title: Suicidal behavior in dementia: a special risk in semantic dementia.
abstract: BACKGROUND
  Some studies report a low suicide risk in general dementia and in Alzheimer's disease (AD).
  
  
  OBJECTIVE
  To evaluate suicidal behavior among patients with semantic dementia (SD), a disorder that impairs semantic knowledge.
  
  
  METHODS
  We reviewed the presence of active suicidal behavior and related factors among 25 patients with SD compared to 111 age-matched patients with early-onset AD.
  
  
  RESULTS
  In all, 5 (20%) patients with SD had suicidal behavior (2 successfully killed themselves) compared to 1 (0.9%) with AD (P < .001). There was significantly more depression and greater premorbid history of suicidal behavior among the patients with SD compared to those with AD. Among the patients with SD, those with suicidal behavior, compared to those without, had more depression and greater insight into their deficits.
  
  
  CONCLUSIONS
  Patients with SD are at special risk of committing suicide, particularly if they have depression and preserved insight. Possible mechanisms include an impaired sense of semantic competence with increased impulsivity.
authors.affiliation: Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors.forename: Valeriy
authors.initials: V
authors.lastname: Sabodash
authors.forename: Mario F
authors.initials: MF
authors.lastname: Mendez
authors.forename: Sylvia
authors.initials: S
authors.lastname: Fong
authors.forename: Julia J
authors.initials: JJ
authors.lastname: Hsiao
mesh_terms: D017668:Age of Onset; D000368:Aged; D018888:Aphasia, Primary Progressive / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006801:Humans; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012307:Risk Factors; D012660:Semantics; D059020:Suicidal Ideation; D013405:Suicide / Q000523:psychology* / Q000706:statistics & numerical data*; D015899:Tomography, Emission-Computed, Single-Photon
keywords: Alzheimer’s disease; dementia; depression; primary progressive aphasia; semantic dementia; suicidal; suicide