title: Synthesis and radical scavenging activities of resveratrol analogs.
abstract: Highly substituted polyhydroxylated (E)-stilbenes were synthesized by Mizoroki-Heck reactions and tested for their ability to act as radical scavenger. One of the 56 stilbenes included in this study and investigated in DPPH assays gave an SC50 value of 11.0 μM, hence exhibiting an about 9.3 times higher activity than resveratrol. As shown in a photometric SRB assay using mouse NiH 3T3 fibroblasts, this compound is not cytotoxic up to concentrations of <30 μM.
authors.affiliation: Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Halle (Saale), Germany. rene.csuk@chemie.uni-halle.de
authors.forename: René
authors.initials: R
authors.lastname: Csuk
authors.forename: Sabrina
authors.initials: S
authors.lastname: Albert
authors.forename: Bianka
authors.initials: B
authors.lastname: Siewert
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D010851:Picrates / Q000737:chemistry; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D013267:Stilbenes; C004931:1,1-diphenyl-2-picrylhydrazyl; D000077185:Resveratrol
keywords: French paradox; Radical scavengers; Resveratrol analogs