title: "Oxygen with love" and diode laser treatment decreases comorbidity and avoidable blindness due to retinopathy of prematurity: results achieved in the past 12 years.
abstract: OBJECTIVE
  To determine whether the "Oxygen with Love" (OWL) and diode laser treatment provided in a neonatal intensive care unit has reduced the risk of avoidable blindness caused by retinopathy of prematurity (ROP) over the past decade.
  
  
  METHODS
  A prospective observational cohort study was performed, in which 351 infants were examined for ROP. The inclusion conditions were as follows: preterm infants, birthweight <1500 g or <32 weeks' gestational age, and birth between 1 Jan 2000 to 31 August 2012. From mid-2009, the OWL program was implemented and the ventilation protocols for such infants were amended. We tested whether the incidence of unfavorable structural outcomes of ROP had decreased following these changes.
  
  
  RESULTS
  From 2004 to 2012, the survival rates of younger children increased (p < 0.003). From 2005 to 2012, laser treatment rather than cryotherapy was applied, and the incidence of unfavorable structural outcomes of ROP fell from 13% to 5.6% (not significant). From 2009 to 2012, the incidence of ROP decreased from 55% to 29% (p < 0.002). From 1 August 2009 to 31 August 2012, there was less need for ablative treatment for premature infants, with the rate falling from 11.81% to 3.9% (p < 0.03). This improvement was significantly associated with a reduction in the number of days of intubation (p < 0.0017), lower rates of sepsis (p < 0.003), and improvements in postnatal weight gain (p < 0.0002).
  
  
  CONCLUSIONS
  The introduction of the OWL program, together with lower rates of sepsis, improvements in postnatal weight gain, and the use of diode laser treatment, has reduced the incidence of unfavorable structural outcomes of ROP.
authors.affiliation: Department of Ophthalmology, San Cecilio University Hospital, Granada, Spain. Electronic address: jopalace@hotmail.com.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Garcia-Serrano
authors.forename: José
authors.initials: J
authors.lastname: Uberos Fernández
authors.forename: Roberto
authors.initials: R
authors.lastname: Anaya-Alaminos
authors.forename: Antonio
authors.initials: A
authors.lastname: Jerez-Calero
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Padilla-Torres
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: Ramírez-Garcia
authors.forename: Raquel
authors.initials: R
authors.lastname: Piñar-Molina
mesh_terms: D001766:Blindness / Q000209:etiology / Q000517:prevention & control*; D015897:Comorbidity; D006801:Humans; D007231:Infant, Newborn; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D028022:Low-Level Light Therapy; D010100:Oxygen; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000150:complications* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D010100:Oxygen
keywords: comorbidity; newborn; oxygen; retinopathy of prematurity