title: Nagelamides X-Z, dimeric bromopyrrole alkaloids from a marine sponge Agelas sp.
abstract: Three new dimeric bromopyrrole alkaloids, nagelamides X-Z (1-3), were isolated from a marine sponge Agelas sp. Nagelamides X (1) and Y (2) possess a novel tricyclic skeleton consisting of spiro-bonded tetrahydrobenzaminoimidazole and aminoimidazolidine moieties. Nagelamide Z (3) is the first dimeric bromopyrrole alkaloid involving the C-8 position in dimerization. The structures of 1-3 were elucidated on the basis of spectroscopic data. Nagelamides X-Z (1-3) exhibited antimicrobial activity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Naonobu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Taishi
authors.initials: T
authors.lastname: Kusama
authors.forename: Azusa
authors.initials: A
authors.lastname: Takahashi-Nakaguchi
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D047230:Agelas / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D011758:Pyrroles; D013141:Spiro Compounds; C585253:nagelamide X; C585252:nagelamide Y; C585251:nagelamide Z