title: Acute kidney injury in the elderly.
abstract: Most patients who develop acute kidney injury (AKI) are older than 65 years. Specific structural and functional changes that occur in the aging kidney predispose the elderly patient to AKI. This risk is further compounded by comorbid conditions, polypharmacy, and the need for invasive procedures. When AKI does occur, it is associated with significant morbidity and mortality. Although morbidity and mortality increases with advancing age, many elderly patients can survive AKI and do well. Thus, decision making should be thoughtful and individualized, and not dependent on age. Whenever possible, preventive approaches should be pursued to lessen the burden of AKI.
authors.affiliation: Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908, USA. MHR9R@hscmail.mcc.virginia.edu
authors.forename: Mitchell H
authors.initials: MH
authors.lastname: Rosner
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D000368:Aged; D000375:Aging; D015897:Comorbidity; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007677:Kidney Function Tests / Q000379:methods; D063305:Organ Dysfunction Scores; D063868:Patient Outcome Assessment; D018579:Patient Selection; D019338:Polypharmacy; D017410:Practice Guidelines as Topic; D006435:Renal Dialysis / Q000379:methods / Q000706:statistics & numerical data; D020379:Risk Adjustment; D012307:Risk Factors
keywords: Acute kidney injury; Dialysis; Elderly; Outcome