title: Polycystic ovary syndrome is associated with P-wave prolongation and increased P-wave dispersion.
abstract: BACKGROUND
  The polycystic ovary syndrome (PCOS) is associated with various cardiac manifestations including cardiac arrhythmias. P-wave dispersion (Pdis) is an appealing marker for predicting the risk of developing atrial arrhythmias. The purpose of this study was to evaluate P-wave durations and Pdis in patients with PCOS.
  
  
  METHODS
  Forty adult patients with PCOS and 46 age- and sex-matched healthy individuals were included in this study. P-wave maximum duration (Pmax) and P-wave minimum duration (Pmin) were calculated on the 12-lead electrocardiogram, and the difference between the Pmax and the Pmin was defined as Pdis. All individuals also underwent transthoracic echocardiographic evaluation.
  
  
  RESULTS
  Pmax and Pdis were significantly higher in patients with PCOS compared with controls (p = 0.007, p < 0.001, respectively). There was no difference in Pmin duration between both the groups (p = 0.2). Waist-to-hip ratio, insulin and homeostasis model assessment of insulin resistance (HOMA-IR) were higher in the PCOS group. Early mitral inflow deceleration time (DT) (p < 0.001) and isovolumetric relaxation time (p = 0.003) were longer in PCOS group. Waist-to-hip ratio, DT, E/A ratio and diastolic blood pressure correlated with Pdis.
  
  
  CONCLUSIONS
  Patients with PCOS have prolonged Pmax and Pdis. The increase in those parameters may be an indicator for identification of patients at increased risk of atrial fibrillation.
authors.affiliation: Bezmialem Vakif University, Faculty of Medicine, Department of Cardiology, 34093 Fatih/Istanbul, Turkey. drercanerdogan@gmail.com
authors.forename: Ercan
authors.initials: E
authors.lastname: Erdogan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akkaya
authors.forename: Murat
authors.initials: M
authors.lastname: Turfan
authors.forename: Gonca
authors.initials: G
authors.lastname: Batmaz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bacaksız
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Tasal
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Ilhan
authors.forename: Seref
authors.initials: S
authors.lastname: Kul
authors.forename: Osman
authors.initials: O
authors.lastname: Sönmez
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Vatankulu
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Tasan
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000453:epidemiology / Q000209:etiology*; D015992:Body Mass Index; D016022:Case-Control Studies; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology*; D012307:Risk Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D055815:Young Adult