title: Hypohidrosis induced by topiramate in an adult patient.
abstract: Hypohidrosis is an uncommon and reversible side effect of topiramate treatment, reported mainly in children. This report presents an adult patient with complex partial seizures who was treated with topiramate and developed hypohidrosis coupled with hyperthermia, related to high environmental temperature and physical exercise. Reduced sweat response was confirmed using the Neuropad test. Signs and symptoms ceased after drug discontinuation. During topiramate treatment, it is important to recognise this side effect, although the exact causal mechanism has not yet been clarified.
authors.affiliation: Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece. stellakarax@gmail.com
authors.forename: Styliani
authors.initials: S
authors.lastname: Karachristianou
authors.forename: Evangelos
authors.initials: E
authors.lastname: Papamichalis
authors.forename: Alexandros
authors.initials: A
authors.lastname: Sarantopoulos
authors.forename: Panagiota
authors.initials: P
authors.lastname: Boura
authors.forename: George
authors.initials: G
authors.lastname: Georgiadis
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005334:Fever / Q000209:etiology; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007007:Hypohidrosis / Q000139:chemically induced* / Q000150:complications; D008297:Male; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose
keywords: adverse effect; hypohidrosis; sweat function; topiramate