title: Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis.
abstract: BACKGROUND
  To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.
  
  
  METHODS
  Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses.
  
  
  RESULTS
  Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05).
  
  
  CONCLUSIONS
  Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis.
authors.affiliation: Minimally Invasive Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. dralmassi@yahoo.com
authors.forename: Fariba
authors.initials: F
authors.lastname: Almassinokiani
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Mehdizadeh
authors.forename: Elahe
authors.initials: E
authors.lastname: Sariri
authors.forename: Mansour
authors.initials: M
authors.lastname: Rezaei
authors.forename: Alireza
authors.initials: A
authors.lastname: Almasi
authors.forename: Hossein
authors.initials: H
authors.lastname: Akbari
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Pazooki
authors.forename: Masoud
authors.initials: M
authors.lastname: Solaymani-Dodaran
authors.forename: Sara
authors.initials: S
authors.lastname: Asadollah
authors.forename: Jila
authors.initials: J
authors.lastname: Amirkhani
authors.forename: Shahla
authors.initials: S
authors.lastname: Chaichian
authors.forename: Mansoureh
authors.initials: M
authors.lastname: Vahdat
authors.forename: Ashrafsadat
authors.initials: A
authors.lastname: Moosavi
authors.forename: Monir
authors.initials: M
authors.lastname: Ashouri
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Tamannaei
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D010535:Laparoscopy / Q000009:adverse effects*; D017533:Marital Status; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D012008:Recurrence; D019821:Simvastatin / Q000627:therapeutic use*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin