title: Mitosis as an anti-cancer drug target.
abstract: Suppression of cell proliferation by targeting mitosis is one potential cancer intervention. A number of existing chemotherapy drugs disrupt mitosis by targeting microtubule dynamics. While efficacious, these drugs have limitations, i.e. neuropathy, unpredictability and development of resistance. In order to overcome these issues, a great deal of effort has been spent exploring novel mitotic targets including Polo-like kinase 1, Aurora kinases, Mps1, Cenp-E and KSP/Eg5. Here we summarize the latest developments in the discovery and clinical evaluation of new mitotic drug targets.
authors.affiliation: VTT Biotechnology for Health and Wellbeing, VTT Technical Research Centre of Finland, Itäinen Pitkäkatu 4C, Pharmacity Bldg, 4th Floor, P.O. Box 106, 20521, Turku, Finland.
authors.forename: Anna-Leena
authors.initials: AL
authors.lastname: Salmela
authors.forename: Marko J
authors.initials: MJ
authors.lastname: Kallio
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D064127:Aurora Kinases / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D006801:Humans; D016547:Kinesins / Q000378:metabolism; D008938:Mitosis / Q000187:drug effects / Q000235:genetics*; D058990:Molecular Targeted Therapy; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D000097869:Polo-Like Kinase 1
chemical_list: D016588:Anticarcinogenic Agents; D064127:Aurora Kinases; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D016547:Kinesins; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1; C470243:KIF11 protein, human; C068688:centromere protein E; C075840:TTK protein, human