title: [Comparing effectivity of VAC therapy for treatment of infections following arthroplasty or soft-tissue surgery].
abstract: BACKGROUND
  Although vacuum-assisted wound closure (VAC) has been developed into a standard technique in septic surgery, reliable data about the efficacy of the treatment are still lacking.
  
  
  METHODS
  Postoperative infections after arthroplasty or soft-tissue surgery were identified using a prospective database for complications (Critical Incidence Reporting System) which was retrospectively supplemented with items for evaluation of VAC therapy. Eradication success of infection was analysed considering epidemiological parameters, course of treatment, and characteristics of causing bacterial strains. Furthermore, serological C-reactive protein (CRP) concentrations were evaluated for diagnostic and prognostic reliability.
  
  
  RESULTS
  92 patients with an average age of 60 ± 4 years were included in the study. Patients with soft tissue infections (STI, n = 53) were statistically significant younger compared to patients with infections following arthroplasty (AI, n = 39) (53 ± 6 vs. 70 ± 4 years; p < 0.001), but the probability for eradication success was not dependent on age. Mortality was 9-fold higher in the AI group (p < 0.01). Patients with infected endoprostheses were longer treated on intensive care units (6.1 ± 8.4 vs. 3.5 ± 6.5 days; p < 0.01), but there was no statistically significant association to eradication success. Probability for eradication of infection was with 81 % statistically significant higher in the STI group compared to 38 % in the AI group (p < 0.001). Early infections in the AI group were associated with a better healing success when compared to chronic infections (p < 0.05). The same correlation could be shown for the removal of implant (p < 0.0001). Aerobic fermenting bacteria were less effectively eradicated than anaerobic germs following soft-tissue infections (p < 0.01). In cases of osteomyelitis following soft-tissue infection, the probability for eradication of infection was impaired (p < 0.001). Kind and quality of final wound closure in the STI group were statistically significantly associated with eradication success (p < 0.001). There was no critical value concerning the number of revisions until healing of infection was reached. CRP values were higher in the AI group and associated with the prognosis (p < 0.05).
  
  
  CONCLUSIONS
  Probability of eradication success using VAC therapy is higher after soft-tissue infections compared to infections following arthroplasty. Accordingly, mortality is higher in this group. Chronic courses have worse chances for healing in both groups. For serological CRP values a prognostic relevance could be shown.
authors.affiliation: Department für Orthopädie und Traumatologie, Klinikum der Albert-Ludwigs-Universität Freiburg. hagen.schmal@uniklinik-freiburg.de
authors.forename: H
authors.initials: H
authors.lastname: Schmal
authors.forename: M
authors.initials: M
authors.lastname: Oberst
authors.forename: S
authors.initials: S
authors.lastname: Hansen
authors.forename: J
authors.initials: J
authors.lastname: Six-Merker
authors.forename: N P
authors.initials: NP
authors.lastname: Südkamp
authors.forename: K
authors.initials: K
authors.lastname: Izadpanah
mesh_terms: D000368:Aged; D001178:Arthroplasty / Q000401:mortality*; D001424:Bacterial Infections / Q000401:mortality* / Q000601:surgery*; D015984:Causality; D003131:Combined Modality Therapy; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000401:mortality*; D015995:Prevalence; D016459:Prosthesis-Related Infections / Q000401:mortality* / Q000517:prevention & control; D012189:Retrospective Studies; D012307:Risk Factors; D018461:Soft Tissue Infections / Q000401:mortality* / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome