title: Clomiphene citrate in the management of male infertility.
abstract: Clomiphene citrate, a selective estrogen receptor modulator, has been used to treat infertility in women and men for 50 years. In men, clomiphene citrate has been employed in the management of unexplained infertility, oligo and asthenospermia, hypogonadism, and nonobstructive azoospermia. The available evidence reveals mixed results and suggests that clomiphene citrate may be appropriate for the management of male infertility in specific clinical scenarios. Further research is needed to clarify when clomiphene citrate is indicated in the treatment of male infertility.
authors.affiliation: Department of Obstetrics and Gynecology.
authors.forename: Lauren W
authors.initials: LW
authors.lastname: Roth
authors.forename: Amanda R
authors.initials: AR
authors.lastname: Ryan
authors.forename: Randall B
authors.initials: RB
authors.lastname: Meacham
mesh_terms: D053627:Asthenozoospermia / Q000188:drug therapy / Q000503:physiopathology; D053713:Azoospermia / Q000188:drug therapy / Q000503:physiopathology; D002996:Clomiphene / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000503:physiopathology; D007248:Infertility, Male / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D009845:Oligospermia / Q000188:drug therapy / Q000503:physiopathology; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*
chemical_list: D020845:Selective Estrogen Receptor Modulators; D002996:Clomiphene