title: Prognostic value of baseline absolute lymphocyte concentration and neutrophil/lymphocyte ratio in dogs with newly diagnosed multi-centric lymphoma.
abstract: Canine multi-centric B-cell lymphoma shares similarities with diffuse large B-cell (Non-Hodgkin's) lymphoma (NHL) in people. In people with NHL, lymphopenia at diagnosis and first relapse and neutrophil/lymphocyte ratio (N:L) > 3.5 are negative prognostic factors for survival. The objective of this study was to determine if lymphocyte concentration at diagnosis and first relapse and N:L were prognostic for survival in dogs with newly diagnosed multi-centric lymphoma. Medical records of 77 dogs with multi-centric lymphoma treated with a CHOP-based chemotherapy protocol were retrospectively evaluated. Absolute lymphocyte concentration and N:L ratio at presentation of dogs pre-treated with steroids was not significantly different from dogs who had not received steroids. On multivariate analysis, only immunophenotype remained significant for progression-free survival (PFS), whereas no variables remained significant for ST. A prospective study of these haematologic variables is warranted to assess their true significance.
authors.affiliation: Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Mutz
authors.affiliation: Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
authors.forename: B
authors.initials: B
authors.lastname: Boudreaux
authors.affiliation: Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kearney
authors.affiliation: Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Stroda
authors.affiliation: Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Gaunt
authors.affiliation: Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Shiomitsu
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000401:mortality; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D018655:Lymphocyte Count / Q000662:veterinary*; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000401:mortality / Q000662:veterinary*; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use; D011379:Prognosis; D012189:Retrospective Studies; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: dogs; lymphoma; lymphopenia; prognosis