title: Toll-like receptor-4 expression by stromal fibroblasts is associated with poor prognosis in colorectal cancer.
abstract: Because of the important role in inflammation and tissue regeneration, toll-like receptors (TLR) are likely candidates to mediate effects of the innate immune system on tumorigenesis. The aim of this study was to investigate the expression and clinical relevance of TLR in colorectal cancer (CRC). The expressions of TLR3, TLR4, TLR7, and TLR9 were analyzed in 104 patients with resectable CRC by immunohistochemistry. The evaluation of the expression consisted on measuring the overall level of TLR expression and by each cell type. The results showed a direct association between the histologic grade of tumor and TLR9 expression by tumor cells. TLR4 expression by tumor cells was significantly associated with a lower rate of tumor recurrence, whereas the expression by fibroblasts was significant and independently associated with a high rate of tumor recurrence and with a shortened overall survival in patients; particularly in tumors from left colon and rectum. Therefore, TLR4 expression by fibroblasts could be a useful prognostic marker in CRC.
authors.affiliation: Unidad de Investigación, Fundación Hospital de Jove, Gijón, Asturias, Spain.
authors.forename: Noemí
authors.initials: N
authors.lastname: Eiró
authors.forename: Lucía
authors.initials: L
authors.lastname: González
authors.forename: Luis O
authors.initials: LO
authors.lastname: González
authors.forename: Belen
authors.initials: B
authors.lastname: Fernandez-Garcia
authors.forename: Alejandro
authors.initials: A
authors.lastname: Andicoechea
authors.forename: Esther
authors.initials: E
authors.lastname: Barbón
authors.forename: José L
authors.initials: JL
authors.lastname: García-Muñiz
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Vizoso
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D017154:Stromal Cells / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors