title: Effects of knee flexion on the femoropopliteal artery: a computational study.
abstract: During knee flexion, the muscles of the upper leg impose various loads on the underlying femoropopliteal artery resulting in radial compression, bending, torsion, axial extension and axial compression. Measuring the dynamic force environment of the femoropopliteal artery and quantifying its resulting deformation characteristics is an essential input to peripheral device design. The goal of this study was to create an anatomically accurate, three dimensional finite element model capable of capturing the loading conditions and deformation characteristics of the femoropopliteal artery during knee flexion. Three dimensional geometries of the muscle, bone, arterial and soft tissues of the leg were constructed from CT scan data and meshed for finite element analysis. Knee flexion was simulated and deformation characteristics of length change (axial compression), curvature, radial compression and axial twist were quantified and compared to previous experimental studies. The model predicts 8.23% shortening and an average curvature of 0.294±0.26 cm(-1) in the vessel after knee flexion, with maximum stresses of 61.17 kPa and maximum strains of 0.16%. The model created replicates known in vivo deformation characteristics seen previously in angiographic images and for the first time associates femoropopliteal artery deformation characteristics with stress and strain levels within the arterial tissue.
authors.affiliation: Mechanical and Biomedical Engineering, National University of Ireland, Galway, Ireland. Electronic address: riona.nighriallais@nuigalway.ie.
authors.forename: Ríona
authors.initials: R
authors.lastname: Ní Ghriallais
authors.forename: Mark
authors.initials: M
authors.lastname: Bruzzi
mesh_terms: D001696:Biomechanical Phenomena; D005263:Femoral Artery / Q000033:anatomy & histology; D020342:Finite Element Analysis; D006801:Humans; D007717:Knee / Q000033:anatomy & histology / Q000098:blood supply* / Q000502:physiology; D055595:Mechanical Phenomena; D009068:Movement; D009132:Muscles / Q000033:anatomy & histology / Q000502:physiology*
keywords: Femoral artery; In vivo loading; Peripheral vascular disease; Vessel curvature; Vessel deformation