title: Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity.
abstract: Understanding the metabolic factors that contribute to obesity development and weight loss success are critical for combating obesity and obesity-related disorders. This review provides an overview of energy metabolism with a particular focus on mitochondrial function in health and in obesity. Mitochondrial proton leak contributes significantly to whole body energy expenditure and the potential role of energy uncoupling in weight loss success is discussed. We provide evidence to support the hypothesis that differences in energy efficiency are important regulators of body weight and weight loss success.
authors.affiliation: Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada.
authors.forename: A Brianne
authors.initials: AB
authors.lastname: Thrush
authors.forename: Robert
authors.initials: R
authors.lastname: Dent
authors.forename: Ruth
authors.initials: R
authors.lastname: McPherson
authors.forename: Mary-Ellen
authors.initials: ME
authors.lastname: Harper
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology; D004734:Energy Metabolism; D015444:Exercise; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D010085:Oxidative Phosphorylation; D011522:Protons; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D011522:Protons
keywords: diet resistance; mitochondria; obesity; oxidative phosphorylation; proton leak; uncoupling; weight loss