title: Immune effects of 5-fluorouracil: Ambivalence matters.
abstract: Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting TH17 responses that compromise anticancer immunity. This underscores the need to combine 5-FU with NLRP3 inhibitors to prevent tumor progression.
authors.affiliation: INSERM, U866; Dijon, France ; Centre Georges François Leclerc; Dijon, France ; Université de Bourgogne; Dijon, France.
authors.forename: François
authors.initials: F
authors.lastname: Ghiringhelli
authors.forename: Melanie
authors.initials: M
authors.lastname: Bruchard
authors.forename: Lionel
authors.initials: L
authors.lastname: Apetoh
keywords: IL1; NLRP3; fluorouracil; inflammasome; myeloid derived suppressor cells