title: A study of ERα PvuII polymorphism in female patients with acute stroke: no associations with disease severity and early outcome.
abstract: Several studies have examined the association of the PvuII polymorphism of the estrogen receptor alpha gene with the risk of stroke. Data linking the polymorphism with the severity and outcome of cerebrovascular disease are lacking. In this study, we evaluated 285 postmenopausal Caucasian patients suffering an acute stroke, hospitalized in two tertiary hospitals over a period of 2 years, and searched for associations between the PvuII polymorphism and the one-month outcome and the neurological severity on admission. The prevalence of CC genotype was 21%, CT 50% and TT 29%. Estradiol levels were higher with increasing frequencies of the C allele (p = 0.04). There was no difference in the short-term functional outcome and mortality and the neurological severity on admission among the three genotypes. We did not find a significant association of the PvuII polymorphism with intracerebral hemorrhage and classical stroke risk factors. An association of the CC genotype with venous thromboembolism history was recorded (p 0.05). There was no association between the PvuII polymorphism and stroke severity and short-term outcome in the studied female stroke population. It is possible that the long-term estrogenic action, reflected by the genetic polymorphism, is not a major determinant of disease severity and prognosis in older age.
authors.affiliation: Endocrine Unit, Department of Clinical Therapeutics, Athens University School of Medicine, Alexandra Hospital, 80 Vassilissis Sofias Avenue, 11528 Athens, Greece. dorispappas@hotmail.com
authors.forename: Theodora
authors.initials: T
authors.lastname: Pappa
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vemmos
authors.forename: Kimon
authors.initials: K
authors.lastname: Stamatelopoulos
authors.forename: Emily
authors.initials: E
authors.lastname: Mantzou
authors.forename: George
authors.initials: G
authors.lastname: Georgiopoulos
authors.forename: Sofia
authors.initials: S
authors.lastname: Markoula
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zakopoulos
authors.forename: Maria
authors.initials: M
authors.lastname: Alevizaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015257:DNA-Cytosine Methylases / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D012720:Severity of Illness Index; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; C047084:DNA modification methylase PvuII; D015257:DNA-Cytosine Methylases