title: IGF2 revs the steroidogenesis engine.
abstract: Molecular understanding of how prostate cancers evade hormone therapy greatly increased over the last several years, and the realization that de novo steroidogenesis plays a significant role in tumor progression and therapeutic bypass has led to development of promising new therapeutics. In the April 2013 issue of Endocrine-Related Cancer, Lubik et al. revealed a new molecular pathway by which the IGF2 can ignite the de novo steroidogenesis engine and promote molecular events associated with tumor progression.
authors.affiliation: Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
authors.forename: Clay E S
authors.initials: CE
authors.lastname: Comstock
authors.forename: Karen E
authors.initials: KE
authors.lastname: Knudsen
mesh_terms: D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000494:pharmacology*; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism*; D013256:Steroids / Q000096:biosynthesis*
chemical_list: D013256:Steroids; D007335:Insulin-Like Growth Factor II
keywords: IGF2; steroidogenesis