title: The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson's disease.
abstract: OBJECTIVE
  To evaluate the motor experiences of daily living section of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS M-EDL) for assessing disability in PD patients; to determine the association between disability and quality of life; and to identify cut-off score ranges for no, mild, moderate and severe disability with this measure.
  
  
  METHODS
  International, observational, cross-sectional study of 435 PD patients, assessed with: MDS-UPDRS, Hoehn and Yahr staging, Rapid Assessment of Disability Scale, Clinical Impression of Severity Index for PD, Parkinson's Disease Questionnaire-8 and EQ-5D. Descriptive statistics, Spearman's rank correlation coefficients, Kruskal-Wallis test for group comparisons, ordinal logistic regression analysis for setting cut-off values and a step-wise multiple linear regression model were calculated.
  
  
  RESULTS
  MDS-UPDRS M-EDL correlated 0.70-0.80 with other disability measures, and -0.46 to 0.74 with quality of life scales. Scores significantly increased with higher disease duration and severity (p < 0.001). Cut-off values for the M-EDL were: 0-2 points, no disability; 3-16, mild; 17-31, moderate; and 32 points or more, severe. Linear regression analysis identified the MDS-UPDRS nM-EDL section as the main determinant of M-EDL, followed by the rest of MDS-UPDRS sections (explained variance: 59%).
  
  
  CONCLUSIONS
  MDS-UPDRS M-EDL proved to be useful for assessing disability in PD.
authors.affiliation: National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Rodriguez-Blazquez
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Rojo-Abuin
authors.forename: Mario
authors.initials: M
authors.lastname: Alvarez-Sanchez
authors.forename: Tomoko
authors.initials: T
authors.lastname: Arakaki
authors.forename: Alberto
authors.initials: A
authors.lastname: Bergareche-Yarza
authors.forename: Anabel
authors.initials: A
authors.lastname: Chade
authors.forename: Nelida
authors.initials: N
authors.lastname: Garretto
authors.forename: Oscar
authors.initials: O
authors.lastname: Gershanik
authors.forename: Monica M
authors.initials: MM
authors.lastname: Kurtis
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Martinez-Castrillo
authors.forename: Amelia
authors.initials: A
authors.lastname: Mendoza-Rodriguez
authors.forename: Henry P
authors.initials: HP
authors.lastname: Moore
authors.forename: Mayela
authors.initials: M
authors.lastname: Rodriguez-Violante
authors.forename: Carlos
authors.initials: C
authors.lastname: Singer
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Tilley
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.forename: Glenn T
authors.initials: GT
authors.lastname: Stebbins
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Goetz
authors.forename: Pablo
authors.initials: P
authors.lastname: Martinez-Martin
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006304:Health Status; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011597:Psychomotor Performance / Q000502:physiology; D011788:Quality of Life; D015203:Reproducibility of Results; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
keywords: Assessment; Disability; MDS-UPDRS; Parkinson's disease; Rating scales