title: Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China.
abstract: BACKGROUND
  Genome-wide association studies (GWAS) have identified numerous single-nucleotide polymorphisms (SNPs) that can modulate the risk of developing Parkinson's disease (PD).
  
  
  METHODS
  We investigated the association of previously identified loci in a Mainland Chinese population to identify a possible ethnic-specific effect with GWAS analysis. Seventeen SNPs were genotyped from those loci using case-control methodology to analyze a total of 1,737 individuals.
  
  
  RESULTS
  Strong evidence of an association for reference SNP 894278 (rs894278) and rs11931074 on 4q22 throughout the α synuclein (SNCA) region was observed in our study. The SNP rs894278 confers risk via a dominant model and an additive model, whereas the minor allele G of rs11931074 reduces the risk of PD progression. The minor allele frequency of rs11724635 produced weaker signals for PD, but this was not replicated in the genotype after adjusting for age and sex.
  
  
  CONCLUSIONS
  This study yields new clues about GWAS-linked data in patients with PD from Mainland China.
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiao
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Yu-Yan
authors.initials: YY
authors.lastname: Tan
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Ma
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D002681:China; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D051844:alpha-Synuclein; D036541:ADP-ribosyl Cyclase; C087521:ADP-ribosyl cyclase 2
keywords: BST1; Parkinson's disease; SNCA; single nucleotide polymorphism