title: New spectrophotometric estimation of indomethacin capsules with niacinamide as hydrotropic solubilizing agent.
abstract: BACKGROUND
  Hydrotropic solubilization process involves cooperative intermolecular interaction with several balancing molecular forces, rather than either a specific complexation event or a process dominated by a medium effect, such as co-solvency or salting-in.
  
  
  METHODS
  In the present investigation, hydrotropic solution of 2 M niacinamide was employed as the solubilizing agent to solubilize the poorly water-soluble drug, indomethacin, from the capsule dosage form for spectrophotometric determination in ultraviolet region.
  
  
  RESULTS
  Hydrotropic agent used did not interfere in the spectrophotometric analysis. In preliminary solubility studies, it was found that there was more than fivefold enhancement in the aqueous solubility of indomethacin (poorly water-soluble drug) in 2 M niacinamide solution as compared to its aqueous solubility at 28 ± 1°C.
  
  
  CONCLUSIONS
  The proposed method is new, simple, safe, environmentally friendly, economic, accurate and cost-effective and can be successfully employed in routine analysis.
authors.affiliation: Department of Pharmacy, Industrial Pharmacy Research Laboratory, Shri G. S. Institute of Technology and Science, Indore, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Maheshwari
authors.forename: Amit
authors.initials: A
authors.lastname: Rathore
authors.forename: Archana
authors.initials: A
authors.lastname: Agrawal
authors.forename: Megha A
authors.initials: MA
authors.lastname: Gupta
keywords: Environmentally safe; hydrotropic solubilization; indomethacin; niacinamide; spectrophotometric