title: Determinants of high sensitivity troponin T concentration in chronic stable patients with heart failure: Ischemic heart failure versus non-ischemic dilated cardiomyopathy.
abstract: BACKGROUND
  Cardiac troponin T is a marker of myocardial injury, especially when measured by means of the high-sensitivity assay (hs-cTnT). The echocardiographic and clinical predictors of hs-cTnT may be different in ischemic heart failure (IHF) and non-ischemic dilated cardiomyopathy (DCM).
  
  
  METHODS
  Sixty consecutive patients (19 female, 41 male; mean age 56.3 ± 13.9 years) with stable congestive heart failure (33 patient with IHF and 27 patients with DCM), with New York Heart Association functional class I-II symptoms, and left ventricular ejection fraction < 40% were included.
  
  
  RESULTS
  In patients with IHF peak early mitral inflow velocity (E), E/peak early diastolic mitral annular tissue Doppler velocity (Em) lateral, peak systolic mitral annular tissue Doppler velocity (Sm) lateral and logBNP were univariate predictors of hs-cTnT above median. But only E/Em lateral was an independent predictor of hs-cTnT above median (p = 0.04, HR: 1.2,CI: 1-1.4). In patients with DCM; left atrial volume index, male sex, Sm lateral and global longitudinal strain (LV-GLS) were included in multivariate model and LV-GLS was detected to be an independent predictor for hs-cTnT above median (p < 0.05, HR: 0.7, CI: 0.4-1.0).
  
  
  CONCLUSIONS
  While LV-GLS is an independent predictor of hs-cTnT concentrations in patients with DCM, E/Em lateral predicted hs-TnT concentrations in patients with IHF.
authors.affiliation: Kartal Kosuyolu Heart and Research Hospital, Istanbul, Turkey. rukenbengi@gmail.com.
authors.forename: Ruken Bengi
authors.initials: RB
authors.lastname: Bakal
authors.forename: Suzan
authors.initials: S
authors.lastname: Hatipoglu
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kahveci
authors.forename: Mehmet Onur
authors.initials: MO
authors.lastname: Omaygenc
authors.forename: Tuba
authors.initials: T
authors.lastname: Unkun
authors.forename: Taylan
authors.initials: T
authors.lastname: Akgun
authors.forename: Muslum
authors.initials: M
authors.lastname: Sahin
authors.forename: Ali
authors.initials: A
authors.lastname: Elveran
authors.forename: Olcay
authors.initials: O
authors.lastname: Ozveren
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozdemir
mesh_terms: D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D015150:Echocardiography, Doppler; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D011379:Prognosis; D013318:Stroke Volume; D020107:Troponin T / Q000097:blood*; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D015415:Biomarkers; D020107:Troponin T