title: One-step signal amplified lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A (BPA) in aqueous samples.
abstract: A one-step signal amplified lateral flow strip (LFS) biosensor has been developed for ultrasensitive and on-site visual detection of bisphenol A (BPA). This signal amplified LFS was based on the dual labeling using different-sized gold nanoparticles (Duo-LFS). This Duo-LFS could achieve BPA detection with 0.5 ng/mL as the visual sensitivity by naked eye observation and with 0.076 ng/mL as the limit of detection (LOD) for semi-quantitative detection by software analysis, which is at least 10-fold improvement of the sensitivity of traditional LFS based methods. This one-step signal amplified lateral flow strip biosensor and related signal enhancement method could be adopted as a potential generous technique for all LFS-based detection methods.
authors.affiliation: School of Biotechnology and Food Engineering, Anhui Provincial Key Lab of Advanced Functional Materials & Devices, Hefei University of Technology, Hefei 230009, PR China.
authors.forename: Zhanlong
authors.initials: Z
authors.lastname: Mei
authors.forename: Wei
authors.initials: W
authors.lastname: Qu
authors.forename: Yi
authors.initials: Y
authors.lastname: Deng
authors.forename: Huaqin
authors.initials: H
authors.lastname: Chu
authors.forename: Jinxuan
authors.initials: J
authors.lastname: Cao
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.forename: Hani Said
authors.initials: HS
authors.lastname: El-Nezamic
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D001559:Benzhydryl Compounds / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D006046:Gold / Q000737:chemistry; D064088:Hazard Analysis and Critical Control Points; D057230:Limit of Detection; D053758:Nanoparticles / Q000737:chemistry; D010636:Phenols / Q000032:analysis*; D011934:Reagent Strips / Q000032:analysis*; D014867:Water / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D006046:Gold; D010636:Phenols; D011934:Reagent Strips; D014867:Water; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: BPA detection; Food safety; Lateral flow strip; Sensitivity amplification