title: A case of acute reversible pure adrenergic failure.
abstract: A 14-year-old man presented 2 weeks after a viral pharyngitis with acute onset orthostasis and a pattern of pure adrenergic failure with neurogenic orthostatic hypotension that responded to intravenous immunoglobulin. The patient returned to his normal daily activities with resolution of his orthostatic hypotension and return of cardiac adrenergic responses as demonstrated by the Valsalva maneuver. Here we discuss the clinical and laboratory features of pure adrenergic failure, the more common etiologies, and the potential treatment options, with a focus on those presentations presumed to be autoimmune or inflammatory.
authors.affiliation: Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Department of Clinical Neurological Sciences, University Hospital, London Health Sciences Centre, London, Ontario, Canada. Electronic address: kkimpin@uwo.ca.
authors.forename: Kurt
authors.initials: K
authors.lastname: Kimpinski
authors.forename: Colleen T
authors.initials: CT
authors.lastname: Ives
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D010612:Pharyngitis / Q000150:complications
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: Autonomic neuropathy; Intravenous immunoglobulin; Pure adrenergic failure