title: Youngest case of an early gastric cancer after successful eradication therapy.
abstract: A 28-year-old woman visited our clinic with a chief complaint of epigastralgia. She had received successful Helicobacter pylori (H. pylori) eradication therapy 5 years before. We repeated esophagogastroduodenoscopy, and a discolored depressed area with reddish spots and converging folds, 20 mm in size, was detected. No atrophic change including intestinal metaplasia or nodular gastritis was seen endoscopically. Two endoscopic biopsies revealed undifferentiated adenocarcinoma. No H. pylori was found, and the (13)C-urea breath test was also negative. Abdominal computed tomography demonstrated no nodal involvement, distant metastasis or fluid collection. She underwent a laparoscopy-assisted distal gastrectomy. Histologically, the resected specimen revealed an early undifferentiated gastric cancer that had invaded deeply into the submucosal layer. Nodal involvement was histologically confirmed. No atrophic change or H. pylori infection was evident histologically. This is the youngest patient ever reported to have developed a node-positive early gastric cancer after eradication of H. pylori.
authors.affiliation: Hironori Konuma, Kuangi Fu, Akihisa Miyazaki, Department of Gastroenterology, Juntendo Univerity Nerima Hospital, Nerima, Tokyo 177-8521, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Konuma
authors.forename: Ichiro
authors.initials: I
authors.lastname: Konuma
authors.forename: Kuangi
authors.initials: K
authors.lastname: Fu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Akihisa
authors.initials: A
authors.lastname: Miyazaki
keywords: Early gastric cancer; Eradication therapy; Helicobacter pylori; Intestinal-type adenocarcinoma; Point of no return theory; Undifferentiated adenocarcinoma