title: Successful use of aromatase inhibitor letrozole in NOA with an elevated FSH level: a case report.
abstract: Aromatase inhibitors inhibit the conversion of testosterone to oestrogens and could reduce serum oestradiol concentrations. Letrozole is one of aromatase inhibitors frequently used in treatment of men with oligospermia. We present the case of an infertile man with small testes and an elevated FSH level, which was diagnosed as NOA, hypospermatogenesis proven by testicular biopsy. After taking letrozole for 3 months, semen analyses by computer-aided sperm analysis present that this man had normal spermatogenesis. This is the first case report of the activation of spermatogenesis, in man who was NOA with elevated FSH level, resulting from the use of the one of aromatase inhibitors.
authors.affiliation: Department of Urology, State Key Laboratory of Reproductive Medicine, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: D
authors.initials: D
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Pan
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: F
authors.initials: F
authors.lastname: Pan
authors.forename: J
authors.initials: J
authors.lastname: Ma
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy; D000077289:Letrozole; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D009845:Oligospermia / Q000188:drug therapy*; D013091:Spermatogenesis / Q000187:drug effects; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole; D005640:Follicle Stimulating Hormone
keywords: Aromatase inhibitors; letrozole; male infertility; nonobstructive azoospermia