title: Alpha (1,2)-fucosyltransferase M307A polymorphism improves piglet survival.
abstract: To confirm the beneficial effects of alpha (1,2)-fucosyltransferase (FUT1) M307 (A) on piglet survival on commercial farms, we performed PCR-RFLP analysis of FUT1 M307 in successfully marketed (n = 245) and disease affected/deceased pigs during weaning (n = 252) at a commercial farm. We also evaluated the FUT1 genotypes of 190 healthy pigs from three different genetic backgrounds. The distribution of genotypes differed between the successfully marketed and disease affected/deceased pig groups. The frequency of the A allele, associated with resistance to edema and post-weaning diarrhea, was higher in the post-weaning survival group (0.21) than in the non-survival group (0.16, P < 0.05). The odds ratio for piglet survival between AA and GG genotypes was 1.98; thus, piglet survival for individuals with the AA genotype was almost two-fold greater than for GG individuals. The FUT1 gene polymorphism can be used as an effective marker for selection programs to improve post-weaning piglet survival.
authors.affiliation: Department of Animal Biotechnology, Konkuk University, Seoul, South Korea.
authors.forename: Kyungtae
authors.initials: K
authors.lastname: Kim
authors.forename: Dinh Truong
authors.initials: DT
authors.lastname: Nguyen
authors.forename: Minkyung
authors.initials: M
authors.lastname: Choi
authors.forename: Jin-Hoi
authors.initials: JH
authors.lastname: Kim
authors.forename: Han Geuk
authors.initials: HG
authors.lastname: Seo
authors.forename: Hailu
authors.initials: H
authors.lastname: Dadi
authors.forename: Se-Yeoun
authors.initials: SY
authors.lastname: Cha
authors.forename: Kunho
authors.initials: K
authors.lastname: Seo
authors.forename: Yun-Mi
authors.initials: YM
authors.lastname: Lee
authors.forename: Jong-Joo
authors.initials: JJ
authors.lastname: Kim
authors.forename: Chankyu
authors.initials: C
authors.lastname: Park
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005647:Fucosyltransferases / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D016019:Survival Analysis; D013552:Swine / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014886:Weaning; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D005647:Fucosyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase