title: A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells.
abstract: We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug is able to monitor drug delivery and cellular imaging.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea.
authors.forename: Sankarprasad
authors.initials: S
authors.lastname: Bhuniya
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Lee
authors.forename: Hyun Mi
authors.initials: HM
authors.lastname: Jeon
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Han
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Lee
authors.forename: Nayoung
authors.initials: N
authors.lastname: Park
authors.forename: Sukhendu
authors.initials: S
authors.lastname: Maiti
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D045744:Cell Line, Tumor; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000378:metabolism; D016503:Drug Delivery Systems; D016903:Drug Monitoring; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D018613:Microscopy, Confocal; D015394:Molecular Structure; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry*; D000093542:Gemcitabine
chemical_list: D005456:Fluorescent Dyes; D011355:Prodrugs; D003841:Deoxycytidine; D000093542:Gemcitabine