title: The identification of nitric oxide as endothelium-derived relaxing factor.
abstract: The identification of endothelium-derived relaxing factor as nitric oxide (NO) dramatically altered the course of vascular biology, as well as other biomedical disciplines. The ubiquity of this natural product of cell metabolism and the complexity of its biochemistry provide a rich source of molecular mediators of phenotype in health and disease.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jloscalzo@partners.org
authors.forename: Joseph
authors.initials: J
authors.lastname: Loscalzo
mesh_terms: D000818:Animals; D045462:Endothelium-Dependent Relaxing Factors / Q000378:metabolism*; D006801:Humans; D009569:Nitric Oxide / Q000737:chemistry* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology*
chemical_list: D045462:Endothelium-Dependent Relaxing Factors; D009569:Nitric Oxide