title: Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors.
authors.affiliation: Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China. tonyshing@cuhk.edu.hk
authors.forename: Tony K M
authors.initials: TK
authors.lastname: Shing
authors.forename: Wai-Lung
authors.initials: WL
authors.lastname: Ng
authors.forename: Judy Y-W
authors.initials: JY
authors.lastname: Chan
authors.forename: Clara B-S
authors.initials: CB
authors.lastname: Lau
mesh_terms: D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D051297:Sodium-Glucose Transporter 2 / Q000494:pharmacology; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013329:Structure-Activity Relationship
chemical_list: D005960:Glucosides; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; C516973:sergliflozin
keywords: SGLT2; allylation; antidiabetics; carbohydrate mimics; diastereoselectivity