title: Treatment strategies for peripheral T-cell lymphomas.
abstract: Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of clinically aggressive diseases historically associated with inferior outcomes using conventional lymphoma therapies. Aggressive first line therapy and consolidation with autologous stem cell transplantation has led to improved survival, but the majority of patients either fails to respond to therapy or are not transplant candidates. Novel approaches have included new classes of drug and biological agents, including antifolates, immunoconjugates, histone deacetylase (HDAC) inhibitors, monoclonal antibodies, and signal transduction inhibitors. Molecular profiling has led to identification of relevant pathways for future novel approaches.
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA. francine.foss@yale.edu
authors.forename: Francine M
authors.initials: FM
authors.lastname: Foss
mesh_terms: D018943:Anthracyclines / Q000008:administration & dosage; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D002986:Clinical Trials as Topic; D005493:Folic Acid Antagonists / Q000008:administration & dosage; D056572:Histone Deacetylase Inhibitors / Q000008:administration & dosage; D006801:Humans; D018796:Immunoconjugates / Q000008:administration & dosage; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000473:pathology
chemical_list: D018943:Anthracyclines; D000911:Antibodies, Monoclonal; D005493:Folic Acid Antagonists; D056572:Histone Deacetylase Inhibitors; D018796:Immunoconjugates