title: Chemical composition and antioxidant activities in immumosuppressed mice of polysaccharides isolated from Mosla chinensis Maxim cv. jiangxiangru.
abstract: Polysaccharide MP was isolated from Mosla chinensis Maxim cv. jiangxiangru. It was composed of rhamnose, arabinose, xylose, mannose, glucose and galactose in a molar ratio of 5.364:12.260:3.448:12.260:32.567:30.651, with 11.00%±0.24% uronic acid and 9.046%±0.04% protein. Its antioxidant activity on the cyclophosphamide-induced immunosuppressed mice was investigated. The spleen and the thymus indices were investigated, and the biochemical parameters were evaluated in three organs (liver, heart and kidney). MP was able to overcome the cyclophosphamide-induced immunosuppression and can significantly raise the T-AOC, CAT, SOD and GSH-PX level. It also raised the spleen and thymus indices and decreased the MDA level in mice. MP could play an important role during the prevention process of oxidative damage in immunological system.
authors.affiliation: Nanchang University, Nanchang, China. enen928@163.com
authors.forename: Jing-En
authors.initials: JE
authors.lastname: Li
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Xie
authors.forename: Dan-Fei
authors.initials: DF
authors.lastname: Huang
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Wang
authors.forename: Chang
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D002374:Catalase / Q000378:metabolism; D045424:Complex Mixtures / Q000008:administration & dosage* / Q000737:chemistry; D003520:Cyclophosphamide / Q000276:immunology; D005979:Glutathione Peroxidase / Q000378:metabolism; D007165:Immunosuppression Therapy; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D019686:Lamiaceae / Q000276:immunology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D018384:Oxidative Stress / Q000187:drug effects; D011134:Polysaccharides / Q000008:administration & dosage* / Q000737:chemistry; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013482:Superoxide Dismutase / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects* / Q000276:immunology
chemical_list: D000975:Antioxidants; D045424:Complex Mixtures; D011134:Polysaccharides; D008315:Malondialdehyde; D003520:Cyclophosphamide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Antioxidant activity; Composition; Immunosuppression; In vivo; Mosla chinensis Maxim cv. jiangxiangru; Polysaccharides