title: A self-organization framework for symmetry breaking in the mammalian embryo.
abstract: The mechanisms underlying the appearance of asymmetry between cells in the early embryo and consequently the specification of distinct cell lineages during mammalian development remain elusive. Recent experimental advances have revealed unexpected dynamics of and new complexity in this process. These findings can be integrated in a new unified framework that regards the early mammalian embryo as a self-organizing system.
authors.affiliation: Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wennekamp
authors.forename: Sven
authors.initials: S
authors.lastname: Mesecke
authors.forename: François
authors.initials: F
authors.lastname: Nédélec
authors.forename: Takashi
authors.initials: T
authors.lastname: Hiiragi
mesh_terms: D000818:Animals; D019521:Body Patterning; D019070:Cell Lineage; D016764:Cell Polarity; D003198:Computer Simulation; D004622:Embryo, Mammalian / Q000166:cytology*; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008954:Models, Biological