title: Loeffler endocarditis in a pediatric patient.
abstract: Loefler endocarditis is a potential fatal adverse event of hypereosinophilic syndrome. We report a case of a 5-year-old girl diagnosed with peripheral hypereosinophilia refractory to corticosteroid therapy who developed eosinophilia-related endocarditis. Echocardiography revealed infiltration of the left ventricular free wall and the posterior mitral leaflet causing moderate mitral regurgitation. Genetic tests failed to recognize FIPiLi-PDGRFA genotype; however imatinib, a tyrosine kinase inhibitor was initiated. After a 4-week period of treatment there was a complete resolution of eosinophilia and a complete recovery of cardiac manifestation. This case highlights the introduction of imatinib for the treatment of hypereosinophilic syndrome refractory to corticosteroid therapy even in the absence of FIPiLi-PDGRFA genotype in pediatric patients.
authors.affiliation: Pediatric Cardiology Clinic, 2nd Pediatric Department, Ahepa University Hospital, Aristotle University of Thessaloniki , Thessaloniki , Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Keivanidou
authors.forename: Andreas
authors.initials: A
authors.lastname: Giannopoulos
authors.forename: Theodotis
authors.initials: T
authors.lastname: Papageorgiou
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Hatzipantelis
authors.forename: Zoi
authors.initials: Z
authors.lastname: Pana
authors.forename: Fani
authors.initials: F
authors.lastname: Athanasiadou
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001549:Benzamides / Q000008:administration & dosage*; D002675:Child, Preschool; D004562:Electrocardiography; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D000068877:Imatinib Mesylate; D010879:Piperazines / Q000008:administration & dosage*; D011743:Pyrimidines / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate