title: Migration of Ag- and TiO2-(Nano)particles from textiles into artificial sweat under physical stress: experiments and exposure modeling.
abstract: Engineered nanoparticles (ENP) are increasingly used to functionalize textiles taking advantage, e.g., of the antimicrobial activity of silver (Ag)-ENP or the UV-absorption of titania (TiO2)-ENP. Mobilization and migration of ENPs from the textile into human sweat can result in dermal exposure to these nanoobjects and their aggregates and agglomerates (NOAA). In this study we assessed exposure to NOAA migrating from commercially available textiles to artificial sweat by an experimental setup that simulates wear-and-tear during physical activity. By combining physical stress with incubation in alkaline and acidic artificial sweat solutions we experimentally realized a worst case scenario for wearing functionalized textiles during sports activities. This experimental approach is not limited to NOAA, but can be used for any other textile additive. Out of four investigated textiles, one T-shirt and one pair of trousers with claimed antimicrobial properties were found to release Ag <450 nm in detectable amounts (23-74 μg/g/L). Textiles containing TiO2 for UV protection did not release significant amounts of TiO2 <450 nm, but the antimicrobial T-shirt released both TiO2 and Ag <450 nm. The silver was present in dissolved and particulate form, whereas TiO2 was mainly found as particulate. On the basis of our experimental results we calculated external dermal exposure to Ag and TiO2 for male and female adults per use. For silver, maximal amounts of 17.1 and 8.2 μg/kg body weight were calculated for total and particulate Ag <450 nm, respectively. For TiO2, the exposure levels amount to maximal 11.6 μg/kg body weight for total (mainly particulate) TiO2. In comparison with other human exposure pathways, dermal exposure to NOAA from textiles can be considered comparably minor for TiO2-NOAA, but not for Ag-NOAA.
authors.affiliation: ETH Zürich, Institute for Chemical and Bioengineering, 8093 Zürich, Switzerland. natalie.von.goetz@chem.ethz.ch
authors.forename: N
authors.initials: N
authors.lastname: von Goetz
authors.forename: C
authors.initials: C
authors.lastname: Lorenz
authors.forename: L
authors.initials: L
authors.lastname: Windler
authors.forename: B
authors.initials: B
authors.lastname: Nowack
authors.forename: M
authors.initials: M
authors.lastname: Heuberger
authors.forename: K
authors.initials: K
authors.lastname: Hungerbühler
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000032:analysis* / Q000737:chemistry; D003020:Clothing; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D053768:Metal Nanoparticles / Q000032:analysis* / Q000737:chemistry; D017348:Microscopy, Electron, Scanning Transmission; D008962:Models, Theoretical; D009043:Motor Activity; D012834:Silver / Q000032:analysis / Q000737:chemistry; D013054:Spectrophotometry, Atomic / Q000379:methods*; D013473:Sunscreening Agents / Q000032:analysis* / Q000737:chemistry; D013542:Sweat / Q000737:chemistry*; D014025:Titanium / Q000032:analysis / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D013473:Sunscreening Agents; C009495:titanium dioxide; D012834:Silver; D014025:Titanium