title: Determination of remodeling parameters for a strain-adaptive finite element model of the distal ulna.
abstract: Strain energy-based adaptive material models are used to predict bone resorption resulting from stress shielding induced by prosthetic joint implants. Generally, such models are governed by two key parameters: a homeostatic strain-energy state (K) and a threshold deviation from this state required to initiate bone reformation (s). A refinement procedure has been performed to estimate these parameters in the femur and glenoid; this study investigates the specific influences of these parameters on resulting density distributions in the distal ulna. A finite element model of a human ulna was created using micro-computed tomography (µCT) data, initialized to a homogeneous density distribution, and subjected to approximate in vivo loading. Values for K and s were tested, and the resulting steady-state density distribution compared with values derived from µCT images. The sensitivity of these parameters to initial conditions was examined by altering the initial homogeneous density value. The refined model parameters selected were then applied to six additional human ulnae to determine their performance across individuals. Model accuracy using the refined parameters was found to be comparable with that found in previous studies of the glenoid and femur, and gross bone structures, such as the cortical shell and medullary canal, were reproduced. The model was found to be insensitive to initial conditions; however, a fair degree of variation was observed between the six specimens. This work represents an important contribution to the study of changes in load transfer in the distal ulna following the implementation of commercial orthopedic implants.
authors.affiliation: Jack McBain Biomechanical Testing Laboratory, Department of Mechanical & Materials Engineering, Western University, London, ON, Canada.
authors.forename: Mark A C
authors.initials: MA
authors.lastname: Neuert
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Dunning
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000368:Aged; D016723:Bone Remodeling / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology*; D019245:Compressive Strength / Q000502:physiology; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology*; D006801:Humans; D008297:Male; D008954:Models, Biological; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D013314:Stress, Mechanical; D013718:Tensile Strength / Q000502:physiology; D014457:Ulna / Q000000981:diagnostic imaging* / Q000502:physiology*; D014955:Wrist Joint / Q000502:physiology*
keywords: Finite element modeling; biomechanics; bone mechanics; strain-adaptive remodeling