title: BPC 157 and blood vessels.
abstract: This review focuses on the described effects of BPC 157 on blood vessels after different types of damage, and elucidate by investigating different aspects of vascular response to injury (endothelium damage, clotting, thrombosis, vasoconstriction, vasodilatation, vasculoneogenesis and edema formation) especially in connection to the healing processes. In this respect, BPC 157 was concluded to be the most potent angiomodulatory agent, acting through different vasoactive pathways and systems (e.g. NO, VEGF, FAK) and leading to optimization of the vascular response followed, as it has to be expected, by optimization of the healing process. Formation of new blood vessels involves two main, partly overlapping mechanisms, angiogenesis and vasculogenesis. The additional mechanism of arteriogenesis is involved in the formation of collaterals. In conjunction with blood vessel function, we at least have to consider leakage of fluid/proteins/plasma, resulting in edema/exudate formation as well as thrombogenesis. Blood vessels are also strongly involved in tumor biology. In this aspect, we have neoangiogenesis resulting in pathological vascularization, vascular invasion resulting in release of metastatic cells and the phenomenon of homing resulting in formation of secondary tumors--metastases.
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
authors.forename: Luka
authors.initials: L
authors.lastname: Brcic
authors.forename: Lovorka Batelja
authors.initials: LB
authors.lastname: Vuletic
authors.forename: Danijela
authors.initials: D
authors.lastname: Kolenc
authors.forename: Gorana
authors.initials: G
authors.lastname: Aralica
authors.forename: Marija
authors.initials: M
authors.lastname: Misic
authors.forename: Anita
authors.initials: A
authors.lastname: Zenko
authors.forename: Domagoj
authors.initials: D
authors.lastname: Drmic
authors.forename: Rudolf
authors.initials: R
authors.lastname: Rucman
authors.affiliation: Institute of Pathology, University of Zagreb, School of Medicine, Salata 10, 1000 Zagreb, Croatia. seiwerth@mef.hr.
authors.forename: Predrag
authors.initials: P
authors.lastname: Sikiric
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000473:pathology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000139:chemically induced; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology / Q000502:physiology*; D011506:Proteins / Q000494:pharmacology / Q000502:physiology*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D010446:Peptide Fragments; D011506:Proteins; C083833:BPC 157