title: Secretoglobin 1A member 1 (SCGB1A1) +38A/G polymorphism is associated with asthma risk: a meta-analysis.
abstract: BACKGROUND
  Epidemiological studies have evaluated the association between Secretoglobin 1A member 1 (SCGB1A1) +38A/G polymorphism and asthma, but the results remain inconclusive. The aim of this study was to perform a meta-analysis to investigate a more authentic association between SCGB1A1 +38A/G polymorphism and asthma.
  
  
  METHODS
  Published literature from PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random or fixed-effect model according the between-study heterogeneity.
  
  
  RESULTS
  A total of 19 case-control studies in 18 articles were included in the meta-analysis, including 3191 cases and 5182 controls. We found that SCGB1A1 +38A/G polymorphism was associated with a significantly increased risk of asthma risk when all studies were pooled in a dominant model (OR=1.29; 95% CI 1.08-1.54; P=0.005). The cumulative meta-analysis and sensitivity analysis further strengthened the stability of the result. Furthermore, publication bias was not detected.
  
  
  CONCLUSIONS
  This study suggested that SCGB1A1 +38A/G polymorphism was a risk factor for asthma. Further large and well-designed studies are needed to confirm this association.
authors.affiliation: Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. niewei-1001@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Nie
authors.forename: Cheng
authors.initials: C
authors.lastname: Xue
authors.forename: Jiquan
authors.initials: J
authors.lastname: Chen
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Xiu
mesh_terms: D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014598:Uteroglobin / Q000235:genetics*
chemical_list: C556389:SCGB1A1 protein, human; D014598:Uteroglobin
keywords: Asthma; CI; HWE; Hardy–Weinberg equilibrium; Meta-analysis; OR; Polymorphism; SCGB1A1; Secretoglobin 1A member 1; confidence interval; odds ratio