title: Highly efficient asymmetric additions of diethylzinc to aldehydes triply activated by chiral phosphoramide-Zn(II) complexes derived from cinchona alkaloids.
abstract: New chiral phosphoramide ligands derived from cinchona alkaloids were developed, which react with diethylzinc to form chiral phosphoramide-Zn(II) complexes containing two Lewis bases and one Lewis acid. These trifunctional complexes can serve as highly efficient chiral catalysts for triple activation of enantioselective addition reactions of diethylzinc with aldehydes to give desired alcohol products with excellent yields and enantiomeric excess (ee) values up to 99%.
authors.affiliation: The Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Chinese Academy of Sciences, Fuzhou, Fujian, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Shen
authors.forename: Huayin
authors.initials: H
authors.lastname: Huang
authors.forename: Guangling
authors.initials: G
authors.lastname: Bian
authors.forename: Hua
authors.initials: H
authors.lastname: Zong
authors.forename: Ling
authors.initials: L
authors.lastname: Song
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D063088:Phosphoramides / Q000737:chemistry*; D011803:Quinine / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D002930:Cinchona Alkaloids; D008024:Ligands; D009942:Organometallic Compounds; D063088:Phosphoramides; C005438:phosphoramide; D011803:Quinine; C454811:diethylzinc
keywords: cinchona alkaloids; diethylzinc; enantioselective addition; phosphoramide; triple activation