title: [Mechanism of hepatoprotective action of methionine and composition "Metovitan" against a background of antituberculosis drug administration to rats].
abstract: Oral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state. Experimental composition "Metovitan" given with anti-TB drugs provided a correction of these abnormalities, that is evidenced by modulation of the level of CYP3A2, CYP2C23, CYP2E1 gene expression and antioxidant activity, inhibition of lipid peroxidation. "Metovitan" normalizes the enzymatic activity and content of total billirubin in the blood serum, shows high hepatoprotective properties, exceeding the efficiency of methionine.
authors.forename: S I
authors.initials: SI
authors.lastname: Anisimova
authors.forename: H V
authors.initials: HV
authors.lastname: Donchenko
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Parkhomenko
authors.forename: V M
authors.initials: VM
authors.lastname: Kovalenko
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D001711:Biotransformation; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000517:prevention & control*; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004338:Drug Combinations; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008715:Methionine / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; C000717351:Cyp2c23 protein, rat; D004338:Drug Combinations; D003577:Cytochrome P-450 Enzyme System; D008715:Methionine; D000090762:Cytochrome P-450 CYP2J2