title: Bivalirudin for treatment of aortic valve thrombosis after left ventricular assist device implantation.
abstract: Ventricular assist devices are increasingly being used for mechanical support in patients with advanced heart failure. However, thromboembolism remains a leading cause of mortality in this population. We describe the successful treatment of native aortic valve thrombosis with bivalirudin in a patient with factor V Leiden mutation, who had undergone left ventricular assist device implantation, preventing the need for further surgical intervention.
authors.affiliation: Department of Heart Failure and Transplant, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas 77030, USA.
authors.forename: Sinan H
authors.initials: SH
authors.lastname: Sarsam
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Civitello
authors.forename: Enoch E
authors.initials: EE
authors.lastname: Agunanne
authors.forename: Reynolds M
authors.initials: RM
authors.lastname: Delgado
mesh_terms: D000991:Antithrombins / Q000627:therapeutic use*; D001021:Aortic Valve; D000082882:Bicuspid Aortic Valve Disease; D003328:Coronary Thrombosis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006330:Heart Defects, Congenital / Q000188:drug therapy* / Q000209:etiology; D006349:Heart Valve Diseases / Q000188:drug therapy* / Q000209:etiology; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006629:Hirudins; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000991:Antithrombins; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C074619:bivalirudin