title: [Perception of pain in rheumatoid arthritis: relation to inflammation, psychic disorders, functional status, and quality of life].
abstract: Pain perception was analyzed depending on the inflammatory activity of rheumatoid arthritis (RA), variants and manifestations of psychic disorders (including depressive, anxious and moderate cognitive ones), chronic fatigue, changes in the functional status and quality of life. The study included 125 patients (mean age 47.4 +/- 1.01 yr) with definitive diagnosis of RA 138.4 +/- 10.1 months in duration. RA activity was estimated from the DAS28 index, pain intensity and degree of fatigue by BPI and FSS scales respectively, the functional status and life quality by HAQ and EQ-5D. Psychic disorders were diagnosed by a psychiatrist in accordance with ICD-10 with the use of relevant psychiatric and psychological scales and methods. Pain perception was unrelated to the patients' age and RA duration. The multifactor analysis provided a basis for the prognostic model suggesting that the most severe pain in RA is related to the functional status and quality of life (VAS of general health status), hsCRP level, inflammatory activity index RA DAS28, peripheral platelet count, degree of fatigue (FSS) and depression (YADS), female sex. Depression and its severity is one more factor influencing pain perception in RA and accounting for functional insufficiency and low quality of life. Early diagnostics of psychic disorders (in the first place anxious and depressive ones) is mandatory to ensure effective combined therapy of pain in RA patients.
authors.forename: T A
authors.initials: TA
authors.lastname: Lisitsyna
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Vel'tishchev
authors.forename: A N
authors.initials: AN
authors.lastname: Gerasimov
authors.forename: O F
authors.initials: OF
authors.lastname: Seravina
authors.forename: O B
authors.initials: OB
authors.lastname: Kovalevskaia
authors.forename: A E
authors.initials: AE
authors.lastname: Zel'tyn'
authors.forename: A A
authors.initials: AA
authors.lastname: Novikov
authors.forename: E N
authors.initials: EN
authors.lastname: Aleksandrova
authors.forename: A V
authors.initials: AV
authors.lastname: Tallerova
authors.forename: L P
authors.initials: LP
authors.lastname: Kovalenko
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D003863:Depression / Q000503:physiopathology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006304:Health Status; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000503:physiopathology*; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology*; D058748:Pain Perception / Q000502:physiology*; D011239:Prednisolone / Q000008:administration & dosage; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone