title: Growth of healthy term infants fed an extensively hydrolyzed casein-based or free amino acid-based infant formula: a randomized, double-blind, controlled trial.
abstract: A masked, randomized, parallel growth study was conducted in infants fed an amino acid-based formula (AF) or an extensively hydrolyzed casein-based formula (HF). Infants were enrolled between 0 and 9 days and studied to 112 days of age. Growth, formula intake, stool patterns, and serum albumin concentrations were assessed. There were no significant differences between groups in weight, length, or head circumference, gains in weight or length, or study formula intake. The number of stools parents rated as being formed, and the mean daily number of stools were greater in the HF than in the AF group at 14 and 28 days of age. Mean serum albumin concentrations were not significantly different between groups and were within the normal range. This study demonstrates that AF supports normal growth of infants comparable to that of infants fed HF during the critical first 4 months of life.
authors.affiliation: 1Abbott Nutrition, Abbott Laboratories, Columbus, OH, USA.
authors.forename: Marlene W
authors.initials: MW
authors.lastname: Borschel
authors.forename: Ekhard E
authors.initials: EE
authors.lastname: Ziegler
authors.forename: Rita Thomas
authors.initials: RT
authors.lastname: Wedig
authors.forename: Jeffery S
authors.initials: JS
authors.lastname: Oliver
mesh_terms: D000596:Amino Acids; D002364:Caseins; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology; D005243:Feces; D006128:Growth / Q000502:physiology*; D006801:Humans; D007223:Infant; D015370:Infant Equipment; D007231:Infant, Newborn; D012709:Serum Albumin / Q000032:analysis; D015430:Weight Gain / Q000502:physiology
chemical_list: D000596:Amino Acids; D002364:Caseins; D012709:Serum Albumin; C475729:casein hydrolysate
keywords: elemental formula; formula; free amino acid–based formula; hydrolysate formula; hypoallergenic; infant feeding; infant growth; weight