title: The effect of α-cyclodextrin on postprandial lipid and glycemic responses to a fat-containing meal.
abstract: OBJECTIVE
  α-Cyclodextrin (α-CD), a soluble dietary fiber derived from corn, marketed under the trade name FBCx®, has the potential to help individuals manage their weight and improve their lipid profiles. Initial studies in healthy overweight and/or obese diabetic individuals found that, in those consuming a normal to high fat diet over a 4 or 12 week period, α-CD use was associated with weight loss or maintenance and a reduction in triglyceride (TG) and cholesterol levels in hyperlipidemic individuals. Furthermore, α-CD use was associated with the positive effects of increasing insulin and leptin sensitivities. To date, the immediate post-prandial glucose and lipid responses to a fat-containing meal have not been reported.
  
  
  METHODS
  This double blinded placebo controlled cross-over trial examined the effect of 2 g of α-CD taken immediately following consumption of a commercially prepared high-fat breakfast meal on the acute postprandial responses in healthy adults.
  
  
  RESULTS
  The coincidental consumption of α-CD with a fat-containing meal was associated with a significant reduction in postprandial TG responses over time when compared to placebo. When incremental area under the curve was calculated, the area under the curve associated with α-CD consumption was significantly smaller than the Placebo area (0.30±1.07 mmol/L/3 h vs. 0.98±0.88 mmol/L/3 h, p<0.05). There were no significant changes in glucose or cholesterol levels.
  
  
  CONCLUSIONS
  α-Cyclodextrin was shown to significantly lower acute postprandial blood triglyceride levels.
authors.affiliation: College of Nursing, Wayne State University, Detroit, MI 48202, USA. Electronic address: ad9433@wayne.edu.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Jarosz
authors.forename: Evan
authors.initials: E
authors.lastname: Fletcher
authors.forename: Eman
authors.initials: E
authors.lastname: Elserafy
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Artiss
authors.forename: K-L Catherine
authors.initials: KL
authors.lastname: Jen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects; D004043:Dietary Fiber / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D062407:Meals; D008875:Middle Aged; D019518:Postprandial Period / Q000187:drug effects* / Q000502:physiology; D014280:Triglycerides / Q000097:blood; D055815:Young Adult; D047391:alpha-Cyclodextrins / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D004043:Dietary Fiber; D008055:Lipids; D014280:Triglycerides; D047391:alpha-Cyclodextrins; D002784:Cholesterol; D005947:Glucose; C032613:alpha-cyclodextrin
keywords: Dietary fiber; HDL-C; HFD; LDL-C; Obesity; SD; TC; TG; Triglycerides; Weight loss; high density lipoprotein cholesterol; high fat diet; low density lipoprotein cholesterol; standard deviations; total cholesterol; triglyceride; α-CD; α-Cyclodextrin; α-cyclodextrin