title: The long-term course of functional and anatomical recovery after macular hole surgery.
abstract: OBJECTIVE
  To investigate the long-term effect of macular hole surgery, foveal structure and the thickness of retinal layers were analyzed with spectral-domain optical coherence tomography (SD-OCT). The long-term postoperative course of macular thickness and best-corrected visual acuity (BCVA) were followed.
  
  
  METHODS
  In a retrospective cohort study, SD-OCT scans were obtained from the horizontal midline in 51 eyes 54±20 months postoperatively and from 30 control eyes. Retinal layer thickness was measured with a manual segmentation procedure aided by a customized computer program. BCVA was followed and macular thickness was quantified over time with the time-domain (TD) OCT Fast Macular Thickness program for up to 91 months.
  
  
  RESULTS
  Median foveal thickness between the outer plexiform and ganglion cell layers was greater than normal while that of the other retinal layers was normal. The median foveal shape remained slightly distorted. The postoperative decrease of central macular thickness toward normal values was delayed to 28 months postoperatively. Nasal macular thickness was decreased to normal at 6 months while superior, temporal, and inferior macular thickness was decreased to normal at 1 to 2 months postoperatively. Preoperative mean BCVA was 20/100±3 lines. Postoperatively, mean BCVA was 20/44±2 lines at 3 to 6 months, 20/40±2 lines at 1 year, 20/32±2 lines at 2 years, and 20/28±1 line after a mean follow-up period of 54±20 months.
  
  
  CONCLUSIONS
  Long-term postoperatively, the median thickness of retinal layers remains slightly thickened between the outer plexiform and the ganglion cell layer. The process of gradual recovery may continue for several years after macular hole surgery.
authors.affiliation: Department of Ophthalmology, University Medical Center Schleswig-Holstein, Kiel, Germany.
authors.forename: Konstantine
authors.initials: K
authors.lastname: Purtskhvanidze
authors.forename: Felix
authors.initials: F
authors.lastname: Treumer
authors.forename: Olaf
authors.initials: O
authors.lastname: Junge
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hedderich
authors.forename: Johann
authors.initials: J
authors.lastname: Roider
authors.forename: Jost
authors.initials: J
authors.lastname: Hillenkamp
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005584:Fovea Centralis; D006801:Humans; D008266:Macula Lutea; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012165:Retinal Ganglion Cells / Q000473:pathology; D012167:Retinal Perforations / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology*; D014821:Vitrectomy
keywords: macular hole; optical coherence tomography; retinal layers