title: Sleep deprivation and neurobehavioral functioning in children.
abstract: Sleep deprivation can result in significant impairments in daytime neurobehavioral functioning in children. Neural substrates impacted by sleep deprivation include the prefrontal cortex, basal ganglia and amygdala and result in difficulties with executive functioning, reward anticipation and emotional reactivity respectively. In everyday life, such difficulties contribute to academic struggles, challenging behaviors and public health concerns of substance abuse and suicidality. In this article, we aim to review 1) core neural structures impacted by sleep deprivation; 2) neurobehavioral problems associated with sleep deprivation; 3) specific mechanisms that may explain the relationship between sleep disturbances and neurobehavioral dysfunction; and 4) sleep problems reported in common neurodevelopmental disorders including attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorders (ASDs).
authors.affiliation: Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: Kiran.maski@childrens.harvard.edu.
authors.forename: Kiran P
authors.initials: KP
authors.lastname: Maski
authors.forename: Sanjeev V
authors.initials: SV
authors.lastname: Kothare
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D056344:Executive Function / Q000502:physiology*; D006801:Humans; D012892:Sleep Deprivation / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*
keywords: Attention deficit hyperactivity disorder; Autistic spectrum disorder; Behavior; Children; Executive functioning; Sleep deprivation