title: mRMRe: an R package for parallelized mRMR ensemble feature selection.
abstract: BACKGROUND
  Feature selection is one of the main challenges in analyzing high-throughput genomic data. Minimum redundancy maximum relevance (mRMR) is a particularly fast feature selection method for finding a set of both relevant and complementary features. Here we describe the mRMRe R package, in which the mRMR technique is extended by using an ensemble approach to better explore the feature space and build more robust predictors. To deal with the computational complexity of the ensemble approach, the main functions of the package are implemented and parallelized in C using the openMP Application Programming Interface.
  
  
  RESULTS
  Our ensemble mRMR implementations outperform the classical mRMR approach in terms of prediction accuracy. They identify genes more relevant to the biological context and may lead to richer biological interpretations. The parallelized functions included in the package show significant gains in terms of run-time speed when compared with previously released packages.
  
  
  BACKGROUND
  The R package mRMRe is available on Comprehensive R Archive Network and is provided open source under the Artistic-2.0 License. The code used to generate all the results reported in this application note is available from Supplementary File 1.
  
  
  BACKGROUND
  bhaibeka@ircm.qc.ca
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Bioinformatics and Computational Biology Laboratory, Integrative Systems Biology Axis, Institut de recherches cliniques de Montréal, Montreal, H2W 1R7, Quebec, Canada.
authors.forename: Nicolas
authors.initials: N
authors.lastname: De Jay
authors.forename: Simon
authors.initials: S
authors.lastname: Papillon-Cavanagh
authors.forename: Catharina
authors.initials: C
authors.lastname: Olsen
authors.forename: Nehme
authors.initials: N
authors.lastname: El-Hachem
authors.forename: Gianluca
authors.initials: G
authors.lastname: Bontempi
authors.forename: Benjamin
authors.initials: B
authors.lastname: Haibe-Kains
mesh_terms: D000465:Algorithms; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002166:Camptothecin / Q000031:analogs & derivatives / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D023281:Genomics / Q000379:methods*; D000077146:Irinotecan; D012984:Software
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin