title: Acute kidney injury in a patient with nephrotic syndrome due to focal segmental glomerular nephritis induced by a single oral administration of high-dose bisphosphonate (minodronate).
abstract: We herein report the case of a 75-year-old man who developed an increased serum creatinine level (4.93 mg/dL) and oliguria with massive proteinuria (7.14 g/day) on the second day after a single oral administration of high-dose (56 mg) minodronate. The histology of a renal biopsy showed one area of glomerular sclerosis among 20 glomeruli with global foot process effacement of podocytes and mild infiltration of lymphocytes and eosinophils into the interstitial space. Acute kidney injury in nephrotic syndrome due to focal segmental glomerular sclerosis induced by minodronate was diagnosed. Following cessation of minodronate without the administration of immunosuppressive agents, the patient's renal function and proteinuria markedly improved.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Komada
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Morishita
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kitamura
authors.forename: Kana
authors.initials: K
authors.lastname: Iwazu
authors.forename: Akihiko
authors.initials: A
authors.lastname: Numata
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Tetsu
authors.initials: T
authors.lastname: Akimoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Saito
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ando
authors.forename: Fumi
authors.initials: F
authors.lastname: Takemoto
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Muto
authors.forename: Wako
authors.initials: W
authors.lastname: Yumura
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusano
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced*; D000284:Administration, Oral; D000368:Aged; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood / Q000139:chemically induced*; D010024:Osteoporosis / Q000188:drug therapy
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; C087958:YM 529; D003404:Creatinine