title: Clinico-pathologic relevance of Survivin splice variant expression in cancer.
abstract: Survivin is a member of the inhibitor of apoptosis (IAP) family and has multifunctional properties that include aspects of proliferation, invasion and cell survival control. Survivin is a promising candidate for targeted cancer therapy as its expression is associated with poor clinical outcome, more aggressive clinico-pathologic features, and resistance to radiation and chemotherapy. In the present review the different properties of the Survivin splice variants are discussed and their activities correlated with different aspects of cancer cell biology, to include subcellular location. Special emphasis is placed on our current understanding of these Survivin splice variants influence on each other and on the phenotypic responses to therapy that they may control.
authors.affiliation: Cancer Center & Department of Internal Medicine, Division of Hematology and Medical Oncology & Biospecimen Laboratory, Loma Linda University, Loma Linda, CA 92350, United States.
authors.forename: Rosalia de
authors.initials: Rd
authors.lastname: Necochea-Campion
authors.forename: Chien-Shing
authors.initials: CS
authors.lastname: Chen
authors.forename: Saied
authors.initials: S
authors.lastname: Mirshahidi
authors.forename: Frank D
authors.initials: FD
authors.lastname: Howard
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Wall
mesh_terms: D017398:Alternative Splicing; D002470:Cell Survival / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D042541:Intracellular Space / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D055503:Protein Multimerization; D021381:Protein Transport; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin
keywords: Cancer; Splice variants; Survivin