title: Diversification of animal venom peptides-were jellyfish amongst the first combinatorial chemists?
abstract: An ocean of data: Huge numbers of protein toxins are found in animal venoms. This diversity is widely believed to have arisen by gene duplication events. However, recent data now challenges this tradition view. Here we highlight how jellyfish could hold the key to unravelling toxin diversification, with a view towards future combinatorial biosynthesis of toxin libraries.
authors.affiliation: Department of Biochemical Engineering, Faculty of Food Technology & Biotechnology, University of Zagreb, Croatia.
authors.forename: Antonio
authors.initials: A
authors.lastname: Starcevic
authors.forename: Paul F
authors.initials: PF
authors.lastname: Long
mesh_terms: D000818:Animals; D060326:Chemistry Techniques, Synthetic; D003064:Cnidarian Venoms / Q000737:chemistry* / Q000235:genetics; D019143:Evolution, Molecular; D020440:Gene Duplication; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D037401:Scyphozoa / Q000737:chemistry* / Q000145:classification
chemical_list: D003064:Cnidarian Venoms; D010455:Peptides
keywords: Cnidaria; drug design; molecular evolution; toxins; venoms