title: Lack of association between factor V Leiden and sepsis: a meta-analysis.
abstract: Some studies evaluated the association of factor V Leiden (FVL) with sepsis risk and mortality risk. However, the results were conflicting. Thus, we performed a meta-analysis to address the association between FVL and sepsis. PubMed and EMBASE databases were searched to find relevant studies. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random effects model. Five case-control studies and 3 cohort studies were included. Overall, no significant association between FVL and sepsis risk was observed (OR = 0.93; 95% CI 0.74-1.15; P = .49). In addition, there was no significant association between FVL and sepsis-related mortality (OR = 1.17; 95% CI 0.73-1.88; P = .52). In the subgroup analysis, no increased sepsis risk and mortality risk were found in caucasian population. This meta-analysis suggested that FVL was not a risk factor for sepsis and sepsis mortality.
authors.affiliation: Department of Gerontology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Nursing, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Yanxian
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Gerontology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Weibing
authors.initials: W
authors.lastname: Song
authors.affiliation: Department of Hygiene, Sanyuanli Sanatorium of Guangzhou Military Command, Guangzhou, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Gerontology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Gerontology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zou
authors.affiliation: Department of Gerontology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China drzhongwuzhuang@163.com.
authors.forename: Wuzhuang
authors.initials: W
authors.lastname: Zhong
mesh_terms: D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D039781:PubMed; D012307:Risk Factors; D018805:Sepsis / Q000235:genetics* / Q000401:mortality*
chemical_list: C095381:factor V Leiden; D005165:Factor V
keywords: factor V Leiden; meta-analysis; sepsis