title: Alternative methods for the screening of retinopathy of prematurity: binocular indirect ophthalmoscopy vs wide-field digital retinal imaging.
abstract: OBJECTIVE
  To compare the diagnostic efficacy of wide-field digital retinal imaging (WFDRI) with binocular indirect ophthalmoscopy (BIO) for retinopathy of prematurity (ROP) screening.
  
  
  METHODS
  Premature infants admitted for ROP screening were included in this prospective, randomized and double-blind comparative study. They were examined by using BIO and WFDRI.
  
  
  RESULTS
  A total of 58 infants were enrolled in the study. The sensitivities of WFDRI in detecting any stage of ROP, treatment-requiring ROP and plus disease were 58.6, 100, and 100% respectively, with a specificity of 100% for all. The proportional agreement between WFDRI and BIO was 0.903 for detection of any stage of ROP, 1.0 for treatment-requiring ROP, and 1.0 for plus disease.
  
  
  CONCLUSIONS
  The sensitivity and specificity of WFDRI was excellent for the diagnosis of severe and treatment-requiring ROP. However, BIO was superior in mild ROP particularly for the ones in retinal periphery.
authors.affiliation: ROP Screening, Treatment and Training Center, Department of Ophthalmology, Etlik Zubeyde Hanim Maternity and Women's Health Research Hospital, Ankara, Turkey.
authors.forename: M A
authors.initials: MA
authors.lastname: Sekeroglu
authors.forename: E
authors.initials: E
authors.lastname: Hekimoglu
authors.forename: H T
authors.initials: HT
authors.lastname: Sekeroglu
authors.forename: U
authors.initials: U
authors.lastname: Arslan
mesh_terms: D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D009887:Ophthalmoscopy / Q000379:methods*; D010781:Photography; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000175:diagnosis*; D012680:Sensitivity and Specificity