title: Neuroretinitis: a rare feature of tubulointerstitial nephritis and uveitis syndrome.
abstract: A 17-year-old female presented to our hospital with fatigue, arthralgia and fever associated with non-granulomatous anterior uveitis in the left eye. Blood tests revealed renal failure and a renal biopsy showed acute tubulointerstitial nephritis. Findings were consistent with tubulointerstitial nephritis and uveitis (TINU) syndrome. The patient received systemic corticosteroids for 2 months as well as dexamethasone and mydriatic drops. Bilateral non-granulomatous anterior uveitis occurred 10 days after prednisone discontinuation, and was treated with topical steroids; however, uveitis recurred several weeks later. Bilateral anterior chamber inflammation was associated with neuroretinitis in the right eye. Extensive posterior synechiae precluded fundus examination of the left eye. The posterior segment manifestations responded to systemic prednisone, which was slowly tapered. The final visual outcome was favorable. TINU syndrome may rarely manifest with neuroretinitis.
authors.affiliation: Department of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
authors.forename: Sana
authors.initials: S
authors.lastname: Khochtali
authors.forename: Olfa
authors.initials: O
authors.lastname: Harzallah
authors.forename: Rym
authors.initials: R
authors.lastname: Hadhri
authors.forename: Cyrine
authors.initials: C
authors.lastname: Hamdi
authors.forename: Sonia
authors.initials: S
authors.lastname: Zaouali
authors.forename: Moncef
authors.initials: M
authors.lastname: Khairallah
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000150:complications*; D012173:Retinitis / Q000209:etiology*; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications*
chemical_list: D000893:Anti-Inflammatory Agents