title: Novel and simple prognostic index for nasal natural killer/T-cell lymphoma.
abstract: BACKGROUND
  Few studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma.
  
  
  METHODS
  This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals.
  
  
  RESULTS
  High serum levels of C-reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin-2 receptor (sIL-2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease-specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2.
  
  
  CONCLUSIONS
  Our NPI is valid for anticipating prognosis of nasal NK/T-cell lymphoma.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hanakawa
authors.forename: Yorihisa
authors.initials: Y
authors.lastname: Orita
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Sato
authors.forename: Soshi
authors.initials: S
authors.lastname: Takao
authors.forename: Hidenori
authors.initials: H
authors.lastname: Marunaka
authors.forename: Tokiwa
authors.initials: T
authors.lastname: Morishita
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Hori
authors.forename: Shuhei
authors.initials: S
authors.lastname: Domae
authors.forename: Ikuo
authors.initials: I
authors.lastname: Inokuchi
authors.forename: Seiko
authors.initials: S
authors.lastname: Akagi
authors.forename: Eisei
authors.initials: E
authors.lastname: Kondo
authors.forename: Noriko
authors.initials: N
authors.lastname: Iwaki
authors.forename: Kana
authors.initials: K
authors.lastname: Motomiya
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Okumura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nishizaki
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D054391:Lymphoma, Extranodal NK-T-Cell / Q000097:blood / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology; D009361:Neoplasm Invasiveness; D009669:Nose Neoplasms / Q000097:blood / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D015375:Receptors, Interleukin-2 / Q000097:blood; D012189:Retrospective Studies
chemical_list: D015375:Receptors, Interleukin-2; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase
keywords: blood examination; local invasion; nasal NK/T-cell lymphoma; prognosis; prognostic index