title: Association of atherosclerotic peripheral arterial disease with adiponectin genes SNP+45 and SNP+276: a case-control study.
abstract: OBJECTIVE
  We hypothesized that adiponectin gene SNP+45 (rs2241766) and SNP+276 (rs1501299) would be associated with atherosclerotic peripheral arterial disease (PAD). Furthermore, the association between circulating adiponectin levels, fetuin-A, and tumoral necrosis factor-alpha (TNF-α) in patients with atherosclerotic peripheral arterial disease was investigated.
  
  
  METHODS
  Several blood parameters (such as adiponectin, fetuin-A, and TNF-α) were measured in 346 patients, 226 with atherosclerotic peripheral arterial disease (PAD) and 120 without symptomatic PAD (non-PAD). Two common SNPs of the ADIPOQ gene represented by +45T/G 2 and +276G/T were also investigated.
  
  
  RESULTS
  Adiponectin concentrations showed lower circulating levels in the PAD patients compared to non-PAD patients (P < 0.001). Decreasing adiponectin concentration was associated with increasing serum levels of fetuin-A in the PAD patients. None of the investigated adiponectin SNPs proved to be associated with the subjects' susceptibility to PAD (P > 0.05).
  
  
  CONCLUSIONS
  The results of our study demonstrated that neither adiponectin SNP+45 nor SNP+276 is associated with the risk of PAD.
authors.affiliation: Department of Surgery, 2nd Surgical Clinic, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, 4-6 Clinicilor, 400006 Cluj-Napoca, Romania.
authors.forename: Claudia D
authors.initials: CD
authors.lastname: Gherman
authors.forename: Doru
authors.initials: D
authors.lastname: Pamfil
authors.forename: Sorana D
authors.initials: SD
authors.lastname: Bolboacă
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D004587:Electrophoresis, Agar Gel; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015183:Restriction Mapping; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism
chemical_list: D052242:Adiponectin; D014409:Tumor Necrosis Factor-alpha; D060749:alpha-2-HS-Glycoprotein