title: 3D-printed devices for continuous-flow organic chemistry.
abstract: We present a study in which the versatility of 3D-printing is combined with the processing advantages of flow chemistry for the synthesis of organic compounds. Robust and inexpensive 3D-printed reactionware devices are easily connected using standard fittings resulting in complex, custom-made flow systems, including multiple reactors in a series with in-line, real-time analysis using an ATR-IR flow cell. As a proof of concept, we utilized two types of organic reactions, imine syntheses and imine reductions, to show how different reactor configurations and substrates give different products.
authors.affiliation: School of Chemistry, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK. Web: http://www.croninlab.com.
authors.forename: Vincenza
authors.initials: V
authors.lastname: Dragone
authors.forename: Victor
authors.initials: V
authors.lastname: Sans
authors.forename: Mali H
authors.initials: MH
authors.lastname: Rosnes
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Kitson
authors.forename: Leroy
authors.initials: L
authors.lastname: Cronin
keywords: 3D printing; flow IR; flow chemistry; imine reduction; imine synthesis; in-line analysis; millifluidics; reactionware