title: Brain Metabolic Dysfunction in Capgras Delusion During Alzheimer's Disease: A Positron Emission Tomography Study.
abstract: Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since little is known regarding the neural correlates of Capgras syndrome, the cerebral metabolic pattern of a patient with probable Alzheimer's disease (AD) and Capgras syndrome was compared with those of 24-healthy elderly participants and 26 patients with AD without delusional syndrome. Comparing the healthy group with the AD group, the patient with AD had significant hypometabolism in frontal and posterior midline structures. In the light of current neural models of face perception, our patients with Capgras syndrome may be related to impaired recognition of a familiar face, subserved by the posterior cingulate/precuneus cortex, and impaired reflection about personally relevant knowledge related to a face, subserved by the dorsomedial prefrontal cortex.
authors.affiliation: Université de Liège, Centre de Recherches du Cyclotron, Liège, Belgium Département des sciences cliniques, Neuroimagerie des troubles de la mémoire et de la revalidation cognitive, Université de Liège, Liège, Belgium Haroun.jedidi@student.ulg.ac.be.
authors.forename: H
authors.initials: H
authors.lastname: Jedidi
authors.affiliation: Département de Psychologie: cognition et comportement, Université de Liège, Liège, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: Daury
authors.affiliation: Département de Psychologie: cognition et comportement, Université de Liège, Liège, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Capa
authors.affiliation: Université de Liège, Centre de Recherches du Cyclotron, Liège, Belgium.
authors.forename: M A
authors.initials: MA
authors.lastname: Bahri
authors.affiliation: Université de Liège, Centre de Recherches du Cyclotron, Liège, Belgium Département de Psychologie: cognition et comportement, Université de Liège, Liège, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Collette
authors.affiliation: Université de Liège, Centre de Recherches du Cyclotron, Liège, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Feyers
authors.affiliation: Université de Liège, Centre de Recherches du Cyclotron, Liège, Belgium Département des sciences cliniques, Neuroimagerie des troubles de la mémoire et de la revalidation cognitive, Université de Liège, Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Bastin
authors.affiliation: Université de Liège, Centre de Recherches du Cyclotron, Liège, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Maquet
authors.affiliation: Université de Liège, Centre de Recherches du Cyclotron, Liège, Belgium Département des sciences cliniques, Neuroimagerie des troubles de la mémoire et de la revalidation cognitive, Université de Liège, Liège, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Salmon
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D002194:Capgras Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D003702:Delusions / Q000209:etiology / Q000503:physiopathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography / Q000379:methods
keywords: brain glucose metabolism; capgras; delusion of misidentification; face recognition; neuroimaging