title: Bioactive compounds from the roots of Strophioblachia fimbricalyx.
abstract: Eight new compounds, fimbricalyxs B-D (1-3), fimbricalyxanhydrides A and B (4, 5), and fimbricalyxlactones A-C (6-8), together with three known compounds, trigonostemone (9), 3,6,9-trimethoxyphenanthropolone (10), and fimbricalyx A (11), were isolated from the roots of Strophioblachia fimbricalyx. The structures of the new compounds were elucidated on the basis of their spectroscopic data and, in the case of compounds 2, 4, and 7, confirmed by single-crystal X-ray crystallographic analysis. Compounds 1-4 and 8 were evaluated for their cytotoxicity (KB, MCF7, and NCI-H187 cancer cells) and antiplasmodial activity (Plasmodium falciparum, K1 multidrug-resistant strain). Fimbricalyx B (1) exhibited potent antiplasmodial activity with an IC50 value of 0.019 μM, while 4 was cytotoxic toward NCI-H187 cancer cells and showed antiplasmodial activities with IC50 values of 5.7 and 3.9 μM, respectively. In addition, the X-ray structure of 10 and the antiplasmodial activity of 11 are reported herein for the first time.
authors.affiliation: Nano Technology Research Unit, Department of Chemistry, Faculty of Science, Mahasarakham University and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Khamriang, Kantarawichai, Maha Sarakham, 44150, Thailand. prapairat.s@msu.ac.th
authors.forename: Prapairat
authors.initials: P
authors.lastname: Seephonkai
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Pyne
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Willis
authors.forename: Wilford
authors.initials: W
authors.lastname: Lie
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D013785:Thailand; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D006576:Heterocyclic Compounds, 4 or More Rings