title: 11β-HSD1 inhibitors from Walsura cochinchinensis.
abstract: A search for inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) from Walsura cochinchinensis yielded 10 new limonoids, cochinchinoids A-J (1-10), and two new triterpenoids, 3-epimesendanin S (11) and cochinchinoid K (12). Their structures were assigned on the basis of spectroscopic data, with the absolute configurations of 1 and 12 being established by X-ray diffraction analysis. Of these compounds, cochinchinoid K (12) displayed inhibitory activity against mouse 11β-HSD1 with an IC50 value of 0.82 μM.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Han
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Leng
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors*; D000818:Animals; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009765:Obesity; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D036701:Limonins; D014315:Triterpenes; C584073:cochinchinoid K; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1