title: Rotavirus specific plasma secretory immunoglobulin in children with acute gastroenteritis and children vaccinated with an attenuated human rotavirus vaccine.
abstract: Rotavirus (RV)-specific secretory immunoglobulin (RV-SIg) has been previously detected in serum of naturally RV infected children and shown to reflect the intestinal Ig immune response. Total plasma SIgA and plasma RV-SIg were evaluated by ELISA in children with gastroenteritis due or not due to RV infection and in 50 children vaccinated with the attenuated RIX4414 human RV vaccine and 62 placebo recipients. RV-SIg was only detected in children with evidence of previous RV infection or with acute RV gastroenteritis. Vaccinees had higher RV-SIg titers than placebo recipients and RV-SIg titers increased after the second vaccine dose. RV-SIg measured after the second dose correlated with protection when vaccinees and placebo recipients were analyzed jointly. RV-SIg may serve as a valuable correlate of protection for RV vaccines.
authors.affiliation: Instituto de Genética Humana; Facultad de Medicina; Pontificia Universidad Javeriana; Bogotá, Colombia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Herrera
authors.forename: Camilo
authors.initials: C
authors.lastname: Vásquez
authors.forename: Blaise
authors.initials: B
authors.lastname: Corthésy
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Franco
authors.forename: Juana
authors.initials: J
authors.lastname: Angel
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005759:Gastroenteritis / Q000276:immunology* / Q000821:virology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000097:blood*; D007223:Infant; D008297:Male; D010919:Placebos / Q000008:administration & dosage; D010949:Plasma / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology* / Q000821:virology; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D007071:Immunoglobulin A, Secretory; D010919:Placebos; D022243:Rotavirus Vaccines
keywords: correlate of protection; rotavirus; secretory immunoglobulin; vaccine