title: Subthreshold depression and subjective cognitive complaints in Parkinson's disease.
abstract: OBJECTIVE
  Subthreshold depression (SubD) is characterized by clinically relevant depressive symptoms not meeting criteria for major depression. The possible association of SubD with subjective cognitive complaints and/or objective cognitive impairments was investigated in a sample of consecutive, non-demented Parkinson's disease (PD) outpatients.
  
  
  METHODS
  Amongst 115 patients, SubD was identified in 30 patients, major depression in 33; 36 patients were classified as non-depressed. Enrolled patients were administered tests and questionnaires validated in PD for assessing objective and subjective cognitive dysfunctions.
  
  
  RESULTS
  On objective cognitive measures SubD patients did not differ from non-depressed patients, whereas depressed patients achieved significantly lower scores than the other two groups. SubD and depressed patients reported more cognitive complaints than non-depressed patients.
  
  
  CONCLUSIONS
  SubD is a non-motor aspect of PD that is not related to objective cognitive deficits but is associated with subjective cognitive complaints, thus impacting on patients' well-being.
authors.affiliation: Department of Psychology, Second University of Naples, Caserta, Italy; IDC Hermitage-Capodimonte, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Santangelo
authors.forename: C
authors.initials: C
authors.lastname: Vitale
authors.forename: L
authors.initials: L
authors.lastname: Trojano
authors.forename: M G
authors.initials: MG
authors.lastname: Angrisano
authors.forename: M
authors.initials: M
authors.lastname: Picillo
authors.forename: D
authors.initials: D
authors.lastname: Errico
authors.forename: V
authors.initials: V
authors.lastname: Agosti
authors.forename: D
authors.initials: D
authors.lastname: Grossi
authors.forename: P
authors.initials: P
authors.lastname: Barone
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000209:etiology*; D003863:Depression / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications*; D011569:Psychiatric Status Rating Scales
keywords: Parkinson's disease; cognitive dysfunctions; depression; subjective cognitive complaints; subthreshold depression