title: Subthalamic nucleus deep brain stimulation: an invaluable role for MER.
abstract: BACKGROUND
  Subthalamic nucleus (STN) deep brain stimulation (DBS) is currently the main surgical procedure for medically refractory Parkinson's disease. The benefit of intra-operative microelectrode recording (MER) for the purpose of neurophysiological localization and mapping of the STN continues to be debated.
  
  
  METHODS
  A retrospective review of the charts and operative reports of all patients receiving STN DBS implantation for Parkinson's disease at our institution from January 2004 to March 2011 was done.
  
  
  RESULTS
  Data from 43 of 44 patients with Parkinson's disease treated with STN DBS were reviewed. The average number of tracts on the left was 2.4, versus 2.3 on the right. The average dorsal and ventral anatomical boundaries of the STN based on Schaltenbrand's Stereotactic Atlas were estimated to be at -5.0 mm above and +1.4 mm below target respectively. The average dorsal and ventral boundaries of the STN using MER were -2.6 mm above and +2.0 mm below target respectively. The average dorsal-ventral distance of the STN as predicted by Stereotactic Atlas was 6.4 mm, compared to 4.6 mm as determined by MER. MER demonstrated the average dorsal and ventral boundaries on the left side were -2.6 mm and +2.2 mm from target respectively, while the average dorsal and ventral boundaries on the right side were -2.5 mm and +1.8 mm from target respectively with MER.
  
  
  CONCLUSIONS
  MER in STN DBS surgery demonstrated measurable difference between stereotactic atlas/MRI STN target and neurophysiologic STN localization.
authors.affiliation: Department of Surgery, Section of Neurosurgery, University of Manitoba, Winnipeg, Manitoba, Canada. umzeitler@cc.umanitoba.ca
authors.forename: F A
authors.initials: FA
authors.lastname: Zeiler
authors.forename: M
authors.initials: M
authors.lastname: Wilkinson
authors.forename: J P
authors.initials: JP
authors.lastname: Krcek
mesh_terms: D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods*; D004567:Electrodes, Implanted; D006801:Humans; D008839:Microelectrodes; D010300:Parkinson Disease / Q000628:therapy*; D012189:Retrospective Studies; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000502:physiology*