title: Sequential retro-ene arylation reaction of N-alkoxyenamides for the synthesis of tert-alkylamines.
abstract: A sequential retro-ene arylation reaction has been developed for the conversion of N-alkoxyenamides to the corresponding tert-alkylamines in good yields via the nucleophilic addition of a triarylaluminum reagent to an in situ generated N-acylketimine. The reaction is tolerant of a range of functional groups and provides facile access to a series of tert-alkylamines that would be otherwise difficult to access using conventional procedures.
authors.affiliation: Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Syota
authors.initials: S
authors.lastname: Matsuya
authors.forename: Mikako
authors.initials: M
authors.lastname: Tsugawa
authors.forename: Shohei
authors.initials: S
authors.lastname: Sato
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ueda
authors.forename: Okiko
authors.initials: O
authors.lastname: Miyata
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000588:Amines