title: Identification and characterization of a twist ortholog in the polychaete annelid Platynereis dumerilii reveals mesodermal expression of Pdu-twist.
abstract: The basic helix-loop-helix transcription factor twist plays a key role during mesoderm development in Bilateria. In this study, we identified a twist ortholog in the polychaete annelid Platynereis dumerilii and analyze its expression during larval development, postlarval growth up to the adult stage, and caudal regeneration after amputation of posterior segments. At late larval stages, Pdu-twist is expressed in the mesodermal anlagen and in developing muscles. During adulthood and caudal regeneration, Pdu-twist is expressed in the posterior growth zone, in mesodermal cells within the newly forming segments and budding parapodia. Our results indicate that Pdu-twist is involved in mesoderm formation during larval development, posterior growth, and caudal regeneration.
authors.affiliation: Institut für Allgemeine und Spezielle Zoologie, Allgemeine Zoologie und Entwicklungsbiologie, Justus-Liebig-Universität Giessen, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Pfeifer
authors.forename: Christoph
authors.initials: C
authors.lastname: Schaub
authors.forename: Georg
authors.initials: G
authors.lastname: Wolfstetter
authors.forename: Adriaan
authors.initials: A
authors.lastname: Dorresteijn
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D004625:Embryo, Nonmammalian / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D008648:Mesoderm / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D011077:Polychaeta / Q000196:embryology* / Q000378:metabolism*; D051879:Twist-Related Protein 1 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D051879:Twist-Related Protein 1