title: [Antioxidant agents in neuroprotection treatment of glaucoma].
abstract: Purpose was to study efficiency and safety of mexidol in combined therapy in patients with primary open-angle glaucoma (POAG). 94 patients (185 eyes) at the age of 18-75 years old with POAG I-III stages were divided into 3 groups: 50 patients received combined therapy of mexidol 100 mg and picamilon 150 mg, 22 patients received combined therapy of mexidol 300 mg and picamilon 150 mg, 22 patients received only picamilon 150 mg. All medicine was administered qd during 14 or 21 days. Examination included standard ophthalmologic methods, perimetry, electroretinography, retinal and optic nerve heard arterial blood flow. Improvement of visual acuity, perimetric, electrofisiological indicies and increased blood flow velocity of central retinal artery were registrated. Combined mexidol therapy allows improving results in treatment of patients with POAG.
authors.forename: E A
authors.initials: EA
authors.lastname: Egorov
authors.forename: A A
authors.initials: AA
authors.lastname: Gvetadze
authors.forename: N G
authors.initials: NG
authors.lastname: Davydova
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics; D001682:Biological Availability; D001783:Blood Flow Velocity / Q000187:drug effects*; D003941:Diagnostic Techniques, Ophthalmological; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D009898:Optic Disk / Q000098:blood supply / Q000187:drug effects; D010847:Picolines / Q000008:administration & dosage / Q000493:pharmacokinetics; D012039:Regional Blood Flow / Q000187:drug effects*; D012161:Retinal Artery / Q000503:physiopathology; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D010847:Picolines; C070020:emoxypine succinate; C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid