title: Cholesterol metabolism and weight reduction in subjects with mild obstructive sleep apnoea: a randomised, controlled study.
abstract: To evaluate whether parameters of obstructive sleep apnoea (OSA) associate with cholesterol metabolism before and after weight reduction, 42 middle-aged overweight subjects with mild OSA were randomised to intensive lifestyle intervention (N = 23) or to control group (N = 18) with routine lifestyle counselling only. Cholesterol metabolism was evaluated with serum noncholesterol sterol ratios to cholesterol, surrogate markers of cholesterol absorption (cholestanol and plant sterols) and synthesis (cholestenol, desmosterol, and lathosterol) at baseline and after 1-year intervention. At baseline, arterial oxygen saturation (SaO2 ) was associated with serum campesterol (P < 0.05) and inversely with desmosterol ratios (P < 0.001) independently of gender, BMI, and homeostasis model assessment index of insulin resistance (HOMA-IR). Apnoea-hypopnoea index (AHI) was not associated with cholesterol metabolism. Weight reduction significantly increased SaO2 and serum cholestanol and decreased AHI and serum cholestenol ratios. In the groups combined, the changes in AHI were inversely associated with changes of cholestanol and positively with cholestenol ratios independent of gender and the changes of BMI and HOMA-IR (P < 0.05). In conclusion, mild OSA seemed to be associated with cholesterol metabolism independent of BMI and HOMA-IR. Weight reduction increased the markers of cholesterol absorption and decreased those of cholesterol synthesis in the overweight subjects with mild OSA.
authors.affiliation: Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, P.O. BOX 1627, 70211 Kuopio, Finland.
authors.forename: Maarit
authors.initials: M
authors.lastname: Hallikainen
authors.forename: Henri
authors.initials: H
authors.lastname: Tuomilehto
authors.forename: Tarja
authors.initials: T
authors.lastname: Martikainen
authors.forename: Esko
authors.initials: E
authors.lastname: Vanninen
authors.forename: Juha
authors.initials: J
authors.lastname: Seppä
authors.forename: Jouko
authors.initials: J
authors.lastname: Kokkarinen
authors.forename: Jukka
authors.initials: J
authors.lastname: Randell
authors.forename: Helena
authors.initials: H
authors.lastname: Gylling