title: [Combination of narrow-band imaging and autofluorescence imaging videobronchoscopy in the assessment of lung cancer].
abstract: BACKGROUND
  Narrow-band imaging (NBI) and autofluorescence imaging (AFI) are new bronchoscopy technologies that are important in lung cancer diagnosis. The aim of this study is to determine whether or not the combination of these two technologies can improve sensitivity and specificity of lung cancer diagnosis.
  
  
  METHODS
  A total of 137 patients who manifested symptoms of lung cancer were investigated in this project. All of the examinations were performed based on an Olympus Evis Lucera bronchoscopy system. The patients were examined by white light bronchoscopy (WLB), NBI and AFI. At least three biopsies from body parts visualized as lesions were obtained from each patient.
  
  
  RESULTS
  WLB sensitivity and specificity were 56.6% and 62.5%, respectively. NBI sensitivity and specificity were 71.3% and 75.0%, respectively. AFI sensitivity and specificity were 82.2% and 25.0%, respectively. The sensitivity and the specificity of the combined NBI and AFI were 94.6% and 87.5%, respectively. The sensitivity and the specificity of the combined NBI and AFI were significantly higher than those of AFI alone (P<0.01). Likewise, the sensitivity and the specificity of the combined NBI and AFI were significantly higher than those of NBI alone (P<0.05).
  
  
  CONCLUSIONS
  NBI or AFI exhibited higher sensitivity of lung cancer diagnosis than WLB. Combined NBI and AFI also showed significantly higher sensitivity and specificity than NBI or AFI.
authors.affiliation: Department of Respiratory Diseases, Affiliated Hospital of Ningbo University Medical College, Ningbo 315020, China.
authors.forename: Zhongbo
authors.initials: Z
authors.lastname: Chen
authors.forename: Yiming
authors.initials: Y
authors.lastname: Yu
authors.forename: Shifang
authors.initials: S
authors.lastname: Sun
authors.forename: Hongying
authors.initials: H
authors.lastname: Ma
authors.forename: Qiaoli
authors.initials: Q
authors.lastname: Zhang
authors.forename: Dan
authors.initials: D
authors.lastname: Lv
authors.forename: Bijiong
authors.initials: B
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Cao
authors.forename: Qunli
authors.initials: Q
authors.lastname: Ding
authors.forename: Zaichun
authors.initials: Z
authors.lastname: Deng
mesh_terms: D000368:Aged; D001999:Bronchoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D061848:Optical Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity