title: Graphene nanoparticles as pseudostationary phase for the electrokinetic separation of nonsteroidal anti-inflammatory drugs.
abstract: The exceptional properties of graphene (G) were exploited here to facilitate capillary electrokinetic separations. Two types of commercially available G consisting of nanoparticles containing-one to three and-four to six G sheets, respectively, were compared for this purpose. Both proved effective in separating the arylpropyl derivatives of nonsteroidal anti-inflammatory drugs. The highest resolution and shortest migration times were obtained with G containing high amount of single and double G nanosheets. G affords higher resolution than other types of nanoparticles; stable suspensions can be easily prepared and used as BGE without the need of adding an additional surfactant. This results in a high reproducibility in migration times and stability in background noise. The LOD and LOQ obtained by using G nanoparticles as pseudostationary phases spanned the range 0.29-1.18 mg/L and 0.95-3.95 mg/L, respectively, and the RSD was less than 4.7% in all instances.
authors.affiliation: Department of Analytical Chemistry, University of Córdoba, Campus of Rabanales, Córdoba, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Benítez-Martínez
authors.forename: Bartolomé M
authors.initials: BM
authors.lastname: Simonet
authors.forename: Miguel
authors.initials: M
authors.lastname: Valcárcel
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D016014:Linear Models; D053758:Nanoparticles / Q000737:chemistry*; D010666:Phenylpropionates / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D015203:Reproducibility of Results
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; D006108:Graphite
keywords: Capillary electrophoresis; Graphene; Nonsteroidal anti-inflammatory drugs; Pseudostationary phase