title: [Influence of plant extracts on the activity of cholera toxin of Vibrio cholerae].
abstract: OBJECTIVE
  Study the activity of plant extracts against cholera toxin (CT) of Vibrio cholerae O1.
  
  
  METHODS
  Antitoxic activity of plant extracts was determined by using enzyme immunoassay and CHO-K1 cell culture.
  
  
  RESULTS
  8 water extracts of plants were studied. Extracts of nut, tutsan, milfoil, basil do not have effect on CT activity in EIA or CHO-K1 cell culture. Celandine and rhubarb extracts do not reduce CT immunochemical activity but prevent elongation of CHO-K1 cells. Oak and hop extracts suppress binding in EIA of cholera toxin and GM1 receptors and insignificantly reduce its activity in cell culture.
  
  
  CONCLUSIONS
  Antitoxic activityofplant extracts against CT is perspective for the development of preparations possessing inhibition effect.
authors.forename: O V
authors.initials: OV
authors.lastname: Markina
authors.forename: L P
authors.initials: LP
authors.lastname: Alekseeva
authors.forename: N V
authors.initials: NV
authors.lastname: Markin
authors.forename: N R
authors.initials: NR
authors.lastname: Telesmanich
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D016466:CHO Cells; D002772:Cholera Toxin / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006224:Cricetinae; D003412:Cricetulus; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D014734:Vibrio cholerae
chemical_list: D000276:Adjuvants, Immunologic; D000975:Antioxidants; D010936:Plant Extracts; D002772:Cholera Toxin