title: Rhodium-catalyzed C3-selective alkenylation of substituted thiophene-2-carboxylic acids and related compounds.
abstract: The regioselective C3-alkenylation of thiophene-2-carboxylic acids can be achieved effectively via rhodium/silver-catalyzed oxidative coupling with alkenes, unaccompanied by decarboxylation. A wide range of substrates including brominated thiophenecarboxylic acids and furan-2-carboxylic acids can be employed together with styrenes as well as acrylates. The present catalyst system is also applicable to ortho-alkenylation of benzoic acids.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Iitsuka
authors.forename: Petra
authors.initials: P
authors.lastname: Schaal
authors.forename: Koji
authors.initials: K
authors.lastname: Hirano
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Satoh
authors.forename: Carsten
authors.initials: C
authors.lastname: Bolm
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002264:Carboxylic Acids; D009942:Organometallic Compounds; D013876:Thiophenes; C550746:2-thiophene carboxylic acid; D012238:Rhodium