title: Zantholic acid, a new monoterpenoid from Zanthoxylum zanthoxyloides.
abstract: From the extract of Zanthoxylum zanthoxyloides fruits, a new menthane monoterpenoid, (4R,7R)-8-carboxy-7,9-dihydroxy-trans-menthane, tentatively, named as zantholic acid along with several known compounds was isolated. Its structure was determined using spectroscopic methods. The cytotoxic activity of zantholic acid against a panel of cancer cell lines was evaluated using the MTT assay. The results show that zantholic acid possesses a selective cytotoxic activity towards breast cancer cell lines.
authors.affiliation: a CSIR-Central Institute of Medicinal and Aromatic Plants , Lucknow , 226015 , India.
authors.forename: N A
authors.initials: NA
authors.lastname: Vyry Wouatsa
authors.forename: L N
authors.initials: LN
authors.lastname: Misra
authors.forename: R
authors.initials: R
authors.lastname: Venkatesh Kumar
authors.forename: Mahendra P
authors.initials: MP
authors.lastname: Darokar
authors.forename: Francois
authors.initials: F
authors.lastname: Tchoumbougnang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts