title: Intrahepatic cholestasis of pregnancy: biochemical predictors of adverse perinatal outcomes.
abstract: This study aimed to identify biochemical predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy (ICP). A total of 106 ICP cases were analyzed retrospectively by the combination of receiver operating characteristic curve and binary logistic regression analysis. "Adverse perinatal outcomes" included spontaneous preterm labor, meconium-staining of amniotic fluid, stillbirth and Apgar score ≤7 at 1 or 5 min. Total bile acid (TBA) [AUC=0.658, 95%CI (0.536, 0.781), P=0.031] was a valuable predictor for adverse perinatal outcomes. The critical value of TBA above which adverse perinatal outcomes were observed was 40.15 μmol/L (Youden's index=0.3). Binary multivariate logistic regression analysis revealed that the risk of adverse perinatal outcomes increased when TBA ≥40.15 μmol/L [OR=3.792, 95%CI (1.226, 11.727), P=0.021]. It is concluded that the risk of adverse perinatal outcomes in ICP increases when maternal TBA ≥40.15 μmol/L.
authors.affiliation: Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.|Department of Obstetrics, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. dr.deng@tjh.tjmu.edu.cn.
authors.forename: Dong-Rui
authors.initials: DR
authors.lastname: Deng
authors.affiliation: Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Hao
authors.affiliation: Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Dang
authors.affiliation: Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis*; D015415:Biomarkers / Q000378:metabolism; D002681:China; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000378:metabolism*; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D050497:Stillbirth; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*; D055815:Young Adult
chemical_list: D001647:Bile Acids and Salts; D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances