title: Novel multidrug therapy for disseminated rhinosporidiosis, refractory to dapsone – case report.
abstract: Rhinosporidiosis is a chronic granulomatous disorder, caused by Rhinosporidium seeberi endemic in India and Sri Lanka. The most common sites are the nasal mucosa and the nasopharynx and cutaneous lesions usually occur as a part of disseminated rhinosporidiosis. Dapsone has been frequently used in treating disseminated disease in immunocompetent individuals. Here we report a case of disseminated rhinosporidiosis in an immunocompromised individual on antiretroviral drugs, non-responsive to Dapsone and therefore treated with a multidrug therapy of Cycloserine, Dapsone and Ketoconazole with good response.
authors.affiliation: Department of Dermatology, Christian Medical College, India. lens_grg@yahoo.com
authors.forename: Leni
authors.initials: L
authors.lastname: George
authors.forename: Peter
authors.initials: P
authors.lastname: Dincy
authors.forename: Manu
authors.initials: M
authors.lastname: Chopra
authors.forename: Manoj
authors.initials: M
authors.lastname: Agarwala
authors.forename: S
authors.initials: S
authors.lastname: Maheswaran
authors.forename: Divya
authors.initials: D
authors.lastname: Deodhar
authors.forename: Priscilla
authors.initials: P
authors.lastname: Rupali
authors.forename: Meera
authors.initials: M
authors.lastname: Thomas
authors.forename: Susanne
authors.initials: S
authors.lastname: Pulimood
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D003523:Cycloserine / Q000008:administration & dosage*; D003622:Dapsone / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012227:Rhinosporidiosis / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D003622:Dapsone; D003523:Cycloserine; D007654:Ketoconazole