title: [The importance of stem cells in the initiation and development of cancer].
abstract: Initiation of cancer may be the result of mutations occurring in stem cells, which causes blocking the differentiation of these cells. Many common properties of the stem cells and some tumor cells suggests that cancer stem cells may be responsible for the initiation and progression of cancer. The special properties of CSC is the ability to self-renewal and cell proliferation, which are the major cause of cancer recurrence and metastasis. Signaling pathways (Wnt, Notch, Shh) and pluripotency- connected transcription factors (Oct-4, Nanog) are primarily responsible for cell proliferation. Understanding the causes of initiation and progression of cancer is crucial for improving treatment of these life-threatening diseases.
authors.affiliation: Pracowania Biochemii, Instytut Optoelektroniki, Wojskowa Akademia Techniczna, Warszawa, Poland. paulinapergol@wp.pl
authors.forename: Paulina
authors.initials: P
authors.lastname: Pergoł
authors.forename: Agata
authors.initials: A
authors.lastname: Nowak-Stepniowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Drela
authors.forename: Alfreda
authors.initials: A
authors.lastname: Padzik-Graczyk
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D018450:Disease Progression; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology*; D050814:Octamer Transcription Factor-3 / Q000378:metabolism; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D050814:Octamer Transcription Factor-3; D051153:Wnt Proteins