title: Generalized tonic-clonic seizures in adult patients following intravenous administration of desmopressin.
abstract: Desmopressin is a synthetic replacement for vasopressin, which is used to reduce perioperative blood loss. However, seizure attacks were observed in patients after administration of desmopressin. Here, we reported two cases of adult Chinese patients experienced generalized tonic-clonic seizures associated with severe hyponatremia caused by intravenously administered desmopressin after surgery. The patients' neurological conditions returned to baseline quickly and completely following discontinuation of desmopressin, control of the seizures, and fluid intake restriction. These cases illustrate the importance of periodic monitoring of electrolyte concentrations and fluid intake during use of desmopressin.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong County, Chongqing 400016, China.
authors.forename: Jiamei
authors.initials: J
authors.lastname: Guo
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Kebin
authors.initials: K
authors.lastname: Zeng
authors.forename: Guangyan
authors.initials: G
authors.lastname: Xu
authors.forename: Yungping
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects*; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D005260:Female; D006490:Hemostatics; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged
chemical_list: D006490:Hemostatics; D003894:Deamino Arginine Vasopressin