title: Double blind randomized clinical trial controlled by placebo with a fos enriched cookie on saciety and cardiovascular risk factors in obese patients.
abstract: BACKGROUND
  It is essential to determine which snack foods are most affective for appetite control. The objective of the current study was to assess the responses of two different cookies on satiety and cardiovascular risk factors.
  
  
  METHODS
  38 patients were randomized: group I (FOS enriched cookie, n=19) and group II (control cookie, n=19). Previous and after 1 month , the subjects rated their feelings of satiety/hunger with a test meal of 5 cookies.
  
  
  RESULTS
  After the test meal, the basal area under curve of the first hunger/satiety score was higher with satiety cookie than with control cookie, the data after 1 month of treatment was higher with satiety cookie than with control cookie, too. The score was higher than the fasting level for 20 minutes with satiety cookie and for 40 minutes with the same cookie, too. In satiety group, these scores (20 min and 40 min) were higher than control group before and after 1 month of treatment. The results were in the same way with the 100 mm 5-point visual satiety scale. Cardiovascular risk factors and dietary intake remained unchanged after dietary intervention.
  
  
  CONCLUSIONS
  A FOS enriched cookie produced greater ratings of satiety than a control cookie, without effects on cardiovascular risk factors or dietary intakes.
authors.affiliation: Facultad de Medicina y Unidad de Apoyo a la Investigación, Instituto de Endocrinología y Nutrición, Hospital Río Hortega, Universidad de Valladolid, Simancas, Valladolid. dadluis@yahoo.es
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.forename: B
authors.initials: B
authors.lastname: de la Fuente
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.forename: S
authors.initials: S
authors.lastname: Gutiérrez
authors.forename: María
authors.initials: M
authors.lastname: Morillo
mesh_terms: D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects*; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000453:epidemiology / Q000523:psychology*; D009844:Oligosaccharides / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D012307:Risk Factors; D018401:Sample Size; D012528:Satiety Response / Q000187:drug effects*; D055815:Young Adult
chemical_list: D008055:Lipids; D009844:Oligosaccharides