title: HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype.
abstract: OBJECTIVE
  The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women.
  
  
  METHODS
  Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women.
  
  
  METHODS
  We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS.
  
  
  RESULTS
  The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Z  =  -3.60, P  < 0.001.
  
  
  CONCLUSIONS
  We report the novel finding of an association between the Val158Met genotype and HIV serostatus that may be mediated through the impact of dopamine function on propensity for risk-taking.
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Sundermann
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Bishop
authors.forename: Leah H
authors.initials: LH
authors.lastname: Rubin
authors.forename: Bradley
authors.initials: B
authors.lastname: Aouizerat
authors.forename: Tracey E
authors.initials: TE
authors.lastname: Wilson
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Weber
authors.forename: Mardge
authors.initials: M
authors.lastname: Cohen
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Golub
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
authors.forename: Chenglong
authors.initials: C
authors.lastname: Liu
authors.forename: Howard
authors.initials: H
authors.lastname: Crystal
authors.forename: Celeste L
authors.initials: CL
authors.lastname: Pearce
authors.forename: Pauline M
authors.initials: PM
authors.lastname: Maki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012309:Risk-Taking; D055815:Young Adult
chemical_list: D002394:Catechol O-Methyltransferase