title: Acute respiratory muscle weakness and apnea in a critically ill patient induced by colistin neurotoxicity: key potential role of hemoadsorption elimination during continuous venovenous hemofiltration.
abstract: We describe a patient with severe New Delhi metallo-β-lactamase-1 Escherichia coli infection who developed convulsions rapidly followed by acute respiratory muscle weakness and apnea while receiving intravenous colistin. Toxic levels of colistin were rapidly removed by hemofiltration and, more specifically, by hemoadsorption.
authors.affiliation: Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Honore
authors.forename: Rita
authors.initials: R
authors.lastname: Jacobs
authors.forename: Stijn
authors.initials: S
authors.lastname: Lochy
authors.forename: Elisabeth
authors.initials: E
authors.lastname: De Waele
authors.forename: Viola
authors.initials: V
authors.lastname: Van Gorp
authors.forename: Jouke
authors.initials: J
authors.lastname: De Regt
authors.forename: Geert
authors.initials: G
authors.lastname: Martens
authors.forename: Olivier
authors.initials: O
authors.lastname: Joannes-Boyau
authors.forename: Willem
authors.initials: W
authors.lastname: Boer
authors.forename: Herbert D
authors.initials: HD
authors.lastname: Spapen
keywords: CRRT; CVVH; apnea; colistin; convulsions; hemoadsorption; hemofiltration; neuromuscular blockade; neurotoxicity