title: Porous silicon advances in drug delivery and immunotherapy.
abstract: Biomedical applications of porous silicon include drug delivery, imaging, diagnostics and immunotherapy. This review summarizes new silicon particle fabrication techniques, dynamics of cellular transport, advances in the multistage vector approach to drug delivery, and the use of porous silicon as immune adjuvants. Recent findings support superior therapeutic efficacy of the multistage vector approach over single particle drug delivery systems in mouse models of ovarian and breast cancer. With respect to vaccine development, multivalent presentation of pathogen-associated molecular patterns on the particle surface creates powerful platforms for immunotherapy, with the porous matrix able to carry both antigens and immune modulators.
authors.affiliation: Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA; MD Anderson Cancer Center, Department of Surgical Oncology, 1515 Holcombe Blvd #444, Houston, TX, USA; The University of Texas Medical School at Houston, 6431 Fannin, Houston, TX, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Savage
authors.forename: Xuewu
authors.initials: X
authors.lastname: Liu
authors.forename: Steven A
authors.initials: SA
authors.lastname: Curley
authors.forename: Mauro
authors.initials: M
authors.lastname: Ferrari
authors.forename: Rita E
authors.initials: RE
authors.lastname: Serda
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001798:Blood Proteins / Q000378:metabolism; D016503:Drug Delivery Systems; D007167:Immunotherapy; D009369:Neoplasms / Q000628:therapy*; D016062:Porosity; D012825:Silicon / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D001798:Blood Proteins; D012825:Silicon