title: The influence of skeletal muscle on systemic aging and lifespan.
abstract: Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer's and Parkinson's disease. Here, we review recent studies in mammals and Drosophila highlighting how nutrient- and stress-sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle-derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age-related diseases and contribute to the intertissue communication that underlies systemic aging.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA; Division of Developmental Biology, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
authors.forename: Fabio
authors.initials: F
authors.lastname: Demontis
authors.forename: Rosanna
authors.initials: R
authors.lastname: Piccirillo
authors.forename: Alfred L
authors.initials: AL
authors.lastname: Goldberg
authors.forename: Norbert
authors.initials: N
authors.lastname: Perrimon
mesh_terms: D000818:Animals; D002450:Cell Communication; D016207:Cytokines / Q000378:metabolism; D015444:Exercise; D006801:Humans; D008136:Longevity / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D009928:Organ Specificity
chemical_list: D016207:Cytokines
keywords: exercise; intertissue communication during aging; myokine signaling; skeletal muscle aging; systemic aging