title: Lower incidence of hepatic metastases of colorectal cancer in patients with chronic liver diseases: meta-analysis.
abstract: OBJECTIVE
  The rarity of metastatic malignancy in injured liver has been noticed. This meta-analysis evaluates the difference in occurrence of metastatic colorectal cancer in healthy and chronically injured liver.
  
  
  METHODS
  Literature search of occurrence of metastatic colorectal cancer in chronically injured liver opposed to healthy liver was conducted. Chronically injured/damaged liver included cirrhosis, steatosis or fatty liver and infection with Hepatitis virus B or C.
  
  
  RESULTS
  A total of 7 retrospective studies between 1992 and 2010 matched the selection criteria with total of 4049 patients. Results suggest significantly lower incidence of colorectal metastasis in chronically injured liver (Pooled odds ratio = 0.260 (95% CI = 0.18 to 0.38); χ² (test odds ratio differs from 1) = 45.90 (df = 1); p <0.0001).
  
  
  CONCLUSIONS
  Patients with chronic liver injury have significantly lower occurrence of hepatic metastasis of primary colorectal cancer than the patients with healthy liver.
authors.forename: Goran
authors.initials: G
authors.lastname: Augustin
authors.forename: Tomislav
authors.initials: T
authors.lastname: Bruketa
authors.forename: Dragan
authors.initials: D
authors.lastname: Korolija
authors.forename: Milan
authors.initials: M
authors.lastname: Milosevic
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology*; D005234:Fatty Liver / Q000150:complications; D037502:Galectin 3 / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000150:complications; D008107:Liver Diseases / Q000150:complications*; D008113:Liver Neoplasms / Q000453:epidemiology / Q000556:secondary*; D045726:Metalloproteases / Q000502:physiology; D012189:Retrospective Studies; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology
chemical_list: D037502:Galectin 3; D019714:Tissue Inhibitor of Metalloproteinases; D045726:Metalloproteases