title: Sex-different effects of tributyltin on brain aromatase, estrogen receptor and retinoid X receptor gene expression in rockfish (Sebastiscus marmoratus).
abstract: Since the brain plays important roles in reproduction, the brain aromatase (Cyp19b), estrogen receptor (ER), retinoid X receptor (RXR) α and peroxisome proliferator-activated receptor γ were examined in rockfish after TBT exposure (1, 10, and 100 ng L(-1)). The results showed that the Cyp19b expression was elevated in the male rockfish, while no effect was produced in the females. Inconsistently, serum testosterone and 17β-estradiol showed no change in the males, while an increase of testosterone and a decrease of 17β-estradiol were observed in the females. TBT affected the ER expression in the males depending on the concentrations, however, no change was observed in the females. In addition, TBT elevated the RXRα expression in the males but produced an opposite effect in the females. In conclusion, TBT might have had sex-different effects on the brain Cyp19b, ER and RXR expression in rockfish, indicating a complex endocrine disrupting effect of TBT.
authors.affiliation: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, PR China.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Zuo
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhu
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.forename: Chonggang
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D001141:Aromatase / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002681:China; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D005399:Fishes / Q000235:genetics / Q000502:physiology*; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D008297:Male; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics* / Q000378:metabolism; D012727:Sex Characteristics; D013997:Time Factors; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D012739:Gonadal Steroid Hormones; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D014220:Trialkyltin Compounds; D014874:Water Pollutants, Chemical; C011559:tributyltin; D001141:Aromatase
keywords: Brain; Effects-fish; Environmental toxicology; Estrogen receptor; Organotins; Retinoid X receptor α; Sebastiscus marmoratus