title: Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities.
abstract: Lactoferrin (Lf), the main iron-binding protein of milk, has biological activities. We have evaluated the potential of camel milk lactoferrin for its ability to inhibit the proliferation of the colon cancer cell line, HCT-116, in vitro, DNA damage and its antioxidant activities for the first time. The antioxidant capacity of Lf was evaluated by different assays, including ferric-reducing/antioxidant power assay (FRAP), free radical-scavenging activity (DPPH), nitric oxide (NO) radical-scavenging assay, total antioxidant activity and DNA damage, compared with vitamin C and rutin.
authors.affiliation: Department of Nutrition and Health, College of Food and Agriculture, United Arab Emirates University, P.O. Box 15551, Al Ain, United Arab Emirates. hosamh@uaeu.ac.ae
authors.forename: Hosam M
authors.initials: HM
authors.lastname: Habib
authors.forename: Wissam H
authors.initials: WH
authors.lastname: Ibrahim
authors.forename: Regine
authors.initials: R
authors.lastname: Schneider-Stock
authors.forename: Hassan M
authors.initials: HM
authors.lastname: Hassan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002162:Camelus; D049109:Cell Proliferation / Q000187:drug effects*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology*; D004249:DNA Damage / Q000187:drug effects*; D015536:Down-Regulation / Q000187:drug effects; D045325:HCT116 Cells; D006801:Humans; D007781:Lactoferrin / Q000737:chemistry / Q000494:pharmacology*; D008892:Milk / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D007781:Lactoferrin