title: Postasphyxial renal injury in newborns as a prognostic factor of neurological outcome.
abstract: OBJECTIVE
  To estimate if an acute postasphyxial renal injury in newborns could indicate a neurological outcome.
  
  
  METHODS
  We conducted a prospective clinical trial on 50 full-term newborns with 5-minute Apgar score <7 (asphyxiated group) and a control group of 50 full-term newborns with 5-min Apgar score ≥ 7 (non-asphyxiated group). Renal function was assessed on the third day of life by serum values of creatinine, cystatin C and β2-microglobulin (β2M) and glomerular filtration rate (GFR). All newborns had brain and renal ultrasonography at early stages and were followed by Amiel-Tison Neurological Assassment (ATNA) throughout the first year of life.
  
  
  RESULTS
  Mean GFR was significantly lower in asphyxiated than in non-asphyxiated group (22.08 ± 6.66 ml/min/1, 73 m(2) versus 35.42 ± 2.26 ml/min/1, 73 m(2); p < 0.001) and serum values of creatinine, cystatin C and β2M were significantly higher (1.13 versus 0.66 mg/dl; 3.92 versus 1.52 mg/l; 1.53 versus 0.99 mg/l; p < 0.001). In asphyxiated group ATNA results throughout the first year of life significantly correlated with renal function (p < 0.01). A correlation of ATNA with Apgar score at 5 min, Sarnat and Sarnat staging of hypoxic ischemic encephalopathy and brain and renal ultrasonography has also been significant (p < 0.01).
  
  
  CONCLUSIONS
  Our study showed a significant correlation between early impairment of renal function due to neonatal asphyxia with neurological outcome at the end of the first year of life.
authors.affiliation: Department of Neonatology, Pediatric Clinic, Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina .
authors.forename: Emina
authors.initials: E
authors.lastname: Hadzimuratovic
authors.forename: Snjezana
authors.initials: S
authors.lastname: Skrablin
authors.forename: Admir
authors.initials: A
authors.lastname: Hadzimuratovic
authors.forename: Senka Mesihovic
authors.initials: SM
authors.lastname: Dinarevic
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000150:complications*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000209:etiology; D007231:Infant, Newborn; D007677:Kidney Function Tests; D008297:Male; D009483:Neuropsychological Tests; D011379:Prognosis; D011446:Prospective Studies