title: Lappaconitine: influence of halogen substituent on the antiarrhythmic activity.
abstract: The current paper presents research results related to antiarrhythmic activity of halogen-containing derivatives of lappaconitine. Lappaconitine derivatives with iodine, chlorine or bromine substituting the anthranilate moiety at C-5` position were shown in vivo and in vitro to exhibit a more (Br, I) or less (Cl) pronounced antiarrhythmic activity in the models of calcium chloride- and adrenaline-induced arrhythmias as compared with the reference compound lappaconitine. The intensity of antiarrhythmic action depending on halogen substituent was found to be expressed by the following order: Cl < I < Br.
authors.forename: A O
authors.initials: AO
authors.lastname: Bryzgalov
authors.forename: V E
authors.initials: VE
authors.lastname: Romanov
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.affiliation: Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Prosp. Akad. Lavrent`eva, 630090 Novosibirsk, Russian Federation. romanov@nioch.nsc.ru.
authors.forename: E E
authors.initials: EE
authors.lastname: Shults
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry* / Q000494:pharmacology*; D004195:Disease Models, Animal; D006219:Halogens / Q000737:chemistry*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D051381:Rats
chemical_list: D000889:Anti-Arrhythmia Agents; D006219:Halogens; D000157:Aconitine; C022150:lappaconitine