title: Electromechanical relationship in hypertrophic cardiomyopathy.
abstract: We examined whether there is a relationship between repolarization abnormalities on electrocardiography (EKG) and deformation abnormalities by echocardiography. Analysis of baseline EKGs and mechanical (echo-based deformation) changes was performed in 128 patients with a clinical diagnosis of hypertrophic cardiomyopathy (HCM). Patients with left ventricular hypertrophy (LVH) or repolarization abnormalities had higher septal thickness when compared to patients with normal EKG. Patients with EKG evidence of LVH or QTc prolongation had lower systolic velocity, systolic strain, systolic strain rate, late diastolic velocity, and late diastolic strain rate than patients with a normal EKG. Patients with strain pattern or ST depression/T-wave inversion had lower systolic velocity, systolic strain, systolic strain rate, early diastolic velocity, and late diastolic velocity when compared to patients with normal EKGs. LVH and repolarization abnormalities on surface EKG are markers of impaired systolic and diastolic mechanics in HCM.
authors.affiliation: Division of Cardiology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 871, Baltimore, MD 21201, USA.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Lin
authors.forename: Hsin-Yueh
authors.initials: HY
authors.lastname: Liang
authors.forename: Aurelio
authors.initials: A
authors.lastname: Pinheiro
authors.forename: Veronica
authors.initials: V
authors.lastname: Dimaano
authors.forename: Lars
authors.initials: L
authors.lastname: Sorensen
authors.forename: Miguel
authors.initials: M
authors.lastname: Aon
authors.forename: Larisa G
authors.initials: LG
authors.lastname: Tereshchenko
authors.forename: Yihan
authors.initials: Y
authors.lastname: Chen
authors.forename: Meixiang
authors.initials: M
authors.lastname: Xiang
authors.forename: Theodore P
authors.initials: TP
authors.lastname: Abraham
authors.forename: M Roselle
authors.initials: MR
authors.lastname: Abraham
mesh_terms: D000200:Action Potentials; D000328:Adult; D000368:Aged; D001696:Biomechanical Phenomena; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016009:Chi-Square Distribution; D003971:Diastole; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012042:Registries; D013599:Systole; D013997:Time Factors; D016277:Ventricular Function, Left