title: Copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagents.
abstract: The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310028, P. R. China.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Xia
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Liu
authors.forename: Yuejiao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Wanzhi
authors.initials: W
authors.lastname: Chen
mesh_terms: D000577:Amides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry*
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D007202:Indicators and Reagents; D010545:Peroxides; D003300:Copper