title: A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils.
abstract: Orchestrating a cytotoxic polymorphonuclear neutrophil (PMN) response strictly focused within the tumor tissue remains a formidable challenge for the successful therapeutic use of these cells. ASalmonellavector carrying an shRNA against indoleamine 2,3-dioxygenase has been shown to recruit PMNs and enhance their activation specifically in the tumor bed, resulting in significant anticancer effects.
authors.affiliation: Division of Translational Vaccine Research; City of Hope; Duarte, CA USA.
authors.forename: Edwin R
authors.initials: ER
authors.lastname: Manuel
authors.forename: Don J
authors.initials: DJ
authors.lastname: Diamond
keywords: B16F10 melanoma; Salmonella; indoleamine 2,3-dioxygenase; polymorphonuclear neutrophils; small hairpin RNA