title: [The role of radiation and non-radiation factors in the development and progression of acute leukemia in children].
abstract: At 278 ALL and AML patients the kind of hereditary pathology in the family; clinikal-laboratory features and a course of acute leukemia and terms of longevity of children were studied. Degree of integrated pollution of territory (air, water, soil) by heavy metals and radionuclides and also the irradiation doses have been considered. Results which have been received testify about the certain contribution of genetic components and adverse factors of environment in of development of acute leukemia and their course at children. The definition of different leukemogenic factors action on the condition of hemopoietic system gives the chance to generate the abnormally high risk groups of oncological hematological pathologies among the children's population and to improve the diagnostic and treatment-and-prophylactic actions.
authors.forename: V H
authors.initials: VH
authors.lastname: Bebeshko
authors.forename: K M
authors.initials: KM
authors.lastname: Bruslova
authors.forename: O É
authors.initials: OÉ
authors.lastname: Kuznietsova
authors.forename: N M
authors.initials: NM
authors.lastname: Tsvietkova
authors.forename: L O
authors.initials: LO
authors.lastname: Honchar
authors.forename: S M
authors.initials: SM
authors.lastname: Iatsemyrs'kyĭ
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Samson
authors.forename: T I
authors.initials: TI
authors.lastname: Pushkar'ova
mesh_terms: D000293:Adolescent; D047852:Chernobyl Nuclear Accident; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004787:Environmental Pollution / Q000009:adverse effects*; D005260:Female; D006305:Health Status Indicators; D006410:Hematopoiesis / Q000187:drug effects; D006413:Hematopoietic System / Q000187:drug effects* / Q000473:pathology; D040941:Heredity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D008297:Male; D019216:Metals, Heavy / Q000633:toxicity*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D011868:Radioisotopes / Q000633:toxicity*; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D019216:Metals, Heavy; D011868:Radioisotopes