title: Chinese herbal dose in ancient and modern times: a comparative study.
abstract: OBJECTIVE
  Appropriate dose guarantees Chinese herb's safety and effectiveness. There are adult dose criteria for Chinese herbs in decoction in the Pharmacopoeia of the People's Republic of China (2010 Edition) at present. But Chinese herbs have been frequently used in much higher doses than the dose criteria. This study has been conducted to test the dependability of the dose criteria.
  
  
  METHODS
  Twenty Chinese herbs were selected as representatives and their adult doses in decoction in Bei Ji Qian Jin Yao Fang, a famous ancient literature, have been reviewed and compared with those in the Pharmacopoeia of the People's Republic of China (2010 Edition).
  
  
  RESULTS
  The adult dose criteria for all these 20 Chinese herbs in the Pharmacopoeia of the People's Republic of China (2010 Edition) haven't covered those in Bei Ji Qian Jin Yao Fang. Furthermore, maximal adult doses in the dose criteria are much lower than those in Bei Ji Qian Jin Yao Fang.
  
  
  CONCLUSIONS
  The dose criteria in the Pharmacopoeia of the People's Republic of China (2010 Edition) are not comprehensive enough. Studying ancient literatures is an effective method to gain precious Chinese herbs' dose data and helps for new dose criteria's establishment in the future.
authors.affiliation: School of Pharmacy, Shanghai University of Chinese Medicine, Shanghai 201203, China. he_shi_min@yahoo.com.cn
authors.forename: Shimin
authors.initials: S
authors.lastname: He
mesh_terms: D002681:China; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations / Q000266:history*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000266:history* / Q000627:therapeutic use; D049674:History, 21st Century; D049690:History, Ancient; D006801:Humans
chemical_list: D004365:Drugs, Chinese Herbal