title: Antiproliferative triterpenoid saponins from the stem of Psychotria sp.
abstract: Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-MB-231, MCF-7, MCF-7/ADM, HepG2, and HepG2/ADM) are reported for the first time. Psychotrianoside C (3) showed the most potent antiproliferative activity among these saponins, and the IC50 value of 3 against MDA-MB-231 was 2.391 ± 0.161 µM. Compound 3 was also found to induce apoptosis.
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, PR China. zhangcuixian@yahoo.com.cn
authors.forename: Cui-Xian
authors.initials: CX
authors.lastname: Zhang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhang
authors.forename: Min-Feng
authors.initials: MF
authors.lastname: Chen
authors.forename: Shan-Yue
authors.initials: SY
authors.lastname: Guan
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Yao
authors.forename: Xi-Xin
authors.initials: XX
authors.lastname: He
authors.forename: Ling-Fang
authors.initials: LF
authors.lastname: Lei
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhong
authors.forename: Zhi-Fang
authors.initials: ZF
authors.lastname: Wang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D032069:Psychotria / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes