title: VEGF, PIGF and HIF-1α in placentas of early- and late-onset pre-eclamptic patients.
abstract: OBJECTIVE
  The aim of this study was to compare the VEGF, PIGF, and HIF-1α levels in the placentas of early- and late-onset pre-eclamptic patients, which are thought to be important in pathophysiology of pre-eclampsia.
  
  
  METHODS
  Pre-eclamptic early-onset (n = 22) and late-onset (n = 24) pregnant women and a control group of healthy pregnant women (n = 22) were recruited for this case-control study. A semi-quantitative immunohistochemical analysis of VEGF, PIGF and HIF-1α was performed in cross-sections of the placentas of the subjects, after which results were compared.
  
  
  RESULTS
  Levels of VEGF and PIGF in the placentas of pre-eclamptic patients were found to be lower than the levels in the placentas of healthy pregnant women (p < 0.001 and p = 0.025, respectively), whereas the levels of HIF-1α were found significantly higher (p < 0.001). No difference was observed in terms of VEGF, PIGF and HIF-1α in a comparison of the early- and late-onset pre-eclampsia groups (p > 0.05).
  
  
  CONCLUSIONS
  The results of the study indicated that there is no relationship between the time of onset of pre-eclampsia and the placental changes that occur in these factors.
authors.affiliation: Department of Obstetrics and Gynecology, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey. sdemircansezer@gmail.com
authors.forename: Selda Demircan
authors.initials: SD
authors.lastname: Sezer
authors.forename: Mert
authors.initials: M
authors.lastname: Küçük
authors.forename: Firuzan Kaçar
authors.initials: FK
authors.lastname: Döger
authors.forename: Hasan
authors.initials: H
authors.lastname: Yüksel
authors.forename: Ali Rıza
authors.initials: AR
authors.lastname: Odabaşi
authors.forename: Münevver Kaynak
authors.initials: MK
authors.lastname: Türkmen
authors.forename: Bilin Çetinkaya
authors.initials: BÇ
authors.lastname: Cakmak
authors.forename: Imran Kurt
authors.initials: IK
authors.lastname: Ömürlü
authors.forename: Murat Gökhan
authors.initials: MG
authors.lastname: Kinaş
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000378:metabolism*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D055815:Young Adult
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C000608036:PGF protein, human; D011257:Pregnancy Proteins; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor