title: Combination of Steven-Johnson syndrome and neuroleptic malignant syndrome following carbamazepine therapy: a rare occurrence.
abstract: Stevens-Johnson syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction that is most often elicited by drugs and occasionally by infections. The drugs commonly implicated as the cause of SJS are anticonvulsants, sulfonamides, non-steroidal anti-inflammatory drugs and antibiotics. Carbamazepine (CBZ) has been commonly implicated in SJS. Neuroleptic malignant syndrome (NMS) is a rare, life-threatening but potentially treatable condition. Among the neuroleptics, haloperidol (parenteral) is implicated as a most common drug for NMS. Though rare, association of NMS with CBZ and association of NMS with toxic epidermal necrolysis (TEN) in a single patient after administration of neuroleptics has been reported in the literature before. However, a combination of NMS and SJS in a single patient after administration of CBZ has not been reported so far. We present a patient with seizure who developed SJS and NMS following administration of CBZ.
authors.affiliation: Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India. sharmadrbhawna@gmail.com
authors.forename: Bhawna
authors.initials: B
authors.lastname: Sharma
authors.forename: Raghavendra Bakki
authors.initials: RB
authors.lastname: Sannegowda
authors.forename: Pankaj
authors.initials: P
authors.lastname: Gandhi
authors.forename: Parul
authors.initials: P
authors.lastname: Dubey
authors.forename: Ashok
authors.initials: A
authors.lastname: Panagariya
mesh_terms: D000293:Adolescent; D002220:Carbamazepine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
chemical_list: D002220:Carbamazepine