title: One-step transepithelial topography-guided ablation in the treatment of myopic astigmatism.
abstract: OBJECTIVE
  To evaluate one-step topography-guided transepithelial ablation in the treatment of low to moderate myopic astigmatism using a 1KHz excimer laser.
  
  
  METHODS
  Retrospective study of 117 consecutive eyes available for evaluation 12 months after surgery. Pre- and post-operative visual and refractive data as well as post-operative pain and haze were analyzed. A novel technique integrating custom refractive- and epithelial- ablation in a single uninterrupted procedure was used.
  
  
  RESULTS
  The mean pre-operative spherical equivalent (SE) and the mean cylinder were: -3.22 diopters (D) ±1.54 (SD) (range -0.63 to -7.25 D) and -0.77 D ±0.65 (range 0 to -4.50 D), respectively. At 12 months after surgery: no eyes lost ≥2 lines of corrected distant visual acuity (CDVA). Safety and efficacy indexes were 1.27 and 1.09, respectively. Uncorrected distant visual acuity (UDVA) was ≥20/20 in 96.6% of the eyes. Manifest refraction spherical equivalent was within ±0.5 D of the desired refraction in 93.2% of the eyes. Average root mean square (RMS) wavefront error measured at central 6 mm, increased from 0.38 pre-operatively to 0.47 µm post-operatively. Refractive stability was achieved and sustained 1 month after surgery. No visually significant haze was registered during the observation period. Post-operative pain was reported in 4.5% of patients.
  
  
  CONCLUSIONS
  One-step transepithelial topography-guided treatment for low to moderate myopia and astigmatism performed with a 1 KHz laser, provided safe, effective, predictable and stable results with low pain and no visually significant haze.
authors.affiliation: SynsLaser Kirurgi, Oslo and Tromsø, Norway. aleks@online.no
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Stojanovic
authors.forename: Shihao
authors.initials: S
authors.lastname: Chen
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Chen
authors.forename: Filip
authors.initials: F
authors.lastname: Stojanovic
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: Tor Paaske
authors.initials: TP
authors.lastname: Utheim
mesh_terms: D001251:Astigmatism / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D048988:Corneal Surgery, Laser / Q000379:methods*; D019781:Corneal Topography / Q000009:adverse effects / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies