title: Transfer of perfluorooctane sulfonic acid (PFOS) from contaminated feed to dairy milk.
abstract: Dietary intake is the predominant route for human exposure to perfluorooctane sulfonic acid (PFOS). Single pollution events may thus affect human exposure if polluted ground and water is used to produce animal feed or food. In this study, a physiologically based pharmacokinetic (PBPK-) model is derived that describes the uptake of PFOS from contaminated feed by cows and its subsequent elimination through the cows' milk. Parameter values of the model were estimated by fitting to experimental data of a cow feeding trial. Model calculations showed that almost all PFOS ingested is excreted through the cows' milk. The elimination rate, however, was low as the estimated half-life in the cow was 56days and it may, thus, take a long time after an initial pollution event to produce PFOS-free milk. The derived model can be used to estimate the transfer of PFOS through the dairy food chain and can be used for comparison of various contamination routes.
authors.affiliation: RIKILT, Wageningen University and Research Centre, P.O. Box 230, 6700 AE Wageningen, The Netherlands. esther.vanasselt@wur.nl
authors.forename: E D
authors.initials: ED
authors.lastname: van Asselt
authors.forename: J
authors.initials: J
authors.lastname: Kowalczyk
authors.forename: J C H
authors.initials: JC
authors.lastname: van Eijkeren
authors.forename: M J
authors.initials: MJ
authors.lastname: Zeilmaker
authors.forename: S
authors.initials: S
authors.lastname: Ehlers
authors.forename: P
authors.initials: P
authors.lastname: Fürst
authors.forename: M
authors.initials: M
authors.lastname: Lahrssen-Wiederholt
authors.forename: H J
authors.initials: HJ
authors.lastname: van der Fels-Klerx
mesh_terms: D017738:Alkanesulfonic Acids / Q000737:chemistry* / Q000378:metabolism; D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D003257:Consumer Product Safety; D004785:Environmental Pollutants / Q000737:chemistry* / Q000378:metabolism; D005466:Fluorocarbons / Q000737:chemistry* / Q000378:metabolism; D005506:Food Contamination / Q000032:analysis*; D006207:Half-Life; D006801:Humans; D008892:Milk / Q000737:chemistry* / Q000378:metabolism
chemical_list: D017738:Alkanesulfonic Acids; D004785:Environmental Pollutants; D005466:Fluorocarbons; C076994:perfluorooctane sulfonic acid