title: [Mesonephric (clear cell) cervical cancer].
abstract: Mezonefric cervical cancer was more prevalent in younger women (mean age 42.2 +/- 1.2 years) with no classic predisposing factors. In most cases (62.1%) the localized stage of the disease (I, II stages) dominated. Regional metastases correlated with depth of tumor invasion (with a depth of invasion of more than 10 mm--57.8%). There was marked low expression of HER2/neu (only in 1 of 14 samples it was revealed light positive reaction. Proliferation index Ki-67 was 37.5% and the signs of mutation in the p53 gene were found in 28.4% of cases. Estimating that two thirds of patients with clear-cervical cancer revealed localized forms of the disease, and that most of the women had received the combination treatment (51.8%)--a 5-year survival rate was quite high and was 79.3%.
authors.forename: D I
authors.initials: DI
authors.lastname: Khalimbekova
authors.forename: E A
authors.initials: EA
authors.lastname: Ul'rikh
authors.forename: D E
authors.initials: DE
authors.lastname: Matsko
authors.forename: A F
authors.initials: AF
authors.lastname: Urmancheeva
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry* / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D000328:Adult; D017677:Age Distribution; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008650:Mesonephros / Q000473:pathology; D015995:Prevalence; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D012426:Russia / Q000453:epidemiology; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human