title: Between-site reliability of startle prepulse inhibition across two early psychosis consortia.
abstract: Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; however, between-site stability has not been established. In two separate consortia investigating biomarkers of early psychosis, traveling participants studies were carried out as a part of quality assurance procedures to assess the fidelity of data across sites. In the North American Prodromal Longitudinal Studies (NAPLS) consortium, eight normal participants traveled to each of the eight NAPLS sites and were tested twice at each site on the startle PPI paradigm. In preparation for a binational study, 10 healthy participants were assessed twice in both San Diego and Mexico City. Intraclass correlations between and within sites were significant for PPI and startle response parameters, confirming the reliability of startle measures across sites in both consortia. There were between-site differences in startle magnitude in the NAPLS study that did not appear to be related to methods or equipment. In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites.
authors.affiliation: Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0810, USA. kcadenhead@ucsd.edu
authors.forename: Kristin S
authors.initials: KS
authors.lastname: Cadenhead
authors.forename: Jean
authors.initials: J
authors.lastname: Addington
authors.forename: Tyrone D
authors.initials: TD
authors.lastname: Cannon
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Cornblatt
authors.forename: Camilo
authors.initials: C
authors.lastname: de la Fuente-Sandoval
authors.forename: Dan H
authors.initials: DH
authors.lastname: Mathalon
authors.forename: Diana O
authors.initials: DO
authors.lastname: Perkins
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Seidman
authors.forename: Ming
authors.initials: M
authors.lastname: Tsuang
authors.forename: Elaine F
authors.initials: EF
authors.lastname: Walker
authors.forename: Scott W
authors.initials: SW
authors.lastname: Woods
authors.forename: Peter
authors.initials: P
authors.lastname: Bachman
authors.forename: Ayse
authors.initials: A
authors.lastname: Belger
authors.forename: Ricardo E
authors.initials: RE
authors.lastname: Carrión
authors.forename: Franc C L
authors.initials: FC
authors.lastname: Donkers
authors.forename: Erica
authors.initials: E
authors.lastname: Duncan
authors.forename: Jason
authors.initials: J
authors.lastname: Johannesen
authors.forename: Pablo
authors.initials: P
authors.lastname: León-Ortiz
authors.forename: Gregory
authors.initials: G
authors.lastname: Light
authors.forename: Alejandra
authors.initials: A
authors.lastname: Mondragón
authors.forename: Margaret
authors.initials: M
authors.lastname: Niznikiewicz
authors.forename: Jason
authors.initials: J
authors.lastname: Nunag
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Roach
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Solís-Vivanco
mesh_terms: D000328:Adult; D005260:Female; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000503:physiopathology*; D013216:Reflex, Startle / Q000502:physiology*; D055815:Young Adult