title: Quality of life in lung transplantation.
abstract: Improving health-related quality of life is an important goal of lung transplantation. This review describes background concepts, including definitions, measurement and interpretation of health-related quality of life (HRQL), and other patient-reported outcomes. Lung transplantation is associated with dramatic and sustained improvements in HRQL, particularly in measures of physical health and functioning. Physical rehabilitation may augment the early improvements in HRQL, whereas bronchiolitis obliterans syndrome and psychological conditions have a negative impact. More research is needed, particularly longitudinal, multicenter studies, to better understand the trajectory and determinants of HRQL after lung transplantation, and the impact of targeted interventions to improve HRQL.
authors.affiliation: Division of Pulmonary, Critical Care, Allergy and Sleep Medicine and Cardiovascular Research Institute, UC San Francisco, San Francisco, California 94117, USA. jon.singer@ucsf.edu
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Singer
authors.forename: Lianne G
authors.initials: LG
authors.lastname: Singer
mesh_terms: D001989:Bronchiolitis Obliterans / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D016040:Lung Transplantation / Q000379:methods* / Q000534:rehabilitation; D017063:Outcome Assessment, Health Care; D011788:Quality of Life; D012107:Research Design; D013997:Time Factors; D016896:Treatment Outcome