title: Efficacy of ceftaroline fosamil against penicillin-sensitive and -resistant streptococcus pneumoniae in an experimental rabbit meningitis model.
abstract: Ceftaroline is a new cephalosporin with bactericidal activity against resistant Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae, as well as common Gram-negative organisms. This study tested the prodrug, ceftaroline fosamil, against a penicillin-sensitive and a penicillin-resistant strain of S. pneumoniae in an experimental rabbit meningitis model. The penetration of ceftaroline into inflamed meninges was approximately 14%. Ceftaroline fosamil was slightly superior to ceftriaxone against the penicillin-sensitive strain and significantly superior to the combination of ceftriaxone and vancomycin against the penicillin-resistant strain.
authors.affiliation: Clinic of Internal Medicine, Clinic Sonnenhof, Bern, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Cottagnoud
authors.forename: M
authors.initials: M
authors.lastname: Cottagnoud
authors.forename: F
authors.initials: F
authors.lastname: Acosta
authors.forename: A
authors.initials: A
authors.lastname: Stucki
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000627:therapeutic use*; D008581:Meningitis / Q000188:drug therapy*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000472:pathogenicity*; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D000097583:Ceftaroline