title: [General anesthetic management of a patient with spinal muscular atrophy type III].
abstract: We report a 61-year-old woman (weight 49 kg, height 156 cm) with Kugelberg-Welander disease who was scheduled for bilateral mastectomy under general anesthesia. We administered rocuronium 10 mg (0.20 mg x kg(-1)) for tracheal intubation. After 80 min, train-of-four ratio (TOFR) was 46%. During the operation, we did not administer rocuronium. After surgery, TOFR was 62%. Therefore, we administered sugammadex 100 mg (2 mg x kg(-1)). After 4 min, TOFR became above 90%, and the patient was extubated. There was no respiratory distress, muscle weakness, or neurologic untoward event after the use of sugammadex in the postoperative period. Sugammadex was effective in reversing rocuronium induced neuromuscular block in a patient with Kugelberg-Welander disease.
authors.affiliation: Department of Anesthesiology, Yao Municipal Hospital, Yao 581-0069.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Inamori
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Imashuku
authors.forename: Shota
authors.initials: S
authors.lastname: Sonobe
authors.forename: Chikahiko
authors.initials: C
authors.lastname: Sukenaga
authors.forename: Koichi
authors.initials: K
authors.lastname: Yabuta
authors.forename: Toshiya
authors.initials: T
authors.lastname: Hashimura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kura
authors.forename: Hideki
authors.initials: H
authors.lastname: Otada
mesh_terms: D000732:Androstanols / Q000008:administration & dosage; D000768:Anesthesia, General / Q000379:methods*; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods; D008408:Mastectomy; D008875:Middle Aged; D061886:Neuromuscular Monitoring; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage; D000077123:Rocuronium; D014897:Spinal Muscular Atrophies of Childhood / Q000150:complications*; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium