title: Impaired virulence and fitness of a colistin-resistant clinical isolate of Acinetobacter baumannii in a rat model of pneumonia.
abstract: We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronounced signs of infection (lung bacterial count, systemic dissemination, and lung damage) and a better outcome (ABCR and ABCS mortality rates, 20 and 50%, respectively [P = 0.03]).
authors.affiliation: Aix-Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
authors.forename: Sami
authors.initials: S
authors.lastname: Hraiech
authors.forename: Antoine
authors.initials: A
authors.lastname: Roch
authors.forename: Hubert
authors.initials: H
authors.lastname: Lepidi
authors.forename: Thérèse
authors.initials: T
authors.lastname: Atieh
authors.forename: Gilles
authors.initials: G
authors.lastname: Audoly
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Rolain
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Brunel
authors.forename: Laurent
authors.initials: L
authors.lastname: Papazian
authors.forename: Fabienne
authors.initials: F
authors.lastname: Brégeon
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000472:pathogenicity*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D051381:Rats; D014774:Virulence
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin