title: Long-term quality of life and its predictive factors after oncologic surgery and microvascular reconstruction in patients with oral or oropharyngeal cancer.
abstract: The aims of this study were to evaluate long-term quality of life (QoL) and to determine its predictive factors after oncologic surgery and free flap reconstruction in patients with oral or oropharyngeal cancer. Patients treated at our institution between 2000 and 2009, who are alive and disease-free at least 1 year after therapy, completed the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire and the specific H&N35 module. Eighty patients were included in our study. Global QoL score was 69.3 ± 22.7%. Global QoL and general symptoms were correlated with T stage, whereas head and neck symptoms were correlated with T stage and tumor involvement of the tongue base. Emotional and social functioning scales, and resumption of professional activity were significantly associated with global QoL. In conclusion, T stage, tumor involvement of the tongue base, professional status and emotional and social functions were the main determinants of QoL in our study.
authors.affiliation: Department of Surgery, Institut Universitaire de la Face et du Cou, 31 Avenue de Valombrose, 06103, Nice, France.
authors.forename: Cédric S
authors.initials: CS
authors.lastname: Pierre
authors.forename: Olivier
authors.initials: O
authors.lastname: Dassonville
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Chamorey
authors.forename: Gilles
authors.initials: G
authors.lastname: Poissonnet
authors.forename: Marc
authors.initials: M
authors.lastname: Ettaiche
authors.forename: José
authors.initials: J
authors.lastname: Santini
authors.forename: Frédéric
authors.initials: F
authors.lastname: Peyrade
authors.forename: Karen
authors.initials: K
authors.lastname: Benezery
authors.forename: Anne
authors.initials: A
authors.lastname: Sudaka
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bozec
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000523:psychology / Q000601:surgery*; D005221:Fatigue; D005247:Feeding Behavior; D005260:Female; D006258:Head and Neck Neoplasms / Q000523:psychology / Q000601:surgery*; D006801:Humans; D008297:Male; D055806:Microvessels / Q000601:surgery*; D009062:Mouth Neoplasms / Q000523:psychology / Q000601:surgery*; D015999:Multivariate Analysis; D009959:Oropharyngeal Neoplasms / Q000523:psychology / Q000601:surgery*; D011788:Quality of Life / Q000523:psychology; D019651:Plastic Surgery Procedures; D058992:Social Participation; D000077195:Squamous Cell Carcinoma of Head and Neck; D013524:Surgical Flaps; D011795:Surveys and Questionnaires; D016896:Treatment Outcome