title: Enantioselective aza-Michael addition of imides by using an integrated strategy involving the synthesis of a family of multifunctional catalysts, usage of multiple catalysis, and rational design of experiment.
abstract: A challenging asymmetric reaction (aza-Michael addition of imides to enones) has been optimized through an integrated approach involving the synthesis of a family of organocatalysts, multiple catalysis (usage of additives), and finally with rational exploration of the chemical space by the application of the experiment design.
authors.affiliation: Department of Chemistry, Sapienza University of Roma, P.le Aldo Moro 5, 00185 Roma, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Silvi
authors.forename: Polyssena
authors.initials: P
authors.lastname: Renzi
authors.forename: Deborah
authors.initials: D
authors.lastname: Rosato
authors.forename: Cristiana
authors.initials: C
authors.lastname: Margarita
authors.forename: Alessio
authors.initials: A
authors.lastname: Vecchioni
authors.forename: Ivan
authors.initials: I
authors.lastname: Bordacchini
authors.forename: Diego
authors.initials: D
authors.lastname: Morra
authors.forename: Alessandro
authors.initials: A
authors.lastname: Nicolosi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Cari
authors.forename: Fabio
authors.initials: F
authors.lastname: Sciubba
authors.forename: Daniele M
authors.initials: DM
authors.lastname: Scarpino Schietroma
authors.forename: Marco
authors.initials: M
authors.lastname: Bella
keywords: asymmetric catalysis; aza-Michael reaction; enones; imides; synthetic methods