title: Alternative synthesis of P-chiral phosphonite-borane complexes: application to the synthesis of phostone-phostone dimers.
abstract: An improved strategy for the synthesis of P-chiral gluco- and manno-phosphonite-borane complexes is described on the basis of the addition of diethyl phosphonite-borane to a glucal-derived aldehyde, followed by a cyclization coupled with an ethyl/methyl exchange. This direct P(III) strategy facilitates the obtention of various P-chiral phosphonite-boranes, of which further coupling reactions are described leading to the selective synthesis of two phostone dimers.
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Angélique
authors.initials: A
authors.lastname: Ferry
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Malik
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.forename: Xavier
authors.initials: X
authors.lastname: Guinchard
authors.forename: David
authors.initials: D
authors.lastname: Crich
mesh_terms: D001880:Boranes / Q000737:chemistry*; D019281:Dimerization; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001880:Boranes; D009943:Organophosphorus Compounds