title: Oral bullous eruption after taking lisinopril--case report and literature review.
abstract: Drug-induced lesions of oral mucosa are well-established side effect of different commonly used drugs. A female patient under treatment for hypertension with an angiotensin-converting enzyme inhibitor (ACE inhibitor), lisinopril, developed blisters and ulcerations on oral mucosa 3 weeks after lisinopril intake. Due to clinical finding drug-induced pemphigus was considered. However, direct and indirect immunofluorescence anal-ysis revealed no autoantibodies that are commonly present in pemphigus while histological study suggested allergic reaction. Lisinopril was discontinued from further therapy and after a month after her first arrival patient has experienced complete remission of the disease. This case raises the question, whether the term pemphigus in drug-induced reactions could be used when immunopathological criteria for pemphigus are not fulfilled.
authors.affiliation: Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia. mbaranov@inet.hr
authors.forename: Marinka
authors.initials: M
authors.lastname: Baričević
authors.forename: Marinka
authors.initials: M
authors.lastname: Mravak Stipetić
authors.forename: Mirna
authors.initials: M
authors.lastname: Situm
authors.forename: Branka
authors.initials: B
authors.lastname: Marinović
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
authors.forename: Denis
authors.initials: D
authors.lastname: Baričević
authors.forename: Božana
authors.initials: B
authors.lastname: Lončar
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000009:adverse effects; D001768:Blister / Q000139:chemically induced* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D017706:Lisinopril / Q000009:adverse effects*; D009059:Mouth Diseases / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D017706:Lisinopril