title: Aging, the central nervous system, and mobility.
abstract: BACKGROUND
  Mobility limitations are common and hazardous in community-dwelling older adults but are largely understudied, particularly regarding the role of the central nervous system (CNS). This has limited development of clearly defined pathophysiology, clinical terminology, and effective treatments. Understanding how changes in the CNS contribute to mobility limitations has the potential to inform future intervention studies.
  
  
  METHODS
  A conference series was launched at the 2012 conference of the Gerontological Society of America in collaboration with the National Institute on Aging and the University of Pittsburgh. The overarching goal of the conference series is to facilitate the translation of research results into interventions that improve mobility for older adults.
  
  
  RESULTS
  Evidence from basic, clinical, and epidemiological studies supports the CNS as an important contributor to mobility limitations in older adults without overt neurologic disease. Three main goals for future work that emerged were as follows: (a) develop models of mobility limitations in older adults that differentiate aging from disease-related processes and that fully integrate CNS with musculoskeletal contributors; (b) quantify the contribution of the CNS to mobility loss in older adults in the absence of overt neurologic diseases; (c) promote cross-disciplinary collaboration to generate new ideas and address current methodological issues and barriers, including real-world mobility measures and life-course approaches.
  
  
  CONCLUSIONS
  In addition to greater cross-disciplinary research, there is a need for new approaches to training clinicians and investigators, which integrate concepts and methodologies from individual disciplines, focus on emerging methodologies, and prepare investigators to assess complex, multisystem associations.
authors.affiliation: Center for Aging and Population Health, Graduate School of Public Health, 130 North Bellefield Street, Room 507, Pittsburgh, PA 15213. rosanoc@edc.pitt.edu.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Rosso
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Studenski
authors.forename: Wen G
authors.initials: WG
authors.lastname: Chen
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Aizenstein
authors.forename: Neil B
authors.initials: NB
authors.lastname: Alexander
authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Black
authors.forename: Richard
authors.initials: R
authors.lastname: Camicioli
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Carlson
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Hausdorff
authors.forename: Jeff
authors.initials: J
authors.lastname: Kaye
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
authors.forename: Lewis A
authors.initials: LA
authors.lastname: Lipsitz
authors.forename: Joe
authors.initials: J
authors.lastname: Verghese
authors.forename: Caterina
authors.initials: C
authors.lastname: Rosano
mesh_terms: D000375:Aging / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D005684:Gait / Q000502:physiology; D006801:Humans; D051346:Mobility Limitation
keywords: Central nervous system; Mobility.; Motor control