title: Corticosteroids in peritonsillar abscess treatment: a blinded placebo-controlled clinical trial.
abstract: OBJECTIVE
  Sore throat is a common, benign emergency department (ED) presentation; however, peritonsillar abscess (PTA) is a complication that requires aggressive management. Use of systemic corticosteroids (SCSs) in PTA is occurring without clear evidence of benefit. This study examined the efficacy and safety of SCS treatment for patients with PTA.
  
  
  METHODS
  Randomized, double-blind, placebo-controlled trial.
  
  
  METHODS
  A controlled trial with concealed allocation and double-blinding was conducted at two Canadian EDs. Following written informed consent, eligible patients received 48 hours of intravenous clindamycin and a single dose of the study drug (dexamethasone [DEX] or placebo [PLAC], intravenously [IV]). Follow-up occurred at 24 hours, 48 hours, and 7 days. The primary outcome was pain; other outcomes were side effects and return to normal activities/diet.
  
  
  RESULTS
  A total of 182 patients were screened for eligibility; 41 patients were enrolled (21 DEX; 20 PLAC). At 24 hours, those receiving DEX reported lower pain scores (1.4 vs. 5.1; P = .009); however, these differences disappeared by 48 hours (P = .22) and 7 days (P = .4). At 24 hours, more patients receiving DEX returned to normal activities (33% vs. 11%) and dietary intake (38% vs 25%); however, these differences were not significant and disappeared by 48 hours and 7 days. Side effects were rare and did not differ between groups (P > .05).
  
  
  CONCLUSIONS
  Combined with PTA drainage and IV antibiotics, 10 mg IV DEX resulted in less pain at 24 hours when compared to PLAC, without any serious side effects. This effect is short-lived, and further research is required on factors associated with PTA treatment success.
authors.affiliation: Department of Otolaryngology, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Jason K M
authors.initials: JK
authors.lastname: Chau
authors.forename: Hadi R
authors.initials: HR
authors.lastname: Seikaly
authors.forename: Jeffery R
authors.initials: JR
authors.lastname: Harris
authors.forename: Cristina
authors.initials: C
authors.lastname: Villa-Roel
authors.forename: Craig
authors.initials: C
authors.lastname: Brick
authors.forename: Brian H
authors.initials: BH
authors.lastname: Rowe
mesh_terms: D000328:Adult; D003907:Dexamethasone / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D000039:Peritonsillar Abscess / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone
keywords: Peritonsillar abscess; corticosteroids; randomized controlled trial; relapse; sore throat