title: Organs-on-a-chip for drug discovery.
abstract: The current drug discovery process is arduous and costly, and a majority of the drug candidates entering clinical trials fail to make it to the marketplace. The standard static well culture approaches, although useful, do not fully capture the intricate in vivo environment. By merging the advances in microfluidics with microfabrication technologies, novel platforms are being introduced that lead to the creation of organ functions on a single chip. Within these platforms, microengineering enables precise control over the cellular microenvironment, whereas microfluidics provides an ability to perfuse the constructs on a chip and to connect individual sections with each other. This approach results in microsystems that may better represent the in vivo environment. These organ-on-a-chip platforms can be utilized for developing disease models as well as for conducting drug testing studies. In this article, we highlight several key developments in these microscale platforms for drug discovery applications.
authors.affiliation: Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Seila
authors.initials: S
authors.lastname: Selimović
authors.forename: Mehmet R
authors.initials: MR
authors.lastname: Dokmeci
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D018929:Cell Culture Techniques; D055808:Drug Discovery; D006321:Heart; D006801:Humans; D007422:Intestines; D008168:Lung; D023822:Tissue Engineering / Q000379:methods*