title: [Soluble receptors for tumor necrosis factor and lipid metabolism as potential prognostic factors in patients with prostate cancer].
abstract: There was investigated the relationship of lipid metabolism, humoral immunity, high sensitivity C-reactive protein and soluble receptors for TNF-alpha with the presence, severity and prognosis of the disease in 85 patients with morphologically verified diagnosis of prostate cancer. Connection with the dynamics of change in PSA as a major predictor of the disease was observed for concentration sRI and sRII to TNF, PSA baseline, total cholesterol and LDL-cholesterol. During follow-up the relative risk of poor prognosis increased by 3 times, and death-in 8.7 times with increasing concentrations of soluble receptors for TNF. The concentration of soluble receptors for TNF may serve as an additional predictor of the presence and clinical course of disease in patients with prostate cancer.
authors.forename: O I
authors.initials: OI
authors.lastname: Afanas'eva
authors.forename: O A
authors.initials: OA
authors.lastname: Razova
authors.forename: E A
authors.initials: EA
authors.lastname: Utkina
authors.forename: M I
authors.initials: MI
authors.lastname: Afanas'eva
authors.forename: O A
authors.initials: OA
authors.lastname: Dmitrieva
authors.forename: G M
authors.initials: GM
authors.lastname: Zharinov
authors.forename: N S
authors.initials: NS
authors.lastname: Tavakalian
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Neklasova
authors.forename: N A
authors.initials: NA
authors.lastname: Nikitina
authors.forename: S N
authors.initials: SN
authors.lastname: Pokrovskiĭ
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D056724:Immunity, Humoral; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000378:metabolism*; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D014408:Biomarkers, Tumor; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D002097:C-Reactive Protein; D017430:Prostate-Specific Antigen