title: Can resistin be a new indicator of neonatal sepsis?
abstract: BACKGROUND
  Sepsis is an important cause of neonatal death and perinatal brain damage, particularly in preterm infants. It is thought that activation of the inflammatory cascade triggered by cytokine might play a role in the pathogenesis of sepsis. Recent evidence supports a role for resistin in inflammation. There are no data in the literature on resistin levels of premature newborns with sepsis, which can also cause inflammatory response. The objective of this study was to evaluate whether resistin can be used as an indicator in neonatal sepsis of preterm babies.
  
  
  METHODS
  Forty-three premature newborns considered to have sepsis were included in the study. Forty-three gestational and postnatal age- and sex-matched premature newborns without premature prolonged rupture of membrane or sepsis served as controls.
  
  
  RESULTS
  The median resistin and interleukin-6 (IL-6) levels of the premature babies with sepsis were 85.9 ng/mL and 342.7 pg/mL, respectively, and were higher than those of the control group (29.9 ng/mL and 17.7 pg/mL, respectively). The sensitivity, specificity, positive, and negative predictive values for resistin were 73.7%, 45.8%, 68.3%, and 52.4%, respectively.
  
  
  CONCLUSIONS
  Resistin levels were higher in premature newborns with sepsis and correlated with IL-6 levels, which is an indicator of neonatal sepsis. This suggests that resistin may also be used in the diagnosis of neonatal sepsis. However, it has limited value when compared with the other inflammatory markers including C-reactive protein, procalcitonin, and IL-6.
authors.affiliation: Pediatrics and Biochemistry Department, Kırıkkale University Medical Faculty, Kırıkkale, Turkey. Electronic address: didem.aliefendioglu@gmail.com.
authors.forename: Didem
authors.initials: D
authors.lastname: Aliefendioglu
authors.affiliation: Zeynep Kamil Maternity and Children's Education and Training Hospital, NICU, Istanbul, Turkey.
authors.forename: Tuğba
authors.initials: T
authors.lastname: Gürsoy
authors.affiliation: Pediatrics and Biochemistry Department, Kırıkkale University Medical Faculty, Kırıkkale, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Çağlayan
authors.affiliation: Zeynep Kamil Maternity and Children's Education and Training Hospital, NICU, Istanbul, Turkey.
authors.forename: Alev
authors.initials: A
authors.lastname: Aktaş
authors.affiliation: Zeynep Kamil Maternity and Children's Education and Training Hospital, NICU, Istanbul, Turkey.
authors.forename: Fahri
authors.initials: F
authors.lastname: Ovalı
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D011498:Protein Precursors / Q000097:blood; D052243:Resistin / Q000097:blood*; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D015850:Interleukin-6; D011498:Protein Precursors; C499624:RETN protein, human; D052243:Resistin; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide
keywords: C-reactive protein; interleukin-6; premature; procalcitonin; resistin; sepsis