title: Evaluation of neointimal coverage in patients with coronary artery aneurysm formation after drug-eluting stent implantation by optical coherence tomography.
abstract: BACKGROUND
  The vessel healing in patients with coronary artery aneurysms (CAA) that form after drug-eluting stent (DES) implantation is not clear. This study aims to assess the vessel healing in patients with CAA formation after DES implanation.
  
  
  METHODS
  From June 2008 to August 2011, follow-up coronary angiography was conducted on 1160 patients who underwent percutaneous coronary intervention (PCI). The average period of follow-up was about (18.95 ± 13.05) months. A total of 175 patients who underwent DES implantation into de novo lesions and who underwent coronary angiography and optical coherence tomography (OCT) examination during follow-up were identified. Patients were divided into the CAA group (n = 31) and non-CAA group (n = 144) based on the results of the coronary angiography. The cardiac events including angina and acute myocardial infarction were noted; in addition, the neointimal thickness and the frequency of strut malapposition and strut uncoverage were also noted.
  
  
  RESULTS
  A greater proportion of incomplete neointimal coverage (17.17% vs. 1.90%, P < 0.001) and strut malapposition (18.20% vs. 1.38%, P < 0.001) were observed in the CAA group. The neointimal thickness in the CAA group was significantly thinner than that in the non-CAA group ((146.6 ± 94.8) µm vs. (192.5 ± 97.1) µm, P < 0.001), as detected via OCT. Patients with CAA formation had a higher frequency of cardiac events including angina pectoris (25.81% vs. 6.25%, P = 0.001) and acute myocardial infarction (9.68% vs. 0.13%, P = 0.002) and thrombosis (16.13% vs. 0.69%, P < 0.001). The longitudinal length of the CAA in the cardiac event group was significantly longer than in the no cardiac event group ((20.0 ± 9.07) mm vs. (12.05 ± 5.38) mm, P = 0.005).
  
  
  CONCLUSIONS
  CAA formation after DES implantation is frequently associated with cardiac events as a result of stent malapposition and incomplete neointimal coverage.
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Tian
authors.forename: Yun-dai
authors.initials: YD
authors.lastname: Chen
authors.forename: Lian
authors.initials: L
authors.lastname: Chen
authors.forename: Zhi-jun
authors.initials: ZJ
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.forename: Qin-hua
authors.initials: QH
authors.lastname: Jin
authors.forename: Chang-fu
authors.initials: CF
authors.lastname: Liu
authors.forename: Jin-da
authors.initials: JD
authors.lastname: Wang
authors.forename: Hong-bin
authors.initials: HB
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D003323:Coronary Aneurysm / Q000175:diagnosis*; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D058426:Neointima / Q000175:diagnosis*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D041623:Tomography, Optical Coherence / Q000379:methods*