title: The changing face of percutaneous image-guided biopsy: molecular profiling and genomic analysis in current practice.
abstract: Oncology is undergoing a revolutionary change. Image-guided biopsy is expected to play an increasingly important role in this radical transformation. Current concepts of disease and treatment are based on an established set of physical signs and symptoms and laboratory tests broken down by organ system. However, soon diseases will be categorized and treated based on much more specific and detailed molecular and genetic information. This transformation in how disease is categorized and treated will depend on the ability to harvest tissue from tumors and analyze it appropriately.
authors.affiliation: Department of Radiology, University of California, San Francisco, San Francisco, CA 94143-0628, USA. dustyn.marshall@ucsf.edu
authors.forename: Dustyn
authors.initials: D
authors.lastname: Marshall
authors.forename: Jeanne M
authors.initials: JM
authors.lastname: Laberge
authors.forename: Brandie
authors.initials: B
authors.lastname: Firetag
authors.forename: Theodore
authors.initials: T
authors.lastname: Miller
authors.forename: Robert K
authors.initials: RK
authors.lastname: Kerlan
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D023281:Genomics; D006801:Humans; D061705:Image-Guided Biopsy; D008495:Medical Oncology / Q000379:methods*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D018579:Patient Selection; D010641:Phenotype; D057285:Precision Medicine; D011237:Predictive Value of Tests; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: EGFR; FISH; FNA; H&E; HCC; IHC; MMR; NSCLC; PCR; RCC; epidermal growth factor receptor; fine-needle aspiration; fluorescence in situ hybridization; hematoxylin and eosin; hepatocellular carcinoma; immunohistochemistry; mismatch repair; non–small-cell lung cancer; polymerase chain reaction; renal cell carcinoma