title: Efficient formation of benzylic quaternary centers via palladium catalysis.
abstract: Four's a crowd: An efficient protocol for the formation of benzylic quaternary centers via arylation of enones using a catalyst made from Pd(O2 CCF3 )2 and 2,2'-bipyridine is developed. For cyclic substrates, catalyst loadings as low as 1 mol % Pd are enough to afford excellent yields (>90%) using a variety of arylboronic acids. In case of acyclic substrates, the addition of KSbF6 was found to improve conversions and yields.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen (The Netherlands).
authors.forename: Aditya L
authors.initials: AL
authors.lastname: Gottumukkala
authors.forename: Jasmin
authors.initials: J
authors.lastname: Suljagic
authors.forename: Kiran
authors.initials: K
authors.lastname: Matcha
authors.forename: Johannes G
authors.initials: JG
authors.lastname: de Vries
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard
mesh_terms: D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*
chemical_list: D010165:Palladium; D001554:Benzene
keywords: CC coupling reactions; arylations; enones; ligands; palladium