title: Influenza vaccination and reduction in risk of ischemic heart disease among chronic obstructive pulmonary elderly.
abstract: COPD estimates the third leading cause of death by 2020. To reduce its complications becomes an important issue. The purpose of this study is to investigate the influenza vaccine effect for IHD occurrence with secondary to COPD. We used 11 years Taiwan National Health Insurance cohort research database and analyzed the relationships between vaccination and incident of IHD for COPD patients stratified by age. Total 29,178 COPD patients, 703 patients got vaccination out of 1464 who have developed IHD and 6010 patients vaccinated out of 27,714 that did not developed IHD. Major findings we observed: vaccination was associated with a reduced risk of IHD (OR, 0.746; 95% CI, 0.595-0.937) in elderly COPD patients. Influenza vaccination was associated with a reduced risk for IHD only in elderly COPD patients. Moreover, COPD patients with IHD had higher vaccination rate than without IHD.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taiwan. chenling@tmu.edu.tw
authors.forename: Chen-Ling
authors.initials: CL
authors.lastname: Huang
authors.forename: Phung Anh
authors.initials: PA
authors.lastname: Nguyen
authors.forename: Pih-lian
authors.initials: PL
authors.lastname: Kuo
authors.forename: Usman
authors.initials: U
authors.lastname: Iqbal
authors.forename: Yi-Hsin Elsa
authors.initials: YH
authors.lastname: Hsu
authors.forename: Wen-Shan
authors.initials: WS
authors.lastname: Jian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003199:Computer Systems; D003625:Data Collection; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000627:therapeutic use*; D007251:Influenza, Human / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology* / Q000517:prevention & control*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000628:therapy*; D012306:Risk; D012984:Software; D013624:Taiwan / Q000453:epidemiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007252:Influenza Vaccines
keywords: COPD (chronic obstructive pulmonary disease); Cohort research database; IHD (ischemic heart disease); Influenza vaccine; Vaccination