title: High-density polytetrafluoroethylene membranes in guided bone and tissue regeneration procedures: a literature review.
abstract: Expanded polytetrafluoroethylene (e-PTFE) has been used successfully as a membrane barrier for regeneration procedures. However, when exposed to the oral cavity, its high porosity increases the risk of early infection, which can affect surgical outcomes. An alternative to e-PTFE is non-expanded and dense polytetrafluoroethylene (n-PFTE), which results in lower levels of early infection following surgical procedures. The aim of this literature review was to analyze and describe the available literature on n-PFTE, report the indications for use, advantages, disadvantages, surgical protocols, and complications. The medical databases Medline-PubMed and Cochrane Library were searched and supplemented with a hand search for reports published between 1980 and May 2012 on n-PTFE membranes. The search strategy was limited to animal, human, and in vitro studies in dental journals published in English. Twenty-four articles that analyzed the use of n-PTFE as a barrier membrane for guided tissue regeneration and guided bone regeneration around teeth and implants were identified: two in vitro studies, seven experimental studies, and 15 clinical studies. There is limited clinical and histological evidence for the use of n-PTFE membranes at present, with some indications in guided tissue regeneration and guided bone regeneration in immediate implants and fresh extraction sockets.
authors.affiliation: Department of Periodontology, Universitat Internacional de Catalunya, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Carbonell
authors.affiliation: Department of Periodontology, Universitat Internacional de Catalunya, Spain.
authors.forename: I Sanz
authors.initials: IS
authors.lastname: Martín
authors.affiliation: Department of Periodontology, Universitat Internacional de Catalunya, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Santos
authors.affiliation: Department of Periodontology, Universitat Internacional de Catalunya, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Pujol
authors.affiliation: Department of Periodontology, Universitat Internacional de Catalunya, Spain.
authors.forename: J D
authors.initials: JD
authors.lastname: Sanz-Moliner
authors.affiliation: Department of Periodontology, Universitat Internacional de Catalunya, Spain. Electronic address: jose@nartperiodoncia.com.
authors.forename: J
authors.initials: J
authors.lastname: Nart
mesh_terms: D000818:Animals; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene
keywords: dense PTFE; high-density PTFE; microporous PTFE; nano-porous PTFE; non-expanded PTFE; non-permeable PTFE; non-porous PTFE