title: 99mTc-HYNIC-TOC (99mTc-hydrazinonicotinyl-Tyr3-octreotide) scintigraphy identifying two separate causative tumors in a patient with tumor-induced osteomalacia (TIO).
abstract: Tumors that cause osteomalacia are generally benign fibroblast growth factor-23 producing mesenchymal tumors which can be detected by octreoscan. A 45-year-old man underwent (99m)Tc-HYNIC-TOC scan to detect a possible culprit causing osteomalacia. The images showed abnormal activity in the left humerus and in the right foot. The lesion of the right foot was confirmed pathologically as phosphaturic mesenchymal tumor. After surgical removal of the tumor in the right foot, the patient's symptoms were promptly improved. However, the improvement was transient due to the unresected tumor in the left humerus.
authors.affiliation: Department of Nuclear Medicine, Beijing Union Medical College Hospital, Beijing, China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Jing
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Dingrong
authors.initials: D
authors.lastname: Zhong
authors.forename: Hongming
authors.initials: H
authors.lastname: Zhuang
mesh_terms: D001859:Bone Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging*; D005528:Foot / Q000000981:diagnostic imaging; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000031:analogs & derivatives*; D015609:Organotechnetium Compounds; D010018:Osteomalacia / Q000209:etiology*; D011877:Radionuclide Imaging
chemical_list: D015609:Organotechnetium Compounds; C410263:technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; D015282:Octreotide