title: Sweet nothings: sensing of sugar metabolites controls T cell function.
abstract: Signal transduction and metabolism cooperate to control cell fate, but mechanisms that link metabolic substrates to functional decisions are elusive. Now, Chang et al. (2013) in Cell provide a mechanism whereby available sugars dictate metabolic pathways in activated T cells and direct a nonmetabolic regulatory function of glyceraldehyde-3-phosphate dehydrogenase.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. douglas.green@stjude.org
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Green
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rathmell
mesh_terms: D000818:Animals; D006019:Glycolysis; D008213:Lymphocyte Activation; D010085:Oxidative Phosphorylation; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism*