title: Increased levels of macrophage migration inhibitory factor in patients with familial mediterranean Fever.
abstract: OBJECTIVE
  To determine the level of macrophage migration inhibitory factor (MIF), its relationship with Mediterranean fever (MEFV) gene mutations and oxidative stress in familial Mediterranean fever (FMF).
  
  
  METHODS
  Fifty one unrelated attack free FMF patients (24 M and 27 F, 32.8±8.7 years) and 30 healthy controls (16 M and 14 F, 32.7±7 years) were included in the study. Serum MIF, total oxidant status (TOS) and total anti-oxidant status (TAS) were studied.
  
  
  RESULTS
  Age, sex distribution, anthropometrical indices, smoking status, serum lipids and TAS concentrations were similar between the patients and controls. However; erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), MIF, and TOS were significantly higher in the patients' group compared with healthy subjects. MIF, TOS and TAS levels were not different between patients with or without M694V mutations.
  
  
  CONCLUSIONS
  We found increased concentrations of MIF in patients with FMF. Increased MIF levels were significantly correlated with oxidative stress and in regression analysis MIF concentrations were independent from the inflammatory activity as assessed by ESR and CRP. M694V mutations seem no effect on MIF and oxidative stress.
authors.affiliation: Dokuz Eylul University School of Medicine, Department of Internal Medicine, Izmir, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Savran
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.forename: Didem Leyla
authors.initials: DL
authors.lastname: Kozaci
authors.forename: Necati
authors.initials: N
authors.lastname: Gunay
authors.forename: Fatos
authors.initials: F
authors.lastname: Onen
authors.forename: Servet
authors.initials: S
authors.lastname: Akar
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D010505:Familial Mediterranean Fever / Q000097:blood*; D005260:Female; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood* / Q000235:genetics; D008297:Male; D009154:Mutation
chemical_list: D008263:Macrophage Migration-Inhibitory Factors
keywords: Familial Mediterranean fever; Inflammation.; Macrophage migration inhibitory factors; Oxidative stress