title: A longitudinal analysis of the effects of a DRD4 polymorphism on marijuana use.
abstract: The current study used a variable- and person-centered approach to examine whether a DRD4 polymorphism explained within-individual differences in frequency of marijuana use from adolescence into emerging adulthood. Data were analyzed from 1897 respondents from the genetic subsample of the National Longitudinal Study of Adolescent Health (Add Health) at waves I (ages 13-17), II (ages 14-18), and III (ages 21-25). Latent class growth model results revealed that marijuana use was characterized by four trajectories (non-users/experimenters, increasers, desisters, and chronic users), and that the DRD4 polymorphism differentiated increasers from non-users/experimenters. Overall, the results suggested that the DRD4 polymorphism may be relevant to differences in the developmental trajectories of marijuana use.
authors.affiliation: Department of Criminology and Criminal Justice, Western Carolina University, Cullowhee, NC 28723, United States. Electronic address: jvaske@email.wcu.edu.
authors.forename: Jamie
authors.initials: J
authors.lastname: Vaske
authors.forename: Danielle
authors.initials: D
authors.lastname: Boisvert
authors.forename: John Paul
authors.initials: JP
authors.lastname: Wright
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Beaver
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003657:Decision Making / Q000502:physiology; D003863:Depression / Q000209:etiology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008385:Marijuana Smoking / Q000235:genetics* / Q000503:physiopathology; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D057566:Self Report; D055815:Young Adult
chemical_list: C493599:DRD4 protein, human; D050638:Receptors, Dopamine D4
keywords: Add Health; DRD4; Marijuana use; Trajectory