title: Precancerous lesions in the stomach: from biology to clinical patient management.
abstract: Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions.
authors.affiliation: Department of Medicine - DIMED, Surgical Pathology & Cytopathology Unit, University of Padova, Padova, Italy. massimo.rugge@unipd.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Rugge
authors.forename: Lisette G
authors.initials: LG
authors.lastname: Capelle
authors.forename: Rocco
authors.initials: R
authors.lastname: Cappellesso
authors.forename: Donato
authors.initials: D
authors.lastname: Nitti
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Kuipers
mesh_terms: D005757:Gastritis, Atrophic / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D016481:Helicobacter Infections / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D011230:Precancerous Conditions / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy