title: A novel 3α-p-Nitrobenzoylmultiflora-7:9(11)-diene-29-benzoate and two new triterpenoids from the seeds of zucchini (Cucurbita pepo L).
abstract: Three novel multiflorane-type triterpenoids, 3α-p-nitrobenzoylmultiflora-7:9(11)-diene-29-benzoate (1), 3α-acetoxymultiflora-7:9(11)-diene-29-benzoate (2), and 3α-acetoxymultiflora-5(6):7:9(11)-triene-29-benzoate (3), along with two known related compounds 4 and 5 were isolated from the seeds of zucchini (Cucurbita pepo L). Their structures were determined on the basis of 1D and 2D NMR spectroscopy and HREIMS. Triterpenoids possessing a nitro group were not isolated previously.
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. tanakar@gly.oups.ac.jp
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Saori
authors.initials: S
authors.lastname: Nakasuji
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ue
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shuto
authors.forename: Keishi
authors.initials: K
authors.lastname: Igarashi
authors.forename: Rina
authors.initials: R
authors.lastname: Okada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D028464:Cucurbita / Q000166:cytology / Q000378:metabolism*; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007941:Leukemia P388; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts; D012639:Seeds / Q000737:chemistry* / Q000166:cytology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C586208:3alpha-p-nitrobenzoylmultiflora-7:9(11)-diene-29-benzoate; D010936:Plant Extracts; D014315:Triterpenes