title: Total synthesis of 3,7-dimethyl-7-hydroxy-2-octen-1,6-olide and 3,7-dimethyl-2,6-octadien-1,6-olide.
abstract: 3,7-Dimethyl-7-hydroxy-2-octen-1,6-olide and 3,7-dimethyl-2,6-octadien-1,6-olide, the natural bioactive compounds isolated from the fruit of Litsea cubeba and the liverwort Plagiochila rutilans, were totally synthesized using easily available cis-geraniol as raw material in short, convenient, and low-cost, five-step reactions including three steps of oxidation, cyclization, and dehydration, with an overall yield of 47.5% and 37.3%.
authors.affiliation: a Department of Applied Chemistry , China Agricultural University , Beijing , 100193 , China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Dong
authors.forename: Ming-Yan
authors.initials: MY
authors.lastname: Yang
authors.forename: Jia-Zheng
authors.initials: JZ
authors.lastname: Jiang
authors.forename: Ming-An
authors.initials: MA
authors.lastname: Wang
mesh_terms: D000080462:Acyclic Monoterpenes; D003500:Cyclization; D005638:Fruit / Q000737:chemistry; D035926:Hepatophyta / Q000737:chemistry*; D032862:Litsea / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C584340:3,7-dimethyl-2,6-octadien-1,6-olide; C584341:3,7-dimethyl-7-hydroxy-2-octen-1,6-olide; D000080462:Acyclic Monoterpenes; D013729:Terpenes; C007836:geraniol