title: Vesicle transport and photoreceptor death: fishing for molecular links.
abstract: Intracellular vesicle transport defects can induce retinal degeneration and photoreceptor cell death, but the molecular connections between these processes remains poorly understood. Reporting in Developmental Cell, Nishiwaki et al. (2013) suggest that a vesicle fusion cis-SNARE complex component translates vesicular transport defects into photoreceptor cell apoptosis.
authors.affiliation: Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University of Mainz, Müllerweg 6, 55099 Mainz, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Nagel-Wolfrum
authors.forename: Uwe
authors.initials: U
authors.lastname: Wolfrum
mesh_terms: D000818:Animals; D017209:Apoptosis; D008561:Membrane Fusion; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D017949:Retinal Cone Photoreceptor Cells / Q000473:pathology*; D052067:Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins / Q000378:metabolism*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D052067:Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins