title: The clinicopathologic manifestations of Plasmodium vivax malaria in children: a growing menace.
abstract: BACKGROUND
  Today, India faces increasing morbidity and mortality due to malaria, which is a global health burden. Plasmodium vivax which was once considered to have a benign course, is now being increasingly associated with complicated malaria. Studies which have been done on the increasing virulence of P. Vivax in children, are exceptionally rare.
  
  
  OBJECTIVE
  This study has addressed some of the hitherto unanswered questions, such as: This study has tried to explore the wide spectrum of severe illnesses which are associated with P.vivax malaria in children.Other co-morbid conditions, which include a co-infection with P.falciparum, have been excluded with great care, to assess the increased virulence of P. Vivax.The present study was focused on the paediatric population with a large sample size of 168 subjects.
  
  
  METHODS
  This was an observational retrospective analysis on the clinicopathologic manifestations of the paediatric cases which were admitted with severe malaria due to a mono-infection with Plasmodium vivax, in a tertiary-care centre in the national capital region, India.
  
  
  METHODS
  The diagnosis of the mono-infection with P. Vivax malaria was established by making peripheral blood films (PBFs) and by doing rapid diagnostic tests. The severe forms of malaria were categorized as per the World Health Organization guidelines and the clinical and laboratory findings in these cases of complicated malaria were studied.
  
  
  METHODS
  A descriptive statistical analysis was done by using the SPSS software and an Excel worksheet.
  
  
  RESULTS
  This comprehensive study revealed a multisystem involvement. Abdominal manifestations were observed in 75(45.8%) cases (which included hepatosplenomegaly, hepatomegaly, splenomegaly and ascites) and hepatic dysfunction and jaundice were observed in 28(16.7%) cases. The haematological tests showed moderate to severe anaemia in 151(89.9%) cases and thrombocytopaenia in 138(82.1%) cases. Petechiae were noted in 45(26.8%) cases and a gross bleeding was noted in 9(5.3%) cases. The respiratory findings which included tachypnoea, pleural effusions and ARDS were observed in 22(13.1%) cases. Renal dysfunction was noted clinically in 20(11.9%) cases and biochemically in 16(9.5%) cases. Shock was observed in 7(4.1%) cases, cerebral malaria was observed in 10(5.9%) cases and hypoglycaemia was observed in 5(3%) cases. Multi-organ dysfunction was detected in 11(6.54%) cases. The complications were more severe in the younger children (0-5 years).
  
  
  CONCLUSIONS
  A mono-infection with P. Vivax may lead to severe malaria and this increased virulence has resulted in the changing picture of P. Vivax malaria, leading to a spectrum of complications which are similar to those which are traditionally associated with P. Falciparum.
authors.affiliation: Assistant Professor, Department of Paediatrics.
authors.forename: Prasun
authors.initials: P
authors.lastname: Bhattacharjee
authors.forename: Suparna
authors.initials: S
authors.lastname: Dubey
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Gupta
authors.forename: Prerana
authors.initials: P
authors.lastname: Agarwal
authors.forename: Mathura Prasad
authors.initials: MP
authors.lastname: Mahato
keywords: Complicated malaria; Plasmodium vivax; Severe malaria