title: Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus.
abstract: Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce virus from DNA infections in immunocompromised mice. In these early studies, we have demonstrated both primary and secondary infections, expanded tissue tropism, and extensive dysplasia.
authors.affiliation: Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Cladel
authors.forename: Lynn R
authors.initials: LR
authors.lastname: Budgeon
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Cooper
authors.forename: Karla K
authors.initials: KK
authors.lastname: Balogh
authors.forename: Jiafen
authors.initials: J
authors.lastname: Hu
authors.forename: Neil D
authors.initials: ND
authors.lastname: Christensen
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D004279:DNA, Viral / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D006651:Histocytochemistry; D016867:Immunocompromised Host; D051379:Mice; D008819:Mice, Nude; D009333:Neck / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology; D012867:Skin / Q000473:pathology / Q000821:virology; D014161:Transduction, Genetic; D014170:Transformation, Genetic; D014621:Vagina / Q000473:pathology / Q000821:virology; D056189:Viral Tropism; D014844:Vulva / Q000473:pathology / Q000821:virology
chemical_list: D004279:DNA, Viral