title: Exposure to zinc oxide nanoparticles affects reproductive development and biodistribution in offspring rats.
abstract: Understanding reproductive development effects and transferable properties to next generation of zinc oxide nanoparticles is necessary for prevention of its potential risks. To accomplish this, rats were exposed to zinc oxide nanomaterials (500 mg/kg bw) of less than 100 nm beginning 2 weeks before mating to postnatal day 4. In addition, body distribution of zinc concentration was evaluated in dams and offspring. Rat treated with nano-zinc oxide showed reduced number of born/live pups, decreased body weights of pups and increased fetal resorption. Zinc oxide nanomaterials were also distributed to organs such as mammary tissue of dams and liver and kidney of pups. These results indicate that zinc oxide nanoparticles-exposure before and during pregnancy and lactation could pose health risks to pregnant women and their fetus.
authors.affiliation: Environmental Health Research Department, National Institute of Environmental Research, Korea. ehjo@hotmail.com
authors.forename: Eunhye
authors.initials: E
authors.lastname: Jo
authors.forename: Gyounbaek
authors.initials: G
authors.lastname: Seo
authors.forename: Jung-Taek
authors.initials: JT
authors.lastname: Kwon
authors.forename: Mimi
authors.initials: M
authors.lastname: Lee
authors.forename: Byoung cheun
authors.initials: Bc
authors.lastname: Lee
authors.forename: Igchun
authors.initials: I
authors.lastname: Eom
authors.forename: Philje
authors.initials: P
authors.lastname: Kim
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Choi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D005327:Fetal Resorption / Q000139:chemically induced; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D053768:Metal Nanoparticles / Q000633:toxicity*; D010316:Particle Size; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects*; D013047:Specific Pathogen-Free Organisms; D014018:Tissue Distribution; D015034:Zinc Oxide / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity*
chemical_list: D015034:Zinc Oxide