğan
authors.initials: ED
authors.lastname: Baki
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aldemir
authors.forename: Serdar
authors.initials: S
authors.lastname: Kokulu
authors.forename: Halit Buğra
authors.initials: HB
authors.lastname: Koca
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Ela
authors.forename: Remziye Gül
authors.initials: RG
authors.lastname: Sıvacı
authors.forename: Nilgün Kavrut
authors.initials: NK
authors.lastname: Öztürk
authors.forename: Mustafa
authors.initials: M
authors.lastname: Emmiler
authors.forename: Fahri
authors.initials: F
authors.lastname: Adalı
authors.forename: Hanife
authors.initials: H
authors.lastname: Uzel
mesh_terms: D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000627:therapeutic use; D018686:Anesthetics, Intravenous / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002490:Central Nervous System / Q000187:drug effects; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D000077335:Desflurane; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000627:therapeutic use*; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; C508606:CXCL8 protein, human; D002316:Cardiotonic Agents; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D014409:Tumor Necrosis Factor-alpha; D000077335:Desflurane; D007530:Isoflurane; D015742:Propofol