title: Anti-rPru p 3 IgE levels are inversely related to the age at onset of peach-induced severe symptoms reported by peach-allergic adults.
abstract: Sensitisation to peach lipid transfer protein (LTP; Pru p 3) is significantly associated with severe allergic symptoms in adults, but little is known about the age at onset of peach allergy. We investigated a possible correlation between specific IgE levels to Pru p 3 and the age at onset of peach allergy. One hundred and forty-eight patients allergic to peach were divided into 6 classes according to the age at onset. Sera were analyzed for IgE antibodies to peach, rPru p 3, rPru p 1, rPru p 4, rBet v 1, rBet v 2, total IgE titre, and tryptase; all collected data were statistically analysed. A significant inverse correlation was found between the age at onset of peach allergy and anti-rPru p 3 IgE levels at diagnosis (p < 0.0005; Spearman's ρ = -0.3833). In contrast, the age at onset was directly correlated with both anti-rPru p 1 IgE levels (p = 0.0001; Spearman's ρ = 0.3197) and anti-rBet v 1 IgE levels (p = 0.0006; Spearman's ρ = 0.2914) at diagnosis. No correlations were detected between the reported age at onset and anti-peach, anti-rPru p 4, anti-rBet v 2 IgE and total IgE values and serum tryptase levels. At diagnosis, when peach allergy starts at a younger age, it is likely associated with Pru p 3 sensitisation, and the younger the onset, the higher the IgE titres. When peach allergy starts at an older age, it is more likely the result of cross-reactivity to Bet v1.
authors.affiliation: Allergology and Immunology Unit, Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: Elide Anna
authors.initials: EA
authors.lastname: Pastorello
authors.forename: Laura
authors.initials: L
authors.lastname: Farioli
authors.forename: Chrysi
authors.initials: C
authors.lastname: Stafylaraki
authors.forename: Ambra
authors.initials: A
authors.lastname: Mascheri
authors.forename: Joseph
authors.initials: J
authors.lastname: Scibilia
authors.forename: Valerio
authors.initials: V
authors.lastname: Pravettoni
authors.forename: Laura
authors.initials: L
authors.lastname: Primavesi
authors.forename: Marta
authors.initials: M
authors.lastname: Piantanida
authors.forename: Michele
authors.initials: M
authors.lastname: Nichelatti
authors.forename: Riccardo
authors.initials: R
authors.lastname: Asero
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000888:Antibodies, Anti-Idiotypic; D052179:Antigens, Plant / Q000276:immunology*; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E; D008297:Male; D008875:Middle Aged; D010940:Plant Proteins / Q000276:immunology*; D027861:Prunus
chemical_list: D000888:Antibodies, Anti-Idiotypic; D052179:Antigens, Plant; D010940:Plant Proteins; C463181:Pru p 3 allergen; C026408:anti-IgE antibodies; D007073:Immunoglobulin E