title: Cancer diagnosis and prognosis decoded by blood-based circulating microRNA signatures.
abstract: In the recent years, circulating microRNAs (miRNAs) have garnered a lot of attention and interest in the field of disease biomarkers. With characteristics such as high stability, low cost, possibility of repeated sampling and minimal invasiveness, circulating miRNAs are ideal for development into diagnostic tests. There have been many studies reported on the potential of circulating miRNAs as early detection, prognostic, and predictive biomarkers in cancer. Here, we have reviewed the application of plasma and serum miRNAs as biomarkers for cancer focusing on epithelial carcinomas [prostate, breast, lung, colorectal, and gastric cancer (GC)] and hematological malignancies (leukemia and lymphoma). We have also addressed the common challenges that need to be overcome to achieve a successful bench to bedside transition.
authors.affiliation: Molecular Epidemiology, German Cancer Research Center Heidelberg, Germany ; Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University Clinic Heidelberg, Heidelberg, Germany.
authors.forename: Dharanija
authors.initials: D
authors.lastname: Madhavan
authors.forename: Katarina
authors.initials: K
authors.lastname: Cuk
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
authors.forename: Rongxi
authors.initials: R
authors.lastname: Yang
keywords: biomarkers; cancer; circulating miRNA; detection marker; prognostic marker