title: Mood disorders in youth: exercise, light therapy, and pharmacologic complementary and integrative approaches.
abstract: The therapeutic value of physical exercise, bright light therapy and dawn simulation, and several pharmacologic treatments, including hypericum (St. John's wort), S-adenosylmethionine, and 5-hydroxytryptophan, are reviewed, with a focus on their use for treating major depressive disorder in children and adolescents and also for alleviating depressed mood in the general (nonclinical) population of youth. For each treatment discussed, all published randomized, double-blind, placebo-controlled trials are summarized, along with some additional selected studies. Nutritional psychopharmacology and several other approaches to treating depression will be presented in an upcoming volume in the Child and Adolescent Psychiatric Clinics of North America.
authors.affiliation: Child and Adolescent Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA. ChasPopper@harvard.edu
authors.forename: Charles W
authors.initials: CW
authors.lastname: Popper
mesh_terms: D006916:5-Hydroxytryptophan / Q000627:therapeutic use; D000293:Adolescent; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D002230:Carbidopa / Q000627:therapeutic use; D002648:Child; D000529:Complementary Therapies / Q000379:methods*; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000628:therapy*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005081:Exercise Therapy; D006801:Humans; D020902:Hypericum; D055048:Integrative Medicine / Q000379:methods*; D019964:Mood Disorders / Q000628:therapy; D010789:Phototherapy; D008517:Phytotherapy / Q000379:methods; D012436:S-Adenosylmethionine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D004791:Enzyme Inhibitors; D012436:S-Adenosylmethionine; D006916:5-Hydroxytryptophan; D002230:Carbidopa