title: Dengue hepatitis sans dysfunction: experience of a single tertiary referral centre in the north Indian state of Uttarakhand.
abstract: Hepatic involvement is uncommon in dengue viral infections and is traditionally thought to be associated with severe disease in terms of morbidity and mortality. This study was conducted in order to assess the liver function in patients with dengue virus infection and to analyse its effect upon patient outcome. Three hundred and twenty-seven consecutive patients with dengue virus were categorized into groups A, B, C and D on the basis of elevation of either of the hepatic transaminases (normal, <3, 3-10 and >10 times, respectively). Primary and secondary outcome measures related to morbidity and mortality were studied. Hepatitis was seen in ∼3/4 patients; an increasing grade of liver involvement was significantly associated with fewer platelets (P < 0.001). Recovery of platelets, bleeding manifestations, renal dysfunction, platelet recovery and duration of hospitalization were similar in all groups. Among the patients with manifest bleeding, the platelet count did not differ significantly but the platelet recovery was significantly slower (P = 0.044) with increasing grade. Hepatic dysfunction is self-limited without any increase in morbidity and mortality.
authors.affiliation: Department of Medicine, Himalayan Institute of Medical Sciences, HIHT University, Swami Ram Nagar, Jolly Grant, PO Doiwala, Dehradun, Uttarakhand 248140, India. sohadia@hotmail.com
authors.forename: Sohaib
authors.initials: S
authors.lastname: Ahmad
authors.forename: Minakshi
authors.initials: M
authors.lastname: Dhar
authors.forename: Saurabh
authors.initials: S
authors.lastname: Srivastava
authors.forename: Nowneet K
authors.initials: NK
authors.lastname: Bhat
authors.forename: Nadia
authors.initials: N
authors.lastname: Shirazi
authors.forename: Debasis
authors.initials: D
authors.lastname: Biswas
authors.forename: Monil
authors.initials: M
authors.lastname: Kadian
authors.forename: Santosh
authors.initials: S
authors.lastname: Ghai
mesh_terms: D000328:Adult; D000368:Aged; D003715:Dengue / Q000150:complications*; D005260:Female; D006505:Hepatitis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007194:India; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
keywords: Dengue fever; bleeding; liver dysfunction; platelet recovery time; thrombocytopenia