title: CMOS low current measurement system for biomedical applications.
abstract: We present a micro-chip implementation of a low current measurement system for biomedical applications using capacitive feedback that exhibits 190 fA of RMS noise in a 1 kHz bandwidth. The sampling rate is selectable up to 100 kHz. When measuring the amplifier noise with a 10 GΩ resistor and a 47 pF capacitor at the input, typical of cell membrane capacitance in DNA and patch clamp experiments, the measured RMS noise was 2.44 pA on a 50 pA signal in a 10 kHz bandwidth. Two channels were implemented on 630 × 440 μm² using a 0.5-μm 3-metal 2-poly CMOS process. Each channel consumes 1.5 mW of power from a 3.3 V supply. We measured the characteristics of an artificial lipid bilayer similar to the ones used in DNA sequencing experiments via nanopores.
authors.affiliation: Department of Electrical Engineering, Yale University, New Haven, CT 06520, USA. brian.goldstein@yale.edu
authors.forename: Brian
authors.initials: B
authors.lastname: Goldstein
authors.forename: Dongsoo
authors.initials: D
authors.lastname: Kim
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: T Kyle
authors.initials: TK
authors.lastname: Vanderlick
authors.forename: Eugenio
authors.initials: E
authors.lastname: Culurciello
mesh_terms: D000669:Amplifiers, Electronic; D020811:Biomedical Technology / Q000295:instrumentation* / Q000379:methods*; D004560:Electricity; D055724:Electrophysiological Phenomena; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D012666:Semiconductors
chemical_list: D008051:Lipid Bilayers; D008670:Metals; D010087:Oxides