title: Three new glucosides from a cold-adapted fungal strain Mucor sp.
abstract: Two new naphthaline glucosides, 2-hydroxy-3-methoxy-8-methyl-1-O-β-d-glucopyranosylnaphthaline (1) and 1-hydroxy-3-methoxy-8-methyl-2-O-β-d-glucopyranosylnaphthaline (2), together with one new isocoumarin glucoside, 3-(3,3-dichloro-2-hydroxylpropyl)-6-methoxy-8-O-β-d-glucopyranosyl-1H-isochromen-1-one (3), were isolated from a cold-adapted fungal strain Mucor sp. (No. XJ07027-5). Their structures were characterized by detailed analyses of IR, MS, 1D- and 2D-NMR spectra. Among them, 2 showed moderate cytotoxic activity against five tumor cells (A-549, HL-60, MCF-7, SMMC-7721, and SW480).
authors.affiliation: a Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , 510632 , China.
authors.forename: Chun-Chi
authors.initials: CC
authors.lastname: Feng
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Li
authors.forename: Jin-Shan
authors.initials: JS
authors.lastname: Tang
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D003080:Cold Temperature; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D061986:MCF-7 Cells; D015394:Molecular Structure; D009089:Mucor / Q000737:chemistry*; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: C585615:1-hydroxy-3-methoxy-8-methyl-2-O-beta-D-glucopyranosylnaphthaline; C585614:2-hydroxy-3-methoxy-8-methyl-1-O-beta-D-glucopyranosylnaphthaline; C585613:3-(3,3-dichloro-2-hydroxylpropyl)-6-methoxy-8-O-beta-D-glucopyranosyl-1H-isochromen-1-one; D000970:Antineoplastic Agents; D005960:Glucosides; D049934:Isocoumarins; D009281:Naphthalenes