title: The CTLA-4 and MCP-1 polymorphisms and susceptibility to systemic sclerosis: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and monocyte chemoattractant protein-1 (MCP-1) polymorphisms confer susceptibility to systemic sclerosis (SSc).
  
  
  METHODS
  MEDLINE and manual search were utilized to identify available articles. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, -1661 A/G, and -1722 C/T, and MCP-1 -2518 A/G polymorphisms, using a fixed-effect or random-effect model based on between-study heterogeneity.
  
  
  RESULTS
  Eleven comparative studies involving 959 SSc patients and 1739 controls were included in the meta-analysis. No association was found between SSc and the CTLA-4 +49 A/G polymorphism (OR for the +49 G allele = 1.032, 95% CI = 0.830-1.283, p = 0.779). However, an association between SSc and the CTLA-4 -318 TT + TC genotype (OR = 1.642, 95% CI = 1.034-2.609, p = 0.036). Meta-analyses failed to reveal an association between SSc and CTLA-4 -1722 C/T, MCP-1 -2518 A/G polymorphisms.
  
  
  CONCLUSIONS
  This meta-analysis of published data shows that the CTLA-4 -318 C/T polymorphism confers susceptibility to SSc.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul 136-705, Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D044466:Asian People / Q000235:genetics; D060908:CTLA-4 Antigen / Q000235:genetics*; D018932:Chemokine CCL2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D012595:Scleroderma, Systemic / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C111835:CCL2 protein, human; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D018932:Chemokine CCL2