title: Liver and plasma nesfatin-1 responses to 6 weeks of treadmill running with or without zizyphus jujuba liquid extract in female rat.
abstract: BACKGROUND
  Nesfatin-1 is a protein derived from a precursor molecule of the nucleobindin-2 gene, and acts as an anorexigenic peptide on food intake behavior, and its level isinfluenced by nutritional status, food composition [fat and carbohydrate (CHO)], and physical exercise.
  
  
  OBJECTIVE
  The aim of this study was to investigate the effects of 6 weeks of treadmill running (at high intensity) program with and without zizyphus jujuba (high carbohydrate content) crud extraction on liver nesfatin-1, ATP, glycogen, and its plasma concentrations in female rats.
  
  
  METHODS
  Twenty-eight Wistar female rats (6-8 weeks old100-120 g of weight) were randomly assigned to saline-control (SC), saline-training (ST), zizyphus jujuba-control (ZJC), and zizyphus jujuba-training (ZJT) groups. Rats ran on a motor-driven treadmill at 35 m/min, 60 min/day, 5 days/week for 6 weeks. Animals received ZJ extraction and saline at the dose of 1.25 mL/100g of body weight. Seventy-two hours after the last training session rats were killed, a portion of liver excited, and plasma was collected for nesfatin-1, ATP, and glycogen measurements. A one-way ANOVA method, and Pearson correlation were employed. P < 0.05 was considered as significant.
  
  
  RESULTS
  A higher and significant liver nesfatin-1 level was found in ZJ groups (p < 0.005), but plasma nesfatin-1 responded differently. Changes in liver nesfatin-1 were accompanied with an increase in liver glycogen,but not ATP contents.
  
  
  CONCLUSIONS
  The Findings indicate that higher liver nesfatin-1 and glycogen content by ZJ extraction might be due to the ZJ high CHO content, and it could be consideredas an anti-appetite herb.
authors.affiliation: Exercise Biochemistry Division, Department of Physical Education and Sport Sciences, University of Mazandarn, Baboulsar, IR Iran.
authors.forename: Abbass
authors.initials: A
authors.lastname: Ghanbari Niaki
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mohammadi Joojadeh
authors.forename: Navabeh
authors.initials: N
authors.lastname: Zare Kookandeh
authors.forename: Safar
authors.initials: S
authors.lastname: Najafi
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Chaichi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Rodbari
authors.forename: Hasan
authors.initials: H
authors.lastname: Bayat
keywords: Endurance Training; Nesfatin-1; Zizyphus Jujuba