title: Genetic polymorphism in PDE4D gene and risk of ischemic stroke in Chinese population: a meta-analysis.
abstract: BACKGROUND
  Stroke is the second most common cause of death and major cause of disability worldwide. The SNP 83 in PDE4D gene has been suggested as a risk factor in ischemic stroke, but direct evidence from genetic association studies remains inconclusive even in Chinese population.
  
  
  METHODS
  Meta-analysis of case-control studies on the relationship between SNP 83 in PDE4D gene and susceptibility to ischemic stroke in Chinese population published domestically and abroad from January 2003 to September 2012.
  
  
  RESULTS
  9 case-control studies were selected. Meta-analysis results showed that the significant association between SNP 83 and ischemic stroke was found under the dominant model (OR = 1.34, 95% CI: 1.20-1.49) and recessive model (OR = 1.45, 95% CI: 1.19-1.76) in Chinese population. In subgroup meta-analysis, SNP 83 and atherothrombotic stroke, rather than lacunar stroke, showed the significant association under the dominant model (OR = 1.69, 95% CI: 1.41-2.01) and recessive model (OR = 1.47, 95% CI: 1.04-2.06).
  
  
  CONCLUSIONS
  The results suggest that SNP 83 in PDE4D gene is significantly associated with susceptibility to ischemic stroke in Chinese population.
authors.affiliation: Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.forename: Ruixia
authors.initials: R
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Shumin
authors.initials: S
authors.lastname: Deng
authors.forename: Qu
authors.initials: Q
authors.lastname: Li
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: He
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000235:genetics*
chemical_list: D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517376:PDE4D protein, human