title: Guanidine alkaloids from Plumbago zeylanica.
abstract: Eleven new guanidine alkaloids, plumbagines A-G (2-8) and plumbagosides A-D (9-12), as well as two known analogues (1, 13), were isolated from the aerial parts of Plumbago zeylanica. Their structures were elucidated by spectroscopic analyses including 1D and 2D NMR, MS, IR, and CD methods. The absolute configuration of 1 was determined by single-crystal X-ray diffraction of its derivative (1a).
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, People's Republic of China.
authors.forename: Hai-Jian
authors.initials: HJ
authors.lastname: Cong
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Yong
authors.initials: Y
authors.lastname: Zheng
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Huang
authors.forename: Wen-Qiong
authors.initials: WQ
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Leng
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Xuan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005260:Female; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029606:Plumbaginaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D006146:Guanidines