title: Developmentally programmed cell death in Drosophila.
abstract: During the development of metazoans, programmed cell death (PCD) is essential for tissue patterning, removal of unwanted cells and maintaining homeostasis. In the past 20 years Drosophila melanogaster has been one of the systems of choice for studies involving developmental cell death, providing an ideal genetically tractable model of intermediary complexity between Caenorhabditis elegans and mammals. The lessons learned from studies using Drosophila indicate both the conserved nature of the many cell death pathways as well as novel and unexpected mechanisms. In this article we review the understanding of PCD during Drosophila development, highlighting the key mechanisms that are evolutionarily conserved as well as apparently unusual pathways, which indicate divergence, but provide evidence of complexity acquired during organismic evolution. This article is part of a Special Section entitled: Cell Death Pathways.
authors.affiliation: Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, SA 5000, Australia; School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia; Division of Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.
authors.forename: Donna
authors.initials: D
authors.lastname: Denton
authors.affiliation: Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, SA 5000, Australia.
authors.forename: May T
authors.initials: MT
authors.lastname: Aung-Htut
authors.affiliation: Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, SA 5000, Australia; School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia; Department of Medicine, University of Adelaide, Adelaide, SA 5005, Australia; Division of Health Sciences, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: Sharad.Kumar@health.sa.gov.au.
authors.forename: Sharad
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000818:Animals; D017209:Apoptosis; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology* / Q000254:growth & development*; D008675:Metamorphosis, Biological; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins
keywords: Apoptosis; Autophagy; Caspases; Development; Drosophila; Programmed cell death