title: Characterization and clinical application of mesenchymal stem cells from equine umbilical cord blood.
abstract: Tendinitis of the superficial digital flexor tendon (SDFT) is a significant cause of lameness in horses; however, recent studies have shown that stem cells could be useful in veterinary regenerative medicine. Therefore, we isolated and characterized equine umbilical cord blood mesenchymal stem cells (eUCB-MSCs) from equine umbilical cord blood obtained from thoroughbred mares during the foaling period. Horses that had tendinitis of the SDFT were treated with eUCB-MSCs to confirm the therapeutic effect. After eUCB-MSCs transplantation, the core lesion in the SDFT was found to decrease. These results suggest that transplantation using eUCB-MSCs could be another source of cell treatment.
authors.affiliation: Department of Veterinary Internal Medicine,Department of Veterinary Public Health, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Korea.
authors.forename: Jun-Gu
authors.initials: JG
authors.lastname: Kang
authors.forename: Sang-Bum
authors.initials: SB
authors.lastname: Park
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Seo
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Kim
authors.forename: Joon-Seok
authors.initials: JS
authors.lastname: Chae
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Kang
mesh_terms: D000818:Animals; D036101:Cord Blood Stem Cell Transplantation / Q000662:veterinary; D006734:Horse Diseases / Q000601:surgery*; D006736:Horses; D008297:Male; D052256:Tendinopathy / Q000601:surgery / Q000662:veterinary*
keywords: cell transplantation; equine; mesenchymal stem cells; umbilical cord blood