title: Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies.
abstract: Zebrafish developmental toxicity testing is an emerging field, which faces considerable challenges regarding data meta-analysis and the establishment of standardized test protocols. Here, we present an initial correlation study on toxicity of 133 chemicals based on data in the literature to ascertain predictive developmental toxicity endpoints. We found that the physical properties of chemicals (BCF or logP) did not fully predict lethality or developmental outcomes. Instead, individual outcomes such as pericardial edema and yolk sac edema were more reliable indicators of developmental toxicity. In addition, we ranked the chemicals based on toxicity with the Toxicological Priority Index (ToxPi) program and via a teratogenic ratio, and found that perfluorooctane sulfonate (PFOS) had the highest ToxPi score, triphenyltin acetate had the highest average ToxPi score (corrected for missing data and having more than 4 outcomes), and N-methyl-dithiocarbamate had the highest teratogenic ratio.
authors.affiliation: University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, Houston, TX 77204, USA.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Ducharme
authors.forename: Leif E
authors.initials: LE
authors.lastname: Peterson
authors.forename: Emilio
authors.initials: E
authors.lastname: Benfenati
authors.forename: David
authors.initials: D
authors.lastname: Reif
authors.forename: Catherine W
authors.initials: CW
authors.lastname: McCollum
authors.forename: Jan-Åke
authors.initials: JÅ
authors.lastname: Gustafsson
authors.forename: Maria
authors.initials: M
authors.lastname: Bondesson
mesh_terms: D020003:1-Octanol / Q000737:chemistry; D000818:Animals; D004625:Embryo, Nonmammalian / Q000002:abnormalities / Q000187:drug effects*; D013723:Teratogens / Q000737:chemistry / Q000633:toxicity*; D018675:Toxicity Tests; D014867:Water / Q000737:chemistry; D015027:Zebrafish
chemical_list: D013723:Teratogens; D014867:Water; D020003:1-Octanol
keywords: Developmental toxicity; Meta-analysis; Teratogen; ToxPi; Zebrafish