title: Ech1 is a potent suppressor of lymphatic metastasis in hepatocarcinoma.
abstract: We have previously demonstrated that Ech1 is involved in the lymphatic metastasis of tumors in vitro. Here, we gain an insight into the role that Ech1 is playing in Hca-F cell. The expression of Annexin A7, Gelsolin and Clic1 genes, which were also relevant to tumor lymphatic metastasis, had been inhibited due to downregulation Ech1 gene by Western blot analysis. And downregulated of Ech1 inhibits the metastasic capability of Hca-F cells to peripheral lymph nodes in vivo. Our work indicates although the involvement of Ech1 in tumor metastasis development and progression, but the subcellular location of Ech1 has not much contribution to that.
authors.affiliation: Department of Pathology, Dalian Medical University, Key Laboratory of Tumor Metastasis of Liaoning Province University, 9, West Lvshun Southern Road, Dalian, 116044 Liaoning, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Mingzhong
authors.initials: M
authors.lastname: Sun
authors.forename: Rongkuan
authors.initials: R
authors.lastname: Li
authors.forename: Shuqing
authors.initials: S
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Mao
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Huang
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Hou
authors.forename: Mohammed Mohammed
authors.initials: MM
authors.lastname: Ibrahim
authors.forename: Jianwu
authors.initials: J
authors.lastname: Tang
mesh_terms: D000818:Animals; D017310:Annexin A7 / Q000096:biosynthesis; D019748:Carbon-Carbon Double Bond Isomerases / Q000378:metabolism*; D045744:Cell Line, Tumor; D018118:Chloride Channels / Q000096:biosynthesis; D015536:Down-Regulation; D018260:Gelsolin / Q000096:biosynthesis; D015972:Gene Expression Regulation, Neoplastic; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology / Q000517:prevention & control*; D051379:Mice
chemical_list: D017310:Annexin A7; C501966:CLIC1 protein, human; D018118:Chloride Channels; D018260:Gelsolin; D019748:Carbon-Carbon Double Bond Isomerases; C085575:delta(3,5),delta(2,4)-dienoyl-CoA isomerase
keywords: Enoyl coenzyme A hydratase 1 (Ech1); Hepatocarcinoma; Lymphatic metastasis; Subcellular location