title: Efficacy of lacosamide on seizures and myoclonus in a patient with epilepsia partialis continua.
abstract: A 39-year-old male with epilepsia partialis continua, refractory to first- and second-line antiepileptic drugs, is described. Lacosamide produced a progressive antiepileptic effect on Jacksonian motor seizures and subsequently on positive myoclonus, which developed into negative myoclonus before complete resolution. Our report confirms the efficacy of lacosamide on focal motor refractory status epilepticus and documents a unique effect of lacosamide on seizure semiology.
authors.affiliation: Unit of Clinical Neurophysiology, Azienda Ospedaliero-Universitaria, Florence, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Spalletti
authors.forename: Angela
authors.initials: A
authors.lastname: Comanducci
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vagaggini
authors.forename: Luca
authors.initials: L
authors.lastname: Bucciardini
authors.forename: Antonello
authors.initials: A
authors.lastname: Grippo
authors.forename: Aldo
authors.initials: A
authors.lastname: Amantini
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D017036:Epilepsia Partialis Continua / Q000188:drug therapy* / Q000209:etiology; D006408:Hematoma, Subdural / Q000150:complications; D006801:Humans; D000078334:Lacosamide; D008297:Male
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide
keywords: epilepsia partialis continua; lacosamide; myoclonus; negative myoclonus; refractory status epilepticus