title: A metal-free tandem demethylenation/C(sp2)-H cycloamination process of N-benzyl-2-aminopyridines via C-C and C-N bond cleavage.
abstract: A mild, metal-free synthesis of pyrido[1,2-a]benzimidazoles starting with N-benzyl-2-aminopyridines, which employs PhI(OPiv)2 as a stoichiometric oxidant, has been developed. The process is initiated by an unusual PhI(OPiv)2-mediated ipso S(E)Ar reaction, followed by solvent-assisted C-C and C-N bond cleavage.
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Liang
authors.forename: Yimiao
authors.initials: Y
authors.lastname: He
authors.forename: Lanying
authors.initials: L
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D000631:Aminopyridines / Q000138:chemical synthesis* / Q000737:chemistry; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*
chemical_list: D000631:Aminopyridines; D001593:Benzyl Compounds; D008670:Metals; D016877:Oxidants; D002244:Carbon