title: Simultaneous determination of cyflumetofen and its main metabolite residues in samples of plant and animal origin using multi-walled carbon nanotubes in dispersive solid-phase extraction and ultrahigh performance liquid chromatography-tandem mass spectrometry.
abstract: A rapid and effective method for the simultaneous determination of cyflumetofen and its main metabolite residues in samples of plant and animal origin (tomato, apple, eggplant, soybean, green tea, fish, and pork liver) was developed using ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Samples were extracted with acetonitrile and cleaned-up with multi-walled carbon nanotubes (MWCNTs). The determination of the presence of target compounds was achieved in less than 4.0min using an electrospray ionization source in the positive mode (ESI+) for cyflumetofen and 2-(trifluoromethyl) benzamide (B-3) and the negative mode (ESI-) for α,α,α-trifluoro-o-toluic acid (B-1). The entire method was validated by evaluating the repeatability, linearity, precision, trueness, and matrix effect. Average recoveries of the analytes were in the range of 79.3-117.6% with relative standard deviation values below 7.6%. Limits of quantification (LOQs) ranged from 0.7 to 9.8μgkg(-1), which were lower than the maximum residue limits (MRLs) for the cyflumetofen found in foods in Japan.
authors.affiliation: State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
authors.forename: Minmin
authors.initials: M
authors.lastname: Li
authors.forename: Xingang
authors.initials: X
authors.lastname: Liu
authors.forename: Fengshou
authors.initials: F
authors.lastname: Dong
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Kong
authors.forename: Yuanbo
authors.initials: Y
authors.lastname: Li
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D000327:Adsorption; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005399:Fishes; D005504:Food Analysis / Q000379:methods*; D005638:Fruit / Q000737:chemistry; D057230:Limit of Detection; D008460:Meat / Q000032:analysis; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011422:Propionates / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D015203:Reproducibility of Results; D052616:Solid Phase Extraction / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization; D013552:Swine; D053719:Tandem Mass Spectrometry / Q000379:methods; D013662:Tea / Q000737:chemistry; D014675:Vegetables / Q000737:chemistry
chemical_list: D000097:Acetonitriles; D037742:Nanotubes, Carbon; D011422:Propionates; D013662:Tea; C572153:cyflumetofen; C032159:acetonitrile
keywords: Animal origin; Cyflumetofen; Metabolites; Plant origin; UPLC–MS/MS; WMCNTs