title: The effect of hyaluronan on the aggregation of hydrophobized amino acids--a fluorescence study.
abstract: The influence of the addition of native hyaluronan of different molecular weights (1.36 MDa and 106 kDa) on the aggregation behavior of hydrophobically modified amino acids in aqueous solution and in 0.15M NaCl was investigated using pyrene as a solubilization probe. Hyaluronan decreased the critical aggregation concentration in aqueous solution in the case of amino acids modified by a single alkyl chain whereas no change was observed in physiological solution. The aggregation of amino acids modified by two alkyl chains was insensitive to the presence of hyaluronan.
authors.affiliation: Brno University of Technology, Faculty of Chemistry, Materials Research Centre, Purkyňova 118, Brno CZ-61200, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Halasová
authors.forename: F
authors.initials: F
authors.lastname: Mravec
authors.forename: M
authors.initials: M
authors.lastname: Pekař
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008970:Molecular Weight; D011721:Pyrenes / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D011721:Pyrenes; D014867:Water; D012965:Sodium Chloride; D006820:Hyaluronic Acid; C030984:pyrene