title: Autoantibodies against complement components and functional consequences.
abstract: The complement system represents a major component of our innate immune defense. Although the physiological contribution of the complement system is beneficial, it can cause tissue damage when inappropriately activated or when it is a target of an autoantibody response. Autoantibodies directed against a variety of individual complement components, convertases, regulators and receptors have been described. For several autoantibodies the functional consequences are well documented and clear associations exist with clinical presentation, whereas for other autoantibodies targeting complement components this relation is currently insufficiently clear. Several anti-complement autoantibodies can also be detected in healthy controls, indicating that a second hit is required for such autoantibodies to induce or participate in pathology or alternatively that these antibodies are part of the natural antibody repertoire. In the present review, we describe autoantibodies against complement components and their functional consequences and discuss about their clinical relevance.
authors.affiliation: INSERM UMRS 872, Cordeliers Research Center, Paris, France.
authors.forename: Marie-Agnès
authors.initials: MA
authors.lastname: Dragon-Durey
authors.forename: Caroline
authors.initials: C
authors.lastname: Blanc
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Marinozzi
authors.forename: Rosanne A
authors.initials: RA
authors.lastname: van Schaarenburg
authors.forename: Leendert A
authors.initials: LA
authors.lastname: Trouw
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D050577:Complement C3-C5 Convertases / Q000276:immunology; D017242:Complement Factor H / Q000276:immunology; D003170:Complement Pathway, Alternative / Q000276:immunology; D003171:Complement Pathway, Classical / Q000276:immunology; D037582:Complement Pathway, Mannose-Binding Lectin / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D006801:Humans; D011951:Receptors, Complement / Q000276:immunology
chemical_list: D001323:Autoantibodies; D011951:Receptors, Complement; D017242:Complement Factor H; D003165:Complement System Proteins; D050577:Complement C3-C5 Convertases
keywords: Autoantibodies; C1q; Complement; Factor H