title: [Studying of hepatoprotective properties of dry extract from apricot leaves on the model of liver lesion by tetrachloromethane].
abstract: The results of the pharmacological investigation of the properties of apricot leaves dry extract are indicated in the article. It is proved that the extract belongs to the group of "relatively harmless" substances, exclusion of the ulcerogenic effect on the stomach, local irritating and allergenic effect on animals. It is found minimal reacting dose of the extract, which is 70 mg/kg of body weight. On the model of liver lesion by tetrachlormethane it is proved the antioxidant properties of the extract, which is manifested by the decreasing of the activity of oxidative processes and the resumption of the activity of the endogenous antioxidant system. At the studying of the bile formation and bile secretion functions in the conditions of the toxic tetrachlormethane lesion the hepatoprotective effect of the dosage form was confirmed, which was realized by the increasing of the speed of bile secretion and its volume. It is proved a positive effect of the extract on the detoxification function of the liver, that is confirmed by the reducing of the hexenal sleep in rats after toxicant exposure.
authors.forename: A L
authors.initials: AL
authors.lastname: Shtroblia
authors.forename: L S
authors.initials: LS
authors.lastname: Fira
authors.forename: P G
authors.initials: PG
authors.lastname: Likhatskiĭ
authors.forename: V P
authors.initials: VP
authors.lastname: Pyla
authors.forename: E M
authors.initials: EM
authors.lastname: Vashkeba
authors.forename: I I
authors.initials: II
authors.lastname: Medvid'
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005978:Glutathione / Q000097:blood; D006168:Guinea Pigs; D006834:Hydrazines / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D027861:Prunus / Q000737:chemistry*; D011817:Rabbits; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D006834:Hydrazines; D010936:Plant Extracts; D020011:Protective Agents; C446799:dinitrophenylhydrazine; D002784:Cholesterol; D002251:Carbon Tetrachloride; D002374:Catalase; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D005978:Glutathione