title: [Pineal hormone melatonin in low doses potentiates psychotropic and chronotropic activity of tofisopam in rats].
abstract: Combination with a low dose of pineal hormone melatonin increased the anxiolytic effect of tofisopam (subthreshold dose) in open-field and cross-maze tests, as well as its chronotropic activity in time-course of forced swimming test in rats.
authors.forename: É B
authors.initials: ÉB
authors.lastname: Abrushanian
authors.forename: A V
authors.initials: AV
authors.lastname: Popov
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000819:agonists / Q000494:pharmacology; D001569:Benzodiazepines / Q000819:agonists / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000819:agonists / Q000494:pharmacology; D054313:Drug Agonism; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008550:Melatonin / Q000819:agonists / Q000494:pharmacology; D010870:Pineal Gland / Q000378:metabolism; D051381:Rats
chemical_list: D000928:Antidepressive Agents; D002492:Central Nervous System Depressants; D001569:Benzodiazepines; D008550:Melatonin; C012582:tofisopam