title: [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice].
abstract: The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice. It has been found that DCS administered intraperitoneally for 7 days in a dose of 10 mg/kg produces a significant anticonvulsant effect on the model of corazole-induced seizures. The drug increases the latency of corazole-induced seizures, changes the character of seizures, and increases lifespan of animals, while not protecting against loss. At the same time, DCS does not exhibit any effect on ME-induced seizures.
authors.forename: V M
authors.initials: VM
authors.lastname: Rychikhin
authors.forename: A K
authors.initials: AK
authors.lastname: Sariev
authors.forename: I A
authors.initials: IA
authors.lastname: Pomytkin
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D003292:Convulsants / Q000009:adverse effects / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D010433:Pentylenetetrazole / Q000009:adverse effects / Q000494:pharmacology; D010875:Pipecolic Acids / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D010875:Pipecolic Acids; D013386:Succinates; C016374:dicolin; D002794:Choline; D010433:Pentylenetetrazole