title: Photodynamic therapy leads to complete remission of tongue tumors and inhibits metastases to regional lymph nodes.
abstract: In patients diagnosed with oral cancer, the most important prognostic indicator for patient survival after primary treatment is metastasis to the cervical lymph nodes or distal sites. Therefore, we evaluated the utility of photodynamic therapy (PDT) mediated by aluminum-chloride-phthalocyanine entrapped in liposomes for the prevention of metastasis to regional cervical lymph nodes in the Erhlich tongue cancer model. The PDT protocol led to complete remission of tongue tumours and prevented the occurrence of regional metastasis. The prevention of regional metastasis was confirmed by histopathological and immunohistochemical analyses. In addition, PDT treatment increased the overall survival and reduced weight loss relative to control tumour-bearing mice. Thus, PDT should be clinically evaluated for use in the prevention of cervical lymph node metastasis in patients with oral cancer.
authors.affiliation: Laboratório de Nanobiotecnologia, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília-Campus Universitário Darcy Ribeiro, Brasília-DF 70910-970, Brasil.
authors.forename: Leandro Santos
authors.initials: LS
authors.lastname: Bicalho
authors.forename: João Paulo Figueiró
authors.initials: JP
authors.lastname: Longo
authors.forename: Claudio Eduardo Oliveira
authors.initials: CE
authors.lastname: Cavalcanti
authors.forename: Andreza Ribeiro
authors.initials: AR
authors.lastname: Simioni
authors.forename: Anamélia Lorenzetti
authors.initials: AL
authors.lastname: Bocca
authors.forename: Maria de Fátima Menezes de Almeida
authors.initials: Mde F
authors.lastname: Santos
authors.forename: Antônio Cláudio
authors.initials: AC
authors.lastname: Tedesco
authors.forename: Ricardo Bentes
authors.initials: RB
authors.lastname: Azevedo
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology*; D004353:Drug Evaluation, Preclinical; D007211:Indoles / Q000627:therapeutic use*; D008198:Lymph Nodes / Q000187:drug effects* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010778:Photochemotherapy / Q000379:methods; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D012074:Remission Induction; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C044797:chloroaluminum phthalocyanine