title: Hybridization chain reaction-based branched rolling circle amplification for chemiluminescence detection of DNA methylation.
abstract: A novel hybridization chain reaction-based branched rolling circle amplification combining the fabrication of multi-HRP-capped MNPs is developed for chemiluminescence detection of DNA methyltransferase activities and inhibitors with high sensitivity in a well-controlled manner.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Sai
authors.initials: S
authors.lastname: Bi
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhao
authors.forename: Baoyu
authors.initials: B
authors.lastname: Luo
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Zhu
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D019175:DNA Methylation / Q000187:drug effects; D015252:Deoxyribonucleases, Type II Site-Specific / Q000037:antagonists & inhibitors / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D008163:Luminescent Measurements; D058185:Magnetite Nanoparticles / Q000737:chemistry; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000964:Antimetabolites, Antineoplastic; D058185:Magnetite Nanoparticles; D004247:DNA; C058693:Dam methyltransferase; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific); C020102:endodeoxyribonuclease DpnI; D015252:Deoxyribonucleases, Type II Site-Specific; D005472:Fluorouracil