title: Impairment of vascular endothelial function following reperfusion therapy in patients with acute myocardial infarction.
abstract: OBJECTIVE
  To investigate vascular endothelial impairment as a result of reperfusion therapy in patients with acute myocardial infarction (AMI).
  
  
  METHODS
  Patients with AMI underwent reperfusion therapy (percutaneous cardiac intervention [PCI] or thrombolytic therapy) or conservative drug therapy. Healthy control subjects were recruited. Endothelial impairment was assessed via endothelial nitric oxide (NO) synthase (eNOS), NO and endothelin-1 (ET-1) levels, 24 h after reperfusion or on enrolment, as appropriate.
  
  
  RESULTS
  Patients who underwent PCI (n = 47) or thrombolytic therapy (n = 45) had significantly lower eNOS and NO levels, and higher ET-1 levels than those who received conservative drug therapy (n = 46). All patient groups had significantly lower eNOS and NO levels, and higher ET-1 levels, than controls (n = 45). There was a significant positive correlation between eNOS and NO, as well as significant negative correlations between eNOS/ET-1 and NO/ET-1 in all four groups.
  
  
  CONCLUSIONS
  Patients with AMI who underwent reperfusion therapy displayed low eNOS activity. This may result in impairment of endothelial function via downregulation of NO and upregulation of ET-1.
authors.affiliation: Cadre Ward, First Hospital, Jilin University, Changchun, China.
authors.forename: Zhaoying
authors.initials: Z
authors.lastname: Yang
authors.forename: Jinliang
authors.initials: J
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Kong
authors.forename: Suisheng
authors.initials: S
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood / Q000235:genetics; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D009569:Nitric Oxide / Q000097:blood; D052250:Nitric Oxide Synthase Type III / Q000097:blood / Q000235:genetics; D062645:Percutaneous Coronary Intervention / Q000379:methods*
chemical_list: D019332:Endothelin-1; D005343:Fibrinolytic Agents; D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
keywords: Acute myocardial infarction; endothelial nitric oxide synthase (eNOS); endothelin-1; nitric oxide; reperfusion therapy