title: Visit-to-visit variability in systolic blood pressure is a novel risk factor for the progression of coronary artery calcification.
abstract: Recent studies have suggested that variability in the systolic blood pressure (SBP) is a risk factor for cardiovascular disease (CVD). The aim of this study was to investigate the relationship between variability in the SBP and the progression of coronary artery calcification (CAC), which is a useful marker for CVD. We measured SBP in 164 consecutive patients at every visit over the course of a year and calculated the coefficient of variation and s.d. of the SBP. We performed a follow-up study using multislice computed tomography to assess the progression of the CAC score, the mean interval of which was 3.93 ± 1.36 years. We then evaluated the relationship between variability in the SBP and progression of the CAC score. The coefficient of variation for the SBP correlated positively with the progression of the CAC score (r=0.4382, P<0.0001). Multiple regression analysis demonstrated that the coefficient of variation of the SBP (β=0.3826, P<0.0001) was independently associated with the progression of the CAC score. The visit-to-visit variability in SBP could be a novel risk factor for the progression of CAC.
authors.affiliation: Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okada
authors.forename: Michiaki
authors.initials: M
authors.lastname: Fukui
authors.forename: Muhei
authors.initials: M
authors.lastname: Tanaka
authors.forename: Shinobu
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Mineoka
authors.forename: Naoko
authors.initials: N
authors.lastname: Nakanishi
authors.forename: Ki-Ichiro
authors.initials: K
authors.lastname: Tomiyasu
authors.forename: Koji
authors.initials: K
authors.lastname: Nakano
authors.forename: Goji
authors.initials: G
authors.lastname: Hasegawa
authors.forename: Naoto
authors.initials: N
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D002114:Calcinosis / Q000473:pathology* / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors