title: Capillary zone electrophoresis for separation and quantitative determination of mexiletine and its main phase I metabolites.
abstract: The simultaneous separation and quantification of the analytes within the minimum analysis time and the maximum resolution and efficiency are the main objectives in the development of a capillary electrophoretic method for the determination of solutes. In this paper we describe a specific, sensitive and robust method, using capillary zone electrophoresis with internal standard and UV detection, for the separation and quantification of the anti-arrhythmic drug mexiletine, its main phase I metabolites, and its main nitrogenous degradation product.
authors.forename: Claudio
authors.initials: C
authors.lastname: Bruno
authors.forename: Maria Maddalena
authors.initials: MM
authors.lastname: Cavalluzzi
authors.forename: Alessia
authors.initials: A
authors.lastname: Carocci
authors.forename: Alessia
authors.initials: A
authors.lastname: Catalano
authors.forename: Carlo
authors.initials: C
authors.lastname: Franchini
authors.affiliation: Dipartimento di Farmacia- Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via Orabona 4, 70126 Bari, Italy. alessia.catalano@uniba.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lentini
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000302:isolation & purification* / Q000493:pharmacokinetics*; D001711:Biotransformation; D002384:Catalysis; D003500:Cyclization; D019075:Electrophoresis, Capillary / Q000379:methods*; D007202:Indicators and Reagents; D008801:Mexiletine / Q000302:isolation & purification* / Q000493:pharmacokinetics*; D012015:Reference Standards; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000889:Anti-Arrhythmia Agents; D007202:Indicators and Reagents; D008801:Mexiletine