title: Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis.
abstract: Endometriosis is one of the most frequent gynecological diseases. In addition to their side effects, available medical therapies may decrease fertility. Current understanding of endometriosis focuses on the role of the immune system in its pathophysiology. Recent research shed light on the immunomodulatory effect of vitamin D3. Thus, this study was designed to study the effect of vitamin D3 on regression of endometriotic implants in a rat surgical model. Vitamin D3 reduced cyst cross sectional area by 48.8%. Histologically, vitamin D treatment produced fibrosis as well as apoptosis in the stroma. The results of the present study suggest that vitamin D3 administration may have a beneficial effect in treating endometriosis.
authors.affiliation: Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan. manabbas@yahoo.com
authors.forename: Manal A
authors.initials: MA
authors.lastname: Abbas
authors.forename: Mutasem O
authors.initials: MO
authors.lastname: Taha
authors.forename: Ahmad M
authors.initials: AM
authors.lastname: Disi
authors.forename: Maha
authors.initials: M
authors.lastname: Shomaf
mesh_terms: D000818:Animals; D002762:Cholecalciferol / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D005260:Female; D051381:Rats
chemical_list: D002762:Cholecalciferol
keywords: Cholecalciferol; Endometriosis; Rat surgical model; Vitamin D(3)