title: Diabetes mellitus associated with clomipramine treatment: a retrospective analysis.
abstract: In this retrospective analysis, we analyzed all clinical record data in our Medical Division between January 2005 and December 2006 to evaluate an association between clomipramine treatment and glucose intolerance. Of 1997 patients, 154 (7.7%) had diabetes and 525 (26.3%) had depression. Diabetes prevalence was significantly higher in patients treated with clomipramine than in patients not treated [odds ratio 3.9, (2.2-7.0), p < 0.00001], independently by age and BMI. A possible causal role needs to be investigated in a prospective way.
authors.affiliation: Department of Internal Medicine, Ospedale Civile Livorno, viale Alfieri 36, 57100, Leghorn, Italy, nimumoli@tiscali.it.
authors.forename: Nicola
authors.initials: N
authors.lastname: Mumoli
authors.forename: Massimo
authors.initials: M
authors.lastname: Cocciolo
authors.forename: Josè
authors.initials: J
authors.lastname: Vitale
authors.forename: Marco
authors.initials: M
authors.lastname: Mantellassi
authors.forename: Silvia
authors.initials: S
authors.lastname: Sabatini
authors.forename: Lisa
authors.initials: L
authors.lastname: Gambaccini
authors.forename: Marco
authors.initials: M
authors.lastname: Cei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine