title: [Bone architecture and strength on unloading].
abstract: The bone loss due to space flight or prolonged bed rest observes early stage of unloading and causes both decreased bone formation and increased bone resorption. Mechanical unloading induced not only both tarbecular and cortical bone loss but also greater decline bone structure in weight-bearing bone. These findings and further examination concern about pathophysiolosy will allow for better understanding of unloading-associated bone loss and for development of effective countermeasures.
authors.affiliation: Division of Endocrinology and Metabolism, The University of Tokushima Hospital, Japan.
authors.forename: Itsuro
authors.initials: I
authors.lastname: Endo
authors.forename: Toshio
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000209:etiology / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D010012:Osteogenesis / Q000502:physiology*; D016474:Weight-Bearing / Q000502:physiology; D014893:Weightlessness / Q000009:adverse effects*