title: In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus.
abstract: OBJECTIVE
  To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis.
  
  
  METHODS
  The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis (M. philippinensis) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus (E. granulosus), under in-vitro conditions with reference to the known standard drug Praziquantel®.
  
  
  RESULTS
  At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation.
  
  
  CONCLUSIONS
  As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects.
authors.affiliation: Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
authors.forename: Mayank
authors.initials: M
authors.lastname: Gangwar
authors.forename: Vijay C
authors.initials: VC
authors.lastname: Verma
authors.forename: Tryambak D
authors.initials: TD
authors.lastname: Singh
authors.forename: Sushil K
authors.initials: SK
authors.lastname: Singh
authors.forename: R K
authors.initials: RK
authors.lastname: Goel
authors.forename: Gopal
authors.initials: G
authors.lastname: Nath
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay; D048209:Echinococcus granulosus / Q000187:drug effects*; D005638:Fruit / Q000737:chemistry*; D036461:Mallotus Plant / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011223:Praziquantel / Q000494:pharmacology; D016019:Survival Analysis
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts; D011223:Praziquantel