title: Correlation of contrast-enhanced ultrasound kinetics with prognostic factors in invasive breast cancer.
abstract: OBJECTIVE
  To correlate contrast-enhanced ultrasound (CEUS) kinetic parameters with traditional and molecular prognostic factors in invasive breast cancer.
  
  
  METHODS
  Seventy-five invasive breast cancers were evaluated with contrast harmonic imaging after the injection of a bolus dose of 2.4 ml sulphur hexafluoride microbubble contrast agent. The lognormal function was used for quantitative analysis of kinetic data. These parameters correlated with traditional prognostic factors (tumour size, histological type, tumour grade, axillary lymph node status) and immunohistochemical biomarkers (ER, PR and HER2 status).
  
  
  RESULTS
  Statistically significant correlation was found between time-to-peak and tumour grade (P value  =  0.023), PR status (P value =  0.042) and axillary node status (P value  =  0.025). Wash-out ratio, measured at 21 s was significantly associated with ER status (P value  =  0.042) and PR status (P value  =  0.026).
  
  
  CONCLUSIONS
  Invasive breast carcinomas exhibiting earlier peak enhancement and faster elimination of microbubble contrast agent at CEUS are found to be associated with established predictors of poor prognosis.
authors.affiliation: Department of Radiology, Faculty of Medicine, University of Szeged, 6725, Szeged, Semmelweis u. 6., Hungary, raeszabb@gmail.com.
authors.forename: Botond K
authors.initials: BK
authors.lastname: Szabó
authors.forename: Ariel
authors.initials: A
authors.lastname: Saracco
authors.forename: Ervin
authors.initials: E
authors.lastname: Tánczos
authors.forename: Peter
authors.initials: P
authors.lastname: Aspelin
authors.forename: Karin
authors.initials: K
authors.lastname: Leifland
authors.forename: Brigitte
authors.initials: B
authors.lastname: Wilczek
authors.forename: Rimma
authors.initials: R
authors.lastname: Axelsson
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001365:Axilla / Q000000981:diagnostic imaging; D001706:Biopsy; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D044584:Carcinoma, Ductal / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007700:Kinetics; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D008954:Models, Biological; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D011379:Prognosis; D021701:Sentinel Lymph Node Biopsy; D013459:Sulfur Hexafluoride; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D013459:Sulfur Hexafluoride