title: Vitamin D levels in children born to vitamin D-deficient mothers.
abstract: OBJECTIVE
  To determine whether a standard daily dose of 400 IU vitamin D is sufficient to normalize vitamin D levels in infants born to vitamin D-deficient mothers.
  
  
  METHODS
  The children were recruited from a study cohort of 68 immigrant and 51 non-immigrant pregnant women living in Stockholm. The women were monitored at 12 weeks of pregnancy, at delivery and together with their children, 6-18 months after birth. During pregnancy, most immigrant women (78%) had 25(OH)D3 levels <25 nmol/l. We here report the outcome of 25 infants born to these mothers. All infants received a daily supplementation dose of 400 IU vitamin D from 2 weeks of age.
  
  
  RESULTS
  At birth, most children in the immigrant group were vitamin D-deficient (23.3 nmol/l (12-54); mean and range) while at 6-18 months of age vitamin D levels were essentially normalized (82.8 nmol/l (38-142)) although 4 children still had subnormal levels consistent with vitamin D insufficiency.
  
  
  CONCLUSIONS
  A daily recommended supplementation dose of 400 IU vitamin D is sufficient in most children of vitamin D-deficient immigrant women living in Sweden.
authors.affiliation: Division of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Huddinge, Stockholm, Sweden. ingrid.b.bergstrom@karolinska.se
authors.forename: Ingrid
authors.initials: I
authors.lastname: Bergström
authors.forename: Agneta
authors.initials: A
authors.lastname: Blanck
authors.forename: Lars
authors.initials: L
authors.lastname: Sävendahl
mesh_terms: D000328:Adult; D002112:Calcifediol / Q000097:blood* / Q000172:deficiency* / Q000627:therapeutic use; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D013548:Sweden; D014808:Vitamin D Deficiency / Q000178:diet therapy*
chemical_list: D002112:Calcifediol