title: In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy.
abstract: Real-time monitoring of betaine aldehyde metabolism at high temporal resolution was accomplished using a hyperpolarized choline analog and (13)C-NMR. This represents the first observation of an aldehyde intermediate on hyperpolarized MR and opens the way for kinetic studies of oxidase/dehydrogenase enzymes in vitro and in vivo.
authors.affiliation: Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel.
authors.forename: Hyla
authors.initials: H
authors.lastname: Allouche-Arnon
authors.forename: Ayelet
authors.initials: A
authors.lastname: Gamliel
authors.forename: Jacob
authors.initials: J
authors.lastname: Sosna
authors.forename: J Moshe
authors.initials: JM
authors.lastname: Gomori
authors.forename: Rachel
authors.initials: R
authors.lastname: Katz-Brull
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism; D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry; D002247:Carbon Isotopes / Q000737:chemistry; D002794:Choline / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction
chemical_list: D002247:Carbon Isotopes; D001622:Betaine; C026820:betaine aldehyde; D000429:Alcohol Oxidoreductases; D002794:Choline