title: Comparison of UW and Celsior: long-term results in kidney transplantation.
abstract: BACKGROUND
  The aim of this study was to compare 2 preservation solutions in kidney transplant recipients in the same center during the same period since initiation of the use of High Na+; low K+ solution (Celsior).
  
  
  METHODS
  From January 1999 to April 2011, 610 consecutive renal transplantations were done in our department with deceased donor kidneys. Data were collected prospectively. Organ procurement was performed in our center for 305 kidneys. We washed and preserved 409 kidneys in UW, and 201 in Celsior solution.
  
  
  RESULTS
  Donors criteria were worse in the Celsior group for age, male sex, creatinemia, and cold ischemia. Populations of recipients were comparable. There were no differences at 1 and 12 months in creatinine levels (p=0.9 and 0.8, respectively) and in number of delayed graft functions (DGF) (p=0.8 and relative risk =0.9) between groups. There were no differences in post-transplantation outcomes for all variables. At 5 years, graft survival was 90.4% for UW and 93.5% for Celsior (p=0.44).
  
  
  CONCLUSIONS
  Our retrospective study did not succeed in demonstrating superiority of a High Na+; low K+ solution compared to a UW type reference solution. Celsior has the same effectiveness as UW during kidney cold storage.
authors.affiliation: Department of Urology and Transplantation, University Hospital, Amiens, France. xavtillou@hotmail.com
authors.forename: Xavier
authors.initials: X
authors.lastname: Tillou
authors.forename: Sylvie
authors.initials: S
authors.lastname: Collon
authors.forename: Nicolas
authors.initials: N
authors.lastname: Surga
authors.forename: Maité
authors.initials: M
authors.lastname: Jaureguy
authors.forename: Ludovic
authors.initials: L
authors.lastname: Viart
authors.forename: Hakim
authors.initials: H
authors.lastname: Mazouz
authors.forename: Marc
authors.initials: M
authors.lastname: Gigante
mesh_terms: D000241:Adenosine / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000009:adverse effects; D051799:Delayed Graft Function / Q000209:etiology; D004187:Disaccharides / Q000009:adverse effects; D004573:Electrolytes / Q000009:adverse effects; D005260:Female; D005602:France / Q000453:epidemiology; D005971:Glutamates / Q000009:adverse effects; D005978:Glutathione / Q000009:adverse effects; D006085:Graft Survival; D006639:Histidine / Q000009:adverse effects; D006801:Humans; D007328:Insulin / Q000009:adverse effects; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D008297:Male; D008353:Mannitol / Q000009:adverse effects; D008875:Middle Aged; D019188:Organ Preservation Solutions / Q000009:adverse effects; D011446:Prospective Studies; D011887:Raffinose / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose