title: Non-antibiotic properties of tetracyclines and their clinical application in dermatology.
abstract: Dermatologists have used tetracyclines since the 1950s to treat disorders that do not necessarily have an infectious aetiology. Their anti-inflammatory and anti-collagenase properties contribute significantly to their success in treating diseases such as rosacea and acne. This article reviews the non-antibiotic properties of tetracyclines and their clinical application in dermatology.
authors.affiliation: Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
authors.forename: Leanna J
authors.initials: LJ
authors.lastname: Perret
authors.forename: Clare P
authors.initials: CP
authors.lastname: Tait
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000627:therapeutic use*; D010391:Pemphigoid, Bullous / Q000188:drug therapy; D012393:Rosacea / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D013754:Tetracyclines / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D061965:Matrix Metalloproteinase Inhibitors; D013754:Tetracyclines
keywords: anti-inflammatory; dermatology; doxycycline minocycline; matrix metalloproteinase; non-antibiotic; tetracycline