title: Diffusion-weighted imaging of the breast: comparison of b-values 1000 s/mm² and 1500 s/mm².
abstract: OBJECTIVE
  We compared diffusion-weighted imaging (DWI) of the breast using 2 different b-values to determine the optimal b-value for greatest signal contrast between tumors and normal tissue of the breast.
  
  
  METHODS
  We performed DWI of the breast at b-values of 1000 s/mm(2) and 1500 s/mm(2) in 120 patients (121 lesions, 19 benign, 102 malignant) and visually scored image quality with regard to artifact and visibility of tumors. We quantitatively evaluated the signal-to-noise ratio (SNR) of the tumor and contrast-to-noise ratio (CNR) and contrast ratio (CR) between the tumor and normal breast parenchyma.
  
  
  RESULTS
  The CR of invasive carcinoma (IC), ductal carcinoma in situ (DCIS), and benign tumors significantly improved with b=1500 s/mm(2) compared with b=1000 s/mm(2). The SNR and CNR were significantly lower with b=1500 s/mm(2) than b=1000 s/mm(2) despite the increasing number of excitations at b=1500 s/mm(2). At b=1500 s/mm(2), the difference in SNR, CNR, and CR between IC and DCIS and benign tumors was statistically significant.
  
  
  CONCLUSIONS
  DWI may depict breast tumors more clearly with b=1500 s/mm(2) than b=1000 s/mm(2).
authors.affiliation: Department of Diagnostic Radiology, Kitasato University School of Medicine.
authors.forename: Reiko
authors.initials: R
authors.lastname: Woodhams
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Inoue
authors.forename: Saadallah
authors.initials: S
authors.lastname: Ramadan
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hata
authors.forename: Masanori
authors.initials: M
authors.lastname: Ozaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001943:Breast Neoplasms / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity