title: Protection of dietary polyphenols against oral cancer.
abstract: Oral cancer represents a health burden worldwide with approximate 275,000 new cases diagnosed annually. Its poor prognosis is due to local tumor invasion and frequent lymph node metastasis. Better understanding and development of novel treatments and chemo-preventive approaches for the preventive and therapeutic intervention of this type of cancer are necessary. Recent development of dietary polyphenols as cancer preventives and therapeutic agents is of great interest due to their antioxidant and anti-carcinogenic activities. Polyphenols may inhibit carcinogenesis in the stage of initiation, promotion, or progression. In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by induction of cell death and inhibition of tumor growth, invasion, and metastasis. In this review, we discuss current progress of dietary polyphenols against oral cancers in vitro, in vivo, and at population levels.
authors.affiliation: Department of Stomatology, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China. hzdyj@yahoo.com.cn
authors.forename: Yijian
authors.initials: Y
authors.lastname: Ding
authors.forename: Hua
authors.initials: H
authors.lastname: Yao
authors.forename: Yanan
authors.initials: Y
authors.lastname: Yao
authors.forename: Leonard Yenwong
authors.initials: LY
authors.lastname: Fai
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage*; D001682:Biological Availability; D018890:Chemoprevention; D004032:Diet; D004610:Ellagic Acid / Q000008:administration & dosage; D005419:Flavonoids / Q000008:administration & dosage; D006801:Humans; D009062:Mouth Neoplasms / Q000517:prevention & control*; D008517:Phytotherapy; D059808:Polyphenols / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage; D013662:Tea / Q000737:chemistry
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D005419:Flavonoids; D059808:Polyphenols; D013267:Stilbenes; D013662:Tea; D004610:Ellagic Acid; D000077185:Resveratrol