title: Hypertension promotes islet morphological changes with vascular injury on pre-diabetic status in SHRsp rats.
abstract: Abstract Hypertensive patients have a higher incidence of new-onset diabetic mellitus than normotensive subjects, and we hypothesized that hypertension induces morphological changes in islets via vascular injury. To test our hypothesis, we administrated hydralazine or irbesartan to spontaneously hypertensive stroke-prone (SHRsp) rats. A greater islet fibrosis was observed in SHRsp rats compared with controls, and irbesartan significantly ameliorated the fibrosis. High fat diet induced glucose intorelance in SHRsp rats and irbesartan but not hydralazine improved glucose torelance. We demonstrate islet morphological changes in hypertensive rats, and our data suggest that angiotensin receptor blockers have the potential to prevent islet injury.
authors.affiliation: Department of Nephrology and Hypertension, Kawasaki Medical School , Okayama 701-0192 , Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Satoh
authors.forename: Hajime
authors.initials: H
authors.lastname: Nagasu
authors.forename: Yoshisuke
authors.initials: Y
authors.lastname: Haruna
authors.forename: Chieko
authors.initials: C
authors.lastname: Ihoriya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kadoya
authors.forename: Tamaki
authors.initials: T
authors.lastname: Sasaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Kashihara
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D001794:Blood Pressure / Q000502:physiology; D004195:Disease Models, Animal; D006830:Hydralazine / Q000494:pharmacology; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D000077405:Irbesartan; D007515:Islets of Langerhans / Q000187:drug effects / Q000473:pathology*; D008297:Male; D011236:Prediabetic State / Q000150:complications*; D011918:Rats, Inbred SHR; D013777:Tetrazoles / Q000494:pharmacology; D057772:Vascular System Injuries / Q000139:chemically induced
chemical_list: D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D013777:Tetrazoles; D006830:Hydralazine; D000077405:Irbesartan