title: Overexpression of HLA-G Is positively associated with Kazakh esophageal squamous cell carcinoma in Xinjiang, China.
abstract: HLA-G is a class I HLA that has gained much attention due to its multiple functions in the immune system. More important, some studies found HLA-G may be detrimental in tumors and viral infections, and the detection of HLA-G expression might serve as a clinical marker in the prediction of clinical outcomes for certain types of carcinoma. We assessed the association between the development of Kazakh esophageal squamous cell carcinoma (ESCC) harboring high-risk HPV infection and the expression of HLA-G. The expression of HLA-G was detected by S-P immunohistochemical staining in 60 cases of Kazakh ESCC tissues and 40 cases of Kazakh tumor adjacent normal tissues. HPV16 infection in ESCC was detected by genotype-specific polymerase chain reaction. HPV16 infection rate in Kazakh ESCC was 35.0%, significantly higher than that of the infection rate of the adjacent normal tissues 15% (p<0.05, OR=3.051; 95% CI: 1.103-8.438). The expression of HLA-G in Kazakh ESCC was 75.0% (45/60), significantly higher than that of tumor adjacent normal tissues (17.5%; p<0.05); expression of HLA-G was slightly higher in HPV16-positive than HPV16-negative ESCC, but the difference was not statistically significant (p>0.05). The positive expression rate of HLA-G was closely related to depth of invasion and clinical stage (p<0.05 for all), but was not related to age, sex, tumor location, histologic grade, and nodal status (p>0.05 for all). Overexpression of HLA-G was a characteristic feature of Kazakh ESCC; HLA-G may be involved in Kazakh ESCC carcinogenesis and HPV infection.
authors.affiliation: Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases Ministry of Education, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Hu
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Yangzheng
authors.initials: Y
authors.lastname: Liu
authors.forename: Yunzhao
authors.initials: Y
authors.lastname: Chen
authors.forename: Chunxia
authors.initials: C
authors.lastname: Liu
authors.forename: Weihua
authors.initials: W
authors.lastname: Liang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.forename: Hong
authors.initials: H
authors.lastname: Zou
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Cui
authors.forename: Yan
authors.initials: Y
authors.lastname: Qi
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Feng
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000276:immunology* / Q000473:pathology; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000276:immunology* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D015870:Gene Expression; D059951:HLA-G Antigens / Q000096:biosynthesis* / Q000235:genetics; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology*; D016133:Polymerase Chain Reaction
chemical_list: D059951:HLA-G Antigens