title: Administration of ascorbic acid to prevent bleaching-induced tooth sensitivity: a randomized triple-blind clinical trial.
abstract: This study evaluated the effect of ascorbic acid, 500 mg every eight hours, on bleaching-induced tooth sensitivity. A triple-blind, parallel design, and placebo-controlled randomized clinical trial was conducted on 39 adults. The pills (placebo or ascorbic acid) were administered three times per day for 48 hours; the first dose was given one hour prior to each bleaching session. Two bleaching sessions with 35% hydrogen peroxide gel were performed with a one-week interval. Tooth sensitivity was recorded up to 48 hours after bleaching. The color evaluation was performed before and 30 days after bleaching. The absolute risk and intensity of tooth sensitivity were evaluated by Fisher exact and Mann-Whitney U-tests, respectively. Color changes were evaluated by unpaired t-test (α=0.05). There were no significant differences in the absolute risk and intensity of tooth sensitivity and color change between the groups. Both groups showed a similar risk of tooth sensitivity (p>0.05). The perioperative use of an antioxidant, such as ascorbic acid (500 mg, three times daily) perorally, was not able to prevent bleaching-induced tooth sensitivity or reduce its intensity.
authors.forename: E A
authors.initials: EA
authors.lastname: de Paula
authors.forename: S
authors.initials: S
authors.lastname: Kossatz
authors.forename: D
authors.initials: D
authors.lastname: Fernandes
authors.forename: A D
authors.initials: AD
authors.lastname: Loguercio
authors.forename: A
authors.initials: A
authors.lastname: Reis
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000139:chemically induced / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D010147:Pain Measurement / Q000379:methods; D014073:Tooth Bleaching / Q000009:adverse effects*; D058205:Tooth Bleaching Agents / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D058205:Tooth Bleaching Agents; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid