title: Effect of myopia and age on optic disc margin anatomy within the parapapillary atrophy area.
abstract: OBJECTIVE
  To evaluate the effect of myopia and age on temporal optic disc margin anatomy within the parapapillary atrophy (PPA) area by use of spectral-domain optical coherence tomography (OCT).
  
  
  METHODS
  Fifty young myopic eyes with PPA (myopic PPA group), 50 aged non-myopic eyes with PPA (aged PPA group), and 50 young non-myopic eyes without PPA (control group) were enrolled. High-definition OCT scanning was used to obtain horizontal cross-sectional optic nerve head (ONH) images. By use of these OCT scans we investigated three temporal optic disc margin structures: the configuration of the border tissue of Elschnig; the cross-sectional ONH structure coinciding with the clinically detected optic disc margin; and the integrity of the retinal layers within the PPA area.
  
  
  RESULTS
  The distribution of the configuration of the border tissue of Elschnig and the cross-sectional ONH structure coinciding with the clinically detected optic disc margin of the myopic PPA group differed significantly from those of the control group (P < 0.01) whereas those of the aged PPA group did not (P > 0.05). Other than the photoreceptor layer, the retinal layers within the PPA area were more commonly impaired in the myopic PPA group than in the aged PPA group (P < 0.001).
  
  
  CONCLUSIONS
  Myopia and aging led to different structural changes in temporal optic disc margin anatomy within the PPA area. This finding implies that different mechanisms may underlie myopic and age-related PPA development.
authors.affiliation: Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University, #156 Youngdeungpo-dong 4ga, Youngdeungpo-gu, Seoul, 150-034, Korea, brainh@hanmail.net.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Hwang
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Jung
authors.forename: Young Min
authors.initials: YM
authors.lastname: Park
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Kim
authors.forename: Sungwook
authors.initials: S
authors.lastname: Woo
authors.forename: Joo Hwa
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D006801:Humans; D009216:Myopia / Q000503:physiopathology*; D009896:Optic Atrophy / Q000503:physiopathology*; D009898:Optic Disk / Q000473:pathology*; D041623:Tomography, Optical Coherence; D055815:Young Adult