title: Goitre prevalence and epidemiological features in children living in areas with mildly excessive iodine in drinking-water.
abstract: The prevalence of goitre in areas with mildly excessive iodine in drinking-water is still under debate. The aim of the present study was to explore the prevalence of goitre and its epidemiological characteristics in these areas using WHO criteria. To this end, three towns with a median water iodine (MWI) of 150-300 μg/l were selected randomly in Hengshui City of Hebei Province of China, and one town with a MWI of 105 μg/l was chosen as a control. A total of 452 children in the three towns and 120 children in the control town were randomly selected to measure thyroid volume (T vol) by ultrasound. The goitre status of these children was judged using the criteria recommended by the WHO. The overall goitre prevalences in the three towns were 24·6 % (111/452) by age-specific T vol and 33·0 % (149/452) by body surface area (BSA)-adjusted T vol, which were significantly higher than that in the control town by both age-specific T vol (14·0 % (17/120), P= 0·015) and BSA-adjusted T vol (17·5 % (21/120), P= 0·001). Significant differences were found neither in goitre prevalences across sex by both age-specific T vol (P= 0·078) and BSA-adjusted T vol (P= 0·692) nor in that across age group by both BSA-adjusted T vol (P= 0·461) and age-specific T vol (P= 0·183). The present study found a high prevalence of goitre in children living in areas with mildly excessive iodine in drinking-water in Hebei Province. No significant differences were found in goitre prevalences across sex and age group. These results suggest that the T vol reference values recommended by the WHO could be too low for Chinese children.
authors.affiliation: Hebei Province Center for Disease Prevention and Control, No. 97, Huai'an Donglu, Shijiazhuang City, Hebei Province 050021, People's Republic of China.
authors.forename: Shengmin
authors.initials: S
authors.lastname: Lv
authors.affiliation: Hebei Province Center for Disease Prevention and Control, No. 97, Huai'an Donglu, Shijiazhuang City, Hebei Province 050021, People's Republic of China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
authors.affiliation: Hengshui Municipal Center for Disease Control and Prevention, Hengshui City, Hebei Province, People's Republic of China.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Hebei Province Center for Disease Prevention and Control, No. 97, Huai'an Donglu, Shijiazhuang City, Hebei Province 050021, People's Republic of China.
authors.forename: Zhenshui
authors.initials: Z
authors.lastname: Chong
authors.affiliation: Hebei Province Center for Disease Prevention and Control, No. 97, Huai'an Donglu, Shijiazhuang City, Hebei Province 050021, People's Republic of China.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Du
authors.affiliation: Hebei Province Center for Disease Prevention and Control, No. 97, Huai'an Donglu, Shijiazhuang City, Hebei Province 050021, People's Republic of China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Jia
authors.affiliation: Hebei Province Center for Disease Prevention and Control, No. 97, Huai'an Donglu, Shijiazhuang City, Hebei Province 050021, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Hebei Province Center for Disease Prevention and Control, No. 97, Huai'an Donglu, Shijiazhuang City, Hebei Province 050021, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
mesh_terms: D001830:Body Surface Area; D002648:Child; D002681:China / Q000453:epidemiology; D004032:Diet; D060766:Drinking Water / Q000737:chemistry*; D005260:Female; D006042:Goiter / Q000000981:diagnostic imaging / Q000453:epidemiology*; D006801:Humans; D007455:Iodine / Q000008:administration & dosage; D008297:Male; D009752:Nutritional Status; D015995:Prevalence; D012016:Reference Values; D013961:Thyroid Gland / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D014944:World Health Organization
chemical_list: D060766:Drinking Water; D007455:Iodine