title: Cohort profile: A prospective cohort study of objective physical and cognitive capability and visual health in an ageing population of men and women in Norfolk (EPIC-Norfolk 3).
abstract: The European Prospective Investigation of Cancer (EPIC) is a 10-country collaborative study in which EPIC-Norfolk is one of the UK centres. EPIC-Norfolk examined 25 639 men and women resident in East Anglia (aged 40-79 years), between 1993 and 1997. The EPIC collaboration was set up to examine the dietary determinants of cancer, but the remit in the EPIC-Norfolk cohort was broadened from the outset to include determinants of other health conditions and chronic diseases. EPIC-Norfolk completed a third round of health examinations (EPIC-Norfolk 3 or 3HC) in December 2011, on 8623 participants in the age range 48-92 years. EPIC-Norfolk focused on objective measures of cognitive function, physical capability and visual health, adapting this existing mid-life cohort to the current need to investigate healthy and independent living for ageing societies. With a wealth of longitudinal data and a biobank (including DNA) collected at up to three separate time points, EPIC-Norfolk offers the unique opportunity to investigate the association of lifestyle and biological factors, including genetic exposures, with a range of health outcomes in middle and later life. Information for data access can be found on the study website, details as given in this cohort profile.
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK Shabina.hayat@srl.cam.ac.uk.
authors.forename: Shabina A
authors.initials: SA
authors.lastname: Hayat
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Luben
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Keevil
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Moore
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Nichola
authors.initials: N
authors.lastname: Dalzell
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Amit
authors.initials: A
authors.lastname: Bhaniani
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Khawaja
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Foster
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Carol
authors.initials: C
authors.lastname: Brayne
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D003072:Cognition Disorders / Q000453:epidemiology*; D015331:Cohort Studies; D004739:England / Q000453:epidemiology; D005260:Female; D005901:Glaucoma / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D011446:Prospective Studies; D014786:Vision Disorders / Q000453:epidemiology*