title: Nebulised DNase post-therapeutic bronchoalveolar lavage in near fatal asthma exacerbation in an adult patient refractory to conventional treatment.
abstract: Mucus plugging plays a vital role in the pathophysiology of fatal and near fatal asthma as demonstrated in various postmortem studies. There is a paucity of published literature on how to manage mucus plugging in adult patients with refractory asthma exacerbation not responding to conventional therapies as compared with its paediatric cohort. We describe a dramatic improvement with the use of rhDNase, following bronchoalveolar lavage in an intubated adult female patient, with status asthmaticus refractory to conventional treatment.
authors.affiliation: Respiratory Department, Ysbyty Gwynedd, Betsi Cadwaladr University Health Board, Bangor, UK. adyc@hotmail.com
authors.forename: A C L
authors.initials: AC
authors.lastname: Chia
authors.forename: D
authors.initials: D
authors.lastname: Menzies
authors.forename: D J
authors.initials: DJ
authors.lastname: McKeon
mesh_terms: D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid; D003851:Deoxyribonucleases / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009330:Nebulizers and Vaporizers
chemical_list: D003851:Deoxyribonucleases