title: Interactions between ADIPOQ gene variants and dietary monounsaturated: saturated fatty acid ratio on serum lipid levels in Korean children.
abstract: OBJECTIVE
  Adiponectin plays important roles in the regulation of insulin action and metabolism of glucose and lipids. We investigated whether ADIPOQ genetic variants are associated with serum lipid levels in Korean children and whether those influences might be modulated by dietary factors such as dietary monounsaturated fatty acid to saturated fatty acid ratio (MUFA:SFA).
  
  
  RESULTS
  The study included a population-based sample of 687 children aged 7-11 years in Gwacheon city, Kyunggi Province, Korea. Anthropometric and biochemical measurements and ADIPOQ genotype (-11377 C/G, +45 T/G, and +276 G/T) were determined. Dietary intake was estimated with a self reported 3-day food diary. The -11377 G allele carriers had significantly higher serum total cholesterol and LDL cholesterol compared to non-carriers. When dietary MUFA:SFA ratio was dichotomized (MUFA:SFA ≥ 1 or <1), the aggravating effects of the minor allele on serum total and LDL cholesterol were only present when the MUFA:SFA ratio was <1. Additionally, we observed that the ADIPOQ haplotype influenced serum total and LDL cholesterol levels. G-T-G haplotype carriers had higher total and LDL cholesterol levels than non-G-T-G carriers. The deleterious effect of ADIPOQ G-T-G haplotype to increase serum total and LDL cholesterol could be seen only when the MUFA:SFA ratio was <1.
  
  
  CONCLUSIONS
  In this present study, we found interaction effects between ADIPOQ genetic variants and dietary MUFA:SFA ratio on serum lipid levels in Korean children. These results suggest that individual genetic information and dietary fatty acid intake information should be assessed together to achieve an effective outcome for reducing the atherogenic lipid profile.
authors.affiliation: Division of Metabolic Diseases, Center for Biomedical Sciences, National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Republic of Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Park
authors.affiliation: Division of Metabolic Diseases, Center for Biomedical Sciences, National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Republic of Korea.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Division of Metabolic Diseases, Center for Biomedical Sciences, National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Republic of Korea.
authors.forename: H B
authors.initials: HB
authors.lastname: Jang
authors.affiliation: Center for Genome Science, National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Republic of Korea.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Hwang
authors.affiliation: Department of Family Medicine, Obesity Research Institute, Seoul Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Center for Genome Science, National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Republic of Korea.
authors.forename: B-G
authors.initials: BG
authors.lastname: Han
authors.affiliation: Center for Genome Science, National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Republic of Korea.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Division of Metabolic Diseases, Center for Biomedical Sciences, National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Republic of Korea. Electronic address: jhsong10@korea.kr.
authors.forename: J
authors.initials: J
authors.lastname: Song
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000483:Alleles; D044466:Asian People; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D015331:Cohort Studies; D004032:Diet; D002149:Energy Intake; D005227:Fatty Acids / Q000008:administration & dosage*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D015596:Nutrition Assessment; D011110:Polymorphism, Genetic; D056910:Republic of Korea; D014280:Triglycerides / Q000097:blood*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D014280:Triglycerides
keywords: ADIPOQ; Children; MUFA/SFA ratio; Serum lipid levels