title: A category approach to predicting the developmental (neuro) toxicity of organotin compounds: the value of the zebrafish (Danio rerio) embryotoxicity test (ZET).
abstract: Zebrafish embryos were exposed to different organotin compounds during very early development (<100h post fertilization). Morphology, histopathology and swimming activity (in a motor activity test) were the endpoints analyzed. DBTC was, by far, the most embryotoxic compound at all time points and endpoints studied. In fact, we observed a clear concordance between the effects observed in our zebrafish embryo model, and those observed with these compounds in full rodent in vivo studies. All organotin compounds classified as developmental (neuro) toxicants in vivo, were correctly classified in the present assay. Together, our results support the ZET model as a valuable tool for providing biological verification for a grouping and a read-across approach to developmental (neuro) toxicity.
authors.affiliation: TNO, Research Group Risk Analysis for Products In Development, Zeist, The Netherlands. anna.beker@tno.nl
authors.forename: Anna
authors.initials: A
authors.lastname: Beker van Woudenberg
authors.forename: André
authors.initials: A
authors.lastname: Wolterbeek
authors.forename: Lindsey
authors.initials: L
authors.lastname: Te Brake
authors.forename: Cor
authors.initials: C
authors.lastname: Snel
authors.forename: Aswin
authors.initials: A
authors.lastname: Menke
authors.forename: Carina
authors.initials: C
authors.lastname: Rubingh
authors.forename: Didima
authors.initials: D
authors.lastname: de Groot
authors.forename: Dinant
authors.initials: D
authors.lastname: Kroese
mesh_terms: D000818:Animals; D004625:Embryo, Nonmammalian / Q000002:abnormalities / Q000187:drug effects* / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects; D009947:Organotin Compounds / Q000633:toxicity*; D013216:Reflex, Startle / Q000187:drug effects; D013623:Tail / Q000002:abnormalities; D013723:Teratogens / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods; D015027:Zebrafish
chemical_list: D009947:Organotin Compounds; D013723:Teratogens
keywords: Alternative model; Biological verification; Developmental (neuro) toxicity; Grouping; Organotins; Read across; Zebrafish embryotoxicity test (ZET)