title: Inflammatory proteins in plasma are associated with severity of Alzheimer's disease.
abstract: Markers of Alzheimer's disease (AD) are being widely sought with a number of studies suggesting blood measures of inflammatory proteins as putative biomarkers. Here we report findings from a panel of 27 cytokines and related proteins in over 350 subjects with AD, subjects with Mild Cognitive Impairment (MCI) and elderly normal controls where we also have measures of longitudinal change in cognition and baseline neuroimaging measures of atrophy. In this study, we identify five inflammatory proteins associated with evidence of atrophy on MR imaging data particularly in whole brain, ventricular and entorhinal cortex measures. In addition, we observed six analytes that showed significant change (over a period of one year) in people with fast cognitive decline compared to those with intermediate and slow decline. One of these (IL-10) was also associated with brain atrophy in AD. In conclusion, IL-10 was associated with both clinical and imaging evidence of severity of disease and might therefore have potential to act as biomarker of disease progression.
authors.affiliation: King's College London and National Institute for Health Research-NIHR, Biomedical Research Centres at South London and Maudsley NHS Foundation Trust and Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
authors.forename: Rufina
authors.initials: R
authors.lastname: Leung
authors.forename: Petroula
authors.initials: P
authors.lastname: Proitsi
authors.forename: Andrew
authors.initials: A
authors.lastname: Simmons
authors.forename: Katie
authors.initials: K
authors.lastname: Lunnon
authors.forename: Andreas
authors.initials: A
authors.lastname: Güntert
authors.forename: Deborah
authors.initials: D
authors.lastname: Kronenberg
authors.forename: Megan
authors.initials: M
authors.lastname: Pritchard
authors.forename: Magda
authors.initials: M
authors.lastname: Tsolaki
authors.forename: Patrizia
authors.initials: P
authors.lastname: Mecocci
authors.forename: Iwona
authors.initials: I
authors.lastname: Kloszewska
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.forename: Lars-Olaf
authors.initials: LO
authors.lastname: Wahlund
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000150:complications / Q000473:pathology*; D001284:Atrophy / Q000097:blood / Q000209:etiology / Q000473:pathology*; D015415:Biomarkers / Q000097:blood*; D001921:Brain / Q000378:metabolism*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology / Q000473:pathology*; D015331:Cohort Studies; D016207:Cytokines / Q000378:metabolism*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators