title: Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (Annonaceae).
abstract: The aim of this study was to investigate the chemical composition and anticancer effect of the leaf essential oil of Xylopia frutescens in experimental models. The chemical composition of the essential oil was analysed by GC/FID and GC/MS. In vitro cytotoxic activity of the essential oil was determined on cultured tumour cells. In vivo antitumour activity was assessed in Sarcoma 180-bearing mice. The major compounds identified were (E)-caryophyllene (31.48%), bicyclogermacrene (15.13%), germacrene D (9.66%), δ-cadinene (5.44%), viridiflorene (5.09%) and α-copaene (4.35%). In vitro study of the essential oil displayed cytotoxicity on tumour cell lines and showed IC50 values ranging from 24.6 to 40.0 μg/ml for the NCI-H358M and PC-3M cell lines, respectively. In the in vivo antitumour study, tumour growth inhibition rates were 31.0-37.5%. In summary, the essential oil was dominated by sesquiterpene constituents and has some interesting anticancer activity.
authors.affiliation: Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
authors.forename: Rosana P C
authors.initials: RP
authors.lastname: Ferraz
authors.forename: Gabriella M B
authors.initials: GM
authors.lastname: Cardoso
authors.forename: Thanany B
authors.initials: TB
authors.lastname: da Silva
authors.forename: José Eraldo do N
authors.initials: JE
authors.lastname: Fontes
authors.forename: Ana Paula do N
authors.initials: AP
authors.lastname: Prata
authors.forename: Adriana A
authors.initials: AA
authors.lastname: Carvalho
authors.forename: Manoel O
authors.initials: MO
authors.lastname: Moraes
authors.forename: Claudia
authors.initials: C
authors.lastname: Pessoa
authors.forename: Emmanoel V
authors.initials: EV
authors.lastname: Costa
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Bezerra
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000008:administration & dosage* / Q000737:chemistry; D054336:Xylopia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile; D010938:Plant Oils