title: Incidence of tuberculosis in deceased-organ donors and transmission risk to recipients in Spain.
abstract: BACKGROUND
  Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients.
  
  
  METHODS
  Retrospective cohort study, including all actual deceased donors in Spanish hospitals between January 1998 and June 2011 and all the recipients who had received an organ from donors identified as TB cases.
  
  
  RESULTS
  Six actual donors were identified as TB cases, representing an annual incidence of 30.6 cases/100,000 donors (95% CI, 4-58). Two cases did not become utilized donors, because TB was detected in the organ recovery and were therefore excluded. Annual incidence in utilized donors was 23 cases/100,000 donors (95% CI, 6-59). Annual incidence of the Spanish population in the same period was 17.5 cases/100,000 inhabitants (95% CI, 17-18). Annual incidence in actual donors belonging to the Romanian immigrant community was 2353 cases/100,000 donors (95% CI, 286-8242). Variations in the prophylactic strategy utilized in recipients were observed. TB was transmitted to three recipients (27.3% transmission), two of whom developed active TB.
  
  
  CONCLUSIONS
  Incidence of TB in actual donors is greater than that of the general population (P < 0.001). The risk of immigrant communities should be grouped according to the real incidence in donors. Transmissibility of TB is high; therefore, transplant teams should be immediately informed when TB donor transmission is suspected to prevent TB in the recipient.
authors.affiliation: Organización Nacional de Trasplantes (ONT), Ministerio de Sanidad, Servicios Sociales e Igualdad (MSSSI), Madrid, Spain. ecoll@msssi.es
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Coll
authors.forename: Julián
authors.initials: J
authors.lastname: Torre-Cisneros
authors.forename: Rubén
authors.initials: R
authors.lastname: Calvo
authors.forename: Gregorio
authors.initials: G
authors.lastname: Garrido
authors.forename: Rafael
authors.initials: R
authors.lastname: Matesanz
mesh_terms: D000328:Adult; D002102:Cadaver; D002675:Child, Preschool; D015331:Cohort Studies; D054242:Emigrants and Immigrants; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012383:Romania / Q000208:ethnology; D013030:Spain / Q000453:epidemiology; D014019:Tissue Donors; D014376:Tuberculosis / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission*