title: Spatiotemporal expression of fibroblast growth factor 10 in human hindgut and anorectal development.
abstract: As fibroblast growth factor 10 (FGF-10) gene expression may have a role in anorectal duct formation, this study aimed to assess the spatiotemporal expression pattern of FGF-10 during development of the rectum and hindgut in human embryos. FGF-10 expression was evaluated in human embryos (n = 85) at 3-8 weeks of gestation after immunohistochemical evaluation using antibodies specific for FGF-10. From weeks 4 to 7 of gestation, FGF-10 expression was observed primarily in the apical epithelium of the dorsal urorectal septum, the cloacal membrane (CM) and the hindgut. Following CM rupture (week 7), the epithelium of the anal canal was negative for FGF-10; however, it was present within the urothelium through week 7. FGF-10 expression during the development of the human hindgut and anorectum suggests that it may play a role in hindgut and anorectal morphogenesis.
authors.affiliation: Department of Pediatric Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, PR China.
authors.forename: Shui Jing
authors.initials: SJ
authors.lastname: Yin
authors.forename: Xiao Bing
authors.initials: XB
authors.lastname: Tang
authors.forename: Fei Fei
authors.initials: FF
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Zheng Wei
authors.initials: ZW
authors.lastname: Yuan
authors.forename: Wei Lin
authors.initials: WL
authors.lastname: Wang
authors.forename: Yu Zuo
authors.initials: YZ
authors.lastname: Bai
mesh_terms: D001003:Anal Canal / Q000196:embryology* / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D051526:Fibroblast Growth Factor 10 / Q000032:analysis* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007150:Immunohistochemistry; D011247:Pregnancy; D012007:Rectum / Q000196:embryology* / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D051526:Fibroblast Growth Factor 10