title: Survival after burn in a sub-Saharan burn unit: challenges and opportunities.
abstract: BACKGROUND
  Burns are among the most devastating of all injuries and a major global public health crisis, particularly in sub-Saharan Africa. In developed countries, aggressive management of burns continues to lower overall mortality and increase lethal total body surface area (TBSA) at which 50% of patients die (LA50). However, lack of resources and inadequate infrastructure significantly impede such improvements in developing countries.
  
  
  METHODS
  This study is a retrospective analysis of patients admitted to the burn center at Kamuzu Central Hospital in Lilongwe, Malawi between June 2011 and December 2012. We collected information including patient age, gender, date of admission, mechanism of injury, time to presentation to hospital, total body surface area (TBSA) burn, comorbidities, date and type of operative procedures, date of discharge, length of hospital stay, and survival. We then performed bivariate analysis and logistic regression to identify characteristics associated with increased mortality.
  
  
  RESULTS
  A total of 454 patients were admitted during the study period with a median age of 4 years (range 0.5 months to 79 years). Of these patients, 53% were male. The overall mean TBSA was 18.5%, and average TBSA increased with age--17% for 0-18 year olds, 24% for 19-60 year olds, and 41% for patients over 60 years old. Scald and flame burns were the commonest mechanisms, 52% and 41% respectively, and flame burns were associated with higher mortality. Overall survival in this population was 82%; however survival reduced with increasing age categories (84% in patients 0-18 years old, 79% in patients 19-60 years old, and 36% in patients older than 60 years). TBSA remained the strongest predictor of mortality after adjusting for age and mechanism of burn. The LA50 for this population was 39% TBSA.
  
  
  CONCLUSIONS
  Our data reiterate that burn in Malawi is largely a pediatric disease and that the high burn mortality and relatively low LA50 have modestly improved over the past two decades. The lack of financial resources, health care personnel, and necessary infrastructure will continue to pose a significant challenge in this developing nation. Efforts to increase burn education and prevention in addition to improvement of burn care delivery are imperative.
authors.affiliation: Department of Surgery, University of North Carolina, United States.
authors.forename: Anna F
authors.initials: AF
authors.lastname: Tyson
authors.forename: Laura P
authors.initials: LP
authors.lastname: Boschini
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Kiser
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Samuel
authors.forename: Steven N
authors.initials: SN
authors.lastname: Mjuweni
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Cairns
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Charles
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001830:Body Surface Area; D002053:Burn Units / Q000706:statistics & numerical data; D002056:Burns / Q000209:etiology / Q000401:mortality* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay; D016015:Logistic Models; D008295:Malawi / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017678:Sex Distribution; D016019:Survival Analysis; D055815:Young Adult
keywords: Burns; Injury; LA50; Lethal dose total body surface area; Malawi; Sub-Saharan Africa