title: Neurofibromatosis: chronological history and current issues.
abstract: Neurofibromatosis, which was first described in 1882 by Von Recklinghausen, is a genetic disease characterized by a neuroectodermal abnormality and by clinical manifestations of systemic and progressive involvement which mainly affect the skin, nervous system, bones, eyes and possibly other organs. The disease may manifest in several ways and it can vary from individual to individual. Given the wealth of information about neurofibromatosis, we attempted to present this information in different ways. In the first part of this work, we present a chronological history, which describes the evolution of the disease since the early publications about the disorder until the conclusion of this work, focusing on relevant aspects which can be used by those wishing to investigate this disease. In the second part, we present an update on the various aspects that constitute this disease.
authors.affiliation: Faculdade Estadual de Medicina, São José do Rio Preto (FAMERP), Hospital de Base, Dermatology Service, São José do Rio Preto, SP, Brazil. dr.joao@terra.com.br
authors.forename: João Roberto
authors.initials: JR
authors.lastname: Antônio
authors.forename: Eny Maria
authors.initials: EM
authors.lastname: Goloni-Bertollo
authors.forename: Lívia Arroyo
authors.initials: LA
authors.lastname: Trídico
mesh_terms: D019080:Cafe-au-Lait Spots / Q000473:pathology; D049669:History, 16th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D049691:History, Medieval; D006801:Humans; D017253:Neurofibromatoses / Q000235:genetics / Q000266:history* / Q000473:pathology; D063189:Symptom Assessment