title: [Research progress on pathologic complete response after neoadjuvant chemoradiotherapy for locally advanced rectal cancer].
abstract: Neoadjuvant chemoradiotherapy followed by surgery is the standard treatment for patients with locally advanced rectal cancer. Controversy on whether patients should receive radical surgery after pathological complete response (pCR) after neoadjuvant chemoradiotherapy has remained since pCR patients have shown favorable long-term outcome. Progress in multidisciplinary modalities has been made, including MRI, PET/CT imaging studies, genetic expression profiling, etc. The methods of predicting pCR response are inspiring. In this article, we review the methods for prediction and prognostic effect of pCR response when patients with locally advanced rectal cancer are treated with neoadjuvant chemoradiotherapy.
authors.affiliation: Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. wenbix@mail.sysu.edu.cn.
authors.forename: Hai-hua
authors.initials: HH
authors.lastname: Peng
authors.forename: Kai-yun
authors.initials: KY
authors.lastname: You
authors.forename: Yuan-hong
authors.initials: YH
authors.lastname: Gao
authors.forename: Bi-xiu
authors.initials: BX
authors.lastname: Wen
mesh_terms: D059248:Chemoradiotherapy; D006801:Humans; D020360:Neoadjuvant Therapy; D012004:Rectal Neoplasms / Q000628:therapy*; D012074:Remission Induction; D016896:Treatment Outcome