title: Feline immunodeficiency virus latency.
abstract: Despite highly effective anti-retroviral therapy, HIV is thought to persist in patients within long-lived cellular reservoirs in the form of a transcriptionally inactive (latent) integrated provirus. Lentiviral latency has therefore come to the forefront of the discussion on the possibility of a cure for HIV infection in humans. Animal models of lentiviral latency provide an essential tool to study mechanisms of latency and therapeutic manipulation. Of the three animal models that have been described, the feline immunodeficiency virus (FIV)-infected cat is the most recent and least characterized. However, several aspects of this model make it attractive for latency research, and it may be complementary to other model systems. This article reviews what is known about FIV latency and chronic FIV infection and how it compares with that of other lentiviruses. It thereby offers a framework for the usefulness of this model in future research aimed at lentiviral eradication.
authors.affiliation: Department of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, 4206 Vet Med 3A, Davis, CA 95616, USA. sjmcdonnel@ucdavis.edu
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: McDonnel
authors.forename: Ellen E
authors.initials: EE
authors.lastname: Sparger
authors.forename: Brian G
authors.initials: BG
authors.lastname: Murphy
mesh_terms: D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D016181:Feline Acquired Immunodeficiency Syndrome / Q000821:virology*; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000502:physiology*; D017735:Virus Latency