title: Combined hepatocellular-cholangiocarcinoma in a Yellow-headed Amazon (Amazona oratrix).
abstract: A 9-year-old male Yellow-headed Amazon (Amazona oratrix) with a history of anorexia and vomiting died of a liver tumor. The tumor consisted of neoplastic cells with hepatocellular and cholangiocellular differentiations and their intermingled areas. Neoplastic hepatocytes showed islands or trabecular growth with vacuolated eosinophilic cytoplasm. Cells showing biliary differentiation formed ducts or tubules lined by cytokeratin AE1/AE3-positive epithelia, accompanied by desmoplasia consisting of myofibroblasts reacting to α-smooth muscle actin and desmin. The tumor was diagnosed as a combined hepatocellular-cholangiocarcinoma, which is very rare in the avian.
authors.affiliation: Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-ourai-kita, Izumisano city, Osaka 598-8531, Japan.
authors.forename: Anusha Hemamali
authors.initials: AH
authors.lastname: Tennakoon
authors.forename: Takeshi
authors.initials: T
authors.lastname: Izawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fujita
authors.forename: Yuki
authors.initials: Y
authors.lastname: Denda
authors.forename: Eiko
authors.initials: E
authors.lastname: Seto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasai
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kuwamura
authors.forename: Jyoji
authors.initials: J
authors.lastname: Yamate
mesh_terms: D046708:Amazona; D000818:Animals; D001715:Bird Diseases / Q000473:pathology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000662:veterinary*; D018281:Cholangiocarcinoma / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D006651:Histocytochemistry / Q000662:veterinary; D008113:Liver Neoplasms / Q000473:pathology / Q000662:veterinary*; D008297:Male