title: Questioning the costs and benefits of non-invasive prenatal testing.
abstract: Prenatal testing for Down syndrome through the use of non-invasive prenatal testing (NIPT) has been increasingly implemented in clinical practice and a recent cost analysis suggests that NIPT is cost effective when compared to other screening modalities in high risk populations. However, this anaylsis makes many assumptions regarding uptake of testing and pregnancy termination, which cannot be applied to all populations in the United States. Additionally, this cost analysis, which hinges on fewer Down syndrome births, does not align with the goals of prenatal testing to support autonomous and value consistent decisions. NIPT is an expensive new technology and more careful analysis is needed to determine the impact of NIPT on outcomes and overall healthcare costs.
authors.affiliation: Madigan Army Medical Center, Department of Obstetrics and Gynecology, Tacoma , WA , USA.
authors.forename: Katie
authors.initials: K
authors.lastname: Stoll
authors.forename: Monica
authors.initials: M
authors.lastname: Lutgendorf
authors.forename: Dana
authors.initials: D
authors.lastname: Knutzen
authors.forename: Peter E
authors.initials: PE
authors.lastname: Nielsen
mesh_terms: D000328:Adult; D003362:Cost-Benefit Analysis; D004314:Down Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008423:Maternal Age; D048208:Nuchal Translucency Measurement / Q000191:economics; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000191:economics* / Q000706:statistics & numerical data; D014481:United States / Q000453:epidemiology