title: [Protective effects of carnosine against closed head injury in mice].
abstract: OBJECTIVE
  To investigate the protective effects of carnosine against experimental closed head injury (CHI) in mice.
  
  
  METHODS
  The CHI model was established by free-falling weight-drop. Carnosine (250 mg/kg or 500 mg/kg) was administered intraperitoneally 30 min before brain trauma, then q.d for 7 d; while normal saline was administrated for control group. The neurological defect was evaluated by neurological severity score (NSS) within 7 d; the survival rate and the histological alternations were observed.
  
  
  RESULTS
  Carnosine prevented the body weight loss of mice at dose of 500 mg/kg; significantly increased the survival rate, and reduced the neurological defect and histological damage at dose of 250 and 500 mg/kg.
  
  
  CONCLUSIONS
  Carnosine can attenuate closed head injury in mice.
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Xuying
authors.initials: X
authors.lastname: Pei
authors.forename: Kangxin
authors.initials: K
authors.lastname: Ni
authors.forename: You
authors.initials: Y
authors.lastname: Zhou
authors.forename: Kun
authors.initials: K
authors.lastname: Ying
authors.forename: Xiangnan
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuyun
authors.initials: X
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D002336:Carnosine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D016489:Head Injuries, Closed / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D002336:Carnosine