title: Endobronchial metastasis in a dog with sarcoma.
abstract: A 3-year-old neutered male Australian Shepherd mix dog presented with metastatic soft tissue sarcoma arising from a primary tumor in the left lumbar fascia. Two separate metastases to the lungs were characterized by neoplasia within bronchiolar walls, which caused obstruction of the bronchiolar lumina and atelectasis of adjacent alveoli, a characteristic feature of endobronchial metastasis. Neoplastic cells of the primary lumbar neoplasm, metastatic pulmonary lesions, and additional widespread metastatic masses identified postmortem were similarly immunoreactive for vimentin, but non-immunoreactive for cytokeratin, cluster of differentiation 18, synaptophysin, chromogranin, and desmin. The present report describes a naturally occurring case of endobronchial metastasis in a dog.
authors.affiliation: Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. pas@colostate.edu
authors.forename: Paula A
authors.initials: PA
authors.lastname: Schaffer
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Weishaar
authors.forename: Sushan
authors.initials: S
authors.lastname: Han
mesh_terms: D000818:Animals; D001984:Bronchial Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D008161:Lumbosacral Region / Q000473:pathology* / Q000601:surgery; D008297:Male; D012509:Sarcoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery / Q000662:veterinary*
keywords: Cancer; canine; endobronchial metastasis; soft tissue sarcoma