title: The two faces of regulatory T cells in cancer.
abstract: Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients.
authors.affiliation: Robert H. Lurie Comprehensive Cancer Center; Northwestern University; Chicago, IL USA.
authors.forename: Nichole R
authors.initials: NR
authors.lastname: Blatner
authors.forename: Fotini
authors.initials: F
authors.lastname: Gounari
authors.forename: Khashayarsha
authors.initials: K
authors.lastname: Khazaie
keywords: RORγt; Treg; colon-cancer; inflammation; polyposis