title: The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition.
abstract: Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.
authors.affiliation: Université Lille1, Unité de Catalyse et Chimie du Solide-UMR CNRS 8181, B.P. 90108, 59652 Villeneuve d'Ascq Cedex, France.
authors.forename: Faustine
authors.initials: F
authors.lastname: Dubar
authors.forename: Christian
authors.initials: C
authors.lastname: Slomianny
authors.forename: Jamal
authors.initials: J
authors.lastname: Khalife
authors.forename: Daniel
authors.initials: D
authors.lastname: Dive
authors.forename: Hadidjatou
authors.initials: H
authors.lastname: Kalamou
authors.forename: Yann
authors.initials: Y
authors.lastname: Guérardel
authors.forename: Philippe
authors.initials: P
authors.lastname: Grellier
authors.forename: Christophe
authors.initials: C
authors.lastname: Biot
mesh_terms: D000634:Aminoquinolines / Q000627:therapeutic use*; D000962:Antimalarials / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects* / Q000469:parasitology; D005296:Ferrous Compounds / Q000627:therapeutic use*; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry*; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D000075163:Metallocenes; D010084:Oxidation-Reduction; D010963:Plasmodium falciparum / Q000472:pathogenicity*
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; D005296:Ferrous Compounds; D000075163:Metallocenes; D017665:Hydroxyl Radical; C479230:ferroquine
keywords: bioorganometallic chemistry; ferroquine; malaria; reactive species; subcellular imaging