title: Mechanical ventilation of mice under general anesthesia during experimental procedures.
abstract: Mechanical ventilation is frequently used in patients under general anesthesia during invasive procedures. Invasive animal experiments similarly require the maintenance of normal hemodynamic and pulmonary parameters during long-term general anesthesia. The authors describe a method for mechanical ventilation of mice. Mice were ventilated and monitored for up to 8 h of general anesthesia during surgery. Hemodynamic and pulmonary parameters remained within the normal ranges. The authors believe that this ventilation technique can be of great value for experimental procedures in mice that require general anesthesia.
authors.affiliation: Department of Anesthesiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. I.vandenBrink@anes.umcn.nl
authors.forename: Ilona
authors.initials: I
authors.lastname: van den Brink
authors.forename: Francien
authors.initials: F
authors.lastname: van de Pol
authors.forename: Michiel
authors.initials: M
authors.lastname: Vaneker
authors.forename: Matthijs
authors.initials: M
authors.lastname: Kox
authors.forename: Willem-Jan
authors.initials: WJ
authors.lastname: Schellekens
authors.forename: Merel
authors.initials: M
authors.lastname: Ritskes-Hoitinga
authors.forename: Gert Jan
authors.initials: GJ
authors.lastname: Scheffer
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D006439:Hemodynamics; D007431:Intraoperative Complications / Q000517:prevention & control / Q000662:veterinary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016343:Monitoring, Intraoperative / Q000662:veterinary; D012121:Respiration, Artificial / Q000662:veterinary*; D012129:Respiratory Function Tests; D013514:Surgical Procedures, Operative / Q000662:veterinary*