title: Serum dipeptidyl peptidase 4 activity in children with type 1 diabetes mellitus.
abstract: BACKGROUND
  It is poorly understood whether dipeptidyl peptidase 4 (DPP4) activity is altered and how DPP4 contributes to glycemic control in patients with type 1 diabetes mellitus (T1DM).
  
  
  OBJECTIVE
  The aim of this study was to measure serum DPP4 activity and to assess its relationships to metabolic variables in T1DM children.
  
  
  METHODS
  Serum DPP4 activity was determined using a fluorometric assay in 43 T1DM and 26 control children.
  
  
  RESULTS
  Serum DPP4 activity was significantly higher in T1DM children than in controls (3.57 ± 0.99 vs. 2.67 ± 0.77 U/mL, p<0.001). In the T1DM children, DPP4 activity was not correlated with HbA1c, blood glucose, or diabetes duration. A significant negative correlation was found between DPP4 activity and serum adiponectin levels in the T1DM group (r=-0.35, p<0.05).
  
  
  CONCLUSIONS
  Serum DPP4 activity was increased in the T1DM children, whereas it was not associated with glycemic control. Given the negative correlation between serum DPP4 and adiponectin levels, further investigations are warranted to elucidate the role of DPP4 on insulin sensitivity in T1DM children.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iwabuchi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kamoda
authors.forename: Makoto
authors.initials: M
authors.lastname: Saito
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nozue
authors.forename: Isho
authors.initials: I
authors.lastname: Izumi
authors.forename: Takeki
authors.initials: T
authors.lastname: Hirano
authors.forename: Ryo
authors.initials: R
authors.lastname: Sumazaki
mesh_terms: D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology*; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D018819:Dipeptidyl Peptidase 4