title: The prevalence of presarcopenia in Asian Indian individuals with and without type 2 diabetes.
abstract: OBJECTIVE
  This study compared the skeletal muscle mass and prevalence of presarcopenia between Asian Indian individuals with and without type 2 diabetes.
  
  
  METHODS
  Participants with type 2 diabetes (n=76) and age- and sex-matched controls without diabetes (n=76) were drawn from the Chennai Urban Rural Epidemiological Study (CURES), which was carried out on a representative sample of Chennai City in South India. Skeletal muscle mass was estimated by dual-energy X-ray absorptiometry, and skeletal muscle mass index (SMI) was calculated by dividing the appendicular skeletal muscle mass by the square of the individual's height in meters and expressed as kg/m(2). Presarcopenia was defined as an SMI of ≤7.26 kg/m(2) for males and ≤5.5 kg/m(2) for females. Biochemical and anthropometric measurements were done using standardized procedures.
  
  
  RESULTS
  The 152 participants included 68 women (44.7%). Mean age was 44±9 years (range, 28-67 years), and the mean body mass index (BMI) was 25.7±3.8 kg/m(2). The prevalence rates of presarcopenia among individuals with and without diabetes were 39.5% and 15.8%, respectively (P=0.001). The mean SMI values were significantly lower in those with diabetes (6.84±1.02 kg/m(2)) compared with participants without diabetes (7.28±1.01 kg/m(2)) (P=0.009). SMI showed a positive correlation with BMI and waist circumference but a negative correlation with age, fasting plasma glucose, glycated hemoglobin, and low-density lipoprotien cholesterol in the total study population. Logistic regression analysis showed that diabetes was independently associated with presarcopenia (P=0.001).
  
  
  CONCLUSIONS
  Prevalence of presarcopenia is higher among Asian Indian subjects with type 2 diabetes compared with age- and sex-matched participants without diabetes.
authors.affiliation: Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India.
authors.forename: Viknesh Prabu
authors.initials: VP
authors.lastname: Anbalagan
authors.forename: Vijayachandrika
authors.initials: V
authors.lastname: Venkataraman
authors.forename: Rajendra
authors.initials: R
authors.lastname: Pradeepa
authors.forename: Mohan
authors.initials: M
authors.lastname: Deepa
authors.forename: Ranjit Mohan
authors.initials: RM
authors.lastname: Anjana
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D044466:Asian People; D001774:Blood Chemical Analysis; D001823:Body Composition; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology*; D004032:Diet; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D015995:Prevalence; D018401:Sample Size; D055948:Sarcopenia / Q000150:complications* / Q000453:epidemiology*; D012959:Socioeconomic Factors; D014505:Urban Population