title: Prevalence of human papillomavirus in women from Saudi Arabia.
abstract: BACKGROUND
  Human papillomavirus (HPV) infection is the main causes of cervical cancer in women worldwide. The goal of the present study was to determine the prevalence and distribution of HPV genotypes in women from Saudi Arabia. Recently, several HPV detection methods have been developed, each with different sensitivities and specificities.
  
  
  METHODS
  In this study, total forty cervical samples were subjected to polymerase chain reaction and hybridization to BioFilmChip microarray assessment.
  
  
  RESULTS
  Human papillomavirus (HPV) infections were found in 43% of the specimens. The most prevalent genotypes were HPV 16 (30%) HPV 18 (8.0%) followed by type HPV 45, occurring at 5.0%.
  
  
  CONCLUSIONS
  Our finding showed the HPV infection and prevalence is increasing at alarming rate in women of Saudi Arabia. There was no low risk infection detected in the tested samples. The BioFilmChip microarray detection system is highly accurate and suitable for detection of single and multiple infections, allowing rapid detection with less time-consumption and easier performance as compared with other methods.
authors.affiliation: Department of Obstetrics and Gynecology, King Abdulaziz University Hospital, Faculty of Medicine, Jeddah, Saudi Arabia.
authors.forename: Rola
authors.initials: R
authors.lastname: Turki
authors.forename: Khalid
authors.initials: K
authors.lastname: Sait
authors.forename: Nisreen
authors.initials: N
authors.lastname: Anfinan
authors.forename: Sayed Sartaj
authors.initials: SS
authors.lastname: Sohrab
authors.forename: Adel Mohammed
authors.initials: AM
authors.lastname: Abuzenadah
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011379:Prognosis; D012529:Saudi Arabia / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000209:etiology
chemical_list: D004279:DNA, Viral