title: Targeting triple negative breast cancer cells by N3-substituted 9,10-phenanthrenequinone thiosemicarbazones and their metal complexes.
abstract: Novel N(3)-substituted 9,10-Phenanthrenequinone thiosemicarbazones and their copper, nickel and palladium complexes are structurally characterized and reported along with the single crystal X-ray structures of three ligands and one nickel complex. All compounds were evaluated for their antiproliferative potential against Triple Negative Breast Cancer (TNBC) cells which have poor prognosis and no effective drugs to treat with. All compounds exhibited antiproliferative activity against these cells. Among the metal complexes evaluated, redox active copper complexes were found to be more potent. The possible mechanism for such enhanced activity can be attributed to the generation of oxidative stress, which was amenable for targeting through metal complexation.
authors.affiliation: Department of Life & Physical Sciences, Lincoln University, Jefferson City, MO 65101, USA. afrasiabiz@lincolnu.edu
authors.forename: Zahra
authors.initials: Z
authors.lastname: Afrasiabi
authors.forename: Preston
authors.initials: P
authors.lastname: Stovall
authors.forename: Kristen
authors.initials: K
authors.lastname: Finley
authors.forename: Amitava
authors.initials: A
authors.lastname: Choudhury
authors.forename: Charles
authors.initials: C
authors.lastname: Barnes
authors.forename: Aamir
authors.initials: A
authors.lastname: Ahmad
authors.forename: Fazlul
authors.initials: F
authors.lastname: Sarkar
authors.forename: Alok
authors.initials: A
authors.lastname: Vyas
authors.forename: Subhash
authors.initials: S
authors.lastname: Padhye
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001940:Breast / Q000166:cytology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D008958:Models, Molecular; D010616:Phenanthrenes / Q000737:chemistry / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000737:chemistry / Q000494:pharmacology*; D064726:Triple Negative Breast Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D010616:Phenanthrenes; D013882:Thiosemicarbazones; C479020:phenanthrenequinone thiosemicarbazone; C005399:9,10-phenanthrenequinone; D003300:Copper
keywords: 9,10-Phenanthrenequinone; Antiproliferative activity; Copper complex; N(3)-substituted thiosemicarbazones; Triple negative breast cancer