title: [Expression and clinical significance of secretory leucocyte protease inhibitor in colon carcinoma].
abstract: OBJECTIVE
  To investigate the expression of secretory leucocyte protease inhibitor (SLPI) in colon cancer and their clinical significance.
  
  
  METHODS
  Immunohistochemistry was performed to detect the SLPI expression in colon cancer tissue microarray. The expression of SLPI was scored by two pathologists and was analyzed using Χ(2) test to explore its influence on the pathologic characteristics of colon carcinoma.
  
  
  RESULTS
  SLPI was up-regulated in colon cancer tissue compared to normal mucosa. Overexpression of SLPI protein was correlated with differentiation grade (low differentiation: 42.1% vs 57.9%; moderate/well differentiation: 2.3% vs 97.7%, TNM stages(III-IV:29.4% vs 70.6%;I-II:3.1% vs 96.9%), lymph node metastasis (28.6% vs 71.4%) and distant metastasis (84.6% vs 15.4%), but not with patient age or sex.
  
  
  CONCLUSIONS
  SLPI overexpression correlates with aggressive pathologic characteristics of colon cancer and it may server as prognostic factor of colon cancer patients. Further research will be carried out to verify whether SLPI can become a new target for colon cancer treatment.
authors.affiliation: Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. gjb972@sohu.com
authors.forename: Jiubing
authors.initials: J
authors.lastname: Guo
authors.forename: Guoxin
authors.initials: G
authors.lastname: Li
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhuang
authors.forename: Chenghong
authors.initials: C
authors.lastname: Ji
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Guoquan
authors.initials: G
authors.lastname: Tao
authors.forename: Hanzhang
authors.initials: H
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D046209:Electrophoresis, Microchip; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D053481:Secretory Leukocyte Peptidase Inhibitor / Q000378:metabolism*
chemical_list: D053481:Secretory Leukocyte Peptidase Inhibitor