title: The kinetics of vitamin D₃ in the osteoblastic cell.
abstract: Experimental evidence is presented on the translocation of vitamin D metabolite, 1,25-(OH)₂D₃, from the membrane to the nucleus in osteoblast progenitor cells. A mathematical model permitting traversal of the cytoplasm at either a fixed velocity or by diffusion is formulated in order to determine whether transport along the cytoskeletal tracks is more consistent with the observed spatial-temporal distribution than diffusion, and it is so found. The model includes reactions in the nucleus involving D₃ to form other compounds, such as protegerin, and thus also makes predictions of the concentrations of these compounds in various regions of the cell.
authors.affiliation: Mathematics Department, United States Naval Academy, Annapolis, MD, USA. jlb@usna.edu
authors.forename: James L
authors.initials: JL
authors.lastname: Buchanan
authors.forename: Robert
authors.initials: R
authors.lastname: Gilbert
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Ou
authors.forename: Anja
authors.initials: A
authors.lastname: Nohe
authors.forename: Rachel
authors.initials: R
authors.lastname: Schaefer
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002451:Cell Compartmentation; D002460:Cell Line; D048430:Cell Shape; D002762:Cholecalciferol / Q000378:metabolism*; D019295:Computational Biology; D007700:Kinetics; D055641:Mathematical Concepts; D051379:Mice; D008954:Models, Biological; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D045663:Quantum Dots
chemical_list: D002762:Cholecalciferol