title: Hypocellular/lymphohistiocytic variant of Anaplastic Large Cell Lymphoma of lymph node, mimicking granulation tissue.
abstract: Anaplastic Large Cell Lymphoma (ALCL) is a subgroup of T/null cell non-Hodgkin lymphoma (NHL) in WHO classification. Lymphohistiocytic (LH) variant constitutes about 10% of all ALCLs and characterized by presence of abundant reactive histiocytes that can mask the neoplastic nature of the lesion, leading to misdiagnose as "reactive lymphadenopathy". Here we introduce a 16-year-old female patient, diagnosed as hypocellular LH variant ALCL with unusual histologic feature including granulation tissue- like appearance. We emphasize that in young patients with unusual- looking reactive lymphadenopathy, ALCL should be considered as one of differential diagnoses. A brief review of the nature of the lesion and differential diagnoses is also included.
authors.affiliation: Department of Pathology, Shariati Hopital, Tehran University of Medical Sciences, Tehran, Iran. faridkosari@yahoo.com
authors.forename: Farid
authors.initials: F
authors.lastname: Kosari
authors.forename: Hiva
authors.initials: H
authors.lastname: Saffar
authors.forename: Babak
authors.initials: B
authors.lastname: Izadi
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D006097:Granulation Tissue / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology*