title: In VitroActivity of Retapamulin against Staphylococcus aureus Resistant to Various Antimicrobial Agents.
abstract: Retapamulin and six other antimicrobial agents were evaluated against 155 methicillin-resistantStaphylococcus aureus(MRSA) isolates, including strains resistant to vancomycin, linezolid, daptomycin, and mupirocin by microdilution tests. Time-kill assays were performed against representative MRSA, vancomycin-intermediateS. aureus(VISA), and vancomycin-resistantS. aureus(VRSA) isolates. Retapamulin and mupirocin demonstrated MIC90s of 0.12 μg/ml and 8 μg/ml, respectively, with resistance seen in 2.6% and 10% of isolates, respectively. Retapamulin maintained good activity against 94% (15/16) of mupirocin-resistant isolates.
authors.affiliation: St. John Hospital and Medical Center and Wayne State University School of Medicine, Detroit, Michigan, USA louis.saravolatz@stjohn.org.
authors.forename: Louis D
authors.initials: LD
authors.lastname: Saravolatz
authors.affiliation: St. John Hospital and Medical Center and Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: Joan
authors.initials: J
authors.lastname: Pawlak
authors.affiliation: St. John Hospital and Medical Center and Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: Stephanie N
authors.initials: SN
authors.lastname: Saravolatz
authors.affiliation: St. John Hospital and Medical Center and Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: Leonard B
authors.initials: LB
authors.lastname: Johnson