title: [The verification possibilities of immunochips under low content of antibodies to Core-antigen of virus of hepatitis C].
abstract: The detection of antibodies to Core-antigen of virus of hepatitis C in test-systems for solid-phase immune-enzyme analysis with low optical density can be a result not only of true availability of antibodies but an effect of nonspecific reaction of blood serum. The diagnostic possibilities of immunochips to be used in immune-enzyme analysis for verification of availability of markers of viral hepatitis C were investigated in conditions of low positive reaction of blood serum to core-antigen. It is established that immunochips and immunoblots have similar specificity concerning detection of antibodies to Core-antigen. At that, in immunochips antibodies to nonstructural antigens of virus of hepatitis C were additionally detected in more than 90% of samples.
authors.forename: A A
authors.initials: AA
authors.lastname: Potapova
authors.forename: T A
authors.initials: TA
authors.lastname: Chekanova
authors.forename: M L
authors.initials: ML
authors.lastname: Markelov
authors.forename: E A
authors.initials: EA
authors.lastname: Pudova
authors.forename: N P
authors.initials: NP
authors.lastname: Kirdiashkina
authors.forename: G A
authors.initials: GA
authors.lastname: Shipulina
authors.forename: V M
authors.initials: VM
authors.lastname: Dronova
authors.forename: N N
authors.initials: NN
authors.lastname: Potekaeva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification* / Q000472:pathogenicity; D006526:Hepatitis C / Q000097:blood / Q000175:diagnosis* / Q000821:virology; D018937:Hepatitis C Antibodies / Q000097:blood / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D014758:Viral Core Proteins / Q000097:blood / Q000302:isolation & purification*
chemical_list: D018937:Hepatitis C Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014758:Viral Core Proteins; C433031:hepatitis C protein F, Hepatitis C virus