title: Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation.
abstract: Chemoradiotherapy can induce immunogenic cell death, triggering danger signals such as high-mobility group box 1 protein, and resulting in T-cell immunity. This concept can potentially be harnessed for clinical therapy to enhance tumor-specific immunity. There is however limited information to translate this theory directly in a clinical setting. In this review, we will discuss and summarize molecular and cellular mechanisms underlying immunogenic tumor cell death induced by chemoradiotherapy, with emphasis on a clinical translation.
authors.affiliation: Department of Surgery, National University of Singapore, Singapore. surkoji@nus.edu.sg
authors.forename: K
authors.initials: K
authors.lastname: Kono
authors.forename: K
authors.initials: K
authors.lastname: Mimura
authors.forename: R
authors.initials: R
authors.lastname: Kiessling
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D037282:Calreticulin / Q000378:metabolism; D059248:Chemoradiotherapy; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D024243:HMGB1 Protein / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects; D051197:Toll-Like Receptor 4 / Q000378:metabolism; D057170:Translational Research, Biomedical
chemical_list: D000951:Antigens, Neoplasm; D037282:Calreticulin; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4