title: Systems analysis of arrestin pathway functions.
abstract: To fully appreciate the diversity and specificity of complex cellular signaling events, such as arrestin-mediated signaling from G protein-coupled receptor activation, a complex systems-level investigation currently appears to be the best option. A rational combination of transcriptomics, proteomics, and interactomics, all coherently integrated with applied next-generation bioinformatics, is vital for the future understanding of the development, translation, and expression of GPCR-mediated arrestin signaling events in physiological contexts. Through a more nuanced, systems-level appreciation of arrestin-mediated signaling, the creation of arrestin-specific molecular response "signatures" should be made simple and ultimately amenable to drug discovery processes. Arrestin-based signaling paradigms possess important aspects, such as its specific temporal kinetics and ability to strongly affect transcriptional activity, that make it an ideal test bed for next-generation of drug discovery bioinformatic approaches such as multi-parallel dose-response analysis, data texturization, and latent semantic indexing-based natural language data processing and feature extraction.
authors.affiliation: Receptor Pharmacology Unit, National Institute on Aging, Baltimore, Maryland, USA.
authors.forename: Stuart
authors.initials: S
authors.lastname: Maudsley
authors.forename: Sana
authors.initials: S
authors.lastname: Siddiqui
authors.forename: Bronwen
authors.initials: B
authors.lastname: Martin
mesh_terms: D000818:Animals; D019393:Arrestin / Q000378:metabolism*; D019295:Computational Biology; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction; D049490:Systems Biology
chemical_list: D019393:Arrestin; D043562:Receptors, G-Protein-Coupled