title: Zinc finger peptide cleavage by a dinuclear platinum compound.
abstract: Electrospray ionisation mass spectrometry (ESI-MS) and {(1)H, (15)N HSQC} NMR spectroscopy has elucidated the binding of a dinuclear platinum compound to a zinc finger peptide with induced backbone cleavage. Cleavage is selective on the N-terminal side of the cysteine residue following incubation at neutral pH, and is further dependent on structure of dinuclear compound.
authors.affiliation: The RNA Institute, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Mangrum
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Zgani
authors.forename: Samantha D
authors.initials: SD
authors.lastname: Tsotsoros
authors.forename: Yun
authors.initials: Y
authors.lastname: Qu
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Farrell
mesh_terms: D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D016335:Zinc Fingers
chemical_list: D009944:Organoplatinum Compounds; D010455:Peptides