title: Use of hypophysin in hypotensive patients with low systemic vascular resistance following cardiopulmonary bypass.
abstract: OBJECTIVE
  This study aimed to test the effects of hypophysin on hemodynamics and coronary artery caliber of patients with hypotension and decreased systemic vascular resistance (SVR) following cardiopulmonary bypass (CPB).
  
  
  METHODS
  Twenty-four patients with mean arterial pressure (MAP) < 60 mmHg, mean aorta pressure < 70 mmHg, SVR < 800 dynes.sec.cm-5, cardiac index (CI) > 2.5 l.min-1.m-2, central venous pressure > 8 mmHg and refractory to dopamine, norepinephrine, and fluid resuscitation were treated with hypophysin at an initial dose of 0.6 IU and a continuous infusion rate of 1 - 4 IU/h till the end of operation. The hemodynamics and the diameter of proximal left main coronary artery were evaluated before incision, before hypophysin administration, 5 min after hypophysin administration, and at the end of operation.
  
  
  RESULTS
  MAP, SVR, and the diameter of proximal left main coronary artery increased whereas heart rate, CI, stroke volume index, and mean pulmonary artery pressure had no significant changes after hypophysin administration compared with before hypophysin administration. All hypophysin-treated patients successfully recovered.
  
  
  CONCLUSIONS
  Hypophysin may improve the hemodynamics and dilate the proximal left main coronary artery in hypotensive patients with low SVR following CPB.
authors.affiliation: Department of Anesthesiology, Yangzhou NO.1 People's Hospital, Yangzhou, China.
authors.forename: Zhuan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Shi
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Sun
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Ge
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wei
authors.forename: Mu-Huo
authors.initials: MH
authors.lastname: Ji
authors.forename: Man-lin
authors.initials: ML
authors.lastname: Duan
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D062186:Arterial Pressure / Q000187:drug effects; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010909:Pituitary Hormones, Posterior / Q000627:therapeutic use*; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D010909:Pituitary Hormones, Posterior; C010591:hypophysin