title: [Influence of acupoint injection with small dose of fentanyl-droperidol mixed liquor on labor analgesia and level of stress hormone in parturient].
abstract: OBJECTIVE
  To observe the clinical effect of acupoint injection with small dose of fentanyl-droperido mixed liquor at different time stages on labor analgesia, and explore its function mechanism.
  
  
  METHODS
  One hundred and fifty cases of full-term primiparas who were intended to take vaginal delivery were randomly divided into 3 groups, 50 cases in each one. The acupoint injection with fentanyl-droperido mixed liquor at different time stages was applied in the group I, where Shenshu (BL 23) was selected in active phase and Ciliao (BL 32) was selected in the 2nd stage of labor. The subcutaneous injection with fentanyl-droperido mixed liquor was adopted in group II. The group III, which was considered as a control group, was treated with subcutaneous injection of 0.9% NaCl at the same time stage as group I and II. The blood pressure, VAS score and level of norepinephrine and adrenaline were observed at different time stages.
  
  
  RESULTS
  Compared before the injection, the blood pressure of group III in the active phase and 2nd stage of labor was significantly increased (P < 0.05), and that in group II and III was obviously higher than that in the group I (P < 0.05). The VAS score of group I in the active phase and 2nd stage of labor was significantly lower than that in the group II and III (P < 0.01). After the injection, the level of NE and E was significantly decreased (P < 0.05), which was lower than that in the group II and III (P < 0.05).
  
  
  CONCLUSIONS
  The acupoint injection with small dose of fentanyl-droperido mixed liquor at different time stages has positive effect on labor analgesia, and it could significantly relieve stress reaction of parturient during the labor. Its mechanism could be related to the reduction of stress hormone in parturient.
authors.affiliation: Department of anesthesiology, Second Affiliated Hospital of Hebei North College, Xuanhua 075100, China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Zhu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yao
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Wu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Yan
authors.forename: Xin-Jing
authors.initials: XJ
authors.lastname: Su
mesh_terms: D015669:Acupuncture Points; D000328:Adult; D016362:Analgesia, Obstetrical; D000700:Analgesics / Q000008:administration & dosage*; D036861:Delivery, Obstetric; D004329:Droperidol / Q000008:administration & dosage*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D048949:Labor Pain / Q000188:drug therapy; D007743:Labor, Obstetric / Q000378:metabolism*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000700:Analgesics; D006728:Hormones; D004329:Droperidol; D005283:Fentanyl