title: [Application of vancomycin-loaded calcium sulphate in treatment of osteomyelitis].
abstract: OBJECTIVE
  To investigate the role of vancomycin-loaded calcium sulphate in the treatment of osteomyelitis.
  
  
  METHODS
  We implanted vancomycin-loaded calcium sulphate into 24 patients with traumatic osteomyelitis who were treated in our hospital from February 2008 to February 2010,and then the antibiotic concentrations in the lesions were measured.Bacterial culture results,inflammatory markers,as well as wound healing were observed.X-ray was performed in the location where the vancomycin-loaded calcium sulphate was implanted.The blood vancomycin level as well as liver and kidney functions were determined.
  
  
  RESULTS
  The vancomycin concentration in the lesion exceeded the effective therapeutic concentrations and the minimum inhibitory concentration,while the blood concentration was low.The liver and renal function remained normal.The safety profile was good,and the cure rate of osteomyelitis reached 100%.
  
  
  CONCLUSIONS
  The vancomycin-loaded calcium sulphate can release high-concentration vancomycin in the diseased sites without causing high blood concentration.Also,it can guide the regeneration of bones.Therefore,it is effective and safe in treating osteomyelitis.
authors.affiliation: Department of Orthopedics,Tongde Hospital of Zhejiang Province, Hangzhou, China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Chun
authors.initials: C
authors.lastname: Zhang
authors.forename: Qiao-feng
authors.initials: QF
authors.lastname: Guo
authors.forename: Li-feng
authors.initials: LF
authors.lastname: Shen
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001672:Biocompatible Materials; D002133:Calcium Sulfate / Q000627:therapeutic use*; D002648:Child; D004337:Drug Carriers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000628:therapy*; D014640:Vancomycin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D014640:Vancomycin; D002133:Calcium Sulfate