title: Comparison of a novel, rapid chromogenic biochemical assay, the Carba NP test, with the modified Hodge test for detection of carbapenemase-producing Gram-negative bacilli.
abstract: We compared carbapenemase detection among 271 Gram-negative bacilli (of which 131 were carbapenemase producers) using a novel chromogenic rapid test--the Carba NP test (CNP)--and the modified Hodge test (MHT). Sensitivities were comparable (CNP, 100%, versus MHT, 98%; P = 0.08), but CNP was more specific (100% versus 80%; P < 0.0001) and faster.
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Shawn
authors.initials: S
authors.lastname: Vasoo
authors.forename: Scott A
authors.initials: SA
authors.lastname: Cunningham
authors.forename: Peggy C
authors.initials: PC
authors.lastname: Kohner
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Simner
authors.forename: Jayawant N
authors.initials: JN
authors.lastname: Mandrekar
authors.forename: Karen
authors.initials: K
authors.lastname: Lolans
authors.forename: Mary K
authors.initials: MK
authors.lastname: Hayden
authors.forename: Robin
authors.initials: R
authors.lastname: Patel
mesh_terms: D001426:Bacterial Proteins / Q000032:analysis*; D002863:Chromogenic Compounds / Q000378:metabolism*; D003124:Colorimetry / Q000379:methods*; D006090:Gram-Negative Bacteria / Q000201:enzymology*; D006801:Humans; D012680:Sensitivity and Specificity; D001618:beta-Lactamases / Q000032:analysis*
chemical_list: D001426:Bacterial Proteins; D002863:Chromogenic Compounds; D001618:beta-Lactamases; C063912:carbapenemase