title: Old and new: appropriate dosing for neonatal antifungal drugs in the nursery.
abstract: Candida infections are a source of significant mortality and morbidity in the neonatal intensive care unit. Treatment strategies continue to change as additional antifungals become available and studies in neonates are performed. Amphotericin B deoxycholate has been favored for many years, but fluconazole has the most data supporting its use in neonatal Candida infections and is often employed for prophylaxis as well as treatment. Voriconazole and posaconazole have limited utility in the nursery and are rarely used. The echinocandins are increasingly administered for invasive Candida infections, although higher doses are required in neonates than in older children and adults.
authors.affiliation: Duke University Medical Center, Durham, NC 27715, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Ericson
authors.forename: Paolo
authors.initials: P
authors.lastname: Manzoni
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Benjamin
mesh_terms: D000666:Amphotericin B / Q000493:pharmacokinetics / Q000627:therapeutic use; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D003840:Deoxycholic Acid / Q000493:pharmacokinetics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D054714:Echinocandins / Q000493:pharmacokinetics / Q000627:therapeutic use; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy* / Q000382:microbiology; D007363:Intensive Care Units, Neonatal; D009359:Neonatology / Q000379:methods* / Q000639:trends; D011743:Pyrimidines / Q000493:pharmacokinetics / Q000627:therapeutic use; D014230:Triazoles / Q000493:pharmacokinetics / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D011743:Pyrimidines; D014230:Triazoles; D003840:Deoxycholic Acid; C101425:posaconazole; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D015725:Fluconazole; D065819:Voriconazole