title: PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma.
abstract: Liver cancer in men is the fifth most frequently diagnosed cancer worldwide. Programmed cell death 5 (PDCD5) is an apoptosis related gene and plays an important role in the pathogenesis and development of cancer. In this study, we confirmed that the levels of PDCD5 mRNA and protein were lower in hepatocellular carcinoma (HCC) tissue compared to normal tissue. PDCD5 expression was significantly associated with HBV infection, tumor number, lymph node metastasis and the survival time of the patients with HCC. In addition, the serum levels of PDCD5 and AFP in the patients were significantly positively correlated. We also confirmed that upregulation of PDCD5 was able to inhibit cell proliferation and mobility, induce apoptosis and G1 arrest. Interestingly, PDCD5 also inhibited proteasome activity similarly to the proteosome inhibitor MG132. PDCD5 could be considered as a reliable marker of favorable prognosis of HCC patients.
authors.affiliation: Department of General Surgery, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, P.R. China.
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Fu
authors.forename: Ying
authors.initials: Y
authors.lastname: Cheng
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
authors.forename: Yong-Feng
authors.initials: YF
authors.lastname: Liu
mesh_terms: D000368:Aged; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000235:genetics* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D007976:Leupeptins / Q000494:pharmacology; D008113:Liver Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D011379:Prognosis; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000096:biosynthesis / Q000235:genetics
chemical_list: C097353:AFP protein, human; D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; D007976:Leupeptins; D009363:Neoplasm Proteins; C117283:PDCD5 protein, human; D000509:alpha-Fetoproteins; C072553:benzyloxycarbonylleucyl-leucyl-leucine aldehyde