title: [Effect of plastoquinone derivative SkQ1 on benzo(a)pyrene-induced soft tissue carcinogenesis].
abstract: Ninety female SHR mice were subcutaneously injected with a single dose of 2 mg benzo(a)pyrene (BaP) dissolved in 0.2 ml of vegetable oil. Since the next day after BaP injection mice were started to treat with mitochondria-targeted antioxidant SkQ1 at the doses of 5 and 50 nmol/kg/day in drinking water. Control animals received tap water. Study was finished by 358th day. Number of tumor-bearing mice increased in all groups exposed to BaP but retarded since 20th week in SkQ1-treated groups in comparison with control. Maximal tumor volume gain was observed in control mice resulting in premature death. By the 30th week of study only 20% of control animals survived, whereas SkQ1 treatment increased survival up to 30% at the dose of 5 nmol and 40% at the dose of 50 nmol. By the 40th week mean tumor volume in 5 and 50 nmol SkQ1-treated mice was 13 and 21 cm3 respectively, whereas in control--40 cm3. In SkQ1-treated mice pneumonia was observed rarely as compared with controls. It could be supposed, SkQ1 at the doses of 5 and 50 nmol/kg/day retarted BaP-induced soft tissue carcinogenesis in SHR mice.
authors.forename: I V
authors.initials: IV
authors.lastname: Anikin
authors.forename: I G
authors.initials: IG
authors.lastname: Popovich
authors.forename: M L
authors.initials: ML
authors.lastname: Tyndyk
authors.forename: M A
authors.initials: MA
authors.lastname: Zabezhinskiĭ
authors.forename: M N
authors.initials: MN
authors.lastname: Iurova
authors.forename: V P
authors.initials: VP
authors.lastname: Skulachëv
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001564:Benzo(a)pyrene; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D060766:Drinking Water; D005260:Female; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D010971:Plastoquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D060766:Drinking Water; D001564:Benzo(a)pyrene; D010971:Plastoquinone