title: Practical selective hydrogenation of α-fluorinated esters with bifunctional pincer-type ruthenium(II) catalysts leading to fluorinated alcohols or fluoral hemiacetals.
abstract: Selective hydrogenation of fluorinated esters with pincer-type bifunctional catalysts RuHCl(CO)(dpa) 1a, trans-RuH2(CO)(dpa) 1b, and trans-RuCl2(CO)(dpa) 1c under mild conditions proceeds rapidly to give the corresponding fluorinated alcohols or hemiacetals in good to excellent yields. Under the optimized conditions, the hydrogenation of chiral (R)-2-fluoropropionate proceeds smoothly to give the corresponding chiral alcohol without any serious decrease of the ee value.
authors.affiliation: Chemical Research Center, Central Glass Co. Ltd., 2805 Imafuku-Nakadai Kawagoe, Saitama, 350-1151, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Otsuka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ishii
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Dub
authors.forename: Takao
authors.initials: T
authors.lastname: Ikariya
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011789:Quantum Theory; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000080:Acetals; D000438:Alcohols; D004952:Esters; D009942:Organometallic Compounds; D012428:Ruthenium