title: Stereoselective total synthesis of ieodomycins A and B and revision of the NMR spectroscopic data of ieodomycin B.
abstract: Stereoselective total synthesis of antimicrobial marine metabolites ieodomycin A and B have been accomplished starting from commercially available 4-pentyn-1-ol featuring strategic application of the Negishi reaction, Kumada coupling, and Crimmins acetate aldol. This revises the proton NMR spectra of ieodomycin B.
authors.affiliation: Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.
authors.forename: Sayantan
authors.initials: S
authors.lastname: Das
authors.forename: Rajib Kumar
authors.initials: RK
authors.lastname: Goswami
mesh_terms: D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C584454:4-hydroxy-6-(3-methylhexa-3,5-dienyl)tetrahydropyran-2-one; D005231:Fatty Acids, Unsaturated; C561379:Ieodomycin A; D007783:Lactones; D011753:Pyrones