title: [Antibiotic drug minocycline: a potential therapeutic drug for methamphetamine-related disorders].
abstract: Accumulating evidence suggests a role of inflammation in the pathophysiology of a number of neuropsychiatric diseases. The second generation antibiotic drug minocycline has potent neuroprotective and anti-inflammatory effects. We reported that minocycline could attenuate behavioral abnormalities and dopaminergic neurotoxicity in mice after administration of methamphetamine or 3,4-methylenedioxymethamphetamine (MDMA). Furthermore, we reported that minocycline was effective in the animal models of schizophrenia. Moreover, a double-blind, placebo-control, cross-over study showed that minocycline was effective in the rewarding effects in healthy human subjects. In this article, we would like to discuss minocycline as a potential therapeutic drug for methamphetamine-related disorders.
authors.affiliation: Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. hashimoto@faculty.chiba-u.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Tamaki
authors.initials: T
authors.lastname: Ishima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fujita
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D008694:Methamphetamine / Q000633:toxicity*; D008911:Minocycline / Q000737:chemistry / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*; D019966:Substance-Related Disorders / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D008694:Methamphetamine; D008911:Minocycline