title: [Ki-67 and matrix metalloproteinase-9 expression in the follicular cyst, keratocystic odontogenic tumor, and ameloblastoma].
abstract: An immunohistochemical study using antibodies against Ki-67 protein was conducted, which characterized the proliferative activity of cells and matrix metalloproteinase-9 (MMP-9) in follicular cyst, variants of keratocystic odontogenic tumor (with a preponderance of hyperkeratosis and parakeratosis), and ameloblastoma. The marked proliferative activity of a parabasal cell layer (28.0+/-8.4%) was found in the keratocystic odontogenic tumor with a preponderance of parakeratosis; the proliferative activity of the peripheral layer of ameloblastoma cells was equal to 7.0+/-5.6%. The maximal matrix metalloproteinase-9 expression in the keratocystic odontogenic tumor with a predominance of hyperkeratosis was 1.1 +/-0.9 conventional units (CU) and that in the ameloblastoma was 1.9+/-1.3 CU versus 0.4+/-0.5 CU in the follicular cyst, keratocystic odontogenic tumor with a preponderance of hyperkeratosis. The values of Ki-67 and MMP-9 expression allow one to distinguish benign odontogenic cysts and tumors (follicular cyst and keratocystic odontogenic tumor with a predominance of hyperkeratosis) and odontogenic tumors characterized by an aggressive clinical course (keratocystic odontogenic tumor with a preponderance of parakeratosis and ameloblastoma).
authors.forename: I I
authors.initials: II
authors.lastname: Bibichenko
authors.forename: V A
authors.initials: VA
authors.lastname: Semkin
authors.forename: A A
authors.initials: AA
authors.lastname: Katushkina
mesh_terms: D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000378:metabolism / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005497:Follicular Cyst / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D008875:Middle Aged; D009807:Odontogenic Cysts / Q000378:metabolism / Q000473:pathology
chemical_list: D019394:Ki-67 Antigen; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9