title: A zinc lock on GGDEF domain dimerization inhibits E. coli biofilms.
abstract: In this issue of Structure, Zähringer and colleagues present crystal structures of an important signal transduction enzyme, diguanylate cyclase DgcZ from E. coli. The authors show that zinc ions bound to the CZB domain inhibit enzyme activity and reveal how zinc availability affects biofilm formation.
authors.affiliation: Department of Molecular Biology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA. gomelsky@uwyo.edu
authors.forename: Mark
authors.initials: M
authors.lastname: Gomelsky
mesh_terms: D018441:Biofilms; D004926:Escherichia coli / Q000201:enzymology*; D029968:Escherichia coli Proteins / Q000737:chemistry*; D019761:Phosphorus-Oxygen Lyases / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D029968:Escherichia coli Proteins; D019761:Phosphorus-Oxygen Lyases; C060720:diguanylate cyclase; D015032:Zinc