title: Quality of life in patients with bipolar I disorder: is it related to disorder outcome?
abstract: Bipolar I disorder (BID) and its treatments have shown to be associated with deep impacts on patients' subjective feelings and quality of life (QOL). There are also some comments about impact of these feelings on course and outcome of patients with BID. This study was aimed to evaluate quality of life in patients with BID and to assess its relationship with course of disorder. Fifty patients with BID were recruited based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) from May 2008 and followed for 12 months. Quality of life and mood disorder recurrence were assessed through World Health Organization Quality of Life and SCID-I tools respectively at baseline and after 6 and 12 months. Repeated measures analysis and logistic regression were used to analyze the independent effect of QOL and demographic factors on BID recurrence. Fifty patients (66% male; 48% never married; 48% in primary school level) with mean ± SE age and age of BID onset 33.8±1.5 and 26.6±1.1 years were studied. They had 3.4±0.6 episodes already. Twenty eight percent suffered from recurrences during the follow-up. The QOL scores at baseline, after 6 and 12 months were 70±1.8, 69.6±1.1 and 73±1.3 respectively. There were no significant change in QOL and its sub-domains during the follow-up (P=0.37). QOL showed no independent relationship with BID recurrences (P>0.1). No change in the QOL during the follow-up could denote lack of effectiveness of routine interventions on this factor. Also, short-term follow-up might be concerned as the possible reason. Of prime importance is to consider quality of life independently in treating patients with bipolar disorder.
authors.affiliation: Department of Psychiatry, Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Shabani
authors.forename: Masoud
authors.initials: M
authors.lastname: Ahmadzad-Asl
authors.forename: Kambiz
authors.initials: K
authors.lastname: Zangeneh
authors.forename: Samaneh
authors.initials: S
authors.lastname: Teimurinejad
authors.forename: Sadaf
authors.initials: S
authors.lastname: Kokar
authors.forename: Mojgan
authors.initials: M
authors.lastname: Taban
authors.forename: Behnam
authors.initials: B
authors.lastname: Shariati
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Mousavi Behbahani
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Ghasemzadeh
authors.forename: Sahar
authors.initials: S
authors.lastname: Hasani
authors.forename: Shabnam
authors.initials: S
authors.lastname: Nohesara
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Tat
authors.forename: Shahabali
authors.initials: S
authors.lastname: Shirkhoda
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ghorbani
authors.forename: Seyed Vahid
authors.initials: SV
authors.lastname: Shariat
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012008:Recurrence; D011795:Surveys and Questionnaires