title: Implementation of a biocircuit implants for neurotransmitter release during neuro-stimulation.
abstract: Neurotransmitter assay of epinephrine (EP) was sought using a modified carbon nanotube paste electrode (PE). Using optimum conditions, cyclic voltammetry (CV) and the square wave (SW) stripping voltammetric working ranges were attained to 10-100 mgL(-1) (CV) and 20-140 ngL(-1) (SW). The relative standard deviation of 0.0549 (n=15) was obtained at 20.0 mgL(-1) EP constant. Here, the analytical detection limit (S/N) was reached with 4.60 ngL(-1) (2.5×10(-11) molL(-1)) EP. The hand-made electrode was implanted into the in-vivo brain core of the animals and was used in chronoamperometric neurodetection. The results obtained are applicable in neurosensing, physiological control, and other neuroscience fields.
authors.affiliation: Biosensor Research Institute, Seoul National University of Science & Technology, Seoul, Korea.
authors.forename: Suw Young
authors.initials: SY
authors.lastname: Ly
authors.forename: Dal woong
authors.initials: Dw
authors.lastname: Choi
mesh_terms: D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D004563:Electrochemistry / Q000379:methods*; D004567:Electrodes, Implanted; D037742:Nanotubes, Carbon; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats
chemical_list: D037742:Nanotubes, Carbon; D018377:Neurotransmitter Agents