title: Copper catalyzed β-difluoroacetylation of dihydropyrans and glycals by means of direct C-H functionalization.
abstract: A copper catalyzed direct functionalization of dihydropyrans and glycals has been developed. This method affords a new and straightforward access to C-2-CF2 dihydropyrans and glycosides in a single step starting from readily available starting materials. This new copper based catalytic system, probably involving a Cu(III) species as supported by experiments, allows the formation of the valuable fluorinated glycosides in good yields.
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France.
authors.forename: Marie-Charlotte
authors.initials: MC
authors.lastname: Belhomme
authors.forename: Thomas
authors.initials: T
authors.lastname: Poisson
authors.forename: Xavier
authors.initials: X
authors.lastname: Pannecoucke
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry*
chemical_list: D006027:Glycosides; D006845:Hydrocarbons, Fluorinated; D011714:Pyrans; D003300:Copper