title: Thermo-responsive hollow silica microgels with controlled drug release properties.
abstract: Thermo-responsive hollow silica microgels (THSMGs) consisting of a hollow core, an intermediate silica supporting layer and a smart polymer gel corona were fabricated via organic-inorganic hybridization. Hollow silica particles and PNIPAAm microgels were successfully combined by utilizing the cross-linking reaction between 3-(trimethoxysilyl) propyl methacrylate (TMSPMA) and silanol groups on the silica surface, and then the copolymerization of TMSPMA and N-isopropylacrylamide (NIPAAm). The morphology and chemical composition were systematically examined by field emission scanning electron microscope (FESEM), transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDS) and the Brunauer-Emmett-Teller (BET) measurement. The thermo-responsive phase transition behavior was investigated by the determination of the lower critical solution temperature (LCST), and particle size measurement using dynamic light scattering. THSMGs remain porous even after the coverage of PNIPAAm gels, and also have obvious hydrophilic/hydrophobic transition property and good swelling/collapse capability in spite of the rigid silica layer. The results of in vitro cytotoxicity evaluation and Rhodamine B (RHB) release study demonstrated that THSMGs have good biocompatibility, and achieve a thermo-responsive controlled-release behavior. The prepared THSMGs show considerable potential for applications as targeted and ambient temperature responsive drug delivery system.
authors.affiliation: State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, People's Republic China; Graduate University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, People's Republic China.
authors.forename: Changling
authors.initials: C
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, People's Republic China; Graduate University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan 430062 People's Republic China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan 430062 People's Republic China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, People's Republic China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, People's Republic China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, People's Republic China; Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan 430062 People's Republic China. Electronic address: zguo@licp.cas.cn.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, People's Republic China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D002138:Calibration; D003692:Delayed-Action Preparations; D005782:Gels / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D057446:Hydrodynamics; D046529:Microscopy, Electron, Transmission; D012235:Rhodamines / Q000494:pharmacology; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D012996:Solutions; D013052:Spectrometry, X-Ray Emission; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D012235:Rhodamines; D012996:Solutions; D012822:Silicon Dioxide; C029773:rhodamine B
keywords: Controlled drug release; Hollow silica microgel; Porous structure; Rhodamine B; Thermo-responsive