title: Viral evolution from one generation of human influenza infection to the next.
abstract: 1. In a sub-tropical epidemic, most of the apparent household secondary cases are actually secondary infections. 2. The consensus sequence for the entire influenza virus genome is not usually identical within the same household sample. Rather, there are commonly one or two nucleotide changes. 3. These results hint at an obvious generational threshold for adaptation at the level of the consensus sequence.
authors.affiliation: School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China. s.riley@imperial.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Riley
authors.forename: B J
authors.initials: BJ
authors.lastname: Cowling
authors.forename: K H
authors.initials: KH
authors.lastname: Chan
authors.forename: J S M
authors.initials: JS
authors.lastname: Peiris
authors.forename: G M
authors.initials: GM
authors.lastname: Leung
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D019143:Evolution, Molecular; D016679:Genome, Viral; D006801:Humans; D009980:Influenza A virus / Q000235:genetics* / Q000302:isolation & purification; D009981:Influenza B virus / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D009711:Nucleotides / Q000235:genetics; D010802:Phylogeny
chemical_list: D009711:Nucleotides