title: Dual-imaging system for burn depth diagnosis.
abstract: Currently, determination of burn depth and healing outcomes has been limited to subjective assessment or a single modality, e.g., laser Doppler imaging. Such measures have proven less than ideal. Recent developments in other non-contact technologies such as optical coherence tomography (OCT) and pulse speckle imaging (PSI) offer the promise that an intelligent fusion of information across these modalities can improve visualization of burn regions thereby increasing the sensitivity of the diagnosis. In this work, we combined OCT and PSI images to classify the degree of burn (superficial, partial-thickness and full-thickness burns). Algorithms were developed to integrate and visualize skin structure (with and without burns) from the two modalities. We have completed the proposed initiatives by employing a porcine burn model and compiled results that attest to the utility of our proposed dual-modal fusion approach. Computer-derived data indicating the varying burn depths were validated through immunohistochemical analysis performed on burned skin tissue. The combined performance of OCT and PSI modalities provided an overall ROC-AUC=0.87 (significant at p<0.001) in classifying different burn types measured after 1-h of creating the burn wounds. Porcine model studies to assess feasibility of this dual-imaging system for wound tracking are underway.
authors.affiliation: UtopiaCompression Corporation, 11150W Olympic Blvd., Suite # 320, Los Angeles, CA 90064, USA. Electronic address: priya@utopiacompression.com.
authors.forename: Priya
authors.initials: P
authors.lastname: Ganapathy
authors.affiliation: UtopiaCompression Corporation, 11150W Olympic Blvd., Suite # 320, Los Angeles, CA 90064, USA.
authors.forename: Tejaswi
authors.initials: T
authors.lastname: Tamminedi
authors.affiliation: Department of Biomedical Engineering, 1042 Downey Way, Denney Research Center (DRB) 140, Viterbi School of Engineering, USC., Los Angeles, CA 90089-1111, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Plastic Surgery Research Laboratory, S-2221 MCN Vanderbilt School of Medicine, Nashville, TN 37232, USA.
authors.forename: Lillian
authors.initials: L
authors.lastname: Nanney
authors.affiliation: Plastic Surgery Research Laboratory, S-2221 MCN Vanderbilt School of Medicine, Nashville, TN 37232, USA.
authors.forename: Nancy
authors.initials: N
authors.lastname: Cardwell
authors.affiliation: Plastic Surgery Research Laboratory, S-2221 MCN Vanderbilt School of Medicine, Nashville, TN 37232, USA.
authors.forename: Alonda
authors.initials: A
authors.lastname: Pollins
authors.affiliation: Plastic Surgery Research Laboratory, S-2221 MCN Vanderbilt School of Medicine, Nashville, TN 37232, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Sexton
authors.affiliation: UtopiaCompression Corporation, 11150W Olympic Blvd., Suite # 320, Los Angeles, CA 90064, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Yadegar
mesh_terms: D000818:Animals; D002056:Burns / Q000175:diagnosis*; D004195:Disease Models, Animal; D008833:Microcirculation; D064847:Multimodal Imaging; D012867:Skin / Q000098:blood supply* / Q000473:pathology; D013552:Swine; D041623:Tomography, Optical Coherence
keywords: Burn diagnosis; Dual-modality for burn diagnosis; Full-thickness burns; Immunohistochemical staining; Optical coherence tomography; Partial-thickness burns; Porcine model; Pulse speckle imaging