title: Probing the depths of cellular senescence.
abstract: Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway.
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Baker
authors.forename: John M
authors.initials: JM
authors.lastname: Sedivy
mesh_terms: D016922:Cellular Senescence; D002843:Chromatin / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*
chemical_list: D002843:Chromatin