title: [Kidney function and liver transplantation].
abstract: BACKGROUND
  In liver cirrhosis renal function decreases as well. Hepatorenal syndrome is the most frequent cause of the decrease, but primary kidney failure, diabetes mellitus and some diseases underlying endstage liver failure (such as hepatitis C virus infection) can also play an important role. In liver transplantation several further factors (total cross-clamping of vena cava inferior, polytransfusion, immunosuppression) impair the renal function, too.
  
  
  OBJECTIVE
  The aim of this study was to analyse the changes in kidney function during the first postoperative year after liver transplantation.
  
  
  METHODS
  Retrospective data analysis was performed after primary liver transplantations (n = 319).
  
  
  RESULTS
  impaired preoperative renal function increased the devepolment of postoperative complications and the first year cumulative patient survival was significantly worse (91,7% vs 69,9%; p<0,001) in this group. If renal function of the patients increased above 60 ml/min/1,73 m2 after the first year, patient survival was better. Independently of the preoperative kidney function, 76% of the patients had impaired kidney function at the first postoperative year. In this group, de novo diabetes mellitus was more frequently diagnosed (22,5% vs 9,5%; p = 0,023).
  
  
  CONCLUSIONS
  Selection of personalized immunosuppressive medication has a positive effect on renal function.
authors.affiliation: Transzplantációs és Sebészeti Klinika, Budapest. gaman.gyorgy@med.semmelweis-univ.hu
authors.forename: György
authors.initials: G
authors.lastname: Gámán
authors.forename: Fanni
authors.initials: F
authors.lastname: Gelley
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Gerlei
authors.forename: Eszter
authors.initials: E
authors.lastname: Dabasi
authors.forename: Dénes
authors.initials: D
authors.lastname: Görög
authors.forename: Imre
authors.initials: I
authors.lastname: Fehérvári
authors.forename: László
authors.initials: L
authors.lastname: Kóbori
authors.forename: Gabriella
authors.initials: G
authors.lastname: Lengyel
authors.forename: Gergely
authors.initials: G
authors.lastname: Zádori
authors.forename: János
authors.initials: J
authors.lastname: Fazakas
authors.forename: Attila
authors.initials: A
authors.lastname: Doros
authors.forename: Enikő
authors.initials: E
authors.lastname: Sárváry
authors.forename: Balázs
authors.initials: B
authors.lastname: Nemes
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D003250:Constriction; D003920:Diabetes Mellitus / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006530:Hepatorenal Syndrome / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D057285:Precision Medicine; D057234:Preoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014682:Vena Cava, Inferior
chemical_list: D007166:Immunosuppressive Agents