title: Imipenem versus piperacillin/tazobactam for empiric treatment of neutropenic fever in adults.
abstract: Australian guidelines for neutropenic fever recommend piperacillin/tazobactam (PIP-TAZ) or cefepime for first-line empiric treatment of neutropenic fever. We compared outcomes among haematology patients before and after changing our first-line neutropenic fever treatment from imipenem to PIP-TAZ. Forty-five patients received imipenem and 60 PIP-TAZ. Despite a higher rate of antibiotic modification in the PIP-TAZ cohort, treatment success and time to defervescence were similar, with a trend towards fewer Clostridium difficile infections in the PIP-TAZ cohort.
authors.affiliation: Wellington Blood and Cancer Centre, Capital and Coast District Health Board, Wellington, New Zealand.
authors.forename: A
authors.initials: A
authors.lastname: Roohullah
authors.forename: A
authors.initials: A
authors.lastname: Moniwa
authors.forename: C
authors.initials: C
authors.lastname: Wood
authors.forename: M
authors.initials: M
authors.lastname: Humble
authors.forename: M
authors.initials: M
authors.lastname: Balm
authors.forename: J
authors.initials: J
authors.lastname: Carter
authors.forename: R
authors.initials: R
authors.lastname: Weinkove
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015331:Cohort Studies; D057915:Drug Substitution / Q000379:methods*; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000175:diagnosis / Q000188:drug therapy*; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000008:administration & dosage; D000077725:Piperacillin, Tazobactam Drug Combination; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D015378:Imipenem; D010397:Penicillanic Acid; D010878:Piperacillin
keywords: imipenem; neutropenia; piperacillin; sepsis; tazobactam