title: Reduced expression of Na⁺/H⁺ exchanger isoform 3 (NHE-3) in preeclamptic placentas.
abstract: Although the etiology of preeclampsia is unknown, accumulated evidence suggests that the expression of a variety of syncytiotrophoblast transporters is reduced or abnormal. Here, we have examined the expression of NHE-3 in preeclamptic placentas. We found that NHE-3 expression significantly decreased and its labeling was almost undetectable in the cytosol of syncytiotrophoblast cells. Even though the inductor mechanisms of NHE-3 decrease are not clear yet, we speculated that alterations in TNF-α and aldosterone levels observed in preeclampsia might be downregulating NHE-3 expression. Further studies are needed to define whether these alterations play a direct role either in the pathogenesis or in the adaptative response of preeclampsia.
authors.affiliation: Laboratorio de Biología de la Reproducción, Cátedra de Biología Celular y Molecular, Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Dietrich
authors.forename: N
authors.initials: N
authors.lastname: Szpilbarg
authors.forename: A E
authors.initials: AE
authors.lastname: Damiano
mesh_terms: D000328:Adult; D015153:Blotting, Western; D002585:Cesarean Section; D003600:Cytosol / Q000378:metabolism / Q000473:pathology; D015536:Down-Regulation; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D016133:Polymerase Chain Reaction; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; C000613385:SLC9A3 protein, human; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers
keywords: Na((+))/H((+)) exchanger isoform 3; Placenta; Preeclampsia