title: Topical nicotinamide for seborrheic dermatitis: an open randomized study.
abstract: BACKGROUND
  Treatment of seborrheic dermatitis (SD) includes various options with different success and safety limitations.
  
  
  OBJECTIVE
  To evaluate the efficacy of topical nicotinamide (NCT) in the treatment of SD.
  
  
  METHODS
  A total of 48 patients with mild to moderate SD of the face were enrolled in the study (36 males and 12 females; age 20-50 years). Patients were randomized into two groups A and B, who were treated once a day with topical administration of NCT 4% cream and with the vehicle without NCT (placebo), respectively. Clinical measures were assessed by erythema, scaling, and infiltration, which were evaluated using a four-point scale 0-3 before starting treatment and after 2, 6, and 12 weeks' therapy.
  
  
  RESULTS
  In comparison with baseline, a reduction of 75% of the total score was observed in patients treated with NCT, whereas for placebo-treated patients the reduction was of 35% (p < 0.05).
  
  
  CONCLUSIONS
  Topical NCT 4% can have a potential for the treatment of SD.
authors.affiliation: Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II , Naples , Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Fabbrocini
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Cantelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Monfrecola
mesh_terms: D000287:Administration, Topical; D000328:Adult; D012628:Dermatitis, Seborrheic / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005145:Face; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000008:administration & dosage*; D063465:Skin Cream / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D009536:Niacinamide