title: Clinical evaluation of serum cystatin C and creatinine in patients with chronic kidney disease: a meta-analysis.
abstract: OBJECTIVE
  Glomerular filtration rate (GFR) is an important indicator of renal function. This meta-analysis aimed to evaluate the diagnostic value of serum cystatin C (CysC) and serum creatinine (SCr) for estimating GFR in patients with chronic kidney disease.
  
  
  METHODS
  Google Scholar, PubMed®, Cochrane Library and China National Knowledge Infrastructure databases were searched, to identify randomized controlled trials that determined the diagnostic value of CysC and SCr, for estimating GFR in patients with chronic kidney disease.
  
  
  RESULTS
  The inclusion criteria were met by 17 studies (total number of patients with chronic kidney disease, 2521). Meta-analysis showed that when the diagnostic cut-off value of GFR was 80-90 ml/min/1.73 m(2), the heterogeneity was modest for CysC (I(2) = 48%, summary sensitivity [SEN] = 0.803, summary specificity [SPE] = 0.821), but there was no heterogeneity for SCr (I(2) = 0.0%, SEN = 0.697, SPE = 0.787). Meta-analysis of the studies demonstrated a significant difference between patients with chronic kidney disease and controls, for CysC and SCr.
  
  
  CONCLUSIONS
  This meta-analysis demonstrated significant correlations between CysC, SCr and GFR. CysC was more sensitive, but less specific, than SCr for the estimation of GFR.
authors.affiliation: State Key Laboratory of Kidney Diseases, Department of Nephrology, Chinese PLA General Hospital and Military Medical Postgraduate College, Beijing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Xueying
authors.initials: X
authors.lastname: Cao
authors.forename: Guangyan
authors.initials: G
authors.lastname: Cai
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Ribao
authors.initials: R
authors.lastname: Wei
authors.forename: Xueli
authors.initials: X
authors.lastname: Yuan
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Bai
authors.forename: Shuwen
authors.initials: S
authors.lastname: Liu
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Chen
mesh_terms: D003404:Creatinine / Q000097:blood*; D055316:Cystatin C / Q000097:blood*; D016206:Databases, Bibliographic; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D055316:Cystatin C; D003404:Creatinine
keywords: Cystatin C; chronic kidney disease; creatinine; diagnostic value; meta-analysis