title: Meta-analysis of the relation between vitamin D receptor gene BsmI polymorphism and susceptibility to ovarian cancer.
abstract: The role of vitamin D receptor (VDR) BsmI polymorphism in ovarian cancer development has been studied in various populations, but those results are discordant controversial and ambiguous. Thus, we performed a meta-analysis to assess the association between VDR BsmI polymorphism and susceptibility to ovarian cancer more precisely. Odds ratio (OR) and its 95% confidence interval (95% CI) were used for statistical analysis. Nine individual studies with a total 2,331 cases and 3,301 controls were included into this meta-analysis. There was no heterogeneity among those nine studies. Meta-analysis of total nine studies suggested that there was no association between VDR BsmI polymorphism and susceptibility to ovarian cancer (B vs. b, OR = 1.02, 95% CI = 0.94-1.10, P = 0.616, I(2) = 0%; BB vs. bb, OR = 1.02, 95 % CI = 0.87-1.20, P = 0.810, I(2) = 0 %; BB/Bb vs. bb, OR = 1.05, 95% CI = 0.94-1.18, P = 0.391, I(2) = 0 %; BB vs. bb/Bb, OR = 0.99, 95% CI = 0.85-1.14, P = 0.853, I(2) = 0 %). Meta-analysis of seven studies from Caucasians also showed that there was no association between VDR BsmI polymorphism and susceptibility to ovarian cancer. This meta-analysis suggests that there is no association between VDR BsmI polymorphism and susceptibility to ovarian cancer in Caucasians. Future studies from Asians or Africans are needed to further assess the above association.
authors.affiliation: Department of Gynecology, Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Sheng-Chun
authors.initials: SC
authors.lastname: Tong
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Guan
authors.forename: Fei
authors.initials: F
authors.lastname: Na
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Wei
mesh_terms: D001665:Binding Sites / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D018167:Receptors, Calcitriol; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific