title: Domino elimination/nucleophilic addition in the synthesis of chiral pyrrolidines.
abstract: Polyhydroxylated pyrrolidines have been synthesized in a one-pot procedure by the addition of an organometallic reagent to isoxazolidines obtained by a 1,3-dipolar cycloaddition between nitrones and vinylsulfones. This method highlights sulfone reactivity and provides an easy approach for the preparation of chiral pyrrolidines using cyclic imines as key intermediates.
authors.affiliation: Instituto de Tecnología Química (UPV-CSIC), Universidad Politécnica de Valencia-Consejo Superior de Investigaciones Científicas, Av. de los Naranjos s/n, 46022 Valencia, Spain.
authors.forename: MariFe
authors.initials: M
authors.lastname: Flores
authors.forename: Pilar
authors.initials: P
authors.lastname: García-García
authors.forename: Narciso M
authors.initials: NM
authors.lastname: Garrido
authors.forename: Isidro S
authors.initials: IS
authors.lastname: Marcos
authors.forename: Francisca
authors.initials: F
authors.lastname: Sanz-González
authors.forename: David
authors.initials: D
authors.lastname: Díez
mesh_terms: D008968:Molecular Conformation; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011759:Pyrrolidines