title: [Susceptible and resistant factors in neuro-immune disease].
abstract: Neuro-immune diseases (NIDs) are caused by a complex interaction between multiple genetic and environmental factors, both of which can have some impacts on susceptibility or resistance to each disease. Remarkable advance in genome technology made possible the effective screening of thousands of single nucleotide polymorphisms in thousands of samples. Additionally, epidemiological science, supported by microbiology, immunology and biochemistry, has revealed many possible environmental factors. Integrating genetic and environmental research data will pave the way to inform and personalize therapeutic decision-making in NIDs. This review aims to discuss susceptible and resistant factors that have attracted the most attention in the recent years, especially focusing on multiple sclerosis, which is one of the most common NIDs.
authors.affiliation: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Shinya
authors.initials: S
authors.lastname: Sato
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kira
mesh_terms: D000818:Animals; D020274:Autoimmune Diseases of the Nervous System / Q000235:genetics* / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology*; D004777:Environment; D006801:Humans; D015213:Neuroimmunomodulation / Q000235:genetics; D012307:Risk Factors