title: Pathogenesis of exercise-induced bronchoconstriction.
abstract: This article presents the various potential mechanisms responsible for the development of exercise-induced bronchoconstriction (EIB). Although the etiology of EIB is multifactorial, and the physiologic processes involved may vary between individuals (especially between those with and without asthma), drying of the small airways with an associated inflammatory response seems prerequisite for EIB. Dysregulated repair processes following exercise-induced airway epithelial injury may also serve as basis for EIB development/progression.
authors.affiliation: Centre for Sports Medicine & Human Performance, Brunel University, Uxbridge, Middlesex UB8 3PH, UK. pascale.kippelen@brunel.ac.uk
authors.forename: Pascale
authors.initials: P
authors.lastname: Kippelen
authors.forename: Sandra D
authors.initials: SD
authors.lastname: Anderson
mesh_terms: D001250:Asthma, Exercise-Induced / Q000209:etiology*; D006801:Humans; D020545:Respiratory Mucosa / Q000294:innervation / Q000378:metabolism / Q000473:pathology; D013312:Stress, Physiological; D013696:Temperature
keywords: Airway inflammation; Epithelial injury; Hyperpnoea; Osmotic stress; Thermal stress