title: The association between blood pressure and blood cadmium in a Chinese population living in cadmium polluted area.
abstract: Cadmium exposure may be associated with high risk of hypertension. But inconsistent results have been reported. In this study, the association of blood pressure (BP) with blood cadmium (BCd) and the possible influencing factors were investigated. A total of 181 persons (71 men and 110 women) living near a cadmium smelter participated in this study. The participants completed a questionnaire and BP, BCd and related biochemical indicators were measured. The geometric mean of BCd was 3.84μg/L and 3.32μg/L for women and men. The systolic blood pressure (SBP) and diastolic blood pressure both increased with the increasing of BCd. The BP in women was positively correlated with BCd (p<0.05). The BCd level of participants with hypertension was obvious higher (+28%) than those with normal BP. The prevalence of hypertension was increased with the increasing of BCd, in particular to women (χ(2)=3.896, p=0.048). Cadmium level in blood was associated with elevation in blood pressure, especially for women.
authors.affiliation: Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Institute of Radiation Medicine, Fudan University, Shanghai 200032, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Radiation Medicine, Fudan University, Shanghai 200032, China.
authors.forename: Guoying
authors.initials: G
authors.lastname: Zhu
authors.affiliation: School of Public Health, Fudan University, Shanghai 200032, China.
authors.forename: Lijian
authors.initials: L
authors.lastname: Lei
authors.affiliation: Institute of Radiation Medicine, Fudan University, Shanghai 200032, China. Electronic address: chx_win@hotmail.com.
authors.forename: Taiyi
authors.initials: T
authors.lastname: Jin
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D002104:Cadmium / Q000009:adverse effects* / Q000097:blood*; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D007220:Industrial Waste / Q000009:adverse effects*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012111:Residence Characteristics; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000097:blood*
chemical_list: D015415:Biomarkers; D007220:Industrial Waste; D014874:Water Pollutants, Chemical; D002104:Cadmium
keywords: Blood lipid; Blood pressure; Cadmium