title: The challenge of mild traumatic brain injury: role of biochemical markers in diagnosis of brain damage.
abstract: During the past decade there has been an increasing recognition of the incidence of mild traumatic brain injury (mTBI) and a better understanding of the subtle neurological and cognitive deficits that may result from it. A substantial, albeit suboptimal, effort has been made to define diagnostic criteria for mTBI and improve diagnostic accuracy. Thus, biomarkers that can accurately and objectively detect brain injury after mTBI and, ideally, aid in clinical management are needed. In this review, we discuss the current research on serum biomarkers for mTBI including their rationale and diagnostic performances. Sensitive and specific biomarkers reflecting brain injury can provide important information regarding TBI pathophysiology and serve as candidate markers for predicting abnormal computed tomography findings and/or the development of residual deficits in patients who sustain an mTBI. We also outline the roles of biomarkers in settings of specific interest including pediatric TBI, sports concussions and military injuries, and provide perspectives on the validation of such markers for use in the clinic. Finally, emerging proteomics-based strategies for identifying novel markers will be discussed.
authors.affiliation: Department of Neurosciences, University of Messina, 98125, Messina, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Mondello
authors.forename: Kara
authors.initials: K
authors.lastname: Schmid
authors.forename: Rachel P
authors.initials: RP
authors.lastname: Berger
authors.forename: Firas
authors.initials: F
authors.lastname: Kobeissy
authors.forename: Domenico
authors.initials: D
authors.lastname: Italiano
authors.forename: Andreas
authors.initials: A
authors.lastname: Jeromin
authors.forename: Ronal L
authors.initials: RL
authors.lastname: Hayes
authors.forename: Frank C
authors.initials: FC
authors.lastname: Tortella
authors.forename: Andras
authors.initials: A
authors.lastname: Buki
mesh_terms: D001265:Athletic Injuries / Q000097:blood / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D001924:Brain Concussion / Q000097:blood / Q000175:diagnosis; D001930:Brain Injuries / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism*; D003657:Decision Making; D006801:Humans
chemical_list: D015415:Biomarkers
keywords: biomarkers; concussion; diagnostic; mild TBI; traumatic brain injury