title: [Diastolic dysfunction in the elderly subjects. Disease or a physiological manifestation of ageing?].
abstract: OBJECTIVE
  The purpose of this summary paper is to discuss the current knowledge of the impact of age on diastolic function of the left ventricle. Data from the literature: Reports published till this time have convincingly demonstrated a significant relationship of age to diastolic function of the left ventricle. Ageing is a physiological process accompanied by structural changes in both myocardium and arterial bed resulting in worsening of parameters characterizing the left ventricular diastolic function. This "physiological" diastolic dysfunction in the elderly subjects can be explained by the deterioration of passive left ventricular filling properties and by worsening of left ventricular relaxation. The detailed analysis of published reports shows problems in distiguishing this "physiological" diastolic dysfunction resulting from physiological tissue ageing from "pathological" diastolic dysfunction reflecting a disease of cardiovascular system.
  
  
  CONCLUSIONS
  To interprete correctly values of parameters quantifying diastolic function of the left ventricle, one should take into account the age of subjects under the examination. Further studies are necessary to distinguish exactly "physiological" deterioration of diastolic function associated with ageing from really "pathological" diastolic dysfunction in the elderly subjects.
authors.affiliation: Interni kardio-angiologicka klinika Lekarske fakulty MU a FN u sv. Anny Brno. jaroslav.meluzin@fnusa.cz
authors.forename: J
authors.initials: J
authors.lastname: Meluzín
authors.forename: H
authors.initials: H
authors.lastname: Podroužková
authors.forename: Z
authors.initials: Z
authors.lastname: Gregorová
authors.forename: R
authors.initials: R
authors.lastname: Panovský
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*