title: A sub-mW fully-integrated pulse oximeter front-end.
abstract: This paper presents the implementation of the first fully integrated pulse oximeter front-end with a power consumption lower than 1 mW. This is enabled by system- and block-level noise optimisation, also detailed in the manuscript. The proposed design features an analogue feedback loop that enables fast and accurate regulation of the detected photocurrent level and a serial-to-parallel interface allowing for extensive programmability of several operation parameters. The front-end was fabricated in the AMS 0.35 μm technology and occupies an area of 1.35 mm(2). Extensive measured results, both electrical and physiological from human subjects are reported, demonstrating an estimated SNR of 39 dB and ability to detect 2% changes in SpO2, similar to commercial pulse oximeters. This is despite the constrained power consumption which amounts to 0.31 mW for the LEDs and 0.53 mW for the rest of the front-end from a 3.3 V supply. Statistical results from 20 chips verify good matching across the Red and Infrared channels of the front-end and the accurate operation of the proposed analogue feedback loop.
authors.affiliation: Department of Bioengineering, Imperial College London, London SW7 2AZ, UK. glarosk@gmail.com
authors.forename: Konstantinos N
authors.initials: KN
authors.lastname: Glaros
authors.forename: Emmanuel M
authors.initials: EM
authors.lastname: Drakakis
mesh_terms: D000328:Adult; D000669:Amplifiers, Electronic; D001698:Biomedical Engineering; D002138:Calibration; D011211:Electric Power Supplies; D004867:Equipment Design; D005246:Feedback; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D010092:Oximetry / Q000295:instrumentation*; D017156:Photoplethysmography; D015203:Reproducibility of Results; D012119:Respiration; D012542:Scattering, Radiation; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D012984:Software; D055815:Young Adult