title: Efficacy of ketoprofen administered in drinking water at a low dose for the treatment of porcine respiratory disease complex.
abstract: The purpose of this study was to evaluate the efficacy of an oral solution of ketoprofen administered in drinking water at a lower dose as a complement to antimicrobial therapy in a mild outbreak of porcine respiratory disease complex. The study was performed with 120 pigs with rectal temperature between 39.9 and 41°C and at least 1 sign indicating porcine respiratory disease complex (dyspnea, cough, nasal discharge, or depression). Animals were randomly allocated in 2 groups (treated and control group). Animals in both groups received etiological therapy with doxycycline at 10 mg · kg(-1) in drinking water for 5 d. The animals in the treated group also received 1.5 mg · kg(-1) of ketoprofen during the first 3 d. The reduction in rectal temperature in the treated group was significantly greater during the days of ketoprofen administration and up to 1 d after the end of treatment (P < 0.05). The percentage of dyspneic animals was significantly less (P < 0.05) in the treated group from d 2 to 5 of the study. Also, a significant improvement regarding depression and cough was seen in the animals of the treated group. No statistically significant (P > 0.05) differences were evidenced in productive variables. In conclusion, oral treatment with ketoprofen at 1.5 mg · kg(-1) in combination with antimicrobial therapy was found to be a clinically effective approach in outbreaks of mild porcine respiratory disease complex.
authors.affiliation: Department of Research and Development, ESTEVE veterinaria, Laboratorios Dr. ESTEVE S.A., Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Salichs
authors.forename: D
authors.initials: D
authors.lastname: Sabaté
authors.forename: J
authors.initials: J
authors.lastname: Homedes
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use; D060766:Drinking Water; D004359:Drug Therapy, Combination / Q000662:veterinary; D005260:Female; D007660:Ketoprofen / Q000627:therapeutic use*; D008297:Male; D019318:Porcine Reproductive and Respiratory Syndrome / Q000188:drug therapy* / Q000821:virology; D013552:Swine; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D060766:Drinking Water; D007660:Ketoprofen; D004318:Doxycycline