title: Effect of estimated glomerular filtration rate on periprocedural myocardial infarction in patients undergoing elective percutaneous coronary intervention.
abstract: BACKGROUND
  Little is known about the effect of the estimated glomerular filtration rate (eGFR) on the periprocedural myocardial infarction (PMI). The aim of this study was to determine an eGFR value that is related with PMI development in patients with stable angina undergoing elective percutaneous coronary intervention (PCI).
  
  
  METHODS
  A retrospective analysis was conducted of 257 consecutive PCI patients with stable angina pectoris. The patients were divided into three groups according to eGFR: Group 1: eGFR > 90 mL/min/1.73 m(2), Group 2: eGFR = 60-89 mL/min/1.73 m(2), and Group 3: eGFR = 30-59 mL/min/1.73 m(2). Cardiac biomarkers were measured before, at 8, and at 24 h after the procedure.
  
  
  RESULTS
  Periprocedural myocardial infarction occurred in 19% of the study patients. The frequency of PMI was 13.8% in group 1, 15.2% in group 2, and 35% in group 3 (p = 0.002). There was an inverse relationship with increasing cardiac biomarkers and decreasing eGFR values. Multiple regression analysis showed that an eGFR value between 30 and 59 mL/min/1.73 m(2) was an independent variable that significantly affected PMI development after PCI.
  
  
  CONCLUSIONS
  An estimated glomerular filtration rate between 30 and 59 mL/min/1.73 m(2) is a predictor of developing PMI after elective PCI in patients with stable angina pectoris.
authors.affiliation: Bezmialem Vakif University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey. vatankulu@hotmail.com
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Vatankulu
authors.forename: Sani Namik
authors.initials: SN
authors.lastname: Murat
authors.forename: Bora
authors.initials: B
authors.lastname: Demircelik
authors.forename: Murat
authors.initials: M
authors.lastname: Turfan
authors.forename: Osman
authors.initials: O
authors.lastname: Sonmez
authors.forename: Mustafa
authors.initials: M
authors.lastname: Duran
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bacaksiz
authors.forename: Ender
authors.initials: E
authors.lastname: Ornek
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Tasal
authors.forename: Omer
authors.initials: O
authors.lastname: Goktekin
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D017558:Elective Surgical Procedures / Q000009:adverse effects / Q000379:methods; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D010043:Outcome and Process Assessment, Health Care; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000379:methods; D059035:Perioperative Period / Q000379:methods; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D052279:Creatine Kinase, MB Form