title: Autologous immune enhancement therapy against an advanced epithelioid sarcoma: A case report.
abstract: Rare types of cancer are often not effectively treated by approaches such as chemotherapy and radio-therapy, although their side-effects persist. Immunotherapy has been gaining attention worldwide with growing examples of its anticancer activity demonstratedin vivo. This case report describes a 35-year-old male who suffered from advanced epithelioid sarcoma and underwent 18 cycles of chemotherapy without any significant response, who suffered adverse effects that caused lung collapse. A notable response was observed following the administration of autologous immune enhancement therapy (AIET), which involves a process of isolation, activation and expansion of natural killer (NK) and T cells, which were obtained from the patient's own (autologous) peripheral blood. With the present data and the response of the patient to AIET, it may be proposed that AIET is beneficial for patients suffering from advanced epithelioid sarcoma without producing adverse effects.
authors.affiliation: Nilai Cancer Institute (NCI) Hospital, Nilai 71800;
authors.forename: Kananathan
authors.initials: K
authors.lastname: Ratnavelu
authors.forename: Baskar
authors.initials: B
authors.lastname: Subramani
authors.forename: Chithra Ramanathan
authors.initials: CR
authors.lastname: Pullai
authors.forename: Kohila
authors.initials: K
authors.lastname: Krishnan
authors.forename: Sheela Devi
authors.initials: SD
authors.lastname: Sugadan
authors.forename: Manjunath Sadananda
authors.initials: MS
authors.lastname: Rao
authors.forename: Abhi
authors.initials: A
authors.lastname: Veerakumarasivam
authors.forename: Xuewen
authors.initials: X
authors.lastname: Deng
authors.forename: Terunuma
authors.initials: T
authors.lastname: Hiroshi
keywords: T cells; advanced epithelioid sarcoma; adverse reactions; autologous immune enhancement therapy; natural killer cells