title: [Comparison of the effects of glutamate antibodies on neuronal activity of caspase 3 and memory impairment in rats induced by injection of Abeta(25-35) into the Meynert nuclei].
abstract: In experiments on rats showed that intranasal administration of glutamate antibodies in a dose of 300 microg/kg after 1 h after bilateral injection of neurotoxic fragment of beta-amyloid protein (25-35)--Abeta(25-35)--into the Meynert nuclei restores learning ability in the test of passive avoidance on 3 and 14 days of the experiment. Antibodies to glutamate decrease significantly increasing caspase 3 activity, detected on Day 3 after injection of Abeta(25-35), in samples of the prefrontal cortex and hippocampus but not hypothalamus. Intranasal administration of gamma-globulin had no effect on the performance of violations of mnestic functions and caspase 3 activity.
authors.affiliation: Research Center of Neurology, RAMS, Moscow, Russia
authors.forename: V V
authors.initials: VV
authors.lastname: Kolobov
authors.forename: V G
authors.initials: VG
authors.lastname: Fomina
authors.forename: V Yu
authors.initials: VY
authors.lastname: Gorbatov
authors.forename: T V
authors.initials: TV
authors.lastname: Davydova
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D020532:Basal Nucleus of Meynert / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology; D053148:Caspase 3 / Q000378:metabolism*; D018698:Glutamic Acid / Q000276:immunology*; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D010446:Peptide Fragments / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D005719:gamma-Globulins / Q000494:pharmacology
chemical_list: D016229:Amyloid beta-Peptides; D000906:Antibodies; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35); D005719:gamma-Globulins; D018698:Glutamic Acid; D053148:Caspase 3