title: Experimental model of atelectasis in newborn piglets.
abstract: BACKGROUND
  There are few studies using animal models in chest physical therapy. However, there are no models to assess these effects in newborns. This study aimed to develop a model of obstructive atelectasis induced by artificial mucus injection in the lungs of newborn piglets, for the study of neonatal physiotherapy.
  
  
  METHODS
  Thirteen newborn piglets received artificial mucus injection via the endotracheal tube. X-rays and blood gas analysis confirmed the atelectasis.
  
  
  RESULTS
  The model showed consistent results between oxygenation parameters and radiological findings. Ten (76.9%) of the 13 piglets responded to the intervention. This did not significantly differ from the expected percentage of 50% by the binomial test (95% CI 46.2-95%, P = .09).
  
  
  CONCLUSIONS
  Our model of atelectasis in newborn piglets is both feasible and appropriate to evaluate the impact of physical therapies on atelectasis in newborns.
authors.affiliation: Postgraduate Program in Medicine-Pediatrics and Child Health.
authors.forename: Talitha
authors.initials: T
authors.lastname: Comaru
authors.forename: Humberto Holmer
authors.initials: HH
authors.lastname: Fiori
authors.forename: Renato Machado
authors.initials: RM
authors.lastname: Fiori
authors.forename: Priscila
authors.initials: P
authors.lastname: Padoim
authors.forename: Jaqueline Basso
authors.initials: JB
authors.lastname: Stivanin
authors.forename: Vinicius Duval
authors.initials: VD
authors.lastname: da Silva
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D010100:Oxygen / Q000097:blood; D026741:Physical Therapy Modalities; D001261:Pulmonary Atelectasis / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D011859:Radiography; D013552:Swine
chemical_list: D010100:Oxygen
keywords: animal model; atelectasis; mechanical ventilation; mucus; newborn; physiotherapy; swine