title: Enteral nutrition within 48 hours of admission improves clinical outcomes of acute pancreatitis by reducing complications: a meta-analysis.
abstract: BACKGROUND
  Enteral nutrition is increasingly advocated in the treatment of acute pancreatitis, but its timing is still controversial. The aim of this meta-analysis was to find out the feasibility of early enteral nutrition within 48 hours of admission and its possible advantages.
  
  
  RESULTS
  We searched PubMed, EMBASE Databases, Web of Science, the Cochrane library, and scholar.google.com for all the relevant articles about the effect of enteral nutrition initiated within 48 hours of admission on the clinical outcomes of acute pancreatitis from inception to December 2012. Eleven studies containing 775 patients with acute pancreatitis were analyzed. Results from a pooled analysis of all the studies demonstrated that early enteral nutrition was associated with significant reductions in all the infections as a whole (OR 0.38; 95%CI 0.21-0.68, P<0.05), in catheter-related septic complications (OR 0.26; 95%CI 0.11-0.58, P<0.05), in pancreatic infection (OR 0.49; 95%CI 0.31-0.78, P<0.05), in hyperglycemia (OR 0.24; 95%CI 0.11-0.52, P<0.05), in the length of hospitalization (mean difference -2.18; 95%CI -3.48-(-0.87); P<0.05), and in mortality (OR 0.31; 95%CI 0.14-0.71, P<0.05), but no difference was found in pulmonary complications (P>0.05). The stratified analysis based on the severity of disease revealed that, even in predicted severe or severe acute pancreatitis patients, early enteral nutrition still showed a protective power against all the infection complications as a whole, catheter-related septic complications, pancreatic infection complications, and organ failure that was only reported in the severe attack of the disease (all P<0.05).
  
  
  CONCLUSIONS
  Enteral nutrition within 48 hours of admission is feasible and improves the clinical outcomes in acute pancreatitis as well as in predicted severe or severe acute pancreatitis by reducing complications.
authors.affiliation: Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Jie-Yao
authors.initials: JY
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.forename: Guang-Cheng
authors.initials: GC
authors.lastname: Chen
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Yuan
authors.forename: Wa
authors.initials: W
authors.lastname: Zhong
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Zhao
authors.forename: Qi-Kui
authors.initials: QK
authors.lastname: Chen
mesh_terms: D016206:Databases, Bibliographic; D004750:Enteral Nutrition; D006801:Humans; D007902:Length of Stay; D019283:Pancreatitis, Acute Necrotizing / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011183:Postoperative Complications / Q000517:prevention & control*; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome