title: [Basic mechanisms: structure, function and metabolism of plasma lipoproteins].
abstract: The aim of this work is to present basic information on the lipoprotein physiology. The protein fraction of lipoproteins consists of several apolipoproteins and enzymes whose functions are lipid transport and metabolism. Classification of lipoproteins is based on their density. Chylomicrons, VLDL, IDL, LDL and HDL can be isolated by ultracentrifugation. Both chylomicrons- and VLDL-triglycerides are transported from the intestine and liver, respectively, to the peripheral tissues. The metabolism of VLDL originates IDL and LDL. LDL is the main transporter of cholesterol to extrahepatic tissues. HDL mobilizes cholesterol from peripheral tissues to the liver where it is secreted to bile as free cholesterol or bile salts, a process termed reverse cholesterol transport. Lipoprotein metabolism can be regulated by nuclear receptors that regulate the expression of genes involved in triglyceride and apolipoprotein metabolism.
authors.affiliation: IIB Sant Pau, Barcelona, España.
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Errico
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Chen
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Martin Campos
authors.forename: Josep
authors.initials: J
authors.lastname: Julve
authors.forename: Joan Carles
authors.initials: JC
authors.lastname: Escolà-Gil
authors.forename: Francisco
authors.initials: F
authors.lastname: Blanco-Vaca
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001692:Biological Transport / Q000502:physiology; D002784:Cholesterol / Q000378:metabolism*; D002914:Chylomicrons / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001053:Apolipoproteins; D001647:Bile Acids and Salts; D002914:Chylomicrons; D008074:Lipoproteins; D018160:Receptors, Cytoplasmic and Nuclear; D014280:Triglycerides; D002784:Cholesterol
keywords: Apolipoprotein; Apolipoproteína; Cholesterol; Colesterol; Lipoprotein; Lipoproteína; Triglicérido; Triglyceride