title: Prediction of octreotide efficacy by electrogastrography in the treatment of patients with esophageal variceal hemorrhage.
abstract: Our aim is to investigate the significance of electrogastrography in the treatment of esophageal variceal hemorrhage with octreotide. Electrogastrography was performed in patients with esophageal variceal hemorrhage before and during the treatment consisting of various doses of octreotide (25 ug h(-1) group and 50 ug h(-1) group). The dominant power of electrogastrography and its relationship with the hemostatic efficacy of octreotide treatment were evaluated. Dominant power of electrogastrography decreased significantly during treatment with octreotide (P < 0.05). The reduction in the amplitude of dominant power in the 50 ug h(-1) group was significantly larger than in the 25 ug h(-1) group (P < 0.05), and it was correlated with hemostatic efficacy of octreotide treatment. We conclude that octreotide treatment in patients with esophageal variceal hemorrhage can result in a significant decrease of dominant power, which correlates with the hemostatic efficacy of octreotide, so the change of dominant power could be used as a predictor of evaluating the treatment efficacy of octreotide in esophageal variceal hemorrhage patients.
authors.affiliation: Emergency department of Hunan Provincial People's Hospital, Hunan Normal University, No. 61, Jie Fang xi road, Changsha, Hunan province 410005, People's Republic of China.
authors.forename: Yixiong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhiliing
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Han
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yan
authors.initials: Y
authors.lastname: Cao
authors.forename: Xingwen
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D004566:Electrodes; D004932:Esophageal and Gastric Varices / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006470:Hemorrhage / Q000150:complications* / Q000188:drug therapy*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009213:Myography / Q000379:methods*; D015282:Octreotide / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015282:Octreotide