title: Lipid profile and glycosylated hemoglobin status of gestational diabetic patients and healthy pregnant women.
abstract: OBJECTIVE
  Lipid profile and glycosylated hemoglobin level changes in gestational diabetes. The extent to which this alteration takes place is still not clearly documented.
  
  
  METHODS
  To add a clear answer to this question, lipid profile parameters, and glycosylated hemoglobin status were determined in patients with gestational diabetes mellitus and compared to healthy pregnant women (controls).
  
  
  RESULTS
  Fasting plasma glucose levels, plasma glucose levels 1 hour, and plasma glucose levels 2 hours after 75 gm oral glucose administration (oral glucose tolerance test) were significantly higher in patients with gestational diabetes as compared to controls. Glycosylated hemoglobin was significantly higher in gestational diabetes than in controls. It was observed that there was a significant increase in serum cholesterol and serum triglyceride level in cases with gestational diabetes when compared to healthy pregnant women.
  
  
  CONCLUSIONS
  The results of our study suggest that abnormal glucose levels, glycosylated hemoglobin, serum cholesterol, and serum triglycerides play an important role in pathophysiology of gestational diabetes, and therefore, extensive studies are required. Early diagnosis of gestational diabetes will decrease adverse neonatal and maternal outcomes.
authors.affiliation: Department of Biochemistry, Khyber Girls Medical College, Peshawar, KPK, Pakistan. radhiakhan@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Khan
authors.forename: K
authors.initials: K
authors.lastname: Ali
authors.forename: Z
authors.initials: Z
authors.lastname: Khan
authors.forename: T
authors.initials: T
authors.lastname: Ahmad
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism*; D064368:Healthy Volunteers; D006801:Humans; D007194:India; D008055:Lipids / Q000097:blood*; D011247:Pregnancy
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008055:Lipids