title: Efficient synthesis and antioxidant evaluation of 2-aryl-3-(pyrimidin-2-yl)-thiazolidinones.
abstract: In the present study, we reported the efficient synthesis of 11 3-(pyrimidin-2-yl)-thiazolidinones in good yields using molecular sieve as the desiccant agent. In addition, we have evaluated the antioxidant capacity of the synthesized compounds by the 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH•) and the 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS(+•) ) radicals scavenging assay. Six compounds showed antioxidant activity towards DPPH• (EC50 between 16.13 and 49.94 µg/mL) and also demonstrated excellent activity regarding ABTS(+•) (TEAC: 10.32-53.52). These results showed that compounds 3-(pyrimidin-2-yl)-thiazolidinones may be easily synthesized by a less expensive procedure and could be a good starting point to the development of new antioxidant compounds.
authors.affiliation: Laboratório de Química (LAQUIABIO), Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
authors.forename: José C
authors.initials: JC
authors.lastname: Campos Júnior
authors.forename: Daniela P
authors.initials: DP
authors.lastname: Gouvêa
authors.forename: Camila da S
authors.initials: Cda S
authors.lastname: Ribeiro
authors.forename: Filipe S P
authors.initials: FS
authors.lastname: Dutra
authors.forename: Francieli M
authors.initials: FM
authors.lastname: Stefanello
authors.forename: Claudio M P
authors.initials: CM
authors.lastname: Pereira
authors.forename: Wilson
authors.initials: W
authors.lastname: Cunico
authors.forename: Geonir M
authors.initials: GM
authors.lastname: Siqueira
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry; D010084:Oxidation-Reduction; D011743:Pyrimidines / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D052160:Benzothiazoles; D016166:Free Radical Scavengers; D011743:Pyrimidines; D013451:Sulfonic Acids; D053778:Thiazolidines
keywords: Antioxidant Activity; Molecular Sieves; Thiazolidinones