title: Angioplasty guided by intravascular ultrasound: meta-analysis of randomized clinical trials.
abstract: BACKGROUND
  The impact of intravascular ultrasound (IVUS) use on stenting has shown inconclusive results.
  
  
  OBJECTIVE
  Systematic review and meta-analysis of the impact of IVUS on stenting regarding the clinical and angiographic evolution.
  
  
  METHODS
  A search was performed in Medline/Pubmed, CENTRAL, Embase, Lilacs, Scopus and Web of Science databases. It included randomized clinical trials (RCTs) that evaluated the implantation of stents guided by IVUS, compared with those using angiography alone (ANGIO). The minimum follow-up duration was six months and the following outcomes were assessed: thrombosis, mortality, myocardial infarction, percutaneous and surgical revascularization, major adverse cardiovascular events (MACE) and restenosis. The binary outcomes were presented considering the number of events in each group; the estimates were generated by a random effects model, considering Mantel-Haenszel statistics as weighting agent and magnitude of effect for the relative risk (RR) with its respective 95% confidence interval (95%CI). Higgins I² test was used to quantify the consistency between the results of each study.
  
  
  RESULTS
  A total of 2,689 articles were evaluated, including 8 RCTs. There was a 27% reduction in angiographic restenosis (RR: 0.73, 95% CI: 0.54-0.97, I² = 51%) and statistically significant reduction in the rates of percutaneous revascularization and overall (RR: 0.88; 95% CI: 0.51 to 1.53, I² = 61%, RR: 0.73, 95% CI: 0.54 to 0.99, I² = 55%), with no statistical difference in surgical revascularization (RR: 0.95, 95% CI: 0.52-1.74, I² = 0%) in favor of IVUS vs. ANGIO. There were no differences regarding the other outcomes in the comparison between the two strategies.
  
  
  CONCLUSIONS
  Angioplasty with stenting guided by IVUS decreases the rates of restenosis and revascularization, with no impact on MACE, acute myocardial infarction, mortality or thrombosis outcomes.
authors.forename: José Albuquerque de
authors.initials: JA
authors.lastname: Figueiredo Neto
authors.forename: Iara Antonia Lustosa
authors.initials: IA
authors.lastname: Nogueira
authors.forename: Mabel Fernandes
authors.initials: MF
authors.lastname: Figueiro
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Buehler
authors.forename: Otavio
authors.initials: O
authors.lastname: Berwanger
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D054855:Drug-Eluting Stents; D006801:Humans; D019919:Prosthesis Implantation / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D018570:Risk Assessment; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*