title: In vitro selective inhibitory effect of 8-hydroxyquinoline against bifidobacteria and clostridia.
abstract: 8-Hydroxyquinoline (8HQ) inhibited Clostridium tertium, Clostridium clostridioforme, Clostridium difficile and Clostridium perfringens in vitro with MICs of 8, 16, 32 and 32 μg/mL, respectively. In contrast, MICs of most bifidobacteria (84%) were 512 μg/mL or higher. Thus, 8HQ could be used as anti-clostridial agent or in selective media for bifidobacteria isolation.
authors.affiliation: Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamycka 129, 165 21 Prague 6-Suchdol, Czech Republic. novakovajitka@its.czu.cz
authors.forename: Jitka
authors.initials: J
authors.lastname: Novakova
authors.forename: Eva
authors.initials: E
authors.lastname: Vlkova
authors.forename: Bela
authors.initials: B
authors.lastname: Bonusova
authors.forename: Vojtech
authors.initials: V
authors.lastname: Rada
authors.forename: Ladislav
authors.initials: L
authors.lastname: Kokoska
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001644:Bifidobacterium / Q000187:drug effects* / Q000302:isolation & purification; D003013:Clostridium / Q000187:drug effects* / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology*; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D015125:Oxyquinoline / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015125:Oxyquinoline
keywords: 8-Quinolinol; Antimicrobial activity; Bifidobacterium; Clostridium; Selectivity