title: Redox-sensitive shell-crosslinked polypeptide-block-polysaccharide micelles for efficient intracellular anticancer drug delivery.
abstract: Redox-responsive SCMs based on amphiphilic PBLG-b-dextran with good biocompatibility are synthesized and used for efficient intracellular drug delivery. The molecular structures and SCMs characteristics are characterized by (1) H NMR, FT-IR, TEM, and DLS. The hydrodynamic radius of SCMs increases gradually in PBS due to the cleavage of disulfide bond in micellar shell caused by the presence of GSH. The encapsulation efficiency and release kinetics of DOX are investigated. The fastest DOX release is observed under intracellular-mimicking reductive environments. An MTT assay demonstrates that DOX-loaded SCMs show higher cellular proliferation inhibition against GSH-OEt pretreated HeLa and HepG2 than that of the non-pretreated and BSO-pretreated ones.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Zhang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.forename: Fenghua
authors.initials: F
authors.lastname: Shi
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Xiao
authors.forename: Jianxun
authors.initials: J
authors.lastname: Ding
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhuang
authors.forename: Chaoliang
authors.initials: C
authors.lastname: He
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry*; D003911:Dextrans / Q000138:chemical synthesis / Q000737:chemistry; D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D057446:Hydrodynamics; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D010084:Oxidation-Reduction / Q000187:drug effects; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D003911:Dextrans; D008823:Micelles; D010455:Peptides; D011134:Polysaccharides; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid; D004317:Doxorubicin
keywords: biocompatibility; drug delivery; micelles; redox-sensitive