title: Relationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients.
abstract: Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (± standard deviation [SD]) ELF/plasma ratio was 12.5 ± 6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r(2) = 0.87), suggesting the feasibility of using trough plasma voriconazole concentration as a surrogate to estimate the corresponding concentration in ELF of lung transplant recipients.
authors.affiliation: Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
authors.forename: Siow-Chin
authors.initials: SC
authors.lastname: Heng
authors.forename: Gregory I
authors.initials: GI
authors.lastname: Snell
authors.forename: Bronwyn
authors.initials: B
authors.lastname: Levvey
authors.forename: Dominic
authors.initials: D
authors.lastname: Keating
authors.forename: Glen P
authors.initials: GP
authors.lastname: Westall
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Williams
authors.forename: Helen
authors.initials: H
authors.lastname: Whitford
authors.forename: Roger L
authors.initials: RL
authors.lastname: Nation
authors.forename: Monica A
authors.initials: MA
authors.lastname: Slavin
authors.forename: Orla
authors.initials: O
authors.lastname: Morrissey
authors.forename: David C M
authors.initials: DC
authors.lastname: Kong
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000097:blood* / Q000493:pharmacokinetics; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000517:prevention & control*; D010865:Pilot Projects; D011446:Prospective Studies; D011743:Pyrimidines / Q000097:blood* / Q000493:pharmacokinetics; D014230:Triazoles / Q000097:blood* / Q000493:pharmacokinetics; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole