title: Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review.
abstract: Ischemia/reperfusion (I/R) injury of the gut is a significant problem in a variety of clinical settings and is associated with a high morbidity and mortality. Although the mechanisms involved in the pathogenesis of gut I/R injury have not been fully elucidated, it is generally believed that oxidative stress with subsequent inflammatory injury plays an important role. Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, followed by production of CO, biliverdin, and free iron. The HO system is believed to confer cytoprotection by inhibiting inflammation, oxidation, and apoptosis, and maintaining microcirculation. HO-1, an inducible form of HO, serves a vital metabolic function as the rate-limiting step in the heme degradation pathway, and affords protection in models of intestinal I/R injury. HO-1 system is an important player in intestinal I/R injury condition, and may offer new targets for the management of this condition.
authors.affiliation: Department of Laboratory Medicine, Ningbo No. 2 Hospital, Ningbo 315010, Zhejiang Province, China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Liao
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Dong-Pei
authors.initials: DP
authors.lastname: Li
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D001664:Biliverdine / Q000378:metabolism; D002248:Carbon Monoxide / Q000378:metabolism; D006418:Heme / Q000378:metabolism; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D006801:Humans; D007422:Intestines / Q000098:blood supply* / Q000201:enzymology* / Q000473:pathology; D007501:Iron / Q000378:metabolism; D015427:Reperfusion Injury / Q000201:enzymology* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D006418:Heme; D002248:Carbon Monoxide; D007501:Iron; D051547:Heme Oxygenase-1; D001664:Biliverdine; D001663:Bilirubin
keywords: Cytoprotection; Gut; Heme oxygenase; Ischemia/reperfusion injury; Oxidative stress