title: [Influence of hypoxen on acetylsalicylic acid efficiency in acute inflammation].
abstract: Rats were treated by subplantar injections of 0.1 ml 1% carrageenan solution. In 3 hours, this led to the development of acute inflammatory reaction (swelling of legs, neutrophilic leukocytosis, increased erythrocyte sedimentation rate, activation of free-radical oxidation). Acetylsalicylic acid in a dose of 100 mg/kg reduced development of the inflammatory response. Hypoxen in a dose of 50 mg/kg potentiated the effect of acetylsalicylic acid. The injection of both hypoxen and acetylsalicylic acid before the injection of carrageenan produced a strong anti-inflammatory effect, which was manifested by a reliable decrease in all monitored signs of inflammation.
authors.forename: V E
authors.initials: VE
authors.lastname: Novikov
authors.forename: S A
authors.initials: SA
authors.lastname: Iliuchin
mesh_terms: D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000819:agonists* / Q000494:pharmacology*; D001241:Aspirin / Q000819:agonists* / Q000494:pharmacology*; D002351:Carrageenan / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D054313:Drug Agonism; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D010647:Phenyl Ethers / Q000819:agonists* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D010647:Phenyl Ethers; C085806:olifen; D002351:Carrageenan; D001241:Aspirin