title: Cytometry, immunology, and HIV infection: three decades of strong interactions.
abstract: Flow cytometry (FCM) has been extensively used to investigate immunological changes that occur from infection with the human immunodeficiency virus (HIV). This review describes some of the most relevant cellular and molecular changes in the immune system that can be detected by FCM during HIV infection. Finally, it will be discussed how this technology has facilitated the understanding not only of the biology of the virus but also of the mechanisms that the immune system activates to fight HIV and is allowing to monitor the efficacy of antiretroviral therapy.
authors.affiliation: Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy. andrea.cossarizza@unimore.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Cossarizza
authors.forename: Sara
authors.initials: S
authors.lastname: De Biasi
authors.forename: Lara
authors.initials: L
authors.lastname: Gibellini
authors.forename: Elena
authors.initials: E
authors.lastname: Bianchini
authors.forename: Regina
authors.initials: R
authors.lastname: Bartolomeo
authors.forename: Milena
authors.initials: M
authors.lastname: Nasi
authors.forename: Cristina
authors.initials: C
authors.lastname: Mussini
authors.forename: Marcello
authors.initials: M
authors.lastname: Pinti
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D005434:Flow Cytometry; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000821:virology; D008213:Lymphocyte Activation; D012157:Mononuclear Phagocyte System / Q000276:immunology / Q000821:virology
keywords: AIDS; HIV; cytometry; immune system