title: A sugar-functionalized amphiphilic pillar[5]arene: synthesis, self-assembly in water, and application in bacterial cell agglutination.
abstract: A novel sugar-functionalized amphiphilic pillar[5]arene containing galactose groups as the hydrophlic part and alkyl chains as the hydrophobic part was designed and synthesized. It self-assembles in water to produce nanotubes as confirmed by TEM, SEM, and fluorescence microscopy. These nanotubes, showing low toxicity to both cancer and normal cells, can be utilized as excellent cell glues to agglutinate E. coli. The existence of galactoses on these nanotubes provides multivalent ligands that have high affinity for carbohydrate receptors on E. coli.
authors.affiliation: Department of Chemistry, MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Guocan
authors.initials: G
authors.lastname: Yu
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Ma
authors.forename: Chengyou
authors.initials: C
authors.lastname: Han
authors.forename: Yong
authors.initials: Y
authors.lastname: Yao
authors.forename: Guping
authors.initials: G
authors.lastname: Tang
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Mao
authors.forename: Changyou
authors.initials: C
authors.lastname: Gao
authors.forename: Feihe
authors.initials: F
authors.lastname: Huang
mesh_terms: D047250:Calixarenes; D002241:Carbohydrates / Q000737:chemistry*; D002449:Cell Aggregation / Q000187:drug effects*; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects*; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002241:Carbohydrates; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; C570642:pillar(5)arene; D047250:Calixarenes