title: No association between mitochondrial tRNA(Val) T1658C mutation and chronic progressive external ophthalmoplegia (CPEO).
abstract: Mutations in mitochondrial tRNA genes are one of the most important causes of mitochondrial diseases. Recently, a novel mt-tRNA(Val) T1658C mutation has been reported to be associated with chronic progressive external ophthalmoplegia (CPEO). To test this association, we performed a phylogenetic analysis of T1658C mutation, moreover, we used the bioinformatic tool to predict the thermodynamic change of tRNA(Val) with and without this mutation. Surprisingly, T1658C mutation was not evolutionary conserved and had little effect on tRNA(Val) folding. These data indicated that T1658C mutation should still be categorized as a polymorphism.
authors.affiliation: First affiliated Hospital of Henan University of Science and Technology , Luoyang , People's Republic of China and.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhou
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Wei
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D019295:Computational Biology / Q000379:methods*; D056726:Genetic Association Studies; D006801:Humans; D009690:Nucleic Acid Conformation; D017246:Ophthalmoplegia, Chronic Progressive External / Q000235:genetics*; D010802:Phylogeny; D017354:Point Mutation; D012313:RNA / Q000235:genetics*; D000077278:RNA, Mitochondrial; D012366:RNA, Transfer, Val / Q000235:genetics*; D013816:Thermodynamics
chemical_list: D000077278:RNA, Mitochondrial; D012366:RNA, Transfer, Val; D012313:RNA
keywords: Mitochondrial tRNA; mutation; pathogenic