title: Reduced postmovement cortical inhibition in patients with paroxysmal kinesigenic dyskinesia.
abstract: OBJECTIVE
  To characterize movement-related neural oscillatory activity and to clarify its neurophysiologic role in paroxysmal kinesigenic dyskinesia (PKD).
  
  
  METHODS
  We recorded neuromagnetic event-related desynchronization (ERD) and event-related synchronization (ERS) activities in response to a self-paced finger-lifting task in 16 patients with PKD and 17 healthy controls.
  
  
  RESULTS
  The amplitude of α-ERD was comparable between the healthy controls and patients with PKD, whereas either the contralateral or ipsilateral β-ERS was decreased. The peak latency of contralateral β-ERS was delayed in patients with PKD. Patients with less frequent dyskinetic attacks demonstrated a larger ipsilateral β-ERS. Moreover, some patients with PKD revealed a lesser degree of contralateral preponderance of β-ERS generation.
  
  
  CONCLUSIONS
  The present data imply a decreased postmovement inhibition of motor cortex in patients with PKD, and the inhibitory function in the contralateral hemisphere is more affected than that in the ipsilateral hemisphere.
authors.affiliation: Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Wan-Yu
authors.initials: WY
authors.lastname: Hsu
authors.forename: Kwong-Kum
authors.initials: KK
authors.lastname: Liao
authors.forename: Yi-Jhan
authors.initials: YJ
authors.lastname: Tseng
authors.forename: Shang-Yeong
authors.initials: SY
authors.lastname: Kwan
authors.forename: Rou-Shayn
authors.initials: RS
authors.lastname: Chen
authors.forename: Yung-Yang
authors.initials: YY
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002819:Chorea / Q000503:physiopathology*; D003344:Cortical Synchronization / Q000502:physiology*; D004421:Dystonia; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009433:Neural Inhibition / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult