title: Primary stability of a PGLA/Polydioxanone membrane for potential autologous chondrocyte implantation in the hip joint. A cadaveric study.
abstract: The purpose of this cadaveric study was to evaluate the primary stability of a membrane  (resorbable polyglactin-910/poly-p-dioxanone) for autologous chondrocyte implantation (ACI) inserted by press-fit into defects in the femoral head and acetabulum. The stability of the membrane was evaluated after implantation in a cartilage defect on both sides of the joint in 12 hips in six cadavers. The hip was manually put through a full range of motion for 50 cycles after each lesion had been created and filled, starting with the acetabulum. The implanted membranes showed stability in 83.3% of the acetabular defects and in 33.3% of the femoral defects after the 50 cycles. After an additional 50 cycles the acetabular membrane showed stability in a total of eight (67%) out of 12 acetabular lesions. The results indicate that this membrane tissue is potentially stable in cartilage defects of the acetabulum, which may have clinical applications in autologous chondrocyte implantation.
authors.affiliation: Orthopaedics 1, COF Lanzo Hospital, Lanzo d'Intelvi, Como, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Fontana
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bistolfi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Crova
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Massazza
mesh_terms: D000368:Aged; D023181:Antimicrobial Cationic Peptides; D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D002102:Cadaver; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D006621:Hip Joint / Q000601:surgery*; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D016687:Polydioxanone; D011474:Prosthesis Design; D013499:Surface Properties; D014182:Transplantation, Autologous
chemical_list: D023181:Antimicrobial Cationic Peptides; C045866:peptide-Gly-Leu-amide; D016687:Polydioxanone