title: Synthesis and antifungal activities of 2-(N-arylsulfonylindol-3-yl)-3-aryl-1,3-thiazinan-4-ones.
abstract: A series of 2-(N-arylsulfonylindol-3-yl)-3-aryl-1,3-thiazinan-4-one derivatives were synthesized and evaluated in vitro against seven phytopathogenic fungi, namely Fusarium graminearum, Alternaria solani, Fusarium oxysporium f. sp. vasinfectum, Alternaria brassicae, Valsa mali, Alternaria alternata, and Pyricularia oryzae. Among all derivatives, especially compound 4j exhibited a potential antifungal activity against four phytopathogenic fungi.
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A & F University, Yangling 712100, PR China.
authors.forename: Huan
authors.initials: H
authors.lastname: Qu
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Yazhen
authors.initials: Y
authors.lastname: Ke
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Gao
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000145:classification / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D021241:Spectrometry, Mass, Electrospray Ionization; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D013843:Thiazines