title: Persistence of primary MALT lymphoma of the urinary bladder after rituximab with CHOP chemotherapy and radiotherapy.
abstract: We present a case of a patient with primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue of the urinary bladder that persisted after chemotherapy, immunotherapy and radiotherapy.
  
  
  METHODS
  A 48-year-old male underwent a routine ultrasound examination. A tumour mass in the urinary bladder was found and a transurethral biopsy was performed. Pathohistological examination revealed MALT lymphoma. Results of computed tomographic scan, positron emission tomography scan and bone marrow biopsy defined the tumour as primary malignant lymphoma of the urinary bladder. The patient received eight cycles of chemo-immunotherapy (CHOP) and radiotherapy. Five months after therapy, there is a partial radiological remission, but with metabolic progression of the tumour. To our knowledge, this is the first case of MALT lymphoma of the urinary bladder with chemo-immunotherapy and radiotherapy resistance.
authors.affiliation: Department of Pathology, Dubrava University Hospital, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia. jasnabacalja@yahoo.com
authors.forename: Jasna
authors.initials: J
authors.lastname: Bacalja
authors.forename: Monika
authors.initials: M
authors.lastname: Ulamec
authors.forename: Duje
authors.initials: D
authors.lastname: Rako
authors.forename: Lidija
authors.initials: L
authors.lastname: Bošković
authors.forename: Davor
authors.initials: D
authors.lastname: Trnski
authors.forename: Eduard
authors.initials: E
authors.lastname: Vrdoljak
authors.forename: Božo
authors.initials: B
authors.lastname: Krušlin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011241:Prednisone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: CHOP; MALT lymphoma; chemotherapy; rituximab; urinary bladder