title: CD8+ T-cell epitope mapping for pneumonia virus of mice in H-2b mice.
abstract: The paramyxovirus pneumonia virus of mice (PVM) is a rodent model of human respiratory syncytial virus (hRSV) pathogenesis. Here we characterized the PVM-specific CD8(+) T-cell repertoire in susceptible C57BL/6 mice. In total, 15 PVM-specific CD8(+) T-cell epitopes restricted by H-2D(b) and/or H-2K(b) were identified. These data open the door for using widely profiled, genetically manipulated C57BL/6 mice to study the contribution of epitope-specific CD8(+) T cells to PVM pathogenesis.
authors.affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA. walsh.kevin@gene.com
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Walsh
authors.forename: John
authors.initials: J
authors.lastname: Sidney
authors.forename: Megan
authors.initials: M
authors.lastname: Welch
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Fremgen
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
authors.forename: Michael B A
authors.initials: MB
authors.lastname: Oldstone
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D018604:Epitope Mapping; D018984:Epitopes, T-Lymphocyte / Q000235:genetics; D006183:H-2 Antigens / Q000378:metabolism; D064532:Histocompatibility Antigen H-2D / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D029122:Murine pneumonia virus / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D018186:Pneumovirus Infections / Q000276:immunology / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D018984:Epitopes, T-Lymphocyte; D006183:H-2 Antigens; C032876:H-2Kb protein, mouse; D064532:Histocompatibility Antigen H-2D; D014764:Viral Proteins; D007371:Interferon-gamma