title: Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population.
abstract: OBJECTIVE
  To assess associations of the serum level of 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population.
  
  
  METHODS
  This cross-sectional study included 1382 female participants free of type 2 diabetes who were recruited in Shanghai. Blood samples were collected within a winter season and the serum levels of 25-hydroxyvitamin D, fasting plasma glucose and insulin, and other biochemical parameters were determined. Insulin resistance and β-cell function were assessed using the homeostasis model assessments of insulin resistance (HOMA-IR) and β-cell function (HOMA-B), respectively.
  
  
  RESULTS
  Multiple linear regression analyses adjusted for age, parathyroid hormone, Ca(2+) and BMI revealed that independent inverse associations existed between the serum level of 25-hydroxyvitamin D and HOMA-IR (P<0.001) and between the serum level of 25-hydroxyvitamin D and HOMA-B (P=0.001).
  
  
  CONCLUSIONS
  Serum vitamin D level is significantly and independently associated with insulin resistance and β-cell function in a healthy Chinese female population.
authors.affiliation: Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Min-fang
authors.initials: MF
authors.lastname: Tao
authors.forename: Zeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yao-hua
authors.initials: YH
authors.lastname: Ke
authors.forename: Jin-wei
authors.initials: JW
authors.lastname: He
authors.forename: Wen-zhen
authors.initials: WZ
authors.lastname: Fu
authors.forename: Chang-qing
authors.initials: CQ
authors.lastname: Zhang
authors.forename: Zhen-lin
authors.initials: ZL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology; D001402:B-Lymphocytes / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D002681:China / Q000208:ethnology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D