title: There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study.
abstract: BACKGROUND
  Endometriosis is a chronic condition whose pathophysiology is unknown, but there is evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease (minimal/mild and moderate/severe).
  
  
  METHODS
  80 infertile women with endometriosis diagnosed by laparoscopy/laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal/mild (n = 33) and moderate/severe (n = 47) cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined.
  
  
  RESULTS
  The paraoxonase activity were 191.29 ± 22.41 U/l in women with minimal/mild endometriosis and 224.85 ± 21.50 U/l in women with moderate/severe disease (P = 0.274). Considering arilesterase level, the results showed 89.82 ± 4.61 U/l in women with minimal/mild endometriosis and 90.78 ± 3.43 U/l in moderate/severe disease (P = 0.888).
  
  
  CONCLUSIONS
  Evidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal/mild or moderate/severe endometriosis.
authors.affiliation: Division of Biochemistry, Department of Morphology, Faculdade de Medicina do ABC, Santo André, Santo André/SP, Brazil.
authors.forename: Felipe Barca
authors.initials: FB
authors.lastname: Bragatto
authors.forename: Caio Parente
authors.initials: CP
authors.lastname: Barbosa
authors.forename: Denise Maria
authors.initials: DM
authors.lastname: Christofolini
authors.forename: Carla
authors.initials: C
authors.lastname: Peluso
authors.forename: Aline Amaro
authors.initials: AA
authors.lastname: dos Santos
authors.forename: Fernanda Abani
authors.initials: FA
authors.lastname: Mafra
authors.forename: Viviane
authors.initials: V
authors.lastname: Cavalcanti
authors.forename: Sonia
authors.initials: S
authors.lastname: Hix
authors.forename: Bianca
authors.initials: B
authors.lastname: Bianco
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D004715:Endometriosis / Q000097:blood* / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications; D018384:Oxidative Stress
chemical_list: D043303:Aryldialkylphosphatase