title: ROC trials update on prehospital hypertonic saline resuscitation in the aftermath of the US-Canadian trials.
abstract: The objectives of this review are to assess the current state of hypertonic saline as a prehospital resuscitation fluid in hypotensive trauma patients, particularly after the 3 major Resuscitation Outcomes Consortium trauma trials in the US and Canada were halted due to futility. Hemorrhage and traumatic brain injury are the leading causes of death in both military and civilian populations. Prehospital fluid resuscitation remains controversial in civilian trauma, but small-volume resuscitation with hypertonic fluids is of utility in military scenarios with prolonged or delayed evacuation times. A large body of pre-clinical and clinical literature has accumulated over the past 30 years on the hemodynamic and, most recently, the anti-inflammatory properties of hypertonic saline, alone or with dextran-70. This review assesses the current state of hypertonic fluid resuscitation in the aftermath of the failed Resuscitation Outcomes Consortium trials.
authors.affiliation: U.S. Army Institute of Surgical Research, San Antonio, TX, USA. michael.dubick@us.army.mil
authors.forename: Michael A
authors.initials: MA
authors.lastname: Dubick
authors.forename: Pang
authors.initials: P
authors.lastname: Shek
authors.forename: Charles E
authors.initials: CE
authors.lastname: Wade
mesh_terms: D001930:Brain Injuries / Q000628:therapy; D002170:Canada; D002986:Clinical Trials as Topic; D004632:Emergency Medical Services / Q000379:methods*; D006801:Humans; D012151:Resuscitation / Q000379:methods*; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000628:therapy; D014481:United States
chemical_list: D012462:Saline Solution, Hypertonic