title: Role of β-adrenergic receptors and nitric oxide signaling in exercise-mediated cardioprotection.
abstract: Exercise promotes cardioprotection in both humans and animals not only by reducing risk factors associated with cardiovascular disease but by reducing myocardial infarction and improving survival following ischemia. This article will define the role that nitric oxide and β-adrenergic receptors play in mediating the cardioprotective effects of exercise in the setting of ischemia-reperfusion injury.
authors.affiliation: Department of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, Georgia, USA. dlefer@emory.edu
authors.forename: John W
authors.initials: JW
authors.lastname: Calvert
authors.forename: David J
authors.initials: DJ
authors.lastname: Lefer
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004285:Dogs; D015444:Exercise / Q000502:physiology*; D006801:Humans; D051379:Mice; D009203:Myocardial Infarction / Q000503:physiopathology / Q000517:prevention & control; D009569:Nitric Oxide / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011943:Receptors, Adrenergic, beta; D009569:Nitric Oxide