title: Protective effect of the KIR2DS1 gene in atopic dermatitis.
abstract: Atopic dermatitis (AD) is a common skin disease of complex etiology including affected humoral and cellular immune responses. The role of NK cells in development of this disease has been recently postulated, but is still poorly documented. The current study was undertaken to determine the impact of genes for the most polymorphic NK cell receptors, known as killer cell immunoglobulin-like receptors (KIRs), on the development of AD. We compared 240 patients suffering from AD with 570 healthy controls. Frequencies of the great majority of KIR genes did not differ between patients and controls, except for KIR2DS1, whose frequency was significantly (OR=0.629, CI95% (0.45; 0.87), pcorr=0.0454) lower in patients than in controls. These results were confirmed in a second cohort of 201 patients. When both patient groups were combined and compared to the control group, the result for KIR2DS1 achieved even higher significance (OR=0.658, CI95% (0.5; 0.86), pcorr=0.0158). To the best of our knowledge, this is the first report on KIR gene contribution to AD, and to allergy in general.
authors.affiliation: Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, 53-114 Wrocław, Poland.
authors.forename: Wanda
authors.initials: W
authors.lastname: Niepiekło-Miniewska
authors.forename: Edyta
authors.initials: E
authors.lastname: Majorczyk
authors.forename: Lukasz
authors.initials: L
authors.lastname: Matusiak
authors.forename: Ketevan
authors.initials: K
authors.lastname: Gendzekhadze
authors.forename: Izabela
authors.initials: I
authors.lastname: Nowak
authors.forename: Joanna
authors.initials: J
authors.lastname: Narbutt
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lesiak
authors.forename: Piotr
authors.initials: P
authors.lastname: Kuna
authors.forename: Joanna
authors.initials: J
authors.lastname: Ponińska
authors.forename: Aneta
authors.initials: A
authors.lastname: Pietkiewicz-Sworowska
authors.forename: Bolesław
authors.initials: B
authors.lastname: Samoliński
authors.forename: Rafał
authors.initials: R
authors.lastname: Płoski
authors.forename: Jacek C
authors.initials: JC
authors.lastname: Szepietowski
authors.forename: David
authors.initials: D
authors.lastname: Senitzer
authors.forename: Piotr
authors.initials: P
authors.lastname: Kuśnierczyk
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000517:prevention & control; D000939:Epitopes / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D054340:Receptors, KIR / Q000235:genetics*; D055815:Young Adult
chemical_list: D000939:Epitopes; D006680:HLA Antigens; C496212:KIR2DS1 protein, human; D054340:Receptors, KIR
keywords: 95% confidence intervals; AD; Atopic dermatitis; CD; CI95%; DNA; Genetics; HLA; HLA-C; KIR; Killer cell immunoglobulin-like receptor; LD; OR; PCR-SSP; SCORAD; UV; atopic dermatitis; cluster of differentiation; corrected p; deoxyribonucleic acid; human leukocyte antigen; killer cell immunoglobulin-like receptor; linkage disequilibrium; odds ratio; p; p(corr); polymerase chain reaction using sequence-specific primers; probability; scoring atopic dermatitis, index of disease severity; ultraviolet