title: The catechol-o-methyltransferase Val158 Met polymorphism modulates organization of regional cerebral blood flow response to working memory in adults.
abstract: This study examined the effect of catechol-o-methyltransferase (COMT) Val(158)Met genotypes on the co-activation of brain areas involved in cognition during a working memory (WM) task. The pattern of concomitant region of interest (ROI) activation during WM performance varied by genotype: Val/Val showing the least and Met/Met the most covariance. There were no differences of performance on the WM task between the COMT genotypes. However, relatively better performance was associated with less concomitance of dorsolateral prefrontal cortex (DLPFC) and cingulate cortex for Val/Val, but more concomitance of DLPFC with AH for Met/Met. Within genotypes WM performance was significantly correlated with rCBF to the amygdala/hippocampus (AH) for Val/Val (r = 0.44, p = 0.009), to the parietal lobe for Val/Met (r = 0.29, p = 0.03), and to the thalamus for Met/Met (r = 0.32, p = 0.04). Different genotypes showed different regional specificity and concomitant activation patterns suggesting that varying dopamine availability induces different brain processing pathways to achieve similar WM performance.
authors.affiliation: TDH E-1329 Psychophysiology Lab, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: heimaf@upmc.edu.
authors.forename: Alicia F
authors.initials: AF
authors.lastname: Heim
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Coyne
authors.forename: M Ilyas
authors.initials: MI
authors.lastname: Kamboh
authors.forename: Christopher
authors.initials: C
authors.lastname: Ryan
authors.forename: J Richard
authors.initials: JR
authors.lastname: Jennings
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000235:genetics* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D010775:Photic Stimulation; D011110:Polymorphism, Genetic; D049268:Positron-Emission Tomography; D011594:Psychometrics; D014633:Valine / Q000235:genetics
chemical_list: D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine
keywords: AH; COMT; Catechol-o-methyltransferase (COMT); DA; DLPFC; Dopamine; PET; ROI; WM; Working memory; amygdala/hippocampus; catechol-o-methyltransferase; dopamine; dorsolateral prefrontal cortex; region of interest; working memory