title: MicroRNAs involved in skeletal muscle development and their roles in rhabdomyosarcoma pathogenesis.
abstract: MicroRNAs (miRs) are small non-coding RNAs known to fulfill various functions in tissue development, function, and pathogenesis of various diseases, including cancer. Rhabdomyosarcoma (RMS) represents the most common soft tissue tumor in the pediatric population. miRs have been shown to play important roles in RMS pathogenesis and some of the studies suggest their potential as diagnostic, prognostic, and even therapeutic tools facilitating better management of this disease. This review summarizes current information about the role of miRs in the development of normal skeletal muscle and their deregulation in RMS.
authors.affiliation: Faculty of Medicine, Department of Physiology, Masaryk University, Brno, Czech Republic; Faculty of Medicine, Department of Pathological Physiology, Masaryk University, Brno, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Novák
authors.forename: Jan
authors.initials: J
authors.lastname: Vinklárek
authors.forename: Julie
authors.initials: J
authors.lastname: Bienertová-Vašků
authors.forename: Ondřej
authors.initials: O
authors.lastname: Slabý
mesh_terms: D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D024510:Muscle Development / Q000235:genetics*; D018482:Muscle, Skeletal / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D012208:Rhabdomyosarcoma / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: microRNA; myogenesis; myomirs; rhabdomyosarcoma