title: Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin involvement: a case report and review of literature.
abstract: No standard treatment has been established in childhood blastic plasmacytoid dendritic cell neoplasma (BPDCN) because of its rarity. We treated with acute lymphoblastic leukemia-type regimen for a child with BPDCN with skin and leukemic involvement. She has been disease-free for 4 years after allogeneic bone marrow transplantation in first complete remission. In 33 cases of pediatric BPDCN, the over survival was significantly lower in the patients with skin manifestation than those without cutaneous involvement. Accordingly, it is important to determine whether allogeneic hematopoietic stem cell transplantation should be applied to first complete remission in the patients with poor prognosis.
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sakashita
authors.forename: Shoji
authors.initials: S
authors.lastname: Saito
authors.forename: Ryu
authors.initials: R
authors.lastname: Yanagisawa
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Tsukahara
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Motobayashi
authors.forename: Yozo
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Koike
mesh_terms: D002675:Child, Preschool; D003713:Dendritic Cells / Q000473:pathology*; D005260:Female; D019337:Hematologic Neoplasms / Q000473:pathology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D014184:Transplantation, Homologous
keywords: blastic plasmacytoid dendritic cell neoplasm; bone marrow transplantation; childhood; skin involvement