title: Chaperonin-mediated protein folding.
abstract: We have been studying chaperonins these past twenty years through an initial discovery of an action in protein folding, analysis of structure, and elucidation of mechanism. Some of the highlights of these studies were presented recently upon sharing the honor of the 2013 Herbert Tabor Award with my early collaborator, Ulrich Hartl, at the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston. Here, some of the major findings are recounted, particularly recognizing my collaborators, describing how I met them and how our great times together propelled our thinking and experiments.
authors.affiliation: Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut 06510, USA. arthur.horwich@yale.edu
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Horwich
mesh_terms: D001671:Biochemistry / Q000266:history*; D018835:Chaperonin 10 / Q000737:chemistry / Q000378:metabolism; D018834:Chaperonin 60 / Q000737:chemistry / Q000378:metabolism; D018833:Chaperonins / Q000737:chemistry / Q000378:metabolism*; D003237:Connecticut; D049673:History, 20th Century; D049674:History, 21st Century; D017510:Protein Folding
chemical_list: D018835:Chaperonin 10; D018834:Chaperonin 60; D018833:Chaperonins
keywords: Chaperone Chaperonin; Molecular Chaperone; Polypeptide; Protein Folding; Protein Misfolding; Yeast