title: Chinese medicine formula lingguizhugan decoction improves Beta-oxidation and metabolism of Fatty Acid in high-fat-diet-induced rat model of Fatty liver disease.
abstract: Lingguizhugan decoction (LGZG), a classic traditional Chinese medicine (TCM) formula, has been used to treat obesity and hyperlipidemia in recent years, but the related mechanisms underlying the regulation of lipid metabolism by LGZG are not clear yet. Here, we reported the effectiveness and possible mechanisms of LGZG on rats with fatty liver disease induced by high-fat diet (HFD). Our results demonstrated that LGZG significantly attenuated HFD-induced fatty liver disease, as measured by body weight, liver index, epididymal fat pad-body weight ratio (EFP/BW), liver injury, and hepatic triglycerides (TG) probably through increasing serum thyroid hormone levels, improving beta-oxidation (via modulation of TR β 1 and CPT1A expression), metabolism and transport (through modulation of SREBP-1c, ACSL and ApoB100 expression) of fatty acid. In addition, we discovered the herbal combination with the properties of warming yang to relieve water retention in the formula and proposed the biological basis of LGZG conventional effect via further study on disassembled formula. This study, for the first time, revealed the mechanisms through which LGZG regulates lipid metabolism. Furthermore, our study suggested that it might be feasible to understand the scientific implications of TCM from the perspective of classic formulas' conventional efficacy.
authors.affiliation: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Yang
authors.forename: Lu
authors.initials: L
authors.lastname: Zou
authors.forename: Dong-Fei
authors.initials: DF
authors.lastname: Li
authors.forename: Hong-Zhu
authors.initials: HZ
authors.lastname: Wen
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Zheng
authors.forename: Lian-Jun
authors.initials: LJ
authors.lastname: Xing
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Song
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Tang
authors.forename: Guang
authors.initials: G
authors.lastname: Ji