title: Comments on Rithidech, K.N.; et al. Lack of genomic instability in bone marrow cells of SCID mice exposed whole-body to low-dose radiation. Int. J. Environ. Res. Public Health 2013, 10, 1356-1377.
abstract: I would like to take issue with Rithidech et al., authors of the paper entitled "Lack of genomic instability in mice at low doses" [1] who claim to have shown that their results on the measurement of late occurring chromosome aberrations after irradiation of SCID mice with X-rays show that lower doses (0.05 Gy) do not induce genomic instability. Their earlier work at higher doses (0.1 and 1.0 Gy) on the same strain of mouse indicated that de novo chromosome aberrations were detected at 6 months post-irradiation. This was taken, almost certainly correctly, to be an indication of the presence of genomic instability: late appearing chromosome damage, as the authors note, seems to be a reliable indicator of the process. The lack of de novo chromosome aberrations at 6 months post-irradiation, however, cannot be taken as evidence of the absence of genomic instability. In drawing their conclusion of a "lack of genomic instability …." the authors have committed two category errors.
authors.affiliation: Department of Environmental Sciences, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. keith.baverstock@uef.fi
authors.forename: Keith
authors.initials: K
authors.lastname: Baverstock
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000528:radiation effects*; D004249:DNA Damage / Q000528:radiation effects*; D042822:Genomic Instability; D008297:Male