title: The effect of a mouthrinse containing chlorine dioxide in the clinical reduction of volatile sulfur compounds.
abstract: This study sought to evaluate the clinical effect of a mouthrinse containing 0.3% chlorine dioxide (ClO2) in reducing oral volatile sulfur compounds (VSC). Halitosis was induced by L-cysteine in 11 volunteers, and 4 solutions were compared: a test solution containing 0.3% ClO2, 0.07% cetylpyridinium chloride (CPC), and 0.05% sodium fluoride; a placebo; a solution containing 0.05% CPC; and a control solution of 0.2% chlorhexidine gluconate (CHX). VSC levels were assessed using a Halimeter, and 6 measurements were made from baseline to 3 hours postrinse. The VSC reduction rate of the test mouthrinse was superior to the placebo and the CPC solution. There was no difference between the test solution and the CHX solution in VSC reduction rates immediately postrinse, or at 2 and 3 hours postrinse; both solutions were statistically superior to the placebo and the CPC solution.
authors.affiliation: Universidade do Estado do Rio de Janeiro, Brazil.
authors.forename: Leo Guimaraes
authors.initials: LG
authors.lastname: Soares
authors.forename: Roberto Luiz
authors.initials: RL
authors.lastname: Guaitolini
authors.forename: Sergio de Carvalho
authors.initials: Sde C
authors.lastname: Weyne
authors.forename: Marcio Eduardo Vieira
authors.initials: ME
authors.lastname: Falabella
authors.forename: Eduardo Muniz Barretto
authors.initials: EM
authors.lastname: Tinoco
authors.forename: Denise Gomes
authors.initials: DG
authors.lastname: da Silva
mesh_terms: D002594:Cetylpyridinium / Q000008:administration & dosage; D006209:Halitosis; D006801:Humans; D009067:Mouthwashes / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D013457:Sulfur Compounds
chemical_list: D009067:Mouthwashes; D013457:Sulfur Compounds; D012969:Sodium Fluoride; D002594:Cetylpyridinium
keywords: VSC; halitosis; mouthrinse; volatile sulfur compounds