title: A comprehensive study indicates PRSS1 gene is significantly associated with pancreatitis.
abstract: This comprehensive meta-analysis was applied to case-control studies of the association between pancreatitis and PRSS1 gene to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. PubMed, EMBASE, and Cochrane Library were searched in order to identify longitudinal studies evaluating pancreatitis disease and PRSS1 gene. Odds ratios (ORs) were pooled using a random-effects model. For the case-control studies, the authors found 1) support for the association between total pancreatitis and PRSS1 gene, both totally analyzed and subdivided analyzed {total: [OR:10.799, 95%CI:(5.489-21.242), p<0.000]; Europe: [OR:9.795, 95%CI:(2.923-32.819), p<0.000]; Asia: [OR:11.994, 95%CI:(5.156-27.898), p<0.000]}. 2) no evidence showed that this association was accounted for by any one study, and 3) no evidence showed any publication bias exist. In conclusion, PRSS1 gene was significantly associated with total pancreatitis disease, both totally and separately.
authors.affiliation: Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Orthopaedics and Traumatology, Department of Orthopaedics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Hong-xin
authors.initials: HX
authors.lastname: Zhang
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D010195:Pancreatitis / Q000235:genetics*; D014357:Trypsin / Q000235:genetics*
chemical_list: C489303:PRSS1 protein, human; D014357:Trypsin
keywords: PRSS1; meta-analysis; pancreatitis