title: Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection.
abstract: Neopterin is closely associated with activation of the cellular immune system. Neopterin levels differed between controls and patients with Buruli ulcer disease. No differences between patients with or without paradoxical responses were observed. Therefore, neopterin has no value in detecting paradoxical responses among patients with limited Buruli ulcer disease. Neopterin levels were lower in patients receiving clarithromycin. This finding might indicate a slower cellular immune recovery, with possible consequences in future therapy with clarithromycin.
authors.affiliation: Department of Internal Medicine/Infectious Diseases, University Medical Center Groningen, University of Groningen, The Netherlands. j.de.zeeuw@umcg.nl
authors.forename: Janine
authors.initials: J
authors.lastname: de Zeeuw
authors.forename: Sridevi
authors.initials: S
authors.lastname: Duggirala
authors.forename: Willemien A
authors.initials: WA
authors.lastname: Nienhuis
authors.forename: K Mohammed
authors.initials: KM
authors.lastname: Abass
authors.forename: Wilson
authors.initials: W
authors.lastname: Tuah
authors.forename: Till F
authors.initials: TF
authors.lastname: Omansen
authors.forename: Tjip S
authors.initials: TS
authors.lastname: van der Werf
authors.forename: Ymkje
authors.initials: Y
authors.lastname: Stienstra
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D054312:Buruli Ulcer / Q000188:drug therapy*; D016022:Case-Control Studies; D017291:Clarithromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D019911:Mycobacterium ulcerans / Q000187:drug effects; D019798:Neopterin / Q000097:blood*; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D019798:Neopterin; D017291:Clarithromycin