title: Design expert supported mathematical optimization and predictability study of buccoadhesive pharmaceutical wafers of Loratadine.
abstract: OBJECTIVE
  The objective of this work encompasses the application of the response surface approach in the development of buccoadhesive pharmaceutical wafers of Loratadine (LOR).
  
  
  METHODS
  Experiments were performed according to a 3(2) factorial design to evaluate the effects of buccoadhesive polymer, sodium alginate (A), and lactose monohydrate as ingredient, of hydrophilic matrix former (B) on the bioadhesive force, disintegration time, percent (%) swelling index, and time taken for 70% drug release (t(70%)). The effect of the two independent variables on the response variables was studied by response surface plots and contour plots generated by the Design-Expert software. The desirability function was used to optimize the response variables.
  
  
  RESULTS
  The compatibility between LOR and the wafer excipients was confirmed by differential scanning calorimetry, FTIR spectroscopy, and X-ray diffraction (XRD) analysis. Bioadhesion force, measured with TAXT2i texture analyzer, showed that the wafers had a good bioadhesive property which could be advantageous for retaining the drug into the buccal cavity.
  
  
  CONCLUSIONS
  The observed responses taken were in agreement with the experimental values, and Loratadine wafers were produced with less experimental trials, and a patient compliant product was achieved with the concept of formulation by design.
authors.affiliation: Bengal College of Pharmaceutical Sciences and Research, West Bengal University of Technology, Durgapur, West Bengal, India. prithvirajchakraborty.pc@gmail.com
authors.forename: Prithviraj
authors.initials: P
authors.lastname: Chakraborty
authors.forename: Surajit
authors.initials: S
authors.lastname: Dey
authors.forename: Versha
authors.initials: V
authors.lastname: Parcha
authors.forename: Shiv Sankar
authors.initials: SS
authors.lastname: Bhattacharya
authors.forename: Amitava
authors.initials: A
authors.lastname: Ghosh
mesh_terms: D000269:Adhesives / Q000494:pharmacology*; D000278:Administration, Buccal; D000704:Analysis of Variance; D000818:Animals; D002152:Calorimetry, Differential Scanning; D002417:Cattle; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D005079:Excipients; D005240:Feasibility Studies; D066298:In Vitro Techniques; D017336:Loratadine / Q000008:administration & dosage* / Q000494:pharmacology*; D008962:Models, Theoretical; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D000269:Adhesives; D004304:Dosage Forms; D005079:Excipients; D017336:Loratadine