title: Rat hepatic and splanchnic vascular responses to anaphylactic shock, compared with hemorrhagic or vasodilator-induced shock.
abstract: BACKGROUND
  Hemodynamics during anaphylactic shock remain unclear. We determined hepatic and splanchnic responses to anaphylactic hypotension, compared with hemorrhage or sodium nitroprusside (SNP)-induced hypotension, in anesthetized rats.
  
  
  METHODS
  Portal pressure, systemic arterial pressure (SAP), central venous pressure, portal and hepatic arterial blood flow were measured. Splanchnic (Rspl), portal venous (Rpv), and hepatic arterial (Rha) resistances were determined.
  
  
  RESULTS
  In rats with anaphylaxis induced by an intravenous injection of the ovalbumin antigen (n=6), hemorrhage (n=6), and SNP (2 mg/kg, n=6), SAP decreased similarly. During anaphylaxis, Rha and Rspl decreased only at 30 s after the antigen injection. Notably, Rpv increased markedly. During hemorrhage, Rspl and Rha increased and decreased, respectively, with Rpv not changing. After SNP, Rha and Rspl decreased with Rpv not changing.
  
  
  CONCLUSIONS
  Hepatic and splanchnic vascular responses differ according to the type of shock. Anaphylactic hypotension is characterized by markedly increased portal venous resistance. Splanchnic and hepatic artery dilatation occurs only at the beginning of hypotension in anesthetized rats.
authors.affiliation: Department of Physiology II, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Toshishige
authors.initials: T
authors.lastname: Shibamoto
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanida
authors.forename: Mofei
authors.initials: M
authors.lastname: Wang
authors.forename: Lingling
authors.initials: L
authors.lastname: Sun
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Kurata
mesh_terms: D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D006439:Hemodynamics; D008102:Liver Circulation; D008297:Male; D051381:Rats; D012769:Shock / Q000139:chemically induced* / Q000503:physiopathology*; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013152:Splanchnic Circulation; D013997:Time Factors; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents
keywords: Anaphylaxis; circulatory shock; hemorrhage; hepatic circulation; rat model; sodium nitroprusside; splanchnic circulation