title: In vivo assessment of human brain oscillations during application of transcranial electric currents.
abstract: Brain oscillations reflect pattern formation of cell assemblies' activity, which is often disturbed in neurological and psychiatric diseases like depression, schizophrenia and stroke. In the neurobiological analysis and treatment of these conditions, transcranial electric currents applied to the brain proved beneficial. However, the direct effects of these currents on brain oscillations have remained an enigma because of the inability to record them simultaneously. Here we report a novel strategy that resolves this problem. We describe accurate reconstructed localization of dipolar sources and changes of brain oscillatory activity associated with motor actions in primary cortical brain regions undergoing transcranial electric stimulation. This new method allows for the first time direct measurement of the effects of non-invasive electrical brain stimulation on brain oscillatory activity and behavior.
authors.affiliation: Human Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive, Building 10, Bethesda, Maryland 20892, USA. surjo.soekadar@uni-tuebingen.de
authors.forename: Surjo R
authors.initials: SR
authors.lastname: Soekadar
authors.forename: Matthias
authors.initials: M
authors.lastname: Witkowski
authors.forename: Eliana G
authors.initials: EG
authors.lastname: Cossio
authors.forename: Niels
authors.initials: N
authors.lastname: Birbaumer
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Robinson
authors.forename: Leonardo G
authors.initials: LG
authors.lastname: Cohen
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004558:Electric Stimulation / Q000379:methods*; D004560:Electricity; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography; D008297:Male; D009043:Motor Activity; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted