title: [Evaluation of cyto- and genotoxic action of ferronanomagnetic and constant magnetic field in in vivo system].
abstract: Cyto- and genotoxic effects of nanoparticles on the basis of FM, CMF or their combination have been studied in AKE cells, BM cells of erythroid line, and peripheral blood lymphocytes with the use of MN test and "DNA-comet" assay. It has been shown that expression of mentioned effects is related to FM concentration and duration of tested agent action. It has been also demonstrated that action of CMF alone in the studied cells did not cause any changes in cell architectonics or affect MN counts which are associated with DNA damage. When FM and CMF were used in combination there has been observed the phenomenon of induction of CMF action with FM nanoparticles. The obtained results allow recommend MN test and "DNA-comet" assay as the markers of genome stability in the tests of genotoxic effects of nanomaterials for development of vector nanosystems.
authors.forename: V F
authors.initials: VF
authors.lastname: Chekhun
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Lozovs'ka
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Luk'ianova
authors.forename: D V
authors.initials: DV
authors.lastname: Demash
authors.forename: I M
authors.initials: IM
authors.lastname: Todor
authors.forename: L A
authors.initials: LA
authors.lastname: Nalieskina
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D020552:Comet Assay; D004305:Dose-Response Relationship, Drug; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000648:ultrastructure; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D060526:Magnetic Fields / Q000009:adverse effects*; D058185:Magnetite Nanoparticles / Q000633:toxicity*; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D013997:Time Factors
chemical_list: D058185:Magnetite Nanoparticles; D009153:Mutagens