title: Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature.
abstract: Burkitt's lymphoma (BL) is an aggressive B-cell malignancy with very high proliferation rate, more common in males than females. Here, we describe a case of Burkitt's lymphoma in a 24-week pregnant woman with cervical and abdominal involvement. The common genetic event of virtually all BL is a reciprocal chromosomal translocation involving the proto-oncogene MYC and one of the Ig gene heavy or light chain loci. Supportive treatment was administered until early delivery, after which the patient was treated according to protocol LMB96. Pregnancy and tumorogenesis share some important events such as immunologic tolerance, angiogenesis, and editing the host immune response. Little is known about the relationship between these events in pregnancy and in tumorogenesis.
authors.affiliation: Egas Moniz, Health Sciences Institute, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal.
authors.forename: Carlos
authors.initials: C
authors.lastname: Zagalo
authors.forename: Francesca
authors.initials: F
authors.lastname: Pierdomenico
authors.forename: José
authors.initials: J
authors.lastname: Cabeçadas
authors.forename: Pedro
authors.initials: P
authors.lastname: David Santos