title: Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology.
abstract: With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.
authors.affiliation: Department of Laboratory Medicine, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno 656 53, Czech Republic.
authors.forename: Katerina
authors.initials: K
authors.lastname: Pilatova
authors.forename: Kristina
authors.initials: K
authors.lastname: Greplova
authors.forename: Regina
authors.initials: R
authors.lastname: Demlova
authors.forename: Beatrix
authors.initials: B
authors.lastname: Bencsikova
authors.forename: Giannoula Lakka
authors.initials: GL
authors.lastname: Klement
authors.forename: Lenka
authors.initials: L
authors.lastname: Zdrazilova-Dubska
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000097:blood* / Q000276:immunology / Q000473:pathology; D009389:Neovascularization, Pathologic; D010455:Peptides / Q000097:blood*; D010978:Platelet Factor 4 / Q000097:blood*
chemical_list: D010455:Peptides; D010978:Platelet Factor 4; C009862:connective tissue-activating peptide