title: A new type of glucose biosensor based on surface acoustic wave resonator using Mn-doped ZnO multilayer structure.
abstract: This work reports a high-performance Mn-doped ZnO multilayer structure Love mode surface acoustic wave (SAW) biosensor for the detection of blood sugar. The biosensor was functionalized via immobilizing glucose oxidase onto a pH-sensitive polymer which was attached on Mn-doped ZnO biosensor. The fabricated SAW glucose biosensor is highly sensitive, accurate and fast with good anti-interference. The sensitivity of the SAW glucose biosensor is 7.184 MHz/mM and the accuracy is 6.96 × 10(-3)mM, which is sensitive and accurate enough for glucose monitoring. A good degree of reversibility and stability of the glucose sensor is also demonstrated, which keeps a constant differential frequency shift up to 32 days. Concerning the time response to human serum, the glucose sensor shows a value of 4.6 ± 0.4 min when increasing glucose concentrations and 7.1 ± 0.6 min when decreasing, which is less than 10 min and reach the fast response requirement for medical applications. The Mn-doped ZnO Love mode SAW biosensor can be fully integrated with CMOS Si chips and developed as a portable, passive and wireless real time detection system for blood sugar monitoring in human serum.
authors.affiliation: Institute of Thin Film Physics and Applications, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China. luojt@szu.edu.cn
authors.forename: Jingting
authors.initials: J
authors.lastname: Luo
authors.forename: Pingxiang
authors.initials: P
authors.lastname: Luo
authors.forename: Min
authors.initials: M
authors.lastname: Xie
authors.forename: Ke
authors.initials: K
authors.lastname: Du
authors.forename: Bixia
authors.initials: B
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Pan
authors.forename: Ping
authors.initials: P
authors.lastname: Fan
authors.forename: Fei
authors.initials: F
authors.lastname: Zeng
authors.forename: Dongping
authors.initials: D
authors.lastname: Zhang
authors.forename: Zhuanghao
authors.initials: Z
authors.lastname: Zheng
authors.forename: Guangxing
authors.initials: G
authors.lastname: Liang
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D001786:Blood Glucose / Q000032:analysis*; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D004867:Equipment Design; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008345:Manganese / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013016:Sound; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D004800:Enzymes, Immobilized; D008345:Manganese; D005949:Glucose Oxidase; D015034:Zinc Oxide
keywords: Biosensor; Glucose; Glucose oxidase functional immobilization; Surface acoustic wave (SAW); ZnO