title: Prognostic value of the immune microenvironment in lung adenocarcinoma.
abstract: We analyzed the immune microenvironment in the neoplastic and stromal components of Stage I lung adenocarcinoma lesions, finding that a high ratio of tumor-infiltrating FOXP3+regulatory T cells to CD3+lymphocytes, an elevated expression of the interleukin-7 receptor, as well as a reduced expression of the interleukin-12 receptor β2 all constitute independent factors of poor prognosis.
authors.affiliation: Division of Thoracic Service; Department of Surgery; Memorial Sloan-Kettering Cancer Center; New York, NY USA ; Department of Diagnostic Pathology; Faculty of Medicine; Kagawa University; Kagawa, Japan.
authors.forename: Kyuichi
authors.initials: K
authors.lastname: Kadota
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Nitadori
authors.forename: Prasad S
authors.initials: PS
authors.lastname: Adusumilli
keywords: FOXP3; interleukin-12 receptor; interleukin-7 receptor; lung adenocarcinoma