title: [Prehospital treatment with bivalirudin in acute myocardial infarction referred for primary angioplasty. About 152 consecutive patients study].
abstract: OBJECTIVE
  Bivalirudin, a direct thrombin inhibitor, demonstrated an improvement in the prognosis of acute coronary syndromes by a decrease in major bleeding complications. This observational study evaluated inhospital outcome of patients with acute myocardial infarction treated by prehospital bivalirudin before primary angioplasty.
  
  
  METHODS
  We included, from June 2010 to June 2012, all patients with acute myocardial infarction receiving prehospital bivalirudin with bolus of 0.75mg/kg followed by an infusion of 1.75mg/kg per hour until the arrival in the catheterization laboratory. Bivalirudin was possibly continued after primary angioplasty.
  
  
  RESULTS
  We included 152 patients aged 57.6±11.6 years. A prehospital 60mg loading dose of prasugrel was given in 77% of patients. Coronary angiography with radial access (77.6%) was performed before a successful angioplasty in 97.3% of cases. The bivalirudin infusion was continued after the procedure in 81.6% of patients. Inhospital outcome showed two deaths (1.3%) and two re-infarctions (1.3%) of which one was related to the single acute stent thrombosis (0.6%). Major bleeding complications were limited irrespective of the Gusto (0.6%), Timi (0.6%) or Horizons-MI (4.6%) classification. Bleeding complications rate was similar when bivalirudin was followed or not after primary angioplasty.
  
  
  CONCLUSIONS
  The use of bivalirudin in the prehospital setting for primary angioplasty seems to be effective and safe about ischemic and bleeding complications during the inhospital outcome.
authors.affiliation: Service de cardiologie, centre hospitalier Émile-Muller, 20, rue du Docteur-Laennec, BP 1370, 68070 Mulhouse cedex, France. Electronic address: jacqueminl@ch-mulhouse.fr.
authors.forename: L
authors.initials: L
authors.lastname: Jacquemin
authors.forename: O
authors.initials: O
authors.lastname: Roth
authors.forename: J-Y
authors.initials: JY
authors.lastname: Wiedemann
authors.forename: W
authors.initials: W
authors.lastname: Yafi
authors.forename: Y
authors.initials: Y
authors.lastname: Hadjij
authors.forename: R
authors.initials: R
authors.lastname: Le Bouard
authors.forename: J
authors.initials: J
authors.lastname: Lévy
mesh_terms: D000368:Aged; D017130:Angioplasty; D000991:Antithrombins / Q000008:administration & dosage / Q000627:therapeutic use*; D017023:Coronary Angiography; D004632:Emergency Medical Services / Q000379:methods; D005260:Female; D006629:Hirudins / Q000008:administration & dosage; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy; D010446:Peptide Fragments / Q000008:administration & dosage / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000991:Antithrombins; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C074619:bivalirudin
keywords: Angioplastie; Angioplasty; Bivalirudin; Bivalirudine; Infarction; Infarctus; Prehospital; Préhospitalier