title: Transformation of strictosamide to vincoside lactam by acid catalysis.
abstract: OBJECTIVE
  To identify the structure of the acid-catalyzed product of strictosamide and explore the reaction mechanism.
  
  
  METHODS
  The acid-catalyzed reaction process of strictosamide was monitored by HPLC, and a macroporous resin was used to purify the reaction solution. The structure of the product was confirmed by MS, NMR, and ROESY spectra.
  
  
  RESULTS
  The acid-catalyzed transformation yield from strictosamide to vincoside lactam was 52%.
  
  
  CONCLUSIONS
  The reaction mechanism of the transformation from strictosamide to vincoside lactam may be related to the stability of the three-dimensional configuration of the compound. These results offer a new way to obtain vincoside lactam from the widely distributed indole alkaloid strictosamide by acid-catalysis.
authors.affiliation: Jiangsu Zeukov Pharmaceutical S & T. Inc, Nanjing 210017, China.
authors.forename: Zhao-Qing
authors.initials: ZQ
authors.lastname: Meng
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Liu
authors.forename: Zan
authors.initials: Z
authors.lastname: Li
authors.forename: Yun-Wei
authors.initials: YW
authors.lastname: Lin
authors.forename: Meng-Xuan
authors.initials: MX
authors.lastname: Li
authors.forename: Shi-Ying
authors.initials: SY
authors.lastname: An
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.forename: Jin-Yi
authors.initials: JY
authors.lastname: Xu
mesh_terms: D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D014748:Vinca Alkaloids / Q000737:chemistry*
chemical_list: D000143:Acids; D007769:Lactams; D014748:Vinca Alkaloids; C539462:strictosamide