title: Redo aortic valve replacement in a patient with immunoglobulin A deficiency and hemophilia A.
abstract: Immunoglobulin A (IgA) deficiency may result in the development of anti-IgA antibodies. Such antibodies may result in anaphylaxis when patients receive standard blood products. Hemophilia A is a deficiency of clotting factor VIII that results in a significant coagulopathy and bleeding in the perioperative period unless precautions are taken. We present a case of successful management of combined hemophilia A and IgA deficiency in a patient undergoing repeated sternotomy for aortic valve replacement.
authors.affiliation: Division of Cardiac Anesthesia, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. mfitzsimons@partners.org
authors.forename: Michael G
authors.initials: MG
authors.lastname: Fitzsimons
authors.forename: Ken
authors.initials: K
authors.lastname: Walton
authors.forename: Robert
authors.initials: R
authors.lastname: Makar
authors.forename: Walter
authors.initials: W
authors.lastname: Dzik
authors.forename: David
authors.initials: D
authors.lastname: Kuter
authors.forename: Gus J
authors.initials: GJ
authors.lastname: Vlahakes
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D001777:Blood Coagulation; D016913:Blood Component Transfusion / Q000379:methods*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D006349:Heart Valve Diseases / Q000150:complications / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006467:Hemophilia A / Q000097:blood / Q000150:complications*; D006801:Humans; D017098:IgA Deficiency / Q000097:blood / Q000150:complications*; D008297:Male