title: Epigenetic mechanisms in fetal origins of health and disease.
abstract: Early life environment predicts future health. The initial precedents and research focus on this concept arose out of historical events. However, this concept continues to be relevant as evidenced by the recent Chinese famine and the evidence of racial disparities in the United States. The latter allows us to introduce the "life course model" and "weathering" as relevant epigenetic phenomena. We then review the molecular components of environmental epigenetics. We subsequently present glucocorticoid receptor biology as a paradigm that involves all of the components. Finally, we suggest that environmental epigenetics are a key component of the future of personalized medicine.
authors.affiliation: Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: Amber
authors.initials: A
authors.lastname: Osborne-Majnik
authors.forename: Qi
authors.initials: Q
authors.lastname: Fu
authors.forename: Robert H
authors.initials: RH
authors.lastname: Lane
mesh_terms: D019175:DNA Methylation / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D005260:Female; D048070:Fetal Nutrition Disorders / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006657:Histones / Q000378:metabolism*; D006801:Humans; D007226:Infant Mortality / Q000208:ethnology; D007231:Infant, Newborn; D035683:MicroRNAs / Q000502:physiology*; D009707:Nucleosomes / Q000502:physiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000502:physiology*; D011965:Receptors, Glucocorticoid / Q000235:genetics; D013217:Starvation
chemical_list: D006657:Histones; D035683:MicroRNAs; D009707:Nucleosomes; D062085:RNA, Long Noncoding; D011965:Receptors, Glucocorticoid