title: Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics.
abstract: Esophageal cancer is aggressive and has poor prognosis. Esophageal squamous cell carcinoma (ESCC) is histologically the most prevalent type of esophageal cancer and ranked as the sixth leading cause of cancer death worldwide. In recent years, cancer has been widely regarded as genetic disease, as well as epigenetic abnormalities including DNA methylation, histone deacetylation, chromatin remodeling, gene imprinting and noncoding RNA regulation. In this review, we will provide a general overview of genes, proteins and microRNAs that are involved in the development of ESCC, which aims to enhance our understanding of molecular mechanisms implicated in ESCC development and progression.
authors.affiliation: Departments of Clinical Oncology, The University of Hong Kong, Hong Kong; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: D L
authors.initials: DL
authors.lastname: Kwong
authors.forename: T
authors.initials: T
authors.lastname: Cao
authors.forename: Q
authors.initials: Q
authors.lastname: Hu
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Ming
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Fu
authors.forename: X
authors.initials: X
authors.lastname: Guan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D044127:Epigenesis, Genetic; D004938:Esophageal Neoplasms / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D055106:Genome-Wide Association Study; D006801:Humans; D035683:MicroRNAs; D040901:Proteomics
chemical_list: D035683:MicroRNAs
keywords: MicroRNA; esophageal cancer; proteomics; transcriptomics