title: Recent advances in the Willgerodt-Kindler reaction.
abstract: The Willgerodt-Kindler reaction has, in recent years, received limited attention and application in synthetic organic chemistry. With the advent of new technology such as microwave-assisted heating, several new, high-yielding, practical, and more environmentally friendly reaction protocols have been developed. This review aims to once again draw attention to this relatively underutilised process by highlighting the recent developments in the Willgerodt-Kindler reaction in the synthesis of (thio)amides, carboxylic acids, and heterocycles.
authors.affiliation: Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany. carsten.bolm@oc.rwth-aachen.de.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Priebbenow
authors.forename: Carsten
authors.initials: C
authors.lastname: Bolm
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D055772:Green Chemistry Technology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D013854:Thioamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D006571:Heterocyclic Compounds; D013854:Thioamides