title: Concise synthesis and antimalarial activity of all four mefloquine stereoisomers using a highly enantioselective catalytic borylative alkene isomerization.
authors.affiliation: Department of Chemistry, University of Alberta, Gunning-Lemieux Chemistry Centre, 4-010 Centennial Centre for Interdisciplinary Science, Edmonton, Alberta, T6G 2G2, Canada.
authors.forename: Jinyue
authors.initials: J
authors.lastname: Ding
authors.forename: Dennis G
authors.initials: DG
authors.lastname: Hall
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D006865:Hydrogenation; D015767:Mefloquine / Q000737:chemistry*; D010961:Plasmodium / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000475:Alkenes; D000962:Antimalarials; D015767:Mefloquine
keywords: allylboration; asymmetric catalysis; malaria; mefloquines; total synthesis