title: Myeloid-derived suppressor cells as a novel target for the control of osteolytic bone disease.
abstract: Myeloid-derived suppressor cells (MDSC) from mice bearing bone metastases differentiate into functional osteoclasts in vitro and in vivo, through a signaling pathway that relies on nitric oxide. In addition, MDSC-targeting drugs have been shown to robustly inhibit osteolysis. Thus, MDSC stand out as novel osteoclast progenitors and hence as candidate targets for the control of osteolytic bone disease.
authors.affiliation: Department of Pathology; University of Alabama at Birmingham; Birmingham, AL USA.
authors.forename: Anandi
authors.initials: A
authors.lastname: Sawant
authors.forename: Selvarangan
authors.initials: S
authors.lastname: Ponnazhagan
keywords: bone metastasis; breast cancer; myeloid-derived suppressor cells; osteoclasts