title: Alterations in hippocampal network oscillations and theta-gamma coupling arise before Aβ overproduction in a mouse model of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by memory impairments. Brain oscillatory activity is critical for cognitive function and is altered in AD patients. Recent evidence suggests that accumulation of soluble amyloid-beta (Aβ) induces reorganization of hippocampal networks. However, whether fine changes in network activity might be present at very early stages, before Aβ overproduction, remains to be determined. We therefore assessed whether theta and gamma oscillations and their cross-frequency coupling, which are known to be essential for normal memory function, were precociously altered in the hippocampus. Electrophysiological field potential recordings were performed using complete hippocampal preparations in vitro from young transgenic CRND8 mice, a transgenic mouse model of AD. Our results indicate that a significant proportion of 1-month-old TgCRND8 mice showed robust alterations of theta-gamma cross-frequency coupling in the principal output region of the hippocampus, the subiculum. In addition we showed that, compared to controls, these mice expressed negligible levels of Aβ. Finally, these network alterations were not due to genetic factors as 15-day-old animals did not exhibit theta-gamma coupling alterations. Thus, initial alterations in hippocampal network activity arise before Aβ accumulation and may represent an early biomarker for AD.
authors.affiliation: Douglas Mental Health University Institute, McGill University, 6875 Lasalle blvd, Verdun, Montreal H4H1R3, QC, Canada.
authors.forename: Romain
authors.initials: R
authors.lastname: Goutagny
authors.forename: Ning
authors.initials: N
authors.lastname: Gu
authors.forename: Chelsea
authors.initials: C
authors.lastname: Cavanagh
authors.forename: Jesse
authors.initials: J
authors.lastname: Jackson
authors.forename: Jean-Guy
authors.initials: JG
authors.lastname: Chabot
authors.forename: Rémi
authors.initials: R
authors.lastname: Quirion
authors.forename: Slavica
authors.initials: S
authors.lastname: Krantic
authors.forename: Sylvain
authors.initials: S
authors.lastname: Williams
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers; D058256:Brain Waves / Q000502:physiology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000503:physiopathology*; D066298:In Vitro Techniques; D051379:Mice; D008822:Mice, Transgenic; D009415:Nerve Net; D013826:Theta Rhythm / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers