title: Fusions between dendritic cells and whole tumor cells as anticancer vaccines.
abstract: Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecules and in the context of co-stimulatory signals. DC-cancer cell fusions have been shown to stimulate potent antitumor immune responses in animal models. In early clinical trials, however, the antitumor effects of DC-cancer cell fusions are not as vigorous as in preclinical settings. This mini-review summarizes recent advances in anticancer vaccines based on DC-cancer cell fusions.
authors.affiliation: Division of Gastroenterology and Hepatology; Department of Internal Medicine; The Jikei University School of Medicine; Tokyo, Japan ; Institute of Clinical Medicine and Research; The Jikei University School of Medicine; Tokyo, Japan ; Department of Oncology, Institute of DNA Medicine; The Jikei University School of Medicine; Tokyo, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Koido
authors.forename: Sadamu
authors.initials: S
authors.lastname: Homma
authors.forename: Masato
authors.initials: M
authors.lastname: Okamoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Namiki
authors.forename: Kazuki
authors.initials: K
authors.lastname: Takakura
authors.forename: Kan
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Mikio
authors.initials: M
authors.lastname: Kajihara
authors.forename: Seiji
authors.initials: S
authors.lastname: Arihiro
authors.forename: Hiroo
authors.initials: H
authors.lastname: Imazu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Arakawa
authors.forename: Shin
authors.initials: S
authors.lastname: Kan
authors.forename: Hideo
authors.initials: H
authors.lastname: Komita
authors.forename: Masaki
authors.initials: M
authors.lastname: Ito
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ohkusa
authors.forename: Jianlin
authors.initials: J
authors.lastname: Gong
authors.forename: Hisao
authors.initials: H
authors.lastname: Tajiri
keywords: anticancer vaccines; cell fusions; dendritic cells