title: Targeted antigen delivery to DEC-205⁺ dendritic cells for tolerogenic vaccination.
abstract: Dendritic cells (DCs) and Foxp3-expressing CD4⁺ regulatory T (Treg) cells play non-redundant roles in the maintenance of peripheral tolerance to self-antigens, thereby preventing fatal autoimmunity. A common hallmark of intra- and extra-thymic Treg cell lineage commitment is the induction of Foxp3 expression as a consequence of appropriate T cell receptor engagement with MHC class II:agonist ligand. It has now become increasingly clear that agonist ligand presentation by immature DCs in the steady state induces T cell tolerance by both recessive and dominant mechanisms, rather than promoting productive T helper cell responses. In this context, the ability of steady-state DCs to promote the extrathymic conversion of initially naïve CD4⁺Foxp3⁻ T cells into Foxp3⁺ Treg cells is of particular interest as it provides novel perspectives to enhance antigen-specific Treg cell function in clinical settings of unwanted immunity, such as β-cell autoimmunity.
authors.affiliation: Immunotolerance in Regeneration, Center for Regenerative Therapies Dresden, Dresden, Germany.
authors.forename: Cathleen
authors.initials: C
authors.lastname: Petzold
authors.forename: Sonja
authors.initials: S
authors.lastname: Schallenberg
authors.forename: Joel N H
authors.initials: JN
authors.lastname: Stern
authors.forename: Karsten
authors.initials: K
authors.lastname: Kretschmer
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology*; D015551:Autoimmunity; D003713:Dendritic Cells / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000235:genetics* / Q000276:immunology*; D018390:Gene Targeting; D006801:Humans; D007108:Immune Tolerance; D050417:Insulin-Secreting Cells / Q000276:immunology; D037181:Lectins, C-Type / Q000235:genetics / Q000276:immunology*; D015778:Minor Histocompatibility Antigens; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014611:Vaccination
chemical_list: D015703:Antigens, CD; C093569:DEC-205 receptor; D051858:Forkhead Transcription Factors; D037181:Lectins, C-Type; D015778:Minor Histocompatibility Antigens; D011956:Receptors, Cell Surface