title: Angiogenic nanodelivery systems for myocardial therapy.
abstract: Despite outstanding progress in the area of cardiovascular diseases, significant challenges remain in designing efficient delivery systems for myocardial therapy. Nanotechnology provides the tools to explore such frontiers of biomedical science at cellular level and thus offers unique features for potential application in the field of cardiac therapy. This chapter focuses on the methodology, based on the work done in our lab, to prepare and investigate two kinds of biocompatible nanoparticles (NPs) that can be useful for sustained delivery of single or multiple angiogenic growth factors to damaged sites, such as in myocardially infarcted heart to promote myocardial angiogenesis and reduce scar area.
authors.affiliation: Department of Biomedical Engineering, Biomedical Technology and Cell Therapy Research Laboratory, Artificial Cells and Organs Research Centre, McGill University, Montreal, QC, Canada.
authors.forename: Arghya
authors.initials: A
authors.lastname: Paul
authors.forename: Dominique
authors.initials: D
authors.lastname: Shum-Tim
authors.forename: Satya
authors.initials: S
authors.lastname: Prakash
mesh_terms: D000418:Albumins / Q000737:chemistry; D000464:Alginates / Q000378:metabolism; D042501:Angiogenic Proteins / Q000378:metabolism*; D049109:Cell Proliferation; D002478:Cells, Cultured; D016503:Drug Delivery Systems; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D020723:Glucuronic Acid / Q000378:metabolism; D006603:Hexuronic Acids / Q000378:metabolism; D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism / Q000628:therapy*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000418:Albumins; D000464:Alginates; D042501:Angiogenic Proteins; D006603:Hexuronic Acids; D020723:Glucuronic Acid