title: Topography-Based Keratoconus Regression.
abstract: OBJECTIVE
  To report 3 cases of keratoconic patients who had progressive corneal topographic flattening during a 2-year follow-up period.
  
  
  METHODS
  Case series.
  
  
  RESULTS
  Three patients with bilateral keratoconus, each operated for advanced keratoconus in one of their eyes, were observed for possible progression of the disorder for a period of 2 years. During the 2-year follow-up period, topographic examination showed progressive corneal flattening in the nonoperated eye. Mean keratometry decreased in all patients, whereas topography showed significant flattening at the apex of the cone. Best-spectacle-corrected visual acuity increased in one of the patients, whereas the others had stable uncorrected and best-spectacle-corrected visual acuity during the follow-up period. All patients had positive family medical history for diabetes mellitus, but none of them was diabetic.
  
  
  CONCLUSIONS
  This is the first report of topography-based keratoconus regression during a 2-year follow-up period.
authors.affiliation: *Vardinoyiannion Eye Institute of Crete, Department of Cornea, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; †Cornea and Refractive Services, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL.
authors.forename: George D
authors.initials: GD
authors.lastname: Kymionis
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Tsoulnaras
authors.forename: Michael A
authors.initials: MA
authors.lastname: Grentzelos
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Shehadeh
authors.forename: Nektarios E
authors.initials: NE
authors.lastname: Klados
authors.forename: Alexandra A
authors.initials: AA
authors.lastname: Karavitaki
authors.forename: Vardhaman P
authors.initials: VP
authors.lastname: Kankariya
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Pallikaris
mesh_terms: D000328:Adult; D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D014792:Visual Acuity / Q000502:physiology