title: Gold meets rhodium: tandem one-pot synthesis of β-disubstituted ketones via Meyer-Schuster rearrangement and asymmetric 1,4-addition.
abstract: An asymmetric one-pot tandem Au/Rh-catalyzed synthesis of highly enantioenriched β-disubstituted ketones starting from racemic propargyl alcohols is disclosed. The compatibility of the two metal complexes (Au/Rh) and their orthogonal ligand systems (NHC/diene) in this bimetallic catalytic system is investigated.
authors.affiliation: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
authors.forename: Max M
authors.initials: MM
authors.lastname: Hansmann
authors.forename: A Stephen K
authors.initials: AS
authors.lastname: Hashmi
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D056831:Coordination Complexes; D007659:Ketones; D008024:Ligands; D020005:Propanols; D006046:Gold; D012238:Rhodium; C028255:propargyl alcohol