title: Lobar lung transplantation: a relevant surgical option in the current era of lung allocation score.
abstract: BACKGROUND
  With the implementation of the lung allocation score (LAS) system, an increased number of critically ill patients are considered for transplantation. However, LAS does not take size matching between donor and recipient lungs into consideration. Mortality on the waiting list is high (as high as 25%) for short-stature patients and for patients with restrictive lung disease. Here, we review our experience using cadaveric lobar lung transplantation as a surgical option in an attempt to decrease mortality while waiting.
  
  
  METHODS
  We retrospectively reviewed patients with end-stage lung diseases and an LAS greater than 70 who underwent cadaveric lobar lung transplantation between 2010 and 2012 (n = 25) at our institution, a high-volume lung transplant center. Anatomic lobectomy was performed on all donor lungs before double lung transplantation.
  
  
  RESULTS
  Median LAS was 85.6 (range, 72 to 94). Average waiting time after the patients' LAS was updated to greater than 70 was 10 days (range, 1 to 41). There were 2 in-hospital deaths. The 90-day and 1-year survivals were 88% and 76%, respectively. Patient major comorbidities included severe primary graft dysfunction requiring postoperative extracorporeal membrane oxygenation (7 patients), acute renal insufficiency (4 patients), and bleeding requiring reoperation (4 patients). No technical problems were identified, and repeated bronchoscopy demonstrated satisfactory healing of the bronchial stump after lobectomy. The average posttransplant peak for forced expiratory volume in 1 second was 85%.
  
  
  CONCLUSIONS
  Our initial experience supports the option of lobar lung transplantation for critically ill patients whose opportunities for transplant are limited by their stature. Long-term functional studies are warranted.
authors.affiliation: Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA. shigemuran@upmc.edu
authors.forename: Norihisa
authors.initials: N
authors.lastname: Shigemura
authors.forename: Jonathan
authors.initials: J
authors.lastname: D'Cunha
authors.forename: Jay K
authors.initials: JK
authors.lastname: Bhama
authors.forename: Akira
authors.initials: A
authors.lastname: Shiose
authors.forename: Ashraf
authors.initials: A
authors.lastname: Abou El Ela
authors.forename: Amy
authors.initials: A
authors.lastname: Hackmann
authors.forename: Diana
authors.initials: D
authors.lastname: Zaldonis
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Toyoda
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Pilewski
authors.forename: James D
authors.initials: JD
authors.lastname: Luketich
authors.forename: Christian A
authors.initials: CA
authors.lastname: Bermudez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D046148:Donor Selection / Q000592:standards*; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D055815:Young Adult
keywords: 12