title: Chemistry and pharmacology of 4-hydroxylonchocarpin: a review.
abstract: 4-hydroxylonchocarpin (LCP) or 2',4-dihydroxy-3',4'-(2,2-dimethylchromene) chalcone is a chalcone of the class flavonoid, with a molecular weight of 322 g/mol mostly isolated in the family Moraceae and Leguminosae. LCP was reported to have a variety of pharmacological activities such as antibacterial, antifungal, anticancer, anti-reverse transcriptase, antitubercular, antimalarial, anti-inflammatory, ornitnine decarboxylase activity and antioxidant. The hemisynthesis of the compound has been described. The present review was undertaken to bring out together the knowledge on LCP, and can serve as the start point for future research and valorization accomplishments.
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Dschang, Yaounde, Cameroon. kuetevictor@yahoo.fr
authors.forename: Victor
authors.initials: V
authors.lastname: Kuete
authors.forename: Jaures A K
authors.initials: JA
authors.lastname: Noumedem
authors.forename: Frederic
authors.initials: F
authors.lastname: Nana
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D053898:Biosynthetic Pathways / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D047309:Flavones / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans
chemical_list: C508226:4-hydroxylonchocarpin; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047309:Flavones