title: Hyaluronidase for treatment of intravenous extravasations: implementation of an evidence-based guideline in a pediatric population.
abstract: OBJECTIVE
  To describe the implementation and evaluation of an evidence-based guideline, Hyaluronidase for Treatment of IV Extravasations, in a pediatric population.
  
  
  CONCLUSIONS
  Evidence of hyaluronidase efficacy suggests that timely administration will decrease the severity of tissue damage caused by extravasations, and result in cost savings. Implementation of this guideline increased user knowledge, incident reporting, and initiation of treatment, and decreased the average time to treatment administration.
  
  
  CONCLUSIONS
  Implementation strategies facilitate integration and sustained use of evidence-based treatments in clinical practice. Processes that promote evidence-based treatment are expected to improve outcomes and are therefore an important component of evaluation.
authors.affiliation: University of Iowa College of Nursing, University of Iowa Children's Hospital, Iowa City, Iowa, USA. kirsten-hanrahan@uiowa.edu
authors.forename: Kirsten
authors.initials: K
authors.lastname: Hanrahan
mesh_terms: D002648:Child; D019317:Evidence-Based Medicine; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy*; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D006821:Hyaluronoglucosaminidase
keywords: Evidence-based; extravasation; infiltration; intravenous therapy; pediatric