title: [Recommendations for the diagnosis of candidemia in Latin America. Grupo Proyecto Épico].
abstract: Candidemia is one of the most frequent opportunistic mycoses worldwide. Limited epidemiological studies in Latin America indicate that incidence rates are higher in this region than in the Northern Hemisphere. Diagnosis is often made late in the infection, affecting the initiation of antifungal therapy. A more scientific approach, based on specific parameters, for diagnosis and management of candidemia in Latin America is warranted. 'Recommendations for the diagnosis and management of candidemia' are a series of manuscripts that have been developed by members of the Latin America Invasive Mycosis Network. They aim to provide a set of best-evidence recommendations for the diagnosis and management of candidemia. This publication, 'Recommendations for the diagnosis of candidemia in Latin America', was written to provide guidance to healthcare professionals on the diagnosis of candidemia, as well as on the usefulness and application of susceptibility testing in patients who have a confirmed diagnosis of candidemia. Computerized searches of existing literature were performed by PubMed. The data were extensively reviewed and analyzed by members of the group. The group also met on two occasions to pose questions, discuss conflicting views, and deliberate on a series of management recommendations. 'Recommendations for the diagnosis of candidemia in Latin America' includes diagnostic methods used to detect candidemia, Candida species identification, and susceptibility testing. The availability of methods, their costs and treatment settings are considered. This manuscript is the first of this series that deals with diagnosis and treatment of invasive candidiasis. Other publications in this series include: 'Recommendations for the management of candidemia in adults in Latin America', 'Recommendations for the management of candidemia in children in Latin America', and 'Recommendations for the management of candidemia in neonates in Latin America'.
authors.affiliation: Federal University of São Paulo, São Paulo, Brasil; Latin America Invasive Mycosis Network. Electronic address: colomboal@terra.com.br.
authors.forename: Arnaldo Lopes
authors.initials: AL
authors.lastname: Colombo
authors.forename: Jorge Alberto
authors.initials: JA
authors.lastname: Cortes
authors.forename: Jeannete
authors.initials: J
authors.lastname: Zurita
authors.forename: Manuel
authors.initials: M
authors.lastname: Guzman-Blanco
authors.forename: Tito
authors.initials: T
authors.lastname: Alvarado Matute
authors.forename: Flavio
authors.initials: F
authors.lastname: de Queiroz Telles
authors.forename: María E
authors.initials: ME
authors.lastname: Santolaya
authors.forename: Iris Nora
authors.initials: IN
authors.lastname: Tiraboschi
authors.forename: Juan
authors.initials: J
authors.lastname: Echevarría
authors.forename: Jose
authors.initials: J
authors.lastname: Sifuentes
authors.forename: Luis
authors.initials: L
authors.lastname: Thompson-Moya
authors.forename: Marcio
authors.initials: M
authors.lastname: Nucci
mesh_terms: D000946:Antigens, Fungal / Q000097:blood; D001331:Automation; D001706:Biopsy; D001769:Blood / Q000382:microbiology; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D058387:Candidemia / Q000175:diagnosis* / Q000453:epidemiology; D002863:Chromogenic Compounds; D003470:Culture Media; D004696:Endocarditis / Q000000981:diagnostic imaging / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007843:Latin America / Q000453:epidemiology; D008826:Microbial Sensitivity Tests / Q000379:methods; D009172:Mycology / Q000295:instrumentation / Q000379:methods; D016133:Polymerase Chain Reaction / Q000379:methods; D011859:Radiography; D012698:Serologic Tests / Q000379:methods; D013045:Species Specificity; D013194:Staining and Labeling / Q000379:methods; D014463:Ultrasonography
chemical_list: D000946:Antigens, Fungal; D002863:Chromogenic Compounds; D003470:Culture Media
keywords: América Latina; Candidemia; Diagnosis; Diagnóstico; Latin America; Recomendaciones; Recommendations