title: Late primary arterial switch for transposition of the great arteries with intact ventricular septum in an african population.
abstract: The arterial switch operation (ASO) is the optimal management of transposition of the great arteries with intact ventricular septum (TGA-IVS) within the first 3 weeks of life; beyond this age optimal treatment is debatable. The authors adopted a strategy of primary ASO for TGA-IVS in the first 10 weeks of life regardless of left ventricular (LV) status. This report reviews the early outcomes with this management approach. Between August 2006 and December 2009, 22 patients with TGA-IVS underwent the primary ASO. Sixteen of them were less than 21 days old (early switch group) and 6 were between 31 and 66 days old (late switch group). A review of their hospital records was performed to determine outcomes in the 2 groups. Operative variables and postoperative outcomes were recorded. There was 1 hospital death in the early switch group (6.3%) but none in the late group (0%). Temporary mechanical circulatory support was required in 1 patient (6.3%) in the early switch group and in 2 of the 6 (33.3%) in the late switch group. One late death of undetermined cause occurred in the late switch group 8 weeks after discharge. No significant difference could be demonstrated between the 2 groups in terms of operative variables and the measured postoperative outcomes. It is concluded that the age limit for the primary ASO can be extended to at least 10 weeks; temporary mechanical circulatory support may be required as a rescue.
authors.affiliation: Walter Sisulu Pediatric Cardiac Center for Africa, Johannesburg, South Africa.
authors.forename: Frank
authors.initials: F
authors.lastname: Edwin
authors.forename: Robin H
authors.initials: RH
authors.lastname: Kinsley
authors.forename: Johann
authors.initials: J
authors.lastname: Brink
authors.forename: Greg
authors.initials: G
authors.lastname: Martin
authors.forename: Hendrick
authors.initials: H
authors.lastname: Mamorare
authors.forename: Peter
authors.initials: P
authors.lastname: Colsen
keywords: arterial switch operation; mortality; transposition; ventricular septum