title: Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest.
abstract: A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single pot leading to fused furo N-heterocycles as potential inhibitors of sirtuins. A representative compound showed promising pharmacological properties in vitro and in vivo.
authors.affiliation: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India.
authors.forename: Ali
authors.initials: A
authors.lastname: Nakhi
authors.forename: Md Shafiqur
authors.initials: MS
authors.lastname: Rahman
authors.forename: Guru Pavan Kumar
authors.initials: GP
authors.lastname: Seerapu
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Banote
authors.forename: Kummari Lalith
authors.initials: KL
authors.lastname: Kumar
authors.forename: Pushkar
authors.initials: P
authors.lastname: Kulkarni
authors.forename: Devyani
authors.initials: D
authors.lastname: Haldar
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000818:Animals; D003500:Cyclization; D004305:Dose-Response Relationship, Drug; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006868:Hydrolysis; D008958:Models, Molecular; D015394:Molecular Structure; D011719:Pyrazines / Q000737:chemistry; D011810:Quinoxalines / Q000737:chemistry; D037761:Sirtuins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D015027:Zebrafish / Q000196:embryology
chemical_list: D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D011719:Pyrazines; D011810:Quinoxalines; D037761:Sirtuins