title: ¹H, ¹³C and ¹⁵N NMR assignments of a Drosophila Hedgehog autoprocessing domain.
abstract: The Hedgehog (Hh) signaling pathway plays important roles in embryonic growth and patterning in different organisms. Abnormal activity of the Hh signaling pathway has been associated to cancers, holoprosencephaly and autism spectrum disorders. The backbone and side chain resonance assignments of a Drosophila Hh autoprocessing domain have been determined based on triple-resonance experiments with the [(13)C, (15)N]-labeled and [(2)H, (13)C, (15)N])-labeled proteins.
authors.affiliation: Biochemistry and Biophysics Graduate Program, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Xie
authors.forename: Zhenming
authors.initials: Z
authors.lastname: Du
authors.forename: Brian
authors.initials: B
authors.lastname: Callahan
authors.forename: Marlene
authors.initials: M
authors.lastname: Belfort
authors.forename: Chunyu
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000737:chemistry*; D004331:Drosophila melanogaster; D053823:Hedgehog Proteins / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary
chemical_list: D029721:Drosophila Proteins; D053823:Hedgehog Proteins