title: Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients.
abstract: Increases in the generation of reactive oxygen species and decreases in antioxidant enzyme activities with aging have been reported in the prostate, and are also observed in age-related disorders such as atherosclerosis, Alzheimer's disease, and cataracts. Several studies have demonstrated that proteins are targets for reactive oxidants in cells, and that oxidized proteins accumulate during aging, oxidative stress and in some pathological conditions. However, only a limited number of studies have actually evaluated oxidative damage in relation to HDL-cholesterol-associated antioxidant enzyme activities or have assessed its relationship with prostate cancer. In this study, we examined the effect of HDL-cholesterol-associated antioxidant enzyme activities, paraoxonase1, arylesterase and new oxidative stress parameters (total oxidant status, total antioxidant status [and oxidative stress index]) in newly-diagnosed prostate cancer patients and healthy controls. There were no significant differences in oxidative stress parameters and lipid parameters between prostate cancer patients and controls, however, paraoxonase1 enzyme activity, and non-HDL-cholesterol levels were higher in prostate cancer patients than controls. The results of this study were derived from a small number of subjects, but might represent an important working hypothesis for further research in a larger number of cases to clarify the role of paraoxonase1 overproduction on the prostate and its clinical relevance.
authors.affiliation: Urology Clinic of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Eroglu
authors.forename: Necat
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Soner
authors.initials: S
authors.lastname: Yalcinkaya
authors.forename: Nurullah
authors.initials: N
authors.lastname: Ay
authors.forename: Ozgur
authors.initials: O
authors.lastname: Aydin
authors.forename: Cem
authors.initials: C
authors.lastname: Sezer
mesh_terms: D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood / Q000235:genetics*; D002265:Carboxylic Ester Hydrolases / Q000097:blood / Q000235:genetics; D002277:Carcinoma / Q000097:blood* / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D015870:Gene Expression; D006801:Humans; D007610:Kallikreins / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017430:Prostate-Specific Antigen / Q000097:blood / Q000235:genetics; D011471:Prostatic Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology; D017382:Reactive Oxygen Species / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D017382:Reactive Oxygen Species; D014280:Triglycerides; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen