title: A case series of Nasopharyngeal Carcinoma among Indians, a low risk population, in Perak State, Malaysia.
abstract: Nasopharyngeal carcinoma (NPC) is rare among people of Indian ethnicity. A short retrospective case review of clinical records of Indian patients diagnosed with nasopharyngeal carcinoma in a period of 5 years was conducted. Their slides were further subjected to EBV encoded RNA (EBER) - In- situ Hybridization (ISH). The histologic subtype was nonkeratinizing carcinoma in all 4 patients. All were Epstein Barr Virus (EBV) positive. We believe that the crucial factor responsible for nasopharyngeal carcinoma is genetics; either a genetic susceptibility among high risk groups or genetic resistance/immunity in low risk groups. Further genetic studies are required to look for somatic or inherited chromosomal mutations among the various risk populations.
authors.affiliation: Hospital Raja Permaisuri Bainun, Ipoh, Perak, Malaysia. aansangel@yahoo.com.
authors.forename: B
authors.initials: B
authors.lastname: Anusha
authors.forename: R
authors.initials: R
authors.lastname: Philip
authors.forename: K
authors.initials: K
authors.lastname: Norain
authors.forename: S
authors.initials: S
authors.lastname: Harvinder
authors.forename: S M
authors.initials: SM
authors.lastname: Gurdeep
mesh_terms: D004854:Herpesvirus 4, Human; D006801:Humans; D017403:In Situ Hybridization; D008296:Malaysia; D012367:RNA, Viral; D012189:Retrospective Studies
chemical_list: D012367:RNA, Viral