title: The detection of antibodies to the Angiotensin II-type 1 receptor in transplantation.
abstract: The detection of auto-antibodies detection is a major aspect of patient's immunomonitoring. Antibodies directed against the heart and kidney Angiotensin II type 1 receptor (AT1R) play a major role in antibody mediated rejection after heart and kidney transplantation and in obliterative vasculopathy of autoimmune diseases. Here, a sandwich enzyme-linked immunosorbent assay (ELISA) is the reliable tool for the detection of auto-antibodies targeting AT1R.
authors.affiliation: Clinic for Nephrology and Intensive Care Medicine, Charité-Campus Virchow-Klinikum, Berlin, Germany.
authors.forename: Duska
authors.initials: D
authors.lastname: Dragun
mesh_terms: D000804:Angiotensin II / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D008967:Molecular Biology / Q000379:methods; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II