title: MRI pre-treatment tumour volume in maxillary complex squamous cell carcinoma treated with surgical resection.
abstract: Tumour volume (Tv) measurements obtained from pre-treatment CT and MRI have increasingly shown to be more reliable predictors of outcome than TNM stage. The aim of this study was to determine the correlation of MRI calculated maxillary complex tumour volume with patient outcome.
  
  
  METHODS
  The medical records of 39 patients with squamous cell carcinoma involving the maxillary sinus, maxilla, hard palate and maxillary alveolus were reviewed and tumour volume measurements completed on pre-treatment MRI.
  
  
  RESULTS
  The mean tumour volume was 12.79 ± 24.31 cm(3). Independent samples t test was significant for increasing overall all-cause survival and decreasing tumour volume (1 year: p = 0.003; 5-year: p = 0.031). Cox regression was significant for stratified tumour volume, nodal involvement and peri-neural invasion for predicting disease-free survival.
  
  
  CONCLUSIONS
  MRI measured tumour volume assessment appears to be a reliable predictor of survival in patients with maxillary complex SCC treated by surgical resection.
authors.affiliation: Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: Karen.a.eley@gmail.com.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Eley
authors.affiliation: Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: Steve.watt-smith@ndm.ox.ac.uk.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Watt-Smith
authors.affiliation: Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: Paul.william.boland@gmail.com.
authors.forename: Paul
authors.initials: P
authors.lastname: Boland
authors.affiliation: Department of Plastic Surgery, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: mattpotters@hotmail.com.
authors.forename: Matthew
authors.initials: M
authors.lastname: Potter
authors.affiliation: Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: Stephen.golding@nds.ox.ac.uk.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Golding
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002423:Cause of Death; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008441:Maxillary Neoplasms / Q000473:pathology* / Q000601:surgery; D008444:Maxillary Sinus Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D037981:Neck Dissection; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D010157:Palatal Neoplasms / Q000473:pathology* / Q000601:surgery; D011300:Preoperative Care; D019651:Plastic Surgery Procedures / Q000379:methods; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: Mouth neoplasms; Oral cancer; Tumour volume