title: [Changes in MLS-BAEP in newborn piglets with hypoxic-ischemic brain damage during selective moderate head cooling therapy].
abstract: OBJECTIVE
  To study the effect of selective moderate head cooling therapy on maximum length sequences brainstem auditory evoked potential (MLS-BAEP) in newborn piglets with hypoxic-ischemic brain damage.
  
  
  METHODS
  Sixteen newborn piglets aged 5-7 day old were randomly divided into three groups: normothermic control (n=4), HI (n=6) and mild hypothermia-treated (n=6). HI was induced through temporary occlusion of both carotid arteries, followed by mechanical ventilation with low concentration of oxygen (FiO2=0.06) for 30 minutes. Mild hypothermia was induced by equipment via circulating water. MLS-BAER was recorded before HI and at 12 hours, 24 hours, 36 hours, 48 hours, 60 hours, 72 hours, 4 days, 7 days, 10 days, 13 days and 15 days after HI.
  
  
  RESULTS
  Compared with the normothermic control group, all latencies and intervals tended to increase significantly at 72 hours in the HI group and reached peak values on day 7. From day 10, all latencies and intervals tended to decrease, but apart from wave I latency, still differed significantly from those of the normothermic control group. MLS-BAER variables did not reach normal values until day 15. Ⅲ latency, Ⅰ-Ⅲ interval and Ⅰ-Ⅴ interval were significantly reduced in the hypothermia-treated group between 60 and 7 days after HI compared with the HI group (P<0.05). V latency and Ⅲ-Ⅴ interval in the hypothermia-treated group were also reduced compared with the HI group between 72 hours and 7 days after HI (P<0.05).
  
  
  CONCLUSIONS
  Both peripheral and central auditory systems are disturbed by HI, which shows as a significant increase in MLS-BAER variables (all latencies and intervals) in newborn piglets. Involvement in central brainstem auditory system reaches a peak on day 7 after injury. MLS-BAER variables still cannot reach to normal values until day 15. Selective moderate head cooling therapy can significantly reduce brainstem damage induced by HI.
authors.affiliation: Department of Neonatology, Gynecology and Obstetrics Hospital, Fudan University, Shanghai, China.
authors.forename: Ji-Mei
authors.initials: JM
authors.lastname: Wang
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Zhou
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Cheng
authors.forename: Lai-Shuang
authors.initials: LS
authors.lastname: Wang
authors.forename: Ze-Dong
authors.initials: ZD
authors.lastname: Jiang
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Shao
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D016057:Evoked Potentials, Auditory, Brain Stem; D007036:Hypothermia, Induced; D002534:Hypoxia, Brain / Q000503:physiopathology* / Q000628:therapy*; D013552:Swine