title: Late adult onset optic pathway astrocytoma.
abstract: A 70-year-old man presented with left-sided eye pain, impaired vision and restricted left ocular motility, later developing progressive visual decline with development of ataxia and incontinence. Fundoscopic examination revealed significant optic nerve head edema and hemorrhage on the left eye. Neuroimaging revealed an optic pathway mass, extending from the right optic nerve to the chiasm, which enlarged on serial imaging. After surgical excision of the mass, pathology showed a grade III astrocytoma. The patient died 16 months after presentation, which is longer than previously reported for late adult onset optic pathway astrocytoma. We believe that neuroimaging and pathological studies should be performed early in such patients to allow early diagnosis and intervention.
authors.affiliation: Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.forename: Sandy
authors.initials: S
authors.lastname: Zhang-Nunes
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhu
authors.forename: Xun
authors.initials: X
authors.lastname: Xu
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Sun
authors.forename: Yuncheng
authors.initials: Y
authors.lastname: Wu
mesh_terms: D017668:Age of Onset; D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D020339:Optic Nerve Glioma / Q000473:pathology* / Q000601:surgery; D014795:Visual Pathways / Q000473:pathology* / Q000601:surgery
keywords: Aged; Neuroimaging; Optic pathway glioma; Pathology