title: Emerging regulation and functions of autophagy.
abstract: Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.
authors.affiliation: Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maetzu 9, 28040 Madrid, Spain. patricia.boya@csic.es
authors.forename: Patricia
authors.initials: P
authors.lastname: Boya
authors.forename: Fulvio
authors.initials: F
authors.lastname: Reggiori
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D001692:Biological Transport; D054884:Host-Pathogen Interactions; D006801:Humans