title: A case of acute pulmonary embolism associated with dysplasminogenemia.
abstract: The incidence of pulmonary embolism (PE) rises markedly with age, and only a few cases have been reported in younger adults. Thrombophilia has been reported as one of the predisposing factors for PE in younger adults. Here we report an extraordinary case of PE complicated with dysplasminogenemia, a rare genetic disorder resulting in hypercoagulability, in a young male. An 18-yr-old male visited an emergency room in the United States complaining chest discomfort. He was diagnosed as PE with deep vein thrombosis without apparent risk factors. Anticoagulation therapy with warfarin had been initiated and discontinued after 6 months of treatment. After returning to Korea he was tested for thrombophilia which revealed decreased activity of plasminogen and subsequent analysis of PLG gene showed heterozygous Ala620Thr mutation. He was diagnosed with PE complicated with dysplasminogenemia. Life-long anticoagulation therapy was initiated. He is currently under follow-up without clinical events for 2 yr.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hongseok
authors.initials: H
authors.lastname: Yoo
authors.forename: Hee-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Chin A
authors.initials: CA
authors.lastname: Yi
authors.forename: Yoon Young
authors.initials: YY
authors.lastname: Cho
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Joung
authors.forename: Hyemin
authors.initials: H
authors.lastname: Jeong
authors.forename: Kyeongman
authors.initials: K
authors.lastname: Jeon
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D003231:Conjunctivitis / Q000150:complications / Q000175:diagnosis*; D006579:Heterozygote; D006801:Humans; D008297:Male; D010958:Plasminogen / Q000172:deficiency* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D012307:Risk Factors; D012873:Skin Diseases, Genetic / Q000150:complications / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000209:etiology; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D010958:Plasminogen
keywords: Deficiency; Diagnosis; Plasminogen; Pulmonary Embolism; Venous Thromboembolism