title: Corn oil and milk enhance the absorption of orally administered allyl isothiocyanate in rats.
abstract: Allyl isothiocyanate, a chief component of mustard oil, exhibits anticancer effects in both cultured cancer cells and animal models. The accumulation of the N-acetylcysteine conjugate of allyl isothiocyanate, the final metabolite of allyl isothiocyanate, in urine was evaluated in rats that were orally coadministered allyl isothiocyanate with fluids (e.g., water, green tea, milk, and 10% ethanol) or corn oil. The N-acetylcysteine conjugate of allyl isothiocyanate content in urine when allyl isothiocyanate (2 or 4μmol) was coadministered with corn oil or milk showed a greater increase (1.4±0.22 or 2.7±0.34μmol or 1.2±0.32 or 2.5±0.36μmol, 1.6- to 1.8-fold or 1.5-fold, respectively) than when allyl isothiocyanate (2 or 4μmol) was coadministered with water (0.78±0.10 or 1.7±0.17μmol). This result demonstrates that corn oil and milk enhance the absorption of allyl isothiocyanate in rats.
authors.affiliation: National Institute of Vegetable and Tea Science, National Agriculture and Food Research Organization, 360 Kusawa, Ano, Tsu, Mie 514-2392, Japan. ippoushi@affrc.go.jp
authors.forename: Katsunari
authors.initials: K
authors.lastname: Ippoushi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueda
authors.forename: Atsuko
authors.initials: A
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D003314:Corn Oil / Q000378:metabolism*; D007408:Intestinal Absorption; D017879:Isothiocyanates / Q000378:metabolism* / Q000652:urine; D008297:Male; D008892:Milk / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D017879:Isothiocyanates; D003314:Corn Oil; C004471:allyl isothiocyanate