title: Elevated Galectin-3 Levels in the Serum of Patients With Alzheimer's Disease.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system. Galectin-3 (Gal-3) is characterized by a conserved sequence within the carbohydrate recognition domain. The effect of Gal-3 in AD is presently unknown. In this study, we found significantly increased Gal-3 serum levels in patients with AD compared to control participants (P=.017). There was no significant difference between patients with mild cognitive impairment (MCI) and healthy controls (P=.143) or between patients with AD and MCI (P=.688). The degree of cognitive impairment, as measured by the Mini-Mental Status Examination score, was found to have a significant correlation with the Gal-3 serum levels in all patients and healthy controls. These data suggest that Gal-3 potentially plays a role in the neuropathogenesis of AD. The Gal-3 found in serum could be a potential candidate for a biomarker panel for AD diagnosis.
authors.affiliation: Department of Rehabilitation Medicine, Qilu Hospital of Shandong University, Ji'nan, Shandong, People's Republic of China Department of Rehabilitation Medicine, Yuhuangding Hospital, Yantai, Shandong, People's Republic of China.
authors.forename: Xuexin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, Yantai Hospital for Infectious Diseases, Yantai, Shandong, People's Republic of China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Rehabilitation Medicine, Yuhuangding Hospital, Yantai, Shandong, People's Republic of China.
authors.forename: Faliang
authors.initials: F
authors.lastname: Lin
authors.affiliation: Department of Neurology, Yuhuangding Hospital, Yantai, Shandong, People's Republic of China.
authors.forename: Wenzheng
authors.initials: W
authors.lastname: Chu
authors.affiliation: Department of Rehabilitation Medicine, Qilu Hospital of Shandong University, Ji'nan, Shandong, People's Republic of China swyue6015@hotmail.com.
authors.forename: Shouwei
authors.initials: S
authors.lastname: Yue
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D060825:Cognitive Dysfunction / Q000097:blood*; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D037502:Galectin 3
keywords: Alzheimer’s disease; biomarker; galectin-3; serum; β-amyloid