title: Hepatoprotective and antioxidant capacity of Melochia corchorifolia extracts.
abstract: OBJECTIVE
  To evaluate hepato protective and antioxidant capacity of Melochia corchorifolia (M. corchorifolia) aerial part extracts.
  
  
  METHODS
  Antioxidant activity was evaluated by using three free radicals (Superoxide, Hydroxyl and DPPH) and hepatoprotective activity was assessed against CCl4 induced liver intoxication in rats.
  
  
  RESULTS
  The extracts produced concentration dependent percentage protection in decrease of serum enzymes and percentage inhibition on free radicals. Among all extracts methanol extract showed better activity with percentage protection of SGOT (78.98%), SGPT (79.65%), ALP (82.48%) and total bilirubin (80.0%) levels against CCl4 liver intoxication and also methanolic extract showed better activity with IC50 values on superoxide, hydroxyl and DPPH radicals were 127 μ g, 240 μ g and 179 μ g.
  
  
  CONCLUSIONS
  From the results obtained during the study it could be concluded that M. corchorifolia aerial part extracts have antioxidant and hepatoprotective components. Further study is necessary for isolation and characterization of bioactive molecules which are responsible for hepatoprotective and antioxidant activity.
authors.affiliation: A.U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India-530003.
authors.forename: B Ganga
authors.initials: BG
authors.lastname: Rao
authors.forename: Y Venkateswara
authors.initials: YV
authors.lastname: Rao
authors.forename: T Mallikarjuna
authors.initials: TM
authors.lastname: Rao
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D017665:Hydroxyl Radical / Q000378:metabolism; D020128:Inhibitory Concentration 50; D008297:Male; D019660:Malvaceae; D010636:Phenols / Q000302:isolation & purification; D008517:Phytotherapy / Q000379:methods*; D010851:Picrates / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013481:Superoxides / Q000378:metabolism
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D001713:Biphenyl Compounds; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D013481:Superoxides; D017665:Hydroxyl Radical; D002251:Carbon Tetrachloride; C004931:1,1-diphenyl-2-picrylhydrazyl