title: The role of epigenetics in malignant pleural mesothelioma.
abstract: Malignant pleural mesothelioma (MPM) is an almost invariably fatal cancer of the pleura due to asbestos exposure. Increasing evidence indicates that unresponsiveness to chemotherapy is due to epigenetic errors leading to inadequate gene expression in tumor cells. The availability of compounds that modulate epigenetic modifications, such as histone acetylation or DNA methylation, offers new prospects for treatment of MPM. Here, we review latest findings on epigenetics in mesothelioma and present novel strategies for promising epigenetic therapies.
authors.affiliation: Molecular and Cellular Epigenetics (GIGA-Cancer) and Molecular Biology (GxABT), University of Liège (ULg), Liège, Belgium.
authors.forename: Fabian
authors.initials: F
authors.lastname: Vandermeers
authors.affiliation: Molecular and Cellular Epigenetics (GIGA-Cancer) and Molecular Biology (GxABT), University of Liège (ULg), Liège, Belgium.
authors.forename: Sathya
authors.initials: S
authors.lastname: Neelature Sriramareddy
authors.affiliation: Molecular and Cellular Epigenetics (GIGA-Cancer) and Molecular Biology (GxABT), University of Liège (ULg), Liège, Belgium.
authors.forename: Chrisostome
authors.initials: C
authors.lastname: Costa
authors.affiliation: Molecular and Cellular Epigenetics (GIGA-Cancer) and Molecular Biology (GxABT), University of Liège (ULg), Liège, Belgium.
authors.forename: Roland
authors.initials: R
authors.lastname: Hubaux
authors.affiliation: Molecular and Cellular Epigenetics (GIGA-Cancer) and Molecular Biology (GxABT), University of Liège (ULg), Liège, Belgium.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Cosse
authors.affiliation: Molecular and Cellular Epigenetics (GIGA-Cancer) and Molecular Biology (GxABT), University of Liège (ULg), Liège, Belgium. Electronic address: luc.willems@ulg.ac.be.
authors.forename: Luc
authors.initials: L
authors.lastname: Willems
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002986:Clinical Trials as Topic; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors; D044127:Epigenesis, Genetic / Q000187:drug effects; D057890:Epigenomics; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics*; D008654:Mesothelioma / Q000188:drug therapy / Q000235:genetics*; D000086002:Mesothelioma, Malignant; D010997:Pleural Neoplasms / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D004248:DNA (Cytosine-5-)-Methyltransferases
keywords: DNA methylation; Epigenetics; Histone acetylation; Mesothelioma