title: Successful management of multidrug-resistant Pseudomonas aeruginosa pneumonia after kidney transplantation in a dog.
abstract: An 8-year-old male mongrel dog that had undergone renal transplantation was presented 25 days later with an acute cough, anorexia and exercise intolerance. During the investigation, neutrophilic leukocytosis was noted, and thoracic radiographs revealed caudal lung lobe infiltration. While being treated with two broad-spectrum antibiotics, clinical signs worsened. Pneumonia due to infection with multidrug-resistant (MDR) Pseudomonas (P.) aeruginosa, sensitive only to imipenem and amikacin, was confirmed by bacteria isolation. After treatment with imipenem-cilastatin without reducing the immunosuppressant dose, clinical signs completely resolved. During the 2-year follow-up period, no recurrence was observed. To the best of authors' knowledge, this is the first report of pneumonia caused by MDR P. aeruginosa in a renal recipient dog and successful management of this disease.
authors.affiliation: Section of Veterinary Surgery, College of Veterinary Medicine, Kangwon National University, Chuncheon 200-701, Republic of Korea.
authors.forename: Kyung-Mee
authors.initials: KM
authors.lastname: Park
authors.forename: Hyun-Suk
authors.initials: HS
authors.lastname: Nam
authors.forename: Heung-Myong
authors.initials: HM
authors.lastname: Woo
mesh_terms: D000818:Animals; D015377:Cilastatin / Q000627:therapeutic use*; D000077728:Cilastatin, Imipenem Drug Combination; D004283:Dog Diseases / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D004285:Dogs; D004338:Drug Combinations; D024901:Drug Resistance, Multiple, Bacterial / Q000276:immunology; D015378:Imipenem / Q000627:therapeutic use*; D016867:Immunocompromised Host / Q000276:immunology*; D016030:Kidney Transplantation / Q000662:veterinary*; D008297:Male; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000276:immunology*
chemical_list: D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination