title: Faecalibacterium prausnitzii and human intestinal health.
abstract: Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.
authors.affiliation: INRA, Commensal and Probiotics-Host Interactions Laboratory, UMR 1319 Micalis, F-78350 Jouy-en-Josas, France.
authors.forename: S
authors.initials: S
authors.lastname: Miquel
authors.forename: R
authors.initials: R
authors.lastname: Martín
authors.forename: O
authors.initials: O
authors.lastname: Rossi
authors.forename: L G
authors.initials: LG
authors.lastname: Bermúdez-Humarán
authors.forename: J M
authors.initials: JM
authors.lastname: Chatel
authors.forename: H
authors.initials: H
authors.lastname: Sokol
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: J M
authors.initials: JM
authors.lastname: Wells
authors.forename: P
authors.initials: P
authors.lastname: Langella
mesh_terms: D000818:Animals; D041981:Gastrointestinal Tract / Q000382:microbiology* / Q000502:physiology*; D006094:Gram-Positive Bacteria / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D051379:Mice; D013559:Symbiosis