title: Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial.
abstract: BACKGROUND
  Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating hormone (TSH) levels on the prognosis of patients with endometrial cancer.
  
  
  METHODS
  Pre-therapeutic serum TSH was investigated in 199 patients with endometrial cancer. After stratification in TSH risk groups, univariate and multivariable survival analyses were performed.
  
  
  RESULTS
  Elevated TSH was independently associated with poor disease-specific survival in univariate/multivariable survival analyses (P=0.01 and P=0.03, respectively).
  
  
  CONCLUSIONS
  Thyroid-stimulating hormone may serve as a novel and independent prognostic parameter for disease-specific survival in patients with endometrial cancer.
authors.affiliation: Department of Gynaecology and Gynaecological Oncology, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
authors.forename: V
authors.initials: V
authors.lastname: Seebacher
authors.forename: G
authors.initials: G
authors.lastname: Hofstetter
authors.forename: S
authors.initials: S
authors.lastname: Polterauer
authors.forename: A
authors.initials: A
authors.lastname: Reinthaller
authors.forename: C
authors.initials: C
authors.lastname: Grimm
authors.forename: R
authors.initials: R
authors.lastname: Schwameis
authors.forename: S
authors.initials: S
authors.lastname: Taucher
authors.forename: A
authors.initials: A
authors.lastname: Wagener
authors.forename: C
authors.initials: C
authors.lastname: Marth
authors.forename: N
authors.initials: N
authors.lastname: Concin
mesh_terms: D000368:Aged; D016889:Endometrial Neoplasms / Q000097:blood* / Q000378:metabolism / Q000401:mortality*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D011379:Prognosis; D013961:Thyroid Gland / Q000502:physiology; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin