title: Controlled systemic release of therapeutic peptides from PEGylated prodrugs by serum proteases.
abstract: A novel concept to release peptidic drugs systemically by serum proteases from a PEGylated precursor makes it possible to tune release kinetics to fit the medical needs. Drug release depends on the size of the PEG polymer and the sequence and length of the peptide linker. The antimicrobial activities of the prodrugs were even better than those of the free peptides, whereas direct PEGylation abolished the peptide activity.
authors.affiliation: Institut für Bioanalytische Chemie, Zentrum für Biotechnologie und Biomedizin, Universität Leipzig, Deutscher Platz 5, 04103 Leipzig, Germany.
authors.forename: Friederike Inga
authors.initials: FI
authors.lastname: Nollmann
authors.forename: Tina
authors.initials: T
authors.lastname: Goldbach
authors.forename: Nicole
authors.initials: N
authors.lastname: Berthold
authors.forename: Ralf
authors.initials: R
authors.lastname: Hoffmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D051379:Mice; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism*
chemical_list: D023181:Antimicrobial Cationic Peptides; D011355:Prodrugs; C551620:oncocin; C061361:apidaecin; D011092:Polyethylene Glycols; D010447:Peptide Hydrolases
keywords: PEGylation; antimicrobial peptides; apidaecin; oncocin; prodrugs