title: Association between the hepatitis B and C viruses and metabolic diseases in patients stratified by age.
abstract: BACKGROUND
  Hepatitis B/C viruses cause liver disease and metabolic disturbances.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the association between hepatitis B/C infection and metabolic syndrome (MS).
  
  
  METHODS
  In total, 26,305 subjects were included in this multicentre, cross-sectional study. Systolic and diastolic blood pressures, body mass index and waist circumference were measured. Total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, fasting blood glucose and uric acid were determined, and hepatitis B serum antigen (HBsAg) and anti-HCV antibodies were assayed using commercial kits.
  
  
  RESULTS
  MS was diagnosed in 2712 (23.0%) females, including 131 and 166 positive for HBsAg and anti-HCV respectively. In the men, 4594 (31.6%) were diagnosed with MS, including 326 positive for HBsAg and 131 positive for anti-HCV. No significant difference in the prevalence of MS was identified in any group, except men and women >45 years who were anti-HCV positive. Various metabolic alterations in both men and women >45 years were noted, including waist circumference, body mass index, fasting blood glucose and systolic and diastolic blood pressure. Notably, high- and low-density lipoproteins were significantly lower in positive subjects compared to those weakly positive and/or negative for anti-HCV.
  
  
  CONCLUSIONS
  There were obvious metabolic derangements in patients coinflicted with MS and hepatitis C infections, particularly those >45 years of age. There is a pressing need to identify strategies to improve/resolve metabolic derangements to maximize sustained virological response rates in patients infected with HCV (and potentially HBV).
authors.affiliation: Department of Occupation Medicine, Keelung Chang-Gung Memorial Hospital, Keelung, Taiwan. 620313@adm.cgmh.org.tw
authors.forename: Wen-Cheng
authors.initials: WC
authors.lastname: Li
authors.forename: Yi-Yen
authors.initials: YY
authors.lastname: Lee
authors.forename: I-Chuan
authors.initials: IC
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Sun
authors.forename: Feng-Hsiang
authors.initials: FH
authors.lastname: Chiu
authors.forename: Chung-Hsun
authors.initials: CH
authors.lastname: Chuang
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology; D014527:Uric Acid; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D008055:Lipids; D014527:Uric Acid
keywords: hepatitis B; hepatitis C; insulin resistance; lipid metabolism; metabolic syndrome