title: The influence of spatial pulsed magnetic field application on neuropathic pain after tibial nerve transection in rat.
abstract: The purpose of the study was to examine the influence of the spatial variable magnetic field (induction: 150-300 µT, 80-150 µT, 20-80 µT; frequency 40 Hz) on neuropathic pain after tibial nerve transection. The experiments were carried out on 64 male Wistar C rats. The exposure of animals to magnetic field was performed 1 d/20 min., 5 d/week, for 28 d. Behavioural tests assessing the intensity of allodynia and sensitivity to mechanical and thermal stimuli were conducted 1 d prior to surgery and 3, 7, 14, 21 and 28 d after the surgery. The extent of autotomy was examined. Histological and immunohistochemical analysis was performed. The use of extremely low-frequency magnetic fields of minimal induction values (20-80 µT/40 Hz) decreased pain in rats after nerve transection. The nociceptive sensitivity of healthy rats was not changed following the exposition to the spatial magnetic field of the low frequency. The results of histological and immunohistochemical investigations confirm those findings. Our results indicate that extremely low-frequency magnetic field may be useful in the neuropathic pain therapy.
authors.affiliation: Department of Physiology, Medical University of Silesia, Katowice , Poland and.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Szajkowski
authors.forename: Wiesław
authors.initials: W
authors.lastname: Marcol
authors.forename: Adam
authors.initials: A
authors.lastname: Właszczuk
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Cieślar
authors.forename: Marita
authors.initials: M
authors.lastname: Pietrucha-Dutczak
authors.forename: Aleksander
authors.initials: A
authors.lastname: Sieroń
authors.forename: Joanna
authors.initials: J
authors.lastname: Lewin-Kowalik
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D055909:Magnetic Field Therapy / Q000379:methods*; D008297:Male; D009437:Neuralgia / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D013979:Tibial Nerve / Q000293:injuries* / Q000601:surgery