title: Evaluation of Origin Ensemble algorithm for image reconstruction for pixelated solid-state detectors with large number of channels.
abstract: The Voxel Imaging PET (VIP) Pathfinder project intends to show the advantages of using pixelated solid-state technology for nuclear medicine applications. It proposes designs for Positron Emission Tomography (PET), Positron Emission Mammography (PEM) and Compton gamma camera detectors with a large number of signal channels (of the order of 106). For PET scanners, conventional algorithms like Filtered Back-Projection (FBP) and Ordered Subset Expectation Maximization (OSEM) are straightforward to use and give good results. However, FBP presents difficulties for detectors with limited angular coverage like PEM and Compton gamma cameras, whereas OSEM has an impractically large time and memory consumption for a Compton gamma camera with a large number of channels. In this article, the Origin Ensemble (OE) algorithm is evaluated as an alternative algorithm for image reconstruction. Monte Carlo simulations of the PET design are used to compare the performance of OE, FBP and OSEM in terms of the bias, variance and average mean squared error (MSE) image quality metrics. For the PEM and Compton camera designs, results obtained with OE are presented.
authors.affiliation: Institut de Fisica d'Altes Energies (IFAE), Edifici Cn, Universitat Autónoma de Barcelona (UAB), E-08193 Bellaterra, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Kolstein
authors.forename: G
authors.initials: G
authors.lastname: De Lorenzo
authors.forename: E
authors.initials: E
authors.lastname: Mikhaylova
authors.forename: M
authors.initials: M
authors.lastname: Chmeissani
authors.forename: G
authors.initials: G
authors.lastname: Ariño
authors.forename: Y
authors.initials: Y
authors.lastname: Calderón
authors.forename: I
authors.initials: I
authors.lastname: Ozsahin
authors.forename: D
authors.initials: D
authors.lastname: Uzun
keywords: Compton imaging; Computerized Tomography (CT) and Computed Radiography (CR); Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA); Medical-image reconstruction methods and algorithms, computer-aided so