title: The pro-oxidant effect of angiotensin-1 converting enzyme in Tunisian patients with coronary heart disease.
abstract: BACKGROUND
  Evaluation and investigation of the pro-oxidant role of the angiotensin-1 converting enzyme among Tunisian coronary.
  
  
  METHODS
  In the present study the angiotensin-1 converting enzyme (ACE1) was determined by a kinetic method for coronary and witness populations. These subjects (117 patients and 86 controls) beneficed also by an enzymatic determination of superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS) to reveal the atherogenic effects of these radical species and investigate their interactions with ACE1. RESULTS. The determination of ACE1 activity showed a significant increase in patients compared to controls (82.24 +/- 21.6 vs 49.23 +/- 12.85 UI/L, p <0.000001). Statistical tests have shown negative correlations between the ACE 1 activity and the antioxidant defense markers (SOD, GPx and TAS).
  
  
  CONCLUSIONS
  In addition to its vasoconstrictor role, ACE1 can be considered as a pro-oxidant enzyme, these two effects combine in the genesis and the complications of cardiovascular diseases. (www.actabiomedica.it)
authors.affiliation: Laboratory of Biochemistry Farhat Hached Hospital, Sousse, Tunisia. gaddour83@yahoo.fr
authors.forename: Abdelkader
authors.initials: A
authors.lastname: Chalghoum
authors.forename: Yosri
authors.initials: Y
authors.lastname: Noichri
authors.forename: Manel Hadj
authors.initials: MH
authors.lastname: Mohamed
authors.forename: Azza
authors.initials: A
authors.lastname: Dandana
authors.forename: Bruno
authors.initials: B
authors.lastname: Baudin
authors.forename: Salima
authors.initials: S
authors.lastname: Ferchichi
authors.forename: Abdelhédi
authors.initials: A
authors.lastname: Miled
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D003327:Coronary Disease / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011446:Prospective Studies; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000378:metabolism; D014416:Tunisia
chemical_list: D015415:Biomarkers; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D007703:Peptidyl-Dipeptidase A