title: [High-dose cyclophosphamide for severe aplastic anemia associated with β-thalassemia: a case report and literatures review].
abstract: OBJECTIVE
  To investigate the clinical features and therapeutic method for severe aplastic anemia (SAA) associated with β-thalassemia, and to improve the recognition of the disease.
  
  
  METHODS
  One patient hospitalized for pancytopenia was reported and the related literatures were reviewed.
  
  
  RESULTS
  A 14-years old girl who presented with anemia from her childhood was hospitalized for acute onset of pancytopenia. Routine blood test showed that WBC count was 1.28×10⁹/L, hemoglobin 65 g/L, platelet count 18×10⁹/L, reticulocyte count 2×10⁹/L, neutrophil count 0.03×10⁹/L and mean corpuscular volume 59.6 fl, respectively. Both bone marrow aspiration and biopsy showed hypoplasia. Her red blood cells presented as microcytic hypochromic and target erythrocytes were common on peripheral blood smear. DNA analysis of the patient and her mother showed exon 17 heterozygous β-thalassemia (c.52 A>T). A diagnosis of SAA associated with β-thalassemia was clarified and high-dose cyclophosphamide (HD-CTX, 1.2 g/d×4 d) plus cyclosporine were offeved, which eventually led to a complete hematologic remission 12 months later.
  
  
  CONCLUSIONS
  This was the first report of SAA associated with β-thalassemia, and the regimen of HD-CTX led to a complete hematologic remission.
authors.affiliation: Therapeutic Center of Anemia, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Kang
authors.initials: K
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Jing
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.forename: Guang-xin
authors.initials: GX
authors.lastname: Peng
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Li
authors.forename: Hui-hui
authors.initials: HH
authors.lastname: Fan
authors.forename: Lin
authors.initials: L
authors.lastname: Song
authors.forename: Feng-kui
authors.initials: FK
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D017086:beta-Thalassemia / Q000150:complications / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide