title: No Association between Serotonin Receptor 2C-759C/T Polymorphism and Weight Change or Treatment Response to Mirtazapine in Korean Depressive Patients.
abstract: OBJECTIVE
  Activation of one or more serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of serotonergic antidepressants. The serotonin 2C (5HT 2C) receptor is known to be associated with antidepressant action and weight gain. We sought to determine whether the 5-HTR 2C receptor -759C/T polymorphism was associated with weight gain and treatment response to mirtazapine in major depressive disorder (MDD) patients.
  
  
  METHODS
  The 5-HT 2C receptor -759C/T polymorphism was analyzed in 323 MDD patients. All patients were evaluated using the 21-item Hamilton Depression Rating Scale at the beginning of the study and at 1, 2, 4, and 8 weeks of mirtazapine treatment.
  
  
  RESULTS
  There was no significant difference in the 5-HT 2C receptor -759C/T genotype distribution between responder and non-responder groups. The 5-HT 2C receptor -759C/T polymorphism was not associated with weight change over time after mirtazapine administration.
  
  
  CONCLUSIONS
  The 5-HT 2C receptor -759C/T polymorphism does not appear to be a predictor of treatment response to mirtazapine. This polymorphism was not associated with weight change after 8 weeks of mirtazapine treatment. Further investigation on other polymorphisms of the 5-HT 2C gene is required to determine whether the 5-HT 2C gene influences treatment response and weight change after mirtazapine administration in patients with major depressive disorder.
authors.affiliation: Department of Psychiatry, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Chae Keun
authors.initials: CK
authors.lastname: Oh
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Ham
authors.forename: Hun Soo
authors.initials: HS
authors.lastname: Chang
authors.forename: Jong-Woo
authors.initials: JW
authors.lastname: Paik
authors.forename: Eun-Soo
authors.initials: ES
authors.lastname: Won
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Hahn
authors.forename: Se-Hoon
authors.initials: SH
authors.lastname: Shim
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Kwon
authors.forename: Hee-Yeon
authors.initials: HY
authors.lastname: Jung
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
keywords: Major depressive disorder; Mirtazapine; Polymorphism; Serotonin 2C receptor