title: [The unification of physical chemical and biological actions of spirits of glycerin and cholesterol in cell's absorption of fatty acids: the singularity of pathogenesis of "metabolic pandemics"].
abstract: According to phylogenetic theory of pathology, atherosclerosis is a syndrome of deficiency of essential polyene fatty acids in cells. The unfavorable impact of environment and derangement of biological function of trophology (function of nutrition) results in failure of transfer in the structure of lipoproteins and their active absorption by cells and metabolism of lipids and fatty acids. All these processes were formed billions years in the past at the autocrine (cell) level, in paracrine cenosis of cells and at the level of organism. The apparent derangements of trophology "highlight" the regular and metabolic limitations (hidden "defects") which derange bioavailability of essential polyene fatty acids for cells by blocking cells' active absorption. The processes of metabolism of nonpolar ethers of fatty acids with spirits of glycerin and cholesterol are impacted too. The biological function of intelligence applied the biological modes can eliminate this derangement through development of theory of pathogenesis of atherosclerosis and its effective prevention. The normalization of biological function of trophology and brining to conformity with capacities of organism advanced in phylogenesis are the only effective mode of prevention. This approach will decrease at once the prevalence of all "metabolic pandemics" in population. The spirit cholesterol will continue to occupy a fitting position in diagnostics of atherosclerosis on a par with spirit glycerin with identification of triglycerides. Both spirits are of equal value as diagnostic tests to detect the failure of transfer in the structure of lipoproteins and active receptor absorption of fatty acids by cells. The article proposes to unify on the basis of pathogenesis all "metabolic pandemics", diabetes mellitus included, into the section of clinical medicine and name it "pathology of fatty acids".
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism / Q000503:physiopathology; D019898:Autocrine Communication / Q000502:physiology; D002784:Cholesterol / Q000378:metabolism*; D005228:Fatty Acids, Essential / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism* / Q000503:physiopathology; D008962:Models, Theoretical; D019899:Paracrine Communication / Q000502:physiology; D017539:Tunica Intima / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D005228:Fatty Acids, Essential; D008074:Lipoproteins; D002784:Cholesterol