title: The gene Sr33, an ortholog of barley Mla genes, encodes resistance to wheat stem rust race Ug99.
abstract: Wheat stem rust, caused by the fungus Puccinia graminis f. sp. tritici, afflicts bread wheat (Triticum aestivum). New virulent races collectively referred to as "Ug99" have emerged, which threaten global wheat production. The wheat gene Sr33, introgressed from the wild relative Aegilops tauschii into bread wheat, confers resistance to diverse stem rust races, including the Ug99 race group. We cloned Sr33, which encodes a coiled-coil, nucleotide-binding, leucine-rich repeat protein. Sr33 is orthologous to the barley (Hordeum vulgare) Mla mildew resistance genes that confer resistance to Blumeria graminis f. sp. hordei. The wheat Sr33 gene functions independently of RAR1, SGT1, and HSP90 chaperones. Haplotype analysis from diverse collections of Ae. tauschii placed the origin of Sr33 resistance near the southern coast of the Caspian Sea.
authors.affiliation: Commonwealth Scientific and Industrial Research Organization (CSIRO) Plant Industry, Canberra, ACT 2601, Australia.
authors.forename: Sambasivam
authors.initials: S
authors.lastname: Periyannan
authors.forename: John
authors.initials: J
authors.lastname: Moore
authors.forename: Michael
authors.initials: M
authors.lastname: Ayliffe
authors.forename: Urmil
authors.initials: U
authors.lastname: Bansal
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.forename: Karin
authors.initials: K
authors.lastname: Deal
authors.forename: Mingcheng
authors.initials: M
authors.lastname: Luo
authors.forename: Xiuying
authors.initials: X
authors.lastname: Kong
authors.forename: Harbans
authors.initials: H
authors.lastname: Bariana
authors.forename: Rohit
authors.initials: R
authors.lastname: Mago
authors.forename: Robert
authors.initials: R
authors.lastname: McIntosh
authors.forename: Peter
authors.initials: P
authors.lastname: Dodds
authors.forename: Jan
authors.initials: J
authors.lastname: Dvorak
authors.forename: Evans
authors.initials: E
authors.lastname: Lagudah
mesh_terms: D000595:Amino Acid Sequence; D001487:Basidiomycota / Q000472:pathogenicity; D003001:Cloning, Molecular; D060467:Disease Resistance / Q000235:genetics; D017343:Genes, Plant; D006239:Haplotypes; D001467:Hordeum / Q000235:genetics; D006824:Hybridization, Genetic; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D010935:Plant Diseases / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D018547:Plant Stems / Q000382:microbiology; D030821:Plants, Genetically Modified; D006109:Poaceae / Q000235:genetics*; D026801:Synteny; D014908:Triticum / Q000235:genetics* / Q000382:microbiology*
chemical_list: D018832:Molecular Chaperones; D010940:Plant Proteins