title: Association study between gene polymorphisms in PPAR signaling  pathway and porcine meat quality traits.
abstract: There is increasing evidence suggesting that fatty acids biosynthesis and metabolism are regulated by peroxisome proliferator-activated receptors (PPARs), mostly through the PPAR signaling pathway at the transcriptomic level. We hypothesized that the genetic variants of the enzymes in the PPAR signaling pathway may be associated with the traits of porcine meat quality (PMQ). We mined 77 potentially functional single nucleotide polymorphisms in the PPAR signaling pathway of the pig. There were 13 TagSNPs in 13 different genes mapped within the reported pig quantitative trait loci (QTLs) regions related to PMQ based on the Pig QTL database. Based on the association study with ten measured PMQ traits in both the pathway level and the SNP level, we tested eight significantly associated traits with additive effect in the PPAR signaling pathway and explored only one significant TagSNP in gene RXRB, which is directly associated with the trait of skin weight. Moreover, several interactions of TagSNPs were also significantly related to some of PMQ traits. In this large and comprehensive candidate gene set study, we found a modest association of genes and SNPs in the PPAR signaling pathway with PMQ. Further investigation of these gene polymorphisms jointly with fatty acid measures and other genetic factors would help us better understand the regulation mechanisms of PMQ.
authors.affiliation: Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China. hekan@sjtu.edu.cn
authors.forename: Kan
authors.initials: K
authors.lastname: He
authors.forename: Qishan
authors.initials: Q
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Pan
mesh_terms: D000818:Animals; D001483:Base Sequence; D005227:Fatty Acids / Q000096:biosynthesis; D063427:Food Quality; D005838:Genotype; D008460:Meat; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D040641:Quantitative Trait Loci / Q000235:genetics; D049230:Retinoid X Receptor beta / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000662:veterinary*; D015398:Signal Transduction / Q000235:genetics; D034421:Sus scrofa / Q000235:genetics
chemical_list: D005227:Fatty Acids; D047492:Peroxisome Proliferator-Activated Receptors; D049230:Retinoid X Receptor beta