title: Stochastic analysis of epidemics on adaptive time varying networks.
abstract: Many studies investigating the effect of human social connectivity structures (networks) and human behavioral adaptations on the spread of infectious diseases have assumed either a static connectivity structure or a network which adapts itself in response to the epidemic (adaptive networks). However, human social connections are inherently dynamic or time varying. Furthermore, the spread of many infectious diseases occur on a time scale comparable to the time scale of the evolving network structure. Here we aim to quantify the effect of human behavioral adaptations on the spread of asymptomatic infectious diseases on time varying networks. We perform a full stochastic analysis using a continuous time Markov chain approach for calculating the outbreak probability, mean epidemic duration, epidemic reemergence probability, etc. Additionally, we use mean-field theory for calculating epidemic thresholds. Theoretical predictions are verified using extensive simulations. Our studies have uncovered the existence of an "adaptive threshold," i.e., when the ratio of susceptibility (or infectivity) rate to recovery rate is below the threshold value, adaptive behavior can prevent the epidemic. However, if it is above the threshold, no amount of behavioral adaptations can prevent the epidemic. Our analyses suggest that the interaction patterns of the infected population play a major role in sustaining the epidemic. Our results have implications on epidemic containment policies, as awareness campaigns and human behavioral responses can be effective only if the interaction levels of the infected populace are kept in check.
authors.affiliation: Indian Institute of Science, Department of Electronic Systems Engineering, Bangalore 560012, India. bkotnis@dese.iisc.ernet.in
authors.forename: Bhushan
authors.initials: B
authors.lastname: Kotnis
authors.forename: Joy
authors.initials: J
authors.lastname: Kuri
mesh_terms: D003141:Communicable Diseases / Q000196:embryology*; D003198:Computer Simulation; D016358:Contact Tracing / Q000379:methods*; D003627:Data Interpretation, Statistical; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D018562:Disease Transmission, Infectious / Q000706:statistics & numerical data*; D006801:Humans; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D013269:Stochastic Processes