title: Tumor fibroblast specific activation of a hybrid ferritin nanocage-based optical probe for tumor microenvironment imaging.
abstract: Ferritin-based FAP-α-responsive fluorescence nanoprobes could be activated immediately as they penetrate the tumor blood vessels and come across the FAP-α molecules on the membrane of CAFs in the tumor microenvironment instead of reaching a certain depth into tumor tissue to interact with tumor cells. This probe may become a promising nanomaterial for highly specific and sensitive tumor imaging through responding to the enzymes in the tumor microenvironment.
authors.affiliation: Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Ji
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Zheng
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Tian
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Guangjun
authors.initials: G
authors.lastname: Nie
mesh_terms: D045744:Cell Line, Tumor; D005293:Ferritins / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D009369:Neoplasms / Q000473:pathology*; D059016:Tumor Microenvironment
chemical_list: D005293:Ferritins
keywords: cancer-associated fibroblasts; ferritin; fibroblast activation protein-α; imaging; nanotechnology