title: Multiple roles of the gene zinc finger homeodomain-2 in the development of the Drosophila wing.
abstract: The gene zfh2 and its human homolog Atbf1 encode huge molecules with several homeo- and zinc finger domains. It has been reported that they play important roles in neural differentiation and promotion of apoptosis in several tissues of both humans and flies. In the Drosophila wing imaginal disc, Zfh2 is expressed in a dynamic pattern and previous results suggest that it is involved is proximal-distal patterning. In this report we go further in the analysis of the function of this gene in wing development, performing ectopic expression experiments and studying its effects in genes involved in wing development. Our results suggest that Zfh2 plays an important role controlling the expression of several wing genes and in the specification of those cellular properties that define the differences in cell proliferation between proximal and distal domains of the wing disc.
authors.affiliation: Centro de Biología Molecular-Severo Ochoa, Universidad Autónoma-Cantoblanco, 28049 Madrid, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Perea
authors.forename: Katie
authors.initials: K
authors.lastname: Molohon
authors.forename: Kevin
authors.initials: K
authors.lastname: Edwards
authors.forename: Fernando J
authors.initials: FJ
authors.lastname: Díaz-Benjumea
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D060227:Imaginal Discs / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014921:Wings, Animal / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; C490626:NAB protein, Drosophila; D012097:Repressor Proteins; C114494:dve protein, Drosophila; C077729:Zfh2 protein, Drosophila; D049452:Green Fluorescent Proteins
keywords: Drosophila; Pattern formation; Wing development; Zinc finger homeodomain-2