title: TREM-1 inhibition attenuates inflammation and tumor within the colon.
abstract: The role of myeloid cell receptor TREM-1 as an amplifier of inflammation has been widely accepted and more interestingly, TREM-1 has been implicated in tumorigenesis. However, it is not clear whether TREM-1 links colon inflammation and tumor in vivo. This study aimed to investigate whether inhibition of proinflammatory TREM-1 would prevent aberrant inflammation and tumor development within the colon. In the present study, the mouse model of DSS-induced colitis and colitis-associated tumorigenesis was used. In vivo, the treatment with the TREM-1 antagonist LP17 or control peptide was initiated at the beginning of or after induction of experimental colitis or colitis-associated tumorigenesis. As a result, TREM-1 inhibition by LP17 treatment ameliorated the development of inflammation and tumor within the colon through exerting anti-inflammatory effects. In addition, LP17 decreased intestinal epithelial proliferation in DSS-induced colitis. Taken together, TREM-1 plays critical roles in colon inflammation and tumor and targeting TREM-1 may represent a novel therapeutic strategy for colon inflammation and associated cancer.
authors.affiliation: Department of Oncology, Zhejiang Xiaoshan Hospital, Hangzhou, China.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Chai
authors.forename: Guang
authors.initials: G
authors.lastname: Lu
authors.forename: Guoping
authors.initials: G
authors.lastname: Hang
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D003092:Colitis / Q000139:chemically induced / Q000150:complications / Q000276:immunology*; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003110:Colonic Neoplasms / Q000209:etiology*; D016264:Dextran Sulfate / Q000008:administration & dosage; D004195:Disease Models, Animal; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D058990:Molecular Targeted Therapy; D022423:Myeloid Cells / Q000276:immunology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D008562:Membrane Glycoproteins; D010446:Peptide Fragments; D011971:Receptors, Immunologic; C517262:TREM1 protein, mouse; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D016264:Dextran Sulfate
keywords: Colon; Inflammation; TREM-1; Tumor development