title: Isopalhinine A, a unique pentacyclic Lycopodium alkaloid from Palhinhaea cernua.
abstract: A new pentacyclic (5/6/6/6/7) Lycopodium alkaloid named isopalhinine A (1), which possesses a sterically congested architecture built with a tricyclo[4.3.1.0(3,7)]decane (isotwistane) moiety and a 1-azabicyclo[4.3.1]decane moiety, and palhinines B (2) and C (3) were isolated from Palhinhaea cernua. The structure and absolute configuration of 1 were elucidated by a combination of NMR spectra, optical rotation calculation, and X-ray diffraction experiment. A possible biogenetic pathway was also proposed.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Liao-Bin
authors.initials: LB
authors.lastname: Dong
authors.forename: Xiu
authors.initials: X
authors.lastname: Gao
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D029542:Lycopodiaceae / Q000737:chemistry*; D032502:Lycopodium / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D053978:Pentacyclic Triterpenes / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000470:Alkaloids; D053978:Pentacyclic Triterpenes; C585991:isopalhinine A