title: Etiology of acute pyelonephritis: species composition and populational levels of urine microflora.
abstract: Acute urinary tract infection is considered to be a growing burden in both medical and socio-economic terms. The exact etiologic structure of acute pyelonephritis pathogens, their role and interference is unclear. Thus, we aimed on revealing the species composition and populational levels of microorganisms causing acute inflammation of kidney and perirenal tissues. The study included 145 patients with acute pyelonephritis (mean age 34.15±6.79); 67 (47.2%) male and 78 (53.8%) female. Microbiota was defined in three different portions (samples) of urine taken during on urination. Species were considered as dominant when constancy index was 50.0% or higher, additional - from 25.0% to 50.0% and random species if value less than 25.0%. Received data expectedly correlates with other studies. Conditionally pathogenic Enterobacteriaceae play major role in etiology of acute pyelonephritis. Our study provides further evidence of higher etiologic significance of conditionally pathogenic flora (normal E. coli) over of the traditional pathogenic microorganisms like enteropathogenic Escherichia and Staphylococcus aureus.
authors.forename: V T
authors.initials: VT
authors.lastname: Stepan
authors.forename: O S
authors.initials: OS
authors.lastname: Fedoruk
authors.forename: L P
authors.initials: LP
authors.lastname: Sidorchuk
authors.forename: V V
authors.initials: VV
authors.lastname: Vozniuk
authors.forename: R I
authors.initials: RI
authors.lastname: Sidorchuk
mesh_terms: D000328:Adult; D004755:Enterobacteriaceae / Q000302:isolation & purification / Q000472:pathogenicity; D004926:Escherichia coli / Q000302:isolation & purification / Q000472:pathogenicity; D005260:Female; D006801:Humans; D008297:Male; D064307:Microbiota; D011704:Pyelonephritis / Q000382:microbiology* / Q000473:pathology / Q000652:urine*; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology / Q000652:urine; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity; D014552:Urinary Tract Infections / Q000382:microbiology* / Q000473:pathology / Q000652:urine*