title: Cutaneous histoplasmosis disclosing an HIV-infection.
abstract: Histoplasmosis is a systemic mycosis endemic in extensive areas of the Americas. The authors report on an urban adult male patient with uncommon oral-cutaneous lesions proven to be histoplasmosis. Additional investigation revealed unnoticed HIV infection with CD4+ cell count of 7/mm3. The treatment was performed with amphotericin B, a 2065 mg total dose followed by itraconazole 200mg/daily plus antiretroviral therapy with apparent cure. Histoplasmosis is an AIDS-defining opportunistic disease process; therefore, its clinical diagnosis must drive full laboratory investigation looking for unnoted HIV-infection.
authors.affiliation: Department of Dermatology and Radiotherapy, Botucatu Medical School, São Paulo State University, Sao Paulo, SP, Brazil. smarques@fmb.unesp.br
authors.forename: Silvio Alencar
authors.initials: SA
authors.lastname: Marques
authors.forename: Maria Regina Cavariani
authors.initials: MR
authors.lastname: Silvares
authors.forename: Rosangela Maria Pires de
authors.initials: RM
authors.lastname: Camargo
authors.forename: Mariangela Esther Alencar
authors.initials: ME
authors.lastname: Marques
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000473:pathology*; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D003881:Dermatomycoses / Q000188:drug therapy / Q000473:pathology*; D006660:Histoplasmosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B