title: Necrotizing skin lesion and radial nerve palsy in a patient treated with glatiramer acetate.
abstract: Glatiramer acetate (GA) is an approved and well tolerated drug for the treatment of relapsing-remitting multiple sclerosis. We report a case of a 52 year-old man with psoriasis and relapsing-remitting multiple sclerosis who developed, after 21 months of GA treatment, an injection-site cutaneous necrosis that involved both subcutaneous and muscular tissue with massive edema, followed, 3 days later, by radial nerve palsy. After few days another similar lesion appeared in another injection-site. We hypothesize that cutaneous necrosis could be due to a local dis-immune reaction and, probably, psoriasis could have played an important role in its pathogenesis.
authors.affiliation: Department of Neurological Sciences, Federico II University of Naples, Naples, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Carotenuto
authors.forename: Rosa
authors.initials: R
authors.lastname: Iodice
authors.forename: Francesco
authors.initials: F
authors.lastname: Barbato
authors.forename: Nicola Salvatore
authors.initials: NS
authors.lastname: Orefice
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Orefice
mesh_terms: D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy; D010455:Peptides / Q000009:adverse effects*; D020425:Radial Neuropathy / Q000139:chemically induced*; D012871:Skin Diseases / Q000139:chemically induced*
chemical_list: D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate
keywords: Autoimmune diseases; Glatiramer acetate; Multiple sclerosis; Necrotizing lesion; Radial nerve palsy; Skin reaction