title: An efficient synthesis of the fully elaborated isoindolinone unit of muironolide A.
abstract: An efficient stereocontrolled construction of the fully substituted isoindolone subunit of muironolide A is described. The approach is centered on the intramolecular Diels-Alder reaction between the enol form of the β-keto amide and an α,β,γ,δ-unsaturated ester, followed by the installation of the cyclohexene double bond.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xiao
authors.forename: Kyle
authors.initials: K
authors.lastname: Young
authors.forename: Armen
authors.initials: A
authors.lastname: Zakarian
mesh_terms: D002384:Catalysis; D003500:Cyclization; D053138:Cyclohexenes / Q000737:chemistry*; D004952:Esters; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D053138:Cyclohexenes; D004952:Esters; C110621:Isoindol-1-one; D054833:Isoindoles; C568569:muironolide A