title: Psychometrics of chronic liver disease questionnaire in Chinese chronic hepatitis B patients.
abstract: OBJECTIVE
  To evaluate psychometrics of the Chinese (mainland) chronic liver disease questionnaire (CLDQ) in patients with chronic hepatitis B (CHB).
  
  
  METHODS
  A cross-sectional sample of 460 Chinese patients with CHB was selected from the Outpatient Department of the Eighth Hospital of Xi'an, including CHB (CHB without cirrhosis) (n = 323) and CHB-related cirrhosis (n = 137). The psychometrics includes reliability, validity and sensitivity. Internal consistency reliability was measured using Cronbach's α. Convergent and discriminant validity was evaluated by item-scale correlation. Factorial validity was explored by principal component analysis with varimax rotation. Sensitivity was assessed using Cohen's effect size (ES), and independent sample t test between CHB and CHB-related cirrhosis groups and between alanine aminotransferase (ALT) normal and abnormal groups after stratifying the disease (CHB and CHB-related cirrhosis).
  
  
  RESULTS
  Internal consistency reliability of the CLDQ was 0.83 (range: 0.65-0.90). Most of the hypothesized item-scale correlations were 0.40 or over, and all of such hypothesized correlations were higher than the alternative ones, indicating satisfactory convergent and discriminant validity. Six factors were extracted after varimax rotation from the 29 items of CLDQ. The eligible Cohen's ES with statistically significant independent sample t test was found in the overall CLDQ and abdominal, systematic, activity scales (CHB vs CHB-related cirrhosis), and in the overall CLDQ and abdominal scale in the stratification of patients with CHB (ALT normal vs abnormal).
  
  
  CONCLUSIONS
  The CLDQ has acceptable reliability, validity and sensitivity in Chinese (mainland) patients with CHB.
authors.affiliation: Department of Epidemiology and Biostatistics, Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Kai-Na
authors.initials: KN
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.forename: Zhen-Hao
authors.initials: ZH
authors.lastname: Ji
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Zhuang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D044466:Asian People / Q000523:psychology; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D016002:Discriminant Analysis; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000208:ethnology / Q000523:psychology; D006801:Humans; D016014:Linear Models; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000208:ethnology / Q000523:psychology / Q000821:virology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D025341:Principal Component Analysis; D011594:Psychometrics; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D015415:Biomarkers; D000410:Alanine Transaminase
keywords: Chronic hepatitis B; Chronic liver disease questionnaire; Reliability; Sensitivity; Validity