title: Anti-influenza virus activity of two extracts of the blackcurrant (Ribes nigrum L.) from New Zealand and Poland.
abstract: We investigated the inhibitory effect of extracts of blackcurrant (Ribes nigrum L.) from New Zealand and Poland on 4 strains of influenza virus (IFV) by the inhibition of virus adsorption; pandemic flu from 2009-2010 (IFV-AH1pdm), Hong Kong flu (IFV-AH3), oseltamivir phosphate-resistant Russian flu (IFV-AH1tamr) and influenza virus type B (IFV-B). The inhibitory effect of the extracts of blackcurrant or blueberry on the infectivity of the virion were evaluated by the inhibition of virus adsorption on the cell surface (adsorption-inhibitory assay). Three percent solutions of the blackcurrant extracts from New Zealand and Poland were enough to disinfect more than half of IFV-AH1pdm and IFV-B, and 10% solutions from both regions disinfected all IFV strains completely. Our previous study showed that the antiviral effect of the blackcurrant differed according to viral species. Here we showed that although the antiviral effect of Blackcurrant was slightly different within viral strains from one species, the extract of Blackcurrant could disinfect all of 4 IFV strains we examined. The extracts of blackcurrant showed definite potential for use as a disinfectant and antiseptic agent to prevent IFV infection.
authors.affiliation: Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Ikuta
authors.forename: Katsumi
authors.initials: K
authors.lastname: Mizuta
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suzutani
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004285:Dogs; D009520:New Zealand; D009975:Orthomyxoviridae / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D011044:Poland; D031965:Ribes
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts