title: Survival time and prognostic factors in cats with newly diagnosed diabetes mellitus: 114 cases (2000-2009).
abstract: OBJECTIVE
  To determine overall survival time and identify prognostic factors associated with survival time in cats with newly diagnosed diabetes mellitus.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  114 cats with newly diagnosed diabetes mellitus.
  
  
  METHODS
  Data for analysis included history, signalment, physical examination findings, hematologic and serum biochemical data, presence of ketoacidosis, and diagnosis of concurrent diseases at initial evaluation. The effects of possible predictors on survival time were determined by calculating hazard ratios (HRs) and 95% confidence intervals (CIs).
  
  
  RESULTS
  Median survival time of diabetic cats was 516 days (range, 1 to 3,468 days); 70%, 64%, and 46% lived longer than 3, 6, and 24 months, respectively. Survival time was significantly shorter for cats with higher creatinine concentrations, with a hazard of dying approximately 5% greater for each increase of 10 μg/dL in serum creatinine concentration (adjusted HR, 1.005; 95% CI, 1.003 to 1.007). Ketoacidosis was not significantly associated with survival time (HR, 1.02; 95% CI, 0.590 to 1.78).
  
  
  CONCLUSIONS
  Cats with newly diagnosed diabetes mellitus had a fair to good prognosis. High serum creatinine concentration at diagnosis was associated with a poor outcome, likely because of the adverse effects of renal dysfunction. Ketoacidosis apparently was not associated with decreased survival time, suggesting that this complication should not necessarily be regarded as unfavorable.
authors.affiliation: Istituto Veterinario di Novara, Granozzo con Monticello (NO), Italy.
authors.forename: Carolina
authors.initials: C
authors.lastname: Callegari
authors.forename: Edy
authors.initials: E
authors.lastname: Mercuriali
authors.forename: Michaela
authors.initials: M
authors.lastname: Hafner
authors.forename: Luigi M
authors.initials: LM
authors.lastname: Coppola
authors.forename: Stefano
authors.initials: S
authors.lastname: Guazzetti
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Lutz
authors.forename: Claudia E
authors.initials: CE
authors.lastname: Reusch
authors.forename: Eric
authors.initials: E
authors.lastname: Zini
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D002415:Cats; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D005260:Female; D007328:Insulin / Q000627:therapeutic use; D007662:Ketosis / Q000662:veterinary; D008297:Male
chemical_list: D007328:Insulin; D003404:Creatinine