title: A central role for inducible heat-shock protein 70 in autoimmune vitiligo.
abstract: Inducible heat-shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. In the presence of stress proteins, dendritic cells (DCs) will sense this alarm signal and respond by recruiting immune cells of different plumage to fit the occasion. In times of stress, melanocytes will secrete antigen-bound HSP70i to act as an alarm signal in activating DCs that comes equipped with an address of origin to drive the autoimmune response in vitiligo. Here we pose that if the autoimmune response is funnelled through HSP70i, then blocking the stress protein from activating DCs can lend new treatment opportunities for vitiligo.
authors.affiliation: Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Mosenson
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Eby
authors.forename: Claudia
authors.initials: C
authors.lastname: Hernandez
authors.forename: I Caroline
authors.initials: IC
authors.lastname: Le Poole
mesh_terms: D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D019496:Cancer Vaccines / Q000627:therapeutic use; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008544:Melanocytes / Q000276:immunology; D008545:Melanoma / Q000276:immunology; D011506:Proteins / Q000378:metabolism; D014820:Vitiligo / Q000209:etiology / Q000276:immunology* / Q000628:therapy
chemical_list: D019496:Cancer Vaccines; D018840:HSP70 Heat-Shock Proteins; D011506:Proteins; C018589:lysosomal proteins
keywords: T cell; autoimmune; dendritic cell; depigmentation; heat-shock protein; mouse model; stress