title: 18F-fluorodeoxyglucose positron emission tomography for the initial evaluation and monitoring of therapeutic response in bilateral adrenal histoplasmosis.
abstract: (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) of a 74-year-old man showed high FDG uptake in bilateral adrenal histoplasmosis. Four months after the administration of an appropriate antifungal treatment, we observed a significant decrease in FDG uptake into the lesions, with a 40% reduction in activity (maximal standardized uptake value). This imaging result indicated partial resolution of the disease and was consistent with clinical outcome. Our study results suggest that FDG-PET is a useful modality for initial whole-body evaluation, selection of an appropriate antifungal treatment regimen, and monitoring of therapeutic response in bilateral adrenal histoplasmosis.
authors.affiliation: Department of Nuclear Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Ya-Ju
authors.initials: YJ
authors.lastname: Tsai
authors.forename: Yi-Hsiang
authors.initials: YH
authors.lastname: Lin
authors.forename: Chung-Huei
authors.initials: CH
authors.lastname: Hsu
authors.forename: Shauh-Der
authors.initials: SD
authors.lastname: Yeh
mesh_terms: D000307:Adrenal Gland Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003366:Cosyntropin; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006660:Histoplasmosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D000935:Antifungal Agents; D019788:Fluorodeoxyglucose F18; D003366:Cosyntropin; D000666:Amphotericin B