title: Photo-crosslinked poly(ethylene glycol)-b-poly(ϵ-caprolactone) nanoparticles for controllable paclitaxel release.
abstract: Novel biodegradable core-crosslinked nanoparticles (CNPs) consisting of methoxy poly(ethylene glycol)-block-poly(ϵ-caprolactone-co-γ-cinnamoyloxy-ϵ-caprolactone) (mPEG-b-P(CL-co-CCL)) were prepared and evaluated for paclitaxel (PTX) delivery. mPEG113-b-P(CL65.2-co-CCL10.1) had a higher drug loading efficiency (95%) compared to mPEG113-b-PCL93.1 (43%). The stability of NPs has been largely improved and PTX release was significantly inhibited by crosslinking via UV irradiation at λ = 254 nm. MTT assays demonstrated that both blank non-crosslinked and crosslinked NPs showed low cytotoxicity to NCL-H460 cells while PTX-loaded non-crosslinked and crosslinked NPs exhibited obvious cytotoxicity against NCL-H460 cells, and the cytotoxicity was both dose-dependent and time-dependent. Furthermore, after 48 h incubation the cell viability of PTX-loaded crosslinked NPs was lower compared to that of PTX-loaded non-crosslinked NPs or free PTX. These properties indicated that CNPs prepared from mPEG-b-P(CL-co-CCL) have great potentials as carriers for drug delivery.
authors.affiliation: a School of Chemical Engineering and Technology, Tianjin University , Tianjin , 300072 , China.
authors.forename: Longlong
authors.initials: L
authors.lastname: Chang
authors.forename: Weiwei
authors.initials: W
authors.lastname: Wang
authors.forename: Pingsheng
authors.initials: P
authors.lastname: Huang
authors.forename: Zesheng
authors.initials: Z
authors.lastname: Lv
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Hu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.forename: Deling
authors.initials: D
authors.lastname: Kong
authors.forename: Liandong
authors.initials: L
authors.lastname: Deng
authors.forename: Anjie
authors.initials: A
authors.lastname: Dong
mesh_terms: D002460:Cell Line; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D004356:Drug Storage; D005026:Ethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D017239:Paclitaxel / Q000737:chemistry*; D010316:Particle Size; D055668:Photochemical Processes; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D014466:Ultraviolet Rays
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005026:Ethylene Glycols; D008823:Micelles; D011091:Polyesters; C476300:poly(epsilon-caprolactone)-b-poly(ethylene glycol); D017239:Paclitaxel