title: Triterpene saponins from Clematis mandshurica and their antiproliferative activity.
abstract: Six new triterpene saponins, clematomandshurica saponins F-K (1-6), together with a known compound (7), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis. Compounds 5-7 exhibited antiproliferative effects against PC-3 human prostate cancer cells with GI50 values of 1.29, 1.50, and 0.71 µM, respectively.
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China.
authors.forename: Yi-Xia
authors.initials: YX
authors.lastname: Gong
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
authors.forename: Yong-Nan
authors.initials: YN
authors.lastname: Xu
authors.forename: Jian-Yu
authors.initials: JY
authors.lastname: Liu
authors.forename: Zong-Gui
authors.initials: ZG
authors.lastname: Yu
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Yong-Kui
authors.initials: YK
authors.lastname: Jing
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002247:Carbon Isotopes / Q000032:analysis; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival; D002681:China; D039324:Clematis / Q000737:chemistry*; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002247:Carbon Isotopes; D012503:Saponins; D014315:Triterpenes