title: Chronic norovirus infection in a transplant patient successfully treated with enterally administered immune globulin.
abstract: Norovirus infection causes a significant burden of morbidity and (in the developing world) mortality. In immunocompromised hosts, norovirus infection can become chronic, with devastating consequences. Unfortunately, therapeutic options for chronic disease are unproven, and treatment is largely supportive. We report a case of norovirus infection causing debilitating chronic gastroenteritis in a transplant patient that responded to a short course of enterally administered human immune globulin.
authors.affiliation: Department of Infectious Diseases, McMaster University, 300-25 Charlton Avenue East, Hamilton, Ontario, Canada L8N 1Y2. zain.chagla@medportal.ca
authors.forename: Zain
authors.initials: Z
authors.lastname: Chagla
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Quirt
authors.forename: Kevin
authors.initials: K
authors.lastname: Woodward
authors.forename: John
authors.initials: J
authors.lastname: Neary
authors.forename: Candace
authors.initials: C
authors.lastname: Rutherford
mesh_terms: D000284:Administration, Oral; D000914:Antibodies, Viral / Q000008:administration & dosage*; D017250:Caliciviridae Infections / Q000628:therapy* / Q000821:virology; D002908:Chronic Disease; D005260:Female; D005759:Gastroenteritis / Q000628:therapy* / Q000821:virology; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008875:Middle Aged; D029322:Norovirus / Q000302:isolation & purification*; D014180:Transplantation; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral
keywords: Chronic norovirus; Immunoglobulin; Therapy