title: Estimation of perilymph enhancement after intratympanic administration of Gd-DTPA by fast T₁-mapping with a dual flip angle 3D spoiled gradient echo sequence.
abstract: Eleven patients with suspected Ménière's disease received intratympanic (IT) administration of gadolinium (gadopentetate dimeglumine; Gd) prior to acquisition of 3-dimensional (3D) fluid-attenuated inversion recovery (FLAIR), 3D real inversion recovery (IR), and fast T₁ mapping by dual flip angle 3D gradient echo (FT₁-map) imaging sequences to evaluate the degree of perilymph enhancement. Though 3-dimensional FLAIR could detect lower concentrations of gadolinium than 3D real IR, in 2 patients, poor enhancement still prevented visualization of the endolymphatic space using 3D FLAIR. We could predict poor contrast enhancement in these 2 patients using the FT₁-map technique.
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine.
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawai
authors.forename: Kiminori
authors.initials: K
authors.lastname: Bokura
authors.forename: Michihiko
authors.initials: M
authors.lastname: Sone
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008575:Meniere Disease / Q000473:pathology*; D008875:Middle Aged; D010498:Perilymph / Q000166:cytology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014432:Tympanic Membrane / Q000187:drug effects / Q000473:pathology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA