title: Facile synthesis of camptothecin intercalated layered double hydroxide nanohybrids via a coassembly route.
abstract: A method has been developed for the synthesis of intercalated layered double hydroxide (LDH) nanohybrids of the charge-neutral and poorly water-soluble anticancer drug camptothecin (CPT) using a coassembly route. For this route, CPT molecules were initially incorporated into the micelles of a biocompatible surfactant, such as sodium cholate (SCh) or sodium deoxycholate (SDC). The resulting negatively charged CPT-loaded micelles and the positively charged LDH nanosheets were then coassembled together into the CPT intercalated LDH nanohybrids. The resulting nanohybrids were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) and elemental analyses. The results revealed that the loading of CPT in the nanohybrids could reach as high as 13%, indicating that this route could be used to achieve the effective intercalation of charge-neutral and poorly water-soluble drugs into the LDH gallery. The in vitro release of CPT from the nanohybrids was examined, and the results showed that the release was a diffusion-controlled process and that the diffusion process through the LDH particles was the rate-limiting step. The parabolic diffusion equation effectively described the kinetic process associated with the release of CPT from the nanohybrids.
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry (Ministry of Education), Shandong University, Jinan 250100, PR China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Wu
authors.forename: Haiping
authors.initials: H
authors.lastname: Li
authors.forename: Shue
authors.initials: S
authors.lastname: Song
authors.forename: Renjie
authors.initials: R
authors.lastname: Zhang
authors.forename: Wanguo
authors.initials: W
authors.lastname: Hou
mesh_terms: D002166:Camptothecin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D003840:Deoxycholic Acid / Q000737:chemistry; D004058:Diffusion; D006878:Hydroxides / Q000138:chemical synthesis*; D007700:Kinetics; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D053758:Nanoparticles; D036103:Nanotechnology; D020358:Sodium Cholate / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D059004:Topoisomerase I Inhibitors / Q000138:chemical synthesis*
chemical_list: D006878:Hydroxides; D008823:Micelles; D013501:Surface-Active Agents; D059004:Topoisomerase I Inhibitors; D003840:Deoxycholic Acid; D020358:Sodium Cholate; D002166:Camptothecin
keywords: Camptothecin; Coassembly; Layered double hydroxide; Nanohybrid; Release