title: The role of transcription-independent damage signals in the initiation of epithelial wound healing.
abstract: Wound healing is an essential biological process that comprises sequential steps aimed at restoring the architecture and function of damaged cells and tissues. This process begins with conserved damage signals, such as Ca2+, hydrogen peroxide (H2O2) and ATP, that diffuse through epithelial tissues and initiate immediate gene transcription-independent cellular effects, including cell shape changes, the formation of functional actomyosin structures and the recruitment of immune cells. These events integrate the ensuing transcription of specific wound response genes that further advance the wound healing response. The immediate importance of transcription-independent damage signals illustrates that healing a wound begins as soon as damage occurs.
authors.affiliation: Centro de Estudos de Doenças Crónicas (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria, 130, 1169-056 Lisboa, Portugal.
authors.forename: João V
authors.initials: JV
authors.lastname: Cordeiro
authors.forename: António
authors.initials: A
authors.lastname: Jacinto
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D015398:Signal Transduction; D014158:Transcription, Genetic; D014945:Wound Healing
chemical_list: D047908:Intracellular Signaling Peptides and Proteins