title: Design and development of nanocomposite scaffolds for auricular reconstruction.
abstract: Auricular reconstruction using sculpted autologous costal cartilage is effective, but complex and time consuming and may incur donor site sequelae and morbidity. Conventional synthetic alternatives are associated with infection and extrusion in up to about 15% of cases. We present a novel POSS-PCU nanocomposite auricular scaffold, which aims to reduce extrusion rates by mimicking the elastic modulus of human ears and by encouraging desirable cellular interactions. The fabrication, physicochemical properties (including nanoscale topography) and cellular interactions of these scaffolds were compared to Medpor®, the current synthetic standard. Our scaffold had a more similar elastic modulus (5.73 ± 0.17MPa) to ear cartilage (5.02 ± 0.17MPa) compared with Medpor®, which was much stiffer (140.9 ± 0.04MPa). POSS-PCU supported fibroblast ingrowth and proliferation; significantly higher collagen production was also produced by cells on the POSS-PCU than those on Medpor®. This porous POSS-PCU nanocomposite scaffold is therefore a promising alternative biomaterial for auricular surgical reconstruction.
  
  
  BACKGROUND
  In this paper, a novel POSS-PCU nanocomposite auricular scaffold is described to reduce extrusion rates by having a much closer elastic modulus of human ears than the currently available synthetic standard. Enabling desirable cellular interactions may lead to the successful clinical application of these novel scaffolds.
authors.affiliation: Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London, London, UK.
authors.forename: Leila
authors.initials: L
authors.lastname: Nayyer
authors.affiliation: UCL Ear Institute, University College London, London, UK; Royal National Throat Nose and Ear Hospital, University College London, London, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Birchall
authors.affiliation: Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London, London, UK; Department of Plastic and Reconstructive Surgery, Royal Free London NHS Foundation Trust Hospital, London, UK. Electronic address: a.seifalian@ucl.ac.uk.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Seifalian
authors.affiliation: Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London, London, UK.
authors.forename: Gavin
authors.initials: G
authors.lastname: Jell
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D004423:Ear / Q000601:surgery; D004425:Ear Cartilage / Q000737:chemistry* / Q000637:transplantation; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use*; D017646:Organosilicon Compounds / Q000737:chemistry / Q000627:therapeutic use; D011095:Polyethylenes / Q000737:chemistry / Q000627:therapeutic use; D019736:Prostheses and Implants; D019651:Plastic Surgery Procedures; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; C084562:Medpor; D017646:Organosilicon Compounds; D011095:Polyethylenes
keywords: Auricle; Medpor®; Nanocomposite; POSS-PCU