title: Microencapsulation of chemotherapeutics into monodisperse and tunable biodegradable polymers via electrified liquid jets: control of size, shape, and drug release.
abstract: This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods.
authors.affiliation: Departments of Bioengineering and Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Pouria
authors.initials: P
authors.lastname: Fattahi
authors.forename: Ali
authors.initials: A
authors.lastname: Borhan
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Abidian
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D002330:Carmustine / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism; D044085:Microfluidics; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002330:Carmustine
keywords: biomaterials; brain tumor; drug delivery; electrojetting; mathematical modeling; microcapsules