title: Inhibitors of apoptotic proteins: new targets for anticancer therapy.
abstract: Inhibitors of apoptotic proteins (IAPs) can play an important role in inhibiting apoptosis by exerting their negative action on caspases (apoptotic proteins). There are eight proteins in this family: NAIP/BIRC1/NLRB, cellular IAP1 (cIAP1)/human IAP2/BIRC2, cellular IAP2 (cIAP2)/human IAP1/BIRC3, X-linked IAP (XIAP)/BIRC4, survivin/BIRC5, baculoviral IAP repeat (BIR)-containing ubiquitin-conjugating enzyme/apollon/BIRC6, livin/melanoma-IAP (ML-IAP)/BIRC7/KIAP, and testis-specific IAP (Ts-IAP)/hILP-2/BIRC8. Deregulation of these inhibitors of apoptotic proteins (IAPs) may push cell toward cancer and neurodegenerative disorders. Inhibitors of apoptotic proteins (IAPs) may provide new target for anticancer therapy. Drugs may be developed that are inhibiting these IAPs to induce apoptosis in cancerous cells.
authors.affiliation: College of Pharmacy, GC University, Faisalabad, Pakistan; University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saleem
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Qadir
authors.forename: Nadia
authors.initials: N
authors.lastname: Perveen
authors.forename: Bashir
authors.initials: B
authors.lastname: Ahmad
authors.forename: Uzma
authors.initials: U
authors.lastname: Saleem
authors.forename: Tehseen
authors.initials: T
authors.lastname: Irshad
authors.forename: Bashir
authors.initials: B
authors.lastname: Ahmad
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D051017:Apoptosis Regulatory Proteins; D053477:Apoptotic Protease-Activating Factor 1 / Q000378:metabolism; D053148:Caspase 3 / Q000378:metabolism; D053453:Caspase 9 / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: C506592:APAF1 protein, human; D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; D053477:Apoptotic Protease-Activating Factor 1; C412403:DIABLO protein, human; D051034:Inhibitor of Apoptosis Proteins; D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein; D053148:Caspase 3; D053453:Caspase 9
keywords: BIR-containing (BIRC) proteins; baculovirus IAP repeat (BIR); inhibitors of apoptotic proteins (IAPs)