title: Fast genomic predictions via Bayesian G-BLUP and multilocus models of threshold traits including censored Gaussian data.
abstract: Because of the increased availability of genome-wide sets of molecular markers along with reduced cost of genotyping large samples of individuals, genomic estimated breeding values have become an essential resource in plant and animal breeding. Bayesian methods for breeding value estimation have proven to be accurate and efficient; however, the ever-increasing data sets are placing heavy demands on the parameter estimation algorithms. Although a commendable number of fast estimation algorithms are available for Bayesian models of continuous Gaussian traits, there is a shortage for corresponding models of discrete or censored phenotypes. In this work, we consider a threshold approach of binary, ordinal, and censored Gaussian observations for Bayesian multilocus association models and Bayesian genomic best linear unbiased prediction and present a high-speed generalized expectation maximization algorithm for parameter estimation under these models. We demonstrate our method with simulated and real data. Our example analyses suggest that the use of the extra information present in an ordered categorical or censored Gaussian data set, instead of dichotomizing the data into case-control observations, increases the accuracy of genomic breeding values predicted by Bayesian multilocus association models or by Bayesian genomic best linear unbiased prediction. Furthermore, the example analyses indicate that the correct threshold model is more accurate than the directly used Gaussian model with a censored Gaussian data, while with a binary or an ordinal data the superiority of the threshold model could not be confirmed.
authors.affiliation: Department of Agricultural Sciences, University of Helsinki, Helsinki FIN-00014.
authors.forename: Hanni P
authors.initials: HP
authors.lastname: Kärkkäinen
authors.forename: Mikko J
authors.initials: MJ
authors.lastname: Sillanpää
mesh_terms: D000465:Algorithms; D000818:Animals; D001499:Bayes Theorem; D016678:Genome; D008962:Models, Theoretical; D016011:Normal Distribution; D010641:Phenotype; D010944:Plants / Q000235:genetics
keywords: G-BLUP; GenPred; binary; censored Gaussian; genomic selection; multiocus association model; ordinal; shared data resources; threshold model