title: Odontoblasts in odontogenic tumors.
abstract: Odontoblasts are secretory cells displaying epithelial and mesenchymal features, which exist in a monolayer at the interface between the dentin and pulp of a tooth. During embryogenesis, these cells form a dentin shell and throughout life continue to produce dentin while, also acting as sensor cells helping to mediate tooth sensitivity. In this process, odontoblasts are forced to migrate inwards, resulting in an ongoing loss of pulp volume. Correspondingly, there is also a decrease in the surface area of the dentin which supports the odontoblast cell layer. As these events transpire, odontoblasts maintain a tightly controlled monolayer relationship to each other as well as to their dentin substrate. Stability is maintained laterally by epithelial attachment structures and transversely by complex cytoplasmic extensions into the supporting dentin. As a result, it is not possible for the layer to buckle to relieve the mechanical stresses, which develop during the inward migration. A theoretical consequence of this distinctive self-generated niche is the development of long term compressive stresses within the odontoblast population. We present a mechanobiology model, which causally relates the increase in cellular compressive stresses to contact inhibition of proliferation. We link this hypothesis to the observation that there are no reports of pulpal odontoblasts showing neoplasia or acquisition of changes suggestive of a pre-neoplastic phenotype.
authors.affiliation: School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Katz Group, Rexall Place, Edmonton, AB, Canada. nmilos@ualberta.ca
authors.forename: Nadine C
authors.initials: NC
authors.lastname: Milos
authors.forename: Edmund
authors.initials: E
authors.lastname: Peters
authors.forename: Tom
authors.initials: T
authors.lastname: Daley
mesh_terms: D001696:Biomechanical Phenomena; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D003804:Dentin / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009804:Odontoblasts / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D009808:Odontogenic Tumors / Q000503:physiopathology*; D013314:Stress, Mechanical