title: Radiologic-pathologic correlation of renal cell carcinoma associated with Xp11.2 translocation.
abstract: BACKGROUND
  The prognosis of translocation RCCs in adult patients is relatively poor compared to that of other subtypes of RCCs. Although there have been several reports regarding radiologic findings of translocation RCC, studies with histologic correlation could help to understand the imaging features.
  
  
  OBJECTIVE
  To explore the correlation between radiologic and pathologic findings in Xp11.2 translocation renal cell carcinoma (RCC) and provide clues for translocation RCC diagnosis.
  
  
  METHODS
  CT scans of six patients (one man and five women; age range, 8-71 years; mean age, 34 years) with histologically-proven Xp11.2 translocation RCCs were retrospectively evaluated in consensus by two radiologists. Tumor size, presence of necrosis, hemorrhage, fat or calcification, enhancement patterns of the tumor, presence of lymphadenopathy, and distant metastases were evaluated.
  
  
  RESULTS
  The average size of the tumors was 6 cm (range, 2.7-12 cm). All six tumors appeared as well-defined masses with areas of low attenuation representing hemorrhage or necrosis. Four tumors contained high attenuating solid portions, compared to the surrounding renal cortex seen on unenhanced images, where representing dense cellular component on microscopic examination. Peripheral rim enhancement pattern that correlated with histologic finding of a fibrous capsule was seen in five cases. In two patients who underwent kidney MR, the masses showed low signal intensity on T2-weighted images. One patient had lymphadenopathy. No distant metastasis was noted in any patient.
  
  
  CONCLUSIONS
  Translocation RCC appeared as a well-defined mass that contain high attenuating solid portions on unenhanced images and low attenuating necrotic or hemorrhagic foci; the tumor also showed gradual peripheral rim enhancement due to a fibrous capsule surrounding the tumor.
authors.affiliation: Department of Radiology and Research, Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Koo
authors.forename: Hyuck Jae
authors.initials: HJ
authors.lastname: Choi
authors.forename: Mi-hyun
authors.initials: MH
authors.lastname: Kim
authors.forename: Kyoung-Sik
authors.initials: KS
authors.lastname: Cho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D002648:Child; D003287:Contrast Media; D005260:Female; D006470:Hemorrhage / Q000000981:diagnostic imaging; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011859:Radiography; D012189:Retrospective Studies; D014178:Translocation, Genetic
chemical_list: D003287:Contrast Media
keywords: CT findings; Renal cell carcinoma; computed tomography; radiologic findings; translocation renal cell carcinoma