title: Synthesis, antimicrobial and cytotoxic activities of sulfonamidomethane linked heterocycles.
abstract: A new class of sulfonamidomethane pyrrolyl-oxadiazoles/thiadiazoles and pyrazolyl-oxadiazoles/thiadiazoles was prepared from arylsulfonylaminoacetic acid hydrazides and E-cinnamic acid. The lead compounds were tested for antimicrobial and cytotoxic activities. The thiadiazole compounds having chloro substituent on the aromatic ring 4c, 8c and 10c exhibited comparable antibacterial activity against Pseudomonas aeruginosa and also antifungal activity against Penicillium chrysogenum. The styryl oxadiazole compound 3c showed appreciable cytotoxic activity on A549 lung carcinoma cells which can be used as a lead compound in the future studies.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati–517 502, Andhra Pradesh, India.
authors.forename: Mukkara
authors.initials: M
authors.lastname: Swapna
authors.forename: Chokkappagari
authors.initials: C
authors.lastname: Premakumari
authors.forename: Sanapalli Nagi
authors.initials: SN
authors.lastname: Reddy
authors.forename: Adivireddy
authors.initials: A
authors.lastname: Padmaja
authors.forename: Venkatapuram
authors.initials: V
authors.lastname: Padmavathi
authors.forename: Paturu
authors.initials: P
authors.lastname: Kondaiah
authors.forename: Narra Siva
authors.initials: NS
authors.lastname: Krishna
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D010408:Penicillium chrysogenum / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D013830:Thiadiazoles / Q000737:chemistry
chemical_list: C585889:2-(p-chlorophenylsulfonylaminomethyl)-5-styryl-1,3,4-oxadiazole; D000890:Anti-Infective Agents; D006571:Heterocyclic Compounds; D010069:Oxadiazoles; D013449:Sulfonamides; D013830:Thiadiazoles