title: Biosynthetic origins of menisporopsin A.
abstract: Menisporopsin A, produced by Menisporopsis theobromae, shows antimalarial, antimycobacterial, and cytotoxic activities. Here, we report the first (13)C incorporations at individual carbons of menisporopsin A using sodium [1-(13)C] and [2-(13)C] acetate. This result indicates that each of the subunits of the pentalactone menisporopsin A is assembled by a polyketide synthase.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Ladyaow, Chatuchak, Bangkok 10900, Thailand.
authors.forename: Pakorn
authors.initials: P
authors.lastname: Wattana-amorn
authors.forename: Punika
authors.initials: P
authors.lastname: Juthaphan
authors.forename: Maturin
authors.initials: M
authors.lastname: Sirikamonsil
authors.forename: Ajaraporn
authors.initials: A
authors.lastname: Sriboonlert
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Simpson
authors.forename: Ngampong
authors.initials: N
authors.lastname: Kongkathip
mesh_terms: D000900:Anti-Bacterial Agents; D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism*; D001203:Ascomycota / Q000737:chemistry*; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D048630:Polyketide Synthases / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D018942:Macrolides; C485925:menisporopsin A; D048630:Polyketide Synthases