title: Alcohol assisted C-C bond breaking: copper-catalyzed deacetylative α-arylation of β-keto esters and amides.
abstract: A method of alcohol-assisted copper-catalyzed highly selective deacetylative α-arylation of β-keto esters and amides has been demonstrated, which illustrated an efficient example of achieving α-aryl esters and amides. From the synthetic point of view, this arylation protocol is general and practical, representing a simple way to produce α-arylated carbonyl compounds from basic starting materials at low cost.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, Hubei, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ke
authors.forename: Chuan
authors.initials: C
authors.lastname: He
authors.forename: Huiying
authors.initials: H
authors.lastname: Liu
authors.forename: Huan
authors.initials: H
authors.lastname: Xu
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
mesh_terms: D000107:Acetylation; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*
chemical_list: D000577:Amides; D004952:Esters; D006841:Hydrocarbons, Aromatic; D003300:Copper