title: Inside-out connections: the ER meets the plasma membrane.
abstract: Junctions that connect the endoplasmic reticulum (ER) and the plasma membrane (PM) are unique yet ubiquitous subcellular compartments. Giordano et al. now report that extended synaptotagmins (E-Syts) promote their formation, providing fundamental insight into the molecular machinery controlling ER and plasma membrane crosstalk.
authors.affiliation: Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Seth
authors.initials: S
authors.lastname: Malmersjö
authors.forename: Tobias
authors.initials: T
authors.lastname: Meyer
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism*; D050857:Synaptotagmins / Q000378:metabolism*
chemical_list: C583132:ESYT1 protein, human; C573315:ESYT2 protein, human; C571229:ESYT3 protein, human; D019269:Phosphatidylinositol 4,5-Diphosphate; D050857:Synaptotagmins; D002118:Calcium