title: [On the mechanism of ikaron-1 anti-naupathia action].
abstract: Pneumomicroinjection of vestibuloprotector ikaron-1 (Russia) in specific neurons of the medial vestibular nucleus (MVN) was studied in cats immobilized by muscle relaxants using microelectrode devices. The original preparation had a direct effect on the majority of MVN neurons (95 %). Thirty four neurons of 37 cells (92 %) developed an inhibitory response, only one cell (3 %) was activated and 2 neurons (5 %) were areactive. Therefore, the inhibitory reaction to the preparation was 34 times more often than excitatory. An investigation of the MVN neurons activity evoked by adequate stimulation of the vestibular apparatus showed that ikaron-1 attenuates the evoked response in 92 % cells. This phenomenon could be behind the ikaron-lantinaupathia action.
authors.forename: V V
authors.initials: VV
authors.lastname: Iasnetsov
authors.forename: V G
authors.initials: VG
authors.lastname: Motin
authors.forename: S K
authors.initials: SK
authors.lastname: Karsanova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Ivanov
authors.forename: N A
authors.initials: NA
authors.lastname: Chel'naia
mesh_terms: D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D008297:Male; D008845:Microinjections; D009041:Motion Sickness / Q000188:drug therapy* / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D059010:Single-Cell Analysis; D014149:Tranquilizing Agents / Q000494:pharmacology*; D058585:Vestibular Evoked Myogenic Potentials / Q000187:drug effects*; D014726:Vestibular Nuclei / Q000187:drug effects* / Q000502:physiology
chemical_list: D014149:Tranquilizing Agents