title: Aerobic training (AT) is more effective than aerobic plus resistance training (AT+RT) to improve anorexigenic/orexigenic factors in obese adolescents.
abstract: BACKGROUND
  The regulation of energy balance is influenced by physical exercise. Although some studies show a stimulation of hormones related to food intake, others show that exercise provides satiety.
  
  
  OBJECTIVE
  The aim of this study was to compare the effects of aerobic training (AT) and aerobic plus resistance training (AT+RT) on anorexigenic and orexigenic factors in obese adolescents undergoing interdisciplinary weight loss therapy.
  
  
  METHODS
  A total of 26 obese adolescents, aged 15-19 years with BMI≥P95 were submitted to 12 months of interdisciplinary intervention (clinical support, nutrition, psychology and physical exercise) and divided into two groups, aerobic training (AT) (n=13) or aerobic plus resistance training (AT+RT) (n=13), which were matched according to gender and body mass. Blood samples were collected to analyze orexigenic factors (AgRP, NPY, MCH) and the anorexigenic factor alpha-MSH.
  
  
  RESULTS
  The AT and AT+RT groups significantly reduced body mass, body mass index and body fat mass (kg) during the therapy. The AT group showed no significant changes in body lean mass (kg), whereas the AT+RT group showed an increase in body lean mass (kg) during the interdisciplinary intervention. There was an increase in AgRP levels (ng/ml) only in the AT+RT group after 6 months of interdisciplinary intervention compared with baseline condition. Conversely, α-MSH levels (ng/ml) increased only in the AT group after 12 months of interdisciplinary intervention compared with baseline condition.
  
  
  CONCLUSIONS
  Aerobic training (AT) as part of an interdisciplinary therapy is more effective than aerobic plus resistance training (AT+RT) to improve secretion of anorexigenic/orexigenic factors in obese adolescents.
authors.affiliation: Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo - UNIFESP, Brazil. junecarnier@gmail.com
authors.forename: June
authors.initials: J
authors.lastname: Carnier
authors.forename: Marco Túlio
authors.initials: MT
authors.lastname: de Mello
authors.forename: Carolina
authors.initials: C
authors.lastname: Ackel-DElia
authors.forename: Flavia Campos
authors.initials: FC
authors.lastname: Corgosinho
authors.forename: Raquel Munhoz da Silveira
authors.initials: RM
authors.lastname: Campos
authors.forename: Priscila de Lima
authors.initials: Pde L
authors.lastname: Sanches
authors.forename: Deborah Cristina Landi
authors.initials: DC
authors.lastname: Masquio
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Bueno
authors.forename: Aline de Piano
authors.initials: Ade P
authors.lastname: Ganen
authors.forename: Aniela C
authors.initials: AC
authors.lastname: Martins
authors.forename: Danielle Arisa
authors.initials: DA
authors.lastname: Caranti
authors.forename: Lian
authors.initials: L
authors.lastname: Tock
authors.forename: Ana Paula Grotti
authors.initials: AP
authors.lastname: Clemente
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Ana R
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D000293:Adolescent; D054369:Agouti-Related Protein / Q000097:blood; D001823:Body Composition; D015992:Body Mass Index; D004435:Eating; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007028:Hypothalamic Hormones / Q000097:blood; D008297:Male; D008543:Melanins / Q000097:blood; D009478:Neuropeptide Y / Q000097:blood; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*; D010907:Pituitary Hormones / Q000097:blood; D055070:Resistance Training; D012527:Satiation; D015431:Weight Loss; D055815:Young Adult; D000521:alpha-MSH / Q000097:blood
chemical_list: C515198:AGRP protein, human; D054369:Agouti-Related Protein; D007028:Hypothalamic Hormones; D008543:Melanins; D009478:Neuropeptide Y; D010907:Pituitary Hormones; D000521:alpha-MSH; C019463:melanin-concentrating hormone
keywords: Aerobic training; Neuropeptides; Obesity; Resistance training