title: [Long-term survival of metastatic clear cell adenocarcinoma of the female urethra by multidisciplinary treatment: a case report].
abstract: We report a case of clear cell adenocarcinoma of the female urethra. A 57-year-old woman presented with complaint of gross hematuria. Abdominal ultrasonography, cystourethroscopy, computed tomography (CT) and magnetic resonance imaging (MRI) revealed the urethral tumor was invasive to bladder neck. Clinical stage was determined as cT3N1M0, then anterior pelvic exenteration and ileal conduit formation were performed. The pathological diagnosis was clear cell adenocarcinoma of urethra and the stage was pT3N1. The patient received TS-1 and cisplatin for postoperative recurrence, but she died from multiple lung metastasis 54 months after the operation. Clear cell adenocarcinoma of the female urethra is rare case in the Japanese literatures. Pathogenesis and management of this rare condition are discussed.
authors.affiliation: Department of Urology, Hamamatsu University School of Medicine.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furuse
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kurita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
authors.forename: Keita
authors.initials: K
authors.lastname: Tamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Otsuka
authors.forename: Soichi
authors.initials: S
authors.lastname: Mugiya
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Ozono
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D009367:Neoplasm Staging; D017640:Silicates / Q000008:administration & dosage; D013997:Time Factors; D014025:Titanium / Q000008:administration & dosage; D016896:Treatment Outcome; D014523:Urethral Neoplasms / Q000473:pathology / Q000628:therapy*; D001749:Urinary Bladder Neoplasms / Q000473:pathology; D013520:Urologic Surgical Procedures
chemical_list: D017640:Silicates; C103828:titanium silicide; D014025:Titanium; D002945:Cisplatin