title: Comprehensive assessment of prognostic markers for sinonasal squamous cell carcinoma.
abstract: BACKGROUND
  Little is known about the molecular signature of the rare tumor sinonasal squamous cell carcinoma (SNSCC). The purpose of this study was to comprehensively assess various molecular biomarkers in SNSCC.
  
  
  METHODS
  We chose 13 markers for this study, which have been known as prognostic markers in head and neck squamous cell carcinoma. Expression of these markers was examined by either in situ hybridization or immunohistochemical methods on tissue microarrays made from 70 SNSCC specimens and 28 matched-pair normal tissues from patients who underwent surgical resection at our institution. Expression data were correlated with patient clinicopathologic parameters and survival.
  
  
  RESULTS
  Of the 13 markers, only epidermal growth factor receptor (EGFR) protein expression was associated with significantly shorter disease-free survival (DFS; p = .01307). EGFR expression was also associated with shorter overall survival (OS), but the difference was not statistically significant.
  
  
  CONCLUSIONS
  Targeted inhibition of tumor EGFR expression may be a new approach to treating SNSCC.
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Diana
authors.initials: D
authors.lastname: Bell
authors.forename: Garima
authors.initials: G
authors.lastname: Agarwal
authors.forename: Dianna
authors.initials: D
authors.lastname: Roberts
authors.forename: Tong-Xin
authors.initials: TX
authors.lastname: Xie
authors.forename: Adel
authors.initials: A
authors.lastname: El-Naggar
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Myers
authors.forename: Ehab Y
authors.initials: EY
authors.lastname: Hanna
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors
keywords: disease-free survival; epidermal growth factor receptor; prognostic markers; sinonasal squamous cell carcinoma; tissue microarrays