title: Age- and gender-related changes in ventricular performance in wild-type FVB/N mice as evaluated by conventional and vector velocity echocardiography imaging: a retrospective study.
abstract: Detailed studies in animal models to assess the importance of aging animals in cardiovascular research are rather scarce. The increase in mouse models used to study cardiovascular disease makes the establishment of physiologic aging parameters in myocardial function in both male and female mice critical. Forty-four FVB/N mice were studied at multiple time points between the ages of 3 and 16 mo using high-frequency echocardiography. Our study found that there is an age-dependent decrease in several systolic and diastolic function parameters in male mice, but not in female mice. This study establishes the physiologic age- and gender-related changes in myocardial function that occur in mice and can be measured with echocardiography. We report baseline values for traditional echocardiography and advanced echocardiographic techniques to measure discrete changes in cardiac function in the commonly employed FVB/N strain.
authors.affiliation: Internal Medicine, Division of Cardiology, University of Cincinnati, Cincinnati, Ohio, USA.
authors.forename: Sheryl E
authors.initials: SE
authors.lastname: Koch
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Haworth
authors.forename: Nathan
authors.initials: N
authors.lastname: Robbins
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Smith
authors.forename: Navneet
authors.initials: N
authors.lastname: Lather
authors.forename: Ahmad
authors.initials: A
authors.lastname: Anjak
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.forename: Priyanka
authors.initials: P
authors.lastname: Varma
authors.forename: W Keith
authors.initials: WK
authors.lastname: Jones
authors.forename: Jack
authors.initials: J
authors.lastname: Rubinstein
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004452:Echocardiography / Q000379:methods*; D055119:Elastic Modulus / Q000502:physiology; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D051379:Mice; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012727:Sex Characteristics; D013318:Stroke Volume / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Aging; Echocardiography; Gender; Myocardial function; Strain imaging