title: Pterostilbene: Biomedical applications.
abstract: Resveratrol and its naturally dimethylated analog, pterostilbene, show similar biological activities. However, the higher in vivo bioavailability of pterostilbene represents a fundamental advantage. The main focus of this review is on biomedical applications of pterostilbene. The metabolism and pharmacokinetics of this stilbene in inflammatory dermatoses and photoprotection, cancer prevention and therapy, insulin sensitivity, blood glycemia and lipid levels, cardiovascular diseases, aging, and memory and cognition are addressed. Safety and toxicity, as well as recommendations for future research and biomedical uses, are discussed. This review includes comparisons between pterostilbene and other polyphenols, with particular emphasis on resveratrol. Potential benefits of using combinations of different polyphenols are considered. Based on present evidences we conclude that pterostilbene is an active phytonutrient and also a potential drug with multiple biomedical applications.
authors.affiliation: Department of Research and Development, Green Molecular S.L., Parc Cientı´fic de la Universitat de Vale`ncia, Paterna, Spain. jose.m.estrela@uv.es
authors.forename: José M
authors.initials: JM
authors.lastname: Estrela
authors.forename: Angel
authors.initials: A
authors.lastname: Ortega
authors.forename: Salvador
authors.initials: S
authors.lastname: Mena
authors.forename: Maria L
authors.initials: ML
authors.lastname: Rodriguez
authors.forename: Miguel
authors.initials: M
authors.lastname: Asensi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D035843:Biomedical Research; D002317:Cardiovascular Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D002317:Cardiovascular Agents; D010936:Plant Extracts; D020011:Protective Agents; D013267:Stilbenes; C107773:pterostilbene