title: Reconstructed stem cell nanoghosts: a natural tumor targeting platform.
abstract: The ultimate goal in cancer therapy is achieving selective targeting of cancer cells. We report a novel delivery platform, based on nanoghosts (NGs) produced from the membranes of mesenchymal stem cells (MSCs). Encompassing MSC surface molecules, the MSC-NGs retained MSC-specific in vitro and in vivo tumor targeting capabilities and were cleared from blood-filtering organs. MSC-NGs were found to be biocompatible. Systemic administration of drug loaded MSC-NGs demonstrated 80% inhibition of human prostate cancer.
authors.affiliation: Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology , Haifa 32000, Israel.
authors.forename: Naama E
authors.initials: NE
authors.lastname: Toledano Furman
authors.forename: Yael
authors.initials: Y
authors.lastname: Lupu-Haber
authors.forename: Tomer
authors.initials: T
authors.lastname: Bronshtein
authors.forename: Limor
authors.initials: L
authors.lastname: Kaneti
authors.forename: Nitzan
authors.initials: N
authors.lastname: Letko
authors.forename: Eyal
authors.initials: E
authors.lastname: Weinstein
authors.forename: Limor
authors.initials: L
authors.lastname: Baruch
authors.forename: Marcelle
authors.initials: M
authors.lastname: Machluf
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000737:chemistry*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D009928:Organ Specificity; D010316:Particle Size; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D053769:Nanocapsules; D010446:Peptide Fragments; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; C547552:soluble tumor necrosis factor-related apoptosis-inducing ligand (114-281), rat