title: Expression of aldehyde dehydrogenase 1 in colon cancer.
abstract: OBJECTIVE
  To study the expression of ALDH1 in colon cancer and its clinical significance.
  
  
  METHODS
  The expression of ALDH1 was examined in 98 surgical specimens of primary colonic carcinoma and 15 normal colon tissues with immunohistochemistry method. The correlations of the expression with clinicopathological parameters and prognosis of colon cancer were analyzed.
  
  
  RESULTS
  The positive rate of expression of ALDH1 was 76.5% (75/98) in the cancer tissues and 13.3% (2/15) in normal colon tissues. There were an obvious statistical difference (P<0.05) between the two groups. The ALDH1 expression was significantly correlated with the histological grade, TNM stages and lymph node metastasis in colon cancer (P<0.05). It was also related with patients' survival time, those with positive expressions had a poor prognosis (P<0.05).
  
  
  CONCLUSIONS
  The results suggeste that the overexpression of ALDH1 plays important roles in proliferation and progression in colon cancer, the ALDH1 may be a valuable marker to predict the biological behavior and trend of metastasis of colon cancer.
authors.affiliation: Department of Surgery, the Second Xiang-ya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hou
authors.forename: Yi-Yi
authors.initials: YY
authors.lastname: Liu
authors.forename: Xiao-Kun
authors.initials: XK
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000080924:Aldehyde Dehydrogenase 1 Family; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000401:mortality; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D050697:Retinal Dehydrogenase / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D007527:Isoenzymes; D000080924:Aldehyde Dehydrogenase 1 Family; C510223:ALDH1A1 protein, human; D050697:Retinal Dehydrogenase