title: A phase 1 comparative pharmacokinetic and cardiac safety study of two intravenous formulations of CO-101 in patients with advanced solid tumors.
authors.affiliation: Division of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. r.stuurman@nki.nl
authors.forename: F E
authors.initials: FE
authors.lastname: Stuurman
authors.forename: M P
authors.initials: MP
authors.lastname: Lolkema
authors.forename: A D R
authors.initials: AD
authors.lastname: Huitema
authors.forename: P M M B
authors.initials: PM
authors.lastname: Soetekouw
authors.forename: H
authors.initials: H
authors.lastname: Rosing
authors.forename: L
authors.initials: L
authors.lastname: Rolfe
authors.forename: P
authors.initials: P
authors.lastname: Kaur
authors.forename: J H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: H
authors.initials: H
authors.lastname: van Tinteren
authors.forename: E E
authors.initials: EE
authors.lastname: Voest
authors.forename: J H M
authors.initials: JH
authors.lastname: Schellens
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D018592:Cross-Over Studies; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D013810:Therapeutic Equivalency; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; C538828:CP 4126; D003841:Deoxycytidine
keywords: CO-101; CP-4126; QT/QTc intervals; bioequivalence; cancer; dFdC; dFdU; formulation; gemcitabine; infusion; lipid; phase 1; phospholipids