title: Comparison of permethrin 2.5 % cream vs. Tenutex emulsion for the treatment of scabies.
abstract: Scabies is a common parasitic infestation that is an important public-health problem in many resource-poor regions. It is commonly treated with the insecticides but the treatment of choice is still controversial. This study aimed at comparing the efficacy of permethrin 2.5% cream vs. Tenutex emulsion for the treatment of scabies. In total, 440 patients with scabies were enrolled, and randomized into two groups The first group received permethrin 2.5% cream twice with one week interval and the second group received Tenutex emulsion and were told to apply this once whole-body application. Treatment was evaluated at intervals of 2 and 4 weeks, and if there was treatment failure at the 2-week follow-up, treatment was repeated.Two application of permethrin 2.5% cream provided a cure rate of 63.6% at the 2-week follow-up, which increased to 86.3% at the 4-week follow-up after repeating the treatment. Treatment with single applications of Tenutex emulsion was effective in 45.4% of patients at the 2-week follow-up, which increased to 59.1% at the 4-week follow-up after this treatment was repeated.Two application of permethrin 2.5% cream was as effective as single applications of Tenutex emulsion at the 2-week follow-up. After repeating the treatment, permethrin 2.5% cream was superior to Tenutex emulsion at the 4-week follow up.
authors.affiliation: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Drmgoldust@yahoo.com
authors.forename: Mohamad
authors.initials: M
authors.lastname: Goldust
authors.forename: Elham
authors.initials: E
authors.lastname: Rezaee
authors.forename: Ramin
authors.initials: R
authors.lastname: Raghifar
authors.forename: Mohammad
authors.initials: M
authors.lastname: Naghavi-Behzad
mesh_terms: D056810:Acaricides / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D026023:Permethrin / Q000627:therapeutic use*; D012532:Scabies / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D056810:Acaricides; D026023:Permethrin