title: In vitro and in vivo evaluation of orthopedic interface repair using a tissue scaffold with a continuous hard tissue-soft tissue transition.
abstract: Tendon tears produce pain and decrease joint stability; each year, over 1.1 million rotator cuff tendon surgical procedures are performed worldwide. However, surgical success is highly variable, and the inability of the procedure to drive the regeneration of the normal tendon-bone interface has been identified as a key factor in surgical failure. This study focuses on the development, in vitro evaluation, and in vivo assessment of a tissue scaffold derived from bovine cancellous bone with the potential to direct regeneration of a bone-soft tissue interface. The scaffold is a highly porous scaffold with a continuous hard tissue-soft tissue transition that facilitates load transfer across the interface and contains all of the extracellular matrix components of the orthopedic interface. This study demonstrated the in vitro characterization of the mechanical properties and successful in vivo assessment using an ovine model.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Darryl A
authors.initials: DA
authors.lastname: Dickerson
authors.forename: Tarik N
authors.initials: TN
authors.lastname: Misk
authors.forename: David C
authors.initials: DC
authors.lastname: Van Sickle
authors.forename: Gert J
authors.initials: GJ
authors.lastname: Breur
authors.forename: Eric A
authors.initials: EA
authors.lastname: Nauman
mesh_terms: D000818:Animals; D018775:Bone Demineralization Technique / Q000379:methods; D001842:Bone and Bones / Q000648:ultrastructure; D002417:Cattle; D002448:Cell Adhesion / Q000502:physiology; D049109:Cell Proliferation; D002478:Cells, Cultured; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008422:Materials Testing / Q000379:methods; D008855:Microscopy, Electron, Scanning; D012038:Regeneration / Q000502:physiology; D017006:Rotator Cuff / Q000502:physiology; D000070636:Rotator Cuff Injuries; D034561:Sheep, Domestic; D013314:Stress, Mechanical; D013708:Tendon Injuries / Q000473:pathology / Q000601:surgery*; D054457:Tissue Scaffolds; D016474:Weight-Bearing / Q000502:physiology