title: Peptide hydrogels assembled from nonionic alkyl-polypeptide amphiphiles prepared by ring-opening polymerization.
abstract: Three alkyl-polypeptide (AP) amphiphiles were prepared using ring-opening polymerization of α-amino acid N-carboxyanhydride. The polypeptide segment was composed of diethylene-glycol-monomethyl-ether-functionalized poly-L-glutamate (poly-L-EG(2)Glu). These AP amphiphiles can spontaneously self-assemble into transparent hydrogels in water. These hydrogels showed shear thinning properties, and their strength can be modulated by hydrophobic alkyl tails. CryoTEM and AFM characterizations suggested that these hydrogels were formed by nanoribbons arising from intermolecular interactions between nonionic poly-L-EG(2)Glu segments.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, China.
authors.forename: Chongyi
authors.initials: C
authors.lastname: Chen
authors.forename: Decheng
authors.initials: D
authors.lastname: Wu
authors.forename: Wenxin
authors.initials: W
authors.lastname: Fu
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Li
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis; D020285:Cryoelectron Microscopy; D005971:Glutamates / Q000138:chemical synthesis; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis*; D057927:Hydrophobic and Hydrophilic Interactions; D046529:Microscopy, Electron, Transmission; D037742:Nanotubes, Carbon / Q000737:chemistry / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry*; D058105:Polymerization; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D005971:Glutamates; D020100:Hydrogels; D037742:Nanotubes, Carbon; D010455:Peptides; D013501:Surface-Active Agents