title: Development and validation of HPTLC method for the determination of mycophenolate mofetil in bulk and pharmaceutical formulation.
abstract: OBJECTIVE
  Described in this manuscript is the first ever reported, new, simple, high-performance thin-layer chromatographic method for the determination of mycophenolate mofetil in bulk and tablet dosage form.
  
  
  METHODS
  The drug was separated on aluminum plates precoated with silica gel 60 F254 with toluene, acetone, and methanol in the ratio of 6:2:2 (v/v/v) as the mobile phase. Quantitative analysis was performed by densitometric scanning at 254 nm.
  
  
  RESULTS
  The method was validated for linearity, accuracy, precision, and robustness. The calibration plot was linear in the range of 100-500 ng band(-1) for mycophenolate mofetil. The method was successfully applied to the analysis of the drug in a pharmaceutical dosage form.
authors.affiliation: Department of Pharmaceutical analysis, Hindu College of Pharmacy, Amaravathi road, Guntur, A. P, India.
authors.forename: S
authors.initials: S
authors.lastname: Kathirvel
authors.forename: K Rajendra
authors.initials: KR
authors.lastname: Prasad
authors.forename: K Madhu
authors.initials: KM
authors.lastname: Babu
keywords: Accuracy; mycophenolate mofetil; tablet dosage form