title: Incidence of lymphoplasmacytic lymphoma/Waldenström's macroglobulinaemia in Japan and Taiwan population-based cancer registries, 1996-2003.
abstract: Few studies have investigated the incidence rate of lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (LPL/WM) in Asian populations. We assessed the incidence of LPL/WM using data from 13 population-based cancer registries in Japan and data from the Taiwan National Cancer registry. During 1996-2003, a total of 280 new cases of LPL/WM were recorded in Japan and 56 were recorded in Taiwan, with the median age at diagnosis being 73 and 67 years, respectively. The incidence of LPL/WM showed male predominance in both countries. Crude age-specific incidence rates increased sharply with age in both countries, especially in people >65 years. Age-standardized (to the World standard population) incidence rates per 100,000 person-years were 0.043 (0.071 for men and 0.023 for women) and 0.031 (0.041 for men and 0.020 for women) in Japan and Taiwan, respectively. Age-standardized (to the 2,000 US standard population) incidence rates in Japan and Taiwan were lower than rates reported in the literature for Asians living in the United State. A significant increasing trend was observed in the incidence over the period from 1996 to 2003 in Japan alone. This report suggests that both environmental and/or genetic factors may be involved in LPL/WM development.
authors.affiliation: Graduate School of Public Health, Teikyo University, Tokyo, Japan; Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Iwanaga
authors.forename: Chun-Ju
authors.initials: CJ
authors.lastname: Chiang
authors.forename: Midori
authors.initials: M
authors.lastname: Soda
authors.forename: Mei-Shu
authors.initials: MS
authors.lastname: Lai
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Yang
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsuda
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Sobue
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012042:Registries; D017678:Sex Distribution; D013624:Taiwan / Q000453:epidemiology; D008258:Waldenstrom Macroglobulinemia / Q000453:epidemiology*
keywords: Asian population; Waldenström's macroglobulinemia; age-standardized incidence rate; epidemiology; lymphoplasmacytic lymphoma