title: [Specifics of hormonal and energy balance in patients with hyperplasia and endometrial neoplasia with metabolic syndrome in the background].
abstract: We conducted a comparative investigation of the hormonal status (LH, FSH, estradiol, progesterone, testosterone, prolactin, SHBG), energy status (leptin, ghrelin, insulin), and carbohydrate and lipid metabolism in patients with endometrial hyperplasia and neoplasia (168 patients) with or without metabolic syndrome in the background. Patients with metabolic syndrome had a high frequency of elevated estrogen (72%), testosterone (65%), insulin (81%), leptin (68%). There was a marked increase in the basal level of luteinizing hormone, prolactin, index, LH/FSH, but decrease in FSH and progesterone. There were significant changes in carbohydrate and lipid metabolism. The possible mechanisms for the contribution of the investigated factors to the development of the pathological processes in the endometrium are presented.
authors.forename: A L
authors.initials: AL
authors.lastname: Chernyshova
authors.forename: L A
authors.initials: LA
authors.lastname: Kolomiets
authors.forename: N V
authors.initials: NV
authors.lastname: Bochkarëva
authors.forename: I V
authors.initials: IV
authors.lastname: Kondakova
mesh_terms: D000328:Adult; D000368:Aged; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004714:Endometrial Hyperplasia / Q000097:blood* / Q000150:complications* / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000097:blood* / Q000150:complications* / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D054439:Ghrelin / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism; D007986:Luteinizing Hormone / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications* / Q000378:metabolism; D008875:Middle Aged; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
chemical_list: D004040:Dietary Carbohydrates; D054439:Ghrelin; D012739:Gonadal Steroid Hormones; D007328:Insulin; D020738:Leptin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone