title: Perfusion studies in senology.
abstract: Microcirculation imaging in breast cancer involves studying tissue enhancement after contrast injection, which is used to calculate perfusion and permeability. The magnitude of enhancement reflects blood and interstitial volumes. This technique has benefitted from advances in MRI, which allow large volumes to be acquired with a good compromise between temporal and spatial resolution. Software has also advanced enabling microcirculation maps to be calculated and heterogeneity to be analyzed. If permeability is increased and interstitial volume is reduced, the microcirculation imaging suggests a suspicious aggressive lesion and can be used for early assessment of neoadjuvant therapies by demonstrating restoration of normal functional indices, which precede morphological changes.
authors.affiliation: Department of Radiology, Saint-Louis Hospital, Inserm Unit U728, Paris VII University, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: Cedric.de-bazelaire@sls.aphp.fr.
authors.forename: C
authors.initials: C
authors.lastname: de Bazelaire
authors.forename: A
authors.initials: A
authors.lastname: Scémama
authors.forename: A
authors.initials: A
authors.lastname: Coffin
authors.forename: S
authors.initials: S
authors.lastname: Cohen
authors.forename: M
authors.initials: M
authors.lastname: Chapellier
authors.forename: F
authors.initials: F
authors.lastname: Sabatier
authors.forename: M
authors.initials: M
authors.lastname: Albiter
authors.forename: E
authors.initials: E
authors.lastname: de Kerviler
mesh_terms: D001943:Breast Neoplasms / Q000098:blood supply* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008833:Microcirculation; D055420:Perfusion Imaging / Q000379:methods*
keywords: Breast; Cancer; Functional MRI; Histological prognosis; Microcirculation