title: Mechanical ventilation with heated humidifiers: measurements of condensed water mass within the breathing circuit according to ventilatory settings.
abstract: Heated wire humidifiers (HWHs) are widely used to heat and humidify gases during mechanical ventilation. The control strategy implemented on commercial HWHs, based on maintaining constant gas temperature at the chamber outlet, shows weaknesses: humidifying performances depend on environmental temperature and ventilatory settings, and often condensation occurs. Herein, we analyzed in vitro HWH performances focusing on the condensation amount according to ventilatory settings. We used a physical model to define the parameters which mainly influence the HWH performances. In order to investigate the influence of minute volume (MV) and frequency rate (fr) on condensation, the other influencing parameters were kept constant during experiments, and we introduced a novel approach to estimate the condensation. The method, based on measuring the condensed vapor mass (Δm), provided more objective information than the visual-based scale used in previous studies. Thanks to both the control of other influencing factors and the accurate Δm measures, the investigation showed the Δm increase with MV and fr. Substantial condensation after 7 h of ventilation and the influence of MV and fr on Δm (i.e., Δm = 3 g at MV = 1.5 L min(-1) and fr = 8 bpm and Δm = 9.4 g at MV = 8 L min(-1) and fr = 20 bpm) confirm the weaknesses of `single-point temperature' control strategies.
authors.affiliation: Unit of Measurements and Biomedical Instrumentation, Center for Integrated Research, Università Campus Bio-Medico di Roma,Via Álvaro del Portillo, 21, I-00128 Rome, Italy. e.schena@unicampus.it
authors.forename: E
authors.initials: E
authors.lastname: Schena
authors.forename: P
authors.initials: P
authors.lastname: Saccomandi
authors.forename: S
authors.initials: S
authors.lastname: Cappelli
authors.forename: S
authors.initials: S
authors.lastname: Silvestri
mesh_terms: D004867:Equipment Design; D006358:Hot Temperature; D006801:Humans; D006813:Humidity; D012119:Respiration; D012121:Respiration, Artificial / Q000295:instrumentation*; D013997:Time Factors; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water