title: From gastroprotective to ulcerogenic effects of glucocorticoids: role of long-term glucocorticoid action.
abstract: Glucocorticoids may have dual action on the gastric mucosa: gastroprotective and ulcerogenic. In this article, we review the data which suggested that an initial action of endogenous glucocorticoids, including stress-produced ones as well as exogenous glucocorticoids is gastroprotective and consider possible mechanisms of the conversion of physiological gastroprotective action of glucocorticoid hormones to their pathological ulcerogenic effect.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Filaretova
authors.forename: Tatiana
authors.initials: T
authors.lastname: Podvigina
authors.forename: Tatiana
authors.initials: T
authors.lastname: Bagaeva
authors.affiliation: Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg 199034, Russia. filaretovalp@yandex.ru.
authors.forename: Olga
authors.initials: O
authors.lastname: Morozova
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000166:cytology* / Q000187:drug effects* / Q000473:pathology; D005938:Glucocorticoids / Q000009:adverse effects* / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D010913:Pituitary-Adrenal System / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology* / Q000503:physiopathology; D013315:Stress, Psychological / Q000378:metabolism; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids