title: The total synthesis of hypodematine.
abstract: Hypodematine, isolated from Hypodematium sinense Iwatsuki as an alkaloid with a new skeleton, was synthesized via nine reaction steps, in which the synthesis of 2-aryl-1-benzazocines via Beckmann rearrangement of 5H-benzocyclohepten-5-one oxime mesylate in dry toluene is discussed.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , 100050 , China.
authors.forename: Zhi-Yun
authors.initials: ZY
authors.lastname: Kang
authors.forename: Qing-Jian
authors.initials: QJ
authors.lastname: Zhang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: Pei-Cheng
authors.initials: PC
authors.lastname: Zhang
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D029624:Ferns / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry
chemical_list: D000470:Alkaloids; D008698:Mesylates; D010091:Oximes; C071427:hypodematine