title: Zuclopenthixol decanoate in pregnancy: successful outcomes in two consecutive offsprings of the same mother.
abstract: BACKGROUND
  Almost all individual antipsychotics are classified into the intermediate pregnancy risk category as no or limited data exist about human pregnancy outcomes. We presented the case of zuclopenthixol decanoate using in two successive pregnancies of the same woman, which had not been published in the available peer-reviewed literature.
  
  
  METHODS
  A middle-age female subject who suffered from schizophrenia received zuclopenthixol decanoate injection during her two consecutive pregnancies. About four and a half months before diagnosis of the first pregnancy (to approximately 3.5 years after psychosis emergence), zuclopenthixol decanoate (400 mg every other week, im injection) was introduced to the treatment protocol (due to previous non-compliance with haloperidol and risperidone). A significant clinical improvement was achieved and the dose during pregnancy was reduced to 200 mg once monthly and maintained to date. In both pregnancies the women gave birth to healthy girls who have been developing normally until now, at their ages of 6 months and of 3.5 years. During pregnancy and after giving birth to children the mothers' psychiatric status and her social functioning were significantly improved and are still stable. Close monitoring of the mother's health, a multidisciplinary approach to both her treatment and the monitoring of pregnancies as well as the complete compliance with the prescribed drug protocol were likely to be crucial for the therapeutic success.
  
  
  CONCLUSIONS
  A favorable outcome of the present case suggests that the zuclopenthixol decanoate is a rational therapeutic option for pregnant women suffering from psychosis when the expected benefit exceed the potential risk, but a definitive evidence for its safety requires large, controlled studies.
authors.affiliation: Psychiatry Clinic, Clinical Centre Kragujevac and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Janjić
authors.forename: Dragan R
authors.initials: DR
authors.lastname: Milovanović
authors.forename: Dejana Ruzić
authors.initials: DR
authors.lastname: Zecević
authors.forename: Dragan
authors.initials: D
authors.lastname: Loncar
authors.forename: Olivera
authors.initials: O
authors.lastname: Laban
authors.forename: Marija
authors.initials: M
authors.lastname: Stepanović
authors.forename: Mirjana
authors.initials: M
authors.lastname: Varjaric
authors.forename: Slobodan
authors.initials: S
authors.lastname: Obradović
authors.forename: Slavica Djukić
authors.initials: SD
authors.lastname: Dejanović
authors.forename: Slobodan
authors.initials: S
authors.lastname: Janković
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003006:Clopenthixol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; C029674:clopenthixol decanoate; D003006:Clopenthixol