title: Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity.
abstract: BACKGROUND
  Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is reportedly associated with peritoneal deterioration in patients treated with peritoneal dialysis (PD). However, the use of general antioxidant agents is limited due to their harmful effects. This study aimed to clarify the influence of the novel antioxidant molecular hydrogen (H2) on peritoneal OS using albumin redox state as a marker.
  
  
  METHODS
  Effluent and blood samples of 6 regular PD patients were obtained during the peritoneal equilibrium test using standard dialysate and hydrogen-enriched dialysate. The redox state of albumin in effluent and blood was determined using high-performance liquid chromatography.
  
  
  RESULTS
  Mean proportion of reduced albumin (ƒ(HMA)) in effluent was significantly higher in H2-enriched dialysate (62.31 ± 11.10%) than in standard dialysate (54.70 ± 13.08%). Likewise, serum ƒ(HMA) after administration of hydrogen-enriched dialysate (65.75 ± 7.52%) was significantly higher than that after standard dialysate (62.44 ± 7.66%).
  
  
  CONCLUSIONS
  Trans-peritoneal administration of H2 reduces peritoneal and systemic OS.
authors.affiliation: Dialysis Center, Fukushima Medical University, Fukushima, Japan. masanaka@fmu.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Terawaki
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Wan-Jun
authors.initials: WJ
authors.lastname: Zhu
authors.forename: Yukie
authors.initials: Y
authors.lastname: Matsuyama
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Terada
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kabayama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Seiichi
authors.initials: S
authors.lastname: Era
authors.forename: Bunpei
authors.initials: B
authors.lastname: Sato
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakayama