title: [Resolving factors of inflammation - a bridge between innate immunity and adaptive immunity].
abstract: Acute inflammation, a physiologic response to protect cells from microbial infection and other stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and can progress to a chronic inflammation such as rheumatoid arthritis, interstitial pneumonitis. To prevent chronic inflammation, understanding the process that resolves inflammation is essential. Resolution of inflammation is an active coordinated process regulated by distinct anti-inflammatory and pro-resolving endogenous lipid mediators, such as lipoxins/ALX, chemerin/chemR23. In resolution of inflammation these resolving factors contribute a bridge between innate and adaptive immunity.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Toho University.
authors.forename: Hirahito
authors.initials: H
authors.lastname: Endo
mesh_terms: D016718:Arachidonic Acid / Q000502:physiology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D018925:Chemokines / Q000502:physiology; D006801:Humans; D007110:Immunity, Active / Q000502:physiology*; D007113:Immunity, Innate / Q000502:physiology*; D058847:Inflammasomes / Q000276:immunology*; D036341:Intercellular Signaling Peptides and Proteins; D044045:Lipoxins / Q000502:physiology; D017563:Lung Diseases, Interstitial / Q000276:immunology
chemical_list: D018925:Chemokines; D058847:Inflammasomes; D036341:Intercellular Signaling Peptides and Proteins; D044045:Lipoxins; C478630:RARRES2 protein, human; C040527:lipoxin A4; D016718:Arachidonic Acid