title: Lessons from lipids in the fight against influenza.
abstract: Influenza is a leading cause of morbidity and mortality worldwide, with vaccines and antiviral drugs having limited efficacy thus far. Two recent studies in Cell apply lipidomics approaches to identify bioactive lipid mediators influencing host inflammation, viral replication, and disease progression.
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. adolfo.garcia-sastre@mssm.edu
authors.forename: Adolfo
authors.initials: A
authors.lastname: García-Sastre
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D004281:Docosahexaenoic Acids / Q000276:immunology*; D015777:Eicosanoids / Q000302:isolation & purification*; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology*; D053122:Influenza A Virus, H3N2 Subtype / Q000502:physiology*; D053124:Influenza A Virus, H5N1 Subtype / Q000502:physiology*; D007251:Influenza, Human / Q000276:immunology*; D008055:Lipids / Q000032:analysis*; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D014779:Virus Replication
chemical_list: D015777:Eicosanoids; D005231:Fatty Acids, Unsaturated; D008055:Lipids; C495366:hydroxyoctadecadienoic acid; D004281:Docosahexaenoic Acids