title: Esophageal mucosal metastasis from adenocarcinoma of the distal stomach.
abstract: Dissemination of gastric cancer may usually occur by direct spread through the perigastric tissues to adjacent organ, lymphatic spread, and hematogenous spread. We report a rare case of gastric cancer with mucosal metastastic lesion on the upper esophagus that was diagnosed by endoscopy and endosonography. A biopsy of the esophageal mass was performed and the pathologic findings with immunohistochemical stain for Mucin-5AC are proved to be identical to that of gastric adenocarcinoma, suggesting metastasis from main lesion of the gastric cancer. The lesion could not be explained by lymphatic or hematogenous spread, and its metastasis mechanism is considered to be different from previous studies. We suggest that the gastroesophageal reflux of cancer cells could be one of the possible metastatic pathways for metastasis of esophagus from an adenocarcinoma of the stomach.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Pohang St. Mary's Hospital, Pohang 790-825, South Korea.
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Ki
authors.forename: Seok
authors.initials: S
authors.lastname: Jeong
authors.forename: In Suh
authors.initials: IS
authors.lastname: Park
authors.forename: Don Haeng
authors.initials: DH
authors.lastname: Lee
authors.forename: Jung Il
authors.initials: JI
authors.lastname: Lee
authors.forename: Kye Sook
authors.initials: KS
authors.lastname: Kwon
authors.forename: Hyung Gil
authors.initials: HG
authors.lastname: Kim
authors.forename: Yong Woon
authors.initials: YW
authors.lastname: Shin
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002945:Cisplatin / Q000008:administration & dosage; D018450:Disease Progression; D000077143:Docetaxel; D016145:Endoscopy, Digestive System; D019160:Endosonography; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000556:secondary*; D004947:Esophagus / Q000737:chemistry / Q000473:pathology*; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC / Q000032:analysis; D009092:Mucous Membrane / Q000473:pathology; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin
keywords: Esophagus; Neoplasm metastasis; Stomach cancer