title: [A case of metastatic gastric cancer secondary to pancreatic neuroendocrine tumor fifteen years after distal pancreatectomy].
abstract: A 56-year-old man underwent distal pancreatectomy in July 1997, and chemotherapy was administered as adjuvant therapy. The histopathological diagnosis was a neuroendocrine tumor of the pancreas, NET G2 (Ki-67 labeling index: 3%), T2N0M0 stage IB, according to the TNM classification. In July 2011, follow-up endoscopic examination showed a submucosal tumor covered with almost normal gastric mucosa in the posterior wall of the upper stomach. Endoscopic ultrasound showed a heterogeneous-echoic submucosal tumor present at both the submucosal layer and the proper muscle layer. Abdominal enhanced CT revealed a 3-cm-diameter enhanced mass in the posterior wall of the upper stomach. We performed local resection of the gastric posterior wall. The histopathological diagnosis was a metastatic gastric tumor secondary to a pancreatic endocrine tumor, NET G2 (Ki-67 labeling index: 10%). In this paper, we report a rare case of metastatic gastric cancer secondary to a pancreatic neuroendocrine tumor 15 years after the first operation, together with a review of the literature.
authors.affiliation: Department of Surgery, Division of Digestive Surgery, Kyoto Prefectural University of Medicine. ponkino@koto.kpu-m.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Kinoshita
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Konishi
authors.forename: Shuhei
authors.initials: S
authors.lastname: Komatsu
authors.forename: Satoru
authors.initials: S
authors.lastname: Yasukawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shiozaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kubota
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yasuda
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Konishi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kishimoto
authors.forename: Eiichi
authors.initials: E
authors.lastname: Konishi
authors.forename: Akio
authors.initials: A
authors.lastname: Yanagisawa
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000473:pathology* / Q000601:surgery*; D010180:Pancreatectomy; D013274:Stomach Neoplasms / Q000556:secondary*; D013997:Time Factors