title: Quantitative T2 mapping for detecting myocardial edema after reperfusion of myocardial infarction: validation and comparison with T2-weighted images.
abstract: This study evaluates the clinical usefulness of T2 mapping for the detection of myocardial edema in the re-perfused acute myocardial infarction (MI). Cardiac MRIs were reviewed in 20 patients who had acute MI after reperfusion therapy. The regional T2 values and T2-weighted image (T2WI) signal intensities (SI) were measured in the infarcted and remote zones of the myocardium. Patients were divided into three groups according to the signal patterns of the infarcted myocardium on the T2WIs. The T2 values of the infarcted zones were compared on the T2 maps among the three groups. Validation of the T2 values was performed in the normal myocardium of seven healthy volunteers. There were no significant differences in mean T2WI-SI or T2 values in the normal myocardium of healthy volunteers compared to the remote myocardium of acute MI patients (p > 0.05). Mean SI on the T2WIs was significantly higher in the infarcted myocardium (81.3 ± 37.6) than in the remote myocardium (63.8 ± 18.1) (p < 0.05). The T2WIs showed high SI in ten patients (group 1), iso-SI in seven (group 2), and low SI in three (group 3) in the infarcted myocardium, compared to the remote myocardium. The T2 maps showed that T2 values in the infarcted myocardium had mostly increased, regardless of group, with values of 71 ± 9 ms in group 1, 64.9 ± 7.4 ms in group 2, and 61.4 ± 8.5 ms in group 3. T2 mapping is superior to T2WI for detecting areas of high SI in the infarcted myocardium. Therefore, quantitative T2 mapping sequences may be more useful and reliable in identifying myocardial edema in the infarcted myocardium than T2WI.
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Yonsei University Health System, Seoul 135-720, Republic of Korea.
authors.forename: Chul Hwan
authors.initials: CH
authors.lastname: Park
authors.forename: Eui-Young
authors.initials: EY
authors.lastname: Choi
authors.forename: Hyuck Moon
authors.initials: HM
authors.lastname: Kwon
authors.forename: Bum Kee
authors.initials: BK
authors.lastname: Hong
authors.forename: Byoung Kwon
authors.initials: BK
authors.lastname: Lee
authors.forename: Young Won
authors.initials: YW
authors.lastname: Yoon
authors.forename: Pil-Ki
authors.initials: PK
authors.lastname: Min
authors.forename: Andreas
authors.initials: A
authors.lastname: Greiser
authors.forename: Mun Young
authors.initials: MY
authors.lastname: Paek
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Yon Mi
authors.initials: YM
authors.lastname: Sung
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Hwang
authors.forename: Yoo Jin
authors.initials: YJ
authors.lastname: Hong
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004489:Edema, Cardiac / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis* / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D015607:Stents