title: [Caspase-3 expression in the tissues of experimental melanoma and its metastases during matrix metalloproteinase-9 inhibition].
abstract: The specific features of caspase-3 expression were studied in intact tissues and skin melanoma cells, by reducing the activity of matrix metalloproteinase-9 in vivo. Immunohistochemical examination revealed no significant changes in the expression of caspase-3 in the primary tumor cells. There were the greatest changes in the organs having metastastic melanomas (lung, liver, spleen) and significant differences between control and treatment groups (p<0.05), unlike cardiac and nephritic tissues where the similar distinctions were absent.
mesh_terms: D000818:Animals; D053148:Caspase 3 / Q000096:biosynthesis*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D020780:Matrix Metalloproteinase 9; D008546:Melanoma, Experimental / Q000201:enzymology* / Q000473:pathology; D051379:Mice; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000201:enzymology* / Q000473:pathology
chemical_list: D009363:Neoplasm Proteins; D011480:Protease Inhibitors; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020780:Matrix Metalloproteinase 9; C501830:Mmp9 protein, mouse