title: Subsequent donation requests among 2472 unrelated hematopoietic progenitor cell donors are associated with bone marrow harvest.
abstract: Approximately 1 in 20 unrelated donors are asked to make a second donation of hematopoietic progenitor cells, the majority for the same patient. Anthony Nolan undertook a study of subsequent hematopoietic progenitor cell donations made by its donors from 2005 to 2011, with the aims of predicting those donors more likely to be called for a second donation, assessing rates of serious adverse reactions and examining harvest yields. This was not a study of factors predictive of second allografts. During the study period 2591 donations were made, of which 120 (4.6%) were subsequent donations. The median time between donations was 179 days (range, 21-4016). Indications for a second allogeneic transplant included primary graft failure (11.7%), secondary graft failure (53.2%), relapse (30.6%) and others (1.8%). On multivariate analysis, bone marrow harvest at first donation was associated with subsequent donation requests (odds ratio 2.00, P=0.001). The rate of serious adverse reactions in donors making a subsequent donation appeared greater than the rate in those making a first donation (relative risk=3.29, P=0.005). Harvest yields per kilogram recipient body weight were equivalent between donations, although females appeared to have a lower yield at the subsequent donation. Knowledge of these factors will help unrelated donor registries to counsel their donors.
authors.affiliation: robert.lown@anthonynolan.org.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Lown
authors.forename: Sameer
authors.initials: S
authors.lastname: Tulpule
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Russell
authors.forename: Charles F
authors.initials: CF
authors.lastname: Craddock
authors.forename: Rochelle
authors.initials: R
authors.lastname: Roest
authors.forename: J Alejandro
authors.initials: JA
authors.lastname: Madrigal
authors.forename: Bronwen E
authors.initials: BE
authors.lastname: Shaw
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation / Q000941:ethics* / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000941:ethics* / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D061349:Unrelated Donors / Q000941:ethics* / Q000600:supply & distribution; D055815:Young Adult