title: Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity.
abstract: Micelles for mucosal immunity: A mucosal vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the vaccine system induces a high immune response both in the humoral and cellular immunity (see picture).
authors.affiliation: Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Young-Woock
authors.initials: YW
authors.lastname: Noh
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Hong
authors.forename: Sang-Mu
authors.initials: SM
authors.lastname: Shim
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Park
authors.forename: Hee Ho
authors.initials: HH
authors.lastname: Bae
authors.forename: Eun Kyoung
authors.initials: EK
authors.lastname: Ryu
authors.forename: Jung Hwan
authors.initials: JH
authors.lastname: Hwang
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Lee
authors.forename: Seong Hun
authors.initials: SH
authors.lastname: Cho
authors.forename: Moon-Hee
authors.initials: MH
authors.lastname: Sung
authors.forename: Haryoung
authors.initials: H
authors.lastname: Poo
authors.forename: Yong Taik
authors.initials: YT
authors.lastname: Lim
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D004337:Drug Carriers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D056724:Immunity, Humoral / Q000276:immunology; D018928:Immunity, Mucosal / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009093:Mucus / Q000187:drug effects / Q000276:immunology; D053758:Nanoparticles / Q000008:administration & dosage*; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D011108:Polymers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014611:Vaccination; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D004337:Drug Carriers; D011108:Polymers; D014612:Vaccines; C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid; D010047:Ovalbumin
keywords: antigen; mucosal immunity; mucus delivery; nanomicelles; nanoparticles