title: A library of multifunctional polyesters with "peptide-like" pendant functional groups.
abstract: The synthesis and characterization of a library of modular multifunctional polyesters with pendant functional groups are described. The polyesters were synthesized at room temperature by carbodiimide-mediated polymerization of pendant functionalized diols and succinic acid. The pendant groups are designed to mimic the side chains of peptides, and it is shown that the physical properties of the polyesters can be modulated over a wide range by the choice of pendant groups. We also show that the pendant groups can be orthogonally functionalized with ligands such as fluorophores, poly(ethylene glycol) (PEG) or Arg-Gly-Asp (RGD).
authors.affiliation: Department of Polymer Science, The University of Akron, Ohio 44325, USA.
authors.forename: Sachin
authors.initials: S
authors.lastname: Gokhale
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.forename: Abraham
authors.initials: A
authors.lastname: Joy
mesh_terms: D020341:Absorbable Implants; D000595:Amino Acid Sequence; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D061565:Cycloaddition Reaction; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D009842:Oligopeptides; D011091:Polyesters; D054852:Small Molecule Libraries; D011092:Polyethylene Glycols; C047981:arginyl-glycyl-aspartic acid; D016650:Fluorescein-5-isothiocyanate