title: Evaluation of synovial inflammation in juvenile idiopathic arthritis by power color Doppler and Spectral Doppler ultrasonography.
abstract: OBJECTIVE
  To compare Power Color Doppler and Spectral Doppler ultrasonography indices (Resistive index and color fraction) in cases of Juvenile Idiopathic Arthritis (JIA) with healthy controls and evaluate their correlation with clinical and laboratory parameters.
  
  
  METHODS
  A cross sectional study was done over a period of 16 mo. Thirty patients of JIA and 30 age and sex matched healthy children were enrolled. Swelling and tenderness scores were evaluated and hemoglobin, total leukocyte count, erythrocyte sedimentation rate and C-reactive protein were done. A total of 112 diseased joints and 135 healthy joints were evaluated by USG by the same radiologist, and color fraction and RI were recorded.
  
  
  RESULTS
  Statistically significant higher color fraction and lower RI (Resistive Index) were found in diseased joints as compared to healthy joints. Also the value of color fraction increased significantly with increasing grade of tenderness and RI decreased significantly with increasing grade of swelling.
  
  
  CONCLUSIONS
  Power Color Doppler and Spectral Doppler ultrasonography (USG) indices (RI and color fraction) are significantly different in JIA patients. These might find a place in early diagnosis, monitoring of disease activity and response to therapy in JIA patients.
authors.affiliation: Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Ranjan
authors.forename: Afsana
authors.initials: A
authors.lastname: Jahan
authors.forename: Tribhuvan Pal
authors.initials: TP
authors.lastname: Yadav
authors.forename: Namrita
authors.initials: N
authors.lastname: Sachdev
authors.forename: Vivek
authors.initials: V
authors.lastname: Dewan
authors.forename: Shweta
authors.initials: S
authors.lastname: Singh
mesh_terms: D001171:Arthritis, Juvenile / Q000150:complications*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D013585:Synovitis / Q000000981:diagnostic imaging* / Q000209:etiology*; D018615:Ultrasonography, Doppler, Color