title: Platelet chemokines in health and disease.
abstract: In recent years, it has become clear that platelets and platelet-derived chemokines, beyond their role in thrombosis and haemostasis, are important mediators affecting a broad spectrum of (patho)physiological conditions. These biologically active proteins are released from α-granules upon platelet activation, most probably even during physiological conditions. In this review, we give a concise overview and an update on the current understanding of platelet-derived chemokines in a context of health and disease.
authors.affiliation: Philipp von Hundelshausen, MD, Institute for Cardiovascular Prevention, Ludwig-Maximilians University (LMU) Munich, Pettenkoferstr. 9, 80336 Munich, Germany, Tel.: +49 89 5160 4359, Fax: +49 89 5160 4352, E-mail: phundels@med.lmu.de.
authors.forename: E
authors.initials: E
authors.lastname: Karshovska
authors.forename: C
authors.initials: C
authors.lastname: Weber
authors.forename: P
authors.initials: P
authors.lastname: von Hundelshausen
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D002450:Cell Communication; D018925:Chemokines / Q000276:immunology*; D006487:Hemostasis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000473:pathology; D015539:Platelet Activation / Q000276:immunology; D013927:Thrombosis / Q000276:immunology*
chemical_list: D018925:Chemokines
keywords: Platelet immunology; atherosclerosis; chemokines; infectious diseases; inflammation