title: Cyclic di-AMP: another second messenger enters the fray.
abstract: Nucleotide signalling molecules contribute to the regulation of cellular pathways in all forms of life. In recent years, the discovery of new signalling molecules in bacteria and archaea, as well as the elucidation of the pathways they regulate, has brought insights into signalling mechanisms not only in bacterial and archaeal cells but also in eukaryotic host cells. Here, we provide an overview of the synthesis and regulation of cyclic di-AMP (c-di-AMP), one of the latest cyclic nucleotide second messengers to be discovered in bacteria. We also discuss the currently known receptor proteins and pathways that are directly or indirectly controlled by c-di-AMP, the domain structure of the enzymes involved in its production and degradation, and the recognition of c-di-AMP by the eukaryotic host.
authors.affiliation: Section of Microbiology and Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, UK.
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Corrigan
authors.forename: Angelika
authors.initials: A
authors.lastname: Gründling
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002473:Cell Wall / Q000235:genetics / Q000378:metabolism; D015226:Dinucleoside Phosphates / Q000235:genetics / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D019761:Phosphorus-Oxygen Lyases / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D059748:Proteolysis; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D002352:Carrier Proteins; D015226:Dinucleoside Phosphates; D047908:Intracellular Signaling Peptides and Proteins; C022994:cyclic GMP-binding protein; C528998:cyclic diadenosine phosphate; D019761:Phosphorus-Oxygen Lyases; C528997:diadenylate cyclase, Bacillus subtilis