title: Gold-catalyzed sequential alkyne activation: one-pot synthesis of NH-carbazoles via cascade hydroarylation of alkyne/6-endo-dig carbocyclization reactions.
abstract: A simple and efficient one-pot protocol for the synthesis of NH-carbazoles has been described. The strategy comprises a one-pot reaction involving the treatment of 2-alkynyl indoles with arylacetylenes in the presence of an Au-Ag combination catalyst. The salient feature of the strategy involves sequential activation of terminal and internal alkynes leading to the cascade hydroarylation of terminal alkynes and 6-endo-dig carbocyclization reactions. The generality of the method has been demonstrated by using a series of 2-alkynyl indoles and arylacetylenes.
authors.affiliation: Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Samala
authors.forename: Anil K
authors.initials: AK
authors.lastname: Mandadapu
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saifuddin
authors.forename: Bijoy
authors.initials: B
authors.lastname: Kundu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D050607:Organogold Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D002227:Carbazoles; D050607:Organogold Compounds; D006046:Gold