title: Easy design of colorimetric logic gates based on nonnatural base pairing and controlled assembly of gold nanoparticles.
abstract: Utilizing the principles of metal-ion-mediated base pairs (C-Ag-C and T-Hg-T), the pH-sensitive conformational transition of C-rich DNA strand, and the ligand-exchange process triggered by DL-dithiothreitol (DTT), a system of colorimetric logic gates (YES, AND, INHIBIT, and XOR) can be rationally constructed based on the aggregation of the DNA-modified Au NPs. The proposed logic operation system is simple, which consists of only T-/C-rich DNA-modified Au NPs, and it is unnecessary to exquisitely design and alter the DNA sequence for different multiple molecular logic operations. The nonnatural base pairing combined with unique optical properties of Au NPs promises great potential in multiplexed ion sensing, molecular-scale computers, and other computational logic devices.
authors.affiliation: Department of Chemistry, Nanchang University, Nanchang 330031, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhong-Xia
authors.initials: ZX
authors.lastname: Wang
authors.forename: Ru-Ping
authors.initials: RP
authors.lastname: Liang
authors.forename: Jian-Ding
authors.initials: JD
authors.lastname: Qiu
mesh_terms: D020029:Base Pairing; D003124:Colorimetry; D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry*; D004229:Dithiothreitol / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D008128:Logic; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D036103:Nanotechnology
chemical_list: D006046:Gold; D004247:DNA; D004229:Dithiothreitol