title: Melatonin improves liver function in benzene-treated rats.
abstract: In this study, we investigated the beneficial effects of melatonin against benzene-induced liver function impairments in Wistar rats. After 30 days of treatment, it significantly lowered hepatosomatic indices, bilirubin, and hydroxyproline in male and female benzene-treated rats. Even though it did not influence aspartate aminotransferase, melatonin had beneficial effects on alanine aminotransferase and alkaline phosphatase. Our results suggest that melatonin is an effective modulator of liver function in benzene-treated rats thanks to its antioxidative properties.
authors.affiliation: Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Sharma
authors.forename: Suresh Vir Singh
authors.initials: SV
authors.lastname: Rana
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001554:Benzene; D001663:Bilirubin / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D007273:Injections, Intramuscular; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008550:Melatonin / Q000378:metabolism* / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000378:metabolism* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001554:Benzene; D008550:Melatonin; D001663:Bilirubin