title: Severe toxic hepatitis associated with dronedarone.
abstract: Dronedarone was introduced in 2009 as a new antiarrhythmic agent and since then has been increasingly prescribed in atrial fibrillation or flutter. To date, two cases of severe toxic hepatitis have been reported in patients treated with dronedarone, both requiring emergency liver transplantation, and the FDA as well as the EMA have issued warnings about possible severe hepatotoxicity of dronedarone. Here we report an additional case of toxic hepatitis associated with dronedarone presenting with acute liver failure, followed by spontaneous recovery, in a 69-year old woman.
authors.affiliation: Institute of Pathology, Medical University of Graz, Graz, Austria.
authors.forename: Stephan
authors.initials: S
authors.lastname: Jahn
authors.forename: Gernot
authors.initials: G
authors.lastname: Zollner
authors.forename: Carolin
authors.initials: C
authors.lastname: Lackner
authors.forename: Rudolf E
authors.initials: RE
authors.lastname: Stauber
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000209:etiology* / Q000503:physiopathology; D000077764:Dronedarone; D005260:Female; D006801:Humans; D012720:Severity of Illness Index
chemical_list: D000889:Anti-Arrhythmia Agents; D000077764:Dronedarone; D000638:Amiodarone