title: Vitamin A status and hematological values in sickle cell disorder cases.
abstract: BACKGROUND
  Sickle cell anemia (SCA), which is an inherited blood disorder characterized primarily by chronic anemia and oxidative stress plays a major role in pathophysiology.
  
  
  OBJECTIVE
  This study aims to evaluate vitamin A (serum retinol) status and hematological parameters in children with homozygous and heterozygous sickle cell disorders and compared with age- and sex-matched healthy controls.
  
  
  METHODS
  A sample of 80 referred cases (37 sickle cell disorders and 43 normal cases) aged 2-40 years were included in the study. Hematological parameters were measured in cell counter and serum retinol by high-performance liquid chromatography.
  
  
  RESULTS
  The mean hemoglobin (Hb) and serum retinol were significantly lower among cases with sickle cell disease than in sickle cell trait and normal. Vitamin A deficiency (retinol < 20 μg/dl) reported to be higher in homozygous cases (46.2%) as compared to either heterozygous (29.2%) or control (23.2%) groups. Serum retinol was correlated directly with Hb, RBC count, and hematocrit levels, and inversely with percentage of sickling among sickle cell disorder cases.
  
  
  CONCLUSIONS
  The results indicate that deprived vitamin A status with inductive oxidative stress is mainly due to sickling and hemolysis in SCA cases.
authors.affiliation: Regional Medical Research Centre, Indian Council of Medical Research, Chandrasekharpur, Bhubaneswar, India.
authors.forename: Shuchismita
authors.initials: S
authors.lastname: Behera
authors.forename: Sujata
authors.initials: S
authors.lastname: Dixit
authors.forename: Gandham
authors.initials: G
authors.lastname: Bulliyya
authors.forename: Shantanu Kumar
authors.initials: SK
authors.lastname: Kar
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D018384:Oxidative Stress; D014801:Vitamin A / Q000097:blood*; D014802:Vitamin A Deficiency / Q000097:blood* / Q000150:complications*; D055815:Young Adult
chemical_list: D014801:Vitamin A