title: Reduction of cytotoxicity of natural rubber latex film by coating with PMMA-chitosan nanoparticles.
abstract: Poly(methyl methacrylate) (PMMA) latex stabilized by chitosan (CS) oligomer was synthesized via the miniemulsion polymerization. By using 1% CS solution (in 0.1M acetic acid), the spherical PMMA-CS particles with an average size of 380 nm were obtained. The positive zeta potentials at pH 2-7 confirmed the presence of CS as the outermost layer of the latex particles. Therefore, these particles directly interacted with the indigenous non-rubbers at the surface of sulphur prevulcanized natural rubber (SPNR) film. The deposition of PMMA-CS particles caused an increase in surface roughness of the coated SPNR film as a function of latex concentration and immersion time. The simple coating of the rubber substrate with PMMA-CS particles effectively reduced the in vitro cytotoxicity on L-929 cells. This study would be, therefore, helpful for development of latex gloves designed for hypersensitive users.
authors.affiliation: Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Phyathai, Bangkok 10400, Thailand.
authors.forename: Nuttakun
authors.initials: N
authors.lastname: Kanjanathaworn
authors.forename: Duangporn
authors.initials: D
authors.lastname: Polpanich
authors.forename: Kulachart
authors.initials: K
authors.lastname: Jangpatarapongsa
authors.forename: Pramuan
authors.initials: P
authors.lastname: Tangboriboonrat
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D012408:Rubber / Q000737:chemistry* / Q000633:toxicity; D013499:Surface Properties
chemical_list: D012408:Rubber; D019904:Polymethyl Methacrylate; D048271:Chitosan