title: The agaricoglyceride of royal sun medicinal mushroom, Agaricus brasiliensis (higher basidiomycetes) is anti-inflammatory and reverses diabetic glycemia in the liver of mice.
abstract: The agaricoglyceride is a new fungal secondary metabolite that constitutes esters of chlorinated 4-hydroxy benzoic acid and glycerol. The objective of this study was to explore whether the administration of agaricoglyceride could correct hepatic glycemic metabolism dysfunction by attenuating inflammation in the liver. The effects of agaricoglycerides on tumor necrosis factor-α, interleukin-1β, vascular endothelial growth factor-α, interleukin-17, insulin secretion, adiponectin, leptin, hepatic glycogen, nuclear factor-κB activation, and total antioxidant activity were studied respectively. We demonstrated that administration of agaricoglycerides alleviated glycemic metabolism dysfunction, inflammation, and oxidative stress in mice. These data indicate that agaricoglyceride supplementation could restrain metabolic dysfunction through suppressing the nuclear factor-κB pathway as well as decreasing the levels of inflammatory cytokines and total antioxidant activities.
authors.affiliation: Department of Biochemistry and Molecular Biology, Harbin Medical University, Heilongjiang Harbin, People's Republic of China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Yu
authors.forename: Chunchao
authors.initials: C
authors.lastname: Han
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Qi
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Xu
authors.initials: X
authors.lastname: Gao
authors.forename: Chunjing
authors.initials: C
authors.lastname: Zhang
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000378:metabolism; D000364:Agaricus / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents; D001565:Benzoates / Q000737:chemistry / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D005989:Glycerides / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D020738:Leptin / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D051379:Mice; D011897:Random Allocation
chemical_list: D052242:Adiponectin; D000893:Anti-Inflammatory Agents; D001565:Benzoates; D001786:Blood Glucose; D005989:Glycerides; D007328:Insulin; D020738:Leptin; D008112:Liver Glycogen