title: Dysmegakaryocytopoiesis and maintaining platelet count in patients with plasma cell neoplasm.
abstract: BACKGROUND
  Dysmegakaryocytopoiesis in patients with the plasma cell neoplasm (PCN) is rarely discussed in the literature. The puzzling phenomenon, which PCN patients maintaining normal platelet count even when the marrow is mostly replaced by plasma cells, is hardly explored.
  
  
  OBJECTIVE
  This study was aimed to determine the frequency of dysmegakaryocytopoiesis in PCN and the relationships between bone marrow (BM) plasma cell percentage, plasma cell immunomarkers, the severity of dysmegakaryocytopoiesis, and peripheral blood platelet count in PCN.
  
  
  METHODS
  We randomly selected 16 cases of PCN, among which 4 were with monoclonal gammopathy of undetermined significance and 12 were with plasma cell myeloma.
  
  
  RESULTS
  OUR STUDY SHOWED THAT: (1) Dysmegakaryocytopoiesis was present in all the selected cases of PCN and its severity was not correlated with the percentage of the plasma cells in BM; (2) almost all patients maintained normal platelet count even when BM was mostly replaced by plasma cells; (3) immunomarkers of the neoplastic plasma cells were not associated with dysmegakaryocytopoiesis or maintaining of platelet count. The possible mechanisms behind dysmegakaryocytopoiesis and maintaining of platelet count were also discussed.
  
  
  CONCLUSIONS
  Despite the universal presence of dysmegakaryocytopoiesis in PCN, the platelet count is maintained at normal range.
authors.affiliation: Department of Pathology, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, NY, USA.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Mair
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Donghong
authors.initials: D
authors.lastname: Cai
keywords: Dysmegakaryocytopoiesis; Peripheral blood platelet count; Plasma cell neoplasm