title: Serum anti-Mullerian hormone levels in the main phenotypes of polycystic ovary syndrome.
abstract: OBJECTIVE
  To characterize the difference in circulating anti-Müllerian hormone (AMH) levels between the main polycystic ovary syndrome (PCOS) phenotypic groups and evaluate the role of AMH in predicting the severity of PCOS.
  
  
  METHODS
  Cross-sectional, retrospective study. A total of 251 women were divided into four groups based on the main features of PCOS, as follows: Group 1 (polycystic ovarian morphology [PCOM]+/oligo-anovulation [OA]+/hyperandrogenism [HA]+), Group 2 (PCOM+/OA+/HA-), Group 3 (PCOM+/OA-/HA+), and Group 4 (PCOM-/OA+/HA+). AMH and other hormone levels were measured in serum. The main outcome was serum AMH concentrations in the main phenotypes of PCOS.
  
  
  RESULTS
  The mean serum AMH levels were 9.50±6.1 ng/mL in Group 1; 8.02±6.2 ng/mL in Group 2; 6.12±3.6 ng/mL in Group 3; and 3.06±2.4 ng/mL in Group 4. Circulating AMH levels in Group 1 (PCOM+/OA+/HA+) were three times higher than those in Group 4 (PCOM-/OA+/HA+).
  
  
  CONCLUSIONS
  The highest AMH levels were found in cases where all three main diagnostic criteria existed. AMH levels correlate best with PCOM. In addition, oligo-anovulation contributes to increased AMH levels. Hyperandrogenism criteria were found to have less influence on AMH levels. AMH levels seem to have a diagnostic role in determining the severity of PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Electronic address: sahmay@yahoo.com.
authors.forename: Sezai
authors.initials: S
authors.lastname: Sahmay
authors.forename: Nil
authors.initials: N
authors.lastname: Atakul
authors.forename: Mahmut
authors.initials: M
authors.lastname: Oncul
authors.forename: Abdullah
authors.initials: A
authors.lastname: Tuten
authors.forename: Begum
authors.initials: B
authors.lastname: Aydogan
authors.forename: Hakan
authors.initials: H
authors.lastname: Seyisoglu
mesh_terms: D000328:Adult; D000858:Anovulation / Q000097:blood*; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood*; D010053:Ovary / Q000473:pathology; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000473:pathology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
keywords: AMH; Hyperandrogenism; Polycystic ovarian syndrome