title: Pu-erh tea suppresses diet-induced body fat accumulation in C57BL/6J mice by down-regulating SREBP-1c and related molecules.
abstract: Although pu-erh tea has been shown to suppress hyperlipidemia, it is unclear how it modulates fatty acid synthase expression in mice fed on a high-fat diet. We investigated the effects of a pu-erh tea extract (PTE) on diet-induced body fat accumulation. C57BL/6J mice were fed a control diet, a high-fat diet (HFD), and HFD supplemented with 0.225% or 0.45% PTE for 70 d. Supplementation with PTE reduced the body weight gain, and the abdominal and liver fat accumulation. A significant difference in the triglyceride level were observed between the HFD control and HFD+0.45% PTE groups. A PTE intake tended to decrease sterol regulatory element-binding protein (SREBP)-1c and fatty acid synthase (FAS) mRNA expression in the liver of the mice. These findings indicate that PTE reduced lipogenesis by down-regulating SREBP-1c and related molecules, leading to the suppression of body fat accumulation.
authors.affiliation: Department of Food and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizouka 422-8526, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shimamura
authors.forename: Miyuki
authors.initials: M
authors.lastname: Yoda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakakibara
authors.forename: Kojiro
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Shuichi
authors.initials: S
authors.lastname: Masuda
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D001628:Beverages; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004032:Diet / Q000009:adverse effects*; D015536:Down-Regulation / Q000187:drug effects*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D008049:Lipase / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000188:drug therapy; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*
chemical_list: D001647:Bile Acids and Salts; D010936:Plant Extracts; D012333:RNA, Messenger; D051780:Sterol Regulatory Element Binding Protein 1; D002784:Cholesterol; D008049:Lipase