title: [MicroRNAs and nonresolving inflammation-related cancer].
abstract: The link between nonresolving inflammation and cancer is well documented. On the one hand, epidemiologic evidence supports that approximately 25% of all human cancer worldwide is caused by nonresolving inflammation. On the other hand, inflammatory cells are found in the microenvironment of most, if not all, tumors. In the tumor micro-environment, inflammatory cells and molecules influence almost every aspect of cancer. MicroRNAs (miRNAs) participate in the initiation and progression of nonresolving inflammation-related cancer by regulating the key genes and related signaling pathways. Further investigation into the molecular mechanisms by which miRNAs carry out their functions will be of great value in the prevention, early diagnosis, and treatment of tumors.
authors.affiliation: Central South University, Changsha, China.
authors.forename: Zhaojian
authors.initials: Z
authors.lastname: Gong
authors.forename: Shanshan
authors.initials: S
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Tang
authors.forename: Xiayu
authors.initials: X
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Xiang
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Xiang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Zeng
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: Guiyuan
authors.initials: G
authors.lastname: Li
mesh_terms: D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000235:genetics* / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics*; D059016:Tumor Microenvironment
chemical_list: D018836:Inflammation Mediators; D035683:MicroRNAs