title: Low-molecular-weight adiponectin and high-molecular-weight adiponectin levels in relation to diabetes.
abstract: OBJECTIVE
  To evaluate the association between adiponectin complexes (high-molecular-weight [HMW], middle-molecular-weight [MMW], and low-molecular-weight [LMW] adiponectin) and diabetes.
  
  
  METHODS
  We conducted a case-control study, based on a cohort in Saku, Japan. Among 2565 participants, 300 participants with diabetes and 300 matched controls (430 men and 170 women) were analyzed.
  
  
  RESULTS
  After adjusting for age, physical activity, hypertension, family history, alcohol use, smoking, and menopausal status, total, HMW, and LMW, but not MMW adiponectin levels were inversely associated with diabetes: total adiponectin, odds ratio comparing the highest with the lowest quartiles, 0.46 (95% confidence interval, 0.25-0.82; P for trend = 0.046); HMW, 0.40 (95%CI, 0.22-0.72; P = 0.046); MMW, 1.04 (95%CI, 0.60-1.77; P = 0.81); and LMW, 0.51 (95%CI, 0.29-0.89; P = 0.01). The associations between total and HMW adiponectin and diabetes attenuated after adjustment for BMI (P = 0.15 and 0.13, respectively), but LMW remained (P = 0.04). When stratified by sex, LMW adiponectin levels were associated with diabetes in men only. None of the associations were significant after adjustment for HOMA-IR.
  
  
  CONCLUSIONS
  Decreased LMW, total, and HMW adiponectin levels are associated with diabetes. These associations may be secondary to adiposity or insulin resistance.
authors.affiliation: Department of Diabetes Research, Diabetes Research Center National Center for Global Health and Medicine, Tokyo, Japan; Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, Yokohama, Japan; National Institute of Health and Nutrition, Tokyo, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Goto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Goto
authors.forename: Akemi
authors.initials: A
authors.lastname: Morita
authors.forename: Kijo
authors.initials: K
authors.lastname: Deura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Naomi
authors.initials: N
authors.lastname: Aiba
authors.forename: Takuro
authors.initials: T
authors.lastname: Shimbo
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Terauchi
authors.forename: Motohiko
authors.initials: M
authors.lastname: Miyachi
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
authors.forename: Shaw
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D050154:Adiposity; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000208:ethnology / Q000628:therapy; D015536:Down-Regulation; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006769:Hospitals, General; D006801:Humans; D007333:Insulin Resistance; D007564:Japan; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D015203:Reproducibility of Results; D012727:Sex Characteristics
chemical_list: D052242:Adiponectin; D006442:Glycated Hemoglobin; C499918:ADIPOQ protein, human; C517652:hemoglobin A1c protein, human