title: Mandibular Ewing sarcoma with chromosomal translocation t(21;22)(q22;q12).
abstract: Ewing sarcoma (ES) is a primary bone malignant neoplasm and is the second most common primary malignancy of the bone found in childhood and adolescence after osteosarcoma. ES has an annual frequency in the population younger than 20 years of approximately 2.9 per million. ES occurs most frequently in the long bones of the extremities and pelvis and very rarely in the jaw. Recently, it was revealed that chromosomal translocation t(11;22)(q24;q12), which fuses the EWS gene on chromosome 22 and the FLI-1 gene on chromosome 11, occurs in most cases of ES. We report here a rare case of mandibular ES in a 10-year-old child with chromosomal translocation t(21;22)(q22;q12) in which the EWS gene is fused with the ERG gene on chromosome 21.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Shibasaki
authors.forename: Toshinori
authors.initials: T
authors.lastname: Iwai
authors.forename: Jiro
authors.initials: J
authors.lastname: Maegawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Inayama
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yokosuka
authors.forename: Shumpei
authors.initials: S
authors.lastname: Yokota
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ohta
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Matsui
authors.forename: Kenji
authors.initials: K
authors.lastname: Mitsudo
authors.forename: Iwai
authors.initials: I
authors.lastname: Tohnai
mesh_terms: D002648:Child; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D012512:Sarcoma, Ewing / Q000235:genetics* / Q000628:therapy; D014157:Transcription Factors / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: C450460:EWS-ERG fusion protein, human; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors