title: Decreased plasma adiponectin is associated with impaired left ventricular longitudinal systolic function in hypertensive patients: a two-dimensional speckle tracking study.
abstract: The influence of plasma adiponectin levels on myocardial contractile function has not been fully examined. We aimed to investigate the relationship between three-directional systolic function and plasma adiponectin levels in asymptomatic hypertensive patients using two- dimensional speckle-tracking echocardiography. The study population consisted of 78 patients with hypertension and 40 healthy controls. Longitudinal strain was significantly reduced in all patients, including those without LV hypertrophy (p=0.009). In multiple-regression analysis, plasma adiponectin levels (β=-0.273, p=0.008) and LV mass index (β=0.458, p<0.001) independently correlated with LV longitudinal strain. Decreased plasma adiponectin concentrations were associated with the progression of LV hypertrophy with impaired LV longitudinal systolic function.
authors.affiliation: Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital , Istanbul , Turkey .
authors.forename: Birol
authors.initials: B
authors.lastname: Özkan
authors.forename: Göksel
authors.initials: G
authors.lastname: Açar
authors.forename: Gökhan
authors.initials: G
authors.lastname: Alıcı
authors.forename: Elnur
authors.initials: E
authors.lastname: Alizade
authors.forename: Mehmet Mustafa
authors.initials: MM
authors.lastname: Tabakcı
authors.forename: Müslüm
authors.initials: M
authors.lastname: Sahin
authors.forename: Mehmet Vefik
authors.initials: MV
authors.lastname: Yazıcıoğlu
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ozkok
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Tanboğa
authors.forename: Cihan
authors.initials: C
authors.lastname: Coşkun
authors.forename: Ali Metin
authors.initials: AM
authors.lastname: Esen
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000172:deficiency; D000328:Adult; D016022:Case-Control Studies; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging*; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging* / Q000209:etiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin