title: The role of consolidation treatment in locally advanced unresectable NSCLC.
abstract: Concurrent chemotherapy and radiation therapy remains the standard-of-care treatment in patients with unresectable stage III non-small-cell lung cancer. Most regimens include low doses of radiosensitizing agents. Because of concern for the presence of micrometastatic disease and the high rate of systemic failure, many trials have addressed the role of additional consolidation chemotherapy. Only a few of these studies have been performed in a randomized setting on a large number of patients, and the rest are smaller phase I and phase II trials that explore the safety and efficacy of different chemotherapy regimens. More recently, targeted agents have also been evaluated in such regimens, although molecular and histologic markers have not been fully incorporated in these studies. In this review, we discuss these trials and compare the different sequences and regimens of systemic doses of chemotherapy when delivered in addition to concurrent chemotherapy and radiation therapy.
authors.affiliation: Internal Medicine Department, Saint Elizabeth Health Center, 1044 Belmont Ave, Youngstown, OH 44501, USA.
authors.forename: Farhad
authors.initials: F
authors.lastname: Fakhrejahani
authors.forename: Nooshin
authors.initials: N
authors.lastname: Hashemi Sadraei
authors.forename: Tarek
authors.initials: T
authors.lastname: Mekhail
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D060830:Consolidation Chemotherapy / Q000379:methods*; D057915:Drug Substitution; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D018365:Neoplasm, Residual / Q000188:drug therapy; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents