title: Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis.
abstract: The complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Beijing 100190, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Qun
authors.initials: Q
authors.lastname: Luo
authors.forename: Yu
authors.initials: Y
authors.lastname: Lin
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiuli
authors.initials: X
authors.lastname: Wang
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Du
authors.forename: Xiang
authors.initials: X
authors.lastname: Hao
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Shuang
authors.initials: S
authors.lastname: Lü
authors.forename: Liyun
authors.initials: L
authors.lastname: Ji
authors.forename: Xianchan
authors.initials: X
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Fuyi
authors.initials: F
authors.lastname: Wang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006801:Humans; D006868:Hydrolysis; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011799:Quinazolines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000814:Aniline Compounds; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D011799:Quinazolines; D012428:Ruthenium; D066246:ErbB Receptors