title: Pregnancy outcomes among women with Marfan syndrome.
abstract: OBJECTIVE
  To determine cardiac and obstetric outcomes among women with Marfan syndrome (MS) whose pregnancies were managed in accordance with the French national guidelines.
  
  
  METHODS
  A descriptive analysis was conducted for a prospective cohort of 18 women with MS who gave birth in the maternity unit of Bichat-Claude Bernard Hospital, Paris, France, between January 1, 1998, and May 31, 2011. The study hospital was the national referral center for MS and related diseases.
  
  
  RESULTS
  A total of 22 pregnancies were recorded among the study cohort. Of these, 21 were managed according to the national guidelines. One woman who was referred to the study hospital during late pregnancy was not managed according to the national guidelines; this patient experienced aortic dissection at 37 weeks. In the cohort, aortic diameter did not increase significantly during pregnancy. Vascular fetal growth restriction was observed in 7 (31.8 %) of the pregnancies. Cesarean delivery was planned for 17 (77.3%) of the pregnancies.
  
  
  CONCLUSIONS
  Risk of aortic dissection was low among a cohort of pregnant women with MS who were managed according to the French national guidelines.
authors.affiliation: Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital, Université Paris 7, AP-HP, Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Omnes
authors.forename: Guillaume
authors.initials: G
authors.lastname: Jondeau
authors.forename: Delphine
authors.initials: D
authors.lastname: Detaint
authors.forename: Agathe
authors.initials: A
authors.lastname: Dumont
authors.forename: Chadi
authors.initials: C
authors.lastname: Yazbeck
authors.forename: Jean
authors.initials: J
authors.lastname: Guglielminotti
authors.forename: Dominique
authors.initials: D
authors.lastname: Luton
authors.forename: Elie
authors.initials: E
authors.lastname: Azria
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000453:epidemiology / Q000209:etiology; D001011:Aorta / Q000473:pathology; D001014:Aortic Aneurysm / Q000453:epidemiology / Q000209:etiology; D002585:Cesarean Section / Q000706:statistics & numerical data; D015331:Cohort Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000209:etiology; D005602:France; D006801:Humans; D008382:Marfan Syndrome / Q000150:complications* / Q000628:therapy; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology* / Q000628:therapy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D055815:Young Adult
keywords: Aortic dissection; Fetal growth restriction; Marfan syndrome; National guidelines; Pregnancy; β-blocker