title: Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders.
abstract: The incidence and severity of disease in cows is greatest during the transition period, when immune functions are impaired. Intense lipid mobilization is associated with both metabolic and infectious diseases in the transition cow. Significant increases in plasma nonesterified fatty acids contribute to oxidative stress and uncontrolled inflammatory responses. A dysfunctional inflammatory response is the common link between metabolic and infectious diseases around the time of calving. Intervention strategies that can reduce lipid mobilization may improve inflammatory responses and reduce the economic losses associated with health disorders during the transition period.
authors.affiliation: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 784 Wilson Road, G300 Veterinary Medical Center, East Lansing, MI 48824, USA. sordillo@msu.edu
authors.forename: Lorraine M
authors.initials: LM
authors.lastname: Sordillo
authors.forename: William
authors.initials: W
authors.lastname: Raphael
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000662:veterinary*; D007774:Lactation / Q000378:metabolism / Q000502:physiology*; D008053:Lipid Mobilization / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology; D011247:Pregnancy; D011644:Puerperal Disorders / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D005230:Fatty Acids, Nonesterified