title: Gastrointestinal histoplasmosis in a hepatitis C-infected individual.
abstract: Gastrointestinal histoplasmosis is a rare manifestation of this fungal infection, typically identified in immunocompromised patients, such as those with HIV/AIDS. Here, we report a case of disseminated histoplasmosis with gastrointestinal involvement in a Hepatitis C-infected patient. The fungal agent was confirmed to be Histoplasma capsulatum by a DNA probe assay performed on a bone marrow sample. We propose that this fungal disease should be kept on the differential of patients infected with the Hepatitis C virus, as it has been reported to have numerous damaging effects on the adaptive immune system.
authors.affiliation: Department of Pathology, Ben Taub General Hospital, Houston, TX, USA. pmrodrig@bcm.edu
authors.forename: Paul M
authors.initials: PM
authors.lastname: Rodriguez-Waitkus
authors.forename: Vafa
authors.initials: V
authors.lastname: Bayat
authors.forename: Elias
authors.initials: E
authors.lastname: George
authors.forename: Norbert
authors.initials: N
authors.lastname: Sule
mesh_terms: D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006651:Histocytochemistry / Q000379:methods; D006658:Histoplasma / Q000235:genetics / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008828:Microbiological Techniques; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques