title: Microscopic features for initial diagnosis and disease activity evaluation in inflammatory bowel disease.
abstract: Inflammatory bowel disease is characterized by 2 major entities: Crohn's disease (CD) and ulcerative colitis (UC). In clinical practice, separation of UC and CD has been based on a variety of clinical features, symptoms, endoscopic and radiological, gross and microscopic characteristics. The microscopic diagnosis of inflammatory bowel disease is based on a combination of 2 types of lesions: architectural abnormalities and inflammatory features. However, microscopic distinction between these 2 entities can be difficult and often results in an interim diagnosis of "indeterminate colitis." Recommendations are made to encourage pathologists to give an indication of the activity of the disease: in UC, biopsies are used to discriminate between quiescent disease, inactive disease, and different grades of activity; in CD, evaluation of disease activity is limited and inactivity in the biopsy may not reflect inactivity in the patient. The aim of this review was to summarize microscopic features of inflammatory bowel disease for initial diagnosis and evaluation of disease activity in both CD and UC.
authors.affiliation: Inserm U954, Medical Faculty and CHU of Nancy, Nancy-Université, Nancy, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Bressenot
authors.forename: Karel
authors.initials: K
authors.lastname: Geboes
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Vignaud
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Guéant
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
mesh_terms: D018450:Disease Progression; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis*; D008853:Microscopy / Q000379:methods*; D011379:Prognosis; D012720:Severity of Illness Index