title: Structural synaptic plasticity in the hippocampus induced by spatial experience and its implications in information processing.
abstract: BACKGROUND
  Long-lasting memory formation requires that groups of neurons processing new information develop the ability to reproduce the patterns of neural activity acquired by experience.
  
  
  METHODS
  Changes in synaptic efficiency let neurons organise to form ensembles that repeat certain activity patterns again and again. Among other changes in synaptic plasticity, structural modifications tend to be long-lasting which suggests that they underlie long-term memory. There is a large body of evidence supporting that experience promotes changes in the synaptic structure, particularly in the hippocampus.
  
  
  CONCLUSIONS
  Structural changes to the hippocampus may be functionally implicated in stabilising acquired memories and encoding new information.
authors.affiliation: Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología (INB), Campus UNAM-Juriquilla, Querétaro, México.
authors.forename: M
authors.initials: M
authors.lastname: Carasatorre
authors.affiliation: Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología (INB), Campus UNAM-Juriquilla, Querétaro, México.
authors.forename: V
authors.initials: V
authors.lastname: Ramírez-Amaya
authors.affiliation: Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología (INB), Campus UNAM-Juriquilla, Querétaro, México. Electronic address: yoldi@unam.mx.
authors.forename: S
authors.initials: S
authors.lastname: Díaz Cintra
mesh_terms: D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D057567:Memory, Long-Term; D008606:Mental Processes / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*
keywords: Ensambles neuronales; Experiencia espacial; Fibras musgosas; Hipocampo; Hippocampus; Long-term memory; Memoria a largo plazo; Mossy fibres; Neuronal ensembles; Plasticidad sináptica; Spatial experience; Synaptic plasticity