title: The value of serum osteoprotegerin levels in patients with angina like chest pain undergoing diagnostic coronary angiography.
abstract: BACKGROUND
  Osteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily.Recent evidence supports a relationship between serum OPG level and atherosclerosis. The aim of this study was to evaluate the possible association of OPG with the presence of coronary artery disease (CAD), its severity and prognosis in patients with chest pain and suspected coronary stenosis.
  
  
  METHODS
  In this cross-sectional analytic study, 180 candidates of elective coronary artery angiography were recruited. Serum level of OPG was measured by ELISA method in all patients and its relation with presence and severity of CAD based on a coronary atherosclerosis score (CAS) was assessed. Patients were followed for a mean period of about 24 ± 3.2 months and the relationship between OPG levels and future cardiac events were evaluated.
  
  
  RESULTS
  The mean serum level of OPG was 1637 ± 226 pg/mL in those with CAD and 1295 ± 185 pg/mL (nonparametric p = 0.001) in those without it. There was a significant direct correlation between the level of serum OPG and CAS (rho = 0.225, p = 0.002). The optimalcut-off point for predicting a significant coronary artery obstruction was a serum level of≥ 1412 pg/mL with a sensitivity and specificity of 60% and 57.8%, respectively. Major adversecardiac events (MACE) including cardiovascular death, admission with acute coronary syndrome,or heart failure, was significantly higher in those with higher OPG levels (22 [34.3%]vs. 15 [16%], p = 0.012).
  
  
  CONCLUSIONS
  There was a direct and significant correlation between the serum level of OPG and CAS. MACE occurred more commonly in those with higher baseline OPG levels.
authors.affiliation: a_yaghoubi@ymail.com.
authors.forename: Samad
authors.initials: S
authors.lastname: Ghaffari
authors.forename: Alireza
authors.initials: A
authors.lastname: Yaghoubi
authors.forename: Roya
authors.initials: R
authors.lastname: Baghernejad
authors.forename: Nariman
authors.initials: N
authors.lastname: Sepehrvand
authors.forename: Sepideh
authors.initials: S
authors.lastname: Sokhanvar
authors.forename: Amir Ghorbani
authors.initials: AG
authors.lastname: Haghjou
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000209:etiology* / Q000401:mortality; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality; D023921:Coronary Stenosis / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human