title: Biosynthesis of the natural fluorophore legioliulin from legionella.
abstract: Let it shine: The biosynthesis of the UV fluorophore legioliulin (1) from Legionella spp. was elucidated and the phenylalanine ammonium lyase LglD responsible for the formation of the starter unit cinnamic acid was biochemically characterized. Additionally, two novel derivatives differing in the starter unit have been identified by mutasynthesis experiments.
authors.affiliation: Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
authors.forename: Tilman
authors.initials: T
authors.lastname: Ahrendt
authors.forename: Melissa
authors.initials: M
authors.lastname: Miltenberger
authors.forename: Ina
authors.initials: I
authors.lastname: Haneburger
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Kirchner
authors.forename: Max
authors.initials: M
authors.lastname: Kronenwerth
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Brachmann
authors.forename: Hubert
authors.initials: H
authors.lastname: Hilbi
authors.forename: Helge B
authors.initials: HB
authors.lastname: Bode
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002934:Cinnamates / Q000737:chemistry; D003374:Coumarins / Q000378:metabolism*; D007875:Legionella / Q000235:genetics* / Q000378:metabolism*; D015394:Molecular Structure; D005810:Multigene Family; D010650:Phenylalanine Ammonia-Lyase / Q000737:chemistry / Q000235:genetics
chemical_list: D002934:Cinnamates; D003374:Coumarins; C493787:legioliulin; C029010:cinnamic acid; D010650:Phenylalanine Ammonia-Lyase
keywords: Legionella; biosynthesis; mutagenesis