title: [Progress in neuropathology changes the understanding of neurodegenerative diseases].
abstract: Improvement of the analytical methods and routine use of immunohistochemistry have demonstrated that most neurodegenerative diseases, known to-day, are characterized by the accumulation of one or several specific proteins for example Abeta peptide and Tau protein in Alzheimer disease, alpha-synuclein in Parkinson disease and dementia with Lewy bodies, TDP-43 in a large group of fronto-temporal dementia. In the case of Alzheimer and Lewy body disease, recent data suggest that misfolding of Abeta peptide, of Tau protein or of alpha-synuclein may propagate to the normal protein of the host in a way that reminds the propagation observed in prion diseases.
authors.affiliation: Laboratoire de neuropathologie Raymond-Escourolle, groupe hospitalier Pitié-Salpêtrière, AP-HP, 75013 Paris, France. charles.duyckaerts@psl.aphp.fr
authors.forename: Charles
authors.initials: C
authors.lastname: Duyckaerts
authors.forename: Danielle
authors.initials: D
authors.lastname: Seilhean
mesh_terms: D016229:Amyloid beta-Peptides / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D000818:Animals; D032882:Comprehension; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D019636:Neurodegenerative Diseases / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009462:Neurology / Q000379:methods / Q000639:trends*; D051381:Rats; D016875:tau Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins