title: Tumor targeting by a carbohydrate ligand-mimicking peptide.
abstract: Annexin A1 (Anxa1) is a highly specific surface marker of tumor vasculature. We used peptide-displaying phage technology to identify a carbohydrate ligand-mimicking 7-mer peptide, IFLLWQR (IF7), which can target Anxa1 in tumor vasculature. Here, we describe the binding activity of carbohydrate to Anxa1, Anxa1 to heparan sulfates, and the therapeutic potential of IF7 conjugated with anticancer drugs in tumor targeting.
authors.affiliation: Department of Urology, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Hatakeyama
authors.forename: Toshiaki K
authors.initials: TK
authors.lastname: Shibata
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tobisawa
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohyama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugihara
authors.forename: Michiko N
authors.initials: MN
authors.lastname: Fukuda
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017305:Annexin A1 / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry; D006497:Heparan Sulfate / Q000378:metabolism; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D017305:Annexin A1; D000970:Antineoplastic Agents; D002241:Carbohydrates; D005456:Fluorescent Dyes; D006497:Heparan Sulfate; D010455:Peptides