title: Hyperferritinemia in dogs with splenic hemangiosarcoma.
abstract: Serum ferritin concentration increases in dogs in association with various diseases. In this study, we measured serum ferritin levels in dogs with splenic masses, using a sandwich ELISA assay. Eleven dogs with hemangiosarcoma (HSA), six with hematoma, 1 with hemangioma and 3 with lymphoma were enrolled. All dogs with HSA had serum ferritin concentrations above the normal limit (1,357 ng/ml, mean + 2× standard deviation of normal). Increased serum ferritin concentrations have also been observed in few cases of hematoma, hemangioma and lymphoma. Therefore, hyperferritinemia is not specific for splenic HSA, but may have clinical usefulness as a sensitive test for the disease. Further evaluation of serum ferritin concentrations in dogs with splenic HSA is needed.
authors.affiliation: Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan.
authors.forename: Seishiro
authors.initials: S
authors.lastname: Chikazawa
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Hori
authors.forename: Fumio
authors.initials: F
authors.lastname: Hoshi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kanai
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Ito
authors.forename: Seiichi
authors.initials: S
authors.lastname: Higuchi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000473:pathology*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D005293:Ferritins / Q000097:blood*; D006394:Hemangiosarcoma / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D008297:Male; D013160:Splenic Neoplasms / Q000097:blood / Q000473:pathology / Q000662:veterinary*
chemical_list: D015415:Biomarkers; D005293:Ferritins