title: Geometrical and volume changes of the membranous vestibular labyrinth in guinea pigs with endolymphatic hydrops.
abstract: OBJECTIVE
  To evaluate geometrical and volume changes of membranous vestibular labyrinths in guinea pigs after endolymphatic hydrops (EH).
  
  
  METHODS
  The membranous labyrinths of normal guinea pigs and of those with EH for 4 and 8 weeks were reconstructed after being scanned using micro-computed tomography subseqent to being stained in osmium tetroxide (OsO4). The diameters and volumes of the semicircular ducts, ampullae, utricles and saccules were measured based on the three-dimensional models.
  
  
  RESULTS
  The diameters of the ampullae and utricles of EH guinea pigs were greater than those of the normal guinea pigs, while there were no significant differences in the diameters of the semicircular ducts among all groups. The volumes of ampullae, utricles and saccules of the EH groups were greater than those of the control group, but there were no changes in volumes of semicircular ducts after EH.
  
  
  CONCLUSIONS
  The dilations of the membranous vestibular labyrinth in guinea pigs with EH mainly occur at the ampullae, utricles and saccules.
authors.affiliation: Eye & ENT Hospital, Fudan University, Shanghai, China.
authors.forename: Caiqin
authors.initials: C
authors.lastname: Wu
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Cheng
authors.initials: C
authors.lastname: Hua
authors.forename: Keqiang
authors.initials: K
authors.lastname: Wang
authors.forename: Tianyu
authors.initials: T
authors.lastname: Zhang
authors.forename: Peidong
authors.initials: P
authors.lastname: Dai
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007758:Ear, Inner / Q000000981:diagnostic imaging* / Q000473:pathology*; D018159:Endolymphatic Hydrops / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006168:Guinea Pigs; D054777:Hair Cells, Ampulla / Q000000981:diagnostic imaging / Q000473:pathology; D021621:Imaging, Three-Dimensional; D008297:Male; D008575:Meniere Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D009759:Nystagmus, Pathologic / Q000000981:diagnostic imaging / Q000473:pathology; D012444:Saccule and Utricle / Q000000981:diagnostic imaging / Q000473:pathology; D054776:Semicircular Ducts / Q000000981:diagnostic imaging / Q000473:pathology; D055114:X-Ray Microtomography