title: [Status of the water-soluble component of the antioxidant defense system in the conditions of 520-day isolation].
abstract: In the 520-d chamber experiment within the international project Mars-500 blood samples of 6 male test-subjects of 28 to 39 years of age were analyzed for water-soluble antioxidants: total bilirubin and uric acid; in addition, total antioxidant capacity of blood plasma was determined. Maximal values of these parameters were associated with the most stressful periods of the experiment, i.e. adaptation to the life in isolation and confinement, simulation of the egress onto Martian surface, and change of the diet. On attainment of the homeostatic equilibrium the parameters stabilized on levels slightly lower relative to baseline (pre-isolation) values. Therefore, dynamics of the water-soluble antioxidants reflected adequately the homeostatic reactions to and compensation by organism of the effects of the 520-day life in isolation and confinement.
authors.forename: B V
authors.initials: BV
authors.lastname: Morukov
authors.forename: I N
authors.initials: IN
authors.lastname: Popov
authors.forename: G
authors.initials: G
authors.lastname: Levin
authors.forename: A A
authors.initials: AA
authors.lastname: Markin
authors.forename: O A
authors.initials: OA
authors.lastname: Zhuravleva
authors.forename: D S
authors.initials: DS
authors.lastname: Kuzichkin
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood; D018504:Ecological Systems, Closed; D005526:Food, Formulated; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D018535:Mars; D012995:Solubility; D013026:Space Flight; D014527:Uric Acid / Q000097:blood; D014867:Water / Q000378:metabolism
chemical_list: D000975:Antioxidants; D014867:Water; D014527:Uric Acid; D001663:Bilirubin