title: Keep PNUTS in your heart.
abstract: Aging is a major factor in many cardiovascular diseases. The molecular factors that regulate age-related changes in cardiac physiology and contribute to the increased cardiovascular risk in the elderly are not fully understood. A study recently published in Nature suggests a specific role for microRNAs (miRNAs) in regulating cardiac aging and function, challenging the concept that aging is an inevitable process in the heart.
authors.affiliation: Harvard Stem Cell Institute, The Brigham Regenerative Medicine Center, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Francesco S
authors.initials: FS
authors.lastname: Loffredo
authors.forename: James R
authors.initials: JR
authors.lastname: Pancoast
authors.forename: Richard T
authors.initials: RT
authors.lastname: Lee
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology*; D035683:MicroRNAs / Q000235:genetics*; D009206:Myocardium / Q000378:metabolism*
chemical_list: D035683:MicroRNAs