title: Iodine-131 metaiodobenzylguanidine (I-131 MIBG) diagnosis and therapy of pheochromocytoma and paraganglioma: current problems, critical issues and presentation of a sample case.
abstract: Iodine-131 metaiodobenzylguanidine (I-131 MIBG) has been used for the diagnosis and treatment of malignant pheochromocytomas (PHEO) and paragangliomas (PGL) since 1980's. Despite increasing amount of experience with iodine-131 (I-131) MIBG therapy, many important questions still exist. In this article, we will discuss the current problems learned from clinical experience in diagnosis and therapy of PHEO/PGL with I-131 MIBG, and present a sample case to emphasize the critical aspects for an optimal treatment strategy.
authors.affiliation: Nuclear Medicine Division, Istituto Nazionale Tumori IRCCS Foundation, Milan, Italy. rita.castellani@istitutotumori.mi.it
authors.forename: M R
authors.initials: MR
authors.lastname: Castellani
authors.forename: C
authors.initials: C
authors.lastname: Aktolun
authors.forename: R
authors.initials: R
authors.lastname: Buzzoni
authors.forename: E
authors.initials: E
authors.lastname: Seregni
authors.forename: C
authors.initials: C
authors.lastname: Chiesa
authors.forename: M
authors.initials: M
authors.lastname: Maccauro
authors.forename: G L
authors.initials: GL
authors.lastname: Aliberti
authors.forename: C
authors.initials: C
authors.lastname: Vellani
authors.forename: A
authors.initials: A
authors.lastname: Lorenzoni
authors.forename: E
authors.initials: E
authors.lastname: Bombardieri
mesh_terms: D019797:3-Iodobenzylguanidine / Q000627:therapeutic use*; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine