title: [Electrical properties of retinal ganglion cells of rats with streptozotocine-induced diabetes].
abstract: On isolated retinal preparation from STZ-induced diabetic rats in whole-cell configuration the basic electrical properties of retinal ganglion cells (RGC) were studied. It was shown that on 8th week after STZ maximal depolarization-induced firing frequency is reduced and decay time constant of high-frequency stimulation-induced calcium signals is increased as compared to controls. The data obtained suggest functional changes in RGC of STZ-induced diabetic rats, possible mechanisms of such changes are discussed.
authors.forename: K I
authors.initials: KI
authors.lastname: Kuznetsov
authors.forename: N M
authors.initials: NM
authors.lastname: Veselovs'ka
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Maslov
authors.forename: S A
authors.initials: SA
authors.lastname: Fedulova
authors.forename: M S
authors.initials: MS
authors.lastname: Veselovs'kyĭ
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000502:physiology*; D013311:Streptozocin / Q000494:pharmacology*
chemical_list: D013311:Streptozocin