title: [About effectiveness and perspective of application of test of venereal disease research laboratory (VDRL) for diagnostic of neurosyphilis in the Russian Federation].
abstract: The comparative evaluation of effectiveness of different nontreponema tests in analysis of cerebrospinal fluid. The liquor from 100 patients with syphilis was analyzed using Bordet-Gengou test, VDRL test and micro-precipitation reaction with cardiolipin antigen. The Bordet-Gengou test and VDRL test made in Russia or abroad are equally effective in analysis of positive samples of liquor and twice surpass the same capacity of micro-precipitation reaction with cardiolipin antigen in case of neurosyphilis with symptoms and thrice surpass in case of asymptomatic neurosyphilis. VDRL test is a simple standardized nontreponema reaction which can substitute labor-consuming non-unified liquorologic complex in laboratory diagnostic of neurosyphilis. The testing of liquor on the basis of micro-precipitation reaction with cardiolipin antigen is non-effective and results in false negative results in Bordet-Gengou and VDRL positive tests determining high risk of erroneous clinical considerations.
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Kuliash
authors.forename: M I
authors.initials: MI
authors.lastname: Sabaev
authors.forename: L V
authors.initials: LV
authors.lastname: Erko
authors.forename: S G
authors.initials: SG
authors.lastname: Mardanly
authors.forename: N V
authors.initials: NV
authors.lastname: Bakhilina
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology; D019411:Clinical Laboratory Techniques; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000453:epidemiology; D012426:Russia; D013588:Syphilis Serodiagnosis / Q000379:methods*; D014210:Treponema pallidum / Q000276:immunology / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D002308:Cardiolipins