title: Scaffolding proteins: not such innocent bystanders.
abstract: Sequential transfer of information from one enzyme to the next within the confines of a protein kinase scaffold enhances signal transduction. Though frequently considered to be inert organizational elements, two recent reports implicate kinase-scaffolding proteins as active participants in signal relay.
authors.affiliation: Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. smithdon@uw.edu
authors.forename: F Donelson
authors.initials: FD
authors.lastname: Smith
authors.forename: John D
authors.initials: JD
authors.lastname: Scott
mesh_terms: D000818:Animals; D060466:Axin Protein / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D060488:Low Density Lipoprotein Receptor-Related Protein-6 / Q000378:metabolism*; D008938:Mitosis; D010750:Phosphoproteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*; D012359:tRNA Methyltransferases / Q000378:metabolism*
chemical_list: D060466:Axin Protein; D018797:Cell Cycle Proteins; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D010750:Phosphoproteins; D029701:Saccharomyces cerevisiae Proteins; D051153:Wnt Proteins; D051176:beta Catenin; D012359:tRNA Methyltransferases; D017346:Protein Serine-Threonine Kinases; D003851:Deoxyribonucleases; D019204:GTP-Binding Proteins