title: [Relation between parathyroid hormone and cardiovascular risk in patients with vitamin D deficiency].
abstract: OBJECTIVE
  Vitamin D deficiency and parathyroid hormone (PTH) are associated with an increased cardiovascular risk and arterial stiffness. The aim of our study is to compare the cardiovascular risk in subjects with low vitamin D, attending to the PTH concentration, as well as evaluating the response after administration of vitamin D.
  
  
  METHODS
  Prospective study of patients with a concentration of 25(OH)-vitamin D below 30nmol/l. We evaluated vascular risk parameters as blood pressure, arterial stiffness, lipid profile and glucose metabolism. Patients received vitamin D supplements for 3 months, after which the previous parameters were reassessed.
  
  
  RESULTS
  A total of 32 patients were included. Those with PTH over 65pg/ml were older, had worse renal function, higher systolic blood pressure, pulse pressure and arterial stiffness. Treatment with vitamin D showed a statistically significant trend to lower blood pressure and pulse wave velocity.
  
  
  CONCLUSIONS
  The increase in PTH in patients with low vitamin D involves poor control of blood pressure and increased vascular stiffness. Vitamin D replacement shows a tendency to reduce these parameters.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario del Henares, Coslada, Madrid, España. Electronic address: jmanuel.casado@salud.madrid.org.
authors.forename: Jesús
authors.initials: J
authors.lastname: Casado Cerrada
authors.forename: Pedro
authors.initials: P
authors.lastname: Parra Caballero
authors.forename: Lorena
authors.initials: L
authors.lastname: Vega Piris
authors.forename: Carmen
authors.initials: C
authors.lastname: Suárez Fernández
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology*; D003404:Creatinine / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D010865:Pilot Projects; D011446:Prospective Studies; D012306:Risk; D012709:Serum Albumin / Q000032:analysis; D014655:Vascular Resistance; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D002118:Calcium; D003404:Creatinine; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids; D010281:Parathyroid Hormone; D010758:Phosphorus; D012709:Serum Albumin; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Arterial stiffness; Blood pressure; Cardiovascular risk; Hormona paratiroidea; Parathyroid hormone; Presión arterial; Pulse wave velocity; Riesgo cardiovascular; Rigidez arterial; Velocidad onda de pulso; Vitamin D; Vitamina D