title: Olfactory dysfunction in patients with idiopathic intracranial hypertension.
abstract: OBJECTIVE
  Although accumulating evidence suggests that a malfunction of the CSF system in idiopathic intracranial hypertension (IIH) may give rise to olfactory dysfunction, little objective knowledge is available at present about the olfactory capacity of patients with this condition.
  
  
  METHODS
  Seventeen patients with IIH and 17 age- and sex-matched controls were included. The extended Sniffin' Sticks procedure was used to test odor threshold, discrimination, and identification (TDI).
  
  
  RESULTS
  Median (interquartile range) values of the composite TDI score (29 [26.5-35.5] vs 35 [34-37], p = 0.003) were reduced in patients with IIH. Furthermore, Spearman correlation revealed reduced TDI values in patients with a recent clinical deterioration of IIH (r = 0.66, p = 0.004).
  
  
  CONCLUSIONS
  Our pilot study provides new evidence that olfaction is impaired in patients with IIH, especially in those who have been newly diagnosed or who have experienced a recent clinical deterioration.
authors.affiliation: Department of Neurology, Charité-Universitätsmedizin Berlin, Germany. hagen.kunte@charite.de
authors.forename: Hagen
authors.initials: H
authors.lastname: Kunte
authors.forename: Felix
authors.initials: F
authors.lastname: Schmidt
authors.forename: Golo
authors.initials: G
authors.lastname: Kronenberg
authors.forename: Jan
authors.initials: J
authors.lastname: Hoffmann
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmidt
authors.forename: Lutz
authors.initials: L
authors.lastname: Harms
authors.forename: Onder
authors.initials: O
authors.lastname: Goektas
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D009812:Odorants; D000857:Olfaction Disorders / Q000175:diagnosis / Q000209:etiology*; D011559:Pseudotumor Cerebri / Q000150:complications*; D012903:Smell / Q000502:physiology*