title: A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation.
abstract: Multifocal papillary thyroid carcinoma (mPTC) comprises about 20-30% of PTC. In mPTC, individual tumor foci can be identical or frequently composed of different histological types including follicular, solid, tall-cell or conventional patterns. We report a case of mPTC consisting of one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs in a 44-year-old woman. This case genetically demonstrates unique features including the simultaneous presence of the BRAF V600E (T1799A) mutation and the BRAF K601E (A1801G) mutation in conventional PTC and FVPTC, respectively.
authors.affiliation: Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Wook Youn
authors.initials: WY
authors.lastname: Kim
authors.forename: Young Sin
authors.initials: YS
authors.lastname: Ko
authors.forename: Tae Sook
authors.initials: TS
authors.lastname: Hwang
authors.forename: Hye Seung
authors.initials: HS
authors.lastname: Han
authors.forename: So Dug
authors.initials: SD
authors.lastname: Lim
authors.forename: Wan Seop
authors.initials: WS
authors.lastname: Kim
authors.forename: Seo Young
authors.initials: SY
authors.lastname: Oh
keywords: BRAF K601E; BRAF V600E; Carcinoma, papillary; Thyroid gland