title: Metallic profile of whole blood and plasma in a series of 106 healthy volunteers.
abstract: In 2003, we simultaneously quantified 27 metals by inductively coupled plasma-mass spectrometry (ICP-MS) in the whole blood, plasma and urine of 100 healthy volunteers. We again determined the metallic profile in whole blood and plasma during 2012. ICP-MS validated multielementary method was performed for metals in whole blood and plasma. Whole blood vanadium and chromium were quantified using ICP-MS collision cell technology. The aims of the study were to compare and assess any changes in this profile, particularly due to the environment. Healthy male/female staff volunteers (n = 106) with no professional exposure to metals, or medication containing lithium, strontium; or food supplements with trace elements and vitamins and with no metal prosthesis were included. Tobacco consumption and the number of dental amalgams were recorded. Our results demonstrated a blood lead level that had drastically decreased, i.e. reduced by half, during this period (12.5 versus 26.3 µg/L, P < 0.0001). Known differences were observed between males and females for copper and zinc; cadmium and lead were higher in smokers. Median plasmatic mercury, a specific test for dental amalgam exposure, did not significantly increase (0.38 versus 0.28 µg/L, P = 0.11). The ICP-MS metallic profile is a very practical concept that is useful for clinical, forensic and environmental toxicology, including industrial hygiene monitoring.
authors.affiliation: Laboratoire de Pharmacocinétique et de Toxicologie Cliniques, Groupe Hospitalier du Havre, Le Havre, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Cesbron
authors.forename: Elodie
authors.initials: E
authors.lastname: Saussereau
authors.forename: Loïc
authors.initials: L
authors.lastname: Mahieu
authors.forename: Isabelle
authors.initials: I
authors.lastname: Couland
authors.forename: Michel
authors.initials: M
authors.lastname: Guerbet
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Goullé
mesh_terms: D000328:Adult; D000375:Aging / Q000378:metabolism; D001774:Blood Chemical Analysis / Q000379:methods*; D003723:Dental Amalgam / Q000737:chemistry*; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D057230:Limit of Detection; D008137:Longitudinal Studies; D008297:Male; D013058:Mass Spectrometry; D008628:Mercury / Q000097:blood; D008631:Mercury Radioisotopes / Q000097:blood; D008670:Metals / Q000097:blood*; D008875:Middle Aged; D010949:Plasma / Q000737:chemistry*; D011786:Quality Control; D012727:Sex Characteristics; D013056:Spectrophotometry, Ultraviolet; D055815:Young Adult
chemical_list: D007202:Indicators and Reagents; D008631:Mercury Radioisotopes; D008670:Metals; D003723:Dental Amalgam; D008628:Mercury