title: TNFRSF11B polymorphisms are associated with metabolic traits in Uyghur and Han ethnic groups.
abstract: Abstract Introduction: To test whether genetic variants of osteoprotegerin gene (TNFRSF11B) affect metabolic traits (body mass index [BMI], glucose, triglyceride, total cholesterol) and bone mass traits.
  
  
  METHODS
  We conducted a population based association study to investigate associations of eight tagging single nucleotide polymorphisms (tSNPs) of the TNFRSF11B gene with the aforementioned traits in a Chinese Han population and an ethnic group admixed with Caucasians and Asians - Uyghur. The associations between the tSNPs and bone mass density (BMD) were also tested in Han population.
  
  
  RESULTS
  We found that SNP rs3102727, located in the first intron of the TNFRSF11B gene, was significantly associated with triglyceride levels in Uyghur population and Han population simultaneously. T allele of the rs3102727 variant was associated with a 0.10 mmol/L and 0.09 mmol/L lower level of triglyceride than C allele in Uyghur (p = 0.019) and Han subjects (p = 0.037), respectively. In addition, the T allele is also associated with a lower level of hip BMD (p = 0.025) and total BMD (p = 0.048). Further, we found significant associations between SNP rs11573869 and BMI in Uyghur subjects and SNP rs3134062 with hip BMD in Han sbujects. Rs11573869-T allele was associated with a 0.81 kg/m(2) lower level of BMI than C allele (p = 0.002) and the hip BMD decreases with the copy of rs3134062-T allele increases (p = 0.002).
  
  
  CONCLUSIONS
  We detected novel associations between TNFRSF11B polymorphisms and metabolic traits in Uyghur and Han populations. In addition, we found associations between TNFRSF11B polymorphisms and bone mass traits in Han population.
authors.affiliation: Key Laboratory for Basic Research in Cardiology, Ministry of Education, Tongji University School of Medicine , Shanghai , China .
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Cai
authors.forename: Hong-Bao
authors.initials: HB
authors.lastname: Wang
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Ren-Yong
authors.initials: RY
authors.lastname: Lin
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001786:Blood Glucose / Q000235:genetics*; D015992:Body Mass Index; D015519:Bone Density / Q000235:genetics*; D002681:China; D004734:Energy Metabolism / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D053244:Osteoprotegerin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human; D014280:Triglycerides