title: Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells.
abstract: OBJECTIVE
  The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus.
  
  
  METHODS
  Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI ≥ 4) or "inactive" (SLEDAI < 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation.
  
  
  RESULTS
  The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality.
  
  
  CONCLUSIONS
  cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration.
authors.affiliation: New York University School of Medicine, Cancer Institute, Smilow Research Building 1303, 522 First Avenue, New York, NY 10016, U.S.A.
authors.forename: Shaukat Ali
authors.initials: SA
authors.lastname: Khan
authors.affiliation: New York University School of Medicine, Cancer Institute, Smilow Research Building 1303, 522 First Avenue, New York, NY 10016, U.S.A.|New York University School of Medicine, Department of Medicine, Division of Rheumatology, NYU Hospital for Joint Diseases, 301 E 17th Street, New York, NY 10003, U.S.A.
authors.forename: Johannes
authors.initials: J
authors.lastname: Nowatzky
authors.affiliation: New York University School of Medicine, Cancer Institute, Smilow Research Building 1303, 522 First Avenue, New York, NY 10016, U.S.A.
authors.forename: Sonia
authors.initials: S
authors.lastname: Jiménez-Branda
authors.affiliation: New York University School of Medicine, Department of Medicine, Division of Rheumatology, NYU Hospital for Joint Diseases, 301 E 17th Street, New York, NY 10003, U.S.A.
authors.forename: Jeffrey David
authors.initials: JD
authors.lastname: Greenberg
authors.affiliation: New York University School of Medicine, Department of Medicine, Division of Rheumatology, NYU Hospital for Joint Diseases, 301 E 17th Street, New York, NY 10003, U.S.A.
authors.forename: Robert
authors.initials: R
authors.lastname: Clancy
authors.affiliation: New York University School of Medicine, Department of Medicine, Division of Rheumatology, NYU Hospital for Joint Diseases, 301 E 17th Street, New York, NY 10003, U.S.A.
authors.forename: Jill
authors.initials: J
authors.lastname: Buyon
authors.affiliation: New York University School of Medicine, Cancer Institute, Smilow Research Building 1303, 522 First Avenue, New York, NY 10016, U.S.A.
authors.forename: Nina
authors.initials: N
authors.lastname: Bhardwaj
mesh_terms: D003713:Dendritic Cells / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology
keywords: Autoimmunity; Dendritic cells; Disease activity; Systemic lupus erythematosus