title: Uptake and retention of metallic nanoparticles in the Mediterranean mussel (Mytilus galloprovincialis).
abstract: We measured the uptake, distribution and elimination of two types of metallic nanoparticles (MetNPs) by the aquatic mussel Mytilus galloprovincialis in static seawater column exposures. Test MetNPs included polyethylene glycol (PEG) functionalized Fe3O4 nanoparticles (PEG-FeOxNP) and PEG-functionalized cadmium-selenide quantum dots (PEG-Qdot). Exposure water was sampled at various times to assess MetNP clearance, and mussels were serially euthanized to assess uptake of MetNPs into the hemolymph, digestive gland, and remaining carcass. Results indicated that >90% of both types of MetNPs were taken up by mussels within 8h of initial exposure. Nearly the entire retained dose of FeOxNPs and PEG-Qdots was deposited in the digestive gland. Our results provide important insights on the uptake and elimination kinetics of MetNPs in filter-feeding marine bivalves, and will be useful for subsequent development of toxicokinetic models to predict the kinetics of these processes.
authors.affiliation: Virginia Tech Department of Civil and Environmental Engineering, Blacksburg, VA, USA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Hull
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Vikesland
authors.forename: Irvin R
authors.initials: IR
authors.lastname: Schultz
mesh_terms: D000818:Animals; D004064:Digestive System / Q000737:chemistry; D053768:Metal Nanoparticles / Q000032:analysis; D049878:Mytilus / Q000378:metabolism*; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000378:metabolism*
chemical_list: D014874:Water Pollutants, Chemical
keywords: Body burden; Coastal waters; Iron oxide; Model-partitioning; Mytilus galloprovincialis; Nanoparticles; Quantum dot; Uptake and loss