title: Hydrophobic anticancer drug delivery by a 980 nm laser-driven photothermal vehicle for efficient synergistic therapy of cancer cells in vivo.
abstract: A novel 980 nm laser-driven hydrophobic anticancer drug-delivery platform based on hollow CuS nanoparticles is constructed in this work. The excellent synergistic therapy combining drug treatment and photothermal ablation of cancer cells both in vitro and in vivo is demonstrated, which opens up new opportunities for biological and medical applications.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Changchun, Jilin, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Dong
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Li
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002166:Camptothecin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D003300:Copper / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy; D013440:Sulfides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D013440:Sulfides; C099343:cuprous sulfide; D003300:Copper; D002166:Camptothecin
keywords: cancer therapy; drug delivery; hollow CuS nanoparticles; hydrophobic anticancer drug; synergistic therapy