title: Acute sleep deprivation is associated with increased arterial stiffness in healthy young adults.
abstract: BACKGROUND
  Arterial stiffness and its hemodynamic consequences are known to be associated with increased cardiovascular morbidity and mortality. Pulse wave velocity (PWV) and augmentation index (AIx) are noninvasive indicators of the arterial stiffness and wave reflection. Sleep deprivation (SD) is known to be associated with increased incidence of adverse cardiovascular events. The aim of this study was to investigate whether there is an association between acute SD and arterial stiffness parameters in healthy adults, which has not been studied previously.
  
  
  METHODS
  The study population consisted of 42 healthy volunteers (18 males, mean age 30.0 ± 4.5 years). Measurements of arterial stiffness were carried out by using a Mobil-O-Graph arteriograph system. Arterial stiffness measurements were obtained both after a night with regular sleep (RS) and after a night with SD.
  
  
  RESULTS
  Mean sleep time was significantly lower after the night of SD when compared after RS (0.73 ± 1.39 versus 7.33 ± 0.52 h, p<0.001). Peripheral systolic blood pressure, peripheral pulse pressure, and cardiac output were significantly higher after SD when compared after RS (p=0.032, 0.007, and 0.003, respectively). PWV was significantly higher (5.33 ± 0.46 versus 5.15 ± 0.26 m/s, p=0.001), and AIx was significantly lower (20.5 ± 11.9 versus 26.0 ± 8.4 %, p=0.008) after the night of SD when compared after the RS. While PWV was significantly higher (p=0.008), and AIx was significantly lower (p=0.039) in male subjects, only PWV was significantly higher (p=0.009) in female subjects. Sleep time correlated with AIx (p=0.034; r=0.233) and inversely correlated with PWV (p=0.044; r=-0.222).
  
  
  CONCLUSIONS
  In the present study, we demonstrated that even one night of SD is associated with increased arterial stiffness in healthy adults. The present findings suggest that adverse effects of SD on cardiovascular system might be at least in part due to increased arterial stiffness which needs to be tested with large-scale studies and in the chronic SD setting.
authors.affiliation: Faculty of Medicine, Department of Cardiology, Marmara University, Fevzi Cakmak Mahallesi, Mimar Sinan Caddesi, No. 41, Pendik, Istanbul, Turkey, drsunbul@yahoo.com.tr.
authors.forename: Murat
authors.initials: M
authors.lastname: Sunbul
authors.forename: Batur Gonenc
authors.initials: BG
authors.lastname: Kanar
authors.forename: Erdal
authors.initials: E
authors.lastname: Durmus
authors.forename: Tarik
authors.initials: T
authors.lastname: Kivrak
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sari
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D063177:Pulse Wave Analysis; D012737:Sex Factors; D012892:Sleep Deprivation / Q000503:physiopathology*; D059289:Vascular Stiffness / Q000502:physiology*