title: Leptin concentration and nutritional status in the course of treatment in children with brain tumours--preliminary report.
abstract: OBJECTIVE
  To assess the nutritional status in children with central nervous system (CNS) tumours, including concentration of leptin, the neuropeptide responsible for regulation of energetic homeostasis in an organism.
  
  
  METHODS
  The studied group comprised 44 children with brain tumours, aged (4.02-18.7). In all children during the whole therapy (from the start to the period of 1 year and more after the end of therapy), a number of standard deviations (SDs) for the body mass index (SDS BMI) was derived from anthropometric measurements. Concentrations of leptin were assayed simultaneously.
  
  
  RESULTS
  The lowest values of the anthropometric indices were found in children during the maintenance therapy. Concentrations of leptin in patients with malignant CNS tumours and significant undernutrition were slightly greater as compared to patients presenting normal nutritional status; however, without statistical significance.
  
  
  CONCLUSIONS
  In children with tumours of the central nervous system, there are quantitative disorders of the nutritional status which correlate with the period of the treatment. The most significant disorders in the nutritional status are observed during maintenance chemotherapy. There was no statistically significant correlation between the concentration of leptin and nutritional status in children with malignant brain tumours during the course of treatment and after its completion.
authors.affiliation: Department of Pediatric Oncology, Hematology, and Chemotherapy, Upper Silesia Children's Care Health Centre, Medical University of Silesia, 16 Medykow Str., 40-752, Katowice, Poland, katkamusiol@gmail.com.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Musiol
authors.forename: Grazyna
authors.initials: G
authors.lastname: Sobol
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Mizia-Malarz
authors.forename: Halina
authors.initials: H
authors.lastname: Wos
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001932:Brain Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D002648:Child; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D020738:Leptin