title: Establishment and evaluation of a swine model of acute myocardial infarction and reperfusion-ventricular fibrillation-cardiac arrest using the interventional technique.
abstract: BACKGROUND
  Ventricular fibrillation is the main cause of sudden cardiac death among patients with acute myocardial infarction (AMI). Substantial benefits could be obtained by both researchers and practitioners if an AMI reperfusion-ventricular fibrillation-cardiac arrest model were established.
  
  
  METHODS
  Twenty swine were anesthetized and underwent occlusion of the left anterior descending branch for 90 minutes prior to blood reperfusion. Throughout this process, continuous 12-lead electrocardiography (ECG) was used to monitor heart rate, rhythm, and electrocardiogram alteration. Thereafter, AMI was confirmed by ECG and left ventricular angiography. Heart tissue was collected for pathological analysis, and for evaluation of the establishment of a model of AMI reperfusion.
  
  
  RESULTS
  Seven swine died during the model establishment, and the 13 surviving swine were proven to have myocardial infarction; nine of those survivors had ventricular fibrillation-cardiac arrest after reperfusion based on the electrocardiograph and pathological examination.
  
  
  CONCLUSIONS
  Blocking the left anterior descending branch by inflation of an over-the-wire coronary balloon catheter in swine can result in successful establishment of a swine model of AMI and reperfusion-ventricular fibrillation-cardiac arrest, with good reproducibility and a high survival rate.
authors.affiliation: Emergency Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Dan-Bing
authors.initials: DB
authors.lastname: Shao
authors.forename: Feng-Xiang
authors.initials: FX
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Man
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.forename: Bang-Xia
authors.initials: BX
authors.lastname: Liu
authors.forename: Dao-Wu
authors.initials: DW
authors.lastname: Wang
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Li
authors.forename: Ke-Jiang
authors.initials: KJ
authors.lastname: Cao
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006323:Heart Arrest / Q000503:physiopathology; D009203:Myocardial Infarction / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology; D013552:Swine; D014693:Ventricular Fibrillation / Q000503:physiopathology
keywords: cardiac arrest; coronary interventional technique; myocardial infarction; swine model; ventricular fibrillation