title: Generating color-coded anatomic muscle maps for correlation of quantitative magnetic resonance imaging analysis with clinical examination in neuromuscular disorders.
abstract: BACKGROUND
  Fatty infiltration of muscles may be seen in many neuromuscular disorders, including glycogen storage disease (GSD), muscular dystrophy, and amyotrophic lateral sclerosis. Recording pathologic involvement of musculature in these patients is cumbersome, given marked disease heterogeneity within each individual. We describe a novel method for simplifying this process and present its application in a patient with GSD type IIIa.
  
  
  METHODS
  A color-coded visual mapping tool was developed based on a commonly used spreadsheet platform.
  
  
  RESULTS
  This tool depicts individual muscle groups as shapes linked to data cells corresponding to quantitative MRI-based measures of fatty infiltration and weakness assessed by physical examination. It allows for rapid evaluation and chronological comparison of all mapped muscle groups on a single graphical sheet, as well as assessment of response to therapy.
  
  
  CONCLUSIONS
  This approach can be applied in any neuromuscular disorder where muscle function is assessed by clinical or imaging scores.
authors.affiliation: Department of Radiology, Duke University Medical Center, DUMC 3808, Durham, North Carolina 27710, USA.
authors.forename: Ramin
authors.initials: R
authors.lastname: Javan
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Horvath
authors.forename: Laura E
authors.initials: LE
authors.lastname: Case
authors.forename: Stephanie
authors.initials: S
authors.lastname: Austin
authors.forename: Jose
authors.initials: J
authors.lastname: Corderi
authors.forename: Alberto
authors.initials: A
authors.lastname: Dubrovsky
authors.forename: Priya S
authors.initials: PS
authors.lastname: Kishnani
authors.forename: Mustafa R
authors.initials: MR
authors.lastname: Bashir
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009132:Muscles / Q000473:pathology*; D009468:Neuromuscular Diseases / Q000473:pathology*; D012720:Severity of Illness Index
keywords: color-coded maps; glycogen storage disease; muscle fat fraction; neuromuscular disorders; whole-body MRI