title: Delayed recovery from ertapenem induced encephalopathy: case-report and a possible mechanism.
abstract: METHODS
  The objective of this case report is to report a patient with moderate renal impairment who developed ertapenem-induced encephalopathy with delayed recovery of up to 2 weeks despite receiving and appropriately adjusted dosage of ertapenem. The patient was managed conservatively with full recovery. Carbapenem related neurotoxicity most commonly manifests as seizure with an estimated incidence of 3 %. There are increasing reports of encephalopathy being related to ertapenem and most commonly subsides within days and extended recovery of up to 2 weeks have only been reported in patients with end-stage renal failure.
  
  
  CONCLUSIONS
  Prolonged ertapenem induced encephalopathy can occur in patients with moderate renal impairment. These patients can be managed conservatively and they should make a complete recovery.
authors.affiliation: Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China. elphashea@gmail.com
authors.forename: Yat-fung
authors.initials: YF
authors.lastname: Shea
authors.forename: Ming-yee Maggie
authors.initials: MY
authors.lastname: Mok
authors.forename: Ka-chun
authors.initials: KC
authors.lastname: Cheng
authors.forename: Fong-kwong Sonny
authors.initials: FK
authors.lastname: Hon
authors.forename: Leung-wing
authors.initials: LW
authors.lastname: Chu
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D000077727:Ertapenem; D005260:Female; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D051437:Renal Insufficiency / Q000150:complications / Q000503:physiopathology; D012720:Severity of Illness Index; D013997:Time Factors; D047090:beta-Lactams / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D000077727:Ertapenem