title: Total synthesis and stereochemical assignment of baringolin.
abstract: The thiopeptide antibiotic baringolin has been synthesized, and its structure and stereochemistry have been confirmed. The use of a strategy based on palladium-catalyzed cross-couplings permitted a modular construction of this natural product.
authors.affiliation: Institute for Research in Biomedicine, Barcelona Science Park-University of Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Just-Baringo
authors.forename: Paolo
authors.initials: P
authors.lastname: Bruno
authors.forename: Lars K
authors.initials: LK
authors.lastname: Ottesen
authors.forename: Librada M
authors.initials: LM
authors.lastname: Cañedo
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Mercedes
authors.initials: M
authors.lastname: Álvarez
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010446:Peptide Fragments; D010456:Peptides, Cyclic; D011725:Pyridines; D013438:Sulfhydryl Compounds; C583833:baringolin
keywords: antibiotics; cross-couplings; heterocycles; natural products; thiopeptides