title: Aerobic glycolysis: a novel target in kidney cancer.
abstract: Renal cell carcinoma (RCC) is a heterogenous group of cancers that arise from the nephron. While there are distinct histologic subtypes associated with common genetic alterations, most forms of RCC are linked by a common pathway of dysregulated metabolism. Reliance on aerobic glycolysis, a feature of cancer first hypothesized by Warburg, is a common feature in sporadic and hereditary forms of kidney cancer. Two hereditary forms of RCC, succinate dehydrogenase (SDH) and hereditary leiomyomatosis and RCC (HLRCC), are characterized by mutations in Krebs cycle enzymes, rendering them dependent on glycolysis for energy requirements. The reliance on these pathways may make them vulnerable to novel metabolic strategies, including inhibition of glycolysis, glucose uptake and macromolecule biosynthesis.
authors.affiliation: Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Shuch
authors.forename: W Marston
authors.initials: WM
authors.lastname: Linehan
authors.forename: Ramaprasad
authors.initials: R
authors.lastname: Srinivasan
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D002952:Citric Acid Cycle / Q000235:genetics; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000235:genetics; D006593:Hexokinase / Q000378:metabolism; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D018231:Leiomyomatosis / Q000235:genetics / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods*; D011770:Pyruvate Kinase / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000235:genetics / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D013385:Succinate Dehydrogenase; D006593:Hexokinase; D011770:Pyruvate Kinase; D005947:Glucose