title: The first silicon(IV) phthalocyanine-nucleoside conjugates with high photodynamic activity.
abstract: A series of novel silicon(IV) phthalocyanines conjugated axially with different nucleoside moieties (uridine, 5-methyluridine, cytidine, and 5-N-cytidine derivatives) have been synthesized and evaluated for their photodynamic activities. The uridine-containing compound 1 exhibits the highest photocytotoxicity against HepG2 human hepatocarcinoma cells with an IC50 value as low as 6 nM, which can be attributed to its high cellular uptake and non-aggregated nature in the biological media. This compound shows high affinity toward the mitochondria of HepG2 cells and causes cell death mainly through apoptosis upon illumination. The result indicates that 1 is a highly promising photosensitizer for photodynamic therapy.
authors.affiliation: College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China.
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Shen
authors.forename: Bi-Yuan
authors.initials: BY
authors.lastname: Zheng
authors.forename: Xiu-Rong
authors.initials: XR
authors.lastname: Huang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Huang
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D056945:Hep G2 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000188:drug therapy; D009705:Nucleosides / Q000737:chemistry*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D012825:Silicon / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D007211:Indoles; D054833:Isoindoles; D009705:Nucleosides; D017319:Photosensitizing Agents; C013647:phthalocyanine; D012825:Silicon