title: β-Arrestins in the immune system.
abstract: β-Arrestins regulate G protein-coupled receptors through receptor desensitization while also acting as signaling scaffolds to facilitate numerous effector pathways. Recent studies have provided evidence that β-arrestins play a key role in inflammatory responses. Here, we summarize these advances on the roles of β-arrestins in immune regulation and inflammatory responses under physiological and pathological conditions, with an emphasis on translational implications of β-arrestins on human diseases.
authors.affiliation: Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Dianhua
authors.initials: D
authors.lastname: Jiang
authors.forename: Ting
authors.initials: T
authors.lastname: Xie
authors.forename: Jiurong
authors.initials: J
authors.lastname: Liang
authors.forename: Paul W
authors.initials: PW
authors.lastname: Noble
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D019390:Arrestins / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D007113:Immunity, Innate; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D000071557:beta-Arrestins
chemical_list: D019390:Arrestins; D000071557:beta-Arrestins