title: Teduglutide in Crohn's disease.
abstract: BACKGROUND
  The currently available medications for treatment of Crohn's disease (CD) include aminosalicylates, corticosteroids, antibiotics, immunomodulators and biologic agents (infliximab, certolizumab pegol, adalimumab and natalizumab). These agents target the immune and inflammatory pathways of CD, while there is a shortage of agents that target the barrier functions of the gut that are impaired in CD. Glucagon-like peptide 2 is an enterogastrone with strong trophic effects on the intestinal mucosa. Teduglutide , the analog of glucagon-like peptide has been already approved by the US Food and Drug Administration as a treatment of short bowel syndrome. This review discusses the potential use of teduglutide in patients with CD.
  
  
  METHODS
  As there has been only one randomized placebo controlled trial of teduglutide in CD, there is a shortage of data regarding the efficacy of this agent in CD. The literature search was performed using Medline database with the use of the following key words: teduglutide, glucagon-like peptide-2, CD and inflammatory bowel disease.
  
  
  CONCLUSIONS
  Based on available data, it can be concluded that this agent seems to be a promising medication in CD and further trials are required to define the place of teduglutide in treatment of CD.
authors.affiliation: United Health Services, Johnson City, NY 13790, USA.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Blonski
authors.forename: Anna M
authors.initials: AM
authors.lastname: Buchner
authors.forename: Faten
authors.initials: F
authors.lastname: Aberra
authors.forename: Gary
authors.initials: G
authors.lastname: Lichtenstein
mesh_terms: D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D003424:Crohn Disease / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D039441:Integrin alpha4 / Q000737:chemistry*; D000069442:Natalizumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000069442:Natalizumab; D039441:Integrin alpha4