title: Salivary alpha-amylase as a biomarker for the osmopressor response in healthy adults.
abstract: Water ingestion induces a sympathetically mediated increase in blood pressure in dysautonomic patients and the elderly, but not consistently in young healthy subjects. The aim of study was to determine the extent of the pressor response and changes of sympathetic activity biomarker salivary alpha-amylase (sAA) after water ingestion in young healthy subjects. Compared with ingestion of 50 mL of water, the blood pressure, total peripheral resistance and sAA significantly increased and the plasma osmolality decreased 25 min after drinking 500 mL of water. The results confirm the osmopressor response in young subjects and suggest that sAA may be used as a non-invasive marker of sympathetic activity in future studies.
authors.affiliation: Institute of Aerospace and Undersea Medicine, School of Medicine, National Defense Medical Center , Taipei , Taiwan .
authors.forename: Hsin
authors.initials: H
authors.lastname: Chu
authors.forename: You-Hsiang
authors.initials: YH
authors.lastname: Chu
authors.forename: Herng-Sheng
authors.initials: HS
authors.lastname: Lee
authors.forename: Shung-Tai
authors.initials: ST
authors.lastname: Ho
authors.forename: Che-Se
authors.initials: CS
authors.lastname: Tung
authors.forename: Ching-Jiunn
authors.initials: CJ
authors.lastname: Tseng
authors.forename: Chih-Cherng
authors.initials: CC
authors.lastname: Lu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D001794:Blood Pressure; D060766:Drinking Water; D006801:Humans; D064587:Osmoregulation; D012016:Reference Values; D012463:Saliva / Q000201:enzymology*; D000516:alpha-Amylases / Q000032:analysis*
chemical_list: D015415:Biomarkers; D060766:Drinking Water; D000516:alpha-Amylases