title: Rice varietal differences in bioactive bran components for inhibition of colorectal cancer cell growth.
abstract: Rice bran chemical profiles differ across rice varieties and have not yet been analysed for differential chemopreventive bioactivity. A diverse panel of seven rice bran varieties was analysed for growth inhibition of human colorectal cancer (CRC) cells. Inhibition varied from 0% to 99%, depending on the variety of bran used. Across varieties, total lipid content ranged 5-16%, individual fatty acids had 1.4- to 1.9-fold differences, vitamin E isoforms (α-, γ-, δ-tocotrienols, and tocopherols) showed 1.3- to 15.2-fold differences, and differences in γ-oryzanol and total phenolics ranged between 100-275ng/mg and 57-146ngGAE/mg, respectively. Spearman correlation analysis was used to identify bioactive compounds implicated in CRC cell growth inhibitory activity. Total phenolics and γ-tocotrienol were positively correlated with reduced CRC cell growth (p<0.05). Stoichiometric variation in rice bran components and differential effects on CRC viability merit further evaluation elucidate their role in dietary CRC chemoprevention.
authors.affiliation: Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery Fort Collins, CO 80523, United States.
authors.forename: Genevieve M
authors.initials: GM
authors.lastname: Forster
authors.forename: Komal
authors.initials: K
authors.lastname: Raina
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: Sushil
authors.initials: S
authors.lastname: Kumar
authors.forename: Rajesh
authors.initials: R
authors.lastname: Agarwal
authors.forename: Ming-Hsuan
authors.initials: MH
authors.lastname: Chen
authors.forename: John E
authors.initials: JE
authors.lastname: Bauer
authors.forename: Anna M
authors.initials: AM
authors.lastname: McClung
authors.forename: Elizabeth P
authors.initials: EP
authors.lastname: Ryan
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000503:physiopathology*; D004043:Dietary Fiber / Q000032:analysis / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D012275:Oryza / Q000737:chemistry* / Q000145:classification; D010636:Phenols / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D004043:Dietary Fiber; D006131:Growth Inhibitors; D010636:Phenols; D010936:Plant Extracts; D014810:Vitamin E; C082097:tocotrienol, delta