title: Possible therapeutic targets among the molecules involved in the Warburg effect in tumor cells.
abstract: The majority of human tumors display a high rate of glycolysis under aerobic conditions. This phenomenon was recognized approximately seven decades ago and is known as the Warburg effect. Several key enzymes required to maintain this high level of glucose metabolism are found in tumor cells. The effects of the glycolytic enzymes are known to be directly or indirectly regulated by various signaling pathways, oncogenes, suppressor genes and transcription factors. Recent molecular biology studies have shown that multiple genetic alterations are related to tumor development. Therefore, these factors may be rational targets for cancer therapy. In this short review, we describe several important molecules that affect aerobic glycolysis and discuss their possible use as therapeutic targets for cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Sung Ouk
authors.initials: SO
authors.lastname: Nam
authors.forename: Fusanori
authors.initials: F
authors.lastname: Yotsumoto
authors.forename: Kohei
authors.initials: K
authors.lastname: Miyata
authors.forename: Naoto
authors.initials: N
authors.lastname: Shirasu
authors.forename: Shingo
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Masahide
authors.initials: M
authors.lastname: Kuroki
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006019:Glycolysis / Q000187:drug effects*; D006801:Humans; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors*; D009369:Neoplasms / Q000188:drug therapy*; D010100:Oxygen / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D010100:Oxygen
keywords: Glycolytic enzymes; Warburg effect; oncogenes; review; signaling pathways; transcription factors; tumor suppressor genes