title: Predictors of mortality in patients with prosthetic valve infective endocarditis: a nation-wide multicenter study.
abstract: BACKGROUND
  Our aim was to investigate the clinical and prognostic features of the patients with prosthetic valve endocarditis (PVE) in a multicenter nation-wide study.
  
  
  METHODS
  The present nation-wide study consisted of 75 consecutive patients with PVE treated at 13 major hospitals in Turkey from 2005 to 2012.
  
  
  RESULTS
  The patients who died during follow-up were significantly older than the survivors and had higher C-reactive protein (CRP), creatinine, poor NYHA functional class and large vegetations. High creatinine level (odds ratio [OR] 2.6, 95% confidence interval [CI] 1.14-6.13), poor functional status (OR 24.5; 95% CI 3.1-196.5) and high CRP (OR 1.02; 95% CI1.00-1.03) measured on admission were independent risk associates for in-hospital mortality.
  
  
  CONCLUSIONS
  High creatinine level, poor functional status and high CRP measured on admission were independent risk associates for in-hospital mortality, whereas a NYHA class ofIII/IV and high CRP reflected independent risk for stroke/mortality end point.
authors.affiliation: Dicle University School of Medicine, Depar tment of Cardiology. Diyarbakir, Turkey. elbeymali@hotmail.com.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Elbey
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kalkan
authors.forename: Serkan
authors.initials: S
authors.lastname: Akdag
authors.forename: Kerem
authors.initials: K
authors.lastname: Ozbek
authors.forename: Nihan Kahya
authors.initials: NK
authors.lastname: Eren
authors.forename: Sinan
authors.initials: S
authors.lastname: Demirtas
authors.forename: Mehmet Ata
authors.initials: MA
authors.lastname: Akil
authors.forename: Selim
authors.initials: S
authors.lastname: Topcu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Oylumlu
authors.forename: Zihni
authors.initials: Z
authors.lastname: Bilik
authors.forename: Murat
authors.initials: M
authors.lastname: Yuksel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood; D004696:Endocarditis / Q000097:blood / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D006304:Health Status; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D016459:Prosthesis-Related Infections / Q000097:blood / Q000175:diagnosis / Q000401:mortality*; D012307:Risk Factors; D020521:Stroke / Q000401:mortality; D013997:Time Factors; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D003404:Creatinine