title: [Application of titrated target-controlled infusion anesthesia in laparoscopic colorectal surgery].
abstract: OBJECTIVE
  To evaluate the effect of titrated target-controlled infusion with propofol and remifentanil on anesthetics consumption and anesthesia depth in patients undergoing elective laparoscopic colorectal surgery.
  
  
  METHODS
  Sixty ASA I-III patients for elective laparoscopic colorectal surgery were enrolled. Titrated target-controlled infusion (TCI) with propofol and remifentanil was performed. Plasma concentration of the drugs was administered by titrated method to maintain bispectral index (BIS) in the range of 40-60 with systolic blood pressure (SBP) fluctuation within 20% of the basic value. BIS, SBP, plasma concentration of propofol and remifentanil were recorded at different time points. Awareness during operation was inquired postoperatively.
  
  
  RESULTS
  During the entire anesthesia period, the blood pressure was stable and BIS was maintained less than 60. There was no awareness during operation. The plasma concentrations (95% confidence interval) for TCI of propofol and remifentanil were 2.55-2.65 mg/L and 4.09-4.26 μg/L respectively when existing surgical stimulation during anesthesia, and the plasma target concentration of propofol was lower than the recommended dosages.
  
  
  CONCLUSIONS
  Titrated target-controlled infusions with propofol and remifentanil for elective laparoscopic colorectal surgery can maintain proper anesthesia depth and reduce the drug consumption.
authors.affiliation: Department of Anesthesia, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China. sanqingjin@hotmail.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Pang
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: San-qing
authors.initials: SQ
authors.lastname: Jin
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Chen
authors.forename: Xin-yang
authors.initials: XY
authors.lastname: Li
authors.forename: Dong-xue
authors.initials: DX
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Wen
authors.forename: Hai
authors.initials: H
authors.lastname: Jiang
authors.forename: Jing-ling
authors.initials: JL
authors.lastname: Tian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000771:Anesthesia, Intravenous / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D003107:Colorectal Surgery; D004569:Electroencephalography; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage; D015742:Propofol / Q000008:administration & dosage; D000077208:Remifentanil
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol