title: HINTEGRA total ankle replacement: survivorship analysis in 684 patients.
abstract: BACKGROUND
  Total ankle replacement is increasingly recommended for patients with end-stage ankle osteoarthritis. We analyzed the survivorship of 722 arthroplasties performed with one type of three-component total ankle prosthesis.
  
  
  METHODS
  Seven hundred and seventy-nine primary total ankle arthroplasties (741 patients) were performed between May 2000 and July 2010 with use of the HINTEGRA three-component prosthesis. A logistic multiple regression model was used to identify independent risk factors for prosthesis failure in 684 patients (722 ankles). The mean time to final follow-up (and standard deviation) was 6.3 ± 2.9 years.
  
  
  RESULTS
  Seven hundred and twenty-two ankles (684 patients) were available for survivorship analysis at the latest follow-up. The overall survival rates were 94% and 84% after five and ten years, respectively. Sixty-one ankles had a revision arthroplasty (twenty-seven both components, thirteen the tibial component only, and fourteen the talar component only) or were converted to a fusion (seven ankles).There were no polyethylene failures. There were no amputations. The generation category of the prosthesis, the cause of ankle osteoarthritis, and the age of the patient were identified as independent risk factors for prosthesis failure.
  
  
  CONCLUSIONS
  The midterm survivorship of the HINTEGRA implant was comparable with that of other third-generation total ankle replacements.
authors.affiliation: Orthopaedic Department, University Hospital of Basel, University of Basel, Spitalstrasse 21, CH-4031 Basel, Switzerland. alexejbarg@mail.ru
authors.forename: Alexej
authors.initials: A
authors.lastname: Barg
authors.forename: Lukas
authors.initials: L
authors.lastname: Zwicky
authors.forename: Markus
authors.initials: M
authors.lastname: Knupp
authors.forename: Heath B
authors.initials: HB
authors.lastname: Henninger
authors.forename: Beat
authors.initials: B
authors.lastname: Hintermann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000843:Ankle Joint / Q000601:surgery*; D019643:Arthroplasty, Replacement / Q000295:instrumentation*; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D007595:Joint Prosthesis; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D012307:Risk Factors; D055815:Young Adult