title: Non-invasive prenatal diagnosis from the perspective of a low-resource country.
abstract: Current clinical practice in obstetrics has shifted the paradigm from a conventional prenatal approach based on invasive procedures, risking both fetus and mother, to non-invasive prenatal testing for some fetal conditions via the analysis of cell-free fetal DNA in maternal blood. In the past 15 years, much research has been devoted to refining the methodology for measuring cell-free fetal DNA in maternal circulation and to exploring clinical applications of this technology as a potential tool for prenatal diagnosis. Since the rapid spread around the world of prenatal diagnosis based on cell-free fetal DNA, it is time to start thinking how this cutting-edge technology might influence current practice of obstetrics in low-resource countries.
authors.affiliation: Department of Obstetrics and Perinatology, Instituto Nacional Materno Perinatal, Lima, Peru. walterichard@hotmail.com
authors.forename: Walter
authors.initials: W
authors.lastname: Ventura
authors.forename: Conny
authors.initials: C
authors.lastname: Nazario-Redondo
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sekizawa
mesh_terms: D004247:DNA / Q000097:blood*; D003906:Developing Countries; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D030342:Genetic Diseases, Inborn / Q000175:diagnosis; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*
chemical_list: D004247:DNA
keywords: Cell-free fetal DNA; Low-resource country; Non-invasive prenatal diagnosis