title: Effects of deformation on transmural dispersion of repolarization using in silico models of human left ventricular wedge.
abstract: Mechanical deformation affects the electrical activity of the heart through multiple feedback loops. The purpose of this work is to study the effect of deformation on transmural dispersion of repolarization and on surface electrograms using an in silico human ventricular wedge. To achieve this purpose, we developed a strongly coupled electromechanical cell model by coupling a human left ventricle electrophysiology model and an active contraction model reparameterized for human cells. This model was then embedded in tissue simulations on the basis of bidomain equations and nonlinear solid mechanics. The coupled model was used to evaluate effects of mechanical deformation on important features of repolarization and electrograms. Our results indicate an increase in the T-wave amplitude of the surface electrograms in simulations that account for the effects of cardiac deformation. This increased T-wave amplitude can be explained by changes to the coupling between neighboring myocytes, also known as electrotonic effect. The thickening of the ventricular wall during repolarization contributes to the decoupling of cells in the transmural direction, enhancing action potential heterogeneity and increasing both transmural repolarization dispersion and T-wave amplitude of surface electrograms. The simulations suggest that a considerable percentage of the T-wave amplitude (15%) may be related to cardiac deformation.
authors.affiliation: Simula Research Laboratory, Lysaker, Norway; Graduate Program in Computational Modeling of the Federal University of Juiz de Fora, Brazil.
authors.forename: B L
authors.initials: BL
authors.lastname: de Oliveira
authors.forename: B M
authors.initials: BM
authors.lastname: Rocha
authors.forename: L P S
authors.initials: LP
authors.lastname: Barra
authors.forename: E M
authors.initials: EM
authors.lastname: Toledo
authors.forename: J
authors.initials: J
authors.lastname: Sundnes
authors.forename: R
authors.initials: R
authors.lastname: Weber dos Santos
mesh_terms: D000200:Action Potentials; D003198:Computer Simulation; D004562:Electrocardiography; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D016276:Ventricular Function / Q000502:physiology*
keywords: T-wave; human electromechanical model; left ventricular wedge; mechanoelectrical feedback; transmural dispersion of repolarization