title: Multifunctional nanomicellar systems for delivering anticancer drugs.
abstract: Most anticancer drugs cause severe side effect due to the lack of selectivity for cancer cells. In recent years, new strategies of micellar systems, which design for specifically target anticancer drugs to tumors, are developed at the forefront of polymeric science. To improve efficiency of delivery and cancer specificity, considerable emphasis has been placed on the development of micellar systems with passive and active targeting. In this review article, we summarized various strategies of designing multifunctional micellar systems in the purpose of improving delivery efficiency. Micellar systems compose of a multifunctional copolymer or a mixture of two or more copolymers with different properties is a plausible approach to tuning the resulting properties and satisfied various requirements for anticancer drug delivery. It appears that multifunctional micellar systems hold great potential in cancer therapy.
authors.affiliation: Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, ROC; Department of Chemical Engineering and R&D Center for Membrane Technology, Chung Yuan Christian University, Chungli, 320, Taiwan, ROC.
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Chun-Liang
authors.initials: CL
authors.lastname: Lo
authors.forename: Ging-Ho
authors.initials: GH
authors.lastname: Hsiue
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D008823:Micelles; D011108:Polymers
keywords: cancer therapy; controlled drug delivery; micelles; stimuli responsive; tumor targeting