title: Genital ulcer development in patients with acute promyelocytic leukaemia treated with all-trans retinoic Acid: a case series.
abstract: We report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcers after being prescribed all-trans retinoic acid (ATRA) as a part of chemotherapy for APL. This is the first series of cases describing genital ulcers, as a unique and rare complication of ATRA used for treatment of APL in these patients, with no other cause identified. Following temporary cessation of ATRA for a few days in these three cases, improvement of the ulcers was noted.
authors.affiliation: Department of Hematology, Sultan Qaboos University Hospital, Al-Khoud, P.O.Box 35 Muscat 123, Sultanate of Oman.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al Huneini
authors.forename: Fauzia
authors.initials: F
authors.lastname: Wasim
authors.forename: Khalil
authors.initials: K
authors.lastname: Al Farsi
authors.forename: Murtadha
authors.initials: M
authors.lastname: Al-Khabori
authors.forename: Salam
authors.initials: S
authors.lastname: Al Kindi
keywords: ATRA; Acute promyelocytic leukaemia; All-trans retinoic acid; Fever; Scrotal ulcers