title: [Role of 5-hydroxymethylcytosine and TET proteins in epigenetic regulation of gene expression].
abstract: DNA methylation plays an important role in epigenetic regulation of human gene expression. Mechanism of active demethylation of the human genome have been a matter of discussion for many years. Recently, a novel group of TET protein family enzymatically converting 5-methylcytosine into 5-hydroxymethylcytosine was discovered, playing a role in active DNA demethylation pathway. Results obtained in subsequent studies pointed that 5-hydroxymethylcytosine was not only an intermediate in that pathway, but might also modify epigenetic profile of the human genome.
authors.affiliation: Katedra Genetyki Molekularnej, Wydział Biologii i Ochrony Srodowiska, Uniwersytet Łódzki, Łódź, Poland. sglowa@biol.uni.lodz.pl
authors.forename: Sylwester
authors.initials: S
authors.lastname: Głowacki
authors.forename: Janusz
authors.initials: J
authors.lastname: Błasiak
mesh_terms: D044503:5-Methylcytosine / Q000031:analogs & derivatives; D000818:Animals; D003596:Cytosine / Q000031:analogs & derivatives* / Q000378:metabolism; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000378:metabolism*; D044127:Epigenesis, Genetic; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D006899:Mixed Function Oxygenases; D009369:Neoplasms / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C011865:5-hydroxymethylcytosine; D044503:5-Methylcytosine; D003596:Cytosine; D006899:Mixed Function Oxygenases; C462539:TET1 protein, human