title: Essential genes in thyroid cancers: focus on fascin.
abstract: Although thyroid cancers are not among common malignancies, they rank as the first prevalent endocrine cancers in human. According to the results of published studies it has been shown the gradual progress from normal to the neoplastic cell in the process of tumor formation is the result of sequential genetic events. Among them we may point the mutations and rearrangements occurred in a group of proto-oncogenes, transcription factors and metastasis elements such as P53, RAS,RET,BRAF, PPARγ and Fascin. In the present article,we reviewed the most important essential genes in thyroid cancers, the role of epithelial mesenchymal transition and Fascin has been highlighted in this paper.
authors.affiliation: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, 5th floor, Dr, Shariati Hospital, North Kargar Ave, Tehran, Iran. v.haghpanah@gmail.com.
authors.forename: Hilda
authors.initials: H
authors.lastname: Samimi
authors.forename: Majid
authors.initials: M
authors.lastname: Zaki Dizaji
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ghadami
authors.forename: Abolhasan
authors.initials: A
authors.lastname: Shahzadeh Fazeli
authors.forename: Patricia
authors.initials: P
authors.lastname: Khashayar
authors.forename: Masoud
authors.initials: M
authors.lastname: Soleimani
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.forename: Vahid
authors.initials: V
authors.lastname: Haghpanah