title: [Plasmapheresis before thyroidectomy in a patient with thyrotoxicosis and hepatotoxicity by propylthiouracil: case report].
abstract: Thyrotoxicosis is a rare clinical syndrome resulting from an exacerbation of hyperthyroidism, with various etiology and triggering factors. Its approach may be accomplished by blocking the synthesis of hormones, their secretion and/or inhibition of their peripheral action, besides treating the triggering factors. However, in refractory cases, plasmapheresis appears as an important option for treatment. We report a patient with Graves' disease who was admitted with thyrotoxicosis and signs of severe hepatotoxicity induced by propylthiouracil. Plasmapheresis was indicated, with the aim of rapidly reducing thyroid hormones in the preparation for total thyroidectomy.
authors.affiliation: Serviço de Radiologia e Endocrinologia, Hospital Universitário Cassiano Antônio de Moraes, Universidade Federal do Espírito Santo (HUCAMUFES), Vitória, ES, Brasil.
authors.forename: Ronald Freire de
authors.initials: RF
authors.lastname: Almeida
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Comarella
authors.forename: Márcio Barcelos
authors.initials: MB
authors.lastname: Silveira
authors.forename: Alex Rocha Bernardes da
authors.initials: AR
authors.lastname: Silva
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ferri Casini
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects*; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D011300:Preoperative Care / Q000379:methods; D011441:Propylthiouracil / Q000009:adverse effects*; D013965:Thyroidectomy; D013971:Thyrotoxicosis / Q000139:chemically induced*; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil; D013974:Thyroxine