title: Two new acridone alkaloids from the branch of Atalantia buxifolia and their biological activity.
abstract: Two new acridone alkaloids, 3-methoxy-1,4,5-trihydroxy-10-methylacridone (1) and 2,3-dimethoxy-1,4,5-trihydroxy-10-methylacridone (2), were isolated from the ethanol extract of the branch of Atalantia buxifolia. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR. Compounds 1 and 2 exhibited significant antibacterial activity against Staphylococcus aureus and weak inhibitory effect on acetylcholinesterase.
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou , 571101 , China.
authors.forename: Yin-Yu
authors.initials: YY
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Zuo
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Zeng
authors.forename: Shou-Bai
authors.initials: SB
authors.lastname: Liu
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000110:Acetylcholinesterase; D000166:Acridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D054831:Acridones; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C584342:2,3-dimethoxy-1,4,5-trihydroxy-10-methylacridone; C584343:3-methoxy-1,4,5-trihydroxy-10-methylacridone; D000166:Acridines; D054831:Acridones; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; C041300:acridone; D000110:Acetylcholinesterase