title: Diabetic nephropathy: a national dialogue.
abstract: The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue (KRND) asked the scientific community to formulate and prioritize research objectives that would improve our understanding of kidney function and disease. Several high-priority objectives for diabetic nephropathy were identified in data and sample collection, hypothesis generation, hypothesis testing, and translation promotion. The lack of readily available human samples linked to comprehensive phenotypic, clinical, and demographic data remains a significant obstacle. With data and biological samples in place, several possibilities exist for using new technologies to develop hypotheses. Testing novel disease mechanisms with state-of-the-art tools should continue to be the foundation of the investigative community. Research must be translated to improve diagnosis and treatment of people. The objectives identified by the KRND provide the research community with future opportunities for improving the prevention, diagnosis, and treatment of diabetic nephropathy.
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 6707 Democracy Boulevard, Bethesda, MD 20892, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Breyer
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Coffman
authors.forename: Michael F
authors.initials: MF
authors.lastname: Flessner
authors.forename: Linda F
authors.initials: LF
authors.lastname: Fried
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Harris
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Ketchum
authors.forename: Matthias
authors.initials: M
authors.lastname: Kretzler
authors.forename: Robert G
authors.initials: RG
authors.lastname: Nelson
authors.forename: John R
authors.initials: JR
authors.lastname: Sedor
authors.forename: Katalin
authors.initials: K
authors.lastname: Susztak
mesh_terms: D000818:Animals; D018070:Biological Specimen Banks; D015415:Biomarkers; D035843:Biomedical Research; D003625:Data Collection; D003928:Diabetic Nephropathies / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology; D054586:National Institute of Diabetes and Digestive and Kidney Diseases (U.S.); D012107:Research Design; D014481:United States
chemical_list: D015415:Biomarkers