title: "Compensated hyperosmolarity" of cerebrospinal fluid and the development of hydrocephalus.
abstract: Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure. We have shown that a certain amount of (3)H₂O from the bloodstream enters osmotically loaded cerebrospinal fluid significantly faster, hence causing a significant increase in intracranial pressure. The noted phenomenon in which intracranial pressure still significantly increases, but in which the hyperosmolarity of the cerebrospinal fluid is no longer present, was named "compensated hyperosmolarity". In the case of the sub-chronic application of hyperosmolar solutions into cat ventricles, we observed an increase in cerebrospinal fluid volume and a more pronounced development of hydrocephalus in the area of application, but without significant increase in intracranial pressure and without blockage of cerebrospinal fluid pathways. These results support the newly proposed hypothesis of cerebrospinal fluid hydrodynamics and the ability to develop new strategies for the treatment of cerebrospinal fluid-related diseases.
authors.affiliation: University of Zagreb, School of Medicine, Department of Pharmacology and Croatian Institute for Brain Research, Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Klarica
authors.affiliation: University of Zagreb, School of Medicine, University Hospital for Infectious Diseases, Zagreb, Croatia.
authors.forename: B
authors.initials: B
authors.lastname: Miše
authors.affiliation: Clinical Hospital Sveti Duh, Department of Neurology, Zagreb, Croatia.
authors.forename: A
authors.initials: A
authors.lastname: Vladić
authors.affiliation: University of Zagreb, School of Medicine, Department of Pharmacology and Croatian Institute for Brain Research, Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Radoš
authors.affiliation: Ruđer Bošković Institute, Department of Molecular Biology, Zagreb, Croatia. Electronic address: doresk@irb.hr.
authors.forename: D
authors.initials: D
authors.lastname: Orešković
mesh_terms: D000818:Animals; D002415:Cats; D002552:Cerebral Ventricles / Q000503:physiopathology*; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D004285:Dogs; D006849:Hydrocephalus / Q000378:metabolism / Q000503:physiopathology*; D057446:Hydrodynamics; D007427:Intracranial Pressure; D020547:Lateral Ventricles / Q000503:physiopathology; D009997:Osmotic Pressure
keywords: cerebrospinal fluid; cerebrospinal fluid hydrodynamics; cerebrospinal fluid hyperosmolarity; hydrocephalus; intracranial pressure