title: Selective cleavage of 3,5-bis-(trifluoromethyl)benzylcarbamate by SmI2-Et3N-H2O.
abstract: A novel electron poor protection group for amines has been developed. It undergoes rapid cleavage by SmI2-Et3N-H2O and its orthogonality towards the regular benzyl carbamate group (CBz) under reductive or transfer hydrogenolytic conditions is reported.
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Tobias
authors.initials: T
authors.lastname: Ankner
authors.forename: Anna Said
authors.initials: AS
authors.lastname: Stålsmeden
authors.forename: Göran
authors.initials: G
authors.lastname: Hilmersson
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002219:Carbamates / Q000737:chemistry*; D005021:Ethylamines / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D012493:Samarium / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000588:Amines; D002219:Carbamates; D005021:Ethylamines; D007454:Iodides; D014867:Water; D012493:Samarium; C409809:samarium diiodide; C016162:triethylamine