title: Alloreactivity.
abstract: The alloimmune response between individuals genetically disparate for antigens encoded within the major histocompatibility complex (MHC) remains a substantial barrier to transplantation of solid organs, tissues, and hematopoietic stem cells. Alloreactivity has been an immunological paradox because of its apparent contradiction to the requirement of MHC restriction for the induction of normal T lymphocyte mediated immune responses. Through crystallographic analyses and experimental systems utilizing murine CD8(+) cytolytic T cell clones, major advances have been achieved in understanding the molecular and structural basis of T cell receptor recognition of MHC-peptide complexes and the basis of T cell mediated alloreactivity. These studies have further provided an explanation for the relatively high frequencies of alloreactive T cells compared to the frequencies of T cells for microbial derived antigens.
authors.affiliation: Department of Microbiology & Immunology, University of Melbourne, Parkville, VIC, Australia.
authors.forename: Sidonia B G
authors.initials: SB
authors.lastname: Eckle
authors.forename: Jamie
authors.initials: J
authors.lastname: Rossjohn
authors.forename: James
authors.initials: J
authors.lastname: McCluskey
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology; D006648:Histocompatibility / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology*; D051379:Mice; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D011487:Protein Conformation
chemical_list: D010455:Peptides