title: Assessment of test methods evaluating mucoadhesive polymers and dosage forms: an overview.
abstract: Oral mucoadhesive preparations have gained increasing importance in the last decades, by reason of numerous advantages like easy application, discrete handling and no swallowing of the drug product. Pharmacopoeial methods to study mucoadhesion are not available so far, despite the new monograph for oromucosal preparations is valid since the European Pharmacopoeia 7.4 (2012) including a chapter on mucoadhesive preparations. Several mucoadhesion test methods are reviewed concerning the applicability for various polymers, different drug dosage forms and comparability of experimental set-ups. Different test methods and experimental set-ups lead to huge differences regarding the results.
authors.affiliation: Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Woertz
authors.forename: Maren
authors.initials: M
authors.lastname: Preis
authors.forename: Jörg
authors.initials: J
authors.lastname: Breitkreutz
authors.forename: Peter
authors.initials: P
authors.lastname: Kleinebudde
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003102:Colloids / Q000737:chemistry; D016503:Drug Delivery Systems; D004867:Equipment Design; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D018625:Microscopy, Atomic Force; D009061:Mouth Mucosa / Q000187:drug effects*; D011108:Polymers / Q000737:chemistry*; D012212:Rheology; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D003102:Colloids; D011108:Polymers
keywords: Mucoadhesion; Mucoadhesive preparation; Oral mucosa; Oromucosal preparation; Polymer; Texture Analyser