title: Development of nephrolithiasis in a renal transplant patient during treatment with Cinacalcet.
abstract: BACKGROUND
  Secondary hyperparathyroidism often accompanies chronic kidney disease, which can result in severe bone abnormalities and nephrolithiasis. Renal transplantation can correct the mineral abnormalities associated with chronic kidney disease, but one year after transplantation many recipients continue to exhibit persistent hyperparathyroidism.
  
  
  METHODS
  Cinacalcet, a second-generation calcimimetic, has been shown to be effective in decreasing serum calcium levels in post kidney transplant patients with hyperparathyroidism. However a question remains whether patients with hyperparathyroidism who take Cinacalcet may be at increased risk of renal calcium deposits due to hypercalciuria and subsequent renal transplant dysfunction. We report the first well-documented case in which Cinacalcet contributed to the development of new renal calculi in a post-transplant patient with hyperparathyroidism (PTH 346 pg/mL), hypercalcemia (11.3 mg/dL), and good renal function (1.45 mg/dL). Interval imaging tracks the new onset of renal allograft stone formation after initiating Cinacalcet up to 60mg daily, which was accompanied by persistent hypercalciuria (478.2 mg/24 hours). The nephrolithiases resolved after discontinuing Cinacalcet and a subtotal parathyroidectomy.
  
  
  CONCLUSIONS
  This case supports the interval monitoring of urinary calcium excretion and imaging of the transplanted kidney for those recipients treated with Cinacalcet for hyperparathyroidism after renal transplantation.
authors.affiliation: Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Seager
authors.forename: Titte R
authors.initials: TR
authors.lastname: Srinivas
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Flechner
mesh_terms: D000328:Adult; D057966:Calcimimetic Agents / Q000009:adverse effects*; D002118:Calcium / Q000378:metabolism; D000069449:Cinacalcet; D006801:Humans; D053565:Hypercalciuria / Q000209:etiology; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009281:Naphthalenes / Q000009:adverse effects*; D053040:Nephrolithiasis / Q000000981:diagnostic imaging / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D057966:Calcimimetic Agents; D009281:Naphthalenes; D002118:Calcium; D000069449:Cinacalcet