title: Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case.
abstract: We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature.
authors.affiliation: First Department of Surgery, Yamanashi University School of Medicine, 1110 Shimokato, Chuo-city, Yamanashi, 409-3898, Japan, masam@yamanashi.ac.jp.
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsuda
authors.forename: Hidetake
authors.initials: H
authors.lastname: Amemiya
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Kawaida
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Okamoto
authors.forename: Naohiro
authors.initials: N
authors.lastname: Hosomura
authors.forename: Masami
authors.initials: M
authors.lastname: Asakawa
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Sano
authors.forename: Utaroh
authors.initials: U
authors.lastname: Motosugi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Tadao
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujii
mesh_terms: D000293:Adolescent; D044466:Asian People; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000601:surgery* / Q000648:ultrastructure; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7 / Q000032:analysis; D008113:Liver Neoplasms / Q000175:diagnosis / Q000601:surgery* / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008297:Male; D064347:Microscopy, Electrochemical, Scanning; D011516:Prothrombin / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D053552:Keratin-7; D011516:Prothrombin