title: Neuroendocrine tumor in the liver of a patient with isolated polycystic liver disease: A case report and review of the literature.
abstract: Neuroendocrine tumors (NETs) frequently metastasize to the liver, but it is rare to find them there as primary tumors. Isolated polycystic liver disease (PCLD) is a rare autosomal dominant disease. There is no known association between polycystic liver disease and neuroendocrine or other tumors. We report a case of a 64-year-old female with a past medical history of isolated PCLD who presented with increasing abdominal pain over a two-week period. Our patient underwent open surgical biopsy one month after presentation. The histological examination and immunohistochemical findings suggested an intermediate grade neuroendocrine tumor. A 24-h delayed whole-body scintigraphy technique was utilized for the identification and localization of neuroendocrine tumors via the administration of In-111-labeled OctreoScan; however, no extrahepatic accumulation was observed. No previous studies in the literature describe a patient with PCLD and a primary or metastatic neuroendocrine tumor of the liver.
authors.affiliation: Department of Internal Medicine, General Hospital of Naoussa, Thessaloniki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Koutsampasopoulos
authors.forename: Elisavet
authors.initials: E
authors.lastname: Antoniadou
authors.forename: Stavros
authors.initials: S
authors.lastname: Zoutis
authors.forename: Grigorios
authors.initials: G
authors.lastname: Iacovidis
authors.forename: Olga
authors.initials: O
authors.lastname: Burova
authors.forename: Antonios
authors.initials: A
authors.lastname: Taplidis
keywords: neuroendocrine tumor; polycystic liver disease