title: Succinate: a new epigenetic hacker.
abstract: Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.
authors.affiliation: Cancer Biology and Metabolism Group, Nuffield Department of Medicine, Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, UK.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Pollard
mesh_terms: D000818:Animals; D019175:DNA Methylation; D005260:Female; D006801:Humans; D008297:Male; D010235:Paraganglioma / Q000473:pathology*; D013385:Succinate Dehydrogenase / Q000235:genetics*
chemical_list: D013385:Succinate Dehydrogenase