title: Analysis of cancer tissues by means of spectroscopic methods.
abstract: The personalized approach in cancer treatment stimulates the search for new analytical techniques, including spectroscopic methods such as Raman spectroscopy, mass spectrometry MALDI (matrix-assisted laser desorption/ionization) imaging and high-resolution magic angle spinning nuclear magnetic resonance (HR MAS NMR). The purpose of these studies is determination of metabolic profiles of cancer tissues, and their application in diagnostics and therapy of cancers. The review is mainly focused on application of HR MAS NMR technique. Qualitative and quantitative analysis of metabolites by means of this method is described for breast cancer tissues. In the near future HR MAS NMR in vitro studies of metabolic profiles combined with in vivo studies using MRI scanners may be applied as a new diagnostic tool.
authors.affiliation: Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Pacholczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Fabiańska
authors.forename: Renata
authors.initials: R
authors.lastname: Kusińska
authors.forename: Piotr
authors.initials: P
authors.lastname: Potemski
authors.forename: Radzisław
authors.initials: R
authors.lastname: Kordek
authors.forename: Stefan
authors.initials: S
authors.lastname: Jankowski
keywords: MALDI MS imaging; Raman spectroscopy; metabolic profile; nuclear magnetic resonance; tumor