title: Total synthesis of spirobacillene A.
abstract: The first total synthesis of spirobacillene A, an indole alkaloid isolated from Lysinibacillus fusiformis, is reported. A Lewis acid mediated spirocyclization of an anisole derivative onto a tethered ynone was used as a key step, drawing inspiration from a potential biosynthesis of the natural product.
authors.affiliation: Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. william.unsworth@york.ac.uk
authors.forename: William P
authors.initials: WP
authors.lastname: Unsworth
authors.forename: James D
authors.initials: JD
authors.lastname: Cuthbertson
authors.forename: Richard J K
authors.initials: RJ
authors.lastname: Taylor
mesh_terms: D000840:Anisoles / Q000737:chemistry*; D003500:Cyclization; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D000840:Anisoles; D003517:Cyclopentanes; D026121:Indole Alkaloids; D058116:Lewis Acids; D013141:Spiro Compounds; C579583:spirobacillene A