title: [Effect of hemantane on bioelectric activity of brain in mice with MPTP-induced Parkinson syndrome].
abstract: A single intraperitoneal injection of MPTP neurotoxin (30 mg/kg) in C57BL/6 mice causes desynchronization of EEG with a decrease of theta-1 activity and a growth of beta activity in the interval of 15-30 Hz. Subchronic administration of the new antiparkinsonian drug hemantane (injection form) in a dose of 10 mg/kg makes the power of MPTP-induced beta oscillations less pronounced and leads to its reliable decrease within 24 h. This effect of hemantane administration was manifested during the entire period of observations.
authors.forename: I G
authors.initials: IG
authors.lastname: Kapitsa
authors.forename: I I
authors.initials: II
authors.lastname: Kokshenev
authors.forename: L N
authors.initials: LN
authors.lastname: Nerobkova
authors.forename: E A
authors.initials: EA
authors.lastname: Val'dman
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001611:Beta Rhythm / Q000187:drug effects*; D020267:MPTP Poisoning / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D051379:Mice; D010302:Parkinson Disease, Secondary / Q000188:drug therapy / Q000503:physiopathology*; D013826:Theta Rhythm / Q000187:drug effects*; D013997:Time Factors
chemical_list: C526127:hemantane; D000218:Adamantane