title: Plasma membrane signaling in HIV-1 infection.
abstract: Plasma membrane is a multifunctional structure that acts as the initial barrier against infection by intracellular pathogens. The productive HIV-1 infection depends upon the initial interaction of virus and host plasma membrane. Immune cells such as CD4+ T cells and macrophages contain essential cell surface receptors and molecules such as CD4, CXCR4, CCR5 and lipid raft components that facilitate HIV-1 entry. From plasma membrane HIV-1 activates signaling pathways that prepare the grounds for viral replication. Through viral proteins HIV-1 hijacks host plasma membrane receptors such as Fas, TNFRs and DR4/DR5, which results in immune evasion and apoptosis both in infected and uninfected bystander cells. These events are hallmark in HIV-1 pathogenesis that leads towards AIDS. The interplay between HIV-1 and plasma membrane signaling has much to offer in terms of viral fitness and pathogenicity, and a better understanding of this interplay may lead to development of new therapeutic approaches. This article is part of a Special Issue entitled: Viral Membrane Proteins - Channels for Cellular Networking.
authors.affiliation: Department of Virology, EA 4266 "Pathogens & Inflammation", SFR FED4234, University of Franche-Comte, CHRU Besançon, F-25030 Besançon, France. Electronic address: wazim_cemb@hotmail.com.
authors.forename: Wasim
authors.initials: W
authors.lastname: Abbas
authors.affiliation: Department of Virology, EA 4266 "Pathogens & Inflammation", SFR FED4234, University of Franche-Comte, CHRU Besançon, F-25030 Besançon, France. Electronic address: georges.herbein@univ-fcomte.fr.
authors.forename: Georges
authors.initials: G
authors.lastname: Herbein
mesh_terms: D000818:Animals; D015704:CD4 Antigens / Q000502:physiology; D002462:Cell Membrane / Q000821:virology*; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D015704:CD4 Antigens; D019707:Receptors, Chemokine
keywords: Apoptosis; CD4 receptor; Chemokine; HIV-1; Lipid raft; Plasma membrane