title: Topology of blood transport in the human left ventricle by novel processing of Doppler echocardiography.
abstract: Novel processing of Doppler-echocardiography data was used to study blood transport in the left ventricle (LV) of six patients with dilated cardiomyopathy and six healthy volunteers. Bi-directional velocity field maps in the apical long axis of the LV were reconstructed from color-Doppler echocardiography. Resulting velocity field data were used to perform trajectory-based computation of Lagrangian coherent structures (LCS). LCS were shown to reveal the boundaries of blood injected and ejected from the heart over multiple beats. This enabled qualitative and quantitative assessments of blood transport patterns and residence times in the LV. Quantitative assessments of stasis in the LV are reported, as well as characterization of LV vortex formations from E-wave and A-wave filling.
authors.affiliation: Department of Mechanical, Materials and Aerospace Engineering, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Sahar
authors.initials: S
authors.lastname: Hendabadi
authors.forename: Javier
authors.initials: J
authors.lastname: Bermejo
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Benito
authors.forename: Raquel
authors.initials: R
authors.lastname: Yotti
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández-Avilés
authors.forename: Juan C
authors.initials: JC
authors.lastname: del Álamo
authors.forename: Shawn C
authors.initials: SC
authors.lastname: Shadden
mesh_terms: D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018618:Echocardiography, Doppler, Color; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D016276:Ventricular Function