title: Association between human papillomavirus and endometrial adenocarcinoma.
abstract: Several studies have suggested a possible role of human papillomavirus (HPV) in the pathogenesis of endometrial carcinoma. The aim of the study was to investigate the presence of HPV DNA in endometrium cancers and nonneoplastic endometrium. Sixty endometrial adenocarcinomas with and without squamous differentiation and the nonneoplastic endometrium tissue of fifty-six of the same patients were analyzed for the presence of family 16 and family 6 HPV DNA by using chromogenic in situ hybridization technique on formalin-fixed and paraffin-embedded archival samples, and the results were confirmed by polymerase chain reaction method. HPV DNA was not detected either in the endometrial adenocarcinoma with or without squamous differentiation, or in the nonneoplastic endometrium tissue. It appears that HPV does not play any role in the pathogenesis of endometrial carcinoma, since endometrium may not to be a suitable host for HPV replication.
authors.affiliation: Pathology Department, Dr. Lutfi Kirdar Kartal Research and Training Hospital, Cevizli, Istanbul, Turkey.
authors.forename: Nimet
authors.initials: N
authors.lastname: Karadayi
authors.forename: Melin
authors.initials: M
authors.lastname: Gecer
authors.forename: Sibel
authors.initials: S
authors.lastname: Kayahan
authors.forename: Elif
authors.initials: E
authors.lastname: Yamuc
authors.forename: Nilufer Kandemir
authors.initials: NK
authors.lastname: Onak
authors.forename: Taner
authors.initials: T
authors.lastname: Korkmaz
authors.forename: Dilek
authors.initials: D
authors.lastname: Yavuzer
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology / Q000821:virology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002454:Cell Differentiation / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000235:genetics / Q000473:pathology; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000235:genetics / Q000473:pathology / Q000821:virology*; D014779:Virus Replication / Q000235:genetics
chemical_list: D004279:DNA, Viral