title: Disentangling breast cancer patients' perceptions and experiences with regard to endocrine therapy: nature and relevance for non-adherence.
abstract: OBJECTIVE
  Adjuvant endocrine therapy effectively prevents recurrence and progression of estrogen-receptor positive breast cancer. However, studies reveal substantial non-adherence. The objective was therefore to identify the nature of the experiences and beliefs of women treated with endocrine therapy in an attempt to find potential determinants of non-adherence.
  
  
  METHODS
  Online Focus Groups (OFGs) and individual interviews were conducted with 37 women who were treated with endocrine therapy. Sixty-three statements derived from the OFGs and 11 belief items from the Beliefs about Medicines Questionnaire (BMQ) were used in a Q-sorting task conducted with 14 of the women. The quantitative Q-sorting data were statistically analyzed with Hierarchical Cluster Analysis.
  
  
  RESULTS
  A six cluster solution was revealed that included the clusters 'information', 'efficacy', 'tenacity', 'coping', 'side effects' and 'usage'. Women's own experiences and perceptions were not clearly delineated from the beliefs measured with the BMQ. However, women judged their own experiences and perceptions with regard to endocrine therapy as more relevant for adherence than the BMQ beliefs.
  
  
  CONCLUSIONS
  In order to understand and to improve women's adherence to endocrine therapy, women's own perceptions and experiences about endocrine therapy should be targeted in addition to common beliefs that apply to a wide range of medicines.
authors.affiliation: Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands. Electronic address: j.wouters@uu.nl.
authors.forename: Hans
authors.initials: H
authors.lastname: Wouters
authors.forename: Erica C G
authors.initials: EC
authors.lastname: van Geffen
authors.forename: Monique C
authors.initials: MC
authors.lastname: Baas-Thijssen
authors.forename: Elly M
authors.initials: EM
authors.lastname: Krol-Warmerdam
authors.forename: Anne M
authors.initials: AM
authors.lastname: Stiggelbout
authors.forename: Svetlana
authors.initials: S
authors.lastname: Belitser
authors.forename: Marcel L
authors.initials: ML
authors.lastname: Bouvy
authors.forename: Liset
authors.initials: L
authors.lastname: van Dijk
mesh_terms: D000328:Adult; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000523:psychology*; D017024:Chemotherapy, Adjuvant; D005260:Female; D017144:Focus Groups; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007407:Interviews as Topic; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D010465:Perception; D011795:Surveys and Questionnaires
chemical_list: D018931:Antineoplastic Agents, Hormonal
keywords: Adverse effects; Antineoplastic agents; Breast neoplasms; Patient adherence; Patient-centered care; Patient-preference; Therapeutic use