title: N-terminal tagging of two-pore channels interferes with NAADP action.
abstract: NAADP (nicotinic acid-adenine dinucleotide phosphate) is the most potent Ca2+-releasing second messenger known to date. Since its discovery in 1995 identifying the NAADP receptor protein/Ca2+ channel has been a major persuit of the Ca2+ signalling community. In their paper 'The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP' published in this issue of the Biochemical Journal Patel and colleagues describe that the N-terminus of one of the NAADP receptor protein/Ca2+ channel candidates, TPC1 (two-pore channel 1), is crucial for protein targeting and for sensitivity to NAADP.
authors.affiliation: The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. guse@uke.de
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Guse
mesh_terms: D015220:Calcium Channels / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D009249:NADP / Q000031:analogs & derivatives* / Q000502:physiology; D000097903:Two-Pore Channels
chemical_list: D015220:Calcium Channels; D009249:NADP; C407357:TPCN1 protein, human; D000097903:Two-Pore Channels; C024376:NAADP