title: Peroxisomes: offshoots of the ER.
abstract: Peroxisomes are part of the ubiquitous set of eukaryotic organelles. They are small, single membrane bounded vesicles, specialized in the degradation of very-long-chain fatty acids and in synthesis of myelin lipids. Once considered inconspicuous, recent new insights in the formation and function of peroxisomes have revealed a much more subtle interplay between organelles that warrant a re-evaluation of the historical assignment of peroxisomes as being either autonomous or ER-derived. Peroxisomes acquire their lipids and membrane proteins from the ER, whereas they import their matrix proteins directly from the cytosol. Remarkably, many of its metabolic enzymes and factors controlling peroxisome abundance (fission and inheritance) too are shared with other organelles, stressing interdependence among cellular compartments.
authors.affiliation: Cellular Protein Chemistry, Faculty of Science, Utrecht University, Padualaan 8, NL-3584 CH Utrecht, The Netherlands. a.vanderzand@uu.nl
authors.forename: Adabella
authors.initials: A
authors.lastname: van der Zand
authors.forename: Henk F
authors.initials: HF
authors.lastname: Tabak
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism*; D056890:Eukaryota / Q000166:cytology* / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D020675:Peroxisomes / Q000737:chemistry / Q000378:metabolism*; D015003:Yeasts / Q000166:cytology / Q000378:metabolism
chemical_list: D008565:Membrane Proteins