title: [Molecular biology of bone metastases].
abstract: Bone metastases are a frequent and devastating complication in cancer patients. Recently, significant advances in our understanding of the molecular mechanisms responsible for both osteolytic and osteoblastic bone metastases have occurred. The use of OMICS and the availability of appropriate preclinical animal models of bone metastasis have permitted the identification of factors produced by the tumor or by the host stroma in response to the tumor. These types of studies should result in a decrease of the serious skeletal morbidities associated with metastatic prostate cancer and may in the future improve overall survival. In this review the next generation of molecular targets in bone metastasis will be summarized.
authors.affiliation: Programa de Investigación Traslacional en Cáncer de Próstata Vall d'Hebrón, Hospital Vall d'Hebrón. Barcelona, España. andreas.doll@vhir.org
authors.forename: Andreas
authors.initials: A
authors.lastname: Doll
authors.forename: Marta
authors.initials: M
authors.lastname: García
authors.forename: Marina
authors.initials: M
authors.lastname: Rigau
authors.forename: Mireia
authors.initials: M
authors.lastname: Olivan
authors.forename: Melania
authors.initials: M
authors.lastname: Montes
authors.forename: Tamara
authors.initials: T
authors.lastname: Sequeiros
authors.forename: Marta
authors.initials: M
authors.lastname: Llaurado
authors.forename: Eva
authors.initials: E
authors.lastname: Colás
authors.forename: Jaume
authors.initials: J
authors.lastname: Reventós
authors.forename: Juan
authors.initials: J
authors.lastname: Morote
mesh_terms: D000818:Animals; D015415:Biomarkers; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008967:Molecular Biology; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology
chemical_list: D015415:Biomarkers