title: Pd-catalyzed regioselective allylation of mono- and disubstituted hydrazines.
abstract: Palladium-catalyzed allylation of hydrazines using allyl alcohols is reported. This highly efficient protocol furnishes monoallylated hydrazines selectively, in 27-99% yields. Following an optimization of the reaction conditions and of the Pd-ligands, the allylations of both mono- and disubstituted hydrazines were investigated, as well as the effects of C2-substitution on the allylating agent. Of particular interest, a novel method for the selective monoallylation of monosubstituted hydrazines is demonstrated.
authors.affiliation: Dept of Chemistry, Tartu University, Ravila 14a, Tartu, 50411, Estonia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Tšupova
authors.forename: Uno
authors.initials: U
authors.lastname: Mäeorg
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D006834:Hydrazines; D008024:Ligands; D020005:Propanols; C006463:allyl alcohol; D010165:Palladium