title: Long-term bony integration and resorption kinetics of a xenogeneic bone substitute after sinus floor augmentation: histomorphometric analyses of human biopsy specimens.
abstract: In this case series, a systematic histomorphometric analysis of two human bone biopsy specimens was conducted 1 and 5 years after grafting with a xenogeneic bovine bone substitute material (BSM). While the 1-year specimen still showed extensive signs of an active desmal ossification, the specimen after 5 years mainly showed mature lamellar bone without bone turnover or remodeling. A completed bony integration without extensive resorption of the BSM particles could be detected. Altogether, a good integration in the bone with osteoconduction and a high biocompatibility was seen.
authors.affiliation: Department of Oral, Maxillofacial and Plastic Surgery, University Medical Centre of the Johannes Gutenberg-University Mainz, Germany. marcusoklein@me.com
authors.forename: Marcus O
authors.initials: MO
authors.lastname: Klein
authors.forename: Peer W
authors.initials: PW
authors.lastname: Kämmerer
authors.forename: Hermann
authors.initials: H
authors.lastname: Götz
authors.forename: Heinz
authors.initials: H
authors.lastname: Duschner
authors.forename: Wilfried
authors.initials: W
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000818:Animals; D001706:Biopsy / Q000379:methods; D001857:Bone Matrix / Q000473:pathology; D001861:Bone Regeneration / Q000502:physiology; D001862:Bone Resorption / Q000503:physiopathology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000145:classification*; D002417:Cattle; D003094:Collagen; D003758:Dental Implantation, Endosseous / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D064593:Heterografts / Q000473:pathology / Q000637:transplantation*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008137:Longitudinal Studies; D008297:Male; D008437:Maxilla / Q000473:pathology* / Q000601:surgery; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D016348:Osseointegration / Q000502:physiology*; D010011:Osteocytes / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D059546:Sinus Floor Augmentation / Q000379:methods*; D055114:X-Ray Microtomography / Q000379:methods
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen