title: Magnetic Resonance Spectroscopy Study of Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment With No Dementia.
abstract: Amnestic mild cognitive impairment (aMCI) and vascular cognitive impairment with no dementia (VCIND) are highly predictive of Alzheimer's disease and vascular dementia. In this study, a 2-dimensional magnetic resonance spectroscopy was performed in 25 patients with aMCI, 28 patients with VCIND, and 32 normal controls (NCs). The concentrations of N-acetyl aspartate (NAA), choline (Cho), myoinositol (MI), and creatine (Cr) were measured, and their ratios were calculated. The patients with aMCI displayed significantly lower NAA/MI bilaterally in the posterior cingulate gyrus (PCG) and white matter of occipital lobe (OLWM) than NC participants or patients with VCIND , whereas patients with VCIND displayed markedly lower NAA/Cho bilaterally in the white matter of frontal lobe (FLWM) and left OLWM, and right dorsal thalamus (DT) than patients with NC or aMCI. Compared with the controls, patients with aMCI displayed lower NAA and NAA/Cr in bilateral PCG, left precuneus, and DT, whereas patients with VCIND displayed lower NAA/Cr in bilateral DT and FLWM. In addition, increased MI in right PCG of patients with aMCI and increased Cho in left FLWM of patients with VCIND were also observed. The results might help guide a clinical differentiation between the 2 disorders.
authors.affiliation: Department of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Liu
authors.affiliation: Department of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
authors.forename: Zhong-Xian
authors.initials: ZX
authors.lastname: Yang
authors.affiliation: Department of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Shen
authors.affiliation: Department of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
authors.forename: Ye-Yu
authors.initials: YY
authors.lastname: Xiao
authors.affiliation: Department of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Cheng
authors.affiliation: Department of Neurology, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
authors.forename: Yao-Wen
authors.initials: YW
authors.lastname: Chen
authors.affiliation: Department of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China Provincial Key Laboratory of Medical Molecular Imaging, Guangdong, Shantou, China rhwu@stu.edu.cn.
authors.forename: Ren-Hua
authors.initials: RH
authors.lastname: Wu
mesh_terms: D000368:Aged; D000647:Amnesia / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D003072:Cognition Disorders / Q000000981:diagnostic imaging*; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged
keywords: MR spectroscopy; amnesic mild cognitive impairment; vascular cognitive impairment with no dementia