title: Signaling pathway switch in breast cancer.
abstract: Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells.
authors.affiliation: Centre de Recherche en Cancérologie de Marseille, Oncologie Moléculaire, "Equipe labellisée Ligue Contre le Cancer", UMR1068 Inserm, CNRS UMR7258, Institut Paoli-Calmettes, Aix-Marseille Université, 27 bd, Leï Roure, BP 30059, Marseille 13273, France. daniel.birnbaum@inserm.fr.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Guille
authors.forename: Max
authors.initials: M
authors.lastname: Chaffanet
authors.forename: Daniel
authors.initials: D
authors.lastname: Birnbaum