title: [The characteristics of production of cytokines in patients with tuberculosis of lungs].
abstract: The sample of 36 patients with primarily diagnosed mostly infiltrative tuberculosis of lungs was used to investigate the characteristics of spontaneous and stimulated by specific antigens production of cytokines FNO-alpha, IFN-beta, IL-8 playing the most significant role in pathogenesis of tuberculosis. The production of FNO-alpha and IFN-gamma was analyzed in the culture of peripheral mononuclear cells using antigen M. bovis (BCG). The cytokines IFN-gamma and IL-8 were analyzed in the cultures of whole heparinized blood using antigens H37Rv and ESAT-6. The significant inhibition of stimulated by antigens production of FNO-alpha and IFN-gamma in patients with severe, destructive and complicated forms of tuberculosis as compared with to patients with limited and favorably developing tuberculosis. The differences in production of lL-8 in patients with different degree of severity of tuberculosis process are not revealed.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Salina
authors.forename: T I
authors.initials: TI
authors.lastname: Morozova
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000472:pathogenicity; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity; D014376:Tuberculosis / Q000097:blood* / Q000382:microbiology / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma