title: Follicular immunoblastic lymphoma: a clinicopathologic and immunohistochemical study of a case.
abstract: Primary follicular immunoblastic lymphoma (FIBL) is an extremely rare lymphoma. The positive expression of CD10 suggests the lymphoma originating from germinal centers (GC) and CD138-positive expression generally indicates plasmablastic or plasmacytic differentiation. We report such a rare case in a Chinese female patient and analyze the clinicopathologic and immunohistochemical features of this disease. PET-CT examination was performed to detect signs of systemic lymph node metastasis. We also discussed the differential diagnosis of FIBL from follicular lymphoma (FL) and reactive follicular hyperplasia (RFH). As a rare variant of human follicular lymphoma, FIBL is featured by a neoplastic overgrowth of intrafollicular immunoblasts. Compared with FL, FIBL has a greater chance to evolve into diffuse large B-cell lymphoma with therefore a poorer prognosis.
authors.affiliation: First Clinical Medical College, Department of Pathology, Southern Medical University, Guangzhou 510515, China. lmsh815@163.com
authors.forename: Xuanqiu
authors.initials: X
authors.lastname: He
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Ding
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000473:pathology*