title: The role of food for the formation and prevention of gastrointestinal lesions induced by aspirin in cats.
abstract: OBJECTIVE
  The effects of feeding conditions (fasted or fed) and dietary fiber (DF) in the diet on gastrointestinal (GI) damage induced by aspirin (ASA) were examined in cats.
  
  
  METHODS
  Plain ASA (P-ASA, 20 mg/kg) or one enteric-coated ASA tablet (EC-ASA, containing 100 mg ASA) was administered p.o. once daily for 3 or 7 days just after morning meal, 3 h after the evening meal, or in the morning without a morning meal (fasted). Several types of diet, dry food (DRY, DF: 2.8 %), canned food (CAN, DF: 0.4 %), and diets with added cellulose or pectin were provided twice daily.
  
  
  RESULTS
  P-ASA or EC-ASA administered just after feeding of DRY caused marked lesions in the GI tract, although EC-ASA did not produce any lesions in the stomach. GI damage was markedly decreased when ASA was administered 3 h after the evening meal. The induction of lesions by EC-ASA was markedly decreased in cats that ate CAN, but lesions were induced in cats fed CAN with added cellulose (6 %). The addition of pectin (6 %) to the DRY markedly decreased the induction of lesions by EC-ASA.
  
  
  CONCLUSIONS
  The results indicate that the induction of GI lesions by ASA was highly dependent on the feeding conditions and DF. To minimize the induction of GI damage, it would be better to take ASA 3 h after the evening meal, or after consuming diets that contain low amounts of insoluble DF and high amounts of soluble DF.
authors.affiliation: Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, 607-8414, Japan, h_satoh@mb.kyoto-phu.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Satoh
authors.forename: Kikuko
authors.initials: K
authors.lastname: Amagase
authors.forename: Koji
authors.initials: K
authors.lastname: Takeuchi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D002415:Cats; D002927:Cimetidine / Q000627:therapeutic use; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology; D004195:Disease Models, Animal; D004435:Eating / Q000502:physiology*; D005260:Female; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D008297:Male; D016595:Misoprostol / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control*; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013608:Tablets, Enteric-Coated
chemical_list: D004043:Dietary Fiber; D013608:Tablets, Enteric-Coated; D016595:Misoprostol; D002927:Cimetidine; D001241:Aspirin