title: Atherosclerosis, biomarkers of atherosclerosis and Alzheimer's disease.
abstract: Alzheimer's disease (AD) is the most prevalent type of dementia, involving progressive deterioration of neuronal networks. Although the pathophysiological mechanism of AD is not fully elucidated, apart from β-amyloid and tau protein, a diverse number of factors such as cardiovascular risk factors, inflammation, and lipids metabolism may play a significant role. Numerous epidemiological and laboratory studies support vascular injury and inflammation, as key pathological processes. The present review is focused on cardiovascular risk factors, lipids, and circulating biomarkers of inflammation, discussing them as independent mechanisms converging to the same final pathogenetic cascade of AD.
authors.affiliation: Departments of 1Neurology and.
authors.forename: Aidonio
authors.initials: A
authors.lastname: Fiolaki
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Tsamis
authors.forename: Haralampos J
authors.initials: HJ
authors.lastname: Milionis
authors.forename: Athanassios P
authors.initials: AP
authors.lastname: Kyritsis
authors.forename: Maria
authors.initials: M
authors.lastname: Kosmidou
authors.forename: Sotirios
authors.initials: S
authors.lastname: Giannopoulos
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism*; D050197:Atherosclerosis / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007249:Inflammation / Q000150:complications
chemical_list: D015415:Biomarkers; D016207:Cytokines; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol