title: Guarding against collateral damage during chromatin transactions.
abstract: Signal amplifications are vital for chromatin function, yet they also bear the risk of transforming into unrestrained, self-escalating, and potentially harmful responses. Examples of inbuilt limitations are emerging, revealing how chromatin transactions are confined within physiological boundaries.
authors.affiliation: Chromosome Stability and Dynamics Group, Department of Disease Biology, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark. matthias.altmeyer@cpr.ku.dk
authors.forename: Matthias
authors.initials: M
authors.lastname: Altmeyer
authors.forename: Jiri
authors.initials: J
authors.lastname: Lukas
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D002843:Chromatin / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D005786:Gene Expression Regulation; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin