title: Three-component reaction of small-ring cyclic amines with arynes and acetonitrile.
abstract: A novel stereospecific three-component reaction of aziridines and azetidines with arynes and acetonitrile has been developed. The reaction affords N-aryl γ-aminobutyronitriles and δ-aminovaleronitriles that can be used as precursors and congeners of a number of bioactive compounds, such as pregabalin and lergotrile.
authors.affiliation: Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors.forename: David
authors.initials: D
authors.lastname: Stephens
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Mathew
authors.initials: M
authors.lastname: Cormier
authors.forename: Gabriel
authors.initials: G
authors.lastname: Chavez
authors.forename: Hadi
authors.initials: H
authors.lastname: Arman
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Larionov