title: High serum HTATIP2/TIP30 level in serous ovarian cancer as prognostic or diagnostic marker.
abstract: BACKGROUND
  Human HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is an evolutionarily conserved gene that is expressed ubiquitously in human tissues and some tumor tissues. This protein has been found to be associated with some gynecological cancers; as such, this study aimed to investigate blood HTATIP2/TIP30 levels in patients with ovarian cancer.
  
  
  METHODS
  Twenty-three women with ovarian cancer and 18 patients with various non-cancerous gynecological complaints (for example, dysfunctional uterine bleeding, fibroids, and urinary incontinence) were included in the study. The pathological diagnosis of ovarian cancer was adenocarcinoma. HTATIP2/TIP30 concentration in the patients' blood samples was determined using ELISA kits.
  
  
  RESULTS
  The HTATIP2/TIP30 level was significantly higher in the cancer group than in the control group (1.84 ± 0.82 versus 0.57 ± 0.13 ng/ml, mean ± SD).
  
  
  CONCLUSIONS
  We demonstrated the potential role of HTATIP2/TIP30 in ovarian cancer for the first time, thereby enlightening future studies targeting HTATIP2/TIP30 in ovarian cancer treatment, diagnosis, and prevention.
authors.affiliation: Department of Obstetrics and Gynecology, Ataturk University, Faculty of Medicine, Erzurum 25240, Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Kumtepe
authors.forename: Zekai
authors.initials: Z
authors.lastname: Halici
authors.forename: Ozlem
authors.initials: O
authors.lastname: Sengul
authors.forename: Celalettin Semih
authors.initials: CS
authors.lastname: Kunak
authors.forename: Yasin
authors.initials: Y
authors.lastname: Bayir
authors.forename: Nergiz
authors.initials: N
authors.lastname: Kilic
authors.forename: Elif
authors.initials: E
authors.lastname: Cadirci
authors.forename: Alparslan
authors.initials: A
authors.lastname: Pulur
authors.forename: Zafer
authors.initials: Z
authors.lastname: Bayraktutan
mesh_terms: D000123:Acetyltransferases / Q000097:blood*; D000230:Adenocarcinoma / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005831:Genital Diseases, Female / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D015658:HIV Infections / Q000378:metabolism / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000378:metabolism / Q000472:pathogenicity; D006801:Humans; D008875:Middle Aged; D058990:Molecular Targeted Therapy; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D014157:Transcription Factors / Q000097:blood*
chemical_list: D014157:Transcription Factors; D000123:Acetyltransferases; C111246:HTATIP2 protein, human