title: Antimicrobial prophylaxis to prevent perioperative infection in urological surgery: a multicenter study.
abstract: We prospectively investigated the rates of incidence of surgical site infection (SSI), urinary tract infection (UTI), and remote infection (RI) in 4,677 patients who underwent urological surgery from January to December 2010, including 2,507 endourological cases, 1,276 clean cases, 807 clean-contaminated cases, and 87 contaminated cases involving bowel segments. A single dose of antimicrobial prophylaxis (AMP) was administered in the endourological, clean, and clean-contaminated surgery cases, except for patients who underwent transurethral resection of the prostate (TURP) or percutaneous nephrolithotripsy (PNL). AMP was administered within 72 h in TURP and PNL, and AMP was administered within 48 h in contaminated surgery cases. In cases of endourological surgery, UTI was observed in 4% and RI in 0%, and SSI, UTI, and RI were seen in 1%, 1%, and 1%, respectively, of clean surgery cases, in 3%, 3%, and 2%, respectively, of clean-contaminated surgery cases, and in 17%, 30%, and 10%, respectively, of contaminated surgery cases. In multivariate analysis of the risk factors for infection, operative time was a significant risk factor for UTI in endourological surgery, and American Society of Anesthesiologists score and operative time were significant risk factors for RI in clean surgery. No significant risk factor was found in analyses of clean-contaminated and contaminated surgery cases. A single-dose AMP regimen was shown to be effective and feasible for prevention of perioperative infection in urological surgery.
authors.affiliation: Department of Urology, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo, 663-8501, Japan, ytogo@hyo-med.ac.jp.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Togo
authors.forename: Shiro
authors.initials: S
authors.lastname: Tanaka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kanematsu
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Miyazato
authors.forename: Hideo
authors.initials: H
authors.lastname: Saito
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Arai
authors.forename: Akio
authors.initials: A
authors.lastname: Hoshi
authors.forename: Toshiro
authors.initials: T
authors.lastname: Terachi
authors.forename: Katsuya
authors.initials: K
authors.lastname: Fukui
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsuda
authors.forename: Motoki
authors.initials: M
authors.lastname: Yamashita
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kakehi
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tsuchihashi
authors.forename: Miharu
authors.initials: M
authors.lastname: Sasaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishitoya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Onishi
authors.forename: Akira
authors.initials: A
authors.lastname: Takahashi
authors.forename: Keiji
authors.initials: K
authors.lastname: Ogura
authors.forename: Mutsuki
authors.initials: M
authors.lastname: Mishina
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okuno
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Oida
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Horii
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hamada
authors.forename: Kosuke
authors.initials: K
authors.lastname: Okasyo
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okumura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwamura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nishimura
authors.forename: Yumi
authors.initials: Y
authors.lastname: Manabe
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hashimura
authors.forename: Mikito
authors.initials: M
authors.lastname: Horikoshi
authors.forename: Takao
authors.initials: T
authors.lastname: Mishima
authors.forename: Takuya
authors.initials: T
authors.lastname: Okada
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Mutsushi
authors.initials: M
authors.lastname: Kawakita
authors.forename: Sojun
authors.initials: S
authors.lastname: Kanamaru
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ito
authors.forename: Dai
authors.initials: D
authors.lastname: Aoki
authors.forename: Risaku
authors.initials: R
authors.lastname: Kawaguchi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yamada
authors.forename: Koji
authors.initials: K
authors.lastname: Kokura
authors.forename: Jun
authors.initials: J
authors.lastname: Nagai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kondoh
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kajio
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000517:prevention & control*; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000517:prevention & control*; D013520:Urologic Surgical Procedures / Q000009:adverse effects / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents