title: Forkhead box proteins: tuning forks for transcriptional harmony.
abstract: Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers.
authors.affiliation: Department of Surgery and Cancer, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. eric.lam@imperial.ac.uk
authors.forename: Eric W-F
authors.initials: EW
authors.lastname: Lam
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Brosens
authors.forename: Ana R
authors.initials: AR
authors.lastname: Gomes
authors.forename: Chuay-Yeng
authors.initials: CY
authors.lastname: Koo
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D051858:Forkhead Transcription Factors / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000209:etiology* / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D051858:Forkhead Transcription Factors