title: Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment.
abstract: OBJECTIVE
  In the present study, the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated.
  
  
  METHODS
  Among 104 cervical cancer patients selected for the present study, 54 and 50 patients were treated with chemo- and radiotherapy respectively. Plasma Se, Zn, Cu and some enzymatic antioxidants activities were estimated in serum before and after the treatment.
  
  
  RESULTS
  The decreased levels of serum trace elements, glutathione peroxidase activity and total antioxidant capacity, and increased malondialdehyde, glutathion reductase was observed in cervical cancer patients when compared to healthy controls. The increased concentration of serum Se, Zn was observed in patients treated with chemotherapy. Simultaneously there was a significant (P < 0.001) increase in glutathione peroxidase and total antioxidant capacity, and significant decrease (P < 0.05) in malondialdehyde and glutathion reductase levels in the serum of patients treated with chemotherapy compared to the patients treated with radiotherapy.
  
  
  CONCLUSIONS
  The results demonstrated that chemotherapy but not radiotherapy results in significant increase in the trace elements levels and antioxidant activities in blood serum of cervical cancer patients.
authors.affiliation: Department of Biotechnology, Dravidian University, Kuppam 517426, AP, India.
authors.forename: D
authors.initials: D
authors.lastname: Subramanyam
authors.forename: K V
authors.initials: KV
authors.lastname: Subbaiah
authors.forename: W
authors.initials: W
authors.lastname: Rajendra
authors.forename: V
authors.initials: V
authors.lastname: Lokanatha
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D000975:Antioxidants / Q000378:metabolism; D003300:Copper / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008315:Malondialdehyde / Q000097:blood; D012643:Selenium / Q000097:blood; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy; D015032:Zinc / Q000097:blood
chemical_list: D000975:Antioxidants; D003300:Copper; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D008315:Malondialdehyde; D012643:Selenium; D015032:Zinc