title: Development of a palladium-catalyzed decarboxylative cross-coupling of (2-azaaryl)carboxylates with aryl halides.
abstract: A catalytic method for the decarboxylative coupling of 2-(azaaryl)carboxylates with aryl halides is described. The decarboxylative cross-coupling presented is mediated by a system catalytic in both palladium and copper without requiring stoichiometric amounts of organometallic reagents or organoboronic acids. This method circumvents additional synthetic steps required to prepare 2-azaaryl organometallics and organoborates as nucleophilic coupling partners, which are prone to protodemetallation and protodeborylation and produce potentially toxic byproducts.
authors.affiliation: Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Haley
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Gilmore
authors.forename: Brian M
authors.initials: BM
authors.lastname: Stoltz
keywords: (2-azaaryl)carboxylates; Copper; Decarboxylative cross-coupling; Palladium