title: The skeleton in the closet.
abstract: The origins of fibrodysplasia ossificans progressiva (FOP) in human history are unknown but the condition has been well described since Freke's account in 1740. Important contributions by physicians and scientists in the past two and a half centuries have converged on the remarkable skeleton of Harry Eastlack at The Mutter Museum of The College of Physicians in Philadelphia.
authors.affiliation: Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Frederick.Kaplan@uphs.upenn.edu
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Kaplan
mesh_terms: D052005:Bone Morphogenetic Protein Receptors, Type I / Q000235:genetics; D001842:Bone and Bones / Q000002:abnormalities*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009144:Museums; D020125:Mutation, Missense; D009221:Myositis Ossificans / Q000235:genetics / Q000266:history*; D015143:Philadelphia; D012863:Skeleton
chemical_list: D052005:Bone Morphogenetic Protein Receptors, Type I
keywords: ACVR1/ALK2; BMP; FOP; Fibrodysplasia ossificans progressiva; activin A receptor, type I/activin receptor-like kinase 2; bone morphogenetic protein; fibrodysplasia ossificans progressiva