title: Polymyxin derivatives: a patent evaluation (WO2012168820).
abstract: The patent application WO201268820 claims a new class of polymyxin derivatives with potent antibacterial activity, especially toward Gram-negative pathogens. Compared to parent polymyxin B (PMB), the new derivatives have more potent antibacterial activity, as well as reduced cytotoxicity against human renal cells.
authors.affiliation: University of South Florida, Department of Chemistry, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
authors.forename: Haifan
authors.initials: H
authors.lastname: Wu
authors.forename: Peng
authors.initials: P
authors.lastname: Teng
authors.forename: Youhong
authors.initials: Y
authors.lastname: Niu
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000187:drug effects; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D010330:Patents as Topic; D011112:Polymyxin B / Q000031:analogs & derivatives / Q000494:pharmacology; D011113:Polymyxins / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011113:Polymyxins; D011112:Polymyxin B