title: Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi.
abstract: The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4  μ g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg(-1)·day(-1).
authors.affiliation: Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No. 130, Colonia Chuburná de Hidalgo, 97200 Mérida, YUC, Mexico.
authors.forename: Glendy
authors.initials: G
authors.lastname: Polanco-Hernández
authors.forename: Fabiola
authors.initials: F
authors.lastname: Escalante-Erosa
authors.forename: Karlina
authors.initials: K
authors.lastname: García-Sosa
authors.forename: María E
authors.initials: ME
authors.lastname: Rosado
authors.forename: Eugenia
authors.initials: E
authors.lastname: Guzmán-Marín
authors.forename: Karla Y
authors.initials: KY
authors.lastname: Acosta-Viana
authors.forename: Alberto
authors.initials: A
authors.lastname: Giménez-Turba
authors.forename: Efraín
authors.initials: E
authors.lastname: Salamanca
authors.forename: Luis M
authors.initials: LM
authors.lastname: Peña-Rodríguez