title: Small bite-angle P-OP ligands for asymmetric hydroformylation and hydrogenation.
abstract: A series of small bite-angle phosphine-phosphite (P-OP) ligands have been synthesized by a two-step method. The key intermediate was prepared by an unprecedented asymmetric carbonyl reduction of a phosphamide using the CBS (Corey-Bakshi-Shibata) catalyst. The topology of these ligands (a configurationally stable stereogenic carbon with two heteroatom substituents) and their small bite-angle (created by the close proximity of the two ligating groups to the metal center) together provide a rigid asymmetric environment around this center, enabling high stereoselectivity in hydroformylations and hydrogenations of standard substrates.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Héctor
authors.initials: H
authors.lastname: Fernández-Pérez
authors.forename: J
authors.initials: J
authors.lastname: Benet-Buchholz
authors.forename: Anton
authors.initials: A
authors.lastname: Vidal-Ferran