title: An integrated open-cavity system for magnetic bead manipulation.
abstract: Superparamagnetic beads are increasingly used in biomedical assays to manipulate, transport, and maneuver biomaterials. We present a low-cost integrated system designed in bulk CMOS to manipulate and separate biomedical magnetic beads. The system consists of 8 × 8 coil-arrays suitable for single bead manipulation, or collaborative multi-bead manipulation, using pseudo-parallel executions. We demonstrate the flexibility of the design in terms of different coil sizes, DC current levels, and layout techniques. In one array module example, the size of a single coil is 30 μm × 30 μm and the full array occupies an area of 248 μm × 248 μm in 0.5 μm CMOS technology. The programmable DC current source supports 8 discrete levels up to 1.5 mA. The total power consumption of the entire module is 9 mW when running at full power.
authors.affiliation: Electrical and Computer Engineering Department, Michigan State University, East Lansing, MI 48824, USA. asd1815@msu.edu
authors.forename: F T
authors.initials: FT
authors.lastname: Abu-Nimeh
authors.forename: F M
authors.initials: FM
authors.lastname: Salem
mesh_terms: D056656:Lab-On-A-Chip Devices; D060526:Magnetic Fields; D008962:Models, Theoretical