title: Cytokines related to MMP-11 expression by inflammatory cells and breast cancer metastasis.
abstract: Breast tumors infiltrated by matrix metalloprotease 11 (MMP-11)+mononuclear inflammatory cells are prone to form metastases; express high levels of interleukin (IL)-1, IL-5, IL-6, IL-17, interferon β (IFNβ) and NFκB; and exhibit an increased CD68+/(CD3+CD20+) cell ratio at their invasive front. These factors, which are implicated in the crosstalk between tumors and their inflammatory microenvironment, may emerge as attractive prognostic factors and therapeutic targets.
authors.affiliation: Unidad de Investigación; Fundación Hospital de Jove; Gijón, Asturias, Spain.
authors.forename: Noemi
authors.initials: N
authors.lastname: Eiró
authors.forename: Belen
authors.initials: B
authors.lastname: Fernandez-Garcia
authors.forename: Luis O
authors.initials: LO
authors.lastname: González
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Vizoso
keywords: inflammation; interleukins; matrix metalloprotease 11; metastasis