title: High-frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation plus pressure support in preterm infants with severe respiratory distress syndrome.
abstract: BACKGROUND
  Mechanical ventilation and surfactants are the standard treatment of preterm respiratory distress syndrome (RDS). The effects of the primary ventilation model on bronchopulmonary dysplasia (BPD) and long-term neurodevelopment outcomes are controversial. The purpose of this study was to compare the efficacy and safety of high-frequency oscillatory ventilation (HFOV) and synchronized intermittent mandatory ventilation plus pressure support ventilation (SIMV-PSV) in preterm infants with severe RDS.
  
  
  METHODS
  A total of 366 eligible preterm infants were randomly assigned to treatment with HFOV (n = 184) or SIMV-PSV (n = 182). Surfactant was applied if PaO2/FIO2 was < 200 mm Hg after 2 hours of ventilation. Primary outcomes were mortality or incidence of BPD. Secondary outcomes were duration of ventilation and hospitalization, surfactant requirements, pneumothorax, retinopathy of prematurity ≥ stage 2, and neurodevelopment at 18 months of corrected age.
  
  
  RESULTS
  Survival and complete outcome data were available for 288 infants at 18 months of corrected age. The incidence of death or BPD was significantly higher in the SIMV-PSV group (P = .001). The duration of mechanical ventilation and hospitalization was shorter and the incidence of surfactant requirement and retinopathy of prematurity was lower in the HFOV group (P < .001, P = .002, P = .04, respectively). Moderate or severe neurological disability was less frequent in the HFOV group than in the SIMV-PSV group at 18 months (P = .03). The combination of HFOV and surfactant dramatically reduced negative outcomes in preterm infants with severe RDS.
  
  
  CONCLUSIONS
  Initial ventilation with HFOV in preterm infants with severe RDS reduces the incidence of death and BPD, and improves long-term neurodevelopment outcomes. (ClinicalTrials.gov NCT01496508).
authors.affiliation: Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Huiqing
authors.initials: H
authors.lastname: Sun
authors.forename: Rui
authors.initials: R
authors.lastname: Cheng
authors.forename: Wengqing
authors.initials: W
authors.lastname: Kang
authors.forename: Hong
authors.initials: H
authors.lastname: Xiong
authors.forename: Chongchen
authors.initials: C
authors.lastname: Zhou
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Wang
authors.forename: Changlian
authors.initials: C
authors.lastname: Zhu
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000209:etiology / Q000517:prevention & control; D005260:Female; D005865:Gestational Age; D006612:High-Frequency Ventilation; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D017063:Outcome Assessment, Health Care; D061214:Patient Safety; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications / Q000401:mortality / Q000628:therapy*
keywords: high-frequency oscillatory ventilation; neurodevelopment; preterm infants; respiratory distress syndrome