title: Fronto-temporal interactions in the theta-band during auditory deviant processing.
abstract: Mismatch negativity (MMN) is a negative component of event-related potential (ERP) that reflects auditory deviant detection. Previous studies repeatedly suggested that MMN is generated by the fronto-temporal network. However, it is still unclear how the frontal and temporal areas interact. To verify this, we observed the spatiotemporal pattern of inter-regional functional connectivity using phase synchrony and Granger causality, by analyzing event-related electroencephalograms (EEGs) elicited by standard and deviant tones in an oddball paradigm. Strong theta-band phase synchrony and bidirectional Granger causality were observed between the frontal and temporal areas during the processing of auditory deviants, especially at the temporal interval of MMN. Our results support the hypothesis that fronto-temporal interactions are crucial to the generation of MMN during auditory deviant processing.
authors.affiliation: Department of Biomedical Engineering, College of Health Science, Yonsei University, 234 Maeji-ri, Heungup-myun, Wonju, Gangwon-do, 220-710, Republic of Korea.
authors.forename: Jeong Woo
authors.initials: JW
authors.lastname: Choi
authors.forename: Jong Ku
authors.initials: JK
authors.lastname: Lee
authors.forename: Deokwon
authors.initials: D
authors.lastname: Ko
authors.forename: Gwan-Taek
authors.initials: GT
authors.lastname: Lee
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Jung
authors.forename: Kyung Hwan
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D003265:Contingent Negative Variation / Q000502:physiology*; D003463:Cues; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D010470:Perceptual Masking / Q000502:physiology; D010897:Pitch Discrimination / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*; D013826:Theta Rhythm / Q000502:physiology*
keywords: Event-related potential (ERP); Fronto-temporal interactions; Granger causality (GC); Mismatch negativity (MMN); Phase synchrony (PS)