title: Epithelial membrane protein 2 is a prognostic indictor for patients with urothelial carcinoma of the upper urinary tract.
abstract: Upper urinary tract urothelial carcinoma is a relatively uncommon disease and is diagnosed more frequently at advanced stages. The prognosis of these patients mainly has been related to tumor stage and grade. As a result, the definition of prognostic indicators enabling precise patient selection is mandatory for neoadjuvant or adjuvant therapies. The epithelial membrane protein (EMP2) was identified as one of the up-regulated genes by isoflavones. EMP2 overexpression suppressed foci formation, anchorage-independent growth in vitro, and tumorigenicity in severe combined immunodeficiency mice (all P < 0.05). In addition, a cross-talk between EMP2 and integrins αV and β3 was shown in the regulation of cell adhesion and migration. Higher EMP2 expression was associated with a better progression-free survival (P = 0.008) and cancer-related death (P < 0.001). EMP2 was identified as a tumor-suppressor gene in urinary tract urothelial carcinoma and may be an innovative co-targeting candidate for designing integrin-based cancer therapy.
authors.affiliation: Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Wang
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Li
authors.forename: Wen-Jeng
authors.initials: WJ
authors.lastname: Wu
authors.forename: Chee-Yin
authors.initials: CY
authors.lastname: Chai
authors.forename: Tsuey-Yu
authors.initials: TY
authors.lastname: Chang
authors.forename: Yin
authors.initials: Y
authors.lastname: Sun
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Cheng
authors.forename: Yow-Ling
authors.initials: YL
authors.lastname: Shiue
authors.forename: Shu-Jem
authors.initials: SJ
authors.lastname: Su
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Cheng
authors.forename: Hsiao-Sheng
authors.initials: HS
authors.lastname: Liu
authors.forename: Nan-Haw
authors.initials: NH
authors.lastname: Chow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D063646:Carcinogenesis / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D057809:HEK293 Cells; D006801:Humans; D016023:Integrins / Q000378:metabolism; D007529:Isoflavones / Q000494:pharmacology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D021381:Protein Transport / Q000187:drug effects; D014571:Urologic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D019459:Urothelium / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: C486403:EMP2 protein, human; D016023:Integrins; D007529:Isoflavones; D008562:Membrane Glycoproteins