title: Microwave endometrial ablation for endometrial protection in women with breast cancer on adjuvant tamoxifen.
abstract: OBJECTIVE
  The purpose of the current study was to determine the effectiveness of microwave endometrial ablation (MEA) in inhibiting the proliferative response of the endometrium in women with breast cancer who are treated with tamoxifen.
  
  
  METHODS
  In the before-after study, we treated 31 postmenopausal patients who had received adjuvant tamoxifen for 1 year or more with MEA, the endometrial changes were compared before and after MEA.
  
  
  RESULTS
  After MEA, the thickness of the uterine lining was decreased significantly. No patient had recurrent endometrial polyps or abnormal vaginal bleeding during the follow-up period.
  
  
  CONCLUSIONS
  MEA had a protective action against the uterine effects of tamoxifen for postmenopausal patients. MEA is a safe and effective minimally invasive treatment method for breast cancer patients treated with tamoxifen.
authors.affiliation: Department of Gynecology, The Second Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.
authors.forename: Yunshan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yang
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D055356:Endometrial Ablation Techniques / Q000009:adverse effects; D004714:Endometrial Hyperplasia / Q000139:chemically induced / Q000517:prevention & control / Q000601:surgery; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008872:Microwaves / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects* / Q000627:therapeutic use; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen
keywords: endometrium; microwave endometrial ablation; tamoxifen