title: Successful management of neonatal myocardial infarction with ECMO and intracoronary r-tPA lysis.
abstract: Acute myocardial infarction (MI) is a life-threatening condition rarely encountered in neonates. The patients usually present with sudden cardiogenic shock. Clinical management in neonates is extremely challenging. If treatment is delayed, the prognosis is dismal. We report on a 4-day-old full-term male newborn presenting with acute MI and cardiogenic shock secondary to proximal thromboembolic occlusion of the left descending coronary artery. Hemodynamic stabilization could only be achieved after extracorporeal membrane oxygenation (ECMO) support. Coronary artery patency restoration was performed by selective intracoronary lysis with recombinant tissue plasminogen activator (r-tPA). ECMO support could be discontinued and myocardial function recovered within 6 weeks. We discuss the potential etiologies of acute perinatal MI and the role of ECMO support in the immediate post-MI period. Prompt recognition, timely referral to a cardiac center with availability of specialized advanced treatment options, and management in an orchestrated interdisciplinary approach are crucial for achieving a good outcome.
authors.affiliation: Department of Cardiovascular Surgery, German Heart Center Munich, Technical University Munich, Munich, Germany.
authors.forename: Marcus-André
authors.initials: MA
authors.lastname: Deutsch
authors.forename: Julie
authors.initials: J
authors.lastname: Cleuziou
authors.forename: Christian
authors.initials: C
authors.lastname: Noebauer
authors.forename: Andreas
authors.initials: A
authors.lastname: Eicken
authors.forename: Manfred
authors.initials: M
authors.lastname: Vogt
authors.forename: Juergen
authors.initials: J
authors.lastname: Hoerer
authors.forename: Ruediger
authors.initials: R
authors.lastname: Lange
authors.forename: Christian
authors.initials: C
authors.lastname: Schreiber
mesh_terms: D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D003331:Coronary Vessels / Q000503:physiopathology; D004562:Electrocardiography; D015199:Extracorporeal Membrane Oxygenation; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage; D020127:Recovery of Function; D012307:Risk Factors; D012770:Shock, Cardiogenic / Q000209:etiology / Q000628:therapy; D015912:Thrombolytic Therapy; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome; D014654:Vascular Patency
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator
keywords: Extracorporeal Membrane Oxygenation; Neonatal Myocardial Infarction; Thrombolytic Therapy