title: Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.
abstract: During the mitotic division cycle, cells pass through an extensive microtubule rearrangement process where microtubules forming the mitotic spindle apparatus are dynamically instable. Several centrosomal- and microtubule-associated proteins are involved in the regulation of microtubule dynamics and stability during mitosis. Here, we focus on members of the transforming acidic coiled coil (TACC) family of centrosomal adaptor proteins, in particular TACC3, in which their subcellular localization at the mitotic spindle apparatus is controlled by Aurora-A kinase-mediated phosphorylation. At the effector level, several TACC-binding partners have been identified and characterized in greater detail, in particular, the microtubule polymerase XMAP215/ch-TOG/CKAP5 and clathrin heavy chain (CHC). We summarize the recent progress in the molecular understanding of these TACC3 protein complexes, which are crucial for proper mitotic spindle assembly and dynamics to prevent faulty cell division and aneuploidy. In this regard, the (patho)biological role of TACC3 in development and cancer will be discussed.
authors.forename: Harish C
authors.initials: HC
authors.lastname: Thakur
authors.forename: Madhurendra
authors.initials: M
authors.lastname: Singh
authors.forename: Luitgard
authors.initials: L
authors.lastname: Nagel-Steger
authors.forename: Daniel
authors.initials: D
authors.lastname: Prumbaum
authors.forename: Eyad Kalawy
authors.initials: EK
authors.lastname: Fansa
authors.forename: Lothar
authors.initials: L
authors.lastname: Gremer
authors.forename: Hakima
authors.initials: H
authors.lastname: Ezzahoini
authors.forename: André
authors.initials: A
authors.lastname: Abts
authors.forename: Lutz
authors.initials: L
authors.lastname: Schmitt
authors.forename: Stefan
authors.initials: S
authors.lastname: Raunser
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Ahmadian
authors.forename: Roland P
authors.initials: RP
authors.lastname: Piekorz
mesh_terms: D033963:Adaptor Protein Complex 3 / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D000818:Animals; D002455:Cell Division / Q000235:genetics; D018385:Centrosome / Q000737:chemistry* / Q000473:pathology / Q000502:physiology; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D008938:Mitosis / Q000235:genetics; D005810:Multigene Family / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D008941:Spindle Apparatus / Q000235:genetics
chemical_list: D033963:Adaptor Protein Complex 3; D008869:Microtubule-Associated Proteins; C120551:TACC3 protein, human