title: Ayurvedic formulations ameliorate cisplatin-induced nephrotoxicity: preclinical studies on Brahma Rasayana and Chyavanaprash.
abstract: OBJECTIVE
  To explore the ability of two Ayurvedic formulations, Brahma Rasayana (BRM) and Chyavanaprash (CHM) in alleviating Cisplatin (Cis-dichlorodiammineplatinum [II] CDDP) induced acute nephrotoxicity.
  
  
  METHODS
  Swiss albino mice were administered with CDDP (12 mg/kg, i.p) and two doses of BRM or CHM (1 and 2 g/kg). Various antioxidant parameters in the kidney as well as release of marker enzymes in the serum were assayed. Histology of the kidney was also performed to check for CDDP induced damages.
  
  
  RESULTS
  Administration of either BRM or CHM (1 and 2 g/kg) maintained the antioxidant status in the kidney thereby preventing tissue damage as well as the release of marker enzymes. CDDP induced variation of renal architecture was also prevented by BRM and CHM administration.
  
  
  CONCLUSIONS
  BRM and CHM administration could prevent CDDP induced acute renal toxicity.
authors.affiliation: Deptartment of Radiation Biology, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India.
authors.forename: Aditya
authors.initials: A
authors.lastname: Menon
authors.forename: Cherupally Krishnan
authors.initials: CK
authors.lastname: Krishnan Nair
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D002945:Cisplatin / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D028321:Plant Preparations / Q000494:pharmacology*; D011897:Random Allocation
chemical_list: D000975:Antioxidants; C518324:Chyavanprash; D010936:Plant Extracts; D028321:Plant Preparations; C403274:brahma rasayana; D002945:Cisplatin