title: Tuning the aggregation behaviour of single-chain bolaphospholipids in aqueous suspension: from nanoparticles to nanofibres to lamellar phases.
abstract: The aggregation behaviour in aqueous suspensions of symmetrical bipolar phospholipids (bolalipids) composed of one long alkyl chain and two polar headgroups were studied as a function of their chemical structure, i.e. the length of their chain, the modification of the chain by introduction of hetero-atoms, triple bonds, or phenyl rings, and the size of the headgroups. Three types of aggregate structures are formed by these bolalipids, namely helical nanofibres, micelle-like aggregates and lamellar sheets. The type of aggregate formed depends not only on the chemical structure, particularly the ratio of the cross-sectional area of the headgroup and the chain, but also on the presence of attractive interactions via hydrogen bonds or repulsive electrostatic interactions between the headgroups.
authors.affiliation: Institute of Chemistry - Physical Chemistry, Martin-Luther-University Halle-Wittenberg, von-Danckelmann-Platz 4, D-06120 Halle, Germany. alfred.blume.@chemie.uni-halle.de
authors.forename: Alfred
authors.initials: A
authors.lastname: Blume
authors.forename: Simon
authors.initials: S
authors.lastname: Drescher
authors.forename: Annette
authors.initials: A
authors.lastname: Meister
authors.forename: Gesche
authors.initials: G
authors.lastname: Graf
authors.forename: Bodo
authors.initials: B
authors.lastname: Dobner
mesh_terms: D008823:Micelles; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D057139:Nanofibers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D010767:Phosphorylcholine / Q000737:chemistry; D013329:Structure-Activity Relationship; D013535:Suspensions; D013696:Temperature
chemical_list: D008823:Micelles; D010743:Phospholipids; D013535:Suspensions; D010767:Phosphorylcholine