title: Targeting two co-operating cytokines efficiently shapes immune responses.
abstract: For simultaneously mobilizing the adaptive and innate immune system against cancer, we fused interleukin (IL)-2 and IL-12 to generate a dual cytokine moiety that is targeted to neoplastic lesions by an antibody-binding domain. This approach elicits a broader attack of the immune system against cancer than the use of each cytokine alone.
authors.affiliation: Department I of Internal Medicine; Center for Molecular Medicine Cologne (CMMC); University Hospital Cologne; University of Cologne; Cologne, Germany.
authors.forename: Andreas A
authors.initials: AA
authors.lastname: Hombach
authors.forename: Hinrich
authors.initials: H
authors.lastname: Abken
keywords: Hodgkin's lymphoma; IL-12; IL-2; NK cell; T cell; T helper cell polarization; antibody-cytokine fusion protein; immune therapy