title: Dietary supplementation with purified mulberry (Morus australis Poir) anthocyanins suppresses body weight gain in high-fat diet fed C57BL/6 mice.
abstract: We present our experiment about adding anthocyanins to the daily food of mice. Three kinds of anthocyanins (cyanidin-3-glucoside, cyanidin-3-rutinoside and pelargonidin-3-glucoside) purified from Chinese mulberry (Morus australis Poir) were evaluated for suppressing body weight gain of the male C57BL/6 mice fed with high-fat diet (HFD). The results from a 12-week experiment show that consumption of purified mulberry anthocyanins (MACN) of 40 or 200mg/kg can significantly inhibit body weight gain, reduce the resistance to insulin, lower the size of adipocytes, attenuate lipid accumulation and decrease the leptin secretion. Thus, dietary supplementation with MACN can protect against body weight gain of the diet-induced obese mice.
authors.affiliation: College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang 310058, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Xueming
authors.initials: X
authors.lastname: Qi
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.forename: Ruiyu
authors.initials: R
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zheng
authors.forename: Ting
authors.initials: T
authors.lastname: Yu
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage*; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements / Q000032:analysis*; D006801:Humans; D020738:Leptin / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D031625:Morus / Q000737:chemistry*; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D010936:Plant Extracts / Q000008:administration & dosage*; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D000872:Anthocyanins; D020738:Leptin; D010936:Plant Extracts