title: [Effect of wheat oligo-peptides on antioxidant function in aged mice].
abstract: OBJECTIVE
  To study the effect of wheat oligo-peptides on antioxidant function in vitro and in vivo.
  
  
  METHODS
  Male KM aged mice were randomly divided into 4 groups according to the serum MDA level, i. e. the negative control group, low-dose group, middle-dose group and high-dose group (0, 500, 1000, 2000 mg/kg BW of wheat oligo-peptides). After a 30-day administration of wheat oligo-peptides, the content of serum MDA, activity of SOD, GSH-Px and T-AOC were determined. The reducing power, DPPH radical and hydroxyl radical scavenging activity were also determined to evaluate the antioxidant activity in vitro.
  
  
  RESULTS
  The wheat oligo-peptides were found a good reducing power in vitro (R=0.97), scavenging activity of DPPH radical and hydroxyl radical (RDPPH.=0.90, R.OH=0.91). In vivo experiment, the activity of serum SOD and GSH-Px, and the serum T-AOC of all treated groups was significantly increased compared with negative control group (P<0.05).
  
  
  CONCLUSIONS
  The results from this study showed that wheat oligo-peptides have a good antioxidant activity both in vitro and in vivo.
authors.affiliation: West China School of Public Health, Sichuan University, Chengdu 610041, China. zengyu_1230@163.com
authors.forename: Yu
authors.initials: Y
authors.lastname: Zeng
authors.forename: Ya
authors.initials: Y
authors.lastname: Yuan
authors.forename: Xingchang
authors.initials: X
authors.lastname: Pan
authors.forename: Lishi
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000502:physiology*; D005979:Glutathione Peroxidase / Q000097:blood; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000097:blood; D014908:Triticum / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D009842:Oligopeptides; D010936:Plant Extracts; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase