title: Anti-inflammatory activity of Heliotropium strigosum in animal models.
abstract: The current project was designed to evaluate the anti-inflammatory activity of crude extract of Heliotropium strigosum and its subsequent solvent fractions in post carrageenan-induced edema and post xylene-induced ear edema at 50, 100, and 200 mg/kg intraperitoneally. The results revealed marked attenuation of edema induced by carrageenan injection in a dose-dependent manner. The ethyl acetate fraction was most dominant with 73.33% inhibition followed by hexane fraction (70.66%). When the extracts were challenged against xylene-induced ear edema, again ethyl acetate and hexane fractions were most impressive with 38.21 and 35.77% inhibition, respectively. It is concluded that various extracts of H. strigosum possessed strong anti-inflammatory activity in animal models.
authors.affiliation: Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan hkdr2006@gmail.com.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Murad Ali
authors.initials: MA
authors.lastname: Khan
authors.affiliation: PCSIR Laboratories, Peshawar, Pakistan.
authors.forename: Farah
authors.initials: F
authors.lastname: Gul
authors.affiliation: Department of Pharmacy, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Sajjid
authors.initials: S
authors.lastname: Hussain
authors.affiliation: International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Ashraf
mesh_terms: D000085:Acetates / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D002351:Carrageenan; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004423:Ear; D004487:Edema / Q000276:immunology / Q000517:prevention & control*; D020834:Ethnopharmacology; D005260:Female; D028162:Heliotropium / Q000737:chemistry*; D006586:Hexanes / Q000737:chemistry; D006614:Hindlimb; D007274:Injections, Intraperitoneal; D008297:Male; D010154:Pakistan; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry; D014992:Xylenes / Q000737:chemistry
chemical_list: D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006586:Hexanes; D010936:Plant Extracts; D012997:Solvents; D014992:Xylenes; C026385:n-hexane; C007650:ethyl acetate; D002351:Carrageenan
keywords: Heliotropium strigosum; anti-inflammatory; carrageenan; ear edema