title: Lateral pharyngotomy for selected invasive squamous cell carcinoma of the lateral oropharynx. Part II: when and why.
abstract: OBJECTIVE
  To analyze local failure following lateral pharyngotomy for selected untreated invasive squamous cell carcinoma (SCC) of the lateral oropharynx.
  
  
  METHODS
  Retrospective review from a university teaching hospital.
  
  
  METHODS
  Inception cohort of 91 patients who underwent lateral pharyngotomy for an isolated and previously untreated selected invasive carcinoma of the lateral oropharynx classified as T1 (26), T2 (47), T3 (11), and T4 (7). Induction chemotherapy, neck dissection, and postoperative radiation therapy were used in 91.2%, 94.5%, and 53.5% of patients.
  
  
  RESULTS
  The 5-year Kaplan-Meier estimate of local failure was 16.6% for T1, 19% for T2, 38.6% for T3, and 16.7% for T4 lesions (P = .46). In a logistic regression model, only positive margins of resection statistically increased (P = .01) the risk for local failure. In patients with safe margins of resection, the 5-year Kaplan-Meier estimate of local failure was 5.6% for T1 lesions, 10.7% for T2 lesions, 23.8% for T3 lesions, and 20% for T4 lesions (P = .4). Local failure had a significant impact on increased nodal failure (P = .001) and on reduced survival (P < .0001).
  
  
  CONCLUSIONS
  The lateral pharyngotomy approach should be viewed as a valuable oncologic alternative to both mandibulotomy and chemoradiation in patients with selected SCC of the lateral oropharynx.
authors.affiliation: Université Paris Descartes Sorbonne Paris Cité, HEGP, APHP, Service d'Oto-Rhino-Laryngologie et Chirurgie Cervico-Faciale, Paris.
authors.forename: Ollivier
authors.initials: O
authors.lastname: Laccourreye
authors.forename: José
authors.initials: J
authors.lastname: Benito
authors.forename: Dominique
authors.initials: D
authors.lastname: Garcia
authors.forename: Madeleine
authors.initials: M
authors.lastname: Menard
authors.forename: Pierre
authors.initials: P
authors.lastname: Bonfils
authors.forename: Christopher
authors.initials: C
authors.lastname: Holsinger
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009960:Oropharynx; D010610:Pharyngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D010611:Pharyngectomy / Q000379:methods*; D012189:Retrospective Studies; D017211:Treatment Failure
keywords: Cancer; oropharynx; pharyngotomy; surgery