title: Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl₂ and H₂O₂-induced SH-SY5Y cell injuries.
abstract: Three new alkaloids, 2α-hydroxy-6-O-n-butyloduline, O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine (1-3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-2'-methylbenzene-3',6'-diol (14), along with ten known alkaloids (4-13), were isolated from the bulbs of Lycoris aurea collected from Huaihua County of Hunan Province, China. Their structures were elucidated by spectroscopic methods including HRESIMS, UV, IR, and NMR. All the isolated compounds were tested for their neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell death. Compounds 1-7 and 10 exhibited significant neuroprotective effects against CoCl2-induced SH-SY5Y cell injury, while compounds 1-5, 7, 10 and 12 showed obvious neuroprotective effects against H2O2-induced SH-SY5Y cell death.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmacy, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, People's Republic of China.
authors.forename: An
authors.initials: A
authors.lastname: Jin
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Yun-Yun
authors.initials: YY
authors.lastname: Zhu
authors.forename: Heng-Yi
authors.initials: HY
authors.lastname: Yu
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Pi
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Han-Li
authors.initials: HL
authors.lastname: Ruan
mesh_terms: D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D003035:Cobalt / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity*; D031426:Lycoris; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; D003035:Cobalt; D006861:Hydrogen Peroxide; C018021:cobaltous chloride