title: Plasma lipidomic profile signature of hypertension in Mexican American families: specific role of diacylglycerols.
abstract: Both as a component of metabolic syndrome and as an independent entity, hypertension poses a continued challenge with regard to its diagnosis, pathogenesis, and treatment. Previous studies have documented connections between hypertension and indicators of lipid metabolism. Novel technologies, such as plasma lipidomic profiling, promise a better understanding of disorders in which there is a derangement of the lipid metabolism. However, association of plasma lipidomic profiles with hypertension in a high-risk population, such as Mexican Americans, has not been evaluated before. Using the rich data and sample resource from the ongoing San Antonio Family Heart Study, we conducted plasma lipidomic profiling by combining high-performance liquid chromatography with tandem mass spectroscopy to characterize 319 lipid species in 1192 individuals from 42 large and extended Mexican American families. Robust statistical analyses using polygenic regression models, liability threshold models, and bivariate trait analyses implemented in the SOLAR software were conducted after accounting for obesity, insulin resistance, and relative abundance of various lipoprotein fractions. Diacylglycerols, in general, and the DG 16:0/22:5 and DG 16:0/22:6 lipid species, in particular, were significantly associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), as well as liability of incident hypertension measured during 7140.17 person-years of follow-up. Four lipid species, including the DG 16:0/22:5 and DG 16:0/22:6 species, showed significant genetic correlations with the liability of hypertension in bivariate trait analyses. Our results demonstrate the value of plasma lipidomic profiling in the context of hypertension and identify disturbance of diacylglycerol metabolism as an independent biomarker of hypertension.
authors.affiliation: Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA. hkulkarn@txbiomedgenetics.org
authors.forename: Hemant
authors.initials: H
authors.lastname: Kulkarni
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Meikle
authors.forename: Manju
authors.initials: M
authors.lastname: Mamtani
authors.forename: Jacquelyn M
authors.initials: JM
authors.lastname: Weir
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Barlow
authors.forename: Jeremy B
authors.initials: JB
authors.lastname: Jowett
authors.forename: Claire
authors.initials: C
authors.lastname: Bellis
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Dyer
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Johnson
authors.forename: David L
authors.initials: DL
authors.lastname: Rainwater
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.forename: Michael C
authors.initials: MC
authors.lastname: Mahaney
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.forename: Joanne E
authors.initials: JE
authors.lastname: Curran
mesh_terms: D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003430:Cross-Sectional Studies; D004075:Diglycerides / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000208:ethnology; D007333:Insulin Resistance / Q000208:ethnology / Q000502:physiology; D050356:Lipid Metabolism / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D017058:Mexican Americans; D008875:Middle Aged; D053719:Tandem Mass Spectrometry
chemical_list: D004075:Diglycerides; D008055:Lipids
keywords: Mexican Americans; blood pressure; hypertension; lipid species; lipidomics