title: Dietary exposure of the Chinese population to acrylamide.
abstract: OBJECTIVE
  To assess the current status of the acrylamide in the Chinese food supply, the dietary acrylamide exposure in the Chinese population and to estimate the public health risks of the current consumption.
  
  
  METHODS
  The acrylamide content in the total diet study (TDS) food samples was analyzed using an LC-MS/MS method. Based on the analytical results, the dietary exposure calculations were performed using a deterministic method, combining mean acrylamide concentrations from the food group composite with their associated food consumptions.
  
  
  RESULTS
  Acrylamide was detected in 43.7% of all samples collected and acrylamide concentration varied from ND to 526.6 µg/kg. The estimated dietary intakes of acrylamide among Chinese general population given as the mean and the 95th percentile (P95) were 0.286 and 0.490 µg•kg(-1) bw•day(-1), respectively. The margins of exposure (MOEs) for the population calculated using both benchmark dose lower confidence limit for a 10% extra risk of tumors in animals (BMDL10) 0.31 and 0.18 µg•kg(-1) bw•day(-1), were 1069 and 621 for the mean dietary exposure, and 633 and 367 for the high dietary exposure respectively.
  
  
  CONCLUSIONS
  These MOE values might indicate a human health concern on acrylamide for Chinese population. Efforts should continue to reduce acrylamide levels in food in order to reduce the dietary risks to the human health.
authors.affiliation: China National Center for Food Safety Risk Assessment, Beijing 100022, China.
authors.forename: Ping Ping
authors.initials: PP
authors.lastname: Zhou
authors.forename: Yun Feng
authors.initials: YF
authors.lastname: Zhao
authors.forename: Hua Liang
authors.initials: HL
authors.lastname: Liu
authors.forename: Yong Jian
authors.initials: YJ
authors.lastname: Ma
authors.forename: Xiao Wei
authors.initials: XW
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Yong Ning
authors.initials: YN
authors.lastname: Wu
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D002681:China; D004032:Diet; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000737:chemistry*; D005504:Food Analysis; D005506:Food Contamination; D006801:Humans
chemical_list: D004785:Environmental Pollutants; D020106:Acrylamide
keywords: acrylamide; assessment; dietary exposure; health risk; total diet study