title: Antiplasmodial and cytotoxic flavans and diarylpropanes from the stems of Combretum griffithii.
abstract: Four new flavans, griffinoids A-D (1-4), and two new diarylpropanes, griffithanes E and F (7 and 8), together with two known flavans (5 and 6), four known diarylpropanes, and β-sitosterol, were isolated from the EtOAc extract of the stems of Combretum griffithii. Compounds 3, 4, 5, and 9 exhibited weak antiplasmodial activity, with IC50 values of 15.74, 13.04, 9.66, and 14.45 μM, respectively. In addition, compounds 4, 5, and 8 also exhibited weak cytotoxicity toward one or more cancer cell lines including human epidermoid carcinoma, human breast cancer, and human small cell lung cancer cell lines.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Panawan
authors.initials: P
authors.lastname: Moosophon
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
authors.forename: Mongkol
authors.initials: M
authors.lastname: Buayairaksa
authors.forename: Jirawan
authors.initials: J
authors.lastname: Noichan
authors.forename: Kitisak
authors.initials: K
authors.lastname: Poopasit
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029765:Combretum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D012855:Sitosterols / Q000302:isolation & purification; D013785:Thailand
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D012855:Sitosterols; C025473:gamma-sitosterol