title: Esthesioneuroblastoma of the nasal cavity.
abstract: OBJECTIVE
  Esthesioneuroblastoma is an uncommon cancer of the nasal cavity. We describe the outcomes for 26 patients treated with curative intent with photon radiotherapy (RT) at the University of Florida.
  
  
  METHODS
  Between May 1972 and June 2007, 26 patients received RT for previously untreated esthesioneuroblastoma of the nasal cavity. Sixteen patients were males and 10 were females with a median age of 55 years (range, 3 to 82 y). The modified Kadish stage distribution was: B, 7 patients; C, 17 patients; and D, 2 patients. Treatment modalities included the following: definitive RT, 5 patients; preoperative RT, 2 patients; and postoperative RT after resection, 19 patients. Elective neck irradiation (ENI) was performed in 17 (71%) of 24 N0 patients.
  
  
  RESULTS
  Rates of local control, cause-specific survival, and absolute overall survival at 5 years were 79%, 72%, and 69%, respectively. Overall survival among patients treated with definitive RT was 20% at 5 years, compared with 81% among those who underwent surgery and adjuvant RT (P=0.01). One (6%) of 17 patients who received ENI developed a recurrence in the neck and was successfully salvaged. Ultimate neck control was 100% at 5 years for patients who received ENI versus 69% among those not receiving ENI (P=0.0173).
  
  
  CONCLUSIONS
  Resection combined with adjuvant RT is more effective than surgery or RT alone in the treatment of esthesioneuroblastoma. ENI reduces the risk of regional relapse in patients with Kadish stage B and C cancers.
authors.affiliation: Departments of *Radiation Oncology †Otolaryngology, University of Florida College of Medicine, Gainesville, FL.
authors.forename: Tyler R
authors.initials: TR
authors.lastname: Hollen
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Morris
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Kirwan
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Amdur
authors.forename: John W
authors.initials: JW
authors.lastname: Werning
authors.forename: Mikhail
authors.initials: M
authors.lastname: Vaysberg
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D018304:Esthesioneuroblastoma, Olfactory / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009333:Neck; D009669:Nose Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D017785:Photons; D011183:Postoperative Complications; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult