title: Pharmacological resolution of a multiloculated Candida spp. liver abscess in a preterm neonate.
abstract: We report the case of a 31-week gestational age neonate with Candida albicans sepsis and a hepatic abscess. Diagnosis relied on clinical and radiological signs of sepsis, liver function impairment and culture isolation of Candida spp. from sterile sites. Liver ultrasound documented the presence of a multiloculated abscess. Treatment with micafungin (3 mg/kg/day) resulted in normalization of liver function and inflammatory laboratory values and improvement of clinical condition. After 30 days of treatment, the liver abscess resolved and at the 8-month follow up the infant is doing well. Prompt diagnosis and antifungal treatment avoided surgical drainage and liver surgery in this high-risk neonate.
authors.affiliation: Division of Neonatology-NICU Policlinico Casilino General Hospital, Rome, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Picone
authors.forename: Paolo
authors.initials: P
authors.lastname: Manzoni
authors.forename: Manuela
authors.initials: M
authors.lastname: Bedetta
authors.forename: Michael
authors.initials: M
authors.lastname: Mostert
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Benjamin
authors.forename: Piermichele
authors.initials: P
authors.lastname: Paolillo
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D054714:Echinocandins / Q000627:therapeutic use*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D055666:Lipopeptides / Q000627:therapeutic use*; D008099:Liver / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D008100:Liver Abscess / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D000077551:Micafungin; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin