title: Uncontrollable haemorrhage following dabigatran prophylaxis.
abstract: An 88-year-old man, on dabigatran anticoagulation after a total hip replacement 1 week before admission, presented with acute abdominal pain associated with malaena and haematemesis. After examination and investigation, he was found to have a perforated viscus and underwent laparotomy. The perforation was surgically repaired, but the patient suffered from a massive haemorrhage during the operation, requiring intensive care admission postoperatively. The patient subsequently deteriorated despite aggressive treatment and died several days later.
authors.affiliation: Department of Anaesthetics, Stoke Mandeville Hospital, Bucks, UK. pavansingh@doctors.org.uk
authors.forename: Pavandeep Singh
authors.initials: PS
authors.lastname: Sandhu
authors.forename: Caroline
authors.initials: C
authors.lastname: Wilson
authors.forename: Emily
authors.initials: E
authors.lastname: Dalton
authors.forename: Alexey
authors.initials: A
authors.lastname: Bogdanov
mesh_terms: D000005:Abdomen; D000368:Aged; D000369:Aged, 80 and over; D000991:Antithrombins / Q000008:administration & dosage / Q000009:adverse effects*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D000069604:Dabigatran; D004632:Emergency Medical Services; D006470:Hemorrhage / Q000139:chemically induced / Q000601:surgery; D006801:Humans; D007813:Laparotomy; D008297:Male; D016896:Treatment Outcome; D015091:beta-Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000991:Antithrombins; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran