title: Garlic oil suppressed the hematological disorders induced by chemotherapy and radiotherapy in tumor-bearing mice.
abstract: Although the anticancer effects of garlic and its products have been demonstrated by a variety of studies; however, few studies were conducted to investigate the effects of garlic on the adverse effects of chemo/radiotherapy. In order to clarify the above question and make a more comprehensive understanding of the anticancer effects of garlic, tumor xenograft mice model was established by subcutaneous injection of H22 tumor cells, and was used for the investigation of effects of garlic oil (GO) on the chemo/radiotherapy. In the chemotherapy test, tumor-bearing mice were treated with cyclophosphamide (CTX) or CTX plus GO (25 or 50 mg/kg bw) for 14 d, while the mice received a single 5 Gy total body radiation or radiation plus GO (25 or 50 mg/kg bw) in radiotherapy test. The results showed that GO did not increase the tumor inhibitory rate of CTX/radiation, which indicated that GO could not enhance the chemo/radiosensitivity of cancer cells. However, the decrease of the peripheral total white blood cells (WBCs) count induced by CTX/radiation was significantly suppressed by GO cotreatment. Furthermore, GO cotreatment significantly inhibited the decrease of the DNA contents and the micronuclei ratio of the bone marrow. Lastly, the reduction of the endogenous spleen colonies induced by CTX/radiation was significantly suppressed by GO cotreatment. These findings support the idea that GO consumption may benefit for the cancer patients receiving chemotherapy or radiotherapy.
authors.affiliation: School of Public Health, Shandong Univ., 44 Wenhua West Road, Shandong Province, Jinan City, 250012, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zeng
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Cui-Li
authors.initials: CL
authors.lastname: Zhang
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Yu
authors.forename: Zhen-Ping
authors.initials: ZP
authors.lastname: Zhu
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Zhao
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Xie
mesh_terms: D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D045744:Cell Line, Tumor; D003114:Colony-Forming Units Assay; D003520:Cyclophosphamide / Q000009:adverse effects; D004195:Disease Models, Animal; D005737:Garlic / Q000737:chemistry*; D006402:Hematologic Diseases / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D010938:Plant Oils / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D013440:Sulfides / Q000494:pharmacology*
chemical_list: D000498:Allyl Compounds; D000970:Antineoplastic Agents; D010938:Plant Oils; D013440:Sulfides; C038491:allyl sulfide; D003520:Cyclophosphamide