title: The efficacy and safety of Simvastatin in the treatment of lipid abnormalities in diabetes mellitus.
abstract: BACKGROUND
  Notable lipid abnormalities in DM include elevated LDL-C which have been reported to be the prevalent lipid abnormality in DM and elevated total cholesterol levels. Although the Statins are widely used in the management of lipid abnormalities, their effects on the lipid abnormalities in Nigerians with DM has not been extensively evaluated.
  
  
  OBJECTIVE
  This report sets out to determine the effect of Simvor, a brand of Simvastatin in Nigerians with DM and abnormal lipid profiles.
  
  
  METHODS
  A total of 300 diabetic patients with abnormal lipid profile who were treatment naοve for lipid disorders were longitudinally recruited for the study. They were managed with Simvastatin (Simvor) in doses ranging from 20-40 mg alongside dietary counseling and exercise recommendation.
  
  
  RESULTS
  The mean age (SD) of the study subjects was 58.4 (10 years). The male; female ratio was 99:211. The proportions of lipid abnormalities for LDL-C, TCHOL, HDL-C and TG were 87%, 45%, 53% and 7% respectively. Following Simvastatin (Simvor) treatment, the mean LDL-C value was reduced by 16%, TCHOL by 23%, TG by 6% and HDL-C increased by 10%. Simvastatin (Simvor) was generally well tolerated and no cardiovascular events were noted in the study subjects during the period of the study.
  
  
  CONCLUSIONS
  Simvastatin (Simvor) was effective and well tolerated in the management of lipid disorders in Nigerians with DM.
authors.affiliation: Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.
authors.forename: Ogbera A
authors.initials: OA
authors.lastname: Okeoghene
authors.forename: Azenabor
authors.initials: A
authors.lastname: Alfred
keywords: Diabetes mellitus; lipid abnormalities; simvastatin