title: Downregulation of BTG3 in non-small cell lung cancer.
abstract: BTG3 is identified as a tumor suppressor gene in some malignancies. Btg3-deficient mice display a higher incidence of lung cancer. These results suggest that BTG3 plays an important role in lung tumorigenesis, although the underlying mechanisms are unknown. The BTG3 expression was detected using immunohistochemical staining and our results showed that the expression of BTG3 was reduced in lung cancer compared to benign lung tissues. We identified two BTG3 isoforms present in lung cancer: Full-length BTG3 and BTG3b lacking the 44 amino acids. BTG3 was predominantly expressed in benign lung tissues, whereas its expression was generally undetectable in lung cancer and cancer cell lines. Functional analysis revealed that BTG3 but not BTG3b inhibited lung cancer growth. Our results disclosed an important role of BTG3 in lung tumorigenesis.
authors.affiliation: Department of Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province 450008, PR China. chenxboncology@163.com
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Chen
authors.forename: Guoyong
authors.initials: G
authors.lastname: Chen
authors.forename: Xinguang
authors.initials: X
authors.lastname: Cao
authors.forename: Yudong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Tiejun
authors.initials: T
authors.lastname: Yang
authors.forename: Sidong
authors.initials: S
authors.lastname: Wei
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure; D002453:Cell Cycle / Q000235:genetics; D018797:Cell Cycle Proteins; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation; D015536:Down-Regulation / Q000235:genetics*; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: C424522:BTG3 protein, human; D018797:Cell Cycle Proteins; D011506:Proteins; D012333:RNA, Messenger
keywords: BTG3; Isoforms; Lung cancer