title: [Kynurenines in pathogenesis of endogenous psychiatric disorders].
abstract: The essential amino acid tryptophan is metabolized on the methoxyindole pathway to serotonin, melatonin and 5-hydroxyindoleacetic acid and on the kynurenine pathway to kynurenine and related neuroactive metabolites, including 3-hydroxykynurenine, kynurenic acid, quinolinic acid and xanthurenic acid. Kynurenine and related metabolites play a significant role in the pathogenesis of major depressive disorder and schizophrenia. This paper is the review of literature data on the most modern state of this problem.
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Shilov
authors.forename: M V
authors.initials: MV
authors.lastname: Bezrukov
mesh_terms: D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007737:Kynurenine / Q000031:analogs & derivatives / Q000378:metabolism*; D001523:Mental Disorders / Q000378:metabolism*; D011618:Psychotic Disorders / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*; D014977:Xanthurenates / Q000378:metabolism
chemical_list: D014977:Xanthurenates; C005045:3-hydroxykynurenine; D007737:Kynurenine; D006897:Hydroxyindoleacetic Acid; C028330:xanthurenic acid; D014364:Tryptophan