title: Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I.
abstract: Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that is activated by 5'-triphosphate RNA molecules to induce type I interferon secretion and apoptosis in response to viral infection. We have designed a bifunctional small-interfering RNA that combines transforming growth factor β silencing with RIG-I activation to break tumor-induced immunosuppression. This strategy showed therapeutic efficacy in a murine model of pancreatic cancer.
authors.affiliation: Medizinische Klinik und Poliklinik IV; Klinikum der Universität München; Munich, Germany.
authors.forename: Max
authors.initials: M
authors.lastname: Schnurr
authors.forename: Peter
authors.initials: P
authors.lastname: Duewell
keywords: RIG-I; TGFβ; immunosuppression; pancreatic cancer; siRNA