title: A patient-specific planning target volume used in 'plan of the day' adaptation for interfractional motion mitigation.
abstract: We propose a patient-specific planning target volume (PTV) to deal with interfractional variations, and test its feasibility in a retrospective treatment-planning study. Instead of using one planning image only, multiple scans are taken on different days. The target and organs at risk (OARs) are delineated on each images. The proposed PTV is generated from a union of those target contours on the planning images, excluding voxels of the OARs, and is denoted the PTV 'GP-OAR' (global prostate-organs at risk). The study is performed using 'plan of the day' adaptive workflow, which selects a daily plan from a library of plans based on a similarity comparison between the daily scan and planning images. The daily plans optimized for GP-OAR volumes are compared with those optimized for PTVs generated from a single prostate contour (PTV SP). Four CT serials of prostate cancer patient datasets are included in the test, and in total 28 fractions are simulated. The results show that the daily chosen GP-OAR plans provide excellent target coverage, with V95 values of the prostate mostly > 95%. In addition, dose delivered to the OARs as calculated from applying daily chosen GP-OAR plans is slightly increased but comparable to that calculated from applying daily SP plans. In general, the PTV GP-OARs are able to cover possible target variations while keeping dose delivered to the OARs at a similar level to that of the PTV SPs.
authors.affiliation: Universitäts Klinikum Heidelberg, Radiologische Klinik, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. wenjing.chen@med.uni-heidelberg.de
authors.forename: Wenjing
authors.initials: W
authors.lastname: Chen
authors.forename: Alexander
authors.initials: A
authors.lastname: Gemmel
authors.forename: Eike
authors.initials: E
authors.lastname: Rietzel
mesh_terms: D000465:Algorithms; D002244:Carbon / Q000627:therapeutic use; D063193:Heavy Ion Radiotherapy / Q000379:methods*; D006801:Humans; D007477:Ions; D008297:Male; D009038:Motion; D058958:Organs at Risk; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D007477:Ions; D002244:Carbon
keywords: organ motion; particle therapy; planning target volume; prostate; treatment planning