title: Baseline Renal Function among Antiretroviral Therapy-Naive, HIV-Infected Patients in South East Nigeria.
abstract: Background:Renal insufficiency has been shown to be a significant, independent risk factor for mortality among HIV-infected patients. Unfortunately, little is known about the prevalence and nature of renal impairment in African populations initiating antiretroviral treatment. This study aims to find the prevalence of abnormal renal function among antiretroviral therapy (ART)-naive, HIV-infected patients in the South Eastern geopolitical zone of Nigeria.Method:This is a cross-sectional hospital-based study, involving 300 ART-naive HIV-positive patients, seen over a 1-year period, aged from 18 years and older, presenting to the clinic for the first time.Results:A total of 300 patients were included in the study, 104 (34.7%) males and 196 (65.3%) females. The prevalence of significant renal disease was 24.3% (73 of 300), while 38.3% (115 of 300) had mild renal impairment. Using logistic regression, age, CD4 count, urea, creatinine, and hemoglobin were significantly associated with renal impairment.Conclusion:The authors observed a high prevalence of significant renal impairment among HIV-infected patients at the time of ART initiation.
authors.affiliation: Department of medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu.
authors.forename: Obinna D
authors.initials: OD
authors.lastname: Onodugo
authors.forename: Chinwe
authors.initials: C
authors.lastname: Chukwuka
authors.forename: Cajetan
authors.initials: C
authors.lastname: Onyedum
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ejim
authors.forename: Anthony
authors.initials: A
authors.lastname: Mbah
authors.forename: Peter
authors.initials: P
authors.lastname: Nkwo
authors.forename: George
authors.initials: G
authors.lastname: Ugwu
authors.forename: Ubani
authors.initials: U
authors.lastname: Ukoma
authors.forename: Chinyere
authors.initials: C
authors.lastname: Okafor
authors.forename: Chukwujekwu
authors.initials: C
authors.lastname: Anyene
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Nwabueze
authors.forename: Frank
authors.initials: F
authors.lastname: Obi
authors.forename: Jude
authors.initials: J
authors.lastname: Akabueze
authors.forename: Ikenna
authors.initials: I
authors.lastname: Uche
authors.forename: Fintan
authors.initials: F
authors.lastname: Ekochin
authors.forename: Edith
authors.initials: E
authors.lastname: Nnoruka
keywords: HIV; baseline; kidney function