title: Topological insulator bismuth selenide as a theranostic platform for simultaneous cancer imaging and therapy.
abstract: Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi2Se3) in in vivo and in vitro system for the first time. We show that Bi2Se3 nanoplates can absorb near-infrared (NIR) laser light and effectively convert laser energy into heat. Such photothermal conversion property may be due to the unique physical properties of topological insulators. Furthermore, localized and irreversible photothermal ablation of tumors in the mouse model is successfully achieved by using Bi2Se3 nanoplates and NIR laser irradiation. In addition, we also demonstrate that Bi2Se3 nanoplates exhibit strong X-ray attenuation and can be utilized for enhanced X-ray computed tomography imaging of tumor tissue in vivo. This study highlights Bi2Se3 nanoplates could serve as a promising platform for cancer diagnosis and therapy.
authors.affiliation: The Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, P R China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: Jiang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Song
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Huang-Hao
authors.initials: HH
authors.lastname: Yang
authors.forename: Dai-Rong
authors.initials: DR
authors.lastname: Cao
authors.forename: Wen-Rong
authors.initials: WR
authors.lastname: Shi
authors.forename: Guo-Nan
authors.initials: GN
authors.lastname: Chen
mesh_terms: D000818:Animals; D001729:Bismuth / Q000737:chemistry*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D046529:Microscopy, Electron, Transmission; D009374:Neoplasms, Experimental / Q000175:diagnosis* / Q000628:therapy*; D012643:Selenium / Q000737:chemistry; D014057:Tomography, X-Ray Computed; D014961:X-Ray Diffraction
chemical_list: D012643:Selenium; D001729:Bismuth