title: Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report.
abstract: Acetaminophen overdose is the most rapidly growing cause of fulminant hepatic failure in Western countries. Pregnant women are counseled that acetaminophen is safe during pregnancy and an alternative to nonsteroidal anti-inflammatory medications. This report describes a case of acetaminophen overdose during the second trimester of pregnancy with resultant fulminant hepatic failure requiring liver transplantation. The fetus was previable at the time of liver transplantation, and methods to preserve viability during and after transplantation are discussed. Despite the best attempts of the team, the fetus expired. The challenges and outcomes of fulminant hepatic failure in pregnancy are discussed in detail.
authors.affiliation: Department of Transplant and Hepatobiliary Surgery, University of California at San Diego, CA 92103, USA. kfranko@ucsd.edu
authors.forename: K R
authors.initials: KR
authors.lastname: Franko
authors.forename: K L
authors.initials: KL
authors.lastname: Mekeel
authors.forename: D
authors.initials: D
authors.lastname: Woelkers
authors.forename: A
authors.initials: A
authors.lastname: Khanna
authors.forename: A W
authors.initials: AW
authors.lastname: Hemming
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D000328:Adult; D062787:Drug Overdose; D005260:Female; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced* / Q000601:surgery; D016031:Liver Transplantation; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D055815:Young Adult
chemical_list: D000082:Acetaminophen