title: Synthesis of polysubstituted furans via copper-mediated annulation of alkyl ketones with α,β-unsaturated carboxylic acids.
abstract: A novel copper-mediated annulation of alkyl ketones with α,β-unsaturated carboxylic acids has been accomplished. This reaction provides a facile and regio-defined method for the synthesis of 2,3,5-trisubstituted furans from simple chemical reagents.
authors.affiliation: Department of Chemistry, ZJU-NHU United R&D Center, Zhejiang University, Hangzhou 310027, P. R. China.
authors.forename: Yuzhu
authors.initials: Y
authors.lastname: Yang
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Yao
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D002264:Carboxylic Acids; D005663:Furans; D007659:Ketones; D003300:Copper