title: Effect of bolus injection of 20 ml saline with arm elevation on the onset time of vecuronium administered via a peripheral vein: a randomised controlled trial.
abstract: We investigated whether a bolus injection of 20 ml saline with arm elevation might shorten the onset time of vecuronium administered via a dorsal hand vein. Thirty patients were randomly allocated to the bolus saline group or control group. General anaesthesia was induced and maintained with remifentanil and propofol. Vecuronium 0.1 mg.kg(-1) was administered to all patients, followed in the treatment group by bolus injection of 20 ml saline and arm elevation. Response to train-of-four stimulation was measured by acceleromyography at the adductor pollicis muscle. The mean (SD) lag time was 47.2 (14.5) s in the bolus saline group and 67.9 (12.2) s in the control group (p = 0.0002). The time to 95% block of T1 was 104.6 (29.9) s in the bolus saline group and 128.3 (15.8) s in the control group (p = 0.011). Bolus saline injection results in shortened lag time and onset time of neuromuscular block with vecuronium.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nitahara
authors.forename: Y
authors.initials: Y
authors.lastname: Sugi
authors.forename: K
authors.initials: K
authors.lastname: Shigematsu
authors.forename: G
authors.initials: G
authors.lastname: Kusumoto
authors.forename: S
authors.initials: S
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Higa
mesh_terms: D061725:Accelerometry / Q000379:methods; D000293:Adolescent; D000328:Adult; D000368:Aged; D001132:Arm; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics*; D056888:Patient Positioning / Q000379:methods*; D012965:Sodium Chloride / Q000494:pharmacology*; D013995:Time; D014673:Vecuronium Bromide / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D012965:Sodium Chloride; D014673:Vecuronium Bromide