title: Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma.
abstract: Gold nanoparticles and near infrared-absorbing light are each innocuous to tissue but when combined can destroy malignant tissue while leaving healthy tissue unharmed. This study investigated the feasibility of photothermal ablation therapy for esophageal adenocarcinoma using chitosan-coated gold/gold sulfide (CS-GGS) nanoparticles. A rat esophagoduodenal anastomosis model was used for the in vivo ablation study, and three human esophageal cell lines were used to study the response of cancer cells and benign cells to near infrared light after treatment with CS-GGS. The results indicate that both cancerous tissue and cancer cells took up more gold nanoparticles and were completely ablated after exposure to near infrared light. The benign tissue and noncancerous cells showed less uptake of these nanoparticles, and remained viable after exposure to near infrared light. CS-GGS nanoparticles could provide an optimal endoluminal therapeutic option for near infrared light ablation of esophageal cancer.
authors.affiliation: Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA. yan.li@louisville.edu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Andre M
authors.initials: AM
authors.lastname: Gobin
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Dryden
authors.forename: Xinqin
authors.initials: X
authors.lastname: Kang
authors.forename: Deyi
authors.initials: D
authors.lastname: Xiao
authors.forename: Su Ping
authors.initials: SP
authors.lastname: Li
authors.forename: Guandong
authors.initials: G
authors.lastname: Zhang
authors.forename: Robert C G
authors.initials: RC
authors.lastname: Martin
mesh_terms: D055011:Ablation Techniques; D000230:Adenocarcinoma; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004938:Esophageal Neoplasms; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000970:Antineoplastic Agents; D006046:Gold
keywords: ablation; cancer; carcinoma; chitosan; drug uptake; gold nanoparticles; near infrared