title: [Molecular and pharmacogenetic mechanisms of severe asthma].
abstract: This review summarizes the results of studies to identify the dominant mechanisms of development and persistence of inflammation in severe asthma and results of pharmacogenetic studies of determination response to drugs. These mechanisms could potentially be used for diagnostic purposes and become the new targets of asthma therapy. Pharmacogenetic information will enable the use of a personalized approach to the asthma management which will adjust the therapy technology and increase the possibility of achieving disease control.
authors.forename: E S
authors.initials: ES
authors.lastname: Kulikov
authors.forename: L M
authors.initials: LM
authors.lastname: Ogorodova
authors.forename: M B
authors.initials: MB
authors.lastname: Freĭdin
authors.forename: I A
authors.initials: IA
authors.lastname: Deev
authors.forename: P A
authors.initials: PA
authors.lastname: Selivanova
authors.forename: S V
authors.initials: SV
authors.lastname: Fedosenko
authors.forename: N A
authors.initials: NA
authors.lastname: Kirillova
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use; D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D009389:Neovascularization, Pathologic; D010597:Pharmacogenetics / Q000379:methods; D011110:Polymorphism, Genetic; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D058666:Adrenergic beta-2 Receptor Agonists; D018927:Anti-Asthmatic Agents