title: Osteomalacia induced by vitamin D deficiency in hemodialysis patients: the crucial role of vitamin D correction.
abstract: Vitamin D deficiency/insufficiency is significantly prevalent in chronic kidney disease. Data in the literature are however scarce about the effects of this deficiency on bone metabolism in hemodialysis (HD) patients. Moreover, it is still debated whether low vitamin D levels should be normalized in HD patients. In this paper, we report two cases showing the deleterious consequences of vitamin D deficiency in HD patients which is characterised by hypophosphatemia, hypocalcemia and osteomalacia (OM) leading to bone fractures. As vitamin D repletion is an easy way to treat OM, this report underlines the importance of monitoring and correction of vitamin D deficiency in this population.
authors.affiliation: Laboratoire de Biologie Intégrative du Tissu Osseux, INSERM-U1059, Université de Lyon, Saint-Etienne, France, fabrice.mac-way@mail.chuq.qc.ca.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Mac-Way
authors.forename: Linda
authors.initials: L
authors.lastname: Azzouz
authors.forename: Christian
authors.initials: C
authors.lastname: Noel
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Lafage-Proust
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D010018:Osteomalacia / Q000188:drug therapy / Q000209:etiology*; D006435:Renal Dialysis; D014807:Vitamin D / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy
chemical_list: D014807:Vitamin D