title: Investigation of polymeric excipients for dutasteride solid dispersion and its physicochemical characterization.
abstract: To investigate the effects of polymeric excipients for dutasteride solid dispersion, experimental approaches together with physical interactions at molecular level were evaluated. The drug and various polymers (anionic, amphiphilic, and hydrophilic) were mixed physically into different ratios and their thermodynamic and physical properties were analyzed by differential scanning calorimetry and Fourier transform-infrared spectroscopy, respectively. The enhanced equilibrium solubility of dutasteride was also investigated. Dutasteride is non-ionic and showed low solubility in the tested pH ranges (lower than the detection limit of 20 ng/mL). Kollidon(®) MAE 100P, an anionic polymer, showed enhanced dutasteride solubility in aqueous solution followed by hydrophilic Kollidon(®) SR and the amphiphilic polymer, Soluplus(®). Melting point (T m ) of dutasteride was 249.7 °C and was decreased to 229.84 °C when mixed evenly with Kollidon(®) MAE 100P. However, the melting point was not detected at a ratio of 1:4 since it fully dissolved or dispersed in the polymer. Glass transition temperature (T g ) of different compositions exhibited strong interaction of polymer and drug. The result was supported by spectra evidence that Kollidon(®) MAE 100P forms hydrogen bonds with dutasteride presenting strong physical interaction with the primary amine group of dutasteride. This study supports a convenient method that together with microscopic observation can perform polymer selection and characterize solid dispersions.
authors.affiliation: College of Pharmacy, Dongguk University-Seoul, Donggukro 32, Ilsandonggu, Gyeonggi, Goyang, 410-820, Republic of Korea.
authors.forename: Nam Ah
authors.initials: NA
authors.lastname: Kim
authors.forename: Du Hyung
authors.initials: du H
authors.lastname: Choi
authors.forename: Jun Yeul
authors.initials: JY
authors.lastname: Lim
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Dae Gon
authors.initials: DG
authors.lastname: Lim
authors.forename: Eunhee
authors.initials: E
authors.lastname: Lee
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Park
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Jeong
mesh_terms: D001378:Azasteroids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D000068538:Dutasteride; D005079:Excipients / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008859:Microscopy, Polarization; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D033362:Powder Diffraction; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013817:Thermography
chemical_list: D001378:Azasteroids; D005079:Excipients; D011145:Polyvinyls; C572167:polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; D011092:Polyethylene Glycols; D011205:Povidone; D000068538:Dutasteride