title: [Methylprednisolone- acute spinal cord injury, benefits or risks?].
abstract: Methylprednisolone is a synthetic glucocorticoid with a potent and long-acting anti-inflammatory, antiallergic and immunosuppressant. Its mechanism of action of methylprednisolone is the result of many cellular changes. Methylprednisolone is used in many diseases, such as rheumatic diseases, autoimmune diseases, allergic, anaphylactic shock, asthma. Methylprednisolone was also used in patients with spinal cord injury, in order to minimize neurological damage. While in the above mentioned fields of medicine is undeniable role of methylprednisolone, whereas its use in the treatment of traumatic spinal cord injury within the last few years raises a lot of controversy, and in most cases, the side effects of its use outweigh the potential benefits.
authors.affiliation: Katedra i Klinika Ortopedii i Rehabilitacji w Zakopanem Uniwersytetu Jagiellońskiego Collegium Medicum.
authors.forename: Maciej
authors.initials: M
authors.lastname: Tęsiorowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Potaczek
authors.forename: Barbara
authors.initials: B
authors.lastname: Jasiewicz
authors.forename: Jacek
authors.initials: J
authors.lastname: Sapa
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Zygmunt
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D009135:Muscular Diseases / Q000139:chemically induced; D018696:Neuroprotective Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D018696:Neuroprotective Agents; D008775:Methylprednisolone