title: Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics.
abstract: The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Mu
authors.forename: Zhangqi
authors.initials: Z
authors.lastname: Shen
authors.forename: Byeonghwa
authors.initials: B
authors.lastname: Jeon
authors.forename: Lei
authors.initials: L
authors.lastname: Dai
authors.forename: Qijing
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D016123:Campylobacter jejuni / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D002939:Ciprofloxacin / Q000494:pharmacology*; D003470:Culture Media; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects / Q000235:genetics; D004357:Drug Synergism; D004917:Erythromycin / Q000494:pharmacology*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D006801:Humans; D020135:Peptide Nucleic Acids / Q000494:pharmacology*
chemical_list: D018528:ATP-Binding Cassette Transporters; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003470:Culture Media; D020135:Peptide Nucleic Acids; D002939:Ciprofloxacin; D004917:Erythromycin