title: Cellular fatty acid metabolism and cancer.
abstract: Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.
authors.affiliation: Department of Biochemistry & Biophysics, University of California, San Francisco, 94158, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Currie
authors.forename: Almut
authors.initials: A
authors.lastname: Schulze
authors.forename: Rudolf
authors.initials: R
authors.lastname: Zechner
authors.forename: Tobias C
authors.initials: TC
authors.lastname: Walther
authors.forename: Robert V
authors.initials: RV
authors.lastname: Farese
mesh_terms: D049109:Cell Proliferation; D004734:Energy Metabolism; D005227:Fatty Acids / Q000096:biosynthesis* / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D005227:Fatty Acids