title: Non-classical MHC Class I molecules regulating natural killer cell function.
abstract: Natural killer (NK) cells possess effector and immunoregulatory functions that are controlled by a myriad of receptor-ligand pairs, including human killer inhibitory receptor (KIR) and mouse Ly49-MHC class I interactions. We have recently shown that the NK cell inhibitory molecule Ly49A binds the non-classical MHC molecule H2-M3, thus regulating host innate immune responses to tumor initiation and metastasis.
authors.affiliation: Cancer Immunology Program; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Smyth
authors.forename: Lucy C
authors.initials: LC
authors.lastname: Sullivan
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Brooks
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Andrews
keywords: education; inhibitory; metastasis; tumor immunosurveillance