title: [Cytoplasmic expression of P27 protein and its correlation with clinicopathologic features of nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To evaluate the correlation of p27 protein expression in the cytoplasm with the clinicopathologic features of nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  Immunohistochemistry was employed to examine P27 protein expression in the cytoplasm of NPC samples and nasopharyngeal (NP) tissue samples. The differential expression of P27 protein between NPCs and NPs and the correlation of cytoplasmic P27 protein expression with the clinicopathologic parameters of NPC patients was analyzed. RESULTS Immunohistochemistry indicated significantly down-regulated t p27 protein expression in NPC tissues compared to that in NP tissues (P=0.047). The reduction of P27 expression was inversely correlated with T classification of NPC (P=0.033). Although cytoplasmic p27 protein expression was not significantly correlated with lymph node metastasis (P=0.157) or clinical stages of NPC (P=0.090), an obvious trend of inverse correlations between them was noted.
  
  
  CONCLUSIONS
  Down-regulated cytoplasmic p27 protein expression may promote the carcinogenesis of NPC and can be an unfavorable prognostic factor for survival of NPC patients.
authors.affiliation: Cancer Research Institute, Southern Medical University, Guangzhou 510515, China. 191453255@qq.com
authors.forename: Wei
authors.initials: W
authors.lastname: Hang
authors.forename: Shijun
authors.initials: S
authors.lastname: Sun
authors.forename: Yijing
authors.initials: Y
authors.lastname: Ye
authors.forename: Weiyi
authors.initials: W
authors.lastname: Fang
mesh_terms: D002277:Carcinoma; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis
chemical_list: D050760:Cyclin-Dependent Kinase Inhibitor p27