title: Tick-specific borrelial antigens appear to be upregulated in American but not European patients with Lyme arthritis, a late manifestation of Lyme borreliosis.
abstract: Borrelia burgdorferi (Bb) sensu lato, the etiologic agent of Lyme borreliosis, adapts to distinct environments in the mammalian host and the tick vector by differential gene expression. As a result, infected mice are not exposed to and rarely make antibodies to the set of antigens that are preferentially expressed in the tick, including outer surface protein A (OspA), Borrelia iron and copper-binding protein A (BicA), and OspD. Surprisingly, however, antibodies to OspA and BicA have been noted in American patients with Lyme arthritis. Here, we examined serum samples from 210 American patients and 66 European patients with a range of early or late manifestations of Lyme borreliosis and found that only American patients with Lyme arthritis commonly had antibody responses to OspA, BicA, and OspD. This suggests that infection with American but not European Borrelia strains often leads to concerted upregulation or derepression of tick-specific spirochetal antigens in these patients.
authors.affiliation: Department of Veterinary Biosciences, The Ohio State University, Columbus, USA. xin.li@cvm.osu.edu
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Klemen
authors.initials: K
authors.lastname: Strle
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: David I
authors.initials: DI
authors.lastname: Acosta
authors.forename: Gail A
authors.initials: GA
authors.lastname: McHugh
authors.forename: Nikhil
authors.initials: N
authors.lastname: Sikand
authors.forename: Franc
authors.initials: F
authors.lastname: Strle
authors.forename: Allen C
authors.initials: AC
authors.lastname: Steere
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001428:Bacterial Vaccines / Q000235:genetics; D015748:Borrelia burgdorferi Group / Q000145:classification; D005060:Europe; D005838:Genotype; D006801:Humans; D008074:Lipoproteins / Q000235:genetics; D008193:Lyme Disease / Q000097:blood* / Q000276:immunology; D013987:Ticks / Q000382:microbiology*; D014481:United States; D015854:Up-Regulation
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D008074:Lipoproteins; C072045:OspA protein; C077524:outer surface protein D, Borrelia burgdorferi
keywords: BicA; Borrelia burgdorferi; Lyme borreliosis; OspA; OspD; antibody response; tick