title: Emerging trends in in vivo neurochemical monitoring by microdialysis.
abstract: Mapping chemical dynamics in the brain of live subjects is a challenging but highly rewarding goal because it allows neurotransmitter fluctuations to be related to behavior, drug effects, and disease states. A popular method for such measurements is microdialysis sampling coupled to analytical measurements. This method has become well-established for monitoring low molecular weight neurotransmitters, metabolites, and drugs, especially in pharmacological and pharmacokinetic studies. Recent technological developments which improve the temporal and spatial resolution of the methods will enable it to be used for studying behavior and small brain nuclei. Better assays allow monitoring more neurotransmitters simultaneously. Extension to analysis of aggregating proteins like amyloid β is proving extremely useful for uncovering the roles of these molecules and how they contribute to neurodegenerative diseases.
authors.affiliation: Departments of Chemistry and Pharmacology, University of Michigan, Ann Arbor, MI, United States. Electronic address: rtkenn@umich.edu.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Kennedy
mesh_terms: D016229:Amyloid beta-Peptides / Q000032:analysis; D000818:Animals; D001923:Brain Chemistry; D006801:Humans; D017551:Microdialysis / Q000295:instrumentation / Q000379:methods*; D009448:Neurochemistry / Q000295:instrumentation / Q000379:methods*; D018377:Neurotransmitter Agents / Q000032:analysis
chemical_list: D016229:Amyloid beta-Peptides; D018377:Neurotransmitter Agents