title: The pleiotropic effects and therapeutic potential of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in gastrointestinal tract disorders: a comprehensive review.
abstract: The hydroxy-methyl-glutaryl-CoA reductase inhibitors (statins) are used extensively in the treatment of dyslipidemia, and for the prevention and treatment of coronary artery disease and stroke. They have also demonstrated a benefit in a variety of other disease processes through their non-lipid lowering properties, known as pleiotropic effects. Our paper serves as a focused and updated discussion of the pleiotropic effects of statins in gastrointestinal disorders.
authors.affiliation: Department of Internal Medicine at Mount Sinai Medical Center, Florida, USA.
authors.forename: Mery
authors.initials: M
authors.lastname: Cortes-Bergoderi
authors.forename: Andrés M
authors.initials: AM
authors.lastname: Pineda
authors.forename: Orlando
authors.initials: O
authors.lastname: Santana
mesh_terms: D000818:Animals; D004066:Digestive System Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors