title: Regulatory T cells and immune tolerance in the intestine.
abstract: A fundamental role of the mammalian immune system is to eradicate pathogens while minimizing immunopathology. Instigating and maintaining immunological tolerance within the intestine represents a unique challenge to the mucosal immune system. Regulatory T cells are critical for continued immune tolerance in the intestine through active control of innate and adaptive immune responses. Dynamic adaptation of regulatory T-cell populations to the intestinal tissue microenvironment is key in this process. Here, we discuss specialization of regulatory T-cell responses in the intestine, and how a breakdown in these processes can lead to chronic intestinal inflammation.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Harrison
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Powrie
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology; D041981:Gastrointestinal Tract / Q000166:cytology / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D016753:Interleukin-10 / Q000276:immunology; D007422:Intestines / Q000166:cytology / Q000276:immunology*; D064307:Microbiota / Q000502:physiology; D018448:Models, Immunological; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D016212:Transforming Growth Factor beta; D016753:Interleukin-10