title: Adiponectin and leptin: new targets in inflammation.
abstract: Inflammation is a complex mechanism of cell/tissue responses to injuries triggered by multiple causes, including trauma, pathogens or autoimmune abnormal responses. In the last years, a novel line of thought is emerging by giving a more holistic vision of chronic arthropathies through a recently identified group of molecules, called adipokines. Actually, most of these recently identified factors, produced prevalently by white adipose tissue but also by cells of the joints (chondrocytes and synovial fibroblasts) and immune cells, play a significant role in chronic inflammation. Adipokines dysregulation has emerged as a common characteristic of chronic inflammation in rheumatic diseases in particular when obesity or, more precisely, adipose tissue dysfunction is associated with common rheumatic diseases, such as osteoarthritis and rheumatoid arthritis. In this MiniReview, we discuss the role of adipokines in osteoarthritis and rheumatoid arthritis providing an updated overview of their pathophysiological role and potential use as therapeutic targets.
authors.affiliation: NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), SERGAS, Santiago University Clinical Hospital, Institute of Medical Research (IDIS), Santiago de Compostela, Spain.
authors.forename: Morena
authors.initials: M
authors.lastname: Scotece
authors.forename: Javier
authors.initials: J
authors.lastname: Conde
authors.forename: Verónica
authors.initials: V
authors.lastname: López
authors.forename: Francisca
authors.initials: F
authors.lastname: Lago
authors.forename: Jesús
authors.initials: J
authors.lastname: Pino
authors.forename: Juan Jesús
authors.initials: JJ
authors.lastname: Gómez-Reino
authors.forename: Oreste
authors.initials: O
authors.lastname: Gualillo
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000503:physiopathology / Q000628:therapy*; D020738:Leptin / Q000378:metabolism*; D010003:Osteoarthritis / Q000503:physiopathology / Q000628:therapy
chemical_list: D052242:Adiponectin; D020738:Leptin