title: Clinical Subtypes of Frontotemporal Dementia.
abstract: Frontotemporal dementia (FTD) was one of the lesser known dementias until the recent advancements revealing its genetic and pathological foundation. This common neurodegenerative disorder has three clinical subtypes- behavioral, semantic and progressive non fluent aphasia. The behavioral variant mostly exhibits personality changes, while the other two encompass various language deficits. This review discusses the basic pathology, genetics, clinical and histological presentation and the diagnosis of the 3 subtypes. It also deliberates the different therapeutic modalities currently available for frontotemporal dementia and the challenges faced by the caregivers. Lastly it explores the scope of further research into the diagnosis and management of FTD.
authors.affiliation: Department of Neurology, Drexel University College of Medicine, Philadelphia, PA, USA 87sayantani@gmail.com.
authors.forename: Sayantani
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Neurology, Drexel University College of Medicine, Philadelphia, PA, USA.
authors.forename: Carol F
authors.initials: CF
authors.lastname: Lippa
mesh_terms: D001519:Behavior / Q000502:physiology*; D017028:Caregivers / Q000523:psychology; D003937:Diagnosis, Differential; D057180:Frontotemporal Dementia / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D020774:Pick Disease of the Brain / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics
keywords: behavioral variant; frontotemporal dementia; genetics; management; pathology; progressive non-fluent aphasia; semantic dementia