title: Association between plasma brain-derived neurotrophic factor levels and personality traits in healthy Japanese subjects.
abstract: Although depression has been associated with decreased brain-derived neurotrophic factor (BDNF) levels for specific personality traits, there is a little information regarding the association between peripheral BDNF levels and such traits. The sample consisted of 178 healthy Japanese subjects (age range, 37.4 ± 11.5 years). All subjects filled out the Temperament and Character Inventory (TCI). Plasma BDNF levels were measured using the enzyme-linked immunosorbent assay. A simple regression analysis revealed that plasma BDNF levels were significantly correlated with harm avoidance (r=-0.177, p=0.018) and self-directedness scores (r=0.165, p=0.028). Our findings suggest that plasma BDNF levels are associated with depression-related personality traits.
authors.affiliation: Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. Electronic address: yasufuru@cc.hirosaki-u.ac.jp.
authors.forename: Norio
authors.initials: N
authors.lastname: Yasui-Furukori
authors.forename: Shoko
authors.initials: S
authors.lastname: Tsuchimine
authors.forename: Ayako
authors.initials: A
authors.lastname: Kaneda
authors.forename: Norio
authors.initials: N
authors.lastname: Sugawara
authors.forename: Masamichi
authors.initials: M
authors.lastname: Ishioka
authors.forename: Sunao
authors.initials: S
authors.lastname: Kaneko
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003863:Depression / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010551:Personality; D010555:Personality Inventory; D012044:Regression Analysis
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: Brain-derived neurotrophic factor; Personality; Plasma; Temperament and Character Inventory