title: Lack of relationships between FGF19 staining pattern, lymph node metastasis and locally invasive characteristics of the tumor in colorectal cancers.
abstract: BACKGROUND
  Colorectal cancers are in the top of the cancer-related causes of death in the world and lymph node metastasis is accepted as the primary prognostic factor. In this study, correlations of FGF19 staining pattern with local invasion and lymph node metastasis in a series of colorectal cancers were investigated.
  
  
  METHODS
  This studyincluded 81 colorectal cancer patients who underwent surgery in our hospital with no evidence of preoperative radiological distant metastasis. Routine pathological examination of the resection material was performed in order to identify vascular, perineural and serosal infiltration, regional lymph node metastasis and the degree of differentiation. Tumor tissue samples were stained with an immunohistochemistry method for FGF 19 evaluation and the staining pattern was statistically compared with the above mentioned characteristics of the tumors.
  
  
  RESULTS
  The patient population consisted of 47 females and 34 males with a median age of 70 years. In 40 patients regional lymph nodes were positive and 51%, 32% and 38% had serosal, perineural and vascular invasion. While 64 cases were moderately-differentiated, 11 cases were well-differentiated and 6 poorly- differentiated, there was no association with FGF 19 staining, including intensity.
  
  
  CONCLUSIONS
  No evidence of significant statistically correlation was found between FGF 19 staining pattern and serosal, perineural, vascular invasion, lymph node involvement and degree of differentiation.
authors.affiliation: GastroenterologyDepartment, Baskent University Faculty of Medicine, Ankara, Turkey. hakan75unal@yahoo.com
authors.forename: Hakan Umit
authors.initials: HU
authors.lastname: Unal
authors.forename: Ebru
authors.initials: E
authors.lastname: Demiralay
authors.forename: Merih
authors.initials: M
authors.lastname: Tepeoğlu
authors.forename: Cihan
authors.initials: C
authors.lastname: Fidan
authors.forename: Saadettin
authors.initials: S
authors.lastname: Kilickap
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D013194:Staining and Labeling; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C117476:FGF19 protein, human; D005346:Fibroblast Growth Factors