title: [The study on the relationship between serum folic acid and vitamin B2 levels and esophageal cancer].
abstract: OBJECTIVE
  To study the relationship between serum folic acid and VB2 levels and esophageal cancer.
  
  
  METHODS
  The enzyme-linked immunosorbent assay was used to observe the serum folic acid and vitamin B2 levels of the 1:1:1 paired of 106 groups, which include 106 cases of esophageal cancer, 106 cases of esophageal precancerous lesions and 106 cases of normal control group.
  
  
  RESULTS
  The levels of folic acid and VB2 in serum of esophageal cancer group and esophageal precancerous lesions group were significantly lower than normal control group (P<0.05), the level of folic acid in serum of esophageal cancer group was significantly lower than esophageal precancerous lesions group (P<0.05), but the difference of the serum VB2 of esophageal cancer group and esophageal precancerous lesions group was not statistically significant (P>0.05).
  
  
  CONCLUSIONS
  The folic acid and vitamin B2 deficiency has the relationship with the esophageal cancer occurrence and development.
authors.affiliation: School of Public Health, Environmental Medicine, Engineering, Key Laboratory of Ministry of Education, Southeast University, Nanjing 210009, China.
authors.forename: Liuli
authors.initials: L
authors.lastname: Bao
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.forename: Guiling
authors.initials: G
authors.lastname: Huang
authors.forename: Shaokang
authors.initials: S
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.forename: Tingting
authors.initials: T
authors.lastname: Wang
authors.forename: Fukang
authors.initials: F
authors.lastname: Liu
authors.forename: Guiju
authors.initials: G
authors.lastname: Sun
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D004938:Esophageal Neoplasms / Q000097:blood* / Q000453:epidemiology; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000097:blood* / Q000453:epidemiology; D012256:Riboflavin / Q000097:blood*
chemical_list: D005492:Folic Acid; D012256:Riboflavin