title: [Orofacial closure defects: cleft lip and palate. A literature review].
abstract: Orofacial clefts are a common problem that can lead to significant healthcare use and costs, as well as suffering on the part of the affected individuals and families. There are several theories explaining their origin, but some of the findings are inconsistent. The most accepted theories involve a major genetic basis that could be modified by the presence of external agents. Understanding the underlying causes could help to prevent its occurrence, an area in which the family physician can play an important role.
authors.affiliation: Medicina de Familia y Comunitaria, Centro de Salud Cea, Cea, Ourense, España.
authors.forename: G H
authors.initials: GH
authors.lastname: Díaz Casado
authors.forename: G J
authors.initials: GJ
authors.lastname: Díaz Grávalos
mesh_terms: D002971:Cleft Lip / Q000209:etiology*; D002972:Cleft Palate / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D012307:Risk Factors
keywords: Aetiology; Cleft lip; Cleft palate; Environment and public health; Epidemiology; Epidemiología; Etiología; Factores de riesgo; Fisura del paladar; Labio leporino; Medio ambiente y salud pública; Risk factors