title: Enhancement of the antifungal activity of antimicrobial drugs by Eugenia uniflora L.
abstract: Candidiasis is the most frequent infection by opportunistic fungi such as Candida albicans, Candida tropicalis, and Candida krusei. Ethanol extract from Eugenia uniflora was assayed, for its antifungal activity, either alone or combined with four selected chemotherapeutic antimicrobial agents, including anphotericin B, mebendazole, nistatin, and metronidazole against these strains. The obtained results indicated that the association of the extract of E. uniflora to metronidazole showed a potential antifungal activity against C. tropicalis. However, no synergistic activity against the other strains was observed, as observed when the extract was associated with the other, not enhancing their antifungal activity.
authors.affiliation: Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, Brazil.
authors.forename: Karla K A
authors.initials: KK
authors.lastname: Santos
authors.forename: Edinardo F F
authors.initials: EF
authors.lastname: Matias
authors.forename: Saulo R
authors.initials: SR
authors.lastname: Tintino
authors.forename: Celestina E S
authors.initials: CE
authors.lastname: Souza
authors.forename: Maria F B M
authors.initials: MF
authors.lastname: Braga
authors.forename: Gláucia M M
authors.initials: GM
authors.lastname: Guedes
authors.forename: José G M
authors.initials: JG
authors.lastname: Costa
authors.forename: Irwin R A
authors.initials: IR
authors.lastname: Menezes
authors.forename: Henrique Douglas Melo
authors.initials: HD
authors.lastname: Coutinho
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D004338:Drug Combinations; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D027842:Syzygium / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D010936:Plant Extracts