title: Dynamic acquisition of FLT3 or RAS alterations drive a subset of patients with lower risk MDS to secondary AML.
authors.affiliation: 1] Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA [2] Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: E
authors.initials: E
authors.lastname: Jabbour
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Luthra
authors.forename: C
authors.initials: C
authors.lastname: Bueso-Ramos
authors.forename: K
authors.initials: K
authors.lastname: Patel
authors.forename: S
authors.initials: S
authors.lastname: Pierce
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Wei
authors.forename: N
authors.initials: N
authors.lastname: Daver
authors.forename: S
authors.initials: S
authors.lastname: Faderl
authors.forename: F
authors.initials: F
authors.lastname: Ravandi
authors.forename: Z
authors.initials: Z
authors.lastname: Estrov
authors.forename: J
authors.initials: J
authors.lastname: Cortes
authors.forename: H
authors.initials: H
authors.lastname: Kantarjian
authors.forename: G
authors.initials: G
authors.lastname: Garcia-Manero
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D020558:GTP Phosphohydrolases / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*; D018631:ras Proteins / Q000235:genetics*
chemical_list: C117307:KRAS protein, human; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3; D020558:GTP Phosphohydrolases; C579846:NRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins