title: Differential regulation of brain-derived neurotrophic factor in term and preterm preeclampsia.
abstract: Our earlier studies in preeclampsia (PE) suggest a causal relationship between altered angiogenic factors and birth outcomes. Recent studies suggest that brain-derived neurotrophic factor (BDNF) can stimulate angiogenesis. The present study examines the levels of maternal and cord BDNF in women with PE (n = 106; full term [n = 60] and preterm [n = 46]) and normotensive women (n = 95; control) delivering at term. Maternal BDNF levels were lower (P < .05) in women with PE when compared to normotensive women. Cord BDNF levels were higher (P < .01) in women with PE delivering at term, while it was lower (P < .01) in women delivering preterm. Maternal BDNF levels were negatively associated with systolic and diastolic blood pressure (P < .01 for both). Our data for the first time suggest a possible role for BDNF in the pathophysiology of PE. Differential regulation of cord BDNF levels in preterm PE suggests a need to follow-up children to assess the neurodevelopmental effects in later life.
authors.affiliation: 1Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune, Maharashtra, India.
authors.forename: Vandita A
authors.initials: VA
authors.lastname: D'Souza
authors.forename: Anitha S
authors.initials: AS
authors.lastname: Kilari
authors.forename: Asmita A
authors.initials: AA
authors.lastname: Joshi
authors.forename: Savita S
authors.initials: SS
authors.lastname: Mehendale
authors.forename: Hemlata M
authors.initials: HM
authors.lastname: Pisal
authors.forename: Sadhana R
authors.initials: SR
authors.lastname: Joshi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D047929:Term Birth / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: blood pressure; brain-derived neurotrophic factor; hypertension; preeclampsia