title: Multiplexed plasmon sensor for rapid label-free analyte detection.
abstract: Efficient and cost-effective multiplexed detection schemes for proteins in small liquid samples would bring drastic advances to fields like disease detection or water quality monitoring. We present a novel multiplexed sensor with randomly deposited aptamer functionalized gold nanorods. The spectral position of plasmon resonances of individual nanorods, monitored by dark-field spectroscopy, respond specifically to different proteins. We demonstrate nanomolar sensitivity, sensor recycling, and the potential to upscale to hundreds or thousands of targets.
authors.affiliation: Institute of Physical Chemistry, University of Mainz , Duesbergweg 10-14, D-55128 Mainz, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Rosman
authors.forename: Janak
authors.initials: J
authors.lastname: Prasad
authors.forename: Andreas
authors.initials: A
authors.lastname: Neiser
authors.forename: Andreas
authors.initials: A
authors.lastname: Henkel
authors.forename: Jonathan
authors.initials: J
authors.lastname: Edgar
authors.forename: Carsten
authors.initials: C
authors.lastname: Sönnichsen
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D036103:Nanotechnology / Q000295:instrumentation*; D040081:Protein Array Analysis / Q000295:instrumentation*; D011506:Proteins / Q000032:analysis* / Q000737:chemistry; D013194:Staining and Labeling; D020349:Surface Plasmon Resonance / Q000295:instrumentation*
chemical_list: D011506:Proteins