title: Evaluation of TNF superfamily molecules in multiple myeloma patients: correlation with biological and clinical features.
abstract: B-cell activating factor (BAFF), a proliferation-inducing ligand (APRIL) and apoptosis inducing ligand (TRAIL) are members of the tumour necrosis factor (TNF) family. They are the main survival factors for immature, naive and activated B cells. We have analysed BAFF, APRIL and TRAIL serum concentrations in 52 patients with newly diagnosed IgG multiple myeloma and 20 healthy volunteers. The values were significantly higher in the studied patients and advanced diseases, decreasing after chemotherapy, compared to the control group. It was established that BAFF as APRIL (but not TRAIL) correlated with adverse prognostic factors such as IL-6 and lactate dehydrogenase. Furthermore, higher concentrations of APRIL and BAFF (but not TRAIL) predicted a shorter progression free survival, suggesting thereby an important prognostic marker and a possible therapeutic target in myeloma.
authors.affiliation: Department of Human Anatomy, Medical University of Bialystok, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Lemancewicz
authors.forename: Lukasz
authors.initials: L
authors.lastname: Bolkun
authors.forename: Ewa
authors.initials: E
authors.lastname: Jablonska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kulczynska
authors.forename: Urszula
authors.initials: U
authors.lastname: Bolkun-Skornicka
authors.forename: Janusz
authors.initials: J
authors.lastname: Kloczko
authors.forename: Janusz
authors.initials: J
authors.lastname: Dzieciol
mesh_terms: D000328:Adult; D000368:Aged; D053264:B-Cell Activating Factor / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy / Q000401:mortality*; D011379:Prognosis; D015996:Survival Rate; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000097:blood*; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000097:blood*
chemical_list: D053264:B-Cell Activating Factor; D014408:Biomarkers, Tumor; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; C505719:TNFSF13B protein, human; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13
keywords: APRIL; BAFF; Multiple myeloma; TRAIL