title: Does oxybutynin hydrochloride cause arrhythmia in children with bladder dysfunction?
abstract: OBJECTIVE
  Pediatric surgeons frequently encounter children presenting with voiding dysfunction symptoms, including urgency, frequency, and incontinence. Antimuscarinic agents Oxybutynin) are the main drugs used to treat patients with overactive bladder (OAB) syndrome, defined as urgency, with or without urgency incontinence, usually with increased daytime frequency and nocturia. Increased QT dispersion is known to be the cause of ventricular arrhythmia in various systemic diseases and leads to increased mortality and morbidity.
  
  
  METHODS
  This study represents a subset of a complete data set, considering only those children aged admitted to the Pediatric Surgery and Pediatric Nephrology Clinics during the period January 2011 to July 2012.
  
  
  RESULTS
  In this study, we have determined that the QT interval changes significantly depending on the use of oxybutynin. The QT changes increased cardiac arrhythmia in children.
  
  
  CONCLUSIONS
  For this reason, children using such drugs should be closely monitored for cardiac arrhythmia.
authors.affiliation: Department of Pediatric Surgery, University of Selcuk, Selcuklu Medical Faculty, Konya, Turkey. driciftci@yahoo.com
authors.forename: Ilihan
authors.initials: I
authors.lastname: Ciftci
authors.forename: Derya
authors.initials: D
authors.lastname: Arslan
authors.forename: Harun
authors.initials: H
authors.lastname: Peru
authors.forename: Derya
authors.initials: D
authors.lastname: Cimen
authors.forename: Bulent
authors.initials: B
authors.lastname: Oran
authors.forename: Metin
authors.initials: M
authors.lastname: Gunduz
mesh_terms: D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D008333:Mandelic Acids; D018727:Muscarinic Antagonists; C005419:oxybutynin