title: Risk of lung cancer associated with occupational exposure to mineral wools: updating knowledge from a french population-based case-control study, the ICARE study.
abstract: OBJECTIVE
  To assess the risk of lung cancer associated with exposure to mineral wools (MWs), while taking into account smoking, asbestos, and crystalline silica exposures.
  
  
  METHODS
  The analyses were restricted to men (1350 cases and 1912 controls). Lifelong occupational history was collected. MWs and asbestos exposures were assessed, using task-exposure matrices and silica exposure, a job-exposure matrix.
  
  
  RESULTS
  We observed consistent not-significant increased risks of lung cancer of the same order of magnitude among workers exposed to high levels of MWs (odds ratio, 1.4; 95% confidence interval: 0.9 to 2.2; for highest quartile of the Cumulative Exposure Index).
  
  
  CONCLUSIONS
  These results do not allow to draw firm conclusion about a carcinogenic effect of MWs on the lung, but they cannot exclude it. Given the high number of potentially exposed workers, it will be necessary to replicate them in a future further removed from the asbestos ban.
authors.affiliation: UMRS 1018, the Environmental Epidemiology of Cancer Team, the Inserm, CESP Centre for Research in Epidemiology and Population Health, Villejuif, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Guida
authors.forename: Sophie
authors.initials: S
authors.lastname: Paget-Bailly
authors.forename: Farida
authors.initials: F
authors.lastname: Lamkarkach
authors.forename: Oumar
authors.initials: O
authors.lastname: Gaye
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ducamp
authors.forename: Gwenn
authors.initials: G
authors.lastname: Menvielle
authors.forename: Alexandra
authors.initials: A
authors.lastname: Papadopoulos
authors.forename: Mireille
authors.initials: M
authors.lastname: Matrat
authors.forename: Joëlle
authors.initials: J
authors.lastname: Févotte
authors.forename: Sylvie
authors.initials: S
authors.lastname: Cénée
authors.forename: Diane
authors.initials: D
authors.lastname: Cyr
authors.forename: Annie
authors.initials: A
authors.lastname: Schmaus
authors.forename: Matthieu
authors.initials: M
authors.lastname: Carton
authors.forename: Loredana
authors.initials: L
authors.lastname: Radoï
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Lapôtre-Ledoux
authors.forename: Florence
authors.initials: F
authors.lastname: Molinié
authors.forename: Danièle
authors.initials: D
authors.lastname: Luce
authors.forename: Isabelle
authors.initials: I
authors.lastname: Stücker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D001194:Asbestos / Q000009:adverse effects; D017610:Calcium Compounds / Q000009:adverse effects*; D016022:Case-Control Studies; D005602:France; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D012307:Risk Factors; D017640:Silicates / Q000009:adverse effects*; D012822:Silicon Dioxide / Q000009:adverse effects; D012907:Smoking / Q000009:adverse effects; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D017610:Calcium Compounds; D017640:Silicates; D001194:Asbestos; D012822:Silicon Dioxide; C031293:calcium silicate