title: Association between serum interleukin-6 concentration and mortality in patients with coronary artery disease.
abstract: OBJECTIVE
  To evaluate whether serum interleukin-6 (IL-6) is associated with increased risk of mortality in coronary artery disease (CAD) patients.
  
  
  METHODS
  We performed a prospective cohort study of 718 CAD patients from the Guangzhou Cardiovascular Disease Cohort (GCDC) study. Multivariable-adjusted Cox proportional hazards regression analyses were used to examine the association between serum IL-6 with all-cause and cardiovascular mortality.
  
  
  RESULTS
  During the 1663 person-years of followup, the cumulative all-cause mortality and cardiovascular mortality were 6.5% (n = 47) and 3.3% (n = 24), respectively. The mean length of followup was 2.32 ± 0.81 years. In the multivariable analyses, a one-SD increment in log-transformed serum IL-6 was positively associated with an increased risk of all-cause and cardiovascular mortality, with hazard ratios (HR) of 2.93 (95% CI, 2.11-4.08) and 2.04 (95% CI, 1.34-3.68) within the patients combined and 2.98 (95% CI, 2.12-4.18) and 3.10 (95% CI, 1.98-4.85) within males, respectively. Patients in the highest serum IL-6 tertile versus the lowest tertile were at higher risk of all-cause and cardiovascular mortality, with HR of 17.12 (95% CI 3.11-71.76) and 8.68 (95% CI, 1.88-37.51), respectively.
  
  
  CONCLUSIONS
  In hospitalized patients with CAD, serum IL-6 is significantly associated with all-cause and cardiovascular mortality.
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
authors.forename: Dongfang
authors.initials: D
authors.lastname: Su
authors.forename: Zhongxia
authors.initials: Z
authors.lastname: Li
authors.forename: Xinrui
authors.initials: X
authors.lastname: Li
authors.forename: Yuming
authors.initials: Y
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ding
authors.initials: D
authors.lastname: Ding
authors.forename: Xueqing
authors.initials: X
authors.lastname: Deng
authors.forename: Min
authors.initials: M
authors.lastname: Xia
authors.forename: Jian
authors.initials: J
authors.lastname: Qiu
authors.forename: Wenhua
authors.initials: W
authors.lastname: Ling
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000097:blood* / Q000401:mortality*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha