title: The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon.
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. michela.rosini@unibo.it
authors.forename: Michela
authors.initials: M
authors.lastname: Rosini
authors.forename: Elena
authors.initials: E
authors.lastname: Simoni
authors.forename: Manuela
authors.initials: M
authors.lastname: Bartolini
authors.forename: Elena
authors.initials: E
authors.lastname: Soriano
authors.forename: José
authors.initials: J
authors.lastname: Marco-Contelles
authors.forename: Vincenza
authors.initials: V
authors.lastname: Andrisano
authors.forename: Barbara
authors.initials: B
authors.lastname: Monti
authors.forename: Manfred
authors.initials: M
authors.lastname: Windisch
authors.forename: Birgit
authors.initials: B
authors.lastname: Hutter-Paier
authors.forename: David W
authors.initials: DW
authors.lastname: McClymont
authors.forename: Ian R
authors.initials: IR
authors.lastname: Mellor
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Bolognesi
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001665:Binding Sites; D002645:Chickens; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D008024:Ligands; D062105:Molecular Docking Simulation; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000378:metabolism; D017434:Protein Structure, Tertiary; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry / Q000378:metabolism; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D002800:Cholinesterase Inhibitors; D007211:Indoles; D008024:Ligands; D010446:Peptide Fragments; D016194:Receptors, N-Methyl-D-Aspartate; D011994:Recombinant Proteins; C075222:amyloid beta-protein (1-42); D000110:Acetylcholinesterase; C010119:latrepirdine
keywords: Alzheimer’s disease; NMDA receptors; acetylcholinesterase; amyloid aggregation; butyrylcholinesterase; dual binding inhibitors