title: Cognition and gait show a distinct pattern of association in the general population.
abstract: BACKGROUND
  With brain aging, cognition and gait deteriorate in several domains. However, the interrelationship between cognitive and gait domains remains unclear. We investigated the independent associations between cognitive and gait domains in a community-dwelling population.
  
  
  METHODS
  In the Rotterdam Study, 1232 participants underwent cognitive and gait assessment. Cognitive assessment included memory, information processing speed, fine motor speed, and executive function. Gait was summarized into seven independent domains: Rhythm, Variability, Phases, Pace, Tandem, Turning, and Base of Support. With multivariate linear regression, independent associations between cognitive and gait domains were investigated.
  
  
  RESULTS
  Information processing speed associated with Rhythm, fine motor speed with Tandem, and executive function with Pace. The effect sizes corresponded to a 5- to 10-year deterioration in gait.
  
  
  CONCLUSIONS
  Cognition and gait show a distinct pattern of association. These data accentuate the close, but complicated, relation between cognition and gait, and they may aid in unraveling the broader spectrum of the effects of brain aging.
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Vincentius J A
authors.initials: VJ
authors.lastname: Verlinden
authors.affiliation: Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Jos N
authors.initials: JN
authors.lastname: van der Geest
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: m.a.ikram@erasmusmc.nl.
authors.forename: M Arfan
authors.initials: MA
authors.lastname: Ikram
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology* / Q000523:psychology*; D001696:Biomechanical Phenomena; D003071:Cognition; D003430:Cross-Sectional Studies; D056344:Executive Function; D005260:Female; D005500:Follow-Up Studies; D005684:Gait; D006801:Humans; D016014:Linear Models; D008297:Male; D009048:Motor Skills; D015999:Multivariate Analysis; D009426:Netherlands; D011446:Prospective Studies; D011581:Psychological Tests
keywords: Cognition; Cognitive impairment; Epidemiology; Gait; Walking