title: Clostridium difficile infection associated with antituberculous agents in a patient with tuberculous pericarditis.
abstract: Clostridium difficile can cause pseudomembranous colitis (PMC). Antimicrobial agent exposure is a risk factor for Clostridium difficile-associated disease, whereas the use of antituberculous (anti-TB) agents is not. We herein report a case of PMC-associated with antituberculous therapy. A 63-year-old woman with tuberculous pericarditis treated with anti-TB agents was admitted for abdominal pain and diarrhea. On colonoscopy, mucoid exudate and yellowish plaque lesions were observed. The anti-TB agents were discontinued, and the patient was treated with metronidazole and clostridium butyricum. Her symptoms were relieved and did not recur when the anti-TB agents were restarted. In this report, we review the literature and discuss the pathogenesis, clinical manifestations, diagnosis and treatment of this case.
authors.affiliation: Department of Geriatric Medicine, East Hospital, Tongji University School of Medicine, China.
authors.forename: Yi-Xuan
authors.initials: YX
authors.lastname: Sun
authors.forename: Yin-Tao
authors.initials: YT
authors.lastname: Zhao
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Teng
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Ge
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Li
authors.initials: L
authors.lastname: Shao
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects*; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis*; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010495:Pericarditis, Tuberculous / Q000175:diagnosis* / Q000209:etiology
chemical_list: D000995:Antitubercular Agents