title: c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study.
abstract: OBJECTIVE
  To investigate the role of c-Myc oncogene in selected odontogenic cysts and tumors.
  
  
  METHODS
  Ten cases each of ameloblastoma, adenomatoid odontogenic tumor (AOT), odontogenic keratocyst (OKC), dentigerous cyst, and radicular cyst were selected and primary monoclonal mouse anti-human c-Myc antibody was used in a dilution of 1: 50. Statistical Analysis was performed using Mann Whitney U test.
  
  
  RESULTS
  80% positivity was observed in ameloblastoma, AOT and OKC; 50% positivity in radicular cyst and 20% positivity in dentigerous cyst. Comparison of c-Myc expression between ameloblastoma and AOT did not reveal significant results. Similarly, no statistical significance was observed when results of OKC were compared with ameloblastoma and AOT. In contrast, significant differences were seen on comparison of dentigerous cyst with ameloblastoma and AOT and radicular cyst with AOT.
  
  
  CONCLUSIONS
  From the above data we conclude that (1) Ameloblastoma and AOT have similar proliferative potential and their biologic behavior cannot possibly be attributed to it. (2) OKC has an intrinsic growth potential which is absent in other cysts and reinforces its classification as keratocystic odontogenic tumor.
authors.affiliation: Department of Oral Pathology, HKES' SN Dental College, Gulbarga, Karnataka, India.
authors.forename: Zama
authors.initials: Z
authors.lastname: Moosvi
authors.forename: K
authors.initials: K
authors.lastname: Rekha
keywords: Adenomatoid odontogenic tumor; ameloblastoma; c-Myc oncogene; dentigerous cyst; immunohistochemistry; keratocystic odontogenic tumor; odontogenic keratocyst; radicular cyst