title: Selective C(sp2)-C(sp) bond cleavage: the nitrogenation of alkynes to amides.
abstract: Breakthrough: A novel catalyzed direct highly selective C(sp2)-C(sp) bond functionalization of alkynes to amides has been developed. Nitrogenation is achieved by the highly selective C(sp2)-C(sp) bond cleavage of aryl-substituted alkynes. The oxidant-free and mild conditions and wide substrate scope make this method very practical.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Qin
authors.forename: Peng
authors.initials: P
authors.lastname: Feng
authors.forename: Yang
authors.initials: Y
authors.lastname: Ou
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.forename: Teng
authors.initials: T
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000577:Amides; D016877:Oxidants; D009584:Nitrogen
keywords: CC bond cleavage; alkynes; amides; gold; rearrangement