title: Neonatal sepsis due to coagulase-negative staphylococci.
abstract: Neonates, especially those born prematurely, are at high risk of morbidity and mortality from sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and immaturity of the innate immune system, put these infants at greater risk of developing infection. Although advanced neonatal care enables us to save even the most preterm neonates, the very interventions sustaining those who are hospitalized concurrently expose them to serious infections due to common nosocomial pathogens, particularly coagulase-negative staphylococci bacteria (CoNS). Moreover, the health burden from infection in these infants remains unacceptably high despite continuing efforts. In this paper, we review the epidemiology, immunological risk factors, diagnosis, prevention, treatment, and outcomes of neonatal infection due to the predominant neonatal pathogen CoNS.
authors.affiliation: Child and Family Research Institute, 4th Floor, Translational Research Building, 950 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Marchant
authors.forename: Guilaine K
authors.initials: GK
authors.lastname: Boyce
authors.forename: Manish
authors.initials: M
authors.lastname: Sadarangani
authors.forename: Pascal M
authors.initials: PM
authors.lastname: Lavoie
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003030:Coagulase; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000276:immunology*; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D007363:Intensive Care Units, Neonatal; D018805:Sepsis / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D000900:Anti-Bacterial Agents; D003030:Coagulase