title: Acceleration of X-chromosome gene order evolution in the cattle lineage.
abstract: The gene order on the X chromosome of eutherians is generally highly conserved, although an increase in the rate of rearrangement has been reported in the rodent lineage. Conservation of the X chromosome is thought to be caused by selection related to maintenance of dosage compensation. However, we herein reveal that the cattle (Btau4.0) lineage has experienced a strong increase in the rate of X-chromosome rearrangement, much stronger than that previously reported for rodents. We also show that this increase is not matched by a similar increase on the autosomes and cannot be explained by assembly errors. Furthermore, we compared the difference in two cattle genome assemblies: Btau4.0 and Btau6.0 (Bos taurus UMD3.1). The results showed a discrepancy between Btau4.0 and Btau6.0 cattle assembly version data, and we believe that Btau6.0 cattle assembly version data are not more reliable than Btau4.0.
authors.affiliation: Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Korea.
authors.forename: Woncheoul
authors.initials: W
authors.lastname: Park
authors.forename: Hee-Seok
authors.initials: HS
authors.lastname: Oh
authors.forename: Heebal
authors.initials: H
authors.lastname: Kim
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002417:Cattle; D002874:Chromosome Mapping / Q000662:veterinary; D008040:Genetic Linkage; D016678:Genome; D006801:Humans; D014960:X Chromosome