title: Desmoplastic melanoma associated with an intraepidermal lentiginous lesion: case report and literature review.
abstract: Desmoplastic melanoma tends to present as firm, amelanotic papules. Microscopically, it reveals a proliferation of fusiform cells in the dermis and variable collagen deposition, as well as intraepidermal melanocytic proliferation of lentiginous type in most cases. Biopsy in a 61-year-old white male patient, who had received a diagnosis of lentigo maligna on his face 10 years before, revealed a proliferation of dermal pigmented spindle cells and collagen deposition, reaching the deep reticular dermis, with a lentiginous component. Immunohistochemistry with S-100, Melan-A and WT1 showed positivity, but it was weak with HMB45. Desmoplastic melanoma associated with lentigo maligna was diagnosed. Several authors discuss whether desmoplastic melanoma represents a progression from the lentiginous component or arises "de novo". Desmoplastic melanoma represents a minority of cases of primary cutaneous melanoma (less than 4%). Identification of lentigo maligna indicates that desmoplastic melanoma should be carefully investigated.
authors.affiliation: Hospital Naval Marcílio Dias (HNMD) – Rio de Janeiro (RJ), Brazil. cesar.548@gmail.com
authors.forename: Cesar de Souza
authors.initials: Cde S
authors.lastname: Bastos Junior
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Piñeiro-Maceira
authors.forename: Fernando Manuel Belles de
authors.initials: FM
authors.lastname: Moraes
mesh_terms: D001706:Biopsy; D005153:Facial Neoplasms / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000737:chemistry / Q000473:pathology; D058965:MART-1 Antigen / Q000032:analysis; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D025721:WT1 Proteins / Q000032:analysis
chemical_list: D058965:MART-1 Antigen; D009418:S100 Proteins; D025721:WT1 Proteins