title: [Indirect comparison of different adjuvant chemotherapies for stage II-III gastric cancer after D2 gastrectomy in Asian patients].
abstract: OBJECTIVE
  To compare efficacy of different adjuvant chemotherapy regimens for stage II-III gastric cancer after D2 gastrectomy in Asian patients.
  
  
  METHODS
  Associated literatures were searched through electronic databases and hand-searching. Prospective randomized clinical trials (RCTs) comparing adjuvant chemotherapy after D2 gastrectomy with surgery alone were included in the study. Overall survival and disease-free survival were chosen as the endpoints. Relative hazard was analyzed by Bucher adjusted indirect comparison.
  
  
  RESULTS
  Two RCTs were selected, including comparison between S-1 versus surgery alone and comparison between XELOX versus surgery alone. There was no statistical difference in overall survival between the two regimens (HR=0.94, 95%CI:0.62-1.44, P=0.79). The recurrence risk of S-1 was slightly higher as compared to XELOX, but no statistical difference was found (HR=1.11, 95%CI:0.80-1.53, P=0.54).
  
  
  CONCLUSIONS
  The adjuvant chemotherapy with S-1 is similar to XELOX for stage II-III gastric cancer after D2 gastrectomy in Asian patients.
authors.affiliation: Department of Oncology, The Sun Yat-sen Memorial Hospital, Guangzhou 510120, China. xiederong@21cn.com.
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.forename: Yuan-dong
authors.initials: YD
authors.lastname: Zhang
authors.forename: Si-wei
authors.initials: SW
authors.lastname: Zhou
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.forename: De-rong
authors.initials: DR
authors.lastname: Xie
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D000069287:Capecitabine; D017024:Chemotherapy, Adjuvant; D003841:Deoxycytidine / Q000031:analogs & derivatives; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D010071:Oxaloacetates; D011182:Postoperative Care; D016032:Randomized Controlled Trials as Topic; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D010071:Oxaloacetates; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil