title: A new strategy to target regulatory T cells in solid tumors.
abstract: The depletion of regulatory T cells (Tregs) is a promising therapeutic strategy to enhance antitumor immune responses. Our recent findings indicate that low doses of arsenic trioxide can delay tumor growth in murine models of colon and breast cancer by depleting Tregs through oxidative and nitrosative bursts.
authors.affiliation: Université Paris Descartes ; Unité de Formation et de Recherche des Sciences Pharmaceutiques et Biologiques; Paris, France ; Université Paris Descartes; Sorbonne Paris Cité; Faculté de Médecine; Paris, France ; Unité Fonctionnelle de Pharmacocinétique et Pharmacochimie; Assistance Publique-Hôpitaux de Paris; Hôpital Cochin; Paris, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Thomas-Schoemann
authors.forename: Frédéric
authors.initials: F
authors.lastname: Batteux
authors.forename: Jérôme
authors.initials: J
authors.lastname: Alexandre
keywords: arsenic trioxide; breast cancer; colon cancer; nitrosative stress; oxidative stress; regulatory T cell