title: Synthesis and antiproliferative activity of the heterobimetallic complexes [RuClCp(PPh₃)-μ-dmoPTA-1κP:2κ²N,N'-MCl₂] (M = Co, Ni, Zn; dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane).
abstract: The synthesis and characterization of three novel heterobimetallic derivatives of general formula [RuClCp(PPh₃)-μ-dmoPTA-1κP:2κ²N,N'-MCl₂] (M = Co (1), Ni (2) and Zn (3), dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane) are described. The sizes of their diffusing units are in agreement with the solid-state structures of 2 and 3, supporting a similar solid-state structure for complex 1. The diamagnetic ruthenium-zinc derivative 3 was fully characterized in solution at 193 K by NMR. Electrochemical properties of the complexes were investigated by cyclic voltammetry, supporting the influence of the {MCl₂} moiety on the electronic properties of the Ru-unit. For the three complexes the GI₅₀ values were in the range 0.8-6.5 μM and comparable to those of the standard anticancer drug cis-platin in the same cell lines.
authors.affiliation: Área de Química Inorgánica, Facultad de Ciencias Experimentales, Universidad de Almería, 04071 Almería, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano-Ruiz
authors.forename: Luis Manuel
authors.initials: LM
authors.lastname: Aguilera-Sáez
authors.forename: Pablo
authors.initials: P
authors.lastname: Lorenzo-Luis
authors.forename: José M
authors.initials: JM
authors.lastname: Padrón
authors.forename: Antonio
authors.initials: A
authors.lastname: Romerosa
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D018360:Crystallography, X-Ray; D055664:Electrochemical Techniques; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D003035:Cobalt; D009532:Nickel; D012428:Ruthenium; D015032:Zinc