title: Cytotoxic dibenzocyclooctadiene lignans from Kadsura coccinea.
abstract: Three new dibenzocyclooctadiene lignans, kadusurain A-C (1-3), together with two known compounds kadsuphilin A (4) and B (5), were isolated from an EtOAc fraction of the 80 % acetone extract of Kadsura coccinea (Lem.) A. C. Smith. Their structures were established by 1D and 2D NMR techniques, and mass spectroscopy. Anti-proliferative effect of isolated compounds was evaluated against four human tumor cell lines (A549, HCT116, HL-60, and HepG2), and it was found that compound 1 exhibited significant antiproliferative effects with IC50 values ranging from 1.05 to 12.56 μg/ml.
authors.affiliation: Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China, qjzhao@smmu.edu.cn.
authors.forename: Qing-Jie
authors.initials: QJ
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Hai-Sheng
authors.initials: HS
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D018929:Cell Culture Techniques; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D034242:Cyclooctanes / Q000302:isolation & purification / Q000494:pharmacology*; D045325:HCT116 Cells; D018922:HL-60 Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D034242:Cyclooctanes; D017705:Lignans; C510994:dibenzocyclooctadiene lignan