title: CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease.
abstract: Coronary heart disease (CHD), the leading cause of global morbidity and mortality in adults, has been reported to be associated with hundreds of genes. A comprehensive understanding of the CHD-related genes and their corresponding interactions is essential to advance the translational research on CHD. Accordingly, we construct this knowledgebase, CHD@ZJU, which records CHD-related information (genes, pathways, drugs and references) collected from different resources and through text-mining method followed by manual confirmation. In current release, CHD@ZJU contains 660 CHD-related genes, 45 common pathways and 1405 drugs accompanied with >8000 supporting references. Almost half of the genes collected in CHD@ZJU were novel to other publicly available CHD databases. Additionally, CHD@ZJU incorporated the protein-protein interactions to investigate the cross-talk within the pathways from a multi-layer network view. These functions offered by CHD@ZJU would allow researchers to dissect the molecular mechanism of CHD in a systematic manner and therefore facilitate the research on CHD-related multi-target therapeutic discovery. Database URL: http://tcm.zju.edu.cn/chd/
authors.affiliation: Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Leihong
authors.initials: L
authors.lastname: Wu
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Jihong
authors.initials: J
authors.lastname: Yang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Fan
authors.forename: Yiyu
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D003327:Coronary Disease / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D057225:Data Mining; D030541:Databases, Genetic; D006801:Humans; D051188:Knowledge Bases; D012106:Research; D057386:Search Engine; D015398:Signal Transduction / Q000235:genetics; D014584:User-Computer Interface