title: Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster.
abstract: Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities against the lesions induced by mitomycin C (MMC) and doxorrubicin (DXR) using the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. Three-day-old larvae, trans-heterozygous for two genetic markers (mwh and flr3 ), were co-treated with TNJ plus MMC or DXR. We have observed a reduction in genotoxic effects of MMC and DXR caused by the juice. TNJ provoked a marked decrease in all kinds of MMC- and DXR-induced mutant spots, mainly due to its antirecombinagenic activity. The TNJ protective effects were concentration-dependent, indicating a dose-response correlation, that can be attributed to a powerful antioxidant and/or free radical scavenger ability of TNJ.
authors.affiliation: Laboratório de Genética Toxicológica, Departamento de Bioquímica e Biologia Molecular, ICB, Universidade Federal de Goiás/UFG, Goiânia, GO, Brasil.
authors.forename: Leonardo P
authors.initials: LP
authors.lastname: Franchi
authors.forename: Nilza N
authors.initials: NN
authors.lastname: Guimarães
authors.forename: Laise R
authors.initials: LR
authors.lastname: De Andrade
authors.forename: Heloísa H R
authors.initials: HH
authors.lastname: De Andrade
authors.forename: Maurício
authors.initials: M
authors.lastname: Lehmann
authors.forename: Rafael R
authors.initials: RR
authors.lastname: Dihl
authors.forename: Kênya S
authors.initials: KS
authors.lastname: Cunha
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001628:Beverages; D004249:DNA Damage / Q000187:drug effects; D004331:Drosophila melanogaster / Q000166:cytology / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D016685:Mitomycin / Q000494:pharmacology; D032066:Morinda / Q000737:chemistry*; D009152:Mutagenicity Tests / Q000379:methods*; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D016587:Antimutagenic Agents; D016685:Mitomycin; D013806:Theophylline; C029797:doxofylline