title: Bacterial peritonitis due to Acinetobacter baumannii sequence type 25 with plasmid-borne new delhi metallo-β-lactamase in Honduras.
abstract: A carbapenem-resistant Acinetobacter baumannii strain was isolated from the peritoneal fluid of a patient with complicated intra-abdominal infection and evaluated at the Multidrug-resistant Organism Repository and Surveillance Network by whole-genome sequencing and real-time PCR. The isolate was sequence type 25 and susceptible to colistin and minocycline, with low MICs of tigecycline. blaNDM-1 was located on a plasmid with >99% homology to pNDM-BJ02. The isolate carried numerous other antibiotic resistance genes, including the 16S methylase gene, armA.
authors.affiliation: Multidrug-resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA. paige.e.waterman.mil@mail.mil
authors.forename: Paige E
authors.initials: PE
authors.lastname: Waterman
authors.forename: Patrick
authors.initials: P
authors.lastname: McGann
authors.forename: Erik
authors.initials: E
authors.lastname: Snesrud
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Clifford
authors.forename: Yoon I
authors.initials: YI
authors.lastname: Kwak
authors.forename: Ivón P
authors.initials: IP
authors.lastname: Munoz-Urbizo
authors.forename: Juana
authors.initials: J
authors.lastname: Tabora-Castellanos
authors.forename: Michael
authors.initials: M
authors.lastname: Milillo
authors.forename: Lan
authors.initials: L
authors.lastname: Preston
authors.forename: Ricardo
authors.initials: R
authors.lastname: Aviles
authors.forename: Deena E
authors.initials: DE
authors.lastname: Sutter
authors.forename: Emil P
authors.initials: EP
authors.lastname: Lesho
mesh_terms: D000151:Acinetobacter Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003091:Colistin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D059014:High-Throughput Nucleotide Sequencing; D006721:Honduras; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D010538:Peritonitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D010957:Plasmids; D000078304:Tigecycline; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; C446079:16S rRNA - m7G methyltransferase; D008780:Methyltransferases; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; D008911:Minocycline; D003091:Colistin