title: Corneal endothelial cell density after vitrectomy with silicone oil for complex retinal detachments.
abstract: OBJECTIVE
  To evaluate the endothelial cell density changes in eyes with silicone oil tamponade after vitrectomy for complex rhegmatogenous retinal detachment.
  
  
  METHODS
  A prospective controlled study with 81 eyes with complex rhegmatogenous retinal detachment undergoing vitrectomy and silicone oil tamponade. Fellow eyes that fulfilled specific inclusion criteria served as controls. Endothelial cell density (in cells per square millimeter), coefficient of variance (standard deviation per mean cell area × 100), percentage of hexagonal cells, and corneal thickness were documented preoperatively and compared with values obtained at 3, 6, and 12 months postoperatively. For the purpose of the study analysis, all study eyes were divided into 5 groups, according to their lens status during the follow-up.
  
  
  RESULTS
  High endothelial cell density loss was found in Group 3, (eyes that underwent an additional phacoemulsification procedure) and Group 4 (eyes that underwent lens and/or intraocular lens removal during the follow-up) at 12 months with a mean cell loss of 19% and 39%, respectively (P < 0.001).
  
  
  CONCLUSIONS
  An intact natural or artificial lens-iris diaphragm may provide a protective barrier against corneal endothelial cell damage from long-term silicone oil tamponade.
authors.affiliation: *Department of Ophthalmology, University Eye Clinic Maastricht, Maastricht, The Netherlands; †Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands; and ‡Department of Ophthalmology, Jan van Goyen Clinic, Amsterdam, The Netherlands.
authors.forename: Fleur
authors.initials: F
authors.lastname: Goezinne
authors.forename: Rudy M
authors.initials: RM
authors.lastname: Nuijts
authors.forename: Albert T
authors.initials: AT
authors.lastname: Liem
authors.forename: Igor J
authors.initials: IJ
authors.lastname: Lundqvist
authors.forename: Tos J
authors.initials: TJ
authors.lastname: Berendschot
authors.forename: Diana W
authors.initials: DW
authors.lastname: Cals
authors.forename: Fred
authors.initials: F
authors.lastname: Hendrikse
authors.forename: Ellen C
authors.initials: EC
authors.lastname: La Heij
mesh_terms: D000368:Aged; D002452:Cell Count; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis*; D058450:Endotamponade; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011184:Postoperative Period; D011446:Prospective Studies; D012163:Retinal Detachment / Q000601:surgery*; D012827:Silicone Oils / Q000008:administration & dosage*; D014821:Vitrectomy
chemical_list: D012827:Silicone Oils