title: Walking ability and quality of life in subjects with transfemoral amputation: a comparison of osseointegration with socket prostheses.
abstract: OBJECTIVE
  To investigate walking ability and quality of life of osseointegrated leg prostheses compared with socket prostheses.
  
  
  METHODS
  Prospective case-control study.
  
  
  METHODS
  University medical center.
  
  
  METHODS
  Subjects (N=22) with transfemoral amputation (1 bilateral) referred to our center because of socket-related skin and residual limb problems resulting in limited prosthesis use. Their mean age was 46.5 years (range, 23-67y) and mean time since amputation was 16.4 years (range, 2-45y). Causes of amputation were trauma (n=20) and tumor (n=2).
  
  
  METHODS
  Implantation of an osseointegration prosthesis (OIP).
  
  
  METHODS
  Global score of the Questionnaire for Persons With a Transfemoral Amputation (Q-TFA), prosthesis use, 6-minute walk test (6MWT), Timed Up & Go (TUG) test, and oxygen consumption during treadmill walking.
  
  
  RESULTS
  With the socket prosthesis, the mean ± SD Q-TFA global score, prosthesis use, 6MWT, TUG, and oxygen consumption were 39±4.7 points, 56±7.9h/wk, 321±28m, 15.1±2.1 seconds, and 1330±310mL/min, respectively, and significantly improved with OIP to 63±5.3 points, 101±2.4h/wk, 423±21m, 8.1±0.7 seconds, and 1093±361mL/min, respectively.
  
  
  CONCLUSIONS
  Osseointegration is a suitable intervention for persons whose prosthesis use is reduced because of socket-related problems. Subjects with OIP significantly increased their walking ability and prosthesis-related quality of life.
authors.affiliation: Department of Rehabilitation Medicine, Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence Based Practice, Nijmegen, The Netherlands. Electronic address: h.vandemeent@reval.umcn.nl.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Van de Meent
authors.forename: Maria T
authors.initials: MT
authors.lastname: Hopman
authors.forename: Jan Paul
authors.initials: JP
authors.lastname: Frölke
mesh_terms: D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D000674:Amputees / Q000534:rehabilitation*; D001186:Artificial Limbs; D016022:Case-Control Studies; D005260:Female; D005269:Femur / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D016348:Osseointegration; D010101:Oxygen Consumption; D011446:Prospective Studies; D011474:Prosthesis Design; D011788:Quality of Life; D016138:Walking; D055815:Young Adult
keywords: 6-minute walk test; 6MWT; Amputation; Function; Medical Outcomes Study 36-Item Short-Form Health Survey; OIP; OPRA; Osseointegrated Prosthesis for the Rehabilitation of Amputees; Osseointegration; PWS; Prosthesis; Q-TFA; Quality of life; Questionnaire for Persons With a Transfemoral Amputation; Rehabilitation; SF-36; TUG; Timed Up & Go; osseointegration prosthesis; preferred walking speed