title: Adjuvant treatment in resected non-small cell lung cancer: current and future issues.
abstract: The cornerstone of treatment for early-stage non-small cell lung cancer (NSCLC) has been surgical resection. In the last five years two phase III trials have provided evidence of adjuvant platinum-based chemotherapy for completely resected stage II-IIIA patients. We review the evidence supporting adjuvant therapy in early-stage NSCLC; we discuss new issues surrounding adjuvant therapy such as treatment in the elderly-unfit population, treatment toxicity and its influence on outcomes, the importance of histology and gender in adjuvant treatment; and we discuss the future landscape of early-stage NSCLC research, namely, therapeutic strategies exploiting pharmacogenomic and gene-expression profiling, in an attempt to customize the treatment.
authors.affiliation: Medical Oncology Department, Hospital de Mataró, Carretera de la Cirera, s/n, 08304 Mataró, Barcelona, Spain. Electronic address: jremon@csdm.cat.
authors.forename: Jordi
authors.initials: J
authors.lastname: Remon
authors.forename: Pilar
authors.initials: P
authors.lastname: Lianes
authors.forename: Susana
authors.initials: S
authors.lastname: Martínez
authors.forename: Montserrat
authors.initials: M
authors.lastname: Velasco
authors.forename: Rosa
authors.initials: R
authors.lastname: Querol
authors.forename: Montserrat
authors.initials: M
authors.lastname: Zanui
mesh_terms: D000367:Age Factors; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D055118:Medication Adherence; D058990:Molecular Targeted Therapy; D009367:Neoplasm Staging; D057285:Precision Medicine; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012737:Sex Factors; D012907:Smoking; D016896:Treatment Outcome
keywords: Adjuvant chemotherapy; Lung cancer; Stage IB–IIIA