title: Activation of NF-κB in Schwann cells is dispensable for myelination in vivo.
abstract: Peripheral myelination is a dynamic process orchestrated by axons and Schwann cells. Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro. Using a mouse model, we show that nuclear factor κB activation in Schwann cells is not required for myelination in vivo.
authors.affiliation: The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Morton
authors.forename: Anna
authors.initials: A
authors.lastname: Dellarole
authors.forename: Michelle H
authors.initials: MH
authors.lastname: Theus
authors.forename: Winston M
authors.initials: WM
authors.lastname: Walters
authors.forename: Summer S
authors.initials: SS
authors.lastname: Berge
authors.forename: John R
authors.initials: JR
authors.lastname: Bethea
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000201:enzymology; D004195:Disease Models, Animal; D004622:Embryo, Mammalian; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D051550:I-kappa B Kinase / Q000172:deficiency / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D004676:Myelin Basic Protein; D018993:Myelin P0 Protein / Q000235:genetics / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism; D012583:Schwann Cells / Q000201:enzymology* / Q000378:metabolism; D012584:Sciatic Nerve / Q000378:metabolism / Q000473:pathology; D020426:Sciatic Neuropathy / Q000150:complications / Q000473:pathology; D013997:Time Factors; D014855:Wallerian Degeneration / Q000209:etiology / Q000473:pathology
chemical_list: C110853:Gt(ROSA)26Sor non-coding RNA, mouse; C560546:Mpz protein, mouse; D004676:Myelin Basic Protein; D018993:Myelin P0 Protein; D016328:NF-kappa B; D009414:Nerve Growth Factors; D011506:Proteins; D022661:RNA, Untranslated; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D051550:I-kappa B Kinase