title: Beer and beer compounds: physiological effects on skin health.
abstract: Beer is one of the earliest human inventions and globally the most consumed alcoholic beverage in terms of volume. In addition to water, the 'German Beer Purity Law', based on the Bavarian Beer Purity Law from 1516, allows only barley, hops, yeasts and water for beer brewing. The extracts of these ingredients, especially the hops, contain an abundance of polyphenols such as kaempferol, quercetin, tyrosol, ferulic acid, xanthohumol/isoxanthohumol/8-prenylnaringenin, α-bitter acids like humulone and β-bitter acids like lupulone. 8-prenylnaringenin is the most potent phytoestrogen known to date. These compounds have been shown to possess various anti-bacterial, anti-inflammatory, anti-oxidative, anti-angiogenic, anti-melanogenic, anti-osteoporotic and anti-carcinogenic effects. Epidemiological studies on the association between beer drinking and skin disease are limited while direct evidence of beer compounds in clinical application is lacking. Potential uses of these substances in dermatology may include treatment of atopic eczema, contact dermatitis, pigmentary disorders, skin infections, skin ageing, skin cancers and photoprotections, which require an optimization of the biostability and topical delivery of these compounds. Further studies are needed to determine the bioavailability of these compounds and their possible beneficial health effects when taken by moderate beer consumption.
authors.affiliation: Department of Dermatology and Allergy Biederstein, Technische Universität München, Christine Kühne Center for Allergy Research and Education (CK CARE), Munich, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.affiliation: Brewing and Beverage Technology, Department of Life Science Engineering, Center of Life and Food Sciences Weihenstephan, Technische Universitaet Muenchen, Freising, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Becker
authors.affiliation: Brewing and Beverage Technology, Department of Life Science Engineering, Center of Life and Food Sciences Weihenstephan, Technische Universitaet Muenchen, Freising, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Qian
authors.affiliation: Department of Dermatology and Allergy Biederstein, Technische Universität München, Christine Kühne Center for Allergy Research and Education (CK CARE), Munich, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Ring
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001515:Beer; D003373:Coumaric Acids / Q000494:pharmacology / Q000627:therapeutic use; D053138:Cyclohexenes / Q000494:pharmacology / Q000627:therapeutic use; D044950:Flavanones / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D044949:Kaempferols / Q000494:pharmacology / Q000627:therapeutic use; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D048789:Phytoestrogens / Q000494:pharmacology / Q000627:therapeutic use; D011427:Propiophenones / Q000494:pharmacology / Q000627:therapeutic use; D011794:Quercetin / Q000494:pharmacology / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000188:drug therapy*; D013729:Terpenes / Q000494:pharmacology / Q000627:therapeutic use; D044004:Xanthones / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C119737:8-prenylnaringenin; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D003373:Coumaric Acids; D053138:Cyclohexenes; D044950:Flavanones; D005419:Flavonoids; D044949:Kaempferols; D048789:Phytoestrogens; D011427:Propiophenones; D013729:Terpenes; D044004:Xanthones; C512910:isoxanthohumol; C011867:4-hydroxyphenylethanol; C006552:kaempferol; D011794:Quercetin; C004999:ferulic acid; C008299:lupulon; C007966:humulon; D010626:Phenylethyl Alcohol; C104536:xanthohumol