title: Osteoarthritis year in review 2013: biology.
abstract: The purpose of this review was to present highlights from the published literature on the topic of the biology of osteoarthritis (OA). A PubMed search was conducted in order to locate original research manuscripts published since the last OARSI meeting in 2012. From review of the published literature, common themes emerged as active areas of research over the past year including studies in the areas of epigenetics, Wnt signaling, the role of inflammatory pathways in OA, lubricin, fibroblast growth factor signaling, and studies on OA biology in bone. Key findings in these areas were summarized and implications for future therapies were discussed.
authors.affiliation: Department of Internal Medicine, Section of Molecular Medicine and The Wake Forest Arthritis and Musculoskeletal Diseases Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: rloeser@wakehealth.edu.
authors.forename: R F
authors.initials: RF
authors.lastname: Loeser
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000235:genetics / Q000503:physiopathology; D001842:Bone and Bones / Q000503:physiopathology; D057890:Epigenomics; D005346:Fibroblast Growth Factors / Q000502:physiology; D006023:Glycoproteins / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D010003:Osteoarthritis / Q000235:genetics / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology; D060449:Wnt Signaling Pathway / Q000502:physiology; D000099158:Proteoglycan 4
chemical_list: D005346:Fibroblast Growth Factors; D006023:Glycoproteins; D018836:Inflammation Mediators; D000099158:Proteoglycan 4
keywords: Bone; Cartilage; Growth factors; Inflammation; Meniscus; Signaling; Synovium