title: Epimeric methylsulfinyladenosine derivatives from the marine ascidian Herdmania momus.
abstract: Investigation of the secondary metabolites of the ascidian Herdmania momus led to the isolation and characterization of four new nucleoside derivatives (1-4). Structural studies showed that these derivatives represent a series of rare methylsulfinyladenosine derivatives of interconvertible transesterification isomers and/or sulfinyl epimers. The antiviral activities of these rare nucleosides were evaluated against a series of human pathogenic viruses.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, South Korea.
authors.forename: Jian Lin
authors.initials: JL
authors.lastname: Li
authors.forename: Eun La
authors.initials: EL
authors.lastname: Kim
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Sook
authors.initials: S
authors.lastname: Shin
authors.forename: Chong-Kyo
authors.initials: CK
authors.lastname: Lee
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000241:Adenosine / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D014561:Urochordata / Q000737:chemistry*; D014780:Viruses / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D000241:Adenosine
keywords: Ascidian; Herdmania momus; Nucleoside derivatives; Sulfinyl epimers