title: Development and validation of UV-Visible spectrophotometric baseline manipulation methodology for simultaneous analysis of drotraverine and etoricoxib in pharmaceutical dosage forms.
abstract: BACKGROUND
  A simple, economical, precise, and accurate new UV spectrophotometric baseline manipulation methodology for simultaneous determination of drotaverine (DRT) and etoricoxib (ETR) in a combined tablet dosage form has been developed.
  
  
  METHODS
  The method is based on baseline manipulation (difference) spectroscopy where the amplitudes at 274 and 351 nm were selected to determine ETR and DRT, respectively, in combined formulation and methanol was used as solvent. Both the drugs obey Beer's law in the concentration ranges of 4-20 μg/mL for DRT and 4.5-22.5 μg/mL for ETR.
  
  
  RESULTS
  The results of analysis have been validated statistically and recovery studies confirmed the accuracy and reproducibility of the proposed method which were carried out by following the ICH guidelines.
  
  
  CONCLUSIONS
  It has been concluded that a new simple and accurate UV spectrophotometric baseline manipulation method was developed for simultaneous do not declare DRT and ETR in a combined tablet dosage form has been developed.
authors.affiliation: Department of Pharmaceutical Analysis and Quality Assurance, Maharashtra Institute of Pharmacy, Kothrud, Pune, India.
authors.forename: Vishnu P
authors.initials: VP
authors.lastname: Choudhari
authors.forename: Sanket R
authors.initials: SR
authors.lastname: Parekar
authors.forename: Subhash G
authors.initials: SG
authors.lastname: Chate
authors.forename: Pradeep D
authors.initials: PD
authors.lastname: Bharande
authors.forename: Bhanudas S
authors.initials: BS
authors.lastname: Kuchekar
keywords: Baseline manipulation (difference) spectroscopy; drotaverine; etoricoxib