title: Impressive shrinkage of a giant prolactinoma treated with cabergoline in a prepubescent girl. What now?
abstract: Giant prolactinomas are extremely rare in the pediatric population. We describe the case of a giant prolactinoma in a girl aged 14 years and 9 months old presented with delayed puberty. Medical treatment with dopamine agonist cabergoline resulted in a rapid normalization of prolactine levels and an impressive shrinkage and liquefaction of the mass as illustrated in serial MRIs. The therapeutic dilemma regarding the type of treatment (medical versus surgical) has now been replaced by the dilemma regarding the optimal treatment strategy and duration. Initial, rather optimistic, estimations regarding the probability of treatment discontinuation without increased relapsing risk have now been replaced by guidelines with more strict criteria for selecting candidates for treatment discontinuation.
authors.affiliation: 1st Paediatric Department, Aristotle University, Thessaloniki, Greece. christoforidis@doctors.org.uk
authors.forename: Athanasios
authors.initials: A
authors.lastname: Christoforidis
authors.forename: Christos
authors.initials: C
authors.lastname: Tsakalides
authors.forename: Athanasia
authors.initials: A
authors.lastname: Anastasiou
authors.forename: Antigoni
authors.initials: A
authors.lastname: Pavlaki
authors.forename: Meropi
authors.initials: M
authors.lastname: Dimitriadou
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000077465:Cabergoline; D004873:Ergolines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy / Q000379:methods; D008572:Menarche; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015175:Prolactinoma / Q000188:drug therapy* / Q000473:pathology; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents; D004873:Ergolines; D000077465:Cabergoline