title: Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds.
abstract: A series of novel hybrid compounds between dibenzo[b,d]furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring, and the substitution of the imidazolyl-3-position with a naphthylacyl or 4-methoxyphenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 60 was found to be the most potent derivatives against all of human tumor cell lines investigated, while compound 49 was found to be more selective against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721). Compound 60 can induce the G1 phase cell cycle arrest and apoptosis in SMMC-7721 cells.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
authors.forename: Lan-Xiang
authors.initials: LX
authors.lastname: Liu
authors.forename: Xue-Quan
authors.initials: XQ
authors.lastname: Wang
authors.forename: Ju-Ming
authors.initials: JM
authors.lastname: Yan
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Sun
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Bei
authors.initials: B
authors.lastname: Zhou
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Zhang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D059585:G1 Phase Cell Cycle Checkpoints / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles
keywords: Antitumor activities; Dibenzo[b,d]furan; Hybrid compound; Imidazole; Structure–activity relationships