title: [Novel drugs provide better therapy for prostate cancer].
abstract: Several effective drugs have become available for prostate cancer therapy, which are being used after the development of castration resistance and studied already at an earlier stage of prostate cancer therapy. Novel hormonally acting drugs include degarelix, enzalutamide and abiraterone. Cytotoxic agents that have proven effective in studies include the docetaxel derivative cabazitaxel, denosumab in the prevention of complications caused by bone metastases, and radium-233 chloride as treatment for bone metastases. The optimal sequence of administration of the novel drugs as well as combining them are subject to intensive research.
authors.affiliation: Tampereen yliopisto, lääketieteen yksikköo ja TAYS.
authors.forename: Pirkko
authors.initials: P
authors.lastname: Kellokumpu-Lehtinen
authors.forename: Teuvo
authors.initials: T
authors.lastname: Tammela
mesh_terms: D000736:Androstenes; D000737:Androstenols / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D000069448:Denosumab; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D008297:Male; D009570:Nitriles; D009842:Oligopeptides / Q000627:therapeutic use; D010669:Phenylthiohydantoin / Q000031:analogs & derivatives / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011868:Radioisotopes / Q000627:therapeutic use; D011883:Radium / Q000627:therapeutic use; D043823:Taxoids / Q000627:therapeutic use
chemical_list: D000736:Androstenes; D000737:Androstenols; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D001549:Benzamides; D009570:Nitriles; D009842:Oligopeptides; D011868:Radioisotopes; D043823:Taxoids; C431566:acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide; D010669:Phenylthiohydantoin; D007987:Gonadotropin-Releasing Hormone; D000069448:Denosumab; C552428:cabazitaxel; C540278:enzalutamide; C089740:abiraterone; C581106:radium Ra 223 dichloride; D011883:Radium