title: Tumor-derived vascular pericytes anergize Th cells.
abstract: Immune evasion within the tumor microenvironment supports malignant growth and is also a major obstacle for successful immunotherapy. Multiple cellular components and soluble factors coordinate to disrupt protective immune responses. Although stromal cells are well-known for their parenchymal supportive roles in cancer establishment and progression, we demonstrate for the first time, to our knowledge, that tumor-derived vascular pericytes negatively influence CD4(+) T cell activation and proliferation, and promote anergy in recall response to Ag by CD4(+)CD44(+) T cells via regulator of G protein signaling 5- and IL-6-dependent pathways. Our data support a new specific role for tumor-derived pericytes in the immune evasion paradigm within the tumor microenvironment and suggest the targeting of these cell populations in the context of successful immunotherapeutics for the treatment of cancer.
authors.affiliation: Department of Molecular Medicine, Bose Institute, Kolkata 700054, India. anamikabose2@gmail.com
authors.forename: Anamika
authors.initials: A
authors.lastname: Bose
authors.forename: Subhasis
authors.initials: S
authors.lastname: Barik
authors.forename: Saptak
authors.initials: S
authors.lastname: Banerjee
authors.forename: Tithi
authors.initials: T
authors.lastname: Ghosh
authors.forename: Atanu
authors.initials: A
authors.lastname: Mallick
authors.forename: Suchandra
authors.initials: S
authors.lastname: Bhattacharyya Majumdar
authors.forename: Kuntal Kanti
authors.initials: KK
authors.lastname: Goswami
authors.forename: Avishek
authors.initials: A
authors.lastname: Bhuniya
authors.forename: Sayantan
authors.initials: S
authors.lastname: Banerjee
authors.forename: Rathindranath
authors.initials: R
authors.lastname: Baral
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Storkus
authors.forename: Partha Sarathi
authors.initials: PS
authors.lastname: Dasgupta
authors.forename: Subrata
authors.initials: S
authors.lastname: Majumdar
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D049109:Cell Proliferation; D018925:Chemokines / Q000378:metabolism; D017635:Clonal Anergy / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D019204:GTP-Binding Proteins / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D018960:Hyaluronan Receptors / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000276:immunology*; D020286:Pericytes / Q000378:metabolism*; D020710:RGS Proteins / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering; D019139:Tumor Escape; D059016:Tumor Microenvironment / Q000276:immunology
chemical_list: D018925:Chemokines; D000949:Histocompatibility Antigens Class II; D018960:Hyaluronan Receptors; D015850:Interleukin-6; D020710:RGS Proteins; D034741:RNA, Small Interfering; C105346:Rgs5 protein, mouse; C514992:VCC-1 protein, mouse; D018799:Intercellular Adhesion Molecule-1; D019204:GTP-Binding Proteins