title: Microwave-assisted synthesis and spasmolytic activity of 4-indolylhexahydroquinoline derivatives.
abstract: In the present study a microwave-assisted one-pot method was applied for the synthesis of 18 novel condensed 1,4-dihydropyridines carrying the indole moiety. The compounds were achieved by the reaction of appropriate 1,3-cyclohexanedione, substituted indole carboxaldehyde derivative, alkyl acetoacetate and ammonium acetate in methanol, according to a modified Hantzsch reaction. The structure elucidation of the compounds was carried out by spectral methods including X-ray studies. Their spasmolytic activities through calcium channel blockade were assayed on isolated rat ileum. The obtained results indicated that the introduction of the brom atom on the indole ring altered the mentioned activity positively.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: El-Khouly
authors.forename: M G
authors.initials: MG
authors.lastname: Gündüz
authors.forename: C
authors.initials: C
authors.lastname: Cengelli
authors.forename: R
authors.initials: R
authors.lastname: Simşek
authors.forename: K
authors.initials: K
authors.lastname: Erol
authors.forename: C
authors.initials: C
authors.lastname: Safak
authors.forename: S Oztürk
authors.initials: SO
authors.lastname: Yıldırım
authors.forename: R J
authors.initials: RJ
authors.lastname: Butcher
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D008297:Male; D008872:Microwaves; D010276:Parasympatholytics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D010276:Parasympatholytics