title: General aspects of drug interactions with systemic antifungals in a retrospective study sample.
abstract: A retrospective study evaluating hepatic laboratory alterations and potential drug interactions in patients treated for onychomycosis. We evaluated 202 patients, 82% female. In 273 liver enzyme tests, there were changes in only 6%. Potential drug interactions were identified in 28% of patients for imidazole and 14% for terbinafine. The risk of potential interactions increased with the patient's age and use of multiple drugs.
authors.affiliation: Dermatology and Radiotheraphy Departament, Faculdade de Medicina de Botucatu, Universidade Estadual de São Paulo, Botucatu, SP, Brazil. julivs@gmail.com
authors.forename: Juliano Vilaverde
authors.initials: JV
authors.lastname: Schmitt
authors.forename: Giovana
authors.initials: G
authors.lastname: Bombonatto
authors.forename: Stella Maris
authors.initials: SM
authors.lastname: Trierweiler
authors.forename: Andrea Buosi
authors.initials: AB
authors.lastname: Fabri
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use*; D014009:Onychomycosis / Q000188:drug therapy*; D012189:Retrospective Studies; D000077291:Terbinafine; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D000077291:Terbinafine