title: Mitomycin-C: 'a ray of hope' in refractory corrosive esophageal strictures.
abstract: Increasingly frequent dilation may become a self-defeating cycle in refractory stricture as recurrent trauma enhance, scar formation, and ultimately recurrence and potential worsening of the stricture. In 12 patients of caustic induced esophageal stricture, who failed to respond despite rigorous dilatation regimen for more than one year, a trial of topical mitomycin-C application to improve dilatation results was undertaken, considering the recently reported efficacy and safety of this agent. Mitomycin-C was applied for 2-3 minutes at the strictured esophageal segment after dilation with wire-guided Savary-Gilliard dilator. Patient was kept nil by mouth for 2-3 hours. After 4-6 sessions of mitomycin-C treatment, resolution of symptoms and significant improvement in dysphagia score and periodic dilatation index was seen in all 12 patients. Mitomycin-C topical application may be a useful strategy in refractory corrosive esophageal strictures and salvage patients from surgery.
authors.affiliation: Department of Gastroenterology, SMS Medical College Jaipur, Jaipur, India.
authors.forename: N
authors.initials: N
authors.lastname: Nagaich
authors.forename: S
authors.initials: S
authors.lastname: Nijhawan
authors.forename: P
authors.initials: P
authors.lastname: Katiyar
authors.forename: R
authors.initials: R
authors.lastname: Sharma
authors.forename: M
authors.initials: M
authors.lastname: Rathore
mesh_terms: D000287:Administration, Topical; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000150:complications; D003680:Deglutition Disorders / Q000209:etiology*; D004106:Dilatation / Q000295:instrumentation; D004940:Esophageal Stenosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D012720:Severity of Illness Index; D017211:Treatment Failure
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin
keywords: mitomycin-C; periodic dilation index (PDI); refractory stricture