title: [Granulocyte-colony stimulating factor-producing urothelial carcinoma of the renal pelvis : a case report].
abstract: A 43-year-old woman was referred to our hospital for fever, general fatigue and left flank abdominal pain during the last two weeks. A blood test showed severe inflammation, and computed tomography (CT) study of the abdomen with intravenous contrast revealed swelling and irregular enhancement in the upper left kidney. Initially, we diagnosed it as xanthogranulomatous pyelonephritis and treated it with antibiotics. A percutaneous renal biopsy was performed because the white blood cell count remained elevated after the treatment. Histopathologic examination revealed a carcinoma. Therefore, we performed left nephroureterectomy. The diagnosis was high grade urothelial carcinoma of the renal pelvis, and it stained positive by immunohistochemical staining using anti-granulocyte-colony stimulating factor (G-CSF). The serum G-CSF level was also elevated on the same day. The patient received chemotherapy but, died 9 months after surgery. A G-CSF-producing urothelial carcinoma of the renal pelvis is known to have a poor prognosis in the Japanese literature. It is important to closely monitor a G-CSF producing tumor, when a patient shows severe inflammation, but no infection.
authors.affiliation: The Department of Urology, Sakai Hospital Kinki University, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Oki
authors.forename: Koichi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nose
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Nishioka
authors.forename: Shunji
authors.initials: S
authors.lastname: Maekura
authors.forename: Ken
authors.initials: K
authors.lastname: Ochiai
authors.forename: Eri
authors.initials: E
authors.lastname: Banno
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology; D007682:Kidney Pelvis; D019459:Urothelium / Q000473:pathology
chemical_list: D016179:Granulocyte Colony-Stimulating Factor