title: Synthesis of protected (1-phenyl-1h-pyrrol-2-yl)-alkane-1-amines from phenylnitroso Diels-Alder adducts with 1,2-dihydropyridines.
abstract: The reductive cleavage of nitrosobenzene-derived cycloadducts with appropriately protected 1,2-dihydropyridines allows a novel and simple obtainment of substituted N-[1-(1-phenyl-1H-pyrrol-2-yl)alkylamides. This synthesis can also be carried out in a very simple, mild, and practical one-pot procedure without isolation of the corresponding nitrosobenzene cycloadduct by means of catalytic amounts of CuCl.
authors.affiliation: Dipartimento di Farmacia, Sede di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Berti
authors.forename: Valeria
authors.initials: V
authors.lastname: Di Bussolo
authors.forename: Mauro
authors.initials: M
authors.lastname: Pineschi
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D004095:Dihydropyridines / Q000737:chemistry*; D015394:Molecular Structure; D009603:Nitroso Compounds / Q000737:chemistry*
chemical_list: D000473:Alkanes; D000588:Amines; D004095:Dihydropyridines; D009603:Nitroso Compounds