title: Paget disease of bone: diagnosis and drug therapy.
abstract: Paget disease of bone is a focal disorder of aging bone that may be asymptomatic or may present with pain, bowing deformity, fracture, or a nonspecific rheumatic complaint. It is the second most common disease of bone in the elderly after osteoporosis, and the loss of structural integrity in affected bone conveys a risk of fracture. It may occur sporadically or in geographic or familial clusters. This article discusses the prevalence, pathology, workup, and treatment of Paget disease of bone.
authors.affiliation: Department of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, USA. mseton@partners.org
authors.forename: Margaret
authors.initials: M
authors.lastname: Seton
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D014943:Global Health; D006801:Humans; D010001:Osteitis Deformans / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates