title: The role of fibrin glue in the treatment of high and low fistulas in ano.
abstract: OBJECTIVE
  The aim of this study was to assess the outcome of fibrin glue in high and low anal fistulas.
  
  
  METHODS
  A prospective, non-randomized trial was carried out on 30 patients who were diagnosed to have fistulas in ano. They were evaluated by categorizing them into high (with the internal opening above the anorectal ring)(14/30) and low anal fistulas (with the internal opening below the anorectal ring)(16/30). The fibrin glue was instilled in their anal tracts. The character of the anal tract, whether it was single or multiple and primary or recurrent, was analyzed. The outcome in terms of a postoperative discharge (failure), the incidence of a postoperative perianal pain/abscess and the glue reaction, was noted at 1 week, 1 month, 3 months and 6 months. A success was defined as the absence of any discharge at 6 months.
  
  
  RESULTS
  Fourteen patients with high anal fistulas and 16 with low anal fistulas (with a mean age of 48.5yrs) were treated with fibrin glue. 19 patients had primary tracts (7- high group and 12- low group) and 11 had recurrent tracts (7- high group and 4- low group). 20 fistulas were single tracted (8- high and 12- low) and ten were multiple tracted (6- high and 4-low). The success rate at 6 months was 57.14% in the high group and it was 81.25% in the low group. The failure rate was 85.71% in the recurrent high fistula group as compared to 25% in the recurrent low fistula group (p=0.049). 25% of the single tracted high fistulas failed to heal as compared to a 100% healing rate in the single low fistulas group (p=0.90).
  
  
  CONCLUSIONS
  This procedure is thus, superior to the conventional surgical treatment, in terms of the patient comfort, an undisturbed sphincter function, a reduced overall hospital stay, wound pain and the complications and adverse reactions. It showed the best results in the primary, single tracted and the low anal fistulas.
authors.affiliation: Professor, Department of Surgery.
authors.forename: Atul
authors.initials: A
authors.lastname: Mishra
authors.forename: Sheerin
authors.initials: S
authors.lastname: Shah
authors.forename: Amandeep Singh
authors.initials: AS
authors.lastname: Nar
authors.forename: Ashvind
authors.initials: A
authors.lastname: Bawa
keywords: Failed fistula; Fibrin glue; Fistula in ano; Recurrenct fistula