title: International cooperation for the cure and prevention of severe hemoglobinopathies.
abstract: Thalassemia major (TM) is the most frequent life-threatening noninfectious disease of childhood in the Middle East, South Asia, and Pacific Islands where it accounts for a significant proportion of childhood mortality, morbidity, and related health care expenses. In spite of major advances in supportive care during the last decade, many patients in low-income and middle-income countries still fare poorly because of high treatment costs and lack of accessible multidisciplinary teams, not to consider the risk of blood-borne infections, primarily hepatitis C. In selected low-risk patients with a compatible sibling, TM is highly curable by bone marrow transplantation (BMT), which also improves the quality of life and is cost-effective. Starting in 2008, the Cure2Children Foundation (C2C), an Italian Non-Governmental Organization, has supported a BMT network in Pakistan, which during 2012 was extended to India. The primary aim of this project was to assess feasibility, outcomes, and costs of matched-related BMT for thalassemia in young low-risk children using a well-established and tolerable strategy. A total of 100 matched-related BMTs have been performed to date by partner institutions within this C2C-supported network; in the 50 low-risk cases with TM, over 90% disease-free survival was obtained with procedure expenses within 10,000 USD/BMT, that is, an outcome comparable to that obtained in affluent countries but with a fraction of the expenses. This cure rate was also obtained in start-up BMT centers (1 in Pakistan and 1 in India) within a structured and intensive cooperation program. Twinning and other international cooperation strategies based on shared principles and a common vision may substantially facilitate access to BMT.
authors.affiliation: The Cure2Children Foundation, Florence, Italy. lawrence.faulkner@cure2children.org
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Faulkner
authors.forename: Cornelio
authors.initials: C
authors.lastname: Uderzo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Masera
mesh_terms: D001208:Asia; D016026:Bone Marrow Transplantation; D003906:Developing Countries; D006801:Humans; D007194:India; D007391:International Cooperation; D008877:Middle East; D010139:Pacific Islands; D010154:Pakistan; D017086:beta-Thalassemia / Q000517:prevention & control* / Q000601:surgery*