title: Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1.
abstract: ABCG1 is a half-sized transporter with an unquestionable importance in cholesterol homeostasis. So far, its expression and thus its activity was suggested to be regulated at transcriptional level by LXR and PPAR agonists including polyphenols. However, it is unknown whether there are other mechanisms of up-regulation of ABCG1 activity. In the present work resveratrol was shown to induce a nearly twofold increase in ATPase activity of reconstituted ABCG1. Evidence is presented for the first time suggesting that resveratrol is able to activate ABCG1 activity by an alternative mechanism that involves an indirect interaction.
authors.affiliation: Instituto Superior de Investigaciones Biológicas (CONICET-UNT), Instituto de Química Biológica Dr. Bernabe Bloj, San Miguel de Tucumán, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: de Athayde Moncorvo Collado
authors.forename: Natalia
authors.initials: N
authors.lastname: Corbalán
authors.forename: László
authors.initials: L
authors.lastname: Homolya
authors.forename: Roberto
authors.initials: R
authors.lastname: Morero
authors.forename: Carlos
authors.initials: C
authors.lastname: Minahk
mesh_terms: D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D006801:Humans; D008081:Liposomes; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: C419353:ABCG1 protein, human; D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1; D018528:ATP-Binding Cassette Transporters; D008081:Liposomes; D013267:Stilbenes; D000251:Adenosine Triphosphatases; D000077185:Resveratrol
keywords: ABCG1; ATPase activity; Proteoliposome; Saccharomyces cerevisiae