title: Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent.
abstract: BACKGROUND
  Cervical clear cell carcinoma is one of the rare subtypes of cervical adenocarcinomas. Few cases of cervical clear cell carcinoma have been reported in adolescents.
  
  
  METHODS
  We present here a case of a 14-year-old adolescent female diagnosed with a stage II cervical clear cell carcinoma. The patient had no sexual history or diethylstilbestrol-exposure in utero. Polymerase chain reaction identified in the tumor the presence of human papillomavirus type 18, a high-risk genotype for cervical cancer development. The ovaries were retained during surgery and the patient was still alive without recurrence after 9 years.
  
  
  CONCLUSIONS
  Positivity of HPV18 nucleic acids suggests an association between high risk HPV infection and cervical clear cell carcinoma in the case. Furthermore, in the treatment of young patients with cervical carcinoma, the risks associated with loss of ovarian function should be weighed against that of potential ovarian metastasis.
authors.affiliation: Department of Obstetrics and Gynaecology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Obstetrics and Gynaecology, Chinese PLA General Hospital, Beijing, China. Electronic address: songl301@hotmail.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Tumor-Associated Virus, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Key Laboratory of Medical Virology, Ministry of Health, China. Electronic address: liuht@chinacdc.cn.
authors.forename: Hongtu
authors.initials: H
authors.lastname: Liu
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000628:therapy* / Q000821:virology*; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage; D016461:Chemoembolization, Therapeutic; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D006801:Humans; D007044:Hysterectomy; D002583:Uterine Cervical Neoplasms / Q000628:therapy* / Q000821:virology*
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D016190:Carboplatin; C027260:pirarubicin
keywords: Adenocarcinoma; Adolescent; Cervical carcinoma; Human papillomavirus