title: [Carcinogenicity of acrylonitrile and evaluation of approaches to pathogenetic correction of acrylate toxicity and antitumorigenic anthracycline doxorubicin toxicity during chemotherapy].
abstract: Statistical analysis within the 20-year period showed that approximately 49% of workers who were exposed to widespread industrial poison acrylonitrile subsequently died from malignancy of different localization. The conducted experimental investigations demonstrated that acrylonitrile with the subacute intoxication of animals, the anti-tumor antibiotic doxorubicin, their combination, interwoven tumor and tumor developed against the background the introduction of acrylate and subsequent treatment doxorubicin led to onset of free-radical reactions. These reactions by themselves might stimulate development of malignancy. This fact confirms the need for antioxidant tracking of chemotherapy of tumors in the similar clinical cases.
authors.forename: M M
authors.initials: MM
authors.lastname: Tarskikh
authors.forename: M A
authors.initials: MA
authors.lastname: Shumbasov
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
mesh_terms: D000181:Acrylonitrile / Q000633:toxicity*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology; D015197:Carcinogenicity Tests; D004317:Doxorubicin / Q000633:toxicity*; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000378:metabolism; D051381:Rats
chemical_list: D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D008315:Malondialdehyde; D004317:Doxorubicin; D000181:Acrylonitrile