title: [Expression of Nusap1 in the surgical margins of hepatocellular carcinoma and its association with early recurrence].
abstract: OBJECTIVE
  To detect the expression of Nusap1 of surgical margins in hepatocellular carcinoma (HCC) and investigate its association with early tumor recurrence.
  
  
  METHODS
  The expression of Nusap1 in the surgical margins of HCC, which were histopathologically negative for tumor cells, was examined using immunohistochemistry in 61 HCC cases.
  
  
  RESULTS
  Fifteen of 21 (71.4%) cases with immunohistochemical positivity for Nusap1 expression in the surgical margins had early recurrence of HCC, a rate significantly higher than that in patients with negative Nusap1 expression (12/40, 30%) (P<0.05).
  
  
  CONCLUSIONS
  Nusap1 expression in the surgical margins of HCC is closely correlated to early postoperative recurrence and can serve as an indicator for predicting early recurrence of HCC.
authors.affiliation: Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. hqzx1234@sohu.com
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.forename: Dinghua
authors.initials: D
authors.lastname: Yang
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Jiankui
authors.initials: J
authors.lastname: Liang
authors.forename: Hua
authors.initials: H
authors.lastname: He
authors.forename: Kebo
authors.initials: K
authors.lastname: Zhong
authors.forename: Liang
authors.initials: L
authors.lastname: Lin
authors.forename: Guogui
authors.initials: G
authors.lastname: Tao
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D055815:Young Adult
chemical_list: D008869:Microtubule-Associated Proteins; C000709213:NUSAP1 protein, human