title: Breakdown of the Debye polarization ansatz at protein-water interfaces.
abstract: The topographical and physico-chemical complexity of protein-water interfaces scales down to the sub-nanoscale range. At this level of confinement, we demonstrate that the dielectric structure of interfacial water entails a breakdown of the Debye ansatz that postulates the alignment of polarization with the protein electrostatic field. The tendencies to promote anomalous polarization are determined for each residue type and a particular kind of structural defect is shown to provide the predominant causal context.
authors.affiliation: Instituto Argentino de Matemática Alberto P. Calderón, CONICET (National Research Council), Saavedra 15, Buenos Aires 1083, Argentina. ariel@afinnovation.com
authors.forename: Ariel
authors.initials: A
authors.lastname: Fernández Stigliano
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry*; D055672:Static Electricity; D014867:Water / Q000737:chemistry*; D018909:src Homology Domains
chemical_list: D011506:Proteins; D014867:Water