title: Long-term outcome of placental site trophoblastic tumor in The Netherlands.
abstract: OBJECTIVE
  To evaluate the outcome of 16 cases of placental site trophoblastic tumors (PSTTs) treated throughout The Netherlands.
  
  
  METHODS
  Patients with PSTT between 1991 and 2009 were identified using the nationwide network and registry of histopathology and cytopathology in The Netherlands (PALGA) and medical records.
  
  
  RESULTS
  Data for 16 patients could be retrieved. The median age of the patients was 32 years. In 7 cases the antecedent pregnancy was a miscarriage and in 6, a term delivery. Clinical data on 3 patients could not be retrieved. Six patients were low-risk according to the International Federation of Gynecology and Obstetrics staging system. The median human chorionic gonadotropin (hCG) level was 46 IU/L, but in 4 patients the hCG level was not elevated. In the majority of patients a hysterectomy was performed, and 5 patients needed additional chemotherapy. There was only 1 recurrence and there were no fatalities.
  
  
  CONCLUSIONS
  This study emphasizes the need for an international registration. No fatalities were registered. Because of the low incidence and limited experience of general gynecologists with this disease, there is a preference for centralization of all patients with PSTT regardless of their stage.
authors.affiliation: Department of Obstetrics and Gynecology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands. nienke.v.trommel@catharinaziekenhuis.nl
authors.forename: Nienke E
authors.initials: NE
authors.lastname: van Trommel
authors.forename: Christianne A R
authors.initials: CA
authors.lastname: Lok
authors.forename: Hans
authors.initials: H
authors.lastname: Bulten
authors.forename: Chris M G
authors.initials: CM
authors.lastname: Thomas
authors.forename: Leon F A G
authors.initials: LF
authors.lastname: Massuger
mesh_terms: D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D004107:Dilatation and Curettage; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D009426:Netherlands; D011247:Pregnancy; D012042:Registries; D015996:Survival Rate; D016896:Treatment Outcome; D018245:Trophoblastic Tumor, Placental Site / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery
chemical_list: D006063:Chorionic Gonadotropin