title: Urinary endothellin-1 level in children with pyelonephritis and hydronephrosis.
abstract: Hydronephrosis is a common finding in patients with urinary tract infection (UTI). Endothellin-1 (ET-1) is a potent vasoactive peptide that has vasoconstrictive effects. It has been shown that urinary ET-1 increases in urinary obstructions. In this study, we measured the urinary ET-1 level in patients with UTI and hydronephrosis of various causes. In this case-control study, we evaluated the urinary ET-1 level in 45 patients who had UTI and hydronephrosis, serving as a case group, and 45 patients who had UTI without hydronephrosis, serving as a control group. Urinary ET-1 was quantified using enzyme-linked immunosorbent assay and urinary creatinine (Cr) by Jaffe method. To rule out the effect of urinary flow rate, the urinary ET-1 to Cr correlation was considered for analysis of the results. The mean age of the patients in the case and control groups was 36.5 ± 27.2 and 26.2 ± 15.5 months, respectively (P >0.01). The mean urinary ET-1 was 89.6 ± 41.7 pg/dL in the case group and 29.3 ± 26 pg/dL in the control group, P <0.001. The mean urinary ET-1 was 121 ± 55.4 pg/dL in patients who had grade 4 hydronephrosis. We conclude that urinary ET-1 was significantly higher in the obstructed than in non-obstructed cases. Urinary ET-1 could be a useful marker that can be utilized in young children for diagnosis of hydronephrosis, especially obstructive cases.
authors.affiliation: Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. sharifian.dorche@gmail.com
authors.forename: Mostafa
authors.initials: M
authors.lastname: Sharifian
authors.forename: Mitra
authors.initials: M
authors.lastname: Ahmadi
authors.forename: Abdollah
authors.initials: A
authors.lastname: Karimi
authors.forename: Ranna Esmaili
authors.initials: RE
authors.lastname: Zand
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Moghadar
authors.forename: Roya
authors.initials: R
authors.lastname: Ahmadi
authors.forename: Masoud Dadkhah
authors.initials: MD
authors.lastname: Chimeh
mesh_terms: D016022:Case-Control Studies; D019332:Endothelin-1 / Q000652:urine*; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000150:complications / Q000652:urine*; D007223:Infant; D008297:Male; D011704:Pyelonephritis / Q000150:complications / Q000652:urine*
chemical_list: D019332:Endothelin-1