title: Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination.
abstract: Chinese painted quails immunized with a single dose (6 μg HA) of inactivated H5N1 (clade 1) influenza vaccine NIBRG-14 and challenged with 100 LD50 of the heterologous A/Swan/Nagybaracska/01/06(H5N1) (clade 2.2) strain were protected, whereas unvaccinated quails died after challenge. No viral antigens or RNA were detected in cloacal swabs from immunized animals. Sera obtained post-immunization gave low titres in serological assays against the vaccine and the challenge viruses. Our results demonstrate the protective efficacy of the NIBRG-14 strain against the challenge virus and the usefulness of these small birds in protection studies of influenza vaccines.
authors.affiliation: Division of Virology, National Center for Epidemiology, Budapest, 1097, Hungary.
authors.forename: Julia
authors.initials: J
authors.lastname: Sarkadi
authors.forename: Mate
authors.initials: M
authors.lastname: Jankovics
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Kis
authors.forename: Jozsef
authors.initials: J
authors.lastname: Skare
authors.forename: Kinga
authors.initials: K
authors.lastname: Fodor
authors.forename: Eva
authors.initials: E
authors.lastname: Gonczol
authors.forename: Ildiko
authors.initials: I
authors.lastname: Visontai
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Vajo
authors.forename: Istvan
authors.initials: I
authors.lastname: Jankovics
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002988:Cloaca / Q000821:virology; D003370:Coturnix / Q000276:immunology / Q000821:virology*; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D005585:Influenza in Birds / Q000276:immunology / Q000517:prevention & control*; D016019:Survival Analysis; D014611:Vaccination / Q000379:methods*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated