title: Microradiography and microcomputed tomography comparative analysis in human bone cores harvested after maxillary sinus augmentation: a pilot study.
abstract: OBJECTIVE
  The aim of this study was to compare microradiography (MR) and microcomputed tomography (μCT) analysis of bone samples following maxillary sinus augmentation at different time periods and determine the relationships between measured area and volume fractions.
  
  
  METHODS
  Lateral window sinus grafts were performed on 10 patients using a mineralized human bone allograft (MHBA). At implant placement, 5-13 months after surgery, 10 bone core biopsies were harvested. Prior to histologic sectioning, bone samples were evaluated with μCT. The morphometric parameters computed by MR and μCT were compared using Pearson's correlation and Bland and Altman analysis and included hard tissue fraction (HV/TV:%), soft tissue fraction (SV/TV:%), vital bone fraction (BV/TV:%) and residual graft fraction (GV/TV:%).
  
  
  RESULTS
  Strong positive correlation between MR and μCT was found for HV/TV and SV/TV and BV/TV [r = 0.84, 0.84 and 0.69, respectively] but weak for GV/TV [r = 0.10].
  
  
  CONCLUSIONS
  μCT technology shows promising potential as an indicator of bone morphology changes; however, caution should be used in interpreting morphometric parameters, as the different methods reveal important biases.
authors.affiliation: Private Practice, Brescia, Italy.
authors.forename: Carlo Maria
authors.initials: CM
authors.lastname: Soardi
authors.forename: Emanuele
authors.initials: E
authors.lastname: Clozza
authors.forename: Gianluca
authors.initials: G
authors.lastname: Turco
authors.forename: Matteo
authors.initials: M
authors.lastname: Biasotto
authors.forename: Steven P
authors.initials: SP
authors.lastname: Engebretson
authors.forename: Hom-Lay
authors.initials: HL
authors.lastname: Wang
authors.forename: Davide
authors.initials: D
authors.lastname: Zaffe
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007558:Italy; D008297:Male; D008443:Maxillary Sinus / Q000000981:diagnostic imaging* / Q000601:surgery; D008852:Microradiography; D008875:Middle Aged; D011862:Radiography, Panoramic; D059546:Sinus Floor Augmentation; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055114:X-Ray Microtomography
keywords: bone formation; bone graft; bone histomorphometry; microcomputed tomography; microradiography