title: Immune-complex deposits in pANCA glomerulonephritis: a pediatric case report.
abstract: A 15-year-old boy is admitted to the hospital for clinical signs that suggest a pulmonary-renal syndrome (fever, cough, hemopthoic expectoration, oliguria, gross hematuria). A crescentic pANCA positive glomerulonephritis was configured. However, dense subendothelial deposits were identified in electronic microscopy and immunofluorescence staining showed granular deposits of IgG and C3, kappa and lambda in the capillary loops. Although the treatment was strictly followed, after three years and three months of good clinical state, he manifested signs of kidney failure being transplanted. His case represents a specific pattern of rapidly progressive glomerulonephritis leading to kidney failure and emphasizes the importance of clinical attendance especially in a case of two associated glomerulopathies.
authors.affiliation: Department of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Bălgrădean
authors.forename: Eliza
authors.initials: E
authors.lastname: Cinteză
authors.forename: E
authors.initials: E
authors.lastname: Mandache
mesh_terms: D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism*; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D003937:Diagnosis, Differential; D005921:Glomerulonephritis / Q000276:immunology*; D006470:Hemorrhage / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008171:Lung Diseases / Q000276:immunology; D008297:Male
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G