title: Survival and morbidity among two cohorts of extremely low birth weight neonates from a tertiary hospital in northern India.
abstract: This study was conducted to compare the survival and morbidity of extremely low birth weight neonates born during two different time periods (2009-10 and 2001-02) at a Level III referral neonatal unit in Northern India. All consecutive intramural extremely low birth weight neonates (<1000g), irrespective of gestation, and admitted to Intensive Care were enrolled. 149 and 123 neonates were enrolled during 2009-10 and 2001-02, respectively. The baseline characteristics were comparable except for mean birth weight, which was lower during 2009-10 (843±108g vs 885±126g, P=0.003). Surfactant therapy (54% vs 18%, P<0.001), non-invasive ventilation (28% vs 6%, P<0.001), high frequency ventilation (24% vs 4%, P=0.001), IVH (52% vs 25%, P<0.001) and PDA (34% vs 18%, P=0.004) were significantly more during 2009-10. Culture positive sepsis (33% vs 51%, P=0.003) and ROP rates (7% vs 23%, P=0.042) were significantly higher during 2001-02. Overall survival was similar; however, neonates between 28-30 weeks gestation had better survival (63%) during 2009-10 compared to 2001-02 (38%), P=0.009. Survival in neonates 28-30 weeks improved during this period while overall survival remained the same.
authors.affiliation: Neonatal Unit, Department of Pediatrics; and *Department of Ophthalmology; Postgraduate Institute of Medical Education and Research, Chandigarh, India. Correspondence to: Dr Kanya Mukhopadhyay, Additional Professor, Department of Pediatrics, PGIMER, Chandigarh 160 012, India. kanyapupul@yahoo.com.
authors.forename: Kanya
authors.initials: K
authors.lastname: Mukhopadhyay
authors.forename: Deepak
authors.initials: D
authors.lastname: Louis
authors.forename: Srinivas
authors.initials: S
authors.lastname: Murki
authors.forename: Rama
authors.initials: R
authors.lastname: Mahajan
authors.forename: M R
authors.initials: MR
authors.lastname: Dogra
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar
mesh_terms: D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007194:India / Q000453:epidemiology; D007226:Infant Mortality; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D009017:Morbidity; D016019:Survival Analysis; D062606:Tertiary Care Centers