title: Military risk factors for Alzheimer's disease.
abstract: Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.
authors.affiliation: San Francisco Veterans Administration Medical Center, San Francisco, CA, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Weiner
authors.forename: Karl E
authors.initials: KE
authors.lastname: Friedl
authors.forename: Anthony
authors.initials: A
authors.lastname: Pacifico
authors.forename: Julie C
authors.initials: JC
authors.lastname: Chapman
authors.forename: Michael S
authors.initials: MS
authors.lastname: Jaffee
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Little
authors.forename: Geoffrey T
authors.initials: GT
authors.lastname: Manley
authors.forename: Ann
authors.initials: A
authors.lastname: McKee
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: Roger K
authors.initials: RK
authors.lastname: Pitman
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.forename: Robert
authors.initials: R
authors.lastname: Obana
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Bain
authors.forename: Maria C
authors.initials: MC
authors.lastname: Carrillo
mesh_terms: D055826:Afghan Campaign 2001-; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D015415:Biomarkers; D001753:Blast Injuries / Q000453:epidemiology / Q000523:psychology; D001925:Brain Damage, Chronic / Q000453:epidemiology / Q000209:etiology; D001930:Brain Injuries / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D016208:Databases, Factual / Q000706:statistics & numerical data; D042241:Early Diagnosis; D006078:Government Programs / Q000379:methods / Q000458:organization & administration; D006801:Humans; D054542:Iraq War, 2003-2011; D008887:Military Medicine / Q000458:organization & administration; D008889:Military Personnel / Q000523:psychology / Q000706:statistics & numerical data; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D055825:National Institute of Neurological Disorders and Stroke (U.S.); D059906:Neuroimaging; D012307:Risk Factors; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology / Q000523:psychology; D014481:United States; D059030:United States Department of Defense / Q000458:organization & administration; D014493:United States Department of Veterans Affairs / Q000458:organization & administration; D058014:Veterans Health / Q000706:statistics & numerical data
chemical_list: D015415:Biomarkers