title: Two cases of hypersexuality probably associated with aripiprazole.
abstract: Sexual dysfunction is a common side effect in patients treated with antipsychotics but significant differences exist across different compounds. We report hypersexuality symptoms in two female patients with schizophrenia who were receiving treatment with aripiprazole. The patients experienced more frequent sexual desire and greater sexual preoccupation after taking aripiprazole. We discuss the potential neuro-chemical mechanisms for this and argue that aripiprazole's unique pharmacological profile, partial agonism with high affinity at dopamine D2-receptor, may have contributed to the development of these symptoms.
authors.affiliation: Department of Psychiatry, Yeungnam University College of Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.
authors.forename: Eunjin
authors.initials: E
authors.lastname: Cheon
authors.forename: Bon-Hoon
authors.initials: BH
authors.lastname: Koo
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Seo
authors.forename: Jun-Yeob
authors.initials: JY
authors.lastname: Lee
keywords: Aripiprazole; Dopamine; Hypersexuality; Partial agonist