title: Effects of glycemia on immediate complications following CABG.
abstract: OBJECTIVE
  We investigated the relationship between postoperative glucose levels (days 1 through 3) and immediate outcomes in patients who underwent isolated coronary artery bypass grafting (CABG).
  
  
  METHODS
  We conducted a retrospective study of 2,558 consecutive patients who had isolated CABG. Patients were stratified into 3 groups based on their pre-operative mortality risk (MR), using Society of Thoracic Surgeons' criteria. Average glucose levels for the first 3 days following surgery were determined. Glucose levels for each group were divided into quartiles and related to relevant outcomes. Odds ratios assessing changes in outcomes as functions of increased glucose exposure were determined for postoperative days 1, 2, and 3 and for postoperative days 1 and 2 and 1 through 3.
  
  
  RESULTS
  The number of patients in each MR group (1 through 3; low, medium, and high) was 1,233, 852, and 473, respectively. Mean ± SD quartile glucose levels for days 1 and 2 were 133 ± 8.2, 150.4 ± 4.7, 167.2 ± 6.89, and 205.9 ± 24.9 mg/dL. The proportion of patients with a glucose level <70 mg/dL was 6.4%, <60 mg/dL was 2.7%, and <50 mg/dL was 1.1%. The most consistent and significant correlations between glucose quartiles and outcomes were observed for MR group 1, and they were most significant for the first 2 days following surgery. Glycemic control was not correlated with mortality, but it was correlated with total complications.
  
  
  CONCLUSIONS
  Hyperglycemia during the first two days after CABG adversely affected total complications in patients who were in the low and medium MR groups, but it did not significantly affect hospital mortality.
authors.affiliation: St. Luke's Episcopal Hospital Baylor College of Medicine.
authors.forename: Glenn R
authors.initials: GR
authors.lastname: Cunningham
authors.forename: Daoud
authors.initials: D
authors.lastname: Daoud
authors.forename: Susan
authors.initials: S
authors.lastname: Baimbridge
authors.forename: Charles
authors.initials: C
authors.lastname: Baimbridge
authors.forename: Shadi
authors.initials: S
authors.lastname: Abdelnour
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001026:Coronary Artery Bypass / Q000379:methods*; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011183:Postoperative Complications / Q000453:epidemiology / Q000378:metabolism*; D011184:Postoperative Period; D012189:Retrospective Studies; D012306:Risk; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin