title: Involvement of human peroxisomes in biosynthesis and signaling of steroid and peptide hormones.
abstract: Although peroxisomes exert essential biological functions, cell type-specific features of this important organelle are still only superficially characterized. An intriguing new aspect of peroxisomal function was recently uncovered by the observation that the peptide hormones β-lipotropin (β-LPH) and β-endorphin are localized to peroxisomes in various human tissues. This suggests a functional link between peptide hormone metabolism and peroxisomes. In addition, because endocrine manifestations that affect steroid hormones are often found in patients suffering from inherited peroxisomal disorders, the question has been raised whether peroxisomes are also involved in steroidogenesis. With this chapter, we will review several crucial aspects concerning peroxisomes and hormone metabolism.
authors.affiliation: Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria, isabelle.weinhofer@meduniwien.ac.at.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Weinhofer
authors.forename: Markus
authors.initials: M
authors.lastname: Kunze
authors.forename: Sonja
authors.initials: S
authors.lastname: Forss-Petter
authors.forename: Johannes
authors.initials: J
authors.lastname: Berger
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism*; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis*; D006066:Gonads / Q000378:metabolism*; D006801:Humans; D036361:Peptide Hormones / Q000096:biosynthesis*; D020675:Peroxisomes / Q000378:metabolism*; D001615:beta-Endorphin / Q000096:biosynthesis; D008083:beta-Lipotropin / Q000096:biosynthesis
chemical_list: D000305:Adrenal Cortex Hormones; D001647:Bile Acids and Salts; D012739:Gonadal Steroid Hormones; D036361:Peptide Hormones; D001615:beta-Endorphin; D008083:beta-Lipotropin