title: Multicomponent synthesis of 1-aryl 1,2,4-triazoles.
abstract: A multicomponent (single reactor) process for the synthesis of 1-aryl 1,2,4-triazoles was explored and developed. This transformation prepared the 1,2,4-triazole directly from anilines, amino pyridines, and pyrimidines. The reaction scope was explored with 21 different substrates, and the position of the nitrogen atoms in the newly formed ring was established by (15)N labeling and NMR spectroscopy.
authors.affiliation: Chemical Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, USA.
authors.forename: Annie
authors.initials: A
authors.lastname: Tam
authors.forename: Ian S
authors.initials: IS
authors.lastname: Armstrong
authors.forename: Thomas E
authors.initials: TE
authors.lastname: La Cruz
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D006571:Heterocyclic Compounds; D011743:Pyrimidines; D014230:Triazoles; C045575:1,2,4-triazole