title: Incremental value of magnetic resonance imaging for clinically high risk prostate cancer in 922 radical prostatectomies.
abstract: OBJECTIVE
  We investigated the incremental value of magnetic resonance imaging in addition to clinical variables for predicting pathological outcomes and disease recurrence in patients with clinically high risk prostate cancer.
  
  
  METHODS
  A total of 922 consecutive patients with clinically high risk prostate cancer underwent magnetic resonance imaging before radical prostatectomy. We created multivariate logistic regression and Cox proportional hazards models with clinical variables only or combined with magnetic resonance imaging data to predict pathological outcomes and biochemical recurrence. The models were compared using ROC curves and the Harrell concordance index.
  
  
  RESULTS
  The proportion of patients with pathological extracapsular extension, seminal vesicle invasion and lymph node metastasis was 57.5%, 12.7% and 6.3%, respectively. The sensitivity and specificity of extracapsular extension, seminal vesicle invasion and lymph node metastasis detection were 43% and 84.2%, 34.9% and 93.8%, and 14.0% and 96.9%, respectively. The area under the ROC curve of the model with clinical variable and magnetic resonance imaging data was greater than that of the model with clinical variables alone to predict extracapsular extension and seminal vesicle invasion (0.734 vs 0.697, p=0.001 and 0.750 vs 0.698, p<0.001, respectively). The 5-year biochemical recurrence-free survival rate was 56.1%. To predict biochemical recurrence the concordance index of the multivariate model with clinical variables only and with clinical variables plus magnetic resonance imaging data was 0.563 and 0.599, respectively (p=0.003).
  
  
  CONCLUSIONS
  Magnetic resonance imaging findings have incremental value in addition to clinical variables for predicting pathological outcomes and disease recurrence.
authors.affiliation: Departments of Urology and Radiology (MHK, HJC, JKK, KSC), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: In Gab
authors.initials: IG
authors.lastname: Jeong
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Lim
authors.forename: Dalsan
authors.initials: D
authors.lastname: You
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Kim
authors.forename: Hyuk Jae
authors.initials: HJ
authors.lastname: Choi
authors.forename: Jeong Kon
authors.initials: JK
authors.lastname: Kim
authors.forename: Kyoung-Sik
authors.initials: KS
authors.lastname: Cho
authors.forename: Jun Hyuk
authors.initials: JH
authors.lastname: Hong
authors.forename: Hanjong
authors.initials: H
authors.lastname: Ahn
authors.forename: Choung-Soo
authors.initials: CS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D018570:Risk Assessment
keywords: AUC; BCR; DW; ECE; MR; PSA; RP; SVI; area under ROC curve; biochemical recurrence; c-index; concordance index; diffusion-weighted; extracapsular extension; magnetic resonance; magnetic resonance imaging; prognosis; prostate; prostate specific antigen; prostatectomy; prostatic neoplasms; radical prostatectomy; seminal vesicle invasion