title: Enantioselective fluoroamination: 1,4-addition to conjugated dienes using anionic phase-transfer catalysis.
abstract: Chiral-anion phase-transfer catalysis (PTC) has been applied towards the enantioselective fluorocyclization reactions of 1,3-dienes. The method affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high yields and up to 96 % ee. New fluorinated amine reagents outperformed Selectfluor in the desired transformation.
authors.affiliation: Department of Chemistry, University of California-Berkeley, Latimer Hall, Berkeley, CA, USA.
authors.forename: Hunter P
authors.initials: HP
authors.lastname: Shunatona
authors.forename: Natalja
authors.initials: N
authors.lastname: Früh
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Wang
authors.forename: Vivek
authors.initials: V
authors.lastname: Rauniyar
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste
keywords: amination; asymmetric catalysis; cyclization; fluorine; phase-transfer catalysis