title: Interstitial leukocyte migration in vivo.
abstract: Rapid leukocyte motility is essential for immunity and host defense. There has been progress in understanding the molecular signals that regulate leukocyte motility both in vitro and in vivo. However, a gap remains in understanding how complex signals are prioritized to result in directed migration, which is critical for both adaptive and innate immune function. Here we focus on interstitial migration and how external cues are translated into intracellular signaling pathways that regulate leukocyte polarity, directional sensing and motility in three-dimensional spaces.
authors.affiliation: Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: Pui-ying
authors.initials: PY
authors.lastname: Lam
authors.forename: Anna
authors.initials: A
authors.lastname: Huttenlocher
mesh_terms: D000818:Animals; D002465:Cell Movement; D006434:Hemocytes / Q000166:cytology / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000276:immunology*; D015398:Signal Transduction