title: Resveratrol attenuates radiation-induced salivary gland dysfunction in mice.
abstract: OBJECTIVE
  In our study we investigated the radioprotective effect of resveratrol (RES) in a murine model of radiation-induced salivary gland dysfunction.
  
  
  METHODS
  Ninety-six Institute of Cancer Research mice were randomly divided into four groups: solvent (group I), RES treated (group II; 20 mg/kg/d), 15 Gy irradiation with solvent treatment (group III), and 15 Gy irradiation with RES treatment (group IV; 15 Gy and 20 mg/kg/d RES). RES (group II and IV) was administered intraperitoneally 3 days prior to irradiation through the conclusion of the experiment.
  
  
  METHODS
  Saliva and submandibular gland tissues were obtained for biochemical, morphological, immunohistochemical, and Western blot analyses at 8 hours, 24 hours, and 30 days after localized irradiation.
  
  
  RESULTS
  Radiation caused a reduction of saliva secretion, salivary amylase activity, superoxide dismutase, and an elevation of malondialdehyde. Administration of RES reversed the reduction of saliva secretion induced by irradiation and restored salivary amylase and superoxide dismutase activity. In addition, RES could inhibit increases in transforming growth factor-β1 expression induced by radiation.
  
  
  CONCLUSIONS
  RES can protect salivary glands against the negative effects of irradiation and has great potential as a treatment for successful radiotherapy in clinical practice.
authors.affiliation: The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Xu
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Cai
authors.forename: Jianxin
authors.initials: J
authors.lastname: Ma
authors.forename: Hongyan
authors.initials: H
authors.lastname: Cheng
authors.forename: Kuiling
authors.initials: K
authors.lastname: Zhao
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
authors.forename: Yuandong
authors.initials: Y
authors.lastname: Cao
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.forename: Qu
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xinchen
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011832:Radiation Injuries / Q000517:prevention & control*; D000077185:Resveratrol; D012466:Salivary Gland Diseases / Q000209:etiology* / Q000517:prevention & control*; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol
keywords: Resveratrol; antioxidant; ionizing radiation; radioprotection; salivary gland dysfunction