title: Tet1 regulates adult hippocampal neurogenesis and cognition.
abstract: DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in embryonic stem cells and neurons in mammals. However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain. Mice lacking Tet1 exhibit impaired hippocampal neurogenesis accompanied by poor learning and memory. In adult neural progenitor cells deficient in Tet1, a cohort of genes involved in progenitor proliferation were hypermethylated and downregulated. Our results indicate that Tet1 is positively involved in the epigenetic regulation of neural progenitor cell proliferation in the adult brain.
authors.affiliation: The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Run-Rui
authors.initials: RR
authors.lastname: Zhang
authors.forename: Qing-Yan
authors.initials: QY
authors.lastname: Cui
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Murai
authors.forename: Yen Ching
authors.initials: YC
authors.lastname: Lim
authors.forename: Zachary D
authors.initials: ZD
authors.lastname: Smith
authors.forename: Shengnan
authors.initials: S
authors.lastname: Jin
authors.forename: Peng
authors.initials: P
authors.lastname: Ye
authors.forename: Luis
authors.initials: L
authors.lastname: Rosa
authors.forename: Yew Kok
authors.initials: YK
authors.lastname: Lee
authors.forename: Hai-Ping
authors.initials: HP
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Zhi-Mei
authors.initials: ZM
authors.lastname: Xu
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Yu-Qiang
authors.initials: YQ
authors.lastname: Ding
authors.forename: Fuchou
authors.initials: F
authors.lastname: Tang
authors.forename: Alexander
authors.initials: A
authors.lastname: Meissner
authors.forename: Chunming
authors.initials: C
authors.lastname: Ding
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Shi
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Xu
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D049109:Cell Proliferation; D003071:Cognition; D019175:DNA Methylation / Q000235:genetics; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000378:metabolism*; D018891:Dentate Gyrus / Q000166:cytology; D005786:Gene Expression Regulation; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006624:Hippocampus / Q000254:growth & development* / Q000378:metabolism*; D008568:Memory; D051379:Mice; D064231:Nestin / Q000378:metabolism; D055495:Neurogenesis / Q000235:genetics; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000172:deficiency / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D064231:Nestin; D011518:Proto-Oncogene Proteins; C540839:TET1 protein, mouse; D049452:Green Fluorescent Proteins