title: Beneficial Effects of Omega-3 Fatty Acids on Low Density Lipoprotein Particle Size in Patients with Type 2 Diabetes Already under Statin Therapy.
abstract: Beyond statin therapy for reducing low density lipoprotein cholesterol (LDL-C), additional therapeutic strategies are required to achieve more optimal reduction in cardiovascular risk among diabetic patients with dyslipidemia. To evaluate the effects and the safety of combined treatment with omega-3 fatty acids and statin in dyslipidemic patients with type 2 diabetes, we conducted a randomized, open-label study in Korea. Patients with persistent hypertriglyceridemia (≥200 mg/dL) while taking statin for at least 6 weeks were eligible. Fifty-one patients were randomized to receive either omega-3 fatty acid 4, 2 g, or no drug for 8 weeks while continuing statin therapy. After 8 weeks of treatment, the mean percentage change of low density lipoprotein (LDL) particle size and triglyceride (TG) level was greater in patients who were prescribed 4 g of omega-3 fatty acid with statin than in patients receiving statin monotherapy (2.8%±3.1% vs. 2.3%±3.6%, P=0.024; -41.0%±24.1% vs. -24.2%±31.9%, P=0.049). Coadministration of omega-3 fatty acids with statin increased LDL particle size and decreased TG level in dyslipidemic patients with type 2 diabetes. The therapy was well tolerated without significant adverse effects.
authors.affiliation: Department of Endocrinology, Gwangmyeong Sung Ae Hospital, Gwangmyeong, Korea.
authors.forename: Myung Won
authors.initials: MW
authors.lastname: Lee
authors.forename: Jeong Kyung
authors.initials: JK
authors.lastname: Park
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Hong
authors.forename: Kwang Joon
authors.initials: KJ
authors.lastname: Kim
authors.forename: Dong Yeob
authors.initials: DY
authors.lastname: Shin
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Young Duk
authors.initials: YD
authors.lastname: Song
authors.forename: Hong Keun
authors.initials: HK
authors.lastname: Cho
authors.forename: Seok Won
authors.initials: SW
authors.lastname: Park
authors.forename: Eun Jig
authors.initials: EJ
authors.lastname: Lee
keywords: Diabetes mellitus, type 2; Dyslipidemia; Fatty acids, omega-3; Hypertriglyceridemia; Low density lipoprotein particle