title: Pharmacogenomics of Cytauxzoon felis cytochrome b: implications for atovaquone and azithromycin therapy in domestic cats with cytauxzoonosis.
abstract: Cytauxzoon felis, an emerging virulent protozoan parasite that infects domestic cats, is treated with atovaquone and azithromycin (A&A). Atovaquone targets parasite cytochrome b. We characterized the C. felis cytochrome b gene (cytb) in cats with cytauxzoonosis and found a cytb genotype that was associated with survival in A&A-treated cats.
authors.affiliation: North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Schreeg
authors.forename: Henry S
authors.initials: HS
authors.lastname: Marr
authors.forename: Jaime
authors.initials: J
authors.lastname: Tarigo
authors.forename: Leah A
authors.initials: LA
authors.lastname: Cohn
authors.forename: Michael G
authors.initials: MG
authors.lastname: Levy
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Birkenheuer
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D053626:Atovaquone / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017963:Azithromycin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy / Q000469:parasitology*; D002415:Cats; D045303:Cytochromes b / Q000235:genetics / Q000378:metabolism*; D010597:Pharmacogenetics; D016792:Piroplasmida / Q000235:genetics / Q000378:metabolism*; D011528:Protozoan Infections / Q000188:drug therapy / Q000469:parasitology*
chemical_list: D000890:Anti-Infective Agents; D017963:Azithromycin; D045303:Cytochromes b; D053626:Atovaquone