title: Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress.
abstract: Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS-induced oxidative stress.
authors.affiliation: Department of Biochemistry, School of Medicine, Keio University, Japan ; Division of Pulmonary Medicine, Department of Medicine, School of Medicine, Keio University, Japan ; Systems Glycobiology Research Group, Advanced Science Institute, RIKEN, Japan.
authors.forename: Rina
authors.initials: R
authors.lastname: Takamiya
authors.forename: Koichi
authors.initials: K
authors.lastname: Fukunaga
authors.forename: Makoto
authors.initials: M
authors.lastname: Arita
authors.forename: Jun
authors.initials: J
authors.lastname: Miyata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Seki
authors.forename: Naoto
authors.initials: N
authors.lastname: Minematsu
authors.forename: Makoto
authors.initials: M
authors.lastname: Suematsu
authors.forename: Koichiro
authors.initials: K
authors.lastname: Asano
keywords: COPD, chronic obstructive pulmonary disease; CS, cigarette smoke; CSE, cigarette smoke extract; Cigarette smoke; Macrophage; NOX2, NADPH oxidase2; ROS, reactive oxygen species; Reactive oxygen species; Resolvin E1; RvE1, Resolvin E1