title: IL-10 control of dendritic cells in the skin.
abstract: Interleukin-10 (IL-10) is a potent immunomodulatory cytokine, whose cellular targets have not yet been precisely identified. Dendritic cell (DC)-specific IL-10 receptor knockout mice exhibit exaggerated T-cell reactivation in the skin, highlighting a key role of DCs in the maintenance of local immune homeostasis, beyond their classical function as regulators of T-cell priming in lymph nodes.
authors.affiliation: Department of Immunology; Erasmus MC; University Medical Center; Rotterdam, The Netherlands ; Institute for Molecular Medicine; University Medical Center of the Johannes Gutenberg-University; Mainz, Germany.
authors.forename: Björn E
authors.initials: BE
authors.lastname: Clausen
authors.forename: Mathilde J H
authors.initials: MJ
authors.lastname: Girard-Madoux
keywords: IL-10 receptor signaling; Langerhans cells; conditional gene targeting; contact hypersensitivity; dendritic cells; immune regulation; interleukin-10; skin