title: Light-regulated stapled peptides to inhibit protein-protein interactions involved in clathrin-mediated endocytosis.
abstract: Control of membrane traffic: Photoswitchable inhibitors of protein-protein interactions were applied to photoregulate clathrin-mediated endocytosis (CME) in living cells. Traffic light (TL) peptides acting as "stop" and "go" signals for membrane traffic can be used to dissect the role of CME in receptor internalization and in cell growth, division, and differentiation.
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), C/Baldiri Reixac 10, 08028 Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Nevola
authors.forename: Andrés
authors.initials: A
authors.lastname: Martín-Quirós
authors.forename: Kay
authors.initials: K
authors.lastname: Eckelt
authors.forename: Núria
authors.initials: N
authors.lastname: Camarero
authors.forename: Sébastien
authors.initials: S
authors.lastname: Tosi
authors.forename: Artur
authors.initials: A
authors.lastname: Llobet
authors.forename: Ernest
authors.initials: E
authors.lastname: Giralt
authors.forename: Pau
authors.initials: P
authors.lastname: Gorostiza
mesh_terms: D002966:Clathrin / Q000494:pharmacology*; D004705:Endocytosis / Q000187:drug effects / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D008027:Light; D010446:Peptide Fragments / Q000378:metabolism*; D060066:Protein Interaction Maps / Q000187:drug effects*; D021381:Protein Transport; D014168:Transferrin / Q000378:metabolism
chemical_list: D002966:Clathrin; D010446:Peptide Fragments; D014168:Transferrin
keywords: clathrin-mediated endocytosis; optopharmacology; peptides; photoswitches; protein-protein interactions