title: The methylenetetrahydrofolate reductase C677T polymorphism influences risk of esophageal cancer in Chinese.
abstract: Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism. This study with 381 esophageal cancer patients and 432 healthy controls was conducted to examine the association of MTHFR C677T and A1298C polymorphisms with susceptibility to esophageal cancer (EC) in a Chinese population. Compared with the CC genotype of MTHFR C677T, subjects carrying homozygote TT and variant genotypes (CT+TT) demonstrated reduced risk of EC with adjusted ORs (95% CI) of 0.44 (0.28-0.71) and 0.57 (0.37-0.88), respectively. However, no association was found between the MTHFR A1298C polymorphism and the risk of EC. Comparing to haplotype CA, haplotypes TA and TC could reduce the susceptibility to EC with adjusted ORs (95% CI) of 0.61(0.47-0.79) and 0.06 (0.01-0.43), respectively. In conclusion, the present study suggested that the MTHFR C677T polymorphism can markedly influence the risk of EC in Chinese.
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China E-mail : lpdai@zzu.edu.cn.
authors.forename: Hong-Hong
authors.initials: HH
authors.lastname: Qu
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Cui
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Song
authors.forename: Kai-Juan
authors.initials: KJ
authors.lastname: Wang
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Zhang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Dai
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)