title: Nuclear factor one X regulates Bobby sox during development of the mouse forebrain.
abstract: The transcription factor nuclear factor one X (NFIX) plays a central role during the development of the neocortex and hippocampus, through the activation of astrocyte-specific gene expression and the repression of progenitor-specific pathways. However, our understanding of transcriptional targets of NFIX during cortical development remains limited. Here, we identify the transcription factor Bobby sox (Bbx) as a target for NFI-mediated transcriptional control. BBX is expressed within ventricular zone progenitor cells within the developing neocortex and hippocampus, and its expression is upregulated in Nfix (-/-) mice. Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain.
authors.affiliation: The School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors.forename: Chantelle
authors.initials: C
authors.lastname: Dixon
authors.forename: Tracey J
authors.initials: TJ
authors.lastname: Harvey
authors.forename: Aaron G
authors.initials: AG
authors.lastname: Smith
authors.forename: Richard M
authors.initials: RM
authors.lastname: Gronostajski
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Bailey
authors.forename: Michael
authors.initials: M
authors.lastname: Piper
mesh_terms: D000818:Animals; D001483:Base Sequence; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D051839:NFI Transcription Factors / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000235:genetics; D016548:Prosencephalon / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D014158:Transcription, Genetic; D015854:Up-Regulation
chemical_list: C448925:HBP2 protein; D051839:NFI Transcription Factors; C497650:Nfix protein, mouse; D015534:Trans-Activators