title: KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603.
abstract: The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new Paenibacillus species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated as white powder by solvent extraction, HP-20 and ODS-B column chromatography, and lyophilization, and was determined to have the molecular formula C79H115N19O18. KB425796-A (1) showed antifungal activities against Aspergillus fumigatus and the micafungin-resistant infectious fungi Trichosporon asahii, Rhizopus oryzae, Pseudallescheria boydii and Cryptococcus neoformans.
authors.affiliation: Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan. hirohito.kai@astellas.com
authors.forename: Hirohito
authors.initials: H
authors.lastname: Kai
authors.forename: Midori
authors.initials: M
authors.lastname: Yamashita
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.forename: Michizane
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Muramatsu
authors.forename: Ikuko
authors.initials: I
authors.lastname: Nakamura
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Masami
authors.initials: M
authors.lastname: Ezaki
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nitta
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Noriaki
authors.initials: N
authors.lastname: Inamura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Fujie
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003455:Cryptococcus neoformans / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D025141:Drug Resistance, Fungal; D005285:Fermentation; D005612:Freeze Drying; D008826:Microbial Sensitivity Tests; D056507:Paenibacillus / Q000378:metabolism*; D011541:Pseudallescheria / Q000187:drug effects; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012233:Rhizopus / Q000187:drug effects; D017423:Sequence Analysis, RNA; D012997:Solvents / Q000737:chemistry; D014250:Trichosporon / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D047630:Depsipeptides; C584028:KB425796-A; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S; D012997:Solvents