title: Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells.
abstract: OBJECTIVE
  To evaluate the effect of combined use of rapamycin and cisplatin against Hela cells in vitro.
  
  
  METHODS
  The inhibitory effects of rapamycin and cisplatin, used alone or combination, on the proliferation of Hela cell were measured with MTT assay and median-effect plot analysis.
  
  
  RESULTS
  Combined use of rapamycin and cisplatin significantly improved the chemotherapeutic effect against Hela cells. The inhibitory rates were dose-dependent. Rapamycin and cisplatin showed synergistic effects in the chemotherapy of Hela cells (q > 1.15, King's formula).
  
  
  CONCLUSIONS
  Combined use of rapamycin and cisplatin significantly improves the chemotherapeutic effect against Hela cells.
authors.affiliation: Dalian Obstetrics and Gynecology Hospital, Dalian, Liaoning, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Han
authors.forename: Jie-Ling
authors.initials: JL
authors.lastname: Wu
authors.forename: Li-Xiao
authors.initials: LX
authors.lastname: Yang
keywords: Hela cells; cervical carcinoma; cisplatin; rapamycin