title: Prevalence and risk factors for carriage of multi-drug resistant Staphylococci in healthy cats and dogs.
abstract: We investigated the distribution of commensal staphylococcal species and determined the prevalence of multi-drug resistance in healthy cats and dogs. Risk factors associated with the carriage of multi-drug resistant strains were explored. Isolates from 256 dogs and 277 cats were identified at the species level using matrix-assisted laser desorption ionisation-time of flight mass spectrometry. The diversity of coagulase-negative Staphylococci (CNS) was high, with 22 species in dogs and 24 in cats. Multi-drug resistance was frequent (17%) and not always associated with the presence of the mecA gene. A stay in a veterinary clinic in the last year was associated with an increased risk of colonisation by multi-drug resistant Staphylococci (OR = 2.4, 95% CI: 1.1~5.2, p value LRT = 0.04). When identifying efficient control strategies against antibiotic resistance, the presence of mechanisms other than methicillin resistance and the possible role of CNS in the spread of resistance determinants should be considered.
authors.affiliation: Cantonal Institute of Microbiology, 6500 Bellinzona, Switzerland. paola.decristophoris@gmail.com.
authors.forename: Paola
authors.initials: P
authors.lastname: Gandolfi-Decristophoris
authors.forename: Gertraud
authors.initials: G
authors.lastname: Regula
authors.forename: Orlando
authors.initials: O
authors.lastname: Petrini
authors.forename: Jakob
authors.initials: J
authors.lastname: Zinsstag
authors.forename: Esther
authors.initials: E
authors.lastname: Schelling
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002371:Cat Diseases / Q000453:epidemiology / Q000382:microbiology*; D002415:Cats; D003030:Coagulase / Q000235:genetics / Q000378:metabolism; D004283:Dog Diseases / Q000453:epidemiology / Q000382:microbiology*; D004285:Dogs; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D012621:Seasons; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000662:veterinary; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D013210:Staphylococcus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D013557:Switzerland / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003030:Coagulase
keywords: antibiotics; coagulase-negative; matrix-assisted laser desorption ionisation-time of flight; staphylococci