title: Effect of diet and other factors on serum adiponectin concentrations in patients with type 2 diabetes.
abstract: BACKGROUND. Adiponectin is a protein specific to visceral adipose tissue where its concentrations are reduced in type 2 diabetes and obesity. Many factors also determine serum levels of adiponectin such as gender, BMI, as well as diet. OBJECTIVE. To compare the effects of consuming certain key foodstuffproducts on serum adiponectin concentrations between diabetic patients and suitable controls.
  
  
  METHODS
  A survey and laboratory testing was performed on 72 patients of whom (n = 21) were diabetics, whilst the control group, (n= 51) non-diabetics. Eating habits were assessed and serum adiponectin was measured in all cases.
  
  
  RESULTS
  Diabetic patients had significantly lower adiponectin levels compared to the control group; respectively (23.5 +/- 21.1 microg/ml vs. 36.5 +/- 21.1 microg/ml; p = 0.02). Furthermore, women had higher concentration than men; respectively (41.3 microg/ml +/- 20.1 microg/ml vs. 22.0 microg/ml +/- 14.8 microg/ml; p = 0.000). A high consumption of foodstuffs such as vegetables, vegetable oils, coffee and tea positively correlated with adiponectin concentration in serum, whilst a negative correlation was seen with consumptions of mixed bread, fried and baked dishes, alcohol, nuts and seeds.
  
  
  CONCLUSIONS
  Serum adiponectin levels are related to factors such as gender, (higher in women), BMI, (higher in persons with normal body weight) and whether diabetic, (lower in people with diabetes). Multiple correlations were observed between the consumption of foodstuff product groups and serum adiponectin concentration. It is thereby suggested, that adiponectin could have a significant role to play in the treatment and prevention of diabetes and obesity.
authors.affiliation: Department of Dietetics and Clinical Nutrition, Faculty of Health Sciences, Medical University in Białystok, Poland. lucyna@umb.edu.pl
authors.forename: Lucyna
authors.initials: L
authors.lastname: Ostrowska
authors.forename: Joanna
authors.initials: J
authors.lastname: Fiedorczuk
authors.forename: Edyta
authors.initials: E
authors.lastname: Adamska
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000428:Alcohol Drinking / Q000453:epidemiology; D015992:Body Mass Index; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D012016:Reference Values; D012737:Sex Factors
chemical_list: D052242:Adiponectin