title: Meta-analyses of HFE variants in coronary heart disease.
abstract: OBJECTIVE
  HFE gene variants can cause hereditary hemochromatosis (HH) that often comes along with an increased risk of coronary heart disease (CHD). The goal of our study is to assess the contribution of four HFE gene variants to the risk of CHD.
  
  
  RESULTS
  We conducted four meta-analyses of the studies examining the association between four HFE gene variants and the risk of CHD. A systematic search was conducted using MEDLINE, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI), Wanfang Chinese Periodical.
  
  
  RESULTS
  Meta-analyses showed that HFE rs1799945-G allele was associated with a 6% increased risk of CHD (P=0.02, odds ratio (OR)=1.06, 95% confidence interval (CI)=1.01-1.11). However, no association between the other three HFE gene variants (rs1800562, rs1800730, and rs9366637) and CHD risk was observed by the meta-analyses (all P values>0.05). In addition, the results of our case-control study indicated that rs1800562 and rs1800730 were monomorphic, and that rs1799945 and rs9366637 were not associated with CHD in Han Chinese.
  
  
  CONCLUSIONS
  Our meta-analysis suggested that a significant association existed between rs1799945 mutation and CHD, although this mutation was rare in Han Chinese.
authors.affiliation: Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
authors.forename: Jiangfang
authors.initials: J
authors.lastname: Lian
authors.forename: Limin
authors.initials: L
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Yanping
authors.initials: Y
authors.lastname: Le
authors.forename: Danjie
authors.initials: D
authors.lastname: Jiang
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Weifeng
authors.initials: W
authors.lastname: Xu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Huang
authors.forename: Changzheng
authors.initials: C
authors.lastname: Dong
authors.forename: Meng
authors.initials: M
authors.lastname: Ye
authors.forename: Jianqing
authors.initials: J
authors.lastname: Zhou
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
mesh_terms: D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D006239:Haplotypes; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008565:Membrane Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins
keywords: 95% CI; 95% confidence interval; CHD; Coronary heart disease; HFE; HH; HWE; Hardy–Weinberg equilibrium; Hereditary hemochromatosis; OR; SNP; coronary heart disease; hereditary hemochromatosis; odds ratio; rs1799945; single nucleotide polymorphism