title: Protective and dysregulated T cell immunity in RSV infection.
abstract: Respiratory syncytial virus (RSV) is the most important cause of infantile bronchiolitis and a major pathogen in elderly and immunosuppressed persons. Although RSV shows limited antigenic diversity, repeated infections occur throughout life. Vaccine development has been delayed by poor immunogenicity, production issues and the fear of causing enhanced disease. T cells assist in viral clearance, but immune regulation serves to limit these responses and to prevent the exaggerated inflammatory response to RSV infection seen in children with bronchiolitis. Severe RSV disease can therefore be regarded as a dysregulated response to an otherwise trivial infection. Further insights into the role of T cells (including Th17) are needed to enable the rational design of safe, effective vaccines and novel treatments.
authors.affiliation: Centre for Respiratory Infection, National Heart and Lung Institute, Imperial College London, London W2 1PG, United Kingdom. p.openshaw@imperial.ac.uk
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Openshaw
authors.forename: Christopher
authors.initials: C
authors.lastname: Chiu
mesh_terms: D000818:Animals; D006801:Humans; D007111:Immunity, Cellular; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000276:immunology / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*