title: Pregnancy outcomes compared in women with mechanical heart valve replacements anticoagulated with warfarin and enoxaparin in pregnancy.
abstract: The anticoagulation of choice for mechanical heart valves is the oral anticoagulant warfarin. Warfarin is associated with increased risk of miscarriage, intrauterine fetal deaths and warfarin embryopathy. This longitudical cross-over study of 5 women observed all 5 having livebirths of healthy infants after heparin-managed pregnancies. Their earlier 8 pregnancies had all resulted in perinatal losses or miscarriages when on regimes based on warfarin.
authors.affiliation: Sabah Women & Children Hospital, Kota Kinabalu, Sabah, Malaysia. vj1vela@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Vijayan
authors.forename: T
authors.initials: T
authors.lastname: Rachel
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D018592:Cross-Over Studies; D017984:Enoxaparin; D005260:Female; D006350:Heart Valve Prosthesis; D006351:Heart Valves; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome; D014859:Warfarin
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D014859:Warfarin