title: Self-limited effusion large B-cell lymphoma: two cases of effusion lymphoma maintaining remission after drainage alone.
abstract: We report two cases of human herpesvirus-8 (HHV-8)-negative large B-cell lymphoma involving pericardial and/or pleural effusion that regressed after drainage alone. Case 1 is a 70-year-old man showing massive pericardial effusion. Cytology of the drained effusion showed monotonous infiltration of CD3-, CD20+, CD79a+, and CD138- large B-cells. Monoclonality was shown by Southern blot analysis. Case 2 is a 70-year-old man with massive pericardial and bilateral pleural effusion. Cytology of pericardial effusion showed infiltration of CD20+, CD45RO-, CD138-, immunoglobulin lambda chain+, and kappa chain- large B cells. In both cases, effusion resolved after drainage and no relapse has been observed. HHV-8 was not demonstrated in either case. Clinical presentation of our two cases resembled primary effusion lymphoma (PEL), but cytomorphology, immunophenotype, and prognosis were clearly distinct from those of PEL. HHV-8-negative effusion lymphomas might include prognostically favorable self-limited tumors that could regress without any cytotoxic therapy.
authors.affiliation: Department of Pathology, Kansai Rosai Hospital, Amagasaki, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Nakatsuka
authors.forename: Hayato
authors.initials: H
authors.lastname: Kimura
authors.forename: Teruaki
authors.initials: T
authors.lastname: Nagano
authors.forename: Masashi
authors.initials: M
authors.lastname: Fujita
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanda
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwata
authors.forename: Koji
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000097:blood; D006338:Heart Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy* / Q000821:virology; D006566:Herpesviridae Infections; D019288:Herpesvirus 8, Human; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood / Q000473:pathology / Q000628:therapy* / Q000821:virology; D054685:Lymphoma, Primary Effusion / Q000097:blood / Q000473:pathology / Q000628:therapy* / Q000821:virology; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood; D010490:Pericardial Effusion / Q000097:blood / Q000473:pathology / Q000628:therapy* / Q000821:virology; D016066:Pleural Effusion, Malignant / Q000097:blood / Q000473:pathology / Q000628:therapy* / Q000821:virology; D012074:Remission Induction
chemical_list: D015703:Antigens, CD; D009363:Neoplasm Proteins