title: Adrenal hypofunction from histoplasmosis: a literature review from 1971 to 2012.
abstract: OBJECTIVE
  While histoplasmosis has been reported from most continents, the disease is most often recognized in the midwestern United States. The recent diagnosis of adrenal hypofunction in two patients with progressive disseminated histoplasmosis (PDH) in our hospital led us to review the literature.
  
  
  METHODS
  We reviewed PubMed using the search term "adrenal histoplasmosis" for the years 1971 to 2012.
  
  
  RESULTS
  The results included 242 patients with adrenal histoplasmosis from either case reports or case series. Most of the reported patients were from countries not previously considered to be heavily endemic for histoplasmosis. In addition, 41.3 % of patients with adrenal involvement developed adrenal hypofunction.
  
  
  CONCLUSIONS
  As modern technology elucidates more cases of adrenal histoplasmosis, the global boundaries of endemicity are being redefined.
authors.affiliation: Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. koene030@umn.edu
authors.forename: R J
authors.initials: RJ
authors.lastname: Koene
authors.forename: J
authors.initials: J
authors.lastname: Catanese
authors.forename: G A
authors.initials: GA
authors.lastname: Sarosi
mesh_terms: D000309:Adrenal Insufficiency / Q000453:epidemiology*; D019353:Endemic Diseases; D014943:Global Health; D006660:Histoplasmosis / Q000150:complications*; D006801:Humans