title: Diclofenac induced acute renal failure in a decompensated elderly patient.
abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed drugs in post-operative period worldwide. Their nephrotoxic effects are documented and accounts for around 15.5% of all cases of drug induced renal failure. Acute renal failure following NSAIDs usage are reported in volume depleted patients which is further precipitated by co-morbid conditions like hypertension and various drug interactions that increase plasma level of NSAIDs and worsens the condition. This highlights the importance of hydration in post-operative period as well as assessment of co-morbid conditions before administration of NSAIDs to prevent acute renal failure.
authors.affiliation: Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, Maharashtra, India.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Dhanvijay
authors.forename: Arup K
authors.initials: AK
authors.lastname: Misra
authors.forename: Sushil K
authors.initials: SK
authors.lastname: Varma
keywords: Drug interaction; hypertension; volume depleted