title: Gas chromatographic mass analysis and further pharmacological actions of Cymbopogon proximus essential oil.
abstract: The present study reports Gas chromatographic mass analysis (GC-MS) as well as important biological activities of Cymbopogon proximus essential oil. The chemical composition of the essential oil of Cymbopogon proximus was investigated by GC-MS. Furthermore, the effects of Cymbopogon proximus essential oil on the cardiac parasympathetic ganglia in rats, the intra-tracheal pressure in guinea-pigs and on carrageenan-induced inflammation in the rats paw, were studied. The GC-MS study led to the identification of 22 components with Piperitone representing (73.81%), Elemol (9.32%), alpha-Eudesmol (5.21%) and alpha-Terpineol (3.01%) of the oils composition. The percentage protective effect of the oil on the vagus-induced bradycardia in rats was 90.1±3.1%, which represents a significant protection. As for the effect of Cymbopogon oil on bronchoconstrictors-induced increase in intra-tracheal pressure in guinea-pigs, the oil antagonized the actions of 5-HT and histamine by 80±3.7 and 93±8.3%, respectively. Pharmacological investigations using Cymbopogon oil revealed its inherent ability to possess a bronchodilator activity mediated via blockade of both histamine and serotonin receptors. It possessed a significant ganglionic blocking action and a limited anti-inflammatory activity that seemed to involve blockade of histamine and serotonin receptors in the rats' paws.
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: A M
authors.initials: AM
authors.lastname: Al-Taweel
authors.forename: G A
authors.initials: GA
authors.lastname: Fawzy
authors.forename: S
authors.initials: S
authors.lastname: Perveen
authors.forename: K E H
authors.initials: KE
authors.lastname: El Tahir
mesh_terms: D000818:Animals; D031743:Cymbopogon / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009822:Oils, Volatile / Q000032:analysis* / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
chemical_list: D009822:Oils, Volatile; D012701:Serotonin