title: A pair of sulfonated diarylheptanoid epimers from Kaempferia galanga.
abstract: OBJECTIVE
  To discover new bioactive constituents from Kaempferia galanga L. (Zingiberaceae).
  
  
  METHODS
  The extract of K. galanga was divided into the chloroform and water-soluble portions. The latter fraction was successively subjected to column chromatography over a D101 macroporous adsorption resin, MCI, Sephadex LH-20, and preparative HPLC to obtain two compounds.
  
  
  RESULTS
  Two novel sulfonated diarylheptanoid epimers, namely kaempsulfonic acids A (1) and B (2), were isolated from the rhizomes of K. galanga. Their structures were established by analysis of spectroscopic data. The absolute configurations of 1 and 2 were determined by the comparison of experimental electronic circular dichroism (ECD) spectroscopy and the computational calculation method, combined with Mo2(OAc)4 induced circular dichroism (ICD).
  
  
  CONCLUSIONS
  The isolates 1 and 2 are new compounds and their absolute configurations were determined for the first time.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Fang-Lin
authors.initials: FL
authors.lastname: Wang
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Luo
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Wang
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D002851:Chromatography, High Pressure Liquid; D036381:Diarylheptanoids / Q000737:chemistry* / Q000302:isolation & purification; D007536:Isomerism; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D027343:Rhizome / Q000737:chemistry; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D036381:Diarylheptanoids; D010936:Plant Extracts