title: Quantitative and qualitative spectral domain optical coherence tomography analysis of subretinal deposits in patients with acute central serous retinopathy.
abstract: OBJECTIVE
  To perform qualitative and quantitative analyses of subretinal protein deposits (PDs), seen in acute central serous retinopathy (CSR) patients, using high-resolution spectral domain optical coherence tomography (SD-OCT), in order to investigate whether the present PDs have any significant impact on best corrected visual acuity (BCVA).
  
  
  METHODS
  Patients diagnosed with acute CSR were included. Using SD-OCT, the following distances/heights were measured: central total retinal thickness, central neurosensory retinal thickness, the vertical and horizontal length of subfoveal subretinal fluid and subfoveal thickness of the PD layer, if present and could be measured.
  
  
  RESULTS
  Thirty-eight patients with acute CSR were included. A significant correlation was found between the subfoveal thickness of the PD layer and baseline/final visual acuities in the eyes (r = 0.60, p ≤ 0.001 and r = 0.45, p = 0.008, respectively).
  
  
  CONCLUSIONS
  The thickness of subfoveal PDs at baseline appears to be an important parameter related to the BCVA and time of CSR resolution.
authors.affiliation: The Einhorn Clinical Research Center and The Bendheim Family Retina Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY 10003, USA.
authors.forename: Gennady
authors.initials: G
authors.lastname: Landa
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Barnett
authors.forename: Patricia M T
authors.initials: PM
authors.lastname: Garcia
authors.forename: Katy W
authors.initials: KW
authors.lastname: Tai
authors.forename: Richard B
authors.initials: RB
authors.lastname: Rosen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000378:metabolism; D005136:Eye Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D012160:Retina / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
chemical_list: D005136:Eye Proteins