title: Eradication of multi-drug resistant bacteria by a novel Zn-doped CuO nanocomposite.
abstract: Zinc-doped copper oxide nanoparticles are synthesized and simultaneously deposited on cotton fabric using ultrasound irradiation. The optimization of the processing conditions, the specific reagent ratio, and the precursor concentration results in the formation of uniform nanoparticles with an average size of ≈30 nm. The antibacterial activity of the Zn-doped CuO Cu₀.₈₈Zn₀.₁₂O in a colloidal suspension or deposited on the fabric is tested against Escherichia coli (Gram negative) and Staphylococcus aureus (Gram positive) bacteria. A substantial enhancement of 10,000 times in the antimicrobial activity of the Zn-CuO nanocomposite compared to the pure CuO and ZnO nanoparticles (NPs) is observed after 10 min exposure to the bacteria. Similar activities are observed against multidrug-resistant bacteria (MDR), (i.e., Methicillin-resistant S. aureus and MDR E. coli) further emphasizing the efficacy of this composite. Finally, the mechanism for this enhanced antibacterial activity is presented.
authors.affiliation: Bar-Ilan University Center for Advanced Materials and Nanotechnology, Ramat-Gan 52900, Israel.
authors.forename: Eyal
authors.initials: E
authors.lastname: Malka
authors.forename: Ilana
authors.initials: I
authors.lastname: Perelshtein
authors.forename: Anat
authors.initials: A
authors.lastname: Lipovsky
authors.forename: Yakov
authors.initials: Y
authors.lastname: Shalom
authors.forename: Livnat
authors.initials: L
authors.lastname: Naparstek
authors.forename: Nina
authors.initials: N
authors.lastname: Perkas
authors.forename: Tal
authors.initials: T
authors.lastname: Patick
authors.forename: Rachel
authors.initials: R
authors.lastname: Lubart
authors.forename: Yeshayahu
authors.initials: Y
authors.lastname: Nitzan
authors.forename: Ehud
authors.initials: E
authors.lastname: Banin
authors.forename: Aharon
authors.initials: A
authors.lastname: Gedanken
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D003300:Copper; D015034:Zinc Oxide; C030973:cupric oxide
keywords: CuO; ZnO; antibacterials; doping; multi-drug resistance; nanocomposites; nanoparticles