title: Tigecycline induction of phenol-soluble modulins by invasive methicillin-resistant Staphylococcus aureus strains.
abstract: We examined the effects of tigecycline on three types of exoproteins, α-type phenol-soluble modulins (PSMα1 to PSMα4), α-hemolysin, and protein A, in 13 methicillin-resistant Staphylococcus aureus isolates compared to those of clindamycin and linezolid. Paradoxical increases in PSMαs occurred in 77% of the isolates with tigecycline at 1/4 and 1/8 MICs and clindamycin at 1/8 MIC compared to only 23% of the isolates with linezolid at 1/8 MIC. Induction was specific to PSMα1 to PSMα4, as protein A and α-hemolysin production was decreased under the same conditions by all of the antibiotics used.
authors.affiliation: University of Southern California, Los Angeles, California, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Yamaki
authors.forename: Timothy
authors.initials: T
authors.lastname: Synold
authors.forename: Annie
authors.initials: A
authors.lastname: Wong-Beringer
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000819:agonists* / Q000096:biosynthesis; D002981:Clindamycin / Q000494:pharmacology; D003470:Culture Media; D006801:Humans; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D023303:Oxazolidinones / Q000494:pharmacology; D020033:Protein Isoforms / Q000819:agonists / Q000096:biosynthesis; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D000078304:Tigecycline
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D003470:Culture Media; D023303:Oxazolidinones; D020033:Protein Isoforms; C025971:staphylococcal delta toxin; D002981:Clindamycin; D000078304:Tigecycline; D008911:Minocycline; D000069349:Linezolid