title: [Adaptive phenomenon of ischemic postconditioning of the heart. Perspectives of clinical use].
abstract: Analysis of experimental data indicates that aging, metabolic syndrome may be serious obstacle against realization of cardioprotective effect of postconditioning. The moderate hypercholesterolemia, postinfarction cardiosclerosis and cardiac hypertrophy do not abolish protective effect of postconditioning in experimental animals. The issue whether diabetes mellitus and arterial hypertension affect an efficacy of postconditioning is a subject of discussion. Clinical investigations testify on cardioprotective impact of postconditioning in patients with acute myocardial infarction and cardiosurgery patients. At the same time, it is remained unclear when after coronary artery occlusion postconditioning exhibits cardioprotective effect. It is remained unknown how do affect aging, diabetes mellitus, metabolic syndrome, arterial hypertension, myocardial hypertrophy, cardiac postinfarction remodeling and efficacy postconditioning in clinical praxis. It is required a further clinical investigations turning the development pharmacological approaches to prophylaxis of reperfusion injury of the heart.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: A G
authors.initials: AG
authors.lastname: Mrochek
authors.forename: I G
authors.initials: IG
authors.lastname: Khaliulin
authors.forename: L
authors.initials: L
authors.lastname: Hanus
authors.forename: J M
authors.initials: JM
authors.lastname: Pei
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology / Q000628:therapy; D003920:Diabetes Mellitus / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006937:Hypercholesterolemia / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy; D057775:Ischemic Postconditioning; D024821:Metabolic Syndrome / Q000503:physiopathology / Q000628:therapy; D009203:Myocardial Infarction / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*