title: Low-grade myofibroblastic sarcoma of the larynx: a rare entity with review of literature.
abstract: Mesenchymal neoplasms of the larynx are rare and make up approximately 0.3% to 1.0% of all malignancies at this location. Low grade myofibroblastic sarcoma (LGMS) of larynx is a rare entity. We describe a rare case of LGMS of larynx who presented with complaint of hoarseness of voice. The patient was treated with total laryngectomy plus partial pharyngectomy followed by post-operative radiotherapy. Histopathologically, the lesion was composed of spindle cells that manifested variable cellular anaplasia and expressed smooth muscle actin (SMA) and focally S-100.One of the resection limits was involved so patient was given post-operative radiotherapy. The patient is alive and disease free 14 months after surgery. The characteristic clinical, histopathological features and treatment of this case are described with a literature review.
authors.affiliation: Department of Radiotherapy and Oncology, Regional Cancer Centre, Chandigarh, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Khosla
authors.forename: Budhi Singh
authors.initials: BS
authors.lastname: Yadav
authors.forename: Ritesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Sushmita
authors.initials: S
authors.lastname: Ghoshal
authors.forename: Kim
authors.initials: K
authors.lastname: Vaiphei
authors.forename: Roshan
authors.initials: R
authors.lastname: Verma
authors.forename: Suresh C
authors.initials: SC
authors.lastname: Sharma
mesh_terms: D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D007830:Larynx / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009379:Neoplasms, Muscle Tissue / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012509:Sarcoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery