title: A network of interorganellar communications underlies cellular aging.
abstract: Organelles within a eukaryotic cell respond to age-related intracellular stresses and environmental factors by altering their functional states to generate, direct and process the flow of interorganellar information that is essential for establishing a pro- or antiaging cellular pattern. The scope of this review is to critically analyze recent progress in understanding how various intercompartmental (i.e., organelle-organelle and organelle-cytosol) communications regulate cellular aging in evolutionarily distant eukaryotes. Our analysis suggests a model for an intricate network of intercompartmental communications that underly cellular aging in eukaryotic organisms across phyla. This proposed model posits that the numerous directed, coordinated and regulated organelle-organelle and organelle-cytosol communications integrated into this network define the long-term viability of a eukaryotic cell and, thus, are critical for regulating cellular aging.
authors.affiliation: Department of Biology, Concordia University, Montreal, QC, Canada.
authors.forename: Anna
authors.initials: A
authors.lastname: Leonov
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Titorenko
mesh_terms: D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology*; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D008247:Lysosomes / Q000502:physiology; D000076222:Mechanistic Target of Rapamycin Complex 1; D008928:Mitochondria / Q000502:physiology; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism; D015388:Organelles / Q000378:metabolism*; D020675:Peroxisomes / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D014617:Vacuoles / Q000502:physiology
chemical_list: D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases
keywords: an endomembrane system governing cellular aging; biomolecular networks of cellular aging; cell-autonomous mechanisms of organismal aging; cellular aging; interorganellar communications; lysosomes and vacuoles; mitochondria; peroxisomes; signaling network of cellular aging