title: Lipid peroxidation and depressed mood in community-dwelling older men and women.
abstract: It has been hypothesized that cellular damage caused by oxidative stress is associated with late-life depression but epidemiological evidence is limited. In the present study we evaluated the association between urinary 8-iso-prostaglandin F2α (8-iso-PGF2α), a biomarker of lipid peroxidation, and depressed mood in a large sample of community-dwelling older adults. Participants were selected from the Health, Aging and Body Composition study, a community-based longitudinal study of older persons (aged 70-79 years). The present analyses was based on a subsample of 1027 men and 948 women free of mobility disability. Urinary concentration of 8-iso-PGF2α was measured by radioimmunoassay methods and adjusted for urinary creatinine. Depressed mood was defined as a score greater than 5 on the 15-item Geriatric Depression Scale and/or use of antidepressant medications. Depressed mood was present in 3.0% of men and 5.5% of women. Depressed men presented higher urinary concentrations of 8-iso-PGF2α than non-depressed men even after adjustment for multiple sociodemographic, lifestyle and health factors (p = 0.03, Cohen's d = 0.30). This association was not present in women (depressed status-by-sex interaction p = 0.04). Our study showed that oxidative damage may be linked to depression in older men from a large sample of the general population. Further studies are needed to explore whether the modulation of oxidative stress may break down the link between late-life depression and its deleterious health consequences.
authors.affiliation: Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands. y.milaneschi@ggzingeest.nl
authors.forename: Yuri
authors.initials: Y
authors.lastname: Milaneschi
authors.forename: Matteo
authors.initials: M
authors.lastname: Cesari
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Simonsick
authors.forename: Nicole
authors.initials: N
authors.lastname: Vogelzangs
authors.forename: Alka M
authors.initials: AM
authors.lastname: Kanaya
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
authors.forename: Paola
authors.initials: P
authors.lastname: Patrignani
authors.forename: Andrea
authors.initials: A
authors.lastname: Metti
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Brenda W J H
authors.initials: BW
authors.lastname: Penninx
mesh_terms: D000368:Aged; D003863:Depression / Q000503:physiopathology* / Q000652:urine*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D012737:Sex Factors
chemical_list: C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost