title: Effect of maternal use of labetalol on the cerebral autoregulation in premature infants.
abstract: Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and rScO2 by means of correlation, coherence, and transfer function analysis. We found that these infants presented higher values of transfer function gain, which indicates impaired cerebral autoregulation, with a decreasing trend towards normality. We hypothesised that this trend was due to a vasodilation effect of the maternal use of labetalol due to accumulation, which disappeared by the third day after birth. Therefore, we investigated the values of pulse pressure in order to find evidence for a vasodilatory effect. We found that lower values of pulse pressure were present in these infants when compared with a control population, which, together with increased transfer function gain values, suggests an effect of the drug on the cerebral autoregulation.
authors.affiliation: Department of Electrical Engineering, ESAT/SCD, KU Leuven, Leuven, Belgium. acaicedo@esat.kuleuven.be.|iMinds Future Health Department, Leuven, Belgium. acaicedo@esat.kuleuven.be.
authors.forename: Alexander
authors.initials: A
authors.lastname: Caicedo
authors.affiliation: Neonatal Intensive Care Unit, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Thewissen
authors.affiliation: Neonatal Intensive Care Unit, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Naulaers
authors.affiliation: Department of Neonatology, University Medical Center, Wilhelmina Children's Hospital, Utrecht, The Netherlands.
authors.forename: Petra
authors.initials: P
authors.lastname: Lemmers
authors.affiliation: Department of Neonatology, University Medical Center, Wilhelmina Children's Hospital, Utrecht, The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: van Bel
authors.affiliation: Department of Electrical Engineering, ESAT/SCD, KU Leuven, Leuven, Belgium.|iMinds Future Health Department, Leuven, Belgium.
authors.forename: Sabine
authors.initials: S
authors.lastname: Van Huffel
mesh_terms: D062186:Arterial Pressure / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D054022:Cerebrum / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000188:drug therapy / Q000378:metabolism; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007741:Labetalol / Q000627:therapeutic use*; D009034:Mother-Child Relations; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy* / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
chemical_list: D007741:Labetalol