title: Electrochemical synthesis of azanucleoside derivatives using a lithium perchlorate-nitromethane system.
abstract: We have developed a highly efficient synthetic method for azanucleosides using a lithium perchlorate-nitromethane reaction medium, allowing direct and exclusive installation of various nucleophiles, including protected nucleobases into prolinol derivatives at the preferred 5-position.
authors.affiliation: Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
authors.forename: Shokaku
authors.initials: S
authors.lastname: Kim
authors.forename: Takao
authors.initials: T
authors.lastname: Shoji
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kitano
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Chiba
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D055664:Electrochemical Techniques; D018020:Lithium Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D009595:Nitroparaffins / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D010472:Perchlorates / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D018020:Lithium Compounds; D009595:Nitroparaffins; D009705:Nucleosides; D010472:Perchlorates; D011759:Pyrrolidines; C010509:prolinol; D008697:Methane; C054684:lithium perchlorate; C008640:nitromethane