title: Bioaccessibility of polychlorinated biphenyls in workplace dust and its implication for risk assessment.
abstract: Human exposure to bioaccessible PCBs via indoor dust is limited around the world. In the present study, the workplace dust sample from commercial office, hospital, secondary school, shopping mall, electronic factory and manufacturing plant were collected from Hong Kong for PCBs analyses. Total PCBs concentrations ranged from 46.8 to 249 ng g(-1), with a median of 107 ng g(-1). Manufacturing plant showed the highest concentration among all of sampling sites. PCB 77 was found as the dominant congeners. The bioaccessibility of PCBs in small intestinal juice ranging from 8.3% to 26.0% was significantly higher than that in gastric condition, ranging from 4.8% to 12.4%. In addition, significant negative correlations (p<0.05) were observed between KOW and bioaccessibility for all workplace dust samples. Risk assessment indicated that the averaged daily dose of dioxin-like PCBs via non-dietary intake of workplace dust, considering the bioaccessibility of PCBs, were much lower than the TDI of dioxins (2.3 pg WHO-TEQ kgbw(-1)d(-1)) established by Joint FAO/WHO Expert Committee on Food Additives.
authors.affiliation: School of Chemistry & Environment, South China Normal University, Guangdong Technology Research Center for Ecological Management and Remediation of Urban Water System, Higher Education Mega Center, Guangzhou 510006, People's Republic of China; Croucher Institute for Environmental Sciences and Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. Electronic address: kangyuan407@gmail.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Kang
authors.forename: Yi
authors.initials: Y
authors.lastname: Yin
authors.forename: Yubon
authors.initials: Y
authors.lastname: Man
authors.forename: Laisheng
authors.initials: L
authors.lastname: Li
authors.forename: Qiuyun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lixuan
authors.initials: L
authors.lastname: Zeng
authors.forename: Jiwen
authors.initials: J
authors.lastname: Luo
authors.forename: Ming Hung
authors.initials: MH
authors.lastname: Wong
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis* / Q000706:statistics & numerical data; D004147:Dioxins / Q000032:analysis; D004391:Dust / Q000032:analysis*; D006723:Hong Kong; D006801:Humans; D016273:Occupational Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D011078:Polychlorinated Biphenyls / Q000032:analysis*; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis; D018570:Risk Assessment; D017132:Workplace / Q000706:statistics & numerical data*
chemical_list: D000395:Air Pollutants, Occupational; D004147:Dioxins; D004391:Dust; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls
keywords: Bioaccessibility; PCBs; Risk Assessment; Workplace dust