title: Two new phenolic glycosides from Gnaphalium affine D. Don and their anti-complementary activity.
abstract: Two new phenolic glycosides, named gnaphaffine A and B (compounds 1 and 2), were isolated from Gnaphalium affine. together with six known compounds, including caffeic acid (3), everlastoside L (4), isorhamnetin-7-O-β-D-glucopyranoside (5), quercetin- 3-O-β-D-glucopyranoside (6), scutellarein-7-O-β-D-glucoside (7) and api-genin-7-O-β-D- glucopyranoside (8). Their structures were elucidated by spectroscopic methods, including ESI-MS and 2D NMR spectroscopy (HMQC and HMBC). All compounds were evaluated for their anti-complementary activity on the classical pathway of the complement system in vitro.
authors.affiliation: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Li
authors.forename: Doudou
authors.initials: D
authors.lastname: Huang
authors.forename: Wansheng
authors.initials: W
authors.lastname: Chen
authors.forename: Zhongxin
authors.initials: Z
authors.lastname: Xi
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Guanghui
authors.initials: G
authors.lastname: Huang
authors.forename: Lianna
authors.initials: L
authors.lastname: Sun
mesh_terms: D051056:Complement Inactivating Agents / Q000737:chemistry / Q000494:pharmacology*; D003165:Complement System Proteins / Q000187:drug effects*; D006027:Glycosides / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D036622:Gnaphalium / Q000378:metabolism*; D008516:Medicine, Chinese Traditional; D010636:Phenols / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D028321:Plant Preparations / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D051056:Complement Inactivating Agents; D006027:Glycosides; D010636:Phenols; D028321:Plant Preparations; D003165:Complement System Proteins