title: The clinical importance of fungal biofilms.
abstract: Fungal biofilms have become an increasingly important clinical problem. The widespread use of antibiotics, frequent use of indwelling medical devices, and a trend toward increased patient immunosuppression have resulted in a creation of opportunity for clinically important yeasts and molds to form biofilms. This review will discuss the diversity and importance of fungal biofilms in the context of clinical medicine, provide novel insights into the clinical management of fungal biofilm infection, present evidence why these structures are recalcitrant to antifungal therapy, and discuss how our knowledge and understanding may lead to novel therapeutic intervention.
authors.affiliation: Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. Electronic address: gordon.ramage@glasgow.ac.uk.
authors.forename: Gordon
authors.initials: G
authors.lastname: Ramage
authors.forename: Craig
authors.initials: C
authors.lastname: Williams
mesh_terms: D018441:Biofilms; D025141:Drug Resistance, Fungal; D005658:Fungi; D006801:Humans; D009181:Mycoses