title: Use of methylene blue for treatment of severe sepsis in an immunosuppressed patient after liver transplantation.
abstract: Sepsis in the immunosuppressed patient is associated with very high mortality and morbidity. Treatment of sepsis in immunocompromised patients is especially challenging due to an unbalanced systemic inflammatory reaction with subsequent development of profound vasoplegia. Methylene blue (MB) has been successfully used for the treatment of refractory hypotension, but its use has not previously been reported for treatment of sepsis in immunosuppressed patients. The mechanism of MB's action is thought to be due to its inhibitory effect on cGMP-mediated vasodilatation. This case report describes the successful use of MB for treatment of severe septic shock in an immunosuppressed patient after liver transplantation. Hypotension in this patient was refractory to volume repletion and a combination of vasopressors. After MB administration, hemodynamic stability was rapidly reestablished. In the setting of severe sepsis in an immunosuppressed patient, MB should be considered early as a therapeutic option for treatment of refractory vasoplegia.
authors.affiliation: Department of Anesthesiology, Penn State Hershey Medical Center, 500 University Drive, H187 Hershey, PA 17033-0850, USA.
authors.forename: Saravanan
authors.initials: S
authors.lastname: Ramamoorthy
authors.forename: Shachi
authors.initials: S
authors.lastname: Patel
authors.forename: Eric
authors.initials: E
authors.lastname: Bradburn
authors.forename: Zakiyah
authors.initials: Z
authors.lastname: Kadry
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Uemura
authors.forename: Piotr
authors.initials: P
authors.lastname: K Janicki
authors.forename: Riaz Ali
authors.initials: RA
authors.lastname: Shah
authors.forename: Dmitri
authors.initials: D
authors.lastname: Bezinover