title: Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering.
abstract: This study investigated the effect of the addition of sol-gel derived nanoscale bioactive glass (NBG) particles on the mechanical properties and biological performances of PCL polymer, in order to evaluate the potential applications of PCL/NBG composites for bone tissue regeneration. Regardless of the NBG contents (10, 20, and 30 wt.%), the NBG particles, which were synthesized through the sol-gel process using polyethylene glycol (PEG) polymer as a template, could be uniformly dispersed in the PCL matrix, while generating pores in the PCL/NBG composites. The elastic modulus of the PCL/NBG composites increased remarkably from 89±11 MPa to 383±50 MPa with increasing NBG content from 0 to 30 wt.%, while still showing good ultimate tensile strength in the range of 15-19 MPa. The hydrophilicity, water absorption and degradation behavior of the PCL/NBG composites were also enhanced by the addition of the NBG particles. Furthermore, the PCL/NBG composite with a NBG content of 30 wt.% showed significantly enhanced in vitro bioactivity and cellular response compared to those of the pure PCL.
authors.affiliation: Department of Dental Laboratory Science and Engineering, Korea University, Seoul, 136-703, Republic of Korea.
authors.forename: Bo
authors.initials: B
authors.lastname: Lei
authors.forename: Kwan-Ha
authors.initials: KH
authors.lastname: Shin
authors.forename: Da-Young
authors.initials: DY
authors.lastname: Noh
authors.forename: In-Hwan
authors.initials: IH
authors.lastname: Jo
authors.forename: Young-Hag
authors.initials: YH
authors.lastname: Koh
authors.forename: Hyoun-Ee
authors.initials: HE
authors.lastname: Kim
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Kim
mesh_terms: D000327:Adsorption; D000818:Animals; D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects*; D055119:Elastic Modulus / Q000187:drug effects; D005898:Glass / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions / Q000187:drug effects; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D010316:Particle Size; D044367:Phase Transition / Q000187:drug effects*; D011091:Polyesters / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D013718:Tensile Strength / Q000187:drug effects; D023822:Tissue Engineering / Q000379:methods*; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D011091:Polyesters; D014867:Water; C016240:polycaprolactone
keywords: Bioactive glass; Biodegradation; Composite; Hard tissue; Mechanical properties; Polymer