title: Dual effects of resveratrol on arterial damage induced by insulin resistance in aged mice.
abstract: Aging leads to increased insulin resistance and arterial dysfunction, with oxidative stress playing an important role. This study explored the metabolic and arterial effects of a chronic treatment with resveratrol, an antioxidant polyphenol compound that has been shown to restore insulin sensitivity and decrease oxidative stress, in old mice with or without a high-protein diet renutrition care. High-protein diet tended to increase insulin resistance and atheromatous risk. Resveratrol improved insulin sensitivity in old mice fed standard diet by decreasing homeostasis model of assessment-insulin resistance and resistin levels. However, resveratrol did not improve insulin resistance status in old mice receiving the high-protein diet. In contrast, resveratrol exhibited deleterious effects by increasing inflammation state and superoxide production and diminishing aortic distensibility. In conclusion, we demonstrate that resveratrol has beneficial or deleterious effects on insulin sensitivity and arterial function, depending on nutritional status in our models.
authors.affiliation: PharmD, Viva Team-EA 4466, Faculty of Pharmacy, Paris Descartes University, Sorbonne Paris Cité 75006, Paris Cedex, France. stephanie.baron@egp.aphp.fr.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Baron
authors.forename: Tatiana
authors.initials: T
authors.lastname: Bedarida
authors.forename: Charles-Henry
authors.initials: CH
authors.lastname: Cottart
authors.forename: Francoise
authors.initials: F
authors.lastname: Vibert
authors.forename: Emilie
authors.initials: E
authors.lastname: Vessieres
authors.forename: Audrey
authors.initials: A
authors.lastname: Ayer
authors.forename: Daniel
authors.initials: D
authors.lastname: Henrion
authors.forename: Baptiste
authors.initials: B
authors.lastname: Hommeril
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Paul
authors.forename: Gilles
authors.initials: G
authors.lastname: Renault
authors.forename: Bruno
authors.initials: B
authors.lastname: Saubamea
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Beaudeux
authors.forename: Vincent
authors.initials: V
authors.lastname: Procaccio
authors.forename: Valerie
authors.initials: V
authors.lastname: Nivet-Antoine
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001011:Aorta / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis; D018946:Chemokine CCL5 / Q000097:blood; D054360:Chemokine CXCL1 / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage; D004195:Disease Models, Animal; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009752:Nutritional Status; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000627:therapeutic use*; D052243:Resistin / Q000032:analysis; D000077185:Resveratrol; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*; D012709:Serum Albumin / Q000032:analysis; D013267:Stilbenes / Q000627:therapeutic use*; D013481:Superoxides / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D018924:Vascular Capacitance / Q000187:drug effects; D014652:Vascular Diseases / Q000188:drug therapy*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; C503460:Ccl5 protein, mouse; D018946:Chemokine CCL5; D054360:Chemokine CXCL1; C475895:Cxcl1 protein, mouse; D004044:Dietary Proteins; D020738:Leptin; D010636:Phenols; D052243:Resistin; C499623:Retn protein, mouse; D012709:Serum Albumin; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; D013481:Superoxides; D012264:Ribonucleotide Reductases; D000077185:Resveratrol
keywords: Aging; Insulin resistance; Renutrition.; Resveratrol; Vascular disease