title: Performance of rapid tests and algorithms for HIV screening in Abidjan, Ivory Coast.
abstract: Seven rapid diagnosis tests (RDTs) of HIV were evaluated by a panel group who collected serum samples from patients in Abidjan (HIV-1 = 203, HIV-2 = 25, HIV-dual = 25, HIV = 305). Kit performances were recorded after the reference techniques (enzyme-linked immunosorbent assay). The following RDTs showed a sensitivity of 100% and a specificity higher than 99%: Determine, Oraquick, SD Bioline, BCP, and Stat-Pak. These kits were used to establish infection screening strategies. The combination with 2 or 3 of these tests in series or parallel algorithms showed that series combinations with 2 tests (Oraquick and Bioline) and 3 tests (Determine, BCP, and Stat-Pak) gave the best performances (sensitivity, specificity, positive predictive value, and negative predictive value of 100%). However, the combination with 2 tests appeared to be more onerous than the combination with 3 tests. The combination with Determine, BCP, and Stat-Pak tests serving as a tiebreaker could be an alternative to the HIV/AIDS serological screening in Abidjan.
authors.affiliation: Département de Bactériologie-Virologie, UFR SPB, Boulevard de l'Université 22, BP 450, Abidjan.
authors.forename: Y G
authors.initials: YG
authors.lastname: Loukou
authors.forename: M A
authors.initials: MA
authors.lastname: Cabran
authors.forename: Zinzendorf Nanga
authors.initials: ZN
authors.lastname: Yessé
authors.forename: B M O
authors.initials: BM
authors.lastname: Adouko
authors.forename: S J
authors.initials: SJ
authors.lastname: Lathro
authors.forename: K B T
authors.initials: KB
authors.lastname: Agbessi-Kouassi
mesh_terms: D015492:AIDS Serodiagnosis / Q000191:economics / Q000379:methods; D000465:Algorithms; D007560:Cote d'Ivoire; D015658:HIV Infections / Q000175:diagnosis*; D006801:Humans; D008403:Mass Screening / Q000191:economics / Q000379:methods; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
chemical_list: D011933:Reagent Kits, Diagnostic
keywords: HIV; performance; strategy; testing