title: IL6 and IL10 are genetic susceptibility factors of periodontal disease.
abstract: BACKGROUND
  Periodontitis is a disease mainly caused by a chronic infection of tissues that support the teeth. Several factors, such as diabetes, smoking and oral care, as well as genetic susceptibility can influence both the risk to develop periodontitis and its progression. The aim of the investigation was to test whether alleles of candidate genes were associated with periodontitis.
  
  
  METHODS
  A case control study was performed with a cohort of 184 patients with chronic periodontitis and 231 healthy controls from the Italian population. A total of six single nucleotide polymorphisms from five candidate genes, i.e., IL1A, IL1B, IL6, IL10 and vitamin D receptor, were investigated.
  
  
  RESULTS
  Evidence of association were obtained for rs1800795 mapping in IL6 (P value = 0.01) as well as for the rs1800872 mapping in IL10 (P = 0.04). The rarer variant allele lowered the risk to develop periodontitis at IL6 (Odds Ratio [OR] = 0.69 [95% confidence interval {CI} 0.51-0.93]) and increased the risk at IL10 (OR = 1.38 [95% CI 1.01-1.86]).
  
  
  CONCLUSIONS
  The present investigation indicated that polymorphisms of IL6 and IL10 constitute risk factors for chronic periodontitis, while there was no evidence implicating a specific IL1A or IL1B genotype.
authors.affiliation: Department of Histology, Embryology and Applied Biology, University of Bologna, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Scapoli
authors.forename: Ambra
authors.initials: A
authors.lastname: Girardi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Palmieri
authors.forename: Francesco
authors.initials: F
authors.lastname: Carinci
authors.forename: Tiziano
authors.initials: T
authors.lastname: Testori
authors.forename: Francesco
authors.initials: F
authors.lastname: Zuffetti
authors.forename: Riccardo
authors.initials: R
authors.lastname: Monguzzi
authors.forename: Dorina
authors.initials: D
authors.lastname: Lauritano
keywords: Bone resorption; genes; inflammation; periodontal disease; polymorphism