title: Coadministration of telaprevir and transcatheter arterial chemoembolization in hepatitis C virus-associated hepatocellular carcinoma.
abstract: The use of direct-acting antiviral agents (e.g., telaprevir, boceprevir) has improved response rates in patients with hepatitis C virus (HCV) genotype 1 infections. Substantial number of drug-drug interactions are anticipated with the use of telaprevir, a cytochrome P450 3A and P-glycoprotein substrate and inhibitor. Herein we describe a patient with HCV-associated hepatocellular carcinoma treated simultaneously with a telaprevir-containing regimen and localized chemotherapy (transcatheter arterial chemoembolization) with doxorubicin. No clinically relevant interactions or adverse events developed while on antiviral therapy.
authors.affiliation: Harrys A Torres, Parag Mahale, Departments of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
authors.forename: Harrys A
authors.initials: HA
authors.lastname: Torres
authors.forename: Parag
authors.initials: P
authors.lastname: Mahale
authors.forename: Ethan D
authors.initials: ED
authors.lastname: Miller
authors.forename: Thein H
authors.initials: TH
authors.lastname: Oo
authors.forename: Catherine
authors.initials: C
authors.lastname: Frenette
authors.forename: Ahmed O
authors.initials: AO
authors.lastname: Kaseb
keywords: Cancer; Hepatitis C virus; Hepatocellular carcinoma; Interactions; Telaprevir; Transcatheter arterial chemoembolization