title: Sequential assessment of troponin in the diagnosis of myocardial infarction.
abstract: According to the American Heart Association, cardiovascular disease accounts for more than one third of all deaths in the United States. 1 The purpose of this retrospective case-control study was to determine which sample taken in a sequential draw was most important in diagnosing an acute myocardial infarction (AMI). One-hundred subjects were selected from a convenience sample. The "risk" of AMI diagnosis was modeled using binary multiple logistic regression. Overall, 78% (39 out of 50 cases) were diagnosed with an AMI at Tinitiai. Clearly, the initial cTnI assay is the most critical of the four sequential time points for the accurate assessment of the presence or absence of an AMI. Most importantly, sequential troponin testing increased the ability to diagnose AMI by 10-fold.
authors.affiliation: Department of Medical Laboratory, Imaging and Radiological Sciences, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Brandon
authors.initials: B
authors.lastname: Edwards
authors.forename: Irsha
authors.initials: I
authors.lastname: Washington
authors.forename: Lester
authors.initials: L
authors.lastname: Pretlow
authors.forename: Gregory
authors.initials: G
authors.lastname: Passmore
authors.forename: James
authors.initials: J
authors.lastname: Dias
authors.forename: Scott
authors.initials: S
authors.lastname: Wise
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004562:Electrocardiography; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I