title: Hydroxysafflor yellow A ameliorates homocysteine-induced Alzheimer-like pathologic dysfunction and memory/synaptic disorder.
abstract: Homocysteine (Hcy) could induce amyloid β (Aβ) accumulation, synaptic dysfunction, and memory impairment as seen in Alzheimer disease (AD), the most prevalent neurodegenerative disorder, which affects more than 25 million people worldwide. Here we investigated the protective effect of hydroxysafflor yellow A (HSYA) on Hcy-induced Aβ accumulation, synaptic dysfunction, and learning and memory deficits. Rats were randomly divided into four groups: Control group, which received normal saline (NS); Hcy group, which received a daily vena caudalis injection of Hcy (400 μg/kg per day); Hcy+HSYA group, which received the same amount of Hcy plus 6 mg/kg per day HSYA intraperitoneally; and HSYA group, which received 6 mg/kg per day HSYA intraperitoneally for 2 weeks. Results showed that simultaneous supplementation of HSYA significantly attenuated Aβ accumulation, improved synaptic function, and reversed Hcy-induced cognitive impairment. Our data suggest that HSYA might be a promising therapeutic candidate for attenuating Hcy-induced AD-like pathological and behavioral deficits.
authors.affiliation: 1 Department of Neurology, First Hospital of Lanzhou University , Lanzhou, China .
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Lu
authors.forename: Yu
authors.initials: Y
authors.lastname: Luo
authors.forename: Zhong-Fang
authors.initials: ZF
authors.lastname: He
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Bo-Ling
authors.initials: BL
authors.lastname: Yan
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Qin
authors.initials: Q
authors.lastname: Yu
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D015153:Blotting, Western; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D006710:Homocysteine / Q000009:adverse effects*; D008297:Male; D018782:Maze Learning; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control*; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000187:drug effects*
chemical_list: D011809:Quinones; D006710:Homocysteine; C085278:hydroxysafflor yellow A; D002599:Chalcone