title: Cortical surface area correlates with STON2 gene Ser307Pro polymorphism in first-episode treatment-naïve patients with schizophrenia.
abstract: BACKGROUND
  Evidence shows that STON2 gene is associated with synaptic function and schizophrenia. This study aims to explore the relationship between two functional polymorphisms (Ser307Pro and Ala851Ser) of STON2 gene and the cortical surface area in first-episode treatment-naïve patients with schizophrenia and healthy controls.
  
  
  RESULTS
  Magnetic resonance imaging of the whole cortical surface area, which was computed by an automated surface-based technique (FreeSurfer), was obtained from 74 first-episode treatment-naïve patients with schizophrenia and 55 healthy controls. Multiple regression analysis was performed to investigate the effect of genotype subgroups on the cortical surface area. A significant genotype-by-diagnosis effect on the cortical surface area was observed. Pro-allele carriers of Ser307Pro polymorphism had larger right inferior temporal surface area than Ser/Ser carriers in the patients with schizophrenia; however, no significant difference was found in the same area in the healthy controls. The Ala851Ser polymorphism of STON2 gene was not significantly associated with the cortical surface area in patients with schizophrenia and healthy controls.
  
  
  CONCLUSIONS
  The present study demonstrated that the functional variant of the STON2 gene could alter cortical surface area on the right inferior temporal and contribute to the pathogenesis of schizophrenia.
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xiang
authors.forename: Jun-Yao
authors.initials: JY
authors.lastname: Wu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Ming-Li
authors.initials: ML
authors.lastname: Li
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Zhuang-Fei
authors.initials: ZF
authors.lastname: Chen
authors.forename: Zong-Ling
authors.initials: ZL
authors.lastname: He
authors.forename: Cao-Hua
authors.initials: CH
authors.lastname: Huang
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Han
authors.forename: Yin-Fei
authors.initials: YF
authors.lastname: Li
authors.forename: Yin
authors.initials: Y
authors.lastname: Lin
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.forename: Ying-Cheng
authors.initials: YC
authors.lastname: Wang
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Ma
authors.forename: Qi-Yong
authors.initials: QY
authors.lastname: Gong
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Xun
authors.initials: X
authors.lastname: Hu
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology; D055815:Young Adult
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; C429267:STON2 protein, human