title: Enantioselective synthesis of pladienolide B and truncated analogues as new anticancer agents.
abstract: An enantioselective synthesis of natural anticancer macrolide pladienolide B is described. The synthetic highlights include Sharpless asymmetric epoxidation, ring closing metathesis (RCM), Ireland-Claisen rearrangement, Shi epoxidation, and Pd-catalyzed Stille coupling as key steps. The synthetic route also allowed the synthesis of the truncated analogues (41a-d) of pladienolide B.
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, India.
authors.forename: Vemula Praveen
authors.initials: VP
authors.lastname: Kumar
authors.forename: Srivari
authors.initials: S
authors.lastname: Chandrasekhar
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010165:Palladium; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D018942:Macrolides; C522342:pladienolide B; D010165:Palladium