title: Preparing for your future as you grow.
abstract: Commissural axons cross the nervous system midline and connect to targets in the contralateral hemisphere. In this issue of Neuron, Michalski et al. (2013) demonstrate that synapses formed by ipsilaterally misrouted commissural axons exhibit defects in synapse maturation. Thus, midline crossing primes axons for subsequent synaptogenesis.
authors.affiliation: Biozentrum of the University of Basel, CH-4056 Basel, Switzerland. peter.scheiffele@unibas.ch
authors.forename: Peter
authors.initials: P
authors.lastname: Scheiffele
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D001933:Brain Stem / Q000166:cytology*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface; D013569:Synapses / Q000502:physiology*; D000097905:Roundabout Proteins
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; C118348:Robo3 protein, mouse; D000097905:Roundabout Proteins