title: Pharmacists promote rational use of antibiotic prophylaxis in Type I incision operations via application of drug use evaluation.
abstract: OBJECTIVE
  Drug use evaluation (DUE) criteria were established to assess the rational use of antibiotic prophylaxis (RUAP) in Type I incision operations (TOIO) during peri-operation period and to enhance pharmacists' responsibilities for antibiotic stewardship.
  
  
  METHODS
  The criteria were set with a threshold based on a literature review and discussions with multidisciplinary experts. Patients who received TOIO from July 2008 to June 2012 were enrolled in the study. The percentage of prescriptions adhering to all items of criteria was 10% at baseline.
  
  
  RESULTS
  According to DUEs and interviews by pharmacists, the percentages of prescriptions adhering to all items of criteria of DUE-1, DUE-3, DUE-5, and DUE-8 were 13.3, 20.0, 50.0 and 66.7%, respectively. The study showed that the most common inappropriate therapies were no indications for prophylaxis antibiotic use and inappropriate choices of antibiotics. Pharmacists finally disseminated DUE criteria and reports to prescribe and improve RUAP in TOIO at the hospital through the Drug and Therapeutics Committee (DTC).
  
  
  CONCLUSIONS
  The study demonstrated that application of pharmacist- directed DUE is a useful strategy to detect, supervise and help correct challenges encountered during antibiotic prophylaxis in TOIO.
authors.forename: Qing-ping
authors.initials: QP
authors.lastname: Shi
authors.forename: Feng
authors.initials: F
authors.lastname: Ding
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Ran
authors.initials: R
authors.lastname: Sang
authors.forename: Jin-xiu
authors.initials: JX
authors.lastname: Zhu
authors.forename: Pei-lan
authors.initials: PL
authors.lastname: Shi
authors.forename: Mu-hua
authors.initials: MH
authors.lastname: Wang
authors.forename: Hao-yu
authors.initials: HY
authors.lastname: Yuan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019072:Antibiotic Prophylaxis; D003430:Cross-Sectional Studies; D017723:Drug Utilization Review; D005260:Female; D006801:Humans; D057970:Inappropriate Prescribing; D008297:Male; D008875:Middle Aged; D010595:Pharmacists; D012189:Retrospective Studies