title: [Mitokorrektine stimulates angiogenesis in vitro].
abstract: The effect of mitokorrectine (complex native oligopeptides isolated from neonatal pig brain) on endothelial cells in culture was investigated. It was revealed that the drug concentration-dependently induces angiogenesis in vitro. Mitogen effect of Mitokorrectine was shown by MTT-test and routine cell count in concentration diapason (0.1-1 mg/ml) which means an increased number of cells by 25 +/- 5% and cell subpopulation of proliferative pool (G2/M+S) 1,8 times in concentration diapason mitokorrectine (0.01-0.05 mg/ml) in comparison with control. In 3-D culture and in stationary phase we detected induction of differentiation of endothelial cells, a decrease the level of NO production and enhancement of glucose metabolism and stimulation of formation of capillary-like tubes.
authors.forename: L V
authors.initials: LV
authors.lastname: Harmanchuk
authors.forename: O M
authors.initials: OM
authors.lastname: Makarenko
authors.forename: N M
authors.initials: NM
authors.lastname: Khranovs'ka
authors.forename: T V
authors.initials: TV
authors.lastname: Nikolaienko
authors.forename: V V
authors.initials: VV
authors.lastname: Nikulina
authors.forename: Kh D
authors.initials: KhD
authors.lastname: Nepyĭvoda
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
authors.forename: S H
authors.initials: SH
authors.lastname: Morozov
authors.forename: M S
authors.initials: MS
authors.lastname: Kositsyn
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005434:Flow Cytometry; D005947:Glucose / Q000378:metabolism; D008099:Liver / Q000737:chemistry; D008928:Mitochondria / Q000737:chemistry; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D009569:Nitric Oxide / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D010179:Pancreas / Q000737:chemistry; D013552:Swine
chemical_list: D009842:Oligopeptides; D009569:Nitric Oxide; D005947:Glucose