title: First manic episode in a patient with breast cancer.
abstract: Mental disorders occur in as much as 50% of patients with cancer, impairing the oncologic prognosis and quality of life. The diagnostic investigation and treatment planning of this comorbidity impose a clinical challenge once complications related to the neoplasm, such as brain metastasis and paraneoplastic syndromes, must be excluded. In addition, psychotropic medications may interfere with oncologic treatment. We report the case of a 39-year-old female patient who presented with a first episode of psychotic mania after having been recently diagnosed with breast cancer. Also, we present a literature review of this comorbidity and point out a possible pathophysiological link between the two diseases.
authors.affiliation: Psychiatric Unit, Hospital São Paulo, Federal University of São Paulo, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in at Risk Mental States (PRISMA), Federal University of São Paulo, São Paulo, Brazil. Electronic address: asevedo@unifesp.br.
authors.forename: Elson
authors.initials: E
authors.lastname: Asevedo
authors.forename: Elisa
authors.initials: E
authors.lastname: Brietzke
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Chaves
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000209:etiology*; D001943:Breast Neoplasms / Q000523:psychology*; D018270:Carcinoma, Ductal, Breast / Q000523:psychology*; D003987:Dibenzothiazepines / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000069348:Quetiapine Fumarate; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D018692:Antimanic Agents; D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D014635:Valproic Acid
keywords: Bipolar disorder; Breast neoplasms; Comorbidity; Psychotic disorders