title: Evaluation of relative efficacy of β-tricalcium phosphate with and without type I resorbable collagen membrane in periodontal infrabony defects: a clinical and radiographic study.
abstract: OBJECTIVE
  To compare clinically and radiographically, the regenerative potential of a β-tricalcium phosphate bone graft, Cerasorb(®) with and without a bioresorbable type I collagen membrane, BioMend Extend™, in treating periodontal infrabony osseous defects.
  
  
  METHODS
  A total of 20 sites from 10 patients showing bilateral infrabony defects were selected and selected sites were randomly divided into experimental site A (Cerasorb(®)) and experimental site B (Cerasorb(®) and BioMend Extend™) by using split mouth design. The clinical parameters like plaque index, gingival index, probing pocket depth, clinical attachment level and gingival recession were recorded at baseline, 6 weeks, 3, 6 and 9 months. Radiographic evaluation (Linear CADIA) at 6 and 9 months; and intrasurgical measurements at baseline and 9 months were carried out to evaluate the defect fill, change in alveolar crest height and defect resolution.
  
  
  RESULTS
  Significant reduction in all clinical parameters was observed in both the groups. On comparison no statistical significance was observed between the two groups. Radiographically, in site A there was significant defect fill of 78.4 and 97.2% at 6 and 9 months respectively. Whereas in site B reduction was 78.4 and 97.2% at 6 and 9 months respectively. After surgical re-entry, there was significant defect fill of 89.2 and 74% in both groups.
  
  
  CONCLUSIONS
  Individually both the graft and membrane have shown promising results in the management of periodontal intrabony defects. But the added benefit by combining Cerasorb(®) with BioMend Extend™ was not observed statistically in both clinical radiographic findings.
authors.affiliation: Department of Periodontics, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India. dentalcys@gmail.com
authors.forename: D Trinath
authors.initials: DT
authors.lastname: Kishore
authors.forename: Tushar
authors.initials: T
authors.lastname: Bandiwadekar
authors.forename: R
authors.initials: R
authors.lastname: Padma
authors.forename: Surangama
authors.initials: S
authors.lastname: Debunath
authors.lastname: Profulla
authors.forename: Ajay
authors.initials: A
authors.lastname: Reddy
mesh_terms: D020341:Absorbable Implants; D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000473:pathology; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000000981:diagnostic imaging / Q000601:surgery; D024042:Collagen Type I; D003774:Dental Plaque Index; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D011859:Radiography; D013524:Surgical Flaps / Q000601:surgery; D019237:Tooth Cervix / Q000000981:diagnostic imaging / Q000473:pathology; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D024042:Collagen Type I; D008567:Membranes, Artificial; C485817:beta-tricalcium phosphate