title: Copper-catalyzed regioselective fluorination of allylic halides.
abstract: Group activity: A novel copper-catalyzed fluorination of internal allylic bromides and chlorides has been developed by using Et3N⋅3 HF as the fluorine source. A functional group (FG) within the substrate is required to achieve the allylic fluorination, and a variety of secondary allylic fluoride compounds can be accessed in good yield with excellent regioselectivity.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
authors.forename: Zuxiao
authors.initials: Z
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Mu
authors.forename: Pinhong
authors.initials: P
authors.lastname: Chen
authors.forename: Guosheng
authors.initials: G
authors.lastname: Liu
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D003300:Copper; C050431:allyl bromide; C023698:allyl chloride
keywords: allylic halides; copper catalysis; fluorination; regioselectivity; synthetic methods