title: Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives.
abstract: Nowadays, there are increasing numbers of studies about synthetic chemicals according to the supply demands of bioactive chemicals. The current study aims to investigate genotoxic potential of bioactive synthetic pyridine compounds, phenyl-3-pyridinylmethanone (1), p-tolyl-3-pyridinylmethanone (2), and 4-methoxyphenyl-3-pyridinylmethanone (3), using Ames/Salmonella and Escherichia coli WP2 bacterial reversion mutagenicity test systems. The mutant bacterial tester strains sodium azide-sensitive Salmonella typhimurium TA1535, 9-aminoacridine-sensitive S. typhimurium TA1537, and N-methyl-N'-nitro-N-nitrosoguanidine-sensitive E. coli WP2uvrA were used to detect the mutagenic potential of the test compounds. The results indicated that none of the test substances showed significant mutagenic activity on S. typhimurium TA1535, TA1537, and E. coli WP2uvrA bacterial strains up to 1 µg/plate concentrations.
authors.affiliation: Department of Biology, Faculty of Art and Science, Erzincan University, Erzincan, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozkan
authors.affiliation: Erzurum Public Health Department, Erzurum, Turkey.
authors.forename: Demet Demirci
authors.initials: DD
authors.lastname: Gultekin
authors.affiliation: Department of Biology, Faculty Science, Ataturk University, Erzurum, Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Sezen
authors.affiliation: Department of Chemistry, Faculty of Art and Science, Coruh University, Artvin, Turkey.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Ozgeris
authors.affiliation: Department of Biology, Faculty Science, Ataturk University, Erzurum, Turkey.
authors.forename: Medine
authors.initials: M
authors.lastname: Gulluce
authors.affiliation: Department of Chemistry, Faculty of Art and Science, Sutcu Imam University, Kahramanmaras, Turkey ftumer@ksu.edu.tr.
authors.forename: Ferhan
authors.initials: F
authors.lastname: Tumer
mesh_terms: D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D007659:Ketones / Q000633:toxicity*; D050296:Microbial Viability / Q000187:drug effects; D016296:Mutagenesis / Q000187:drug effects*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009994:Osmolar Concentration; D011725:Pyridines / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D012997:Solvents / Q000633:toxicity*; D014421:Turkey
chemical_list: C000610661:4-methoxyphenyl-3-pyridinylmethanone; D007659:Ketones; D009153:Mutagens; D011725:Pyridines; D012997:Solvents; C000610660:p-tolyl-3-pyridinylmethanone; C000610659:phenyl-3-pyridinylmethanone
keywords: Ames/Salmonella; E. coli WP2; Mutagenicity; synthetic pyridine compounds