title: Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases.
abstract: T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T-cell-mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T-cell-mediated skin diseases.
authors.affiliation: Department of Dermatology, Hospital del Mar, Research Group in Inflammatory Dermatologic Diseases, IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Ferran
authors.forename: Ester R
authors.initials: ER
authors.lastname: Romeu
authors.forename: Catalina
authors.initials: C
authors.lastname: Rincón
authors.forename: Marc
authors.initials: M
authors.lastname: Sagristà
authors.forename: Ana M
authors.initials: AM
authors.lastname: Giménez Arnau
authors.forename: Antonio
authors.initials: A
authors.lastname: Celada
authors.forename: Ramon M
authors.initials: RM
authors.lastname: Pujol
authors.forename: Péter
authors.initials: P
authors.lastname: Holló
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Jókai
authors.forename: Luis F
authors.initials: LF
authors.lastname: Santamaria-Babí
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D007156:Immunologic Memory; D007249:Inflammation; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D010641:Phenotype; D011565:Psoriasis / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; C063419:CTAGE1 protein, human; D008562:Membrane Glycoproteins