title: The effect of tranexamic acid on transfusion rate in primary total hip arthroplasty.
abstract: Total hip arthroplasty (THA) may produce blood loss requiring allogenic blood transfusion. Recently several authors have reported success decreasing their transfusion rate with tranexamic acid (TXA). We retrospectively reviewed our last 1595 primary THA in 1494 patients looking at whether the patients received TXA via IV infusion, topical application, or neither, and the need for a blood transfusion. Infusion of TXA acid produced a statistically significant difference in transfusion rate (p<0.001) while topical TXA failed to reach statistical significance (P=0.15). The transfusion rate without TXA was 19.86%, 4.39% with TXA infusion (odds ratio=5.36), and 12.86% (odds ratio=1.67) with topical TXA.
authors.affiliation: Carilion Clinic Orthopaedics, Roanoke, Virginia.
authors.forename: Tyler C
authors.initials: TC
authors.lastname: Wind
authors.affiliation: Medical University of South Carolina Department of Orthopaedic Surgery, Charleston, South Carolina; Human and Health Performance; College of Charleston, Charleston, South Carolina.
authors.forename: William R
authors.initials: WR
authors.lastname: Barfield
authors.affiliation: Carilion Clinic Orthopaedics, Roanoke, Virginia.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Moskal
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: antifibrinolytics; blood loss; total hip arthroplasty; tranexamic acid; transfusion rate