title: Ring chromosome with deletion 7q in acute myeloid leukaemia.
abstract: Cytogenetic abnormalities can be detected in approximately 50-60% of newly diagnosed adult patients with acute myeloid leukaemia (AML). Monosomy of the chromosome 7 (-7) and deletion of the long arm of the chromosome 7 (7q-) are considered as high cytogenetic-risk AML with a poor prognosis. These abnormalities can occur, as a single chromosomal aberration, in approximately 8% of newly diagnosed AML. We report an elderly patient with AML who had deletion 7q (7q-) along with ring chromosome, which was demonstrated in conventional cytogenetics and fluoresecent in-situ hybridisation techniques.
authors.affiliation: Department of Haematology, Launceston General Hospital, Launceston, Tasmania, Australia. muhajirbm@yahoo.com
authors.forename: Muhajir
authors.initials: M
authors.lastname: Mohamed
authors.forename: Karen
authors.initials: K
authors.lastname: Dun
authors.forename: Sharad
authors.initials: S
authors.lastname: Sharma
authors.forename: Alhossain
authors.initials: A
authors.lastname: Khalafallah
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D012303:Ring Chromosomes