title: NLRP6 in infection and inflammation.
abstract: NLRs play fundamental roles in host-defense and inflammatory disorders. NLRP6 is a newly characterized member of this family that inhibits NF-κB and MAP-kinase dependent immune signaling to hamper anti-microbial defense. Further, NLRP6 regulates intestinal inflammation by maintaining gut microbiota composition. In this review, we examine the recent studies and emphasize the key functions regulated by NLRP6.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Paras K
authors.initials: PK
authors.lastname: Anand
authors.forename: Thirumala-Devi
authors.initials: TD
authors.lastname: Kanneganti
mesh_terms: D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D064307:Microbiota / Q000276:immunology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; C468563:NLRP6 protein, human
keywords: Infection; Innate immunity; Intestinal homeostasis; Microbiota; NLR; NLRP6