title: Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy.
abstract: The use of human umbilical cord blood-derived mesenchymal stem cells for cell transplantation therapy holds great promise for repairing spinal cord injury. Here we report the first clinical trial transplantation of human umbilical cord (hUCB)-derived mesenchymal stem cells (MSCs) into the spinal cord of a dog suspected to have fibrocartilaginous embolic myelopathy (FCEM) and that experienced a loss of deep pain sensation. Locomotor functions improved following transplantation in a dog. Based on our findings, we suggest that transplantation of hUCB-derived MSCs will have beneficial therapeutic effects on FCEM patients lacking deep pain sensation.
authors.affiliation: Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
authors.forename: Wook-Hun
authors.initials: WH
authors.lastname: Chung
authors.forename: Seon-Ah
authors.initials: SA
authors.lastname: Park
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Dai-Jung
authors.initials: DJ
authors.lastname: Chung
authors.forename: Wo-Jong
authors.initials: WJ
authors.lastname: Yang
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Kang
authors.forename: Chi-Bong
authors.initials: CB
authors.lastname: Choi
authors.forename: Hwa-Seok
authors.initials: HS
authors.lastname: Chang
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Soo-Han
authors.initials: SH
authors.lastname: Hwang
authors.forename: Hoon
authors.initials: H
authors.lastname: Han
authors.forename: Hwi-Yool
authors.initials: HY
authors.lastname: Kim
mesh_terms: D000818:Animals; D002357:Cartilage Diseases / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D036101:Cord Blood Stem Cell Transplantation / Q000662:veterinary; D004283:Dog Diseases / Q000209:etiology / Q000628:therapy*; D004285:Dogs; D004617:Embolism / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D005260:Female; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D013118:Spinal Cord Diseases / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D016896:Treatment Outcome
keywords: dog; fibrocartilaginous embolic myelopathy; human umbilical cord-derived mesenchymal stem cells; percutaneous transplantation; xenotransplantaion