title: Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis.
abstract: BACKGROUND
  There is increasing evidence of the effect of maternal vitamin D intake during pregnancy on the risk of asthma and allergic outcomes in offspring. However, studies on the relationship between cord levels of 25-hydroxyvitamin D (25[OH]D) and asthma and allergic diseases are very few.
  
  
  OBJECTIVE
  Our aim was to investigate the associations between cord serum 25(OH)D levels and asthma, wheezing, allergic rhinitis, and atopic dermatitis in the offspring from birth to 5 years.
  
  
  METHODS
  Cord blood samples were collected at birth and analyzed for 25(OH)D levels in 239 newborns from the Etude des Déterminants pré et post natals du développement et de la santé de l'Enfant (EDEN) birth cohort. The children were followed up until age 5 years by using International Study of Asthma and Allergies in Childhood-based symptom questionnaires.
  
  
  RESULTS
  The median cord serum level of 25(OH)D was 17.8 ng/mL (interquartile range, 15.1 ng/mL). By using multivariable-adjusted logistic regression models, a significant inverse association was observed between cord serum 25(OH)D levels and risk of transient early wheezing and early- and late-onset atopic dermatitis, as well as atopic dermatitis, by the ages of 1, 2, 3, and 5 years. We found no association between cord serum 25(OH)D levels and asthma and allergic rhinitis at age 5 years.
  
  
  CONCLUSIONS
  Cord serum 25(OH)D levels were inversely associated with the risk of transient early wheezing and atopic dermatitis by the age of 5 years, but no association was found with asthma and allergic rhinitis.
authors.affiliation: INSERM (Institut national de la santé et de la recherche médicale), Epidemiology of Allergic and Respiratory Diseases (EPAR) Department, Paris, France; Medical School Saint-Antoine, UPMC Univ6, Paris, France. Electronic address: baiz@u707.jussieu.fr.
authors.forename: Nour
authors.initials: N
authors.lastname: Baïz
authors.affiliation: INSERM, Epidemiological Research in Perinatal Health and Women's and Child Health, UMR-S953, Villejuif, France; University Pierre and Marie Curie, UMR-S953, Paris, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Dargent-Molina
authors.affiliation: Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.
authors.forename: John D
authors.initials: JD
authors.lastname: Wark
authors.affiliation: Laboratoire de physiologie, Université Paris-Descartes, Hôpital Necker-Enfants-Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Souberbielle
authors.affiliation: INSERM (Institut national de la santé et de la recherche médicale), Epidemiology of Allergic and Respiratory Diseases (EPAR) Department, Paris, France; Medical School Saint-Antoine, UPMC Univ6, Paris, France.
authors.forename: Isabella
authors.initials: I
authors.lastname: Annesi-Maesano
mesh_terms: D000328:Adult; D002675:Child, Preschool; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000097:blood / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012135:Respiratory Sounds / Q000276:immunology*; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000097:blood / Q000453:epidemiology*; D012306:Risk; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; D007073:Immunoglobulin E; C104450:25-hydroxyvitamin D
keywords: 25(OH)D; 25-Hydroxyvitamin D; 25-hydroxyvitamin D; DC; Dendritic cell; EDEN; Etude des Déterminants pré et post natals du développement et de la santé de l′Enfant; OR; Odds ratio; Vitamin D; allergic diseases; atopic dermatitis; cord blood; mother-child cohort; wheezing