title: Metastatic prostate cancer proven by 18F-FCH PET/CT staging scan in patient with normal PSA but high PSA doubling time.
abstract: A 59-year-old man presented with frequent urination. Six months ago, his prostate-specific antigen (PSA) was 1.56 ng/mL; currently it is 3.5 ng/mL (PSA doubling time = 6 months; PSA velocity = 0.19 ng/mL/mo). Biopsy revealed aggressive prostate cancer (Gleason score 5 + 5). Staging with (18)F-fluorocholine PET/CT ((18)F-FCH PET/CT) demonstrated lymph node metastasis. After 6 months of hormonal therapy with goserelin, PSA decreased to 0.38 ng/mL. A (18)F-FCH PET/CT restaging scan demonstrated a global reduction of (18)F-FCH lesion uptake with disappearance of some mediastinal and iliac pelvic lymph node activity.
authors.affiliation: Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Marina
authors.initials: M
authors.lastname: Hodolič
authors.forename: Anna Margherita
authors.initials: AM
authors.lastname: Maffione
authors.forename: Jure
authors.initials: J
authors.lastname: Fettich
authors.forename: Borut
authors.initials: B
authors.lastname: Gubina
authors.forename: Marino
authors.initials: M
authors.lastname: Cimitan
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
mesh_terms: D002794:Choline / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D017430:Prostate-Specific Antigen / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; C514960:fluorocholine; D017430:Prostate-Specific Antigen; D002794:Choline