title: Analysis of the changes in the basal cell region of oral lichen planus: An ultrastructural study.
abstract: BACKGROUND
  Oral lichen planus (OLP) affects 0.5-1% of the total world's population. The histological features of oral lichen planus were first described by Dubreuill in 1906. Despite the advent of various techniques, the etiology of lichen planus remains obscure, although many theories for the etiology have been proposed.
  
  
  OBJECTIVE
  By studying OLP electron microscopically, we shall be emphasizing on the cells and its interactions in specific/altered surroundings which would help us in hypothesizing the effects of its specific cell-to-cell interactions.
  
  
  METHODS
  A total of 20 cases of oral lichen planus were selected and categorized into erosive and nonerosive forms based upon clinical pattern and confirmed as lichen planus by histopathological analysis. Tissue specimens thus obtained were cut into two halves and fixed in appropriate fixatives, i.e., neutral buffered formalin for paraffin-embedded hematoxylin and eosin stained sections and 2.5% glutaraldehyde and 2% paraformaldehyde for electron microscopic purpose respectively.
  
  
  RESULTS
  Ultrastructural comparison among the two forms showed significant differences between them. The basal layer showed cytoplasmic processes, intercellular spaces, desmosomes, nuclei, and signs of degeneration. The erosive form showed elongated, narrow or irregular cytoplasmic projections whereas the nonerosive showed short and broad based projections.
  
  
  CONCLUSIONS
  The present study confirms the ultrastructural findings of basal cells in OLP with previous authors findings. Besides this, the categorization of the ultrastructural differences between erosive and nonerosive has raised the question of difference in the probable cellular and molecular mechanism between erosive and nonerosive forms.
authors.affiliation: Department of Oral Pathology, Inderprastha Dental College and Hospital, Sahibabad, Ghaziabad, India.
authors.forename: Mayura
authors.initials: M
authors.lastname: Paul
authors.forename: Devi Charan
authors.initials: DC
authors.lastname: Shetty
keywords: Basal cells; lichen planus; ultrastructure