title: Update on anticytokine treatment for asthma.
abstract: Current advances in the knowledge of asthma pathobiology suggest that anticytokine therapies can be potentially useful for the treatment of this complex and heterogeneous airway disease. Recent evidence is accumulating in support of the efficacy of anti-IL-4, anti-IL-5, and anti-IL-13 drugs. Therefore, these new developments are now changing the global scenario of antiasthma therapies, especially with regard to more severe disease. Current findings referring to variability of individual therapeutic responses highlight that the different asthma subtypes need to be well characterized, in order to implement phenotype-targeted treatments which in the near future will hopefully be mainly based on cytokine-directed biologics.
authors.affiliation: Department of Health Science, University Magna Græcia of Catanzaro, Catanzaro, Italy. gallelli@unicz.it
authors.forename: Luca
authors.initials: L
authors.lastname: Gallelli
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Busceti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vatrella
authors.forename: Rosario
authors.initials: R
authors.lastname: Maselli
authors.forename: Girolamo
authors.initials: G
authors.lastname: Pelaia
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000473:pathology; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use*; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans
chemical_list: D001688:Biological Products; D016207:Cytokines