title: Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil.
abstract: The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.
authors.affiliation: Universidade Luterana do Brasil, Canoas, RS, Brasil.
authors.forename: Camila
authors.initials: C
authors.lastname: Marx
authors.forename: Tatiana Schäffer
authors.initials: TS
authors.lastname: Gregianini
authors.forename: Fernanda Kieling Moreira
authors.initials: FK
authors.lastname: Lehmann
authors.forename: Vagner Ricardo
authors.initials: VR
authors.lastname: Lunge
authors.forename: Silvia de
authors.initials: Sd
authors.lastname: Carli
authors.forename: Bibiana Paula
authors.initials: BP
authors.lastname: Dambrós
authors.forename: Gabriela Luchiari
authors.initials: GL
authors.lastname: Tumioto
authors.forename: Claudete
authors.initials: C
authors.lastname: Seadi
authors.forename: André Salvador Kazantzi
authors.initials: AS
authors.lastname: Fonseca
authors.forename: Nilo
authors.initials: N
authors.lastname: Ikuta
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001938:Brazil; D024882:Drug Resistance, Viral / Q000235:genetics*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics*; D053139:Oseltamivir / Q000494:pharmacology*; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D053139:Oseltamivir; D009439:Neuraminidase