title: The effect of adrenaline on desflurane-induced prolonged QTc interval: a randomized double-blind trial.
abstract: OBJECTIVE
  We investigated the effect of adrenaline on desflurane-induced prolonged corrected QT (QTc) interval.
  
  
  METHODS
  Sixty-two adult patients scheduled for nasal surgery were included. Following intubation, packs soaked in physiological saline were used for Group C (control) and packs soaked in adrenaline (1/200,000, 5 ml) were used for Groups A1 and A2. Group A2 was given desflurane simultaneously with nasal packing; other groups were given desflurane following removal of the packs. QTc interval was evaluated at 9 periods, from prior to induction of anaesthesia to postoperative first hour.
  
  
  RESULTS
  QTc interval was significantly reduced in Groups A1 and A2 compared to Group C during packaging (p < 0.001, p < 0.05 respectively), while QTc interval gradually prolonged after desflurane administration (p < 0.05 in Groups C compared to Groups A1 and A2). Patients did not develop arrhythmia.
  
  
  CONCLUSIONS
  Our findings show that desflurane caused progressive prolongation of the QTc interval, and adrenaline shortened QTc interval only at application period of packs.
authors.affiliation: Department of Anaesthesiology and Reanimation, Firat University School of Medicine, Elazig, Turkey. abestas@firat.edu.tr
authors.forename: A
authors.initials: A
authors.lastname: Bestas
authors.forename: O
authors.initials: O
authors.lastname: Hanbeyoglu
authors.forename: E
authors.initials: E
authors.lastname: Keles
authors.forename: M K
authors.initials: MK
authors.lastname: Bayar
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D000077335:Desflurane; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane; D004837:Epinephrine