title: Predictive models for type 2 diabetes onset in middle-aged subjects with the metabolic syndrome.
abstract: OBJECTIVE
  To investigate the predictive value of different biomarkers for the incidence of type 2 diabetes mellitus (T2DM) in subjects with metabolic syndrome.
  
  
  METHODS
  A prospective study of 525 non-diabetic, middle-aged Lithuanian men and women with metabolic syndrome but without overt atherosclerotic diseases during a follow-up period of two to four years. We used logistic regression to develop predictive models for incident cases and to investigate the association between various markers and the onset of T2DM.
  
  
  RESULTS
  Fasting plasma glucose (FPG), body mass index (BMI), and glycosylated haemoglobin can be used to predict diabetes onset with a high level of accuracy and each was shown to have a cumulative predictive value. The estimated area under the receiver-operating characteristic curve (AUC) for this combination was 0.92. The oral glucose tolerance test (OGTT) did not show cumulative predictive value. Additionally, progression to diabetes was associated with high values of aortic pulse-wave velocity (aPWV).
  
  
  CONCLUSIONS
  T2DM onset in middle-aged metabolic syndrome subjects can be predicted with remarkable accuracy using the combination of FPG, BMI, and HbA1c, and is related to elevated aPWV measurements.
authors.affiliation: Machine Learning and Data Mining group, IBM Research - Haifa, Mount Carmel, Haifa 3498825, Israel. ozery@il.ibm.com.
authors.forename: Michal
authors.initials: M
authors.lastname: Ozery-Flato
authors.forename: Naama
authors.initials: N
authors.lastname: Parush
authors.forename: Tal
authors.initials: T
authors.lastname: El-Hay
authors.forename: Zydrūnė
authors.initials: Z
authors.lastname: Visockienė
authors.forename: Ligita
authors.initials: L
authors.lastname: Ryliškytė
authors.forename: Jolita
authors.initials: J
authors.lastname: Badarienė
authors.forename: Svetlana
authors.initials: S
authors.lastname: Solovjova
authors.forename: Milda
authors.initials: M
authors.lastname: Kovaitė
authors.forename: Rokas
authors.initials: R
authors.lastname: Navickas
authors.forename: Aleksandras
authors.initials: A
authors.lastname: Laucevičius