title: Synovial sarcoma presenting with huge mediastinal mass: a case report and review of literature.
abstract: BACKGROUND
  Synovial sarcoma presenting in the mediastinum is exceedingly rare. Furthermore, data addressing optimal therapy is limited. Herein we present a case where an attempt to downsize the tumor to a resectable state with chemotherapy was employed.
  
  
  METHODS
  A 32 year female presented with massive pericardial effusion and unresectable huge mediastinal mass. Computed axial tomography scan - guided biopsy with adjunctive immunostains and molecular studies confirmed a diagnosis of synovial sarcoma. Following three cycles of combination Ifosfamide and doxorubicin chemotherapy, no response was demonstrated. The patient refused further therapy and had progression of her disease 4 months following the last cycle.
  
  
  CONCLUSIONS
  Synovial sarcoma presenting with unresectable mediastinal mass carry a poor prognosis. Up to the best of our knowledge there are only four previous reports where primary chemotherapy was employed, unfortunately; none of these cases had subsequent complete surgical resection. Identification of the best treatment strategy for patients with unresectable disease is warranted. Our case can be of benefit to medical oncologists and thoracic surgeons who might be faced with this unique and exceedingly rare clinical scenario.
authors.affiliation: Department of Medical Oncology, King Hussein Cancer Center, Amman, Jordan. ssalah@khcc.jo
authors.forename: Samer
authors.initials: S
authors.lastname: Salah
authors.forename: Akram
authors.initials: A
authors.lastname: Al-Ibraheem
authors.forename: Amal
authors.initials: A
authors.lastname: Daboor
authors.forename: Maysa
authors.initials: M
authors.lastname: Al-Hussaini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000473:pathology; D055815:Young Adult