title: [Innate immunity in neuroimmunological disorders].
abstract: Exogeneous pathogen-associated molecular patterns and endogenous danger signals bind to pattern recognition receptors and activate innate immunity cells, leading to proinflammatory cytokine production and activation of acquired immue cells. These are important factors in the pathogenesis of autoimmune-mediated neuroimmunological disorders such as multiple sclerosis. Furthermore, recent advances in the study of innate immunity revealed that innate immunity is a major players in the pathogenesis of some neuroimmunological diseases such as Behçet's disease and herpes simplex virus encephalitis.
authors.affiliation: Department of Immunology, National Institute of Neuroscience, National Center for Neurology and Psychiatry.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Miyake
mesh_terms: D000818:Animals; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007113:Immunity, Innate; D015213:Neuroimmunomodulation / Q000502:physiology; D051192:Receptors, Pattern Recognition / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology
chemical_list: D016207:Cytokines; D051192:Receptors, Pattern Recognition