title: A messenger at the door: cytomegalovirus retinitis in myeloma patients with progressive disease.
abstract: Cytomegalovirus (CMV) retinitis is an uncommon manifestation of CMV disease and is a marker of severe and profound immunosuppression in human immunodeficiency virus-positive patients. Here, we describe 2 cases of CMV retinitis in myeloma patients with progressive disease, following autologous stem cell transplantation and immunomodulatory therapy for myeloma. To our knowledge, this is the first report of CMV retinitis in this patient population. This report illustrates the need for close monitoring of relapsed and refractory myeloma patients for new presentations of opportunistic infections secondary to severe immunosuppression.
authors.affiliation: Department of Infectious Diseases and Infection Control, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. ben.teh@petermac.org
authors.forename: B W
authors.initials: BW
authors.lastname: Teh
authors.forename: A S
authors.initials: AS
authors.lastname: Khot
authors.forename: S J
authors.initials: SJ
authors.lastname: Harrison
authors.forename: H M
authors.initials: HM
authors.lastname: Prince
authors.forename: M A
authors.initials: MA
authors.lastname: Slavin
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D017726:Cytomegalovirus Retinitis / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D003907:Dexamethasone / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D015774:Ganciclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D000077562:Valganciclovir
chemical_list: D000998:Antiviral Agents; D003907:Dexamethasone; D000077562:Valganciclovir; D015774:Ganciclovir
keywords: CMV; myeloma; retinitis