title: [A quantitative investigation of E2F1-regulated cell cycle compensation mechanism].
abstract: OBJECTIVE
  To explore the core mechanism of cell cycle compensation using a mathematical model.
  
  
  METHODS
  A set of ordinary differential equations were used to describe the interactions between the core cell cycle molecules. Continuous and cyclic changes of the concentrations of these molecules were computed to capture the discrete events of molecular interactions.
  
  
  RESULTS
  The calculated molecule concentrations and captured signaling events agreed with the experimental results.
  
  
  CONCLUSIONS
  E2F transcription factor 1 is the pivotal element linking the positive and negative feedbacks and regulating G1/S and G2/M phase compensation.
authors.affiliation: Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China. liuwenyin@126.com
authors.forename: Wenyin
authors.initials: W
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002453:Cell Cycle; D004330:Drosophila / Q000166:cytology; D050687:E2F1 Transcription Factor; D025461:Feedback, Physiological; D008962:Models, Theoretical
chemical_list: D050687:E2F1 Transcription Factor