title: The effect of personality disorders on treatment outcomes in patients with obsessive-compulsive disorders.
abstract: The effect of comorbid personality disorders (PD) on treatment outcomes in obsessive-compulsive disorder (OCD) is unclear. The authors systematically review results from investigations of therapy outcomes in adult patients with OCD and a comorbid PD. PsycINFO and MEDLINE were searched for original articles. Twenty-three studies assessing PDs through interviews were selected. Cluster A PDs, particularly schizotypal PD, narcissistic PD, and the presence of two or more comorbid PDs, were associated with poorer treatment outcomes in patients with OCD. With regard to other PDs and clusters, the results are inconsistent or the sample sizes are too small to reach a conclusion. OCD patients with different comorbid PDs differ in their therapeutic response to treatment. To optimize the treatment of OCD, the predictive value of PDs on the treatment outcome should be further investigated, and treatment of Axis I and II comorbidity requires more attention.
authors.forename: Nicola
authors.initials: N
authors.lastname: Thiel
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Hertenstein
authors.forename: Christoph
authors.initials: C
authors.lastname: Nissen
authors.forename: Nirmal
authors.initials: N
authors.lastname: Herbst
authors.forename: Anne Katrin
authors.initials: AK
authors.lastname: Külz
authors.forename: Ulrich
authors.initials: U
authors.lastname: Voderholzer
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy*; D010554:Personality Disorders / Q000453:epidemiology / Q000523:psychology*; D011237:Predictive Value of Tests; D016896:Treatment Outcome