title: A single acute dose of pinitol from a naturally-occurring food ingredient decreases hyperglycaemia and circulating insulin levels in healthy subjects.
abstract: A limited amount of research suggests that oral ingestion of pinitol (3-O-methyl-d-chiro-inositol) positively influences glucose tolerance in humans. This study assessed the effects of different doses of pinitol supplementation on glucose tolerance, insulin sensitivity and plasma pinitol concentrations. Thirty healthy subjects underwent two one-day trials in which they consumed a nutritive beverage (Fruit Up®) containing 2.5, 4.0 or 6.0g of pinitol and a corresponding placebo equivalent in both energy and carbohydrates. Blood samples were collected frequently over the 240-min test period. The pinitol-enriched beverage reduced serum glucose and insulin at 45 and 60min, but only at a dose of 6.0g. Plasma pinitol concentrations, maximum concentration and AUC increased according to the dose administered. The results show that a single dose of pinitol from a naturally-occurring food ingredient at the highest dose administered acutely influences indices of whole-body glucose tolerance and insulin sensitivity in healthy subjects.
authors.affiliation: Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain. hernandez_antmij@gva.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Hernández-Mijares
authors.forename: Celia
authors.initials: C
authors.lastname: Bañuls
authors.forename: Jose E
authors.initials: JE
authors.lastname: Peris
authors.forename: Nuria
authors.initials: N
authors.lastname: Monzó
authors.forename: Ana
authors.initials: A
authors.lastname: Jover
authors.forename: Lorena
authors.initials: L
authors.lastname: Bellod
authors.forename: Victor M
authors.initials: VM
authors.lastname: Victor
authors.forename: Milagros
authors.initials: M
authors.lastname: Rocha
mesh_terms: D000328:Adult; D001628:Beverages / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D015536:Down-Regulation; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000178:diet therapy* / Q000378:metabolism; D007294:Inositol / Q000031:analogs & derivatives* / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008297:Male
chemical_list: D001786:Blood Glucose; D007328:Insulin; C021730:pinitol; D007294:Inositol