title: Restrictive pulmonary deficit is associated with inflammation in sub-optimally controlled obese diabetics.
abstract: Caribbean data linking inflammation, pulmonary dysfunction and diabetes is unavailable. Spirometry, acanthosis nigricans, hs-CRP were assessed in 109 type 2 diabetics (43% males) mean age=55.6 years, BMI=29.29 kg/m(2), waist circumference=103.86 cm. Residual FEV1/FVC increased with age (P=0.005), BMI (P=0.011) and waist circumference (P=0.003). Residual FVC related inversely to hs-CRP (-0.178), P<0.06) systolic (-0.028, P<0.031), diastolic (-0.247, P<0.010) pressure and weight (-0.25, P<0.009). Residual FEV1 related inversely to diastolic pressure (-0.219, P<0.023), hs-CRP (-0.234, P<0.015), acanthosis nigricans (-0.029, P<0.029). HbA1C and residual FEV1 predict high hs-CRP (P=0.011, P=0.046). Low FVC with inflammation presents in poorly controlled obese diabetics.
authors.affiliation: Departments of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago, West Indies.
authors.forename: Lexley M
authors.initials: LM
authors.lastname: Pinto Pereira
authors.forename: Terence A R
authors.initials: TA
authors.lastname: Seemungal
authors.forename: Surujpal
authors.initials: S
authors.lastname: Teelucksingh
authors.forename: B Shivananda
authors.initials: BS
authors.lastname: Nayak
keywords: Impaired pulmonary function; diabetes mellitus type 2; obesity; systemic inflammation