title: Levosimendan in a neonate with severe coarctation of aorta and low cardiac output syndrome.
abstract: We report successful use of levosimendan after failed balloon angioplasty in a critically ill neonate with coarctation of aorta (CoA) and severe low cardiac output syndrome (LCOS). Treatment with levosimendan improved left heart function, and decreased lactate and brain natriuretic peptide levels. To our knowledge, this is the first report on the safe and successful use of levosimendan in the management of LCOS due to severe CoA in a neonate awaiting surgical repair.
authors.affiliation: Department of Pediatric Cardiac Anesthesiology and Intensive Care, Necker-Sick Children Hospital, Paris, France.
authors.forename: Yann Olivier
authors.initials: YO
authors.lastname: Boegli
authors.forename: Simone
authors.initials: S
authors.lastname: Gioanni
authors.forename: Mathieu
authors.initials: M
authors.lastname: van Steenberghe
authors.forename: Philippe
authors.initials: P
authors.lastname: Pouard
mesh_terms: D000800:Angioplasty, Balloon; D001017:Aortic Coarctation / Q000150:complications* / Q000601:surgery / Q000628:therapy; D002303:Cardiac Output, Low / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D006801:Humans; D006835:Hydrazones; D007231:Infant, Newborn; D019344:Lactic Acid / Q000097:blood; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011724:Pyridazines; D000077464:Simendan; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D002316:Cardiotonic Agents; D006835:Hydrazones; D011724:Pyridazines; D014665:Vasodilator Agents; D020097:Natriuretic Peptide, Brain; D019344:Lactic Acid; D000077464:Simendan