title: Newly described pattern recognition receptors team up against intracellular pathogens.
abstract: Recognizing the presence of invading pathogens is key to mounting an effective innate immune response. Mammalian cells express different classes of germline-encoded pattern recognition receptors that monitor the extracellular and intracellular compartments of host cells for signs of infection and that activate several conserved signalling pathways. An efficient immune response often requires the sequential detection of a pathogen by different receptors in different subcellular compartments, which results in a complex interplay of downstream signalling pathways. In this Review, we discuss the recent identification of previously unknown pattern recognition receptors and how they complement the repertoire of established receptors.
authors.affiliation: Focal Area Infection Biology, Biozentrum, University of Basel, Switzerland.
authors.forename: Petr
authors.initials: P
authors.lastname: Broz
authors.forename: Denise M
authors.initials: DM
authors.lastname: Monack
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology* / Q000473:pathology; D053487:DEAD-box RNA Helicases / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D009687:Nuclear Proteins / Q000276:immunology; D010750:Phosphoproteins / Q000276:immunology; D016601:RNA-Binding Proteins / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology; D000099197:STING Protein
chemical_list: D053487:DEAD-box RNA Helicases; D058847:Inflammasomes; D008565:Membrane Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors; C114370:LRRFIP1 protein, human; C532857:STING1 protein, human; D000099197:STING Protein; C076700:IFI16 protein, human; C501226:DDX41 protein, human