title: Highly cross-linked and biocompatible polyphosphazene-coated superparamagnetic Fe3O4 nanoparticles for magnetic resonance imaging.
abstract: Highly cross-linked and biocompatible poly(cyclotriphosphazene-co-4,4'-sulfonyldiphenol) (PZS) were used to directly coat hydrophilic superparamagnetic Fe3O4 nanoparticles by a facile but effective one-pot polycondensation. The obtained core-shell Fe3O4@PZS nanohybrids were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction spectra. Interesting, the size and T2 relaxivity of Fe3O4@PZS increased with increasing the mass ratio of Fe3O4 to PZS. All these nanohybrids could be internalized by HeLa cells but show negligible cytotoxicity. The PZS layer slowly degraded into less dangerous forms such as 4,4'-sulfonyldiphenol, phosphate and ammonia at neutral or acid atmosphere. Considering their excellent water dispersibility, colloidal and chemical stability, magnetic manipulation, and magnetic resonance imaging (MRI) properties, Fe3O4@PZS nanohybrids have great potential in MRI diagnosis of cancer.
authors.affiliation: School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Lingjie
authors.initials: L
authors.lastname: Meng
authors.forename: Lvye
authors.initials: L
authors.lastname: Niu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Lu
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000633:toxicity; D004355:Drug Stability; D006367:HeLa Cells; D006801:Humans; D060328:Magnetic Phenomena; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D058185:Magnetite Nanoparticles; D009943:Organophosphorus Compounds; D010636:Phenols; D011108:Polymers; C586567:poly(cyclotriphosphazene-co-4,4'-sulfonyldiphenol)