title: Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group.
abstract: A removable protecting group has been identified that allows the products of widely-used cross dehydrogenative couplings to be synthetically elaborated. The method can be used with enantiopure amines with no loss of enantiomeric excess. The methodology is exemplified by a new synthesis of enantiopure praziquantel, the drug used in the treatment of millions of people suffering from the neglected tropical disease, schistosomiasis.
authors.affiliation: School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Althea S-K
authors.initials: AS
authors.lastname: Tsang
authors.forename: Katrin
authors.initials: K
authors.lastname: Ingram
authors.forename: Jennifer
authors.initials: J
authors.lastname: Keiser
authors.forename: D Brynn
authors.initials: DB
authors.lastname: Hibbert
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Todd
mesh_terms: D000588:Amines / Q000737:chemistry*; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D015394:Molecular Structure; D011223:Praziquantel / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D000871:Anthelmintics; D011223:Praziquantel