title: Sesquiterpenoids with new carbon skeletons from the resin of Toxicodendron vernicifluum as new types of extracellular matrix inhibitors.
abstract: Toxicodenanes A-C (1-3), representing sesquiterpenoids with three new carbon skeletons, were isolated from the dried resin of Toxicodendron vernicifluum. Their structures were identified by spectroscopic data and X-ray diffraction crystallography. Their plausible biosynthetic route was proposed via the isolated intermediate (4). Compounds 2 and 3 could significantly inhibit overproduction of fibronectin, collagen IV, and IL-6 in high-glucose-induced mesangial cells in a dose- and time-dependent manner, showing their potential in diabetic nephropathy.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Jiang-Bo
authors.initials: JB
authors.lastname: He
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Yan
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D002244:Carbon; D024141:Collagen Type IV / Q000737:chemistry* / Q000187:drug effects*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D005109:Extracellular Matrix / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D005353:Fibronectins / Q000096:biosynthesis / Q000737:chemistry* / Q000187:drug effects*; D005947:Glucose / Q000737:chemistry* / Q000378:metabolism*; D015850:Interleukin-6 / Q000737:chemistry*; D050527:Mesangial Cells / Q000737:chemistry* / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012251:Toxicodendron / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D024141:Collagen Type IV; D005353:Fibronectins; D015850:Interleukin-6; D012717:Sesquiterpenes; C585993:toxicodenane A; C585994:toxicodenane B; C585995:toxicodenane C; D002244:Carbon; D005947:Glucose