title: Predicting complex traits using a diffusion kernel on genetic markers with an application to dairy cattle and wheat data.
abstract: BACKGROUND
  Arguably, genotypes and phenotypes may be linked in functional forms that are not well addressed by the linear additive models that are standard in quantitative genetics. Therefore, developing statistical learning models for predicting phenotypic values from all available molecular information that are capable of capturing complex genetic network architectures is of great importance. Bayesian kernel ridge regression is a non-parametric prediction model proposed for this purpose. Its essence is to create a spatial distance-based relationship matrix called a kernel. Although the set of all single nucleotide polymorphism genotype configurations on which a model is built is finite, past research has mainly used a Gaussian kernel.
  
  
  RESULTS
  We sought to investigate the performance of a diffusion kernel, which was specifically developed to model discrete marker inputs, using Holstein cattle and wheat data. This kernel can be viewed as a discretization of the Gaussian kernel. The predictive ability of the diffusion kernel was similar to that of non-spatial distance-based additive genomic relationship kernels in the Holstein data, but outperformed the latter in the wheat data. However, the difference in performance between the diffusion and Gaussian kernels was negligible.
  
  
  CONCLUSIONS
  It is concluded that the ability of a diffusion kernel to capture the total genetic variance is not better than that of a Gaussian kernel, at least for these data. Although the diffusion kernel as a choice of basis function may have potential for use in whole-genome prediction, our results imply that embedding genetic markers into a non-Euclidean metric space has very small impact on prediction. Our results suggest that use of the black box Gaussian kernel is justified, given its connection to the diffusion kernel and its similar predictive performance.
authors.affiliation: Department of Animal Sciences, University of Wisconsin-Madison, Madison, WI, USA. morota@ansci.wisc.edu
authors.forename: Gota
authors.initials: G
authors.lastname: Morota
authors.forename: Masanori
authors.initials: M
authors.lastname: Koyama
authors.forename: Guilherme J M
authors.initials: GJ
authors.lastname: Rosa
authors.forename: Kent A
authors.initials: KA
authors.lastname: Weigel
authors.forename: Daniel
authors.initials: D
authors.lastname: Gianola
mesh_terms: D000465:Algorithms; D000818:Animals; D001499:Bayes Theorem; D002417:Cattle; D056726:Genetic Association Studies; D005819:Genetic Markers; D005838:Genotype; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D014908:Triticum / Q000235:genetics*
chemical_list: D005819:Genetic Markers