title: Severe systemic reaction from calcium hydroxylapatite vocal fold filler.
abstract: We describe a severe systemic reaction that occurred following injection augmentation with calcium hydroxylapatite vocal fold filler. The reaction occurred within 30 minutes of the procedure and consisted of diffuse itching, hives, edematous face and eyelids, and voice changes indicating glottic edema. It is classified as a grade 3 systemic reaction. Consideration is given to possible etiologies and at risk patients are discussed. We recommend a postprocedure observation time of at least 30 minutes to monitor for such reactions.
authors.affiliation: Department of Otolaryngology, Weill Cornell Medical College, New York, New York, U.S.A.
authors.forename: Justin C
authors.initials: JC
authors.lastname: Cohen
authors.forename: William
authors.initials: W
authors.lastname: Reisacher
authors.forename: Melanie
authors.initials: M
authors.lastname: Malone
authors.forename: Lucian
authors.initials: L
authors.lastname: Sulica
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced* / Q000503:physiopathology; D001672:Biocompatible Materials; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D017886:Durapatite / Q000009:adverse effects* / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000473:pathology / Q000601:surgery; D016629:Esophagectomy / Q000009:adverse effects* / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D007828:Laryngoscopy / Q000379:methods; D008991:Monitoring, Physiologic; D018570:Risk Assessment; D012720:Severity of Illness Index; D014826:Vocal Cord Paralysis / Q000209:etiology / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite
keywords: Calcium hydroxylapatite; anaphylaxis, injection augmentation, laryngoplasty, vocal fold paralysis; systemic reaction; vocal fold filler