title: Regulation and function of pyruvate kinase M2 in cancer.
abstract: Altered metabolism is fundamental to the growth and survival of cancer cells. Pyruvate kinase M2 (PKM2), a key enzyme in cancer metabolism, has been demonstrated to play a central role not only in metabolic reprogramming but also in direct regulation of gene expression and subsequent cell cycle progression. This review outlines the current understanding of PKM2 protein kinase activity and regulatory mechanisms underlying PKM2 expression, enzymatic activity, and nuclear localization, thus highlighting PKM2 as a potential therapeutic target.
authors.affiliation: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: weiweiyang@sibcb.ac.cn.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Yang
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Lu
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004789:Enzyme Activation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D021381:Protein Transport; D011770:Pyruvate Kinase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D011494:Protein Kinases; D011770:Pyruvate Kinase
keywords: Gene expression; PKM2; The Warburg effect