title: How much do we know about drug handling by SLC and ABC drug transporters in children?
abstract: Although solute carrier (SLC) and ATP-binding cassette (ABC) transporters are critical to the absorption, distribution, and elimination of many small-molecule drugs in children, how these transporters regulate pediatric drug handling remains unclear. For proper dosing and to diminish toxicity, we need a better understanding of how organ development and functional maturation, as well as developmental changes in systemic physiology, impact transporter-mediated drug handling at pediatric developmental stages from the preterm infant through adolescence.
authors.affiliation: Department of Pediatrics, University of California-San Diego, La Jolla, California, USA. snigam@ucsd.edu
authors.forename: S K
authors.initials: SK
authors.lastname: Nigam
authors.forename: V
authors.initials: V
authors.lastname: Bhatnagar
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000502:physiology*; D000293:Adolescent; D000367:Age Factors; D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D026901:Membrane Transport Proteins / Q000502:physiology*; D023421:Models, Animal; D051381:Rats
chemical_list: D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D026901:Membrane Transport Proteins