title: Autophagy regulation and its role in cancer.
abstract: The modulation of macroautophagy is now recognized as one of the hallmarks of cancer cells. There is accumulating evidence that autophagy plays a role in the various stages of tumorigenesis. Depending on the type of cancer and the context, macroautophagy can be tumor suppressor or it can help cancer cells to overcome metabolic stress and the cytotoxicity of chemotherapy. Recent studies have shed light on the role of macroautophagy in tumor-initiating cells, in tumor immune response cross-talk with the microenvironment. This review is intended to provide an up-date on these aspects, and to discuss them with regard to the role of the major signaling sub-networks involved in tumor progression (Beclin 1, MTOR, p53 and RAS) and in regulating autophagy.
authors.affiliation: UPRES EA4530, Université Paris-Sud, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry cedex, France. Electronic address: severine.lorin@u-psud.fr.
authors.forename: Séverine
authors.initials: S
authors.lastname: Lorin
authors.forename: Ahmed
authors.initials: A
authors.lastname: Hamaï
authors.forename: Maryam
authors.initials: M
authors.lastname: Mehrpour
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction
keywords: Macroautophagy; Oncogenes; Signaling pathways; Tumor suppression; Tumorigenesis