title: Treatment of stage I seminoma: 25 years of experience.
abstract: OBJECTIVE
  To review management and outcomes in patients with stage I seminoma after orchidectomy.
  
  
  METHODS
  Between 1979 and 2004 a total 292 patients with stage I seminoma were treated with adjuvant chemotherapy or radiotherapy or were placed on surveillance. Median age at diagnosis was 36 years (range 20-69), with median follow-up 76.5 months (range 11-294). Of the patients, 200 (68.5%) were treated with adjuvant chemotherapy, 72 (24.6%) were irradiated and 20 (6.8%) were placed on surveillance.
  
  
  RESULTS
  The probability of 5-year overall survival and relapse-free survival for the entire group was 100% and 95.1% respectively. The 5-year relapse-free survival for adjuvant chemotherapy was 97.2%, for radiotherapy 94.6%, and 31.4% for the surveillance group. Of 24 (8.4%) patients who had relapse in lymph nodes and/or internal organs, 14/20 patients were in the surveillance group. All patients who had a relapse were salvaged successfully with chemotherapy. The toxicity of chemotherapy and radiotherapy was acceptable. No severe reactions were observed.
  
  
  CONCLUSIONS
  Our results confirm the excellent prognosis for patients with stage I seminoma after orchidectomy treated with adjuvant chemotherapy or radiotherapy. The high rate of relapse in our surveillance group suggests the necessity of adjuvant treatment.
authors.affiliation: Urooncology Department, Maria Skłodowska-Curie, Memorial Cancer Hospital, Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pilichowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Pęczkowski
authors.forename: Dorota
authors.initials: D
authors.lastname: Rosińska-Okrasa
authors.forename: Barbara
authors.initials: B
authors.lastname: Trzaska
authors.forename: Anna
authors.initials: A
authors.lastname: Skowrońska-Gardas
authors.forename: Tomasz
authors.initials: T
authors.lastname: Demkow
keywords: chemotherapy; radiotherapy; seminoma stage I; surveillance