title: X-ray luminescence optical tomography imaging: experimental studies.
abstract: We present a hybrid imaging modality, x-ray luminescence optical tomography (XLOT), in which collimated x-ray beams are used to excite phosphor-based contrast agents. Images are reconstructed from the optical signals, using the known x-ray beam location and spatial extent as priors. We demonstrate XLOT using phantom experiments with deep targets and show that the reconstructed signal varies by <12% when the depth changes from 4.2 to 7.7 mm. For simple source distributions, we find as few as two orthogonal projection measurements are sufficient for XLOT reconstruction.
authors.affiliation: School of Engineering, University of California, Merced, California 95343, USA. cli32@ucmerced.edu
authors.forename: Changqing
authors.initials: C
authors.lastname: Li
authors.forename: Kun
authors.initials: K
authors.lastname: Di
authors.forename: Julien
authors.initials: J
authors.lastname: Bec
authors.forename: Simon R
authors.initials: SR
authors.lastname: Cherry
mesh_terms: D007091:Image Processing, Computer-Assisted; D049449:Luminescence; D061848:Optical Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D014056:Tomography, X-Ray / Q000379:methods*