title: Cytotoxic impact of phenolics from Lamiaceae species on human breast cancer cells.
abstract: The aim of this study was to evaluate the cytotoxicity of dried aqueous extracts from Thymus serpyllum (ExTs), Thymus vulgaris (ExTv), Majorana hortensis (ExMh), and Mentha piperita (ExMp), and the phenolic compounds caffeic acid (CA), rosmarinic acid (RA), lithospermic acid (LA), luteolin-7-O-glucuronide (Lgr), luteolin-7-O-rutinoside (Lr), eriodictiol-7-O-rutinoside (Er), and arbutin (Ab), on two human breast cancer cell lines: Adriamycin-resistant MCF-7/Adr and wild-type MCF-7/wt. In the MTT assay, ExMh showed the highest cytotoxicity, especially against MCF-7/Adr, whereas ExMp was the least toxic; particularly against MCF-7/wt cells. RA and LA exhibited the strongest cytotoxicity against both MCF-7 cell lines, over 2-fold greater than CA and Lgr, around 3-fold greater than Er, and around 4- to 7-fold in comparison with Lr and Ab. Except for Lr and Ab, all other phytochemicals were more toxic against MCF-7/wt, and all extracts exhibited higher toxicity against MCF-7/Adr. It might be concluded that the tested phenolics exhibited more beneficial properties when they were applied in the form of extracts comprising their mixtures.
authors.affiliation: Wrocław Medical University, Department of Medical Biochemistry, Chałubińskiego 10, 50-368 Wrocław, Poland. izabela.berdowska@am.wroc.pl
authors.forename: Izabela
authors.initials: I
authors.lastname: Berdowska
authors.forename: Bogdan
authors.initials: B
authors.lastname: Zieliński
authors.forename: Izabela
authors.initials: I
authors.lastname: Fecka
authors.forename: Julita
authors.initials: J
authors.lastname: Kulbacka
authors.forename: Jolanta
authors.initials: J
authors.lastname: Saczko
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gamian
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D001943:Breast Neoplasms / Q000503:physiopathology*; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D061986:MCF-7 Cells; D010636:Phenols / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010636:Phenols; D010936:Plant Extracts