title: Innate immunity and neuroinflammation.
abstract: Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful. Innate immune system consisting of pattern-recognition receptors, macrophages, and complement system plays a key role in CNS homeostasis following injury and infection. Here, we discuss how innate immune components can also contribute to neuroinflammation and neurodegeneration.
authors.affiliation: Centre for Infection, Immunity and Disease Mechanisms, Heinz Wolff Building, Brunel University, London UB8 3PH, UK.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Shastri
authors.forename: Domenico Marco
authors.initials: DM
authors.lastname: Bonifati
authors.forename: Uday
authors.initials: U
authors.lastname: Kishore
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000473:pathology; D002490:Central Nervous System / Q000473:pathology; D003165:Complement System Proteins / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D008024:Ligands; D017628:Microglia / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D008024:Ligands; D051193:Toll-Like Receptors; D003165:Complement System Proteins