title: SLC classification: an update.
abstract: The 386 human SLC superfamily members are diverse in sequence, structure, and function. Using sequence similarity, we previously classified the SLC superfamily members and identified relationships among families. With the recent determination of new SLC structures and identification of previously unknown human SLC families, an update of our previous classification is timely. Here, we comprehensively compare the SLC sequences and structures and discuss the applicability of structure-based ligand discovery to key SLC members.
authors.affiliation: Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA. avner.schlessinger@mssm.edu
authors.forename: A
authors.initials: A
authors.lastname: Schlessinger
authors.forename: S W
authors.initials: SW
authors.lastname: Yee
authors.forename: A
authors.initials: A
authors.lastname: Sali
authors.forename: K M
authors.initials: KM
authors.lastname: Giacomini
mesh_terms: D000595:Amino Acid Sequence; D001692:Biological Transport; D019143:Evolution, Molecular; D006801:Humans; D008024:Ligands; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000145:classification*; D008962:Models, Theoretical; D016415:Sequence Alignment
chemical_list: D008024:Ligands; D026901:Membrane Transport Proteins