title: Skeletal muscle fatigue.
abstract: Skeletal muscle fatigue is defined as the fall of force or power in response to contractile activity. Both the mechanisms of fatigue and the modes used to elicit it vary tremendously. Conceptual and technological advances allow the examination of fatigue from the level of the single molecule to the intact organism. Evaluation of muscle fatigue in a wide range of disease states builds on our understanding of basic function by revealing the sources of dysfunction in response to disease.
authors.affiliation: Department of Kinesiology, University of Massachusetts-Amherst, Amherst, Massachusetts, USA. janekb@kin.umass.edu
authors.forename: Jane A
authors.initials: JA
authors.lastname: Kent-Braun
authors.forename: Robert H
authors.initials: RH
authors.lastname: Fitts
authors.forename: Anita
authors.initials: A
authors.lastname: Christie
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D006801:Humans; D007103:Immobilization; D007473:Ion Channels / Q000502:physiology; D032342:Muscle Cells / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology*; D018482:Muscle, Skeletal / Q000098:blood supply / Q000294:innervation / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D012727:Sex Characteristics; D013119:Spinal Cord Injuries / Q000503:physiopathology
chemical_list: D007473:Ion Channels