title: In vitro measurements of physiological glucose concentrations in biological fluids using mid-infrared light.
abstract: Mid-infrared transmission spectroscopy using broadband mid-infrared or Quantum Cascade laser sources is used to predict glucose concentrations of aqueous and serum solutions containing physiologically relevant amounts of glucose (50-400 mg/dL). We employ partial least squares regression to generate a calibration model using a subset of the spectra taken and to predict concentrations from new spectra. Clinically accurate measurements with respect to a Clarke error grid were made for concentrations as low as 30 mg/dL, regardless of background solvent. These results are an important and encouraging step in the work towards developing a noninvasive in vivo glucose sensor in the mid-infrared.
authors.affiliation: Department of Electrical Engineering, Princeton University, Princeton, NJ 08540, USA.
authors.forename: Sabbir
authors.initials: S
authors.lastname: Liakat
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Bors
authors.forename: Tzu-Yung
authors.initials: TY
authors.lastname: Huang
authors.forename: Anna P M
authors.initials: AP
authors.lastname: Michel
authors.forename: Eric
authors.initials: E
authors.lastname: Zanghi
authors.forename: Claire F
authors.initials: CF
authors.lastname: Gmachl
keywords: (170.1470) Blood or tissue constituent monitoring; (300.1030) Absorption; (300.6340) Spectroscopy, infrared