title: Photoacoustic needle: minimally invasive guidance to biopsy.
abstract: We introduce a needle probe based on photoacoustics (PA) to extend the scope of optical needle methods in guiding biopsies. Pulsed light is coupled to an optical fiber in a needle to be inserted in tissue, and PA signals are detected using an ultrasound imager used for needle guidance. This PA needle samples large volumes and possesses an imaging component so that sites forward and off-axis of the fiber are surveyed. This allows navigation of those regions for optical characterization and direct biopsy in a subsequent step. The concept is explored on simple phantoms and biological specimens.
authors.affiliation: Biomedical Photonic Imaging Group, MIRA Institute, University of Twente, P.O. Box 217, 7500AE Enschede, The Netherland. d.piras@utwente.nl
authors.forename: Daniele
authors.initials: D
authors.lastname: Piras
authors.forename: Chiel
authors.initials: C
authors.lastname: Grijsen
authors.forename: Peter
authors.initials: P
authors.lastname: Schütte
authors.forename: Wiendelt
authors.initials: W
authors.lastname: Steenbergen
authors.forename: Srirang
authors.initials: S
authors.lastname: Manohar
mesh_terms: D000818:Animals; D002645:Chickens; D005399:Fishes; D061705:Image-Guided Biopsy / Q000295:instrumentation* / Q000379:methods*; D019060:Minimally Invasive Surgical Procedures / Q000295:instrumentation* / Q000379:methods*; D008954:Models, Biological; D009132:Muscles / Q000000981:diagnostic imaging; D009339:Needles; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000295:instrumentation* / Q000379:methods*; D014463:Ultrasonography