title: Phenolic components from Rhus parviflora fruits and their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.
abstract: Nine phenolic compounds, phloracetophenone-4-O-β-D-glucopyranoside (1), p-hydroxybenzoic acid-4-O-β-D-glucopyranoside (2), leonuriside A (3), 3-methoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside (4), cis-p-coumaric acid-4-O-β-D-glucopyranoside (5), trans-p-coumaric acid-4-O-β-D-glucopyranoside (6), trans-p-coumaric acid-9-O-β-D-glucopyranoside (7), (-)-shikimic acid (8) and (-)-methyl shikimate (9), were isolated for the first time from the fruits of Rhus parviflora. Compounds 1, 3-6 and 8 inhibited lipopolysaccharide-stimulated nitric oxide (NO) production and inducible NO synthase expression in RAW 264.7 macrophages with IC50 values of 9.24 ± 1.20, 21.37 ± 2.02, 23.07 ± 1.58, 9.86 ± 0.98, 19.05 ± 1.66 and 11.3 ± 1.54 μM, respectively. The results indicated possible use of compounds for the treatment of inflammatory diseases.
authors.affiliation: a Graduate School of Biotechnology, Institute of Life Sciences and Resources , Kyung Hee University , Yongin , 446-701 , Republic of Korea.
authors.forename: Sabina
authors.initials: S
authors.lastname: Shrestha
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Lee
authors.forename: Ji-Hae
authors.initials: JH
authors.lastname: Park
authors.forename: Jin-Gyeong
authors.initials: JG
authors.lastname: Cho
authors.forename: Dong-Sung
authors.initials: DS
authors.lastname: Lee
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Youn-Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Geum-Soog
authors.initials: GS
authors.lastname: Kim
authors.forename: Myun-Ho
authors.initials: MH
authors.lastname: Bang
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
mesh_terms: D000818:Animals; D002460:Cell Line; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D010936:Plant Extracts / Q000494:pharmacology*; D029045:Rhus / Q000737:chemistry*
chemical_list: D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide