title: Continuous parallel ESI-MS analysis of reactions carried out in a bespoke 3D printed device.
abstract: Herein, we present an approach for the rapid, straightforward and economical preparation of a tailored reactor device using three-dimensional (3D) printing, which can be directly linked to a high-resolution electrospray ionisation mass spectrometer (ESI-MS) for real-time, in-line observations. To highlight the potential of the setup, supramolecular coordination chemistry was carried out in the device, with the product of the reactions being recorded continuously and in parallel by ESI-MS. Utilising in-house-programmed computer control, the reactant flow rates and order were carefully controlled and varied, with the changes in the pump inlets being mirrored by the recorded ESI-MS spectra.
authors.affiliation: School of Chemistry, University of Glasgow, G12 8QQ, United Kingdom.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Mathieson
authors.forename: Mali H
authors.initials: MH
authors.lastname: Rosnes
authors.forename: Victor
authors.initials: V
authors.lastname: Sans
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Kitson
authors.forename: Leroy
authors.initials: L
authors.lastname: Cronin
keywords: 3D printing; ESI-MS; continuous parallel analysis; reactionware; supramolecular chemistry