title: Oral liquid L-thyroxine (L-t4) may be better absorbed compared to L-T4 tablets following bariatric surgery.
abstract: Drug malabsorption is a potential concern after bariatric surgery. We present four case reports of hypothyroid patients who were well replaced with thyroxine tablets to euthyroid thyrotropin (TSH) levels prior to Roux-en-Y gastric bypass surgery. These patients developed elevated TSH levels after the surgery, the TSH responded reversibly to switching from treatment with oral tablets to a liquid formulation.
authors.affiliation: Department of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, Clinica Medica, University of Brescia, 1 Medicina Spedali Civili di Brescia, Piazzale Spedali Civili n1, 25100 Brescia, Italy.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Pirola
authors.forename: Anna M
authors.initials: AM
authors.lastname: Formenti
authors.forename: Elena
authors.initials: E
authors.lastname: Gandossi
authors.forename: Francesco
authors.initials: F
authors.lastname: Mittempergher
authors.forename: Claudio
authors.initials: C
authors.lastname: Casella
authors.forename: Barbara
authors.initials: B
authors.lastname: Agosti
authors.forename: Carlo
authors.initials: C
authors.lastname: Cappelli
mesh_terms: D000328:Adult; D005260:Female; D015390:Gastric Bypass / Q000009:adverse effects; D006801:Humans; D008286:Malabsorption Syndromes / Q000188:drug therapy*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D013535:Suspensions; D013607:Tablets; D013810:Therapeutic Equivalency; D013972:Thyrotropin / Q000493:pharmacokinetics*; D013974:Thyroxine / Q000493:pharmacokinetics*; D016896:Treatment Outcome
chemical_list: D013535:Suspensions; D013607:Tablets; D013972:Thyrotropin; D013974:Thyroxine