title: A comparison of the genetic and clinical profile of men that respond and do not respond to the immediate antihypertensive effects of aerobic exercise.
abstract: We compared the genetic and clinical profile of men who lower and do not lower blood pressure (BP) after acute aerobic exercise. Volunteers were 45 men (Mean ± SEM, 43.5 ± 1.5 yr) with high BP (145.7 ± 1.5/85.7 ± 1.1 mmHg). They completed three experiments: nonexercise control and two cycle exercise sessions at 40% and 60% peak oxygen consumption, and were then instrumented to an ambulatory BP monitor. Logistic regression determined the genetic and clinical profile of men who lowered BP after exercise (responders [ExR n = 36]); and those who did not (nonresponders [ExNR n = 9]). ExR had higher C-reactive protein (CRP), high-density lipoprotein (HDL), the metabolic syndrome, family history of hypertension, more renin-angiotensin system (RAS) common alleles, and α-adducin Trp(460) and endothelial nitric oxide synthase (ENOS) C(786) risk alleles. ExNR had lower CRP and HDL, did not have the metabolic syndrome and a family history of hypertension, had more RAS risk alleles, and had the α-adducin Gly460Gly and ENOS T786T genotypes. This model had a sensitivity of 97.1%, specificity of 75.0%, and accounted for 46.3%-74.4% of the BP response. These results suggest genetic and clinical information may eventually be used to characterize people who do and do not respond to exercise as antihypertensive therapy.
authors.affiliation: Department of Kinesiology, University of Connecticut, Storrs, CT, USA.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Pescatello
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Blanchard
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Tsongalis
authors.forename: Ann A
authors.initials: AA
authors.lastname: O'Connell
authors.forename: Heather
authors.initials: H
authors.lastname: Gordish-Dressman
authors.forename: Carl M
authors.initials: CM
authors.lastname: Maresh
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thompson
keywords: blood pressure; genetics; hypertension; metabolic syndrome; physical activity