title: Periprocedural management of oral anticoagulation in patients with atrial fibrillation: approach in the era of new oral anticoagulants.
abstract: A growing number of patients with atrial fibrillation are treated with oral anticoagulation (OAC), and a large proportion of them will require surgical or other invasive procedures. These procedures typically involve interruption of OAC with or without the use of heparin bridging; however; there has been a dramatic change in this practice during the past 3 years. The introduction of short-acting, new oral anticoagulants and the growing popularity of some low-risk procedures with continued OAC have transformed our practice. Physicians and surgeons who treat patients with atrial fibrillation must be aware of these changes and understand how to deal with the new challenges they may encounter.
authors.affiliation: Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. Jeff.Healey@Phri.ca
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Healey
authors.forename: Michela
authors.initials: M
authors.lastname: Brambatti
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000145:classification; D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D001777:Blood Coagulation / Q000187:drug effects*; D004333:Drug Administration Routes; D016903:Drug Monitoring / Q000379:methods; D057915:Drug Substitution / Q000379:methods*; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D019990:Perioperative Care / Q000379:methods*; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D013923:Thromboembolism / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin