title: Near full-length genome identification of a novel HIV type 1 B'/C recombinant isolate JL100091 in Jilin, China.
abstract: We report here a novel HIV-1 B'/C recombinant isolate JL100091, identified from an HIV-positive female subject infected through heterosexual transmission in Jilin in 2006. The near full-length genome analyses of the novel recombinant (JL10091) showed that one subtype B' region (3,085 bp) was inserted into the subtype C backbone, with two breakpoints observed in gag and pol genes. To our knowledge, this is the first detection of a novel HIV-1 B'/C recombinant in Jilin, which indicates ongoing transmission of networks among the heterosexual population in the region. The novel HIV-1 B'/C recombinant (JL10091) in Jilin originated from India subtype C and China subtype B' may suggest potential transmission routes of HIV-1 in China. Further monitoring of the molecular epidemiology of the HIV-1 epidemic in Jilin will provide critical information for designing effective control and prevention measures against HIV transmission in the region.
authors.affiliation: 1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, China .
authors.forename: Chuanyi
authors.initials: C
authors.lastname: Ning
authors.forename: Xingguang
authors.initials: X
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.forename: Kunxue
authors.initials: K
authors.lastname: Hong
authors.forename: Rongge
authors.initials: R
authors.lastname: Yang
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
mesh_terms: D002681:China / Q000453:epidemiology; D003075:Coitus; D005260:Female; D015750:Genes, gag; D015751:Genes, pol; D016679:Genome, Viral; D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic