title: One-dimensional surface-imprinted polymeric nanotubes for specific biorecognition by initiated chemical vapor deposition (iCVD).
abstract: Molecular imprinting is a powerful, generic, and cost-effective technique; however, challenges still remain related to the fabrication and development of these systems involving nonhomogeneous binding sites, insufficient template removing, incompatibility with aqueous media, low rebinding capacity, and slow mass transfer. The vapor-phase deposition of polymers is a unique technique because of the conformal nature of coating and offers new possibilities in a number of applications including sensors, microfluidics, coating, and bioaffinity platforms. Herein, we demonstrated a simple but versatile concept to generate one-dimensional surface-imprinted polymeric nanotubes within anodic aluminum oxide (AAO) membranes based on initiated chemical vapor deposition (iCVD) technique for biorecognition of immunoglobulin G (IgG). It is reported that the fabricated surface-imprinted nanotubes showed high binding capacity and significant specific recognition ability toward target molecules compared with the nonimprinted forms. Given its simplicity and universality, the iCVD method can offer new possibilities in the field of molecular imprinting.
authors.affiliation: Faculty of Engineering and Natural Sciences, Sabanci University, 34956 Istanbul, Turkey. gozdeince@sabanciuniv.edu
authors.forename: Gozde Ozaydin
authors.initials: GO
authors.lastname: Ince
authors.forename: Efe
authors.initials: E
authors.lastname: Armagan
authors.forename: Hakan
authors.initials: H
authors.lastname: Erdogan
authors.forename: Fatih
authors.initials: F
authors.lastname: Buyukserin
authors.forename: Lokman
authors.initials: L
authors.lastname: Uzun
authors.forename: Gokhan
authors.initials: G
authors.lastname: Demirel
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D005740:Gases / Q000737:chemistry*; D007074:Immunoglobulin G / Q000032:analysis / Q000737:chemistry; D054802:Molecular Imprinting; D043942:Nanotubes / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D005740:Gases; D007074:Immunoglobulin G; D011108:Polymers; D016650:Fluorescein-5-isothiocyanate; D000537:Aluminum Oxide