title: Engineering peripheral nerve repair.
abstract: Current approaches for treating peripheral nerve injury have resulted in promising, yet insufficient functional recovery compared to the clinical standard of care, autologous nerve grafts. In order to design a construct that can match the regenerative potential of the autograft, all facets of nerve tissue must be incorporated in a combinatorial therapy. Engineered biomaterial scaffolds in the future will have to promote enhanced regeneration and appropriate reinnervation by targeting the highly sensitive response of regenerating nerves to their surrounding microenvironment.
authors.affiliation: Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Marquardt
authors.forename: Shelly E
authors.initials: SE
authors.lastname: Sakiyama-Elbert
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D004558:Electric Stimulation; D048091:Guided Tissue Regeneration; D006801:Humans; D009416:Nerve Regeneration / Q000187:drug effects; D059348:Peripheral Nerve Injuries / Q000473:pathology / Q000628:therapy*; D010525:Peripheral Nerves / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials