title: Catalytic asymmetric hydrogenation of δ-ketoesters: highly efficient approach to chiral 1,5-diols.
abstract: High turnover: An highly efficient catalytic asymmetric hydrogenation of δ-aryl-δ-ketoesters has been realized by using the chiral spiroiridium catalyst (R)-1. Chiral 1,5-diol products are obtained with excellent enantioselectivity and turnover numbers (TONs) as high as 100,000. TOF = turnover frequency.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Yang
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xie
authors.forename: Wei-Peng
authors.initials: WP
authors.lastname: Liu
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou
keywords: asymmetric catalysis; catalyst design; hydrogenation; iridium; synthetic methods