title: [Intrahepatic cholestasis of pregnancy and fetal injury].
abstract: Intrahepatic cholestasis of pregnancy (ICP) is an unique complication in pregnancy, which usually manifests in the second or third trimester, and mainly harms the fetus. Its pathogenesis is not yet clear, and placental pathological changes are insufficient to explain the clinical phenomenon.Recent studies had shown that the important cause of perinatal deaths may be the damage to the placental structure and function caused by the high bile acid level. In addition, the change of placental structure and function, umbilical cord factors, and endocrine changes can also cause the fetal development and intrauterine hypoxia. In recent years related researches focus on the toxic effect of bile acid on fetus heart, lungs, brain, liver, and other important organs, the placental vascular pathology, hemodynamic changes, umbilical cord blood vessel factors and the endocrine changes.
authors.affiliation: Department of Obstetrics and Gynecology, Central South University, Changsha, China. zlj621116@sina.com
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhang
authors.forename: Fenghua
authors.initials: F
authors.lastname: Zhang
authors.forename: Lili
authors.initials: L
authors.lastname: Tang
authors.forename: Weihong
authors.initials: W
authors.lastname: Yang
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism*; D002780:Cholestasis, Intrahepatic / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000209:etiology* / Q000378:metabolism; D005333:Fetus / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism* / Q000473:pathology; D014470:Umbilical Cord / Q000378:metabolism / Q000473:pathology*
chemical_list: D001647:Bile Acids and Salts