title: Distinct roles of Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factors in inflammatory response and cancer.
abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Similar to other herpesviruses, KSHV has two life cycles, latency and lytic replication. In latency, the KSHV genome persists as a circular episome in the nucleus of the host cell and only a few viral genes are expressed. In this review, we focus on oncogenic, antiapoptotic, and immunomodulating properties of KSHV-encoded homologues of cellular interferon regulatory factors (IRFs)--viral IRF1 (vIRF1) to vIRF4--and their possible role in the KSHV-mediated antiviral response, apoptosis, and oncogenicity.
authors.affiliation: Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: Petra
authors.initials: P
authors.lastname: Baresova
authors.forename: Paula M
authors.initials: PM
authors.lastname: Pitha
authors.forename: Barbora
authors.initials: B
authors.lastname: Lubyova
mesh_terms: D017209:Apoptosis; D063646:Carcinogenesis; D005814:Genes, Viral; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D007249:Inflammation / Q000209:etiology; D050835:Interferon Regulatory Factors / Q000235:genetics / Q000276:immunology*; D007372:Interferons / Q000378:metabolism; D008954:Models, Biological; D005810:Multigene Family; D015398:Signal Transduction; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*
chemical_list: D050835:Interferon Regulatory Factors; D014764:Viral Proteins; C413486:viral interferon regulatory factors; D007372:Interferons