title: Imatinib Mesylate Effectiveness in Chronic Myeloid Leukemia with Additional Cytogenetic Abnormalities at Diagnosis among Black Africans.
abstract: Imatinib mesylate provides good results in the treatment of CML in general. But what about the results of this treatment in CML associated with additional cytogenetic abnormalities at diagnosis among black Africans? For this, we retrospectively studied 27 cases of CML associated with additional cytogenetic abnormalities, diagnosed in the department of clinical hematology of the University Hospital of Yopougon in Côte d'Ivoire, from May 2005 to October 2011. The age of patients ranged from 13 to 68 years, with a mean age of 38 years and a sex ratio of 2. Patients were severely symptomatic with a high Sokal score of 67%. CML in chronic phase accounted for 67%. The prevalence of additional cytogenetic abnormalities was 29.7%. There were variants of the Philadelphia chromosome (18.5%), trisomy 8 (14.8%), complex cytogenetic abnormalities (18.5%), second Philadelphia chromosome (14.8%), and minor cytogenetic abnormalities (44.4%). Complete hematologic remission was achieved in 59%, with 52% of major cytogenetic remission. The outcome was fatal in 37% of patients. Death was related in 40% to hematologic toxicity and in 30% to acutisation. The median survival was 40 months.
authors.affiliation: Department of Clinical Hematology, Yopougon Teaching Hospital, P.O. Box 632, Abidjan 21, Cote d'Ivoire.
authors.forename: Tolo Diebkilé
authors.initials: TD
authors.lastname: Aïssata
authors.forename: Duni
authors.initials: D
authors.lastname: Sawadogo
authors.forename: Clotaire
authors.initials: C
authors.lastname: Nanho
authors.forename: Boidy
authors.initials: B
authors.lastname: Kouakou
authors.forename: N'dogomo
authors.initials: N
authors.lastname: Meité
authors.forename: N'dhatz
authors.initials: N
authors.lastname: Emeuraude
authors.forename: Ayémou
authors.initials: A
authors.lastname: Roméo
authors.forename: Sekongo
authors.initials: S
authors.lastname: Yassongui Mamadou
authors.forename: Paul
authors.initials: P
authors.lastname: Kouéhion
authors.forename: Konan
authors.initials: K
authors.lastname: Mozart
authors.forename: Gustave
authors.initials: G
authors.lastname: Koffi
authors.forename: Ibrahima
authors.initials: I
authors.lastname: Sanogo