title: COX2 regulation of breast cancer bone metastasis.
abstract: High expression levels of cyclooxygenase 2 expression and infiltration by regulatory T cells (Tregs) are often associated with tumor progression. We have recently reported a prostaglandin E2(PGE2)-dependent recruitment of Tregs to the tumor, suggesting that targeting specific PGE2receptors may constitute a valuable approach to ablate the immuno-editing that occurs along with disease progression.
authors.affiliation: Departments of Molecular Pharmacology and Biological Chemistry; Northwestern University Feinberg School of Medicine; Chicago, IL USA ; Robert H. Lurie Comprehensive Cancer Center; Northwestern University Feinberg School of Medicine; Chicago, IL USA.
authors.forename: John
authors.initials: J
authors.lastname: Karavitis
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
keywords: EP2; EP4; immunosuppression; immunotherapy; mammary tumor; regulatory T cell