title: Paper-based chemiresistor for detection of ultralow concentrations of protein.
abstract: A new paper-based chemiresistor composed of a network of single-wall carbon nanotubes (SWCNTs) and anti-human immunoglobulin G (anti-HIgG) is reported herein. SWCNTs act as outstanding transducers because they provide high sensitivity in terms of resistance changes due to immunoreaction. As a result, the resistance-based biosensor reaches concentration detection as low as picomolar. The resulting paper-based biosensor is sensitive, selective and employs low-cost substrate and simple manufacturing stages. Since chemiresistors require low-power equipment and are able to detect low concentrations with inexpensive materials, the present approach may pave the way for the development of resistive biosensors at very low-cost with high performances.
authors.affiliation: Department of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Campus Sescelades, C/Marcel·lí Domingo s/n, 43007 Tarragona, Catalonia, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Pozuelo
authors.forename: Pascal
authors.initials: P
authors.lastname: Blondeau
authors.forename: Marta
authors.initials: M
authors.lastname: Novell
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Andrade
authors.forename: F
authors.initials: F
authors.lastname: Xavier Rius
authors.forename: Jordi
authors.initials: J
authors.lastname: Riu
mesh_terms: D015374:Biosensing Techniques / Q000191:economics / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010209:Paper; D014159:Transducers
chemical_list: D007074:Immunoglobulin G; D037742:Nanotubes, Carbon
keywords: Carbon nanotubes; Chemiresistor; Paper substrate; Protein detection