title: Nitrofurantoin-Induced Granulomatous Interstitial Pneumonia.
abstract: Nitrofurantoin-induced lung toxicity is relatively common, but rare histologic patterns sometimes occur that may make diagnosis difficult. We present the case of a 69-year-old woman taking prophylactic nitrofurantoin for urinary tract infections, who developed granulomatous interstitial pneumonia. She improved with cessation of nitrofurantoin, without other therapy. To our knowledge, this is the fourth reported case of granulomatous interstitial pneumonia associated with nitrofurantoin, and the first to show complete resolution with cessation of the drug alone, without steroids. It is important to recognize that idiosyncratic reactions to nitrofurantoin can produce a wide spectrum of histologic patterns. Of these patterns, granulomatous interstitial pneumonia is a rarely evidenced manifestation (possibly because few cases undergo a confirmatory lung biopsy). Recognition of granulomatous interstitial pneumonia as a manifestation of nitrofurantoin toxicity can aid in early identification of the reaction and prompt withdrawal of the drug, both of which are essential to prevent long-term complications.
authors.affiliation: Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Sakata
authors.affiliation: Mayo Clinic, Rochester, MN, USA.
authors.forename: Brandon T
authors.initials: BT
authors.lastname: Larsen
authors.affiliation: Mayo Clinic, Rochester, MN, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Boland
authors.affiliation: Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Palen
authors.affiliation: Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Muhm
authors.affiliation: Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Helmers
authors.affiliation: Mayo Clinic, Scottsdale, AZ, USA tazelaar.henry@mayo.edu.
authors.forename: Henry D
authors.initials: HD
authors.lastname: Tazelaar
mesh_terms: D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D005260:Female; D006099:Granuloma / Q000139:chemically induced; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D009582:Nitrofurantoin / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin
keywords: granulomas; lung; nitrofurantoin; toxicity