title: Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature.
abstract: Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal neoplasm that arises in subcutaneous tissue, with that in the oral cavity extremely rare. We present a case of malignant OFMT in the tongue. A 26-year-old male noticed a painless mass in the tongue, which was extracted at a general hospital. Four years later, the tumor recurred and was resected at our department. Histologically, the recurrent tumor was composed of the closely packed cells positive for vimentin and S-100 proliferating in a nodular fashion. It showed high cellularity and mitotic activity. In the primary tumor, some tumor cells were arranged in a diffuse or cord-like manner within an abundant fibromyxoid matrix, along with a small amount of metaplastic ossification, corresponding with the histopathological characteristic of OFMT. Accordingly, a diagnosis of malignant OFMT arising in typical OFMT was established. This is the first reported case of malignant OFMT in the tongue. Long-term follow-up is needed for confirmation of prognosis and biological behavior.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Institute of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan. otkouji@hiroshima-u.ac.jp
authors.forename: Kouji
authors.initials: K
authors.lastname: Ohta
authors.forename: Masayuki
authors.initials: M
authors.lastname: Taki
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ogawa
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Ono
authors.forename: Kuniko
authors.initials: K
authors.lastname: Mizuta
authors.forename: Shinichi
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Takata
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kamata
mesh_terms: D000328:Adult; D005350:Fibroma / Q000473:pathology*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D014062:Tongue Neoplasms / Q000473:pathology*