title: Structure-activity-relationship studies on dihydrofuran-fused perhydrophenanthrenes as an anti-Alzheimer's disease agent.
abstract: As an extended study on development of anti-Alzheimer's disease agent, we newly synthesized various dihydrofuran-fused perhydrophenanthrenes via o-quinodimethane chemistry. This study revealed that the introduction of carbon side-chain on 8-position or removal of the acetal moiety on 3-position arose a cytotoxicity on rat cortical neurons. On the other hand, the ethereal or thio-ethereal substituent on 8-position enhanced the elongation effect on Aβ-damaged neurons. The necessity of the cyano group on 10b position was also proved in this structure-activity-relationship study.
authors.affiliation: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Kosuke
authors.initials: K
authors.lastname: Tamura
authors.forename: Chihiro
authors.initials: C
authors.lastname: Tohda
authors.forename: Naoki
authors.initials: N
authors.lastname: Toyooka
authors.forename: Hideo
authors.initials: H
authors.lastname: Nemoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuya
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D008956:Models, Chemical; D010616:Phenanthrenes / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D005663:Furans; D010616:Phenanthrenes