title: Hepatitis B infection increases the risk of non-Hodgkin lymphoma: a meta-analysis of observational studies.
abstract: Hepatitis B virus (HBV) infection is a major public health problem and the association between HBV infection and non-Hodgkin lymphoma (NHL) is unclear. The primary aim of our study was to evaluate the association between HBV infection assessed by a positive hepatitis B surface antigen (HBsAg) and the incidence of NHL and subtypes using a meta-analysis of epidemiological studies. The random effects model was used to calculate the outcome. Our search yielded 17 case-control and 5 cohort studies, including over 40,000 NHL cases. HBV infected individuals had an OR of 2.24 (95% CI 1.80-2.78; p ≤ 0.001) of developing NHL. In high HBV prevalent countries, there were increased odds of diffuse large B-cell lymphoma and a trend toward increased odds of developing follicular and T-cell lymphoma. Future research is needed to better understand the biological mechanisms responsible for lymphomagenesis in patients with HBV infection.
authors.affiliation: H. Lee Moffitt Cancer and Research Institute, Division of Hematological Malignancies and the University of South Florida, Tampa, FL, USA. sdalia@gmail.com
authors.forename: Samir
authors.initials: S
authors.lastname: Dalia
authors.forename: Julio
authors.initials: J
authors.lastname: Chavez
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Castillo
authors.forename: Lubomir
authors.initials: L
authors.lastname: Sokol
mesh_terms: D016022:Case-Control Studies; D006509:Hepatitis B / Q000150:complications* / Q000821:virology; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology*; D011379:Prognosis
keywords: Diffuse large b-cell lymphoma; Follicular lymphoma; Hepatitis B; NHL; Non-Hodgkin lymphoma; T-cell lymphoma