title: Adrenomedullin signaling pathway polymorphisms and adverse pregnancy outcomes.
abstract: OBJECTIVE
  Reduced maternal plasma levels of the peptide vasodilator adrenomedullin have been associated with adverse pregnancy outcomes. We measured the extent to which genetic polymorphisms in the adrenomedullin signaling pathway are associated with birth weight, glycemic regulation, and preeclampsia risk.
  
  
  METHODS
  We genotyped 1,353 women in the Pregnancy, Infection, and Nutrition Postpartum Study for 37 ancestry-informative markers and for single-nucleotide polymorphisms in adrenomedullin (ADM), complement factor H variant (CFH), and calcitonin receptor-like receptor (CALCRL). We used linear and logistic regression to model the association between genotype and birth weight, glucose loading test (GLT) results, preeclampsia, and gestational diabetes (GDM). All models were adjusted for pregravid body mass index, maternal age, and probability of Yoruban ancestry. p values of < 0.05 were considered statistically significant.
  
  
  RESULTS
  Among Caucasian women, ADM rs57153895, a proxy for rs11042725, was associated with reduced birth weight z-score. Among African-American women, ADM rs57153895 was associated with increased birth weight z-score. Two CALCRL variants were associated with GDM risk. CFH rs1061170 was associated with higher GLT results and increased preeclampsia risk.
  
  
  CONCLUSIONS
  Consistent with studies of plasma adrenomedullin and adverse pregnancy outcomes, we found associations between variants in the adrenomedullin signaling pathway and birth weight, glycemic regulation, and preeclampsia.
authors.affiliation: Department of Cell Biology and Physiology, The University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Lenhart
authors.affiliation: Division of Genetics and Endocrinology, Children's Hospital of Boston, Harvard Medical School, Boston, Massachusetts.
authors.forename: Thutrang
authors.initials: T
authors.lastname: Nguyen
authors.affiliation: Department of Biostatistics, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Alison
authors.initials: A
authors.lastname: Wise
authors.affiliation: Department of Cell Biology and Physiology, The University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Caron
authors.affiliation: Department of Biostatistics, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Amy H
authors.initials: AH
authors.lastname: Herring
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Stuebe
mesh_terms: D000293:Adolescent; D053607:Adrenomedullin / Q000235:genetics*; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D001724:Birth Weight / Q000235:genetics*; D058286:Calcitonin Receptor-Like Protein / Q000235:genetics*; D017242:Complement Factor H / Q000235:genetics*; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005951:Glucose Tolerance Test; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D015398:Signal Transduction; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: C507862:ADM protein, human; C545578:CALCRL protein, human; D058286:Calcitonin Receptor-Like Protein; D053607:Adrenomedullin; D017242:Complement Factor H