title: [Comparative study of the hemato-protective effect of Dicarbamine and Leykostime in experimental radiation damage to the blood system].
abstract: There was studied the influence Dicarbamine and Leykostime on peripheral blood leukocyte composition of rabbits in experimental radiogenic damage to the blood system. Dicarbamine significantly insured the safety of circulating red blood cells, prevented the development of severe postradiation thrombocytopenia, reduced postradiation leukocytopenia, and accelerated the recovery of peripheral blood leukocytes to the initial level by segmented neutrophils and lymphocytes. Leukostime ensured the safety of peripheral blood leukocytes however was less effective than Dicarbamine to prevent postradiation deficit of circulating red blood cells and thrombocytes.
authors.forename: I Ia
authors.initials: IIa
authors.lastname: Moiseeva
authors.forename: A I
authors.initials: AI
authors.lastname: Zinov'ev
authors.forename: L V
authors.initials: LV
authors.lastname: Ionicheva
authors.forename: S A
authors.initials: SA
authors.lastname: Nikishin
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000528:radiation effects; D002208:Caproates; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects* / Q000528:radiation effects*; D007970:Leukopenia / Q000209:etiology / Q000517:prevention & control*; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D013921:Thrombocytopenia / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002208:Caproates; D007093:Imidazoles; D011837:Radiation-Protective Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C539419:pentanedioic acid imidazolyl ethanamide; D000069585:Filgrastim