title: [Expression and clinical significance of glycoprotein non-metastatic melanoma protein B in human renal cell carcinoma].
abstract: OBJECTIVE
  To investigate the role of glycoprotein non-metastatic melanoma protein B (GPNMB) in renal cell carcinoma (RCC).
  
  
  METHODS
  The method of immunohistochemistry (IHC) and Western blot were utilized to examine the expression of GPNMB in RCC and the normal adjacent tissues matched.
  
  
  RESULTS
  The expression of GPNMB was lower in RCC than in the matched normal adjacent tissues (P=0.022).
  
  
  CONCLUSIONS
  The abnormal expression of GPNMB may play an important role in the development of RCC and the detection of GPNMB may be useful for the early diagnosis of tumor and its development.
authors.affiliation: Department of Urology, Peking University People's Hospital, Beijing, China.
authors.forename: Cai-peng
authors.initials: CP
authors.lastname: Qin
authors.forename: Yun-bei
authors.initials: YB
authors.lastname: Xiao
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.forename: Ye-qing
authors.initials: YQ
authors.lastname: Yuan
authors.forename: Yi-chang
authors.initials: YC
authors.lastname: Hao
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
mesh_terms: D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C503042:GPNMB protein, human; D008562:Membrane Glycoproteins