title: Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study.
abstract: We examined the association between serum lipoprotein subclasses and the three measures of arterial stiffness, that is, (i) carotid-femoral pulse wave velocity (cfPWV), which is a gold standard measure of central arterial stiffness, (ii) brachial-ankle PWV (baPWV), which is emerging as a combined measure of central and peripheral arterial stiffness and (iii) femoral-ankle PWV (faPWV), which is a measure of peripheral arterial stiffness. Among a population-based sample of 701 apparently healthy Caucasian, Japanese American and Korean men aged 40-49 years, concentrations of lipoprotein particles were assessed by nuclear magnetic resonance (NMR) spectroscopy, and the PWV was assessed with an automated waveform analyzer (VP2000, Omron, Japan). Multiple linear regressions were performed to analyse the association between each NMR lipoprotein subclasses and PWV measures, after adjusting for cardiovascular risk factors and other confounders. A cutoff of P<0.01 was used for determining significance. All PWV measures had significant correlations with total and small low-density lipoprotein particle number (LDL-P) (all P<0.0001) but not LDL cholesterol (LDL-C) (all P>0.1), independent of race and age. In multivariate regression analysis, no NMR lipoprotein subclass was significantly associated with cfPWV (all P>0.01). However, most NMR lipoprotein subclasses had significant associations with both baPWV and faPWV (P<0.01). In this study of healthy middle-aged men, as compared with cfPWV, both baPWV and faPWV had stronger associations with particle numbers of lipoprotein subclasses. Our results may suggest that both baPWV and faPWV are related to arterial stiffness and atherosclerosis, whereas cfPWV may represent arterial stiffness alone.
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: A
authors.identifier: 0000000335734090
authors.initials: A
authors.lastname: Vishnu
authors.affiliation: College of Nursing, Korea University, Seoul, Republic of Korea.
authors.forename: J
authors.initials: J
authors.lastname: Choo
authors.affiliation: Department of Geriatric Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: K H
authors.initials: KH
authors.lastname: Masaki
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Mackey
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: E
authors.initials: E
authors.lastname: Barinas-Mitchell
authors.affiliation: Division of Pulmonary Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: C
authors.initials: C
authors.lastname: Shin
authors.affiliation: Department of Geriatric Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Willcox
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: A
authors.initials: A
authors.lastname: El-Saed
authors.affiliation: Non invasive Cardiology Laboratory, Queen's Medical Center, Honolulu, HI, USA.
authors.forename: T B
authors.initials: TB
authors.lastname: Seto
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Fujiyoshi
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miura
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Sutton-Tyrrell
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Kuller
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
authors.forename: H
authors.identifier: 0000000277424253
authors.initials: H
authors.lastname: Ueshima
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Sekikawa
mesh_terms: D000328:Adult; D055109:Ankle Brachial Index; D001213:Asian; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016014:Linear Models; D008074:Lipoproteins / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010414:Pennsylvania / Q000453:epidemiology; D058729:Peripheral Arterial Disease / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D056910:Republic of Korea / Q000453:epidemiology; D059289:Vascular Stiffness; D044465:White People
chemical_list: D015415:Biomarkers; D008074:Lipoproteins