title: Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants.
authors.affiliation: Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Xu
authors.forename: Lianwen
authors.initials: L
authors.lastname: Zhang
authors.forename: Shilin
authors.initials: S
authors.lastname: Xu
authors.forename: Chao-Yie
authors.initials: CY
authors.lastname: Yang
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Luo
authors.forename: Fang
authors.initials: F
authors.lastname: Ding
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Lu
authors.forename: Yingxue
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhengchao
authors.initials: Z
authors.lastname: Tu
authors.forename: Shiliang
authors.initials: S
authors.lastname: Li
authors.forename: Duanqing
authors.initials: D
authors.lastname: Pei
authors.forename: Qian
authors.initials: Q
authors.lastname: Cai
authors.forename: Honglin
authors.initials: H
authors.lastname: Li
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Ren
authors.forename: Shaomeng
authors.initials: S
authors.lastname: Wang
authors.forename: Ke
authors.initials: K
authors.lastname: Ding
mesh_terms: D049109:Cell Proliferation; D015195:Drug Design; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D008715:Methionine / Q000737:chemistry*; D013912:Threonine / Q000737:chemistry*
chemical_list: D013912:Threonine; D008715:Methionine; D066246:ErbB Receptors
keywords: T790M mutants; drug design; inhibitors; selectivity