title: Statistical genetic analysis of serological measures of common, chronic infections in Alaska Native participants in the GOCADAN study.
abstract: This paper describes genetic investigations of seroreactivity to five common infectious pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Antibody titers and seroprevalence were available for 495 to 782 (depending on the phenotype) family members at two time points, approximately 15 years apart, for Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and herpes simplex virus 2 (HSV-2). Seroprevalence rates indicate that infections with most of these pathogens are common (≥20% for all of them, >80% for H. pylori, CMV, and HSV-1). Seropositive individuals typically remain seropositive over time, with seroreversion rates of <1% to 10% over ∼15 years. Antibody titers were significantly heritable for most pathogens, with the highest estimate being 0.61 for C. pneumoniae. Significant genome-wide linkage evidence was obtained for C. pneumoniae on chromosome 15 (logarithm of odds, LOD score of 3.13). These results demonstrate that individual host genetic differences influence antibody measures of common infections in this population, and further investigation may elucidate the underlying immunological processes and genes involved.
authors.affiliation: Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas.
authors.forename: Rohina
authors.initials: R
authors.lastname: Rubicz
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhu
authors.forename: Sandra
authors.initials: S
authors.lastname: Laston
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Cole
authors.forename: V Saroja
authors.initials: VS
authors.lastname: Voruganti
authors.forename: Sven O E
authors.initials: SO
authors.lastname: Ebbesson
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.forename: Jean W
authors.initials: JW
authors.lastname: Maccluer
authors.forename: Michael
authors.initials: M
authors.lastname: Davidson
authors.forename: Jason G
authors.initials: JG
authors.lastname: Umans
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
authors.forename: Harald H H
authors.initials: HH
authors.lastname: Göring
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000413:Alaska; D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000235:genetics* / Q000382:microbiology / Q000821:virology; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human / Q000235:genetics; D006306:Health Surveys; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification; D018259:Herpesvirus 1, Human / Q000276:immunology / Q000302:isolation & purification; D018258:Herpesvirus 2, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007198:Indians, North American / Q000235:genetics*; D007239:Infections / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology / Q000821:virology; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D016036:Seroepidemiologic Studies; D012698:Serologic Tests; D013997:Time Factors; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D002097:C-Reactive Protein
keywords: Chlamydophila pneumoniae; Helicobacter pylori; Inupiaq; antibodies; cytomegalovirus; heritability; herpes simplex virus 1; herpes simplex virus 2; linkage