title: Surgical management of fibrotic encapsulation of the fluocinolone acetonide implant in CAPN5-associated proliferative vitreoretinopathy.
abstract: OBJECTIVE
  To review fibrosis of fluocinolone acetonide (FA) implants in subjects with CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV).
  
  
  METHODS
  A retrospective case series was assembled from ADNIV patients in which there was fibrotic encapsulation of a fluocinolone acetonide implant. CAPN5 genotypes and surgical repair techniques were reviewed.
  
  
  RESULTS
  Two eyes of two ADNIV patients developed a fibrotic capsule over the fluocinolone acetonide implant. Both patients had Stage IV disease. Patient A had a c.731T > C mutation in the CAPN5 gene and patient B had a c.728G > T mutation. The fibrotic membrane was surgically excised and the implant function was restored.
  
  
  CONCLUSIONS
  The exuberant fibrotic response in later stages of ADNIV may be resistant to local immunosuppression with steroids. Surgical excision of fibrotic membranes over FA implants can reestablish local steroid delivery in cases of severe proliferative vitreoretinopathy.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Tlucek
authors.forename: James C
authors.initials: JC
authors.lastname: Folk
authors.forename: Warren M
authors.initials: WM
authors.lastname: Sobol
authors.forename: Vinit B
authors.initials: VB
authors.lastname: Mahajan
keywords: ADNIV; CAPN5; Retisert; autosomal dominant neovascular inflammatory vitreoretinopathy; calpain-5; fibrotic encapsulation; fluocinolone acetonide