title: Oral Disintegration Tablets of Stavudine for HIV Management: A New Technological Approach.
abstract: Stavudine oral disintegration tablets were formulated to minimize the bitter taste and to reduce the first-pass hepatic metabolism. The various precompression parameters like the angle of repose, bulk density, compressibility index and Hausner's ratio were determined for the powder blend. In this study, 14 formulations of stavudine oral disintegration tablet were prepared by direct compression method. The tablets were evaluated for weight variation, percentage friability, disintegration time, hardness, wetting time and water absorption ratio. The in vitro dissolution study results of the batch S1 (stavudine+crospovidone+sodium starch glycollate) are encouraging as highest dissolution rate (99.2% in 100 min) and lowest time of disintegration (56 s) was achieved. The in vivo drug release studies were carried out in rabbits and the relative bioavailability of formulation S1 was found to be 2.83 times greater than that of conventional tablets.
authors.affiliation: Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore-641 004, India.
authors.forename: V
authors.initials: V
authors.lastname: Sankar
authors.forename: B
authors.initials: B
authors.lastname: Ramakrishna
authors.forename: P Shalini
authors.initials: PS
authors.lastname: Devi
authors.forename: S
authors.initials: S
authors.lastname: Karthik
keywords: Crospovidone and sodium starch glycollate; HIV; oral disintegration tablets; stavudine