title: The gallic acid-phospholipid complex improved the antioxidant potential of gallic acid by enhancing its bioavailability.
abstract: Gallic acid (GA) is well known for its antioxidant and hepatoprotective activity, though its effectiveness is restricted due to rapid metabolism and elimination. To overcome these problems, gallic acid-phospholipid complex was prepared and the effect of phospholipid complexation was investigated on carbon tetrachloride (CCl4)-induced oxidative damage in rat liver. The complex significantly reduced the hepatic marker enzymes in rat serum and restored the antioxidant enzyme levels with respect to CCl4-induced group (P < 0.05 and P < 0.01). Also, the complex improved the pharmacokinetics of GA by increasing the relative bioavailability and elimination half-life. The study therefore suggests that phospholipid complexation has enhanced the therapeutic efficacy of GA which may be due to its improved absorption and increased bioavailability in rat serum.
authors.affiliation: School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India.
authors.forename: Sauvik
authors.initials: S
authors.lastname: Bhattacharyya
authors.forename: Sk Milan
authors.initials: SM
authors.lastname: Ahammed
authors.forename: Bishnu Pada
authors.initials: BP
authors.lastname: Saha
authors.forename: Pulok K
authors.initials: PK
authors.lastname: Mukherjee
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005707:Gallic Acid / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008855:Microscopy, Electron, Scanning; D010743:Phospholipids / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000975:Antioxidants; D010743:Phospholipids; D005707:Gallic Acid