title: Serum uric acid is more strongly associated with impaired fasting glucose in women than in men from a community-dwelling population.
abstract: Serum uric acid (SUA) levels are associated with metabolic syndrome (MetS) and its components such as glucose intolerance and type 2 diabetes. It is unknown whether there are gender-specific differences regarding the relationship between SUA levels, impaired fasting glucose (IFG) and newly detected diabetes. We recruited 1,209 men aged 60±15 (range, 19-89) years and 1,636 women aged 63±12 (range, 19-89) years during their annual health examination from a single community. We investigated the association between SUA levels and six categories according to fasting plasma glucose (FPG) level {normal fasting glucose (NFG), <100 mg/dL; high NFG-WHO, 100 to 109 mg/dL; IFG-WHO, 110 to 125 mg/dL; IFG-ADA, 100 to 125 mg/dL; newly detected diabetes, ≥126 mg/dL; known diabetes} SUA levels were more strongly associated with the different FPG categories in women compared with men. In women, the associations remained significant for IFG-WHO (OR, 1.23, 95% CI, 1.00-1.50) and newly detected diabetes (OR, 1.33, 95% CI, 1.03-1.72) following multivariate adjustment. However, in men all the associations were not significant. Thus, there was a significant interaction between gender and SUA level for newly detected diabetes (P = 0.005). SUA levels are associated with different categories of impaired fasting glucose in participants from community-dwelling persons, particularly in women.
authors.affiliation: Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. rykawamo@m.ehime-u.ac.jp
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawamoto
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
authors.forename: Tomo
authors.initials: T
authors.lastname: Kusunoki
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D005215:Fasting / Q000097:blood*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014527:Uric Acid