title: Nepheliosyne B, a new polyacetylenic acid from the new caledonian marine sponge Niphates sp.
abstract: A new C47 polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.
authors.affiliation: Chemistry Institute of Nice (ICN), UMR 7272 CNRS, Bioactive Molecules, University of Nice-Sophia Antipolis, ParcValrose, F-06108 Nice Cedex 02, France. nathalie.legrave@unice.fr
authors.forename: Nathalie
authors.initials: N
authors.lastname: Legrave
authors.forename: Souhir
authors.initials: S
authors.lastname: Hamrouni-Buonomo
authors.forename: Maeva
authors.initials: M
authors.lastname: Dufies
authors.forename: Vincent
authors.initials: V
authors.lastname: Guérineau
authors.forename: Jean
authors.initials: J
authors.lastname: Vacelet
authors.forename: Patrick
authors.initials: P
authors.lastname: Auberger
authors.forename: Philippe
authors.initials: P
authors.lastname: Amade
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mehiri
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001685:Biological Factors / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D053279:Polyynes / Q000737:chemistry* / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001685:Biological Factors; D005231:Fatty Acids, Unsaturated; C091092:nepheliosyne A; D053279:Polyynes