title: Tenofovir-associated Fanconi syndrome in patients with chronic hepatitis B monoinfection.
abstract: Tenofovir disoproxil fumarate (TDF) is increasingly used in patients with chronic hepatitis B (CHB) infection. Although associated with renal toxicity in HIV-infected patients, renal dysfunction has been reported rarely in the monoinfected CHB population. To date, TDF-associated Fanconi syndrome has not been reported. Here, we present two cases of TDF-associated Fanconi syndrome with rapid resolution after its cessation. We then discuss risk factors for TDF nephrotoxicity and its implications for screening for renal disease in those patients with CHB monoinfection on TDF, and the use of TDF in at-risk populations.
authors.affiliation: Renal Unit, Royal Prince Alfred Hospital, Sydney, Australia. david.gracey@sswahs.nsw.gov.au.
authors.forename: David M
authors.initials: DM
authors.lastname: Gracey
authors.forename: Paul
authors.initials: P
authors.lastname: Snelling
authors.forename: Paul
authors.initials: P
authors.lastname: McKenzie
authors.forename: Simone I
authors.initials: SI
authors.lastname: Strasser
mesh_terms: D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D010710:Phosphates / Q000097:blood; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D000068698:Tenofovir
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D010710:Phosphates; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir; D003404:Creatinine; D000225:Adenine