title: Engineering robust polar chiral clathrate crystals.
abstract: The R-(+)-enantiomeric form of Dianin's compound and the S-(+)-enantiomeric form of its direct thiachroman analogue both obtained chromatographically employing a cellulose tris(3,5-dimethylphenylcarbamate) column, are shown to undergo supramolecular assembly to form a polar clathrate lattice which is stable even in the absence of a consolidating guest component.
authors.affiliation: SAFC Pharmorphix®, A Sigma Aldrich Company, 250 Cambridge Science Park, Milton Road, Cambridge, CB4 0WE, UK. chris.frampton@sial.com
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Frampton
authors.forename: Kamal A
authors.initials: KA
authors.lastname: Ketuly
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: James H
authors.initials: JH
authors.lastname: Gall
authors.forename: David D
authors.initials: DD
authors.lastname: Macnicol