title: ADAM8 in asthma. Friend or foe to airway inflammation?
abstract: Airway inflammation has been suggested as the pathological basis in asthma pathogenesis. Recruitment of leukocytes from the vasculature into airway sites is essential for induction of airway inflammation, a process thought to be mediated by a disintegrin and metalloprotease 8 (ADAM8). However, there is an apparent controversy about whether ADAM8 helps or hampers transmigration of leukocytes through endothelium in airway inflammation of asthma. This review outlines the current contradictory concepts concerning the role of ADAM8 in airway inflammation, particularly focusing on the recruitment of leukocytes during asthma, and attempts to bridge the existing experimental data on the basis of the functional analysis of different domains of ADAM8 and their endogenous processing in vivo. We suggest a possible hypothesis for the specific mechanism by which ADAM8 regulates the transmigration of leukocytes to explain the disparity existing in current studies, and we also raise some questions that require future investigations.
authors.affiliation: 1 Key Lab of Biorheological Science and Technology, Ministry of Education, "National 985 Project" Institute of Biorheology and Gene Regulation, Bioengineering College, Chongqing University, Chongqing, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Xuemei
authors.initials: X
authors.lastname: Jiang
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Duan
authors.forename: Jiaoyue
authors.initials: J
authors.lastname: Long
authors.forename: Jörg W
authors.initials: JW
authors.lastname: Bartsch
authors.forename: Linhong
authors.initials: L
authors.lastname: Deng
mesh_terms: D051722:ADAM Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D001249:Asthma / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000737:chemistry / Q000502:physiology; D007962:Leukocytes / Q000502:physiology; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D017434:Protein Structure, Tertiary
chemical_list: D015703:Antigens, CD; D018836:Inflammation Mediators; D008565:Membrane Proteins; D051722:ADAM Proteins; C068490:ADAM8 protein, human; C489402:Adam8 protein, mouse