title: [Early diagnosis and therapy in pulmonary hypertension--aspects of a vision].
abstract: In patients with pulmonary hypertension progressive vascular changes in the lung precede the clinical and hemodynamic manifestations of the disease. Therefore, early diagnosis and timely treatment of the disease are crucial. This has been the topic of an expert meeting in Greifswald, Germany in June 2012. The current definition of pulmonary hypertension requires a mean pulmonary artery pressure ≥ 25 mmHg at rest, a hemodynamic abnormality already reflecting pulmonary vascular changes beyond early disease. There is increasing evidence supporting the concept that a lower pressure threshold at rest or an abnormal pressure response with exercise better characterize early disease. While right heart catheterization at rest remains the diagnostic gold standard other methods for detecting early disease are explored with echocardiography being the most frequently used technique. Targeted therapy has been approved for patients with pulmonary arterial hypertension (PAH, WHO-group I) in functional class II-IV. Preliminary data in functional class I patients suggest therapeutic potential of theses drugs in early disease as well. Current guidelines propose therapeutic goals based on parameters with prognostic importance. However, these recommendations are based on mostly retrospective analyses of pre-treatment data obtained in patients with pulmonary hypertension in functional class II-IV. Therefore, evidence-based therapeutic goals for early interventions in functional class I patients are lacking.
authors.affiliation: Universitätsmedizin Greifswald, Klinik für Innere Medizin B, Greifswald, Deutschland. ewert@uni-greifswald.de
authors.forename: R
authors.initials: R
authors.lastname: Ewert
authors.forename: H
authors.initials: H
authors.lastname: Olschewski
authors.forename: H A
authors.initials: HA
authors.lastname: Ghofrani
authors.forename: C F
authors.initials: CF
authors.lastname: Opitz
mesh_terms: D042241:Early Diagnosis; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000517:prevention & control*; D055502:Secondary Prevention / Q000379:methods*