title: Estimation of plasma lipids and its significance on histopathological grades in oral cancer: Prognostic significance an original research.
abstract: OBJECTIVE
  Alterations in the lipid profile have long been associated with various cancers because lipids play a key role in maintenance of cell integrity. This study was to estimate the plasma lipid levels in patients with oral cancer and to correlate the values with the histopathological grades.
  
  
  METHODS
  The study group included 50 patients with oral cancer aged between 20 and 60 years who had visited the Department of Oral Medicine and Radiology during the period of September 2005 to July 2007. After the histotopathological confirmation, their plasma lipid levels were estimated using auto analyzer and the data was statistically analyzed.
  
  
  RESULTS
  The study revealed a significant decrease in the total plasma lipid levels in patients with oral cancer in comparison with the standard values. Comparing the plasma lipid levels with the histopathological grades, we observed a significant variation in the levels of total cholesterol, very low density lipoprotein, low-density lipoprotein, high-density lipoprotein and triglycerides.
  
  
  CONCLUSIONS
  The variation in the levels of plasma cholesterol and other lipid constituents in patients with cancer might be due to their increased utilization by neoplastic cells for new membrane biosynthesis. This study was an attempt to estimate the plasma lipids in oral cancer patients and its significance on histopathological grades. We observed a relationship between lower plasma lipids and oral cancer. The result of our study strongly warrants an in-depth research with larger samples and a longer follow-up to consider the low plasma lipid status in oral cancer patients as a useful indicator to assess the course and prognosis of the disease.
authors.affiliation: Department of Oral Medicine and Radiology, Sree Mookambika Institute of Dental Sciences, Kulasekharam, Tamil Nadu, India.
authors.forename: Eugenia J
authors.initials: EJ
authors.lastname: Sherubin
authors.forename: Karthiga S
authors.initials: KS
authors.lastname: Kannan
authors.forename: Dhineksh N
authors.initials: DN
authors.lastname: Kumar
authors.forename: Isaac
authors.initials: I
authors.lastname: Joseph
keywords: Histopathological grading; lipids; oral cancer