title: Canine indolent and aggressive lymphoma: clinical spectrum with histologic correlation.
abstract: Sixty-three dogs with newly diagnosed lymphoma underwent complete staging and received the same chemotherapy. Diffuse large B-cell lymphoma was the leading histotype (44.4%), followed by peripheral T-cell lymphoma (20.6%). Indolent lymphomas accounted for 30.2% of cases. Most dogs with aggressive B-cell lymphoma had stage IV disease. Dogs with indolent and aggressive T-cell lymphoma had more often stage V disease and were symptomatic. Liver and bone marrow were predominantly involved in B-cell and T-cell lymphoma, respectively. The clinical stage was significantly related to substage, sex and total lactic dehydrogenase (LDH) levels. Aggressive B-cell lymphomas were more likely to achieve remission. Median survival was 55 days for aggressive and indolent T-cell lymphoma, 200 and 256 days for indolent and aggressive B-cell lymphoma, respectively. The prognosis of advanced indolent lymphoma does not appear to be appreciably different from that of aggressive disease. Familiarity with the various histotypes is critical to make the correct diagnosis and drive therapy.
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Aresu
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, Milan, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Martini
authors.affiliation: Centro Oncologico Veterinario, Sasso Marconi, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.affiliation: Clinica Veterinaria dell'Orologio, Sasso Marconi, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Vignoli
authors.affiliation: Centro Oncologico Veterinario, Sasso Marconi, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Sampaolo
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Aricò
authors.affiliation: Centro Oncologico Veterinario, Sasso Marconi, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Laganga
authors.affiliation: Centro Oncologico Veterinario, Sasso Marconi, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pierini
authors.affiliation: Urodelia, St Lys, France.
authors.forename: P
authors.initials: P
authors.lastname: Frayssinet
authors.affiliation: Department of Agronomy Food Natural Resources Animals & Environment, University of Padova, Legnaro, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Mantovani
authors.affiliation: Centro Oncologico Veterinario, Sasso Marconi, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Marconato
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D004285:Dogs; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008223:Lymphoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000662:veterinary; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000662:veterinary; D008297:Male; D009367:Neoplasm Staging / Q000662:veterinary; D011379:Prognosis
chemical_list: D007770:L-Lactate Dehydrogenase
keywords: clinical stage; dog; histological subtype; lymphoma