title: Serum levels of angiopoietin-2, but not angiopoietin-1, are elevated in patients with erythrodermic cutaneous T-cell lymphoma.
abstract: Angiogenesis is a crucial process in the growth and progression of cancer, correlating with the metastatic potential of tumour cells. Angiopoietins are ligands for the endothelium-specific tyrosine kinase Tie2 receptor, which comprise 4 structurally related proteins, termed angiopoietin (Ang)-1, Ang-2, Ang-3 and Ang-4. The roles of Ang-1 and Ang-2 have recently been clarified as crucial in angiogenesis. In this report, we measured serum Ang-1 and Ang-2 levels in patients with cutaneous T-cell lymphoma (CTCL). Serum levels of Ang-2, but not Ang-1, in patients with Sézary syndrome were significantly higher than those in patch mycosis fungoides (MF), plaque/tumour MF, and healthy controls. In patients with CTCL, serum Ang-2 correlated with disease activity. Moreover, the numbers of Ang-2+ cells in lesional skin of CTCL were significantly larger than those in normal skin. These results suggest that Ang-2 may have important roles in the development of CTCL.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugaya
authors.forename: Hiraku
authors.initials: H
authors.lastname: Suga
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Miyagaki
authors.forename: Hanako
authors.initials: H
authors.lastname: Ohmatsu
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujita
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Tada
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kadono
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000328:Adult; D000368:Aged; D042683:Angiopoietin-1 / Q000032:analysis / Q000097:blood*; D042702:Angiopoietin-2 / Q000032:analysis / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D019742:Chemokines, CC / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000097:blood* / Q000737:chemistry / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000097:blood; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000097:blood; D012751:Sezary Syndrome / Q000097:blood* / Q000737:chemistry / Q000473:pathology; D012867:Skin / Q000098:blood supply / Q000737:chemistry; D012878:Skin Neoplasms / Q000097:blood* / Q000098:blood supply / Q000737:chemistry / Q000473:pathology
chemical_list: D042683:Angiopoietin-1; D042702:Angiopoietin-2; D014408:Biomarkers, Tumor; D019742:Chemokines, CC; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D015375:Receptors, Interleukin-2; D007073:Immunoglobulin E; D007770:L-Lactate Dehydrogenase