title: Inconclusive results of a systematic review of efficacy of antidepressants on orofacial pain disorders.
abstract: METHODS
  Medline.
  
  
  METHODS
  Single or double blinded randomised controlled trials (RCTs), in patients suffering from orofacial pain disorders, with pain intensity as main outcome measure and antidepressants as treatment modality were included. Study quality was assessed using a 15-item checklist.
  
  
  METHODS
  Two independent investigators extracted the data and a qualitative summary was presented.
  
  
  RESULTS
  Six trials were included; four studies were randomised placebo-controlled trials and two were randomised active-controlled trials. All six trials were of high quality according to the 15-item criteria. Because of the heterogeneity of treatment modalities and the low number of trials per disorder there was limited evidence to support the effectiveness of antidepressants in orofacial pain disorders.
  
  
  CONCLUSIONS
  More randomised controlled trials are needed to come to a firm conclusion for the use of antidepressants for orofacial pain disorders.
authors.affiliation: New York University College of Dentistry, New York, USA.
authors.forename: Dharti N
authors.initials: DN
authors.lastname: Patel
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D005157:Facial Pain / Q000188:drug therapy*; D006801:Humans
chemical_list: D000928:Antidepressive Agents