title: Bacteria evade immune recognition via TLR13 and binding of their 23S rRNA by MLS antibiotics by the same mechanisms.
abstract: The immune system recognizes pathogens and other danger by means of pattern recognition receptors. Recently, we have demonstrated that the orphan Toll-like receptor 13 (TLR13) senses a defined sequence of the bacterial rRNA and that bacteria use specific mechanisms to evade macrolide lincosamide streptogramin (MLS) antibiotics detection via TLR13.
authors.affiliation: Department of Research Immunology; Bavarian Nordic GmbH; Martinsried, Germany.
authors.forename: Hubertus
authors.initials: H
authors.lastname: Hochrein
authors.forename: Carsten J
authors.initials: CJ
authors.lastname: Kirschning
keywords: TLR13; antibiotic resistance; bacteria; erythromycin; immune evasion; pattern recognition; rRNA