title: The relationship between training status, blood pressure and uric acid in adults and elderly.
abstract: BACKGROUND
  Hypertension can be generated by a great number of mechanisms including elevated uric acid (UA) that contribute to the anion superoxide production. However, physical exercise is recommended to prevent and/or control high blood pressure (BP). The purpose of this study was to investigate the relationship between BP and UA and whether this relationship may be mediated by the functional fitness index.
  
  
  METHODS
  All participants (n = 123) performed the following tests: indirect maximal oxygen uptake (VO2max), AAHPERD Functional Fitness Battery Test to determine the general fitness functional index (GFFI), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and blood sample collection to evaluate the total-cholesterol (CHOL), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c), triglycerides (TG), uric acid (UA), nitrite (NO2) and thiobarbituric acid reactive substances (T-BARS). After the physical, hemodynamic and metabolic evaluations, all participants were allocated into three groups according to their GFFI: G1 (regular), G2 (good) and G3 (very good).
  
  
  RESULTS
  Baseline blood pressure was higher in G1 when compared to G3 (+12% and +11%, for SBP and DBP, respectively, p<0.05) and the subjects who had higher values of BP also presented higher values of UA. Although UA was not different among GFFI groups, it presented a significant correlation with GFFI and VO2max. Also, nitrite concentration was elevated in G3 compared to G1 (140±29 μM vs 111±29 μM, for G3 and G1, respectively, p<0.0001). As far as the lipid profile, participants in G3 presented better values of CHOL and TG when compared to those in G1.
  
  
  CONCLUSIONS
  Taking together the findings that subjects with higher BP had elevated values of UA and lower values of nitrite, it can be suggested that the relationship between blood pressure and the oxidative stress produced by uric acid may be mediated by training status.
authors.affiliation: Faculty of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Atila Alexandre
authors.initials: AA
authors.lastname: Trapé
authors.forename: André Mourão
authors.initials: AM
authors.lastname: Jacomini
authors.forename: Jaqueline Jóice
authors.initials: JJ
authors.lastname: Muniz
authors.forename: Jonas Tadeu Cau
authors.initials: JT
authors.lastname: Sertorio
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Tanus-Santos
authors.forename: Sandra Lia
authors.initials: SL
authors.lastname: do Amaral
authors.forename: Anderson Saranz
authors.initials: AS
authors.lastname: Zago
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid