title: Interleukin-6 concentration changes in plasma and saliva in bisphosphonate-related osteonecrosis of the jaws.
abstract: OBJECTIVE
  To determine the plasma and saliva levels of IL-6 in patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) and to investigate whether there is a correlation between more advanced stages of BRONJ and levels of IL-6.
  
  
  METHODS
  We studied three groups: group 1 consisted of 30 patients with BRONJ due to intravenous bisphosphonates (ivBP), group 2 consisted of 25 patients treated with ivBP but without BRONJ, and group 3 consisted of 15 healthy controls. In each case, we assayed plasma and saliva IL-6 samples using an ELISA test.
  
  
  RESULTS
  Significantly, higher IL-6 values were found in both saliva and plasma in group 1 vs groups 2 and 3 (P < 0.01). Group 1 showed no differences in plasma or saliva IL-6 according to patient gender (P > 0.05), type of tumor, BRONJ location, etiology of BRONJ, or disease stage (P > 0.05). We found higher plasma and saliva IL-6 values in the more advances stages of BRONJ, although the differences were not statistically significant.
  
  
  CONCLUSIONS
  Plasma and saliva IL-6 values were higher in our patients with BRONJ than in controls and therefore might be a useful tool for monitoring the severity of BRONJ.
authors.affiliation: Oral Medicine, Head Service of Stomatology and Maxillofacial Surgery, University of Valencia, University General Hospital, Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Bagan
authors.forename: G T
authors.initials: GT
authors.lastname: Sáez
authors.forename: M C
authors.initials: MC
authors.lastname: Tormos
authors.forename: E
authors.initials: E
authors.lastname: Hens
authors.forename: M J
authors.initials: MJ
authors.lastname: Terol
authors.forename: L
authors.initials: L
authors.lastname: Bagan
authors.forename: J M
authors.initials: JM
authors.lastname: Diaz-Fernández
authors.forename: A
authors.initials: A
authors.lastname: Lluch
authors.forename: C
authors.initials: C
authors.lastname: Camps
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000097:blood / Q000378:metabolism*; D004164:Diphosphonates / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis* / Q000097:blood*; D008297:Male; D012463:Saliva / Q000737:chemistry*
chemical_list: D004164:Diphosphonates; C508600:IL6 protein, human; D015850:Interleukin-6
keywords: bisphosphonates; interleukin-6; osteonecrosis of the jaws