title: Synthesis of 2'-deoxy-9-deaza nucleosides using Heck methodology.
abstract: During the synthesis of a series of 2'-deoxy-9-deaza nucleosides using Heck methodology, the necessity for a pyrrole protecting group was discovered. The results of this brief study revealed that the benzyloxymethyl (BOM) group proved optimal, and Heck coupling using Jeffery conditions increased the coupling yield significantly. The results are reported herein.
authors.affiliation: University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, United States.
authors.forename: Kartik
authors.initials: K
authors.lastname: Temburnikar
authors.forename: Kelin
authors.initials: K
authors.lastname: Brace
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Seley-Radtke
mesh_terms: D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003853:Deoxyribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation
chemical_list: C119904:2'-deoxy-9-deazaguanosine; D003853:Deoxyribonucleosides; D003849:Deoxyguanosine