title: Magnesium intake and risk of amyotrophic lateral sclerosis: results from five large cohort studies.
abstract: A low magnesium intake has been suggested to be associated with amyotrophic lateral sclerosis (ALS) in pathological and case-control studies, but prospective studies in humans are lacking. The relation between dietary intake of magnesium and ALS risk was explored in five large prospective cohort studies (the Nurses' Health Study, the Health Professionals Follow-up Study, the Cancer Prevention Study II Nutrition Cohort, the Multiethnic Cohort Study, and the National Institutes of Health - AARP Diet and Health Study), comprising over 1,050,000 males and females contributing 1093 cases of ALS during a mean of 15 years of follow-up. Cox proportional hazards models were used within each cohort, and cohort-specific estimates were subsequently pooled using a random-effects model. Results demonstrated that dietary magnesium intake was not associated with ALS risk, relative risk 1.07, 95% confidence interval 0.88 - 1.31 comparing the highest quintile of intake with the lowest. This finding does not support a protective effect of magnesium intake on ALS risk. Further analyses should explore magnesium intake in combination with heavy metal exposure and genetic variants affecting magnesium absorption.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA. efondell@hsph.harvard.edu
authors.forename: Elinor
authors.initials: E
authors.lastname: Fondell
authors.forename: Eilis J
authors.initials: EJ
authors.lastname: O'Reilly
authors.forename: Kathryn C
authors.initials: KC
authors.lastname: Fitzgerald
authors.forename: Guido J
authors.initials: GJ
authors.lastname: Falcone
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: McCullough
authors.forename: Yikyung
authors.initials: Y
authors.lastname: Park
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Alberto
authors.initials: A
authors.lastname: Ascherio
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology*; D015331:Cohort Studies; D004032:Diet / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008274:Magnesium; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D008274:Magnesium