title: Simultaneous determination of sitagliptin and metformin in their pharmaceutical formulation.
abstract: Two simple, accurate, and rapid methods were developed for simultaneous determination of sitagliptin phosphate and metformin hydrochloride in their pharmaceutical formulation. The first is a TLC method coupled with densitometry. The second is an HPLC method using a C18 column. The selectivity of the proposed methods was checked using laboratory-prepared mixtures. The proposed methods were successfully applied to the analysis of sitagliptin phosphate and metformin hydrochloride in bulk form and in their pharmaceutical formulation without interference from other additives.
authors.affiliation: Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr El-Aini St, ET-11562 Cairo, Egypt. mamdouhreda75@yahoo.com
authors.forename: Mamdouh R
authors.initials: MR
authors.lastname: Rezk
authors.forename: Safa'a M
authors.initials: SM
authors.lastname: Riad
authors.forename: Ghada Y
authors.initials: GY
authors.lastname: Mahmoud
authors.forename: Abdel-Aziz El Bayoumi
authors.initials: AA
authors.lastname: Abdel Aleem
mesh_terms: D007004:Hypoglycemic Agents / Q000737:chemistry*; D008687:Metformin / Q000737:chemistry*; D015394:Molecular Structure; D011719:Pyrazines / Q000737:chemistry*; D000068900:Sitagliptin Phosphate; D013607:Tablets; D014230:Triazoles / Q000737:chemistry*
chemical_list: D007004:Hypoglycemic Agents; D011719:Pyrazines; D013607:Tablets; D014230:Triazoles; D008687:Metformin; D000068900:Sitagliptin Phosphate