title: A new electroencephalogram classification with reduced recording time in asphyxiated term infants.
abstract: OBJECTIVE
  Conventional electroencephalogram (cEEG) is a reliable predictor of outcome in term infants with hypoxic ischemic encephalopathy (HIE). Early therapeutic hypothermia initiated within 6h after birth is a beneficial treatment in these infants. However, a classification system with reduced cEEG recording time to determine early intervention has not been reported. The aim of this study is to propose a new classification of depression on cEEG with reduced recording time in infants with HIE and to examine the correlation between the classification and short-term outcome.
  
  
  METHODS
  We retrospectively investigated 20 term infants with HIE in whom cEEG was performed within 12h after birth, and deaths or outcomes at 18months of age were assessed. We determined grades 0-3 EEG depression in each 10-min epoch based on the most common EEG patterns of each 20s epoch defined by our criteria.
  
  
  RESULTS
  Eighteen infants could be assessed by depression grade. The Spearman's rank correlation coefficient Rs between the maximum depression grade in 10-min epochs and three-grade outcomes was 0.68 (P=0.002), and that between the minimum one and outcomes was 0.66 (P=0.003). The area under the receiver operating characteristic curve of the maximum and minimum depression grades for predicting abnormal outcome were 0.885 and 0.869, respectively.
  
  
  CONCLUSIONS
  We demonstrated a new cEEG depression classification with a recording time of at least 10min in term infants with HIE and a good correlation with short-term outcome.
authors.affiliation: Department of Pediatrics, Okazaki City Hospital, Okazaki, Japan. Electronic address: kato-jes@umin.ac.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Pediatrics, Okazaki City Hospital, Okazaki, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuji
authors.affiliation: Department of Pediatrics, Okazaki City Hospital, Okazaki, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Hayakawa
authors.affiliation: Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kubota
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kidokoro
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Natsume
authors.affiliation: Faculty of Health and Medical Science, Aichi Shukutoku University, Nagoya, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Okumura
mesh_terms: D001238:Asphyxia Neonatorum / Q000145:classification* / Q000503:physiopathology* / Q000628:therapy; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000145:classification* / Q000503:physiopathology* / Q000628:therapy; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors; D016896:Treatment Outcome
keywords: Classification; Electroencephalogram; Hypoxic ischemic encephalopathy; Prediction; Term infant