title: miR-146b-5p inhibits glioma migration and invasion by targeting MMP16.
abstract: miR-146b-5p is frequently down-regulated in solid tumours, including prostate cancer, pancreatic cancer, and glioblastoma. However, the tumour-suppressive effects of miR-146b-5p in malignant gliomas have not been investigated thoroughly. Here, we found that decreased miR-146b-5p expression was strongly correlated with chromosome 10q loss in gliomas, especially glioblastomas. The overexpression of miR-146b-5p in glioblastoma cell lines led to MMP16 mRNA silencing, MMP2 inactivation, and the inhibition of tumour cell migration and invasion. Our results suggest that the restoration of miR-146b-5p expression may be a feasible approach for inhibiting the migration and invasion of malignant gliomas.
authors.affiliation: Dept. of Neuropathology, Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin 300052, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Yu
authors.forename: Cuiyun
authors.initials: C
authors.lastname: Sun
authors.forename: Degang
authors.initials: D
authors.lastname: Cheng
authors.forename: Shizhu
authors.initials: S
authors.lastname: Yu
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Yaping
authors.initials: Y
authors.lastname: Yan
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Kang
authors.forename: Shumei
authors.initials: S
authors.lastname: Jin
authors.forename: Tongling
authors.initials: T
authors.lastname: An
authors.forename: Cuijuan
authors.initials: C
authors.lastname: Shi
authors.forename: Jinling
authors.initials: J
authors.lastname: Xu
authors.forename: Changjuan
authors.initials: C
authors.lastname: Wei
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Wen
authors.forename: Shujun
authors.initials: S
authors.lastname: Zhao
authors.forename: Yanling
authors.initials: Y
authors.lastname: Kong
mesh_terms: D001483:Base Sequence; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D018093:Gelatinases / Q000378:metabolism; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D005910:Glioma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D053513:Matrix Metalloproteinase 16 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D009361:Neoplasm Invasiveness
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs; D018093:Gelatinases; D053513:Matrix Metalloproteinase 16
keywords: Gliomas; Invasion; MMP16; Migration; miR-146b-5p