title: [Application of nitrous oxide / oxygen inhalation sedation in tooth extraction of elderly patients with hypertension].
abstract: OBJECTIVE
  To investigate the safety and efficacy of nitrous oxide/oxygen inhalation sedation assisted in elderly hypertensive patients under local anesthesia during tooth extraction.
  
  
  METHODS
  Forty elderly patients (age≥70 years) with hypertension who needed tooth extraction with electrocardiographic monitoring were selected, and divided into experimental and control groups randomly, with 20 patients in each group. The experimental group was treated with nitrous oxide/oxygen inhalation sedation and local anesthesia for surgery, the control group underwent tooth extraction under local anesthesia. Heart rate, blood pressure, as well as differences of operative time in all groups before surgery, during operation and after surgery were observed and compared. SPSS 11.0 software package was used for statistical analysis.
  
  
  RESULTS
  The intraoperative HR, BP of patients in the control group was significantly higher than those of patients in the experimental group (P<0.05). HR, BP were relatively stable during the whole procedure in the experimental group. Compared with the control group, surgery was significantly longer in the experimental group (P<0.05). The difference was statistically significant.
  
  
  CONCLUSIONS
  Nitrous oxide/oxygen inhalation sedation assisted local anesthesia can be a safe and effective anesthetic method in tooth extraction of elderly patients with hypertension. Supported by Medical Science and Technology Progress Project of Nanjing City(YKK11040).
authors.affiliation: Department of Anesthesiology, Nanjing University Medical School, Nanjing, Jiangsu Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shao
authors.forename: Xin-he
authors.initials: XH
authors.lastname: Wang
authors.forename: Rong-xiang
authors.initials: RX
authors.lastname: Su
authors.forename: Ying-chun
authors.initials: YC
authors.lastname: Dong
authors.forename: Gang
authors.initials: G
authors.lastname: Li
mesh_terms: D000368:Aged; D000766:Anesthesia, Dental; D018685:Anesthetics, Inhalation; D006801:Humans; D006973:Hypertension; D009609:Nitrous Oxide; D010100:Oxygen; D014081:Tooth Extraction
chemical_list: D018685:Anesthetics, Inhalation; D009609:Nitrous Oxide; D010100:Oxygen