title: Allergic contact dermatitis from octylisothiazolinone.
abstract: BACKGROUND
  Octylisothiazolinone is a biocide that has been reported as a moderate, but rare contact allergen.
  
  
  OBJECTIVE
  To investigate the occurrence of octylisothiazolinone contact allergy and allergic contact dermatitis diagnosed and registered in the Allergen Bank at Odense University Hospital during the past 20 years. Octylisothiazolinone has been used for targeted testing only.
  
  
  METHODS
  All octylisothiazolinone-patch test results registered in the Allergen Bank between January 1992 and February 2012 were analyzed.
  
  
  RESULTS
  A total of 20 out of 648 patients patch tested with octylisothiazolinone had positive reactions. The majority of the patients (90%) with relevant sensitizations to octylisothiazolinone had been exposed in occupational settings and most patients were painters.
  
  
  CONCLUSIONS
  Octylisothiazolinone is a relevant sensitizer.
authors.affiliation: Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense C, Denmark.
authors.forename: Anja P
authors.initials: AP
authors.lastname: Mose
authors.forename: Simon
authors.initials: S
authors.lastname: Frost
authors.forename: Ulf
authors.initials: U
authors.lastname: Ohlund
authors.forename: Klaus E
authors.initials: KE
authors.lastname: Andersen
mesh_terms: D000328:Adult; D015984:Causality; D003718:Denmark / Q000453:epidemiology; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D010150:Paint / Q000009:adverse effects*; D010328:Patch Tests / Q000706:statistics & numerical data; D012307:Risk Factors; D013844:Thiazoles / Q000008:administration & dosage / Q000009:adverse effects*; D017132:Workplace; D055815:Young Adult
chemical_list: D013844:Thiazoles; C512915:isothiazolidinone