title: The core-inversible micelles for hydrophilic drug delivery.
abstract: A unique core-inversible micelle (CIM) was formed via PEG(5k)CA8 for hydrophilic drug delivery. An amyloid-fibril-inhibiting water-soluble molecule, congo red (CR), has been loaded into the hydrophilic core of CIMs. The targeting folate-CIMs significantly enhanced the intracellular delivery of hydrophilic CR in a folate receptor-expressing cell line.
authors.affiliation: Department of Pharmacology, SUNY Upstate Cancer Research Institute, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Huang
authors.forename: Changying
authors.initials: C
authors.lastname: Shi
authors.forename: Yu
authors.initials: Y
authors.lastname: Shao
authors.forename: Kit S
authors.initials: KS
authors.lastname: Lam
authors.forename: Juntao
authors.initials: J
authors.lastname: Luo
mesh_terms: D019826:Cholic Acid / Q000737:chemistry*; D003224:Congo Red / Q000737:chemistry; D016503:Drug Delivery Systems; D019073:HT29 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008823:Micelles; D003224:Congo Red; D011092:Polyethylene Glycols; D019826:Cholic Acid