title: Biological variability and the emergence of multidrug-resistant tuberculosis.
abstract: A new study demonstrates that bacterial mutation rates associated with the Mycobacterium tuberculosis lineage most commonly linked to multidrug-resistant tuberculosis are multifold higher than shown in previous studies. This discovery, when considered together with recent findings on pharmacokinetic variability in patients, leads to new models of how multidrug-resistant tuberculosis arises, with direct therapeutic implications.
authors.forename: Tawanda
authors.initials: T
authors.lastname: Gumbo
mesh_terms: D021821:Communicable Diseases, Emerging / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D006801:Humans; D059645:Mutation Rate; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D018088:Tuberculosis, Multidrug-Resistant / Q000382:microbiology*