title: Effect of high LH/FSH ratio on women with polycystic ovary syndrome undergoing in vitro maturation treatment.
abstract: OBJECTIVE
  To determine whether high luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratios have a clinical impact on women with polycystic ovary syndrome (PCOS) undergoing in vitro maturation (IVM) treatment.
  
  
  METHODS
  Women with PCOS who underwent IVM treatment were divided into those with LH/FSH ratio > 1.5 and LH/FSH 0.5-1.5. We analyzed baseline characteristics of the patients, number of oocytes retrieved, number of mature oocytes, and pregnancy rates.
  
  
  RESULTS
  Women with LH/FSH ratio of > 1.5 had higher basal serum testosterone (2.2 vs. 1.4, p < 0.005, CI 0.1-1.0) and estradiol (188.7 +/- 16.2 vs. 143.7 +/- 6.9, p < 0.01, CI 23-96). The antral follicle count (AFC) was also higher in the patients with high LH/FSH (46.2 +/- 3.5 vs. 32.9 +/- 1.3, p < 0.001, CI 7-21). The total number of retrieved oocytes and number of mature oocytes was also significantly higher in women with LH/FSH ratio of > 1.5 than in those with a lower ratio. However, the pregnancy rate in women with LH/FSH ratio of > 1.5 (16.7%) was significantly lower than in those with a ratio of 0.5-1.5 (40.4%), p < 0.05, odds ratio 0.32.
  
  
  CONCLUSIONS
  PCOS patients with LH/FSH ratio of > 1.5 had higher basal testosterone, E2, and AFC but decreased pregnancy rate. This could be due to the deleterious effect of LH on folliculogenesis and endometrial receptivity.
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. amir.wiser@gmail.com
authors.forename: Amir
authors.initials: A
authors.lastname: Wiser
authors.forename: Fady
authors.initials: F
authors.lastname: Shehata
authors.forename: Hananel
authors.initials: H
authors.lastname: Holzer
authors.forename: Jordana H
authors.initials: JH
authors.lastname: Hyman
authors.forename: Einat
authors.initials: E
authors.lastname: Shalom-Paz
authors.forename: Weon-Young
authors.initials: WY
authors.lastname: Son
authors.forename: Togas
authors.initials: T
authors.lastname: Tulandi
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D004717:Endometrium / Q000503:physiopathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D009865:Oocytes / Q000254:growth & development*; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011247:Pregnancy; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone