title: Temperature controlled machine perfusion system for liver.
abstract: Organ preservation using machine perfusion is an effective method compared with conventional preservation techniques using static cold storage. A newly developed MP preservation system to control perfusate temperatures from hypothermic to subnormothermic conditions is introduced. This system is useful not only for liver preservation, but also for evaluation of graft viability for recovery. This novel method has been proposed for preservation of porcine liver grafts. An innovative preservation system is especially important to obtain viable organs from extended criteria or donation after cardiac death donors. In this study, we introduce a new machine perfusion preservation system (NES-01) to evaluate graft viability for recovery of liver functions, using porcine grafts.
authors.affiliation: Department of Mechanical Engineering, Tokyo Metroplitan University, Tokyo, Japan. obara@tmu.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Obara
authors.forename: N
authors.initials: N
authors.lastname: Matsuno
authors.forename: T
authors.initials: T
authors.lastname: Shigeta
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: S
authors.initials: S
authors.lastname: Enosawa
authors.forename: H
authors.initials: H
authors.lastname: Mizunuma
mesh_terms: D000818:Animals; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D016031:Liver Transplantation; D019188:Organ Preservation Solutions; D010477:Perfusion; D013552:Swine; D013696:Temperature
chemical_list: D019188:Organ Preservation Solutions; D007770:L-Lactate Dehydrogenase