title: Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application.
abstract: A fully automatized radiosynthesis of (+)- and (-)-[(18)F]Flubatine ((+)- and (-)NCFHEB) by means of a commercially available synthesis module (TRACERlab FX FN) under GMP conditions is reported. Radiochemical yields of 30% within an overall synthesis time of 40 min were achieved in more than 70 individual syntheses. Specific activities were approximately 3000 GBq/μmol and radiochemical purity was determined to be at least 97%.
authors.affiliation: Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, D-04103 Leipzig, Germany. marianne.patt@uniklinik-leipzig.de
authors.forename: Marianne
authors.initials: M
authors.lastname: Patt
authors.forename: Andreas
authors.initials: A
authors.lastname: Schildan
authors.forename: Bernd
authors.initials: B
authors.lastname: Habermann
authors.forename: Steffen
authors.initials: S
authors.lastname: Fischer
authors.forename: Achim
authors.initials: A
authors.lastname: Hiller
authors.forename: Winnie
authors.initials: W
authors.lastname: Deuther-Conrad
authors.forename: Stephan
authors.initials: S
authors.lastname: Wilke
authors.forename: René
authors.initials: R
authors.lastname: Smits
authors.forename: Alexander
authors.initials: A
authors.lastname: Hoepping
authors.forename: Gudrun
authors.initials: G
authors.lastname: Wagenknecht
authors.forename: Jörg
authors.initials: J
authors.lastname: Steinbach
authors.forename: Peter
authors.initials: P
authors.lastname: Brust
authors.forename: Osama
authors.initials: O
authors.lastname: Sabri
mesh_terms: D001331:Automation; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D011786:Quality Control; D013237:Stereoisomerism
chemical_list: D001549:Benzamides; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005462:Fluorine Radioisotopes; C115362:fluoronorchloroepibatidine
keywords: Automation; Flubatine; Fluorine-18; GMP; NCFHEB; α(4)β(2) Nicotinic acetylcholine receptors