title: Filgrastim therapy in a child with neutropenia induced by linezolid.
abstract: We describe the case of a young child with multidrug-resistant tuberculosis, treated with linezolid. The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast recovery of the patient's neutrophil-count. However, more experience with the off-label use of filgrastrim is needed in the pediatric population.
authors.affiliation: Pharmacy Service, Fundación Jiménez Díaz University Hospital, Avenue Reyes Católicos, 2, 28040, Madrid, Spain. mhernandezs@fjd.es
authors.forename: Marta
authors.initials: M
authors.lastname: Hernández Segurado
authors.forename: Maria Ángeles
authors.initials: MÁ
authors.lastname: Arias Moya
authors.forename: Marta
authors.initials: M
authors.lastname: Gómez Pérez
authors.forename: Macarena
authors.initials: M
authors.lastname: Bonilla Porras
authors.forename: Eva
authors.initials: E
authors.lastname: Castillo Bazán
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Bécares Martínez
authors.forename: Gema
authors.initials: G
authors.lastname: Toledano Mayoral
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Panadero Esteban
mesh_terms: D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D000069349:Linezolid; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy*; D056687:Off-Label Use; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012720:Severity of Illness Index; D013997:Time Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D023303:Oxazolidinones; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069349:Linezolid; D000069585:Filgrastim