title: Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis.
abstract: This study aimed to establish the effect of a diet enriched with green-lipped mussel (GLM) on pain and functional outcomes in osteoarthritic dogs. Twenty-three client-owned dogs with osteoarthritis (OA) were fed a balanced control diet for 30 d and then a GLM-enriched balanced diet for the next 60 d. We assessed peak vertical force (PVF), which is considered to be the gold standard method, at Day (D)0 (start), D30 (end of control diet), and D90 (end of GLM-enriched diet). The owners completed a client-specific outcome measure (CSOM), which is a pain questionnaire, once a week. Motor activity (MA) was continuously recorded in 7 dogs for 12 wk. Concentrations of plasma omega-3 fatty acids were quantified as indicative of diet change. Statistical analyses were linear-mixed models and multinomial logistic regression for repeated measures. The GLM diet (from D30 to D90) resulted in an increase in concentrations of plasma omega-3 fatty acids (P < 0.016) and improvement of PVF (P = 0.003). From D0 to D30, PVF did not significantly change (P = 0.06), which suggests that the GLM diet had a beneficial effect on gait function. Moreover, PVF (P = 0.0004), CSOM (P = 0.006), and MA (P = 0.02) improved significantly from D0 to D90. In general, the balanced control diet could have contributed to reduced OA symptoms, an effect that was subsequently amplified by the GLM diet.
authors.affiliation: Research Group in Animal Pharmacology of Quebec (GREPAQ), Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, Université de Montréal, PO Box 5000, St-Hyacinthe, Quebec J2S 7C6, Canada.
authors.forename: Pascale
authors.initials: P
authors.lastname: Rialland
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bichot
authors.forename: Bertrand
authors.initials: B
authors.lastname: Lussier
authors.forename: Maxim
authors.initials: M
authors.lastname: Moreau
authors.forename: Francis
authors.initials: F
authors.lastname: Beaudry
authors.forename: Jérôme R E
authors.initials: JR
authors.lastname: del Castillo
authors.forename: Dominique
authors.initials: D
authors.lastname: Gauvin
authors.forename: Eric
authors.initials: E
authors.lastname: Troncy
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004032:Diet / Q000662:veterinary*; D004285:Dogs; D004311:Double-Blind Method; D008137:Longitudinal Studies; D009043:Motor Activity; D010003:Osteoarthritis / Q000178:diet therapy / Q000662:veterinary*; D010146:Pain / Q000662:veterinary*; D049883:Perna / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal