title: Assessment of myometrial concentrations of oestrogen and progesterone receptors in the lower uterine segment of full-term pregnancies in presence or absence of labour.
abstract: OBJECTIVE
  To assess the concentration of progesterone (PRs) and oestrogen (ORs) receptors of myometrium of full-term pregnant women in the myometrium of lower segment of the uterus in relationship with presence or absence of labour.
  
  
  METHODS
  This was a cross-sectional prospective study with 21 pregnant women, being 6 in labour (Group I) and 15 without labour (Group II). The biopsy of myometrium was realized during caesarian section, and the excised tissue was stained using immunohistochemical techniques for the quantification of the receptors, and with the aid of image-analysis software, the numbers of receptors for each hormone were determined spectrophotometrically. The Mann-Whitney test was used to compare the pregnant women in each study group with respect to the numbers of ORs and PRs. The Wilcoxon test was used to compare the concentration of ORs and PRs in each group separately.
  
  
  RESULTS
  The mean of gestational age was 39 weeks, (range, 37 to 41 weeks). The medians of PRs and ORs in pregnant women in labour (Group I) were 29.3 (range, 24.6-30.2) and 32.3 (range, 22.9-49.0), respectively. The medians of PRs and ORs in pregnant women without labour (Group II) were 43.6 (range, 23.6-70) and 43.9 (range, 18.3-62.6), respectively. We did not observe significant differences of the number of ORs and PRs in both groups (P = 0.13 and 0.37, resp.). The number of ORs was statistically more than that of PRs in Group II (Z calculated = 16.00).
  
  
  CONCLUSIONS
  The concentrations of PRs and ORs were similar in the myometrium of the lower uterine segment of pregnant women during and without labour, but the concentration of ORs was more than that of PRs in the myometrium of the lower uterine segment of pregnant women without labour.
authors.affiliation: Department of Obstetrics, Federal University of São Paulo (UNIFESP), Rua Carlos Weber, 956 Apartment 113 Visage, Vila Leopoldina, 05303-000 São Paulo, SP, Brazil.
authors.forename: Joana Soares
authors.initials: JS
authors.lastname: de Arruda
authors.forename: Edward
authors.initials: E
authors.lastname: Araujo Júnior
authors.forename: Manuel de Jesus
authors.initials: Mde J
authors.lastname: Simões
authors.forename: Luiz
authors.initials: L
authors.lastname: Kulay Júnior
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000378:metabolism*; D009215:Myometrium / Q000737:chemistry*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone