title: Safety, tolerability, and efficacy of oral therapies for relapsing-remitting multiple sclerosis.
abstract: Treatment options for relapsing-remitting multiple sclerosis (RRMS) have been continuously expanding in recent years, and the emergence of a number of oral disease-modifying agents (DMAs) has significantly changed the landscape of therapeutic options for MS patients. Many of these oral DMAs have demonstrated satisfactory safety and tolerability profiles in clinical trial settings, but the long-term safety of these agents is an important concern. This review discusses salient points on the safety and clinical efficacy of the approved and emerging novel oral therapies in RRMS, including fingolimod, teriflunomide, dimethyl fumarate, laquinimod, and cladribine.
authors.affiliation: Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. jioh@jhsph.edu
authors.forename: Jiwon
authors.initials: J
authors.lastname: Oh
authors.forename: Paul W
authors.initials: PW
authors.lastname: O'Connor
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002986:Clinical Trials as Topic; D015195:Drug Design; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents