title: Simulating psychophysical tuning curves in listeners with dead regions.
abstract: OBJECTIVE
  This study investigates the relation between diagnosis of dead regions based on the off-frequency psychophysical tuning curve (PTC) tip and the frequency and level of the probe tone.
  
  
  METHODS
  A previously developed functional model of auditory processing was used to simulate the complete loss of inner hair cells (IHC), dysfunction of outer hair cells (OHC), complete loss of IHCs in combination with OHC dysfunction, and IHC insensitivity. The model predictions were verified through comparison with experimental data.
  
  
  METHODS
  This study compares PTC data of five normal-hearing listeners and six hearing-impaired listeners with model-simulated PTC data.
  
  
  RESULTS
  It was shown that OHC activity and IHC insensitivity may significantly alter the shift of PTC tips with increasing probe level.
  
  
  CONCLUSIONS
  Model results suggest that OHC activity and IHC insensitivity can change the outcome of dead region diagnosis using PTCs. Supplementary to PTC dead region diagnostic information, model results may provide additional information regarding the edge frequency of a dead region and OHC function.
authors.affiliation: Department of Clinical and Experimental Audiology, The Academic Medical, Amsterdam, The Netherlands. b.warnaar@amc.nl
authors.forename: Bastiaan
authors.initials: B
authors.lastname: Warnaar
authors.forename: Morten L
authors.initials: ML
authors.lastname: Jepsen
authors.forename: Wouter A
authors.initials: WA
authors.lastname: Dreschler
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001301:Audiometry, Pure-Tone; D001306:Auditory Pathways / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D003051:Cochlea / Q000473:pathology / Q000503:physiopathology*; D003198:Computer Simulation; D005260:Female; D006199:Hair Cells, Auditory, Inner / Q000473:pathology; D018072:Hair Cells, Auditory, Outer / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008960:Models, Psychological; D019986:Persons with Hearing Disabilities / Q000523:psychology*; D010898:Pitch Perception; D011571:Psychoacoustics; D055815:Young Adult