title: Use of a strontium-enriched calcium phosphate cement in accelerating the healing of soft-tissue tendon graft within the bone tunnel in a rabbit model of anterior cruciate ligament reconstruction.
abstract: We investigated whether strontium-enriched calcium phosphate cement (Sr-CPC)-treated soft-tissue tendon graft results in accelerated healing within the bone tunnel in reconstruction of the anterior cruciate ligament (ACL). A total of 30 single-bundle ACL reconstructions using tendo Achillis allograft were performed in 15 rabbits. The graft on the tested limb was treated with Sr-CPC, whereas that on the contralateral limb was untreated and served as a control. At timepoints three, six, nine, 12 and 24 weeks after surgery, three animals were killed for histological examination. At six weeks, the graft-bone interface in the control group was filled in with fibrovascular tissue. However, the gap in the Sr-CPC group had already been completely filled in with new bone, and there was evidence of the early formation of Sharpey fibres. At 24 weeks, remodelling into a normal ACL-bone-like insertion was found in the Sr-CPC group. Coating of Sr-CPC on soft tissue tendon allograft leads to accelerated graft healing within the bone tunnel in a rabbit model of ACL reconstruction using Achilles tendon allograft.
authors.affiliation: University of Hong Kong, Department of Orthopaedics & Traumatology, 21 Sassoon Road, Pokfulam, Hong Kong.
authors.forename: G M
authors.initials: GM
authors.lastname: Kuang
authors.forename: W P
authors.initials: WP
authors.lastname: Yau
authors.forename: W W
authors.initials: WW
authors.lastname: Lu
authors.forename: K Y
authors.initials: KY
authors.lastname: Chiu
mesh_terms: D000125:Achilles Tendon / Q000637:transplantation*; D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D059549:Anterior Cruciate Ligament Reconstruction / Q000379:methods*; D001843:Bone Cements / Q000627:therapeutic use*; D001842:Bone and Bones / Q000601:surgery*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D011817:Rabbits; D019651:Plastic Surgery Procedures / Q000379:methods*; D013324:Strontium / Q000627:therapeutic use*; D013710:Tendons / Q000601:surgery* / Q000637:transplantation; D014945:Wound Healing
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate; D013324:Strontium
keywords: Anterior cruciate ligament (ACL); Calcium phosphate cement (CPC); Strontium; Tendon-bone healing