title: [A case report of pulmonary aspergillosis in lung transplant recipient successfully treated with inhalation administration of liposomal amphotericin B].
abstract: We report a case of pulmonary aspergillosis in lung transplant recipient who was successfully treated with inhalation administration of anti-fungal agent. The case was 33-year-old female. Two years ago, she had received lung transplant because of lymphangioleiomyomatosis. One year ago, she had diagnosed of pulmonary aspergillosis and successfully treated with micafungin and itraconazole. Then she had been continuous administered with itraconazole. In June 20xx, she had nausea and vomiting and was diagnosed of viral enteritis. Although abdominal symptoms were relieved, ground glass opacity was discovered in her right lung. Bronchoscopic examination revealed ulceration of bronchus with white necrotic substance. Laboratory culture test demonstrated Aspergillus spp. Finally she was diagnosed of recurrent pulmonary aspergillosis. First, she was treated with intravascular administration of micafungin. Then, inhalation administration of liposomal amphotericin B was changed. Ground glass opacity and bronchial region of pulmonary aspergillosis was improved. Thereafter, inhalation of amphotericin B was continued and no recurrence of pulmonary aspergillosis has been found. Inhalation of anti-fungal agent could be an option for pulmonary aspergillosis.
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Hospital.
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujita
authors.forename: Jun
authors.initials: J
authors.lastname: Yanagisawa
authors.forename: Masafumi
authors.initials: M
authors.lastname: Hiratsuka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Hirano
authors.forename: Takemasa
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Motokimi
authors.initials: M
authors.lastname: Shiraishi
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwasaki
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D055732:Pulmonary Aspergillosis / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B