title: Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer.
abstract: OBJECTIVE
  The aim of this study was to establish the guidelines for detecting early recurrences of advanced epithelial ovarian cancer by use of the CA-125 level.
  
  
  METHODS
  Eighty-five of the patients who met the inclusion criteria were enrolled in this study. The authors examined 25 incremental changes of CA125 from one to 25 IU/ml, and compared the CA-125 value with other prognostic factors. Increases in the CA-125 level from the nadir level were expressed as CA-125- increments.
  
  
  RESULTS
  Among the 25 increments, a CA-125-8 (eight IU/ml) was selected as the predictor that was the most efficient and time-effective. CA-125-8 had a sensitivity of 91.5%, a specificity of 84.6%, a positive predictive value of 93.1%, a negative predictive value of 81.5%, an efficiency of 89.4%. and a median lead-time of 68.5 days (p <0.0001).
  
  
  CONCLUSIONS
  The authors suggest the incremented CA-125-8 as a predictor of recurrent advanced ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea. bitsugar@catholic.ac.kr
authors.forename: M J
authors.initials: MJ
authors.lastname: Song
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: M R
authors.initials: MR
authors.lastname: Choi
authors.forename: H J
authors.initials: HJ
authors.lastname: Son
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Yoon
authors.forename: Y G
authors.initials: YG
authors.lastname: Park
authors.forename: S Y
authors.initials: SY
authors.lastname: Hur
authors.forename: K S
authors.initials: KS
authors.lastname: Ryu
authors.forename: J M
authors.initials: JM
authors.lastname: Lee
mesh_terms: D018394:CA-125 Antigen / Q000097:blood*; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D016015:Logistic Models; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis*; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood / Q000175:diagnosis*; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis*
chemical_list: D018394:CA-125 Antigen