title: The impact of chimerism in DNA-based forensic sex determination analysis.
abstract: Sex determination is the most important step in personal identification in forensic investigations. DNA-based sex determination analysis is comparatively more reliable than the other conventional methods of sex determination analysis. Advanced technology like real-time polymerase chain reaction (PCR) offers accurate and reproducible results and is at the level of legal acceptance. But still there are situations like chimerism where an individual possess both male and female specific factors together in their body. Sex determination analysis in such cases can give erroneous results. This paper discusses the phenomenon of chimerism and its impact on sex determination analysis in forensic investigations.
authors.affiliation: Department of Oral Medicine, Oral Diagnosis and Oral Pathology, Faculty of Dentistry, Melaka Manipal Medical College, 75150 Melaka, Malaysia.
authors.forename: Renjith
authors.initials: R
authors.lastname: George
authors.forename: Preethy Mary
authors.initials: PM
authors.lastname: Donald
authors.forename: Sumanth Kumbargere
authors.initials: SK
authors.lastname: Nagraj
authors.forename: Jose Joy
authors.initials: JJ
authors.lastname: Idiculla
authors.forename: Rashid
authors.initials: R
authors.lastname: Hj Ismail
keywords: DNA; chimerism; forensic sciences; polymerase chain reaction; sex determination analysis