title: Human serum albumin mutants complexed Mn(III) protoporphyrin IX as superoxide dismutase mimics.
abstract: Genetically engineered human serum albumin (HSA) mutants complexed Mn(III) protoporphyrin IX (MnPP) in the haem pocket showed superoxide dismutase activity. Replacement of a proximal Tyr-161 by non-coordinating Leu caused a remarkable increase in enzyme activity.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. komatsu@kc.chuo-u.ac.jp.
authors.forename: Ryunosuke
authors.initials: R
authors.lastname: Kato
authors.forename: Yuya
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Motofusa
authors.initials: M
authors.lastname: Akiyama
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Komatsu
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D006801:Humans; D008345:Manganese / Q000737:chemistry*; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D017354:Point Mutation; D011524:Protoporphyrins / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D056831:Coordination Complexes; D011524:Protoporphyrins; D012709:Serum Albumin; D008345:Manganese; C028025:protoporphyrin IX; D013482:Superoxide Dismutase