title: Microemboli detection and classification during pediatric cardiopulmonary bypass.
abstract: Microemboli may be a cause of postoperative neurological morbidity. Improved detection of microemboli may lead to better strategies to minimize embolization and improve neurological outcomes. Transcranial Doppler may have limited sensitivity for very small microemboli. The Emboli Detection and Classification (EDAC) Quantifier offers increased sensitivity (10 μm) and potentially improved capability for microemboli monitoring. EDAC was used to measure microemboli in the cardiopulmonary bypass circuit during 33 pediatric heart operations. More microemboli were detected in the venous than the arterial line (median, 11,830 vs 1298). Venous microemboli tended to be larger in size than arterial microemboli (>40 μm; 59% vs 7%). Increased venous and arterial microemboli were seen at the onset of bypass; increased venous microemboli were also seen with clamp removal. Thousands of microemboli <40 μm are transmitted to pediatric patients during heart surgery. Initiation of bypass may be a key offender and may result from air in the venous line. Although the significance of microemboli remains unknown, increased awareness may lead to improved techniques to minimize microemboli, with improvement in neurological outcomes.
authors.affiliation: Department of Pediatrics, Penn State Hershey, Hershey, Pennsylvania.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Clark
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.forename: Yulong
authors.initials: Y
authors.lastname: Guan
authors.forename: Karl R
authors.initials: KR
authors.lastname: Woitas
authors.forename: John L
authors.initials: JL
authors.lastname: Myers
authors.forename: Akif
authors.initials: A
authors.lastname: Undar
keywords: cardiopulmonary bypass; cerebral complications; congenital heart surgery; embolism; ultrasound