title: Microencapsulation of Traditional Chinese Herbs-PentaHerbs extracts and potential application in healthcare textiles.
abstract: In this work, Traditional Chinese Herbs (TCH)-PentaHerbs--was successfully microencapsulated in chitosan-sodium alginate (CSA) blend matrix using emulsion-chemical cross-linking method and the final product was characterised with regard to structure, surface morphology, particle size, in vitro drug release and skin toxicity by means of Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), laser diffraction particle size analysis, high performance liquid chromatography (HPLC) and methyl thiazolyl tetrazolium (MTT) and lactate dehydrogenase (LDH) release assays respectively. Results showed that the microcapsules were in spherical form with diameter mostly in the range of 3-18 μm and that the release performance of the microcapsules was influenced by pH value of phosphate buffer solution (PBS). The microcapsules had no toxic effects on cells and were successfully grafted onto the surface of cotton fabrics. These results indicated that PentaHerbs loaded CSA microcapsule may possess potential application in clinical treatment of atopic dermatitis (AD).
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
authors.forename: Patrick Chi-Leung
authors.initials: PC
authors.lastname: Hui
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Wang
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. Electronic address: tccwk@polyu.edu.hk.
authors.forename: Chi-Wai
authors.initials: CW
authors.lastname: Kan
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
authors.forename: Frency Sau-Fun
authors.initials: FS
authors.lastname: Ng
authors.affiliation: Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Elaine
authors.initials: E
authors.lastname: Wat
authors.affiliation: Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Vanilla Xin
authors.initials: VX
authors.lastname: Zhang
authors.affiliation: Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Chung-Lap
authors.initials: CL
authors.lastname: Chan
authors.affiliation: Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Clara Bik-San
authors.initials: CB
authors.lastname: Lau
authors.affiliation: Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Leung
mesh_terms: D000464:Alginates / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry; D032561:Cotton Fiber; D003695:Delivery of Health Care; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D005707:Gallic Acid / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D010316:Particle Size; D010936:Plant Extracts / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013784:Textiles
chemical_list: D000464:Alginates; D004365:Drugs, Chinese Herbal; D006603:Hexuronic Acids; D010936:Plant Extracts; D005707:Gallic Acid; D020723:Glucuronic Acid; D048271:Chitosan; D007770:L-Lactate Dehydrogenase
keywords: Atopic dermatitis; Healthcare textiles; Microencapsulation; PentaHerbs