title: Peroxisome interactions and cross-talk with other subcellular compartments in animal cells.
abstract: Peroxisomes are remarkably plastic and dynamic organelles, which fulfil important functions in hydrogen peroxide and lipid metabolism rendering them essential for human health and development. Despite great advances in the identification and characterization of essential components and molecular mechanisms associated with the biogenesis and function of peroxisomes, our understanding of how peroxisomes are incorporated into metabolic pathways and cellular communication networks is just beginning to emerge. Here we address the interaction of peroxisomes with other subcellular compartments including the relationship with the endoplasmic reticulum, the peroxisome-mitochondria connection and the association with lipid droplets. We highlight metabolic cooperations and potential cross-talk and summarize recent findings on peroxisome-peroxisome interactions and the interaction of peroxisomes with microtubules in mammalian cells.
authors.affiliation: College of Life and Environmental Sciences, Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, UK, m.schrader@exeter.ac.uk.
authors.forename: Michael
authors.initials: M
authors.lastname: Schrader
authors.forename: Sandra
authors.initials: S
authors.lastname: Grille
authors.forename: H Dariush
authors.initials: HD
authors.lastname: Fahimi
authors.forename: Markus
authors.initials: M
authors.lastname: Islinger
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008928:Mitochondria / Q000378:metabolism; D020675:Peroxisomes / Q000378:metabolism*; D015398:Signal Transduction