title: [Atherogenic dyslipidemia in patients with type 1 diabetes mellitus].
abstract: OBJECTIVE
  To assess the prevalence of lipid abnormalities, with special emphasis on atherogenic dyslipidemia and its relationship with chronic complications in patients with type 1 diabetes mellitus (T1DM).
  
  
  METHODS
  Cross-sectional study including all patients aged 18 and over, diagnosed of T1DM attending the outpatient clinic at Hospital del Mar and Hospital de Granollers, in Barcelona, during 2008.
  
  
  RESULTS
  Of the 291 enrolled patients, 17.2 and 7.9% had high density lipoproteins (HDL) cholesterol<40 mg/dL (men) or<50mg/dL (women) and triglycerides>150 mg/dL, respectively. Hypoalphalipoproteinemic patients had a higher prevalence of peripheral neuropathy (28 vs. 7.1%, P<.001), macroalbuminuria (14 vs. 2.5%, P<.001) and higher concentrations of triglycerides (107.5 [55.8] vs. 82.7 [36] mg/dL, P<.0001) compared with those with normal/high HDL cholesterol levels. Hypertriglyceridemia was associated with increasing age (43.6 [11.2] vs. 37.6 [11.8] yr, P<.02), higher prevalence of hypertension (47.8 vs. 22.8%, P<.008), metabolic syndrome (82.6 vs. 22%, P<.001) and microangiopathic complications, lower insulin sensitivity (6.75 [2.1] vs. 8.54 [2.6] mg/Kg(-1)/min(-1), P<.004) compared with the normotriglyceridemic group.
  
  
  CONCLUSIONS
  One in 5 patients with T1DM has hypoalphalipoproteinemia or hypertriglyceridemia and these conditions are associated with 3 fold-increase microangiopathy. Thus, in these patients glycemic and blood pressure but also lipid profile control must be optimum.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital del Mar, Barcelona, España; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: JChillaron@parcdesalutmar.cat.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Chillarón
authors.forename: María P
authors.initials: MP
authors.lastname: Sales
authors.forename: Juana A
authors.initials: JA
authors.lastname: Flores Le-Roux
authors.forename: Ignasi
authors.initials: I
authors.lastname: Castells
authors.forename: David
authors.initials: D
authors.lastname: Benaiges
authors.forename: Enric
authors.initials: E
authors.lastname: Sagarra
authors.forename: Juan
authors.initials: J
authors.lastname: Pedro-Botet
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000209:etiology; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000453:epidemiology / Q000209:etiology*; D052456:Hypoalphalipoproteinemias / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
keywords: Alteraciones lipídicas; Atherogenic dyslipidemia; Complicaciones macrovasculares; Complicaciones microvasculares; Control metabólico; Diabetes tipo 1; Dislipidemia aterogénica; Lipid abnormalities; Macrovascular complications; Metabolic control; Microvascular complications; Type 1 diabetes