title: Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report.
abstract: The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.
authors.affiliation: Divisione di Cardiologia Riabilitativa, Fondazione Salvatore Maugeri, IRCCS, Veruno, NO, Italy. ermanno.eleuteri@fsm.it
authors.forename: Ermanno
authors.initials: E
authors.lastname: Eleuteri
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mezzani
authors.forename: Antonino
authors.initials: A
authors.lastname: Di Stefano
authors.forename: Davide
authors.initials: D
authors.lastname: Vallese
authors.forename: Isabella
authors.initials: I
authors.lastname: Gnemmi
authors.forename: Lorena
authors.initials: L
authors.lastname: Delle Donne
authors.forename: Adriano
authors.initials: A
authors.lastname: Taddeo
authors.forename: Silvia
authors.initials: S
authors.lastname: Della Bella
authors.forename: Pantaleo
authors.initials: P
authors.lastname: Giannuzzi
mesh_terms: D000368:Aged; D042501:Angiogenic Proteins / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001916:Brachial Artery / Q000503:physiopathology; D002908:Chronic Disease; D042783:Endothelial Cells / Q000378:metabolism; D015444:Exercise; D005081:Exercise Therapy; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D010865:Pilot Projects; D011446:Prospective Studies; D013234:Stem Cells / Q000378:metabolism; D013318:Stroke Volume; D016896:Treatment Outcome; D014664:Vasodilation
chemical_list: D042501:Angiogenic Proteins; D015415:Biomarkers