title: Electrochemical sensor for selective determination of N-acetylcysteine in the presence of folic acid using a modified carbon nanotube paste electrode.
abstract: In the present paper, a novel benzoylferrocene (BF) modified carbon nanotube paste electrode (BFCNPE) was prepared. The modified electrode was further used for the successful determination of N-acetylcysteine (NAC), and it showed an excellent electrocatalytic oxidation activity toward NAC with a lower overvoltage, pronounced current response, and good sensitivity. Under the optimized experimental conditions, the proposed electrochemical NAC sensor exhibited a linear calibration plot that ranged from 3.0×10(-7) to 7.0×10(-4) M with a detection limit of 9.0×10(-8) M. Also, Square wave voltammetry (SWV) was used for simultaneous determination of NAC and folic acid (FA) at the modified electrode. Finally, the proposed method was applied to the determination of NAC in NAC tablets.
authors.affiliation: Environment Department, International Center for Science, High Technology & Environmental Sciences, Kerman, Iran. h.beitollahi@yahoo.com
authors.forename: Hadi
authors.initials: H
authors.lastname: Beitollahi
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Taher
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mirrahimi
authors.forename: Rahman
authors.initials: R
authors.lastname: Hosseinzadeh
mesh_terms: D000111:Acetylcysteine / Q000032:analysis*; D002138:Calibration; D002384:Catalysis; D004560:Electricity; D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D005296:Ferrous Compounds / Q000737:chemistry; D005492:Folic Acid / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D000075163:Metallocenes; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D013607:Tablets
chemical_list: D005296:Ferrous Compounds; D000075163:Metallocenes; D037742:Nanotubes, Carbon; D013607:Tablets; D005492:Folic Acid; C004998:ferrocene; D000111:Acetylcysteine
keywords: Carbon nanotubes; Carbon paste electrode; Electrocatalysis; Folic acid; N-acetylcysteine