title: Serum 25-hydroxyvitamin D level is associated with arterial stiffness, left ventricle hypertrophy, and inflammation in newly diagnosed hypertension.
abstract: OBJECTIVE
  Vitamin D may modulate vascular inflammation, vascular smooth muscle cell proliferation, the renin-angiotensin system, and cardiomyocyte proliferation, myocardial fibrosis, and proliferation. These mechanisms may play a role on arterial stiffness and left ventricle hypertrophy (LVH) in hypertensive patients. We aimed to evaluate the association between serum vitamin D with arterial stiffness and LVH in patients with hypertension.
  
  
  METHODS
  We studied 133 patients with newly diagnosed hypertension [mean (SD) age, 62.9 (10.6) years]. Pulse wave velocity (PWV), which reflects arterial stiffness, was calculated using the single-point method via the Mobil-O-Graph ARCsolver algorithm. Left ventricular mass index (LVMI) was determined according to Deverux formula. The patients were divided into the following 2 groups according to serum vitamin D level: vitamin Dlow group with less than 20 ng/mL and vitamin Dhigh group with greater than or equal to 20 ng/mL.
  
  
  RESULTS
  The highest PWV, high-sensitivity C reactive protein, and LVMI values were observed in vitamin Dlow group compared with vitamin Dhigh group. Multiple linear regression analysis showed that vitamin D level was independently associated with LVMI (β = -0.235, P = 0.002) and PWV (β = -0.432, P < 0.001). Adjustment for age, sex, parathyroid hormone level, body surface area, and mean blood pressure did not modify these associations. Vitamin D level was also independently associated with high-sensitivity C reactive protein (β = -0.143, P = 0.047). However, adjustment for parathyroid hormone level or body surface area and mean blood pressure attenuate this association.
  
  
  CONCLUSIONS
  Serum 25-hyroxyvitamin D is independently related with arterial stiffness, LVH, and inflammation. Vitamin D may play a role on pathogenesis of arterial stiffness and LVH in patient with newly diagnosed hypertension.
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Kuloğlu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.forename: Gülhan Yüksel
authors.initials: GY
authors.lastname: Kalkan
authors.forename: Durmuş Yıldıray
authors.initials: DY
authors.lastname: Şahin
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Tanboğa
authors.forename: Nermin Yıldız
authors.initials: NY
authors.lastname: Koyunsever
authors.forename: Hazar
authors.initials: H
authors.lastname: Harbaloğlu
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.forename: Selahattin
authors.initials: S
authors.lastname: Akyol
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Armağan
authors.initials: A
authors.lastname: Acele
authors.forename: Murat
authors.initials: M
authors.lastname: Caylı
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D059289:Vascular Stiffness / Q000502:physiology*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D