title: Deep sequencing of the transcriptome reveals inflammatory features of porcine visceral adipose tissue.
abstract: Functional differences in the different types of adipose tissue and the impact of their dysfunction on metabolism are associated with the regional distribution of adipose depots. Here we show a genome-wide comparison between the transcriptomes of one source of subcutaneous and two sources of visceral adipose tissue in the pig using an RNA-seq approach. We obtained ~32.3 million unique mapped reads which covered ~80.2% of the current annotated transcripts across these three sources of adipose tissue. We identified various genes differentially expressed between subcutaneous and visceral adipose tissue, which are potentially associated with the inflammatory features of visceral adipose tissue. These results are of benefit for understanding the phenotypic, metabolic and functional differences between different types of adipose tissue that are deposited in different body sites.
authors.affiliation: Institute of Animal Genetics & Breeding, College of Animal Science & Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Anan
authors.initials: A
authors.lastname: Jiang
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Guo
authors.forename: Ya
authors.initials: Y
authors.lastname: Tan
authors.forename: Guoqing
authors.initials: G
authors.lastname: Tang
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Mai
authors.forename: Haifeng
authors.initials: H
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.forename: Mingzhou
authors.initials: M
authors.lastname: Li
authors.forename: Xuewei
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D007249:Inflammation / Q000235:genetics / Q000473:pathology*; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology*; D017423:Sequence Analysis, RNA; D013552:Swine; D059467:Transcriptome
chemical_list: D005227:Fatty Acids
keywords: RNA-seq; fatty acid metabolism; inflammatory; pig.; subcutaneous adipose tissue; visceral adipose tissue