title: Potential anti-angiogenic sulfates of andrographolide.
abstract: A new regioisomer of andrographolide, 17-hydro-9-dehydro-andrographolide (1), and five new sulfates of andrographolide (2-6) were isolated from Xiyanping, a China licensed anti-inflammatory drug derived from andrographolide through sulfation reaction. Their chemical structures were elucidated by spectroscopic and chemical methods. The inhibition effects of these compounds on angiogenesis were evaluated by rat aortic ring assay. Compounds 1 and 3 exhibited strong inhibitory activities on vascular endothelial cell tube formation in rat aorta ring at the concentration of 1 μM. Compounds 4 and 5 showed moderate suppression on angiogenesis at 10 μM.
authors.affiliation: a Jiangxi Provicial Institute for Drug and Food Control , Nanchang , 330029 , China.
authors.forename: Xiao-Wu
authors.initials: XW
authors.lastname: Xiao
authors.forename: Hui-Zheng
authors.initials: HZ
authors.lastname: Fu
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Luo
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Wei
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D013237:Stereoisomerism; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D020533:Angiogenesis Inhibitors; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D013463:Sulfuric Acid Esters; C030419:andrographolide