title: Iron in child obesity. Relationships with inflammation and metabolic risk factors.
abstract: Iron (Fe) sequestration is described in overweight and in its associated metabolic complications, i.e., metabolic syndrome (MetS) and non-alcoholic liver fatty disease (NAFLD); however, the interactions between Fe, obesity and inflammation make it difficult to recognize the specific role of each of them in the risk of obesity-induced metabolic diseases. Even the usual surrogate marker of Fe stores, ferritin, is influenced by inflammation; therefore, in obese subjects inflammation parameters must be measured together with those of Fe metabolism. This cross-sectional study in obese youth (502 patients; 57% girls): 11.4 ± 3.0 years old (x ± SD); BMI z score 5.5 ± 2.3), multivariate regression analysis showed associations between Fe storage assessed by serum ferritin with risk factors for MetS and NAFLD, assessed by transaminase levels, which were independent of overweight and the acute phase protein fibrinogen. Further studies incorporating the measurement of complementary parameters of Fe metabolism could improve the comprehension of mechanisms involved.
authors.affiliation: Pediatric Department, CHU de Caen, 14033 Caen cedex, France. dbougle@wanadoo.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Bouglé
authors.forename: Jacques
authors.initials: J
authors.lastname: Brouard
mesh_terms: D000293:Adolescent; D001794:Blood Pressure; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000097:blood / Q000150:complications; D005260:Female; D005293:Ferritins / Q000097:blood; D005340:Fibrinogen / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications; D007501:Iron / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease; D063766:Pediatric Obesity / Q000097:blood* / Q000150:complications; D012044:Regression Analysis; D012307:Risk Factors; D000637:Transaminases / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D005340:Fibrinogen; D005293:Ferritins; D007501:Iron; D000637:Transaminases