title: Protection of montelukast on OVA-induced eosinophilic gastroenteritis via modulating IL-5, eotaxin-1 and MBP expression.
abstract: The aim of this study was to further explore the possible mechanisms of montelukast on oral mice ovalbumin-induced eosinophilic gastroenteritis in a mouse model. The results indicated that montelukast could prevent levels of eotaxin-1 and interleukin-5 in intestinal mucosa homogenate when compared with model group. Interestingly, the increase of major basic protein expression in jejunal tissue also was attenuated by treated with montelukast.
authors.affiliation: Provincial Hospital Affiliated to Shandong University , Jinan 250014 , PR China and.
authors.forename: Daihong
authors.initials: D
authors.lastname: Wan
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuemei
authors.initials: X
authors.lastname: Liu
authors.forename: Guimei
authors.initials: G
authors.lastname: Li
mesh_terms: D000085:Acetates / Q000494:pharmacology; D000818:Animals; D054413:Chemokine CCL11 / Q000276:immunology*; D003521:Cyclopropanes; D004751:Enteritis / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology*; D047093:Eosinophil Major Basic Protein / Q000276:immunology*; D004802:Eosinophilia / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology*; D005756:Gastritis / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology*; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000276:immunology; D015848:Interleukin-5 / Q000276:immunology*; D020024:Leukotriene Antagonists / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000633:toxicity*; D011804:Quinolines / Q000494:pharmacology; D013440:Sulfides
chemical_list: D000085:Acetates; C515457:Ccl11 protein, mouse; D054413:Chemokine CCL11; D003521:Cyclopropanes; D015848:Interleukin-5; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; D010047:Ovalbumin; D047093:Eosinophil Major Basic Protein; C093875:montelukast