title: Achievement of 10-year survival: a case of pubic bone recurrence as the primary failure site of chemo-refractory ovarian clear cell carcinoma.
abstract: Clear cell carcinoma of the ovary tends to have a poor response to conventional platinum-based chemotherapy. Bone recurrence from ovarian cancer is rare and prognosis of patients with such a condition is poor. We report a patient with chemo-refractory ovarian clear cell carcinoma who developed pubic bone recurrence and subsequent para-aortic node recurrence. The patient achieved long-term survival after salvage surgery twice in spite of these inauspicious conditions. Surgical treatment should be taken into consideration for skeletal recurrence from ovarian clear cell carcinoma.
authors.affiliation: Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Sapporo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Akashi
authors.forename: Yukiharu
authors.initials: Y
authors.lastname: Todo
authors.forename: Kazuhira
authors.initials: K
authors.lastname: Okamoto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Minobe
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kato
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary / Q000601:surgery*; D002277:Carcinoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000532:radiotherapy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D011630:Pubic Bone; D012008:Recurrence; D016879:Salvage Therapy; D016896:Treatment Outcome
keywords: bone metastasis; clear cell carcinoma; long-term survival; ovarian cancer