title: Performance status in elderly patients with acute myeloid leukemia: exploring gene expression signatures of cytokines and chemokines.
abstract: Acute myeloid leukemia (AML) is an aggressive disease that predominantly affects elderly patients. Cytokines and chemokines are major players in the pathogenesis of AML. They regulate the disease course and play a deleterious role in the progression of AML. The geriatric population is particularly vulnerable to these mediators as these cytokines and chemokines are also implicated in the development of frailty, fatigue, and declining cognitive function. It is the combination of these adverse effects of cytokines and chemokines that affect performance status and, in turn, the poor prognosis in this age group. Cytokines and chemokines are emerging as therapeutic targets in AML. Future endeavors to treat AML will likely involve cytokines and chemokines as attempts are made to disrupt the bone marrow environment. By modulating the bone marrow stroma, the goal is to create an environment less favorable to AML cells and more favorable to the effects of chemotherapy against AML.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Nipp
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina. arati.rao@dm.duke.edu.
authors.forename: Arati V
authors.initials: AV
authors.lastname: Rao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018925:Chemokines / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology*; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology; D016207:Cytokines / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology*; D005221:Fatigue / Q000209:etiology; D016330:Frail Elderly; D015870:Gene Expression; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000378:metabolism*; D011788:Quality of Life
chemical_list: D018925:Chemokines; D016207:Cytokines