title: The effect of myocardial fibrosis on left ventricular torsion and twist in patients with non-ischemic dilated cardiomyopathy.
abstract: BACKGROUND
  Left ventricular (LV) rotation, twist, and torsion are important aspects of the cardiac performance. Myocardial fibrosis can be identified as the late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR). In this study, we investigated the association between myocardial fibrosis and LV rotational parameters in patients with nonischemic dilated cardiomyopathy (NDC).
  
  
  METHODS
  Twenty-two NDC patients were enrolled. LV dimensions, volumes and ejection fraction (EF) were measured, conventional tissue Doppler imaging data was acquired. Speckle tracking imaging was performed to measure LV deformation, LV rotational parameters. Blood samples were obtained for NT-proBNP. Late gadolinium enhanced cardiac magnetic resonance (LGE-CMR) was used to assess cardiac fibrosis index.
  
  
  RESULTS
  Myocardial deformation was similar between LGE+ and LGE- groups. LGE+patients have significantly higher basal and lower apical systolic rotation, lower twist and torsion when compared to LGE- patients. However, untwisting rate was similar between the groups. Torsion was significantly correlated with LVEF and MR-index. Patients with reversed apical systolic rotation had significantly greater NT-proBNP values, basal systolic rotation and significantly lower apical systolic rotation, torsion, and MR-index.
  
  
  CONCLUSIONS
  Cardiac fibrosis index is closely related with myocardial torsion and LV systolic function and may be used for the evaluation of cardiac condition. Reversed apical systolicrotation indicated more extensive cardiac fibrosis as it may reflect severe LV dyssynchrony andpoor LV performance.
authors.affiliation: emregurelctf@yahoo.com.
authors.forename: Tansu
authors.initials: T
authors.lastname: Karaahmet
authors.forename: Emre
authors.initials: E
authors.lastname: Gürel
authors.forename: Kursat
authors.initials: K
authors.lastname: Tigen
authors.forename: Ahmet
authors.initials: A
authors.lastname: Güler
authors.forename: Cihan
authors.initials: C
authors.lastname: Dündar
authors.forename: Hakan
authors.initials: H
authors.lastname: Fotbolcu
authors.forename: Yelda
authors.initials: Y
authors.lastname: Basaran
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001696:Biomechanical Phenomena; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003287:Contrast Media; D015150:Echocardiography, Doppler; D005260:Female; D005355:Fibrosis; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009942:Organometallic Compounds; D010446:Peptide Fragments / Q000097:blood; D054159:Torsion, Mechanical; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D009942:Organometallic Compounds; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D008536:Meglumine; C072417:gadoterate meglumine