title: Cerebral Sinus Venous Thrombosis due to Asparaginase Therapy.
abstract: We report a 9-year-old boy with acute lymphoblastic leukemia (ALL) in high-risk group who suffered from left sided focal seizures and ipsilateral hemiparesis during his induction with Asparaginase chemotherapy. Superior sagittal sinus thrombosis and right frontal hemorrhage were demonstrated on brain magnetic resonance imaging (MRI) scans . Anticoagulation was initiated with unfractionated heparin and switched to low molecular weight heparin after 3 weeks and continued for 6 months. At one-year followup, he had complete response to chemotherapy for ALL, with residual mild left hemiparesis, and his MRI scans revealed recanalized venous sinuses. The case highlights the importance of considering cerebral venous thrombosis as a complication of Asparaginase therapy.
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, P.O. Box 40047, MBC J-76, Jeddah 21499, Saudi Arabia.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Alsaid
authors.forename: Shamshad
authors.initials: S
authors.lastname: Gulab
authors.forename: Mohammed
authors.initials: M
authors.lastname: Bayoumi
authors.forename: Saleh
authors.initials: S
authors.lastname: Baeesa