title: Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement.
abstract: Diffuse correlation spectroscopy (DCS) uses the temporal fluctuations of near-infrared (NIR) light to measure cerebral blood flow (CBF) non-invasively. Here, we provide a brief history of DCS applications in the brain with an emphasis on the underlying physical ideas, common instrumentation and validation. Then we describe recent clinical research that employs DCS-measured CBF as a biomarker of patient well-being, and as an indicator of hemodynamic and metabolic responses to functional stimuli.
authors.affiliation: ICFO- Institut de Ciències Fotòniques, Mediterranean Technology Park, 08860 Castelldefels, Barcelona, Spain. Electronic address: turgut.durduran@icfo.es.
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015415:Biomarkers; D001921:Brain / Q000033:anatomy & histology*; D002138:Calibration; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D059906:Neuroimaging / Q000295:instrumentation / Q000379:methods*; D010101:Oxygen Consumption / Q000502:physiology; D018570:Risk Assessment; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods*; D013552:Swine
chemical_list: D015415:Biomarkers
keywords: Cerebral blood flow; Cerebral metabolic rate of oxygen extraction; Diffuse correlation spectroscopy; Diffuse optics; Functional neuroimaging; Ischemic stroke; Near-infrared spectroscopy; Neonatalogy; Neurocritical care