title: Small bowel pseudomelanosis associated with oral iron therapy.
abstract: An accumulation of pigment deposits on mucosa, called melanosis or pseudomelanosis, of the small bowel is observed infrequently during endoscopic examination. We describe 6 cases of small bowel pseudomelanosis; the possible etiology of which was chronic iron intake. We observed numerous brown spots in duodenum, jejunum, and terminal ileum during upper and lower endoscopy. Interestingly, all patients have been taking oral iron for several years. Histology showed pigment depositions within macrophages of the lamina propria and a positive Prussian blue stain indicating hemosiderin deposition. Herein, we demonstrate that long term iron therapy may result in pseudomelanosis of small bowel, such as duodenum, jejunum, and ileum.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Seung Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Rok Seon
authors.initials: RS
authors.lastname: Choung
authors.forename: Bo Sung
authors.initials: BS
authors.lastname: Kwon
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Hyun
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Jung
authors.forename: Ja Seol
authors.initials: JS
authors.lastname: Koo
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Yim
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Jai Hyun
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000328:Adult; D000368:Aged; D004386:Duodenum / Q000473:pathology; D004724:Endoscopy; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology*; D007501:Iron / Q000008:administration & dosage / Q000009:adverse effects*; D007583:Jejunum / Q000473:pathology; D008264:Macrophages / Q000166:cytology; D008297:Male; D008548:Melanosis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged
chemical_list: D007501:Iron
keywords: Iron Therapy; Pseudomelanosis; Small Bowel