title: [Permanence of last generation antiretroviral in daily clinical practice].
abstract: BACKGROUND
  Time of permanence is a useful measure of success in last generation antiretroviral (LGA) therapy: raltegravir, darunavir, etravirine and maraviroc. The aim of our study was to analyze the permanence of antiretroviral therapy (ART) containing at least one LGA, and to compare it with other ART used in experienced patients.
  
  
  METHODS
  Observational case-control study. It included adult outpatients whose ART was switched between 01/05/2008 and 01/09/2009. Cases (patients with at least one LGA) were matched (1:1) with pretreated patients who switched to an ART without any LGA (controls). The primary endpoint was the permanence of ART. The follow-up was conducted from the modification of ART to a year after the closure of the inclusion period. Results were adjusted for confounding variables: CD4 and viral load (VL) at baseline, MDR HIV infection and time from the first ART.
  
  
  RESULTS
  112 patients were included in each group. The permanence of ART was 16.7 months (cases) vs 16.8 months (controls), although statistically significant differences were not found after adjusting for confounding variables. Toxicity was the main reason of discontinuation (53.3% in cases vs 45.2% in controls, p = 0.70). The mean decrease in the logarithm of the VL was 0.89 in cases and 0.58 in controls (p = 0.223). The increase of CD4/microL was 77 and 73 respectively (p = 0.480).
  
  
  CONCLUSIONS
  The permanence of ART in patients whose treatment contains a LGA is similar to those without any LGA.
authors.forename: V
authors.initials: V
authors.lastname: Escudero Vilaplana
authors.forename: S
authors.initials: S
authors.lastname: Plata Paniagua
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez González
authors.forename: I
authors.initials: I
authors.lastname: Castillo Romera
authors.forename: A
authors.initials: A
authors.lastname: Ais Larisgoitia
authors.forename: M
authors.initials: M
authors.lastname: Sanjurjo Sáez
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D044966:Anti-Retroviral Agents