title: Primary cilia and graded Sonic Hedgehog signaling.
abstract: Cilia are evolutionary-conserved microtubule-containing organelles protruding from the surface of cells. They are classified into two types--primary and motile cilia. Primary cilia are nearly ubiquitous, at least in vertebrate cells, and it has become apparent that they play an essential role in the intracellular transduction of a range of stimuli. Most notable among these is Sonic Hedgehog. In this article we briefly summarize the structure and biogenesis of primary cilia. We discuss the evidence implicating cilia in the transduction of extrinsic signals. We focus on the involvement and molecular mechanism of cilia in signaling by Sonic Hedgehog in embryonic tissues, specifically the neural tube, and we discuss how cilia play an active role in the interpretation of gradients of Sonic Hedgehog (Shh) signaling.
authors.affiliation: Developmental Biology, National Institute for Medical Research, Mill Hill, London, UK.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sasai
authors.forename: James
authors.initials: J
authors.lastname: Briscoe
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000235:genetics; D002923:Cilia / Q000235:genetics / Q000648:ultrastructure*; D053823:Hedgehog Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D054259:Neural Tube / Q000254:growth & development / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D053823:Hedgehog Proteins