title: Protein engineering: Chemistry gets the assist.
abstract: Integration of chemistry-based approaches into enzyme engineering provides a versatile strategy for biocatalyst development with the potential for improved performance and new catalytic activities. Application of this strategy led to the development of a whole-cell catalyst capable of converting olefins into cyclopropanes, synthetic intermediates used in the synthesis of more functionalized cycloalkanes and acyclic compounds.
authors.forename: Bettina M
authors.initials: BM
authors.lastname: Nestl
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hauer
mesh_terms: D000475:Alkenes / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008697:Methane / Q000031:analogs & derivatives* / Q000378:metabolism; D012694:Serine / Q000378:metabolism*
chemical_list: D000475:Alkenes; C030011:carbene; D012694:Serine; D003577:Cytochrome P-450 Enzyme System; D008697:Methane