title: [Hemiparesis and facial palsy caused by methotrexate].
abstract: Methotrexate used in the treatment of acute lymphocytic leukemia, can cause neurotoxicity, including a rare presentation with hemiparesis. We describe two teenagers, who during the implementation of the M phase of the protocol, suffered hemiparesis, facial paresis and dysarthria which quickly reversed. Leukemia involvement of the central nervous system and stroke, were ruled out. We briefly review the pathophysiology of methotrexate neurotoxicity, the characteristics of the focal paresis presentation and magnetic resonance image findings.
authors.affiliation: Servicio de Oncología Pediátrica, Departamento de Pediatría, Universidad Industrial de Santander, Servicio de Oncología Pediátrica Hospital Universitario de Santander, Bucaramanga, Colombia.
authors.forename: E
authors.initials: E
authors.lastname: Rueda Arenas
authors.forename: J
authors.initials: J
authors.lastname: García Corzo
authors.forename: L
authors.initials: L
authors.lastname: Franco Ospina
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002648:Child; D005158:Facial Paralysis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D010291:Paresis / Q000139:chemically induced*
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate
keywords: Hemiparesia; Hemiparesis; Methotrexate; Metotrexato; Neurotoxicidad; Neurotoxicity