title: New wrinkles in old receptors: core fucosylation is yet another target to inhibit TGF-β signaling.
abstract: Shen et al. exploit glycobiology to dampen transforming growth factor-β (TGF-β) signaling and ameliorate renal fibrosis after ureteral obstruction. Core fucosylation of N-linked oligosaccharides in TGF-β receptors is required for receptor function. Adenoviruses expressing Fut8-fucosyl transferase-shRNA inhibited receptor fucosylation, decreased tubule TGF-β signaling, and reduced fibrosis. Fut8-shRNA interferes with core fucosylation of other receptors also. Regardless, this first attempt to capitalize on a new aspect of TGF-β receptor function provides a basis for further research.
authors.affiliation: Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA. venkatachal@uthscsa.edu
authors.forename: Manjeri A
authors.initials: MA
authors.lastname: Venkatachalam
authors.forename: Joel M
authors.initials: JM
authors.lastname: Weinberg
mesh_terms: D000818:Animals; D005643:Fucose / Q000378:metabolism*; D005647:Fucosyltransferases / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000517:prevention & control*; D008297:Male; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; C508962:Tgfb1 protein, rat; D053773:Transforming Growth Factor beta1; D005643:Fucose; D005647:Fucosyltransferases; C020559:Glycoprotein 6-alpha-L-fucosyltransferase