title: Iron (FeSo4) bioavailability in obese subjects submitted to bariatric surgery.
abstract: BACKGROUND
  Iron bioavailability in obese subjects after the ingestion of a nutritional supplement was the aim of this work.
  
  
  METHODS
  Fourteen persons were studied before and after bariatric surgery after the ingestion of a nutritional formulation containing 25 mg iron, 25 g fiber and 800 mg calcium.
  
  
  RESULTS
  The following ferremia values (median and minimum--maximum) were obtained before and after bariatric surgery, respectively: Fasting, 105 (70 - 364) μg/dL and 198 (38 - 617) μg/dL; 1 hour, 103 (63 - 305) μg/dL and 160 (11 - 207) μg/dL; 2 hours, 103 (62 - 150) μg/dL and 141 (10 - 412) μg/dL; 3 hours. 97 (63 - 190) μg/dL and 153 (6 - 270) μg/dL; 4 hours, 91 (58 - 163) μg/dL and 156 (40 - 251) μg/dL (p>0.05), with no association of serum iron levels with time. There was a difference in total triglycerides (95 ± 29 mg/dL and 60 ± 10 mg/dL) which were correlated with a decrease in serum ferritin levels (r = 0,926, p = 0.008), UIBC (r = 0.910, p = 0.01), total cholesterol (r = 0,918, p = 0.01) and LDL-c fraction (r = 0.830, p = 0.04), with an increase in HDL-c fraction (r = 0,807, p = 0.05).
  
  
  CONCLUSIONS
  Iron bioavailability in obese subjects was affected by the ingestion of the nutritional formulation containing calcium and fiber, a fact that may cause these patients to develop iron deficiency.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Bueno
authors.forename: Juliana C
authors.initials: JC
authors.lastname: Pizzo
authors.forename: Julio Sergio
authors.initials: JS
authors.lastname: Marchini
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Dutra-de-Oliveira
authors.forename: José Ernesto
authors.initials: JE
authors.lastname: Dos Santos
authors.forename: Fernando
authors.initials: F
authors.lastname: Barbosa Junior
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D019540:Area Under Curve; D050110:Bariatric Surgery; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D019587:Dietary Supplements; D005260:Female; D005290:Ferric Compounds / Q000493:pharmacokinetics*; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000601:surgery*; D011184:Postoperative Period; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D005290:Ferric Compounds; D014280:Triglycerides; C024823:ferric sulfate; D005293:Ferritins; D007501:Iron