title: Vascular endothelial growth factor in children with thalassemia major.
abstract: BACKGROUND
  The β-Thalassemia syndromes are the most common hereditary chronic hemolytic anemia due to impaired globin chain synthesis. Vascular endothelial growth factor (VEGF) plays several roles in angiogenesis which is a crucial process in the pathogenesis of several inflammatory, autoimmune and malignant diseases. Endothelial damage and inflammation make a significant contribution to the pathophysiology of β-thalassemia.
  
  
  OBJECTIVE
  : The aim of the study was to assess serum VEGF level in children with beta-thalassemia major as a marker of angiogenesis.
  
  
  METHODS
  A total of 50 children entered the study, 40 patients with thalassemia major and 10 healthy controls. We used enzyme-linked immunosorbent assay for quantitative evaluation of VEGF.
  
  
  RESULTS
  VEGF level was significantly higher in patients with β-thalassemia major than healthy controls (p=0.001). VEGF level was also higher in splenectomised thalassemic patients than non splenectomised ones (p=0.001). There were a positive correlation between VEGF and chelation starting age (p=0.008), and a negative correlation between VEGF and frequency of blood transfusion (p=0.002).
  
  
  CONCLUSIONS
  Thalassemia patients, especially splenectomized, have elevated serum levels of VEGF. Early chelation and regular blood transfusion help to decrease serum VEGF and the risk of angiogenesis.
authors.affiliation: Pediatrics Department, Beni Suef University.
authors.forename: Sameh S
authors.initials: SS
authors.lastname: Fahmey
authors.forename: Hassan F
authors.initials: HF
authors.lastname: Naguib
authors.forename: Sanna S
authors.initials: SS
authors.lastname: Abdelshafy
authors.forename: Rasha E
authors.initials: RE
authors.lastname: Alashry