title: Amyloidogenic peptide homologous to fragment 129-148 of human myocilin.
abstract: Myocilin is a protein with a molecular weight near 50 kDa. It is expressed in almost all organs and tissues. We showed that the peptide DQLETQTRELETAYSNLLRD corresponding to N-terminal Leucine zipper motif (LZM) of the protein is able to form amyloid-like fibrils. The possible role of this motif in myocilin aggregation is discussed.
authors.affiliation: Research Institute of Influenza, Ministry of Healthcare of the Russian Federation, St. Petersburg, Russia. toizeg@gmail.com
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Egorov
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Grudinina
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Lebedev
authors.forename: Aram A
authors.initials: AA
authors.lastname: Shaldzhyan
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Slita
authors.forename: Alexey K
authors.initials: AK
authors.lastname: Sirotkin
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Vasin
authors.forename: Michael M
authors.initials: MM
authors.lastname: Shavlovsky
mesh_terms: D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D005136:Eye Proteins / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D006023:Glycoproteins / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D016350:Leucine Zippers; D008969:Molecular Sequence Data; D000099179:Myocilin
chemical_list: D000682:Amyloid; D003598:Cytoskeletal Proteins; D005136:Eye Proteins; D006023:Glycoproteins; D000099179:Myocilin
keywords: fibrillogenesis; leucine zipper motif; myocilin