title: Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions: a study among patients with subcortical vascular cognitive impairment.
abstract: The relationship between the apolipoprotein E ε4 allele (APOE4) and factors associated with vascular cognitive impairment (VCI) is unclear. We aimed to examine the effects of APOE4 on brain amyloid beta using Pittsburg compound B (PiB) and subcortical cerebrovascular disease, as assessed by lacunes and white matter hyperintensities (WMH) in subcortical VCI (SVCI) patients. We recruited 230 subjects with normal cognition, 111 subjects with cognitive impairment due to clinically defined Alzheimer's disease (ADCI), and 134 subjects with clinically defined SVCI. A PiB retention ratio greater than 1.5 was considered to be PiB positive. Logistic regression analysis was performed to investigate whether APOE4 increased the risk for each cognitive impairment group. Multiple linear regression analysis was performed to investigate whether APOE4 was associated with brain amyloid beta, lacunes, and WMH. APOE4 did not increase the risk of PiB(-) SVCI (odds ratio [OR], 1.50; 95% confidence interval [CI], 0.79-2.84), whereas APOE4 increased the risk of PiB(+) SVCI (OR, 4.52; 95% CI, 1.70-11.97) and PiB(+) ADCI (odds ratio, 4.84; 95% CI, 2.54-7.91). In SVCI patients, APOE4 was positively associated with PiB retention ratio, whereas APOE4 was not associated with the number of lacunes or with WMH volume. Our results suggest that amyloid beta burden can occur in patients with and without subcortical cerebrovascular disease, and that it is associated with APOE4. However APOE4 might be independent of subcortical cerebrovascular disease.
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Byoung Seok
authors.initials: BS
authors.lastname: Ye
authors.forename: Cindy W
authors.initials: CW
authors.lastname: Yoon
authors.forename: Hanna
authors.initials: H
authors.lastname: Cho
authors.forename: Young
authors.initials: Y
authors.lastname: Noh
authors.forename: Geon Ha
authors.initials: GH
authors.lastname: Kim
authors.forename: Yae Seul
authors.initials: YS
authors.lastname: Choi
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Seun
authors.initials: S
authors.lastname: Jeon
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Kim
authors.forename: Yearn Seong
authors.initials: YS
authors.lastname: Choe
authors.forename: Kyung Han
authors.initials: KH
authors.lastname: Lee
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Changsoo
authors.initials: C
authors.lastname: Kim
authors.forename: Dae Ryong
authors.initials: DR
authors.lastname: Kang
authors.forename: Chang-Seok
authors.initials: CS
authors.lastname: Ki
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Lee
authors.forename: David J
authors.initials: DJ
authors.lastname: Werring
authors.forename: Michael W
authors.initials: MW
authors.lastname: Weiner
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D053327:Apolipoprotein E4 / Q000235:genetics / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D003072:Cognition Disorders / Q000150:complications / Q000473:pathology*; D005260:Female; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging; D013844:Thiazoles; D014652:Vascular Diseases / Q000150:complications / Q000473:pathology*
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D053327:Apolipoprotein E4; D013844:Thiazoles
keywords: APOE; Amyloid beta burden; Lacune; Subcortical vascular cognitive impairment; White matter hyperintensity