title: [Possible applications of new stem cell sources in neurology].
abstract: Stem cells provide broad possibilities in modern science and medicine. This counts not only for investigations of developmental aspects but also for cell-based therapies, pharmacotoxicological testing and improvements in personalized medicine. The recent described techniques of induced pluripotent stem cells, directly induced neural stem cells and directly induced neurons are a major step forward by providing new possibilities for research on neurological diseases. Nevertheless, a variety of questions remain open regarding stem cell-based therapeutic strategies including tumorigenicity and phenotypical stability in the receptor brain. The major hope is that the new stem cell-based neural cell systems will help to understand the pathophysiology of neurodegenerative diseases. The future will show whether and how stem cells will lead to successful restorative therapies and/or to suitable cell models for neurological diseases.
authors.affiliation: Bereich Neurodegenerative Erkrankungen, Klinik und Poliklinik für Neurologie, Technische Universität Dresden, Dresden, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Hermann
authors.forename: A
authors.initials: A
authors.lastname: Storch
authors.forename: S
authors.initials: S
authors.lastname: Liebau
mesh_terms: D001921:Brain / Q000473:pathology / Q000601:surgery*; D005544:Forecasting; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D058953:Neural Stem Cells / Q000473:pathology / Q000637:transplantation*; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000601:surgery*; D009462:Neurology / Q000639:trends*; D039904:Pluripotent Stem Cells / Q000473:pathology / Q000637:transplantation*