title: Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI.
abstract: CONCLUSIONS
  Endolymphatic hydrops could be a reversible inner ear pathological condition. After sac surgery, hydrops was reduced and symptoms went into remission in some cases, although vertigo suppression was not always a result of the reduced hydrops.
  
  
  OBJECTIVE
  To examine the changes in endolymphatic hydrops detected by gadolinium (Gd) contrast-enhanced magnetic resonance imaging (MRI) before and 6 months after endolymphatic sac surgery in patients with unilateral Ménière's disease.
  
  
  METHODS
  Fluid-attenuated inversion recovery MRI was obtained 4 h after intravenous administration or 24 h after intratympanic administration of Gd contrast medium. An enlarged negative stain corresponding to the cochlear duct and endolymphatic space of the vestibule was assessed as hydrops.
  
  
  RESULTS
  Of seven patients with hydrops confirmed by MRI before surgery, both cochlear and vestibular hydrops became negative in two, cochlear hydrops became negative in one, both hydrops were present, but reduced, in one, and there was no change in three patients. The number of vertigo spells was reduced in all cases at 6-12 months after surgery. As for the three cases of negative hydrops, vertigo was completely suppressed. In two cases in which hearing level improved, hydrops became negative after surgery.
authors.affiliation: Department of Otolaryngology Head & Neck Surgery, Japan. auno@ent.med.osaka-u.ac.jp
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Uno
authors.forename: Takao
authors.initials: T
authors.lastname: Imai
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kitahara
authors.forename: Arata
authors.initials: A
authors.lastname: Horii
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kamakura
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Takimoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Osaki
authors.forename: Suetaka
authors.initials: S
authors.lastname: Nishiike
authors.forename: Hidenori
authors.initials: H
authors.lastname: Inohara
mesh_terms: D000328:Adult; D003287:Contrast Media; D018159:Endolymphatic Hydrops / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D004712:Endolymphatic Sac / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA