title: [Acute physical exercise increases homocysteine concentrations in young trained male subjects].
abstract: BACKGROUND
  High levels of homocysteine (Hcy) have been identified as a cardiovascular risk factor. Regarding physical exercise, the results are contradictory.
  
  
  OBJECTIVE
  The aim of this study was to determine the influence of maximal intensity exercise and submaximal constant exercise on total serum homocysteine concentrations (tHcy) and other related parameters.
  
  
  METHODS
  Ten physically active male subjects (mean age: 23.51 ± 1.84), performed two treadmill tests, a maximal test and a stable submaximal test at an intensity of 65% of maximal oxygen uptake (VO2max). Serum concentrations of tHcy, Folate, Vitamin B12 and creatinine were analysed before and after each test.
  
  
  RESULTS
  Significant increase in serum tHcy concentrations after the maximal (p < 0.05) and submaximal (p < 0.01) tests were observed. Folate and vitamin B12 concentrations also increased significantly after both tests (p < 0.05). Creatinine levels increased only after the maximal test (p < 0.001). A statistically significant inverse relationship was found between folate and tHcy concentrations (p < 0.05) at all the measurement points.
  
  
  CONCLUSIONS
  THcy levels increased significantly after acute exercise in both maximum and submaximal intensity exercises.
authors.affiliation: Departamento de Salud y Rendimiento Humano, Facultad de Ciencias de la Actividad Física y del Deporte-INEF, Universidad Politécnica de Madrid, España.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Maroto-Sánchez
authors.forename: Jara
authors.initials: J
authors.lastname: Valtueña
authors.forename: Ulrike
authors.initials: U
authors.lastname: Albers
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Benito
authors.forename: Marcela
authors.initials: M
authors.lastname: González-Gross
mesh_terms: D000332:Aerobiosis / Q000502:physiology; D003404:Creatinine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D064797:Physical Conditioning, Human / Q000502:physiology*; D014805:Vitamin B 12 / Q000097:blood; D055815:Young Adult
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D003404:Creatinine; D014805:Vitamin B 12