title: Efficient one-step synthesis of pyrrolo[3,4-c]quinoline-1,3-dione derivatives by organocatalytic cascade reactions of isatins and β-ketoamides.
abstract: We describe an efficient one-step synthesis of pyrrolo[3,4-c]quinolinedione derivatives using ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and β-ketoamides. It is the first direct conversion of isatins to pyrrolo[3,4-c]quinolinedione derivatives via C-N bond cleavage and isatin ring expansion. Furthermore, this reaction provides a one-step synthetic route for the production of biologically interesting complex molecules that are generally prepared using multi-step reactions.
authors.affiliation: School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
authors.forename: Likai
authors.initials: L
authors.lastname: Xia
authors.forename: Yong Rok
authors.initials: YR
authors.lastname: Lee
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D007510:Isatin / Q000737:chemistry*; D008958:Models, Molecular; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D011758:Pyrroles; D011804:Quinolines; C026058:EDDA; D007510:Isatin; D004492:Edetic Acid