title: Demonstrated efficacy of a pilot heterologous whole-spore vaccine against Microsporidial gill disease in rainbow trout.
abstract: Intraperitoneal vaccines using whole viable spores of the microsporidian Glugea anomala or Glugea hertwigi reduced the numbers of branchial xenomas by 80% and 91%, respectively, after a standard experimental infection of juvenile rainbow trout with the microsporidian Loma salmonae. Similar significant results were obtained when killed-spore preparations were used.
authors.affiliation: Department of Pathology & Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
authors.forename: J E
authors.initials: JE
authors.lastname: Harkness
authors.forename: N J
authors.initials: NJ
authors.lastname: Guselle
authors.forename: D J
authors.initials: DJ
authors.lastname: Speare
mesh_terms: D000818:Animals; D005393:Fish Diseases / Q000276:immunology / Q000517:prevention & control*; D005657:Fungal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D005880:Gills / Q000382:microbiology / Q000473:pathology; D050220:Glugea / Q000276:immunology*; D007274:Injections, Intraperitoneal; D016881:Microsporidiosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D017686:Oncorhynchus mykiss; D013172:Spores, Fungal / Q000276:immunology; D016896:Treatment Outcome; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D005657:Fungal Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated