title: Dietary phytochemical index and the risk of breast cancer: a case control study in a population of Iranian women.
abstract: In this study we assessed the dietary phytochemical index in relation to the risk of breast cancer in women. This case-control study was conducted on 100 incident breast cancer cases and 175 healthy controls. Data regarding socio-demographic factors, medical history, medications, and anthropometric measurements were collected. Dietary data were obtained using a validated food frequency questionnaire and a energy-adjusted dietary phytochemical index (PI) was calculated. The odds ratios of breast cancer were assessed across energy- adjusted PI quartile categories. The mean age of participants was 46.2±8.9 and 45.9±9.4 years in cases and controls, respectively. The mean PI across quartile categories was 13.9±2.6, 21.1±1.8, 26.7±2.1, 41.6±10.2 in the first, second, third and fourth quartiles, respectively. After adjustment for all potential confounders, the risk of breast cancer in the forth quartile of dietary PI was significantly decreased (OR=0.08, 95%CI=0.01-0.84). Higher intake of phytochemical-rich foods is associated with lower risk of breast cancer.
authors.affiliation: Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Bahadoran
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Karimi
authors.forename: Anahita
authors.initials: A
authors.lastname: Houshiar-rad
authors.forename: Hamid-Reza
authors.initials: HR
authors.lastname: Mirzayi
authors.forename: Bahram
authors.initials: B
authors.lastname: Rashidkhani
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000178:diet therapy / Q000453:epidemiology* / Q000517:prevention & control; D016022:Case-Control Studies; D002523:Edible Grain; D007887:Fabaceae; D005247:Feeding Behavior; D005260:Female; D005638:Fruit; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008875:Middle Aged; D064209:Phytochemicals; D012306:Risk; D011795:Surveys and Questionnaires; D014675:Vegetables
chemical_list: D064209:Phytochemicals