title: Royal sun medicinal mushroom, Agaricus brasiliensis Ka21 (higher Basidiomycetes), as a functional food in humans.
abstract: The Royal Sun medicinal mushroom, Agaricus brasiliensis, is used as a natural health product. In Japan, however, the quality control of some of these mushroom products has been viewed as a safety problem. Focusing on the quality control of A. brasiliensis KA21, we have performed several safety studies. To date, we have established evidence that this mushroom can be used safely as an immunostimulant and to mediate biochemical parameters associated with obesity or diabetes. Furthermore, to improve the manufacturing process of this mushroom, we have studied the relationship between its pharmaceutical actions and the conditions of its cultivation and thermal management. The purpose of this review is to report the findings of basic and clinical studies of the fruit body of A. brasiliensis KA21.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Tokyo Japan. ohnonao@toyaku.ac.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamanaka
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Masuro
authors.initials: M
authors.lastname: Motoi
authors.forename: Naohito
authors.initials: N
authors.lastname: Ohno
mesh_terms: D000364:Agaricus / Q000737:chemistry*; D055951:Functional Food; D006801:Humans