title: Chemotherapy induced hepatotoxicity in metastatic colorectal cancer: a review of mechanisms and outcomes.
abstract: Colorectal cancer remains one of the most common cancers worldwide. The treatment of metastatic disease has advanced considerably in the past 10 years both in terms of surgical technique and development of novel chemotherapeutic agents. The widespread use of multiple chemotherapeutic agents has lead to recognition of distinct patterns of hepatotoxicity associated with specific drugs. These side-effects have potential implications for both the patient and medical professional, but the underlying mechanisms involved in these conditions remains poorly understood. This review explores the mechanisms of action of the commonly used chemotherapeutic agents and the potential mechanisms for their hepatotoxicity. It is important that all medical professionals involved in the management of metastatic colorectal cancer understand the problems of hepatotoxicity and the impact they have on the patient.
authors.affiliation: MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, L69 3GE, United Kingdom; North Western Hepatobiliary Unit, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, United Kingdom. Electronic address: Derek.mcwhirter@liverpool.ac.uk.
authors.forename: Derek
authors.initials: D
authors.lastname: McWhirter
authors.forename: Neil
authors.initials: N
authors.lastname: Kitteringham
authors.forename: Robert P
authors.initials: RP
authors.lastname: Jones
authors.forename: Hassan
authors.initials: H
authors.lastname: Malik
authors.forename: Kevin
authors.initials: K
authors.lastname: Park
authors.forename: Daniel
authors.initials: D
authors.lastname: Palmer
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D009362:Neoplasm Metastasis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: Biomarkers; Chemotherapy; Colorectal cancer; Hepatotoxicity; Mechanisms; Metastatic