title: Increased risk of coronary heart disease among individuals reporting adverse impact of stress on their health: the Whitehall II prospective cohort study.
abstract: OBJECTIVE
  Response to stress can vary greatly between individuals. However, it remains unknown whether perceived impact of stress on health is associated with adverse health outcomes. We examined whether individuals who report that stress adversely affects their health are at increased risk of coronary heart disease (CHD) compared with those who report that stress has no adverse health impact.
  
  
  RESULTS
  Analyses are based on 7268 men and women (mean age: 49.5 years, interquartile range: 11 years) from the British Whitehall II cohort study. Over 18 years of follow-up, there were 352 coronary deaths or first non-fatal myocardial infarction (MI) events. After adjustment for sociodemographic characteristics, participants who reported at baseline that stress has affected their health 'a lot or extremely' had a 2.12 times higher (95% CI 1.52-2.98) risk of coronary death or incident non-fatal MI when compared with those who reported no effect of stress on their health. This association was attenuated but remained statistically significant after adjustment for biological, behavioural, and other psychological risk factors including perceived stress levels, and measures of social support; fully adjusted hazard ratio: 1.49 (95% CI 1.01-2.22).
  
  
  CONCLUSIONS
  In this prospective cohort study, the perception that stress affects health, different from perceived stress levels, was associated with an increased risk of coronary heart disease. Randomized controlled trials are needed to determine whether disease risk can be reduced by increasing clinical attention to those who complain that stress greatly affects their health.
authors.affiliation: Unit 1018, Epidemiology of occupational and social determinants of health Team, INSERM, Centre for Research in Epidemiology and Population Health, F-94807 Villejuif, France.
authors.forename: Hermann
authors.initials: H
authors.lastname: Nabi
authors.forename: Mika
authors.initials: M
authors.lastname: Kivimäki
authors.forename: G David
authors.initials: GD
authors.lastname: Batty
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Shipley
authors.forename: Annie
authors.initials: A
authors.lastname: Britton
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Brunner
authors.forename: Jussi
authors.initials: J
authors.lastname: Vahtera
authors.forename: Cédric
authors.initials: C
authors.lastname: Lemogne
authors.forename: Alexis
authors.initials: A
authors.lastname: Elbaz
authors.forename: Archana
authors.initials: A
authors.lastname: Singh-Manoux
mesh_terms: D001294:Attitude to Health; D003327:Coronary Disease / Q000401:mortality / Q000523:psychology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008131:London / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010465:Perception; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D013315:Stress, Psychological / Q000150:complications* / Q000401:mortality
keywords: Coronary heart disease; Epidemiology; Prospective studies; Stress