title: Can thyroid hormone mimics affect thyroid hormone measurement by immunoassay?
abstract: OBJECTIVE
  This study aims to determine whether the environmental pollutant and thyroid mimic, tetrabromobisphenol A (TBBPA), interferes with thyroid hormone measurement by immunoassays.
  
  
  METHODS
  Hormone-relevant concentrations of TBBPA were added to thyroid hormone-stripped human serum and subjected to 6 different thyroid hormone immunoassays.
  
  
  RESULTS
  TBBPA was negative in all of the thyroid hormone immunoassays tested except at very high concentration (above that expected in serum of TBBPA-exposed workers) where it gave a marginally positive result in one immunoassay (in house T4 radioimmunoassay (RIA)).
  
  
  CONCLUSIONS
  Serum TBBPA present as a result of workplace exposure or its use as a fabric flame retardant is very unlikely to give false positive results in thyroid hormone immunoassays.
authors.affiliation: Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
authors.forename: C R
authors.initials: CR
authors.lastname: McIver
authors.forename: I C
authors.initials: IC
authors.lastname: Shaw
authors.forename: S
authors.initials: S
authors.lastname: Gin
authors.forename: M J
authors.initials: MJ
authors.lastname: Ellis
mesh_terms: D004785:Environmental Pollutants / Q000097:blood*; D005189:False Positive Reactions; D006801:Humans; D007118:Immunoassay / Q000379:methods / Q000592:standards*; D011075:Polybrominated Biphenyls / Q000097:blood*; D013961:Thyroid Gland / Q000473:pathology; D013963:Thyroid Hormones / Q000097:blood* / Q000302:isolation & purification
chemical_list: D004785:Environmental Pollutants; D011075:Polybrominated Biphenyls; D013963:Thyroid Hormones; C020806:tetrabromobisphenol A
keywords: Hormone mimics; Immunoassay; T4; Tetrabromobisphenol A (TBBPA); Thyroid hormones