title: Two cases of acute erythroid leukemia presenting with marked macrocytic anemia, reticulocytosis and hemolysis.
abstract: Case 1. The laboratory findings of a hematological analysis of a 53-year-old woman with palpitations and dyspnea revealed the following: red blood cell (RBC) count: 9.4×10(5)/μL with 60.0‰ reticulocytes; Hb: 3.7 g/dL; mean corpuscular volume (MCV): 124.5 fL; white blood cell (WBC) count: 2,800/μL with 10.0% myeloblasts. Case 2. Similarly, a 42-year-old man with dizziness had a RBC count of 1.63×10(6)/μL with 24.0% reticulocytes, an Hb level of 6.0 g/dL, an MCV of 120.2 fL and a WBC count of 3,100/μL with 4.0% myeloblasts. Bone marrow aspirates in both patients confirmed a diagnosis of acute erythroid leukemia (AEL), which can present as marked macrocytic anemia with an MCV in excess of 120 fL and hemolysis.
authors.affiliation: Department of Internal Medicine, Himeji St. Mary's Hospital, Japan. seisukeota@mail.goo.ne.jp
authors.forename: Seisuke
authors.initials: S
authors.lastname: Ota
authors.forename: Akinori
authors.initials: A
authors.lastname: Kasahara
authors.forename: Shoma
authors.initials: S
authors.lastname: Mizuno
authors.forename: Osamu
authors.initials: O
authors.lastname: Uchikoga
authors.forename: Momoko
authors.initials: M
authors.lastname: Kuroda
authors.forename: Haruka
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Kohei
authors.initials: K
authors.lastname: Shiomi
authors.forename: Sachio
authors.initials: S
authors.lastname: Umena
authors.forename: Toshio
authors.initials: T
authors.lastname: Noguchi
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Kishimoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsumura
mesh_terms: D000328:Adult; D000748:Anemia, Macrocytic / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006461:Hemolysis / Q000502:physiology*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D045262:Reticulocytosis / Q000502:physiology*