title: Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents.
abstract: Since the bacterial resistance to antibiotics is increasing rapidly, numerous studies have contributed to the design and synthesis of potent synthetic mimics of antimicrobial peptides (AMPs). In an attempt to find the pharmacophore of short antimicrobial peptidomimetics through systematic tuning of hydrophobic and hydrophilic patterns, we have identified a set of short histidine-derived antimicrobial peptides (SAMPs) with potent and broad-spectrum activity. A combination of high antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), without hemolytic activity and proteolytic stability makes these molecules promising candidates for novel antimicrobial therapeutics.
authors.affiliation: Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk 363-883, Republic of Korea.
authors.forename: Ravichandran N
authors.initials: RN
authors.lastname: Murugan
authors.forename: Binu
authors.initials: B
authors.lastname: Jacob
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Mija
authors.initials: M
authors.lastname: Ahn
authors.forename: Hoik
authors.initials: H
authors.lastname: Sohn
authors.forename: Ji-Hyung
authors.initials: JH
authors.lastname: Seo
authors.forename: Chaejoon
authors.initials: C
authors.lastname: Cheong
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: Hyun
authors.forename: Kyung S
authors.initials: KS
authors.lastname: Lee
authors.forename: Song Yub
authors.initials: SY
authors.lastname: Shin
authors.forename: Jeong Kyu
authors.initials: JK
authors.lastname: Bang
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006461:Hemolysis; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D057786:Peptidomimetics; D055550:Protein Stability
chemical_list: D000890:Anti-Infective Agents; D057786:Peptidomimetics
keywords: Methicillin-resistance Staphylococcus aureus; Proteolytic stability; Short antimicrobial peptidomimetics