title: Boron tracedrug design for neutron dynamic therapeutics for LDL.
abstract: We describe our solution for removal of the low-density lipoprotein (LDL) depot contained in proteins and lipids as a 'druggable' target for atherosclerotic cardiovascular diseases by neutron dynamic therapy (NDT), which we developed using boron tracedrugs for NDT against bovine serum albumin as a model protein. Thus, we examined, among our developed boron tracedrugs, a boron-containing curcuminoid derivative UTX-51, to destroy freshly isolated human LDL dynamically under irradiated thermal neutron to obtain a decreased intensity of band of LDL treated with UTX-51 and thermal neutron irradiation in their SDS-PAGE and electrophoresis analysis. These results suggest that UTX-51 might be a novel candidate of 'beyond chemical' therapeutic agents for atherosclerotic cardiovascular disease.
authors.affiliation: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Minamijosanjimacho-2, Tokushima, 770-8506, Japan. Hori@bio.tokushima-u.ac.jp.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hori
authors.affiliation: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Minamijosanjimacho-2, Tokushima, 770-8506, Japan.
authors.forename: Yoshijiro
authors.initials: Y
authors.lastname: Nazumi
authors.affiliation: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Minamijosanjimacho-2, Tokushima, 770-8506, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Uto
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy; D001895:Boron / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy; D002417:Cattle; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D009502:Neutrons / Q000627:therapeutic use*; D012710:Serum Albumin, Bovine / Q000378:metabolism
chemical_list: D008077:Lipoproteins, LDL; D012710:Serum Albumin, Bovine; D001895:Boron