title: Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures.
abstract: Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA, Fax: (+1) 732-445-5312; http://chem.rutgers.edu/∼kbleeweb.
authors.forename: Aniruddh
authors.initials: A
authors.lastname: Solanki
authors.forename: Sy-Tsong Dean
authors.initials: ST
authors.lastname: Chueng
authors.forename: Perry T
authors.initials: PT
authors.lastname: Yin
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kappera
authors.forename: Manish
authors.initials: M
authors.lastname: Chhowalla
authors.forename: Ki-Bum
authors.initials: KB
authors.lastname: Lee
mesh_terms: D001369:Axons / Q000187:drug effects*; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D006108:Graphite / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D053758:Nanoparticles; D058953:Neural Stem Cells / Q000166:cytology* / Q000187:drug effects; D010087:Oxides / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D010087:Oxides; D012822:Silicon Dioxide; D006108:Graphite
keywords: axonal alignment; graphene-coated nanostructures; neural stem cells; stem cell differentiation