title: Novel colloidal carriers for psoriasis: current issues, mechanistic insight and novel delivery approaches.
abstract: Psoriasis is an autoimmune disorder of the skin with relapsing episodes of inflammation and hyperkeratosis. Numerous approaches have been explored to treat this dreadful disease using different antipsoriatic drugs with different modes of action and routes of administration. But, till date there is no cure for psoriasis due to lack of an ideal carrier for safe and effective delivery of antipsoriatic drugs. Constant progression in the development of newer formulations utilizing colloidal drug delivery systems has led to effective treatment of psoriasis. Colloidal carriers include vesicular and particulate systems like liposome, transferosome, niosomes, ethosomes, solid lipid nanoparticles, microspheres, micelles, dendrimers etc. have gained unique position as drug cargoes. Present review is an attempt to contemplate on psoriasis in terms of pathogenesis, role of cytokines, major hindrances in psoriasis treatment, currently available treatment options pertaining to mode of action, pharmacokinetics, marketed products, side effects of individual antipsoriatic drugs and recent developments in the delivery of various antipsoriatic drugs through novel colloidal drug carriers.
authors.affiliation: University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh 492010, India.
authors.forename: Madhulika
authors.initials: M
authors.lastname: Pradhan
authors.forename: Deependra
authors.initials: D
authors.lastname: Singh
authors.forename: Manju Rawat
authors.initials: MR
authors.lastname: Singh
mesh_terms: D000818:Animals; D003102:Colloids; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D003102:Colloids; D004337:Drug Carriers; D008055:Lipids; D011108:Polymers
keywords: Antipsoriatic drugs; Colloidal carriers; Cytokines; Nanocolloidal systems; Psoriasis