title: Development and reliability of a correction factor for family-reported medication adherence: pediatric inflammatory bowel disease as an exemplar.
abstract: OBJECTIVE
  To examine the issue of accurate adherence assessment and illustrate methodologies for correcting parent-reported medication adherence.
  
  
  METHODS
  40 children with inflammatory bowel disease provided medication adherence data using electronic monitoring. Parents provided subjective reports of medication adherence. Receiver operating characteristic analyses were used to examine the detection of non-adherence at several adherence cut-points. 2 methods for empirically deriving a correction factor for subjectively reported adherence were applied.
  
  
  RESULTS
  Although parent-report and EM adherence were significantly correlated, parent-reported adherence was significantly higher than EM adherence. A 90% cut-point provided the highest sensitivity and specificity. Both correction factors reliably adjusted parent-reported adherence based on EM adherence.
  
  
  CONCLUSIONS
  Application of an empirically derived correction factor for parent-reported adherence using methodologies, such as those illustrated in the current study, could yield more accurate adherence assessment. Obtaining more accurate adherence assessments based on parent-report will have implications for self-management interventions, clinician prescribing behavior, and medication safety.
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Center for Adherence and Self-Management, MLC-7039, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
authors.forename: Yelena P
authors.initials: YP
authors.lastname: Wu
authors.forename: Ahna L H
authors.initials: AL
authors.lastname: Pai
authors.forename: Wendy N
authors.initials: WN
authors.lastname: Gray
authors.forename: Lee A
authors.initials: LA
authors.lastname: Denson
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Hommel
mesh_terms: D000293:Adolescent; D002648:Child; D005190:Family / Q000523:psychology; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D056656:Lab-On-A-Chip Devices; D008297:Male; D011594:Psychometrics / Q000295:instrumentation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires / Q000592:standards*; D016903:Drug Monitoring
keywords: compliance; measurement; medication-taking; nonadherence; self-management