title: [Cardiac natriuretic peptides and hypertension: experimental study].
abstract: The peculiarities of cardiac natriuretic peptide secretion have been investigated during ontogenesis using the hypertonic disease model in ISIAH rat line (with inherited stress induced arterial hypertension). The qualitative and quantitative ultrastructural investigations of right atrium myocardium revealed that the cardiac hormonal synthetic and secretory activities in ISIAH rats are higher as compared with normotensive even-aged rats from control group. Secretory hyperactivity of atrial myocytes in ISIAH rats during early ontogeny precedes the manifestations of hereditary hypertension. Natriuretic peptides present the hypotensive circuit of hemodynamic regulation during the whole ontogeny and the complementary chain in hypertension development.
authors.forename: V F
authors.initials: VF
authors.lastname: Maksimov
authors.forename: I M
authors.initials: IM
authors.lastname: Korostyshevskaia
authors.forename: A L
authors.initials: AL
authors.lastname: Markel'
authors.forename: E E
authors.initials: EE
authors.lastname: Filiushina
authors.forename: G S
authors.initials: GS
authors.lastname: Iakobson
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D005260:Female; D006056:Golgi Apparatus / Q000378:metabolism / Q000648:ultrastructure; D006321:Heart / Q000196:embryology / Q000254:growth & development; D006325:Heart Atria / Q000378:metabolism* / Q000648:ultrastructure*; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009320:Atrial Natriuretic Factor