title: Edema is a sign of early acute myocardial infarction on post-mortem magnetic resonance imaging.
abstract: The aim of this study was to investigate if acute myocardial infarction can be detected by post-mortem cardiac magnetic resonance (PMMR) at an earlier stage than by traditional autopsy, i.e., within less than 4 h after onset of ischemia; and if so, to determine the characteristics of PMMR findings in early acute infarcts. Twenty-one ex vivo porcine hearts with acute myocardial infarction underwent T2-weighted cardiac PMMR imaging within 3 h of onset of iatrogenic ischemia. PMMR imaging findings were compared to macroscopic findings. Myocardial edema induced by ischemia and reperfusion was visible on PMMR in all cases. Typical findings of early acute ischemic injury on PMMR consist of a central zone of intermediate signal intensity bordered by a rim of increased signal intensity. Myocardial edema can be detected on cardiac PMMR within the first 3 h after the onset of ischemia in porcine hearts. The size of myocardial edema reflects the area of ischemic injury in early acute (per-acute) myocardial infarction. This study provides evidence that cardiac PMMR is able to detect acute myocardial infarcts at an earlier stage than traditional autopsy and routine histology.
authors.affiliation: Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Winterthurerstrasse 190/52, 8057, Zurich, Switzerland, thomas.ruder@irm.uzh.ch.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Ruder
authors.forename: Lars C
authors.initials: LC
authors.lastname: Ebert
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Khattab
authors.forename: Robert
authors.initials: R
authors.lastname: Rieben
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Thali
authors.forename: Pranitha
authors.initials: P
authors.lastname: Kamat
mesh_terms: D000818:Animals; D001344:Autopsy; D004489:Edema, Cardiac / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D013552:Swine; D013997:Time Factors