title: EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies.
abstract: Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting antibodies depend on EGFR expression levels.
authors.affiliation: Division of Stem Cell Transplantation and Immunotherapy; 2nd Department of Medicine; Christian-Albrechts-University and University Hospital Schleswig-Holstein; Kiel, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Derer
authors.forename: Stefan
authors.initials: S
authors.lastname: Lohse
authors.forename: Thomas
authors.initials: T
authors.lastname: Valerius
keywords: antibody; epidermal growth factor receptor; expression levels