title: Keeping blood vessels out of sight.
abstract: Researchers have identified a soluble receptor that prevents blood vessels forming in the outer retina-a process that can lead to blindness-by sequestering vascular endothelial growth factor.
authors.affiliation: is at the UCL Institute of Ophthalmology , London , United Kingdom d.sim@ucl.ac.uk.
authors.forename: Dawn
authors.initials: D
authors.lastname: Sim
authors.forename: Marcus
authors.initials: M
authors.lastname: Fruttiger
mesh_terms: D000818:Animals; D020256:Choroidal Neovascularization / Q000378:metabolism*; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000378:metabolism*; D008297:Male; D020419:Photoreceptor Cells, Vertebrate / Q000378:metabolism*; D015861:Retinal Neovascularization / Q000378:metabolism*; D055213:Retinal Pigment Epithelium / Q000378:metabolism*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism*; D014785:Vision, Ocular
chemical_list: C501162:FLT1 protein, human; C501163:Flt1 protein, mouse; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: Human; Mouse; metabolism; ophthalmology; retinal vasculature; soluble VEGF receptor-1; transgenic model; vascular demarcation