title: Deep vein thrombosis and pulmonary embolism after spine surgery: incidence and patient risk factors.
abstract: Anticoagulation after spine surgery confers the unique risk of epidural hematoma. We sought to determine the incidence of and patient risk factors for deep vein thrombosis (DVT) and pulmonary embolism (PE) after spine surgery. We retrospectively reviewed the charts of 1485 patients who had spine surgery at a single tertiary-care center between 2002 and 2009. DVT and PE incidence were recorded along with pertinent patient history information. Univariate and multivariate analyses were performed on the data. VTE incidence was 1.1% (DVTs, 0.7%; PEs, 0.4%). Univariate analysis demonstrated that VTEs had 9 positive risk factors: active malignancy, prior DVT or PE, estrogen replacement therapy, discharge to a rehabilitation facility, hypertension, major depressive disorder, renal disease, congestive heart failure, and benign prostatic hyperplasia (P<.05). Multivariate analysis demonstrated 4 independent risk factors: prior DVT or PE, estrogen replacement therapy, discharge to a rehabilitation facility, and major depressive disorder (P>.05). Surgeons with an improved understanding of VTE after spine surgery can balance the risks and benefits of postoperative anticoagulation.
authors.affiliation: Department of Orthopaedic Surgery, George Washington University, Washington, DC 20037, USA. leahmschulte@gmail.com
authors.forename: Leah M
authors.initials: LM
authors.lastname: Schulte
authors.forename: Joseph R
authors.initials: JR
authors.lastname: O'Brien
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Bean
authors.forename: Todd P
authors.initials: TP
authors.lastname: Pierce
authors.forename: Warren D
authors.initials: WD
authors.lastname: Yu
authors.forename: Clifton
authors.initials: C
authors.lastname: Meals
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001178:Arthroplasty; D006801:Humans; D015994:Incidence; D058498:Kyphoplasty; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology*; D011655:Pulmonary Embolism / Q000453:epidemiology* / Q000517:prevention & control; D012189:Retrospective Studies; D012307:Risk Factors; D013123:Spinal Fusion / Q000379:methods; D013131:Spine / Q000601:surgery; D020246:Venous Thrombosis / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D000925:Anticoagulants