title: "License to kill" reflects joint action of CD4 and CD8 T cells.
abstract: The spontaneous T-cell responses to the KIF20A cancer-associated antigen found by Tomita and colleagues among peripheral blood mononuclear cells of patients with cancer, but not healthy people, involve both CD4 and CD8 T cells. Synthetic long peptides of KIF20A stimulate synergy between these two T-cell types to promote cancer cell killing.
authors.affiliation: ISA Pharmaceuticals and Leiden University Medical Center, Leiden, the Netherlands. cmelief@lumc.nl
authors.forename: Cornelis J M
authors.initials: CJ
authors.lastname: Melief
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D005260:Female; D006801:Humans; D016547:Kinesins / Q000276:immunology*; D008297:Male; D009369:Neoplasms / Q000276:immunology*; D010455:Peptides / Q000276:immunology*
chemical_list: D018984:Epitopes, T-Lymphocyte; C410089:KIF20A protein, human; D010455:Peptides; D016547:Kinesins