title: Asynchronous onset of clinical disease in BSE-infected macaques.
abstract: To estimate the effect of the variability of prion disease onset on primary bovine spongiform encephalopathy transmission to humans, we studied 6 cynomolgus macaques. The preclinical incubation period was significantly prolonged in 2 animals, implying that onset of variant Creutzfeldt-Jacob disease in humans could be more diverse than previously expected.
authors.affiliation: German Primate Center, Göttingen, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Montag
authors.forename: Walter
authors.initials: W
authors.lastname: Schulz-Schaeffer
authors.forename: Annette
authors.initials: A
authors.lastname: Schrod
authors.forename: Gerhard
authors.initials: G
authors.lastname: Hunsmann
authors.forename: Dirk
authors.initials: D
authors.lastname: Motzkus
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D016643:Encephalopathy, Bovine Spongiform / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008252:Macaca fascicularis; D018620:PrPSc Proteins / Q000378:metabolism
chemical_list: D018620:PrPSc Proteins
keywords: BSE; Creutzfeldt-Jakob disease; Macaca fascicularis; Prion disease transmission; bovine spongiform encephalopathy; prions