title: Comparing percutaneous coronary intervention and thrombolysis in patients with return of spontaneous circulation after cardiac arrest.
abstract: OBJECTIVE
  To evaluate the effects of percutaneous coronary intervention and thrombolysis after restoration of spontaneous circulation in cardiac arrest patients with ST-elevation myocardial infarction using meta-analysis.
  
  
  METHODS
  We performed a meta-analysis of clinical studies indexed in the PUBMED, MEDLINE and EMBASE databases and published between January 1995 and October 2012. In addition, we compared the hospital discharge and neurological recovery rates between the patients who received percutaneous coronary intervention and those who received thrombolysis.
  
  
  RESULTS
  Twenty-four studies evaluating the effects of percutaneous coronary intervention or thrombolysis after restoration of spontaneous circulation in cardiac arrest patients with ST-elevation myocardial infarction were included. Seventeen of the 24 studies were used in this meta-analysis. All studies were used to compare percutaneous coronary intervention and thrombolysis. The meta-analysis showed that the rate of hospital discharge improved with both percutaneous coronary intervention (p<0.001) and thrombolysis (p<0.001). We also found that cardiac arrest patients with ST-elevation myocardial infarction who received thrombolysis after restoration of spontaneous circulation did not have decreased hospital discharge (p = 0.543) or neurological recovery rates (p = 0.165) compared with those who received percutaneous coronary intervention.
  
  
  CONCLUSIONS
  In cardiac arrest patients with ST-elevation myocardial infarction who achieved restoration of spontaneous circulation, both percutaneous coronary intervention and thrombolysis improved the hospital discharge rate. Furthermore, there were no significant differences in the hospital discharge and neurological recovery rates between the percutaneous coronary intervention-treated group and the thrombolysis-treated group.
authors.affiliation: The First Affiliated Hospital of Sun Yat-sen University, Emergency Department, Guangzhou, People's Republic of China.
authors.forename: Ying-Qing
authors.initials: YQ
authors.lastname: Li
authors.forename: Shu-Jie
authors.initials: SJ
authors.lastname: Sun
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Hu
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Wei
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xiao-Xing
authors.initials: XX
authors.lastname: Liao
authors.forename: Xin
authors.initials: X
authors.lastname: Li
mesh_terms: D001775:Blood Circulation / Q000502:physiology*; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D005260:Female; D006323:Heart Arrest / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D010351:Patient Discharge; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D020127:Recovery of Function / Q000502:physiology; D015912:Thrombolytic Therapy / Q000379:methods*; D016896:Treatment Outcome