title: Aging well with a little wine and a good clock.
abstract: Age-related decline in mammalian circadian rhythm has been recognized for decades, but the underlying molecular mechanisms have remained elusive. In this issue of Cell, Chang and Guarente use brain-specific SIRT1 knockout mice and transgenic mice overexpressing SIRT1 to develop an enticing model for how SIRT1 helps maintain the robustness of the aging circadian clock.
authors.affiliation: Department of Animal Sciences, Rutgers, the State University of New Jersey, New Brunswick, NJ 08904, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Belden
authors.forename: Jay C
authors.initials: JC
authors.lastname: Dunlap
mesh_terms: D000375:Aging; D000818:Animals; D057906:Circadian Clocks; D008297:Male; D056564:Sirtuin 1 / Q000378:metabolism*; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*
chemical_list: C470545:Sirt1 protein, mouse; D056564:Sirtuin 1