title: Preparation, characterization and antioxidant property of water-soluble ferulic acid grafted chitosan.
abstract: The objective of the present work was to improve the antioxidant activity and water solubility of chitosan by grafting with ferulic acid through a carbodiimide-mediated coupling reaction. UV-vis spectrophotometry, FTIR, (1)H NMR and ninhydrin assay confirmed the grafting of ferulic acid onto chitosan at the C-2 position. Ferulic acid grafted chitosan - prepared using a mole ratio of chitosan to ferulic acid of 1:1, reaction temperature of 60°C, and reaction time of 3h - possessed the highest ferulic acid substitution degree, i.e. 0.37. Although ferulic acid grafted chitosan showed reduced crystallinity (∼10%) and decreased decomposition temperature (∼55°C) as compared to chitosan, it exhibited greater radical scavenging activity (∼55%) and was soluble in water (up to 1.3mg/mL). The improved antioxidant property and water solubility of this chitosan derivative could open a wide range of applications, particularly its use as an antioxidant in food, food packaging, biomedical, pharmaceutical and cosmetics industries.
authors.affiliation: Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok 10900, Thailand.
authors.forename: Sarekha
authors.initials: S
authors.lastname: Woranuch
authors.forename: Rangrong
authors.initials: R
authors.lastname: Yoksan
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D003373:Coumaric Acids / Q000737:chemistry*; D058105:Polymerization; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D014867:Water; D048271:Chitosan; C004999:ferulic acid