title: Novel synthesis of substituted furo[3,2-c]chromen-4-ones via four-component reaction from substituted nitrostyrenes, aromatic aldehydes, coumarins, and ammonium acetate.
abstract: An efficient and direct synthesis of 2-arylideneamino-3-aryl-4H-furo[3,2-c]chromen-4-ones has been developed via four-component reaction from substituted nitrostyrenes, aromatic aldehydes, coumarins, and ammonium acetate under very mild conditions, which involves sequentially a Michael addition, an aza-nucleophilic addition, of the imine to the double bond, an intermolecular nucleophilic addition and a dehydration reaction. The resulting biologically intriguing structures could have broad applications in related biomedical-program structures.
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University , 180 Siwangting Street, Yangzhou 225002, Jiangsu, P. R. China.
authors.forename: Zhengquan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jinliang
authors.initials: J
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Yao
authors.forename: Cunde
authors.initials: C
authors.lastname: Wang
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry*; D003500:Cyclization; D013343:Styrenes / Q000737:chemistry*
chemical_list: D000085:Acetates; D000447:Aldehydes; D001578:Benzopyrans; D003374:Coumarins; D013343:Styrenes; C030123:coumarin; C018824:ammonium acetate