title: Intracranial glioblastoma with drop metastases to the spine after stereotactic biopsy.
abstract: BACKGROUND
  Glioblastoma (GBM) is the most common primary intracranial tumor, but metastases are rarely reported. Previous reports have documented the occurrence of drop metastases to the spine. However, few of these reports have demonstrated the occurrence of spinal metastases after biopsy with stable intracranial disease. Here we present such a case.
  
  
  METHODS
  We present a case of GBM metastatic to the spinal cord after a stereotactic biopsy with stable intracranial disease. To our knowledge, this occurrence has only been reported in one previous case.
  
  
  CONCLUSIONS
  We propose that traversing the lateral ventricle at the time of biopsy contributed to cerebrospinal fluid seeding with tumor cells and subsequent development of spinal disease.
authors.affiliation: Department of Neurosurgery, University of Arkansas for Medical Sciences' College of Medicine, Little Rock, Arkansas, United States.
authors.forename: Gregory
authors.initials: G
authors.lastname: Albert
authors.affiliation: Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Shafik
authors.initials: S
authors.lastname: Wassef
authors.forename: Nader S
authors.initials: NS
authors.lastname: Dahdaleh
authors.affiliation: Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Nader
authors.initials: N
authors.lastname: Dahdaleh
authors.affiliation: Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Timothy
authors.initials: T
authors.lastname: Lindley
authors.affiliation: Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Leslie
authors.initials: L
authors.lastname: Bruch
authors.affiliation: Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Patrick
authors.initials: P
authors.lastname: Hitchon
mesh_terms: D001706:Biopsy / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000473:pathology*; D059248:Chemoradiotherapy; D003221:Confusion / Q000209:etiology; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009366:Neoplasm Seeding; D013125:Spinal Neoplasms / Q000556:secondary*; D013238:Stereotaxic Techniques