title: Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population.
abstract: OBJECTIVE
  To examine the association between the circadian locomotor output cycles kaput (CLOCK) gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease in Chinese people.
  
  
  METHODS
  This case-control study determined apolipoprotein E (APOE) and CLOCK rs1554483 G/C genotypes using polymerase chain reaction restriction fragment length polymorphism.
  
  
  RESULTS
  Unrelated patients with Alzheimer's disease (n = 130) and healthy controls (n = 188) were analysed for an association between the CLOCK gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease. In the whole sample and in APOE ε4 isoform noncarriers, the prevalence of CLOCK gene rs1554483 G allele carriers was significantly higher in patients with Alzheimer's disease than in controls. Among APOE ε4 carriers, the prevalence of CLOCK rs1554483 G allele carriers was not significantly different between patients with Alzheimer's disease and controls.
  
  
  CONCLUSIONS
  Among APOE ε4 noncarriers, but not APOE ε4 carriers, the CLOCK rs1554483 G allele was associated with increased susceptibility to Alzheimer's disease.
authors.affiliation: Department of Geriatrics, The West China Hospital of Sichuan University, Sichuan Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Chang-Quan
authors.initials: CQ
authors.lastname: Huang
authors.forename: Xiu-Ying
authors.initials: XY
authors.lastname: Hu
authors.forename: Song-Bing
authors.initials: SB
authors.lastname: Li
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D056926:CLOCK Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003710:Demography; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020033:Protein Isoforms / Q000235:genetics
chemical_list: D053327:Apolipoprotein E4; D020033:Protein Isoforms; D056926:CLOCK Proteins; C538943:CLOCK protein, human
keywords: APOE ε4 isoform; Alzheimer's disease; CLOCK gene rs1554483 G/C; apolipoprotein E (APOE); circadian locomotor output cycles kaput (CLOCK); polymorphism