title: Plasmablastic lymphoma of the oral cavity in a human immunodeficiency virus-negative patient: a case report with literature review.
abstract: Plasmablastic lymphoma (PBL) is an aggressive diffuse large B-cell lymphoma variant that is most frequently observed in the oral cavity of human immunodeficiency virus (HIV)-infected individuals. However, in recent years, some cases have emerged in patients without HIV infection and involve other sites like stomach, lung, nasal cavity, and jejunum. We report a rare case of PBL in the maxillary anterior area of a 62-year-old man without HIV infection. The tumor cells were characterized by non-cohesive round or oval shape cells with eccentrically-placed nuclei with a prominent perinuclear halo. Immunohistochemical studies showed that the tumor cells were strongly positive for MUM1, VS38c, VMT, and κ light chain, focally positive for LCA and CD79a, and negative for CD3, CD20, CD56, λ light chain, CK-pan, EMA, and HMB45. The patient was treated with chemotherapy using cyclophosphamide, doxorubicin, vincristine, and prednisone. The lesion showed partial remission.
authors.affiliation: Assistant Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: So-Young
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Fellow, Department of Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
authors.forename: Young-Ah
authors.initials: YA
authors.lastname: Cho
authors.affiliation: Associate Professor, Department of Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
authors.forename: Seong-Doo
authors.initials: SD
authors.lastname: Hong
authors.affiliation: Professor, Department of Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
authors.forename: Jae-Il
authors.initials: JI
authors.lastname: Lee
authors.affiliation: Professor, Department of Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
authors.forename: Sam-Pyo
authors.initials: SP
authors.lastname: Hong
authors.affiliation: Assistant Professor, Department of Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea. Electronic address: enprism1@snu.ac.kr.
authors.forename: Hye-Jung
authors.initials: HJ
authors.lastname: Yoon
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D018023:HIV Seronegativity; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008441:Maxillary Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness