title: The mechanism of inhibition by H2 of H2-evolution by hydrogenases.
abstract: By analysing the results of experiments carried out with two FeFe hydrogenases and several "channel mutants" of a NiFe hydrogenase, we demonstrate that whether or not hydrogen evolution is significantly inhibited by H2 is not a consequence of active site chemistry, but rather relates to H2 transport within the enzyme.
authors.affiliation: CNRS, Aix-Marseille Université, BIP UMR 7281, 13009, Marseille, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Fourmond
authors.forename: Carole
authors.initials: C
authors.lastname: Baffert
authors.forename: Kateryna
authors.initials: K
authors.lastname: Sybirna
authors.forename: Sébastien
authors.initials: S
authors.lastname: Dementin
authors.forename: Abbas
authors.initials: A
authors.lastname: Abou-Hamdan
authors.forename: Isabelle
authors.initials: I
authors.lastname: Meynial-Salles
authors.forename: Philippe
authors.initials: P
authors.lastname: Soucaille
authors.forename: Hervé
authors.initials: H
authors.lastname: Bottin
authors.forename: Christophe
authors.initials: C
authors.lastname: Léger
mesh_terms: D006859:Hydrogen / Q000737:chemistry / Q000378:metabolism*; D006864:Hydrogenase / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000378:metabolism*; D008958:Models, Molecular
chemical_list: D007506:Iron-Sulfur Proteins; D006859:Hydrogen; C118830:iron hydrogenase; C043296:nickel-iron hydrogenase; D006864:Hydrogenase