title: Polymorphisms in TREX1 and susceptibility to HIV-1 infection.
abstract: TREX-1 is a restriction factor against HIV-1. The coding sequence of TREX1 gene was analysed in HIV+ subjects searching for genetic variations possibly associated with the susceptibility to HIV infection. The single nucleotide polymorphism rs3135945 was significantly associated with HIV infection, emphasizing the involvement of TREX-1 in the anti-HIV response.
authors.affiliation: Department of Immunology, Institute of Biologic Sciences, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Pontillo
authors.forename: M
authors.initials: M
authors.lastname: Girardelli
authors.forename: E
authors.initials: E
authors.lastname: Catamo
authors.forename: A J
authors.initials: AJ
authors.lastname: Duarte
authors.forename: S
authors.initials: S
authors.lastname: Crovella
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D005090:Exodeoxyribonucleases / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000821:virology; D015497:HIV-1; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D010750:Phosphoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D010750:Phosphoproteins; D005090:Exodeoxyribonucleases; C429526:three prime repair exonuclease 1