title: Effect of ipsilateral ureteric obstruction on contralateral kidney and role of renin angiotensin system blockade on renal recovery in experimentally induced unilateral ureteric obstruction.
abstract: OBJECTIVE
  To study, the effects of ipsilateral ureteric obstruction on contralateral kidney and the role of renin angiotensin system (RAS) blockade on renal recovery in experimentally induced unilateral ureteric obstruction.
  
  
  METHODS
  Unilateral upper ureteric obstruction was created in 96 adult Wistar rats that were reversed after pre-determined intervals. Losartan and Enalapril were given to different subgroups of rats following relief of obstruction.
  
  
  RESULTS
  The severity of dilatation on the contralateral kidney varied with duration of ipsilateral obstruction longer the duration more severe the dilatation. There is direct correlation between renal parenchymal damage, pelvi-ureteric junction (PUJ) fibrosis, inflammation and severity of pelvi-calyceal system dilatation of contralateral kidney with duration of ipsilateral PUJ obstruction.
  
  
  CONCLUSIONS
  Considerable injury is also inflicted to the contralateral normal kidney while ipsilateral kidney remains obstructed. Use of RAS blocking drugs has been found to significantly improve renal recovery on the contralateral kidney. It can, thus, be postulated that contralateral renal parenchymal injury was mediated through activation of RAS.
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Shasanka S
authors.initials: SS
authors.lastname: Panda
authors.forename: Minu
authors.initials: M
authors.lastname: Bajpai
authors.forename: Anand
authors.initials: A
authors.lastname: Sinha
authors.forename: Saumyaranjan
authors.initials: S
authors.lastname: Mallick
authors.forename: Mehar C
authors.initials: MC
authors.lastname: Sharma
keywords: Renin angiotensin system; ureteric obstruction; ureteropelvic junction obstruction