title: Imidazoles as potential antifungal agents: a review.
abstract: Imidazoles are one of the most promising and vigorously pursued areas of contemporary antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively simple molecular nucleus, which is amenable to many structural modifications. These agents have several favorable properties such as excellent bioavailability, good tissue penetrability and permeability and a relatively low incidence of adverse and toxic effects. They have been found effective in the treatment of various infectious diseases. This paper is an attempt to review the therapeutic potential of imidazoles as antifungal with an updated account on their development.
authors.affiliation: Himalayan Institute of Pharmacy, Kala-Amb, Distt. Sirmour, Himachal Pradesh, India. nidhiprajapati8@gmail.com
authors.forename: Nidhi
authors.initials: N
authors.lastname: Rani
authors.forename: Ajay
authors.initials: A
authors.lastname: Sharma
authors.forename: Girish Kumar
authors.initials: GK
authors.lastname: Gupta
authors.forename: Randhir
authors.initials: R
authors.lastname: Singh
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D009181:Mycoses / Q000188:drug therapy; D010330:Patents as Topic; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles