title: New lipoxygenase inhibitory sphingolipids from Chrozophora plicata.
abstract: Two new sphingolipids plicatin A [(2S,3S,4R)-2-{[(2R)-2-hydroxyoctdecanoyl]amino}hexaeicosane-1,3,4-triol (1)] and plicatin B [(2S,3S,4R,10E)-2-{[(2R)-2-hydroxyoctdecanoyl]amino}tricont-10-ene-1,3,4-triol (2)], together with 4-hydroxybenzaldehyde, scopoletin, uracil, and dl-threonolactone were isolated from the methanolic extract of the whole plant of Chrozophora plicata. The structures of these compounds were established using 1D ((1)H, (13)C) and 2D NMR (HMQC, HMBC, and COSY) spectroscopy and mass spectrometry (EI-MS and HR-EI-MS) and in comparison with the reported data in the literature. Compounds 1 and 2 showed inhibitory potential against enzyme lipoxygenase with IC50 values 195.1 and 102.3 μM, respectively.
authors.affiliation: a Department of Chemistry , The Islamia University of Bahawalpur, Baghdad-ul-Jadeed Campus , Bahawalpur , 63100 , Pakistan.
authors.forename: Naheed
authors.initials: N
authors.lastname: Riaz
authors.forename: Asia
authors.initials: A
authors.lastname: Tabussum
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saleem
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Romana
authors.initials: R
authors.lastname: Nasar
authors.forename: Bushra
authors.initials: B
authors.lastname: Jabeen
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabbar
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry / Q000302:isolation & purification; D019665:Euphorbiaceae / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D013107:Sphingolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D001547:Benzaldehydes; D016859:Lipoxygenase Inhibitors; D013107:Sphingolipids; C585990:plicatin A; C585992:plicatin B sphingolipid; C011483:4-hydroxybenzaldehyde