title: Eukaryotic translation initiation factors in cancer development and progression.
abstract: Eukaryotic gene expression is a complicated process primarily regulated at the levels of gene transcription and mRNA translation. The latter involves four main steps: initiation, elongation, termination and recycling. Translation regulation is primarily achieved during initiation which is orchestrated by 12 currently known eukaryotic initiation factors (eIFs). Here, we review the current state of eIF research and present a concise summary of the various eIF subunits. As eIFs turned out to be critically implicated in different oncogenic processes the various eIF members and their contribution to onset and progression of cancer are featured.
authors.affiliation: Institute of Pathology, Medical University of Graz, 8036 Graz, Austria; Laboratory of Pathology, Hospital Zams, 6511 Zams, Austria.
authors.forename: Rita
authors.initials: R
authors.lastname: Spilka
authors.forename: Christina
authors.initials: C
authors.lastname: Ernst
authors.forename: Anita Kuldeep
authors.initials: AK
authors.lastname: Mehta
authors.forename: Johannes
authors.initials: J
authors.lastname: Haybaeck
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism*; D018450:Disease Progression; D039642:Eukaryotic Initiation Factors / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational
chemical_list: D039642:Eukaryotic Initiation Factors
keywords: Cancer; Eukaryotic initiation factors; Translation initiation