title: New 23-spirocholestane derivatives from Ypsilandra thibetica.
abstract: Three new unusual 23-spirocholestane derivatives, ypsilanogenin (1), ypsilanogenin 3-O-β-D-glucopyranoside (2), and 4'-acetylypsilanogenin 3-O-β-D-glucopyranoside (3), were isolated from the whole plants of Ypsilandra thibetica. The structures of compounds 1-3 were deduced by spectroscopic and chemical methods, and the structure of 1 was further confirmed by a single-crystal diffraction analysis. All isolates were evaluated for their inhibitory activities against HIV-1.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
authors.forename: Bai-Bo
authors.initials: BB
authors.lastname: Xie
authors.forename: Chang-Xiang
authors.initials: CX
authors.lastname: Chen
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Guo
authors.forename: Yu-Ye
authors.initials: YY
authors.lastname: Li
authors.forename: Ya-Juan
authors.initials: YJ
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Ni
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Ning-Bo
authors.initials: NB
authors.lastname: Gong
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Lü
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002776:Cholestanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D002776:Cholestanes; D006027:Glycosides; D012503:Saponins; D013141:Spiro Compounds; C000589182:ypsilanogenin