title: Blood utilization in neonates and infants undergoing cardiac surgery requiring cardiopulmonary bypass.
abstract: Neonates and infants undergoing cardiac surgery with cardiopulmonary bypass are exposed to multiple blood products from different donors. The volume of the bypass circuit is often as large as the patient's total blood volume and asanguineous bypass primes are unusual. As a result, blood products are required for the cardiopulmonary bypass prime and are often used to treat the postbypass dilutional coagulopathy. We review clot formation and strength, cardiopulmonary bypass prime considerations, assessment of postbypass coagulopathy, component therapy use, ultrafiltration techniques, and use of antifibrinolytic medications. A combined approach including techniques to minimize the prime volume, utilization of ultrafiltration, administration of antifibrinolytics during surgery, and the proper treatment of the dilutional coagulopathy can limit the transfusion requirements.
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Wesley
authors.forename: Koichi
authors.initials: K
authors.lastname: Yuki
authors.forename: Dima G
authors.initials: DG
authors.lastname: Daaboul
authors.forename: James A
authors.initials: JA
authors.lastname: Dinardo
keywords: CPB; anesthesia (includes agents; blood; blood conservation; blood transfusion; cardiopulmonary bypass (CPB); care and research); coagulation/anticoagulation; components; configurations; congenital heart disease (CHD); congenital heart surgery; fibrin; infant; pharmacology