title: Pharmacokinetics of vildagliptin in patients with varying degrees of renal impairment.
abstract: OBJECTIVE
  The kidney plays a key role in both the metabolism and excretion of vildagliptin. This study was designed to investigate the effects of varying degrees of renal impairment (RI) on the pharmacokinetics of vildagliptin.
  
  
  METHODS
  A total of 96 subjects were enrolled, and each subject received vildagliptin 50 mg dosed orally once daily for 14 days. Vildagliptin and metabolite concentrations in plasma and urine were measured on Days 1 and 14.
  
  
  RESULTS
  Compared to age-, gender-, BMI-matched subjects with normal renal function, the mean AUC of vildagliptin after 14 days in patients with mild, moderate, and severe RI increased by 40%, 71%, and 100%, respectively, and the Cmax of vildagliptin showed similar and minimal increases of 37%, 32% and 36%, respectively.
  
  
  CONCLUSIONS
  These pharmacokinetics results suggest that 50 mg once daily is an appropriate dose and recommended for patients with moderate and severe renal impairment.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: He
authors.forename: Kenneth
authors.initials: K
authors.lastname: Kulmatycki
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Christine
authors.initials: C
authors.lastname: Reynolds
authors.forename: Monica
authors.initials: M
authors.lastname: Ligueros-Saylan
authors.forename: Ann
authors.initials: A
authors.lastname: Taylor
mesh_terms: D000218:Adamantane / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015992:Body Mass Index; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects / Q000493:pharmacokinetics*; D011759:Pyrrolidines / Q000009:adverse effects / Q000493:pharmacokinetics*; D051437:Renal Insufficiency / Q000378:metabolism*; D000077597:Vildagliptin
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D009570:Nitriles; D011759:Pyrrolidines; D000077597:Vildagliptin; D000218:Adamantane