title: Novel insights into the pharmacology of flavonoids.
abstract: Flavonoids are widely distributed secondary metabolites and currently consumed in large amounts in the daily diet. In this article, some of the most recent developments in flavonoid - and related polyphenolic compounds - pharmacology are discussed, with particular emphasis on very recent data, most of which are published in Phytotherapy Research, which highlight new aspects in flavonoid anti-inflammatory, antilipidemic, antihyperglycemic, antiviral, hepatoprotective, gastric antiulcer, cardioprotective, neuroprotective, antioxidant and anticancer actions. These updated data confirm the well-established diverse beneficial pharmacological actions and might support the perspective for a therapeutic use.
authors.affiliation: Department of Urology, University of Naples Federico II, via D. Montesano 49, 80131, Naples, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Romano
authors.forename: Ester
authors.initials: E
authors.lastname: Pagano
authors.forename: Vittorino
authors.initials: V
authors.lastname: Montanaro
authors.forename: Alfonso L
authors.initials: AL
authors.lastname: Fortunato
authors.forename: Natasa
authors.initials: N
authors.lastname: Milic
authors.forename: Francesca
authors.initials: F
authors.lastname: Borrelli
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology; D004032:Diet; D005419:Flavonoids / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000494:pharmacology; D059808:Polyphenols / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D000998:Antiviral Agents; D002316:Cardiotonic Agents; D005419:Flavonoids; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D018696:Neuroprotective Agents; D059808:Polyphenols
keywords: antioxidant; apoptosis; cancer; flavonoids; isoflavonoids; phytoestrogens; quercetin; silybin