title: Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery.
abstract: Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.
authors.affiliation: Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, Brno CZ-613 00, Czech Republic. vojtech.adam@mendelu.cz.
authors.forename: Iva
authors.initials: I
authors.lastname: Blazkova
authors.forename: Hoai Viet
authors.initials: HV
authors.lastname: Nguyen
authors.forename: Simona
authors.initials: S
authors.lastname: Dostalova
authors.forename: Pavel
authors.initials: P
authors.lastname: Kopel
authors.forename: Maja
authors.initials: M
authors.lastname: Stanisavljevic
authors.forename: Marketa
authors.initials: M
authors.lastname: Vaculovicova
authors.forename: Marie
authors.initials: M
authors.lastname: Stiborova
authors.forename: Tomas
authors.initials: T
authors.lastname: Eckschlager
authors.forename: Rene
authors.initials: R
authors.lastname: Kizek
authors.forename: Vojtech
authors.initials: V
authors.lastname: Adam
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D001052:Apoferritins / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D060526:Magnetic Fields; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D001052:Apoferritins