title: [Diabetes induced by multiple low doses of STZ can be spontaneously recovered in adult mice].
abstract: In a previous study, we observed that multiple low doses of streptozotocin (STZ) can induce spontaneous restoration of normoglycemia in adult mouse diabetes models. In the present study, we sought to identify when spontaneous recovery from diabetes occurs and to disclose the changes in the diabetic data of diabetic mice induced by multiple low doses of streptozotocin (MLD-STZ mice). After inducing type 1 diabetes mellitus, radioimmunoassay, indirect immunofluorescence and hematoxylin-eosin staining were used to determine the diabetic data of MLD-STZ mice. In MLD-STZ mice, the diabetic indicators, including food intake, water consumption, body weight, blood glucose level and serum insulin concentration, developed gradually until week 20. Thereafter, the symptoms of diabetes gradually improved. By the week 36, although body weight and β cell masses remained significantly different between the MLD-STZ mice and the age-matched control animals, food intake, water consumption, blood glucose levels and serum insulin concentrations had all returned to normal levels, and no lymphocytic infiltrations were observed in pancreatic islets. This data demonstrates that MLD-STZ can induce spontaneous recovery from diabetes mellitus in adult mice, suggesting further research into the processes by which normoglycemia is recovered.
authors.affiliation: Department of Anatomy and Histo-Embryology, Laboratory of Key Discipline of Shandong, Weifang Medical University, Weifang 261053, China. lirujiang@wfmc.edu.cn.
authors.forename: Ru-Jiang
authors.initials: RJ
authors.lastname: Li
authors.forename: Shu-Dong
authors.initials: SD
authors.lastname: Qiu
authors.forename: Hong
authors.initials: H
authors.lastname: Tian
authors.forename: Sheng-Wei
authors.initials: SW
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology*; D004195:Disease Models, Animal; D004304:Dosage Forms; D004435:Eating; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020127:Recovery of Function / Q000187:drug effects*; D013311:Streptozocin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D001786:Blood Glucose; D004304:Dosage Forms; D007328:Insulin; D013311:Streptozocin
keywords: Blood glucose; Mouse; Streptozotocin; Type 1 diabetes mellitus; β cell mass