title: Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.
abstract: The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p=0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.
authors.affiliation: Centre Hospitalier Universitaire, Rouen, France; Université de Rouen, France. Valerie.delbos@chu-rouen.fr
authors.forename: Valérie
authors.initials: V
authors.lastname: Delbos
authors.forename: Ludovic
authors.initials: L
authors.lastname: Lemée
authors.forename: Jacques
authors.initials: J
authors.lastname: Bénichou
authors.forename: Gilles
authors.initials: G
authors.lastname: Berthelot
authors.forename: Ala-Eddine
authors.initials: AE
authors.lastname: Deghmane
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Leroy
authors.forename: Estelle
authors.initials: E
authors.lastname: Houivet
authors.forename: Eva
authors.initials: E
authors.lastname: Hong
authors.forename: Muhamed-Kheir
authors.initials: MK
authors.lastname: Taha
authors.forename: François
authors.initials: F
authors.lastname: Caron
mesh_terms: D000293:Adolescent; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D058345:Asymptomatic Infections; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005602:France; D006801:Humans; D007223:Infant; D008585:Meningitis, Meningococcal / Q000276:immunology / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D009345:Neisseria meningitidis / Q000276:immunology*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D022401:Meningococcal Vaccines
keywords: Carriage; Meningococci; Outbreak; Outer membrane vesicle vaccine