title: A detailed evaluation of TomoDirect 3DCRT planning for whole-breast radiation therapy.
abstract: The goal of this work was to develop planning strategies for whole-breast radiotherapy (WBRT) using TomoDirect three-dimensional conformal radiation therapy (TD-3DCRT) and to compare TD-3DCRT with conventional 3DCRT and TD intensity-modulated radiation therapy (TD-IMRT) to evaluate differences in WBRT plan quality. Computed tomography (CT) images of 10 women were used to generate 150 WBRT plans, varying in target structures, field width (FW), pitch, and number of beams. Effects on target and external maximum doses (EMD), organ-at-risk (OAR) doses, and treatment time were assessed for each parameter to establish an optimal planning technique. Using this technique, TD-3DCRT plans were generated and compared with TD-IMRT and standard 3DCRT plans. FW 5.0cm with pitch = 0.250cm significantly decreased EMD without increasing lung V20Gy. Increasing number of beams from 2 to 6 and using an additional breast planning structure decreased EMD though increased lung V20Gy. Changes in pitch had minimal effect on plan metrics. TD-3DCRT plans were subsequently generated using FW 5.0cm, pitch = 0.250cm, and 2 beams, with additional beams or planning structures added to decrease EMD when necessary. TD-3DCRT and TD-IMRT significantly decreased target maximum dose compared to standard 3DCRT. FW 5.0cm with 2 to 6 beams or novel planning structures or both allow for TD-3DCRT WBRT plans with excellent target coverage and OAR doses. TD-3DCRT plans are comparable to plans generated using TD-IMRT and provide an alternative to conventional 3DCRT for WBRT.
authors.affiliation: Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO.
authors.forename: Emma C
authors.initials: EC
authors.lastname: Fields
authors.forename: Rachel
authors.initials: R
authors.lastname: Rabinovitch
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Ryan
authors.forename: Moyed
authors.initials: M
authors.lastname: Miften
authors.forename: David C
authors.initials: DC
authors.lastname: Westerly
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal
keywords: 3DCRT; TomoDirect; Whole-breast radiation therapy