title: Aeruginosins from a Microcystis sp. bloom material collected in Varanasi, India.
abstract: Two novel biologically active short peptides, aeruginosins IN608 and IN652, were isolated from the cyanobacterium Microcystis sp. strain BHU006, which was collected from Durgakund water reservoir in Varanasi, India. Aeruginosins IN608 and IN652 are linear modified peptides containing four building blocks, one of which is the arogenate-derived modified amino acid 2-carboxy-6-hydroxyoctahydroindole. Aeruginosin IN608 and aeruginosin IN652 inhibit the activity of the proteolytic enzyme trypsin with IC50's of 4.3 and 4.1 μM, respectively.
authors.affiliation: Raymond and Beverly Sackler School of Chemistry and Faculty of Exact Sciences, Tel-Aviv University, Ramat Aviv, Tel-Aviv 69978, Israel.
authors.forename: Shira
authors.initials: S
authors.lastname: Elkobi-Peer
authors.forename: Rahul Kunwar
authors.initials: RK
authors.lastname: Singh
authors.forename: Tribhuban Mohan
authors.initials: TM
authors.lastname: Mohapatra
authors.forename: Shree Prakash
authors.initials: SP
authors.lastname: Tiwari
authors.forename: Shmuel
authors.initials: S
authors.lastname: Carmeli
mesh_terms: D007194:India; D020128:Inhibitory Concentration 50; D046931:Microcystis / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014881:Water Supply
chemical_list: D009842:Oligopeptides; D014361:Trypsin Inhibitors; C583933:aeruginosin IN608; C583932:aeruginosin IN652