title: Effects of administration of IH901, a ginsenoside intestinal metabolite, on muscular and pulmonary antioxidant functions after eccentric exercise.
abstract: This study was conducted to investigate whether administration of IH901, a ginseng intestinal metabolite, ameliorates exercise-induced oxidative stress while preserving antioxidant defense capability in rat skeletal muscles and lung. Eight adult male Sprague-Dawley rats per group were randomly assigned to the resting control, exercise control, resting with IH901 (25, 50, and 100 mg/kg) consumption (R/IH901), or exercise with IH901 (25, 50, and 100 mg/kg) consumption (E/IH901) group. The trained groups ran 35 min 2 days/week for 8 weeks. To analyze the IH901-training interaction, serum biochemical analysis, lipid peroxidation, citrate synthase, protein oxidation, antioxidant and superoxide dismutase in skeletal muscles and lung tissue were measured. Compared to the exercise control group, animals that consumed IH901 had significantly increased exercise endurance times (p < 0.05) and decreased plasma creatine kinase and lactate dehydrogenase levels (p < 0.05), while those in the E/IH901 groups had increased citrate synthase and anti-oxidant enzymes and decreased lipid peroxidation and protein oxidation (p < 0.05). In conclusion, IH901 consumption in aging rats after eccentric exercise has beneficial effects on anti-inflammatory and anti-oxidant activities through down-regulation of pro-inflammatory mediators, lipid peroxidation, and protein oxidation and up-regulation of anti-oxidant enzymes.
authors.affiliation: Biotoxtech Co. Ltd., Ochang Science Industrial Complex, Ochang 363-883, Korea.
authors.forename: Nam-Jin
authors.initials: NJ
authors.lastname: Lee
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Sung
authors.forename: Yeoung-Gyu
authors.initials: YG
authors.lastname: Ko
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Hwang
authors.forename: Jong-Koo
authors.initials: JK
authors.lastname: Kang
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D005894:Panax / Q000737:chemistry; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012502:Sapogenins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology*; D013047:Specific Pathogen-Free Organisms
chemical_list: C482402:20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol; D000975:Antioxidants; D012502:Sapogenins
keywords: IH901; anti-oxidant activity; eccentric exercise; lipid peroxidation; rat