title: The controversy in the management of the N0 neck for squamous cell carcinoma of the maxillary sinus.
abstract: Squamous cell carcinoma (SCC) of the maxillary sinus is a relatively rare disease. As the reported incidence of regional metastasis varies widely, controversy exists as to whether or not the N0 classified neck should be treated electively. In this review, the data from published series are analyzed to decide on a recommendation of elective treatment of the neck in maxillary SCC. The published series consist of heterogeneous populations of different subsites of the paranasal sinuses, different histological types, different staging and treatment modalities used and different ways of reporting the results. These factors do not allow for recommendations based on high levels of evidence. Given this fact, the relatively high incidence rate of regional metastasis at presentation or in follow-up in the untreated N0 neck, and the relatively low toxicity of elective neck irradiation, such irradiation in SCC of the maxillary sinus should be considered.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands, r.takes@kno.umcn.nl.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Takes
authors.forename: Alfio
authors.initials: A
authors.lastname: Ferlito
authors.forename: Carl E
authors.initials: CE
authors.lastname: Silver
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rinaldo
authors.forename: Jesus E
authors.initials: JE
authors.lastname: Medina
authors.forename: K Thomas
authors.initials: KT
authors.lastname: Robbins
authors.forename: Juan P
authors.initials: JP
authors.lastname: Rodrigo
authors.forename: Marc
authors.initials: M
authors.lastname: Hamoir
authors.forename: Carlos
authors.initials: C
authors.lastname: Suárez
authors.forename: Peter
authors.initials: P
authors.lastname: Zbären
authors.forename: Vanni
authors.initials: V
authors.lastname: Mondin
authors.forename: Ashok R
authors.initials: AR
authors.lastname: Shaha
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
authors.forename: Primož
authors.initials: P
authors.lastname: Strojan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008444:Maxillary Sinus Neoplasms / Q000473:pathology / Q000628:therapy*; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant