title: Fatal ischemic stroke complicating acute multifocal placoid pigment epitheliopathy: histopathological findings.
abstract: A previously healthy 29-year-old man was admitted to a tertiary referral center with acute left hemiparesis followed shortly by de novo convulsive status epilepticus. This was in the context of a 2-month history of flu-like symptoms, severe headaches, and retinopathy recently diagnosed as acute multifocal placoid pigment epitheliopathy. Neuroimaging demonstrated bilateral, multiple territory cerebral infarction. Despite intravenous methylprednisolone and craniotomy for the management of raised intracranial pressure, the patient deteriorated and died 14 days later. At autopsy, multiple infarcts of varying ages within a 10-day period were seen in association with a segmental giant cell vasculopathy of meningeal arteries.
authors.affiliation: Department of Neurosciences (BK-TT, JF), Alfred Health, Victoria, Australia; Vision Retinal Institute Eastern (DSC), Box Hill, Victoria, Australia; Departments of Ophthalmology (RH) and Anatomical Pathology (CM), Alfred Health, Victoria, Australia.
authors.forename: Benjamin K-T
authors.initials: BK
authors.lastname: Tsang
authors.forename: Devinder S
authors.initials: DS
authors.lastname: Chauhan
authors.forename: Rebecca
authors.initials: R
authors.lastname: Haward
authors.forename: Ida
authors.initials: I
authors.lastname: Whiteman
authors.forename: Judith
authors.initials: J
authors.lastname: Frayne
authors.forename: Catriona
authors.initials: C
authors.lastname: McLean
mesh_terms: D000208:Acute Disease; D000328:Adult; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology*; D002833:Choroiditis / Q000150:complications* / Q000175:diagnosis; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D000080364:Multifocal Choroiditis; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014057:Tomography, X-Ray Computed