title: [Pharmacogenetic criteria of drug-resistant epilepsy].
abstract: Pharmacogenetics, allows to improve our understanding of the mechanisms of action of AEDs and causes drug-resistence epilepsy. We found an association between farmakorezestentnistyu patient with epilepsy and the presence of a CC allele polymorphisms S3534T (rs1045642), S 1236T (rs 1128503) gene ABCB1 that encodes P-glycoprotein (hereafter P - glycoprotein rs1045642, P - glycoprotein rs1128503) and TT allelic polymorphism rs3812718 gene SCN1A, encoding a voltage-dependent sodium channels.
authors.forename: M M
authors.initials: MM
authors.lastname: Oros
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D004351:Drug Resistance / Q000187:drug effects / Q000235:genetics*; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D062550:NAV1.1 Voltage-Gated Sodium Channel / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000927:Anticonvulsants; D062550:NAV1.1 Voltage-Gated Sodium Channel; C568242:SCN1A protein, human