title: Serum adiponectin and resistin levels in de novo and relapsed acute lymphoblastic leukemia children patients.
abstract: BACKGROUND
  Adipose tissue secretes a large number of adipocytokines such as leptin, resistin, and adiponectin. Many of these hormones and cytokines are altered in obese individuals and may lead to disruption of the normal balance between cell proliferation, differentiation, and apoptosis. The aim of our work was to investigate the disturbance of secretion of adiponectin and resistin in de novo and relapsed acute lymphoblastic leukemia (ALL) in Egyptian children and determine whether adiponectin and resistin are implicated in increased risk relapse compared to healthy individuals.
  
  
  METHODS
  Measurements of adiponectin and resistin were performed at diagnosis, in 32 patients with de novo ALL aged 3 to 18 years (mean 9.8 y) and 19 children with relapsed ALL aged 5 to 17 (mean 9.9 yr). 10 apparently healthy children with matched age and sex were used as controls.
  
  
  RESULTS
  Mean adiponectin levels were low (P < 0.05), whereas mean resistin levels were high (P<0.05) at diagnosis and relapsed ALL (compared to healthy controls). A significant decrease of adiponectin levels was observed in relapsed ALL compared to de novo ALL. In contrast resistin was significantly increased in relapsed ALL compared to de novo patients. Adiponectin in ALL subjects inversely correlated with resistin level (r = -0.51, P < 0.001).
  
  
  CONCLUSIONS
  Low adiponectin and high resistin level at diagnosis suggest their implication in ALL pathogenesis and may serve as potential clinically significant diagnostic markers to detect leukemic relapse.
authors.affiliation: Dept. of Biochemistry, Genetic Engineering and Biotechnology Division, National Research Centre, Cairo, Egypt ; Dept. of Clinical Biochemistry, Faculty of Medicine, North Jeddah Branch, King Abdulaziz University, Jeddah, KSA.
authors.forename: Hatim A
authors.initials: HA
authors.lastname: El-Baz
authors.forename: Tamer E
authors.initials: TE
authors.lastname: Mosa
authors.forename: Elham M
authors.initials: EM
authors.lastname: Elabd
authors.forename: Amal
authors.initials: A
authors.lastname: Ramadan
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Elharoun
authors.forename: Elsayed A
authors.initials: EA
authors.lastname: Elmorsy
authors.forename: Manal I
authors.initials: MI
authors.lastname: Fouda
keywords: Acute lymphoblastic leukemia; Adiponectin; Resistin