title: Evaluation of acute/late toxicity and local recurrence in T1-T2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT).
abstract: BACKGROUND
  The aim of the study was to evaluate the efficacy, as well as the acute and late toxicity of an accelerated hypofractionated 3DCRT schedule as radical treatment in patients with organ confined glottic cancer cT1-2N0.
  
  
  METHODS
  Between June of 2004 and September 2010, 47 retrospectively selected patients (29 males, 18 females) diagnosed with organ confined T1 or T2 glottic cancer, were treated with external 3DCRT in an accelerated hypofractionation schedule. The median age was 70 years. A dose of 64.4 Gy in 28 daily fractions was prescribed. The primary study endpoints were to assess the acute and late effects of radiation toxicity, according to the EORTC/ RTOG scale, as well as the therapeutic impact of this schedule in terms of local recurrence.
  
  
  RESULTS
  The median follow up was 36 months. At the end of radiotherapy, grade I, II and III acute toxicity was observed in 34, 9 and4 patients, respectively. Late grade I and II toxicity was observed in 25 and in 8 patients respectively. Only two local recurrences were observed, 15 and 24 months post 3DCRT respectively.
  
  
  CONCLUSIONS
  Our radiotherapy schedule achieves a high locoregional control rate with the advantage of voice preservation. The proposed hypofractionated schedule can be recommended as a standard radiotherapy treatment, since these results are comparable with those of conventional fractionation schedules.
authors.affiliation: 2 Department of Radiology, Radiotherapy Unit, Attikon University Hospital, Medical School, Athens, Greece.
authors.forename: Vassilis E
authors.initials: VE
authors.lastname: Kouloulias
authors.forename: Anna
authors.initials: A
authors.lastname: Zygogianni
authors.forename: Eftychia
authors.initials: E
authors.lastname: Mosa
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Platoni
authors.forename: John
authors.initials: J
authors.lastname: Georgakopoulos
authors.forename: Christos
authors.initials: C
authors.lastname: Antypas
authors.forename: Ivelina
authors.initials: I
authors.lastname: Beli
authors.forename: Maria
authors.initials: M
authors.lastname: Tolia
authors.forename: Paulos
authors.initials: P
authors.lastname: Maragoudakis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Giotakis
authors.forename: Zisis
authors.initials: Z
authors.lastname: Papas
authors.forename: Amanda
authors.initials: A
authors.lastname: Psyrri
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kelekis
authors.forename: John
authors.initials: J
authors.lastname: Kouvaris
keywords: accelerated hypofractionated radiotherapy; early glottic cancer; local recurrence; toxicity