title: Clustering Based on Periodicity in High-Throughput Time Course Data.
abstract: Nuclear magnetic resonance (NMR) spectroscopy, traditionally used in analytical chemistry, has recently been introduced to studies of metabolite composition of biological fluids and tissues. Metabolite levels change over time, and providing a tool for better extraction of NMR peaks exhibiting periodic behavior is of interest. We propose a method in which NMR peaks are clustered based on periodic behavior. Periodic regression is used to obtain estimates of the parameter corresponding to period for individual NMR peaks. A mixture model is then used to develop clusters of peaks, taking into account the variability of the regression parameter estimates. Methods are applied to NMR data collected from human blood plasma over a 24-hour period. Simulation studies show that the extra variance component due to the estimation of the parameter estimate should be accounted for in the clustering procedure.
authors.affiliation: Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Blackstock
authors.forename: Amita K
authors.initials: AK
authors.lastname: Manatunga
authors.forename: Youngja
authors.initials: Y
authors.lastname: Park
authors.forename: Dean P
authors.initials: DP
authors.lastname: Jones
authors.forename: Tianwei
authors.initials: T
authors.lastname: Yu