title: Susceptibility breakpoint for enrofloxacin against swine Salmonella spp.
abstract: Susceptibility breakpoints are crucial for prudent use of antimicrobials. This study has developed the first susceptibility breakpoint (MIC ≤ 0.25 μg/ml) for enrofloxacin against swine Salmonella spp. based on wild-type cutoff (COWT) and pharmacokinetic-pharmacodynamic (PK-PD) cutoff (COPD) values, consequently providing a criterion for susceptibility testing and clinical usage of enrofloxacin.
authors.affiliation: National Reference Laboratory of Veterinary Drug Residues/MOA Key Laboratory of the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.
authors.forename: Haihong
authors.initials: H
authors.lastname: Hao
authors.forename: Huafang
authors.initials: H
authors.lastname: Pan
authors.forename: Ijaz
authors.initials: I
authors.lastname: Ahmad
authors.forename: Guyue
authors.initials: G
authors.lastname: Cheng
authors.forename: Yulian
authors.initials: Y
authors.lastname: Wang
authors.forename: Menghong
authors.initials: M
authors.lastname: Dai
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Tao
authors.forename: Dongmei
authors.initials: D
authors.lastname: Chen
authors.forename: Dapeng
authors.initials: D
authors.lastname: Peng
authors.forename: Zhenli
authors.initials: Z
authors.lastname: Liu
authors.forename: Lingli
authors.initials: L
authors.lastname: Huang
authors.forename: Zonghui
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012475:Salmonella / Q000187:drug effects* / Q000302:isolation & purification; D012481:Salmonella Infections, Animal / Q000382:microbiology*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin