title: Importance of lipid microdomains, rafts, in absorption, delivery, and biological effects of resveratrol.
abstract: The preventive effects of the phytoalexin trans-resveratrol toward cancer have been largely described at the cellular and molecular levels in both in vivo and in vitro models; however, its primary targets are still poorly identified. In this review, we show the crucial role of cell membrane microdomains, that is, lipid rafts, not solely in the initiation of the early biochemical events triggered by resveratrol leading to cancer cell death, but also in resveratrol absorption and distribution. Resveratrol accumulates in lipid rafts and is then taken up by cells through raft-dependent endocytosis. These events allow early activation of kinase pathways and redistribution of cell death receptors within lipid microdomains, events ultimately leading to apoptotic cell death.
authors.affiliation: University of Burgundy, Dijon, France. ddelmas@u-bourgogne.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Delmas
authors.forename: Virginie
authors.initials: V
authors.lastname: Aires
authors.forename: Didier J
authors.initials: DJ
authors.lastname: Colin
authors.forename: Emeric
authors.initials: E
authors.lastname: Limagne
authors.forename: Alessandra
authors.initials: A
authors.lastname: Scagliarini
authors.forename: Alexia K
authors.initials: AK
authors.lastname: Cotte
authors.forename: François
authors.initials: F
authors.lastname: Ghiringhelli
mesh_terms: D000042:Absorption / Q000187:drug effects / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects* / Q000502:physiology; D021962:Membrane Microdomains / Q000187:drug effects* / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
keywords: apoptosis; cancer; rafts; resveratrol; transport