title: Short-term effect of magnesium implantation on the osteomyelitis modeled animals induced by Staphylococcus aureus.
abstract: Pure magnesium (Mg) granules were implanted into the tibial medullary cavity of osteomyelitis modeled animals after debridement, and the animals without implant were taken as the control group. The antibacterial and osteogenic effects on bone tissue during Mg degradation were evaluated through detecting Mg ions, counting bacteria culture in peripheral blood, histology and iconography. The results showed that there was no significant difference for the concentration of serum Mg between the preoperative and postoperative animals within 5 weeks, maintaining in the normal range, and the number of bacteria in bone tissue of the Mg implant group was significantly lower than that of the control group. Mg implantation showed good biocompatibility no harmful to the liver, spleen, kidney and other organs in the modeled animals. In addition, the formation rate of new bone tissues around the implanted Mg was faster, indicating that the degradation of Mg could also promote the osteogenic process with good biocompatibility.
authors.affiliation: Department of Orthopedics, First Affiliated Hospital of Liaoning Medical University, No. 5-2, Renmin Street, Guta District, Jinzhou, 121000, China, kam995@163.com.
authors.forename: Jinhao
authors.initials: J
authors.lastname: Zeng
authors.forename: Ling
authors.initials: L
authors.lastname: Ren
authors.forename: Yajiang
authors.initials: Y
authors.lastname: Yuan
authors.forename: Yansong
authors.initials: Y
authors.lastname: Wang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Zhao
authors.forename: Ruming
authors.initials: R
authors.lastname: Zeng
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.forename: Xifan
authors.initials: X
authors.lastname: Mei
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry; D001842:Bone and Bones / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D008274:Magnesium / Q000737:chemistry*; D008297:Male; D010012:Osteogenesis; D010019:Osteomyelitis / Q000188:drug therapy*; D019736:Prostheses and Implants; D011817:Rabbits; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013977:Tibia / Q000473:pathology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D018786:Bone Substitutes; D008274:Magnesium