title: Fractional carbon dioxide laser and acoustic-pressure ultrasound for transepidermal delivery of cosmeceuticals: a novel method of facial rejuvenation.
abstract: BACKGROUND
  This study aimed to determine the efficacy and safety of a new facial rejuvenation procedure that combines a fractional carbon dioxide (CO2) laser, an ultrasound emitter, and a cosmeceutical preparation to be applied intraoperatively.
  
  
  METHODS
  A split-face, double-blind randomized prospective study of 14 patients was designed, in which one half of the face was treated with a fractional CO2 laser, with the other half receiving the same laser and acoustic pressure ultrasound for transepidermal delivery of cosmeceuticals. Two semiquantitative scales and two visual analog scales were completed to evaluate the efficacy of each treatment. The results were assessed on the basis of photographs taken before treatment and then after 1, 2, and 6 months afterward. Potential adverse effects and complications were recorded.
  
  
  RESULTS
  Both treatments achieved significant improvements in all parameters evaluated (p < 0.001). The combined ultrasound and cosmeceutical treatment had better scores for reduced fine lines and wrinkles as well as for overall facial aging at 6 months (p < 0.01), with nearly 80 % overall improvement in facial aging. The treatment was well tolerated, and no unexpected adverse effects were observed. The majority of the patients (86 %) stated that they were satisfied or very satisfied with their results.
  
  
  CONCLUSIONS
  One session of fractional ablative CO2 laser and acoustic pressure ultrasound technology for transepidermal delivery of cosmeceuticals is an effective method for treating facial rejuvenation.
authors.affiliation: Instituto Médico Vilafortuny, Fundación Antoni de Gimbernat, Av. Vilafortuny 31, 43850, Cambrils, Tarragona, Spain, imv@laser-spain.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Trelles
authors.forename: F M
authors.initials: FM
authors.lastname: Leclère
authors.forename: P A
authors.initials: PA
authors.lastname: Martínez-Carpio
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D003357:Cosmetic Techniques; D003358:Cosmetics / Q000008:administration & dosage*; D004311:Double-Blind Method; D005145:Face; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010539:Permeability; D011446:Prospective Studies; D012060:Rejuvenation; D012867:Skin / Q000378:metabolism*; D015595:Skin Aging
chemical_list: D003358:Cosmetics