title: Effects of phytate on thyroid gland of rats intoxicated with cadmium.
abstract: Cadmium (Cd) is one of the most dangerous occupational and environmental toxins. The objective of the present study is to examine the potential prophylactic effects of phytic acid (PA) on thyroid hormones of male rats intoxicated with Cd. The male albino rats were divided into five groups: group I (control) was fed with the basal diet, group II was intoxicated with Cd in drinking water, groups III, IV, and V were intoxicated with Cd in drinking water and fed with the diet containing 3.5, 7, and 10 g of PA/kg, respectively. The results indicated that the serum calcium, iron (Fe), and total Fe binding capacity levels and serum T3 and T4 in Cd-treated rats of group II were decreased when compared with the control group, while PA-administered groups with Cd showed a significant improvement when compared with the Cd-treated rats only. Serum thyroid stimulating hormone (TSH) level was significantly increased in Cd-treated rats compared with the control group, while the addition of PA in diet decreased the high levels of TSH. These results indicated a prophylactic effect of PA against Cd-induced toxicity in rats.
authors.affiliation: Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt tarek967@hotmail.com.
authors.forename: Tarek Mostafa
authors.initials: TM
authors.lastname: Mohamed
authors.affiliation: Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
authors.forename: Afrah F
authors.initials: AF
authors.lastname: Salama
authors.affiliation: Biophysics Division, Physics Department, Faculty of Science, Tanta University, Tanta, Egypt.
authors.forename: Tarek M
authors.initials: TM
authors.lastname: El Nimr
authors.affiliation: Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
authors.forename: Doaa M
authors.initials: DM
authors.lastname: El Gamal
mesh_terms: D000818:Animals; D002104:Cadmium / Q000097:blood / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D019256:Cadmium Chloride / Q000008:administration & dosage; D002105:Cadmium Poisoning / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019587:Dietary Supplements; D004785:Environmental Pollutants / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism / Q000633:toxicity; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010833:Phytic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013972:Thyrotropin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism; D013974:Thyroxine / Q000819:agonists / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism; D014018:Tissue Distribution; D066007:Toxicokinetics; D014284:Triiodothyronine / Q000819:agonists / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism
chemical_list: D002614:Chelating Agents; D004785:Environmental Pollutants; D002104:Cadmium; D014284:Triiodothyronine; D010833:Phytic Acid; D013972:Thyrotropin; D019256:Cadmium Chloride; D013974:Thyroxine
keywords: Cadmium; T3; T4; TSH; phytic acid; thyroid; toxicity