title: Quinolines derivatives as novel sunscreening agents.
abstract: Currently, the research and development of sunscreens play an important role on the synthesis of actives that are stable in various kinds of formulations-in addition to their efficiency and broad spectrum of protection against ultraviolet radiation. Our objective here was to synthesize new sunscreening chemical agents using quinoline as a base molecule. Twelve quinoline derivatives were synthesized, four of them novel molecules, and their photoprotective activity was determined in vitro using diffuse transmittance spectrophotometry. We determined their SPF, UVAPF, UVA/UVB ratio, critical wavelength and Boots Star Rating. The quinolines derivatives presented a varied profile of photoprotection, their SPF ranging from 2 to 11 and their UVAPF from 2 to 7. In terms of the critical wavelength, all molecules were considered of broad-spectrum by different classifications. Regarding the Boots Star Rating, one compound received no rating, seven of them received a three stars rating, three received a four stars rating and three were given a five stars rating. The molecules showed in the present work have a wide range of possibilities for creating new sunscreen products, once they have good SPF or UVAPF for single molecules, and they also possess other different qualities that can act synergistically.
authors.affiliation: Núcleo de Pesquisa e Inovação em Ciências da saúde (NUPICS), Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora 36036-900, Brazil.
authors.forename: Hudson C
authors.initials: HC
authors.lastname: Polonini
authors.forename: Rafael M P
authors.initials: RM
authors.lastname: Dias
authors.forename: Isabela O
authors.initials: IO
authors.lastname: Souza
authors.forename: Karla Mara
authors.initials: KM
authors.lastname: Gonçalves
authors.forename: Tiago B B
authors.initials: TB
authors.lastname: Gomes
authors.forename: Nádia R B
authors.initials: NR
authors.lastname: Raposo
authors.forename: Adilson David
authors.initials: AD
authors.lastname: da Silva
mesh_terms: D002626:Chemistry, Pharmaceutical; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013053:Spectrophotometry; D013473:Sunscreening Agents / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011804:Quinolines; D013473:Sunscreening Agents
keywords: Chemical synthesis; Photoprotective activity; Quinolines; Structure–activity relationship; Sunscreening agents/UV filters; Ultraviolet radiation