title: Remote control of macrophage production by cancer.
abstract: The communication between tumor and host cells involves signals that act across extended distances in the body. Recent evidence indicates that the hormone angiotensin II is overproduced by lung adenocarcinoma to remotely expand bone marrow-derived hematopoietic stem cells. This process amplifies the supply of tumor-associated macrophages, which promote disease progression.
authors.affiliation: Center for Systems Biology; Massachusetts General Hospital and Harvard Medical School; Boston, MA USA.
authors.forename: Virna
authors.initials: V
authors.lastname: Cortez-Retamozo
authors.forename: Camilla
authors.initials: C
authors.lastname: Engblom
authors.forename: Mikael J
authors.initials: MJ
authors.lastname: Pittet
keywords: Angiotensin II; NSCLC; cancer; hematopoietic stem cell; lung adenocarcinoma; macrophage; monocyte