title: Multimodal snapshot spectral imaging for oral cancer diagnostics: a pilot study.
abstract: Optical imaging and spectroscopy have emerged as effective tools for detecting malignant changes associated with oral cancer. While clinical studies have demonstrated high sensitivity and specificity for detection, current devices either interrogate a small region or can have reduced performance for some benign lesions. We describe a snapshot imaging spectrometer that combines the large field-of-view of widefield imaging with the diagnostic strength of spectroscopy. The portable device can stream RGB images at 7.2 frames per second and record both autofluorescence and reflectance spectral datacubes in < 1 second. We report initial data from normal volunteers and oral cancer patients.
authors.affiliation: Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.
authors.forename: Noah
authors.initials: N
authors.lastname: Bedard
authors.forename: Richard A
authors.initials: RA
authors.lastname: Schwarz
authors.forename: Aaron
authors.initials: A
authors.lastname: Hu
authors.forename: Vijayashree
authors.initials: V
authors.lastname: Bhattar
authors.forename: Jana
authors.initials: J
authors.lastname: Howe
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Williams
authors.forename: Ann M
authors.initials: AM
authors.lastname: Gillenwater
authors.forename: Rebecca
authors.initials: R
authors.lastname: Richards-Kortum
authors.forename: Tomasz S
authors.initials: TS
authors.lastname: Tkaczyk
keywords: (110.4234) Multispectral and hyperspectral imaging; (170.0170) Medical optics and biotechnology; (170.6510) Spectroscopy, tissue diagnostics