title: Betulin-betulinic acid natural product based analogs as anti-cancer agents.
abstract: Herein we describe a brief account of betulin and betulinic acid: two natural products isolated from birch bark, their chemical modifications and further biological/medicinal applications.
authors.forename: Subash C
authors.initials: SC
authors.lastname: Jonnalagadda
authors.forename: Michael A
authors.initials: MA
authors.lastname: Corsello
authors.affiliation: Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA. jonnalagadda@rowan.edu.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Sleet
mesh_terms: D000588:Amines / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029662:Betula / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004952:Esters; D006801:Humans; D007093:Imidazoles / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D053978:Pentacyclic Triterpenes; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D000588:Amines; D000972:Antineoplastic Agents, Phytogenic; D002219:Carbamates; D004952:Esters; D007093:Imidazoles; D009570:Nitriles; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014230:Triazoles; D014315:Triterpenes; C002503:betulin; D000094062:Betulinic Acid