title: Variability of glycemic and insulin response to a standard meal, within and between healthy subjects.
abstract: OBJECTIVE
  To test the variability within and between subject of glycemic response test following the ingestion of a standard food.
  
  
  METHODS
  Glucose and insulin response of a standard meal (white bread) was performed in ten healthy volunteers and repeated under identical conditions for 6 times. Blood glucose and insulin levels were measured in the fasted state and over the 180 min following commencement of consumption of the foods The Area Under the Curve (AUC) for glucose and insulin was calculated for the values above baseline for the 3-hour period following the standard meal. Within and between coefficient of variation was calculated.
  
  
  RESULTS
  The total intra-individual variation of the gAUC was 51.8% range 24.9 to 91.4%. The inter-individual variation of the gAUC in the complete study was 75.2% . The total intra-individual variation of the iAUC was 51.9%. ranged: 7.7 to 103%. The inter-individual variation in the complete study was 86%.
  
  
  CONCLUSIONS
  Glucose and insulin response to a reference food has low reliability, therefore limits its clinical utility for individual dietary prescription.
authors.affiliation: Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. shirsch@inta.uchile.cl
authors.forename: Sandra
authors.initials: S
authors.lastname: Hirsch
authors.forename: Gladys
authors.initials: G
authors.lastname: Barrera
authors.forename: Laura
authors.initials: L
authors.lastname: Leiva
authors.forename: María Pía
authors.initials: MP
authors.lastname: de la Maza
authors.forename: Daniel
authors.initials: D
authors.lastname: Bunout
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D001939:Bread; D005215:Fasting / Q000378:metabolism; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin