title: [G4-quadruplexes and genome instability].
abstract: A comparative analysis in silico of distribution of nucleotide sequences that predispose to formation of non-canonical DNA structure of G-quadruplexes, closely related with gene expression regulation and double strand DNA breaks, within vertebrata and yeast nuclear and mitochondrial genomes was carried out. Data on preferable localization of potential quadruplexes within non-coding sequences, their evolutionary conservation, and existing homology between them in mitochondrial and nuclear genomes were obtained. A possible interrelation between quadruplexes, Pif1 helicase and genomic instability is discussed.
authors.forename: B L
authors.initials: BL
authors.lastname: Zybaĭlov
authors.forename: M D
authors.initials: MD
authors.lastname: Sherpa
authors.forename: G V
authors.initials: GV
authors.lastname: Glazko
authors.forename: K D
authors.initials: KD
authors.lastname: Raney
authors.forename: V I
authors.initials: VI
authors.lastname: Glazko
mesh_terms: D002467:Cell Nucleus / Q000235:genetics; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D053903:DNA Breaks, Double-Stranded; D004265:DNA Helicases / Q000235:genetics; D054856:G-Quadruplexes; D005786:Gene Expression Regulation; D016678:Genome; D054629:Genome, Mitochondrial; D042822:Genomic Instability; D008928:Mitochondria / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D004247:DNA; D004265:DNA Helicases