title: Calcineurin-dependent ion channel regulation in heart.
abstract: Calcineurin, a serine-threonine-specific, Ca(2+)-calmodulin-activated protein phosphatase, conserved from yeast to humans, plays a key role in regulating cardiac development, hypertrophy, and pathological remodeling. Recent studies demonstrate that calcineurin regulates cardiomyocyte ion channels and receptors in a manner which often entails direct interaction with these target proteins. Here, we review the current state of knowledge of calcineurin-mediated regulation of ion channels in the myocardium with emphasis on the transient outward potassium current (Ito) and L-type calcium current (ICa,L). We go on to discuss unanswered questions that surround these observations and provide perspective on future directions in this exciting field.
authors.affiliation: Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Department of Pediatrics, Emory University, Atlanta, GA, USA. Electronic address: yanggan.wang@emory.edu.
authors.forename: Yanggan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine (Cardiology), University of Texas, Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Samvit
authors.initials: S
authors.lastname: Tandan
authors.affiliation: Department of Internal Medicine (Cardiology), University of Texas, Southwestern Medical Center, Dallas, TX, USA; Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, TX, USA. Electronic address: joseph.hill@utsouthwestern.edu.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hill
mesh_terms: D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000378:metabolism; D006331:Heart Diseases / Q000201:enzymology / Q000503:physiopathology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008564:Membrane Potentials; D009206:Myocardium / Q000201:enzymology*; D032383:Myocytes, Cardiac / Q000201:enzymology*; D015221:Potassium Channels / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D020746:Calcium Channels, L-Type; D007473:Ion Channels; D015221:Potassium Channels; D019703:Calcineurin