title: Histone deacetylases in herpesvirus replication and virus-stimulated host defense.
abstract: Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.
authors.affiliation: Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Guise
authors.forename: Hanna G
authors.initials: HG
authors.lastname: Budayeva
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Diner
authors.forename: Ileana M
authors.initials: IM
authors.lastname: Cristea
mesh_terms: D000107:Acetylation; D006564:Herpesviridae / Q000276:immunology* / Q000502:physiology*; D006655:Histone Deacetylases / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D055442:Metabolome; D011499:Protein Processing, Post-Translational; D040901:Proteomics; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D014764:Viral Proteins; D006655:Histone Deacetylases