title: Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder--a small-sample SPECT study with [¹²³I]ADAM.
abstract: The association between hypothalamo-pituitary-adrenal (HPA) axis function and the serotonergic system could be involved in the mechanism of depression. However, neuroimaging evidence is scarce. The aim of the present study was to probe the association between dexamethasone suppression test response and serotonin transporter (SERT) availability in drug-free patients with major depressive disorder (MDD). Seventeen MDD patients (five males and twelve females) were recruited. SPECT with [(123)I] ADAM was used to measure the midbrain SERT availability, and HPA axis function was measured by the dexamethasone suppression test (DST). The association was significant when considering all participants (ρ=0.69, p=0.002). This association may have clinical implications for the treatment of MDD.
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, Douliou Branch, Yunlin, Taiwan.
authors.forename: Hsin Chun
authors.initials: HC
authors.lastname: Tsai
authors.forename: Shih-Hsien
authors.initials: SH
authors.lastname: Lin
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.forename: Po See
authors.initials: PS
authors.lastname: Chen
authors.forename: Kao Chin
authors.initials: KC
authors.lastname: Chen
authors.forename: Tzung Lieh
authors.initials: TL
authors.lastname: Yeh
authors.forename: Wei Jen
authors.initials: WJ
authors.lastname: Yao
authors.forename: Nan-Tsing
authors.initials: NT
authors.lastname: Chiu
authors.forename: Ru-Band
authors.initials: RB
authors.lastname: Lu
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
mesh_terms: D000328:Adult; D002928:Cinanserin / Q000031:analogs & derivatives; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000378:metabolism*; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging / Q000378:metabolism; D010912:Pituitary-Adrenal Function Tests; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: C413491:2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; D050486:Serotonin Plasma Membrane Transport Proteins; D003907:Dexamethasone; D002928:Cinanserin; D006854:Hydrocortisone
keywords: Dexamethasone suppression test; Major depressive disorder; Serotonin transporter