title: Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla.
abstract: Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC50 of 7.6 μM.
authors.affiliation: School of Science, University of Phayao, Maeka, Muang, Phayao 56000, Thailand. sarot.ch@up.ac.th
authors.forename: Sarot
authors.initials: S
authors.lastname: Cheenpracha
authors.forename: Thunwadee
authors.initials: T
authors.lastname: Ritthiwigrom
authors.forename: Surat
authors.initials: S
authors.lastname: Laphookhieo
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031051:Alstonia / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000078183:Oxindoles; D024301:Plant Bark / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D013141:Spiro Compounds; D013785:Thailand
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D026121:Indole Alkaloids; D007211:Indoles; D000078183:Oxindoles; D013141:Spiro Compounds; C582690:alstoniaphylline A; C582689:alstoniaphylline C; C470641:alstonisine