title: ROS sets the stage for macrophage differentiation.
abstract: While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation and functions of M1 macrophages, is necessary for the differentiation of M2 macrophages and TAMs, and that antioxidant therapy blocks TAM differentiation and tumorigenesis in mouse models of cancer.
authors.affiliation: Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Covarrubias
authors.forename: Vanessa
authors.initials: V
authors.lastname: Byles
authors.forename: Tiffany
authors.initials: T
authors.lastname: Horng
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species