title: Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine.
abstract: To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-146a, miR-196a2, miR-27a, miR-26a-1, miR-124 and miR-149 genes are associated with immune response to hepatitis B vaccine. The genotype and allele frequencies of SNPs were compared between the non-responders (n=77) and responders (n=207). The associations of the genotypes with antibody levels were assessed in the responders. Significant associations were observed between SNPs in miR-146a and miR-26a-1 genes and non-response to hepatitis B vaccine (p<0.05). In addition, SNPs in miR-146a and miR-27a genes were associated with variations in levels of antibodies to hepatitis B antigen. Thus, specific SNPs in microRNAs (miRNAs) genes may affect status of the hepatitis B vaccine induced protective humoral immune response. They also suggest that the three miRNAs play a role in modulating antibody responses to hepatitis B vaccine.
authors.affiliation: School Clinic; Guangdong Medical College; Dongguan, P.R. China.
authors.forename: Yongzhen
authors.initials: Y
authors.lastname: Xiong
authors.forename: Shengli
authors.initials: S
authors.lastname: Chen
authors.forename: Ruhong
authors.initials: R
authors.lastname: Chen
authors.forename: Weiyan
authors.initials: W
authors.lastname: Lin
authors.forename: Jindong
authors.initials: J
authors.lastname: Ni
mesh_terms: D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D035683:MicroRNAs
keywords: antibody; hepatitis B vaccine; immune response; miRNA; polymorphisms