title: Genome-wide association study of lung cancer in Korean non-smoking women.
abstract: Lung cancer in never-smokers ranks as the seventh most common cause of cancer death worldwide, and the incidence of lung cancer in non-smoking Korean women appears to be steadily increasing. To identify the effect of genetic polymorphisms on lung cancer risk in non-smoking Korean women, we conducted a genome-wide association study of Korean female non-smokers with lung cancer. We analyzed 440,794 genotype data of 285 cases and 1,455 controls, and nineteen SNPs were associated with lung cancer development (P < 0.001). For external validation, nineteen SNPs were replicated in another sample set composed of 293 cases and 495 controls, and only rs10187911 on 2p16.3 was significantly associated with lung cancer development (dominant model, OR of TG or GG, 1.58, P = 0.025). We confirmed this SNP again in another replication set composed of 546 cases and 744 controls (recessive model, OR of GG, 1.32, P = 0.027). OR and P value in combined set were 1.37 and < 0.001 in additive model, 1.51 and < 0.001 in dominant model, and 1.54 and < 0.001 in recessive model. The effect of this SNP was found to be consistent only in adenocarcinoma patients (1.36 and < 0.001 in additive model, 1.49 and < 0.001 in dominant model, and 1.54 and < 0.001 in recessive model). Furthermore, after imputation with HapMap data, we found regional significance near rs10187911, and five SNPs showed P value less than that of rs10187911 (rs12478012, rs4377361, rs13005521, rs12475464, and rs7564130). Therefore, we concluded that a region on chromosome 2 is significantly associated with lung cancer risk in Korean non-smoking women.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Park
authors.forename: Seon-Hee
authors.initials: SH
authors.lastname: Yim
authors.forename: Jin Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Jae Sook
authors.initials: JS
authors.lastname: Sung
authors.forename: Ju-Yeon
authors.initials: JY
authors.lastname: Park
authors.forename: Yi Young
authors.initials: YY
authors.lastname: Choi
authors.forename: Hyo-Sung
authors.initials: HS
authors.lastname: Jeon
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
authors.forename: Hyoung Kyu
authors.initials: HK
authors.lastname: Yoon
authors.forename: Yeul Hong
authors.initials: YH
authors.lastname: Kim
authors.forename: Byung Su
authors.initials: BS
authors.lastname: Yoo
authors.forename: Young Tae
authors.initials: YT
authors.lastname: Kim
authors.forename: Hae-Jin
authors.initials: HJ
authors.lastname: Hu
authors.forename: Yeun-Jun
authors.initials: YJ
authors.lastname: Chung
authors.forename: Ho
authors.initials: H
authors.lastname: Kim
authors.forename: Sook Whan
authors.initials: SW
authors.lastname: Sung
authors.forename: Yun-Chul
authors.initials: YC
authors.lastname: Hong
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008957:Models, Genetic; D009419:Nerve Tissue Proteins / Q000235:genetics*; D019006:Neural Cell Adhesion Molecules; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea
chemical_list: D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal; C539628:NRXN1 protein, human; D009419:Nerve Tissue Proteins; D019006:Neural Cell Adhesion Molecules
keywords: Genome-Wide Association Study; Lung Neoplasms; Non-Smoking Women