title: Ocular surface complications after trabeculectomy: incidence, risk factors, time course and prognosis.
abstract: OBJECTIVE
  To investigate the incidence, risk factors, time course and prognosis of ocular surface complications after trabeculectomy.
  
  
  METHODS
  This is a retrospective, case-control study. Data on 399 consecutive patients who underwent trabeculectomy between 1999 and 2009 were evaluated. Cases of postoperative corneal epithelial defects, filamentary keratitis and dellen were evaluated. The risk factors for these ocular surface complications were analyzed with a logistic regression model.
  
  
  RESULTS
  Corneal epithelial defects were found in 44 of the 399 patients (11%), filamentary keratitis in 12 patients (3%) and dellen in 7 patients (2%). Dellen required surgical intervention at a statistically significantly higher rate than corneal epithelial defects or filamentary keratitis (p = 0.0001, Fisher's exact test). The significant risk factors for these ocular surface complications were found to be a history of preoperative superficial punctate keratopathy (odds ratio, OR: 2.10, 95% confidence interval, CI: 1.25-3.51, p = 0.005) and a history of diabetes mellitus (OR: 1.69, 95% CI: 1.02-2.81, p = 0.04).
  
  
  CONCLUSIONS
  Ocular surface complications following trabeculectomy are not rare. The biggest risk factors for these complications were found to be a history of preoperative superficial punctate keratopathy and a history of diabetes mellitus. Surgery is likely to be required for the treatment of dellen.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ono
authors.forename: Kenya
authors.initials: K
authors.lastname: Yuki
authors.forename: Naoki
authors.initials: N
authors.lastname: Ozeki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shiba
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000477:Alkylating Agents / Q000008:administration & dosage; D003316:Corneal Diseases / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014129:Trabecular Meshwork / Q000601:surgery*; D014130:Trabeculectomy
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin