title: Association between severe obstructive sleep apnea and incident arterial hypertension in the older people population.
abstract: OBJECTIVE
  The impact of sleep-related breathing disorders on the incidence of arterial hypertension (AHT) in the older adults is not well-established. The aim of our study was to test the link between severe obstructive sleep apnea (OSA) and the occurrence of hypertension in older subjects after 3 years.
  
  
  METHODS
  372 normotensive subjects with a mean age of 68.2 years were included in our longitudinal study. All participants had a ventilatory polygraphic recording and an ambulatory blood pressure (BP) monitoring at baseline and after 3 years. Severe OSA was defined by an apnea-hypopnea index (AHI) of ≥ P30 per hour. A new onset of hypertension was defined according to a mean 24-hour value >140mmHg for systolic BP and >85mmHg for diastolic BP or the use of antihypertensive medication.
  
  
  RESULTS
  The baseline factors significantly associated with an increased risk for new-onset hypertension were male gender, obesity, diabetes mellitus (DM), dyslipidemia, and OSA. Multiple logistic regression analyses showed that an AHI ≥30 per hour was independently associated with incident hypertension after 3 years (P=.02; odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1-2.8).
  
  
  CONCLUSIONS
  The presence of severe OSA is associated with new-onset AHT in normotensive elderly (mean age, 68.2 y) subjects.
authors.affiliation: Jean Monnet University, Saint-Etienne, France.
authors.forename: Mailys
authors.initials: M
authors.lastname: Guillot
authors.forename: Emilia
authors.initials: E
authors.lastname: Sforza
authors.forename: Emilie
authors.initials: E
authors.lastname: Achour-Crawford
authors.forename: Delphine
authors.initials: D
authors.lastname: Maudoux
authors.forename: Magali
authors.initials: M
authors.lastname: Saint-Martin
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Barthélémy
authors.forename: Frédéric
authors.initials: F
authors.lastname: Roche
mesh_terms: D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018660:Blood Pressure Monitoring, Ambulatory; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D015994:Incidence; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology*
chemical_list: D000959:Antihypertensive Agents
keywords: Ambulatory blood pressure monitoring; Elderly; Epidemiology; Hypertension; Obstructive sleep apnea; Sleep related breathing disorders