title: Facial basal cell carcinoma with successive metastases to the neck, thyroid gland and lung.
abstract: Basal cell carcinoma of the skin is the most common malignancy in the head and neck area. Regional and distant metastases rarely occur with this type of tumour. We report an uncommon case of a sclerodermiform basal cell carcinoma of the facial skin in which metastases developed several years after the primary tumour. The metastases occurred in the soft tissue of the neck, the thyroid gland and the lung. This is the first case of BCC with triple metastases which were histologically confirmed.
authors.affiliation: Department of Oral, Maxillofacial and Facial Plastic Surgery (Head: Prof. Robert Mischkowski), Ludwigshafen Hospital, Bremserstrasse 79, 67063 Ludwigshafen am Rhein, Germany. Electronic address: thieleo@klilu.de.
authors.forename: Oliver C
authors.initials: OC
authors.lastname: Thiele
authors.affiliation: Department of Oral and Maxillofacial Surgery (Head: Prof. Jürgen Hoffmann), University Hospital Heidelberg, INF 400, Heidelberg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Mertens
authors.affiliation: Department of Human Genetics (Head: Prof. Gudrun Rappold), Molecular Genetics Division, University Hospital Heidelberg, INF 366, Heidelberg, Germany.
authors.forename: Claire
authors.initials: C
authors.lastname: Bacon
authors.affiliation: Institute of Pathology (Head: Prof. Peter Schirmacher), University Hospital Heidelberg, INF 224, Heidelberg, Germany.
authors.forename: Christa
authors.initials: C
authors.lastname: Flechtenmacher
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery (Head: Prof. Peter Plinkert), University Hospital Heidelberg, INF 400, Heidelberg, Germany.
authors.forename: Karim
authors.initials: K
authors.lastname: Zaoui
authors.affiliation: Department of Oral, Maxillofacial and Facial Plastic Surgery (Head: Prof. Robert Mischkowski), Ludwigshafen Hospital, Bremserstrasse 79, 67063 Ludwigshafen am Rhein, Germany.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Mischkowski
mesh_terms: D002280:Basal Cell Carcinoma / Q000473:pathology / Q000556:secondary*; D005153:Facial Neoplasms / Q000473:pathology*; D017809:Fatal Outcome; D006258:Head and Neck Neoplasms / Q000556:secondary; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000556:secondary; D013964:Thyroid Neoplasms / Q000556:secondary
keywords: Basal cell carcinoma; Head and neck cancer; Metastasis; Oral and maxillofacial surgery