title: Neuroendocrinology: regulated secretory cells go to the BAR for a bud.
abstract: Syndromes caused by insufficient secretion of peptide hormones originate either from an inadequate population of endocrine secretory cells or from deficiencies in the secretory process. Two remarkable new studies highlight the importance of PICK1 and ICA69 in creating the protein storage organelles needed for regulated exocytosis, independent of stimulus-secretion coupling.
authors.forename: Peter
authors.initials: P
authors.lastname: Arvan
authors.forename: David
authors.initials: D
authors.lastname: Castle
mesh_terms: D001324:Autoantigens / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D009452:Neuroendocrinology / Q000379:methods*; D009687:Nuclear Proteins / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism*
chemical_list: D001324:Autoantigens; D002352:Carrier Proteins; C087054:ICA1 protein, human; D009687:Nuclear Proteins; C498297:PICk1 protein, human