title: Effectiveness of aspirin on double lumen permanent catheter efficacy in ESRD.
abstract: BACKGROUND
  The complications of vascular access are the most imperative etiology for hospitalization, morbidity and mortality in chronic hemodialysis. The most prevalent complication of central catheter is dysfunction due to thrombosis. Aspirin is an anti-aggregative platelet drug that may increase the patency of permanent catheters (perm-cath).
  
  
  OBJECTIVE
  The aim of this study was to evaluate the role of Aspirin in perm-cath survival.
  
  
  METHODS
  This study included a total of 185 ESRD cases according to the inclusion criteria for perm-cath insertion in hemodialysis. One hundred and eighty patients following perm-cath insertion had proper blood flow through perm-cath during hemodialysis. Patients were randomly divided between intervention (80 mg/day Aspirin initiated a day following catheter insertion) and control (placebo) groups. The average time that the perm-cath was functional was noted. Demographic characteristics included comorbidities and past history were also used to address probable influence on perm-cath function and patency.
  
  
  RESULTS
  The mean survival time of the catheter in Aspirin group was significantly higher than the control group (5.3 ± 4.7 month versus 3.9 ± 2.7 month, P = 0.012). No significant difference in major complications of Aspirin use (such as GI bleeding) was noted between two groups (P = 0.52). In terms of the patient's demographic characteristics, those of the female gender and a history of diabetes mellitus were found to have significant influence on median survival rate of the catheters (P = 0.021, 0.043 respectively).
  
  
  CONCLUSIONS
  These results suggest that Aspirin use following perm-cath insertion might be beneficial for catheter survival. This increased survival time might enable patient's use of AVF maturation for long term dialysis access.
authors.affiliation: Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mozafar
authors.forename: Majid
authors.initials: M
authors.lastname: Samsami
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Sobhiyeh
authors.forename: Sayena
authors.initials: S
authors.lastname: Jabbehdari
authors.forename: Mahtab
authors.initials: M
authors.lastname: Fallah Zavareh
keywords: Aspirin; Catheters; Kidney Failure, Chronic Effects