title: Phenanthrenes, 9,10-dihydrophenanthrenes, bibenzyls with their derivatives, and malate or tartrate benzyl ester glucosides from tubers of Cremastra appendiculata.
abstract: Eleven previously unknown compounds and 23 known compounds, including 20 phenanthrene or 9,10-dihydrophenanthrene derivatives, five bibenzyls, seven malate or tartrate benzyl ester glucosides, adenosine and gastrodin were isolated from tubers of Cremastra appendiculata. Among the obtained compounds, two are the first isolated dimers with one phenanthrene or bibenzyl unit connected to C-3 of 2,3,4,5-tetrahydro-phenanthro[2,1-b]furan moiety. In addition, 33 of these compounds were evaluated in vitro for their cytotoxic activity against two cancer cell lines. Among the compounds examined, one compound showed moderate cytotoxic activity, while five showed weak cytotoxic activity against the A549 cell line.
authors.affiliation: Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, ZhangJiang Hi-Tech Park, Shanghai 201203, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Guan
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Meng
authors.forename: Yi-Bei
authors.initials: YB
authors.lastname: Zhang
authors.forename: Chun-Ru
authors.initials: CR
authors.lastname: Cheng
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Shi
authors.forename: Rui-Hong
authors.initials: RH
authors.lastname: Feng
authors.forename: Feng
authors.initials: F
authors.lastname: Zeng
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Wu
authors.forename: Jing-Xian
authors.initials: JX
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Chen
authors.forename: Kai-Shun
authors.initials: KS
authors.lastname: Bi
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001554:Benzene / Q000737:chemistry; D001632:Bibenzyls / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004952:Esters / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008293:Malates / Q000737:chemistry; D029595:Orchidaceae / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D035281:Plant Tubers / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013644:Tartrates / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D004952:Esters; D005960:Glucosides; D008293:Malates; D010616:Phenanthrenes; D013644:Tartrates; C031181:phenanthrene; C030298:malic acid; D001554:Benzene; C029768:tartaric acid
keywords: 2,3,4,5-Tetrahydro-phenanthro[2,1-b]furan; 9,10-Dihydrophenanthrene; Bibenzyl; Cremastra appendiculata; Malate benzyl ester glucoside; Orchidaceae; Phenanthrene; Tartrate benzyl ester glucoside