title: A multiprotein complex negatively regulates RAG GTPases and mTORC1.
abstract: The GATOR complex, composed of GATOR1/2 subunits, inhibits amino acid sensing by RAGs and mTORC1.
mesh_terms: D001343:Autophagy; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases; D020558:GTP Phosphohydrolases