title: GC-MS investigation and acetylcholinesterase inhibitory activity of Galanthus rizehensis.
abstract: GC-MS (gas chromatography-mass spectrometry) analyses of alkaloids in the aerial parts and bulbs of Galanthus rizehensis Stern (Amaryllidaceae), collected during two different vegetation periods, was performed. Twenty three alkaloids were identified in four different alkaloid extracts. Acetylcholinesterase (AChE) inhibitory activities of the alkaloid extracts were tested. Both the highest alkaloid diversity and the most potent inhibitory activity (IC50 12.94 microg/ml) were obtained in extracts from the bulbs of G. rizehensis collected during the fruiting period.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey. buket.bozkurt@ege.edu.tr
authors.forename: Buket Bozkurt
authors.initials: BB
authors.lastname: Sarikaya
authors.forename: Nehir Unver
authors.initials: NU
authors.lastname: Somer
authors.forename: Gulen Irem
authors.initials: GI
authors.lastname: Kaya
authors.forename: Mustafa Ali
authors.initials: MA
authors.lastname: Onur
authors.forename: Jaume
authors.initials: J
authors.lastname: Bastida
authors.forename: Strahil
authors.initials: S
authors.lastname: Berkov
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*
chemical_list: D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase