title: Giant cell tumor of the larynx: a case of malignant sarcomatous transformation.
abstract: We report what is to the best of our knowledge the first case of malignant transformation of a giant cell tumor of the larynx. The patient, a 34-year-old man, presented to our tertiary care university teaching hospital where he underwent hemilaryngopharyngectomy with radial forearm free flap reconstruction and 11 of 15 cycles of chemotherapy. He remained disease-free at approximately 6 years and 4 months of follow-up. The patient is decannulated and continues to have a good voice with excellent quality of life to this day. We discuss the patient's clinical course and subsequent treatment within the context of a review of the current literature regarding this disease entity. Our experience demonstrates that giant cell tumor of the larynx may present as a malignant neoplasm without adversely affecting the patient's prognosis when treated aggressively with surgical resection and adjunct chemotherapy.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, UMHC Suite 4027, 1475 Northwest 12th Ave., Miami, FL 33136, USA. rvivero@gmail.com
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Vivero
authors.forename: Sandeep P
authors.initials: SP
authors.lastname: Dave
authors.forename: Carmen R
authors.initials: CR
authors.lastname: Gomez
authors.forename: Donald T
authors.initials: DT
authors.lastname: Weed
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic; D018212:Giant Cell Tumor of Bone / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D008297:Male