title: [Experimental models of lysosomal phase reactivity in blood leukocytes exposed to low doses of potassium cyanide].
abstract: Cytochemical analysis of acid phosphatase was used to evaluate lysosomal membranes stability under oral intake of potassium cyanide by rats over one month in daily doses of 1.30 mg/kg (1/10 LD50) and 0.65 mg/kg (1/20 LD50). The authors demonstrated phase-related dose-dependent changes in the lysosomal state, and the main response feature was associated with functional activation that usually followed the membrane alteration.
authors.forename: M V
authors.initials: MV
authors.lastname: Dolgushin
authors.forename: G D
authors.initials: GD
authors.lastname: Khomuev
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D008247:Lysosomes / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D011041:Poisoning / Q000097:blood; D011190:Potassium Cyanide / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011190:Potassium Cyanide