title: Scalable manufacture of built-to-order nanomedicine: spray-assisted layer-by-layer functionalization of PRINT nanoparticles.
abstract: Scalable methods, PRINT particle fabrication, and spray-assisted Layer-by-Layer deposition are combined to generate uniform and functional nanotechnologies with precise control over composition, size, shape, and surface functionality. A modular and tunable approach towards design of built-to-order nanoparticle systems, spray coating on PRINT particles is demonstrated to achieve technologies capable of targeted interactions with cancer cells for applications in drug delivery.
authors.affiliation: Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Morton
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Herlihy
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Shopsowitz
authors.forename: Zhou J
authors.initials: ZJ
authors.lastname: Deng
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Chu
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Bowerman
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Desimone
authors.forename: Paula T
authors.initials: PT
authors.lastname: Hammond
mesh_terms: D002232:Carbocyanines / Q000737:chemistry; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D018625:Microscopy, Atomic Force; D018613:Microscopy, Confocal; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011107:Polylysine / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry
chemical_list: D002232:Carbocyanines; D004337:Drug Carriers; C085321:cyanine dye 5; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011107:Polylysine; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011142:Polyvinyl Alcohol
keywords: core/shell nanoparticles; nanoimprinting; nanomedicine; thin films