title: Association of genital human papillomavirus infection with HIV acquisition: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To conduct a systematic review and a meta-analysis of epidemiological studies investigating the association of genital human papillomavirus (HPV) infection and HIV acquisition.
  
  
  METHODS
  Systematic review and meta-analysis.
  
  
  METHODS
  Scientific databases and conference abstracts were systematically searched to identify all relevant studies published up to 31 January 2012. Search terms included ‘HIV’, ‘HPV’, ‘humanpapillomavirus’ and ‘papillomaviridae’ as keywords or text, in the title or abstract.
  
  
  METHODS
  To be eligible for inclusion, a study had to be conducted among humans, report data on HIV incidence, and assess genital HPV infection. Summary ORs and 95% CIs were estimated from the extracted data using random-effect meta-analysis. Subgroup analyses were conducted for high-risk (HR) and low-risk(LR) HPV oncogenic risk groups. Between-study heterogeneity and publication bias were assessed.
  
  
  RESULTS
  Of 2601 identified abstracts, six observational studies, comprising 6567 participants were retained for the systematic review and the meta-analysis. HIV acquisition was significantly associated with HPV infection (summary OR=1.96; 95% CI 1.55 to 2.49). HIV incident infection was significantly associated with HR-HPV in five of six studies and with LR-HPV in two out of five. The association was significant for HR-HPV(summary OR=1.92; 95% CI 1.49 to 2.46) and borderline for LR-HPV. No between-study heterogeneity was detected. There was a borderline indication of publication bias.
  
  
  CONCLUSIONS
  Further research is needed to elucidate the biological mechanisms involved, and assess the effect of HPV vaccination on HIV acquisition, using vaccines with broad coverage of HPV genotypes. Such research could have important public health implications for HIV prevention.
authors.affiliation: CESP INSERM-UVSQ UMRS-1018, Villejuif, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Lissouba
authors.forename: Philippe
authors.initials: P
authors.lastname: Van de Perre
authors.forename: Bertran
authors.initials: B
authors.lastname: Auvert
mesh_terms: D005260:Female; D005602:France / Q000453:epidemiology; D005838:Genotype; D006679:HIV Seropositivity / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D015994:Incidence; D008297:Male; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D012749:Sexually Transmitted Diseases / Q000150:complications* / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D013601:T-Lymphocytes / Q000276:immunology*; D014779:Virus Replication