title: Prenatal exposures to perfluorinated chemicals and anthropometry at 7 years of age.
abstract: Fetal exposure to the perfluoroalkyl acids, perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA), has been associated with lower birth weight and lower weight and body mass index (weight (kg)/height (m)(2)) in early infancy. It is, however, unclear if exposure to prenatal PFOS and PFOA has a lasting influence on growth. We estimated the associations between the maternal plasma level of PFOS or PFOA and the children's body mass index, waist circumference, and risk of overweight at 7 years of age. A total of 1,400 women were randomly selected from the Danish National Birth Cohort among those who provided blood samples early in pregnancy and gave birth to liveborn singletons in 1996-2002. Weight and height information at 7 years was available for 811 children. Multiple linear and logistic regression models were used for analyses. Maternal PFOS and PFOA concentrations were overall inversely but nonsignificantly associated with the children's body mass index, waist circumference, and risk of overweight at 7 years of age. In conclusion, plasma levels of PFOS and PFOA in pregnant women did not seem to have any appreciable influence on their children's anthropometry at this point in childhood.
authors.forename: Camilla Schou
authors.initials: CS
authors.lastname: Andersen
authors.forename: Chunyuan
authors.initials: C
authors.lastname: Fei
authors.forename: Michael
authors.initials: M
authors.lastname: Gamborg
authors.forename: Ellen A
authors.initials: EA
authors.lastname: Nohr
authors.forename: Thorkild I A
authors.initials: TI
authors.lastname: Sørensen
authors.forename: Jørn
authors.initials: J
authors.lastname: Olsen
mesh_terms: D017738:Alkanesulfonic Acids / Q000009:adverse effects* / Q000097:blood; D000886:Anthropometry; D015992:Body Mass Index; D002210:Caprylates / Q000009:adverse effects* / Q000097:blood; D002648:Child; D003718:Denmark; D005260:Female; D005466:Fluorocarbons / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D050177:Overweight / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013451:Sulfonic Acids / Q000009:adverse effects* / Q000097:blood; D055105:Waist Circumference
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D005466:Fluorocarbons; D013451:Sulfonic Acids; C471071:perfluorohexanesulfonic acid; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid
keywords: body mass index; child; overweight; perfluorooctanesulfonate; perfluorooctanoate; prenatal exposure delayed effects; waist circumference