title: Temporal variation of Trypanosoma cruzi discrete typing units in asymptomatic Chagas disease patients.
abstract: Chagas disease caused by Trypanosoma cruzi is a public health problem in Latin America. This parasite displays a high genetic diversity evidenced in six Discrete Typing Units (DTUs) namely TcI-TcVI. The aim of this study was to observe the temporal variation of the DTUs in asymptomatic patients at three different times (10 days interval). The results showed that intermittence is the rule in the bloodstream of Chagas disease patients. The patients showed different detectable DTUs with short time intervals, which favors the clonal histiotropic model and the multiclonality structure of this parasite.
authors.affiliation: Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá, Colombia.
authors.forename: Laura V
authors.initials: LV
authors.lastname: Sánchez
authors.forename: Diana C
authors.initials: DC
authors.lastname: Bautista
authors.forename: Andrés F
authors.initials: AF
authors.lastname: Corredor
authors.forename: Victor M
authors.initials: VM
authors.lastname: Herrera
authors.forename: Luz X
authors.initials: LX
authors.lastname: Martinez
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Villar
authors.forename: Juan David
authors.initials: JD
authors.lastname: Ramírez
mesh_terms: D058070:Asymptomatic Diseases; D014355:Chagas Disease / Q000469:parasitology*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007843:Latin America; D013997:Time Factors; D014349:Trypanosoma cruzi / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification
keywords: Chagas disease; Discrete typing unit; Multiclonality; SL-IR; Temporal distribution