title: Topical ophthalmic use of cyclosporin A for Splendore-Hoeppli phenomenon.
abstract: The Splendore-Hoeppli reaction is a rare phenomenon characterised by the formation of eosinophilic material around infectious or non-infectious agents. A 33-year-old patient with persistent Splendore-Hoeppli phenomenon was previously treated with topical steroids but this resulted in a rise in intraocular pressure. The patient was treated with topical cyclosporin A one per cent twice daily as an alternative immunosuppression. After three weeks of treatment the patient had complete resolution of her conjunctival granuloma. This case report introduces cyclosporin A as a treatment option for the Splendore-Hoeppli phenomenon. This is a safe drug for long-term topical use in this condition.
authors.affiliation: City Eye Centre, Brisbane, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: McGrath
authors.forename: Kevin
authors.initials: K
authors.lastname: Whitehead
authors.forename: Graham A
authors.initials: GA
authors.lastname: Lee
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003229:Conjunctival Diseases / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage*; D004803:Eosinophilic Granuloma / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine
keywords: Splendore-Hoeppli; conjunctiva; cyclosporin; drugs