title: Putting the brakes on anticancer therapies: suppression of innate immune pathways by tumor-associated myeloid cells.
abstract: Accumulating evidence has revealed that immunogenic cell death triggered by particular chemotherapeutic agents plays a critical role in harnessing antitumor immunity to clinical responses. However, negative regulatory pathways exist which suppress the induction of effective immune responses by a broad spectrum of anticancer therapies including 'non-immunogenic' regimens. Tumor-associated myeloid cells are unique in that they are capable of manipulating responses to anticancer drugs by utilizing negative regulatory factors of innate immune pathways, including damage-associated molecule-mediated pattern recognition and tolerogenic phagocytosis. Further elucidation of the molecular mechanisms regulating innate immune responses of tumor-associated myeloid cells under cellular stress should enhance the development of new molecular targeting therapies for patients with treatment-refractory cancers.
authors.affiliation: Research Center for Infection-associated Cancer, Institute for Genetic Medicine, Hokkaido University, Sapporo, 060-0815, Japan. Electronic address: jinushi@igm.hokudai.ac.jp.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Jinushi
authors.forename: Hideo
authors.initials: H
authors.lastname: Yagita
authors.forename: Hironori
authors.initials: H
authors.lastname: Yoshiyama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tahara
mesh_terms: D000970:Antineoplastic Agents / Q000276:immunology / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects / Q000276:immunology; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D058990:Molecular Targeted Therapy; D022423:Myeloid Cells / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents
keywords: chemoresistant niche; danger-associated molecular patterns; immunogenic cell death; innate immune pathways; phagocytosis receptors; tumor-associated myeloid cells