title: A Janus-faced role of the unfolded protein response in antitumor immunity.
abstract: The unfolded protein response (UPR) has been established as a cell-intrinsic mechanism of survival for malignant cells facing microenvironmental stressors. Recent evidence indicates that the UPR also modulates antitumor immunity. Here, we discuss the bi-faced role of the UPR as it both promotes and antagonizes antitumor T-cell immunity.
authors.affiliation: The Laboratory of Immunology; Department of Medicine and Moores Cancer Center; University of California; San Diego, CA USA.
authors.forename: Navin R
authors.initials: NR
authors.lastname: Mahadevan
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Rodvold
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zanetti
keywords: T cell immunity; antigen presentation; immune surveillance; tumor ploidy; tumor unfolded protein response