title: The Cinderella effect: searching for the best fit between mouse models and human diseases.
abstract: A recent publication questions the suitability of mice as a model for the human inflammatory response and has fueled the continuing debate about the suitability of mice as models for human disease. We discuss recent advances in disease modeling using mice, and the genetic factors that need to be considered when trying to recapitulate aspects of human disease. Failure to appreciate the important differences between human and mouse biology and genetics underlying attempts to generate faithful models frequently leads to poor outcomes. Closely coordinated human and model organism studies are essential to provide traction for translational research.
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine, USA. Electronic address: john.sundberg@jax.org.
authors.forename: John P
authors.initials: JP
authors.lastname: Sundberg
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine, USA.
authors.forename: Derry C
authors.initials: DC
authors.lastname: Roopenian
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine, USA.
authors.forename: Edison T
authors.initials: ET
authors.lastname: Liu
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine, USA; Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK.
authors.forename: Paul N
authors.initials: PN
authors.lastname: Schofield
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D012871:Skin Diseases; D013045:Species Specificity; D057170:Translational Research, Biomedical / Q000379:methods*