title: In vivo evaluation of antiviral compounds on respiratory syncytial virus using a juvenile vervet monkey (Chlorocebus pygerythrus) infection model.
abstract: Several animal models with varying susceptibilities to respiratory syncytial virus (RSV) infection have been developed to study the specific aspects of RSV disease. Many of these models are used for testing antiviral compounds or in vaccine efficacy studies during preclinical evaluation. In this chapter, we describe the study design of an efficacy study of an RSV inhibitor, performed in a juvenile vervet monkey model for RSV.
authors.affiliation: Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
authors.forename: Lieselot
authors.initials: L
authors.lastname: Houspie
authors.forename: Hans
authors.initials: H
authors.lastname: Stevens
authors.forename: Maina
authors.initials: M
authors.lastname: Ngotho
authors.forename: Els
authors.initials: E
authors.lastname: Keyaerts
authors.forename: Gabriela
authors.initials: G
authors.lastname: Ispas
authors.forename: René
authors.initials: R
authors.lastname: Verloes
authors.forename: Marc
authors.initials: M
authors.lastname: Van Ranst
authors.forename: Piet
authors.initials: P
authors.lastname: Maes
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D006801:Humans; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy* / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000187:drug effects* / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019562:Viral Load; D010948:Viral Plaque Assay
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral