title: Effect of dietary cholesterol and cholesterol oxides on blood cholesterol, lipids, and the development of atherosclerosis in rabbits.
abstract: Two studies were conducted to determine the effects of dietary cholesterol (CHO) and cholesterol oxides (COPs) on the development of atherosclerosis and the changes in fatty acid and blood characteristics in rabbits. In the first study, forty male New Zealand white rabbits were divided into 5 groups and fed commercial rabbit chow with no added CHO or COPs, 1 g CHO, 0.9 g CHO + 0.1 g COPs, 0.8 g CHO + 0.2 g COPs, or 0.5 g CHO + 0.5 g COPs per kg diet. In the second study, 24 male New Zealand White rabbits were divided into 3 groups and fed a diet containing 2 g CHO, 1.6 g CHO + 0.4 g COPs, or 1.2 g CHO + 0.8 g COPs per kg diet. All diets induced atherosclerotic lesions in the rabbits' ascending thoracic aorta. The serum CHO and triglyceride levels (p < 0.05) increased significantly with the increased levels of CHO in the diets. Dietary CHO or COPs did not influence high-density lipoprotein CHO levels. The ratio of saturated fatty acid to unsaturated fatty acid increased as the level of dietary CHO and COPs increased.
authors.affiliation: Department of Bioresources and Food Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Korea. duahn@iastate.edu.
authors.forename: Sun Jin
authors.initials: SJ
authors.lastname: Hur
authors.forename: Byungrok
authors.initials: B
authors.lastname: Min
authors.forename: Ki Chang
authors.initials: KC
authors.lastname: Nam
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Lee
authors.forename: Dong Uk
authors.initials: DU
authors.lastname: Ahn
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology*; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D003331:Coronary Vessels / Q000473:pathology; D004910:Erythrocyte Membrane / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL; D008297:Male; D010087:Oxides / Q000378:metabolism*; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D005227:Fatty Acids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010087:Oxides; D014280:Triglycerides; D002784:Cholesterol