title: Decoding a chain letter for degradation.
abstract: Ubiquitin chains can have distinct signaling outcomes, depending on their conjugation point. In this issue of Structure, Castañeda and colleagues describe a new structure of K11 diubiquitin and investigate its recognition by effectors to target substrates to the proteasome.
authors.affiliation: Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Christian N
authors.initials: CN
authors.lastname: Cunningham
authors.forename: Jacob E
authors.initials: JE
authors.lastname: Corn
mesh_terms: D006801:Humans; D025821:Polyubiquitin / Q000737:chemistry*
chemical_list: D025821:Polyubiquitin