title: Klotho acts as a tumor suppressor in cancers.
abstract: The klotho gene is a classical "aging suppressor" gene. Its roles in the pathology of chronic kidney diseases have been well documented. However, the role of Klotho in tumorigenesis, cancer progression, and prognosis is attracting more and more attention. Recent studies have shown that Klotho participates in the progression of several types of human cancers. Klotho functions as a tumor suppressor by inhibiting insulin/IGF1, p53/p21, and Wnt signaling. Silencing klotho gene expression is mainly mediated through promoter hypermethylation and histone deacetylation in cancer. Klotho has been proposed to take part in cell proliferation, survival, autophagy, and resistance to anti-cancer therapies.
authors.affiliation: Department of General Surgery, 8th Changsha Hospital, Changsha, Hunan, 410015, People's Republic of China.
authors.forename: Biao
authors.initials: B
authors.lastname: Xie
authors.forename: Jinhui
authors.initials: J
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Junkun
authors.initials: J
authors.lastname: Zhan
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics; D016147:Genes, Tumor Suppressor; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D000090265:Klotho Proteins; D051379:Mice; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D005966:Glucuronidase; D000090265:Klotho Proteins