title: Cardiolipin-mediated cellular signaling.
abstract: This review focuses on recent studies showing that cardiolipin (CL), a unique mitochondrial phospholipid, regulates many cellular functions and signaling pathways, both inside and outside the mitochondria. Inside the mitochondria, CL is a critical target of mitochondrial generated reactive oxygen species (ROS) and regulates signaling events related to apoptosis and aging. CL deficiency causes perturbation of signaling pathways outside the mitochondria, including the PKC-Slt2 cell integrity pathway and the high osmolarity glycerol (HOG) pathway, and is a key player in the cross-talk between the mitochondria and the vacuole. Understanding these connections may shed light on the pathology of Barth syndrome, a disorder of CL remodeling.
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
authors.forename: Vinay A
authors.initials: VA
authors.lastname: Patil
authors.forename: Miriam L
authors.initials: ML
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D017209:Apoptosis; D001692:Biological Transport; D002308:Cardiolipins / Q000502:physiology*; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014617:Vacuoles / Q000502:physiology
chemical_list: D002308:Cardiolipins; D017382:Reactive Oxygen Species