title: Oral fluid for the detection of drugs of abuse using immunoassay and LC-MS/MS.
abstract: The utility of oral fluid as a sample matrix for the analysis of drugs has been increasing in popularity over the last few years. This is largely because of collection advantages over other matrices, but also due to the rapid improvements in analytical assays including highly sensitive liquid reagent format enzyme immunoassays and LC-MS/MS. This review will highlight improvements in assay formats, sensitivity, laboratory equipment and sample processing using low sample volumes to expand drug test profiles.
authors.affiliation: Immunalysis Corporation, Pomona, CA 91767, USA. cmoore@immunalysis.com
authors.forename: Christine
authors.initials: C
authors.lastname: Moore
authors.forename: Dennis
authors.initials: D
authors.lastname: Crouch
mesh_terms: D000701:Analgesics, Opioid / Q000032:analysis / Q000652:urine; D002188:Cannabis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003042:Cocaine / Q000032:analysis / Q000652:urine; D006801:Humans; D013287:Illicit Drugs / Q000652:urine*; D007118:Immunoassay; D010622:Phencyclidine / Q000032:analysis / Q000652:urine; D012463:Saliva / Q000737:chemistry; D013048:Specimen Handling / Q000295:instrumentation; D053719:Tandem Mass Spectrometry
chemical_list: D000701:Analgesics, Opioid; D013287:Illicit Drugs; D003042:Cocaine; D010622:Phencyclidine