title: Is anti-cyclic citrullinated Peptide antibody a good value biomarker for Alzheimer disease?
abstract: BACKGROUND
  Alzheimer's disease (AD) is one of the most important neurodegenerative disorder. Anti-cyclic citrullinated peptide (anti-CCP) may all be involved in the development of vascular disease such as AD. The aim of this study is detection of seropositivity for anti-CCP antibody in AD patients.
  
  
  METHODS
  In our study, 30 patients with AD and 29 healthy controls (age and-sex matched) were recruited. Homocysteine and anti-CCP was measured by spectrophotometrically and immunoassay.
  
  
  RESULTS
  Mean ± SE anti-CCP was higher significantly between AD (13.6 ± 3) and healthy subjects (4.8 ± 0.2) (P = 0.006). In the patients, anti-CCP serum level was in high range (32.1%) of abnormal levels, but there was no significant difference in serum homocysteine in AD patients compared with controls. There is no correlation between anti-CCP and homocysteine levels in AD patients (P = 0.75), but between age and anti-CCP level observed a significantly correlation (P = 0.04).
  
  
  CONCLUSIONS
  It needs more studies to clarify confirmation the role of anti-CCP antibody production in AD patients.
authors.affiliation: Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran.
authors.forename: Rokhsareh
authors.initials: R
authors.lastname: Meamar
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Askari
authors.forename: Majid
authors.initials: M
authors.lastname: Ghasemi
authors.forename: Mohammad Reza Aghaye
authors.initials: MR
authors.lastname: Ghazvini
authors.forename: Sahar
authors.initials: S
authors.lastname: Vesal
authors.forename: Mostafa
authors.initials: M
authors.lastname: Sharifkhah
authors.forename: Nazanin Alaei
authors.initials: NA
authors.lastname: Faradonbeh
authors.forename: Leila
authors.initials: L
authors.lastname: Dehghani
keywords: Alzheimer's disease; anti-cyclic citrullinated peptide; homocysteine