title: Light-induced catalytic and cytotoxic properties of phosphorescent transition metal compounds with a d8 electronic configuration.
abstract: Transition metal compounds are well documented to have diverse applications such as in catalysis, light-emitting materials and therapeutics. In the areas of photocatalysis and photodynamic therapy, metal compounds of heavy transition metals are highly sought after because they can give rise to triplet excited states upon photoexcitation. The long lifetimes (more than 1 μs) of the triplet states of transition metal compounds allow for bimolecular reactions/processes such as energy transfer and/or electron transfer to occur. Reactions of triplet excited states of luminescent metal compounds with oxygen in cells may generate reactive oxygen species and/or induce damage to DNA, leading to cell death. This article recaps the recent findings on photochemical and phototoxic properties of luminescent platinum(II) and gold(III) compounds both from the literature and experimental results from our group.
authors.affiliation: State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, Republic of China.
authors.forename: Wai-Pong
authors.initials: WP
authors.lastname: To
authors.forename: Taotao
authors.initials: T
authors.lastname: Zou
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D002384:Catalysis / Q000528:radiation effects; D004249:DNA Damage; D006046:Gold / Q000737:chemistry / Q000528:radiation effects / Q000627:therapeutic use*; D008027:Light; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology*; D010778:Photochemotherapy / Q000639:trends*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D010984:Platinum / Q000737:chemistry / Q000528:radiation effects / Q000627:therapeutic use*; D028561:Transition Elements / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D017319:Photosensitizing Agents; D028561:Transition Elements; D010984:Platinum; D006046:Gold
keywords: cancer; gold; photocatalysis; phototoxicity; platinum