title: Chemotherapy and drug resistance status of malaria parasite in northeast India.
abstract: India reports the highest number of malaria cases in Southeast Asia, of which Plasmodium falciparum contribute more than half of the cases every year. North eastern states of India contribute only 3.96% of country's population but account for >10% of total reported malaria cases, 11% of Plasmodium falciparum cases and 20% of malaria related deaths annually. In India, chloroquine resistance was reported for the first time from northeast region and since then chloroquine treatment failure is being reported from many parts of the region. Increased chloroquine treatment failure has led to change of the drug policy to artemisinin combination therapy as first line of malaria treatment in the region. However, replacing chloroquine to artemisinin combination therapy has not shown significant difference in the overall malaria incidence in the region. The present review addresses the current malaria situation of northeastern region of India in the light of antimalarials drug resistance.
authors.affiliation: Division of Medical Entomology, Defence Research Laboratory, Tezpur, Assam, India. digantagos@yahoo.co.in
authors.forename: Diganta
authors.initials: D
authors.lastname: Goswami
authors.forename: Indra
authors.initials: I
authors.lastname: Baruah
authors.forename: Sunil
authors.initials: S
authors.lastname: Dhiman
authors.forename: Bipul
authors.initials: B
authors.lastname: Rabha
authors.forename: Vijay
authors.initials: V
authors.lastname: Veer
authors.forename: Lokendra
authors.initials: L
authors.lastname: Singh
authors.forename: Dhirendra Kumar
authors.initials: DK
authors.lastname: Sharma
mesh_terms: D000818:Animals; D000852:Anopheles; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use; D018432:Drug Resistance, Multiple / Q000235:genetics; D004359:Drug Therapy, Combination; D006801:Humans; D007194:India / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology; D016780:Malaria, Vivax / Q000188:drug therapy* / Q000453:epidemiology; D010963:Plasmodium falciparum / Q000187:drug effects; D010966:Plasmodium vivax / Q000187:drug effects; D011803:Quinine / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D002738:Chloroquine; C031327:artemisinin; D011803:Quinine