title: Physiology and morphology of inverted pyramidal neurons in the rodent neocortex.
abstract: An increasing number of studies indicate that there exists greater diversity of cortical neurons than previously appreciated. In the present report, we use a combination of physiological and morphological methods to characterize cortical neurons in infragranular layers with apical dendrites pointing toward the white-matter compared to those neurons with apical dendrites pointing toward the pia in both mouse and rat neocortex. Several features of the dendritic morphology and intrinsic and synaptic physiology of these "inverted" neurons revealed numerous differences among this cell type between species. We also found differences between the different cell types within the same species. These data reveal that similar cell types in the rat and mouse may not always share similar physiological and morphological properties. These data are relevant to models of information processing through micro- and larger neocortical circuits and indicate that different cell types found within similar lamina can have different functional properties.
authors.affiliation: Neuropsychology Doctoral Subprogram, The Graduate Center, CUNY, 365 Fifth Avenue, New York, NY 10016, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Steger
authors.affiliation: Department of Psychology, Queens College, City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA; Department of Biomedical Science, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Ramos
authors.affiliation: Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
authors.forename: R
authors.initials: R
authors.lastname: Cao
authors.affiliation: Neuropsychology Doctoral Subprogram, The Graduate Center, CUNY, 365 Fifth Avenue, New York, NY 10016, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Neuropsychology Doctoral Subprogram, The Graduate Center, CUNY, 365 Fifth Avenue, New York, NY 10016, USA.
authors.forename: C-C
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Department of Psychology, Queens College, City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA.
authors.forename: J
authors.initials: J
authors.lastname: Dominici
authors.affiliation: Neuropsychology Doctoral Subprogram, The Graduate Center, CUNY, 365 Fifth Avenue, New York, NY 10016, USA; Department of Psychology, Queens College, City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA. Electronic address: joshua.brumberg@qc.cuny.edu.
authors.forename: J C
authors.initials: JC
authors.lastname: Brumberg
mesh_terms: D000818:Animals; D003712:Dendrites / Q000648:ultrastructure; D008564:Membrane Potentials; D051379:Mice; D017966:Pyramidal Cells / Q000166:cytology* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000166:cytology* / Q000502:physiology*
keywords: inverted neurons; neocortex; pyramidal neurons