title: Role of oxidative stress in the pathogenesis of alcohol-induced liver disease.
abstract: Chronic alcohol consumption is a well-known risk factor for liver disease, which represents a major cause of morbidity and mortality worldwide. The pathological process of alcohol-induced liver disease is characterized by a broad spectrum of morphological changes ranging from steatosis with minimal injury to more advanced liver damage, including steato-hepatitis and fibrosis/cirrhosis. Experimental and clinical studies increasingly show that the oxidative damage induced by ethanol contribute in many ways to the pathogenesis of alcohol hepatotoxicity. This article describes the contribution of oxidative mechanisms to liver damage by alcohol.
authors.affiliation: Université Catholique de Louvain, Louvain Drug Research Institute, Toxicology and Cancer Biology Research Group (GTOX) , Brussels , Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Sid
authors.forename: J
authors.initials: J
authors.lastname: Verrax
authors.forename: P B
authors.initials: PB
authors.lastname: Calderon
mesh_terms: D000428:Alcohol Drinking / Q000378:metabolism; D000818:Animals; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species