title: Impact of environmental factors on efficacy of glucocorticoids in Chinese population with systemic lupus erythematosus.
abstract: Although glucocorticoids (GCs) are effective in inducing remission in systemic lupus erythematosus (SLE) patients, there is a significant variation in response to therapeutic GCs, and some patients do not achieve full remission. The aim of this study was to explore the impact of environmental factors on the efficacy of GCs in a Chinese population with SLE. This was a prospective cohort study, and a total of 260 SLE patients treated with GCs (prednisone) were followed up for 12 weeks. The efficacy of GCs was measured with the scores on SLE disease activity index. Environmental factors were collected using a questionnaire. Single-variable analysis and multivariate logistic regression analysis were used to discriminate the impact of environmental factors on the efficacy of GCs. Two hundred forty-seven patients (95.00 %) completed the 12-week follow-up. Among these patients, 131 (53.04 %) were classified into sensitive group and 116 (46.96 %) were classified into insensitive group. Results from logistic analysis showed that the following environmental factors were significantly associated with decreased efficacy of GCs: high salt intake (OR = 3.464, 95%CI = 1.481-8.102, P = 0.004), introverted personality (OR = 3.550, 95%CI = 1.901-6.628, P < 0.0001), experience with negative life events (OR = 5.526, 95%CI = 1.612-18.946, P = 0.007), and history of allergy (OR = 2.966, 95%CI = 1.312-6.704, P = 0.009). These results indicate that environmental factors, including salt intake, personality, experience with negative life events, and history of allergy, may play an important role in the efficacy of GCs in the Chinese population with SLE.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, , Anhui, China.
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Zou
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xu
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Tao
authors.forename: Sheng-Qian
authors.initials: SQ
authors.lastname: Xu
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Shan-Yu
authors.initials: SY
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Cai
authors.forename: Li
authors.initials: L
authors.lastname: Lian
authors.forename: Pei-Ling
authors.initials: PL
authors.lastname: Chen
authors.forename: De-Guang
authors.initials: DG
authors.lastname: Wang
authors.forename: Sheng-Xiu
authors.initials: SX
authors.lastname: Liu
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Liang
authors.forename: Qian-Ling
authors.initials: QL
authors.lastname: Ye
authors.forename: Guo
authors.initials: G
authors.lastname: Tian
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Fa-Ming
authors.initials: FM
authors.lastname: Pan
authors.forename: Hong
authors.initials: H
authors.lastname: Su
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000328:Adult; D002681:China; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D006967:Hypersensitivity; D008016:Life Change Events; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008297:Male; D010551:Personality; D011241:Prednisone / Q000627:therapeutic use*; D011446:Prospective Studies; D012965:Sodium Chloride; D011795:Surveys and Questionnaires
chemical_list: D005938:Glucocorticoids; D012965:Sodium Chloride; D011241:Prednisone