title: Experience of a monographic tuberculosis unit: the first 500 cases.
abstract: BACKGROUND
  Tuberculosis (TB) remains a highly prevalent and potentially severe disease. However, since 2002 the annual incidence has been decreasing both worldwide and in Spain, where the incidence varies widely between regions. The main objective of this study is to describe the experience of a monographic TB unit in a second level hospital.
  
  
  METHODS
  A descriptive study was carried out which included all cases of TB diagnosed in a monographic unit of a secondary hospital between 2003 and 2011. Demographic, clinical, epidemiological and microbiological data were recorded.
  
  
  RESULTS
  We analyzed 500 TB cases and found an increasing annual incidence in all subgroups, including native and immigrant populations. Most cases (63.8%) were male, with a median age of 36 years (range 8 months-90 years). In total, 39.8% of patients were foreign born. Coinfection with human immunodeficiency virus was found in 11% of cases. The pulmonary form was most frequently diagnosed (63.8%). Overall mortality was 5.8% with no significant differences between groups (including foreign born and human immunodeficiency virus positive patients).
  
  
  CONCLUSIONS
  Although TB incidence is globally decreasing, in our study we found an increasing number of cases in recent years in all subgroups, which can be explained by this being a monographic unit with an intensive contact tracing program.
authors.affiliation: Servicio de Medicina Interna, Hospital Son Llàtzer, Palma, España. Electronic address: jgonzalez4@hsll.es.
authors.forename: Juan
authors.initials: J
authors.lastname: González-Moreno
authors.forename: Mercedes
authors.initials: M
authors.lastname: García-Gasalla
authors.forename: Carmen
authors.initials: C
authors.lastname: Cifuentes Luna
authors.forename: Isabel
authors.initials: I
authors.lastname: Mir Villadrich
authors.forename: Antonio
authors.initials: A
authors.lastname: Pareja Bezares
authors.forename: Verónica
authors.initials: V
authors.lastname: Navarro Fernández
authors.forename: Araceli
authors.initials: A
authors.lastname: Serrano Bujalance
authors.forename: M Cruz
authors.initials: MC
authors.lastname: Pérez Seco
authors.forename: Antonio
authors.initials: A
authors.lastname: Payeras Cifre
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023241:Antiretroviral Therapy, Highly Active; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D048909:Diabetes Complications / Q000453:epidemiology; D004359:Drug Therapy, Combination; D054242:Emigrants and Immigrants / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology; D017052:Hospital Mortality; D006757:Hospital Units / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D009369:Neoplasms / Q000453:epidemiology; D010044:Outpatient Clinics, Hospital / Q000706:statistics & numerical data*; D063728:Secondary Care Centers / Q000706:statistics & numerical data*; D012907:Smoking / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology; D019966:Substance-Related Disorders / Q000453:epidemiology; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents
keywords: Human immunodeficiency virus; Immigration; Inmigración; Tuberculosis; Virus de la inmunodeficiencia humana