title: Association of ABO blood group and risk of lung cancer in a multicenter study in Turkey.
abstract: BACKGROUND
  The ABO blood groups and Rh factor may affect the risk of lung cancer.
  
  
  METHODS
  We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them.
  
  
  RESULTS
  The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology.
  
  
  CONCLUSIONS
  In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.
authors.affiliation: Department of Medical Oncology, Ankara University School of Medicine, Turkey. yukselurun@gmail.com
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Urun
authors.forename: Gungor
authors.initials: G
authors.lastname: Utkan
authors.forename: Ayten Kayi
authors.initials: AK
authors.lastname: Cangir
authors.forename: Omur Berna
authors.initials: OB
authors.lastname: Oksuzoglu
authors.forename: Nuriye
authors.initials: N
authors.lastname: Ozdemir
authors.forename: Derya Gokmen
authors.initials: DG
authors.lastname: Oztuna
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kocaman
authors.forename: Hasan Şenol
authors.initials: HŞ
authors.lastname: Coşkun
authors.forename: Muhammet Ali
authors.initials: MA
authors.lastname: Kaplan
authors.forename: Cabir
authors.initials: C
authors.lastname: Yuksel
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirkazik
authors.forename: Fikri
authors.initials: F
authors.lastname: Icli
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012204:Rh-Hr Blood-Group System / Q000097:blood*; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System