title: Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions.
abstract: This work investigates the flocculation effect of polyethylene glycol (PEG) on typical aqueous dispersions, such as O/W emulsions and solid/liquid suspensions. Hereby, sunflower oil and flubendazole were selected as model ingredients, whereas microfluidization at variable driving air pressure was used to enable particle size distribution variations for both systems. The molecular weight of PEG varied from 2000 to 12,000g/mol while its concentration ranged from 50 to 100mg/ml. Statistical analysis revealed that both PEG concentration and molecular weight showed a flocculation enhancing effect. Hereby the inhibiting effect of particle size toward the formation of voluminous and easily resuspendable sediment could at least partially be overcome by selecting appropriate PEG characteristics.
authors.affiliation: Particle and Interfacial Technology Group, Ghent University, Coupure Links 653, B-9000 Gent, Belgium.
authors.forename: Wuxin
authors.initials: W
authors.lastname: Zhu
authors.forename: Lien
authors.initials: L
authors.lastname: Vermeir
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Govoreanu
authors.forename: Katrien
authors.initials: K
authors.lastname: Verbruggen
authors.forename: Tina
authors.initials: T
authors.lastname: Ariën
authors.forename: Paul
authors.initials: P
authors.lastname: Van der Meeren
mesh_terms: D002626:Chemistry, Pharmaceutical; D004655:Emulsions; D005427:Flocculation; D008463:Mebendazole / Q000031:analogs & derivatives / Q000737:chemistry; D008970:Molecular Weight; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D025341:Principal Component Analysis; D012044:Regression Analysis; D000074242:Sunflower Oil; D013535:Suspensions; D014783:Viscosity
chemical_list: D004655:Emulsions; D010938:Plant Oils; D000074242:Sunflower Oil; D013535:Suspensions; D011092:Polyethylene Glycols; D008463:Mebendazole; C018945:flubendazole
keywords: Emulsion; Flocculation; Flubendazole suspension; Polyethylene glycol; Resuspendability; Sedimentation