title: Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation.
abstract: OBJECTIVE
  The goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a paraneoplastic syndrome usually associated with gynecologic cancers. There is little information about other dermatologic melanocytic findings in these patients.
  
  
  METHODS
  Histologic and fluorescent in situ hybridization (FISH) analysis of three separate skin biopsies, one of which was separated by 21 months from the others, were performed in a 71-year-old patient with BDUMP to assess for histologic and chromosomal abnormality. Conjunctival histologic evaluation was also done.
  
  
  RESULTS
  Dermal melanocytic proliferation was seen in each specimen. The cells were spindle type with mitotic activity. FISH analysis showed a normal copy of chromosomes. The conjunctival sample also showed normal FISH analysis.
  
  
  CONCLUSIONS
  BDUMP is associated with multifocal dermal and conjunctival melanocytic proliferation.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Pulido
authors.forename: T J
authors.initials: TJ
authors.lastname: Flotte
authors.forename: H
authors.initials: H
authors.lastname: Raja
authors.forename: S
authors.initials: S
authors.lastname: Miles
authors.forename: J L
authors.initials: JL
authors.lastname: Winters
authors.forename: R
authors.initials: R
authors.lastname: Niles
authors.forename: E A
authors.initials: EA
authors.lastname: Jaben
authors.forename: S N
authors.initials: SN
authors.lastname: Markovic
authors.forename: J
authors.initials: J
authors.lastname: Davies
authors.forename: K R
authors.initials: KR
authors.lastname: Kalli
authors.forename: R G
authors.initials: RG
authors.lastname: Vile
authors.forename: J J
authors.initials: JJ
authors.lastname: Garcia
authors.forename: D R
authors.initials: DR
authors.lastname: Salomao
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D049109:Cell Proliferation; D003229:Conjunctival Diseases / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D008544:Melanocytes / Q000473:pathology*; D059545:Paraneoplastic Syndromes, Ocular / Q000473:pathology*; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology*; D014603:Uveal Diseases / Q000209:etiology / Q000473:pathology*