title: Generating Better Medicines for Cancer.
abstract: The complexity of tumor biology warrants tailored drug delivery for overcoming the major challenges faced by cancer therapies. The versatility of the PRINT®(Particle Replication In Non-wetting Templates) process has enabled the preparation of shape- and size-specific particles with a wide range of chemical compositions and therapeutic cargos. Different particle matrices and drugs may be combined in a plug-and-play approach, such that physico-chemical characteristics of delivery vectors may be optimized for biocompatibility, cargo stability and release, circulation half-life, and efficacy. Thus, the engineering of particles for cancer therapy with specific biophysical behaviors and cellular responses has been demonstrated via the PRINT process.
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Stuart S
authors.initials: SS
authors.lastname: Dunn
authors.forename: James D
authors.initials: JD
authors.lastname: Byrne
authors.forename: Jillian L
authors.initials: JL
authors.lastname: Perry
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Desimone
keywords: PRINT; cancer; drug delivery; medicine; nanoparticle; soft lithography