title: Electrocardiogram classification using delay differential equations.
abstract: Time series analysis with nonlinear delay differential equations (DDEs) reveals nonlinear as well as spectral properties of the underlying dynamical system. Here, global DDE models were used to analyze 5 min data segments of electrocardiographic (ECG) recordings in order to capture distinguishing features for different heart conditions such as normal heart beat, congestive heart failure, and atrial fibrillation. The number of terms and delays in the model as well as the order of nonlinearity of the model have to be selected that are the most discriminative. The DDE model form that best separates the three classes of data was chosen by exhaustive search up to third order polynomials. Such an approach can provide deep insight into the nature of the data since linear terms of a DDE correspond to the main time-scales in the signal and the nonlinear terms in the DDE are related to nonlinear couplings between the harmonic signal parts. The DDEs were able to detect atrial fibrillation with an accuracy of 72%, congestive heart failure with an accuracy of 88%, and normal heart beat with an accuracy of 97% from 5 min of ECG, a much shorter time interval than required to achieve comparable performance with other methods.
authors.affiliation: Computational Neurobiology Laboratory, Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
authors.forename: Claudia
authors.initials: C
authors.lastname: Lainscsek
authors.forename: Terrence J
authors.initials: TJ
authors.lastname: Sejnowski
mesh_terms: D001281:Atrial Fibrillation / Q000503:physiopathology; D004562:Electrocardiography / Q000145:classification*; D006333:Heart Failure / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D017711:Nonlinear Dynamics; D012372:ROC Curve