title: [Relationship between parental exposure to chemicals and risk of childhood acute leukemia].
abstract: OBJECTIVE
  To investigate the relationship between parental exposure to chemicals and the risk of childhood acute leukemia.
  
  
  METHODS
  An exploratory case-control study was conducted among 201 new cases of childhood acute leukemia under 15 years old who went to 3 children's hospitals in Shanghai, China from January 1, 2009 to December 31, 2010, as well as 201 sex- and age-matched children (as controls) who went to the child health care clinic or department of orthopedics in the above hospitals. A survey was performed by face-to-face interviews with children's mothers.
  
  
  RESULTS
  The risk factors for childhood acute leukemia might include maternal exposure to total chemicals (diesel oil, gasoline, paints, insecticides, pesticides, herbicides, and chemical fertilizers) from 3 months before pregnancy to the end of pregnancy (OR = 2.9, 95%CI = 1.1 ∼ 7.8), paternal exposure to insecticides (OR = 10.1, 95%CI = 1.2 ∼ 82.9) and chemical fertilizers (OR = 9.5, 95%CI = 1.1 ∼ 79.6) within 3 months before pregnancy, maternal working experiences in agriculture and forestry before pregnancy (OR = 8.4, 95%CI = 1.4 ∼ 50.2) and in spinning, leather processing, decoration, and vehicle repair before pregnancy (OR = 3.0, 95%CI = 1.2 ∼ 7.9) and during pregnancy (OR = 3.2, 95%CI = 1.1 ∼ 9.6), and paternal working experiences in agriculture and forestry (OR = 9.6, 95%CI = 2.1-44.8) and in spinning, leather processing, decoration, and vehicle repair (OR = 2.3, 95%CI = 1.1-5.0).
  
  
  CONCLUSIONS
  Parental exposure to chemicals may increase the risk of childhood acute leukemia in their offspring.
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yi-jin
authors.initials: YJ
authors.lastname: Gao
authors.forename: Sha
authors.initials: S
authors.lastname: Zhu
authors.forename: Xiao-jin
authors.initials: XJ
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Jin
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006801:Humans; D007938:Leukemia / Q000209:etiology*; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D018812:Paternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D012307:Risk Factors; D011795:Surveys and Questionnaires