title: Relief of inhibitory autophosphorylation activates RAF.
abstract: RAF inhibitors paradoxically activate wild-type RAF by blocking inhibitory autophosphorylation.
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D020935:MAP Kinase Signaling System / Q000235:genetics*; D008545:Melanoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D009154:Mutation; D010766:Phosphorylation; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D019908:Proto-Oncogene Proteins c-raf / Q000235:genetics* / Q000378:metabolism
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D019908:Proto-Oncogene Proteins c-raf