title: Heparin treatment for allergic conjunctivitis in the experimental BALB/c model.
abstract: OBJECTIVE
  To compare the inhibitory effects of dexamethasone and heparin on the infiltration of mast cells in the conjunctiva by using a mouse allergic conjunctivitis model.
  
  
  METHODS
  24 Balb/c mice were divided into four groups: allergy group (positive control), dexamethasone group, heparin group, and negative control group, as groups 1, 2, 3, and 4, respectively. Each group comprised 6 mice, and experimental allergic conjunctivitis was developed in groups 1, 2, and 3. The mice in group 2 were treated with topical 0.1% dexamethasone eye ointment, and the mice in group 3 were treated topically with 5,000 IU/ml standard heparin. Both dexamethasone and heparin were instilled once a day for 4 days. Hanks' balanced salt solution was dropped into both eyes of the mice in group 4 instead of dexamethasone or heparin. Eyeballs and eyelids were removed from the mice in all groups while one eye of each animal was used for histopathological, the other for molecular biological examination.
  
  
  RESULTS
  Mast cells, infiltrating the subconjunctival tissue, were significantly lower in group 2 (p < 0.0001), group 3 (p < 0.0001) and group 4 (p < 0.0001) when compared to group 1.
  
  
  CONCLUSIONS
  Topical heparin could be a viable option in treating IgE-induced allergic eye disease since it is found to be as effective as topical dexamethasone in experimental acute allergic eye disease.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey. tolgakocaturk@yahoo.com
authors.forename: T
authors.initials: T
authors.lastname: Kocatürk
authors.forename: O
authors.initials: O
authors.lastname: Kocatürk
authors.forename: A
authors.initials: A
authors.lastname: Kaplan
authors.forename: I
authors.initials: I
authors.lastname: Meteoğlu
authors.forename: H
authors.initials: H
authors.lastname: Cakmak
authors.forename: V
authors.initials: V
authors.lastname: Dayanir
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D003233:Conjunctivitis, Allergic / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D006493:Heparin / Q000627:therapeutic use*; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000925:Anticoagulants; D006493:Heparin