title: Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma.
abstract: Epithelioid hemangioendothelioma is a relatively uncommon lesion usually presenting in soft tissues. The occurrence in the mediastinum is exceptional rare. Histologically, this tumor is characterized by epithelioid cells with intracytoplasmic vacuoles in a hyalinized or mucinous stroma. Occasionally, spindle cells or osteoclast-like giant cells can be observed. Herein, we present a case of epithelioid hemangioendothelioma in a 38 year-old Chinese male. The tumor was predominantly composed of abundant spindle cells with marked atypia and scattered osteoclast-like giant cells reminiscent of malignant fibrous histiocytoma. The unusual histological appearance can pose a great diagnostic challenge. It may be easily misdiagnosed, especially if the specimen is limited or from fine-needle aspiration.
authors.forename: Xiao-Man
authors.initials: XM
authors.lastname: Li
authors.forename: Xu-Yong
authors.initials: XY
authors.lastname: Lin
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Xu
authors.forename: Juan-Han
authors.initials: JH
authors.lastname: Yu
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Chui-Feng
authors.initials: CF
authors.lastname: Fan
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: En-Hua
authors.initials: EH
authors.lastname: Wang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D017024:Chemotherapy, Adjuvant; D003937:Diagnosis, Differential; D015726:Giant Cells / Q000737:chemistry / Q000473:pathology*; D018323:Hemangioendothelioma, Epithelioid / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D051677:Histiocytoma, Malignant Fibrous / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008479:Mediastinal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D010010:Osteoclasts / Q000737:chemistry / Q000473:pathology*; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor