title: GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals.
abstract: GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16- natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.
authors.affiliation: Research and Medical Services, Iowa City VA Medical Center, Iowa City, IA 52242, USA. jack-stapleton@uiowa.edu
authors.forename: Jack T
authors.initials: JT
authors.lastname: Stapleton
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Martinson
authors.forename: Donna
authors.initials: D
authors.lastname: Klinzman
authors.forename: Jinhua
authors.initials: J
authors.lastname: Xiang
authors.forename: Seema N
authors.initials: SN
authors.lastname: Desai
authors.forename: Alan
authors.initials: A
authors.lastname: Landay
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D019002:CD56 Antigen / Q000032:analysis; D018178:Flaviviridae Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D029407:GB virus C / Q000276:immunology*; D058851:GPI-Linked Proteins / Q000032:analysis; D015658:HIV Infections / Q000150:complications*; D006525:Hepatitis, Viral, Human / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D006801:Humans; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D017452:Receptors, IgG / Q000032:analysis
chemical_list: D019002:CD56 Antigen; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; C522918:NCAM1 protein, human; D017452:Receptors, IgG