title: Effect of short-term pair housing of juvenile rhesus macaques (Macaca mulatta) on immunologic parameters.
abstract: Social housing of nonhuman primates (NHP) in an infectious disease setting presents unique challenges, and individual housing is often scientifically justified. At our institute, we recognized an opportunity to limit individual housing to the minimal period necessary by pair-housing NHP after quarantine and separating them just before they are moved into holding rooms for infectious disease studies. To alleviate concerns that pair-housing followed by separation affects the immune system of NHP and makes them unfit as research candidates, we designed a short-term pair-housing study. After a 3-wk baseline period, juvenile rhesus macaques (age, 3 to 4 y) were paired for 7 wk and then separated for 7 wk. During the study, serum cortisol, lymphocyte subsets, and proinflammatory cytokines were measured. The average values for all parameters were significantly lower after separation than during the baseline period. We conclude that short-term pair housing is a viable option at our institute for social housing of NHP.
authors.affiliation: Veterinary Medicine Division (VMD), United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. carrie.benton@amedd.army.mil
authors.forename: Carrie G
authors.initials: CG
authors.lastname: Benton
authors.forename: Michael W
authors.initials: MW
authors.lastname: West
authors.forename: Shane M
authors.initials: SM
authors.lastname: Hall
authors.forename: Shannon T
authors.initials: ST
authors.lastname: Marko
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Johnson
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D016207:Cytokines / Q000276:immunology; D005260:Female; D006799:Housing, Animal / Q000592:standards*; D006854:Hydrocortisone / Q000097:blood; D007249:Inflammation / Q000276:immunology; D008253:Macaca mulatta / Q000276:immunology* / Q000502:physiology; D008297:Male
chemical_list: D016207:Cytokines; D006854:Hydrocortisone