title: Anti-inflammatory effect of the serratiopeptidase--rationale or fashionable: a study in rat paw oedema model induced by the carrageenan.
abstract: BACKGROUND
  Many drugs, including serratiopeptidases, are marketed without proven efficacy in clinical trials. It is protein in nature and claimed to be effective orally.
  
  
  METHODS
  24 albino wistar rats, 6 each in following groups were assigned--(1) Control group (distilled water, orally) (2) Diclofenac (6.75 mg/kg, IP) (3) serratiopeptidase (5.4 mg/kg, orally) (4) Combination of serratiopeptidase (5.4 mg/kg, orally) and diclofenac (2.25 mg/kg, IP). Inflammatory agent, carrageenan (0.1 ml of 1% w/v) was injected subcutaneously in the ether anesthetized rat hind paw, half an hour after the administration of drug. Rat paw volume up to lateral malleolar process was recorded with plethysmometer at various time periods.
  
  
  RESULTS
  Percentage formation and inhibition of oedema in serratiopeptidase or combination groups were not significantly different than control group. Both were significantly less for diclofenac group.
  
  
  CONCLUSIONS
  Serratiopeptidase was not effective in this animal model of oedema/inflammation.
authors.affiliation: Department of Pharmacology, TNMC & BYL Nair Charitable hospital, Mumbai. drkalpesh03@gmail.com
authors.forename: Kalpesh K
authors.initials: KK
authors.lastname: Joshi
authors.forename: Rajan P
authors.initials: RP
authors.lastname: Nerurkar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use; D016527:Drug Costs; D004359:Drug Therapy, Combination; D004487:Edema / Q000188:drug therapy*; D005121:Extremities; D005260:Female; D008297:Male; D010447:Peptide Hydrolases / Q000008:administration & dosage / Q000191:economics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D004008:Diclofenac; D002351:Carrageenan; D010447:Peptide Hydrolases; C022640:serratiopeptidase