title: [Late-replicating regions in salivary gland polytene chromosomes of Drosophila melanogaster].
abstract: About 240 specific regions that are replicated at the very end of the S-phase have been identified in D. melanogaster polytene chromosomes. These regions have a repressive chromatine state, low gene density, long intergenic distances and are enriched in tissue specific genes. In polytene chromosomes, about a quarter of these regions have no enough time to complete replication. As a result, underreplication zones represented by fewer DNA copy number, appear. We studied 60 chromosome regions that demonstrated the most pronounced under-replication. By comparing the location of these regions on a molecular map with syntenic blocks found earlier for Drosophila species by von Grotthuss et al., 2010, we have shown that across the genus Drosophila, these regions tend to have conserved gene order. This forces us to assume the existence of evolutionary mechanisms aimed at maintaining the integrity of these regions.
authors.forename: T D
authors.initials: TD
authors.lastname: Kolesnikov
authors.forename: N G
authors.initials: NG
authors.lastname: Andreenkova
authors.forename: E S
authors.initials: ES
authors.lastname: Beliaeva
authors.forename: F P
authors.initials: FP
authors.lastname: Goncharov
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Zykova
authors.forename: L V
authors.initials: LV
authors.lastname: Boldyreva
authors.forename: g V
authors.initials: gV
authors.lastname: Pokholkova
authors.forename: I F
authors.initials: IF
authors.lastname: Zhimulev
mesh_terms: D000818:Animals; D004261:DNA Replication / Q000235:genetics*; D004268:DNA-Binding Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D006570:Heterochromatin / Q000235:genetics*; D059007:Polytene Chromosomes / Q000235:genetics*; D012469:Salivary Glands / Q000166:cytology
chemical_list: D004268:DNA-Binding Proteins; D006570:Heterochromatin