title: Immune Regulation in T1D and T2D: Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment.
abstract: There is increasing evidence that dysregulated immune responses play key roles in the pathogenesis and complications of type 1 but also type 2 diabetes. Indeed, chronic inflammation and autoimmunity, which are salient features of type 1 diabetes, are now believed to actively contribute to the pathogenesis of type 2 diabetes. The accumulation of activated innate and adaptive immune cells in various metabolic tissues results in the release of inflammatory mediators, which promote insulin resistance and β-cell damage. Moreover, these dysregulated immune responses can also mutually influence the prevalence of both type 1 and 2 diabetes. In this review article, we discuss the central role of immune responses in the patho-physiology and complications of type 1 and 2 diabetes, and provide evidence that regulation of these responses, particularly through the action of regulatory T cells, may be a possible therapeutic avenue for the treatment of these disease and their respective complications.
authors.affiliation: Department of Microbiology and Immunology, McGill University , Montreal, QC , Canada ; FOCIS Center of Excellence, Research Institute of the McGill University Health Center , Montreal, QC , Canada.
authors.forename: Mara
authors.initials: M
authors.lastname: Kornete
authors.forename: Edward S
authors.initials: ES
authors.lastname: Mason
authors.forename: Ciriaco A
authors.initials: CA
authors.lastname: Piccirillo
keywords: Foxp3; Treg; diabetes; immune regulation; inflammation; metabolic; obesity