title: Pure androgen-secreting adrenal adenoma associated with resistant hypertension.
abstract: Pure androgen-secreting adrenal adenoma is very rare, and its diagnosis remains a clinical challenge. Its association with resistant hypertension is uncommon and not well understood. We present an 18-year-old female with a 10-year history of hirsutism that was accidentally diagnosed with an adrenal mass during the evaluation of a hypertensive crisis. She had a long-standing history of hirsutism, clitorimegaly, deepening of the voice, and primary amenorrhea. She was phenotypically and socially a male. FSH, LH, prolactin, estradiol, 17-hydroxyprogesterone, and progesterone were normal. Total testosterone and DHEA-S were elevated. Cushing syndrome, primary aldosteronism, pheochromocytoma, and nonclassic congenital adrenal hyperplasia were ruled out. She underwent adrenalectomy and pathology reported an adenoma. At 2-month followup, hirsutism and virilizing symptoms clearly improved and blood pressure normalized without antihypertensive medications, current literature of this unusual illness and it association with hypertension is presented and discussed.
authors.affiliation: Endocrinology Division, University Hospital "Dr. José E. González," Universidad Autonoma de Nuevo León, 64460 Monterrey, NL, Mexico.
authors.forename: René
authors.initials: R
authors.lastname: Rodríguez-Gutiérrez
authors.forename: Mario Arturo
authors.initials: MA
authors.lastname: Bautista-Medina
authors.forename: Ana Eugenia
authors.initials: AE
authors.lastname: Teniente-Sanchez
authors.forename: Maria Azucena
authors.initials: MA
authors.lastname: Zapata-Rivera
authors.forename: Juan
authors.initials: J
authors.lastname: Montes-Villarreal