title: Cardiovascular disease risk in adults with spastic bilateral cerebral palsy.
abstract: OBJECTIVE
  To explore: (i) cardiovascular disease risk factors and the 10-year clustered risk of a fatal cardiovascular event in adults with spastic bilateral cerebral palsy; and (ii) relationships between the 10-year risk and body fat, aerobic fitness and physical activity.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Forty-three adults with spastic bilateral cerebral palsy without severe cognitive impairment (mean age 36.6 years (standard deviation 6); 27 men).
  
  
  METHODS
  Biological and lifestyle-related risk factors and the 10-year risk according to the Systematic Coronary Risk Evaluation (SCORE) were assessed. Relationships were studied using multivariable linear regression analysis.
  
  
  RESULTS
  The following single risk factors were present: hypertension (n = 12), elevated total cholesterol (n = 3), low high-density lipoprotein cholesterol (n = 5; all men), high-risk waist circumference (n = 11), obesity (body mass index; n = 5; all men), reduced aerobic fitness (on average 80% of reference values), reduced level of everyday physical activity (on average 78% of reference values) and smoking (n=9). All participants had a 10-year risk <1%. Corrected for gender, participants with higher waist circumference (β = 0.28; p = 0.06) or body mass index (β=0.25; p = 0.08) tended to have a higher 10-year risk.
  
  
  CONCLUSIONS
  In this relatively young adult sample of people with spastic bilateral cerebral palsy several single cardiovascular disease risk factors were present. The 10-year fatal cardiovascular disease risk was low, and higher body fat tended to be related to higher 10-year risk.
authors.affiliation: Rijndam Rehabilitation Centre Westersingel 300, NL-3015 LJ Rotterdam, The Netherlands. w.vanderslot@erasmusmc.nl.
authors.forename: Wilma M A
authors.initials: WM
authors.lastname: van der Slot
authors.forename: Marij E
authors.initials: ME
authors.lastname: Roebroeck
authors.forename: Channah
authors.initials: C
authors.lastname: Nieuwenhuijsen
authors.forename: Michael P
authors.initials: MP
authors.lastname: Bergen
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Stam
authors.forename: Alex
authors.initials: A
authors.lastname: Burdorf
authors.forename: Rita J G
authors.initials: RJ
authors.lastname: van den Berg-Emons
mesh_terms: D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000150:complications* / Q000401:mortality*; D002547:Cerebral Palsy / Q000150:complications / Q000503:physiopathology; D003430:Cross-Sectional Studies; D050171:Dyslipidemias; D005080:Exercise Test; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009128:Muscle Spasticity / Q000209:etiology; D009765:Obesity; D010809:Physical Fitness; D012307:Risk Factors; D012907:Smoking; D055105:Waist Circumference