title: Arabidopsis PPP family of serine/threonine protein phosphatases: many targets but few engines.
abstract: The major plant serine/threonine protein phosphatases belong to the phosphoprotein phosphatase (PPP) family. Over the past few years the complement of Arabidopsis thaliana PPP family of catalytic subunits has been cataloged and many regulatory subunits identified. Specific roles for PPPs have been characterized, including roles in auxin and brassinosteroid signaling, in phototropism, in regulating the target of rapamycin pathway, and in cell stress responses. In this review, we provide a framework for understanding the PPP family by exploring the fundamental role of the phosphatase regulatory subunits that drive catalytic engine specificity. Although there are fewer plant protein phosphatases compared with their protein kinase partners, their function is now recognized to be as dynamic and as regulated as that of protein kinases.
authors.affiliation: Department of Biological Sciences, University of Calgary, Canada.
authors.forename: R Glen
authors.initials: RG
authors.lastname: Uhrig
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Labandera
authors.forename: Greg B
authors.initials: GB
authors.lastname: Moorhead
mesh_terms: D017360:Arabidopsis / Q000201:enzymology*; D029681:Arabidopsis Proteins / Q000378:metabolism; D060406:Brassinosteroids / Q000378:metabolism; D020134:Catalytic Domain; D007210:Indoleacetic Acids / Q000378:metabolism; D013058:Mass Spectrometry; D005810:Multigene Family; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010802:Phylogeny; D010937:Plant Growth Regulators / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D060406:Brassinosteroids; D007210:Indoleacetic Acids; D010937:Plant Growth Regulators; D010749:Phosphoprotein Phosphatases
keywords: PP1; PP2A; PPP; acetylation; brassinosteroid; phototropism; protein phosphatase