title: Synthesis and antioxidant activities of acetamidomethylsulfonyl bis heterocycles-oxazolyl/thiazolyl/imidazolyl-1,3,4-oxadiazoles.
abstract: A new class of acetamidomethylsulfonyl bis heterocycles-oxazolyl-1,3,4-oxadiazoles, -thiazolyl-1,3,4-oxadiazoles, and -imidazolyl-1,3,4-oxadiazoles were synthesized from the synthetic intermediates, methyl 2-((4-aryloxazol-2-ylcarbamoyl)methylsulfonyl)acetate, methyl 2-((4-arylthiazol-2-ylcarbamoyl)methylsulfonyl)acetate, and methyl 2-((4-aryl-1H-imidazol-2-ylcarbamoyl)methylsulfonyl)acetate. All the title compounds were tested for their antioxidant activity. The oxadiazolylmethylsulfonyloxazolylacetamide displayed excellent radical-scavenging activity when compared with the standard ascorbic acid.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
authors.forename: Nabhubygari
authors.initials: N
authors.lastname: Mahaboob Basha
authors.forename: Gopala
authors.initials: G
authors.lastname: Lavanya
authors.forename: Adivireddy
authors.initials: A
authors.lastname: Padmaja
authors.forename: Venkatapuram
authors.initials: V
authors.lastname: Padmavathi
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000737:chemistry; D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D007093:Imidazoles; D010069:Oxadiazoles; D010851:Picrates; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D001205:Ascorbic Acid
keywords: 1,3,4-Oxadiazole; Antioxidant activity; Imidazole; Oxazole; Thiazole