title: A scan statistic for binary outcome based on hypergeometric probability model, with an application to detecting spatial clusters of Japanese encephalitis.
abstract: As a useful tool for geographical cluster detection of events, the spatial scan statistic is widely applied in many fields and plays an increasingly important role. The classic version of the spatial scan statistic for the binary outcome is developed by Kulldorff, based on the Bernoulli or the Poisson probability model. In this paper, we apply the Hypergeometric probability model to construct the likelihood function under the null hypothesis. Compared with existing methods, the likelihood function under the null hypothesis is an alternative and indirect method to identify the potential cluster, and the test statistic is the extreme value of the likelihood function. Similar with Kulldorff's methods, we adopt Monte Carlo test for the test of significance. Both methods are applied for detecting spatial clusters of Japanese encephalitis in Sichuan province, China, in 2009, and the detected clusters are identical. Through a simulation to independent benchmark data, it is indicated that the test statistic based on the Hypergeometric model outweighs Kulldorff's statistics for clusters of high population density or large size; otherwise Kulldorff's statistics are superior.
authors.affiliation: Department of Biostatistics, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Zhou
authors.forename: Zijian
authors.initials: Z
authors.lastname: Feng
authors.forename: Pengfei
authors.initials: P
authors.lastname: Guo
authors.forename: Hongyan
authors.initials: H
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Duan
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Li
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D002681:China / Q000453:epidemiology; D003198:Computer Simulation; D004672:Encephalitis, Japanese / Q000453:epidemiology*; D006801:Humans; D016013:Likelihood Functions; D015233:Models, Statistical; D011336:Probability; D012306:Risk; D019371:Topography, Medical