title: Mean platelet volume is decreased during an acute exacerbation of chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  An increased mean platelet volume (MPV) is an early marker of platelet activation. Activated platelets play a role in atherogenesis, inflammation and atherothrombosis. Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular disease-related mortality. The aim of the study is to measure the MPV in patients with stable and exacerbated COPD.
  
  
  METHODS
  We investigated the peripheral blood cell count parameters, C-reactive protein (CRP), fibrinogen, lung function parameters and arterial blood gas analysis in patients with COPD and in controls. Seventy participants were investigated at admission for an acute exacerbation of COPD and reassessed when stable. Seventy controls were matched for age, gender, body mass index, medication use and smoking.
  
  
  RESULTS
  Participants with an exacerbation of COPD had lower MPV and higher CRP, white blood cells (WBC) and fibrinogen compared with when in stable phase of COPD and controls. MPV was also lower in patients in stable phase COPD compared with controls. Negative correlations between MPV and CRP, and between MPV and platelet count were present in patients in stable and exacerbation of COPD.
  
  
  CONCLUSIONS
  The findings show that COPD patients, during acute exacerbation and in stable phase, have lower MPV compared with healthy controls; the MPV increase once patients have recovered from their exacerbation of COPD.
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Rui-tao
authors.initials: RT
authors.lastname: Wang
authors.forename: Jia-Ying
authors.initials: JY
authors.lastname: Li
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Cao
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
mesh_terms: D000368:Aged; D001772:Blood Cell Count; D001784:Blood Gas Analysis; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D005340:Fibrinogen; D002097:C-Reactive Protein
keywords: C-reactive protein; chronic obstructive pulmonary disease; mean platelet volume; platelet activation; systemic inflammation