title: New Labdane-type diterpenoids and anti-inflammatory constituents from Hedychium coronarium.
abstract: Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3-6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.
authors.affiliation: Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@mail.tajen.edu.tw.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Ting
authors.forename: Yi-Chin
authors.initials: YC
authors.lastname: Wu
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Tai-Chi
authors.initials: TC
authors.lastname: Wang
authors.forename: Jinn-Fen
authors.initials: JF
authors.lastname: Chen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry; D006801:Humans; D009504:Neutrophils / Q000187:drug effects; D010196:Pancreatic Elastase; D013481:Superoxides / Q000037:antagonists & inhibitors; D030521:Zingiberaceae
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D013481:Superoxides; D010196:Pancreatic Elastase