title: Successful treatment of pain in melorheostosis with zoledronate, with improvement on bone scintigraphy.
abstract: Melorheostosis is a very rare sclerosing bone disorder that involves frequently one limb. It may be asymptomatic, but pain and limb deformity may occur and can be very debilitating. Different reports have indicated efficacy of bisphosphonates (pamidronate and etidronate) on symptoms. We report an adult patient with a very painful melorheostosis, who  improved after treatment with zoledronate, either on symptoms or on bone scans.
authors.affiliation: Department of Medicine, Hadj Lakhdar University, Batna, Algeria. slimani@dr.com
authors.forename: Samy
authors.initials: S
authors.lastname: Slimani
authors.forename: Adlen
authors.initials: A
authors.lastname: Nezzar
authors.forename: Hachemi
authors.initials: H
authors.lastname: Makhloufi
mesh_terms: D000328:Adult; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008557:Melorheostosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D059352:Musculoskeletal Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D011877:Radionuclide Imaging; D016896:Treatment Outcome; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid