title: Mullerian inhibiting substance expression in papillary thyroid cancer.
abstract: OBJECTIVE
  To examine the expression of Mullerian inhibiting substance (MIS) in papillary thyroid cancer.
  
  
  METHODS
  The MIS expression was examined by studying the immunohistochemistry in deparafinized sections prepared from tissue blocks of patients who were diagnosed with papillary thyroid cancer, as given in the pathology archive records (n = 23).
  
  
  RESULTS
  In all the cases studied, 50% (n = 10) showed strong staining and 50% showed moderate staining. The percentage of staining was found to be 94.2 ± 3.1% in strongly stained cases and 92.2 ± 2.1% in moderately stained cases. Normal thyroid tissues neighboring the tumor did not display any staining.
  
  
  CONCLUSIONS
  The MIS expression can be used as a significant tool in differential diagnosis of papillary thyroid cancer and also to shed light on its etiopathogenesis.
authors.affiliation: Department of General Surgery, Fırat University, Medical School, Elazig, Turkey. mustafagirgin973@hotmail.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Girgin
authors.forename: Gokhan Sami
authors.initials: GS
authors.lastname: Kılınç
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozercan
authors.forename: Bengu Cobanoglu
authors.initials: BC
authors.lastname: Simsek
authors.forename: Burcin
authors.initials: B
authors.lastname: Kavak
authors.forename: Husnu
authors.initials: H
authors.lastname: Celik
authors.forename: Bilgin
authors.initials: B
authors.lastname: Gurates
authors.forename: Burhan Hakan
authors.initials: BH
authors.lastname: Kanat
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism*; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D054304:Anti-Mullerian Hormone