title: Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes.
authors.affiliation: Freie Universität Berlin, Institut für Pharmazie, Medizinische Chemie, Königin-Luise-Strasse 2+4, 14195 Berlin, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Arkona
authors.forename: Jörg
authors.initials: J
authors.lastname: Rademann
mesh_terms: D000480:Alkynes / Q000737:chemistry* / Q000494:pharmacology*; D000577:Amides / Q000737:chemistry*; D057056:Cysteine Proteases / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D010293:Pargyline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000480:Alkynes; D000577:Amides; D011480:Protease Inhibitors; D010293:Pargyline; D057056:Cysteine Proteases
keywords: bioorthogonality; irreversible inhibitors; proteases; protein-templated reactions; ubiquitin