title: A subset of two adherence systems, acute pro-inflammatory pap genes and invasion coding dra, fim, or sfa, increases the risk of Escherichia coli translocation to the bloodstream.
abstract: An analysis of the phylogenetic distribution and virulence genes of Escherichia coli isolates which predispose this bacteria to translocate from the urinary tract to the bloodstream is presented. One-dimensional analysis indicated that the occurrence of P fimbriae and α-hemolysin coding genes is more frequent among the E. coli which cause bacteremia. However, a two-dimensional analysis revealed that a combination of genes coding two adherence factors, namely, P + Dr, P + S, S + Dr, S + fim, and hemolysin + one adherence factor, were associated with bacteremia and, therefore, with the risk of translocation to the vascular system. The frequent and previously unrecognized co-existence of pro-inflammatory P fimbriae with the invasion promoting Dr adhesin in the same E. coli isolate may represent high-risk and potentially lethal pathogens.
authors.affiliation: Department of Microbiology, Chemical Faculty, Gdańsk University of Technology, Narutowicza 11/12, 80-233, Gdańsk, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Szemiako
authors.forename: B
authors.initials: B
authors.lastname: Krawczyk
authors.forename: A
authors.initials: A
authors.lastname: Samet
authors.forename: A
authors.initials: A
authors.lastname: Śledzińska
authors.forename: B
authors.initials: B
authors.lastname: Nowicki
authors.forename: S
authors.initials: S
authors.lastname: Nowicki
authors.forename: J
authors.initials: J
authors.lastname: Kur
mesh_terms: D016470:Bacteremia / Q000382:microbiology; D001422:Bacterial Adhesion / Q000235:genetics*; D018988:Bacterial Translocation / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D004927:Escherichia coli Infections / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000235:genetics*; D010861:Fimbriae, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D006460:Hemolysin Proteins / Q000235:genetics; D006801:Humans; D012306:Risk
chemical_list: D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins