title: Lipidomics of essential fatty acids and oxygenated metabolites.
abstract: Polyunsaturated fatty acids in mammals may be oxygenated into a myriad of bioactive products through di- and monooxygenases, products that are rapidly degraded to control their action. To evaluate the phenotypes of biological systems regarding this wide family of compounds, a lipidomics approach in function of time and compartments would be relevant. The current review takes into consideration most of the diverse oxygenated metabolites of essential fatty acids at large and their immediate degradation products. Their biological function and life span are considered. Overall, this is a fluxolipidomics approach that is emerging.
authors.affiliation: Université de Lyon, UMR 1060 Inserm, IMBL, INSA-Lyon, Villeurbanne, France. michel.lagarde@insa-lyon.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Lagarde
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bernoud-Hubac
authors.forename: Catherine
authors.initials: C
authors.lastname: Calzada
authors.forename: Evelyne
authors.initials: E
authors.lastname: Véricel
authors.forename: Michel
authors.initials: M
authors.lastname: Guichardant
mesh_terms: D016718:Arachidonic Acid / Q000378:metabolism; D001682:Biological Availability; D063388:Endocannabinoids / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D019787:Linoleic Acid / Q000378:metabolism; D015227:Lipid Peroxidation; D010100:Oxygen / Q000378:metabolism; D017962:alpha-Linolenic Acid / Q000378:metabolism
chemical_list: D063388:Endocannabinoids; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D017962:alpha-Linolenic Acid; D016718:Arachidonic Acid; D019787:Linoleic Acid; D010100:Oxygen
keywords: Fluxes; Leukotrienes; Metabolism; Peroxidation; Prostanoids