title: Acute and long-term treatment outcome in depressed inpatients with vs. without anxious features: results of a one-year follow-up study.
abstract: BACKGROUND
  Anxious depression (AD) is common in patients with unipolar depression. It remains unclear if they have a higher level of depressive symptoms, a higher risk of non-response, a poorer prognosis and a higher relapse rate compared to non-anxious depressed (non-AD) patients.
  
  
  METHODS
  168 patients took part in all three measurement points: (1) intake, (2) discharge and (3) follow-up. Patients fulfilled the criteria for anxious depression if they had a baseline score >7 on the anxiety/somatisation factor of the Hamilton Rating Scale for Depression (HRSD). Patients with AD and non-AD were compared regarding symptom reduction from intake to discharge as well as from discharge to one year after discharge. Primary outcome measure was the HRSD.
  
  
  RESULTS
  The prevalence of AD was considerably high (81%). At intake, patients with AD had a significant higher score in the modified HRSD (M=20.67±4.12 vs. M=14.35±5.06). Both patient groups showed a significant and comparable intake-to-discharge symptom reduction in all inventories. Remission rates at discharge did not differ between AD and non-AD patients. At 1-year follow-up, AD patients showed a similar symptom severity compared to non-AD patients.
  
  
  CONCLUSIONS
  Symptoms of anxiety are common in depressive disorders are associated with higher depressive symptoms at the beginning of treatment. Acute and longer-term treatment outcome of AD patients was comparable to that of non-AD patients.
  
  
  CONCLUSIONS
  Limitations of this study are the naturalistic design, treatment was not standardized and comorbid anxiety disorders were not assed using a structured interview.
authors.affiliation: Charité University Medicine Berlin, Campus Mitte, Department of Psychiatry and Psychotherapy, Berlin, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Köhler
authors.forename: Theresa
authors.initials: T
authors.lastname: Unger
authors.forename: Sabine
authors.initials: S
authors.lastname: Hoffmann
authors.forename: Bruno
authors.initials: B
authors.lastname: Steinacher
authors.forename: Thomas
authors.initials: T
authors.lastname: Fydrich
mesh_terms: D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000453:epidemiology*; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007297:Inpatients; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D015995:Prevalence; D012008:Recurrence; D016896:Treatment Outcome
keywords: Acute treatment; Anxiety; Anxious depression; Depression; Follow-up; Treatment outcome