title: Concentrations of C-reactive protein, serum amyloid A, and haptoglobin in uterine arterial and peripheral blood in bitches with pyometra.
abstract: Pyometra is a life-threatening reproductive disorder that affects the uterus of female dogs. This study was designed to identify the possible indicators of uterine inflammation by comparing C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (Hp) concentrations in uterine arterial and peripheral venous blood in bitches with open- and closed-cervix pyometra. CRP, SAA, and Hp concentrations were higher in bitches with closed-cervix pyometra irrespective of the site of blood collection. Higher acute-phase protein concentrations were observed in peripheral compared with uterine arterial blood in bitches with closed-cervix pyometra, whereas the levels were comparable in dogs with open-cervix pyometra. Our results indicate that mean acute-phase protein concentrations differ according to pyometra type/severity and blood source and suggest the possible use of peripheral blood levels of CRP, SAA, and Hp to monitor inflammation during the course of pyometra.
authors.affiliation: Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland. roman.dabrowski@up.lublin.pl
authors.forename: Roman
authors.initials: R
authors.lastname: Dąbrowski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kostro
authors.forename: Marek
authors.initials: M
authors.lastname: Szczubiał
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006242:Haptoglobins / Q000378:metabolism*; D055112:Pyometra / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism / Q000662:veterinary*; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D014463:Ultrasonography; D055988:Uterine Artery / Q000378:metabolism*
chemical_list: D006242:Haptoglobins; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein
keywords: Acute-phase proteins; CRP; Hp; Local and systemic inflammatory response; Pyometra; SAA