title: Primary alkylboronic acids as highly active catalysts for the dehydrative amide condensation of α-hydroxycarboxylic acids.
abstract: Primary alkylboronic acids such as methylboronic acid and butylboronic acid are highly active catalysts for the dehydrative amide condensation of α-hydroxycarboxylic acids. The catalytic activities of these primary alkylboronic acids are much higher than those of the previously reported arylboronic acids. The present method was easily applied to a large-scale synthesis, and 14 g of an amide was obtained in a single reaction.
authors.affiliation: Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Yamashita
authors.forename: Akira
authors.initials: A
authors.lastname: Sakakura
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ishihara
mesh_terms: D000577:Amides / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D001896:Boron Compounds; D001897:Boronic Acids; D002264:Carboxylic Acids; C030433:n-butylboronic acid