title: A concise synthesis of xestospongic acid methyl ester with pancreatic lipase inhibitory activity.
abstract: Xestospongic acid methyl ester, a naturally brominated fatty acid with potent pancreatic lipase inhibitory activity in vitro, was synthesized from 5-hexynol in 30% total yield.
authors.affiliation: a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai , 201203 , China.
authors.forename: Jing-Xu
authors.initials: JX
authors.lastname: Gong
authors.forename: He-Yao
authors.initials: HY
authors.lastname: Wang
authors.forename: Wen-Fei
authors.initials: WF
authors.lastname: He
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors*; D008386:Marine Biology; D015394:Molecular Structure; D010179:Pancreas / Q000201:enzymology*; D047131:Xestospongia / Q000737:chemistry
chemical_list: D005231:Fatty Acids, Unsaturated; D006842:Hydrocarbons, Brominated; C584347:xestospongic acid methyl ester; D008049:Lipase