title: Double Negative (DN) [CD3⁺CD4⁻CD8⁻] T cells correlate with disease progression during HIV infection.
abstract: Although double negative T (DNT) cells (CD3⁺CD4⁻CD8⁻) share some characteristics with T regulatory cells, the relationship between DNT cells and disease progression in HIV infection is unclear. In this study, we analyzed the relationship between DNT cells and disease progression during the first 2 years of HIV infection. We found that DNT cell numbers tended to decrease with disease progression. There was a positive correlation between DNT cells and CD4 counts. The DNT cell numbers were significantly lower in the high viral load group compared with the low viral load group. Therefore, we conclude that DNT cells correlated with disease progression in HIV infection. These data provide valuable information for further understanding of the role of DNT cells during HIV infection.
authors.affiliation: Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liang
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Jiao
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Huang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Tang
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
mesh_terms: D000328:Adult; D017252:CD3 Complex / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism; D018791:CD4 Lymphocyte Count; D016827:CD8 Antigens / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D019562:Viral Load / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens