title: Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis.
abstract: Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.
authors.affiliation: Gray Institute for Radiation Oncology and Biology; University of Oxford; Oxford, UK.
authors.forename: Su Yin
authors.initials: SY
authors.lastname: Lim
authors.forename: Alex N
authors.initials: AN
authors.lastname: Gordon-Weeks
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Tapmeier
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Im
authors.forename: Yunhong
authors.initials: Y
authors.lastname: Cao
authors.forename: John
authors.initials: J
authors.lastname: Beech
authors.forename: Danny
authors.initials: D
authors.lastname: Allen
authors.forename: Sean
authors.initials: S
authors.lastname: Smart
authors.forename: Ruth J
authors.initials: RJ
authors.lastname: Muschel
keywords: CCL2; colon cancer; liver metastasis; myeloid cell recruitment