title: [Prophylactic effect of probiotic strains Bifidobacterium animalis VKL and VKB on stress-induced lesions in the gastric mucosa of rats].
abstract: It was investigated the effect of probiotic strains Bifidobacterium animalis VKL and VKB and their mixture on erosive and ulcerative lesions in the gastric mucosa (GM) of rats induced by water immersion restraint stress. It was found that separate prophylactic introduction for 14 days of Bifidobacterium animalis VKL or Bifidobacterium animalis VKB didn't protect the GM from erosive and ulcerative lesions induced by stress. Contrary prophylactic introduction of Bifidobacterium animalis VKL and VKB mixture has been effective in protecting the GM from the lesions. One of the mechanisms of the gastroprotection of these probiotic strains is prevention of mucus barrier from degradation, which was evident in decrease of free fucose and hexuronic acids content. These results confirm the expediency ofprobiotics use for the prevention of stress-induced lesions in the GM.
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Spivak
authors.forename: L M
authors.initials: LM
authors.lastname: Lazarenko
authors.forename: T M
authors.initials: TM
authors.lastname: Falalieieva
authors.forename: O V
authors.initials: OV
authors.lastname: Virchenko
authors.forename: K S
authors.initials: KS
authors.lastname: Neporada
mesh_terms: D000818:Animals; D001644:Bifidobacterium / Q000254:growth & development*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005260:Female; D005508:Food Deprivation; D005632:Fructose / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D006603:Hexuronic Acids / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control; D013315:Stress, Psychological / Q000473:pathology*
chemical_list: D006603:Hexuronic Acids; D005632:Fructose; D006909:Hydroxyproline