title: Converging paths to progress for skull base chordoma: Review of current therapy and future molecular targets.
abstract: BACKGROUND
  Chordomas of the skull base are rare locally aggressive neoplasms with a predilection for encapsulating critical neurovascular structures, bony destruction and irregular growth patterns, and from which patients succumb to recurrence and treatment failures.
  
  
  METHODS
  A review of the medical literature is performed, using standard search engines and identifying articles related to skull base chordomas, surgery, radiation therapy, chemotherapy, molecular genetics, and prospective trials.
  
  
  RESULTS
  A synthesis of the literature is presented, including sections on pathology, treatment, molecular genetics, challenges, and future directions.
  
  
  CONCLUSIONS
  Beyond an understanding of the current treatment paradigms for skull base chordomas, the reader gains insight into the collaborative approach applied to orphan diseases, of which chordomas is a prime exemplar.
authors.affiliation: Division of Neurosurgery, McGill University, Jewish General Hospital, Montreal, QC, Canada.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Di Maio
authors.forename: Esther
authors.initials: E
authors.lastname: Kong
authors.forename: Stephen
authors.initials: S
authors.lastname: Yip
authors.forename: Robert
authors.initials: R
authors.lastname: Rostomily
keywords: Chordomas; cell lines; radiation therapy; review; skull base neoplasms; surgery