title: [The function of osteopontin and other cytokines in the diagnosis of Sjoigren's syndrome].
abstract: OBJECTIVE
  To explore the relationship of serum concentrations of osteopontin(OPN), TNF-α and TGF-β1 in Sjoigren's syndrome patients.
  
  
  METHODS
  Forty Sjoigren's syndrome (SS) patients were determined by pathological examination, which included 15 primary SS and 25 secondary SS. Serum level of OPN, TNF-alpha and TGF-beta 1 were examined by enzyme linked immunosorbent assay (ELISA). Multiple correlation analysis was performed using SPSS13.0 software package.
  
  
  RESULTS
  Serum OPN, TNF-alpha levels increased in SS compared with healthy subjects (P<0.05).Serum TGF-beta 1 level in secondary SS significantly increased than primary SS (P<0.05). On the contrary, serum TGF-beta1 level had no significant change compared with the controls. OPN was correlated with TGF-beta 1.
  
  
  CONCLUSIONS
  OPN and TNF-alpha may be used as adjunctive diagnostic parameter. TGF-beta 1 can be used as an index in differential diagnosis of primary and secondary SS. OPN and TGF-beta 1 have different effects and interactions between them, demonstrating mutuality, diversity and integrity of the cytokine network.
authors.affiliation: Department of Oral Mucosal Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. dentist1609@hotmail.com
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Ben-juan
authors.initials: BJ
authors.lastname: Wei
authors.forename: Hai-wen
authors.initials: HW
authors.lastname: Zhou
mesh_terms: D016207:Cytokines; D006801:Humans; D053495:Osteopontin; D012859:Sjogren's Syndrome; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha
chemical_list: D016207:Cytokines; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D053495:Osteopontin