title: Prion-like propagation of protein aggregation and related therapeutic strategies.
abstract: Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.
authors.affiliation: Department of Neurology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Kaufman
authors.forename: Marc I
authors.initials: MI
authors.lastname: Diamond
mesh_terms: D016229:Amyloid beta-Peptides; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D009474:Neurons / Q000378:metabolism; D011328:Prions / Q000378:metabolism*; D011487:Protein Conformation; D051844:alpha-Synuclein
chemical_list: D016229:Amyloid beta-Peptides; D011328:Prions; D051844:alpha-Synuclein