title: Structural and some medicinal characteristics of the copper(II)-hydroxychloroquine complex.
abstract: In the first phase of this study, the binding of hydroxychloroquine to the copper(II) cation is examined using liquid chromatography-mass spectrometry (LC-MS), matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS), Fourier transform-ion cyclotron resonance spectrometry (FT-ICR) and nuclear magnetic resonance ((1)H and (13)C NMR) in one and two dimensions. The data suggest the metal-ligand complex is a polarity adaptive molecule. In the second phase of the study, the complexes activity is tested against the National Cancer Institute's 60 cell line panel. Its anti-cancer activity is compared to quinine, Cu(II)-quinine and hydroxychloroquine. It serves as a base line for future anti-cancer complexes in which hydroxychloroquine is utilized for its ability to impact cell autophagy.
authors.affiliation: Department of Chemistry, Valdosta State University, Valdosta, GA 31698, USA. tmanning@valdosta.edu
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Manning
authors.forename: Thomas
authors.initials: T
authors.lastname: Leggett
authors.forename: Dustin
authors.initials: D
authors.lastname: Jenkins
authors.forename: Ivan
authors.initials: I
authors.lastname: Furtado
authors.forename: Dennis
authors.initials: D
authors.lastname: Phillips
authors.forename: Greg
authors.initials: G
authors.lastname: Wylie
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Bythell
authors.forename: Fengli
authors.initials: F
authors.lastname: Zhang
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D003300:Copper / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006886:Hydroxychloroquine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D056831:Coordination Complexes; D006886:Hydroxychloroquine; D003300:Copper