title: The alteration of copper homeostasis in inflammation induced by lipopolysaccharides.
abstract: Significant changes of copper homeostasis were triggered by lipopolysaccharides, which result in systemic inflammatory response and contribute to hepatic injury. Administration of lipopolysaccharides resulted in the increase of plasma "free" copper and total copper concentrations, whereas, the decrease of "free" copper and total copper contents in liver tissue. Copper-associated proteins were detected and showed a down-regulation of X-linked inhibitor of apoptosis protein, and up-regulation of copper metabolism domain containing 1 and copper transporter 1. The alteration of these proteins would lower the apoptotic threshold. Meanwhile, the increasing of circulation copper might cause oxidative injury through Fenton reaction and contribute to tissue injury. Our findings underscored the possibility that these changes in systemic copper homeostasis might provide a novel insight of the characteristic of the acute phase of inflammatory response and the underlying influence on tissue injury.
authors.affiliation: Second Affiliated Hospital of Shantou University Medical College, Dongxia North Road (Zhu-Xia block), Shantou, Guangdong Province 515041, People's Republic of China. hanyu73@126.com
authors.forename: Ming
authors.initials: M
authors.lastname: Han
authors.forename: Zhexuan
authors.initials: Z
authors.lastname: Lin
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis*; D000818:Animals; D027682:Cation Transport Proteins / Q000096:biosynthesis*; D003300:Copper / Q000378:metabolism*; D000079923:Copper Transporter 1; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D008070:Lipopolysaccharides / Q000633:toxicity*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D015854:Up-Regulation / Q000187:drug effects*; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000096:biosynthesis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C549962:COMMD1 protein, rat; D027682:Cation Transport Proteins; D000079923:Copper Transporter 1; D008070:Lipopolysaccharides; D051636:X-Linked Inhibitor of Apoptosis Protein; D003300:Copper