title: Catalytic Asymmetric Synthesis of Branched Chiral Allylic Phenyl Ethers from (E)-Allylic Alcohols.
abstract: The first di-μ-amidate dipalladium complexes and a new di-μ-carboxylate dipalladium complex of the COP (cobalt oxazoline palladacycle) palladium(II) catalyst family are reported and characterized crystallographically. The di-μ-amidate complex3or its enantiomer (ent-3) are the first asymmetric catalysts that allow commercially available, or readily accessible, (E)-2-alkene-1-ols to be transformed to enantioenriched branched allylic aryl ethers upon reaction of their trichloroacetimidate derivatives with phenols. The 3-aryloxy-1-alkene products are formed in high enantiomeric purity (typically 90-98%ee) and useful yields (61-88%).
authors.affiliation: Department of Chemistry, University of California, Irvine, 1102 Natural Sciences II, Irvine, California, 92697-2025, U.S.A.
authors.forename: Angela C
authors.initials: AC
authors.lastname: Olson
authors.forename: Larry E
authors.initials: LE
authors.lastname: Overman
authors.forename: Helen F
authors.initials: HF
authors.lastname: Sneddon
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Ziller
keywords: asymmetric catalysis; organometallic compounds; palladium; synthetic methods