title: Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer.
abstract: ω -3 Polyunsaturated fatty acids (PUFAs), mainly present in fish oil, are part of the human diet. Among PUFAs, docosahexaenoic acid (DHA) has received particular attention for its anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. These data suggest that DHA can exert antitumor activity potentially representing an effective adjuvant in cancer chemotherapy. This review is focused on current knowledge supporting the potential use of DHA for the enhancement of the efficacy of anticancer treatments in relation to its ability to enhance the uptake of anticancer drugs, regulate the oxidative status of tumor cells, and inhibit tumor cell invasion and metastasis.
authors.affiliation: Tuscia University, Department of Ecological and Biological Sciences, Largo dell'Università, 01100 Viterbo, Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Merendino
authors.forename: Lara
authors.initials: L
authors.lastname: Costantini
authors.forename: Laura
authors.initials: L
authors.lastname: Manzi
authors.forename: Romina
authors.initials: R
authors.lastname: Molinari
authors.forename: Donatella
authors.initials: D
authors.lastname: D'Eliseo
authors.forename: Francesca
authors.initials: F
authors.lastname: Velotti
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D004281:Docosahexaenoic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000277:Adjuvants, Pharmaceutic; D000970:Antineoplastic Agents; D004281:Docosahexaenoic Acids