title: Spinal giant cell tumor in tuberous sclerosis: case report and review of the literature.
abstract: BACKGROUND
  Patients affected by tuberous sclerosis (TS) have a greater incidence of tumors than the healthy population. Spinal tumours in TS are reported very rarely and consist mainly of sacrococcygeal and cervical chordomas.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 21-year-old man, affected by TS, presented a spinal dorsal T2 tumor that caused medullary compression. He underwent decompressive laminectomy and microsurgical excision of a giant cell tumor and an associated aneurysmal bone cyst. Postoperative hypofractionated radiotherapy was performed on the surgical field. At 2.4 years of follow-up the patient reported total recovery of neurological deficits and was free from tumor recurrence.
  
  
  CONCLUSIONS
  Considering this association, which is the first reported in the literature, spinal magnetic resonance imaging with gadolinium should be performed at the onset of spinal pain in patients affected by TS.
authors.affiliation: University of Rome Tor Vergata, Rome, Italy. mff77@libero.it
authors.forename: Mario Francesco
authors.initials: MF
authors.lastname: Fraioli
authors.forename: Mario
authors.initials: M
authors.lastname: Lecce
authors.forename: Chiara
authors.initials: C
authors.lastname: Fraioli
authors.forename: Curatolo
authors.initials: C
authors.lastname: Paolo
mesh_terms: D017824:Bone Cysts, Aneurysmal / Q000150:complications / Q000473:pathology / Q000601:surgery; D005870:Giant Cell Tumors / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D019635:Neurosurgical Procedures; D016634:Radiosurgery; D013117:Spinal Cord Compression / Q000209:etiology / Q000473:pathology / Q000601:surgery; D013125:Spinal Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014402:Tuberous Sclerosis / Q000150:complications*; D055815:Young Adult