title: The Role of PTEN in β-Cell Growth.
abstract: This paper describes the biological functions of PTEN and the PTEN regulated signaling pathway in pancreatic β-cells. PTEN has been shown to regulate the regeneration of β-cells. We review the pathways that are controlled by PTEN signaling and their functions in β-cell regeneration. In particular, we describe the unique effect ofPtendeletion in β-cells. Unlike its effect in other tissues,Ptendeletion does not lead to tumor formation but does enhance β-cell proliferation and function. In addition to the literature review, we also report new results exploring PTEN loss in adult β-cells. We demonstrate that inducing PTEN loss in adult cells has the same regenerative effects previously found for prenatal deletion.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Ni
authors.initials: N
authors.lastname: Zeng
authors.forename: Jennifer-Ann
authors.initials: JA
authors.lastname: Bayan
authors.forename: Lina
authors.initials: L
authors.lastname: He
authors.forename: Bangyan
authors.initials: B
authors.lastname: Stiles
keywords: AKT; PTEN; pancreatic β-cells