title: A protein pair with PIPs inside.
abstract: Oxysterol binding protein (OSBP) and many of its homologs transfer sterol in vitro, but in vivo, they are not major sterol transporters. In this issue of Structure, Tong and colleagues find that the yeast OSBP homolog, Osh3, binds PI(4)P but not sterol, supporting the view that PI(4)P regulation, not sterol transport, is the key activity for OSBP homologs.
authors.affiliation: UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK. tim.levine@ucl.ac.uk
authors.forename: Tim P
authors.initials: TP
authors.lastname: Levine
authors.forename: Anant K
authors.initials: AK
authors.lastname: Menon
mesh_terms: D002352:Carrier Proteins / Q000737:chemistry*; D018129:Phosphatidylinositol Phosphates / Q000737:chemistry*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry*
chemical_list: D002352:Carrier Proteins; C432936:OSH3 protein, S cerevisiae; D018129:Phosphatidylinositol Phosphates; D029701:Saccharomyces cerevisiae Proteins; C037178:phosphatidylinositol 4-phosphate