title: Endovascular techniques in limb salvage: infrapopliteal angioplasty.
abstract: Critical limb ischemia (CLI) results from inadequate blood flow to supply and sustain the metabolic needs of resting muscle and tissue. Infragenicular atherosclerosis is the most common cause of CLI, and it is more likely to develop when multilevel or diffuse arterial disease coincides with compromised run-off to the foot. Reports of good technical and clinical outcomes have advanced the endovascular treatment options, which have gained a growing acceptance as the primary therapeutic strategy for CLI, especially in patients with significant risk factors for open surgical bypass. In fact, endovascular recanalization of below-the-knee arteries has proven to be feasible and safe, reduce the need for amputation, and improve wound healing. The distribution of various vascular territories or angiosomes in the foot has been recognized, and it appears advantageous to revascularize the artery supplying the territory directly associated with tissue loss. In addition, the targeted application and local delivery of drugs using drug-coated balloons (DCB) during angioplasty has the potential to improve patency rates compared to balloon angioplasty alone.
authors.affiliation: The Methodist Hospital, Houston, Texas, USA.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Naoum
authors.forename: Elias J
authors.initials: EJ
authors.lastname: Arbid
mesh_terms: D000800:Angioplasty, Balloon / Q000295:instrumentation; D002317:Cardiovascular Agents / Q000008:administration & dosage; D016638:Critical Illness; D004337:Drug Carriers; D004867:Equipment Design; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D035002:Lower Extremity / Q000098:blood supply*; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography; D016896:Treatment Outcome; D062666:Vascular Access Devices; D014654:Vascular Patency
chemical_list: D002317:Cardiovascular Agents; D004337:Drug Carriers
keywords: angiosome; balloon angioplasty; chronic limb ischemia; critical limb ischemia; diabetes; drug coated balloon; infrapopliteal artery disease