title: [Autoantibodies to GAD and autoimmune-mediated neurological diseases].
abstract: Autoantibodies to GAD (GAD-Ab) are associated with stiff-person syndrome and cerebellar ataxia. Recent physiological studies have clarified that GAD-Ab causes cerebellar ataxia in high-titer GAD-Ab-positive ataxia. In rat cerebellar slices, the cerebrospinal fluid (CSF) from GAD-Ab-positive ataxia acted on the terminals of GABAergic interneurons to depress the GABA release on Purkinje cells. Reduction of spill-over GABA simultaneously attenuated the inhibition of glutamate release from neighboring excitatory synapses. Such a dual synaptic impairment, the depression at GABA synapses and the potentiation at glutamate synapses, would elicit a marked excitation of Purkinje cells. These pathogenic actions were diminished by absorption of GAD-Ab using recombinant GAD. Furthermore, it is reported that intra-administration of the CSF depressed the cerebellum-mediated inhibition on motor cortex. GAD-Ab would cause neurological symptoms depending on the epitope specificity.
authors.affiliation: Department of Medical Education, Tokyo Medical University.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitoma
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000134:cerebrospinal fluid / Q000276:immunology*; D020274:Autoimmune Diseases of the Nervous System / Q000175:diagnosis / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D005680:gamma-Aminobutyric Acid / Q000276:immunology
chemical_list: D001323:Autoantibodies; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase