title: Three rules for HIV latency: location, location, and location.
abstract: HIV latency is a major barrier to viral eradication from infected individuals. Lusic et al. (2013) show that HIV latency is established by spatially positioning the proviral chromatin in close proximity to promyelocytic leukemia (PML) nuclear bodies, a reversible process that recruits the methyltransferase enzyme G9a to the latent viral promoter.
authors.affiliation: Gladstone Institutes, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94941, USA. mott@gladstone.ucsf.edu
authors.forename: Melanie
authors.initials: M
authors.lastname: Ott
authors.forename: Eric
authors.initials: E
authors.lastname: Verdin
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D015967:Gene Expression Regulation, Viral; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism*; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D017735:Virus Latency
chemical_list: D009687:Nuclear Proteins; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C070576:PML protein, human