title: Campanula portenschlagiana ROEM. et SCHULT.: chemical and antimicrobial activities.
abstract: The phytochemical profile and the antimicrobial effects of the volatile oil and the aqueous extract of Campanula portenschlagiana, a wild growing plant endemic to Croatia, were described. In the volatile oil, 53 compounds were identified by GC-FID and GC/MS analyses. Diterpene alcohols constituted the major compound class with labda-13(16),14-dien-8-ol as the main compound. The aqueous extract was characterized by the total phenolic content. The antimicrobial potential of the volatile oil and the aqueous extract was evaluated against a diverse range of microorganisms comprising food-spoilage and food-borne pathogens. The volatile oil exhibited interesting and promising antimicrobial effects against the tested species, which were generally more pronounced against Gram-negative bacteria. In addition, the inhibitory effect of this volatile oil was also evaluated against eleven extended-spectrum β-lactamase (ESBL)-producing isolates. The results suggest that the C. portenschlagiana volatile oil might be used as antimicrobial agent against ESBL-producing isolates and Gram-negative bacteria.
authors.affiliation: Department of Biochemistry, Faculty of Chemistry and Technology, University of Split, N. Tesle 10/V, HR-21000 Split, Croatia. olivera@ktf-split.hr
authors.forename: Olivera
authors.initials: O
authors.lastname: Politeo
authors.forename: Mirjana
authors.initials: M
authors.lastname: Skocibusic
authors.forename: Franko
authors.initials: F
authors.lastname: Burcul
authors.forename: Ana
authors.initials: A
authors.lastname: Maravic
authors.forename: Ivana
authors.initials: I
authors.lastname: Carev
authors.forename: Mirko
authors.initials: M
authors.lastname: Ruscic
authors.forename: Mladen
authors.initials: M
authors.lastname: Milos
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029422:Campanulaceae / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D009822:Oils, Volatile; D001618:beta-Lactamases