title: Abnormal auditory sensory gating-out in first-episode and never-medicated paranoid schizophrenia patients: an fMRI study.
abstract: Numerous electrophysiological studies have showed auditory sensory gating-out abnormalities in chronic schizophrenia with antipsychotic medication. Previous research has used functional magnetic resonance imaging (fMRI) with excellent spatial resolution to identify the neural substrates of sensory gating-out deficits revealing increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex. However, such results obtained from medicated patients may be confounded by antipsychotic medication. The present study scanned 15 first-episode schizophrenia patients not yet receiving any medical treatment and 15 healthy controls matched in gender, age and education when they performed a sensory gating-out task adapted for fMRI. The symptoms of the patients were assessed with the positive and negative syndrome scale. Different from previous findings, the schizophrenia patients showed decreased activation in hippocampus and thalamus during sensory gating-out, compared with the normal controls. The results support the theory attributing abnormal sensory gating-out in schizophrenia patients to the dysfunction of hippocampus and thalamus.
authors.affiliation: Guangdong Key Laboratory of Medical Molecular Imaging, The First Affiliated Hospital of the Medical College of Shantou University, Changping Road, Shantou 515041, Guangdong, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Ji
authors.forename: Wei
authors.initials: W
authors.lastname: Mei
authors.forename: John X
authors.initials: JX
authors.lastname: Zhang
authors.forename: Juzhen
authors.initials: J
authors.lastname: Jing
authors.forename: Qiulin
authors.initials: Q
authors.lastname: Wu
authors.forename: Yongning
authors.initials: Y
authors.lastname: Zhuo
authors.forename: Zhuangwei
authors.initials: Z
authors.lastname: Xiao
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012563:Schizophrenia, Paranoid / Q000188:drug therapy* / Q000503:physiopathology; D055139:Sensory Gating / Q000187:drug effects* / Q000502:physiology; D013788:Thalamus / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents