title: Evaluation of cerebral circulation and oxygen metabolism in infants using near-infrared light.
abstract: Bedside monitoring of cerebral circulation or oxygen metabolism in infants to appropriately manage circulation and establish the oxygen dose, aiming at improving the neurological prognosis, is needed in general clinical practice. Near-infrared spectroscopy is used for measurements of neonatal cerebral Hb oxygen saturation, cerebral blood volume, cerebral blood flow and cerebral metabolic rate of oxygen. Near-infrared time-resolved spectroscopy is particularly useful for bedside evaluation of cerebral circulation and oxygen metabolism because of its simple measurement procedure. Combined evaluation of cerebral blood volume and cerebral Hb oxygen saturation is expected to contribute to treatment centering on the brain in neonatal medical care.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan. Electronic address: kusaka@med.kagawa-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusaka
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Isobe
authors.affiliation: Maternal Perinatal Center, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Saneyuki
authors.initials: S
authors.lastname: Yasuda
authors.affiliation: Maternal Perinatal Center, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Koyano
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Ueno
authors.affiliation: Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Miki
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Itoh
mesh_terms: D001811:Blood Volume Determination / Q000379:methods; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D010100:Oxygen
keywords: Cerebral Hb oxygen saturation; Cerebral blood flow; Cerebral blood volume; Near-infrared spectroscopy; Near-infrared time-resolved spectroscopy; Neonates