title: Role of inflammasomes and their regulators in prostate cancer initiation, progression and metastasis.
abstract: Prostate cancer is one of the main cancers that affect men, especially older men. Though there has been considerable progress in understanding the progression of prostate cancer, the drivers of its development need to be studied more comprehensively. The emergence of resistant forms has also increased the clinical challenges involved in the treatment of prostate cancer. Recent evidence has suggested that inflammation might play an important role at various stages of cancer development. This review focuses on inflammasome research that is relevant to prostate cancer and indicates future avenues of study into its effective prevention and treatment through inflammasome regulation. With regard to prostate cancer, such research is still in its early stages. Further study is certainly necessary to gain a broader understanding of prostate cancer development and to create successful therapy solutions.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Louisville, Baxter II, Rm. 117, 580 S. Preston St., Louisville, KY 40202, USA. veeransr@gmail.com
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Veeranki
mesh_terms: D020170:Caspase 1 / Q000276:immunology* / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism; D020382:Interleukin-18 / Q000276:immunology* / Q000378:metabolism; D053583:Interleukin-1beta / Q000276:immunology* / Q000378:metabolism; D008297:Male; D018448:Models, Immunological; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
chemical_list: D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D020170:Caspase 1