title: The involvement of cholinergic neurons in the spreading of tau pathology.
abstract: Long time ago, it was described the selective loss of cholinergic neurons during the development of Alzheimer disease (AD). Recently, it has been suggested that tau protein may play a role in that loss of cholinergic neurons through a mechanism involving the interaction of extracellular tau with M1/M3 muscarinic receptors present in the cholinergic neurons. This interaction between tau and muscarinic receptors may be a way, although not the only one, to explain the spreading of tau pathology occurring in AD.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, CSIC-UAM Madrid, Spain ; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Madrid, Spain.
authors.forename: Diana
authors.initials: D
authors.lastname: Simón
authors.forename: Félix
authors.initials: F
authors.lastname: Hernández
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
keywords: cholinergic neurons; muscarinic receptors; tau