title: Cancer Stem Cells Activate STAT3 the EZ Way.
abstract: Activated STAT3 and increased expression of the histone methyltransferase EZH2 are independently associated with the most malignant subset of gliomas. In this issue of Cancer Cell, Kim and colleagues discover that EZH2 enhances STAT3 activation by trimethylating lysine180 in STAT3 and does so preferentially in glioma stem-like cells.
authors.affiliation: Brain Tumor Research Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94158, USA.
authors.forename: Shaun D
authors.initials: SD
authors.lastname: Fouse
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Costello
mesh_terms: D000818:Animals; D000071221:Enhancer of Zeste Homolog 2 Protein; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D063151:Polycomb Repressive Complex 2 / Q000502:physiology*; D050796:STAT3 Transcription Factor / Q000378:metabolism*
chemical_list: D050796:STAT3 Transcription Factor; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2