title: Biophysical characterization of bladder cancer cells with different metastatic potential.
abstract: Specific membrane capacitance (SMC) and Young's modulus are two important parameters characterizing the biophysical properties of a cell. In this work, the SMC and Young's modulus of two cell lines, RT4 and T24, corresponding to well differentiated (low grade) and poorly differentiated (high grade) urothelial cell carcinoma (UCC), respectively, were quantified using microfluidic and AFM measurements. Quantitative differences in SMC and Young's modulus values of the high-grade and low-grade UCC cells are, for the first time, reported.
authors.affiliation: Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, M5S 3G8, Canada.
authors.forename: Haijiao
authors.initials: H
authors.lastname: Liu
authors.forename: Qingyuan
authors.initials: Q
authors.lastname: Tan
authors.forename: William R
authors.initials: WR
authors.lastname: Geddie
authors.forename: Michael A S
authors.initials: MA
authors.lastname: Jewett
authors.forename: Nigel
authors.initials: N
authors.lastname: Phillips
authors.forename: Danbing
authors.initials: D
authors.lastname: Ke
authors.forename: Craig A
authors.initials: CA
authors.lastname: Simmons
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
mesh_terms: D002454:Cell Differentiation; D045744:Cell Line, Tumor; D055119:Elastic Modulus; D006801:Humans; D008564:Membrane Potentials; D046210:Microfluidic Analytical Techniques; D018625:Microscopy, Atomic Force; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D001749:Urinary Bladder Neoplasms / Q000503:physiopathology*