title: [Protective effect of cytoflavin and its components in mice with acute alloxan intoxication].
abstract: We have studied the protective effect of cytoflavin and its components (meglumine sodium succinate, riboflavin, inosine and nicotinamide) in mice with acute alloxan intoxication. It is established that cytoflavin and its components possessing in vitro antioxidant activity (riboflavin, inosine and nicotinamide) significantly decrease the hyperglycemic effect of alloxan. The protective effect of cytoflavin in animals with behavioral disorders caused by acute alloxan intoxication is related to the effect of meglumine sodium succinate and inosine, but does not depend on the influence of these substances on free-radical oxidation processes.
authors.forename: I A
authors.initials: IA
authors.lastname: Volchegorskiĭ
authors.forename: L M
authors.initials: LM
authors.lastname: Rassokhina
authors.forename: S G
authors.initials: SG
authors.lastname: Ermakova
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Miroshnichenko
mesh_terms: D000208:Acute Disease; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control*; D004338:Drug Combinations; D005260:Female; D005486:Flavin Mononucleotide / Q000494:pharmacology*; D006943:Hyperglycemia / Q000139:chemically induced / Q000517:prevention & control*; D007290:Inosine Diphosphate / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009536:Niacinamide / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate