title: Non-covalent synthesis of metal oxide nanoparticle-heparin hybrid systems: a new approach to bioactive nanoparticles.
abstract: Heparin has been conjugated to Fe3O4, Co3O4, and NiO nanoparticles (NPs) through electrostatic interactions, producing colloidal suspensions of hybrid metal oxide heparin NPs that are stable in water. Negative zeta potentials and retention of heparin's ability to capture toluidine blue indicate that heparin's negative charges are exposed on the surface of the coated NPs. IR results confirmed the formation of nanohybrids as did NMR experiments, which were also interpreted on the basis of toluidine blue tests. Transmission electron microscopy results revealed that the heparin coating does not modify the shape or dimension of the NPs. Dynamic light scattering and negative zeta potential measurements confirmed that heparin surface functionalisation is an effective strategy to prevent NP aggregation.
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering "G. Natta" Polytechnic, 7 Mancinelli Street, 20131 Milan, Italy. elena.vismara@polimi.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Vismara
authors.forename: Antonio
authors.initials: A
authors.lastname: Valerio
authors.forename: Alessia
authors.initials: A
authors.lastname: Coletti
authors.forename: Giangiacomo
authors.initials: G
authors.lastname: Torri
authors.forename: Sabrina
authors.initials: S
authors.lastname: Bertini
authors.forename: Giorgio
authors.initials: G
authors.lastname: Eisele
authors.forename: Rosalba
authors.initials: R
authors.lastname: Gornati
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bernardini
mesh_terms: D003102:Colloids / Q000737:chemistry; D006493:Heparin; D019216:Metals, Heavy / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D055672:Static Electricity
chemical_list: D003102:Colloids; D019216:Metals, Heavy; D010087:Oxides; D006493:Heparin