title: Acidification activates ERp44--a molecular litmus test for protein assembly.
abstract: In this issue of Molecular Cell, Vavassori et al. (2013) show that a pH-induced conformational change in the quality control protein ERp44 allows retrieval of secretory proteins that contain free thiols via a disulfide linkage from postendoplasmic reticulum compartments to prevent their premature secretion.
authors.affiliation: Department of Tumor Cell Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. linda.hendershot@stjude.org
authors.forename: Linda M
authors.initials: LM
authors.lastname: Hendershot
authors.forename: Matthias J
authors.initials: MJ
authors.lastname: Feige
authors.forename: Johannes
authors.initials: J
authors.lastname: Buchner
mesh_terms: D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D018832:Molecular Chaperones / Q000378:metabolism*; D055503:Protein Multimerization
chemical_list: C451899:ERP44 protein, human; D008565:Membrane Proteins; D018832:Molecular Chaperones