title: A mild, one-pot Stadler-Ziegler synthesis of arylsulfides facilitated by photoredox catalysis in batch and continuous-flow.
abstract: Visible advance: A mild, one-pot Stadler-Ziegler process for C-S bond formation has been developed. The method employs the photoredox catalyst [Ru(bpy)3Cl2]⋅6 H2O irradiated with visible light. A variety of aryl-alkyl and diaryl sulfides were prepared from readily available arylamines and aryl/alkylthiols in good yields. The use of a photo microreactor led to a significant improvement with respect to safety and efficiency.
authors.affiliation: Harvard NeuroDiscovery Center, Harvard Medical School and Brigham & Women's Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA. xwang21@partners.org
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Cuny
authors.forename: Timothy
authors.initials: T
authors.lastname: Noël
mesh_terms: D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis*; D008027:Light; D015394:Molecular Structure; D055668:Photochemical Processes; D012428:Ruthenium / Q000737:chemistry*; D013440:Sulfides / Q000138:chemical synthesis*; D014867:Water
chemical_list: D006841:Hydrocarbons, Aromatic; D013440:Sulfides; D014867:Water; D012428:Ruthenium
keywords: CS bond formation; microflow chemistry; one-pot processes; visible-light photoredox catalysis