title: Continuous-flow stereoselective organocatalyzed Diels-Alder reactions in a chiral catalytic "homemade" HPLC column.
abstract: Continuous-flow organocatalyzed Diels-Alder reactions have been performed with excellent enantioselectivity for the first time in a chiral "homemade" HPLC column, packed with silica on which a MacMillan catalyst has been supported by a straightforward immobilization procedure. The versatility of the system was also proven by running with the same column continuous-flow stereoselective reactions with three different substrates, showing that the catalytic reactor may efficiently work in continuo for more than 150 h; the regeneration of the HPLC column was also demonstrated, allowing to further extend the activity of the reactor to more than 300 operating hours.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, I-20133 Milano, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Chiroli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Benaglia
authors.forename: Franco
authors.initials: F
authors.lastname: Cozzi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Puglisi
authors.forename: Rita
authors.initials: R
authors.lastname: Annunziata
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Celentano