title: Ruthenium catalyzed reductive coupling of paraformaldehyde to trifluoromethyl allenes: CF3-bearing all-carbon quaternary centers.
abstract: Trifluoromethyl substituted allenes engage in ruthenium catalyzed reductive couplings with paraformaldehyde to form products of hydrohydroxymethylation as single regioisomers. This method enables generation of CF3-bearing all-carbon quaternary stereocenters.
authors.affiliation: University of Texas at Austin, Department of Chemistry and Biochemistry, Austin, Texas 78712, USA.
authors.forename: Brannon
authors.initials: B
authors.lastname: Sam
authors.forename: T Patrick
authors.initials: TP
authors.lastname: Montgomery
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D005557:Formaldehyde / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000466:Alkadienes; D006845:Hydrocarbons, Fluorinated; D011108:Polymers; D005557:Formaldehyde; D012428:Ruthenium; C003043:paraform