title: Pattern-based sensing of peptides and aminoglycosides with a single molecular probe.
abstract: A coumarin-based molecular probe can be used for the sensing of peptides and aminoglycoside antibiotics. The probe reacts with the primary amine group(s) of the analytes to give a mixture of covalent adducts with distinct colors. Each analyte gives rise to a characteristic UV-vis spectrum. A pattern-based analysis of the spectra allows identifying structurally related analytes. Furthermore, it is possible to obtain information about the quantity and the purity of the analytes.
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
authors.forename: Boram
authors.initials: B
authors.lastname: Lee
authors.forename: Shiyu
authors.initials: S
authors.lastname: Chen
authors.forename: Christian
authors.initials: C
authors.lastname: Heinis
authors.forename: Rosario
authors.initials: R
authors.lastname: Scopelliti
authors.forename: Kay
authors.initials: K
authors.lastname: Severin
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D015335:Molecular Probes; D010455:Peptides / Q000737:chemistry*; D056951:Photoelectron Spectroscopy
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003374:Coumarins; D015335:Molecular Probes; D010455:Peptides; C030123:coumarin