title: A patient presenting with bilateral lung lesions, pleural effusion, and proteinuria.
abstract: Diagnosis and management of a systemic vasculitis are among the most demanding challenges in clinical medicine. A patient with a past history of cryptogenic organizing pneumonia presents with new bilateral lung lesions, unilateral pleural effusion, and significant proteinuria. The patient tested p-ANCA and anti-MPO positive but c-ANCA negative. A diagnosis of granulomatosis with polyangiitis GPA was reached after performing both renal and lung biopsies. Step-by-step differential diagnosis and management are discussed.
authors.affiliation: Department of Thoracic Medicine, University of Crete, Medical School, 71110 Heraklion, Crete, Greece.
authors.forename: Katerina D
authors.initials: KD
authors.lastname: Samara
authors.forename: Giorgos
authors.initials: G
authors.lastname: Papadogiannis
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Nicholson
authors.forename: Eleutherios
authors.initials: E
authors.lastname: Magkanas
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Stylianou
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Siafakas
authors.forename: Katerina M
authors.initials: KM
authors.lastname: Antoniou