title: Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs.
abstract: BACKGROUND
  Adipose-derived mesenchymal stem cell (ADMSC) therapy in regenerative medicine is a rapidly growing area of research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify the efficacy of different therapeutic strategies for the treatment of OA in dogs, but never with AD-MSC.The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA.
  
  
  RESULTS
  Eight lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved after treatment of the OA groups, reaching 53.02% and 14.84% of body weight, respectively, at day 180, compared with only 43.56% and 12.16% at day 0.
  
  
  CONCLUSIONS
  This study objectively demonstrated that intraarticular ADMSC therapy resulted in reduced lameness due to OA.
authors.affiliation: Department of Animal Pathology, Faculty of Veterinary Medicine, Universidad de Las Palmas de Gran Canaria, Trasmontaña S/N, Arucas 35413 Las Palmas, Spain. jvilar@dpat.ulpgc.es
authors.forename: Jose M
authors.initials: JM
authors.lastname: Vilar
authors.forename: Manuel
authors.initials: M
authors.lastname: Morales
authors.forename: Angelo
authors.initials: A
authors.lastname: Santana
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Spinella
authors.forename: Mónica
authors.initials: M
authors.lastname: Rubio
authors.forename: Belen
authors.initials: B
authors.lastname: Cuervo
authors.forename: Ramón
authors.initials: R
authors.lastname: Cugat
authors.forename: Jose M
authors.initials: JM
authors.lastname: Carrillo
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000637:transplantation; D000818:Animals; D004283:Dog Diseases / Q000503:physiopathology / Q000628:therapy*; D004285:Dogs; D005260:Female; D005684:Gait / Q000502:physiology; D007270:Injections, Intra-Articular / Q000662:veterinary; D007794:Lameness, Animal / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary*; D010003:Osteoarthritis / Q000150:complications / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D053657:Platelet-Rich Plasma / Q000502:physiology; D016896:Treatment Outcome; D016474:Weight-Bearing / Q000502:physiology