title: N-Terminal α-amino group modification of peptides by an oxime formation-exchange reaction sequence.
abstract: A site-specific and efficient method for N-terminal modification of peptides using oxone for selective oxidation of N-terminal α-amino groups of peptides to oximes followed by transoximation with O-substituted hydroxylamines has been developed.
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
authors.forename: Karen Ka-Yan
authors.initials: KK
authors.lastname: Kung
authors.forename: Kong-Fan
authors.initials: KF
authors.lastname: Wong
authors.forename: King-Chi
authors.initials: KC
authors.lastname: Leung
authors.forename: Man-Kin
authors.initials: MK
authors.lastname: Wong
mesh_terms: D019811:Hydroxylamine / Q000737:chemistry*; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*
chemical_list: D010091:Oximes; D010455:Peptides; D019811:Hydroxylamine