title: A literature review on the efficacy and safety of botulinum toxin: an injection in post-stroke spasticity.
abstract: BACKGROUND
  A variety of techniques for the management of spasticity have been suggested, including positioning, cryotherapy, splinting and casting, biofeedback, electrical stimulation, and medical management by pharmacological agents, Botulinum toxin A (BTA) is now the pharmacological treatment of choice in focal spasticity. BTA by blocking acetylcholine release at neuromuscular junctions accounts for its therapeutic action to relieve spasticity.
  
  
  METHODS
  A computerized search of Pub Med was carried out to find the latest result about efficacy of BTA in management of post stroke spasticity.
  
  
  RESULTS
  Among 84 articles were found, frothy of them included in this review and divided to lower and upper extremity.
  
  
  CONCLUSIONS
  BTA is a treatment choice in reducing tone and managing post stroke spasticity .
authors.affiliation: Department of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghasemi
authors.forename: Mehri
authors.initials: M
authors.lastname: Salari
authors.forename: Fariborz
authors.initials: F
authors.lastname: Khorvash
authors.forename: Vahid
authors.initials: V
authors.lastname: Shaygannejad
keywords: Botulinum toxin A; spasticity; stroke