title: The regulation network and network motif analysis in ovarian cancer.
abstract: OBJECTIVE
  Several gene alterations have been identified associated with ovarian cancer (OC) development. However, how these genetic elements are coordinated in transcription network during OC initiation and progression is poorly understood. Thus, the objective of this study was to interpret the transcription regulation network of OC.
  
  
  METHODS
  The GSE14407 microarray data was used for analysis of the transcription regulation network of OC.
  
  
  RESULTS
  The results showed that the TP53 (tumor protein p53) was the most crucial transcription factor in the transcriptome network. P53 could down-regulate CDC14A (CDC14 cell division cycle 14 homolog A [S. cerevisiae]) and FAS (TNF receptor superfamily, member 6) expression, but up-regulate SFN (stratifin) and THBS1 (thrombospondin 1) expression to involve in pathways in cancer, cell cycle, p53 signaling pathway, and apoptosis pathway.
  
  
  CONCLUSIONS
  This transcriptional regulation may provide a better understanding of molecular mechanism and some potential therapeutic targets in the treatment of OC.
authors.affiliation: Department of Reproductive Medicine, Renji Hospital, Shanghai Jliaotong University, School of Medicine, Shanghai, China.
authors.forename: A-juan
authors.initials: AJ
authors.lastname: Liang
authors.forename: Yan
authors.initials: Y
authors.lastname: Hong
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.forename: Min-zhi
authors.initials: MZ
authors.lastname: Gao
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Zhao
mesh_terms: D048948:14-3-3 Proteins / Q000235:genetics / Q000502:physiology; D014408:Biomarkers, Tumor / Q000235:genetics / Q000502:physiology; D005092:Exonucleases / Q000235:genetics / Q000502:physiology; D005095:Exoribonucleases; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010051:Ovarian Neoplasms / Q000235:genetics*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics / Q000502:physiology; D017027:Protein Tyrosine Phosphatases; D019700:Thrombospondin 1 / Q000235:genetics / Q000502:physiology
chemical_list: D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; D019700:Thrombospondin 1; D005092:Exonucleases; D005095:Exoribonucleases; C413442:SFN protein, human; D010744:Phosphoric Monoester Hydrolases; C120902:CDC14A protein, human; D017027:Protein Tyrosine Phosphatases