title: Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives.
abstract: 3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an interesting activity against the tested strain of Mycobacterium tuberculosis H37Rv. The results suggest that 1,3,4-oxadiazoles and 5-pyrazolinones bearing a core pyrazole scaffold may be promising antifungal and antitubercular agents.
authors.affiliation: Institute for Sciences and Technology in Medicine, Keele University, Keele, Staffordshire, ST5 5BG, UK.
authors.forename: P
authors.initials: P
authors.lastname: Horrocks
authors.forename: M R
authors.initials: MR
authors.lastname: Pickard
authors.forename: H H
authors.initials: HH
authors.lastname: Parekh
authors.forename: S P
authors.initials: SP
authors.lastname: Patel
authors.forename: Ravindra B
authors.initials: RB
authors.lastname: Pathak
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D011720:Pyrazoles; C031280:pyrazole