title: Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition.
abstract: Degradable metals have been suggested as biomaterials with revolutionary potential for bone-related therapies. Of these candidate metals, magnesium alloys appear to be particularly attractive candidates because of their non-toxicity and outstanding mechanical properties. Despite their having been widely studied as orthopedic implants for bone replacement/regeneration, their undesirably rapid corrosion rate under physiological conditions has limited their actual clinical application. This study reports the use of a novel biomimetic peptide coating for Mg alloys to improve the alloy corrosion resistance. A 3DSS biomimetic peptide is designed based on the highly acidic, bioactive bone and dentin extracellular matrix protein, phosphophoryn. Surface characterization techniques (scanning electron microscopy, energy dispersive X-ray spectroscopy and diffuse-reflectance infrared spectroscopy) confirmed the feasibility of coating the biomimetic 3DSS peptide onto Mg alloy AZ31B. The 3DSS peptide was also used as a template for calcium phosphate deposition on the surface of the alloy. The 3DSS biomimetic peptide coating presented a protective role of AZ31B in both hydrogen evolution and electrochemical corrosion tests.
authors.affiliation: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: W
authors.initials: W
authors.lastname: Cui
authors.forename: E
authors.initials: E
authors.lastname: Beniash
authors.forename: E
authors.initials: E
authors.lastname: Gawalt
authors.forename: Z
authors.initials: Z
authors.lastname: Xu
authors.forename: C
authors.initials: C
authors.lastname: Sfeir
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D000595:Amino Acid Sequence; D040761:Biomimetic Materials / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000494:pharmacology*; D011232:Chemical Precipitation; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003343:Corrosion; D016326:Extracellular Matrix Proteins / Q000737:chemistry; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D007477:Ions / Q000097:blood; D008274:Magnesium / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology; D010750:Phosphoproteins / Q000737:chemistry; D012795:Sialoglycoproteins / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013055:Spectrophotometry, Infrared; D000099311:Dentin Sialophosphoprotein
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D016326:Extracellular Matrix Proteins; D006859:Hydrogen; D007477:Ions; D008274:Magnesium; D010455:Peptides; D010750:Phosphoproteins; D012795:Sialoglycoproteins; D000099311:Dentin Sialophosphoprotein; C020243:calcium phosphate
keywords: Biomimetic coating; Calcium phosphate; Corrosion; Electrochemical corrosion; Magnesium alloys