title: Elevated serotonin and 5-HIAA in the brainstem and lower serotonin turnover in the prefrontal cortex of suicides.
abstract: Using high pressure liquid chromatography, we find more brainstem 5-HT and 5-HIAA in suicides compared with nonpsychiatric, sudden death controls throughout the rostrocaudal extent of the brainstem DRN and MRN. This suggests that 5-HT synthesis in suicides is greater within all DRN subnuclei and the MRN compared with controls.
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York.
authors.forename: Helene
authors.initials: H
authors.lastname: Bach
authors.forename: Yung-Yu
authors.initials: YY
authors.lastname: Huang
authors.forename: Mark D
authors.initials: MD
authors.lastname: Underwood
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dwork
authors.forename: J John
authors.initials: JJ
authors.lastname: Mann
authors.forename: Victoria
authors.initials: V
authors.lastname: Arango
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001933:Brain Stem / Q000378:metabolism*; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D017397:Prefrontal Cortex / Q000378:metabolism*; D011903:Raphe Nuclei / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013405:Suicide; D055815:Young Adult
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid
keywords: 5-HIAA; brainstem; prefrontal cortex; raphe; serotonin; suicide