title: Acquired segmental neuromas.
abstract: Neuromas are benign hyperplastic proliferations of normal peripheral nerve components. These can be associated with some genodermatoses, namely Cowden syndrome and multiple endocrine neoplasia (MEN) 2B, especially when numerous lesions are present. Given the potential for malignancy (such as breast cancer, pheochromocytoma, and thyroid cancer) associated with these syndromes, other features indicative of either syndrome should be evaluated in patients presenting with multiple cutaneous neuromas. The evaluation should include a thorough family history and complete physical, dermatologic, and ophthalmologic exams as well as thyroid studies. We report, herein, the case of an 8-year-old female with cutaneous neuromas distributed segmentally with no other associated finding suggestive of an underlying syndrome.
authors.affiliation: Department of Dermatology, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico. braucristina@hotmail.com
authors.forename: Cristina N
authors.initials: CN
authors.lastname: Brau-Javier
authors.forename: Julio E
authors.initials: JE
authors.lastname: Sánchez
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Sánchez
mesh_terms: D001415:Back / Q000473:pathology; D001706:Biopsy; D002648:Child; D020405:Dermis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis; D006225:Hand / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D018814:Multiple Endocrine Neoplasia Type 2b / Q000175:diagnosis; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009463:Neuroma / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D063189:Symptom Assessment; D014953:Wrist / Q000473:pathology