title: Curcumin decreases oxidative stress in mitochondria isolated from liver and kidneys of high-fat diet-induced obese mice.
abstract: Oxidative stress plays a key role in obesity and diabetes-related mitochondrial dysfunction. Mitochondrial dysfunction is characterized by increased oxidative damage, nitric oxide (NO) synthesis, and a reduced ratio of adenosine-5'-triphosphate (ATP) production/oxygen consumption. Curcumin represents a potential antioxidant and anti-inflammatory agent. In this study, our objective was to determine the effect of curcumin treatment on oxidative stress and mitochondrial dysfunction in high-fat diet (HFD)-induced obese mice (OM). These results suggest that curcumin treatment increased oxygen consumption and significantly decreased lipid and protein oxidation levels in liver mitochondria isolated from HFD-induced OM compared with those in the untreated OM (UOM). In kidney mitochondria, curcumin treatment significantly increased oxygen consumption and decreased lipid and protein peroxidation levels in HFD-induced OM when compared with those in UOM. Curcumin treatment neither has any effect on body weight gain nor have any effects on mitochondrial NO synthesis. These findings suggest that obesity induces oxidative stress and mitochondrial dysfunction, whereas curcumin may have a protective role against obesity-induced oxidative stress and mitochondrial dysfunction.
authors.affiliation: a Departamento de Medicina y Nutrición , Universidad de Guanajuato , Campus León , León, Gto. , Mexico.
authors.forename: Antonia
authors.initials: A
authors.lastname: Martínez-Morúa
authors.forename: María G
authors.initials: MG
authors.lastname: Soto-Urquieta
authors.forename: Elena
authors.initials: E
authors.lastname: Franco-Robles
authors.forename: Ismael
authors.initials: I
authors.lastname: Zúñiga-Trujillo
authors.forename: Alejandra
authors.initials: A
authors.lastname: Campos-Cervantes
authors.forename: Victoriano
authors.initials: V
authors.lastname: Pérez-Vázquez
authors.forename: Joel
authors.initials: J
authors.lastname: Ramírez-Emiliano
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology*; D059305:Diet, High-Fat; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008820:Mice, Obese / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D009765:Obesity / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D009569:Nitric Oxide; D003474:Curcumin