title: SIMIBI twins in protein targeting and localization.
abstract: Signal recognition particle, MinD and BioD (SIMIBI)-type nucleoside triphosphate-binding proteins are an ancient subfamily of nucleotide-binding proteins that serve in a wide range of cellular processes. Notably, this class comprises dimeric ATPases as well as GTPases (SIMIBI 'twins') and a subset of SIMIBI-type proteins, including SRP GTPases, MinD-type ATPases and the Get3 ATPase, is essential to protein targeting and localization. Here, we define common mechanistic principles and differences for these SIMIBI proteins.
authors.affiliation: Biochemie-Zentrum der Universität Heidelberg, INF328, Heidelberg, Germany. gert.bange@synmikro.uni-marburg.de
authors.forename: Gert
authors.initials: G
authors.lastname: Bange
authors.forename: Irmgard
authors.initials: I
authors.lastname: Sinning
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry* / Q000378:metabolism; D001419:Bacteria / Q000737:chemistry / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D055503:Protein Multimerization; D021381:Protein Transport
chemical_list: D002352:Carrier Proteins; D000251:Adenosine Triphosphatases; D020558:GTP Phosphohydrolases