title: Curative effect of pleural lavage on open chest trauma caused by seawater immersion.
abstract: OBJECTIVE
  Open chest trauma with seawater immersion can lead systematic inflammatory response and multiple organ dysfunction syndromes (MODS). Early intervention of seawater immersion significantly decreases mortality. This study aims to explore the curative effect of pleural lavage in the treatment of open chest trauma caused by seawater immersion on dogs.
  
  
  METHODS
  An in vivo experimental study was performed in healthy cross-breeding adult dogs (n=20).
  
  
  METHODS
  A dog model of open chest trauma caused by seawater immersion was established. All experimental dogs were divided into control group and pleural lavage group, with 10 dogs in each group. In the control group, dogs were performed ventilator-assisted breathing, and thoracic tube was kept open for adequate chest water drainage; in the pleural lavage group, dogs were further injected with 0.9% sodium chloride (35 mL/kg) immediately into the right side of the chest after the pleural effusion was drained off. The internal environment, oxygen partial pressure, and pathological changes of the lung tissue were observed and recorded.
  
  
  RESULTS
  Following open chest trauma caused by seawater immersion, both groups showed obviously increased serum sodium and plasma osmolality and sharply decreased oxygen partial pressure. After treatment, the serum sodium and plasma osmolality decreased, whereas oxygen partial pressure increased in both groups. The pleural lavage group showed better improvement than the conventional treatment group. The pathological changes in the pleural group were lighter than in the conventional treatment group.
  
  
  CONCLUSIONS
  Compared with conventional treatment, repeated pleural lavage shows improved treatment in the correction of blood hypertonic state and hypoxemia in seawater-immersed open chest trauma.
authors.affiliation: PLA 117 Hospital, Center of Cardiothoracic Surgery, No.14 Lingyin Road, Hangzhou, Zhejiang Province, China. bchenzj@163.com
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.forename: Zhong-Yuan
authors.initials: ZY
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xiong-Wei
authors.initials: XW
authors.lastname: Li
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D000860:Hypoxia / Q000209:etiology / Q000628:therapy; D008168:Lung / Q000473:pathology; D010100:Oxygen / Q000378:metabolism; D010313:Partial Pressure; D035422:Pleural Cavity; D010996:Pleural Effusion / Q000209:etiology / Q000628:therapy*; D012623:Seawater; D007507:Therapeutic Irrigation / Q000379:methods*; D013898:Thoracic Injuries / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D010100:Oxygen