title: Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete.
abstract: Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204, USA.
authors.forename: Kyoung Hwa
authors.initials: KH
authors.lastname: Jang
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Locke
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Kauffman
authors.forename: Deanna S
authors.initials: DS
authors.lastname: Beatty
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Paul
authors.forename: William
authors.initials: W
authors.lastname: Fenical
mesh_terms: D039903:Actinobacteria; D000881:Anthrax / Q000188:drug therapy* / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001408:Bacillus anthracis / Q000187:drug effects*; D019015:Geologic Sediments / Q000737:chemistry / Q000382:microbiology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D061065:Polyketides; D014874:Water Pollutants, Chemical; C583934:anthracimycin
keywords: anthrax; antibiotics; bacillus anthracis; natural products; polyketides