title: Regulation of DC development and DC-mediated T-cell immunity via CISH.
abstract: Cytokine inducible SH2-containing protein (CISH) plays a crucial role in type 1 dendritic cell (DC) development as well as in the DC-mediated activation of cytotoxic T lymphocytes (CTLs). CISH expression at late DC developmental stages shuts down the proliferation of DC progenitors by negatively regulating signal transducer and activator of transcription 5 (STAT5) and facilitates the differentiation of DCs into potent stimulators of CTLs.
authors.affiliation: Department of Biological Sciences; Sungkyunkwan University; Suwon, Gyeonggi-do, South Korea ; Department of Physiology; Bangladesh Agricultural University; Mymensingh, Bangladesh.
authors.forename: Mohammad Alam
authors.initials: MA
authors.lastname: Miah
authors.forename: Yong-Soo
authors.initials: YS
authors.lastname: Bae
keywords: CISH; CTL activation; STAT5