title: [MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas].
abstract: BACKGROUND
  Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis.
  
  
  OBJECTIVE
  The aim of the authors was to compare the miRNA-expression profile of breast- and salivary gland-derived cases.
  
  
  METHODS
  The miRNA-profiles of two salivary gland derived and two breast-derived adenoid cystic carcinoma tissues as well as one normal breast and one salivary gland tissues were analysed using the Affymetrix® Gene Chip.
  
  
  RESULTS
  The expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma. In addition, the miR-24 was decreased in salivary gland-derived but overexpressed in breast-derived adenoid cystic carcinomas. The miR-181a-2* was only detected in salivary gland-derived adenoid cystic carcinomas.
  
  
  CONCLUSIONS
  Through post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar, II. Patológiai Intézet, Budapest. kj@korb2.sote.hu
authors.forename: Orsolya
authors.initials: O
authors.lastname: Kiss
authors.forename: Anna-Mária
authors.initials: AM
authors.lastname: Tőkés
authors.forename: Sándor
authors.initials: S
authors.lastname: Spisák
authors.forename: Anna
authors.initials: A
authors.lastname: Szilágyi
authors.forename: Norbert
authors.initials: N
authors.lastname: Lippai
authors.forename: A Marcell
authors.initials: AM
authors.lastname: Szász
authors.forename: Janina
authors.initials: J
authors.lastname: Kulka
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000235:genetics*; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics*; D015536:Down-Regulation; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000032:analysis*; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000235:genetics*; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C543845:MIRN24 microRNA, human; C540193:MIrn181 microRNA, human; D035683:MicroRNAs; C487931:mirnlet7 microRNA, human