title: Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat.
abstract: Diabetic encephalopathy (DE) has been characterized by the impaired cognition and the abnormalities of neurochemistry and neurostructure. The study was conducted to evaluate the neuroprotective effect of paeonol on STZ-induced DE rats. Paeonol of 25, 50, 100mg/kg (p.o.) could decrease the latency time and path length, and enhance significantly the spent time in the target quadrant and platform crossings in Morris water maze test. The treatment with paeonol could also increase significantly Na(+)-K(+)-ATP enzyme and ChAT activities, as well as decreasing significantly AchE activity in hippocampal tissue. Immunohistochemistry and TUNEL staining showed that paeonol could attenuate apoptosis of neurons and caspase 3 expression, improve two neurotrophic factors BDNF and IGF expressions, and also ameliorate Aβ deposition in the hippocampus and cerebral cortex. In conclusion, the present study demonstrated diabetic rats treated with paeonol could ameliorate the cognition deficits. These findings indicated paeonol might act as a beneficial agent for the prevention and treatment of DE.
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
authors.forename: Jiping
authors.initials: J
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Feng
authors.forename: Dongying
authors.initials: D
authors.lastname: Ma
authors.forename: Minghua
authors.initials: M
authors.lastname: Zhang
authors.forename: Junfei
authors.initials: J
authors.lastname: Gu
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.forename: Yu
authors.initials: Y
authors.lastname: Song
authors.forename: Zhou
authors.initials: Z
authors.lastname: Lan
authors.forename: Rong
authors.initials: R
authors.lastname: Qu
authors.forename: Shiping
authors.initials: S
authors.lastname: Ma
mesh_terms: D000098:Acetophenones / Q000494:pharmacology / Q000627:therapeutic use*; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D053148:Caspase 3 / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000098:Acetophenones; D019208:Brain-Derived Neurotrophic Factor; D018696:Neuroprotective Agents; C013638:paeonol; D007334:Insulin-Like Growth Factor I; D000110:Acetylcholinesterase; D053148:Caspase 3
keywords: AChE; Anti-apoptosis; Aβ; BDNF; ChAT; Cognition deficits; DE; Diabetic encephalopathy; HGF; IGF; Na(+)-K(+)-ATPase; Na(+)-K(+)-adenosine triphosphatase; Neuropathological changes; Paeonol; STZ; acetylcholinesterase; amyloid beta; brain derived neurotrophic factor; choline acetyltransferase; diabetic encephalopathy; high-glucose-fat diet; insulin-like growth factors; streptozotocin; β-amyloid