title: Decreased plasma nesfatin-1 levels in patients with acute myocardial infarction.
abstract: Nesfatin-1 is a novel anorexigenic hormone which has close relationship with diabetes, obese, anorexia nervosa, psychiatric disorders and neurogenic diseases. The aim of our study was to evaluate levels of plasma nesfatin-1 among patients presenting with coronary artery disease and the correlation between nesfatin-1 levels and other clinical parameters. Fasting plasma levels of nesfatin-1 were tested in 48 acute myocardial infarction (AMI) patients, 74 stable angina pectoris (SAP) patients and 34 control subjects. All of them were examined by coronary angiography. The severity of coronary atherosclerosis was assessed using the Gensini score. Plasma nesfatin-1 levels were significantly lower in AMI group than SAP group or control group (0.91±0.08 ng/mL vs. 0.98±0.19 ng/mL and 1.09±0.39 ng/mL, respectively, P<0.05). In AMI patients, plasma nesfatin-1 levels were negatively correlated with high-sensitivity C-reactive protein, neutrophil% or Gensini scores. Such information implies that lower nesfatin-1 concentration may play a very important role in the development of AMI.
authors.affiliation: Department of Cardiology, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Dai
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.forename: Yanping
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhengzhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Shoudong
authors.initials: S
authors.lastname: Wang
authors.forename: Mingqing
authors.initials: M
authors.lastname: Xing
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Sun
authors.forename: Huamin
authors.initials: H
authors.lastname: Ding
mesh_terms: D000787:Angina Pectoris / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000097:blood*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D002097:C-Reactive Protein
keywords: Acute myocardial infarction; Angina pectoris; Angiography; Nesfatin-1