title: VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle.
abstract: Herein we report the design and synthesis of multifunctional VEGF-loaded IR800-conjugated graphene oxide (GO-IR800-VEGF) for multi-modality imaging-monitored therapeutic angiogenesis of ischemic muscle. The as-prepared GO-IR800-VEGF positively targets VEGF receptors, maintains an elevated level of VEGF in ischemic tissues for a prolonged time, and finally leads to remarkable therapeutic angiogenesis of ischemic muscle. Although more efforts are required to further understand the in vivo behaviors and the long-term toxicology of GO, our work demonstrates the success of using GO for efficient VEGF delivery in vivo by intravenous administration and suggests the great promise of using graphene oxide in theranostic applications for treating ischemic disease.
authors.affiliation: Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China 710032.
authors.forename: Zhongchan
authors.initials: Z
authors.lastname: Sun
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Guang
authors.initials: G
authors.lastname: Tong
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Albert
authors.initials: A
authors.lastname: Jin
authors.forename: Pengfei
authors.initials: P
authors.lastname: Rong
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.forename: Liming
authors.initials: L
authors.lastname: Nie
authors.forename: Gang
authors.initials: G
authors.lastname: Niu
authors.forename: Feng
authors.initials: F
authors.lastname: Cao
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology; D006614:Hindlimb / Q000098:blood supply* / Q000473:pathology; D007511:Ischemia / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D061848:Optical Imaging / Q000379:methods; D042461:Vascular Endothelial Growth Factor A / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003287:Contrast Media; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D006108:Graphite