title: Organically Modified Silica Nanoparticles with Intraparticle Heavy-Atom Effect on the Encapsulated Photosensitizer for Enhanced Efficacy of Photodynamic Therapy.
abstract: We report a novel nanoassembly formulation for photodynamic therapy, which is composed of covalently iodine-concentrated organically modified silica (ORMOSIL) nanoparticles (diameter <30 nm) and a hydrophobic photosensitizer embedded therein. Comparative studies with iodinated and non-iodinated nanoparticles have demonstrated that the intraparticle external heavy-atom effect on the encapsulated photosensitizer molecules significantly enhances the efficiency of1O2generation, and thereby, the in vitro PDT efficacy.
authors.affiliation: The Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, USA ; Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea.
authors.forename: Sehoon
authors.initials: S
authors.lastname: Kim
authors.forename: Tymish Y
authors.initials: TY
authors.lastname: Ohulchanskyy
authors.forename: Dhruba
authors.initials: D
authors.lastname: Bharali
authors.forename: Yihui
authors.initials: Y
authors.lastname: Chen
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Pandey
authors.forename: Paras N
authors.initials: PN
authors.lastname: Prasad