title: Fiberoptic bronchoscopy, as a valuable diagnostic option in sputum negative pulmonary tuberculosis: A prospective study.
abstract: BACKGROUND
  World Health Organization recommends bacteriological confirmation of pulmonary tuberculosis (PTB) by the detection of acid-fast bacilli (AFB) in respiratory specimens. However about 40-60% of patients with PTB suspected clinically or radiologically may fail to produce sputum, or when it is available, AFB may be negative on repeated smear examination. These sputum smear negative patients and those who fail to produce any sputum can be diagnosed by flexible fiberoptic bronchoscopy.
  
  
  OBJECTIVE
  Our study was an attempt to analyze the role of fiberoptic bronchoscopy in sputum smear negative PTB patients with respect to their association with clinical and radiological profile.
  
  
  METHODS
  In this prospective, open label, observational study, 40 cases of sputum smear negative PTB were subjected to bronchoscopic examination after taking informed consent and samples like bronchial aspirate, bronchoalveolar lavage and post bronchoscopy sputum were collected. The data was analysed and the results were given in percentage.
  
  
  RESULTS
  Out of the total 40 patients, overall diagnosis was confirmed in 24 (60%) patients. Of these 24 patients, 17 patients were confirmed for PTB whereas 7 had other diagnoses.
  
  
  CONCLUSIONS
  The study concludes that fiberoptic bronchoscopy is a useful tool in diagnosing sputum smear negative PTB patients with respect to their association with clinical and radiological profile, and also identifies individuals at a higher risk for progression of disease, at an early stage despite not meeting routine bacteriological criteria for confirmation of PTB.
authors.affiliation: Department of Medicine, J. N. Medical College, AMU, Aligarh, India.
authors.forename: Saif
authors.initials: S
authors.lastname: Quaiser
authors.forename: Anil
authors.initials: A
authors.lastname: Agarwal
authors.forename: Ruhi
authors.initials: R
authors.lastname: Khan
authors.forename: Shahzad F
authors.initials: SF
authors.lastname: Haque
keywords: AFB-negative; AFB-negative sputum; fiberoptic bronchoscopy; pulmonary tuberculosis