title: Impaired global and segmental myocardial deformation assessed by two-dimensional speckle tracking echocardiography in patients with vitamin B12 deficiency.
abstract: BACKGROUND
  Contrary effects of vitamin B12 deficiency have been shown on the cardiovascular system. Aim of our study was to analyze left ventricular (LV) myocardial deformation, by using the two dimensional (2D) speckle tracking echocardiography (STE) in patients with vitamin B12 deficiency and normal LV ejection fraction.
  
  
  METHODS
  Twenty-five patients with vitamin B12 deficiency (B12 levels < 200 pg/mL; mean age: 29.6 ± 8.2 years, 15 female), and 27 healthy controls (B12 levels > 200 pg/mL; mean age: 30.1 ± 6.9 years, 13 female) were included in the study. 2D echocardiography images were transferred to a workstation for further offline analysis. Longitudinal peak systolic (LPSS) and global strain (LGS) was obtained from 4 chamber and apical long axis (APLAX) views.
  
  
  RESULTS
  Standard echocardiographic parameters and tissue Doppler imaging (TDI) velocities were compared between the groups. All LPSS values in the patient group except for apical 4C septal wall longitudinal strain were significantly decreased than those in the control group. There was a positive correlation between B12 levels and strain values except apical 4C septal wall strain values.
  
  
  CONCLUSIONS
  We found that in patients with vitamin B12 deficiency, global and segmental myocardial deformation was impaired and this impairment was correlated with the levels of vitamin B12.
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Kaya
authors.affiliation: Department of Cardiology, Harran University School of Medicine, Turkey. asubicer@yahoo.com.
authors.forename: Asuman
authors.initials: A
authors.lastname: Bicer
authors.forename: Funda
authors.initials: F
authors.lastname: Yalcin
authors.forename: Arzu
authors.initials: A
authors.lastname: Er
authors.forename: Aysun
authors.initials: A
authors.lastname: Camuzcuoglu
authors.forename: Nurhan
authors.initials: N
authors.lastname: Korkmaz
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sezen
mesh_terms: D000328:Adult; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*; D014806:Vitamin B 12 Deficiency / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology