title: My brain told me to do it.
abstract: Voluntary motor control requires circuits in the brain to develop synchronously with spinal motor circuitry. In this issue of Developmental Cell,Reimer et al. (2013) demonstrate that this process is coordinated in zebrafish: dopamine released from descending projections modulates formation of motor neurons by attenuating the response of progenitors to Shh signaling.
authors.affiliation: Department of Neurobiology, David Geffen School of Medicine at UCLA, 610 Charles Young Drive East, Los Angeles, CA 90095, USA.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Kong
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Butler
authors.forename: Bennett G
authors.initials: BG
authors.lastname: Novitch
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D009046:Motor Neurons / Q000166:cytology*; D012038:Regeneration
chemical_list: D004298:Dopamine