title: Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections.
abstract: Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus.
authors.affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, South East Asia Infectious Diseases Clinical Research Network, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. tanlv@oucru.org
authors.forename: Le Van
authors.initials: le V
authors.lastname: Tan
authors.forename: H Rogier
authors.initials: HR
authors.lastname: van Doorn
authors.forename: Ho Dang Trung
authors.initials: HD
authors.lastname: Nghia
authors.forename: Tran Thi Hong
authors.initials: TT
authors.lastname: Chau
authors.forename: Le Thi Phuong
authors.initials: le TP
authors.lastname: Tu
authors.forename: Michel
authors.initials: M
authors.lastname: de Vries
authors.forename: Marta
authors.initials: M
authors.lastname: Canuti
authors.forename: Martin
authors.initials: M
authors.lastname: Deijs
authors.forename: Maarten F
authors.initials: MF
authors.lastname: Jebbink
authors.forename: Stephen
authors.initials: S
authors.lastname: Baker
authors.forename: Juliet E
authors.initials: JE
authors.lastname: Bryant
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Tham
authors.forename: Nguyen Thi Thuy Chinh
authors.initials: NT
authors.lastname: BKrong
authors.forename: Maciej F
authors.initials: MF
authors.lastname: Boni
authors.forename: Tran Quoc
authors.initials: TQ
authors.lastname: Loi
authors.forename: Le Thi
authors.initials: le T
authors.lastname: Phuong
authors.forename: Joost T P
authors.initials: JT
authors.lastname: Verhoeven
authors.forename: Martin
authors.initials: M
authors.lastname: Crusat
authors.forename: Rienk E
authors.initials: RE
authors.lastname: Jeeninga
authors.forename: Constance
authors.initials: C
authors.lastname: Schultsz
authors.forename: Nguyen Van Vinh
authors.initials: NV
authors.lastname: Chau
authors.forename: Tran Tinh
authors.initials: TT
authors.lastname: Hien
authors.forename: Lia
authors.initials: L
authors.lastname: van der Hoek
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
authors.forename: Menno D
authors.initials: MD
authors.lastname: de Jong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002494:Central Nervous System Infections / Q000453:epidemiology / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D018136:Circoviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D018173:Circoviridae Infections / Q000453:epidemiology / Q000821:virology*; D016000:Cluster Analysis; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D016679:Genome, Viral; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D015995:Prevalence; D011446:Prospective Studies; D017422:Sequence Analysis, DNA; D014744:Vietnam; D055815:Young Adult
chemical_list: D004279:DNA, Viral