title: The organization of the quorum sensing luxI/R family genes in Burkholderia.
abstract: Members of the Burkholderia genus of Proteobacteria are capable of living freely in the environment and can also colonize human, animal and plant hosts. Certain members are considered to be clinically important from both medical and veterinary perspectives and furthermore may be important modulators of the rhizosphere. Quorum sensing via N-acyl homoserine lactone signals (AHL QS) is present in almost all Burkholderia species and is thought to play important roles in lifestyle changes such as colonization and niche invasion. Here we present a census of AHL QS genes retrieved from public databases and indicate that the local arrangement (topology) of QS genes, their location within chromosomes and their gene neighborhoods show characteristic patterns that differ between the known Burkholderia clades. In sequence phylogenies, AHL QS genes seem to cluster according to the local gene topology rather than according to the species, which suggests that the basic topology types were present prior to the appearance of current Burkholderia species. The data are available at http://net.icgeb.org/burkholderia/.
authors.affiliation: International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, Trieste 32149, Italy. venturi@icgeb.org.
authors.forename: Kumari Sonal
authors.initials: KS
authors.lastname: Choudhary
authors.forename: Sanjarbek
authors.initials: S
authors.lastname: Hudaiberdiev
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Gelencsér
authors.forename: Bruna
authors.initials: B
authors.lastname: Gonçalves Coutinho
authors.forename: Vittorio
authors.initials: V
authors.lastname: Venturi
authors.forename: Sándor
authors.initials: S
authors.lastname: Pongor
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D019117:Burkholderia / Q000235:genetics*; D005798:Genes, Bacterial; D006801:Humans; D053038:Quorum Sensing / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; C085427:LuxI protein, Bacteria; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C064778:LuxR autoinducer binding proteins