title: Osteosarcoma: evolution of treatment paradigms.
abstract: This paper reviews the contribution of chemotherapy in the conquest of osteosarcoma. It discusses how the treatment of osteosarcoma has evolved over the last five decades, resulting in a more than fivefold increase in survival. Though the initial improvements in survival were dramatic, essentially there has been no change in the outlook for this disease over the past 30 years. The paper also highlights the necessity of a multidisciplinary approach to combat this disease and stresses the need to explore newer treatment agents in order to build on the lessons learnt from the past while striving to achieve greater levels of success.
authors.affiliation: Children's Cancer Hospital, University of Texas M.D Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Norman
authors.initials: N
authors.lastname: Jaffe
authors.forename: Ajay
authors.initials: A
authors.lastname: Puri
authors.forename: Hans
authors.initials: H
authors.lastname: Gelderblom