title: Analysis of clinical characteristics of 516 patients with non-Hodgkin's lymphoma in Shanghai area.
abstract: The aim was to determine the clinical and cytogenetic characteristics of non-Hodgkin's lymphoma (NHL) in Shanghai. A retrospective analysis was conducted in 516 patients with NHL. Patient clinical data, including age, sex, diagnosis, immunophenotypes, and karyotypes, were collected. The median age was 58 years. There was a male predominance in all NHL, except extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Patients with B cell NHL (1.5%) expressed CD3. T cell NHL patients (11.5%) expressed CD20. Epstein-Barr virus latent integral membrane protein 1, BCL6, CD10, Bcl-2, CD68, myeloperoxidase, CD99, CD30, CD15, and CD43 were present in various types of NHL. Complex karyotypes accounted for 92.3% of the 73.7% patients with abnormal karyotypes. Immunoglobin heavy chain gene translocation was present in 60.3% of B cell and 23.7% of T/NK cell neoplasms. Understanding the complex clinicopathological and molecular features of NHL may help with prognosis and serve as targets for treatments.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Lin
authors.forename: Bobin
authors.initials: B
authors.lastname: Chen
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Xu
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Wang
authors.forename: Guowei
authors.initials: G
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D003582:Cytogenetics; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
keywords: Cytogenetic analysis; Epidemiologic studies; Fluorescence; Immunophenotyping; In situ hybridization; Lymphoma; Non-Hodgkin