title: Microcirculatory mechanisms in postnatal hypotension affecting premature infants.
abstract: BACKGROUND
  Hypotension remains a common complication in preterm infants and is associated with high neonatal morbidity and mortality. The underlying mechanisms are still not fully understood. We studied the microcirculation in extremely low birth weight infants to understand the relationship between blood pressure and skin perfusion.
  
  
  METHODS
  In 21 patients (gestational age <30 wk, birth weight <1,225 g), functional vessel density (FVD) and diameter distribution were obtained prospectively by side stream dark-field imaging at the right arm in the first 48 h after birth. Infants with blood pressure below gestational age and receiving catecholamines were defined as hypotensive as compared with the remaining normotensive control group.
  
  
  RESULTS
  In the first 6 h after birth, FVD was significantly higher in the hypotensive group than in the control group. After 12 h, there were no significant differences in either blood pressure or FVD between the two groups. FVD did not change significantly during the observation period in either group.
  
  
  CONCLUSIONS
  Hypotensive infants have a higher FVD, possibly due to loss of microvascular tone leading to vasodilation and flow redistribution. However, the link between blood pressure and perfusion remains unclear, and no definitive correlation could be found.
authors.affiliation: Division of Neonatology, Dr. von Hauner Children's Hospital, University of Munich, Munich, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schwepcke
authors.forename: Florian D
authors.initials: FD
authors.lastname: Weber
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Mormanova
authors.forename: Bystrik
authors.initials: B
authors.lastname: Cepissak
authors.forename: Orsolya
authors.initials: O
authors.lastname: Genzel-Boroviczény
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D005858:Germany; D006801:Humans; D007022:Hypotension / Q000503:physiopathology*; D052577:Infant, Extremely Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008833:Microcirculation / Q000502:physiology*; D011446:Prospective Studies; D012867:Skin / Q000098:blood supply