title: The myeloid response to pancreatic carcinogenesis is regulated by the receptor for advanced glycation end-products.
abstract: We identified a critical role for receptor for advanced glycation end products (RAGE) in the intratumoral accumulation of myeloid-derived suppressor cells (MDSCs) during pancreatic carcinogenesis. The absence of RAGE markedly delayed neoplasia and limited MDSC accumulation in mice expressing an oncogenic variant ofKras. In spite of MDSCs, these mice accumulated non-immunosuppressive macrophages. Thus, RAGE regulates carcinogenesis and consequent myeloid responses.
authors.affiliation: Department of Surgery; Hillman Cancer Center; University of Pittsburgh Cancer Institute; Pittsburgh, PA USA.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Vernon
authors.forename: Herbert J
authors.initials: HJ
authors.lastname: Zeh Iii
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lotze
keywords: DAMPs; MDSCs; RAGE; pancreatic carcinogenesis