title: Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT3A and 5-HT6 receptor subtypes.
abstract: Cortical circuits control higher-order cognitive processes and their function is highly dependent on their structure that emerges during development. The construction of cortical circuits involves the coordinated interplay between different types of cellular processes such as proliferation, migration, and differentiation of neural and glial cell subtypes. Among the multiple factors that regulate the assembly of cortical circuits, 5-HT is an important developmental signal that impacts on a broad diversity of cellular processes. 5-HT is detected at the onset of embryonic telencephalic formation and a variety of serotonergic receptors are dynamically expressed in the embryonic developing cortex in a region and cell-type specific manner. Among these receptors, the ionotropic 5-HT3A receptor and the metabotropic 5-HT6 receptor have recently been identified as novel serotonergic targets regulating different aspects of cortical construction including neuronal migration and dendritic differentiation. In this review, we focus on the developmental impact of serotonergic systems on the construction of cortical circuits and discuss their potential role in programming risk for human psychiatric disorders.
authors.affiliation: Laboratoire de Neurobiologie, ESPCI ParisTech, Centre National de la Recherche Scientifique-UMR 7637 Paris, France.
authors.forename: Tania
authors.initials: T
authors.lastname: Vitalis
authors.forename: Mark S
authors.initials: MS
authors.lastname: Ansorge
authors.forename: Alexandre G
authors.initials: AG
authors.lastname: Dayer
keywords: 5-HT; 5-HT3 receptor; 5-HT6 receptor; cerebral cortex; circuit assembly; development; plasticity; somatosensory cortex