title: Specificity and mechanism-of-action of the JAK2 tyrosine kinase inhibitors ruxolitinib and SAR302503 (TG101348).
authors.affiliation: Department of Biochemistry, University of Zürich, Zürich, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Swiss Institute for Experimental Cancer Research, School of Life Sciences, École polytechnique fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Georgeon
authors.affiliation: Brain Mind Institute, School of Life Sciences, École polytechnique fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Moser
authors.affiliation: Brain Mind Institute, School of Life Sciences, École polytechnique fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: D J
authors.initials: DJ
authors.lastname: Moore
authors.affiliation: Department of Biochemistry, University of Zürich, Zürich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Caflisch
authors.affiliation: Swiss Institute for Experimental Cancer Research, School of Life Sciences, École polytechnique fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Hantschel
mesh_terms: D006801:Humans; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology; D000096926:Benzenesulfonamides
chemical_list: D053614:Janus Kinase 2; D047428:Protein Kinase Inhibitors; D011759:Pyrrolidines; D013449:Sulfonamides; C528327:fedratinib; D000096926:Benzenesulfonamides