title: Equine-derived bone mineral matrix for maxillary sinus floor augmentation: a clinical, radiographic, histologic, and histomorphometric case series.
abstract: The objective of this proof-of-principle multicenter case series was to examine the bone regenerative potential of a newly introduced equine-derived bone mineral matrix (Equimatrix) to provide human sinus augmentation for the purpose of implant placement in the posterior maxilla. There were 10 patients requiring 12 maxillary sinus augmentations enrolled in this study. Histologic results at 6 months demonstrated abundant amounts of vital new bone in intimate contact with residual graft particles. Active bridging between residual graft particles with newly regenerated bone was routinely observed in intact core specimens. A mean value of 23.4% vital bone formation was observed at 6 months. This compared favorably with previous results using xenografts to produce bone in the maxillary sinus for the purpose of dental implant placement. Both the qualitative and quantitative results of this case series suggest comparable bone regenerative results at 6 months to bovine-derived xenografts.
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Ave., Boston, MA 02115, USA. nevinsperimp@aol.com
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
authors.forename: Friedhelm
authors.initials: F
authors.lastname: Heinemann
authors.forename: Ulrich W
authors.initials: UW
authors.lastname: Janke
authors.forename: Teresa
authors.initials: T
authors.lastname: Lombardi
authors.forename: David
authors.initials: D
authors.lastname: Nisand
authors.forename: Isabella
authors.initials: I
authors.lastname: Rocchietta
authors.forename: Giacomo
authors.initials: G
authors.lastname: Santoro
authors.forename: Peter
authors.initials: P
authors.lastname: Schupbach
authors.forename: David M
authors.initials: DM
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001706:Biopsy / Q000379:methods; D015519:Bone Density / Q000502:physiology; D001853:Bone Marrow / Q000473:pathology; D001857:Bone Matrix / Q000000981:diagnostic imaging / Q000473:pathology / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D064593:Heterografts / Q000000981:diagnostic imaging / Q000473:pathology / Q000637:transplantation*; D006736:Horses; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008437:Maxilla / Q000473:pathology; D008567:Membranes, Artificial; D008875:Middle Aged; D010011:Osteocytes / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D010027:Osteotomy / Q000379:methods; D011859:Radiography; D059546:Sinus Floor Augmentation / Q000379:methods*; D013524:Surgical Flaps / Q000601:surgery; D055815:Young Adult
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; C000589424:equimatrix