title: Identification of a methicillin-resistant Staphylococcus aureus inhibitory compound isolated from Serratia marcescens.
abstract: In this study, we identified an antimicrobial compound produced by the Gram-negative bacterium Serratia marcescens. Colonies of S. marcescens inhibited the growth of nine different methicillin-resistant Staphylococcus aureus (MRSA) isolates and several other tested Gram-positive bacterial species, but not Gram-negative bacteria. Genetic analysis revealed the requirement for the swrW gene which codes for a non-ribosomal peptide synthetase that generates the cyclodepsipeptide antibiotic serratamolide, also known as serrawettin W1. This is the first report describing the anti-MRSA properties of serratamolide.
authors.affiliation: Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA. Electronic address: kadourde@umdnj.edu.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Kadouri
authors.forename: Robert M Q
authors.initials: RM
authors.lastname: Shanks
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism; D012706:Serratia marcescens / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase
keywords: Aminolipid; Antibiotic; MRSA; Non-ribosomal peptide synthetase; Nosocomial infection; Secondary metabolite