title: Programming of osteoporosis and impact on osteoporosis risk.
abstract: Osteoporosis is a skeletal disorder characterized by reduced bone quantity and quality and an increased susceptibility to fracture, and seems to be one of many chronic conditions that might be influenced by events early in life. Specifically, there is growing evidence of an interaction between the genome and the environment in the expression of the disease.
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, S016 6YD, UK. emd@mrc.soton.ac.uk
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Dennison
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Harvey
authors.forename: Cyrus
authors.initials: C
authors.lastname: Cooper
mesh_terms: D044127:Epigenesis, Genetic; D005260:Female; D048070:Fetal Nutrition Disorders / Q000235:genetics*; D050723:Fractures, Bone / Q000196:embryology / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D059647:Gene-Environment Interaction; D006801:Humans; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D010024:Osteoporosis / Q000196:embryology / Q000235:genetics*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000235:genetics*; D039401:Prenatal Nutritional Physiological Phenomena