title: Nitrite in organ protection.
abstract: In the last decade, the nitrate-nitrite-nitric oxide pathway has emerged to therapeutical importance. Modulation of endogenous nitrate and nitrite levels with the subsequent S-nitros(yl)ation of the downstream signalling cascade open the way for novel cytoprotective strategies. In the following, we summarize the actual literature and give a short overview on the potential of nitrite in organ protection.
authors.affiliation: Department of Medicine, Division of Cardiology, Pulmonary and Vascular Medicine, University Hospital Düsseldorf, Düsseldorf, Germany.
authors.forename: Tienush
authors.initials: T
authors.lastname: Rassaf
authors.forename: Peter
authors.initials: P
authors.lastname: Ferdinandy
authors.forename: Rainer
authors.initials: R
authors.lastname: Schulz
mesh_terms: D000818:Animals; D019610:Cytoprotection; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D015427:Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D009566:Nitrates; D009573:Nitrites; D020011:Protective Agents; D009569:Nitric Oxide
keywords: nitric oxide; nitrite