title: Asymmetric Preparation ofprim-,sec-, andtert-Amines Employing Selected Biocatalysts.
abstract: This account focuses on the application of ω-transaminases, lyases, and oxidases for the preparation of amines considering mainly work from our own lab. Examples are given to access α-chiral primary amines from the corresponding ketones as well as terminal amines from primary alcohols via a two-step biocascade. 2,6-Disubstituted piperidines, as examples for secondary amines, are prepared by biocatalytical regioselective asymmetric monoamination of designated diketones followed by spontaneous ring closure and a subsequent diastereoselective reduction step. Optically puretert-amines such as berbines andN-methyl benzylisoquinolines are obtained by kinetic resolution via an enantioselective aerobic oxidative C-C bond formation.
authors.affiliation: Department of Chemistry, University of Graz , Heinrichstrasse 28, A-8010 Graz, Austria ; ACIB GmbH c/o Department of Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kroutil
authors.forename: Eva-Maria
authors.initials: EM
authors.lastname: Fischereder
authors.forename: Christine S
authors.initials: CS
authors.lastname: Fuchs
authors.forename: Horst
authors.initials: H
authors.lastname: Lechner
authors.forename: Francesco G
authors.initials: FG
authors.lastname: Mutti
authors.forename: Desiree
authors.initials: D
authors.lastname: Pressnitz
authors.forename: Aashrita
authors.initials: A
authors.lastname: Rajagopalan
authors.forename: Johann H
authors.initials: JH
authors.lastname: Sattler
authors.forename: Robert C
authors.initials: RC
authors.lastname: Simon
authors.forename: Elina
authors.initials: E
authors.lastname: Siirola