title: [Bloodstream infections after liver and hematopoietic stem cell transplantation].
abstract: The aim of this retrospective study was to evaluate and compare the incidence, timing and etiology of bloodstream infections (BSIs) in patients treated with liver-(LT) or hematopoietic stem cell transplantation (HSCT) in a single institution. We evaluated 280 consecutive transplantations over a period of 34 months. Our results demonstrated 84 episodes of BSIs (47 in LT patients and 37 in HSCT patients) at a median of 28 days post-transplantation. Relative incidence of 34.6 and 29.4 BSI episodes per 100 LT and HSCT patients, respectively, did not differ significantly between the two groups (p = 0.52). BSIs in HSCT patients occurred significantly earlier (p = 0.003) than in LT patients. The recently described reemergence of gram-negative (GN) pathogens as causative agents of BSIs in these patients was confirmed: GN bacilli were the predominant isolates in the LT group, responsible for 58.5% of BSIs and a very frequent (39%) cause of BSIs in the HSCT group. A higher incidence of resistant enterobacteriaceae producing extended spectrum beta-lactamases was found in isolates from LT patients compared to HSCT patients. In both groups, Pseudomonas aeruginosa was the most difficult to treat organism, with 57% of these isolates in LT patients and 44% in HSCT patients being resistant to carbapenems. To conclude, BSIs were confirmed to be important infectious complications of both LT and HSCT. Surveillance and analysis of bacteria causing bloodstream and other serious infections in transplanted patients remain the main prerequisites for planning interventions regarding prevention and treatment of infections in these patients.
authors.affiliation: Klinika za unutarnje bolesti, Klinicka bolnica Merkur, Medicinski fakultet Sveucilista u Zagrebu, Zagreb, Hrvatska.
authors.forename: Zinaida
authors.initials: Z
authors.lastname: Perić
authors.forename: Arjana
authors.initials: A
authors.lastname: Tambić-Andrasević
authors.forename: Ana
authors.initials: A
authors.lastname: Mrzljak
authors.forename: Iva
authors.initials: I
authors.lastname: Kosuta
authors.forename: Visnja
authors.initials: V
authors.lastname: Kovacević
authors.forename: Denis
authors.initials: D
authors.lastname: Gustin
authors.forename: Radovan
authors.initials: R
authors.lastname: Vrhovac
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D018805:Sepsis / Q000209:etiology* / Q000382:microbiology; D055815:Young Adult