title: Thymoglobulin and its use in renal transplantation: a review.
abstract: Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a polyclonal antibody which has been used in the field of transplantation over the last four decades. With an initial hesitancy, it is widely used now in the prevention and treatment of rejection following renal transplantation. Thymoglobulin's lack of nephrotoxic properties (unlike calcineurin inhibitors) may potentiate it to be a very useful induction therapy during the early days following transplantation, particularly in a donation after circulatory death programme. More recently its role in conjunction with inhibitors of terminal complement activation has been shown to be beneficial in cross-match-positive transplantation. This review article consolidates up-to-date available evidence to address the therapeutic role of thymoglobulin in immunological tolerance, ischemia perfusion, live donor transplantation, delayed graft function, prevention and treatment of rejection, graft survival and post-transplant lymphoproliferative disorder following renal transplantation.
authors.affiliation: Department of General and Transplant Surgery, Derriford Hospital, Plymouth, UK. umasurgeon@gmail.com
authors.forename: Umasankar Mathuram
authors.initials: UM
authors.lastname: Thiyagarajan
authors.forename: Amirthavarshini
authors.initials: A
authors.lastname: Ponnuswamy
authors.forename: Atul
authors.initials: A
authors.lastname: Bagul
mesh_terms: D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology; D023001:Transplantation Tolerance
chemical_list: D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; C512542:thymoglobulin