title: MIF: metastasis/MDSC-inducing factor?
abstract: Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor. Our results suggest that MIF is a potential therapeutic target for the prevention of metastasis as it regulates the tumor microenvironment.
authors.affiliation: Department of Pathology; University of Virginia; Charlottesville, VA.
authors.forename: Kendra D
authors.initials: KD
authors.lastname: Simpson
authors.forename: Janet V
authors.initials: JV
authors.lastname: Cross
keywords: MDSC; MIF; metastasis; sulforaphane; tautomerase; tumor microenvironment