title: Genomic positions of co-expressed genes: echoes of chromosome organisation in gene expression data.
abstract: BACKGROUND
  The relationships between gene expression and nuclear structure, chromosome territories in particular, are currently being elucidated experimentally. Each chromosome occupies an individual, spatially-limited space with a preferential position relative to the nuclear centre that may be specific to the cell and tissue type. We sought to discover whether patterns in gene expression databases might exist that would mirror prevailing or recurring nuclear structure patterns, chromosome territory interactions in particular.
  
  
  RESULTS
  We used human gene expression datasets, both from a tissue expression atlas and from a large set including diverse types of perturbations. We identified groups of positional gene clusters over-represented in gene expression clusters. We show that some pairs of chromosomes and pairs of 10 Mbp long chromosome regions are significantly enriched in the expression clusters. The functions of genes involved in inter-chromosome co-expression relationships are non-random and predominantly related to cell-cell communication and reaction to external stimuli.
  
  
  CONCLUSIONS
  We suggest that inter-chromosomal gene co-expression can be interpreted in the context of nuclear structure, and that even expression datasets that include very diverse conditions and cell types show consistent relationships.
authors.affiliation: Nencki Institute of Experimental Biology, PAS, Pasteura 3, Warsaw 02-093, Poland. tereski@ibb.waw.pl
authors.forename: Teresa
authors.initials: T
authors.lastname: Szczepińska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Pawłowski
mesh_terms: D002874:Chromosome Mapping; D016000:Cluster Analysis; D015870:Gene Expression; D006801:Humans