title: A pharmacologic approach to the use of glyburide in pregnancy.
abstract: Despite widespread use of glyburide to treat pregnancy-related hyperglycemia, the dosing regimen is based in large part on pharmacokinetic and pharmacodynamic studies in men and nonpregnant women. Like many medications used by pregnant women, adequate pharmacokinetic and pharmacodynamic data in pregnancy have been sorely lacking. This lack of information can lead to both overdosing with excessive side effects and underdosing with an inadequate therapeutic response. Both of these problems may apply to glyburide use in pregnancy. This commentary provides a pharmacologic basis for altering the glyburide administration regimen. Taking glyburide 1 hour before a meal may improve efficacy in patients with pregnancy-related hyperglycemia.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and the Department of Pharmacy and Obstetrics & Gynecology, University of Washington, Seattle, Washington, for the Obstetric-Fetal Pharmacology Research Unit Network.
authors.forename: Steve N
authors.initials: SN
authors.lastname: Caritis
authors.forename: Mary F
authors.initials: MF
authors.lastname: Hebert
mesh_terms: D000284:Administration, Oral; D001786:Blood Glucose / Q000187:drug effects; D002096:C-Peptide / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005905:Glyburide / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D007328:Insulin / Q000097:blood; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D005905:Glyburide