title: Persistence of yellow fever vaccine-induced antibodies after solid organ transplantation.
abstract: Immunization using live attenuated vaccines represents a contra-indication after solid organ transplantation (SOT): consequently, transplant candidates planning to travel in countries where yellow fever is endemic should be vaccinated prior to transplantation. The persistence of yellow fever vaccine-induced antibodies after transplantation has not been studied yet. We measured yellow-fever neutralizing antibodies in 53 SOT recipients vaccinated prior to transplantation (including 29 kidney recipients and 18 liver recipients). All but one (98%) had protective titers of antibodies after a median duration of 3 years (min.: 0.8, max.: 21) after transplantation. The median antibody level was 40 U/L (interquartile range: 40-80). For the 46 patients with a known or estimated date of vaccination, yellow-fever antibodies were still detectable after a median time of 13 years (range: 2-32 years) post-immunization. Our data suggest there is long-term persistence of antibodies to yellow fever in SOT recipients who have been vaccinated prior to transplantation.
authors.affiliation: Assistance publique-hôpitaux de Paris, CHU Bicêtre, Service de maladies infectieuses et tropicales, Centre de vaccinations internationales, Paris, Le Kremlin-Bicêtre, France.
authors.forename: B
authors.initials: B
authors.lastname: Wyplosz
authors.forename: C
authors.initials: C
authors.lastname: Burdet
authors.forename: H
authors.initials: H
authors.lastname: François
authors.forename: A
authors.initials: A
authors.lastname: Durrbach
authors.forename: J C
authors.initials: JC
authors.lastname: Duclos-Vallée
authors.forename: M-F
authors.initials: MF
authors.lastname: Mamzer-Bruneel
authors.forename: P
authors.initials: P
authors.lastname: Poujol
authors.forename: O
authors.initials: O
authors.lastname: Launay
authors.forename: D
authors.initials: D
authors.lastname: Samuel
authors.forename: D
authors.initials: D
authors.lastname: Vittecoq
authors.forename: P H
authors.initials: PH
authors.lastname: Consigny
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D011446:Prospective Studies; D014181:Transplantation Immunology; D022341:Yellow Fever Vaccine / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D022341:Yellow Fever Vaccine
keywords: Antibody persistence; immunization; solid organ transplantation; yellow-fever vaccine