title: Oestrogen receptor alpha gene polymorphisms relationship with semen variables in infertile men.
abstract: This study aimed to assess the association of oestrogen receptor alpha (ER-α) gene polymorphisms and semen variables in infertile oligoasthenoteratozoospermic (OAT) men. In all, 141 men were grouped into fertile men (n = 60) and infertile OAT men (n = 81). They were subjected to assessment of semen analysis, acrosin activity, serum reproductive hormones and genotyping of ER-α gene. Frequencies of p and x alleles in ER-α gene PvuII and XbaI polymorphisms were more prevalent among fertile men compared with infertile OAT men. Presence of P and X alleles was associated with increased incidence of male infertility for genotypes PP, XX compared with genotypes pp and xx (OR = 2.8; 95% CI: 2.36-6.97; P = 0.001 and OR = 4.1, 95% CI: 1.49-11.39; P = 0.001, respectively). The mean of semen variables and sperm acrosin activity were significantly higher in cases associated with pp than PP and in xx than XX genotypes of ER-α gene. Mean levels of all serum reproductive hormones demonstrated nonsignificant differences in different ER-α genotypes except oestrogen that was elevated in PP and XX ER-α gene genotypes. It is concluded that as oestrogen is concerned in male gamete maturation, ER-α gene polymorphisms might play a role in the pathophysiology of male infertility.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: Zalata
authors.forename: H A
authors.initials: HA
authors.lastname: Abdalla
authors.forename: Y
authors.initials: Y
authors.lastname: El-Bayoumy
authors.forename: T
authors.initials: T
authors.lastname: Mostafa
mesh_terms: D000176:Acrosin / Q000378:metabolism; D053627:Asthenozoospermia / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005787:Gene Frequency; D006728:Hormones / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009845:Oligospermia / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D012150:Polymorphism, Restriction Fragment Length; D055101:Semen Analysis; D013094:Spermatozoa / Q000201:enzymology
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D006728:Hormones; D000176:Acrosin
keywords: Hormones; male infertility; oestrogen; polymorphism; semen