title: Seeking the origin of female germline stem cells in the mammalian ovary.
abstract: The function of female germline stem cells (FGSCs, also called oogonial stem cells) in the adult mammalian ovary is currently debated in the scientific community. As the evidence to support or discard the possible crucial role of this new class of germ cells in mammals has been extensively discussed, in this review, we wonder which could be their origin. We will assume that FGSCs are present in the post-natal ovaries and speculate as to what origin and characteristics such cells could have. We believe that the definition of these features might shed light on future experimental approaches that could clarify the ongoing debate.
authors.affiliation: Section of Histology and Embryology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. defelici@uniroma2.it
authors.forename: Massimo
authors.initials: M
authors.lastname: De Felici
authors.forename: Florencia
authors.initials: F
authors.lastname: Barrios
mesh_terms: D000818:Animals; D019070:Cell Lineage; D005260:Female; D005854:Germ Cells / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000502:physiology*; D010053:Ovary / Q000166:cytology* / Q000502:physiology