title: The expression and regulation of microRNA-125b in cancers.
abstract: Cancer is one of the leading causes of death worldwide. There is a definite need for novel approaches to improve the diagnostics and treatment of cancers. The pathological processes leading to carcinoma are associated with the altered expression of a specific gene relevant to malignancy. MicroRNA-125b (miR-125b) is a small non-coding, multipurpose miRNA that plays a key role in several different biological processes. Increasing amounts of evidence indicates that miR-125b may serve as a diagnostic biomarker of certain kinds of cancers. miR-125b may be suitable to be used as a therapeutical target in several human diseases including neoplastic disease. Here, we review the latest progress in the identification and validation of the relationship between cancer-related miR-125b and cancers, and discuss the functions of miR-125b that regulates many processes of diseases, including cell proliferation, differentiation, and apoptosis.
authors.affiliation: National & Regional United Engineering Laboratory of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.forename: Shiwu
authors.initials: S
authors.lastname: Dong
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Zhao
authors.initials: Z
authors.lastname: Xie
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D018390:Gene Targeting; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics*
chemical_list: C531888:MIRN125 microRNA, human; D035683:MicroRNAs
keywords: cancer; gene expression; miR-125b; target gene