title: Development of a new strategy of visual field testing for macular dysfunction in patients with open angle glaucoma.
abstract: OBJECTIVE
  To explore methods of automated visual field (VF) examination for the assessment of macular function.
  
  
  METHODS
  We used a VF examination (AP-7000 automatic perimeter, Kowa, Japan) to examine macular function in 53 eyes from 29 patients with open angle glaucoma. We measured the mean total deviation (c-MD) of 16 points in the central VF located in a 2-degree-interval 4 × 4 array with various stimulus sizes (Goldmann sizes III, II, and I). The retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC), and ganglion cell layer plus inner plexiform layer (GCL + IPL) were measured with the 3D OCT-2000 System (Topcon, Japan). The c-MDs of various stimulus sizes were compared with the OCT parameters using the Spearman rank correlation.
  
  
  RESULTS
  The average examination time was 93.5 ± 23.5 s and the c-MD values were -11.8 ± 8.2 (stimulus size III), -11.9 ± 9.5 (stimulus size II), and -12.3 ± 9.6 dB (stimulus size I). The c-MD (stimulus size III) and averaged total deviations of the Humphrey Field Analysis 10-2 program were significantly correlated (ρ = 0.91). The C-MD values for stimulus size III were significantly correlated with the OCT parameters (RNFL: ρ = 0.59; GCC: ρ = 0.65; and GCL + IPL: ρ = 0.64). The correlation coefficient between the c-MD and the GCC was better for stimulus sizes II and I (ρ = 0.69) than for stimulus size III (ρ = 0.65).
  
  
  CONCLUSIONS
  The C-MD values for the 16 measured central VF points were significantly correlated with macular structure, and the smaller stimulus sizes of the automated VF test had a higher correlation coefficient of within 8°.
authors.affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Omodaka
authors.forename: Shiho
authors.initials: S
authors.lastname: Kunimatsu-Sanuki
authors.forename: Ryu
authors.initials: R
authors.lastname: Morin
authors.forename: Satoru
authors.initials: S
authors.lastname: Tsuda
authors.forename: Yu
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kazuichi
authors.initials: K
authors.lastname: Maruyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunikata
authors.forename: Toru
authors.initials: T
authors.lastname: Nakazawa
mesh_terms: D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests; D014794:Visual Fields