title: Elucidating immune mechanisms causing hypertension during pregnancy.
abstract: Preeclampsia is associated with hypertension and increased infant and maternal morbidity and mortality. The underlying cause of preeclampsia is largely unknown, but it is clear that an immunological component plays a key pathophysiological role. This review will highlight immunological key players in the pathology of preeclampsia and discuss their role in the pathophysiology observed in the reduced placental perfusion (RUPP) rat model of preeclampsia.
authors.affiliation: Department of Pharmacology and Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi, USA. bblamarca@umc.edu
authors.forename: Babbette
authors.initials: B
authors.lastname: LaMarca
authors.forename: Denise
authors.initials: D
authors.lastname: Cornelius
authors.forename: Kedra
authors.initials: K
authors.lastname: Wallace
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology; D007107:Immune System / Q000502:physiology*; D010477:Perfusion; D010920:Placenta / Q000098:blood supply; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D051381:Rats; D014599:Uterus / Q000098:blood supply