title: Comparison of primarily diet-modifiable intestinal factors, connexin 43 and E-cadherin with TP53 and TGFB1 in colorectal cancer.
abstract: OBJECTIVE
  Primarily, a diet (particularly dietary lipids and vitamins) can reversibly modify intestinal expressions of a few factors like connexin 43 (Cx43), E-cadherin (Cdh1), TP53 and TGFB1 with a special impact on immunity and mutagenesis. Malignant phenotype constitutes a diet-resistant signal streaming with engagement of these molecules which are generated in autonomous ways in colorectal cancer.
  
  
  METHODS
  We aimed to compare adhesion proteins: (Cx43) and Cdh1 with TP53 and TGFB1 in colorectal adenocarcinomas. GJA1P1 and Cdh1 with TP53 and TGFB1 were detected with immunohistochemistry in the study of 106 colorectal adenocarcinomas.
  
  
  RESULTS
  There was aberrant cytoplasmic expression instead of membranous one of Cx43 and Cdh1 reflecting constitutive destruction of intercellular ties while TP53 showed nuclear expression and TGFB1 accumulated in the cytoplasm. TP53 did not correlate with Cx43 (r=0.083, p=0.397) but correlated with Cdh1 (r=0.199, p=0.041). Cdh1 associated with TGFB1 reaching almost statistical significance (r=0.188, p=0.054), while TGFB1 correlated with Cx43 (r=0.359, p=0.001).
  
  
  CONCLUSIONS
  The consequent and constant impairment of cancer intercellular communication seems to engage correlated with each other expressions of Cx43 and TGFB1 in colorectal cancer cells.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wincewicz
authors.forename: Sawka
authors.initials: S
authors.lastname: Urbaniak-Wąsik
authors.forename: Martyna
authors.initials: M
authors.lastname: Woltanowska
authors.forename: Urszula
authors.initials: U
authors.lastname: Sulkowska
authors.forename: Mariusz
authors.initials: M
authors.lastname: Koda
authors.forename: Luiza
authors.initials: L
authors.lastname: Kanczuga-Koda
authors.forename: Stanisaw
authors.initials: S
authors.lastname: Sulkowski
authors.forename: Pierre Lebard
authors.initials: PL
authors.lastname: Zamenhof
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewitowicz
authors.forename: Dorota
authors.initials: D
authors.lastname: Kozieł
authors.forename: Stanisaw
authors.initials: S
authors.lastname: Głuszek
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry*; D000328:Adult; D000368:Aged; D015820:Cadherins / Q000032:analysis*; D002450:Cell Communication; D015179:Colorectal Neoplasms / Q000737:chemistry*; D018031:Connexin 43 / Q000032:analysis*; D004032:Diet; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D053773:Transforming Growth Factor beta1 / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D015820:Cadherins; D018031:Connexin 43; C495901:TP53 protein, human; D053773:Transforming Growth Factor beta1; D016159:Tumor Suppressor Protein p53