title: Inhibitory effect of catechin-related compounds on renin activity.
abstract: Renin is a crucial enzyme in the renin-angiotensin system, and the inhibition of its activity is considered as a useful approach to the treatment of hypertension. The inhibitory effect of catechin-related compounds on renin was investigated in this work. It was found that epigallocatechin gallate (EGCg) possessed the strongest activity with an IC₅₀ value of 44.53 μM and acted in an uncompetitive manner. Gallated catechins exerted higher inhibition than the ungallated forms, and gallic acid exhibited an inhibitory potency close to that of epicatechin gallate (ECg). Results indicated that the galloyl moiety and ortho-trihydroxy phenyl structures might be favorable for the renin-inhibitory activity of these compounds.
authors.affiliation: National Food Research Institute, National Agricultural and Food Research Organization, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Li
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kohji
authors.initials: K
authors.lastname: Yamaki
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry*; D057075:Enzyme Assays; D005707:Gallic Acid / Q000737:chemistry*; D006801:Humans; D011994:Recombinant Proteins / Q000737:chemistry; D012083:Renin / Q000737:chemistry; D012996:Solutions; D013329:Structure-Activity Relationship; D013662:Tea / Q000737:chemistry; D000092502:Renin Inhibitors
chemical_list: D000959:Antihypertensive Agents; D002392:Catechin; D005707:Gallic Acid; D011994:Recombinant Proteins; D012083:Renin; D012996:Solutions; D013662:Tea; D000092502:Renin Inhibitors; C062669:epicatechin gallate; C045651:epigallocatechin gallate; C057580:gallocatechol