title: Angio-suppressive triterpenoids from Ardisia cf. elliptica (subgenus Tinus) on duck (Anas platyrynchos L.) chorioallantoic membrane.
abstract: The dichloromethane extract of the air-dried leaves of Ardisia cf. elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and β-amyrin (1c). Their structures were identified by NMR spectroscopy. Mixtures of the triterpenes (1a-1c) at ratios of 2 : 2 : 1, 2 : 2 : 3 and 1 : 1 : 1 were tested for their angio-suppressive effects on duck chorioallantoic membrane (CAM). All three ratios were found to be effective in restricting inter-capillary length, while 1a-1c (2 : 2 : 1) was most effective in reducing branch point density with 100% CAM viability and embryo survivability, suggesting a high impact angio-suppressive potential of 1a-1c (2 : 2 : 1).
authors.affiliation: Biology Department, School of Science and Engineering, Ateneo de Manila University, Loyola Heights, Quezon City 1108, Philippines. consolacion.ragasa@dlsu.edu.ph
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Raga
authors.forename: Annabelle A
authors.initials: AA
authors.lastname: Herrera
authors.forename: Consolacion Y
authors.initials: CY
authors.lastname: Ragasa
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D031644:Ardisia / Q000737:chemistry*; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D004372:Ducks; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D020533:Angiogenesis Inhibitors; D004365:Drugs, Chinese Herbal; D014315:Triterpenes