title: Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment.
abstract: The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1(-/-) model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1(-/-) animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed.
authors.affiliation: GReD laboratory, CNRS UMR 6293 - INSERM U1103 - Clermont Université, Aubière, France.
authors.forename: Aicha
authors.initials: A
authors.lastname: Jrad-Lamine
authors.forename: Joelle
authors.initials: J
authors.lastname: Henry-Berger
authors.forename: Christelle
authors.initials: C
authors.lastname: Damon-Soubeyrand
authors.forename: Fabrice
authors.initials: F
authors.lastname: Saez
authors.forename: Ayhan
authors.initials: A
authors.lastname: Kocer
authors.forename: Laurent
authors.initials: L
authors.lastname: Janny
authors.forename: Hanae
authors.initials: H
authors.lastname: Pons-Rejraji
authors.forename: David H
authors.initials: DH
authors.lastname: Munn
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Mellor
authors.forename: Najoua
authors.initials: N
authors.lastname: Gharbi
authors.forename: Rémi
authors.initials: R
authors.lastname: Cadet
authors.forename: Rachel
authors.initials: R
authors.lastname: Guiton
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Aitken
authors.forename: Joël R
authors.initials: JR
authors.lastname: Drevet
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D018925:Chemokines / Q000378:metabolism; D004822:Epididymis / Q000201:enzymology* / Q000276:immunology; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000502:physiology*; D007378:Interleukins / Q000378:metabolism; D007737:Kynurenine / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D018925:Chemokines; C583637:IDO1 protein, mouse; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007378:Interleukins; D007737:Kynurenine