title: Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitination.
abstract: The post-translational modification of intracellular proteins by O-linked N-acetylglucosamine (O-GlcNAc) regulates essential cellular processes such as signal transduction, transcription, translation, and protein degradation. Misfolded, damaged, and unwanted proteins are tagged with a chain of ubiquitin moieties for degradation by the proteasome, which is critical for cellular homeostasis. In this review, we summarize the current knowledge of the interplay between O-GlcNAcylation and ubiquitination in the control of protein degradation. Understanding the mechanisms of action of O-GlcNAcylation in the ubiquitin-proteosome system shall facilitate the development of therapeutics for human diseases such as cancer, metabolic syndrome, and neurodegenerative diseases.
authors.affiliation: Program in Integrative Cell Signaling and Neurobiology of Metabolism and Section of Comparative Medicine, Department of Cellular & Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520;
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Ruan
authors.forename: Yongzhan
authors.initials: Y
authors.lastname: Nie
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Yang
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism*; D000215:Acylation; D005786:Gene Expression Regulation; D006801:Humans; D058977:Molecular Sequence Annotation; D010766:Phosphorylation; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism*; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D059748:Proteolysis; D015398:Signal Transduction / Q000235:genetics*; D014158:Transcription, Genetic; D054875:Ubiquitination; D014452:Ubiquitins / Q000235:genetics / Q000378:metabolism*
chemical_list: D014452:Ubiquitins; D046988:Proteasome Endopeptidase Complex; D000117:Acetylglucosamine