title: Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy.
abstract: Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.
authors.affiliation: Department of Surgery, Division of Cardiothoracic Surgery, Alvin Siteman Cancer Center and Department of Pathology and Immunology Washington University School of Medicine.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Chang
authors.forename: Xue
authors.initials: X
authors.lastname: Lin
authors.forename: Ryuji
authors.initials: R
authors.lastname: Higashikubo
authors.forename: Kelsey
authors.initials: K
authors.lastname: Toth
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Gelman
authors.forename: Daniel
authors.initials: D
authors.lastname: Kreisel
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Krupnick
keywords: adoptive immune system; immunotherapy; lung cancer; mucosal antigen presentation; natural killer cells