title: Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer.
abstract: BACKGROUND
  Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.
  
  
  METHODS
  We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.
  
  
  RESULTS
  PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.
  
  
  CONCLUSIONS
  PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.
authors.affiliation: Department of Surgery, Kyushu University Beppu Hospital, Tsurumihara 4546, Beppu, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: G
authors.initials: G
authors.lastname: Sawada
authors.forename: J
authors.initials: J
authors.lastname: Kurashige
authors.forename: R
authors.initials: R
authors.lastname: Uchi
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: H
authors.initials: H
authors.lastname: Ueo
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: S
authors.initials: S
authors.lastname: Akiyoshi
authors.forename: H
authors.initials: H
authors.lastname: Eguchi
authors.forename: T
authors.initials: T
authors.lastname: Sudo
authors.forename: K
authors.initials: K
authors.lastname: Sugimachi
authors.forename: Y
authors.initials: Y
authors.lastname: Doki
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Mimori
mesh_terms: D002277:Carcinoma / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D002448:Cell Adhesion / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D015201:Meta-Analysis as Topic; D009362:Neoplasm Metastasis; D011379:Prognosis; D016019:Survival Analysis; D014162:Transfection; D015854:Up-Regulation / Q000235:genetics
chemical_list: D018398:Homeodomain Proteins; C082157:PRRX1 protein, human