title: Associations of erythrocyte fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in a cohort study of middle-aged and older Chinese.
abstract: BACKGROUND
  Experimental studies suggest that elevated de novo lipogenesis (DNL) might be involved in the pathogenesis of metabolic disorders. Few prospective studies have been conducted, especially among populations with a high carbohydrate intake, to determine whether DNL fatty acids are associated with the risk of the metabolic syndrome (MetS).
  
  
  OBJECTIVE
  We aimed to investigate associations of erythrocyte fatty acids in the DNL pathway-including myristic acid (14:0), palmitic acid (16:0), palmitoleic acid (16:1n-7), hexadecenoic acid (16:1n-9), stearic acid (18:0), vaccenic acid (18:1n-7), and oleic acid (18:1n-9)-with the risk of MetS in a Chinese population with an average carbohydrate intake of >60% of energy.
  
  
  METHODS
  A total of 1176 free-living Chinese men and women aged 50-70 y from Beijing and Shanghai were included in our analysis, giving rise to 412 incident MetS cases during 6 y of follow-up. Erythrocyte fatty acids and metabolic traits were measured in these participants.
  
  
  RESULTS
  Erythrocyte fatty acids in the DNL pathway were correlated with a high ratio of carbohydrate-to-fat intake, less favorable lipid profiles, and elevated liver enzymes at baseline. In comparison with the lowest quartile, RRs (95% CIs) of MetS in the highest quartile were 1.30 (1.04, 1.62; P-trend = 0.007) for 16:1n-7, 1.48 (1.17, 1.86; P-trend < 0.001) for 16:1n-9, 1.26 (1.01, 1.56; P-trend = 0.06) for 18:1n-7, and 1.51 (1.19, 1.92; P-trend < 0.001) for 18:1n-9 after multivariate adjustment for lifestyle factors and body mass index. Moreover, 16:0 and 16:1n-7 were associated with an elevated risk of diabetes.
  
  
  CONCLUSIONS
  Our findings suggest that fatty acids in the DNL pathway are independently associated with an elevated risk of metabolic disorders.
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of the Chinese Academy of Sciences, Shanghai, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Zong
authors.forename: Jingwen
authors.initials: J
authors.lastname: Zhu
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Xingwang
authors.initials: X
authors.lastname: Ye
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.forename: Qianlu
authors.initials: Q
authors.lastname: Jin
authors.forename: He
authors.initials: H
authors.lastname: Zheng
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Yu
authors.forename: Zhenni
authors.initials: Z
authors.lastname: Zhu
authors.forename: Huaixing
authors.initials: H
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
mesh_terms: D000368:Aged; D044466:Asian People; D002681:China; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D050155:Lipogenesis; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D005227:Fatty Acids