title: Clinicopathological and prognostic significance of p27 expression in oral squamous cell carcinoma: a meta-analysis.
abstract: Despite being already known that p27 can regulate cell proliferation, cell motility and apoptosis, the role of p27 expression in oral squamous cell carcinoma (OSCC) remains controversial. The purpose of this study was to comprehensively evaluate, with a meta-analysis, the clinicopathological and prognostic role of p27 expression in OSCC. A meta-analysis of eligible studies was performed to assess the effects of p27 expression on clinicopathological parameters and overall survival (OS) in patients with OSCC, using pooled relative risks with 95% confidence intervals. Heterogeneity and publication bias were also assessed. Fourteen studies involving a total of 1,010 patients met the inclusion criteria. Low p27 expression was significantly associated with advanced TNM stage (p<0.001), worse histology (p=0.025), and lymph node metastasis (p<0.001), but not with tumor size (p=0.181). The pooled RR of 0.743 (p=0.002) suggested that low p27 expression has a poor prognosis in patients with OSCC. A significant heterogeneity among studies was detected for lymph node status (χ(2)=34.60, I(2)=68.2%, p<0.001) and OS (χ(2)=14.86, I(2)=39.4%, p=0.095). We did not detect a significant publication bias in this meta-analysis. Our meta-analysis suggests that p27 expression status might be useful as a predictive biomarker in clinical practice, and might potently predict OS in OSCC patients.
authors.affiliation: Department of Oral Maxillofacial Surgery, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi - China and Key Laboratory of Environment and Genes Related to Diseases, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi - China.
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.forename: Wanjie
authors.initials: W
authors.lastname: Gu
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zheng
authors.forename: Wenhao
authors.initials: W
authors.lastname: Ren
authors.forename: Su'e
authors.initials: S
authors.lastname: Chang
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Wang
authors.forename: Shaoming
authors.initials: S
authors.lastname: Li
authors.forename: Tusheng
authors.initials: T
authors.lastname: Song
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
authors.forename: Keqian
authors.initials: K
authors.lastname: Zhi
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000096:biosynthesis*; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor; D050760:Cyclin-Dependent Kinase Inhibitor p27