title: Successful treatment of a patient with multicentric Castleman's disease who presented with thrombocytopenia, ascites, renal failure and myelofibrosis using tocilizumab, an anti-interleukin-6 receptor antibody.
abstract: We herein describe an unusual case of multicentric Castleman's disease accompanied by thrombocytopenia, ascites, renal failure and myelofibrosis in a Japanese woman. The patient was initially diagnosed as having myelodysplastic syndrome with myelofibrosis. The general condition of the patient deteriorated rapidly; however, treatment with tocilizumab, an anti-interleukin-6 receptor antibody, together with corticosteroids dramatically improved her symptoms. The clinical features of this case were similar to those of three cases previously reported by Takai et al. (Rinsho Ketsueki, 2010, 51:320-5), which were determined to be thrombocytopenia, anasarca, fever, reticulin myelofibrosis and organomegaly (TAFRO) syndrome, a possibly distinct clinical entity.
authors.affiliation: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan. hkawabat@kuhp.kyoto-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawabata
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kotani
authors.forename: Yumi
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Kondo
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Katsurada
authors.forename: Hironori
authors.initials: H
authors.lastname: Haga
authors.forename: Norimitsu
authors.initials: N
authors.lastname: Kadowaki
authors.forename: Akifumi
authors.initials: A
authors.lastname: Takaori-Kondo
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001201:Ascites / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D019947:Receptors, Interleukin-6 / Q000037:antagonists & inhibitors*; D051437:Renal Insufficiency / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D019947:Receptors, Interleukin-6; C502936:tocilizumab