title: Comparison 30-day clinical complications between transfemoral versus transapical aortic valve replacement for aortic stenosis: a meta-analysis review.
abstract: BACKGROUND
  Since 2002, transapical aortic valve replacement has been developed as a clinical pathway for transcatheter aortic valve implantation (TAVI). However the appropriate role of TA in the AS population versus TF remains unclear. We performed a meta-analysis to assess if TF has any benefit in reduction of 30-day clinical complications in AS.
  
  
  METHODS
  We conducted a comprehensive search on pub-med and web of knowledge from 2002 through September 2012 using following terms: aortic stenosis, aortic valve replacement, transcatheter aortic valve implantation, TAVI, trans-artery, transfemoral, trans-apical. Studies in the original research or review articles were also considered. Included studies must meet the preconditioned criterias. Two investigators independently browsed the studies by title and abstract, finally making decision according to full-text. Disagreements were discussed in group.
  
  
  RESULTS
  A total of 20 studies met inclusion criteria's and were included in the analysis (including 4267 patients in TF group, 2242 in TA group). No random clinical trial, one was a retrospective study, others were prospective trials. Our meta-analysis found that TF had the low incidence of 30-day mortality compared with TA procedure (7.5% versus 11.3%). The incidence of stroke at ≤ 30 days was relatively low (3.8% in TF versus 4.0% in TA). Although the incidence of post-operative heart block was high (8.5% versus 7.5%), but no differences were indicated [1.06,95% CI(0.85,1.33)].
  
  
  CONCLUSIONS
  The result of our meta-analysis suggested that TF may have a low risk for 30-day mortality against TA procedure. No difference was found in the incidence of post-operative stroke and heart block.
authors.affiliation: Cardiaovascular surgery, Department of second affiliated hospital, school of Medicine, Zhejiang university, No, 88, Jie fang road, Hangzhou, Zhejiang province 310009, China.
authors.forename: Xuebiao
authors.initials: X
authors.lastname: Li
authors.forename: Minjian
authors.initials: M
authors.lastname: Kong
authors.forename: Daming
authors.initials: D
authors.lastname: Jiang
authors.forename: Aiqiang
authors.initials: A
authors.lastname: Dong
mesh_terms: D001024:Aortic Valve Stenosis / Q000401:mortality / Q000601:surgery*; D005263:Femoral Artery; D019918:Heart Valve Prosthesis Implantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D007083:Iliac Artery; D011183:Postoperative Complications; D012307:Risk Factors