title: [Treatment of refractory depression patients of yin deficiency inner heat syndrome by jieyu granule combined paroxetine: an efficacy observation].
abstract: OBJECTIVE
  To explore the efficacy of jieyu granule (JG) combined Paroxetine in treating refractory depression (RD) patients of yin deficiency inner heat syndrome (YDIHS).
  
  
  METHODS
  Seventy RD patients of YDIHS were randomly assigned to the experimental group (JG combined Paroxetine) and the control group (Chinese medical placebo combined Paroxetine), 35 cases in each group. Hamilt Depression Rating Scale and Hamilton Anxiety Scale were used before treatment, and at the weekend of the 2nd, 4th, and 8th week, respectively.
  
  
  RESULTS
  In the experimental group, 32 patients completed the trial and 3 patients dropped out. In the control group, 33 patients completed the trial and 2 patients dropped out. At the end of the 8th week of the treatment, the total score of Hamilt Depression Rating Scale was (14.75 +/- 7.85) in the experimental group, lower than that of the control group (19. 06 +/- 8. 31, P <0.05). At the end of the 2nd, 4th, and 8th week of the treatment, the score of Hamilton Anxiety Scale was 17.03 +/- 4.25, 14.50 +/- 5. 13, and 11.03 +/- 4.88, respectively in the experimental group, lower than that of the control group at each corresponding time point (19. 60 +/-3. 96, 17. 12 +/- 4.14, 14.64 +/- 4.47, P <0.05, P <0.01).
  
  
  CONCLUSIONS
  The efficacy of JG combined Paroxetine for treating RD patients of YDIHS was superior to that of using Paroxetine alone.
authors.affiliation: Beijing Anding Hospital, Capital Medical University, Beijing 10088, China;
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Hong-xiao
authors.initials: HX
authors.lastname: Jia
authors.forename: Jian-qin
authors.initials: JQ
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.forename: Jin-zhou
authors.initials: JZ
authors.lastname: Tian
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D061218:Depressive Disorder, Treatment-Resistant / Q000175:diagnosis / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000627:therapeutic use*; D008517:Phytotherapy; D016896:Treatment Outcome; D016710:Yin Deficiency / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D004365:Drugs, Chinese Herbal; D017374:Paroxetine