title: Association between vitamin D receptor gene Cdx2 polymorphism and breast cancer susceptibility.
abstract: Vitamin D receptor (VDR) gene polymorphisms have been reported to influence susceptibility to breast cancer. However, published findings on the association between VDR Cdx2 polymorphism and breast cancer susceptibility are conflicting. To get a precise estimation of the association between VDR Cdx2 polymorphism and breast cancer susceptibility, we conducted a meta-analysis of four case-control studies with a total of 8,880 subjects (3,841 cases and 5,039 controls). The results showed that VDR Cdx2 polymorphism was not associated with risk of breast cancer (A versus G: OR = 0.96, 95% CI 0.84-1.09; AA versus GG: OR = 0.97, 95% CI 0.64-1.45; AA/GA versus GG: OR = 0.94, 95% CI 0.80-1.10; AA versus GG/GA: OR = 0.99, 95% CI 0.65-1.51). Subgroup analysis in Caucasians also showed that VDR Cdx2 polymorphism was not associated with risk of breast cancer in Caucasians. However, there was a significant association in Africans (A versus G: OR = 0.75, 95% CI 0.60-0.94; AA versus GG: OR = 0.53, 95% CI 0.29-0.99; AA/GA versus GG: OR = 0.75, 95% CI 0.57-0.97). Therefore, the association between VDR Cdx2 polymorphism and breast cancer susceptibility is only found in Africans. More studies are needed to further assess the association in Asians or Africans.
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Zhu-Chao
authors.initials: ZC
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Zi-Hao
authors.initials: ZH
authors.lastname: Cai
authors.forename: Qun-hua
authors.initials: QH
authors.lastname: Zhang
authors.forename: Zhen-Xin
authors.initials: ZX
authors.lastname: Cai
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Wu
mesh_terms: D001665:Binding Sites / Q000235:genetics; D044383:Black People / Q000235:genetics; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D000071616:CDX2 Transcription Factor; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D015534:Trans-Activators / Q000378:metabolism; D044465:White People / Q000235:genetics
chemical_list: D000071616:CDX2 Transcription Factor; D018398:Homeodomain Proteins; D018167:Receptors, Calcitriol; D015534:Trans-Activators