title: Balloon liver cells forming Mallory-Denk-bodies are progenitor cells.
abstract: Previous studies on both human and mice livers showed MDB formation in both drug hepatitis and hepatocellular carcinoma. Using the drug hepatitis mouse model of MDB formation, numerous markers for progenitor cells were found in the cells forming MDBs. In current study, using the drug hepatitis mouse model, we found that the MDB forming cells expressed two additional progenitor cell markers. These markers were CD49f and TLR4.
authors.affiliation: Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90509, USA. sfrench@labiomed.org
authors.forename: S W
authors.initials: SW
authors.lastname: French
authors.forename: E
authors.initials: E
authors.lastname: Vitocruz
authors.forename: B A
authors.initials: BA
authors.lastname: French
mesh_terms: D016022:Case-Control Studies; D006519:Hepatitis, Alcoholic / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D039423:Integrin alpha1 / Q000378:metabolism; D008099:Liver / Q000166:cytology* / Q000473:pathology; D059609:Mallory Bodies; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology; D051197:Toll-Like Receptor 4 / Q000378:metabolism
chemical_list: D039423:Integrin alpha1; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4
keywords: Integrin alpha 6 (CD49f); Mallory–Denk bodies (MDBs); Progenitor cells; Toll-like receptor 4 (TLR4); Tumor-initiating stem-like cells (TISC)