title: Ligand-dependent site-selective Suzuki cross-coupling of 3,5-dichloropyridazines.
abstract: General methods for the highly site-selective Suzuki monocoupling of 3,5-dichloropyridazines have been discovered. By changing the ligand employed, the preferred coupling site can be switched from the 3-position to the 5-position, typically considered the less reactive C-X bond. These conditions are applicable to the coupling of a wide variety of aryl-, heteroaryl-, and vinylboronic acids with high selectivities, thus enabling the rapid construction of diverse arrays of diarylpyradazines in a modular fashion.
authors.affiliation: Department of Discovery Chemistry, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. xing.dai@merck.com
authors.forename: Xing
authors.initials: X
authors.lastname: Dai
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Chen
authors.forename: Stephanie
authors.initials: S
authors.lastname: Garrell
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Li-Kang
authors.initials: LK
authors.lastname: Zhang
authors.forename: Anandan
authors.initials: A
authors.lastname: Palani
authors.forename: Gregory
authors.initials: G
authors.lastname: Hughes
authors.forename: Ravi
authors.initials: R
authors.lastname: Nargund
mesh_terms: D008024:Ligands; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D008024:Ligands; D011725:Pyridines