title: Highly efficient synthesis of mixed 3,3'-bisindoles via Rh(II)-catalyzed three-component reaction of 3-diazooxindoles with indoles and ethyl glyoxylate.
abstract: A series of mixed 3,3'-bisindoles were efficiently synthesized via a Rh2(OAc)4-catalyzed three-component reaction of 3-diazooxindoles with indoles and ethyl glyoxylate in high yields with excellent diastereoselectivities. The product easily underwent further synthetic transformations and could be potentially applied to the total synthesis of (±)-gliocladin C and related natural alkaloids.
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China. dxing@sat.ecnu.edu.cn
authors.forename: Dong
authors.initials: D
authors.lastname: Xing
authors.forename: Changcheng
authors.initials: C
authors.lastname: Jing
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Li
authors.forename: Huang
authors.initials: H
authors.lastname: Qiu
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D006038:Glyoxylates / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001391:Azo Compounds; D006038:Glyoxylates; D007211:Indoles; D012428:Ruthenium