title: Rhodium-catalyzed directed C-H cyanation of arenes with N-cyano-N-phenyl-p-toluenesulfonamide.
abstract: A Rh-catalyzed directed C-H cyanation reaction was developed for the first time as a practical method for the synthesis of aromatic nitriles. N-Cyano-N-phenyl-p-toluenesulfonamide, a user-friendly cyanation reagent, was used in the transformation. Many different directing groups can be used in this C-H cyanation process, and the reaction tolerates a variety of synthetically important functional groups.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Tian-Jun
authors.initials: TJ
authors.lastname: Gong
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.forename: Wan-Min
authors.initials: WM
authors.lastname: Cheng
authors.forename: Wei
authors.initials: W
authors.lastname: Su
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Zhao-Jing
authors.initials: ZJ
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
mesh_terms: D002384:Catalysis; D003486:Cyanides / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis*; D008689:Methacrylates / Q000737:chemistry; D008958:Models, Molecular; D009570:Nitriles / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*; D014050:Toluene / Q000031:analogs & derivatives* / Q000737:chemistry; D000096926:Benzenesulfonamides
chemical_list: D003486:Cyanides; D006841:Hydrocarbons, Aromatic; D008689:Methacrylates; D009570:Nitriles; D009943:Organophosphorus Compounds; D012238:Rhodium; D013449:Sulfonamides; D014050:Toluene; C074232:Phenyl-P adhesion promoting monomer; C013307:2-toluenesulfonamide; D000096926:Benzenesulfonamides