title: A literature review of cost-effectiveness analyses of prostate-specific antigen test in prostate cancer screening.
abstract: Prostate cancer is the most common non-skin cancer in American men, and prostate-specific antigen (PSA) testing is its common screening procedure. In May 2012, the US Preventive Services Task Force recommended against PSA-based screening. These recommendations contradict the current recommendations of other organizations such as the American Urological Association. The authors conducted a systematic review of PubMed, EMBASE and Cochrane to examine the published literature reporting the cost-effectiveness of PSA-based screening. The authors found ten studies each for US and non-US jurisdiction population. All reviewed studies concluded PSA-based screening to be cost effective in younger men (≤60 years of age) and at higher PSA levels (≥3 ng/ml). Further cost-effectiveness analyses reflecting latest clinical practice and current perspectives regarding adverse outcomes of potentially unnecessary treatment are required, especially from the US government perspective.
authors.affiliation: Pharmacoeconomics, Epidemiology, Pharmaceutical Policy and Outcomes Research (PEPPOR) Program, Department of Pharmacy Practice and Administrative Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM, USA. vgarg@salud.unm.edu
authors.forename: Vishvas
authors.initials: V
authors.lastname: Garg
authors.forename: Ning Yan
authors.initials: NY
authors.lastname: Gu
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Borrego
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Raisch
mesh_terms: D000367:Age Factors; D003362:Cost-Benefit Analysis; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood* / Q000191:economics; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000191:economics / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D019564:Unnecessary Procedures / Q000009:adverse effects
chemical_list: D017430:Prostate-Specific Antigen