title: Amyloid deposition and cognition in older adults: the effects of premorbid intellect.
abstract: Although amyloid deposition remains a marker of the development of Alzheimer's disease, results linking amyloid and cognition have been equivocal. Twenty-five community-dwelling non-demented older adults were examined with (18)F-flutemetamol, an amyloid imaging agent, and a cognitive battery, including an estimate of premorbid intellect and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). In the first model, (18)F-flutemetamol uptake significantly correlated with the Delayed Memory Index of the RBANS (r = -.51, p = .02) and premorbid intellect (r = .43, p = .03). In the second model, the relationship between (18)F-flutemetamol and cognition was notably stronger when controlling for premorbid intellect (e.g., three of the five RBANS Indexes and its Total score significantly correlated with (18)F-flutemetamol, r's = -.41 to -.58). Associations were found between amyloid-binding (18)F-flutemetamol and cognitive functioning in non-demented older adults. These associations were greatest with delayed memory and stronger when premorbid intellect was considered, suggesting that cognitive reserve partly compensates for the symptomatic expression of amyloid pathology in community-dwelling elderly.
authors.affiliation: Center for Alzheimer's Care, Imaging, and Research, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Duff
authors.forename: Norman L
authors.initials: NL
authors.lastname: Foster
authors.forename: Kathryn
authors.initials: K
authors.lastname: Dennett
authors.forename: Dustin B
authors.initials: DB
authors.lastname: Hammers
authors.forename: Lauren V
authors.initials: LV
authors.lastname: Zollinger
authors.forename: Paul E
authors.initials: PE
authors.lastname: Christian
authors.forename: Regan I
authors.initials: RI
authors.lastname: Butterfield
authors.forename: Britney E
authors.initials: BE
authors.lastname: Beardmore
authors.forename: Angela Y
authors.initials: AY
authors.lastname: Wang
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Morton
authors.forename: John M
authors.initials: JM
authors.lastname: Hoffman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D000682:Amyloid / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography
chemical_list: D000682:Amyloid
keywords: Alzheimer's disease; Amyloid; Neuroimaging; Neuropsychology; Premorbid intellect