title: Mouse prostate epithelial luminal cells lineage originate in the basal layer where the primitive stem/early progenitor cells reside: implications for identifying prostate cancer stem cells.
abstract: Prostate stem cells are thought to be responsible for generation of all prostate epithelial cells and for tissue maintenance. The lineage relationship between basal and luminal cells in the prostate is not well clarified. We developed a mouse model to trace cell fate and a mouse model with a slowly cycling cell label to provide insight into this question. The results obtained indicate that putative mouse prostate stem cells are likely to reside in the basal layer.
authors.affiliation: Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhou
authors.forename: Lionel
authors.initials: L
authors.lastname: Feigenbaum
authors.forename: Carole
authors.initials: C
authors.lastname: Yee
authors.forename: Hongbin
authors.initials: H
authors.lastname: Song
authors.forename: Clayton
authors.initials: C
authors.lastname: Yates
mesh_terms: D000818:Animals; D002453:Cell Cycle; D019070:Cell Lineage; D004847:Epithelial Cells / Q000378:metabolism* / Q000473:pathology*; D060005:Genotyping Techniques; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006801:Humans; D019426:Integrases / Q000378:metabolism; D053547:Keratin-14 / Q000378:metabolism; D053555:Keratin-5 / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology*; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*
chemical_list: D053547:Keratin-14; D053555:Keratin-5; D049452:Green Fluorescent Proteins; C045073:Cre recombinase; D019426:Integrases