title: Computed tomography enterography and 18F-FDG PET/CT features of primary signet ring cell carcinoma of the small bowel in a patient with Crohn's disease.
abstract: We report a case of a primary signet ring cell carcinoma (PSRCC) of the small bowel in a patient with long-standing Crohn's disease, describing computed tomography (CT)-enterography (CTE) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT features of this rare tumor. CTE demonstrated submucosal thickening of a long ileal segment with preserved mural stratification. PET/CT examination showed increased 18F-FDG uptake in the affected ileal loop, hypermetabolic abdominal and mediastinal lymphadenopathies, and multiple hypermetabolic bone lesions. Iliac crest osteo-medullary biopsy revealed bone marrow infiltration by "signet ring" cells with intestinal differentiation. Double-balloon enteroscopy was used to obtain biopsies that confirmed the ileal origin of the PSRCC.
authors.affiliation: Department of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy. francesco.paparo@galliera.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Paparo
authors.forename: Arnoldo
authors.initials: A
authors.lastname: Piccardo
authors.forename: Matteo
authors.initials: M
authors.lastname: Clavarezza
authors.forename: Riccardo
authors.initials: R
authors.lastname: Piccazzo
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Bacigalupo
authors.forename: Luca
authors.initials: L
authors.lastname: Cevasco
authors.forename: Eugenio
authors.initials: E
authors.lastname: Marinaro
authors.forename: Gian Andrea
authors.initials: GA
authors.lastname: Rollandi
mesh_terms: D001706:Biopsy; D018279:Carcinoma, Signet Ring Cell / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003424:Crohn Disease / Q000150:complications*; D047630:Depsipeptides; D019788:Fluorodeoxyglucose F18; D005670:Fusarium; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography / Q000379:methods; D014057:Tomography, X-Ray Computed
chemical_list: D047630:Depsipeptides; D019788:Fluorodeoxyglucose F18; C014001:fusafungin