title: An engineered plant peroxisome and its application in biotechnology.
abstract: Plant metabolic engineering is a promising tool for biotechnological applications. Major goals include enhancing plant fitness for an increased product yield and improving or introducing novel pathways to synthesize industrially relevant products. Plant peroxisomes are favorable targets for metabolic engineering, because they are involved in diverse functions, including primary and secondary metabolism, development, abiotic stress response, and pathogen defense. This review discusses targets for manipulating endogenous peroxisomal pathways, such as fatty acid β-oxidation, or introducing novel pathways, such as the synthesis of biodegradable polymers. Furthermore, strategies to bypass peroxisomal pathways for improved energy efficiency and detoxification of environmental pollutants are discussed. In sum, we highlight the biotechnological potential of plant peroxisomes and indicate future perspectives to exploit peroxisomes as biofactories.
authors.affiliation: Heinrich-Heine University, Plant Biochemistry, Universitätsstrasse 1, Building 26.03.01, D-40225 Düsseldorf, Germany. Sarah.Vigelius@hhu.de
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Kessel-Vigelius
authors.forename: Jan
authors.initials: J
authors.lastname: Wiese
authors.forename: Martin G
authors.initials: MG
authors.lastname: Schroers
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Wrobel
authors.forename: Florian
authors.initials: F
authors.lastname: Hahn
authors.forename: Nicole
authors.initials: N
authors.lastname: Linka
mesh_terms: D018533:Biomass; D001709:Biotechnology; D053858:Metabolic Networks and Pathways; D020675:Peroxisomes / Q000235:genetics / Q000378:metabolism*; D057865:Plant Immunity; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D030821:Plants, Genetically Modified; D017382:Reactive Oxygen Species / Q000378:metabolism; D013312:Stress, Physiological
chemical_list: D010940:Plant Proteins; D017382:Reactive Oxygen Species
keywords: Biotechnology; Genetic engineering; H(2)O(2); JA; Metabolism; PHA; Peroxisome; ROS; Stress tolerance; hydrogen peroxide; jasmonic acid; polyhydroxyalkanoate; reactive oxygen species