title: Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer.
abstract: OBJECTIVE
  This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis.
  
  
  METHODS
  A single-center cohort study was conducted with 86 patients who had undergone radical hysterectomy for stage I cervical cancer. Prognostic factors and the presence of HPV 16 and 18 were analyzed using a polymerase chain reaction assay. A univariate analysis using Kaplan-Meier curves was conducted to estimate survival.
  
  
  RESULTS
  The prevalence of HPV 16 in the study group was 65.3%, and the prevalence of HPV 18 was 33.3%. The prevalence of infection with both viruses was 26.9%. Overall survival at 5 years was 91% among women with HPV 18 and 96% among those without this virus type (p=0.133). Among the women with HPV 16, the overall survival was 94%, whereas this rate was 96% among those without this virus type (p=0.663). Disease-free survival was unaffected by the presence of HPV type 16 or 18.
  
  
  CONCLUSIONS
  In the present study, despite the high prevalence of HPV types 16 and 18, the presence of these virus types did not affect the prognosis of patients with stage I cervical cancer who underwent radical hysterectomy.
authors.affiliation: Araújo Jorge Hospital, Goiás Anticancer Association, Goiânia/GO, Brazil.
authors.forename: Rossana de Araújo Catão
authors.initials: Rde A
authors.lastname: Zampronha
authors.forename: Ruffo
authors.initials: R
authors.lastname: Freitas-Junior
authors.forename: Eddie Fernando Candido
authors.initials: EF
authors.lastname: Murta
authors.forename: Márcia Antoniazi
authors.initials: MA
authors.lastname: Michelin
authors.forename: Aline Almeida
authors.initials: AA
authors.lastname: Barbaresco
authors.forename: Sheila Jorge
authors.initials: SJ
authors.lastname: Adad
authors.forename: Amaurillo Monteiro de
authors.initials: AM
authors.lastname: Oliveira
authors.forename: Amanda B
authors.initials: AB
authors.lastname: Rassi
authors.forename: Glória Jabur Bittar
authors.initials: GJ
authors.lastname: Oton
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D006801:Humans; D007045:Hysterectomy, Vaginal; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000401:mortality / Q000821:virology*; D016612:Paraffin Embedding; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000821:virology*