title: Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis.
abstract: The gaseous plant hormone ethylene regulates a multitude of growth and developmental processes. How the numerous growth control pathways are coordinated by the ethylene transcriptional response remains elusive. We characterized the dynamic ethylene transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment. Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control. EIN3 binding was found to modulate a multitude of downstream transcriptional cascades, including a major feedback regulatory circuitry of the ethylene signaling pathway, as well as integrating numerous connections between most of the hormone mediated growth response pathways. These findings provide direct evidence linking each of the major plant growth and development networks in novel ways. DOI:http://dx.doi.org/10.7554/eLife.00675.001.
authors.affiliation: Plant Biology Laboratory, and Genomic Analysis Laboratory , The Salk Institute for Biological Studies , La Jolla , United States.
authors.forename: Katherine Noelani
authors.initials: KN
authors.lastname: Chang
authors.forename: Shan
authors.initials: S
authors.lastname: Zhong
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Weirauch
authors.forename: Gary
authors.initials: G
authors.lastname: Hon
authors.forename: Mattia
authors.initials: M
authors.lastname: Pelizzola
authors.forename: Hai
authors.initials: H
authors.lastname: Li
authors.forename: Shao-Shan Carol
authors.initials: SS
authors.lastname: Huang
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Schmitz
authors.forename: Mark A
authors.initials: MA
authors.lastname: Urich
authors.forename: Dwight
authors.initials: D
authors.lastname: Kuo
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Nery
authors.forename: Hong
authors.initials: H
authors.lastname: Qiao
authors.forename: Ally
authors.initials: A
authors.lastname: Yang
authors.forename: Abdullah
authors.initials: A
authors.lastname: Jamali
authors.forename: Huaming
authors.initials: H
authors.lastname: Chen
authors.forename: Trey
authors.initials: T
authors.lastname: Ideker
authors.forename: Bing
authors.initials: B
authors.lastname: Ren
authors.forename: Ziv
authors.initials: Z
authors.lastname: Bar-Joseph
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Hughes
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Ecker
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D047369:Chromatin Immunoprecipitation; D005030:Ethylenes / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D005030:Ethylenes; D010937:Plant Growth Regulators; C036216:ethylene
keywords: Arabidopsis; Physcomitrella patens; ethylene; hormone; network; temporal modulation; transcriptional regulation