title: Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction.
abstract: A series of functionalized spiro[indoline-3,2'-oxiran]-2-ones was efficiently synthesized by Darzens reaction of phenacyl bromides with isatins both with N-alkyl groups and without N-substituent in the presence of potassium carbonate as a base catalyst. When two equivalents phenacyl bromides were used in the reaction, the N-substitution reaction of isatin also finished with the formation of spiro-oxirane-oxindoles.
authors.affiliation: College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Fu
authors.forename: Chao-Guo
authors.initials: CG
authors.lastname: Yan
keywords: Darzens reaction; isatin; oxindole; oxirane; spiro-epoxyoxindole; spirooxindole