title: Thaixylomolins A-C: limonoids featuring two new motifs from the Thai Xylocarpus moluccensis.
abstract: Three limonoids named thaixylomolins A-C (1-3), featuring two new motifs, were isolated from the seeds of a Thai mangrove, Xylocarpus moluccensis. The absolute configurations of these limonoids were determined by extensive NMR investigations, single-crystal X-ray diffraction analysis, and circular-dichroism spectroscopy in combination with quantum-chemical calculations. Thaixylomolin B exhibited inhibitory activity against nitric oxide production in lipopolysaccharide and IFN-γ-induced RAW264.7 murine macrophages with an IC50 value of 84.3 μM.
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Min-Yi
authors.initials: MY
authors.lastname: Li
authors.forename: Torsten
authors.initials: T
authors.lastname: Bruhn
authors.forename: Félix Zongwe
authors.initials: FZ
authors.lastname: Katele
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xiao
authors.forename: Patchara
authors.initials: P
authors.lastname: Pedpradab
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Gerhard
authors.initials: G
authors.lastname: Bringmann
mesh_terms: D000818:Animals; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry* / Q000494:pharmacology*; D008264:Macrophages / Q000737:chemistry* / Q000187:drug effects*; D029582:Meliaceae / Q000737:chemistry* / Q000187:drug effects*; D014961:X-Ray Diffraction
chemical_list: D036701:Limonins; C586055:thaixylomolin A; C586056:thaixylomolin B; C586057:thaixylomolin C