title: PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers.
abstract: A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Li
authors.forename: Zhishen
authors.initials: Z
authors.lastname: Ge
authors.forename: Shiyong
authors.initials: S
authors.lastname: Liu
mesh_terms: D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000737:chemistry / Q000378:metabolism*; D020782:Matrix Metalloproteinases / Q000737:chemistry / Q000378:metabolism*; D008823:Micelles; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008823:Micelles; D010455:Peptides; D011092:Polyethylene Glycols; D020782:Matrix Metalloproteinases