title: [Role of G protein-coupled receptor 17 in central nervous system injury].
abstract: G-protein-coupled receptor 17 (GPR17), an originally orphan receptor, was identified as a new uracil nucleotides/cysteinyl leukotriene receptor. However, whether GPR17 is really classified as a leukotriene receptor is a matter deserving further investigation. GPR17 is involved in many physiological and pathological processes including brain injury, spinal cord injury, and oligodendrocyte differentiation. GPR17 may become a new therapeutic target in these diseases. In this article, the research progress on the pharmacology and pathophysiological roles of GPR17 is reviewed.
authors.affiliation: Key Laboratory of Medical Neurobiology of Ministry of Health, Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Erqing
authors.initials: E
authors.lastname: Wei
authors.forename: Yunbi
authors.initials: Y
authors.lastname: Lu
mesh_terms: D002490:Central Nervous System / Q000293:injuries* / Q000503:physiopathology; D006801:Humans; D055495:Neurogenesis / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism / Q000502:physiology*
chemical_list: C121670:GPR17 protein, human; D043562:Receptors, G-Protein-Coupled