title: 6-[3-(p-Tolyl-sulfonyl-amino)-prop-yl]diquino-thia-zine.
abstract: In the title mol-ecule {systematic name: N-[3-(diquino[3,2-b;2',3'-e][1,4]thia-zin-6-yl)prop-yl]-4-methyl-benzene-sulfon-amide}, C28H24N4O2S2, the penta-cyclic system is relatively planar [maximum deviation from the mean plane = 0.242 (1) Å]. The dihedral angle between two quinoline ring systems is 8.23 (2)° and that between the two halves of the 1,4-thia-zine ring is 5.68 (3)°. The conformation adopted by the 3-(p-tolyl-sulfonyl-amino)-propyl substituent allows for the formation of an intra-molecular N-H⋯N hydrogen bond and places the benzene ring of this substituent above one of the quinoline fragments of the penta-cyclic system. In the crystal, mol-ecules are arranged via π-π stacking inter-actions into (0-11) layers [centroid-centroid distances = 3.981 (1)-4.320 (1) Å for the rings in the penta-cyclic system and 3.645 (1) Å for the tolyl benzene rings]. In addition, mol-ecules are involved in weak C-H⋯O, which connect the layers, and C-H⋯S hydrogen bonds. The title compound shows promising anti-cancer activity against renal cancer cell line UO-31.
authors.affiliation: Department of Organic Chemistry, The Medical University of Silesia, ul. Jagiellońska 4, PL-41 200 Sosnowiec, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Jeleń
authors.forename: Aleksander
authors.initials: A
authors.lastname: Shkurenko
authors.forename: Kinga
authors.initials: K
authors.lastname: Suwińska
authors.forename: Krystian
authors.initials: K
authors.lastname: Pluta
authors.forename: Beata
authors.initials: B
authors.lastname: Morak-Młodawska