title: Maintenance treatment of mild gastroesophageal reflux disease with proton pump inhibitors taken on-demand: a meta-analysis.
abstract: OBJECTIVE
  To evaluate the efficacy of on-demand strategy with proton pump inhibitors (PPIs) in mild gastroesophageal reflux disease (GERD).
  
  
  METHODS
  A literature search was conducted to identify randomized controlled clinical trials which investigating on-demand treatment with PPIs in mild GERD. The control group should be placebo or once-daily treatment. Comparison of treatment effect was performed.
  
  
  RESULTS
  Eight studies met the inclusion criteria, of which six were compared with placebo, two others with once-daily treatment. The percentage of patients unwilling to continue the study was 12.1% in the on-demand group while 39.6% in the placebo group. The meta-analysis revealed a statistically significant difference between the two groups (RR: 0.32; 95% CI: 0.23, 0.43). We obtained a similar result when compared with once-daily treatment (RR: 0.52; 95% CI: 0.34, 0.79).
  
  
  CONCLUSIONS
  This meta-analysis indicates that on-demand therapy with PPIs is superior to placebo or once-daily treatment in terms of mild GERD.
authors.forename: Yuan-Xi
authors.initials: YX
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Xuan
authors.initials: X
authors.lastname: Kong
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Tong
authors.forename: Shu-Chang
authors.initials: SC
authors.lastname: Xu
mesh_terms: D004334:Drug Administration Schedule; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors