title: [Research progress on genome-wide association studies of colorectal cancer].
abstract: Colorectal cancer (CRC), one of the most common malignant tumors, is caused both by environmental and genetic factors. Genetic factor plays an important role in the pathogenesis of CRC. Genome-wide association study (GWAS) is a new tool of genetic research. A series of susceptibility genes and loci of the complex diseases has been identified with GWAS strategy. In this article, the research progress on GWAS of CRC is reviewed, and the advantages and limitations of GWAS study as well as the prospective of its application are discussed.
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Maode
authors.initials: M
authors.lastname: Lai
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide