title: Study on the relationship between TagSNPs and haplotype of hCHK2 and esophageal cancer in Kazakh and Han in Xinjiang.
abstract: OBJECTIVE
  To determine the association of hCHK2 rs2278022, rs2602431, and rs2970077 polymorphisms and haplotypes with susceptibility to esophageal cancer in Kazakh and Han in Xinjiang Uygur Autonomous Region.
  
  
  METHODS
  Molecular epidemiology was carried out on 239 cases of esophageal cancer (132 Kazakh, 107 Han) and 513 controls (309 Kazakh, 204 Han) of Xinjiang. Polymorphisms of hCHK2 at rs2278022, rs2602431 and rs2970077 were analyzed by polymerase chain reaction-ligase detection reaction (PCR-LDR). Haplotypes were estimated by the SHEsis software. Statistical differences in genotype/haplotype frequencies, and frequencies between the case group and the control group were estimated.
  
  
  RESULTS
  1) No significant difference was observed in the frequency of hCHK2 at rs2278022, rs2602431 and rs2970077 between the cases and controls in Kazakh and Han (P > 0.05); 2) In Kazakh and Han, the distribution of haplotypes was not significantly different between esophageal cancer cases and controls (P > 0.05).
  
  
  CONCLUSIONS
  Polymorphisms of hCHK2 at rs2278022, rs2602431 and rs2970077 and haplotypes are unlikely to be associated with the susceptibility to esophageal cancer in Kazakh and Han.
authors.affiliation: Department of Stomach and Intestinal Surgery, the Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Yin
authors.forename: Hui-Xia
authors.initials: HX
authors.lastname: Zhang
authors.forename: Yan-Chao
authors.initials: YC
authors.lastname: Deng
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Ma
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
keywords: Kazakh nationality; esophageal cancer; hCHK2 gene; haplotype; single nucleotide polymorphism