title: Successful port-a-cath salvage using linezolid in children with acute leukemia.
abstract: Central venous catheter (CVC) removal is indicated when persistent catheter-related bloodstream infection (CRBSI) occurs. This is a retrospective study to analyze the use of linezolid as a salvage therapy for CRBSIs due to coagulase-negative Staphylococci in children diagnosed with acute leukemia. Seven treatment courses of linezolid were administrated to six patients with port-type-CRBSI after non-effective intravenous vancomycin or teicoplanin treatment. Simultaneous lock and systemic therapy with linezolid avoided the removal of port-type-CVC in all cases. Treatment with linezolid was an alternative to catheter removal in these patients. Prospective studies are needed to confirm linezolid effectiveness as a salvage treatment in CRBSI.
authors.affiliation: Department of Pediatric Hematology, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain. rberrueco@hjsdbcn.org
authors.forename: Rubén B
authors.initials: RB
authors.lastname: Moreno
authors.forename: Susana
authors.initials: S
authors.lastname: Rives
authors.forename: Antonio
authors.initials: A
authors.lastname: Justicia
authors.forename: Albert
authors.initials: A
authors.lastname: Català
authors.forename: Anna
authors.initials: A
authors.lastname: Ruiz-Llobet
authors.forename: Teresa
authors.initials: T
authors.lastname: Toll
authors.forename: Jesús
authors.initials: J
authors.lastname: Estella
mesh_terms: D000081:Acetamides / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D062905:Central Venous Catheters; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D000069349:Linezolid; D008297:Male; D023303:Oxazolidinones / Q000008:administration & dosage*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D012189:Retrospective Studies; D016879:Salvage Therapy; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid
keywords: acute leukemia; catheter-related infections; children; linezolid