title: Reduced orexin-A levels in frontotemporal dementia: possible association with sleep disturbance.
abstract: Sleep disturbances including excessive daytime sleepiness (EDS) are encountered in frontotemporal dementia (FTD). To investigate the relationship between the plasma orexin-A levels and sleep disturbance patterns, we measured the plasma orexin-A levels and performed sleep studies in patients with FTD. The orexin-A levels were measured in 10 consecutive patients with FTD and controls by enzyme-linked immunosorbent assay. Nocturnal polysomnography (PSG) and Multiple Sleep Latency Test (MSLT) were performed in 2 patients with FTD. The orexin-A levels were significantly lower in patients with FTD compared to controls. The PSG revealed increased rapid eye movement (REM) latency in patients, whether or not they reported EDS. Mean sleep latency in MSLT was less than 10 minutes in both the patients, being shorter in patient without EDS, but none of them had REM sleep onset. Some patients with FTD may develop narcolepsy-like involuntary sleep attacks, even without complaining of EDS. Involvement of hypothalamus and a subsequent alteration in the orexin levels might be one of the determining factors in this sleep disturbance.
authors.affiliation: Department of Neurology, Istanbul Faculty of Medicine, Istanbul, Turkey. arzucoban2002@yahoo.com
authors.forename: Arzu
authors.initials: A
authors.lastname: Çoban
authors.forename: Basar
authors.initials: B
authors.lastname: Bilgiç
authors.forename: Ebba
authors.initials: E
authors.lastname: Lohmann
authors.forename: Cem İsmail
authors.initials: Cİ
authors.lastname: Küçükali
authors.forename: Gülçin
authors.initials: G
authors.lastname: Benbir
authors.forename: Derya
authors.initials: D
authors.lastname: Karadeniz
authors.forename: Hasmet A
authors.initials: HA
authors.lastname: Hanagasi
authors.forename: Erdem
authors.initials: E
authors.lastname: Tüzün
authors.forename: Hakan
authors.initials: H
authors.lastname: Gürvit
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D005260:Female; D057180:Frontotemporal Dementia / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000097:blood*; D000068797:Orexins; D017286:Polysomnography; D012893:Sleep Wake Disorders / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology
chemical_list: C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins
keywords: frontotemporal dementia; orexin-A; plasma; polysomnography; sleep disturbances