title: Ceruloplasmin and the extent of heart failure in ischemic and nonischemic cardiomyopathy patients.
abstract: OBJECTIVE
  Ceruloplasmin was elevated in patients with coronary heart disease, but the relationship between ceruloplasmin and heart failure was still unknown. We aimed to evaluate ceruloplasmin in heart failure patients and assess association between ceruloplasmin and the extent of heart failure.
  
  
  RESULTS
  202 heart failure patients were divided into ischemic (78 with coronary stenosis) and nonischemic groups (124 without coronary stenosis). 94 subjects without heart failure were included as controls. The extent of heart failure was defined according to NYHA classification. Ceruloplasmin levels in ischemic (P < 0.001) and nonischemic groups (P < 0.001) were higher than those in control group. Ceruloplasmin had a positive linear correlation with C-reactive protein (P < 0.01) and a negative linear correlation with LVEF (P < 0.05). In nonischemic group, CP levels were significantly different among different NYHA subgroups (P < 0.05). The correlation between ceruloplasmin and extent of heart failure was calculated by binary logistic regression. Ceruloplasmin showed an independent association with the extent of heart failure in nonischemic cardiomyopathy patients (P < 0.05).
  
  
  CONCLUSIONS
  Ceruloplasmin was significantly elevated in patients with ischemic or nonischemic cardiomyopathy and had linear correlation with C-reactive protein and LVEF. In nonischemic cardiomyopathy patients, the ceruloplasmin value was an independent biomarker associated with the extent of heart failure.
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Zhejiang University, College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Xu
authors.forename: Haiyan
authors.initials: H
authors.lastname: Lin
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D009202:Cardiomyopathies / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism; D023921:Coronary Stenosis / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged
chemical_list: D002097:C-Reactive Protein; D002570:Ceruloplasmin