title: SALL4 is a marker of the embryonal subtype of hepatoblastoma.
abstract: OBJECTIVE
  SALL4 is a marker of germ cell tumours. The aim of this study was to investigate SALL4 expression in blastemal tumours, particularly in hepatoblastoma.
  
  
  RESULTS
  The study included 12 hepatoblastomas. Eight hepatoblastomas were pure epithelial tumours, and four were mixed epithelial and mesenchymal tumours. The patients were nine males and three females with a mean age of 14.6 months. Immunohistochemistry was performed with an antibody against SALL4, using an automated immunostainer. Seven of 12 hepatoblastomas showed nuclear staining only in the embryonal component. Fetal and mesenchymal components were negative.
  
  
  CONCLUSIONS
  SALL4 is expressed in blastemal tumours, particularly in the embryonal subtype of hepatoblastoma. Pathologists need to be aware of such expression so that misdiagnosis can be avoided.
authors.affiliation: Department of Pathology, University Hospital, CHRU, Lille, France; University Lille Nord de France, Lille, France.
authors.forename: Viviane
authors.initials: V
authors.lastname: Gnemmi
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Leteurtre
authors.forename: Hélène
authors.initials: H
authors.lastname: Sudour-Bonnange
authors.forename: Louise
authors.initials: L
authors.lastname: Devisme
authors.forename: Catherine
authors.initials: C
authors.lastname: Guettier
authors.forename: David
authors.initials: D
authors.lastname: Buob
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D005333:Fetus / Q000378:metabolism; D018197:Hepatoblastoma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008099:Liver / Q000196:embryology / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C472575:SALL4 protein, human; D014157:Transcription Factors
keywords: SALL4; hepatoblastoma; immunohistochemistry; nephroblastoma; yolk sac tumour