title: T2D@ZJU: a knowledgebase integrating heterogeneous connections associated with type 2 diabetes mellitus.
abstract: Type 2 diabetes mellitus (T2D), affecting >90% of the diabetic patients, is one of the major threats to human health. A comprehensive understanding of the mechanisms of T2D at molecular level is essential to facilitate the related translational research. Here, we introduce a comprehensive and up-to-date knowledgebase for T2D, i.e. T2D@ZJU. T2D@ZJU contains three levels of heterogeneous connections associated with T2D, which is retrieved from pathway databases, protein-protein interaction databases and literature, respectively. In current release, T2D@ZJU contains 1078 T2D related entities such as proteins, protein complexes, drugs and others together with their corresponding relationships, which include 3069 manually curated connections, 14,893 protein-protein interactions and 26,716 relationships identified by text-mining technology. Moreover, T2D@ZJU provides a user-friendly web interface for users to browse and search data. A Cytoscape Web-based interactive network browser is available to visualize the corresponding network relationships between T2D-related entities. The functionality of T2D@ZJU is shown by means of several case studies. Database URL: http://tcm.zju.edu.cn/t2d.
authors.affiliation: Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Yang
authors.forename: Jihong
authors.initials: J
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Leihong
authors.initials: L
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Xing
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Fan
authors.forename: Yiyu
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D003196:Computer Graphics; D057225:Data Mining; D019992:Databases as Topic; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005786:Gene Expression Regulation; D024003:HMGA Proteins / Q000378:metabolism; D006801:Humans; D020407:Internet; D051188:Knowledge Bases; D060066:Protein Interaction Maps / Q000235:genetics; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism; D059467:Transcriptome / Q000235:genetics; D014584:User-Computer Interface
chemical_list: D024003:HMGA Proteins; D050826:Suppressor of Cytokine Signaling Proteins