title: Predicting protein contact map using evolutionary and physical constraints by integer programming.
abstract: BACKGROUND
  Protein contact map describes the pairwise spatial and functional relationship of residues in a protein and contains key information for protein 3D structure prediction. Although studied extensively, it remains challenging to predict contact map using only sequence information. Most existing methods predict the contact map matrix element-by-element, ignoring correlation among contacts and physical feasibility of the whole-contact map. A couple of recent methods predict contact map by using mutual information, taking into consideration contact correlation and enforcing a sparsity restraint, but these methods demand for a very large number of sequence homologs for the protein under consideration and the resultant contact map may be still physically infeasible.
  
  
  RESULTS
  This article presents a novel method PhyCMAP for contact map prediction, integrating both evolutionary and physical restraints by machine learning and integer linear programming. The evolutionary restraints are much more informative than mutual information, and the physical restraints specify more concrete relationship among contacts than the sparsity restraint. As such, our method greatly reduces the solution space of the contact map matrix and, thus, significantly improves prediction accuracy. Experimental results confirm that PhyCMAP outperforms currently popular methods no matter how many sequence homologs are available for the protein under consideration.
  
  
  BACKGROUND
  http://raptorx.uchicago.edu.
authors.affiliation: Toyota Technological Institute at Chicago, 6045 S Kenwood, IL 60637, USA.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
authors.forename: Jinbo
authors.initials: J
authors.lastname: Xu
mesh_terms: D001185:Artificial Intelligence; D019143:Evolution, Molecular; D011382:Programming, Linear; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
chemical_list: D011506:Proteins