title: Pressure-controlled motion of single polymers through solid-state nanopores.
abstract: Voltage-biased solid-state nanopores are well established in their ability to detect and characterize single polymers, such as DNA, in electrolytes. The addition of a pressure gradient across the nanopore yields a second molecular driving force that provides new freedom for studying molecules in nanopores. In this work, we show that opposing pressure and voltage bias enables nanopores to detect and resolve very short DNA molecules, as well as to detect near-neutral polymers.
authors.affiliation: State Key Laboratory for Mesoscopic Physics and Electron Microscopy Laboratory, School of Physics, Peking University , Beijing 100871, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Lu
authors.forename: David P
authors.initials: DP
authors.lastname: Hoogerheide
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Hengbin
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Tang
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yu
authors.forename: Jene A
authors.initials: JA
authors.lastname: Golovchenko
mesh_terms: D001704:Biopolymers / Q000737:chemistry / Q000528:radiation effects; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects* / Q000648:ultrastructure; D004574:Electromagnetic Fields; D018274:Electroporation / Q000379:methods; D008422:Materials Testing; D008567:Membranes, Artificial; D008956:Models, Chemical; D008958:Models, Molecular; D009038:Motion; D058608:Nanopores / Q000648:ultrastructure*; D010316:Particle Size; D011312:Pressure
chemical_list: D001704:Biopolymers; D008567:Membranes, Artificial; D004247:DNA