title: Enantioselective construction of dihydropyran-fused indoles through chiral calcium phosphate catalyzed oxo-hetero-Diels-Alder reactions by using 2-oxoindolin-3-ylidenes as heterodienes.
abstract: Carbon-carbon bond formation: A highly efficient method for the oxo-hetero-Diels-Alder reaction of 2-oxoindolin-3-ylidenes based on chiral calcium phosphate is described. In general, adducts were obtained with high yields and excellent diastereo- and enantioselectivities (up to 96 % yield, >99:1 endo/exo, >99 % ee; see scheme, Boc = tert-butoxycarbonyl).
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Mao
authors.forename: Weipeng
authors.initials: W
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Haibin
authors.initials: H
authors.lastname: Mao
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
keywords: Diels-Alder reactions; asymmetric catalysis; calcium phosphate; chirality; fused indoles