title: [Treatment of superficial infantile hemangiomas with topical propranolol].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of 1% propranolol ointment in the treatment of superficial infantile hemangiomas (IHs).
  
  
  METHODS
  A retrospective chart review was performed on 49 children (34 female and 15 male) with a median age of 4.1 months (range, 1-10 months). A total of 58 superficial IHs were treated with 1% propranolol ointment. Topical propranolol was applied three times daily for a mean duration of 21.1 weeks (range, 5-59 weeks). Changes in the size, texture, and color of the tumor were monitored and recorded at regular intervals. The treatment response was evaluated using a 3-point scale system: good, partial, and no response. Adverse effects after medication were evaluated and managed accordingly.
  
  
  RESULTS
  Of the 49 cases, 26 (53.1%) demonstrated good response, 17 (34.7%) showed a partial response, and 6 (12.2%) had no response. The total effective rate was 87.8% . No systemic complication was observed in any of the patients.
  
  
  CONCLUSIONS
  Topical therapy with 1% propranolol ointment may be a safe and effective method for the treatment of superficial IHs and can be used as an adjuvant treatment measure during the wait-and-see period.
authors.affiliation: Department of Aesthetic, Plastic, and Burn Surgery, Shandong Provincial Hospital, Jinan 250021, China.
authors.forename: Jing-Ning
authors.initials: JN
authors.lastname: Niu
authors.forename: Guang-Qi
authors.initials: GQ
authors.lastname: Xu
authors.forename: Ren-Rong
authors.initials: RR
authors.lastname: Lü
authors.forename: Ran
authors.initials: R
authors.lastname: Huo
mesh_terms: D005260:Female; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D009824:Ointments; D011433:Propranolol / Q000008:administration & dosage* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D009824:Ointments; D011433:Propranolol