title: Suppression of interferon-mediated antiviral immunity by hepatitis B virus: an overview of research progress.
abstract: Interferon (IFN)-α is an indispensable drug for hepatitis B treatment in clinical settings. However, hepatitis B virus (HBV) can attenuate IFN-mediated antiviral responses to avoid being inhibited or cleared. Much progress has been made in exploring how the IFN-induced anti-HBV effect is inhibited. This review examines and summarizes new advances regarding the molecular mechanism underlying the HBV-induced suppression of type I IFN-mediated antiviral immunity.
authors.affiliation: West Campus Hospital of Shandong University, Jinan, China.
authors.forename: P
authors.initials: P
authors.lastname: Guo
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006509:Hepatitis B / Q000188:drug therapy* / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D016898:Interferon-alpha / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D016899:Interferon-beta / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D016899:Interferon-beta