title: Bortezomib and heart failure: case-report and review of the French Pharmacovigilance database.
abstract: Bortezomib is a proteasome inhibitor commonly indicated for the treatment of multiple myeloma and non Hodgkin lymphoma. Cardiac adverse drug reactions of this drug are not clearly established. We report case where direct involvement of bortezomib in the occurrence of heart failure is strongly suspected and 22 other cases spontaneously reported to the French Pharmacovigilance System. This report should increase cardiologist awareness about the risk of heart failure related to this drug. Moreover, these cases underline the need for a systematic cardiac screening in patients exposed to bortezomib.
authors.affiliation: Centre Hospitalier et Universitaire de Toulouse, Service de Cardiologie, F-31432, Toulouse, France; Institut National de la Santé et de la Recherche Médicale INSERM, Institut des Maladies Métaboliques et cardiovasculaires I2MC, Université de Toulouse, UPS, F-31432, Toulouse, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Honton
authors.forename: Fabien
authors.initials: F
authors.lastname: Despas
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dumonteil
authors.forename: Caroline
authors.initials: C
authors.lastname: Rouvellat
authors.forename: Murielle
authors.initials: M
authors.lastname: Roussel
authors.forename: Didier
authors.initials: D
authors.lastname: Carrie
authors.forename: Michel
authors.initials: M
authors.lastname: Galinier
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Montastruc
authors.forename: Atul
authors.initials: A
authors.lastname: Pathak
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001897:Boronic Acids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000069286:Bortezomib; D062313:Databases, Pharmaceutical; D005602:France; D006333:Heart Failure / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy; D060735:Pharmacovigilance; D011719:Pyrazines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib
keywords: bortezomib; heart failure; pharmacovigilance