title: Intractable diarrhoea caused by cytomegalovirus enterocolitis in an immunocompetent term neonate.
abstract: Symptomatic cytomegalovirus (CMV) infection mainly affects preterm and immunocompromised infants and usually manifest as rash, pneumonia, hepatospleenomegaly or encephalitis. To our knowledge intractable diarrhoea at two weeks of age caused by postnatally acquired CMV in immunocompetent term neonate is not reported. An unusual case of postnatally acquired CMV enterocolitis manifesting as protracted diarrhoea in an immunocompetent baby in neonatal period is reported. We conclude that CMV should be considered in the differential diagnosis of intractable diarrhoea in neonatal period and treatment with intravenous ganciclovir for CMV enterocolitis is not only indicated but is therapeutic.
authors.affiliation: Department of Pediatrics, PGIMER & Dr RML Hospital, New Delhi 110001, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Gupta
authors.forename: Arti
authors.initials: A
authors.lastname: Maria
authors.forename: Deepak
authors.initials: D
authors.lastname: Goyal
authors.forename: Arushi
authors.initials: A
authors.lastname: Verma
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D003967:Diarrhea / Q000175:diagnosis / Q000209:etiology*; D020776:Endoscopes, Gastrointestinal; D004760:Enterocolitis / Q000188:drug therapy / Q000821:virology*; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007121:Immunocompetence; D007075:Immunoglobulin M; D007231:Infant, Newborn; D016133:Polymerase Chain Reaction; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D007075:Immunoglobulin M; D015774:Ganciclovir
keywords: cytomegalovirus; diarrhoea; ganciclovir; neonate