title: [Case report. Leukocytosis in the course of Clostridium difficile infection].
abstract: Clostridium difficile infections (CDI) are increasing in incidence and severity, amongst other reasons because of the increasing spread of hypervirulent strains. Leukocytosis is a sign of severe CDI and is predictive for a complicated course. In this case report, we describe 2 patients with CDI who developed leukocytosis within a leukemoid range. In both cases high white blood cell counts returned totally to normal range under CDI therapy according to guidelines. Leukemia-related therapy patterns were not needed. Notably, in none of the patients a hypervirulent strain was isolated.
authors.affiliation: Klinik für Anästhesiologieund operative Intensivmedizin, Krankenhaus Köln-Merheim. weberk@kliniken-koeln.de
authors.forename: Katja S
authors.initials: KS
authors.lastname: Weber
authors.forename: Jerome M
authors.initials: JM
authors.lastname: Defosse
authors.forename: Frank
authors.initials: F
authors.lastname: Wappler
authors.forename: Samir G
authors.initials: SG
authors.lastname: Sakka
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016360:Clostridioides difficile; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004761:Enterocolitis, Pseudomembranous / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006333:Heart Failure / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D007813:Laparotomy; D007964:Leukocytosis / Q000188:drug therapy / Q000209:etiology*; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D011379:Prognosis; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole