title: The dynamics of haemostatic parameters in acute psychotic patients: a one-year prospective study.
abstract: BACKGROUND
  The primary goal of the present study was to replicate our previous finding of increased coagulation and thrombocytes activity in drug-naïve psychotic patients in comparison with healthy controls and ascertain whether the blood levels of thrombogenesis markers further increase over the course of a consecutive one-year antipsychotic treatment.
  
  
  METHODS
  We investigated the plasma levels of markers indicating activation of coagulation (D-dimers and Factor VIII) and platelets (soluble P-selectin, sP-selectin) in an antipsychotic-naive group of nineteen men and seventeen women with acute psychosis (age 28.1±8.0 years, body mass index 22.6±4.2), and thirty-seven healthy volunteers matched for age, gender and body mass index. In the patient group, we repeated these assessments after three months and again after one year of antipsychotic treatment.
  
  
  RESULTS
  D-dimers (median 0.38 versus 0.19 mg/l; p=0.00008), factor VIII (median 141.5% versus 110%; p=0.02) and sP-selectin (median 183.6 versus 112.4 ng/ml; p=0.00005) plasma levels were significantly increased in the group of patients with acute psychosis prior to treatment compared with healthy volunteers. The plasma levels of sP-selectin varied significantly (p=0.016) in the course of the one-year antipsychotic treatment, mainly between 3 and 6 months after start of therapy. The plasma levels of D-dimers and factor VIII did not change significantly, D-dimers remained elevated in contrast to the healthy controls.
  
  
  CONCLUSIONS
  Patients with acute psychosis had increased levels of markers of thrombogenesis in comparison to the healthy volunteers. The haemostatic parameters also remained elevated during the one-year antipsychotic treatment.
authors.affiliation: Department of Psychiatry, University Hospital Hradec Králové, Sokolska 581, 500 05 Hradec Králové, Czech Republic. masopjir@seznam.cz
authors.forename: Jiří
authors.initials: J
authors.lastname: Masopust
authors.forename: Radovan
authors.initials: R
authors.lastname: Malý
authors.forename: Ctirad
authors.initials: C
authors.lastname: Andrýs
authors.forename: Martin
authors.initials: M
authors.lastname: Vališ
authors.forename: Jan
authors.initials: J
authors.lastname: Bažant
authors.forename: Ladislav
authors.initials: L
authors.lastname: Hosák
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000166:cytology; D005260:Female; D006801:Humans; D008297:Male; D019007:P-Selectin / Q000097:blood; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood*; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019007:P-Selectin