title: Hydrophobic core formation in protein complex of cathepsin.
abstract: The "fuzzy oil drop" model assumes that the idealized hydrophobic core in a protein body can be described by a 3D Gauss function. The structure of the 1ICF protein (cathepsin), which participates in the proteolysis process and has cysteine-type peptidase activity, has been analyzed on the basis of the "fuzzy oil drop" model. The authors have determined the contribution of individual exon fragments to the creation of a common hydrophobic core and assessed the involvement of each chain in this process, depending on the number of complexed chains. Quantitative assessment of exons, chains, dimers, and the whole complex suggest that each of these units plays a different role in shaping the protein's hydrophobic core.
authors.affiliation: a Department of Bioinformatics and Telemedicine , Medical College - Jagiellonian University , Lazarza 16 , 31-530 , Krakow , Poland .
authors.forename: Monika
authors.initials: M
authors.lastname: Piwowar
authors.forename: Mateusz
authors.initials: M
authors.lastname: Banach
authors.forename: Leszek
authors.initials: L
authors.lastname: Konieczny
authors.forename: Irena
authors.initials: I
authors.lastname: Roterman
mesh_terms: D002403:Cathepsins / Q000737:chemistry* / Q000235:genetics; D005091:Exons; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D011487:Protein Conformation; D055503:Protein Multimerization
chemical_list: D002403:Cathepsins
keywords: exon; fuzzy oil drop; hydrophobic core; hydrophobicity; oil drop model