title: The role of the nonspecific inflammatory markers in determining the anatomic extent of venous thromboembolism.
abstract: We aimed to investigate the relationship between the extent of venous thromboembolism (VTE) and nonspecific inflammatory markers such as neutrophil to lymphocyte ratio (NLR) and high-sensitivity C-reactive protein (hs-CRP). We retrospectively enrolled 77 patients with VTE (distal deep vein thrombosis [DVT], n = 19; proximal DVT, n = 32; and pulmonary thromboembolism [PTE], n = 26) and 34 healthy controls. In the performed analysis of variance, the levels of white blood cell, NLR, and hs-CRP were clearly different among the groups (control, distal and proximal DVT, and PTE) (P < .001). Especially, a significant increase from the control group to the DVT and PTE was observed in the analysis made for NLR. In the performed receiver-operating characteristic curve analysis, area under curve (AUC) = 0.849 and P < .001 were detected for NLR > 1.84. For this value, the sensitivity and specificity were determined as 88.2% and 67.6%, respectively. The NLR is an inexpensive and a readily available marker that may be effective in determining the extent of VTE, and it is useful for risk stratification in patients with VTE.
authors.affiliation: Department of Cardiology, Bayburt State Hospital, Bayburt, Turkey eftalka@yahoo.com.
authors.forename: Eftal Murat
authors.initials: EM
authors.lastname: Bakirci
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Topcu
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Kamuran
authors.initials: K
authors.lastname: Kalkan
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Tanboga
authors.affiliation: Department of Cardiology, Sifa Hospital, Erzurum, Turkey.
authors.forename: Abdurrezzak
authors.initials: A
authors.lastname: Borekci
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Sevimli
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Acikel
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011655:Pulmonary Embolism / Q000097:blood* / Q000473:pathology; D012189:Retrospective Studies; D054556:Venous Thromboembolism / Q000097:blood* / Q000473:pathology; D020246:Venous Thrombosis / Q000097:blood* / Q000473:pathology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: deep venous thrombosis; pulmonary embolism; thrombosis