title: [Staphylococcal scalded skin syndrome associated with long-term catherter related infection in an adult].
abstract: Staphylococcal scalded skin syndrome (SSSS) is an extensive desquamative erythmatous condition caused by the Staphylococcus aureus exfoliative toxin. Although adult cases of SSSS are rare, the mortality rate is high. We report herein on a case of SSSS due to long-term catheter-related bloodstream infection caused by exfoliative toxin B, which produced methicillin-resistant Staphylococcus aureus. A 64-year-old man was admitted to our hospital with a high fever and generalized exfoliative dermatitis. He had an implanted port vascular access device in his left arm. The port was removed because it was thought to be the focus of infection. A Gram stain of the pus from the incision site revealed Gram positive coccus in clusters, and we administered intravenous vancomycin. MRSA was isolated from blood cultures and the pus, and histiology of a skin biopsy specimen from the exfoliation dermatitis showed epidermal detachment in the uppermost layer, which was consistent with SSSS. Although the patient developed infective endocarditis and septic embolisms, he eventually recovered. PCR of the MRSA was positive for exfoliative toxin B, and we finally diagnosed an adult case of SSSS due to exfoliative toxin B producing MRSA.
authors.affiliation: Disease Control Prevention Center, National Center for Global Health and Medicine.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kutsuna
authors.forename: Kei
authors.initials: K
authors.lastname: Kasahara
authors.forename: Chiyo
authors.initials: C
authors.lastname: Nakagawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Katanami
authors.forename: Taku
authors.initials: T
authors.lastname: Ogawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Uno
authors.forename: Koichi
authors.initials: K
authors.lastname: Maeda
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Konishi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mikasa
mesh_terms: D002405:Catheterization, Central Venous / Q000009:adverse effects*; D005083:Exfoliatins / Q000009:adverse effects*; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D013203:Staphylococcal Infections / Q000382:microbiology*; D013206:Staphylococcal Scalded Skin Syndrome / Q000382:microbiology* / Q000473:pathology
chemical_list: D005083:Exfoliatins