title: A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity.
abstract: It is the first report of the novel amalgamation of 1,2,3-triazoles, piperidines, thieno pyridine rings and evaluation of their antifungal activity. The synthesized compounds showed interesting moderate to good antifungal activity, wherein they were able to discriminate between the two species Aspergillus flavus and Aspergillus niger of the same genus. In addition, the main highlight of this series is the sensitivity of the fungal strain Cryptococcus neoformans to the compounds having p-chlorobenzoyl (9h), methane sulfonyl (9i) and p-methylbenzene sulfonyl (9j) attached to the piperazine nitrogen.
authors.affiliation: Department of Chemical Technology, Dr. Babasaheb AMedian Marathwada University, Aurangabad 431004, Maharashtra, India.
authors.forename: Sunil N
authors.initials: SN
authors.lastname: Darandale
authors.forename: Nayeem A
authors.initials: NA
authors.lastname: Mulla
authors.forename: Dattatraya N
authors.initials: DN
authors.lastname: Pansare
authors.forename: Jaiprakash N
authors.initials: JN
authors.lastname: Sangshetti
authors.forename: Devanand B
authors.initials: DB
authors.lastname: Shinde
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects; D001234:Aspergillus niger / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D010880:Piperidines; D011725:Pyridines; D014230:Triazoles
keywords: 1,2,3-triazole; Piperazine and antifungal activity; Thieno pyridine