title: Determination of steroids, caffeine and methylparaben in water using solid phase microextraction-comprehensive two dimensional gas chromatography-time of flight mass spectrometry.
abstract: Analysis of several emerging contaminants (steroids, caffeine and methylparaben) in water using automated solid-phase microextraction with comprehensive two dimensional gas chromatography coupled to time of flight mass spectrometry (SPME-GCxGC-ToF/MS) is presented. Experimental design was used to determine the best SPME extraction conditions and the steroids were not derivatized prior to injection. SPME-GCxGC-ToF/MS provided linear ranges from 0.6 to 1200μgL(-1) and limits of detection and quantitation from 0.02 to 100μgL(-1). A series of river water samples obtained locally were subjected to analysis. SPME-GCxGC-ToF/MS is readily automated, straightforward and competitive with other methods for low level analysis of emerging contaminants.
authors.affiliation: Institute of Chemistry of Sao Carlos, University of Sao Paulo, Postal Code 780, 13560-970 São Carlos, SP, Brazil.
authors.forename: Paulo C F
authors.initials: PC
authors.lastname: Lima Gomes
authors.forename: Brian B
authors.initials: BB
authors.lastname: Barnes
authors.forename: Álvaro J
authors.initials: ÁJ
authors.lastname: Santos-Neto
authors.forename: Fernando M
authors.initials: FM
authors.lastname: Lancas
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Snow
mesh_terms: D002110:Caffeine / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010226:Parabens / Q000032:analysis*; D052617:Solid Phase Microextraction / Q000379:methods*; D013256:Steroids / Q000032:analysis*; D014867:Water / Q000032:analysis*
chemical_list: D010226:Parabens; D013256:Steroids; D014867:Water; D002110:Caffeine; C015358:methylparaben