title: [Disseminated varicella-zoster virus infection with hemorrhagic gastritis during the course of chronic lymphocytic leukemia: case report and literature review].
abstract: BACKGROUND
  The reactivation of varicella-zoster virus occurs in immunocompromised patients, especially in cases of hematological malignancy. Disseminated reactivation could involve digestive tract with life-threatening condition.
  
  
  METHODS
  A 76-year-old woman, with a history of chronic lymphocytic leukemia, presented with left hypochondrium pain, and a vesicular rash with hemorrhagic shock that revealed an hemorrhagic gastritis due to varicella-zoster virus. The literature review identified 28 additional cases of gastrointestinal mucosal damage during reactivation of varicella-zoster virus. Mortality is 40%. We report here the first case in the course of low-grade lymphoid malignancy.
  
  
  CONCLUSIONS
  Acute gastrointestinal symptoms in immunocompromised patients should evoke a varicella-zoster virus reactivation with gastrointestinal involvement. This clinical manifestation, although rare, should not be ignored because of its severity.
authors.affiliation: Service de médecine interne, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Serris
authors.affiliation: Service de médecine interne, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France. Electronic address: jean-marie.michot@bct.aphp.fr.
authors.forename: J-M
authors.initials: JM
authors.lastname: Michot
authors.affiliation: Service de médecine interne, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Fourn
authors.affiliation: Service de médecine interne, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Le Bras
authors.affiliation: Service de médecine interne, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Dollat
authors.affiliation: Service de médecine interne, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Hirsch
authors.affiliation: Service de microbiologie et virologie, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Pallier
authors.affiliation: Service de gastro-entérologie, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Carbonnel
authors.affiliation: Service d'hématologie biologique, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Tertian
authors.affiliation: Service de médecine interne, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: O
authors.initials: O
authors.lastname: Lambotte
mesh_terms: D000368:Aged; D005260:Female; D005756:Gastritis / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D006471:Gastrointestinal Hemorrhage / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D006562:Herpes Zoster / Q000150:complications* / Q000175:diagnosis; D014645:Herpesvirus 3, Human / Q000502:physiology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D014775:Virus Activation
keywords: Chronic lymphocytic leukemia; Gastrointestinal hemorrhage; Hémorragie gastro-intestinale; Immunocompromised patient; Immunodéprimé; Leucémie lymphoïde chronique; Varicella-zoster virus; Virus varicelle-zona