title: Changes in dynamic medial tibiofemoral contact mechanics and kinematics after injury of the anterior cruciate ligament: a cadaveric model.
abstract: The effects of tears of the anterior cruciate ligament on knee kinematics and contact mechanics during dynamic everyday activities, such as gait, remains unclear. The objective of this study was to characterize anterior cruciate ligament-deficient knee contact mechanics and kinematics during simulated gait. Nine human cadaveric knees were each augmented with a sensor capable of measuring dynamic normal contact stresses on the tibial plateau, mounted on a load-controlled simulator, and subjected to physiological, multidirectional, dynamic loads to mimic gait. Using a mixed model with random knee identifiers, confidence intervals were constructed for contact stress before and after anterior cruciate ligament transection at two points in the gait cycle at which axial force peaked (14% and 45% of the gait cycle). Kinematic and contact mechanics changes after anterior cruciate ligament transection were highly variable across knees. Nonetheless, a statistically significant increase in contact stress in the posterior-central aspect of the medial tibial plateau at 45% of the gait cycle was identified, the location of which corresponds to the location of degenerative changes that are frequently found in patients with chronic anterior cruciate ligament injury. The variability in the contact stress in other regions of the medial plateau at 45% of the gait cycle was partly explained by the variations in osseous geometry across the nine knees tested. At 14% of gait, there was no significant change in peak contact stress after anterior cruciate ligament transection in any of the four quadrants, and none of the possible explanatory variables showed statistical significance. Understanding the variable effect of anterior cruciate ligament injury on contact mechanics based on geometric differences in osseous anatomy is of paramount clinical importance and may be invaluable to select the best reconstruction techniques and counsel patients on their individual risk of subsequent chondral degeneration.
authors.affiliation: MedSport, University of Michigan Health System, Ann Arbor, MI, USA.
authors.forename: Asheesh
authors.initials: A
authors.lastname: Bedi
authors.forename: Tony
authors.initials: T
authors.lastname: Chen
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Santner
authors.forename: Saadiq
authors.initials: S
authors.lastname: El-Amin
authors.forename: Natalie H
authors.initials: NH
authors.lastname: Kelly
authors.forename: Russell F
authors.initials: RF
authors.lastname: Warren
authors.forename: Suzanne A
authors.initials: SA
authors.lastname: Maher
mesh_terms: D016118:Anterior Cruciate Ligament / Q000503:physiopathology*; D000070598:Anterior Cruciate Ligament Injuries; D002102:Cadaver; D003198:Computer Simulation; D005269:Femur / Q000503:physiopathology*; D017276:Friction; D005684:Gait; D006801:Humans; D007718:Knee Injuries / Q000503:physiopathology*; D007719:Knee Joint / Q000503:physiopathology*; D008954:Models, Biological; D013314:Stress, Mechanical; D013499:Surface Properties; D013977:Tibia / Q000503:physiopathology*
keywords: Knee joint mechanics; anterior cruciate ligament; contact stresses