title: Doxycycline-induced cutaneous inflammation with systemic symptoms in a patient with acne vulgaris.
abstract: BACKGROUND
  Doxycycline is a commonly prescribed antibiotic for the treatment of acne vulgaris. Often preferred to other tetracyclines due to a safer and milder side-effect profile, doxycycline is more frequently prescribed as a treatment of this common condition.
  
  
  OBJECTIVE
  To present a case report of a young patient who developed skin eruptions over the extremities; myalgias; fatigue; swelling involving the face, hands, and feet; headache; and mood changes after 2 years of using doxycycline. She promptly developed similar symptoms after a rechallenge with doxycycline 1 year later.
  
  
  CONCLUSIONS
  This important finding will make practitioners more vigilant to the side effects of this medication despite its current safety profile and regardless of the time that a patient is using it.
authors.affiliation: Hospital for Sick Children, Departments of Paediatrics and Pediatrics Laboratory Medicine, University of Calgary, Calgary. jdebosz@ucalgary.ca
authors.forename: Miriam
authors.initials: M
authors.lastname: Weinstein
authors.forename: Ronald
authors.initials: R
authors.lastname: Laxer
authors.forename: Joanna
authors.initials: J
authors.lastname: Debosz
authors.forename: Gino
authors.initials: G
authors.lastname: Somers
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004318:Doxycycline / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline