title: Upregulation of microRNA 181c expression in gastric cancer tissues and plasma.
abstract: OBJECTIVE
  To test the microRNA-181c (miR-181c) expression in tissues and plasma of gastric cancer (GC) cases, analyze any correlations, and explore the possibility of miR-181c as a potential molecular marker for GC diagnosis.
  
  
  METHODS
  Relative miR-181c expression levels in cancers and plasma from 30 GC patients was tested using reverse transcription?real-time fluorescent quantitation PCR and compared to that in samples from 30 gastric ulcer and 30 chronic gastritis patients.
  
  
  RESULTS
  The miR-181c expression level in the GC tissues was significantly higher than that in the gastric ulcer and chronic gastritis tissues (P = 0.000), as was the miR-181c expression level in the GC plasma (P = 0.000). We determined that miR-181c expression in GC plasma was positively correlated to its expression in the GC tissues (P = 0.000).
  
  
  CONCLUSIONS
  The expression of miR-181c is upregulated in GC tissues and plasma, and the miR-181c expression level in GC plasma is positively correlated to that in the corresponding cancer tissues. Plasma miR-181c is possibly a new serological marker for GC diagnosis.
authors.affiliation: Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University, Beijing, China. cuimeih@sina.com
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Cui
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Hou
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Lei
authors.forename: Fang-Hong
authors.initials: FH
authors.lastname: Mu
authors.forename: Gui-Bin
authors.initials: GB
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: Yue
authors.forename: Yi
authors.initials: Y
authors.lastname: Fu
authors.forename: Guo-Xing
authors.initials: GX
authors.lastname: Yi
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D005756:Gastritis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood* / Q000235:genetics* / Q000473:pathology; D013276:Stomach Ulcer / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C540193:MIrn181 microRNA, human; D035683:MicroRNAs