title: Nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan.
abstract: Neisseria gonorrhoeae is one of the most important pathogens causing sexually transmitted infection, and strains that are resistant to several antimicrobials are increasing. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the first nationwide surveillance. The urethral discharge was collected from male patients with urethritis at 51 medical facilities from April 2009 to October 2010. Of the 156 specimens, 83 N. gonorrhoeae strains were tested for susceptibility to 18 antimicrobial agents. The prevalence of β-lactamase-producing strains and chromosomally mediated resistant strains were 7.2 % and 16.5 %, respectively. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) of ceftriaxone for 7 strains (8.4 %) was 0.125 μg/ml. One strain was resistant to cefixime (MIC 0.5 μg/ml). The MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin, and tosufloxacin, showed a bimodal distribution. The MIC of sitafloxacin was lower than those of the three fluoroquinolones listed here, and it was found that the antimicrobial activity of sitafloxacin was stronger than that of the fluoroquinolones. The MIC of azithromycin in 2 strains was 2 μg/ml, but no high-level resistance to macrolides was detected.
authors.affiliation: Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan. hamaryo@med.uoeh-u.ac.jp
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Hamasuna
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Yasuda
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Uehara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hayami
authors.forename: Shingo
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Shinichi
authors.initials: S
authors.lastname: Minamitani
authors.forename: Akira
authors.initials: A
authors.lastname: Watanabe
authors.forename: Aikichi
authors.initials: A
authors.lastname: Iwamoto
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Totsuka
authors.forename: Junichi
authors.initials: J
authors.lastname: Kadota
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
authors.forename: Junko
authors.initials: J
authors.lastname: Sato
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hanaki
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyota
authors.forename: Shin
authors.initials: S
authors.lastname: Egawa
authors.forename: Kazushi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Soichi
authors.initials: S
authors.lastname: Arakawa
authors.forename: Masato
authors.initials: M
authors.lastname: Fujisawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kumon
authors.forename: Kanao
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Akio
authors.initials: A
authors.lastname: Matsubara
authors.forename: Seiji
authors.initials: S
authors.lastname: Naito
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tatsugami
authors.forename: Shin
authors.initials: S
authors.lastname: Ito
authors.forename: Harunori
authors.initials: H
authors.lastname: Narita
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Kanokogi
authors.forename: Toru
authors.initials: T
authors.lastname: Sumii
authors.forename: Kenji
authors.initials: K
authors.lastname: Ito
authors.forename: Takahide
authors.initials: T
authors.lastname: Hosobe
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kawai
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kawano
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takayama
authors.forename: Takamasa
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Endo
authors.forename: Takamine
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Maeda
authors.forename: Mutsumasa
authors.initials: M
authors.lastname: Yoh
authors.forename: Masanobu
authors.initials: M
authors.lastname: Horie
authors.forename: Masayasu
authors.initials: M
authors.lastname: Ito
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Chokyu
authors.forename: Hideari
authors.initials: H
authors.lastname: Ihara
authors.forename: Kikuo
authors.initials: K
authors.lastname: Akiyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Uno
authors.forename: Koichi
authors.initials: K
authors.lastname: Monden
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kaji
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nishimura
authors.forename: Motoshi
authors.initials: M
authors.lastname: Kawahara
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Konishi
authors.forename: Shohei
authors.initials: S
authors.lastname: Nishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishihara
authors.forename: Masaru
authors.initials: M
authors.lastname: Yoshioka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D015995:Prevalence; D062486:Public Health Surveillance; D014526:Urethritis / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents