title: The protective effect of curcumin on ischemia-reperfusion injury in rat ovary.
abstract: BACKGROUND
  To evaluate the protective effects of curcumin in experimental ischemia and ischemia/reperfusion (I/R) injury of rat ovaries.
  
  
  METHODS
  Forty-eight female adult Wistar Albino rats were used. Rats divided into six groups and designed: Sham, Torsion, Detorsion, Sham + Curcumin, Torsion + Curcumin, and Detorsion + Curcumin. Except for the Sham and Sham + Curcumin group, all groups were performed to bilateral adnexal torsion for 3 h. Bilateral adnexal detorsion was implemented in the Detorsion and Detorsion + Curcumin groups. The injection of curcumin was intraperitoneally achieved 30 min before the sham, torsion and detorsion.
  
  
  RESULTS
  Total oxidant status levels (TOS), oxidative stress index (OSI) and histologic scores values of ovarian tissue were higher in the torsion and detorsion groups than the sham group (p < 0.05). There was a strong correlation between the total histologic scores of I/R injury and the OSI (r = 0.809, p < 0.001). By the use of curcumin, a significant decrease was established in the mean levels of oxidant markers and histopathologic scores of the ovarian tissues.
  
  
  CONCLUSIONS
  Administration of curcumin is effective in reversing tissue damage induced by ischemia-reperfusion injury in ovarian torsion.
authors.affiliation: Dicle University, School of Medicine, Department of Obstetrics and Gynecology, Diyarbakır 21280, Turkey. Electronic address: drmesak@yahoo.com.
authors.forename: Muhammet Erdal
authors.initials: ME
authors.lastname: Sak
authors.forename: Hatice Ender
authors.initials: HE
authors.lastname: Soydinc
authors.forename: Sibel
authors.initials: S
authors.lastname: Sak
authors.forename: Mehmet Siddik
authors.initials: MS
authors.lastname: Evsen
authors.forename: Ulas
authors.initials: U
authors.lastname: Alabalik
authors.forename: Fatih
authors.initials: F
authors.lastname: Akdemir
authors.forename: Talip
authors.initials: T
authors.lastname: Gul
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003474:Curcumin / Q000494:pharmacology*; D005260:Female; D010049:Ovarian Diseases / Q000188:drug therapy*; D010053:Ovary / Q000098:blood supply* / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D003474:Curcumin
keywords: Adnexial torsion; Curcumin; Oxidative stress; Rat