title: Malignancies incidentally detected at lung transplantation: radiologic and pathologic features.
abstract: OBJECTIVE
  The purpose of this study was to assess the CT-pathologic features of cancer incidentally detected at lung transplantation.
  
  
  METHODS
  Our lung transplant registry was reviewed over 7 years for incidental malignancy. Patient demographics, diffuse lung disease, surgical procedure, histopathology, and chest CT were recorded. We correlated lesion size, morphology, multiplicity, and location with surgical and pathology reports and histopathology. Cancers were pathologically staged.
  
  
  RESULTS
  Of 759 lung transplant recipients, cancer was incidentally detected in 22 (2.9%). Half (11 of 258) or 4.3% were detected within the past 2 years. Four patients had a history of treated malignancy, and three had recurrence. Patients had emphysema (chronic obstructive pulmonary disease [COPD]) (n = 10), fibrosis (n = 10), or combined COPD and fibrosis (n = 2). Histopathology revealed 13 solitary lung carcinomas, four multifocal adenocarcinomas, three metastases, and two lymphoproliferative diseases. Lung cancer (n = 17) stages were I or II (n = 13), IIIA (n = 2), or IV (n = 2). Metastases (n = 3) and lymphoproliferative disease (n = 2) represented advanced disease. The interval between CT and surgery was a mean of 4 months. CT-positive cases (n = 10) represented lung cancer (n = 9) and posttrans-plantation lymphoproliferative disease (n = 1). Cases with no CT findings of malignancy (n = 12) included lung cancer (n = 8), metastases (n = 3), and lymphoma (n = 1). Ten cases (45%) had other histologically benign CT abnormalities that mimicked cancer.
  
  
  CONCLUSIONS
  Detection of incidental malignancy at lung transplantation has increased over the past 2 years. Malignancies were typically stage I or II lung cancers that were occult or indeterminate on CT. Diffuse lung disease, multiple CT abnormalities, and a delay between CT and transplantation compromise the preoperative diagnosis of cancer.
authors.affiliation: Department of Radiology, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, USA. strollodc@upmc.edu
authors.forename: Diane C
authors.initials: DC
authors.lastname: Strollo
authors.forename: Sanja
authors.initials: S
authors.lastname: Dacic
authors.forename: Iclal
authors.initials: I
authors.lastname: Ocak
authors.forename: Joseph
authors.initials: J
authors.lastname: Pilewski
authors.forename: Christian
authors.initials: C
authors.lastname: Bermudez
authors.forename: Maria M
authors.initials: MM
authors.lastname: Crespo
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016040:Lung Transplantation; D008232:Lymphoproliferative Disorders / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D057234:Preoperative Period; D012042:Registries; D014057:Tomography, X-Ray Computed / Q000379:methods*