title: IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies.
abstract: TGFBI gene mutations cause corneal stromal dystrophies of autosomal dominant inheritance. The most frequent complication of stromal dystrophies is recurrent corneal erosion with varying degree of accompanying inflammation. IL-1beta, IL-6 and IL-8 are main cytokines involved in corneal erosion healing. This study aimed to investigate the association between IL1B gene -511C/T, IL6 gene -174G/C and IL8 gene -781C/T polymorphisms and risk of recurrent erosion development in patients with hereditary corneal stromal dystrophies. A trend to decrease of IL1B gene -511TT genotype frequency in group with erosion (3.7%) comparing to control (6.7%) was observed. IL6 gene -174C allele carriers frequency in control group (65.9%) was significantly (P < 0.05) lower comparing to patients with erosion (80.5%). Frequency of IL8 -781TT genotype was significantly (P < 0.05) lower in the group with erosion (10.7%) comparing to patients without erosion (30.8%) and control (25%). IL6 gene -174C allele may be considered as genetic marker of corneal erosion risk in patients with hereditary stromal corneal dystrophies, whereas IL8 -781TT genotype is associated with negative recurrent erosion prognosis in such patients.
authors.affiliation: Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv. kucherenko.a.m@gmail.com
authors.forename: A M
authors.initials: AM
authors.lastname: Kucherenko
authors.forename: V M
authors.initials: VM
authors.lastname: Pampukha
authors.forename: G I
authors.initials: GI
authors.lastname: Drozhzhyna
authors.forename: L A
authors.initials: LA
authors.lastname: Livshits
mesh_terms: D016022:Case-Control Studies; D003317:Corneal Dystrophies, Hereditary / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D003319:Corneal Stroma / Q000276:immunology* / Q000293:injuries; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D016209:Interleukin-8 / Q000235:genetics*; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D012008:Recurrence; D053773:Transforming Growth Factor beta1 / Q000235:genetics
chemical_list: C508606:CXCL8 protein, human; C508585:IL1B protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1