title: Novel 2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides as antioxidant and/or anti-inflammatory compounds.
abstract: A series of novel N-(4-aryl-1,3-thiazol-2-yl)-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides (4a-k) and N-(1,3-benzothiazol-2-yl)-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide derivatives (4l-o) are synthesized and evaluated for their anti-inflammatory and antioxidant activity (DPPH radical scavenging, superoxide anion scavenging, lipid peroxide inhibition, erythrocyte hemolytic inhibition). Compounds 4k and 4l have exhibited good antioxidant activity in four assays, while compounds 4c, 4d, 4m, 4n and 4o have shown good DPPH radical scavenging efficacy. Compounds 4a, 4h, 4i, 4k, 4m and 4n have possessed excellent anti-inflammatory activity. N-[4-(o-methoxyphenyl)-1,3-thiazol-2-yl]-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide (4k) and N-(6-nitro-/methoxy-1,3-benzothiazol-2-yl)-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide (4m and 4n) have exhibited both antioxidant and anti-inflammatory activities.
authors.affiliation: Fluoroorganics Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, Andhra Pradesh, India.
authors.forename: Satish
authors.initials: S
authors.lastname: Koppireddi
authors.forename: Jayaram Reddy
authors.initials: JR
authors.lastname: Komsani
authors.forename: Sreenivas
authors.initials: S
authors.lastname: Avula
authors.forename: Sujitha
authors.initials: S
authors.lastname: Pombala
authors.forename: Satishbabu
authors.initials: S
authors.lastname: Vasamsetti
authors.forename: Srigiridhar
authors.initials: S
authors.lastname: Kotamraju
authors.forename: Rambabu
authors.initials: R
authors.lastname: Yadla
mesh_terms: D000081:Acetamides / Q000737:chemistry* / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D015195:Drug Design; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50
chemical_list: D000081:Acetamides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers
keywords: Anti-inflammatory activity; Erythrocyte hemolysis; Lipid peroxidation; N-(1,3-benzothiazol-2-yl)-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide; N-(4-aryl-1,3-thiazol-2-yl)-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide; Superoxide anion and DPPH radical scavenging