title: Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus.
abstract: Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.
authors.affiliation: Institute of Cardiology, Catholic University, Largo A. Gemelli, Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Pedicino
authors.forename: Giovanna
authors.initials: G
authors.lastname: Liuzzo
authors.forename: Francesco
authors.initials: F
authors.lastname: Trotta
authors.forename: Ada Francesca
authors.initials: AF
authors.lastname: Giglio
authors.forename: Simona
authors.initials: S
authors.lastname: Giubilato
authors.forename: Francesca
authors.initials: F
authors.lastname: Martini
authors.forename: Francesco
authors.initials: F
authors.lastname: Zaccardi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Scavone
authors.forename: Marco
authors.initials: M
authors.lastname: Previtero
authors.forename: Gianluca
authors.initials: G
authors.lastname: Massaro
authors.forename: Pio
authors.initials: P
authors.lastname: Cialdella
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Cardillo
authors.forename: Dario
authors.initials: D
authors.lastname: Pitocco
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ghirlanda
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D002460:Cell Line; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000276:immunology* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology* / Q000473:pathology; D007333:Insulin Resistance / Q000276:immunology; D050417:Insulin-Secreting Cells / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology