title: Utilizing TH9 cells as a novel therapeutic strategy for malignancies.
abstract: TH9 cells join the ever-growing list of CD4+T helper subsets and primarily mediate anti-parasite immune responses. We have recently demonstrated that tumor-specific TH9 cells induce a CCL20-CCR6-dependent regulation of DCs while stimulating CD8+T cell-mediated antitumor immunity. These findings offer a novel immunotherapeutic strategy against cancer.
authors.affiliation: Department of Lymphoma/Myeloma; Division of Cancer Medicine; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center; Houston, TX USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Lu
authors.forename: Qing
authors.initials: Q
authors.lastname: Yi
keywords: Ccl20; DCs; TCLs; Th9 cell; melanoma