title: Genomic approaches in breast cancer research.
abstract: Microarray technologies provide high-throughput analysis of genes that are differentially expressed in humans and other species, and thereby provide a means to measure how biological systems are altered during development or disease states. Within, we review how high-throughput genomic technologies have increased our understanding about the molecular complexity of breast cancer, identified distinct molecular phenotypes and how they can be used to increase the accuracy of predicted clinical outcome.
authors.affiliation: Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA. Tel.: +1 530 754 0146; Fax: +1 530 753 7690; dgenetos@ucdavis.edu.
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Donahue
authors.forename: Damian C
authors.initials: DC
authors.lastname: Genetos
mesh_terms: D035843:Biomedical Research; D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods*; D006801:Humans; D060787:Neoplasm Grading; D015398:Signal Transduction / Q000235:genetics
keywords: breast cancer; genomics; histology; microarray; tumor