title: Influence of polymorphisms in ERCC5, XPA and MTR DNA repair and synthesis genes in B-cell lymphoma risk. A case-control study in Spanish population.
abstract: OBJECTIVE
  Functions pertaining to DNA repair and synthesis are believed to play a critical role in cancer development and seem to be affected by genetic polymorphisms. Herein we performed a case-control study evaluating the influence of three single nucleotide polymorphisms (SNPs) in XPA, ERCC5 and MTR [rs1800975 (G-4A), rs17655 (Asp1104His) and rs1805087 (A2756G), respectively] in lymphoma risk.
  
  
  METHODS
  Genotype distributions were studied in 213 lymphoma Caucasian patients (193 non-Hodgkin/NHL and 20 Hodgkin lymphoma/HL) and 214 controls, residents in a region of Southeast Spain.
  
  
  RESULTS
  No significant differences were observed in the genotype distributions between cases and controls for the studied SNPs. This lack of association was also observed when stratifying for gender or lymphoma type.
  
  
  CONCLUSIONS
  Our results suggest that the rs1800975, rs17655 and rs1805087 SNPs in DNA repair and synthesis of genes do not seem to play a major role in lymphoma susceptibility.
authors.affiliation: Molecular Pathology and Pharmacogenetic Group. Pathology Department, Santa Lucia General University Hospital (HGUSL), Cartagena, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-Cosano
authors.forename: D
authors.initials: D
authors.lastname: Torres-Moreno
authors.forename: P
authors.initials: P
authors.lastname: Conesa-Zamora
mesh_terms: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004260:DNA Repair; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016393:Lymphoma, B-Cell / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013030:Spain; D014157:Transcription Factors / Q000235:genetics*; D051760:Xeroderma Pigmentosum Group A Protein / Q000235:genetics*; D000099250:DNA Excision Repair Protein ERCC-5
chemical_list: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D004268:DNA-Binding Proteins; D004720:Endonucleases; D009687:Nuclear Proteins; D014157:Transcription Factors; D051760:Xeroderma Pigmentosum Group A Protein; D000099250:DNA Excision Repair Protein ERCC-5; C497314:XPA protein, human