title: Repeated treatment with furazolidone induces multiple cytochrome p450-related activities in chicken liver, but not in rat liver.
abstract: The nitrofuran antimicrobial agent, furazolidone (FZ), is still used in veterinary medicine in some countries in the Middle and Far Eastern countries. The present study aimed to investigate the effects of successive bolus doses of FZ and its metabolite 3-amino-2-oxazolidinone (AOZ) on cytochrome P450 (CYP)-related activities in the livers of rats and chickens. Female Wistar rats and white Leghorn chickens were orally administered FZ once a day for 4 consecutive days. FZ-treated chickens showed an increase in multiple CYP-related activities, however, rats treated with FZ did not show these changes. In chickens, treatment with FZ also induced production of microsomal CYP2C6-like apoprotein. The present study demonstrated that FZ caused a multiple-type induction of CYP-related activities in chickens, but not in rats.
authors.affiliation: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060-0818, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sasaki
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Matumoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ikenaka
authors.forename: Shouta M M
authors.initials: SM
authors.lastname: Nakayama
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ishizuka
authors.forename: Akio
authors.initials: A
authors.lastname: Kazusaka
authors.forename: Shoichi
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000818:Animals; D015153:Blotting, Western / Q000662:veterinary; D002645:Chickens / Q000378:metabolism*; D019363:Cytochrome P-450 CYP1A1 / Q000032:analysis; D019362:Cytochrome P-450 CYP2B1 / Q000032:analysis; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005664:Furazolidone / Q000008:administration & dosage / Q000494:pharmacology*; D006834:Hydrazines / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D023303:Oxazolidinones / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects
chemical_list: D006834:Hydrazines; D023303:Oxazolidinones; D005664:Furazolidone; C000209:3-amino-2-oxazolidinone; C037834:2-hydroxyethylhydrazine; D003577:Cytochrome P-450 Enzyme System; C076307:methoxyresorufin-O-demethylase; D019363:Cytochrome P-450 CYP1A1; D019362:Cytochrome P-450 CYP2B1