title: Spanish Menopause Society position statement: use of tibolone in postmenopausal women.
abstract: Tibolone is a drug with complex tissue-specific action that exhibits a combination of estrogenic, progestogenic, and slight androgenic activity. Its variable profile explains its clinical effects, depending on the target tissue where it is metabolized, its metabolites' affinity for and potency in hormone receptors, and probable enzymatic activity modulation.In recent reviews and clinical trials, the effectiveness of tibolone in alleviating different hot flush menopause symptoms, mainly in mood and sexuality disorders, has been noted. In Spain, tibolone is the most prescribed hormonal treatment, and one of the most common complaints among postmenopausal women is change in sexual drive. For such reason, a panel of experts from the Spanish Menopause Society met to develop usage recommendations based on the best evidence available.
authors.affiliation: Department of Obstetrics and Gynecology, University of Granada, Granada, Spain. nicomendoza@telefonica.net
authors.forename: Nicolás
authors.initials: N
authors.lastname: Mendoza
authors.forename: Pedro
authors.initials: P
authors.lastname: Abad
authors.forename: Francesc
authors.initials: F
authors.lastname: Baró
authors.forename: Ma Jesús
authors.initials: MJ
authors.lastname: Cancelo
authors.forename: Plácido
authors.initials: P
authors.lastname: Llaneza
authors.forename: Montserrat
authors.initials: M
authors.lastname: Manubens
authors.forename: Francisco
authors.initials: F
authors.lastname: Quereda
authors.forename: Rafael
authors.initials: R
authors.lastname: Sánchez-Borrego
mesh_terms: D000368:Aged; D015519:Bone Density / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000517:prevention & control; D015914:Estrogen Replacement Therapy; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D009652:Norpregnenes / Q000009:adverse effects / Q000627:therapeutic use*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000517:prevention & control; D017698:Postmenopause; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy; D012955:Societies, Medical; D013030:Spain
chemical_list: D009652:Norpregnenes; C027385:tibolone