title: Rosai-Dorfman disease with extranodal involvement.
abstract: Rosai-Dorfman disease is a rare condition of marrow hematopoietic stem-cell origin. Patients can show extranodal involvement as well as lymphatic involvement, but only about 5% of extranodal cases involve intracranial lesions. A 53-year-old male was admitted to our hospital with bilateral cervical lymphadenopathy. Intracranial tumors and bone lesions were also detected. Cervical lymph node biopsy and intracranial tumor resection were performed, and histopathological examination revealed Rosai-Dorfman disease. The patient showed good clinical course without significant enlargement of the tumor. This study describes the case of a patient with Rosai-Dorfman disease presenting with massive cervical lymphadenopathy mimicking malignant neoplasm.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Fukuyama City Hospital, Hiroshima, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Shin
authors.initials: S
authors.lastname: Kariya
authors.forename: Tomoo
authors.initials: T
authors.lastname: Onoda
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ooue
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Kikuko
authors.initials: K
authors.lastname: Naka
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Okano
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nishizaki
mesh_terms: D001707:Biopsy, Needle; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003399:Craniotomy / Q000379:methods; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging / Q000379:methods*; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D019547:Neck Pain / Q000175:diagnosis / Q000209:etiology; D010784:Photomicrography; D049268:Positron-Emission Tomography / Q000379:methods; D011239:Prednisolone / Q000627:therapeutic use; D035583:Rare Diseases; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D019788:Fluorodeoxyglucose F18; D011239:Prednisolone
keywords: Rosai-Dorfman disease; emperipolesis; lymphadenopathy; proliferative disorder; sinus histiocytosis