title: Enhanced Intestinal Motility during Oral Glucose Tolerance Test after Laparoscopic Sleeve Gastrectomy: Preliminary Results Using Cine Magnetic Resonance Imaging.
abstract: Enhanced secretion of glucagon-like peptide-1 (GLP-1) has been suggested as a possible mechanism underlying the improvement in type 2 diabetes mellitus (T2DM) after laparoscopic sleeve gastrectomy (LSG). However, the reason for enhanced GLP-1 secretion during glucose challenge after LSG remains unclear because LSG does not include intestinal bypass. In this study, we focused on the effects of LSG on GLP-1 secretion and intestinal motility during the oral glucose tolerance test (OGTT) using cine magnetic resonance imaging (MRI) before and 3 months after LSG.
  
  
  
  LSG was performed in 12 obese patients with a body mass index >35 kg/m(2). Six patients had T2DM. OGTT was performed before and 3 months after the surgery. Body weight, hemoglobin A1c (HbA1c), and GLP-1 levels during OGTT were examined, and intestinal motility during OGTT was assessed using cine MRI.
  
  
  
  Body weight was significantly decreased after surgery in all the cases. HbA1c was markedly decreased in all the diabetic subjects. In all cases, GLP-1 secretion during OGTT was enhanced and cine MRI showed markedly increased intestinal motility at 15 and 30 min during OGTT after LSG.
  
  
  
  LSG leads to accelerated intestinal motility and reduced intestinal transit time, which may be involved in the mechanism underlying enhanced GLP-1 secretion during OGTT after LSG.
authors.affiliation: Department of Surgery, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan.
authors.forename: Vo Nguyen
authors.initials: VN
authors.lastname: Trung
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Furukawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Murata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Yoko
authors.initials: Y
authors.lastname: Murakami
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Sato
authors.forename: Hideji
authors.initials: H
authors.lastname: Otani
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ugi
authors.forename: Katsutaro
authors.initials: K
authors.lastname: Morino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maegawa
authors.forename: Tohru
authors.initials: T
authors.lastname: Tani
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000601:surgery*; D005743:Gastrectomy / Q000379:methods*; D005769:Gastrointestinal Motility; D005951:Glucose Tolerance Test; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*