title: Headache as a presenting feature in patients with serotonin syndrome: a case series.
abstract: BACKGROUND
  Serotonin syndrome (SS) is a drug-induced constellation of various clinical features that result from excess central serotonergic tone. The clinical features range from barely perceptible to life-threatening conditions.
  
  
  METHODS
  We describe four patients with acute headache (four days to three weeks) who were receiving serotonergic drugs for other indications. There was a temporal relation between the administration of the serotonergic drugs and the development of the headaches. All four patients fulfilled the Hunter Serotonin Toxicity Criteria for SS. In parallel, two patients fulfilled the Sternbach's criteria for SS. Discontinuation of the serotonergic drugs and the administration of cyprohepatadine led to complete improvement in three to seven days in all four patients.
  
  
  CONCLUSIONS
  A review of the literature suggests that some overlaps exist in the pathophysiology between SS and headache disorders, including medication-overuse headache. The overlap is also in the management. The drugs found to be effective in SS (cyproheptadine, chlorpromazine, olanzapine, etc.) are also known to have positive effects on some headache disorders.
  
  
  CONCLUSIONS
  Physicians should consider the diagnosis of SS in patients with new onset or worsening headache after the addition of serotonergic drugs, especially in the presence of objective signs on examination suggestive of the disorder such as tremor, fever, hyperreflexia, diaphoresis or tachycardia.
authors.affiliation: Department of Neurology, Medical College, SSG Hospital, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Prakash
authors.forename: Pooja
authors.initials: P
authors.lastname: Belani
authors.forename: Aditi
authors.initials: A
authors.lastname: Trivedi
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects; D000928:Antidepressive Agents / Q000009:adverse effects*; D005260:Female; D006261:Headache / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000378:metabolism; D018490:Serotonin Agents / Q000009:adverse effects*; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000378:metabolism; D014147:Tramadol / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D000928:Antidepressive Agents; D018490:Serotonin Agents; D012701:Serotonin; D014147:Tramadol
keywords: Headache; antidepressant; drug-induced headache; serotonin; serotonin syndrome