title: Extracorporeal carbon dioxide removal for refractory status asthmaticus: experience in distinct exacerbation phenotypes.
abstract: Extracorporeal carbon dioxide removal (ECCO2R) may be indicated for refractory status asthmaticus when severe dynamic hyperinflation or life-threatening respiratory acidosis persists despite optimal medical and ventilator management. Most prior reports describe the application of ECCO2R to rapid-onset asthma exacerbation, requiring a short duration of extracorporeal support. We report two patients with refractory status asthmaticus managed with ECCO2R, emphasizing the use of modern extracorporeal technology, cannulation technique and management protocols, which may improve the risk-to-benefit profile of this strategy. This report highlights the challenges in managing patients with distinct asthma exacerbation phenotypes. The potential need for prolonged device support may alter provider expectations and offers a new perspective of the role of ECCO2R for status asthmaticus.
authors.affiliation: Columbia University College of Physicians and Surgeons, Division of Pulmonary, Allergy and Critical Care, New York, USA.
authors.forename: K
authors.initials: K
authors.lastname: Brenner
authors.forename: D C
authors.initials: DC
authors.lastname: Abrams
authors.forename: C L
authors.initials: CL
authors.lastname: Agerstrand
authors.forename: D
authors.initials: D
authors.lastname: Brodie
mesh_terms: D002245:Carbon Dioxide / Q000378:metabolism*; D005112:Extracorporeal Circulation / Q000379:methods*; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013224:Status Asthmaticus / Q000628:therapy*
chemical_list: D002245:Carbon Dioxide
keywords: ECCO2R; ECMO; asthma; status asthmaticus