title: Synthesis and structural characterization of hexacoordinate silicon, germanium, and titanium complexes of the E. coli siderophore enterobactin.
abstract: The E. coli siderophore enterobactin, one of the strongest Fe(III) chelators known to date, is also capable of binding Si(IV) under physiological conditions. We report on the synthesis and structural characterization of the tris(catecholate) Si(IV) -enterobactin complex and its Ge(IV) and Ti(IV) analogues. Comparative structural analysis, supported by quantum-chemical calculations, reveals the correlation between the ionic radius and the structural changes in enterobactin upon complexation.
authors.affiliation: Technische Universität Berlin, Fakultät II, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany.
authors.forename: Todor
authors.initials: T
authors.lastname: Baramov
authors.forename: Karlijn
authors.initials: K
authors.lastname: Keijzer
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Irran
authors.forename: Eva
authors.initials: E
authors.lastname: Mösker
authors.forename: Mu-Hyun
authors.initials: MH
authors.lastname: Baik
authors.forename: Roderich
authors.initials: R
authors.lastname: Süssmuth
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D004758:Enterobactin / Q000138:chemical synthesis* / Q000737:chemistry; D004926:Escherichia coli / Q000378:metabolism*; D005857:Germanium / Q000737:chemistry*; D008968:Molecular Conformation; D017262:Siderophores / Q000737:chemistry / Q000378:metabolism; D012825:Silicon / Q000737:chemistry*; D013816:Thermodynamics; D014025:Titanium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D017262:Siderophores; D005857:Germanium; D004758:Enterobactin; D014025:Titanium; D012825:Silicon
keywords: enterobactin; germanium; siderophores; silicon; titanium