title: Effects of femara and tamoxifen on proliferation of FM3A cells in culture.
abstract: In this study, antiproliferative effects of the selective estrogen receptor modulator Tamoxifen and the aromatase inhibitor letrozole (Femara) were evaluated and compared using the FM3A cell line, originating from a C3H mouse mammary carcinoma and positive in terms of estrogen receptor (ER) expression. Cell kinetic parameters including labelling index, mitotic index and labelling index were assessed after exposure of the. FM3A cell line to 0.001μg/ml of Tamoxifen and 0.25μg/ml of Femara for 4, 8, 16 and 32 h for all parameters. The results showed that cell growth was inhibited by both agents. There was a significant decrease in labelling index and mitotic index and significant increase in apoptotic index for all experimental groups. The differences between control and all experimental groups were statistically significant (p<0.001) for all applications.
authors.affiliation: Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey. topcul@istanbul.edu.tr
authors.forename: Mehmet
authors.initials: M
authors.lastname: Topcul
authors.forename: Funda
authors.initials: F
authors.lastname: Topcul
authors.forename: Idil
authors.initials: I
authors.lastname: Cetin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D047072:Aromatase Inhibitors / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D000077289:Letrozole; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D008940:Mitotic Index; D009570:Nitriles / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000096:biosynthesis; D013629:Tamoxifen / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors; D004965:Estrogen Antagonists; D009570:Nitriles; D011960:Receptors, Estrogen; D014230:Triazoles; D013629:Tamoxifen; D000077289:Letrozole