title: [Antiganglioside complex antibody].
abstract: Antiganglioside antibodies are known to play a pathogenic role in development of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS). Recently, antibodies to ganglioside complexes (GSCs) consisting of two different gangliosides were found in some patients with GBS and FS. Some anti-GSC antibodies such as anti-GD1a/GD1b, anti-GM1/GQ1b or anti-GM1/GalNAc-GD1a antibodies correlate with specific clinical features. Anti-GSCs antibodies can be found also in chronic inflammatory demyelinating polyneuropathy and neuropathy associated with IgM monoclonal gammopathy. Latest studies have revealed molecular basis of anti-GSCs antibody-mediated nerve injury. The concept of GSCs will provide new vistas on understanding of pathogenesis of GBS and related autoimmune diseases.
authors.affiliation: Division of Neurology, Department of Internal Medicine 3, National Defense Medical College.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hongo
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kaida
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D019846:Miller Fisher Syndrome / Q000175:diagnosis / Q000276:immunology*
chemical_list: D000906:Antibodies; D015415:Biomarkers; D005732:Gangliosides