title: Influence of particle size of deproteinized bovine bone mineral on new bone formation and implant stability after simultaneous sinus floor elevation: a histomorphometric study in minipigs.
abstract: BACKGROUND
  Deproteinized bovine bone mineral (DBBM) is one of the best-documented bone substitute materials for sinus floor elevation (SFE).
  
  
  OBJECTIVE
  DBBM is available in two particle sizes. Large particles are believed to facilitate improved neoangiogenesis compared with small ones. However, their impact on the rate of new bone formation, osteoconduction, and DBBM degradation has never been reported. In addition, the implant stability quotient (ISQ) has never been correlated to bone-to-implant contact (BIC) after SFE with simultaneous implant placement.
  
  
  METHODS
  Bilateral SFE with simultaneous implant placement was performed in 10 Göttingen minipigs. The two sides were randomized to receive large or small particle size DBBM. Two groups of 5 minipigs healed for 6 and 12 weeks, respectively. ISQ was recorded immediately after implant placement and at sacrifice. Qualitative histological differences were described and bone formation, DBBM degradation, BIC and bone-to-DBBM contact (osteoconduction) were quantified histomorphometrically.
  
  
  RESULTS
  DBBM particle size had no qualitative or quantitative impact on the amount of newly formed bone, DBBM degradation, or BIC for either of the healing periods (p > 0.05). Small-size DBBM showed higher osteoconduction after 6 weeks than large-size DBBM (p < 0.001). After 12 weeks this difference was compensated. There was no significant correlation between BIC and ISQ.
  
  
  CONCLUSIONS
  Small and large particle sizes were equally predictable when DBBM was used for SFE with simultaneous implant placement.
authors.affiliation: Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland; Department of Oral and Maxillofacial Surgery, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Jensen
authors.forename: Merete
authors.initials: M
authors.lastname: Aaboe
authors.forename: Simone F M
authors.initials: SF
authors.lastname: Janner
authors.forename: Nikola
authors.initials: N
authors.lastname: Saulacic
authors.forename: Michael M
authors.initials: MM
authors.lastname: Bornstein
authors.forename: Dieter D
authors.initials: DD
authors.lastname: Bosshardt
authors.forename: Daniel
authors.initials: D
authors.lastname: Buser
mesh_terms: D000818:Animals; D002417:Cattle; D003094:Collagen / Q000494:pharmacology; D003758:Dental Implantation, Endosseous / Q000379:methods*; D008903:Minerals / Q000494:pharmacology*; D016348:Osseointegration; D010012:Osteogenesis / Q000187:drug effects*; D010316:Particle Size; D059546:Sinus Floor Augmentation / Q000379:methods*; D013552:Swine; D013556:Swine, Miniature
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D008903:Minerals; D003094:Collagen
keywords: animal study; bone substitutes; histological analysis; implant stability; sinus floor elevation