title: Special article: the endothelial glycocalyx: emerging concepts in pulmonary edema and acute lung injury.
abstract: The endothelial glycocalyx is a dynamic layer of macromolecules at the luminal surface of vascular endothelium that is involved in fluid homeostasis and regulation. Its role in vascular permeability and edema formation is emerging but is still not well understood. In this special article, we highlight key concepts of endothelial dysfunction with regards to the glycocalyx and provide new insights into the glycocalyx as a mediator of processes central to the development of pulmonary edema and lung injury.
authors.affiliation: From the Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia; Department of Anesthesiology, University of Utah, Salt Lake City, Utah; and Department of Anesthesiology and Bioengineering, University of Illinois at Chicago College of Medicine, Chicago, Illinois.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Collins
authors.forename: Randal S
authors.initials: RS
authors.lastname: Blank
authors.forename: Lindy S
authors.initials: LS
authors.lastname: Deatherage
authors.forename: Randal O
authors.initials: RO
authors.lastname: Dull
mesh_terms: D055371:Acute Lung Injury / Q000473:pathology*; D000465:Algorithms; D002199:Capillary Permeability / Q000502:physiology; D004727:Endothelium / Q000473:pathology*; D019276:Glycocalyx / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000601:surgery; D040542:Mechanotransduction, Cellular; D011654:Pulmonary Edema / Q000473:pathology*