title: Effect of bariatric surgery on bone mineral density: comparison of gastric bypass and sleeve gastrectomy.
abstract: The aim of our study was to compare bone mineral density (BMD) a year after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in age- and body mass index-matched women. In 33 morbidly obese women undergoing RYGB and 33 undergoing SG, plasma determinations of calcium, parathyroid hormone (PTH), 25-hydroxyvitamin D (25(OH) D3), and insulin-like growth factor-I (IGF-I) were made prior to and at 12 months after surgery. Dual-energy X-ray absorptiometry was performed in all patients 1 year after surgery. BMD at the femoral neck and the lumbar spine 1 year after surgery was similar in women undergoing RYGB and SG (1.01 ± 0.116 vs. 1.01 ± 0.122 g/cm(2), p = 0.993; 1.05 ± 0.116 vs. 1.08 ± 0.123 g/cm(2), p = 0.384). The percentage of patients with osteopenia and osteoporosis was not different between groups. In the linear regression analysis, age (β = -0.628, p = 0.034) and lean mass 12 months after surgery (β = 0.424, p = 0.021) were found to be the main determinants of femoral neck BMD. Age (β = -0.765, p = 0.025), menopause (β = -0.898, p = 0.033), and lean mass (β = 0.615, p = 0.023) were determinants of BMD at the lumbar spine. No influence was found between low bone mass and type of surgery, plasma PTH, 25(OH) D3, or IGF-I. The effect of RYGB and SG on BMD was comparable a year after surgery. Menopausal women were at a higher risk of having low bone mass, but the presence of osteoporosis was uncommon.
authors.affiliation: Endocrinology Service, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Bellvitge University Hospital-IDIBELL, C/ Rambla Just Oliveras, Nº 64, 3º 2ª escalera A, 08901, L'Hospitalet de Llobregat, Barcelona, Spain, nuriavilarrasa@yahoo.es.
authors.forename: Nuria
authors.initials: N
authors.lastname: Vilarrasa
authors.forename: Amador G Ruiz
authors.initials: AG
authors.lastname: de Gordejuela
authors.forename: Carmen
authors.initials: C
authors.lastname: Gómez-Vaquero
authors.forename: Jordi
authors.initials: J
authors.lastname: Pujol
authors.forename: Iñaki
authors.initials: I
authors.lastname: Elio
authors.forename: Patricia
authors.initials: P
authors.lastname: San José
authors.forename: Silvia
authors.initials: S
authors.lastname: Toro
authors.forename: Anna
authors.initials: A
authors.lastname: Casajoana
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Gómez
mesh_terms: D015502:Absorptiometry, Photon; D015992:Body Mass Index; D015519:Bone Density; D002118:Calcium / Q000378:metabolism; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects; D015390:Gastric Bypass / Q000009:adverse effects; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008159:Lumbar Vertebrae / Q000378:metabolism*; D008286:Malabsorption Syndromes / Q000209:etiology*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism / Q000601:surgery*; D010281:Parathyroid Hormone / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism; D015431:Weight Loss
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D007334:Insulin-Like Growth Factor I; C104450:25-hydroxyvitamin D; D002118:Calcium