title: Forty-five years of keratoprosthesis study and application at the Filatov Institute: a retrospective analysis of 1 060 cases.
abstract: OBJECTIVE
  To present results of the keratoprosthesis method used at The Filatov Institute of Eye Diseases and Tissue Therapy.
  
  
  METHODS
  A retrospective case series analysis was used to describe the development of new types of keratoprostheses and methods of implantation as well as different ways of leukoma strengthening.
  
  
  RESULTS
  Keratoprosthesis was performed in 1 060 eyes of 1 040 patients with leukomas of different etiology: burns, 725 eyes (68.4%); trauma, 120 eyes (11.3%); keratitis and ocular pemphigoid, 108 eyes (10.2%); and bullous keratopathy, 107 eyes (10.1%). Visual acuity before keratoprosthesis consisted of light perception in 962 eyes (92%), and 98 eyes (8%) had minimal visual acuity (1/200-1/50). Both eyes were blind (visual acuity less than 1/200) in 955 patients (91.8%). The period of blindness varied from 1 to 52 years. As a result of keratoprosthesis, visual acuity of ≥1/200 was restored in 1 023 of 1 060 eyes (96.5%). Visual acuity of 20/200-20/20 was achieved in 716 eyes (67.5%). At the last follow-up visit visual acuity of ≥1/200 was preserved in 806 eyes (76%), visual acuity of 20/200-20/20 was measured in 583 of 1 060 eyes (55%) and good keratoprosthesis fixation in the cornea was achieved in 986 of 1 060 eyes (93%). The minimal follow-up was 12 months (range, 12 months to 37 years, median 5 years).
  
  
  CONCLUSIONS
  Our techniques of keratoprosthesis effectively restore vision in patients with leukomas that cannot be treated by optical corneal grafting.
authors.affiliation: Department of Eye Burns, Ophthalmic Plastic Surgery, Keratoplasty and Keratoprosthesis, the Filatov Institute of Eye Diseases and Tissue Therapy, Odessa, Ukraine.
authors.forename: Stanislav
authors.initials: S
authors.lastname: Iakymenko
keywords: artificial cornea; corneal grafting; keratoprosthesis; leukoma