title: Oral administration of chitin and chitosan prevents peanut-induced anaphylaxis in a murine food allergy model.
abstract: Peanut allergy is IgE-mediated type-I hypersensitivity, and T helper 2 cytokines are central to those pathogenesis. We investigated the effects of the administration of chitin and chitosan on peanut-induced hypersensitivities in mouse food allergy models. Chitin and chitosan protected mice against peanut-induced anaphylaxis reactions, and the peanut-specific IgE production decreased by up to 47% with the administration of β-chitosan. The levels of IL-5, IL-13, and IL-10 were significantly suppressed in all groups (α-chitin≥β-chitin≥β-chitosan). These results suggested that the administration of chitin and chitosan from by-products of food processing are beneficial for the prevention of food allergies.
authors.affiliation: Division of Metabolism & Functionality Research, Korea Food Research Institute, 1201-62, Anyangpangyo-ro, Bundang-gu, Seognam-si, Kyeonggi-do 463-746, Republic of Korea.
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Bae
authors.forename: Hee Soon
authors.initials: HS
authors.lastname: Shin
authors.forename: En-Kyoung
authors.initials: EK
authors.lastname: Kim
authors.forename: Jaeheung
authors.initials: J
authors.lastname: Kim
authors.forename: Dong-Hwa
authors.initials: DH
authors.lastname: Shon
mesh_terms: D000284:Administration, Oral; D000707:Anaphylaxis / Q000276:immunology / Q000517:prevention & control*; D000818:Animals; D010367:Arachis / Q000009:adverse effects / Q000276:immunology; D002686:Chitin / Q000008:administration & dosage* / Q000737:chemistry; D048271:Chitosan / Q000008:administration & dosage* / Q000737:chemistry; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D005260:Female; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D051379:Mice; D021183:Peanut Hypersensitivity / Q000276:immunology / Q000517:prevention & control*; D013154:Spleen / Q000166:cytology / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D002686:Chitin; D007073:Immunoglobulin E; D048271:Chitosan
keywords: APC; Ag; CPE; CT; Chitin; Chitosan; DMSO; ELISA; GWP; HRP; IFN; IL; Ig; IgE suppression; Peanut allergy; T-helper; Th; Th2 inhibition; antigen; antigen-presenting cells; cholera toxin; crude peanut extract; dimethyl sulfoxide; enzyme-linked immunosorbent assay; ground whole peanut; horseradish peroxidase; immunoglobulin; interferon; interleukin; mAb; monoclonal antibodies