title: Age-dependent effect of static magnetic field on brain tissue hydration.
abstract: Age-dependent effect of Static Magnetic Field (SMF) on rats in a condition of active and inactive Na(+)/K(+) pump was studied for comparison of brain tissues hydration state changes and magnetic sensitivity. Influence of 15 min 0, 2 Tesla (T) SMF on brain tissue hydration of three aged groups of male albino rats was studied. Tyrode's physiological solution and 10(-4) M ouabain was used for intraperitoneal injections. For animal immobilization, the liquid nitrogen was used and the definition of tissue water content was performed by tissue drying method. Initial water content in brain tissues of young animals is significantly higher than in those of adult and aged ones. SMF exposure leads to decrease of water content in brain tissues of young animals and increase in brain tissues of adult and aged ones. In case of ouabain-poisoned animals, SMF gives reversal effects on brain tissue's hydration both in young and aged animals, while no significant effect on adults is observed. It is suggested that initial state of tissue hydration could play a crucial role in animal age-dependent magnetic sensitivity and the main reason for this could be age-dependent dysfunction of Na(+)/K(+) pump.
authors.affiliation: UNESCO Chair-Life Sciences International Postgraduate Educational Center , Yerevan , Armenia.
authors.forename: Anush
authors.initials: A
authors.lastname: Deghoyan
authors.forename: Anna
authors.initials: A
authors.lastname: Nikoghosyan
authors.forename: Armenuhi
authors.initials: A
authors.lastname: Heqimyan
authors.forename: Sinerik
authors.initials: S
authors.lastname: Ayrapetyan
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D060526:Magnetic Fields / Q000009:adverse effects*; D008297:Male; D051381:Rats; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water