title: Autophagy in cellular transformation, survival and communication with the tumor microenvironment.
abstract: Autophagy describes several metabolic pathways, by which cytoplasmic constituents are imported into lysosomes for degradation. These pathways and in particular macroautophagy play an important role during oncogenesis by apparently inhibiting cellular transformation initially, but then ensuring tumor cell survival in established cancers. Furthermore, the conditioning of the tumor microenvironment, including the cross-talk with the immune system, is influenced by autophagy. These multiple facets of autophagy regulation in tumors will be discussed in the series of review articles of this issue of Seminars in Cancer Biology. A comprehensive understanding of this pathway in oncology is needed to efficiently apply autophagy regulating tumor therapies, which are already in use.
authors.affiliation: Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. Electronic address: christian.muenz@uzh.ch.
authors.forename: Christian
authors.initials: C
authors.lastname: Münz
mesh_terms: D001343:Autophagy / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D008247:Lysosomes / Q000473:pathology / Q000502:physiology; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology; D059016:Tumor Microenvironment / Q000502:physiology*