title: [Protective effect of anti-hypoxia shenggui tablet on cerebral ischemia injure].
abstract: OBJECTIVE
  To investigate the protective effects of Shengui tablet (Chinese Traditional Medicine) on experimental cerebral ischemia by acute cerebral ischemia hypoxia in mice and bilateral ligation of the carotid artery in rats.
  
  
  METHODS
  In the acute cerebral ischemia hypoxia model, the mice were randomly divided into control group, low-, middle- and high-dose (0.16, 0.33 and 1.00 g/kg) groups of Shengui tablet, after oral treatment for 30 d, gasping time of isolated heads of mice were observed. In bilateral ligation of the carotid artery cerebral ischemia model, the rats were randomly divided into control group, model group and low-, middle-, high-dose (0.072, 0.149 and 0.450 g/kg) groups of Shengui tablet. After oral treatment for 7 d, the cerebral index, superoxide dismutase (SOD) activity and the content of malondialdehyde (MDA) were measured.
  
  
  RESULTS
  Compared with the control model, Shengui tablet middle- and high-dose could significantly prolong gasping time of isolate heads of mice. Compared with model group, Shengui tablet low-, middle- and high-dose could significantly decrease the cerebral index and enhance SOD activity in brain tissue; only high-dose could reduce the content of MDA.
  
  
  CONCLUSIONS
  Shengui tablet has significant protective effect on the cerebral ischemia.
authors.affiliation: Thadweik Academy of Medicine, Beijing 100039, China.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Huai-Xin
authors.initials: HX
authors.lastname: Wang
authors.forename: Jin-Da
authors.initials: JD
authors.lastname: Wang
authors.forename: Ru-Huan
authors.initials: RH
authors.lastname: Wang
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Zhang
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Cui
authors.forename: Lian
authors.initials: L
authors.lastname: Duan
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism* / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D018696:Neuroprotective Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D008315:Malondialdehyde; D013482:Superoxide Dismutase