title: Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors.
abstract: OBJECTIVE
  To analyze the reproductive outcome of recipients of donated ova according to their body mass index (BMI).
  
  
  METHODS
  Twelve-year retrospective cohort analysis.
  
  
  METHODS
  Fertility clinics.
  
  
  METHODS
  9,587 first cycles of ovum donation with ova from normoweight donors.
  
  
  METHODS
  Recipients divided according to their BMI to analyze IVF laboratory and outcome parameters: lean with BMI <20 kg/m(2) (n = 1,458; 15.2%); normoweight with BMI 20-24.9 kg/m(2) (n = 5,706; 59.5%), overweight with BMI 25-29.9 kg/m(2) (n = 1,770; 18.5%), and obese with BMI ≥30 kg/m(2) (n = 653; 6.8%).
  
  
  METHODS
  Implantation, biochemical and clinical pregnancy, miscarriage, and live-birth rates.
  
  
  RESULTS
  In vitro fertilization laboratory parameters did not differ according to BMI. However, implantation, pregnancy, clinical pregnancy, twin pregnancy, and live-birth rates were significantly reduced as BMI increased. In the lean, normoweight, overweight, and obese groups, the implantation rate was 40.4%, 39.9%, 38.5%, and 30.9%, clinical pregnancy rate was 56.9%, 55.9%, 54.3%, and 45.3%, and live-birth rate was 38.6%, 37.9%, 34.9%, and 27.7%, respectively. However, clinical miscarriage rates were similar in all the groups.
  
  
  CONCLUSIONS
  Female obesity impairs the reproductive outcome of ovum donation probably as a result of reduced uterine receptivity.
authors.affiliation: Instituto Valenciano de Infertilidad, University of Valencia, Valencia, Spain. Electronic address: Jose.Bellver@ivi.es.
authors.forename: José
authors.initials: J
authors.lastname: Bellver
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellicer
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: García-Velasco
authors.forename: Agustín
authors.initials: A
authors.lastname: Ballesteros
authors.forename: José
authors.initials: J
authors.lastname: Remohí
authors.forename: Marcos
authors.initials: M
authors.lastname: Meseguer
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D000704:Analysis of Variance; D015992:Body Mass Index; D001835:Body Weight; D016009:Chi-Square Distribution; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D016015:Logistic Models; D009765:Obesity / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D016017:Odds Ratio; D018587:Oocyte Donation / Q000009:adverse effects; D011247:Pregnancy; D018873:Pregnancy Rate; D059285:Pregnancy, Twin; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain; D014019:Tissue Donors; D016896:Treatment Outcome; D014599:Uterus / Q000503:physiopathology*
keywords: Female obesity; live birth; ovum donation; pregnancy; uterus