title: Contrast-enhanced MR enterography as a stand-alone tool to evaluate Crohn's disease in a paediatric population.
abstract: OBJECTIVE
  To assess the performance of contrast-enhanced T1-weighted magnetic resonance imaging (MRI) alone in the evaluation of Crohn's disease in comparison to all magnetic resonance enterography (MRE) imaging sequences together in an attempt to suggest limitation of the number of overall unenhanced sequences need for the follow-up evaluation.
  
  
  METHODS
  Twenty-five paediatric patients (mean age 14.1 ± 3.7 years, male = 12, female = 13) underwent MRE at 1.5 T for evaluation of Crohn's disease. Two radiologists reviewed only contrast-enhanced T1-weighted images in consensus on the first session. Whole images including unenhanced (steady-state free precession, single-shot fast spin-echo (HASTE), fat-suppressed T2-weighted) and contrast-enhanced T1-weighted sequences were reviewed in consensus during the second session with a 1 month interval, which was used as a reference standard. The readers evaluated the presence or absence of disease in 10 bowel segments in each patient. For the abnormal bowel segments, the readers then evaluated for active versus inactive disease and for the presence or absence of abscess. Sensitivity, specificity, and overall accuracy were calculated for detecting active inflammation.
  
  
  RESULTS
  There were 53/250 bowel segments with active inflammation using the reference standard imaging method. The sensitivity, specificity, and accuracy for diagnosing active inflammation using contrast-enhanced images alone were 83.3%, 86.9%, and 84.9%. In five of the false-positive cases of detecting abscess from contrast-enhanced imaging alone, absence of abscesses was confirmed on the non-fat-suppressed HASTE images.
  
  
  CONCLUSIONS
  The number of MRE sequences in paediatric Crohn's patients can be decreased while maintaining diagnostic accuracy using contrast-enhanced T1 and non-fat-suppressed HASTE images.
authors.affiliation: Department of Radiology, NYU Langone Medical Center, New York, NY, USA.
authors.forename: B
authors.initials: B
authors.lastname: Spieler
authors.forename: N
authors.initials: N
authors.lastname: Hindman
authors.forename: J
authors.initials: J
authors.lastname: Levy
authors.forename: K
authors.initials: K
authors.lastname: Zabrieski
authors.forename: D
authors.initials: D
authors.lastname: Sahlein
authors.forename: C
authors.initials: C
authors.lastname: Seuss
authors.forename: S
authors.initials: S
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D002648:Child; D003287:Contrast Media; D003424:Crohn Disease / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA