title: Application of UV spectrophotometric method for easy and rapid estimation of lafutidine in bulk and pharmaceutical formulation.
abstract: BACKGROUND
  The present research work discusses the development of a UV estimation method for lafutidine. Simple, accurate, cost efficient, and reproducible spectrophotometric method has been developed for the estimation of Lafutidine in bulk and pharmaceutical dosage form.
  
  
  METHODS
  The Stock solution was prepared in a mixture of water and methanol (1:1). Further dilutions were made in water.
  
  
  RESULTS
  The drug was determined at maximum wavelength (λmax) 279 nm. Beers law was obeyed in the concentration range of 10-50 μg/ml having line equation y = 0.0100x + 0.035 with correlation coefficient of 0.999. Results of the analysis were validated statistically and by recovery study.
  
  
  CONCLUSIONS
  The result of analysis was validated as per ICH guidelines and this method can be used for the routine analysis of lafutidine formulation.
authors.affiliation: Department of Pharmaceutical Analysis, Genba Sopanrao Moze College of Pharmacy, Wagholi, Pune, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Jadhav
authors.forename: Dinesh
authors.initials: D
authors.lastname: Dhamecha
authors.forename: Amol
authors.initials: A
authors.lastname: Tate
authors.forename: Harshad
authors.initials: H
authors.lastname: Tambe
authors.forename: Mrityunjaya B
authors.initials: MB
authors.lastname: Patil
keywords: Lafutidine; UV spectrophotometry; validation