title: Reduced palatability in pain-induced conditioned taste aversions.
abstract: The current study investigated whether internal pain-inducing agents can modulate palatability of a tastant in the same way as illness-inducing agents (e.g., lithium chloride). Similar to traditional conditioned taste aversion (CTA) experiments, during conditioning the rats were exposed to a saccharin solution followed by intraperitoneal injections of either gallamine (Experiment 1) or hypertonic sodium chloride (NaCl; Experiments 1 and 2). In addition to the total amount consumed, the time of each lick was recorded for lick pattern analysis. The results showed that both gallamine and hypertonic NaCl caused suppression in saccharin intake. Importantly, both lick cluster size and initial lick rate (the measures of taste palatability) were reduced as well. This pattern of results suggests that these pain-inducing agents reduce the hedonic value of the associated tastant and thus CTA is acquired. The current finding serves as evidence supporting the view that CTA is a broadly tuned mechanism that can be triggered by changes in internal body states following consummatory experience.
authors.affiliation: Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, United States. jlin2@uic.edu
authors.forename: Jian-You
authors.initials: JY
authors.lastname: Lin
authors.forename: Joe
authors.initials: J
authors.lastname: Arthurs
authors.forename: Steve
authors.initials: S
authors.lastname: Reilly
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical; D005247:Feeding Behavior / Q000187:drug effects*; D005703:Gallamine Triethiodide / Q000494:pharmacology; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000523:psychology*; D051381:Rats; D012439:Saccharin / Q000494:pharmacology; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D013649:Taste
chemical_list: D012462:Saline Solution, Hypertonic; D012439:Saccharin; D005703:Gallamine Triethiodide
keywords: Gallamine; Hypertonic sodium chloride; Lick cluster size; Lithium chloride; Rats