title: Cerebral Wegener's granuloma: surgery mandatory for diagnosis and treatment.
abstract: The involvement of the central nervous system in case of Wegener granulomatosis (WG) is infrequent and usually leads to cranial nerve abnormalities, cerebrovascular events, and seizures. Meningeal involvement is quite rare and usually is due to the spreading from adjacent disease in the skull base. We described the case of a remote intraparenchymal Wegener's granuloma in a 55-year-old man presenting with seizures and a history of severe generalized WG. The radiological findings were not useful for the diagnosis, and the pharmacological treatment was ineffective. The importance of a surgery in case of localized WG has been emphasized, in order to confirm the diagnosis and to avoid additional medicaments, like antiepileptic drugs, potentially harmful in immunosuppressed patients.
authors.affiliation: Division of Neurosurgery, Department of Neuroscience, University of Brescia, Brescia, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Nicolosi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Nodari
authors.forename: Giannantonio
authors.initials: G
authors.lastname: Spena
authors.forename: Elena
authors.initials: E
authors.lastname: Roca
authors.forename: Karol
authors.initials: K
authors.lastname: Migliorati
authors.forename: Giacomo
authors.initials: G
authors.lastname: Esposito
authors.forename: Roberto
authors.initials: R
authors.lastname: Stefini
authors.forename: Marco
authors.initials: M
authors.lastname: Fontanella
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Panciani