title: Up in smoke? A preliminary open-label trial of nicotine replacement therapy and cognitive behavioral motivational enhancement for smoking cessation among youth in Los Angeles.
abstract: In 2008-2009, we conducted a 6-week, open-label trial of transdermal nicotine replacement therapy and practical counseling for 34 adolescents seeking smoking cessation in Los Angeles. Dependent outcomes were study retention, use of the patch, and 7-day quit status at the end-of-study and at follow-up visits. Predictors of outcomes included cigarette dependence, withdrawal symptoms, demographic and psychiatric measures, and other substance use. Variables significant in bivariate analysis (p < .10) were retained in a multivariate model. Subjects had significant pre-to-post reductions in quit rates, dependence, and withdrawal symptoms. Subjects also reported a high number of comorbidities. Implications for clinicians are discussed.
authors.affiliation: 1Department of Family Medicine, UCLA David Geffen School of Medicine , Los Angeles, California , USA.
authors.forename: Aimee-Noelle
authors.initials: AN
authors.lastname: Swanson
authors.forename: Steven
authors.initials: S
authors.lastname: Shoptaw
authors.forename: Keith Gregory
authors.initials: KG
authors.lastname: Heinzerling
authors.forename: Adam C
authors.initials: AC
authors.lastname: Wade
authors.forename: Matthew
authors.initials: M
authors.lastname: Worley
authors.forename: James
authors.initials: J
authors.lastname: McCracken
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Wilson
authors.forename: Joan
authors.initials: J
authors.lastname: Asarnow
authors.forename: Edythe D
authors.initials: ED
authors.lastname: London
mesh_terms: D000293:Adolescent; D015928:Cognitive Behavioral Therapy; D005260:Female; D006801:Humans; D015141:Los Angeles; D008297:Male; D009042:Motivation; D009538:Nicotine / Q000627:therapeutic use*; D016540:Smoking Cessation / Q000379:methods* / Q000523:psychology; D061485:Tobacco Use Cessation Devices; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009538:Nicotine