title: Low-fouling, biospecific films prepared by the continuous assembly of polymers.
abstract: We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a facile and versatile technology to prepare engineered nanocoatings for various biomedical applications. Low-fouling coatings on particles were obtained by the formation of multicompositional, layered films via simple and efficient tandem CAP(ROMP) processes that are analogous to chain extension reactions. In addition, the CAP(ROMP) approach allows for the efficient postfunctionalization of the CAP films with bioactive moieties via cross-metathesis reactions between the surface-immobilized catalysts and symmetrical alkene derivatives. The combined features of the CAP(ROMP) approach (i.e., versatile polymer selection and facile functionalization) allow for the fabrication and surface modification of various types of polymer films, including those with intrinsic protein-repellent properties and selective protein recognition capabilities. This study highlights the various types of advanced coatings and materials that the CAP approach can be used to generate, which may be useful for biomedical applications.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The Universtity of Melbourne, Parkville, Victoria, Australia.
authors.forename: Stefanie N
authors.initials: SN
authors.lastname: Guntari
authors.forename: Edgar H H
authors.initials: EH
authors.lastname: Wong
authors.forename: Tor K
authors.initials: TK
authors.lastname: Goh
authors.forename: Rona
authors.initials: R
authors.lastname: Chandrawati
authors.forename: Anton
authors.initials: A
authors.lastname: Blencowe
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
authors.forename: Greg G
authors.initials: GG
authors.lastname: Qiao
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry*; D000327:Adsorption; D001360:Avidin / Q000737:chemistry; D001710:Biotin / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003432:Cross-Linking Reagents; D011094:Polyethyleneimine / Q000737:chemistry; D016062:Porosity; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000179:Acrylates; D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D001360:Avidin; D012710:Serum Albumin, Bovine; C006903:carbopol 940; D001710:Biotin; D011094:Polyethyleneimine