title: Adipocytokine levels of colon cancer patients before and after treatment.
abstract: OBJECTIVE
  In the present study, we investigated the associations between pre- and post-treatment levels of adiponectin, ghrelin, resistin, visfatin and leptin levels in malign and benign groups.
  
  
  METHODS
  20 malign colon carcinoma groups and 20 benign groups were included in this study. Serum levels of leptin, adiponectin, resistin, ghrelin, and visfatin were measured by Elisa kits (Milipore Corporation, Billerica, MA, USA).
  
  
  RESULTS
  In the malign group, serum ghrelin (71.90±23.7) levels significantly decreased (p<0.05) when compared to those in the benign (88.00±16.9) group. However, serum resistin (4.92±2.2, 3.39±1.1) levels increased statistically significantly (p<0.05). In the malign group, serum visfatin (0.85±0.6, 0.83±0.5), adiponektin (60.31±23.1, 56.39±25.9) and leptin (3.08±1.4, 3.74±1.3) levels were not statistically significantly different from those in the benign group. In the malign treatment group, serum adiponectin (102.64±50.3, 66.64±27.0) levels were increased significantly (p<0.05); however, serum visfatin (1.17±0.9, 0.68±0.3), ghrelin (85.52±29.5, 82.18±18.0), leptin (5.65±2.8, 3.16±1.1), and resistin (5.96±2.8, 5.65±1.7) levels did not change significantly (p<0.05) compared to those in the respective benign treatment group.
  
  
  CONCLUSIONS
  We showed that adipocytokines were involved in the carcinogenic process. The present results suggest that resistin and ghrelin may be important biomarkers of colon cancer. Furthermore, an in vitro study will also be necessary to evaluate the direct function of these adipocytokines in cancer cells. In addition, it will be appropriate to conduct new studies with a large number of patients at different stages (Tab. 1, Fig. 2, Ref. 24).
authors.affiliation: Celal Bayar University School of Health, Manisa, Turkey. fundakosova@gmail.com
authors.forename: F
authors.initials: F
authors.lastname: Kosova
authors.forename: T
authors.initials: T
authors.lastname: Coskun
authors.forename: Y
authors.initials: Y
authors.lastname: Kaya
authors.forename: E
authors.initials: E
authors.lastname: Kara
authors.forename: Z
authors.initials: Z
authors.lastname: Ari
mesh_terms: D054392:Adipokines / Q000097:blood*; D003110:Colonic Neoplasms / Q000097:blood* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies
chemical_list: D054392:Adipokines