title: The role of type 2 innate lymphoid cells in asthma.
abstract: Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype, characterized by Th2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes that require innate rather than adaptive immunity. These innate pathways to asthma involve macrophages, neutrophils, as well as ILCs, newly described cell types that produce a variety of cytokines, including IL-5 and IL-13. We review the recent data regarding ILCs and their role in asthma.
authors.affiliation: 1.Harvard Medical School, Karp Labs, Room 10127, One Blackfan Circle, Boston, MA 02115, USA. dale.umetsu@childrens.harvard.edu; Ya-Jen Chang, Academia Sinica, 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan. E-mail: yajchang@ibms.sinica.edu.tw.
authors.forename: Ya-Jen
authors.initials: YJ
authors.lastname: Chang
authors.forename: Rosemarie H
authors.initials: RH
authors.lastname: DeKruyff
authors.forename: Dale T
authors.initials: DT
authors.lastname: Umetsu
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000628:therapy; D001424:Bacterial Infections / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007251:Influenza, Human / Q000276:immunology; D018793:Interleukin-13 / Q000096:biosynthesis; D008168:Lung / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D018123:Receptors, Interleukin / Q000502:physiology
chemical_list: D000485:Allergens; D018793:Interleukin-13; D018123:Receptors, Interleukin
keywords: NKT cells; airway hyper-reactivity; allergy; influenza