title: 14-3-3ɛ/ζ Affects the stability of δ-catenin and regulates δ-catenin-induced dendrogenesis.
abstract: Accumulated evidence suggests that aberrant regulation of δ-catenin leads to pathological consequences such as mental retardation and cognitive dysfunction. This study revealed that 14-3-3ɛ/ζ stabilizes δ-catenin, with different binding regions involved in the interaction. Furthermore, the specific inhibition of the interaction of 14-3-3 with δ-catenin reduced levels of δ-catenin and significantly impaired the capacity of δ-catenin to induce dendritic branching in both NIH3T3 fibroblasts and primary hippocampal neurons. However, the S1094A δ-catenin mutant, which cannot interact with 14-3-3ζ, still retained the capability of inducing dendrogenesis. Taken together, these results elucidate the underlying events that regulate the stability of δ-catenin and δ-catenin-induced dendrogenesis.
authors.affiliation: College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: He
authors.forename: Jeong Ran
authors.initials: JR
authors.lastname: Han
authors.forename: Ockyoung
authors.initials: O
authors.lastname: Chang
authors.forename: Minsoo
authors.initials: M
authors.lastname: Oh
authors.forename: Sarah E
authors.initials: SE
authors.lastname: James
authors.forename: Qun
authors.initials: Q
authors.lastname: Lu
authors.forename: Young-Woo
authors.initials: YW
authors.lastname: Seo
authors.forename: Hangun
authors.initials: H
authors.lastname: Kim
authors.forename: Kwonseop
authors.initials: K
authors.lastname: Kim
keywords: 14-3-3; Dendrogenesis; Neuron; Protein stability; δ-Catenin