title: Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat.
abstract: The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9% normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.
authors.affiliation: College of Pharmacy and Biological Science, Weifang Medical University, 7166# Baotong Road, Weifang, 261053, People's Republic of China.
authors.forename: Zengjuan
authors.initials: Z
authors.lastname: Zheng
authors.forename: Weifen
authors.initials: W
authors.lastname: Zhang
authors.forename: Weiqing
authors.initials: W
authors.lastname: Sun
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Li
authors.forename: Jinghua
authors.initials: J
authors.lastname: Duan
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Cui
authors.forename: Zhanqin
authors.initials: Z
authors.lastname: Feng
authors.forename: Heidi M
authors.initials: HM
authors.lastname: Mansour
mesh_terms: D000818:Animals; D048271:Chitosan / Q000031:analogs & derivatives* / Q000494:pharmacology; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D010532:Peritoneal Diseases / Q000378:metabolism / Q000517:prevention & control*; D011183:Postoperative Complications; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D000267:Tissue Adhesions / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D012996:Solutions; C514968:carboxymethyl-chitosan; D048271:Chitosan; D006909:Hydroxyproline