title: Demographic and serological characteristics of Asian Americans with hepatitis B infection diagnosed at community screenings.
abstract: There is limited information regarding follow-up and hepatitis B serological status of Asian Americans diagnosed with chronic hepatitis B (CHB) through community screening. The aims of this study were to evaluate the prevalence and characterize CHB among Asians living in Los Angeles, assess follow-up of individuals with CHB diagnosed at screening and compare with patients with CHB followed by community gastroenterologists. Between October 2007 and May 2010, 7387 Asians were tested for HBV. HBsAg positive individuals (CHB) underwent additional testing for ALT, HBeAg/anti-HBe and HBV DNA. Patients with CHB were contacted 6 months later to determine whether they received follow-up care. We compared serological patterns of these individuals with CHB to patients with CHB who were seen for the first time (treatment naïve) by community gastroenterologists during the study period. Prevalence of CHB was 5.2%. About 99% patients with CHB were foreign-born, and only 27% could read/write English. 297 (77%) patients with CHB could be reached 6 months after diagnosis; 43% did not receive follow-up care, mostly because of lack of medical insurance. Patients with CHB followed by gastroenterologists were more likely to have insurance (69% vs 26%, P < 0.0001). 90% patients with CHB at screening were HBeAg negative/anti-HBe positive with 62% having inactive disease compared to only 30% of patients seen by gastroenterologists (P < 0.0001). Among CHB participants, 13% met criteria for treatment compared to 51% of patients with CHB (P < 0.0001). Only a small number of CHB screening participants require antiviral therapy. Lack of medical insurance is the main reason for most patients with CHB not seeking follow-up care after screening.
authors.affiliation: Asian Pacific Liver Center, Saint Vincent Medical Center, Los Angeles, CA, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Xu
authors.forename: C
authors.initials: C
authors.lastname: Tien
authors.forename: M
authors.initials: M
authors.lastname: Chang
authors.forename: J
authors.initials: J
authors.lastname: Rhee
authors.forename: A
authors.initials: A
authors.lastname: Tien
authors.forename: H S
authors.initials: HS
authors.lastname: Bae
authors.forename: F C-S
authors.initials: FC
authors.lastname: Ho
authors.forename: L S
authors.initials: LS
authors.lastname: Chan
authors.forename: T-L
authors.initials: TL
authors.lastname: Fong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D001213:Asian; D004279:DNA, Viral / Q000097:blood; D003710:Demography; D005260:Female; D005500:Follow-Up Studies; D006297:Health Services Accessibility / Q000706:statistics & numerical data; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D015141:Los Angeles / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015995:Prevalence
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D000410:Alanine Transaminase
keywords: disease surveillance; vaccination