title: Metal-free decarboxylative three-component coupling reaction for the synthesis of propargylamines.
abstract: A metal-free decarboxylative three-component coupling reaction was developed. When alkynyl carboxylic acids, paraformaldehyde, and amines were reacted in CH3CN at 65 °C for 3 h, the desired propargylamines were obtained in good yields. This coupling reaction also showed good yield in water solvent. This reaction showed higher selectivity toward alkynyl carboxylic acids than a terminal alkyne.
authors.affiliation: Department of Chemistry, Chonnam National University, Gwangju, 500-757, Republic of Korea.
authors.forename: Kyungho
authors.initials: K
authors.lastname: Park
authors.forename: Yumi
authors.initials: Y
authors.lastname: Heo
authors.forename: Sunwoo
authors.initials: S
authors.lastname: Lee