title: Enantioselective cyclization of enamide-ynes and application to the synthesis of the kopsifoline core.
abstract: We report the palladium-catalyzed enantioselective cyclization of 1,6-enamidynes to form spirocyclic ring systems. We applied this methodology to the concise synthesis of the skeletal core of the kopsifoline alkaloids.
authors.affiliation: Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
authors.forename: Britton K
authors.initials: BK
authors.lastname: Corkey
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Heller
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Wang
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste
keywords: Palladium catalysis; electrophilic activation; enantioselective synthesis; natural product synthesis; spirocyclization