title: 18F sodium fluoride PET/CT detects osseous metastases from breast cancer missed on FDG PET/CT with marrow rebound.
abstract: Intense FDG uptake by bone marrow following recent chemotherapy limits evaluation for osseous metastases. The impact of marrow rebound on accuracy of (18)F-fluoride PET/CT is unclear. A 73-year-old woman with breast cancer presented for restaging FDG PET/CT, which showed intense activity throughout almost the entire axial skeleton and no osseous metastases. An (18)F-fluoride PET/CT performed 7 days later identified multiple osseous metastases in the spine, ribs, and pelvis. This case demonstrates that (18)F-fluoride PET/CT should be considered for the evaluation of osseous metastases in patients with rebound marrow uptake on FDG PET/CT.
authors.affiliation: Department of Medical Imaging, The University of Arizona Medical Center, Tucson, AZ, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Avery
authors.forename: Phillip H
authors.initials: PH
authors.lastname: Kuo
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D010006:Osteoblasts / Q000473:pathology; D049268:Positron-Emission Tomography; D012969:Sodium Fluoride; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D012969:Sodium Fluoride