title: ADHD, autism spectrum disorder, temperament, and character: phenotypical associations and etiology in a Swedish childhood twin study.
abstract: OBJECTIVE
  To explore the links between neurodevelopmental disorders - attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) - and personality in a population-based, genetically sensitive study of children.
  
  
  METHODS
  A population-based sample of 1886 twins aged 9 and 12, enriched for childhood mental health problems, was recruited from the Child and Adolescent Twin Study in Sweden (CATSS). Parents were interviewed over the telephone using the Autism-Tics, AD/HD and other Comorbidities (A-TAC) inventory, and in a second step they rated their children according to the Junior Temperament and Character Inventory (JTCI).
  
  
  RESULTS
  ADHD was strongly correlated with novelty seeking, while ASD was correlated positively with harm avoidance and negatively with reward dependence. The strongest associations between personality traits and neurodevelopmental disorders were negative correlations between the character dimensions of self-directedness and cooperativeness and ADHD and ASD alike. Cross-twin cross-trait correlations between ADHD, ASD, and personality dimensions in monozygotic twins were more than double those in dizygotic twins, indicating a strong genetic effect behind the phenotypic covariation between neurodevelopmental disorders and personality.
  
  
  CONCLUSIONS
  Neurodevelopmental disorders are linked specifically to particular temperament profiles and generally to hampered development of the self-governing strategies referred to as "character." Poor self-agency and cooperation may be core functional outcomes in the separation of children with handicapping conditions from those with traits only reminiscent of neurodevelopmental disorders. The associations between neurodevelopmental disorders and personality are at least partly due to genetic effects influencing both conditions. As a consequence, personality must be broadly considered in neuropsychiatry, just as neuropsychiatric disorders and their genetic, neurodevelopmental, and cognitive susceptibilities have to be in personality research and clinical treatment.
authors.affiliation: Centre for Ethics, Law and Mental Health (CELAM), University of Gothenburg, Sweden; Swedish Prison and Probation Services, R&D Unit, Gothenburg, Sweden. Electronic address: nora.kerekes@neuro.gu.se.
authors.forename: Nóra
authors.initials: N
authors.lastname: Kerekes
authors.forename: Sven
authors.initials: S
authors.lastname: Brändström
authors.forename: Sebastian
authors.initials: S
authors.lastname: Lundström
authors.forename: Maria
authors.initials: M
authors.lastname: Råstam
authors.forename: Thomas
authors.initials: T
authors.lastname: Nilsson
authors.forename: Henrik
authors.initials: H
authors.lastname: Anckarsäter
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D002605:Character; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D004200:Diseases in Twins / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D010551:Personality / Q000502:physiology*; D010641:Phenotype; D012042:Registries; D013548:Sweden / Q000453:epidemiology; D013694:Temperament / Q000502:physiology; D014429:Twins, Dizygotic / Q000523:psychology / Q000706:statistics & numerical data; D014430:Twins, Monozygotic / Q000523:psychology / Q000706:statistics & numerical data