title: COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration.
abstract: Linkage analysis, positional cloning, candidate gene mutation scanning and genome-wide association study approaches have all contributed significantly to our understanding of the underlying genetic architecture of breast cancer. Taken together, these approaches have identified genetic variation that explains approximately 30% of the overall familial risk of breast cancer, implying that more, and likely rarer, genetic susceptibility alleles remain to be discovered.
authors.forename: Melissa C
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authors.lastname: Southey
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Park
authors.forename: Tu
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authors.lastname: Nguyen-Dumont
authors.forename: Ian
authors.initials: I
authors.lastname: Campbell
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authors.lastname: Thompson
authors.forename: Alison H
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authors.lastname: Trainer
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authors.lastname: Jønson
authors.forename: Inge S
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authors.forename: Alfons
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authors.lastname: Meindl
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authors.lastname: Hahnen
authors.forename: Michael R
authors.initials: MR
authors.lastname: Dufault
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authors.lastname: Chris Chan
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authors.lastname: Devilee
authors.forename: Florentine
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authors.forename: Javier
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authors.forename: Anders
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authors.forename: Douglas
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authors.lastname: Easton
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authors.lastname: Lindstrom
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authors.lastname: Kraft
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authors.lastname: Zheng
authors.forename: Yu-Tang
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authors.lastname: Gao
authors.forename: Jirong
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authors.lastname: Long
authors.forename: Susan
authors.initials: S
authors.lastname: Ramus
authors.forename: Bing-Jian
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authors.lastname: Feng
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Weitzel
authors.forename: Katherine
authors.initials: K
authors.lastname: Nathanson
authors.forename: Kenneth
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authors.lastname: Offit
authors.forename: Vijai
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authors.forename: Kasmintan
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authors.lastname: Schrader
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authors.lastname: Wang
authors.forename: Yeong C
authors.initials: YC
authors.lastname: Kim
authors.forename: Henry
authors.initials: H
authors.lastname: Lynch
authors.forename: Carrie
authors.initials: C
authors.lastname: Snyder
authors.forename: Sean
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authors.lastname: Tavtigian
authors.forename: Susan
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authors.lastname: Neuhausen
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authors.lastname: Goldgar
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D009154:Mutation