title: Identification and analysis of microRNAs in the left ventricular myocardium of two-kidney one-clip hypertensive rats.
abstract: MicroRNAs (miRNAs) are involved in the regulation of numerous physiological and pathological processes. However, little information is available with regard to miRNAs in the left ventricular myocardium of the renovascular angiotensin-dependent hypertensive rat. In this study, miRNA expression profiles in the left ventricular myocardium of two-kidney one-clip (2K1C) hypertensive rats were analyzed using a microarray. The roles of the differentially expressed miRNAs, their target genes and signaling pathways were analyzed using ingenuity pathway analysis (IPA) for the first time to further elucidate the molecular mechanisms of left ventricular remodeling.
authors.affiliation: Research Institute of Hypertension, Department of Cardiovascular Medicine, The Second Affiliated Hospital, Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014030, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Sun
authors.forename: Hai
authors.initials: H
authors.lastname: Hu
authors.forename: Xuyang
authors.initials: X
authors.lastname: Tian
authors.forename: Jianwei
authors.initials: J
authors.lastname: Yue
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Yang
authors.forename: Zhanli
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D019295:Computational Biology; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006352:Heart Ventricles / Q000378:metabolism*; D006978:Hypertension, Renovascular / Q000150:complications / Q000235:genetics*; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D015398:Signal Transduction; D020257:Ventricular Remodeling / Q000235:genetics*
chemical_list: D035683:MicroRNAs