title: Clinicians' attitudes toward the use of long-acting injectable antipsychotics.
abstract: Depot formulations are not widely used in everyday practice. This study aimed to assess psychiatrists' attitudes toward the use of long-acting injectable (LAI) antipsychotics in schizophrenia. We interviewed 113 French psychiatrists about the factors that influenced their prescription of LAI antipsychotics. Multidimensional and cluster analyses were used to detect correlations. The most important factor against the use of LAI antipsychotics is a sufficient estimated compliance with the oral formulation. For first-generation LAI, the main factor is the risk for extrapyramidal symptoms; and for second-generation LAI, it is the unavailability of the equivalent oral formulation. Four factors incite the psychiatrists to prescribe LAI. Two different clusters of patients can also be identified. Most factors influencing the clinicians' attitudes toward the use of LAI antipsychotics are shared in many countries. Conversely, some attitudes related to organizational aspects, particularly the relevance of health care costs, may vary from one country to another.
authors.affiliation: Department of Psychiatry B, University of Auvergne, Clermont-Ferrand, France. lsamalin@chu-clermontferrand.fr
authors.forename: Ludovic
authors.initials: L
authors.lastname: Samalin
authors.forename: Thomas
authors.initials: T
authors.lastname: Charpeaud
authors.forename: Olivier
authors.initials: O
authors.lastname: Blanc
authors.forename: Stephan
authors.initials: S
authors.lastname: Heres
authors.forename: Pierre-Michel
authors.initials: PM
authors.lastname: Llorca
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D005260:Female; D005602:France; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010818:Practice Patterns, Physicians'; D011570:Psychiatry / Q000379:methods; D012559:Schizophrenia / Q000188:drug therapy*; D011795:Surveys and Questionnaires
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations