title: Pediatric cardiopulmonary bypass: does perfusion mode matter?
abstract: This current review describes how components of the cardiopulmonary bypass (CPB) circuit are selected and examines the benefits of pulsatile perfusion for use during CPB. Pulsatile flow generates significantly greater surplus hemodynamic energy (SHE) than nonpulsatile flow; higher SHE values have been associated with better microcirculation perfusion, lower rates of systemic inflammatory response, and better vital organ protection. Pulsatile perfusion may have a positive effect on clinical outcomes, play a role in preserving homeostasis, and help to decrease morbidity associated with CPB.
authors.affiliation: Penn State Hershey Pediatric Cardiovascular Research Center and Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Penn State Children's Hospital, Hershey, PA, USA.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Talor
authors.forename: Akif
authors.initials: A
authors.lastname: Undar
keywords: cardiopulmonary bypass (CPB); neonate; pediatric; perfusion