title: Histological and mechanical properties of autologous living tissue biotubes.
abstract: The aim of this study was to explore and evaluate biotubes consisting of autologous tissues. The biotubes were prepared by intra-abdominally embedding silicon rods as moulds. The specimens were analyzed by mechanical tests, histological observation and superficial study. The intra-abdominal implantation of the silicone tubes readily stimulated the development of the biotubes. The biotubes consisted of collagen-rich extracellular matrices. Myofibroblasts appeared as elongated cells with circumferential or longitudinal orientations. Subsequent to one month of embedding, the thickness of the tube wall was 70-250μm. The burst strength was 1100±187 mmHg and the suturability was excellent. Biotubes that have the ability to be widely variable in their shapes are composed of autologous cells and glomerular extracellular matrices. Biotubes are ideal grafts for tissue engineering as they are able to avoid immunological rejection and are of sufficient mechanical strength.
authors.affiliation: Departments of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China.
authors.forename: Xiao-Song
authors.initials: XS
authors.lastname: Chen
authors.forename: Tong-Wen
authors.initials: TW
authors.lastname: Ou
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.forename: Heng-Xi
authors.initials: HX
authors.lastname: Yu
authors.forename: Yong-Quan
authors.initials: YQ
authors.lastname: Gu
authors.forename: Ye-Qing
authors.initials: YQ
authors.lastname: Cui
authors.forename: Jing-Yan
authors.initials: JY
authors.lastname: Zhang
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Xu
authors.forename: Han-Chen
authors.initials: HC
authors.lastname: Sun
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
keywords: autologous transplant; biotube; collagen; small caliber; tissue engineering