title: Evaluation of a heredofamilial cancer unit in increasing family history collection and genetic counseling referrals among Spanish oncologists at a university hospital.
abstract: A comprehensive family history is essential to identify patients at risk for hereditary cancer who could benefit from genetic counseling (GC). In a previous study, we observed a low occurrence of family history record (FHR) collection rate and GC referral among oncologists at our institution. The present work analyzes whether the implementation of a heredofamilial cancer unit (HFCU) would improve these parameters. We retrospectively compared the FHR rate in clinical records, National Cancer Institute (NCI) general criteria for hereditary cancer suspicion, GC referrals and FHR quality in two cohorts: cohort 1 (patients diagnosed before HFCU creation) and cohort 2 (after HFCU creation). Of 1,175 patients (590 cohort 1 and 585 cohort 2), FHRs were consigned in 27.3 % and 52.5 % of patients, respectively (p < 0.001). The GC referral of patients with any NCI criterion was 13.6 % xin cohort 1 vs. 40.5 % in cohort 2 (p < 0.001). FHR quality improved in terms of the total number of relatives (164 vs. 314, p = 0.1, N.S.) and number of healthy relatives consigned (80 vs. 191, p < 0.01). Nine mutations (6 BRCA, 1 MEN1, 2 Lynch), 4 unknown significance variants (all in BRCA) and 2 with no mutation were identified among patients referred from cohort 2. We conclude that the creation of a heredofamilial cancer unit has changed both FHR and GC referrals among oncologists at our institution, although continuous educational efforts are required.
authors.affiliation: Servicio de Oncología Médica; Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Calle Maiquez 7, 28007, Madrid, Spain, ivanpantic@hotmail.com.
authors.forename: Iván
authors.initials: I
authors.lastname: Márquez-Rodas
authors.forename: Sara
authors.initials: S
authors.lastname: López-Tarruella
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Jerez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Cavanagh
authors.forename: Sara
authors.initials: S
authors.lastname: Custodio
authors.forename: Daniel
authors.initials: D
authors.lastname: López-Trabada
authors.forename: Beatriz
authors.initials: B
authors.lastname: Moya
authors.forename: Sara
authors.initials: S
authors.lastname: Pérez
authors.forename: Ana B
authors.initials: AB
authors.lastname: Rupérez
authors.forename: Miguel
authors.initials: M
authors.lastname: Martín
mesh_terms: D002173:Cancer Care Facilities / Q000458:organization & administration*; D015331:Cohort Studies; D005817:Genetic Counseling; D006785:Hospitals, University / Q000458:organization & administration*; D006801:Humans; D008495:Medical Oncology; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D012017:Referral and Consultation; D013030:Spain