title: Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy.
abstract: Wnt and Rho GTPase signaling play critical roles in governing numerous aspects of cell physiology, and have been shown to be involved in endochondral ossification and osteoarthritis (OA) development. In this review, current studies of canonical Wnt signaling in OA development, together with the differential roles of Rho GTPases in chondrocyte maturation and OA pathology are critically summarized. Based on the current scientific literature together with our preliminary results, the strategy of targeting Wnt and Rho GTPase for OA prognosis and therapy is suggested, which is instructive for clinical treatment of the disease.
authors.forename: Shouan
authors.initials: S
authors.lastname: Zhu
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Boon Chin
authors.initials: BC
authors.lastname: Heng
authors.forename: Pengfei
authors.initials: P
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Hong Wei
authors.initials: HW
authors.lastname: Ouyang
mesh_terms: D000818:Animals; D019902:Chondrocytes / Q000166:cytology; D020219:Chondrogenesis / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans; D010003:Osteoarthritis / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy*; D060449:Wnt Signaling Pathway / Q000502:physiology*
chemical_list: D020558:GTP Phosphohydrolases