title: Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study.
abstract: OBJECTIVE
  To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.
  
  
  METHODS
  The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.
  
  
  RESULTS
  The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.
  
  
  CONCLUSIONS
  This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.
authors.affiliation: Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands. Electronic address: w.krudop@vumc.nl.
authors.forename: Welmoed A
authors.initials: WA
authors.lastname: Krudop
authors.affiliation: Department of Old Age Psychiatry, GGZInGeest, Amsterdam, the Netherlands.
authors.forename: Cora J
authors.initials: CJ
authors.lastname: Kerssens
authors.affiliation: Department of Old Age Psychiatry, GGZInGeest, Amsterdam, the Netherlands.
authors.forename: Annemieke
authors.initials: A
authors.lastname: Dols
authors.affiliation: Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands.
authors.forename: Niels D
authors.initials: ND
authors.lastname: Prins
authors.affiliation: Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands.
authors.forename: Christiane
authors.initials: C
authors.lastname: Möller
authors.affiliation: Department of Old Age Psychiatry, GGZInGeest, Amsterdam, the Netherlands.
authors.forename: Sigfried
authors.initials: S
authors.lastname: Schouws
authors.affiliation: Department of Radiology, VU University Medical Centre, Amsterdam, the Netherlands.
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.affiliation: Department of Nuclear Medicine & PET Research, VU University Medical Centre, Amsterdam, the Netherlands.
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
authors.affiliation: Neurological Laboratory, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, the Netherlands.
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: Teunissen
authors.affiliation: Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands.
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
authors.affiliation: Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.affiliation: Department of Old Age Psychiatry, GGZInGeest, Amsterdam, the Netherlands.
authors.forename: Max L
authors.initials: ML
authors.lastname: Stek
authors.affiliation: Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands.
authors.forename: Yolande A L
authors.initials: YA
authors.lastname: Pijnenburg
mesh_terms: D017668:Age of Onset; D000368:Aged; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002985:Clinical Protocols; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D057180:Frontotemporal Dementia / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016875:tau Proteins; D019788:Fluorodeoxyglucose F18
keywords: behavioral disorders; bvFTD; early diagnosis; psychiatry