title: Treatment of superior limbic keratoconjunctivitis with topical tacrolimus 0.03% ointment.
abstract: OBJECTIVE
  To report 2 cases of superior limbic keratoconjunctivitis (SLK) treated with topical tacrolimus 0.03% ointment (Protopic; Fujisawa Healthcare).
  
  
  METHODS
  A female patient aged 52 years and a male patient aged 21 years presented with SLK in both eyes. Both patients had previously received several treatments [such as topical steroids and lubrication, contact lenses, silicone punctal plugs, and vitamin A eye drops], with no improvement. Because of poor response to initial management, the authors started treatment with topical tacrolimus 0.03% twice a day. Objective tarsal conjunctiva inflammation, bulbar conjunctiva findings (such as hyperemia and thickening), cornea staining, and subjective symptoms were evaluated.
  
  
  RESULTS
  A week later, both patients were symptomatically better. Four weeks after treatment initiation, the signs of thickened and hyperemic superior conjunctiva, papillary reaction, and punctate keratopathy were almost resolved. Tacrolimus was successfully tapered in both the patients. There were no side effects.
  
  
  CONCLUSIONS
  Topical tacrolimus 0.03% ointment may be considered an additional treatment option for SLK.
authors.affiliation: *Department of Ophthalmology, University Hospital of Heraklion, University of Crete, Crete, Greece; and †OKEBE, Ophthalmology Center of Northern Greece, Thessaloniki, Greece.
authors.forename: George D
authors.initials: GD
authors.lastname: Kymionis
authors.forename: Nektarios E
authors.initials: NE
authors.lastname: Klados
authors.forename: George A
authors.initials: GA
authors.lastname: Kontadakis
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Mikropoulos
mesh_terms: D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007637:Keratoconjunctivitis / Q000188:drug therapy*; D016850:Limbus Corneae; D008297:Male; D008875:Middle Aged; D009824:Ointments; D016559:Tacrolimus / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus