title: Adaptation to starvation: translating a matter of life or death.
abstract: There is much interest in defining the nutrient dependencies of cancer cells and their mechanisms of adaptation to nutrient depletion. In a recent issue of Cell, Leprivier and colleagues demonstrate that eEF2K, which can inhibit translation elongation acutely during protein synthesis, is a critical switch in the survival versus death fate of starved cancer cells.
authors.affiliation: Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, SPH2-117, Boston, MA 02115, USA. bmanning@hsph.harvard.edu
authors.forename: Brendan D
authors.initials: BD
authors.lastname: Manning
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D054736:Elongation Factor 2 Kinase / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D010441:Peptide Chain Elongation, Translational; D015398:Signal Transduction
chemical_list: D054736:Elongation Factor 2 Kinase