title: Short- and long-term phasing of intraocular pressure in stable and progressive glaucoma.
abstract: OBJECTIVE
  To evaluate short- (ST) and long-term (LT) intraocular pressure (IOP) in patients with stable (SG) and progressive glaucoma (PG).
  
  
  METHODS
  Fifty-two patients with treated glaucoma received a baseline 24-hour IOP curve and, every 6 months for 2 years, office-hour curve plus visual field test. Based on field changes, they were divided into 24 SG and 28 PG. ST and LT IOP mean, peak and fluctuation (standard deviation of measurements) were calculated. Parameters determining progression were evaluated by logistic regression.
  
  
  RESULTS
  At ST, SG and PG, respectively, had mean IOP of 16.8 ± 2.2 and 15.3 ± 1.8 mm Hg; peak of 19.7 ± 3.3, 17.4 ± 2.3 mm Hg; fluctuation of 2.3 ± 1.2, and 1.6 ± 0.6 mm Hg. LT parameters did not change in SG, whereas a significant increase of mean (+1.0 ± 1.5 mm Hg, p = 0.05), peak (2.0 ± 2.4 mm Hg, p = 0.0002), and fluctuation (0.5 ± 1.1 mm Hg, p = 0.008) occurred in PG. Mean, peak, and fluctuation were correlated, except mean and fluctuation in the long term. Association with progression was shown for change in mean IOP between ST and LT, and ST peak.
  
  
  CONCLUSIONS
  SG and PG may show different IOP parameters when intensively measured at baseline and follow-up. Mean IOP change between ST and LT periods and ST peak were the parameters associated with progression.
authors.affiliation: Eye Clinic, Department of Medicine, Surgery and Odontology, Ospedale San Paolo, University of Milan, Milan, Italy. fogagnolopaolo@googlemail.com
authors.forename: Paolo
authors.initials: P
authors.lastname: Fogagnolo
authors.forename: Nicola
authors.initials: N
authors.lastname: Orzalesi
authors.forename: Marco
authors.initials: M
authors.lastname: Centofanti
authors.forename: Francesco
authors.initials: F
authors.lastname: Oddone
authors.forename: Gianluca
authors.initials: G
authors.lastname: Manni
authors.forename: Luca
authors.initials: L
authors.lastname: Rossetti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D014065:Tonometry, Ocular; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D000959:Antihypertensive Agents