title: [Features of clinical manifestations of the globe, adnexal and orbital sarcoidosis].
abstract: 86 patients with verified diagnosis of sarcoidosis with globe, adnexa and orbit manifestations were observed. The age of the patients ranged from 21 to 43 years old (average 35,1+/-1,2 years), among them 25 males and 61 females with disease duration from 1 month till 12 years and 15 years follow-up. The study is based on different variants of globe, adnexal and orbital sarcoidosis. In our practice we observed sarcoidosis as a combination of several manifestations simultaneously. In 32 patients of 38 patients examined HLA-B-7, B-8, DR-2, DR-3, DR-15 were detected, that confirms genetic predisposition to sarcoidosis and determines the course of the disease. In 27 patients cellular and humoral immunity disbalance was found, that confirms the immune etiology of sarcoidosis as well. However the treatment of patients was pathogenic as the etiology of sarcoidosis is still unknown.
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Razumova
authors.forename: O K
authors.initials: OK
authors.lastname: Vorob'eva
authors.forename: T N
authors.initials: TN
authors.lastname: Safonova
authors.forename: N L
authors.initials: NL
authors.lastname: Sheremet
authors.forename: O V
authors.initials: OV
authors.lastname: Éksarenko
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003941:Diagnostic Techniques, Ophthalmological; D004333:Drug Administration Routes; D005128:Eye Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D005260:Female; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000097:blood; D006801:Humans; D007765:Lacrimal Apparatus / Q000378:metabolism; D008297:Male; D009900:Optic Nerve / Q000503:physiopathology; D011379:Prognosis; D011859:Radiography; D012171:Retinal Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology; D012507:Sarcoidosis / Q000150:complications / Q000235:genetics / Q000276:immunology / Q000628:therapy; D016896:Treatment Outcome; D014463:Ultrasonography; D014602:Uvea / Q000000981:diagnostic imaging
chemical_list: D000893:Anti-Inflammatory Agents; D015235:HLA-B Antigens