title: Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin.
abstract: Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: Cmax, T1/2(β), Kel and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin.
authors.affiliation: College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan, 712-749, South Korea.
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Kang
authors.forename: Gyu Sub
authors.initials: GS
authors.lastname: Ko
authors.forename: Do Gyeong
authors.initials: DG
authors.lastname: Oh
authors.forename: Jin Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Keumhan
authors.initials: K
authors.lastname: Noh
authors.forename: Wonku
authors.initials: W
authors.lastname: Kang
authors.forename: Won Ki
authors.initials: WK
authors.lastname: Yoon
authors.forename: Hyoung Chin
authors.initials: HC
authors.lastname: Kim
authors.forename: Hye Gwang
authors.initials: HG
authors.lastname: Jeong
authors.forename: Tae Cheon
authors.initials: TC
authors.lastname: Jeong
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005419:Flavonoids / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D064307:Microbiota / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D031363:Scutellaria
chemical_list: D005419:Flavonoids; C038044:baicalin