title: Ovarian carcinoma associated with endometriosis.
abstract: OBJECTIVE
  Previous studies have suggested an association between endometriosis and development of ovarian cancer. A study was performed to evaluate the cases of ovarian carcinoma associated with endometriosis.
  
  
  METHODS
  The study includes patients with ovarian carcinoma associated with endometriosis diagnosed between 2000 and 2010 at Hacettepe University Hospital, Ankara, Turkey. A total of 1086 patients who underwent surgical staging for ovarian carcinoma were analyzed retrospectively for the presence of histologically documented endometriosis. The clinical and pathological characteristics of 45 ovarian carcinoma patients associated with endometriosis were evaluated including histologic subtype, stage and grade.
  
  
  RESULTS
  Ovarian carcinoma was found to be associated with endometriosis in 4.1% (45/1086) of the cases. Of them, 17 patients (37.8%) had clear cell, 15 (33.3%) had endometrioid, 6 (13.3%) had serous papillary, 4 (8.9%) had mucinous and the remaining 3 patients had an undifferentiated subtype of ovarian carcinoma. Twenty-three (51.1%) patients had stage I, 4 (8.9%) had stage II and 18 (40.0%) had stage III disease. The frequency of coexistence of endometriosis was 20.4% (17/83) for clear cell carcinoma and 9.3% (15/161) for endometrioid cell carcinoma.
  
  
  CONCLUSIONS
  Only a small proportion of ovarian cancer cases were found to be associated with endometriosis. Endometriosis was most frequently associated with clear cell and endometrioid types of ovarian carcinoma. Ovarian carcinoma associated with endometriosis seems to represent a distinct disease entity with different histological subtypes, early presentation and a relatively favorable outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Electronic address: gokhan.boyraz@gmail.com.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Boyraz
authors.forename: Ilker
authors.initials: I
authors.lastname: Selcuk
authors.forename: Aslıhan
authors.initials: A
authors.lastname: Yazıcıoğlu
authors.forename: Zafer Selçuk
authors.initials: ZS
authors.lastname: Tuncer
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000209:etiology* / Q000401:mortality; D004715:Endometriosis / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000401:mortality; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology
keywords: Clear cell; Endometrioid; Endometriosis; Ovarian cancer