title: Integrins in mechanotransduction.
abstract: Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions. Recent work has led to major insights into the molecular mechanisms by which these adhesions respond to forces to control cellular signaling pathways. We briefly summarize effects of forces on organs, tissues, and cells; and then discuss recent advances toward understanding molecular mechanisms.
authors.affiliation: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, United States.
authors.forename: Tyler D
authors.initials: TD
authors.lastname: Ross
authors.forename: Brian G
authors.initials: BG
authors.lastname: Coon
authors.forename: Sanguk
authors.initials: S
authors.lastname: Yun
authors.forename: Nicolas
authors.initials: N
authors.lastname: Baeyens
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Mingxing
authors.initials: M
authors.lastname: Ouyang
authors.forename: Martin A
authors.initials: MA
authors.lastname: Schwartz
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D040542:Mechanotransduction, Cellular
chemical_list: D016023:Integrins