title: Vitamin K status and cognitive function in healthy older adults.
abstract: Evidence is accumulating that vitamin K could have a role in cognition, especially in aging. Using data from the Québec Longitudinal Study on Nutrition and Successful Aging (NuAge), a cross-sectional analysis was conducted to examine the associations between vitamin K status, measured as serum phylloquinone concentrations, and performance in verbal and non-verbal episodic memory, executive functions, and speed of processing. The sample included 320 men and women aged 70 to 85 years who were free of cognitive impairment. After adjustment for covariates, higher serum phylloquinone concentration (log-transformed) was associated with better verbal episodic memory performances (F = 2.43, p = 0.048); specifically with the scores (Z-transformed) on the second (β = 0.47; 95% confidence interval [CI] = 0.13-0.82), third (β = 0.41; 95% CI = 0.06-0.75), and 20-minute delayed (β = 0.47; 95% CI = 0.12-0.82) free recall trials of the RL/RI-16 Free and Cued Recall Task. No associations were found with non-verbal episodic memory, executive functions, and speed of processing. Our study adds evidence to the possible role of vitamin K in cognition during aging, specifically in the consolidation of the memory trace.
authors.affiliation: Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada; Département de Nutrition, Université de Montréal, Montréal, Quebec, Canada.
authors.forename: Nancy
authors.initials: N
authors.lastname: Presse
authors.forename: Sylvie
authors.initials: S
authors.lastname: Belleville
authors.forename: Pierrette
authors.initials: P
authors.lastname: Gaudreau
authors.forename: Carol E
authors.initials: CE
authors.lastname: Greenwood
authors.forename: Marie-Jeanne
authors.initials: MJ
authors.lastname: Kergoat
authors.forename: Jose A
authors.initials: JA
authors.lastname: Morais
authors.forename: Hélène
authors.initials: H
authors.lastname: Payette
authors.forename: Bryna
authors.initials: B
authors.lastname: Shatenstein
authors.forename: Guylaine
authors.initials: G
authors.lastname: Ferland
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D003071:Cognition / Q000502:physiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood; D014705:Verbal Behavior / Q000502:physiology; D014812:Vitamin K / Q000502:physiology*; D010837:Vitamin K 1 / Q000097:blood*
chemical_list: D014280:Triglycerides; D014812:Vitamin K; D010837:Vitamin K 1; D002784:Cholesterol
keywords: Aging; Cognition; Phylloquinone; Vitamin K