title: The Kondrat'eva reaction in flow: direct access to annulated pyridines.
abstract: A continuous flow inverse-electron-demand Kondrat'eva reaction has been developed that provides direct access to cycloalka[c]pyridines from unactivated oxazoles and cycloalkenes. Annulated pyridines obtained by this one-step process are valuable scaffolds for medicinal chemistry.
authors.affiliation: F. Hoffmann-La Roche AG, pRED, Pharma Research & Early Development, Small Molecule Research, Medicinal Chemistry, Grenzacherstrasse 124, 4070 Basel, Switzerland.
authors.forename: Johannes
authors.initials: J
authors.lastname: Lehmann
authors.forename: Thibaut
authors.initials: T
authors.lastname: Alzieu
authors.forename: Rainer E
authors.initials: RE
authors.lastname: Martin
authors.forename: Robert
authors.initials: R
authors.lastname: Britton
mesh_terms: D002626:Chemistry, Pharmaceutical; D003516:Cycloparaffins / Q000737:chemistry*; D004583:Electrons; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D003516:Cycloparaffins; D010080:Oxazoles; D011725:Pyridines