title: Association of two SNPs in the coding region of the insulin-like growth factor 1 receptor (IGF1R) gene with growth-related traits in Angus cattle.
abstract: The insulin-like growth factor 1 (IGF-1) is considered to be a factor that mainly regulates growth, differentiation, and the maintenance of various function in numerous tissues through binding to a family of transmembrane tyrosine kinase receptors, signaling primarily through the insulin-like growth factor 1 receptor (IGF-1R) encoded by the IGF1R gene. The objectives of the present study were to estimate the allele and genotype frequencies of the IGF1R/MspI (silent mutation within exon 12) and the IGF1R/TaqI (within the 3' untranslated region, 3'UTR) gene polymorphisms in beef cattle and to determine associations between these polymorphisms and growth traits. In a preliminary study on 310 Angus calves, association analyses with three production traits (birth weight, BWT; weaning weight adjusted to 210 days, WWT210; and average daily gain, ADG) were conducted. The GG genotype of the IGF1R/e12/MspI polymorphism was significantly associated (P ≤ 0.05) with a higher WWT210 (+5.06 kg) compared to the AG genotype. Polymorphism within the 3'UTR had no significant effect on growth traits. The effect of combined genotypes was also examined. At WWT(210), calves with the GG/AA and GG/AG combinations were heavier than calves with the AG/AA and AG/AG combined genotypes (P ≤ 0.05). To our knowledge, this is the first report of a polymorphism within the coding region of the Bos taurus IGF1R gene.
authors.affiliation: Laboratory of Molecular Cytogenetics, Department of Ruminant Science, The West Pomeranian University of Technology, Judyma 10, 71-460, Szczecin, Poland. malgorzata.szewczuk@zut.edu.pl
authors.forename: M
authors.initials: M
authors.lastname: Szewczuk
authors.forename: S
authors.initials: S
authors.lastname: Zych
authors.forename: J
authors.initials: J
authors.lastname: Wójcik
authors.forename: E
authors.initials: E
authors.lastname: Czerniawska-Piątkowska
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D000818:Animals; D001835:Body Weight / Q000235:genetics; D002417:Cattle / Q000235:genetics*; D002470:Cell Survival; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D008460:Meat; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D017526:Receptor, IGF Type 1 / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; D005819:Genetic Markers; D017526:Receptor, IGF Type 1