title: UCP2, a mitochondrial protein regulated at multiple levels.
abstract: An ever-increasing number of studies highlight the role of uncoupling protein 2 (UCP2) in a broad range of physiological and pathological processes. The knowledge of the molecular mechanisms of UCP2 regulation is becoming fundamental in both the comprehension of UCP2-related physiological events and the identification of novel therapeutic strategies based on UCP2 modulation. The study of UCP2 regulation is a fast-moving field. Recently, several research groups have made a great effort to thoroughly understand the various molecular mechanisms at the basis of UCP2 regulation. In this review, we describe novel findings concerning events that can occur in a concerted manner at various levels: Ucp2 gene mutation (single nucleotide polymorphisms), UCP2 mRNA and protein expression (transcriptional, translational, and protein turn-over regulation), UCP2 proton conductance (ligands and post-transcriptional modifications), and nutritional and pharmacological regulation of UCP2.
authors.affiliation: Section of Biochemistry, Deparment of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy, massimo.donadelli@univr.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Donadelli
authors.forename: Ilaria
authors.initials: I
authors.lastname: Dando
authors.forename: Claudia
authors.initials: C
authors.lastname: Fiorini
authors.forename: Marta
authors.initials: M
authors.lastname: Palmieri
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007473:Ion Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008687:Metformin / Q000494:pharmacology; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D011499:Protein Processing, Post-Translational; D012333:RNA, Messenger / Q000378:metabolism; D000071246:Uncoupling Protein 2
chemical_list: D000903:Antibiotics, Antineoplastic; D007004:Hypoglycemic Agents; D007473:Ion Channels; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D000071246:Uncoupling Protein 2; D004317:Doxorubicin; D008687:Metformin