title: Sodium hydroxide catalyzed N-alkylation of (hetero) aromatic primary amines and N1,C5-dialkylation of 4-phenyl-2-aminothiazoles with benzyl alcohols.
abstract: In the presence of a catalytic amount of NaOH, the selective N-alkylation of various heteroaromatic primary amines is reported. With 1 equiv of NaOH, N1,C5-dialkylation of 4-phenyl-2-aminothiazoles has been investigated. Reaction of in situ generated aldehyde with amine yields the N-alkylated and N1,C5-dialkylated products through hydride ion transformation from alcohol.
authors.affiliation: Academy of Scientific & Innovative Research, CSIR-Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar-364 002, Gujarat, India.
authors.forename: Ramachandra Reddy
authors.initials: RR
authors.lastname: Donthiri
authors.forename: Venkatanarayana
authors.initials: V
authors.lastname: Pappula
authors.forename: Darapaneni Chandra
authors.initials: DC
authors.lastname: Mohan
authors.forename: Hiren H
authors.initials: HH
authors.lastname: Gaywala
authors.forename: Subbarayappa
authors.initials: S
authors.lastname: Adimurthy
mesh_terms: D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D019905:Benzyl Alcohol / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D012972:Sodium Hydroxide / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000588:Amines; D013844:Thiazoles; D012972:Sodium Hydroxide; D019905:Benzyl Alcohol