title: Visceral adiposity influences glucose and glycogen metabolism in control and hyperlipidic-fed animals.
abstract: BACKGROUND
  Evidences suggest that fat intake, visceral obesity and intracellular lipids are related to insulin impairment.
  
  
  OBJECTIVE
  The objective of the present paper was correlate visceral obesity and metabolic alterations in control (CTR) and hyperlipidic cafeteria diet (CFT) fed animals.
  
  
  METHODS
  After 6 months of diet treatment, liver and muscle of the male rats were utilized to determined glucose uptake and glycogen metabolism after administration of 0.4I U/kg insulin in vivo, and correlate the visceral adiposity to these two parameters.
  
  
  RESULTS
  Ample range of physiologic answers to body composition in metabolic profile of the both diets was found. No differences were found in glycemia and triacylglycerol after insulin action in both groups, however CFT group accumulated higher adiposity, mostly visceral fat, and showed lower glycogen content in the liver. We also found an inverse correlation between visceral adiposity and glucose uptake and a decrease of the glycogen synthase active form in the liver. CTR animals demonstrated an inverse correlation between glucose uptake and visceral adiposity in the muscle.
  
  
  CONCLUSIONS
  It was observed a variability of metabolic alterations in animals which can be related to degree of accumulation of abdominal adiposity and ingestion of diet fats. Further studies will be required to clarify the reasons for the observed liver alterations in CFT and muscle alterations in CTR animals.
authors.affiliation: Faculty of Ceilandia, University of Brasilia, Brasilia, DF, Brazil. dany.kaiser@gmail.com
authors.forename: Danielle
authors.initials: D
authors.lastname: Kaiser de Souza
authors.forename: Fabiana A
authors.initials: FA
authors.lastname: de Souza
authors.forename: Luciano Stürmer
authors.initials: LS
authors.lastname: de Fraga
authors.forename: Signorá
authors.initials: S
authors.lastname: Peres Konrad
authors.forename: Adriane
authors.initials: A
authors.lastname: Belló-Klein
authors.forename: Roselis Silveira
authors.initials: RS
authors.lastname: Martins da Silva
authors.forename: Luiz Carlos R
authors.initials: LC
authors.lastname: Kucharski
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000818:Animals; D001823:Body Composition / Q000502:physiology; D016000:Cluster Analysis; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004435:Eating / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism*; D006949:Hyperlipidemias / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D008099:Liver / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004041:Dietary Fats; D006003:Glycogen; D005947:Glucose