title: Continuous infusion meropenem and ticarcillin-clavulanate in pediatric cystic fibrosis patients.
abstract: Aztreonam, cefepime, and ceftazidime are anti-pseudomonal beta-lactam antibiotics which have been previously reported to be administered by continuous infusion (CI) in pediatric CF patients. We present two cases administering intravenous (IV) meropenem and ticarcillin-clavulanate by CI in pediatric CF patients. The delivery of beta-lactam antibiotics via CI should be considered in order to optimize the pharmacodynamics (PD) of beta-lactams in the treatment of acute pulmonary exacerbations (APE).
authors.affiliation: Department or Pharmacy, Intermountain Primary Children's Medical Center, Salt Lake City, Utah; Intermountain Cystic Fibrosis Pediatric Center, Salt Lake City, Utah.
authors.forename: Jeffery T
authors.initials: JT
authors.lastname: Zobell
authors.forename: Christina
authors.initials: C
authors.lastname: Ferdinand
authors.forename: David C
authors.initials: DC
authors.lastname: Young
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002969:Clavulanic Acids / Q000008:administration & dosage; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D000077731:Meropenem; D018410:Pneumonia, Bacterial / Q000150:complications / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D012244:Rhodospirillaceae / Q000302:isolation & purification; D013845:Thienamycins / Q000008:administration & dosage*; D013982:Ticarcillin / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D013845:Thienamycins; C043215:ticarcillin-clavulanic acid; D013982:Ticarcillin; D000077731:Meropenem
keywords: Inquilinus limosus; Pseudomonas aeruginosa; antibiotics; beta-lactams