title: RNAi functionalized scaffold for scarless skin regeneration.
abstract: Combination of a 3-D scaffold with the emerging RNA interference (RNAi) technique represents the latest paradigm of regenerative medicine. In our recent paper "RNAi functionalized collagen-chitosan/silicone membrane bilayer dermal equivalent for full-thickness skin regeneration with inhibited scarring" in the journal Biomaterial, we not only demonstrated a 3-D system for siRNA sustained delivery, but also presented a comprehensive in vivo study by targeting a vital problem in skin regeneration: scarring. It is expected that further development of this kind of RNAi functionalized scaffold can provide a better platform for directing cell fates by integrating the "down-regulating" biomolecular cues into the cellular microenvironment, leading to the complete functional regeneration of skin.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, P.R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.forename: Lie
authors.initials: L
authors.lastname: Ma
authors.forename: Changyou
authors.initials: C
authors.lastname: Gao
mesh_terms: D000818:Animals; D048271:Chitosan / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology*; D020405:Dermis / Q000187:drug effects*; D006801:Humans; D008051:Lipid Bilayers / Q000494:pharmacology*; D034622:RNA Interference; D012038:Regeneration / Q000187:drug effects*; D012828:Silicones / Q000494:pharmacology*
chemical_list: D008051:Lipid Bilayers; D012828:Silicones; D003094:Collagen; D048271:Chitosan
keywords: RNA interference; regenerative medicine; scaffold; scarring; skin