title: DEC-205 is a cell surface receptor for CpG oligonucleotides.
abstract: We have recently demonstrated that synthetic CpG oligonucleotides (ODNs), which function as potent immunostimulators, bind to the multi-lectin receptor DEC-205, resulting in their internalization. DEC-205-deficient mice exhibit impaired dendritic-cell and B-cell maturation, impaired cytokine responses and suboptimal cytotoxic T-cell responses. As murine and human DEC-205 are highly conserved, CpG ODNs destined to clinical applications should be designed to maximize DEC-205 binding.
authors.affiliation: Centre for Immunology; Burnet Institute; Melbourne, VIC Australia ; The Walter and Eliza Hall Institute of Medical Research; Parkville, VIC Australia ; Department of Microbiology and Immunology; University of Melbourne; Melbourne, VIC Australia.
authors.forename: Irina
authors.initials: I
authors.lastname: Caminschi
authors.forename: Simone
authors.initials: S
authors.lastname: Meuter
authors.forename: William R
authors.initials: WR
authors.lastname: Heath
keywords: CpG; TLR9; adjuvants; dendritic cells; vaccines