title: Early T-cell precursor leukemia/lymphoma in adults and children.
abstract: Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR=4.08, p=0.127, and children, HR=11.63, p=0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL.
authors.affiliation: Department of Pathology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
authors.forename: Ashleigh
authors.initials: A
authors.lastname: Allen
authors.forename: Anthony
authors.initials: A
authors.lastname: Sireci
authors.forename: Adrianna
authors.initials: A
authors.lastname: Colovai
authors.forename: Kerice
authors.initials: K
authors.lastname: Pinkney
authors.forename: Maria
authors.initials: M
authors.lastname: Sulis
authors.forename: Govind
authors.initials: G
authors.lastname: Bhagat
authors.forename: Bachir
authors.initials: B
authors.lastname: Alobeid
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D020732:Cytogenetic Analysis; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D011379:Prognosis; D012074:Remission Induction; D015996:Survival Rate; D055815:Young Adult
keywords: ALL; Acute leukemia; Adults; Children; Early T-cell precursors; Leukemia; Lymphoblastic; Lymphoma; Prognosis