title: Visual loss from scleritis in C-ANCA-positive microscopic polyangiitis.
abstract: Scleritis is an inflammation of the outer eye coating that manifests with redness and ocular pain, and tends to be more severe when associated with a systemic collagen disease. Antineutrophil cytoplasmic antibody (ANCA)-positive microscopic polyangiitis is an autoimmune, multisystem, chronic disease characterised by damage to the endothelial lining of small vessels, and can be associated with severe scleritis that necessitates early aggressive therapy to prevent severe ocular complications.
authors.affiliation: Princess Margaret Cancer Centre, Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada.
authors.forename: Salah
authors.initials: S
authors.lastname: Alrashidi
authors.forename: Yacoub A
authors.initials: YA
authors.lastname: Yousef
authors.forename: Hatem
authors.initials: H
authors.lastname: Krema
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D055953:Microscopic Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D015423:Scleritis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D014786:Vision Disorders / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D014792:Visual Acuity
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D011239:Prednisolone; D001379:Azathioprine