title: E-Factor minimized hydrophosphonylation of aldehydes catalyzed by polystyryl-BEMP under solvent-free conditions.
abstract: An efficient protocol for the hydrophosphonylation of aromatic and aliphatic aldehydes catalyzed by PS-BEMP under solvent-free conditions (SolFC) has been reported. Addition reactions were performed by using equimolar amounts of reagents and the resulting α-hydroxyphosphonates were isolated with simple workup procedures. A large scale protocol for the preparation of a representative α-hydroxyphosphonate 3a has been also set up using a flow reactor.
authors.affiliation: Laboratory of Green Synthetic Organic Chemistry, CEMIN - Dipartimento di Chimica, Università di Perugia Via Elce di Sotto, 8, Perugia, Italia.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Angelini
authors.forename: Simona
authors.initials: S
authors.lastname: Bonollo
authors.forename: Daniela
authors.initials: D
authors.lastname: Lanari
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Pizzo
authors.forename: Luigi
authors.initials: L
authors.lastname: Vaccaro
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000145:classification*; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000145:classification*; D010766:Phosphorylation; D011137:Polystyrenes / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D006573:Heterocyclic Compounds, 1-Ring; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D011137:Polystyrenes; C116638:BEMP phosphazene