title: Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects.
abstract: BACKGROUND
  The presence of morphometric abnormalities of the lateral ventricles, which can reflect focal or diffuse atrophic changes of nearby brain structures, is not well characterized in methamphetamine dependence. The current study was aimed to examine the size and shape alterations of the lateral ventricles in methamphetamine-dependent subjects.
  
  
  METHODS
  High-resolution brain structural images were obtained from 37 methamphetamine-dependent subjects and 25 demographically matched healthy individuals. Using a combined volumetric and surface-based morphometric approach, the structural variability of the lateral ventricles, with respect to extent and location, was examined.
  
  
  RESULTS
  Methamphetamine-dependent subjects had an enlarged right lateral ventricle compared with healthy individuals. Morphometric analysis revealed a region-specific pattern of lateral ventricular expansion associated with methamphetamine dependence, which was mainly distributed in the areas adjacent to the ventral striatum, medial prefrontal cortex, and thalamus.
  
  
  CONCLUSIONS
  Patterns of shape decomposition in the lateral ventricles may have relevance to the structural vulnerability of the prefrontal-ventral striatal-thalamic circuit to methamphetamine-induced neurotoxicity.
authors.affiliation: Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences, 103 Daehak-ro, Jongno-gu, Seoul 110-799, South Korea.
authors.forename: Hyeonseok S
authors.initials: HS
authors.lastname: Jeong
authors.forename: Sunho
authors.initials: S
authors.lastname: Lee
authors.forename: Sujung
authors.initials: S
authors.lastname: Yoon
authors.forename: Jiyoung J
authors.initials: JJ
authors.lastname: Jung
authors.forename: Han Byul
authors.initials: HB
authors.lastname: Cho
authors.forename: Binna N
authors.initials: BN
authors.lastname: Kim
authors.forename: Jiyoung
authors.initials: J
authors.lastname: Ma
authors.forename: Eun
authors.initials: E
authors.lastname: Ko
authors.forename: Jooyeon Jamie
authors.initials: JJ
authors.lastname: Im
authors.forename: Soonhyun
authors.initials: S
authors.lastname: Ban
authors.forename: Perry F
authors.initials: PF
authors.lastname: Renshaw
authors.forename: In Kyoon
authors.initials: IK
authors.lastname: Lyoo
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D020547:Lateral Ventricles / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008694:Methamphetamine; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology; D009929:Organ Size; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D008694:Methamphetamine
keywords: Lateral ventricle; Methamphetamine; Neuroimaging; Surface-based morphometry