title: [The preliminary study of HBV genotype distribution and the relationship with clinical manifestation].
abstract: OBJECTIVE
  To explore the relationship between HBV genotypes distribution in hepatitis B patients and clinical manifestations in Beijing area.
  
  
  METHODS
  200 HBsAg positive serum were choosen from 1148 serum samples. useing of nested PCR amplification method, HBV DNA S genes were Sequencing and typing; genotype distribution and the relationship with the clinical manifestation were Statistical analysis.
  
  
  RESULTS
  In Beijing area, HBV has B, C, D three genotypes, including B gene type 17 cases (12. 5%), C genotype 116 cases (85.2%), D genotype 3 cases (0.02%); in the carriers, patients with chronic hepatitis B, cirrhosis, liver cancer, B type have been gradually falling, C type have been gradually rising trend.
  
  
  CONCLUSIONS
  Serious liver disease relate with C type, B type patients with HBV infection is better than C type patients in clinical prognosis and antivirus treatment response.
authors.affiliation: Luhe Hospital, Beijing 101149, China. 13720062144@163.com
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Jia
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Chang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000097:blood / Q000235:genetics*; D005260:Female; D005838:Genotype; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000821:virology*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000821:virology; D008113:Liver Neoplasms / Q000097:blood / Q000821:virology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D004279:DNA, Viral