title: Evidence for efficient vertical transfer of maternal HIV-1 envelope-specific neutralizing antibodies but no association of such antibodies with reduced infant infection.
abstract: : Little is known about the efficiency of vertical transfer of HIV-1-specific antibodies. Antibody levels in plasma from 60 mother-infant pairs near the time of birth, including 14 breast-feeding transmission pairs, were compared. The envelope-binding titers were strongly correlated (r = 0.91, P < 0.0001) and similar (1.4-fold greater in maternal plasma) between a mother and her corresponding infant as were the neutralizing antibody (Nab) levels (r = 0.80, P < 0.0001; 1.3-fold higher), suggesting efficient transfer. There was no significant difference in Nab responses between transmitting and nontransmitting mothers, although there was a trend for transmitting mothers to have higher HIV-1-specific Nabs.
authors.affiliation: *Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA; †Program in Pathobiology, University of Washington, Seattle WA; ‡Department of Medicine, University of Washington, Seattle WA; §Department of Pediatrics, University of Nairobi, Nairobi, Kenya; ‖Division of Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA; Departments of ¶Biostatistics; #Global Health, University of Washington, Seattle, WA; and **Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
authors.forename: Maxwel M
authors.initials: MM
authors.lastname: Omenda
authors.forename: Caitlin
authors.initials: C
authors.lastname: Milligan
authors.forename: Katherine
authors.initials: K
authors.lastname: Odem-Davis
authors.forename: Ruth
authors.initials: R
authors.lastname: Nduati
authors.forename: Barbra A
authors.initials: BA
authors.lastname: Richardson
authors.forename: John
authors.initials: J
authors.lastname: Lynch
authors.forename: Grace
authors.initials: G
authors.lastname: John-Stewart
authors.forename: Julie
authors.initials: J
authors.lastname: Overbaugh
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood* / Q000276:immunology; D000918:Antibody Specificity; D001942:Breast Feeding / Q000009:adverse effects; D005260:Female; D015483:HIV Antibodies / Q000097:blood* / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D007630:Kenya; D009500:Neutralization Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000821:virology; D054299:env Gene Products, Human Immunodeficiency Virus / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D054299:env Gene Products, Human Immunodeficiency Virus