title: Light-induced generation of singlet oxygen by naked gold nanoparticles and its implications to cancer cell phototherapy.
abstract: Generation of singlet oxygen by direct irradiation of naked gold nanoparticles is observed using either continuous wave or pulsed laser sources. The underlying mechanism involves plasmon- and hot-electron-mediated reaction pathways and (1) O2 seems to significantly amplify the overall death rates during photothermal treatment of cancer cell lines in vitro.
authors.affiliation: Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology Hellas (FORTH), PO Box 1527, 711 10, Heraklion, Crete, Greece. g.pasparakis@ucl.ac.uk.
authors.forename: George
authors.initials: G
authors.lastname: Pasparakis
mesh_terms: D045744:Cell Line, Tumor; D004583:Electrons; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009369:Neoplasms / Q000532:radiotherapy* / Q000628:therapy*; D010100:Oxygen / Q000737:chemistry; D010777:Photochemistry; D010789:Phototherapy / Q000379:methods*; D017382:Reactive Oxygen Species; D026082:Singlet Oxygen / Q000737:chemistry*; D020349:Surface Plasmon Resonance; D013696:Temperature
chemical_list: D017382:Reactive Oxygen Species; D026082:Singlet Oxygen; D006046:Gold; D010100:Oxygen
keywords: cancer; gold nanoparticles; lasers; photothermal therapy; plasmons; singlet oxygen