title: Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity.
abstract: The Vδ2 and non-Vδ2 (mainly Vδ1) subsets of human γδ T cells have distinct homing patterns and recognize different types of ligands, yet both exert potent antitumor effects. While the T-cell receptor of Vδ2 T cells primarily recognizes tumor cell-derived pyrophosphates, non-Vδ2 γδ T cells preferentially recognize stress-associated surface antigens. Here, we discuss the pros and cons of Vδ2 versus non-Vδ2 γδ T cells as tools for future immunotherapeutic interventions against cancer.
authors.affiliation: Institute of Immunology; University of Kiel; Kiel, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Kabelitz
authors.forename: Shirin
authors.initials: S
authors.lastname: Kalyan
authors.forename: Hans-Heinrich
authors.initials: HH
authors.lastname: Oberg
authors.forename: Daniela
authors.initials: D
authors.lastname: Wesch
keywords: Vδ1 T cells; Vδ2 T cells; cancer immunosurveillance; cytotoxicity; γδ T cells