title: [Multiple familial "eruptive" dermatofibromas].
abstract: BACKGROUND
  Multiple eruptive dermatofibromas (DF) are rare and frequently associated with immune and neoplastic diseases. There have also been reports of rare familial cases. Herein we report a new such case.
  
  
  METHODS
  A 79-year-old woman and her 37-year-old daughter were seen for disseminated DF over a period of several decades, from adolescence onwards. Neither had any history of diseases or treatments normally associated with multiple DF. History-taking revealed similar lesions in other family members.
  
  
  CONCLUSIONS
  DF are common benign cutaneous tumours, generally seen on the lower limbs of young or middle-aged women. These lesions occur either in isolation or are relatively few. Multiple or so-called eruptive DF, defined by the presence of more than 15 lesions in a single patient, is rare and is associated in 60% of cases with autoimmune diseases, HIV infection, neoplastic disease or immunosuppressant therapy. Familial forms such as those described herein are extremely rare.
authors.affiliation: Service de dermatologie, université Montpellier 1, hôpital Saint-Éloi, CHU, 80, avenue Auguste-Fliche, 34295 Montpellier, France. myriammarque@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Marque
authors.forename: V
authors.initials: V
authors.lastname: Pallure
authors.forename: P
authors.initials: P
authors.lastname: Huet
authors.forename: D
authors.initials: D
authors.lastname: Bessis
authors.forename: B
authors.initials: B
authors.lastname: Guillot
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics; D007121:Immunocompetence; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*