title: Combined wavefront-guided laser in situ keratomileusis and aspheric ablation profile with iris registration to correct myopia.
abstract: OBJECTIVE
  To compare the effects of a combined wavefront-guided and aspheric ablation profile with an aspheric ablation profile alone to correct myopia in patients with a preoperative total higher-order aberration root mean square (HOA RMS) lower than 0.30 μm in both eyes.
  
  
  METHODS
  Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
  
  
  METHODS
  Comparative case series.
  
  
  METHODS
  Laser in situ keratomileusis was performed, with 1 eye randomized to wavefront-guided with aspheric ablation and the fellow eye to aspheric ablation only. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, manifest subjective refraction, corneal topography, RMS value of total and grouped HOAs, and contrast sensitivity were measured preoperatively and 1 and 6 months postoperatively.
  
  
  RESULTS
  The study enrolled 62 eyes (31 patients). The increasing factors of total HOA RMS, 3rd-order RMS and 4th-order RMS were 2.09, 2.09, and 1.99, respectively, in the wavefront-guided with aspheric ablation group and 2.52, 2.68, and 2.51, respectively, in the aspheric ablation only group at 6 months; the aspheric ablation group had statistically significantly larger increasing factors (P=.016, P=.038, and P=.027, respectively). The reduction in contrast sensitivity log values was statistically significantly less in the wavefront-guided with aspheric ablation group than in the aspheric ablation only group except at 1.5 cycles per degree.
  
  
  CONCLUSIONS
  The wavefront-guided with aspheric ablation profile was associated with better limitation of HOAs and faster recovery of mesopic contrast sensitivity for patients with a preoperative total HOA RMS lower than 0.30 μm.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Hainan Eye Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Junshu
authors.initials: J
authors.lastname: Wu
authors.forename: Xingwu
authors.initials: X
authors.lastname: Zhong
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Keming
authors.initials: K
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D001251:Astigmatism / Q000503:physiopathology / Q000601:surgery*; D015350:Contrast Sensitivity / Q000502:physiology; D019781:Corneal Topography; D057108:Corneal Wavefront Aberration / Q000503:physiopathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications; D007498:Iris / Q000033:anatomy & histology*; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D054018:Lasers, Excimer / Q000627:therapeutic use*; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult