title: Hepatocellular carcinoma arising in a telangiectatic hepatocellular adenoma.
abstract: Telangiectatic hepatocellular adenoma is a rare, recently recognized subtype of benign liver tumor that may very rarely undergo transformation into hepatocellular carcinoma. We report an unusual case of a 75-year-old woman with no history of oral contraceptive use that underwent malignant transformation of a telangiectactic hepatocellular adenoma. No risk factors for adenoma development were identified in this otherwise healthy woman. Radiological characteristics, gross features and histopathology are herein described. In conclusion, telangiectatic hepatocellular adenoma can undergo malignant transformation. Further studies are needed to better clarify the factors associated with malignant progression.
authors.affiliation: Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: María Fernanda
authors.initials: MF
authors.lastname: González-Lara
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Córdova-Ramón
authors.forename: Armando
authors.initials: A
authors.lastname: Gamboa-Domínguez
authors.forename: Juan
authors.initials: J
authors.lastname: Cosme-Labarthe
authors.forename: Diego Luis
authors.initials: DL
authors.lastname: Carrillo-Pérez
mesh_terms: D018248:Adenoma, Liver Cell / Q000473:pathology* / Q000601:surgery; D000368:Aged; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D012307:Risk Factors; D013684:Telangiectasis / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome