title: Predictors of publication of randomized controlled trials in nephrology.
abstract: OBJECTIVE
  Changes in clinical practice based on research findings are dependent on the dissemination of information, which is a goal at national meetings. Given that evidence for many interventions in nephrology is lacking, it is important to determine predictors of publication of randomized controlled trials (RCTs) presented as abstracts at national conferences.
  
  
  METHODS
  All abstracts submitted to the American Society of Nephrology (ASN) meeting 2005 were reviewed to identify completed RCTs. Univariate logistic regression was used to compare characteristics between published RCTs until June 2010 and those not published. Time to publication was calculated.
  
  
  RESULTS
  73 completed RCTs were presented out of 4,280 abstracts. 53% of these were published; median time to publication was 24 months (13.36 IQR). Oral presentations were published more frequently (OR 3.66, p = 0.01) as well as those with stated industry funding (OR 2.92, p = 0.03) and larger sample sizes (OR 2.1, p = 0.01). Blinded RCTs had ~ 4 times the odds of being published. Only ten RCTs used clinical endpoints such as death, hospitalizations etc.; however, all reached publication.
  
  
  CONCLUSIONS
  Almost 50% of RCTs presented at the ASN 2005 meeting were not published within the studied time-frame. Well-conducted RCTs enhance the body of evidence needed to care for patients, if published. It is important to identify characteristics associated with non-publication, as above, to help us perform and report our studies better.
authors.forename: Ranjani N
authors.initials: RN
authors.lastname: Moorthi
authors.forename: Anna
authors.initials: A
authors.lastname: Lam
authors.forename: Navdeep
authors.initials: N
authors.lastname: Tangri
authors.forename: Manish M
authors.initials: MM
authors.lastname: Sood
authors.forename: Martin
authors.initials: M
authors.lastname: Wagner
authors.forename: Ahsan
authors.initials: A
authors.lastname: Alam
mesh_terms: D006801:Humans; D007674:Kidney Diseases / Q000628:therapy*; D009398:Nephrology; D010506:Periodicals as Topic / Q000706:statistics & numerical data; D011642:Publications / Q000706:statistics & numerical data*; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*