title: Evaluation of the Oxford Classification of IgA nephropathy: a systematic review and meta-analysis.
abstract: BACKGROUND
  The Oxford Classification of the pathology of immunoglobulin A (IgA) nephropathy, developed in 2009, is highly predictive of renal prognosis. It has been validated in different populations, but the results remain inconsistent.
  
  
  METHODS
  Systematic review and meta-analysis.
  
  
  METHODS
  Patients with biopsy-proven primary IgA nephropathy.
  
  
  METHODS
  Studies assessing the Oxford Classification of IgA nephropathy published between January 2009 and December 2012 were included following systematic searching of the MEDLINE and EMBASE databases.
  
  
  METHODS
  4 pathologic lesions of the Oxford Classification: mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T).
  
  
  RESULTS
  Kidney failure defined as doubled serum creatinine level, 50% decline in estimated glomerular filtration rate, or end-stage kidney disease.
  
  
  RESULTS
  16 retrospective cohort studies with 3,893 patients and 570 kidney failure events were included. In a multivariate model, HRs for kidney failure were 0.6 (95% CI, 0.5-0.8; P < 0.001), 1.8 (95% CI, 1.4-2.4; P < 0.001), and 3.2 (95% CI, 1.8-5.6; P < 0.001) for scores of M0 (mesangial hypercellularity score ≤0.5), S1 (presence of segmental glomerulosclerosis), and T1/2 (>25% tubular atrophy/interstitial fibrosis), respectively, without evidence of heterogeneity. Pooled results showed that E lesions were not associated with kidney failure (HR, 1.4; 95% CI, 0.9-2.0; P = 0.1), with evidence of heterogeneity (I(2) = 54.1%; P = 0.01). Crescent (C) lesions were associated with kidney failure (HR, 2.3; 95% CI, 1.6-3.4; P < 0.001), with no evidence of heterogeneity (I(2) = 14.7%; P = 0.3).
  
  
  CONCLUSIONS
  All studies were retrospective. This was not an individual-patient-data meta-analysis.
  
  
  CONCLUSIONS
  This study suggests that M, S, T, and C lesions, but not E lesions, are associated strongly with progression to kidney failure and thus should be included in the Oxford Classification system.
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Lv
authors.forename: Sufang
authors.initials: S
authors.lastname: Shi
authors.forename: Damin
authors.initials: D
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Stéphan
authors.initials: S
authors.lastname: Troyanov
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Cattran
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
mesh_terms: D001706:Biopsy; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate / Q000502:physiology; D005922:Glomerulonephritis, IGA / Q000145:classification* / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology
chemical_list: D003404:Creatinine
keywords: Immunoglobulin A (IgA) nephropathy; Oxford Classification; meta-analysis