title: Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells.
abstract: Column chromatographic technology was applied to isolate six purified ursane triterpenoids from the calyx of Fragaria ananassa and they were identified on the basis of spectroscopic methods to be ursolic acid (1), pomolic acid (2), 2-oxo-pomolic acid (3), 3-O-acetyl pomolic acid (4), fupenzic acid (5) and euscaphic acid (6). This is the first study in which these compounds have been isolated from the calyx of F. ananassa. Compared to a well-known inhibitor, α-arbutin, compounds 2-6 showed a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin.
authors.affiliation: a Graduate School of Biotechnology, Kyung Hee University , Yongin , 446-701 , Republic of Korea.
authors.forename: Na-Young
authors.initials: NY
authors.lastname: Song
authors.forename: Jin-Gyeong
authors.initials: JG
authors.lastname: Cho
authors.forename: Dongmoon
authors.initials: D
authors.lastname: Im
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Lee
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.forename: Woo-Duck
authors.initials: WD
authors.lastname: Seo
authors.forename: Hee Cheol
authors.initials: HC
authors.lastname: Kang
authors.forename: Youn-Hyung
authors.initials: YH
authors.lastname: Lee
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003470:Culture Media; D031985:Fragaria / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008546:Melanoma, Experimental / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D003470:Culture Media; D008543:Melanins; D010936:Plant Extracts; D014315:Triterpenes