title: Oncoprotein metastasis: an expanded topography.
abstract: In this survey, the initial insights on the sub- and transcellular process of oncoprotein metastasis (OPM) are linked to recent observations and advances in related fields. The six proteins described here, i.e. insulin, osteopontin, interleukin-6, anterior gradient-2 protein, cellular apoptosis susceptibility protein and hepatoma-derived growth factor, as well as distinct peptide fragments thereof might henceforth serve as pivotal biomarkers for OPM in clinical chemistry, molecular morphology, pathology and oncology and, as a result, guide as potential targets future structure-based interventions in cancer treatment.
authors.affiliation: Molecular Concepts Research (MCR), Münster, Germany. ratura@gmx.net
authors.forename: Razvan T
authors.initials: RT
authors.lastname: Radulescu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D015513:Oncogene Proteins / Q000378:metabolism*; D053495:Osteopontin / Q000235:genetics / Q000378:metabolism; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D015513:Oncogene Proteins; C051610:hepatoma-derived growth factor; D053495:Osteopontin