title: Exploring the value of plasma BIN1 as a potential biomarker for alzheimer's disease.
abstract: BIN1, as an important genetic susceptibility locus in late-onset Alzheimer's disease (AD), is overexpressed in AD brains. Our study investigated BIN1 diagnostic value by quantifying its transcription level and plasma expression from 112 AD and 200 control subjects. We observed significant increase in BIN1 mRNA and protein levels in AD patients. Receiver operating characteristic curve analysis shown the sensitivity and specificity were 73% and 75% for plasma BIN1 in identifying AD. Although this is a pilot study requiring corroboration on a larger cohort of patients, our results highlight the possible use of plasma BIN1 as a biomarker for AD diagnosis.
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.forename: Meng-Shan
authors.initials: MS
authors.lastname: Tan
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008609:Mental Status Schedule; D009687:Nuclear Proteins / Q000097:blood*; D012372:ROC Curve; D025521:Tumor Suppressor Proteins / Q000097:blood*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C101410:BIN1 protein, human; D015415:Biomarkers; D009687:Nuclear Proteins; D025521:Tumor Suppressor Proteins