title: Synthesis and Properties of Disulfide-Bond Containing Eight-Membered Rings.
abstract: The cyclocystine ring structure (CRS,3), which results from a disulfide-bond between adjacent cysteine residues, is a rare motif in protein structures and is functionally important to those few proteins that posses it. This communication will focus on the construction of CRS mimics and the determination of their respective redox potentials.
authors.affiliation: Department of Biochemistry, 89 Beaumont Ave., Given Building, University of Vermont, Burlington VT 05405.
authors.forename: Erik L
authors.initials: EL
authors.lastname: Ruggles
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hondal
keywords: cyclocystine; dithiocine; thiol-disulfide redox; vicinal disulfide-bond