title: ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4+T cells by plasmacytoid dendritic cells.
abstract: Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) that infiltrate primary breast tumors impair patient survival. The ICOS-mediated interaction between tumor-infiltrating CD4+T cells and pDCs leads to the amplification of Tregs and interleukin-10 secretion. Importantly, ICOS+cell infiltration correlates with adverse patient prognosis, identifying ICOS as a new target for cancer immunotherapy.
authors.affiliation: Université de Lyon; Lyon, France ; ISPB; Université de Lyon 1; Lyon, France ; INSERM U1052; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; CNRS UMR5286; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; LabEx DEVweCAN; Lyon, France ; Centre Léon Bérard; Lyon, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Faget
authors.forename: Vanja
authors.initials: V
authors.lastname: Sisirak
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Blay
authors.forename: Christophe
authors.initials: C
authors.lastname: Caux
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bendriss-Vermare
authors.forename: Christine
authors.initials: C
authors.lastname: Ménétrier-Caux
keywords: ICOS; breast cancer; immunosuppression; plasmacytoid dendritic cells; regulatory T cells