title: [Cell therapy of critical lower limb ischemia (problems and prospects)].
abstract: Critical limb ischemia is a syndrome that combines several peripheral artery diseases with different ethiology and pathogenesis but with similar prognosis, high morbidity and mortality. Possibility of surgical and conservative treatment of critical limb ischemia almost completely exhausted. Some hopes have arisen due to progress in cell technology. The article provides a critical analysis of pathogenic prerequisites of stem/progenitor cells for the treatment of patients with a critical limb ischemia in detail the basic results of preclinical and clinical studies on the safety and efficacy of cell technology. Unsolved problems and prospects of practical application are also discussed.
authors.forename: S V
authors.initials: SV
authors.lastname: Lebedev
authors.forename: A V
authors.initials: AV
authors.lastname: Karasev
authors.forename: V V
authors.initials: VV
authors.lastname: Kungurtsev
authors.forename: A V
authors.initials: AV
authors.lastname: Lokhonina
authors.forename: E B
authors.initials: EB
authors.lastname: Kleĭmenova
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006801:Humans; D007511:Ischemia / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D007866:Leg / Q000098:blood supply* / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000209:etiology; D033581:Stem Cell Transplantation / Q000379:methods; D013234:Stem Cells / Q000502:physiology