title: Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease.
abstract: We tested the hypothesis that extracellular haem is linked to the incidence of acute complications of sickle cell disease (SCD). Using multivariable regression analysis, higher plasma free haem, but not total plasma haem, was associated with increased odds of vaso-occlusive crisis (VOC) [P = 0·028, odds ratio (OR); 2·05, 95% Confidence Interval (CI) = 1·08-3·89] and acute chest syndrome (ACS) [P = 0·016, OR; 2·56, CI = 1·19, 5·47], after adjusting for age and gender in children with SCD. These findings suggest that haem and factors that influence its concentration in plasma may be informative of the risk of VOC and ACS in SCD patients.
authors.affiliation: Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
authors.forename: Olufolake A
authors.initials: OA
authors.lastname: Adisa
authors.forename: Yijuan
authors.initials: Y
authors.lastname: Hu
authors.forename: Samit
authors.initials: S
authors.lastname: Ghosh
authors.forename: Doreen
authors.initials: D
authors.lastname: Aryee
authors.forename: Ifeyinwa
authors.initials: I
authors.lastname: Osunkwo
authors.forename: Solomon F
authors.initials: SF
authors.lastname: Ofori-Acquah
mesh_terms: D056586:Acute Chest Syndrome / Q000097:blood / Q000209:etiology*; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications*; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006418:Heme / Q000032:analysis*; D006801:Humans; D008297:Male
chemical_list: D015415:Biomarkers; D006418:Heme
keywords: acute chest syndrome; extracellular haem; sickle cell disease; vaso-occlusive pain crisis