title: Absorbance correction method for estimation of telmisartan and metoprolol succinate in combined tablet dosage forms.
abstract: OBJECTIVE
  The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of telmisartan and metoprolol succinate in combined tablet dosage form.
  
  
  METHODS
  The method is based on the absorbance correction equations for analysis of both the drugs using methanol as solvent. Telmisartan has absorbance maxima at 296 nm and metoprolol succinate has absorbance maxima at 223 nm in methanol. The linearity was obtained in the concentration range of 2-16 μg/ ml and 3-24 μg/ml for telmisartan and metoprolol succinate, respectively. The concentrations of the drugs were determined by using absorbance correction method at both the wavelengths. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The suitability of this method for the quantitative determination of telmisartan and metoprolol succinate was proved by validation. The proposed method was found to be simple and sensitive for the quality control application of telmisartan and metoprolol succinate in pharmaceutical dosage form.
  
  
  RESULTS
  The result of analysis has been validated statistically and by recovery studies. Recoveries were found in the range of 98.08-100.55% of telmisartan and 98.41-101.87% of metoprolol succinate.
authors.affiliation: Shri Saravajanik Pharmacy College, Mehasana, Gujarat, India.
authors.forename: Komal
authors.initials: K
authors.lastname: Patel
authors.forename: Amit
authors.initials: A
authors.lastname: Patel
authors.forename: Jayant
authors.initials: J
authors.lastname: Dave
authors.forename: Chaganbhai
authors.initials: C
authors.lastname: Patel
keywords: Absorbance correction; metoprolol succunate; spectrophotometry; telmisartan