title: Visualization of thrombotic deposits in extracorporeal membrane oxygenation devices using multidetector computed tomography: a feasibility study.
abstract: Despite heparin coating and systemic anticoagulation, thrombotic clot formation is a serious complication in extracorporeal membrane oxygenation (ECMO). We describe our first results of visualization of thrombotic deposits in ECMO devices using advanced multidetector computed tomography (MDCT). A bioline-coated polymethylpentene membrane oxygenator (MO) after 8 days of ECMO treatment (device 1) and a factory-sealed MO serving as an internal quality control (device 2) were analyzed with three-dimensional (3D) visualization volume rendering technique (VRT) using a 0.6 mm3 voxel isotropic MDCT dataset. After the computed tomography (CT) scan, device 1 was anatomically dissected for direct visualization of potential deposits and further analyzed by scanning electron microscopy (SEM). The VRT 3D model based on the MDCT dataset of device 1 showed red-coded areas within the gas exchange surface of the device consistent with fibrous and cellular deposits. These deposits could be confirmed by anatomical dissection of the device and by SEM. Device 2 showed no signs of clot formation in MDCT using the same VRT settings. It was demonstrated that MDCT with VRT is able to detect thrombotic deposits in ECMO devices under ex vivo conditions. MDCT allows direct visualization of the actual thrombus load of a used ECMO device as well as the quantification of the thrombus volume and could, therefore, play a significant role in better understanding the oxygenator thrombosis in modern ECMO treatment.
authors.affiliation: Department of Radiology, University Medical Center, Regensburg, Germany. christian.dornia@ukr.de
authors.forename: Christian
authors.initials: C
authors.lastname: Dornia
authors.forename: Alois
authors.initials: A
authors.lastname: Philipp
authors.forename: Stefan
authors.initials: S
authors.lastname: Bauer
authors.forename: Patrick
authors.initials: P
authors.lastname: Hoffstetter
authors.forename: Karla
authors.initials: K
authors.lastname: Lehle
authors.forename: Christof
authors.initials: C
authors.lastname: Schmid
authors.forename: Matthias
authors.initials: M
authors.lastname: Lubnow
authors.forename: Christian
authors.initials: C
authors.lastname: Stroszczynski
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Schreyer
mesh_terms: D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects*; D005240:Feasibility Studies; D006801:Humans; D061330:Multidetector Computed Tomography; D013927:Thrombosis / Q000000981:diagnostic imaging*