title: Nuclear factor of activated T cells - a transcription factor family as critical regulator in lung and colon cancer.
abstract: Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor which is activated upon T cell stimulation. Subsequent studies uncovered that a whole family of individual NFAT proteins exists with pleiotropic functions not only in immune but also in nonimmune cells. However, dysregulation of NFAT thereby favors malignant growth and cancer. Summarizing the recent advances in understanding how individual NFAT factors regulate the immune system, this review gives new insights into the critical role of NFAT in cancer development with special focus on inflammation-associated colorectal cancer.
authors.affiliation: Institute of Diabetes Research, Helmholtz Zentrum Muenchen,German Research Center for Environmental Health (GmbH), Munich, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Daniel
authors.forename: Katharina
authors.initials: K
authors.lastname: Gerlach
authors.forename: Martin
authors.initials: M
authors.lastname: Väth
authors.forename: Markus F
authors.initials: MF
authors.lastname: Neurath
authors.forename: Benno
authors.initials: B
authors.lastname: Weigmann
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism*; D004789:Enzyme Activation / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008175:Lung Neoplasms / Q000378:metabolism*; D050778:NFATC Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D050778:NFATC Transcription Factors
keywords: cancer; nuclear factor of activated T cells; transcription factor