title: Efficient synthesis of hydroxyl isoindolones by a Pd-mediated C-H activation/annulation reaction.
abstract: Radical reaction: A convenient synthesis of hydroxyl isoindolones by a Pd-catalyzed CH activation/annulation reaction with near "click chemistry" efficiency is presented (see scheme; TBHP=tert-butyl hydrogen peroxide). This methodology features short reaction times (10-30 min), high atom economy, wide substrate scope (22 examples), and good reaction yields (up to 93 %).
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, PR China.
authors.forename: Qingzhen
authors.initials: Q
authors.lastname: Yu
authors.forename: Nana
authors.initials: N
authors.lastname: Zhang
authors.forename: Jianhui
authors.initials: J
authors.lastname: Huang
authors.forename: Shaonan
authors.initials: S
authors.lastname: Lu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Yu
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D054833:Isoindoles / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D005609:Free Radicals; C110621:Isoindol-1-one; D054833:Isoindoles; D010165:Palladium; D002244:Carbon; D006859:Hydrogen
keywords: CH activation/annulation; heterocycles; isoindolones; palladium; radical reaction