title: Arthroscopic synovial biopsy in definitive diagnosis of joint diseases: An evaluation of efficacy and precision.
abstract: BACKGROUND
  Arthritis is an important cause of morbidity, presenting as monoarticular or polyarticular lesion. Arthroscopic synovial aspiration and biopsy can help in arriving specific etiological diagnosis.
  
  
  OBJECTIVE
  To evaluate the efficacy of arthroscopic synovial biopsy as a diagnostic aid and study the characteristics of synovial fluid in various joint diseases.
  
  
  METHODS
  Arthroscopic synovial biopsy along with synovial fluid analysis was studied in 30 of the 50 enrolled cases arthritis. The fluid was subjected to physical, biochemical, and cytological analysis.
  
  
  RESULTS
  Both rheumatoid (n = 14, 28%) and tubercular (n = 13, 26%) arthritis were found to be more common compared to other etiologies. Next common etiology observed was chronic nonspecific synovitis (n = 10, 20%). Clinicopathological correlation was seen in 34 out of 50 cases. As a diagnostic tool, synovial biopsy had a sensitivity of 85%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 62%.
  
  
  CONCLUSIONS
  Arthroscopic synovial biopsy is a simple and easy to perform technique and is an important useful investigative adjunct that may give conclusive diagnosis where clinical diagnosis is equivocal.
authors.affiliation: Department of Pathology, Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh, India.
authors.forename: Onis
authors.initials: O
authors.lastname: Singhal
authors.forename: Viplesh
authors.initials: V
authors.lastname: Kaur
authors.forename: Shivani
authors.initials: S
authors.lastname: Kalhan
authors.forename: Manish Kumar
authors.initials: MK
authors.lastname: Singhal
authors.forename: Anshu
authors.initials: A
authors.lastname: Gupta
authors.forename: Yv
authors.initials: Y
authors.lastname: Machave
keywords: Arthroscopy; synovial biopsy; synovial fluid analysis