title: Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies.
authors.affiliation: Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Oyer
authors.affiliation: 1] Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA [2] Department of Chemistry and Molecular Biosciences, Chemistry of Life Processes, Northwestern University, Evanston, IL, USA.
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Molecular Biosciences, Chemistry of Life Processes, Northwestern University, Evanston, IL, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: University of Maryland School of Pharmacy, University of Maryland Greenebaum Cancer Center, Baltimore, MD, USA.
authors.forename: J
authors.initials: J
authors.lastname: Shim
authors.affiliation: Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: T
authors.initials: T
authors.lastname: Ezponda
authors.affiliation: Department of Pathology, Department of Pediatrics, Institute for Cancer Genetics, Columbia University, New York, NY, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Carpenter
authors.affiliation: Department of Pathology, Department of Pediatrics, Institute for Cancer Genetics, Columbia University, New York, NY, USA.
authors.forename: M
authors.initials: M
authors.lastname: Allegretta
authors.affiliation: Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: C I
authors.initials: CI
authors.lastname: Okot-Kotber
authors.affiliation: Human Oncology and Pathogenesis Program, Leukemia Service, Department of medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Patel
authors.affiliation: Deparment of Medicine, Division of Hematology/oncology, Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Melnick
authors.affiliation: Human Oncology and Pathogenesis Program, Leukemia Service, Department of medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Levine
authors.affiliation: Department of Pathology, Department of Pediatrics, Institute for Cancer Genetics, Columbia University, New York, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Ferrando
authors.affiliation: University of Maryland School of Pharmacy, University of Maryland Greenebaum Cancer Center, Baltimore, MD, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Mackerell
authors.affiliation: Department of Chemistry and Molecular Biosciences, Chemistry of Life Processes, Northwestern University, Evanston, IL, USA.
authors.forename: N L
authors.initials: NL
authors.lastname: Kelleher
authors.affiliation: Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Licht
authors.affiliation: Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: R
authors.initials: R
authors.lastname: Popovic
mesh_terms: D002843:Chromatin / Q000378:metabolism*; D019175:DNA Methylation; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D008223:Lymphoma / Q000378:metabolism*; D017354:Point Mutation; D012097:Repressor Proteins / Q000235:genetics*
chemical_list: D002843:Chromatin; D012097:Repressor Proteins; D011495:Histone-Lysine N-Methyltransferase; C419586:NSD2 protein, human