title: Therapeutic strategies to prevent Alzheimer's disease pathogenesis using a fluorescent conjugated polyelectrolyte.
abstract: Toxic metals accumulation in brain has a significant role in the pathogenesis of Alzheimer's disease (AD) by accelerating amyloid β (Aβ) peptide aggregation. Aβ has high affinity for iron and copper resulting in the generation of neurotoxic hydrogen peroxide, oxidative stress and free radical formation. Water-soluble conjugated polyfluorene derivative poly(9,9-bis(6-sulphate hexyl) fluorene-alt-1,4-phenylene) sodium salt (P1) binds Fe(3+) heme proteins selectively in cerebrospinal fluid (CSF), including ferritin in the Aβ fibrils and diminishes their accumulation. Hence, therapeutic strategies involving clearance of Aβ from brain plaques, metal removal, structurally modifying the aggregates, and preventing them from aggregating again into toxic polypeptides are vital strategies to control AD pathogenesis.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781 039, Assam, India.
authors.forename: Atul K
authors.initials: AK
authors.lastname: Dwivedi
authors.forename: Parameswar K
authors.initials: PK
authors.lastname: Iyer
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000378:metabolism / Q000503:physiopathology; D000682:Amyloid / Q000134:cerebrospinal fluid / Q000187:drug effects / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid* / Q000737:chemistry; D004573:Electrolytes / Q000008:administration & dosage / Q000737:chemistry; D005293:Ferritins / Q000134:cerebrospinal fluid / Q000737:chemistry / Q000378:metabolism; D006418:Heme / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008670:Metals / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry; D066263:Protein Aggregation, Pathological / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D004573:Electrolytes; D008670:Metals; D011108:Polymers; D006418:Heme; D005293:Ferritins
keywords: Alzheimer's disease; amyloid β; anionic polyfluorene; cerebrospinal fluid; neurodegenerative diseases