title: Triterpene saponins from Tabellae Clinopodii.
abstract: Three new triterpene saponins, named Clinoposaponin A, Clinoposaponin B, and Clinoposaponin C along with three known triterpene saponins were isolated from the Tabellae Clinopodii. The structures of these compounds were elucidated by means of various spectroscopic analyses. All of the isolated compounds were tested against Hela, HCT-8, AGS, and MCF-7 human cancer cell lines and showed moderate cytotoxic activities with IC₅₀ values between 4.1 and 19.7 μM.
authors.affiliation: Ahhui University of Traditional Chinese Medicine, Hefei 230031, Anhui province, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Wang
authors.forename: Guoxu
authors.initials: G
authors.lastname: Ma
authors.forename: Mingliang
authors.initials: M
authors.lastname: Zhong
authors.forename: Shichun
authors.initials: S
authors.lastname: Yu
authors.forename: Xudong
authors.initials: X
authors.lastname: Xu
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Hu
authors.forename: Yizhu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Wei
authors.forename: Junshan
authors.initials: J
authors.lastname: Yang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; C083340:clinoposaponin I; D009828:Oleanolic Acid
keywords: Clinopodium; Cytotoxic activities; Saponins; Tabellae Clinopodii