title: Evaluation of tissue response to Gore-Tex (expanded polytetrafluoroethylene) implantation.
abstract: OBJECTIVE
  The aim of this study was to assess the tissue response to Gore-Tex (expanded polytetrafluoroethylene) in rats and compare the results of surgical placement modalities.
  
  
  METHODS
  Prospective animal study.
  
  
  METHODS
  Experiments were performed in 18 young Sprague-Dawley rats that were divided into 3 groups. Gore-Tex patches were implanted subcutaneously over the periosteum in the first group and under the periosteum in the other groups. Gore-Tex was immersed in an antibiotic-containing solution in the third group. All animals were killed 4 weeks after the procedure. The tissue samples were stained with hematoxylin and eosin stain and evaluated using a light microscope.
  
  
  RESULTS
  The Gore-Tex patches were displaced and not observed at the originally implanted sites in the first group. The Gore-Tex patches were observed at the originally implanted sites in the other groups. In group 1, edema and inflammation were prominent. In the second group, ossification was detected in 5 rats and foreign-body reaction and edema were identified in 1 rat. In the third group, all of the rats were found to have developed ossification, but no inflammatory reactions were observed.
  
  
  CONCLUSIONS
  The results suggest that implanting synthetic graft materials immersed in an antibiotic solution at the subperiosteal plane provides better stabilization and low complication rates.
authors.affiliation: Department of Otorhinolaryngology, Acibadem University School of Medicine, Marmara University School of Medicine, Pendik, Istanbul, Turkey.
authors.forename: Gediz
authors.initials: G
authors.lastname: Serin
authors.forename: Serdar
authors.initials: S
authors.lastname: Baylancicek
authors.forename: Elif
authors.initials: E
authors.lastname: Aksoy
authors.forename: Senol
authors.initials: S
authors.lastname: Polat
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Sağlican
authors.forename: Selcuk
authors.initials: S
authors.lastname: Inanli
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004487:Edema / Q000209:etiology; D005548:Foreign-Body Migration / Q000209:etiology; D005549:Foreign-Body Reaction / Q000209:etiology; D006097:Granulation Tissue / Q000473:pathology; D007249:Inflammation; D010012:Osteogenesis / Q000502:physiology; D010521:Periosteum / Q000601:surgery; D011138:Polytetrafluoroethylene / Q000737:chemistry*; D019919:Prosthesis Implantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012294:Rifamycins / Q000737:chemistry; D040521:Subcutaneous Tissue / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D012294:Rifamycins; D011138:Polytetrafluoroethylene