title: Storable palladacycles for selective functionalization of alkyne-containing proteins.
abstract: We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Reyna K V
authors.initials: RK
authors.lastname: Lim
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003500:Cyclization; D008958:Models, Molecular; D010165:Palladium / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D000480:Alkynes; D011506:Proteins; D010165:Palladium