title: AnE/Zconformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.
abstract: An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids5and6, and their primary (nonmethylated) congeners1aand2, based on theirE/Zconformational behaviour in DMSO, is presented.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens , Panepistimioupoli-Zografou, GR-15771 Athens, Greece.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Tsatsaroni
authors.forename: Grigoris
authors.initials: G
authors.lastname: Zoidis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Zoumpoulakis
authors.forename: Andrew
authors.initials: A
authors.lastname: Tsotinis
authors.forename: Martin C
authors.initials: MC
authors.lastname: Taylor
authors.forename: John M
authors.initials: JM
authors.lastname: Kelly
authors.forename: George
authors.initials: G
authors.lastname: Fytas
keywords: E/Z conformational behaviour; Lipophilic hydroxamic acid derivatives; Molecular modelling studies; NMR; Trypanocidal action