title: Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes.
abstract: This study evaluated the potential of circadian measures as early markers of mood disorders subtypes. Patients with bipolar disorders had significantly lower levels and later onset of melatonin secretion than those with unipolar depression. Furthermore, abnormal phase angles between sleep, melatonin and temperature were found in several patients.
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, 100, Mallett St, 2050 Camperdown, NSW, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Robillard
authors.forename: S L
authors.initials: SL
authors.lastname: Naismith
authors.forename: N L
authors.initials: NL
authors.lastname: Rogers
authors.forename: E M
authors.initials: EM
authors.lastname: Scott
authors.forename: T K C
authors.initials: TK
authors.lastname: Ip
authors.forename: D F
authors.initials: DF
authors.lastname: Hermens
authors.forename: I B
authors.initials: IB
authors.lastname: Hickie
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000378:metabolism / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology*; D003866:Depressive Disorder / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D027544:Salvia / Q000378:metabolism; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D008550:Melatonin
keywords: Actigraphy; Bipolar disorder; Circadian; Core body temperature; Depression; Melatonin