title: Analytical study for the charge-transfer complexes of rosuvastatin calcium with π-acceptors.
abstract: Studies were carried out to investigate the charge-transfer (CT) reaction of ROS-Ca, as a n-electron donor with various p-acceptors: tetracyanoethylene, p-chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, 2,3,5,6-tetrabromo-1,4-benzoquinone, 1,3,5-trinitrobenzene, 2,3,5,6-tetrachloro-1,4-benzoquinone, 7,7,8,8-tetracyano-quinodimethane, and 2,4,7-trinitro-9-fluorenone. Different colored CT complexes were obtained. The reaction mechanism and site of interaction were determined by ultraviolet-visible spectrophotometric techniques and computational molecular modeling. The formation of the colored complexes was utilized in the development of simple, rapid and accurate spectrophotometric methods for the determination of ROS-Ca. Under the optimum reaction conditions, linear relationships with good correlation coefficients (0.9984-0.9995) were found between the absorbances and the concentrations of ROS-Ca in the range of 2-200 mg mL⁻¹. The limits of detection ranged from 0.41 to 12.24 mg mL⁻¹. No interference could be observed from the additives commonly present in the tablets or from the drugs that are co-formulated with ROS-Ca in its combined formulations. The methods were successfully applied to the analysis of tablets with good accuracy and precision; the recovery percentages ranged from 99.54-100.46 ± 1.58-1.82%. The results were compared favorably with the reported method. The proposed methods are practical and valuable for routine application in quality control laboratories for determination of ROS-Ca in its bulk form and tablets.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors.forename: Nourah Z
authors.initials: NZ
authors.lastname: Alzoman
authors.forename: Maha A
authors.initials: MA
authors.lastname: Sultan
authors.forename: Hadir M
authors.initials: HM
authors.lastname: Maher
authors.forename: Mona M
authors.initials: MM
authors.lastname: Alshehri
authors.forename: Tanveer A
authors.initials: TA
authors.lastname: Wani
authors.forename: Ibrahim A
authors.initials: IA
authors.lastname: Darwish
mesh_terms: D000924:Anticholesteremic Agents / Q000737:chemistry* / Q000494:pharmacology; D050197:Atherosclerosis / Q000188:drug therapy; D002626:Chemistry, Pharmaceutical; D002784:Cholesterol / Q000096:biosynthesis; D005464:Fluorobenzenes / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology; D000068718:Rosuvastatin Calcium; D013053:Spectrophotometry; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000924:Anticholesteremic Agents; D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D002784:Cholesterol