title: Cross-sectional relatedness between sentences in breast radiology reports: development of an SVM classifier and evaluation against annotations of five breast radiologists.
abstract: Introduce the notion of cross-sectional relatedness as an informational dependence relation between sentences in the conclusion section of a breast radiology report and sentences in the findings section of the same report. Assess inter-rater agreement of breast radiologists. Develop and evaluate a support vector machine (SVM) classifier for automatically detecting cross-sectional relatedness. A standard reference is manually created from 444 breast radiology reports by the first author. A subset of 37 reports is annotated by five breast radiologists. Inter-rater agreement is computed among their annotations and standard reference. Thirteen numerical features are developed to characterize pairs of sentences; the optimal feature set is sought through forward selection. Inter-rater agreement is F-measure 0.623. SVM classifier has F-measure of 0.699 in the 12-fold cross-validation protocol against standard reference. Report length does not correlate with the classifier's performance (correlation coefficient = -0.073). SVM classifier has average F-measure of 0.505 against annotations by breast radiologists. Mediocre inter-rater agreement is possibly caused by: (1) definition is insufficiently actionable, (2) fine-grained nature of cross-sectional relatedness on sentence level, instead of, for instance, on paragraph level, and (3) higher-than-average complexity of 37-report sample. SVM classifier performs better against standard reference than against breast radiologists's annotations. This is supportive of (3). SVM's performance on standard reference is satisfactory. Since optimal feature set is not breast specific, results may transfer to non-breast anatomies. Applications include a smart report viewing environment and data mining.
authors.affiliation: Clinical Informatics, Interventional and Translational Solutions, Philips Research North America, 345 Scarborough Road, Briarcliff Manor, NY, 10510, USA, merlijn.sevenster@philips.com.
authors.forename: Merlijn
authors.initials: M
authors.lastname: Sevenster
authors.forename: Yuechen
authors.initials: Y
authors.lastname: Qian
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Abe
authors.forename: Johannes
authors.initials: J
authors.lastname: Buurman
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis; D005260:Female; D006801:Humans; D016247:Information Storage and Retrieval / Q000706:statistics & numerical data*; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008327:Mammography / Q000706:statistics & numerical data*; D008499:Medical Records / Q000706:statistics & numerical data*; D015588:Observer Variation; D011873:Radiology Information Systems / Q000706:statistics & numerical data*; D060388:Support Vector Machine; D016217:Ultrasonography, Mammary / Q000706:statistics & numerical data*