title: Correlation between periostin and SNCG and esophageal cancer invasion, infiltration and apoptosis.
abstract: OBJECTIVE
  To investigate the correlation between periostin and SNCG and esophageal cancer invasion, infiltration and apoptosis.
  
  
  METHODS
  A total of 78 cases esophageal surgical resection specimens were collected, expression of periostin and SNCG in esophageal cancer were detected. Effect of periostin and SNCG in esophageal carcinoma invasion and infiltration was analyzed.
  
  
  RESULTS
  The upregulated rate of periostin had significant difference in esophageal cancer tissues (39.74%), adjacent tissues (17.86%) and normal tissues (0.00%); The positive expression rates of SNCG had significant difference in esophageal cancer tissues (61.54%), adjacent tissues (32.14%) and normal tissues (1.96%); The upregulated rate of periostin had a significant correlation with lymph node metastasis, adventitia invasion, TNM stage; The positive expression rates of SNCG had a significant correlation with differentiation degree, lymph node metastasis, adventitia invasion, TNM stage; Apoptosis index of the positive of expression of SNCG of esophageal cancer tissue (4.541±2.267) was significantly lower than that of the negative expression (7.316±2.582) (P<0.05).
  
  
  CONCLUSIONS
  SNCG may play an important role in invasion, infiltration and apoptosis of esophageal cancer and serve as target spots in the targeted therapy of esophageal cancer.
authors.affiliation: Department of Oncology Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Luo
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000378:metabolism*; D015854:Up-Regulation; D051845:gamma-Synuclein / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D009363:Neoplasm Proteins; C512835:POSTN protein, human; C104249:SNCG protein, human; D051845:gamma-Synuclein