title: [Efficacy, tolerance and safety of polyethylene glycol 3350 plus electrolytes for the treatment of functional constipation in children].
abstract: OBJECTIVE
  To assess the renal safety of treatment with polyethylene glycol 3350 with electrolytes at 1, 3 and 6 months, its gastrointestinal tolerance and dose effectiveness.
  
  
  METHODS
  Three groups of 30 healthy patient aged 2-10 years (mean 6.2 years) who suffered functional constipation (Rome III criteria) with 1, 3 and 6 months of treatment were evaluated. Efficacy was evaluated by the change in the number of stools per week and stool consistency (Bristol scale). Urine screens, sodium and osmolality, were performed at the beginning and after 1, 3 and 6 months of treatment. Stool sample NIRA (near-infrared reflectance analysis) and hydrogen breath test analysis samples were performed on the one-month treatment group.
  
  
  RESULTS
  The mean dose was 0.37g/kg/day (range 0.18 to 0.8) titrated according to age, weight and response. The number of stools per week during treatment (2.4±0.64) showed a significant difference (P<.001) vs (6.21±1.5) after treatment. There was also a significant difference in the Bristol scale score (1.9±0.75 vs 4.9±1.1 [P<.001]). The mean sodium intake was 112mg (5mg/kg/day [range 4-12mg/kg/day]). The values of sodium and urine osmolality were normal in all groups with no statistical difference compared to normal control values (90 healthy children without treatment). NIRA values were normal in all patients. The hydrogen breath test was normal with a median of 7ppm.
  
  
  CONCLUSIONS
  There were no adverse renal biochemical parameters or gastrointestinal disorders. Tolerance and efficacy was shown to be optimal. Polyethylene glycol 3350 with electrolytes can be safely recommended for the treatment of functional constipation in children in the short and long term.
authors.affiliation: Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital Universitario Materno-Infantil Vall d'Hebron, Barcelona, España. Electronic address: damasoinfante@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Infante Pina
authors.affiliation: Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital Universitario Materno-Infantil Vall d'Hebron, Barcelona, España.
authors.forename: O
authors.initials: O
authors.lastname: Segarra Cantón
authors.affiliation: Servicio de Nefrología Pediátrica, Hospital Universitario Materno-Infantil Vall d'Hebron, Barcelona, España.
authors.forename: R
authors.initials: R
authors.lastname: Vilalta Casas
authors.affiliation: Unidad de Gastroenterología, Servicio de Pediatría, Hospital Universitario de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Carnicer de la Pardina
authors.affiliation: Unidad de Gastroenterología, Servicio de Pediatría, Hospital de Terrassa, Terrassa, Barcelona, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: López Liñán
authors.affiliation: Unidad de Gastroenterología, Servicio de Pediatría, Parc de Salut Mar, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: C
authors.initials: C
authors.lastname: Molera Busoms
mesh_terms: D002648:Child; D002675:Child, Preschool; D003248:Constipation / Q000188:drug therapy*; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D006801:Humans; D008137:Longitudinal Studies; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000627:therapeutic use*; D011189:Potassium Chloride / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D012189:Retrospective Studies; D017693:Sodium Bicarbonate / Q000009:adverse effects / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D011092:Polyethylene Glycols; D012965:Sodium Chloride; D011189:Potassium Chloride; D017693:Sodium Bicarbonate
keywords: Constipation; Estreñimiento; Laxantes; Laxatives; Polietilenglicol 3350; Polyethylene glycol 3350; Tratamiento; Treatment