title: Microwave ablation with or without resection for colorectal liver metastases.
abstract: BACKGROUND
  Ablation with or without resection for colorectal liver metastases has been suggested as a potential method of improving survival if complete surgical resection is not possible. This study assessed the safety and efficacy of surgical microwave ablation (MWA) with or without resection for colorectal liver metastases.
  
  
  METHODS
  A retrospective case series was reviewed. Data was extracted for all patients treated with open MWA with or without resection for colorectal liver metastases. Endpoints included postoperative 30-day morbidity and mortality, local treatment failure, disease free survival and overall survival.
  
  
  RESULTS
  A total of 43 patients with technically irresectable disease were treated with MWA; 28 underwent combined MWA and resection, whilst 15 underwent MWA as the sole treatment modality. Overall post-operative morbidity was 35%, 30-day postoperative mortality 2%. At a median follow-up of 15 months, local treatment failure was observed in 4% of ablated lesions. 3-year OS was 36% for MWA group, compared to 45% for the combined ablate/resect group with 3-year DFS of 32% and 8% respectively.
  
  
  CONCLUSIONS
  Microwave ablation with or without resection is a safe and effective method of achieving local disease control. Ablation with or without resection is associated with good long-term outcomes, and may be a suitable treatment option for small non-resectable colorectal liver metastases.
authors.affiliation: Department of General and Hepatobiliary Surgery, University Hospital Aintree, Longmoor Lane, Liverpool L69 3GA, United Kingdom. s.staettner@salk.at
authors.forename: S
authors.initials: S
authors.lastname: Stättner
authors.forename: R P
authors.initials: RP
authors.lastname: Jones
authors.forename: V S
authors.initials: VS
authors.lastname: Yip
authors.forename: K
authors.initials: K
authors.lastname: Buchanan
authors.forename: G J
authors.initials: GJ
authors.lastname: Poston
authors.forename: H Z
authors.initials: HZ
authors.lastname: Malik
authors.forename: S W
authors.initials: SW
authors.lastname: Fenwick
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017115:Catheter Ablation / Q000379:methods*; D015331:Cohort Studies; D003082:Colectomy / Q000379:methods / Q000401:mortality; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods / Q000401:mortality; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008872:Microwaves / Q000627:therapeutic use; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods / Q000401:mortality; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D006113:United Kingdom
keywords: Ablation; Colorectal; Liver; Microwave