title: Development and validation of the simultaneous UV spectrophotometric method for estimation of metoprolol succinate and olmesartan medoxomil in the tablet dosage form.
abstract: BACKGROUND
  A simple, rapid, accurate, precise, and economical UV spectrophotometric method for the simultaneous determination of metoprolol succinate (METO) and olmesartan medoxomil (OLME) in a combined tablet dosage form using the simultaneous equation method has been developed.
  
  
  METHODS
  The method is based on the simultaneous equations for analysis of both the drugs using distilled water as a solvent. METO has absorbance maxima at 221 nm and OLME has absorbance maxima at 257 nm in distilled water.
  
  
  RESULTS
  The linearity was obtained in the concentration range of 5-25 μg/ml and 4-20 μg/ml for METO and OLME, respectively. The concentrations of the drugs were determined by using the simultaneous equations method. The mean recovery was 100.90 ± 1.76 and 100.26 ± 0.71 for METO and OLME, respectively.
  
  
  CONCLUSIONS
  The method was found to be simple, accurate, and precise and was applicable for the simultaneous determination of METO and OLME in the pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
authors.affiliation: APMC College of Pharmaceutical Education and Research, College Campus, Motipura, Himmatnagar 383 001, India.
authors.forename: Bindi N
authors.initials: BN
authors.lastname: Vora
authors.forename: Rajesh R
authors.initials: RR
authors.lastname: Parmar
authors.forename: Pratik P
authors.initials: PP
authors.lastname: Nayak
authors.forename: Dushyant A
authors.initials: DA
authors.lastname: Shah
keywords: Distilled water; metoprolol succinate; olmesartan medoxomil; recovery; simultaneous equations; validation