title: KPC-producing, multidrug-resistant Klebsiella pneumoniae sequence type 258 as a typical opportunistic pathogen.
abstract: The virulence of a KPC-producing Klebsiella pneumoniae sequence type 258 (ST258) strain representing those circulating in Greece was assessed in a mouse septicemia model. The strain was virtually avirulent (50% lethal dose, >10(8) and 5 × 10(7) CFU for immunocompetent and neutropenic animals, respectively). Also, it was highly susceptible to serum killing, rapidly phagocytosed in vitro, and classified as K41, which is not among the virulent capsular types. The findings indirectly support the notion that high ST258-associated mortality is largely due to inefficient antimicrobial treatment.
authors.affiliation: Department of Microbiology, Medical School, University of Athens.
authors.forename: L S
authors.initials: LS
authors.lastname: Tzouvelekis
authors.forename: V
authors.initials: V
authors.lastname: Miriagou
authors.forename: S D
authors.initials: SD
authors.lastname: Kotsakis
authors.forename: K
authors.initials: K
authors.lastname: Spyridopoulou
authors.forename: E
authors.initials: E
authors.lastname: Athanasiou
authors.forename: E
authors.initials: E
authors.lastname: Karagouni
authors.forename: E
authors.initials: E
authors.lastname: Tzelepi
authors.forename: G L
authors.initials: GL
authors.lastname: Daikos
mesh_terms: D000818:Animals; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology*; D051379:Mice; D008813:Mice, Inbred ICR; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases