title: [The changes in bone geometric parameters by medication].
abstract: The changes in bone geometric parameters (hip structure analysis, HSA) by medication are reviewed. HSA parameters are strongly correlated with CT parameters. Raloxifene, bisphosphonate (alendronate, risedronate, minodronate) , and denosumab improved section modulus (index for bending force) more than bone mineral density, and the improvements in section modulus are superior in intertrochanter than in femoral neck. The tendency to change in femoral shaft is approximately similar in femoral neck and intertrochanter. On the other hand, the tendency to change in these parameters in teriparatide (20μg/day) is different from raloxifene, bisphosphonate, and denosumab. Teriparatide improved section modulus and bone mineral density in femoral neck and intertrochanter, but the improvement in section modulus was approximately similar in bone mineral density and the improvement in intertrochanter is not higher than femoral neck. The femoral shaft did not show significant change.
authors.affiliation: Dept. of Orthopaedic Surgery, Sapporo Medical University, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Takada
authors.forename: Kousuke
authors.initials: K
authors.lastname: Iba
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamashita
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D058866:Osteoporotic Fractures / Q000188:drug therapy*
chemical_list: D050071:Bone Density Conservation Agents