title: Epithelial to mesenchymal transition-the roles of cell morphology, labile adhesion and junctional coupling.
abstract: Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell-matrix adhesion in addition to modulating cell-cell adhesion.
authors.affiliation: School of Electronic, Electrical and Systems Engineering, Loughborough University, Loughborough, UK. T.Abdulla@lboro.ac.uk
authors.forename: Tariq
authors.initials: T
authors.lastname: Abdulla
authors.forename: Luis
authors.initials: L
authors.lastname: Luna-Zurita
authors.forename: José Luis
authors.initials: JL
authors.lastname: de la Pompa
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Schleich
authors.forename: Ron
authors.initials: R
authors.lastname: Summers
mesh_terms: D000465:Algorithms; D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion; D002450:Cell Communication; D002465:Cell Movement; D003198:Computer Simulation; D004699:Endocardium / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional; D061986:MCF-7 Cells; D051379:Mice; D008954:Models, Biological; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015820:Cadherins; D051880:Receptors, Notch
keywords: Cadherin; Development; Modelling; Motility; Notch; Plasticity