title: [The 8-OH-2-desoxiguanosin marker of oxidizing modification of DNA in patients with diffused dermatitis].
abstract: The level of 8-OH-2-desoxiguanosin in blood serum of patients with severe chronic dermatitis was analyzed. It is demonstrated that in comparison with healthy patients in examined group of patients this indicator is increased mainly in patients with atopic dermatitis (up to 62%) and least of all with psoriasis (up to 25%) and bullous dermatitis (up to 18%). The statistically reliable differences of this indicator from control values under endogenic intoxication and different degree of severity of disease are determined. The detection of level of 8-OH-2-desoxiguanosin in blood serum is an informative technique of analysis to increase quality of laboratory monitoring of oxidizing stress.
authors.forename: N A
authors.initials: NA
authors.lastname: Shchelchkova
authors.forename: T V
authors.initials: TV
authors.lastname: Kopytova
authors.forename: L N
authors.initials: LN
authors.lastname: Khimkina
authors.forename: G A
authors.initials: GA
authors.lastname: Panteleeva
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D004247:DNA / Q000737:chemistry / Q000502:physiology; D003876:Dermatitis, Atopic / Q000097:blood* / Q000503:physiopathology; D006151:Guanosine / Q000031:analogs & derivatives / Q000097:blood*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D015227:Lipid Peroxidation; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers; D006151:Guanosine; D007073:Immunoglobulin E; D004247:DNA