title: Targeted therapies in the treatment of advanced hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is the most common liver cancer and the third leading cause of cancer death. It has been a major worldwide health problem with more new cases being diagnosed each year. The current available therapies for patients with advanced HCC are extremely limited. Therefore, it is of great clinical interests to develop more effective therapies for systemic treatment of advanced HCC. Several promising target-based drugs have been tested in a number of clinical trials. One breakthrough of these efforts is the approved clinical use of sorafenib in patients with advanced HCC. Targeted therapies are becoming an attractive option for the treatment of advanced HCC. In this review, we summarize the most recent progress in clinical targeted treatments of advanced HCC.
authors.affiliation: Division of Surgical Research, Department of Surgery, Cooper University Hospital and Cooper Medical School of Rowan University, Camden, NJ.
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Wei
authors.forename: Cataldo
authors.initials: C
authors.lastname: Doria
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
keywords: hepatocellular carcinoma (HCC); signaling pathway; sorafenib; targeted therapy; tumor inhibitor