title: The Golgi Apparatus: Panel Point of  Cytosolic Ca(2+) Regulation.
abstract: The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca(2+) store because different Ca (2+) regulators, such as the inositol-1,4,5-triphosphate receptor, sarco/endoplasmic reticulum Ca(2+) -ATPase and secretory pathway Ca 2+ -ATPase, were demonstrated to localize on their membrane. The mechanisms involved in Ca(2+) release and uptake in the GA have now been established.Here, based on careful backward looking on compartments and patterns in GA Ca (2+) regulation, we review neurological diseases related to GA calcium remodeling and propose a modified cytosolic Ca(2+) adjustment model, in which GA acts as part of the panel point.
authors.affiliation: Department of Neurology, Second Xiangya Hospital, Central-South University, Changsha; School of Medicine, Jishou University, Jishou , PR China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Li
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Tian
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiang
authors.forename: Liu-Wang
authors.initials: LW
authors.lastname: Zeng
authors.forename: Wen-Fang
authors.initials: WF
authors.lastname: He
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Hu
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism*; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000502:physiology; D012871:Skin Diseases / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D002118:Calcium