title: Catalytic asymmetric hydrophosphonylation of ketimines.
abstract: Catalytic asymmetric hydrophosphonylation of aromatic and aliphatic N-thiophosphinoyl ketimines with dialkyl phosphite was efficiently promoted by as little as 0.5 mol% of catalyst loading at ambient temperature. The catalyst can be recovered for repeated use, and facile removal of the thiophosphinoyl group allowed for ready access to the phosphonic acid analogue of enantioenriched α,α-disubstituted α-amino acids.
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.
authors.forename: Liang
authors.initials: L
authors.lastname: Yin
authors.forename: Youmei
authors.initials: Y
authors.lastname: Bao
authors.forename: Naoya
authors.initials: N
authors.lastname: Kumagai
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D017905:Phosphites / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007097:Imines; D009570:Nitriles; D063065:Organophosphonates; D017905:Phosphites; C542835:ketimine