title: A novel type of highly effective nonionic gemini alkyl O-glucoside surfactants: a versatile strategy of design.
abstract: A novel type of highly effective gemini alkyl glucosides has been rationally designed and synthesized. The gemini surfactants have been readily prepared by glycosylation of the gemini alkyl chains that are synthesized with regioselective ring-opening of ethylene glycol epoxides by the alkyl alcohols. The new gemini alkyl glucosides exhibit significantly better surface activity than the known results. Then rheological, DLS, and TEM studies have revealed the intriguing self-assembly behavior of the novel gemini surfactants. This study has proved the effectiveness of the design of gemini alkyl glucosides which is modular, extendable, and synthetically simple. The new gemini surfactants have great potential as nano carriers in drug and gene delivery.
authors.affiliation: Department of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. songbailiu@zju.edu.cn
authors.forename: Songbai
authors.initials: S
authors.lastname: Liu
authors.forename: Ruocheng
authors.initials: R
authors.lastname: Sang
authors.forename: Shan
authors.initials: S
authors.lastname: Hong
authors.forename: Yujing
authors.initials: Y
authors.lastname: Cai
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
mesh_terms: D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D013499:Surface Properties; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D005960:Glucosides; D013501:Surface-Active Agents