title: Anthocyanin-Rich Juice Lowers Serum Cholesterol, Leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats.
abstract: Obesity and obesity-associated diseases e.g. cardiovascular diseases and type 2 diabetes are spread worldwide. Anthocyanins are supposed to have health-promoting properties, although convincing evidence is lacking. The aim of the present study was to investigate the effect of anthocyanins on several risk factors for obesity-associated diseases. Therefore, Fischer rats were fed anthocyanin-rich grape-bilberry juice or an anthocyanin-depleted control juice for 10 weeks. Intervention with anthocyanin-rich grape-bilberry juice reduced serum cholesterol and tended to decrease serum triglycerides. No effects were seen for serum non-esterified fatty acids, glucose, and insulin. Anthocyanin-rich grape-bilberry juice intervention reduced serum leptin and resistin, but showed no influence on serum adiponectin and secretion of adipokines from mesenteric adipose tissue. Furthermore, anthocyanin-rich grape-bilberry juice increased the proportion of polyunsaturated fatty acids and decreased the amount of saturated fatty acids in plasma. These results indicate that anthocyanins possess a preventive potential for obesity-associated diseases.
authors.affiliation: Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Karlsruhe, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Graf
authors.forename: Stephanie
authors.initials: S
authors.lastname: Seifert
authors.forename: Anke
authors.initials: A
authors.lastname: Jaudszus
authors.forename: Achim
authors.initials: A
authors.lastname: Bub
authors.forename: Bernhard
authors.initials: B
authors.lastname: Watzl
mesh_terms: D054392:Adipokines / Q000097:blood; D000818:Animals; D000872:Anthocyanins / Q000032:analysis*; D001628:Beverages; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005247:Feeding Behavior; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D052243:Resistin / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D054392:Adipokines; D000872:Anthocyanins; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D020738:Leptin; D052243:Resistin; D014280:Triglycerides; D002784:Cholesterol