title: Tissue engineering: using collagen type I matrix for bone healing of bone defects.
abstract: Among the many tissues in the human body, bone has been considered as a powerful marker for regeneration and its formation serves as a prototype model for tissue engineering based on morphogenesis. Therefore, collagen type I is one of the most useful biomaterials used in tissue engineering as extracellular matrix components capable to promote bone healing. The literature reveals excellent biocompatibility and safety due to its biological characteristics, such as biodegradability and weak antigenicity, making collagen type I the primary resource in medical applications. Thus, it was also used for tissue engineering including skin replacement, bone substitutes, and artificial blood vessels and valves. The authors describe the treatment of an abscessed apical periodontal cyst and show good outcomes of bone healing, using tissue engineering, as collagen type I matrix.
authors.affiliation: Clinic & Surgery Department, Alfenas Dental School, Federal University of Alfenas-UNIFAL, Minas Gerais, Brazil.
authors.forename: Marina Reis
authors.initials: MR
authors.lastname: Oliveira
authors.forename: Elisa das Graças
authors.initials: Ed
authors.lastname: Martins
authors.forename: Ronaldo
authors.initials: R
authors.lastname: Célio-Mariano
authors.forename: Celso Koogi
authors.initials: CK
authors.lastname: Sonoda
authors.forename: Idelmo
authors.initials: I
authors.lastname: Rangel Garcia
authors.forename: Willian Morais
authors.initials: WM
authors.lastname: de Melo
mesh_terms: D000328:Adult; D001861:Bone Regeneration; D024042:Collagen Type I / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery*; D010509:Periodontal Cyst / Q000601:surgery*; D023822:Tissue Engineering; D014945:Wound Healing / Q000502:physiology
chemical_list: D024042:Collagen Type I