title: Malignant bladder pheochromocytoma with SDHB genetic mutation.
abstract: A 30-year-old man presented with micturition pain and was diagnosed with a submucosal tumor in the right wall of the bladder with metastasis to the right obturator lymph node. Transurethral resection led to a diagnosis of invasive malignant pheochromocytoma. Radical cystectomy, neobladder reconstruction and bilateral iliac lymph node dissection were performed. Genetic analysis revealed succinate dehydrogenase B-associated hereditary pheochromocytoma/paraganglioma syndrome. 10 months after the operation, he had no evidence of recurrence.
authors.affiliation: Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: Y
authors.initials: Y
authors.lastname: Funahashi
authors.forename: M
authors.initials: M
authors.lastname: Katoh
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Tsuruta
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
mesh_terms: D000328:Adult; D015653:Cystectomy; D003558:Cystoscopy; D004252:DNA Mutational Analysis; D005820:Genetic Testing; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D010235:Paraganglioma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D049268:Positron-Emission Tomography; D013385:Succinate Dehydrogenase / Q000235:genetics*; D014057:Tomography, X-Ray Computed; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D016476:Urinary Reservoirs, Continent
chemical_list: C108095:SDHB protein, human; D013385:Succinate Dehydrogenase