title: Enantioselective C-H arylation strategy for functionalized dibenzazepinones with quaternary stereocenters.
abstract: Tada! Highly functionalized chiral dibenzazepinones are obtained by a mild palladium(0)-catalyzed enantioselective C-H arylation with excellent selectivities by using simple taddol phosphoramidite ligands. The amide tether allows exclusive regioselectivity through a rare eight-membered palladacycle intermediate.
authors.affiliation: Laboratory of Asymmetric Catalysis and Synthesis, EPFL SB ISIC LCSA, BCH 4305, 1015 Lausanne, Switzerland.
authors.forename: Tanguy
authors.initials: T
authors.lastname: Saget
authors.forename: Nicolai
authors.initials: N
authors.lastname: Cramer
keywords: CH activation; asymmetric catalysis; cooperative effects; heterocycle; palladium