title: Impact of hepatitis B and delta virus co-infection on liver disease in Mauritania: a cross sectional study.
abstract: OBJECTIVE
  Mauritania is a highly endemic region for hepatitis B (HBV) and delta (HDV) viruses. No data are available on HDV's impact on the severity of liver disease in consecutive HBV-infected patients in Africa. This study evaluated the degree of liver fibrosis in a cohort of chronic HBV carriers.
  
  
  METHODS
  Three-hundred consecutive HBV-infected Mauritanian patients were checked for HDV infection via the detection of anti-HDV antibodies (Ab) and viral RNA. HBV- vs. HBV/HDV-infected patients were compared by physical examination, biological analyses, and the APRI (aspartate aminotransferase to platelet ratio index) and FibroMeter tests for determination of liver fibrosis.
  
  
  RESULTS
  More than 30% of the patients had anti-HDVAb. Among these, 62.2% were HDV-RNA positive. Co-infected patients were older (>8-years) than HBV-mono-infected patients. They had more liver tests abnormalities and clinical or ultrasound signs of liver fibrosis. APRI and FibroMeter scores were also significantly increased in these patients. In multivariate analysis, beyond HDVAb, male gender and HBV-VL >3.7 log IU/mL were the only markers linked to significant liver fibrosis.
  
  
  CONCLUSIONS
  In Mauritania, HDV co-infection worsens liver disease, both clinically and biologically, as confirmed by the APRI and FibroMeter tests. These tests may be useful for the management of delta hepatitis, which is a major health problem in Mauritania.
authors.affiliation: Laboratoire de virologie, CHU Angers, France; Laboratoire HIFIH, UPRES EA3859 Faculté de Médecine d'Angers, France. Electronic address: FrLunel-Fabiani@chu-angers.fr.
authors.forename: Françoise
authors.initials: F
authors.lastname: Lunel-Fabiani
authors.forename: Wael
authors.initials: W
authors.lastname: Mansour
authors.forename: Abdellahi Ould
authors.initials: AO
authors.lastname: Amar
authors.forename: Mohamed
authors.initials: M
authors.lastname: Aye
authors.forename: Frédéric
authors.initials: F
authors.lastname: Le Gal
authors.forename: F-Zahra Fall
authors.initials: FZ
authors.lastname: Malick
authors.forename: Lô
authors.initials: L
authors.lastname: Baïdy
authors.forename: Ségolène
authors.initials: S
authors.lastname: Brichler
authors.forename: Pascal
authors.initials: P
authors.lastname: Veillon
authors.forename: Alexandra
authors.initials: A
authors.lastname: Ducancelle
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Gordien
authors.forename: Michel
authors.initials: M
authors.lastname: Rosenheim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D060085:Coinfection / Q000453:epidemiology / Q000821:virology*; D003430:Cross-Sectional Studies; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D006509:Hepatitis B / Q000453:epidemiology / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification; D003699:Hepatitis D / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D003698:Hepatitis Delta Virus / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008435:Mauritania / Q000453:epidemiology; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D006508:Hepatitis Antibodies
keywords: APRI; Cirrhosis; FibroMeter; HBV; HDV; Liver fibrosis; Mauritania