title: Efficacy of tigecycline for the treatment of complicated intra-abdominal infections in real-life clinical practice from five European observational studies.
abstract: OBJECTIVE
  Tigecycline is a broad-spectrum antibiotic approved for the treatment of complicated intra-abdominal infections (cIAIs). The efficacy of tigecycline when administered as monotherapy or in combination with other antibacterials in the treatment of cIAIs in routine clinical practice is described.
  
  
  METHODS
  Individual patient-level data were pooled from five European observational studies (July 2006 to October 2011).
  
  
  RESULTS
  A total of 785 cIAI patients who received tigecycline were included (mean age 63.1 ± 14.0 years). Of these, 56.6% were in intensive care units, 65.6% acquired their infection in hospital, 88.1% had at least one comorbidity and 65.7% had secondary peritonitis. The mean Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores at the beginning of treatment were 16.9 ± 7.6 (n = 614) and 7.0 ± 4.2 (n = 108), respectively, indicating high disease severity. Escherichia coli (41.8%), Enterococcus faecium (40.1%) and Enterococcus faecalis (21.1%) were the most frequently isolated pathogens; 49.1% of infections were polymicrobial and 17.5% were due to resistant pathogens. Overall, 54.8% (n = 430) received tigecycline as monotherapy and 45.2% (n = 355) as combination therapy for a mean duration of 10.6 days. Clinical response rates at the end of treatment were 77.4% for all patients (567/733), 80.6% for patients who received tigecycline as monotherapy (329/408), 75.2% for patients with a nosocomial infection (354/471), 75.8% for patients with an APACHE II score >15 (250/330) and 54.2% (32/59) for patients with a SOFA score ≥ 7.
  
  
  CONCLUSIONS
  In these real-life studies, tigecycline, alone and in combination, achieved favourable clinical response rates in patients with cIAI with a high severity of illness.
authors.affiliation: Klinikum Peine, Department of General, Visceral and Thoracic Surgery, Peine, Germany. christian.eckmann@klinikum-peine.de
authors.forename: Christian
authors.initials: C
authors.lastname: Eckmann
authors.forename: Philippe
authors.initials: P
authors.lastname: Montravers
authors.forename: Matteo
authors.initials: M
authors.lastname: Bassetti
authors.forename: Klaus Friedrich
authors.initials: KF
authors.lastname: Bodmann
authors.forename: Wolfgang R
authors.initials: WR
authors.lastname: Heizmann
authors.forename: Miguel
authors.initials: M
authors.lastname: Sánchez García
authors.forename: Xavier
authors.initials: X
authors.lastname: Guirao
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Capparella
authors.forename: Damien
authors.initials: D
authors.lastname: Simoneau
authors.forename: Hervé
authors.initials: H
authors.lastname: Dupont
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000379:methods; D005060:Europe; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D059413:Intraabdominal Infections / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000078304:Tigecycline; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
keywords: broad-spectrum antibacterial therapy; generalized peritonitis; glycylcycline antibiotics; non-interventional studies