title: Analytical techniques for the determination of biologically active quinones in biological and environmental samples.
abstract: Quinones are compounds that have various characteristics such as biological electron transporter, therapeutic agent and harmful environmental pollutant. Therefore, an effective analytical method for quinones is useful in many fields including biomedical, clinical and toxicological studies. This review describes the principle and feature of analytical techniques for quinones including high-performance liquid chromatography with ultraviolet, fluorescence, chemiluminescence, electrochemical detection and mass spectrometry, gas chromatography with mass spectrometry and capillary electrophoresis. Furthermore, the sensitivity and the sample preparation method for the determination of several quinones such as vitamin K, ubiquinone, doxorubicin and polycyclic aromatic hydrocarbon quinone in biological and environmental samples are summarized.
authors.affiliation: Graduate School of Biomedical Sciences, Course of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. Electronic address: kishika@nagasaki-u.ac.jp.
authors.forename: Naoya
authors.initials: N
authors.lastname: Kishikawa
authors.forename: Naotaka
authors.initials: N
authors.lastname: Kuroda
mesh_terms: D000818:Animals; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis / Q000737:chemistry; D006801:Humans; D011809:Quinones / Q000032:analysis* / Q000737:chemistry; D014116:Toxicology / Q000379:methods
chemical_list: D004785:Environmental Pollutants; D011809:Quinones
keywords: Chromatography; Doxorubicin; Polycyclic aromatic hydrocarbon quinone; Quinone; Ubiquinone; Vitamin K