title: Improvement of biochemical parameters in type 1 diabetic rats after the roots aqueous extract of yacon [Smallanthus sonchifolius (Poepp.& Endl.)] treatment.
abstract: The aim of this study was to evaluate the effect of yacon (Smallanthus sonchifolius) (Poepp.& Endl.) on clinical parameters under diabetic conditions. The aqueous extract of yacon tuberous roots (YRAE; 0.76 g fructan kg⁻¹ body weight) was prepared at the moment of each administration. Thirty-two male rats were divided into four groups (n=8): control group (C); group that received YRAE (Y); untreated diabetic group (DM1); and diabetic group treated with YRAE (Y-DM1). The diabetes mellitus was induced by streptozotocin (60 mg kg⁻¹ body weight). The animals from Y2 and Y-DM1 received YRAE by gavage, at 7-day intervals, for 30 days. The aqueous extract of yacon roots decreased (p<0.05) the water and food intake in diabetic rats (Y-DM1). YRAE treatment reduced (p<0.05) glycaemia, total cholesterol, VLDL-c, LDL-c and triacylglycerol levels in diabetic rats (YRAE). HDL, urea and creatinine levels did not differ (p>0.05) between the Y and Y-DM1 groups. YRAE normalised alanine aminotransferase (ALT) activity, when comparing DM1 and Y-DM1 rats, but had no effect on lactate dehydrogenase activity (LDH). In conclusion, YRAE was sufficient for controlling water and food consumption, hyperglycaemia and dyslipidaemia, and promote the reduction of the ALT, suggesting a hepatoprotective effect in rats with STZ-induced DM1.
authors.affiliation: Residency Internal Medicine Departamento Clínica Médica, Faculdade de Medicina de Botucatu, Botucatu, Brazil.
authors.forename: Gilberto Ornelas
authors.initials: GO
authors.lastname: Oliveira
authors.forename: Camila Pereira
authors.initials: CP
authors.lastname: Braga
authors.forename: Ana Angélica Henrique
authors.initials: AA
authors.lastname: Fernandes
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001938:Brazil; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D050171:Dyslipidemias / Q000150:complications / Q000517:prevention & control; D002149:Energy Intake / Q000187:drug effects; D020834:Ethnopharmacology; D005630:Fructans / Q000032:analysis; D048550:Hepatic Insufficiency / Q000150:complications / Q000517:prevention & control; D006943:Hyperglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008519:Medicine, Traditional; D008517:Phytotherapy / Q000009:adverse effects; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015431:Weight Loss / Q000187:drug effects
chemical_list: D005630:Fructans; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D010936:Plant Extracts
keywords: Diabetes mellitus; Fructans; Metabolism; Streptozotocin; Yacon