title: Characteristics of patients with advanced heart failure having eosinophilic infiltration of the myocardium in the recent era.
abstract: Eosinophilic infiltration of the myocardium is occasionally observed as an incidental histological finding in endomyocardial biopsy specimens before heart transplantation (HTx) as well as in explanted heart obtained at the time of HTx. However, the indications for HTx in these patients have not yet been fully established. We investigated the pre-HTx characteristics of the recipients with myocardial eosinophilic infiltration in the explanted heart and diagnosed as hypersensitivity myocarditis (HSM) (21 among 761 recipients, 2.8%). Dobutamine, a common cause of HSM, was administered to 12 patients (57%). Ten patients (47.6%) were on milrinone and 4 (19.0%) were on ventricular assist devices. Post-transplant survival of HSM patients was comparable to that of patients transplanted for active myocarditis or other cause of heart failure. In conclusion, myocardial eosinophilic infiltration is associated with multiple medications in patients with advanced heart failure; however, it does not affect the post-transplant prognosis.
authors.affiliation: Department of Pathology & Cell Biology, Columbia University Medical Center and The New York Presbyterian Hospital, New York 10032, USA.
authors.forename: Saeko
authors.initials: S
authors.lastname: Yoshizawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sugiyama Kato
authors.forename: Donna
authors.initials: D
authors.lastname: Mancini
authors.forename: Charles
authors.initials: C
authors.lastname: C Marboe
mesh_terms: D001706:Biopsy; D004280:Dobutamine / Q000008:administration & dosage / Q000009:adverse effects; D004804:Eosinophils / Q000473:pathology*; D006333:Heart Failure / Q000139:chemically induced / Q000473:pathology* / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D020105:Milrinone / Q000008:administration & dosage / Q000009:adverse effects; D009205:Myocarditis / Q000139:chemically induced / Q000473:pathology* / Q000601:surgery; D009206:Myocardium / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: D004280:Dobutamine; D020105:Milrinone