title: Peritoneal metastases from colorectal cancer: patient selection for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
abstract: Cytoreductive surgery (CRS) in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) is an established treatment modality for patients with pseudomyxoma peritonei. The majority of patients with pseudomyxoma who have complete tumour removal and HIPEC are cured. Over the last decade CRS for peritoneal metastasis of colorectal origin has emerged as an effective treatment strategy in carefully selected patients. Although convincing evidence is limited, available data shows promising results. The key to a successful outcome is appropriate selection of patients. In patients with extensive peritoneal disease, where complete cytoreduction is not achieved, surgical treatment may not be beneficial and might impair quality of life. In this paper we discuss the challenges of selecting patients with colorectal peritoneal metastases who are likely to benefit from CRS with HIPEC.
authors.affiliation: Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, UK; Department of General Surgery, Medical University of Vienna, Austria. Electronic address: stefan.riss@meduniwien.ac.at.
authors.forename: S
authors.initials: S
authors.lastname: Riss
authors.forename: F
authors.initials: F
authors.lastname: Mohamed
authors.forename: S
authors.initials: S
authors.lastname: Dayal
authors.forename: T
authors.initials: T
authors.lastname: Cecil
authors.forename: A
authors.initials: A
authors.lastname: Stift
authors.forename: T
authors.initials: T
authors.lastname: Bachleitner-Hofmann
authors.forename: B
authors.initials: B
authors.lastname: Moran
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000556:secondary* / Q000628:therapy; D015179:Colorectal Neoplasms / Q000473:pathology*; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral; D018579:Patient Selection; D010534:Peritoneal Neoplasms / Q000556:secondary* / Q000628:therapy; D010537:Peritoneum / Q000601:surgery*
keywords: Colorectal cancer; Cytoreductive surgery; HIPEC; Hyperthermic intraperitoneal chemotherapy; Peritoneal metastases