title: [Prevention of cardiovascular complications in patients undergoing aortic-iliac reconstructions by correction of inflammation and endotoxemia].
abstract: There were presented the results of examination and treatment of 130 patients with atherosclerosis. Objective is to study the role of atorvastatin in correction of inflammation, endotoxemia and prevention of cardiovascular complications in patients with atherosclerosis undergoing aorto-iliac reconstruction. There were observed initial and postoperative activation of inflammation, endotoxemia in patients with multifocal atherosclerosis. We found that short-term therapy with atorvastatin 60 mg per day had a significant advantage over low-dose in correction of pre- and postoperative endogenous inflammation, endotoxemia and prevention of cardiac events after aorto-iliac reconstruction.
authors.forename: E A
authors.initials: EA
authors.lastname: Medvedeva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Shchukin
authors.forename: E I
authors.initials: EI
authors.lastname: Seleznev
mesh_terms: D001012:Aorta, Abdominal / Q000601:surgery; D050197:Atherosclerosis / Q000188:drug therapy / Q000601:surgery*; D000069059:Atorvastatin; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D019446:Endotoxemia / Q000188:drug therapy*; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007083:Iliac Artery / Q000601:surgery; D007249:Inflammation / Q000188:drug therapy*; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011758:Pyrroles / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin