title: Is there a rationale for an anesthesiologist's role against cancer recurrence?
abstract: Growth of tumors can accelerate during the peri-operative period. Accordingly, early relapse of cancer occurs in some patients during the first two postoperative years. Temporal and biologic analyses of cancer pathophysiology suggest a link between peri-operative pathophysiological changes and acceleration of tumor growth. Understanding the role of inflammation and its consequences (i.e., immune response, growth factors, dissemination of tumor cells) could lead to define a role of anesthesiologists in reducing cancer recurrence following surgery. We argue for peri-operative pharmacological interventions to reduce cancer relapse, with a focus on non-steroidal anti-inflammatory drugs.
authors.affiliation: Department of Anesthesiology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium. forgetpatrice@yahoo.fr
authors.forename: P
authors.initials: P
authors.lastname: Forget
authors.forename: P G
authors.initials: PG
authors.lastname: Coulie
authors.forename: M
authors.initials: M
authors.lastname: Retsky
authors.forename: R
authors.initials: R
authors.lastname: Demicheli
authors.forename: J P
authors.initials: JP
authors.lastname: Machiels
authors.forename: M
authors.initials: M
authors.lastname: De Kock
mesh_terms: D000776:Anesthesiology / Q000379:methods* / Q000639:trends; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000517:prevention & control*; D009369:Neoplasms / Q000150:complications / Q000517:prevention & control*; D010819:Physician's Role; D055502:Secondary Prevention
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal