title: [Posterior reversible encephalopathy syndrome: 5 chemotherapy related cases].
abstract: Posterior reversible encephalopathy syndrome, previously known as Reversible posterior leukoencephalopathy syndrome, is a clinical-radiological condition characterized by headache, altered mental functioning, seizures and visual alterations, with the magnetic resonance imaging showing cerebral edema, predominantly in the white matter with posterior distribution. Multiple clinical conditions can act as triggers. We present five oncology patients, four of them with acute lymphoblastic leukemia, receiving chemotherapy when they presented with this pathology. A prompt diagnosis, an appropriate therapy for hypertension, and a rapid control of the seizures are the keys to avoiding sequelae.
authors.affiliation: Unidad de Oncohematología Infantil, Servicio de Pediatría, Complejo Hospitalario de Navarra B, Pamplona, España. Electronic address: i.sanmart@hotmail.com.
authors.forename: I
authors.initials: I
authors.lastname: San Martín García
authors.affiliation: Unidad de Oncohematología Infantil, Servicio de Pediatría, Complejo Hospitalario de Navarra B, Pamplona, España.
authors.forename: R
authors.initials: R
authors.lastname: Urabayen Alberdi
authors.affiliation: Unidad de Oncohematología Infantil, Servicio de Pediatría, Complejo Hospitalario de Navarra B, Pamplona, España.
authors.forename: V
authors.initials: V
authors.lastname: Díez Bayona
authors.affiliation: Unidad de Oncohematología Infantil, Servicio de Pediatría, Complejo Hospitalario de Navarra B, Pamplona, España.
authors.forename: M
authors.initials: M
authors.lastname: Sagaseta de Ilúrdoz Uranga
authors.affiliation: Unidad de Radiología Infantil, Servicio de Radiología, Complejo Hospitalario de Navarra B, Pamplona, España.
authors.forename: J
authors.initials: J
authors.lastname: Esparza Estaun
authors.affiliation: Unidad de Oncohematología Infantil, Servicio de Pediatría, Complejo Hospitalario de Navarra B, Pamplona, España.
authors.forename: J
authors.initials: J
authors.lastname: Molina Garicano
authors.affiliation: Servicio de Farmacología, Complejo Hospitalario de Navarra B, Pamplona, España.
authors.forename: S
authors.initials: S
authors.lastname: Berisa Prado
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapy; Edema cerebral vasogénico; Hipertensión; Hypertension; Magnetic resonance imaging; Quimioterapia; Resonancia magnética; Reversible posterior leukoencephalopathy syndrome; Síndrome de leuconcefalopatía posterior reversible; Vasogenic cerebral edema