title: Peripheral blood cell variations in cirrhotic portal hypertension patients with hypersplenism.
abstract: OBJECTIVE
  To explore peripheral blood cell variations in hepatic cirrhosis portal hypertension patients with hypersplenism.
  
  
  METHODS
  Clinical data of 322 hypersplenism patients with decreased peripheral blood cells, admitted with cirrhotic portal hypertension, was retrospectively studied over the last 17 years.
  
  
  RESULTS
  In 64% (206/322) of patients, more than 2 kinds of blood cell were decreased, including 89 cases of pancytopenia (43.2%), 52 cases of WBC + PLT decrease (25.2%), 29 cases of RBC + PLT decrease (14.1%), and 36 cases of WBC + RBC decrease (17.5%); in 36% (116/322) of patients, single type blood cell decrease occurred, including 31 cases of PLT decrease (26.7%), 29 cases of WBC decrease (25%) and 56 cases of RBC decrease (48.3%). Of 227 routine bone marrow examinations, bone marrow hyperplasia was observed in 118 cases (52.0%), the remainder showed no hyperplasia. For the distinct scope and extent of peripheralblood cell decreases, preoperative blood component transfusions were carried out, then treated by surgery, after whole group splenectomy, the peripheral blood cell count was significantly higher (P<0.05).
  
  
  CONCLUSIONS
  Of portal hypertensive patients with splenomegaly and hypersplenism, 64% have simultaneous decrease in various blood cells, 36% have decrease in single type blood cells, 52% of patients have bone marrow hyperplasia. A splenectomy can significantly increase the reduction of peripheral blood cells.
authors.affiliation: Department of Surgery, People's Hospital of Hainan Province, Haikou, China.
authors.forename: Yun-Fu
authors.initials: YF
authors.lastname: Lu
authors.forename: Xin-Qiu
authors.initials: XQ
authors.lastname: Li
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Han
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Gong
authors.forename: Shun-Wu
authors.initials: SW
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006971:Hypersplenism / Q000473:pathology* / Q000601:surgery; D006975:Hypertension, Portal / Q000150:complications* / Q000473:pathology*; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013156:Splenectomy; D055815:Young Adult