title: Methotrexate-induced pulmonary toxicity.
abstract: Methotrexate is a widely used medication with an array of recognized side effects. The present report describes a case of methotrexate-induced pneumonitis in a patient with psoriasis, and demonstrates the hallmark clinical and investigational findings that support this infrequently encountered diagnosis. The ensuing discussion reviews the pathogenesis, management and prevention of this adverse drug reaction.
authors.affiliation: Faculty of Medicine, University of Toronto, Toronto, Ontario.
authors.forename: Baruch D
authors.initials: BD
authors.lastname: Jakubovic
authors.forename: Andrea
authors.initials: A
authors.lastname: Donovan
authors.forename: Peter M
authors.initials: PM
authors.lastname: Webster
authors.forename: Neil H
authors.initials: NH
authors.lastname: Shear
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D019468:Disease Management; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011565:Psoriasis / Q000188:drug therapy; D013902:Radiography, Thoracic
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate