title: The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development.
abstract: The CULLIN family of E3 ubiquitin ligases are important regulators of plant development and function. A newly identified class of CULLIN4-RING-E3 ligases (CRL4s) interacts with substrate receptors referred to as DDB1-CUL4 ASSOCIATED FACTORS (DCAFs) via a DDB1 linker protein. We have previously reported that the WD40 protein WDR55 interacts with DDB1A and is thus a putative DCAF. Mutants of WDR55 are embryo lethal, suggesting that a DDB1(WDR55) complex could regulate embryo and endosperm development. Here we report that a weak allele homozygous for wdr55 display pleiotropic phenotypes in the seedling and adult stages, suggesting a novel regulatory role for WDR55 in vegetative development.
authors.affiliation: Department of Biosciences; University of Oslo; Oslo, Norway.
authors.forename: Katrine N
authors.initials: KN
authors.lastname: Bjerkan
authors.forename: Paul E
authors.initials: PE
authors.lastname: Grini
mesh_terms: D017360:Arabidopsis / Q000254:growth & development* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D018548:Cotyledon / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D018517:Plant Roots / Q000378:metabolism; D018547:Plant Stems / Q000254:growth & development; D011485:Protein Binding; D036226:Seedlings / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; C517426:DDB1a protein, Arabidopsis; D004268:DNA-Binding Proteins; C000588886:WDR55 protein, Arabidopsis; D005966:Glucuronidase
keywords: DDB1; WDR55; apical dominance; vegetative development