title: Severe immune-mediated drug-induced liver injury linked to ibandronate: a case report.
abstract: Ibandronate is a widely used bisphosphonate with no previously well documented hepatotoxicity. We report the first case of ibandronate-related hepatotoxicity and, to our knowledge, the first case of immune-mediated drug-induced liver injury (DILI) related to bisphosphonates.
authors.affiliation: Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland. Electronic address: nicolas.goossens@hcuge.ch.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Goossens
authors.forename: Laurent
authors.initials: L
authors.lastname: Spahr
authors.forename: Laura
authors.initials: L
authors.lastname: Rubbia-Brandt
mesh_terms: D000305:Adrenal Cortex Hormones; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D000075202:Contraindications; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D000077557:Ibandronic Acid; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy*; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome; D028761:Withholding Treatment
chemical_list: D000305:Adrenal Cortex Hormones; D004164:Diphosphonates; D013256:Steroids; D006886:Hydroxychloroquine; D000077557:Ibandronic Acid
keywords: AIH; ALT; AST; Bisphosphonate; CT; DILI; Drug-induced liver injury; HIV; Ibandronate; LFTs; N; RUCAM; Roussel Uclaf Causality Assessment Method; ULN; alanine aminotransferase; aspartate aminotransferase; auto-immune hepatitis; computed tomography; drug-induced liver injury; human immunodeficiency virus; liver function tests; normal; upper limit of normal