title: Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): an integrated multidisciplinary commentary.
abstract: Current therapeutic strategies against glioblastoma (GBM) have failed to prevent disease progression and recurrence effectively. The part played by molecular imaging (MI) in the development of novel therapies has gained increasing traction in recent years. For the first time, using expertise from an integrated multidisciplinary group of authors, herein we present a comprehensive evaluation of state-of-the-art GBM imaging and explore how advances facilitate the emergence of new treatment options. We propose a novel next-generation treatment paradigm based on the targeting of multiple hallmarks of cancer evolution that will heavily rely on MI.
authors.affiliation: Department of Physiology and Medical Physics & Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
authors.forename: Monika A
authors.initials: MA
authors.lastname: Jarzabek
authors.forename: Kieron J
authors.initials: KJ
authors.lastname: Sweeney
authors.forename: Rhys L
authors.initials: RL
authors.lastname: Evans
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Jacobs
authors.forename: Roger
authors.initials: R
authors.lastname: Stupp
authors.forename: Donncha
authors.initials: D
authors.lastname: O'Brien
authors.forename: Mitchel S
authors.initials: MS
authors.lastname: Berger
authors.forename: Jochen H M
authors.initials: JH
authors.lastname: Prehn
authors.forename: Annette T
authors.initials: AT
authors.lastname: Byrne
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D018450:Disease Progression; D005909:Glioblastoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control