title: Algorithm-based prediction of HIV-1 subtype D coreceptor use.
abstract: We compared the coreceptor tropism-predicting performance of a specific genotypic algorithm for HIV-1 subtype D and that of the geno2pheno algorithm with different cutoffs. The D-specific algorithm and geno2pheno with a false-positivity rate cutoff of 2.5% had the same concordance with the phenotypic determination. The geno2pheno algorithm with a false-positivity rate cutoff of 2.5%, more sensitive but slightly less specific, seems to be an appropriate alternative.
authors.affiliation: Laboratoire de Virologie, CHU de Caen, Caen, France. Dina, dina-j@chu-caen.fr
authors.forename: Julia
authors.initials: J
authors.lastname: Dina
authors.forename: Stephanie
authors.initials: S
authors.lastname: Raymond
authors.forename: Anne
authors.initials: A
authors.lastname: Maillard
authors.forename: Helene
authors.initials: H
authors.lastname: Le Guillou-Guillemette
authors.forename: Audrey
authors.initials: A
authors.lastname: Rodalec
authors.forename: Agnes
authors.initials: A
authors.lastname: Beby-Defaux
authors.forename: Genevieve
authors.initials: G
authors.lastname: Giraudeau
authors.forename: Sophie
authors.initials: S
authors.lastname: Vallet
authors.forename: Thomas
authors.initials: T
authors.lastname: Mourez
authors.forename: Christopher
authors.initials: C
authors.lastname: Payan
authors.forename: Astrid
authors.initials: A
authors.lastname: Vabret
authors.forename: Annick
authors.initials: A
authors.lastname: Ruffault
authors.forename: Virginie
authors.initials: V
authors.lastname: Ferre
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Plantier
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D005838:Genotype; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D015728:Receptors, HIV / Q000378:metabolism*; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA; D056189:Viral Tropism; D053585:Virus Attachment
chemical_list: D012367:RNA, Viral; D015728:Receptors, HIV