title: Roux-en-Y gastric bypass vs sleeve gastrectomy for obese patients with type 2 diabetes: a randomised trial.
abstract: OBJECTIVE
  Bariatric surgery is gaining acceptance as a 'metabolic surgical intervention' for patients with type 2 diabetes. The optimal form of surgery and the mechanism of action of these procedures are much debated. We compared two bariatric procedures for obese patients with type 2 diabetes and evaluated their effects on HbA1c and glucose tolerance.
  
  
  METHODS
  We performed a parallel un-blinded randomised trial of Roux-en-Y gastric bypass (RYGB) vs sleeve gastrectomy (SG) in 41 obese patients with type 2 diabetes, who were bariatric surgery candidates attending the obesity clinic. HbA1c, body composition and glucose tolerance were evaluated at baseline, and at 3 and 12 months.
  
  
  RESULTS
  Of the 41 patients, 37 completed the follow-up (19 RYGB, 18 SG). Both groups had similar baseline anthropometric and biochemical measures, and showed comparable weight loss and fat:fat-free mass ratio changes at 12 months. A similar normalisation of HbA1c levels was observed as early as 3 months post-surgery (6.37 ± 0.71% vs 6.23 ± 0.69% for RYGB vs SG respectively, p < 0.001 in both groups for baseline vs follow-up).
  
  
  CONCLUSIONS
  In this study, RYGB did not have a superior effect in comparison to SG with regard to HbA1c levels or weight loss during 12 months of follow-up.
  
  
  BACKGROUND
  ClinicalTrials.gov NCT00667706.
  
  
  BACKGROUND
  This work was supported by grant no. 3-000-8480 from the Israel Ministry of Health Chief Scientist, the Stephen Morse Diabetes Research Foundation and by Johnson & Johnson.
authors.affiliation: Department of Surgery, Bariatric Surgery Clinic, Rabin Medical Center, Petach Tikva, Israel.
authors.forename: Andrei
authors.initials: A
authors.lastname: Keidar
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Hershkop
authors.forename: Limor
authors.initials: L
authors.lastname: Marko
authors.forename: Chaya
authors.initials: C
authors.lastname: Schweiger
authors.forename: Lior
authors.initials: L
authors.lastname: Hecht
authors.forename: Noam
authors.initials: N
authors.lastname: Bartov
authors.forename: Assaf
authors.initials: A
authors.lastname: Kedar
authors.forename: Ram
authors.initials: R
authors.lastname: Weiss
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000601:surgery*; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D015390:Gastric Bypass / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000601:surgery*