title: Analysis of progression and recurrence of meningioma using (11)C-methionine PET.
abstract: OBJECTIVE
  The recurrence rate of meningioma after surgery is high, and progression is often observed. The risk factors for recurrence and progression are not clear. We evaluated the risk factors for recurrence and progression in meningioma using (11)C-methionine (MET) positron emission tomography (PET).
  
  
  METHODS
  Thirty-seven patients (mean follow-up, 80 months) with an intracranial meningioma were enrolled. MET PET was performed before treatment between 1995 and 2010, and patients were followed up in an out-patient clinic. Surgery was performed in 33 patients, and a wait-and-see approach was taken in four patients. We evaluated the extent of tumor resection, location, WHO grade, Ki-67 labeling index, and lesion to normal ratio (LN ratio) of MET uptake.
  
  
  RESULTS
  Six of the surgical cases had a recurrence, and two of the observation-only patients had tumor progression. A high LN ratio of MET uptake was a significant risk factor for recurrence and progression with univariate analysis. The area under the curve of receiver operating characteristic curve for the LN ratio of MET uptake was 0.754, and the optimal cutoff value was 3.18 (sensitivity 63 %, specificity 79 %). With multivariate analysis, a high LN ratio of MET uptake, non-gross total resection, and a high WHO grade were significant risk factors for progression and recurrence.
  
  
  CONCLUSIONS
  A high LN ratio of MET uptake was a risk factor for tumor progression and recurrence. The advantage of MET PET is that it is not invasive and can easily be used to evaluate the whole tumor.
authors.affiliation: Department of Neurosurgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan, hide-i@med.osaka-cu.ac.jp.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Naohiro
authors.initials: N
authors.lastname: Tsuyuguchi
authors.forename: Noritsugu
authors.initials: N
authors.lastname: Kunihiro
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Takeo
authors.initials: T
authors.lastname: Goto
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohata
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging*; D008579:Meningioma / Q000000981:diagnostic imaging*; D008715:Methionine; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012372:ROC Curve; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: C086242:carbon-11 methionine; D008715:Methionine