title: Highly efficient catalytic enantioselective Mannich reaction of malonates with N-tert-butoxycarbonyl imines by using Yb(OTf)3/pybox catalysts at room temperature.
abstract: Go Mannich! A highly efficient and enantioselective method for the direct asymmetric reaction of dibenzyl malonate with N-tert-butoxycarbonyl aldimines in the presence of Yb(OTf)3 and iPr-pybox complexes is described (see scheme; pybox = pyridine bisoxazoline).
authors.affiliation: Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-6731, Iran. karimi@iasbs.ac.ir
authors.forename: Babak
authors.initials: B
authors.lastname: Karimi
authors.forename: Ehsan
authors.initials: E
authors.lastname: Jafari
authors.forename: Dieter
authors.initials: D
authors.lastname: Enders
mesh_terms: D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D007097:Imines; D008314:Malonates; D008698:Mesylates; D009942:Organometallic Compounds; D011725:Pyridines; C518808:ytterbium(III) triflate
keywords: Mannich reactions; Yb(OTf)3; asymmetric catalysis; enantioselectivity; imines; pybox