title: Potential mechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on Sirtuins.
abstract: The development of atherosclerosis is a multi-step process, at least in part controlled by the vascular endothelium function. Observations in humans and experimental models of atherosclerosis have identified monocyte recruitment as an early event in atherogenesis. Chronic inflammation is associated with ageing and its related diseases (e.g., atherosclerosis and chronic obstructive pulmonary disease). Recently it has been discovered that Sirtuins (NAD+-dependent deacetylases) represent a pivotal regulator of longevity and health. They appear to have a prominent role in vascular biology and regulate aspects of age-dependent atherosclerosis. Many studies demonstrate that SIRT1 exhibits anti-inflammatory properties in vitro (e.g., fatty acid-induced inflammation), in vivo (e.g., atherosclerosis, sustainment of normal immune function in knock-out mice) and in clinical studies (e.g., patients with chronic obstructive pulmonary disease). Because of a significant reduction of SIRT1 in rodent lungs exposed to cigarette smoke and in lungs of patients with chronic obstructive pulmonary disease (COPD), activation of SIRT1 may be a potential target for chronic obstructive pulmonary disease therapy. We review the inflammatory mechanisms involved in COPD-CVD coexistence and the potential role of SIRT1 in the regulation of these systems.
authors.affiliation: Department of Medicine and Health Sciences, University of Molise, via Giovanni Paolo II - Loc. Tappino, 86100 Campobasso, Italy. viviana.turchiarelli@unimol.it.
authors.forename: Graziamaria
authors.initials: G
authors.lastname: Corbi
authors.forename: Andrea
authors.initials: A
authors.lastname: Bianco
authors.forename: Viviana
authors.initials: V
authors.lastname: Turchiarelli
authors.forename: Michele
authors.initials: M
authors.lastname: Cellurale
authors.forename: Federica
authors.initials: F
authors.lastname: Fatica
authors.forename: Aurora
authors.initials: A
authors.lastname: Daniele
authors.forename: Gennaro
authors.initials: G
authors.lastname: Mazzarella
authors.forename: Nicola
authors.initials: N
authors.lastname: Ferrara
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D037761:Sirtuins