title: Lack of association between the haplotype GCC/ATA polymorphism in the IL-10 promoter and SLE risk: evidence from a meta-analysis.
abstract: Numerous studies have investigated the association between the interleukin (IL)-10 promoter haplotype GCC/ATA (at the - 1082, - 819 and - 592 positions of the IL-10 gene) polymorphism and systemic lupus erythematosus (SLE) risk, but the results were inconsistent. We performed the current meta-analysis to assess precisely the association by comparing the GCC haplotype with the ATA haplotype. A literature search was conducted using Pubmed and Web of Science databases. Twelve studies including 1765 cases and 2444 controls were included in this meta-analysis. The overall odds ratios (total and stratified by ethnicity: Asian or Caucasian) were 1.042 (95 % confidence interval [CI] 0.893-1.216; p = 0.599), 0.790 (95 % CI 0.528-1.182; p = 0.251), and 1.093 (95 % CI 0.919-1.300; p = 0.317), respectively. The results indicated that the GCC haplotype revealed no statistically significant association with SLE risk; thus, the haplotype GCC/ATA polymorphism of the IL-10 promoter is not likely to be involved in SLE susceptibility.
authors.affiliation: Department of Epidemiology and Biostatistics, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, China.
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: Y-G
authors.initials: YG
authors.lastname: Fan
authors.forename: D-Q
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D019317:Evidence-Based Medicine; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10