title: Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men.
abstract: OBJECTIVE
  To investigate the effects of short-term, reduced-volume sprint interval training (SIT) compared to traditional exercise recommendations (TER) in sedentary obese men.
  
  
  METHODS
  Sixteen subjects [37.8 ± 5.8 years; body mass index (BMI) 32.8 ± 4.7 kg/m(2)] were randomly allocated to 2 weeks of either SIT (6 sessions of 8-12 × 10 s sprints) or TER [10 sessions of 30 min at 65% peak oxygen consumption (VO(2peak))] cycle exercise. Fasting plasma glucose, insulin, non-esterified fatty acids (NEFA), homeostasis model assessment of insulin sensitivity (HOMA-IR), body composition and VO(2peak) were assessed at baseline and approximately 72 h after the final training bout. Skeletal muscle biopsy samples were also obtained before and 72 h after training and analysed for AS160 phosphorylation and COX II, COX IV, GLUT-4, Nur77 and SIRT1 protein expression.
  
  
  RESULTS
  No changes in BMI, body composition, VO(2peak), glucose, insulin, NEFA and HOMA-IR were observed after training, either within or between groups. Skeletal muscle markers of glucose metabolism and mitochondrial function also remained unaltered after 2 weeks of exercise training.
  
  
  CONCLUSIONS
  Our findings show that 2 weeks of reduced-volume SIT or TER did not elicit any measurable metabolic adaptations in sedentary obese men. Further work is needed to determine the minimal amount of exercise required for short-term adaptations in this population.
authors.affiliation: School of Exercise and Health Sciences, Edith Cowan University, Perth, Western Australia.
authors.forename: J R
authors.initials: JR
authors.lastname: Skleryk
authors.forename: L G
authors.initials: LG
authors.lastname: Karagounis
authors.forename: J A
authors.initials: JA
authors.lastname: Hawley
authors.forename: M J
authors.initials: MJ
authors.lastname: Sharman
authors.forename: P B
authors.initials: PB
authors.lastname: Laursen
authors.forename: G
authors.initials: G
authors.lastname: Watson
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004734:Energy Metabolism / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000378:metabolism / Q000628:therapy*; D010101:Oxygen Consumption / Q000502:physiology; D010766:Phosphorylation / Q000502:physiology; D057185:Sedentary Behavior
chemical_list: D005230:Fatty Acids, Nonesterified; D051275:Glucose Transporter Type 4; D007328:Insulin
keywords: exercise; glucose uptake; obesity; skeletal muscle