title: Aptamer-modified nanoparticles as biosensors.
abstract: Aptamers are short oligonucleotides that are capable of selectively binding to their corresponding target. Therefore, they can be thought of as a nucleic acid-based alternative to antibodies and can substitute for their amino acid-based counterparts in analytical applications, including as receptors in biosensors. Here they offer several advantages because their nucleic acid nature and their binding via an induced fit mechanism enable novel sensing strategies. In this article, the utilization of aptamers as novel bio-receptors in combination with nanoparticles as transducer elements is reviewed. In addition to these analytical applications, the medical relevance of aptamer-modified nanoparticles is described.
authors.affiliation: Institut für Technische Chemie, Gottfried Wilhelm Leibniz Universität Hannover, Callinstr. 5, 30167, Hannover, Germany.
authors.forename: Maren
authors.initials: M
authors.lastname: Lönne
authors.forename: Guohong
authors.initials: G
authors.lastname: Zhu
authors.forename: Frank
authors.initials: F
authors.lastname: Stahl
authors.forename: Johanna-Gabriela
authors.initials: JG
authors.lastname: Walter
mesh_terms: D000327:Adsorption; D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000235:genetics*; D015374:Biosensing Techniques / Q000379:methods*; D008163:Luminescent Measurements / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D052156:SELEX Aptamer Technique / Q000379:methods*; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D052157:Aptamers, Nucleotide