title: [Evaluation of the efficacy and tolerance of ibandronic acid in patients with osteoarthrosis in the knee joints concurrent with osteoporosis: a pilot study].
abstract: OBJECTIVE
  To evaluate the efficacy and tolerance of ibandronic acid (bonviva) in patients with osteoporosis (OP) concurrent with osteoarthrosis (OA) in the knee joints (KJ).
  
  
  METHODS
  Twenty female outpatients aged 56 to 77 years with postmonopausal OP and primary KJ OA were examined. All the patients took bonviva in a dose of 150 mg monthly during a year.
  
  
  RESULTS
  During the treatment, the patients showed a significant reduction in the values of all components of the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) (pain intensity from 51.7 +/- 11.6 to 34.6 +/- 20.7 mm, stiffness from 96.0 +/- 55.6 to 78.5 +/- 46.6 mm, and functional failure from 783.6 +/- 333.2 to 657.8 +/- 360.9 mm according to a visual analogue scale), the Oswestry disability index, as well as in the concentration of markers for bone resorption and cartilage degradation. The need for nonsteroidal anti-inflammatory drugs was stated to decrease.
  
  
  CONCLUSIONS
  Bonviva therapy results in a significant reduction in pain, KJ stiffness, and locomotor functional failure in patients with gonoarthrosis.
authors.forename: L I
authors.initials: LI
authors.lastname: Alekseeva
authors.forename: E M
authors.initials: EM
authors.lastname: Zaitseva
authors.forename: E P
authors.initials: EP
authors.lastname: Sharapova
authors.forename: E A
authors.initials: EA
authors.lastname: Taskina
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnov
authors.forename: N V
authors.initials: NV
authors.lastname: Demin
authors.forename: E N
authors.initials: EN
authors.lastname: Aleksandrova
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001862:Bone Resorption / Q000188:drug therapy; D002356:Cartilage / Q000473:pathology; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D000077557:Ibandronic Acid; D008124:Locomotion / Q000187:drug effects; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D010147:Pain Measurement; D010865:Pilot Projects; D012720:Severity of Illness Index
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077557:Ibandronic Acid