title: Carving axon arbors to fit: master directs one kinase at a time.
abstract: Pyramidal neurons in the cortex require the master kinase LKB1 for early axon specification. Courchet et al. now uncover a later role for LKB1 and its tango with the downstream effector kinase NUAK1 in controlling terminal axonal branching through influencing mitochondrial motility in axons.
authors.affiliation: Biozentrum, University of Basel, 4056 Basel, Switzerland.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Satoh
authors.forename: Silvia
authors.initials: S
authors.lastname: Arber
mesh_terms: D055372:AMP-Activated Protein Kinases; D000818:Animals; D001369:Axons / Q000378:metabolism*; D005260:Female; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D009474:Neurons / Q000166:cytology*; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D012097:Repressor Proteins; D011494:Protein Kinases; C571903:NUAK1 protein, mouse; D017346:Protein Serine-Threonine Kinases; C491654:Stk11 protein, mouse; D055372:AMP-Activated Protein Kinases