title: NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
abstract: The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B-cells are particularly dependent on constitutive NF-κB activity, and rapidly undergo apoptosis upon NF-κB blockade. Here, we review LMP1 function, with special attention to current understanding of the molecular mechanisms of LMP1-mediated NF-κB and IRF7 pathway activation. Recent advances include the elucidation of transmembrane motifs important for LMP1 trafficking and ligand-independent signaling, analysis of genome-wide LMP1 gene targets, and the identification of novel cell proteins that mediate LMP1 NF-κB and IRF7 pathway activation.
authors.affiliation: Division of Infectious Disease, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Ina
authors.initials: I
authors.lastname: Ersing
authors.forename: Katharina
authors.initials: K
authors.lastname: Bernhardt
authors.forename: Benjamin E
authors.initials: BE
authors.lastname: Gewurz
mesh_terms: D002472:Cell Transformation, Viral; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000472:pathogenicity; D054884:Host-Pathogen Interactions; D006801:Humans; D050839:Interferon Regulatory Factor-7 / Q000276:immunology*; D016328:NF-kappa B / Q000276:immunology*; D015398:Signal Transduction; D014763:Viral Matrix Proteins / Q000276:immunology*
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; C494234:IRF7 protein, human; D050839:Interferon Regulatory Factor-7; D016328:NF-kappa B; D014763:Viral Matrix Proteins