title: Bioactive phenylpropanoid glycosides from Tabebuia avellanedae.
abstract: Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison with published data. All isolated compounds showed strong antioxidant activity in the DPPH assay, and compound 5 give the highest antioxidant activity among all compounds, with an IC₅₀ of 0.12 µM. All compounds exhibited moderate inhibitory effect on cytochrome CYP3A4 enzyme.
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. suomaorong@163.com
authors.forename: Maorong
authors.initials: M
authors.lastname: Suo
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
authors.forename: Fumihide
authors.initials: F
authors.lastname: Takano
authors.forename: Shouwen
authors.initials: S
authors.lastname: Jin
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D065692:Cytochrome P-450 CYP3A Inhibitors; D016166:Free Radical Scavengers / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D020005:Propanols / Q000737:chemistry / Q000302:isolation & purification; D029663:Tabebuia / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D065692:Cytochrome P-450 CYP3A Inhibitors; D016166:Free Radical Scavengers; D006027:Glycosides; D010936:Plant Extracts; D020005:Propanols