title: [The use of hydroxamic acids and sodium nitrate to enhance the antitumor effect of cyclophosphamide].
abstract: It has been showed that the introduction of nitrocompounds (as nitic oxide donors) in to the compositions of cyclophosphamide and hydroxamic acids for curing animals having leukemia P-388 increased duration of life by 290%. Thereby 40% of animals have recovered. The therapeutic dose cyclophosphamide have been reduced by 6 times.
authors.forename: T N
authors.initials: TN
authors.lastname: Bogatyrenko
authors.forename: Z V
authors.initials: ZV
authors.lastname: Kuropteva
authors.forename: T E
authors.initials: TE
authors.lastname: Sashenkova
authors.forename: L M
authors.initials: LM
authors.lastname: Baĭder
authors.forename: N P
authors.initials: NP
authors.lastname: Konovalova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006877:Hydroxamic Acids / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009566:Nitrates / Q000494:pharmacology*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D006877:Hydroxamic Acids; D009566:Nitrates; C031618:sodium nitrate; D003520:Cyclophosphamide