title: The prognostic value of miR-21 and miR-155 in non-small-cell lung cancer: a meta-analysis.
abstract: OBJECTIVE
  miR-21 and miR-155 have been implicated in the prognosis of non-small-cell lung cancer, but the results are controversial. To resolve this issue, we performed a meta-analysis on miR-21 and miR-155 and  non-small-cell lung cancer prognosis and lymphoid metastasis.
  
  
  METHODS
  Eligible data were extracted and the correlation between miR-21 and miR-155 and non-small-cell lung cancer survival was analyzed by calculating a pooled hazard ratio and sensitivity analysis. The heterogeneity was detected by Q statistic and I-squared statistic, and the publication bias was tested by funnel plots and Egger's test.
  
  
  RESULTS
  Nineteen studies were included. High miR-21 level (hazard ratio = 2.00, 95% confidence interval = 1.38-2.89, P = 0.000 for heterogeneity test, I(2) = 84.9%) and high miR-155 level (hazard ratio = 1.65, 95% confidence interval = 1.11-2.44, P = 0.004 for heterogeneity test, I(2) = 68.3%) were significantly associated with worse non-small-cell lung cancer survival. Furthermore, a high miR-21 level was associated with an increased risk of lymphoid infiltration for non-small-cell lung cancer (odds ratio = 1.93; 95% confidence interval = 1.31-2.85). Funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis.
  
  
  CONCLUSIONS
  This meta-analysis provides evidence that miR-21 and miR-155 are predicting factors for non-small-cell lung cancer prognosis and lymphoid infiltration.
authors.affiliation: 1Department of Microbiology, Harbin Medical University, Immunity and Infection, Pathogenic Biology Key Laboratory, Harbin, Heilongjiang Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jinyuan
authors.initials: J
authors.lastname: Li
authors.forename: Liping
authors.initials: L
authors.lastname: Tong
authors.forename: Jingwei
authors.initials: J
authors.lastname: Zhang
authors.forename: Aixia
authors.initials: A
authors.lastname: Zhai
authors.forename: Kun
authors.initials: K
authors.lastname: Xu
authors.forename: Lanlan
authors.initials: L
authors.lastname: Wei
authors.forename: Ming
authors.initials: M
authors.lastname: Chu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D008207:Lymphatic Metastasis; D035683:MicroRNAs / Q000378:metabolism*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; C524942:MIRN155 microRNA, human; C524940:MIRN21 microRNA, human; D035683:MicroRNAs
keywords: NSCLC; meta-analysis; miR-155; miR-21; prognosis