title: Ethosomes as delivery system for transdermal administration of vinpocetine.
abstract: The purpose of the present study was to develop a novel transdermal vinpocetine patch containing a stable formulation and with good entrapment efficiency, and percutaneous absorption which via ethosome. Ethosome was found to be a more efficient delivery carrier with high encapsulation capacities (79.5% +/- 1.8%) and nanometric size (180.7 +/- 1.5 nm). In vitro percutaneous permeation experiments demonstrated that the permeation of vinpocetine through abdominal skin of Sprague Dawley was significantly increased when ethosome was used. The vinpocetine transdermal fluxes from ethosome gel (3.56 +/- 0.13 microg/cm2/h) were 6.72 and 3.10 times higher than that of vinpocetine gel solution and vinpocetine aueous solution, respectively. Furthermore, the AUC(0 --> infinity), and eliminiation half-life by the transdermal administration were significantly higher than those by the intragastric administration (P < 0.01). The study demonstrated that ethosome is a promising vesicular carrier for enhancing percutaneous absorption of vinpocetine.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China.
authors.forename: Yan-Ting
authors.initials: YT
authors.lastname: Mao
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Hua
authors.forename: Xiang-Guo
authors.initials: XG
authors.lastname: Zhang
authors.forename: Dong-Xue
authors.initials: DX
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Gui
authors.forename: Yong-Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005782:Gels; D066298:In Vitro Techniques; D007441:Intubation, Gastrointestinal; D008081:Liposomes / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012996:Solutions; D014748:Vinca Alkaloids / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000959:Antihypertensive Agents; D004337:Drug Carriers; D005782:Gels; D008081:Liposomes; D012996:Solutions; D014748:Vinca Alkaloids; C013983:vinpocetine