title: Association between methylenetetrahydrofolate reductase C677T polymorphism and bone mineral density: the Dong-gu Study and the Namwon Study.
abstract: The purpose of this study was to examine the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and bone mineral density (BMD). Two large cohort studies were performed: the Dong-gu Study (3,621 men and 5,409 women) and the Namwon Study (3,703 men and 5,672 women). We assessed lumbar spine and femoral neck BMD by dual-energy X-ray absorptiometry. Genotypes were determined by real-time polymerase chain reaction. Multiple linear regression analysis was performed to evaluate the association between MTHFR C677T and BMD, adjusting for age, weight and height. The MTHFR C677T genotype frequencies for CC, CT, and TT genotypes were 34.5, 48.7, and 16.8%, respectively, in the Dong-gu Study and 33.6, 49.2, and 17.2%, respectively, in the Namwon Study. There are no significant differences between the MTHFR C677T genotype and the BMD at the lumbar spine and femoral neck in men or women in both cohorts.
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Rhee
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.forename: Hae-Sung
authors.initials: HS
authors.lastname: Nam
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Jeong
authors.forename: Kyeong-Soo
authors.initials: KS
authors.lastname: Park
authors.forename: Hye-Yeon
authors.initials: HY
authors.lastname: Kim
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Ryu
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Choi
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Song
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Kim
authors.forename: Jane A
authors.initials: JA
authors.lastname: Cauley
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000483:Alleles; D015519:Bone Density; D015331:Cohort Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Bone Density; Methylenetetrahydrofolate Reductase; Polymorphism, Genetic