title: Effect of overnight wear of the Triggerfish(®) sensor on corneal thickness measured by Visante(®) anterior segment optical coherence tomography.
abstract: OBJECTIVE
  To evaluate the effect of overnight wear of the Triggerfish(®) contact lens sensor (CLS) on central corneal thickness (CCT) using the Visante(®) anterior segment optical coherence tomography (AS-OCT).
  
  
  METHODS
  Twelve healthy subjects were studied in a sleep laboratory. An ophthalmic examination including ultrasonic CCT, corneal topography, specular microscopy and AS-OCT CCT was performed. Starting at 7 pm, the Triggerfish(®) CLS was fitted on one randomly selected eye. Similar AS-OCT measurements were taken on both eyes every 2 hr from 8 pm to 8 am. The CLS was removed just after the 8 am measurement session. Measurements were repeated at 9 am.
  
  
  RESULTS
  Twenty-four eyes of 12 subjects were studied (mean age, 22.1 ± 2.4 years; four men/eight women). CCT significantly increased during the night in both CLS and control eyes (p < 0.01). The maximal change was +4.4 ± 1.7% in the CLS eyes and +2.9 ± 1.8% in the control eyes (p < 0.05). Throughout the night, CCT significantly increased more in eyes with CLS than in control eyes (p < 0.05). There were significantly more corneal curvature irregularities after overnight wear of the CLS than in the control eye: +1.63 Dioptre (D) versus -0.02 D in the 3-mm central zone and +3.17 D versus +0.01 D in the 5-mm central zone (p < 0.01).
  
  
  CONCLUSIONS
  CCT and corneal curvature irregularities increased slightly but significantly more in eyes with the Triggerfish(®) CLS than in control eyes during overnight wear. Further studies are required to determine whether the corneal curvature changes modify the signal recorded by the sensor.
authors.affiliation: UJF-Grenoble 1, Grenoble, France; Department of Ophthalmology, CHU Grenoble, Grenoble, France.
authors.forename: Ralitsa
authors.initials: R
authors.lastname: Hubanova
authors.forename: Florent
authors.initials: F
authors.lastname: Aptel
authors.forename: Christophe
authors.initials: C
authors.lastname: Chiquet
authors.forename: Benjamin
authors.initials: B
authors.lastname: Mottet
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Romanet
mesh_terms: D000328:Adult; D019412:Anatomy, Cross-Sectional; D002452:Cell Count; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000033:anatomy & histology*; D019781:Corneal Topography; D004728:Endothelium, Corneal / Q000166:cytology; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013686:Telemetry / Q000295:instrumentation*; D041623:Tomography, Optical Coherence; D055815:Young Adult
keywords: contact lens sensor; corneal thickness; intraocular pressure; optical coherence tomography