title: Synthesis and characterization of dextrin monosuccinate.
abstract: Reaction conditions, including reaction solvents, reaction time, reaction temperature, and molar ratio of succinic anhydride (SA) to anhydroglucose units (AGU) in dextrin, were investigated for preparing dextrin monosuccinate with high degree of substitution (DS). The results showed the optimum conditions as follows: Solvent, dimethyl sulfoxide; reaction temperature, 50°C; reaction time, 16 h; and molar ratio of SA to AGU in dextrin, 6:1. Under these conditions, the maximum DS reached 2.64. The chemical structure of dextrin monosuccinate was identified using FT-IR and (13)C NMR. The FT-IR data indicated the absorption bands of esters and carbonyl acids at 1726 and 1,574 cm(-1). Signals at 173.13, 171.81, 28.79, and 28.61 ppm in (13)C NMR spectrum were ascribed to carbons in ester, carbonyl acid, and methylene. These data suggest that the prepared dextrin succinate was monoester with functional carbonyl acid groups and could be used in polymer therapy as drug carriers.
authors.affiliation: The State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
authors.forename: Xiuting
authors.initials: X
authors.lastname: Hu
authors.forename: Benxi
authors.initials: B
authors.lastname: Wei
authors.forename: Bao
authors.initials: B
authors.lastname: Zhang
authors.forename: Xueming
authors.initials: X
authors.lastname: Xu
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Jin
authors.forename: Yaoqi
authors.initials: Y
authors.lastname: Tian
mesh_terms: D003912:Dextrins / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013387:Succinic Anhydrides / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D003912:Dextrins; D004337:Drug Carriers; D013387:Succinic Anhydrides; D014867:Water; C031801:succinic anhydride; C013862:caloreen