title: Bioinspired artificial single ion pump.
abstract: Bioinspired artificial functional nanochannels for intelligent molecular and ionic transport control at the nanoscale have wide potential applications in nanofluidics, energy conversion, and biosensors. Although various smart passive ion transport properties of ion channels have been artificially realized, it is still hugely challenging to achieve high level intelligent ion transport features in biological ion pumps. Here we show a unique bioinspired single ion pump based on a cooperative pH response double-gate nanochannel, whose gates could be opened and closed alternately/simultaneously under symmetric/asymmetric pH environments. With the stimulation of the double-gate nanochannel by continuous switching of the symmetric/asymmetric pH stimuli, the bioinspired system systematically realized three key ionic transport features of biological ion pumps, including an alternating gates ion pumping process under symmetric pH stimuli, transformation of the ion pump into an ion channel under asymmetric pH stimuli, and a fail-safe ion pumping feature under both symmetric and asymmetric pH stimuli. The ion pumping processes could well be reproduced under a concentration gradient. With the advantages of the extraordinary ionic transport functions of biological ion pumps, the bioinspired ion pump should find widespread applicability in active transportation-controlling smart nanofluidic devices, efficient energy conversions, and seawater desalinization, and open the way to design and develop novel bioinspired intelligent artificial nanochannel materials.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Huacheng
authors.initials: H
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Hou
authors.forename: Lu
authors.initials: L
authors.lastname: Zeng
authors.forename: Fu
authors.initials: F
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Dadong
authors.initials: D
authors.lastname: Yan
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
mesh_terms: D015374:Biosensing Techniques; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002384:Catalysis; D006863:Hydrogen-Ion Concentration; D016623:Ion Pumps / Q000737:chemistry*; D008567:Membranes, Artificial; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology; D043942:Nanotubes / Q000737:chemistry*; D011095:Polyethylenes; D058105:Polymerization; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D016623:Ion Pumps; D008567:Membranes, Artificial; D011095:Polyethylenes; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase