title: MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results.
abstract: OBJECTIVE
  The aim was to identify differences in microRNA expression between patients with and without preeclampsia.
  
  
  METHODS
  Microarray-based study was carried out with placental samples.
  
  
  RESULTS
  Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however, were seen in more than one study and the results agreed in the direction of change. Bioinformatic analysis of these 20 microRNAs identified a wide range of biological functions including apoptosis and cell movement for their mRNA targets.
  
  
  CONCLUSIONS
  The associations between miRNA expression and preeclampsia suggest a potential role for microRNAs in preeclampsia pathobiology.
authors.affiliation: Department of Maternal Fetal Medicine, Geisinger Clinic , Danville, PA , USA .
authors.forename: James S
authors.initials: JS
authors.lastname: Betoni
authors.forename: Kimberly
authors.initials: K
authors.lastname: Derr
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Pahl
authors.forename: Laura
authors.initials: L
authors.lastname: Rogers
authors.forename: Corinna L
authors.initials: CL
authors.lastname: Muller
authors.forename: Roger E
authors.initials: RE
authors.lastname: Packard
authors.forename: David J
authors.initials: DJ
authors.lastname: Carey
authors.forename: Helena
authors.initials: H
authors.lastname: Kuivaniemi
authors.forename: Gerard
authors.initials: G
authors.lastname: Tromp
mesh_terms: D000328:Adult; D017209:Apoptosis; D016022:Case-Control Studies; D002465:Cell Movement; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D035683:MicroRNAs