title: Genetic properties of endemic Chinese porcine epidemic diarrhea  virus strains isolated since 2010.
abstract: Acute diarrhea outbreaks caused by porcine epidemic diarrhea virus (PEDV) have been observed in various pig-breeding provinces of China since December 2010. Endemic strains of PEDV were isolated from different areas, and the complete genome sequences of 10 isolates were determined. Our objective in this study was to genetically characterize current Chinese field isolates of PEDV to better understand their epidemiology and genetic diversity. Sequence analysis showed that 10 post-2010 isolates shared high homology with each other and were always clustered together with the virulent DR13 strains (South Korea) and/or one earlier Chinese strain, CH-S, in phylogenetic analysis. All post-2010 isolates possessed common sequence changes in each gene. Our results suggest that current Chinese PEDV isolates originated from either South Korean and/or Chinese ancestors that underwent some genetic variation, thereby forming a new PEDV genotype in China.
authors.forename: Xiao-meng
authors.initials: XM
authors.lastname: Wang
authors.forename: Bei-bei
authors.initials: BB
authors.lastname: Niu
authors.forename: He
authors.initials: H
authors.lastname: Yan
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Gao
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.forename: Hong-tao
authors.initials: HT
authors.lastname: Chang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Chuan-qing
authors.initials: CQ
authors.lastname: Wang
mesh_terms: D000818:Animals; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D018352:Coronavirus Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D003967:Diarrhea / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D019353:Endemic Diseases; D014644:Genetic Variation; D016679:Genome, Viral; D017720:Molecular Epidemiology; D010802:Phylogeny; D053485:Porcine epidemic diarrhea virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology* / Q000821:virology*
chemical_list: D012367:RNA, Viral