title: Solid pseudopapillary tumor of the pancreas: a case series of 9 patients.
abstract: OBJECTIVE
  Solid pseudopapillary tumor is a rare exocrine tumor of the pancreas. There is no clear consensus on its etiology, origin and treatment. In this study, the clinical, pathological and immunohistochemical features of nine patients with solid pseudopapillary tumor were re-evaluated in view of the current literature findings.
  
  
  METHODS
  We studied nine cases diagnosed with solid pseudopapillary tumor between 2005 and 2010. The clinical, pathological and laboratory data were analyzed.
  
  
  RESULTS
  On microscopy, all tumors had well-defined borders and were separated from surrounding pancreatic tissue by a thick fibrous capsule. The tumor consisted mainly of pseudopapillary structures with focal solid areas accompanied by wide hemorrhagic and cystic regions. The typical morphological features were present to varying degrees. Of the nine cases, one relapsed approximately two years after the diagnosis, and our laboratory also evaluated the surgical specimen of local recurrence.
  
  
  CONCLUSIONS
  While some new light has been shed on the clinicopathological features of solid pseudopapillary tumor concerning its etiology, origin and treatment methods, there is much to be understood. Further studies focusing on genetics, pathogenesis and prognosis are needed for a better understanding of this entity.
authors.affiliation: HaydarpaŞa Numune Education and Research Hospital, Department of Pathology, İstanbul. selvinazo@gmail.com
authors.forename: Selvinaz
authors.initials: S
authors.lastname: Özkara
authors.forename: Fügen
authors.initials: F
authors.lastname: Vardar Aker
authors.forename: Ali
authors.initials: A
authors.lastname: Yıtık
authors.forename: İlkay
authors.initials: İ
authors.lastname: Tosun
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sağla
authors.forename: Züleyha
authors.initials: Z
authors.lastname: Akkan Cetınkaya
authors.forename: Gülistan
authors.initials: G
authors.lastname: Gümrükçü
authors.forename: Nesime
authors.initials: N
authors.lastname: Tısgaoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology*; D003536:Cystadenocarcinoma / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000175:diagnosis / Q000473:pathology; D006470:Hemorrhage / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult