title: Caesalpins A-H, bioactive cassane-type diterpenes from the seeds of Caesalpinia minax.
abstract: Eight new cassane-type diterpenes, caesalpins A-H (1-8), were isolated from the ethyl acetate extract of Caesalpinia minax. Compound 1 displayed significant antiproliferative activity against HepG-2 (IC50 4.7 μM) and MCF-7 (IC50 2.1 μM) cells, and compounds 2 and 4 exhibited selective cytotoxic activities against MCF-7 (IC50 7.9 μM) and AGS (IC50 6.5 μM) cells.
authors.affiliation: Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, People's Republic of China.
authors.forename: Guoxu
authors.initials: G
authors.lastname: Ma
authors.forename: Jingquan
authors.initials: J
authors.lastname: Yuan
authors.forename: Haifeng
authors.initials: H
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.forename: Xiaopo
authors.initials: X
authors.lastname: Zhang
authors.forename: Lijia
authors.initials: L
authors.lastname: Xu
authors.forename: Hua
authors.initials: H
authors.lastname: Wei
authors.forename: Lizhen
authors.initials: L
authors.lastname: Wu
authors.forename: Qingxia
authors.initials: Q
authors.lastname: Zheng
authors.forename: Liyong
authors.initials: L
authors.lastname: Li
authors.forename: Lijing
authors.initials: L
authors.lastname: Zhang
authors.forename: Junshan
authors.initials: J
authors.lastname: Yang
authors.forename: Xudong
authors.initials: X
authors.lastname: Xu
mesh_terms: D029911:Caesalpinia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005260:Female; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012639:Seeds / Q000737:chemistry
chemical_list: D004224:Diterpenes; D004365:Drugs, Chinese Herbal