title: In vitro bactericidal activity of photo-irradiated oxydol products via hydroxyl radical generation.
abstract: The oxidative power of hydroxyl radicals has been applied to disinfection systems for the purpose of oral hygiene by utilizing blue light-induced photolysis of hydrogen peroxide (H₂O₂) in our laboratory. In the present study, the bactericidal potential of blue light-irradiated oxydol products via hydroxyl radical generation was compared with that of 3% (w/v) H₂O₂. Eleven commercially available oxydol products were used in the present study. Even though a few of the products that contained ethanol, a hydroxyl radical scavenger, as an additive showed slightly lower hydroxyl radical yield as compared with 3% (w/v) H₂O₂, the blue-light irradiation of each oxydol product for 3 min showed similar or superior bactericidal activity against Staphylococcus aureus to that of 3% (w/v) H₂O₂. The results strongly suggest that any of the oxydol products tested in the present study can be used as a source of hydroxyl radicals for the disinfection technique developed in our laboratory.
authors.affiliation: Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Oyamada
authors.forename: Hiroyo
authors.initials: H
authors.lastname: Ikai
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nakamura
authors.forename: Eisei
authors.initials: E
authors.lastname: Hayashi
authors.forename: Taro
authors.initials: T
authors.lastname: Kanno
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sasaki
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Niwano
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry / Q000494:pharmacology*; D007834:Lasers; D008027:Light; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide