title: Fluorescent multiblock π-conjugated polymer nanoparticles for in vivo tumor targeting.
abstract: Highly fluorescent multiblock conjugated polymer nanoparticles with folic acid surface ligands are highly effective for bioimaging and in vivo tumor targeting. The targeted nanoparticles were preferentially localized in tumor cells in vivo, thereby illustrating their potential for diagnostic and therapeutic applications.
authors.affiliation: Department of Chemistry and Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
authors.forename: Eilaf
authors.initials: E
authors.lastname: Ahmed
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Morton
authors.forename: Paula T
authors.initials: PT
authors.lastname: Hammond
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Swager
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000032:analysis; D005492:Folic Acid / Q000032:analysis; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000032:analysis / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis*; D061848:Optical Imaging / Q000379:methods*; D011108:Polymers / Q000032:analysis; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes; D011108:Polymers; D005492:Folic Acid
keywords: block copolymers; conjugated polymers; fluorescent bioimaging; nanoparticles; tumor targeting