title: [Application of biomarker CTX- II in osteoarthritis].
abstract: Effective biomarkers for clinical usage of osteoarthritis are still limited. It was confirmed that C-terminal crosslinking telopeptide of type I collagen (CTX- II) was a specific marker reflecting degradation of articular cartilage. Detection of CTX- II could promptly reflect level of cartilage injury and degradation ,diagnose OA,predict its progress,monitor effects of drug treatment, thus, reflect the condition of osteoarthritis patient indirectly. Application of CTX- II focused mainly on in the early stage of OA and need together to detect with other biomarkers,in order to more accurately reflection of the pathological changes of OA,but the specific clinical significance of CTX- II results still need to improve further.
authors.affiliation: Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Xue-Zong
authors.initials: XZ
authors.lastname: Wang
authors.forename: Ning-Yang
authors.initials: NY
authors.lastname: Gao
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Shen
authors.forename: Song-Pu
authors.initials: SP
authors.lastname: Wei
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Zheng
authors.forename: Yue-Long
authors.initials: YL
authors.lastname: Cao
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Zhan
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D002358:Cartilage, Articular / Q000473:pathology; D024043:Collagen Type II / Q000032:analysis*; D042241:Early Diagnosis; D006801:Humans; D010003:Osteoarthritis / Q000175:diagnosis*; D010446:Peptide Fragments / Q000032:analysis*
chemical_list: D015415:Biomarkers; D024043:Collagen Type II; D010446:Peptide Fragments; C543437:collagen II C-telopeptide