title: Synthesis, Structural Elucidation, and In Vitro Antitumor Activities of Some Pyrazolopyrimidines and Schiff Bases Derived from 5-Amino-3-(arylamino)-1H-pyrazole-4-carboxamides.
abstract: The reaction of 5-amino-3-(arylamino)-1H-pyrazole-4-carboxamides 1a,b with acetylacetone 2 and arylidenemalononitriles 5a-c yielded the pyrazolo[1,5-a]-pyrimidine derivatives 4a,b and 7a-f respectively. On the other hand, Schiff bases 9a,b and 12a-j were obtained upon treatment of carboxamides 1a,b with isatin 8 and some selected aldehydes 11a-e. The newly synthesized compounds were characterized by analytical and spectroscopic data. Representative examples of the synthesized products 4a,b, 7e, 7f, 9b, 12b-f, 12h, and 12j were screened for their in vitro antitumor activities against different human cancer cell lines and the structure-activity relationship (SAR) was discussed.
authors.affiliation: Department of Organometallic and Organometalloid Chemistry, National Research Centre, El-Behoos Street, Dokki, 12622 Cairo, Egypt.
authors.forename: Taghrid S
authors.initials: TS
authors.lastname: Hafez
authors.forename: Souad A
authors.initials: SA
authors.lastname: Osman
authors.forename: Hisham Abdallah A
authors.initials: HA
authors.lastname: Yosef
authors.forename: Amira S Abd
authors.initials: AS
authors.lastname: El-All
authors.forename: Ashraf S
authors.initials: AS
authors.lastname: Hassan
authors.forename: Abdallah A
authors.initials: AA
authors.lastname: El-Sawy
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Abdallah
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Youns
keywords: 5-Aminopyrazole-4-carboxamides; Antitumor agents; Ferrocenecarboxaldehyde; Pyrazolo[1,5-a]pyrimidines; Schiff bases