title: Strategies for the use of mechanical ventilation in the neurologic intensive care unit.
abstract: Mechanical ventilation in neurologically injured patients presents unique challenges. Patients with acute neurologic injuries may require mechanical ventilation for reasons beyond respiratory failure. There is also a subset of pulmonary pathologic abnormality directly associated with neurologic injuries. Balancing the need to maintain brain oxygenation, cerebral perfusion, and control of intracranial pressure can be in conflict with concurrent ventilator strategies aimed at lung protection. Weaning and liberation from mechanical ventilation also require special considerations. These issues are examined in the ventilator management of the neurologically injured patient.
authors.affiliation: Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: Wan-Tsu W
authors.initials: WT
authors.lastname: Chang
authors.forename: Paul A
authors.initials: PA
authors.lastname: Nyquist
mesh_terms: D001929:Brain Edema / Q000601:surgery; D006801:Humans; D007362:Intensive Care Units; D007427:Intracranial Pressure / Q000502:physiology; D010100:Oxygen / Q000378:metabolism; D012121:Respiration, Artificial / Q000379:methods*; D020196:Trauma, Nervous System / Q000378:metabolism / Q000628:therapy*
chemical_list: D010100:Oxygen