title: Effect of periodontal therapy on metabolic control and levels of IL-6 in the gingival crevicular fluid in type 2 diabetes mellitus.
abstract: BACKGROUND
  The aim of this study was to compare the efficacy of metabolic control and levels of interleukin 6 (IL-6) in gingival crevicular fluid after periodontal therapy in type 2 diabetes mellitus (DM) and nondiabetic (NDM) patients.
  
  
  METHODS
  This study was performed in 20 subjects (10 type 2 DM and 10 NDM patients with generalized chronic periodontal disease. Both groups were recorded for clinical parameters (plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR) and clinical attachment level (CAL)), metabolic control (fasting glucose levels, glycated a-hemoglobin (HbA1c), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TR)), and IL-6 levels at baseline and 3 months after periodontal treatment.
  
  
  RESULTS
  DM and NDM patients revealed significant statistical reductions for clinical parameters (P < 0.05, RM ANOVA) after 3 months. DM group had improvements on HbA1c and had significant statistical increased of TRG (P < 0.05, RM ANOVA) after 3 months. No differences of LDL/HDL and IL-6 levels were found after 3 months in both groups.
  
  
  CONCLUSIONS
  DM group presented a significant reduction of HbA1c levels after periodontal therapy. However, TRG levels increased after 3 months, which suggest more confirmatory studies to investigate if these results will be repeated in other studies.
authors.affiliation: Department of Periodontology, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil.
authors.forename: Gabriela Alessandra da Cruz Galhardo
authors.initials: GA
authors.lastname: Camargo
authors.forename: Meyriane de Andrade
authors.initials: Mde A
authors.lastname: Lima
authors.forename: Tânia Vieira
authors.initials: TV
authors.lastname: Fortes
authors.forename: Cristiane Salgado
authors.initials: CS
authors.lastname: de Souza
authors.forename: Amelia Maria
authors.initials: AM
authors.lastname: de Jesus
authors.forename: Roque Pacheco
authors.initials: RP
authors.lastname: de Almeida
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D055113:Chronic Periodontitis / Q000276:immunology / Q000628:therapy*; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000276:immunology*; D005889:Gingival Recession / Q000145:classification / Q000628:therapy; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008875:Middle Aged; D009910:Oral Hygiene / Q000193:education; D017622:Periodontal Attachment Loss / Q000145:classification / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000628:therapy; D016745:Root Planing / Q000379:methods; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D015850:Interleukin-6; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; C508600:IL6 protein, human