title: Efficacy and safety of a new monophasic hyaluronic acid filler in the correction of nasolabial folds: a randomized, evaluator-blinded, split-face study.
abstract: BACKGROUND
  Hyaluronic acid (HA) fillers are frequently used for the correction of facial soft-tissue defects.
  
  
  OBJECTIVE
  To compare the efficacy and safety of a novel monophasic HA filler (mono-HA), and a well-studied biphasic HA filler (bi-HA), in the treatment of moderate to severe nasolabial folds.
  
  
  METHODS
  In this randomized, evaluator-blinded, split-face comparative study, subjects were randomized for injections with mono-HA or bi-HA on the left or right side of the face. Efficacy was determined by calculating the change in the Wrinkle Severity Rating Score (WSRS) relative to baseline. Local safety was assessed on the basis of subject diary entries which recorded erythema, swelling, induration, pruritus, irritation, mass, hematoma, pain, and dryness.
  
  
  RESULTS
  At week 24, the mean improvement in the WSRS from baseline was 2.18 ± 0.42 for the mono-HA side and 2.16 ± 0.41 for the bi-HA side. Both fillers were well-tolerated and adverse reactions were mild and transient in most cases.
  
  
  CONCLUSIONS
  Mono-HA has a non-inferior efficacy to bi-HA in the treatment of moderate to severe nasolabial folds.
authors.affiliation: Department of Dermatology, Asan Medical Center , Seoul , Korea.
authors.forename: Do Young
authors.initials: do Y
authors.lastname: Rhee
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Won
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Chang
authors.forename: Tai Kyung
authors.initials: TK
authors.lastname: Noh
authors.forename: Myoung Shin
authors.initials: MS
authors.lastname: Kim
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.forename: Gyeong Hun
authors.initials: GH
authors.lastname: Park
authors.forename: Jee Soo
authors.initials: JS
authors.lastname: An
authors.forename: Mi Woo
authors.initials: MW
authors.lastname: Lee
authors.forename: Jee Ho
authors.initials: JH
authors.lastname: Choi
authors.forename: Kee Chan
authors.initials: KC
authors.lastname: Moon
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Lim
mesh_terms: D000328:Adult; D000368:Aged; D003357:Cosmetic Techniques; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D007267:Injections; D008297:Male; D060052:Nasolabial Fold; D016037:Single-Blind Method; D015595:Skin Aging; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D006820:Hyaluronic Acid; C445361:Restylane