title: Quantification of the stapedial reflex reveals delayed responses in autism.
abstract: Autism is a developmental disorder characterized, in part, by sensory abnormalities. It is well established that most if not all patients with autism have problems with auditory processing, ranging from deafness to hyperacusis, and physiological testing of auditory function (i.e. auditory brain stem responses) implicates brain stem dysfunction in autism. Additionally, previous research from this lab has revealed significantly fewer auditory brain stem neurons in autistic subjects as young as 2 years of age. These observations have led us to hypothesize that objective, noninvasive measures of auditory function can be used as an early screening tool to identify neonates with an elevated risk of carrying a diagnosis of autism. Here, we provide a detailed quantitative investigation of the acoustic stapedial reflex (ASR), a three- or four-neuron brain stem circuit, in young autistic subjects and normal developing controls. Indeed, we find significantly lower thresholds, responses occurring at significantly longer latency and right-left asymmetry in autistic subjects. The results from this investigation support deficits in auditory function as a cardinal feature of autism and suggest that individuals with autism can be identified by their ASR responses.
authors.affiliation: Department of Neurology, University of Pittsburgh Medical Center-Hamot, Erie, Pennsylvania.
authors.forename: Richard
authors.initials: R
authors.lastname: Lukose
authors.forename: Kevin
authors.initials: K
authors.lastname: Brown
authors.forename: Carol M
authors.initials: CM
authors.lastname: Barber
authors.forename: Randy Joseph
authors.initials: RJ
authors.lastname: Kulesza
mesh_terms: D000293:Adolescent; D001288:Attention / Q000502:physiology; D001308:Auditory Perceptual Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D001309:Auditory Threshold / Q000502:physiology; D001933:Brain Stem / Q000503:physiopathology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis* / Q000503:physiopathology*; D003056:Cochlear Nerve / Q000503:physiopathology; D017626:Cochlear Nucleus / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values; D012021:Reflex, Abnormal / Q000502:physiology*; D012022:Reflex, Acoustic / Q000502:physiology*
keywords: auditory; autistic; facial nucleus; superior olive