title: Diagnostic value of anti-gp210 antibodies in primary biliary cirrhosis: a case-based review.
abstract: Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterised by chronic cholestasis usually associated with antimitochondrial antibodies. Moreover, several types of antinuclear antibodies have been associated with primary biliary cirrhosis. We describe an 83-year-old man, in whom the exploration of a chronic cholestasis led to the diagnosis of primary biliary cirrhosis despite negative antimitochondrial antibodies, regarding the presence of anti-gp210 antibodies. Found in 25% of patients, these antinuclear antibodies must be sought before a strong suspicion of primary biliary cirrhosis with antimitochondrial antibodies negative, as they are highly specific of the disease. They are generally associated with a more aggressive form of PBC.
authors.affiliation: Department of Médecine Interne, Hospices Civils de Lyon, Pierre Bénite, France. florent.valour@chu-lyon.fr
authors.forename: Florent
authors.initials: F
authors.lastname: Valour
authors.forename: Stéphane
authors.initials: S
authors.lastname: Durupt
authors.forename: Safia
authors.initials: S
authors.lastname: Khenifer
authors.forename: Isabelle
authors.initials: I
authors.lastname: Durieu
mesh_terms: D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000276:immunology*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D028861:Nuclear Pore Complex Proteins / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; C063865:NUP210 protein, human; D028861:Nuclear Pore Complex Proteins