title: Mammary analogue secretory carcinoma: update on a new diagnosis of salivary gland malignancy.
abstract: OBJECTIVE
  To review the known histopathologic findings and clinical behavior of mammary analogue secretory carcinoma (MASC).
  
  
  METHODS
  PubMed.
  
  
  METHODS
  Literature search using the terms "Mammary analogue secretory carcinoma," "Mammary analog secretory carcinoma," and "MASC" to identify all relevant publications.
  
  
  RESULTS
  MASC is an unusual and rare malignant salivary gland tumor first described in 2010. It shares histologic, immunohistochemical, and genetic features with secretory carcinoma of the breast. The clinical behavior of MASC ranges from slowly growing tumors that infrequently recur after surgical resection to aggressive tumors that cause widespread metastasis and death. Many cases of MASC were discovered in archived cases previously classified as acinic cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma not otherwise specified.
  
  
  CONCLUSIONS
  MASC is a newly recognized variant of salivary gland malignancy. Further research is needed to better delineate its overall prevalence and to define an appropriate treatment algorithm for this new clinical entity.
authors.affiliation: Harvard Medical School, Boston, MA.
authors.forename: Roshan
authors.initials: R
authors.lastname: Sethi
authors.affiliation: Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary / Harvard Medical School, Boston, MA.
authors.forename: Elliott
authors.initials: E
authors.lastname: Kozin
authors.affiliation: Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary / Harvard Medical School, Boston, MA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Remenschneider
authors.affiliation: Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary / Harvard Medical School, Boston, MA.
authors.forename: Josh
authors.initials: J
authors.lastname: Meier
authors.affiliation: Harvard Medical School, Boston, MA.
authors.forename: Paul
authors.initials: P
authors.lastname: VanderLaan
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston, MA.
authors.forename: William
authors.initials: W
authors.lastname: Faquin
authors.affiliation: Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary / Harvard Medical School, Boston, MA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Deschler
authors.affiliation: Division of Otolaryngology, Beth Israel Medical Center, Boston, MA; Department of Pathology, Beth Israel Medical Center, Boston, MA.
authors.forename: Robert
authors.initials: R
authors.lastname: Frankenthaler
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology; D002277:Carcinoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery
keywords: Salivary gland carcinoma; head and neck surgery; mammary analogue secretory carcinoma; parotid malignancy