title: Estimation of the common risk difference in stratified paired binary data with homogeneous stratum effect.
abstract: McNemar's test is commonly used to test for the risk difference between two binary variables on matched pairs. For stratified paired binary data, recently a test for the homogeneous stratum effect (HSE) has been developed. If HSE is rejected, then McNemar's test should be applied by stratum; otherwise, in this article we propose a concept of common risk difference (CRD) across the strata and derive point estimators and confidence intervals for CRD. We use a cancer study for illustration and conduct simulations to recommend point estimators and associated confidence intervals with good statistical properties.
authors.affiliation: Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Daniel-Zhao@ouhsc.edu
authors.forename: Yan D
authors.initials: YD
authors.lastname: Zhao
authors.forename: Dewi
authors.initials: D
authors.lastname: Rahardja
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D003198:Computer Simulation; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D016555:Matched-Pair Analysis; D015233:Models, Statistical; D016017:Odds Ratio; D012107:Research Design / Q000706:statistics & numerical data
chemical_list: D015415:Biomarkers