title: Development of predictive models for estimating warfarin maintenance dose based on genetic and clinical factors.
abstract: In this chapter, we use calculation of estimated warfarin maintenance dosage as an example to illustrate how to develop a multiple linear regression model to quantify the relationship between several independent variables (e.g., patients' genotype information) and a dependent variable (e.g., measureable clinical outcome).
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Mark W
authors.initials: MW
authors.lastname: Linder
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005838:Genotype; D006801:Humans; D019934:International Normalized Ratio; D016014:Linear Models; D008962:Models, Theoretical; D015999:Multivariate Analysis; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D014859:Warfarin