title: Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs.
abstract: Thirty-one dogs with patellar luxation (grades 2 and 3) were categorized into three groups. Group 1 (G.1; n = 12) had sodium hyaluronate (SHA) intra-articularly injected into the stifle joint that received surgery. Group 2 (G.2; n = 10) received SHA twice: first after surgery and then 1 week later. Group 3 (G.3; n = 9) served as a control, without injection. Blood was collected before injection and then once a week for 4 weeks after injection for evaluation of chondroitin sulfate (CS-WF6) and hyaluronan (HA). The results revealed significantly (p < 0.05) improved clinical scores by the end of week 4 in G.1 and G.2 relative to G.3; however, there was no significant difference between G.1 and G.2. There was a significant decrease (p < 0.05) in serum CS-WF6 levels beginning at week 2 in G.1 and G.2. At weeks 3 and 4, serum HA in G.1 and G.2 differed from that in G.3 (p < 0.05). No significant difference (p > 0.05) was observed in serum biomarkers between G.1 and G.2. In conclusion, intra-articular injection with SHA after joint surgery may improve homeostasis of the joint, retarding the process of OA.
authors.affiliation: Animal Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand. korakot.n@cmu.ac.th
authors.forename: Korakot
authors.initials: K
authors.lastname: Nganvongpanit
authors.forename: Burin
authors.initials: B
authors.lastname: Boonsri
authors.forename: Thatdanai
authors.initials: T
authors.lastname: Sripratak
authors.forename: Patsanan
authors.initials: P
authors.lastname: Markmee
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D002809:Chondroitin Sulfates / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000378:metabolism; D007270:Injections, Intra-Articular / Q000662:veterinary; D008297:Male; D020370:Osteoarthritis, Knee / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D013264:Stifle / Q000601:surgery*; D055675:Viscosupplements / Q000008:administration & dosage*
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates
keywords: biomarker; dog; joint surgery; osteoarthritis; sodium hyaluronate