title: Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects.
abstract: It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ± 10 years) with a wide range of BMI (24.6-31.0 kg/m(2)). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p < 0.05) and lower 2-h glucose concentrations during OGTT (r = -0.31; p < 0.05). In addition, fasting (r = -0.36; p < 0.05) and 2-h glucose concentrations were negatively related to circulating levels of soluble receptor for AGE (RAGE) isoforms (r = -0.39; p < 0.01). In conclusion, in healthy humans, we show a cross-sectional association between advanced glycation end products and acute insulin secretion during glucose tolerance testing.
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia, jforbes@mmri.mater.org.au.
authors.forename: Josephine M
authors.initials: JM
authors.lastname: Forbes
authors.forename: Karly C
authors.initials: KC
authors.lastname: Sourris
authors.forename: Maximilian P J
authors.initials: MP
authors.lastname: de Courten
authors.forename: Sonia L
authors.initials: SL
authors.lastname: Dougherty
authors.forename: Vibhasha
authors.initials: V
authors.lastname: Chand
authors.forename: Jasmine G
authors.initials: JG
authors.lastname: Lyons
authors.forename: David
authors.initials: D
authors.lastname: Bertovic
authors.forename: Melinda T
authors.initials: MT
authors.lastname: Coughlan
authors.forename: Markus P
authors.initials: MP
authors.lastname: Schlaich
authors.forename: Georgia
authors.initials: G
authors.lastname: Soldatos
authors.forename: Mark E
authors.initials: ME
authors.lastname: Cooper
authors.forename: Nora E
authors.initials: NE
authors.lastname: Straznicky
authors.forename: Bronwyn A
authors.initials: BA
authors.lastname: Kingwell
authors.forename: Barbora
authors.initials: B
authors.lastname: de Courten
mesh_terms: D000328:Adult; D001786:Blood Glucose; D003430:Cross-Sectional Studies; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D007328:Insulin; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic