title: Cervical screening test results associated with 265 histopathologic diagnoses of cervical glandular neoplasia.
abstract: OBJECTIVE
  To document screening test histories of women with histopathologic cervical glandular neoplasia (CGN) in a large integrated health system using new methods of cervical screening.
  
  
  METHODS
  Cervical screening test results were reviewed for 265 patients with histopathologic diagnoses of CGN, including 168 adenocarcinoma in situ, 80 invasive cervical adenocarcinoma, and 17 invasive cervical adenosquamous carcinoma cases.
  
  
  RESULTS
  Among 222 cases with known triggers of diagnostic studies, 211 (95%) had recent abnormal Papanicolaou (Pap) test results. Glandular cell abnormalities were the most common recent abnormal Pap test finding in 130 (61.6%) of 211; squamous cell abnormalities alone were documented in 81 (38.4%) of 211, reflecting coexisting cervical intraepithelial neoplasia (CIN) in 60% of CGN cases. Among 114 CGN cases with additional Pap tests more than 4 months to 3 years before CGN diagnosis, 70 (61.4%) had only earlier negative Pap test results. Among 72 CGN cases with recent human papillomavirus (HPV) test results, 70 (97.2%) tested HPV positive. Among 29 CGN cases with HPV test results more than 4 months to 3 years before CGN diagnosis, 25 (86.2%) tested HPV positive.
  
  
  CONCLUSIONS
  Conservative cytologic screening practices and HPV cotesting can facilitate early diagnoses of CGN.
authors.affiliation: Dept. of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, 300 Halket St, Pittsburgh, PA 15213, USA. zhaoc@upmc.edu
authors.forename: Chengquan
authors.initials: C
authors.lastname: Zhao
authors.forename: Zaibo
authors.initials: Z
authors.lastname: Li
authors.forename: R Marshall
authors.initials: RM
authors.lastname: Austin
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology* / Q000601:surgery / Q000821:virology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000209:etiology / Q000473:pathology* / Q000601:surgery / Q000821:virology; D018196:Carcinoma, Adenosquamous / Q000473:pathology* / Q000601:surgery / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D055088:Early Detection of Cancer; D005260:Female; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology* / Q000821:virology; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery / Q000821:virology; D014626:Vaginal Smears; D055815:Young Adult
chemical_list: D004279:DNA, Viral
keywords: AIS; Adenocarcinoma; Cervical glandular neoplasia; HPV; LBC; Pap cytology