title: Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis.
abstract: Soon after Sry initiates male sex determination, cells in XY gonads undergo an unusual process of de novo cord formation that results in the organization of Sertoli cells into epithelial tubules enclosing germ cells and partitioning mesenchymal cells and vasculature to the interstitial space of the testis. Recent experiments investigating this dynamic process in four dimensions have begun to shed new light on the collective interactions of multiple cell types during morphogenesis of testis cords.
authors.affiliation: Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Jonah
authors.initials: J
authors.lastname: Cool
authors.forename: Tony
authors.initials: T
authors.lastname: DeFalco
authors.forename: Blanche
authors.initials: B
authors.lastname: Capel
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000502:physiology; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D005109:Extracellular Matrix / Q000235:genetics / Q000378:metabolism; D005854:Germ Cells / Q000502:physiology; D006066:Gonads / Q000254:growth & development / Q000378:metabolism; D007985:Leydig Cells / Q000166:cytology / Q000502:physiology; D008297:Male; D051379:Mice; D012708:Sertoli Cells / Q000502:physiology; D013737:Testis / Q000254:growth & development* / Q000502:physiology