title: Development of anti-influenza A compounds: a pilot study.
abstract: 1. There is no effective anti-H5N1 avian influenza agent. 2. A chemical compound— BFDBSC—can inhibit H5N1 virus infection in cell cultures, and such inhibition might be attributable to its halogenated benzoyl residues. 3. This pilot study assessed anti- H5N1 activity and toxicity of four chemical compounds with halogenated benzoyl residues in cell culture system. 4. Two compounds—FPBFDBSC and BFB-gallate— showed higher antiviral effectsthan BFDBSC, whearas the other two—BFB-borneol and BFB-menthol—showed lower antiviral effects. These compounds did not show toxicity. 5. The halogenated benzoyl residues may play a key role in anti-H5N1 effects. However, all these compounds showed poor solubility, which may limit their utility
authors.affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China. bzheng@hkucc.hku.hk
authors.forename: B J
authors.initials: BJ
authors.lastname: Zheng
authors.forename: C S
authors.initials: CS
authors.lastname: Chan
authors.forename: K M
authors.initials: KM
authors.lastname: Poon
authors.forename: F
authors.initials: F
authors.lastname: Ng
authors.forename: C M
authors.initials: CM
authors.lastname: Ho
authors.forename: C M
authors.initials: CM
authors.lastname: Che
authors.forename: K Y
authors.initials: KY
authors.lastname: Yuen
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D004285:Dogs; D015195:Drug Design; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D061985:Madin Darby Canine Kidney Cells; D010865:Pilot Projects; D012995:Solubility
chemical_list: D000998:Antiviral Agents