title: One-pot synthesis of quinazoline derivatives via [2+2+2] cascade annulation of diaryliodonium salts and two nitriles.
abstract: An efficient one-pot approach to multiple substituted quinazolines with diaryliodonium salt , and two nitriles has been presented. The reaction enables great flexibility of the substitution patterns on quinazolines and is applicable to two different nitriles to give a regio-selective product.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Su
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Junjie
authors.initials: J
authors.lastname: Chen
authors.forename: Zhenbang
authors.initials: Z
authors.lastname: Lou
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*; D009861:Onium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D012492:Salts / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001713:Biphenyl Compounds; D009570:Nitriles; D009861:Onium Compounds; D011799:Quinazolines; D012492:Salts; C031291:diphenyliodonium