title: Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis.
abstract: BACKGROUND
  The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea.
  
  
  METHODS
  From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis.
  
  
  RESULTS
  Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor (P = .040).
  
  
  CONCLUSIONS
  Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.
authors.affiliation: Department of Surgery, University of Ulsan College of Medicine & Asan Medical Center, Seoul, Korea.
authors.forename: Chang Sik
authors.initials: CS
authors.lastname: Yu
authors.forename: Hae Ran
authors.initials: HR
authors.lastname: Yun
authors.forename: Eung Jin
authors.initials: EJ
authors.lastname: Shin
authors.forename: Kang Yong
authors.initials: KY
authors.lastname: Lee
authors.forename: Nam Kyu
authors.initials: NK
authors.lastname: Kim
authors.forename: Seok-Byung
authors.initials: SB
authors.lastname: Lim
authors.forename: Seong Taek
authors.initials: ST
authors.lastname: Oh
authors.forename: Sung-Bum
authors.initials: SB
authors.lastname: Kang
authors.forename: Won Joon
authors.initials: WJ
authors.lastname: Choi
authors.forename: Woo Yong
authors.initials: WY
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012007:Rectum / Q000601:surgery*; D012189:Retrospective Studies
keywords: Local excision; Neoadjuvant chemoradiation therapy; Rectal cancer