title: Intra-prosthetic breast MR virtual navigation: a preliminary study for a new evaluation of silicone breast implants.
abstract: OBJECTIVE
  To assess the contribute of intra-prosthetic MRI virtual navigation for evaluating breast implants and detecting implant ruptures.
  
  
  METHODS
  Forty-five breast implants were evaluated by MR examination. Only patients with a clinical indication were assessed. A 1.5-T device equipped with a 4-channel breast coil was used by performing axial TSE-T2, axial silicone-only, axial silicone suppression and sagittal STIR images. The obtained dicom files were also analyzed by using virtual navigation software. Two blinded radiologists evaluated all MR and virtual images. Eight patients for a total of 13 implants underwent surgical replacement. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for both imaging strategies.
  
  
  RESULTS
  Intra-capsular rupture was diagnosed in 13 out of 45 (29%) implants by using MRI. Basing on virtual navigation, 9 (20%) cases of intra-capsular rupture were diagnosed. Sensitivity, specificity, accuracy, PPV and NPV values of 100%, 86%, 89%, 62% and 100%, respectively, were found for MRI. Virtual navigation increased the previous values up to 100%, 97%, 98%, 89% and 100%.
  
  
  CONCLUSIONS
  Intra-prosthetic breast MR virtual navigation can represent an additional promising tool for the evaluation of breast implants being able to reduce false positives and to provide a more accurate detection of intra-capsular implant rupture signs.
authors.affiliation: DIM - Interdisciplinary Department of Medicine - Section of Diagnostic Imaging- "Aldo Moro" University of Bari Medical School -Piazza Giulio Cesare 11 - 70124 Bari, Italy. Electronic address: marco.moschetta@uniba.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Moschetta
authors.forename: Michele
authors.initials: M
authors.lastname: Telegrafo
authors.forename: Giulia
authors.initials: G
authors.lastname: Capuano
authors.forename: Leonarda
authors.initials: L
authors.lastname: Rella
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Scardapane
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Angelelli
authors.forename: Amato Antonio
authors.initials: AA
authors.lastname: Stabile Ianora
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology* / Q000601:surgery*; D018427:Breast Implants / Q000009:adverse effects*; D019544:Equipment Failure Analysis; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008875:Middle Aged; D010865:Pilot Projects; D011475:Prosthesis Failure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012828:Silicones / Q000009:adverse effects; D025321:Surgery, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome; D014584:User-Computer Interface
chemical_list: D012828:Silicones
keywords: Breast; Imaging; MRI; Prosthesis; Virtual