title: Expression levels of 10 candidate genes in lung tissue of vaccinated and TB-infected cynomolgus macaques.
abstract: The expression of ten tuberculosis candidate genes in lung and lymph nodes of cynomolgus macaques vaccinated and experimentally infected with Mycobacterium tuberculosis (Mtb) was quantified. The expression of TNFα, IL10, IL1β, TLR4, IL17, IL6, IL12, and iNOS in the lungs of vaccinated animals was higher than that of non-vaccinated animals.
authors.affiliation: Graduate Group in Comparative Pathology, University of California, Davis, CA 95616, USA. mroodgar@ucdavis.edu
authors.forename: Morteza
authors.initials: M
authors.lastname: Roodgar
authors.forename: Andrew
authors.initials: A
authors.lastname: Lackner
authors.forename: Deepak
authors.initials: D
authors.lastname: Kaushal
authors.forename: Sumathi
authors.initials: S
authors.lastname: Sankaran
authors.forename: Satya
authors.initials: S
authors.lastname: Dandekar
authors.forename: Jessica Satkoski
authors.initials: JS
authors.lastname: Trask
authors.forename: Christiana
authors.initials: C
authors.lastname: Drake
authors.forename: David Glenn
authors.initials: DG
authors.lastname: Smith
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D018076:DNA, Complementary / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D008168:Lung / Q000276:immunology / Q000382:microbiology; D008198:Lymph Nodes / Q000276:immunology; D008252:Macaca fascicularis; D009169:Mycobacterium tuberculosis / Q000502:physiology; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology
chemical_list: D001500:BCG Vaccine; D016207:Cytokines; D018076:DNA, Complementary; D012333:RNA, Messenger; D051193:Toll-Like Receptors; D052247:Nitric Oxide Synthase Type II