title: [Cerebral toxoplasmosis in the pattern of secondary CNS involvements in HIV-infected patients in the Russian federation: clinical and diagnostic features].
abstract: The incidence of cerebral toxoplasmosis (CT) among all brain involvements was determined in patients with Stage 4B HIV infection (AIDS) in 2003-2009. Clinical and laboratory parameters were estimated in 156 patients to reveal diagnostic criteria. As a result, CT was shown to be a leading cause of neurologic diseases in patients with late-stage HIV infection (34.7% of cases of brain involvement). In 11.5%, it took place as a generalized process. CT concurrent with cytomegalovirus infection, tuberculosis, or other secondary lesions was frequently diagnosed. Of importance in the diagnosis of CT are magnetic resonance imaging results in addition to basic, clinical data that can assume this diagnosis. The high and moderate serum concentrations of T.gondii IgG are of diagnostic value, which may be used as an auxiliary method to verify the diagnosis.
authors.forename: T N
authors.initials: TN
authors.lastname: Ermak
authors.forename: A B
authors.initials: AB
authors.lastname: Peregudova
authors.forename: V I
authors.initials: VI
authors.lastname: Shakhgil'dian
authors.forename: D B
authors.initials: DB
authors.lastname: Goncharov
mesh_terms: D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood*; D001921:Brain / Q000382:microbiology / Q000469:parasitology / Q000473:pathology* / Q000821:virology; D060085:Coinfection; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D018450:Disease Progression; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D012426:Russia / Q000453:epidemiology; D014122:Toxoplasma / Q000302:isolation & purification; D016781:Toxoplasmosis, Cerebral / Q000097:blood / Q000453:epidemiology / Q000469:parasitology / Q000473:pathology*; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G