title: [Hepatoduodenal circulation and excretion of the new GABA derivative citrocard].
abstract: Pharmacokinetic investigation of a new gamma-aminobutyric acid (GABA) derivative cirtocard showed that, upon the intravenous introduction, the drug is determined in high concentrations in organs of elimination--the liver and kidneys. The tissue accessibility amounts to 1.341 for the liver and 4.053 for the kidneys and the separation factor is 1.041 for the liver and 4.486 for the kidneys. The study of drug excretion showed that cirtocard is determined in the urine for 48 h, its nephritic clearance being 0.047 L/h and extra-nephritic clearance, 0.33 L/h. For the unchanged substance, a large significance ofhepatoduodenal circulation is low probable, since no more than 1 - 2% of the introduced dose was isolated with bile over entire experiment. It is established that the removal of the unchanged substance does not exceed 10% of the introduced dose. There is high probability of hepatoduodenal circulation and excretion of the preparation in the form of metabolites.
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: L A
authors.initials: LA
authors.lastname: Smirnova
authors.forename: A F
authors.initials: AF
authors.lastname: Riabukha
authors.forename: E A
authors.initials: EA
authors.lastname: Suchkov
authors.forename: S A
authors.initials: SA
authors.lastname: Lebedeva
mesh_terms: D000818:Animals; D019343:Citric Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000494:pharmacology; D004386:Duodenum / Q000378:metabolism*; D018755:GABA Agonists / Q000493:pharmacokinetics* / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D018755:GABA Agonists; D019343:Citric Acid; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid