title: Evaluation of the antigingivitis effect of a chlorhexidine mouthwash with or without an antidiscoloration system compared to placebo during experimental gingivitis.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the effectiveness of chlorhexidine (CHX) with an antidiscoloration system (ADS) on stain, plaque accumulation, and gingivitis.
  
  
  METHODS
  A randomized, controlled clinical trial was conducted in 26 students. After a preparatory period, the students were randomly assigned to either group P (placebo), group T1 (0.12% CHX without an ADS), or group T2 (0.12% CHX with an ADS). During the 3-week experimental period, all mechanical oral hygiene was abolished. Rinsing with 10 mL mouthwash or placebo was performed twice daily under supervision. The parameters assessed on days 0, 7, 14, and 21 included the Discoloration Index (DI), Plaque Index (PII), and Gingival Index (GI).
  
  
  RESULTS
  There were no significant mean differences in the DI, PII, or GI between groups T2 and P. Significant mean differences existed in the DI between groups T2 and T1 on days 14 and 21. Significant mean differences existed in the PI between groups T2 and T1 on days 7, 14, and 21. Likewise, significant mean differences existed in the GI between groups T2 and T1 on days 14 and 21.
  
  
  CONCLUSIONS
  CHX with an ADS did not prevent plaque or gingivitis development. In fact, the CHX mouthwash with an ADS showed no superior effect over placebo on oral hygiene or the prevention of gingivitis.
authors.affiliation: Prince Philip Dental Hospital, Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Ren E
authors.initials: RE
authors.lastname: Wang
authors.forename: Martin
authors.initials: M
authors.lastname: Finger
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
mesh_terms: D000293:Adolescent; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D016022:Case-Control Studies; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index; D010919:Placebos; D014075:Tooth Discoloration / Q000145:classification / Q000517:prevention & control*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D010919:Placebos; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
keywords: antidiscoloration system; antigingivitis effect; chlorhexidine; mouthrinse; staining