title: TRPC signaling mechanisms and therapeutic opportunities: trapdoors are monitored by gatekeepers.
abstract: This Review summarizes our current state of knowledge of the functional role of TRPC channels in health and disease, with particular emphasis on current advancements in the field. Additionally, this Review provides an up-to-date summary of SKF-96365 acting on TRPC channels, and discusses strategies to further investigate the potential of these channels for therapeutic intervention.
authors.affiliation: Lab for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, Pakistan.
authors.forename: Ammad Ahmad
authors.initials: AA
authors.lastname: Farooqi
authors.forename: Asma M
authors.initials: AM
authors.lastname: Riaz
authors.forename: Shahzad
authors.initials: S
authors.lastname: Bhatti
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use; D015398:Signal Transduction / Q000502:physiology*; D050052:TRPC Cation Channels / Q000502:physiology*
chemical_list: D007093:Imidazoles; D050052:TRPC Cation Channels; C063159:1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole; D002118:Calcium