title: Short communication: Analysis of association between the prion protein (PRNP) locus and milk traits in Latxa dairy sheep.
abstract: The purpose of this study was to analyze associations between polymorphisms in the PRNP gene and ewe milk traits. A total of 242,565 lactations of the Latxa breed were used. Milk, fat and protein yields, and fat and protein content from black-faced Latxa from Spanish Basque Country, black-faced Latxa from Navarra, and blond-faced Latxa were collected. To evaluate evidence of association, the different traits were analyzed using an animal model, where the PRNP genotype effect was included or not as a random effect. Adding the PRNP effect to the model improved the fitting for milk yield in black-faced Latxa from Spanish Basque Country and in blond-faced Latxa, for fat yield in black-faced Latxa from Navarra, and for protein yield in blond-faced Latxa. However, the proportion of the phenotypic variance explained by the PRNP effect for milk yield (1.0×10(-3)), fat yield (3.6×10(-3)) and protein yield (9.4×10(-4)) were near zero. The PRNP locus accounts for about 0.5, 1.5, and 0.4% of total genetic (PRNP and polygenic) variance in milk, fat, and protein yield. These values indicated that the PRNP effect is not relevant regarding genetic additive contribution. For breeding purposes, it is unlikely that selection for scrapie resistance will have an effect on the milk traits studied in the Latxa breed.
authors.affiliation: INRA, UMR 1289, Tissus Animaux Nutrition Digestion Ecosystème et Métabolisme, F-31326 Castanet-Tolosan, France. zulma.vitezica@ensat.fr
authors.forename: Z G
authors.initials: ZG
authors.lastname: Vitezica
authors.forename: I
authors.initials: I
authors.lastname: Beltran de Heredia
authors.forename: E
authors.initials: E
authors.lastname: Ugarte
mesh_terms: D000818:Animals; D005223:Fats / Q000032:analysis; D005260:Female; D056726:Genetic Association Studies / Q000662:veterinary; D056426:Genetic Loci / Q000235:genetics*; D005838:Genotype; D007774:Lactation / Q000235:genetics*; D008892:Milk / Q000737:chemistry; D008894:Milk Proteins / Q000032:analysis; D008957:Models, Genetic; D011328:Prions / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D012608:Scrapie / Q000235:genetics; D012756:Sheep / Q000235:genetics*
chemical_list: D005223:Fats; D008894:Milk Proteins; D011328:Prions
keywords: PRNP gene; association analysis; milk trait; sheep