title: Teriparatide treatment of osteoporosis in a patient with anorexia nervosa.
abstract: Osteoporosis commonly occurs in patients with anorexia nervosa (AN) and is often irreversible even after weight restoration. We describe a 52-year-old woman with AN and severe osteoporosis, discovered after she sustained multiple fractures from a fall. She had low weight for most of her life, but was only formally diagnosed with AN 6 years prior to her presentation. She received therapy for her eating disorder and was able to restore weight, which led to a 4.1 % improvement in her bone density. We then treated her with teriparatide for 2 years, which lead to a further 21 % increase in bone density and she has had no recurrence of fractures. Since AN-associated osteoporosis is characterized by low bone formation, teriparatide may be a useful treatment option.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Iowa Carver College of Medicine, E 426 GH, 200 Hawkins Drive, Iowa City, IA, 52242, USA, Amal-rahhal@uiowa.edu.
authors.forename: Amal
authors.initials: A
authors.lastname: Shibli-Rahhal
authors.forename: Laurie
authors.initials: L
authors.lastname: McCormick
mesh_terms: D000856:Anorexia Nervosa / Q000150:complications*; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy*; D019379:Teriparatide / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D019379:Teriparatide