title: Gemcitabine with paclitaxel therapy against mesocolic leiomyosarcoma: a case report.
abstract: A 65-year-old man complained of lower right abdominal pain, and an intra-abdominal mass was identified. An intra-abdominal hemorrhage was discovered during a thorough examination and emergency surgery was performed. The tumor was ruptured and was fragile, making it difficult to perform extirpation; thus, an ileocecal resection was performed. The histopathological diagnosis of the tumor was leiomyosarcoma, and recurrence was observed during the early postoperative period. The patient underwent surgery twice; each time there was a recurrence, but complete resection could not be obtained, and paclitaxel and gemcitabine chemotherapy was performed. A temporary effect was observed, and control of disease progression lasted approximately five months. Standard chemotherapy for leiomyosarcoma has not been established, but this method could become a therapeutic strategy for leiomyosarcoma.
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Fukuoka, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Mizobe
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Akagi
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Ichitaro
authors.initials: I
authors.lastname: Shiratsuchi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Oka
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Kinugasa
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Kozo
authors.initials: K
authors.lastname: Setojima
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirouzu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007890:Leiomyosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008297:Male; D008646:Mesocolon / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D017239:Paclitaxel / Q000008:administration & dosage; D011379:Prognosis; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D017239:Paclitaxel; D000093542:Gemcitabine
keywords: Leiomyosarcoma; chemotherapy; gemcitabine; mesocolic; paclitaxel; recurrence