title: Potential food-drug interactions in patients with rheumatoid arthritis.
abstract: Various medications are used for the treatment of rheumatoid arthritis (RA). Food-drug interactions may occur with concomitant ingestion of particular food. For example, methotrexate (MTX), the anchor drug in the therapeutic strategy against RA, is an antifolate agent. Excessive presence or absence of dietary folic acid may regulate MTX metabolism, possibly leading to unexpected adverse reactions. In this review, we focus on MTX, isoniazide and calcineurin inhibitors, and the implications of potential food-drug reactions in rheumatology, suggesting the important role of nutritional evaluations in RA patients.
authors.affiliation: Graduate School of Nutritional Science, Sagami Women's University, Kanagawa, Japan. k_msk@mac.com
authors.forename: Kayo
authors.initials: K
authors.lastname: Masuko
authors.forename: Shigeto
authors.initials: S
authors.lastname: Tohma
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Matsui
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000201:enzymology; D019703:Calcineurin / Q000378:metabolism; D065095:Calcineurin Inhibitors; D032083:Citrus paradisi; D004791:Enzyme Inhibitors / Q000009:adverse effects; D005492:Folic Acid / Q000009:adverse effects / Q000378:metabolism; D018565:Food-Drug Interactions; D005638:Fruit / Q000009:adverse effects; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects; D008727:Methotrexate / Q000009:adverse effects; D012307:Risk Factors; D017747:Seafood / Q000009:adverse effects
chemical_list: D018501:Antirheumatic Agents; D065095:Calcineurin Inhibitors; D004791:Enzyme Inhibitors; D005492:Folic Acid; D019703:Calcineurin; D007538:Isoniazid; D008727:Methotrexate