title: In vitro studies investigating the dentin tubule-occlusion properties of an experimental anhydrous stannous fluoride dentifrice.
abstract: OBJECTIVE
  To evaluate in vitro the ability for an experimental anhydrous 0.454% w/w stannous fluoride dentifrice to occlude dentin tubules.
  
  
  METHODS
  Scanning electron microscopy (SEM) was used to assess tubule occlusion and the resistance of the occlusion to dietary acid in a 4-day model, where bovine dentin was treated with product twice daily with acid challenges administered on Days 3 and 4. The reduction in hydraulic conductance of the dentin following treatment was also measured.
  
  
  RESULTS
  The experimental stannous fluoride dentifrice was effective at reducing the hydraulic conductance of dentin by occluding tubules. The occlusion was resistant to challenge with grapefruit juice.
authors.affiliation: GlaxoSmithKline Consumer Healthcare, St Georges Avenue, Weybridge KT13 ODE, United Kingdom. gary.r.burnett@gsk.com
authors.forename: Gary R
authors.initials: GR
authors.lastname: Burnett
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Willson
authors.forename: Robert A
authors.initials: RA
authors.lastname: Lucas
mesh_terms: D019342:Acetic Acid / Q000009:adverse effects; D000818:Animals; D002327:Cariostatic Agents / Q000494:pharmacology; D002417:Cattle; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D003807:Dentin Sensitivity / Q000139:chemically induced / Q000517:prevention & control; D019234:Dentinal Fluid; D004337:Drug Carriers; D005459:Fluorides / Q000494:pharmacology; D005990:Glycerol; D006801:Humans; D057446:Hydrodynamics; D010710:Phosphates / Q000494:pharmacology; D014002:Tin Fluorides / Q000494:pharmacology*
chemical_list: D002327:Cariostatic Agents; C510825:Crest Pro-Health Dentifrice; D004337:Drug Carriers; D010710:Phosphates; D014002:Tin Fluorides; C012980:fluorophosphate; D005990:Glycerol; D019342:Acetic Acid; D005459:Fluorides