title: Finding the shape-shifter genes.
abstract: Cell morphological plasticity is controlled by intracellular signalling pathways. By combining large-scale imaging with quantitative analysis, an RNA interference (RNAi) screen in Drosophila melanogaster haemocytes reveals that most targeted genes regulate transitions between discrete shapes. Loss of gene function changes shape frequencies or reduces diversity, rather than producing new morphologies.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Olson
mesh_terms: D000818:Animals; D048430:Cell Shape; D004331:Drosophila melanogaster / Q000378:metabolism*; D016147:Genes, Tumor Suppressor; D005820:Genetic Testing; D006801:Humans; D008545:Melanoma / Q000556:secondary*; D034622:RNA Interference