title: 5-Fluorouracil delivery from a novel three-dimensional micro-device: in vitro and in vivo evaluation.
abstract: A novel three-dimensional biodegradable micro-device using microelectromechanical systems technology was developed for implantable controlled drug delivery. In order to evaluate the effect of monomer composition and molecular weight of poly(lactic-co-glycolic acid) (PLGA) on the drug release, three 5-Fluorouracil loaded micro-devices, made of 50/50, 27 kDa; 50/50, 40 kDa and 75/25 27 kDa PLGA, were prepared and characterized by in vitro and in vivo methods. The in vitro drug release from three micro-devices followed zero-order kinetics, and PLGA micro-device with the higher molecular weight and lactide/glycolide ratio tended to a longer sustained release period. The in vivo release results agreed with the in vitro results and drug release in vivo was faster than that in vitro for each of micro-devices. And three micro-devices showed different tumor inhibition effect in the tumor bearing mice. In addition, the SEM and weight loss experiments showed that PLGA micro-devices with lower molecular weight and lactide/glycolide ratio had faster degradation. These data provided the information for the optimization of the novel three-dimensional biodegradable micro-device to obtain more suitable systems for controlled release and to meet release requirements of different drugs.
authors.affiliation: School of Medicine, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Zheng
authors.forename: Mingyao
authors.initials: M
authors.lastname: Zhou
authors.forename: Chunhui
authors.initials: C
authors.lastname: Du
authors.forename: Sicen
authors.initials: S
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Lu
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D004337:Drug Carriers / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005472:Fluorouracil / Q000008:administration & dosage*; D019344:Lactic Acid / Q000008:administration & dosage; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D055617:Micro-Electrical-Mechanical Systems / Q000379:methods*; D011100:Polyglycolic Acid / Q000008:administration & dosage; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D000964:Antimetabolites, Antineoplastic; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005472:Fluorouracil