title: Insight from γC1 protein model for implication in cotton leaf curl disease.
abstract: DNA γ is approximately half of the size of Begomovirus DNA. It encodes a γC1 gene that is conserved in position and size. This gene has the capacity to encode a 13 to 14 kDa protein comprising 118 amino acid residues. It has been shown earlier that γC1 protein is necessary for inducing symptoms of cotton leaf curl disease. The structure for γC1 (CLCuDγ01-Pakistan) is still unknown. Therefore, a model of γC1 (CLCuDγ01-Pakistan) was developed using DoBo and I-TASSER servers followed by validation by PROCHECK and VERIFY 3D servers. The developed model provides an insight in a role for this multifunctional protein in causing Cotton Leaf Curl Disease (CLCuD). A possible function of this protein might be the suppression of RNAsilencing in cotton plants.
authors.affiliation: Illinois Informatics Institute, University of Illinois, Urbana-Champaign, Illinois, U.S.A.
authors.forename: Khuram
authors.initials: K
authors.lastname: Shahzad
authors.forename: Abdul
authors.initials: A
authors.lastname: Hai
authors.forename: Nadeem
authors.initials: N
authors.lastname: Kizilbash
authors.forename: Jawaria
authors.initials: J
authors.lastname: Ambreen
authors.forename: Jamal
authors.initials: J
authors.lastname: Alruwaili
keywords: Cotton Leaf Curl Disease; DNA γ; RNA silencing; protein structure prediction; threading; γC1 gene