title: Systems biological approaches to measure and understand vaccine immunity in humans.
abstract: Recent studies have demonstrated the utility of using systems approaches to identify molecular signatures that can be used to predict vaccine immunity in humans. Such approaches are now being used extensively in vaccinology, and are beginning to yield novel insights about the molecular networks driving vaccine immunity. In this review, we present a broad review of the methodologies involved in these studies, and discuss the promise and challenges involved in this emerging field of "systems vaccinology."
authors.affiliation: Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
authors.forename: Shuzhao
authors.initials: S
authors.lastname: Li
authors.forename: Helder I
authors.initials: HI
authors.lastname: Nakaya
authors.forename: Dmitri A
authors.initials: DA
authors.lastname: Kazmin
authors.forename: Jason Z
authors.initials: JZ
authors.lastname: Oh
authors.forename: Bali
authors.initials: B
authors.lastname: Pulendran
mesh_terms: D006801:Humans; D007109:Immunity; D049490:Systems Biology / Q000379:methods / Q000639:trends*; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines
keywords: Systems biology; Systems vaccinology; Vaccines