title: miR-26a inhibits proliferation and motility in bladder cancer by targeting HMGA1.
abstract: It is increasingly clear that microRNAs play a crucial role in tumorigenesis. Recently, emerging evidence suggested that miR-26a is aberrantly expressed in tumor tissues. In our study, frequent down-regulation of miR-26a was observed in 10 human bladder cancer tissues. Forced expression of miR-26a in the bladder cancer cell line T24 inhibited cell proliferation and impaired cell motility. High mobility group AT-hook 1 (HMGA1), a gene that modulates cell cycle transition and cell motility, was verified as a novel target of miR-26a in bladder cancer. These findings indicate an important role for miR-26a in the molecular etiology of bladder cancer and implicate the potential application of miR-26a in bladder cancer therapy.
authors.affiliation: Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Lin
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Zhenghui
authors.initials: Z
authors.lastname: Hu
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Mao
authors.forename: Xianglai
authors.initials: X
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Shiqi
authors.initials: S
authors.lastname: Li
authors.forename: Qiqi
authors.initials: Q
authors.lastname: Mao
authors.forename: Xiangyi
authors.initials: X
authors.lastname: Zheng
authors.forename: Liping
authors.initials: L
authors.lastname: Xie
mesh_terms: D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation; D015536:Down-Regulation; D016193:G1 Phase; D024003:HMGA Proteins / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D060888:Real-Time Polymerase Chain Reaction; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D024003:HMGA Proteins; D035683:MicroRNAs; C528163:MIRN26 microRNA, human
keywords: Bladder cancer; Cell cycle; HMGA1; High mobility group AT-hook 1; Invasion; MicroRNA; Migration; high mobility group AT-hook 1; miR-26a; miRNA; microRNA