title: Mussel oligopeptides ameliorate cognition deficit and attenuate brain senescence in D-galactose-induced aging mice.
abstract: Dietary supplementation exerts beneficial effects in reducing incidence of chronic neurodegenerative diseases. The purpose of this study was to examine protective effects of mussel (Mytilus edulis) oligopeptides supplementation on brain function in D-galactose induced aging mice. Sixty female 8-month-old mice were randomly divided into five groups: vehicle control, D-galactose, and D-galactose combined with 200, 500, 1000 mg/kg mussel oligopeptides. The results showed that mussel oligopeptides could improve cognitive learning and memory ability and protect the hippocampal neurons. In addition, GSH, SOD and GSH-pX activities were increased and MDA level was significantly decreased in mice fed with mussel oligopeptides. It was also found that mussel oligopeptides supplementation prevented D-galactose-induced elevations of iNOS activity and NO production and lactate acid levels in brain. Moreover, PI3K and Akt genes were up-regulated by mussel oligopeptides supplementation. These findings suggest that mussel oligopeptides are able to enhance exercise capacity and protect against oxidative damage caused by D-galactose in aging model mice through regulating oxidation metabolism and PI3K/Akt/NOS signal pathway. Therefore, mussel oligopeptides are good materials for future development of healthcare products to combat age-related brain dysfunction and to improve healthy life span.
authors.affiliation: School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhou
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.forename: Qinggang
authors.initials: Q
authors.lastname: Xu
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: He
authors.forename: Shilei
authors.initials: S
authors.lastname: Tian
authors.forename: Shuyun
authors.initials: S
authors.lastname: Zhu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xiuping
authors.initials: X
authors.lastname: Dong
mesh_terms: D000375:Aging; D000818:Animals; D001522:Behavior, Animal; D056547:CA1 Region, Hippocampal / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D003072:Cognition Disorders / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D004044:Dietary Proteins / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005260:Female; D005690:Galactose; D015227:Lipid Peroxidation; D051379:Mice; D008813:Mice, Inbred ICR; D049880:Mytilus edulis / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use; D018697:Nootropic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D009842:Oligopeptides / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D018384:Oxidative Stress; D011897:Random Allocation; D012758:Shellfish / Q000032:analysis
chemical_list: D004044:Dietary Proteins; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D018697:Nootropic Agents; D009842:Oligopeptides; D005690:Galactose
keywords: Lactate level; Mussel oligopeptides; Oxidative damage; PI3K/Akt/NOS signal; d-Galactose