title: Acute splenic syndrome in an African-American male with sickle cell trait on a commercial airplane flight.
abstract: BACKGROUND
  Patients with sickle cell trait (SCT) generally suffer few effects of sickle cell disease. Acute splenic syndrome is a rare but well-documented complication of SCT that can present in the setting of low oxygen tension that occurs with major changes in altitude, either by unpressurized air flight or ground travel such as mountain climbing.
  
  
  OBJECTIVE
  Our objective was to increase emergency physician awareness of the rare diagnosis of altitude-induced splenic infarction in patients with SCT by presenting and reviewing recorded literature.
  
  
  METHODS
  This is an unusual case of a man with SCT who suffered acute splenic syndrome while on a pressurized airplane flight subsequently requiring splenectomy.
  
  
  CONCLUSIONS
  Although it is a rare phenomenon, patients with SCT who are exposed to high altitudes can be subject to splenic syndrome. There are many patients who are unaware that they have SCT, which makes the diagnosis challenging for emergency physicians. In addition, because patients with SCT generally do not have complications related to their disease, diagnosing splenic syndrome might be delayed, potentially resulting in inadequate hydration, pain management, and other supportive treatment, which ultimately leads to worsening splenic syndrome and splenectomy.
authors.affiliation: Department of Emergency Medicine, University of Medicine and Dentistry of New Jersey, Newark, New Jersey.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Murano
authors.forename: Adam D
authors.initials: AD
authors.lastname: Fox
authors.forename: Devashish
authors.initials: D
authors.lastname: Anjaria
mesh_terms: D000337:Aerospace Medicine; D001741:Black or African American; D064870:Air Travel; D000531:Altitude; D006801:Humans; D008297:Male; D008875:Middle Aged; D012805:Sickle Cell Trait / Q000150:complications*; D013156:Splenectomy; D013159:Splenic Infarction / Q000209:etiology*; D013577:Syndrome
keywords: high-altitude; infarction; sickle cell trait; splenic syndrome