title: Supporting smoking cessation in chronic obstructive pulmonary disease with behavioral intervention: a randomized controlled trial.
abstract: BACKGROUND
  Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD). But a fewer smoking cessation measures were conducted in communities for smokers with COPD in China. The aim of our study was to assess the preventive effects of behavioral interventions for smoking cessation and potential impact factors in smokers with COPD in China.
  
  
  METHODS
  In a randomised controlled smoking cessation trial 3562 patients with COPD who were current smoker were allocated to intervention group received behavioral intervention and control group received the usual care for two years. The primary efficacy endpoint was the complete and continuous abstinence from smoking from the beginning of month 24 to the end of month 30. Participants were followed up at month 48.
  
  
  RESULTS
  Continuous smoking abstinence rates from month 24 to 30 were significantly higher in participants receiving behavioral intervention than in those receiving usual care (46.4% vs 3.4%, p < 0.001). Continuous abstinence rates from months 24 to 36 (45.8% vs 4.0%) and months 24 to 48 (44.3% vs 5.1%) were also higher in participants receiving behavioral intervention than in those control group. Family members or family physicians/nurses smoking were first identified to influence smoking cessation.
  
  
  CONCLUSIONS
  Behavioral intervention doubled the smoking cessation rate in patients with COPD and was complied well by the general practitioners. The family members and family physicians/nurses smoking were the main risk factors for smoking cessation.
  
  
  BACKGROUND
  Chinese Clinical Trials Registration (ChiCTR-TRC-12001958).
authors.affiliation: The Xuzhou Center for Disease Control and Prevention, 142 West Erhuan Road, Xuzhou City, Jiangsu Province, People's Republic of China 221006. loupeian2004@yahoo.com.cn
authors.forename: Peian
authors.initials: P
authors.lastname: Lou
authors.forename: Yanan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Peipei
authors.initials: P
authors.lastname: Chen
authors.forename: Pan
authors.initials: P
authors.lastname: Zhang
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Yu
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Hongmin
authors.initials: H
authors.lastname: Wu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015397:Program Evaluation; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000517:prevention & control*; D012424:Rural Population; D012907:Smoking / Q000628:therapy*; D016540:Smoking Cessation / Q000191:economics / Q000706:statistics & numerical data*; D012959:Socioeconomic Factors; D013997:Time Factors; D016896:Treatment Outcome