title: Mind the IQGAP.
abstract: The scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway. Recent data show that cancer cells in which the RAF/MEK/ERK pathway is activated are particularly sensitive to the disruption of IQGAP1 function. IQGAP drugs may be particularly effective in tumors that develop resistance to existing pathway drugs.
authors.affiliation: Molecular Oncology Group, The Paterson Institute for Cancer Research, Manchester M20 4, UK.
authors.forename: Berta
authors.initials: B
authors.lastname: Sanchez-Laorden
authors.forename: Amaya
authors.initials: A
authors.lastname: Viros
authors.forename: Richard
authors.initials: R
authors.lastname: Marais
mesh_terms: D000818:Animals; D006801:Humans; D020935:MAP Kinase Signaling System; D009369:Neoplasms / Q000378:metabolism*; D020703:ras GTPase-Activating Proteins / Q000378:metabolism*; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D020703:ras GTPase-Activating Proteins; D018631:ras Proteins