title: Microbubbles from gas-generating perfluorohexane nanoemulsions for targeted temperature-sensitive ultrasonography and synergistic HIFU ablation of tumors.
abstract: A special "small to big" temperature-responsive phase-transformation strategy based on the "acoustic droplet vaporization (ADV)" mechanism is developed for efficient targeted ultrasonography and synergistic high intensity focused ultrasound (HIFU) cancer surgery by engineering targeted nanoemulsions, which is systematically evaluated and successfully demonstrated in vitro, ex vivo, and in vivo.
authors.affiliation: Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Hongxia
authors.initials: H
authors.lastname: Shen
authors.forename: Zhenchun
authors.initials: Z
authors.lastname: Luo
authors.forename: Ao
authors.initials: A
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Haitao
authors.initials: H
authors.lastname: Ran
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.forename: Weixiang
authors.initials: W
authors.lastname: Song
authors.forename: Zhu
authors.initials: Z
authors.lastname: Yang
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.forename: Zhibiao
authors.initials: Z
authors.lastname: Wang
authors.forename: Guangmin
authors.initials: G
authors.lastname: Lu
authors.forename: Yuanyi
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004655:Emulsions / Q000737:chemistry / Q000627:therapeutic use; D005466:Fluorocarbons / Q000138:chemical synthesis* / Q000627:therapeutic use*; D005740:Gases / Q000138:chemical synthesis / Q000627:therapeutic use; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D008422:Materials Testing; D051379:Mice; D008819:Mice, Nude; D045423:Microbubbles / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000628:therapy*; D013696:Temperature; D016896:Treatment Outcome
chemical_list: D004655:Emulsions; D005466:Fluorocarbons; D005740:Gases; C078626:perflexane
keywords: high intensity focused ultrasound (HIFU); nanotechnology; phase transformations; tumors; ultrasound imaging