title: A target-induced fluorescent nanoparticle for in situ monitoring of Zn(II).
abstract: A target-induced fluorescent silica nanoparticle has been developed for the identification, enrichment and in situ determination of trace amounts of zinc(II). The nanoparticle combines the advantages of target-induced fluorescent compounds and the small size of the nanomaterial to produce a new, smarter nanosignaling material that is capable of selectively enriching a target and detecting a specific binding process in one step. As the target analyte, Zn(II), changes the fluorescence characteristics of the nanoparticle and effectively 'turns on' the fluorescence signal, no separation step is needed to confirm or quantify the binding process. The designed nanoparticle was characterized by several aspects prior to monitoring of Zn(II) in situ. The interferences from common metal ions were studied in detail. The photostability and reversibility of the sensing materials were investigated as well. The ability of this nanoparticle to detect the target Zn(II) provides a great advantage for in situ monitoring targets in biological samples under the fluorescence microscope.
authors.affiliation: Department of Chemistry, University of North Dakota, Grand Forks, North Dakota 58202, USA.
authors.forename: Carrie L
authors.initials: CL
authors.lastname: John
authors.forename: Yanfu
authors.initials: Y
authors.lastname: Huan
authors.forename: Xu
authors.initials: X
authors.lastname: Wu
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Jin
authors.forename: David T
authors.initials: DT
authors.lastname: Pierce
authors.forename: Julia Xiaojun
authors.initials: JX
authors.lastname: Zhao
mesh_terms: D000873:Anthracenes / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties; D015032:Zinc / Q000032:analysis* / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D005456:Fluorescent Dyes; D012822:Silicon Dioxide; C034020:anthracene; D015032:Zinc