title: The XRCC3 Thr241Met polymorphism influences glioma risk - a meta-analysis.
abstract: BACKGROUND
  Findings from previous published studies regarding the association of the XRCC3 Thr241Met polymorphism with glioma susceptibility have often been conflicting. Therefore, a meta-analysis including all available publications was carried out to make a more precise estimation of the potential relationship.
  
  
  METHODS
  By searching the electronic databases of Pubmed and Embase (up to April 1st, 2013), a total of nine case-control studies with 3,752 cases and 4,849 controls could be identified for inclusion in the current meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association.
  
  
  RESULTS
  This meta-analysis showed the XRCC3 Thr241Met polymorphism to be significantly associated with decreased glioma risk in the allelic model (Met allele vs. Thr allele: OR= 0.708, 95%CI= 0.631-0.795). Moreover, we also observed a statistically significant association between the XRCC3 Thr241Met polymorphism and reduced glioma risk in analyses stratified by ethnicity (Asian) and source of controls (hospital based) in the allelic model.
  
  
  CONCLUSIONS
  Current evidence suggests that the XRCC3 Thr241Met polymorphism may be a risk factor for glioma development, especially in Asians.
authors.affiliation: Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.forename: Xun-Feng
authors.initials: XF
authors.lastname: Quan
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3