title: Sociodemographic correlates of allostatic load among a national sample of adolescents: findings from the National Health and Nutrition Examination Survey, 1999-2008.
abstract: OBJECTIVE
  There is growing evidence that racial, ethnic, and socioeconomic status (SES) differentials in health emerge early in life. This study provided a descriptive profile of allostatic load (AL) among adolescents, focusing on sociodemographic correlates and variation in age patterns of AL by race and ethnicity. Allostatic load, an index of cumulative physiological dysregulation, is a construct that measures how individuals' interactions with their environment "get under the skin" to influence health.
  
  
  METHODS
  We used data from 8,052 adolescents ages 12-19 years, from the United States National Health and Nutrition Examination Survey 1999-2008. A summary measure of AL was assessed with biomarkers representing cardiovascular, inflammatory, and metabolic systems. Weighted univariate, bivariate, and multivariable negative binomial regression statistics were employed.
  
  
  RESULTS
  Mean AL increased with age, was higher for blacks than whites or Mexican-Americans, and was higher among adolescents of lower SES. Although black adolescents had higher AL for all ages, the relative advantage of whites and Mexican-Americans declined with age.
  
  
  CONCLUSIONS
  Racial and SES inequalities in AL exist during adolescence. These findings contribute to the understanding of how early life adverse factors "get under the skin," and are potentially translated into disease outcomes and health disparities later in life.
authors.affiliation: Department of Health Sciences, California State University-Northridge, Northridge, California. Electronic address: Bethany.Rainisch@csun.edu.
authors.forename: Bethany K Wexler
authors.initials: BK
authors.lastname: Rainisch
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Upchurch
mesh_terms: D000293:Adolescent; D052636:Allostasis / Q000502:physiology*; D015415:Biomarkers / Q000032:analysis*; D002648:Child; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D008297:Male; D009749:Nutrition Surveys; D012044:Regression Analysis; D012923:Social Class; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Adolescent health; Allostatic load; Biological markers; Racial and ethnic health disparities