title: Long-term result of a biodegradable osteo-inductive copolymer for the treatment of orbital blowout fracture.
abstract: OBJECTIVE
  We have recently reconstructed the orbital wall using a bioabsorbable osteo-inductive copolymer as a support material for the bone defects in patients with orbital blowout fracture. The purpose of this study was to investigate a 2-year follow-up after implantation.
  
  
  METHODS
  In order to investigate the efficacy and safety of the bioabsorbable osteo-inductive copolymer HA-P(LA/CL), hydroxyapatite-poly(l-lactide-ε-caprolactone), we measured CT density of the implanted copolymers in 7 patients at such time points as 1 week, 6 months and 2 years after surgery along with the long-term outcomes with regard to postoperative complications.
  
  
  RESULTS
  Five patients in whom the intraoperative maximum width of the bone defect was less than 15 mm demonstrated the fracture types of either linear or trap-door. All patients treated with HA-P(LA/CL) copolymer indicated good bone formation with high CT density (>500) at 2 years postoperatively. In contrast, 2 patients in whom the intraoperative maximum width of the bone defect was more than 16 mm demonstrated a punched-out type fracture. Postoperative CT of the HA-P(LA/CL) copolymer showed low density (28.0 and 173.4) at 2 years postoperatively, indicative of limited bone formation. None of the cases demonstrated significant postoperative complications such as diplopia, enophthalmos, infection and extrusion of the implant material.
  
  
  CONCLUSIONS
  The results of this study demonstrate that surgical treatment of orbital blowout fractures using bioabsorbable osteo-inductive copolymer was useful in linear and trap-door fractures.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Kinki University Faculty of Medicine, 377-2, Ohno-higashi, Osaka-sayama, Osaka 5898511, Japan. Electronic address: morotomi@med.kindai.ac.jp.
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Morotomi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Field of Maxillofacial Rehabilitation Advanced Therapeutic Course, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima 8908544, Japan.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Matsunaga
authors.affiliation: Department of Plastic and Reconstructive Surgery, Kinki University Faculty of Medicine, 377-2, Ohno-higashi, Osaka-sayama, Osaka 5898511, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Kusuhara
authors.affiliation: Department of Plastic and Reconstructive Surgery, Kinki University Faculty of Medicine, 377-2, Ohno-higashi, Osaka-sayama, Osaka 5898511, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Itani
authors.affiliation: Department of Plastic and Reconstructive Surgery, Kinki University Faculty of Medicine, 377-2, Ohno-higashi, Osaka-sayama, Osaka 5898511, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Nakao
authors.affiliation: Department of Plastic and Reconstructive Surgery, Kinki University Faculty of Medicine, 377-2, Ohno-higashi, Osaka-sayama, Osaka 5898511, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Asamura
authors.affiliation: Department of Plastic and Reconstructive Surgery, Kinki University Faculty of Medicine, 377-2, Ohno-higashi, Osaka-sayama, Osaka 5898511, Japan.
authors.forename: Noritaka
authors.initials: N
authors.lastname: Isogai
mesh_terms: D020341:Absorbable Implants; D000293:Adolescent; D000328:Adult; D000368:Aged; D015519:Bone Density / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009915:Orbit / Q000000981:diagnostic imaging; D009917:Orbital Fractures / Q000000981:diagnostic imaging / Q000601:surgery*; D010012:Osteogenesis / Q000502:physiology; D011091:Polyesters / Q000737:chemistry*; D011183:Postoperative Complications; D019651:Plastic Surgery Procedures / Q000295:instrumentation / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C499699:hydroxyapatite-polylactide; C062968:lactide-caprolactone copolymer; D017886:Durapatite
keywords: Bioabsorbable copolymer; Long-term results; Orbital blowout fracture