title: The action of aminoguanidine on the liver of trained diabetic rats.
abstract: BACKGROUND
  This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques.
  
  
  METHODS
  THE RATS USED IN THIS STUDY WERE DIVIDED INTO FIVE GROUPS: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine.
  
  
  RESULTS
  The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels.
  
  
  CONCLUSIONS
  Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin.
authors.affiliation: UNESP-University Estadual Paulista, Avenida 24 A, 1515, 13506-900, Rio Claro, SP CP 199, Brazil.
authors.forename: Edmara Tereza Meira
authors.initials: ET
authors.lastname: E Nico
authors.affiliation: UNESP-University Estadual Paulista, Avenida 24 A, 1515, 13506-900, Rio Claro, SP CP 199, Brazil.
authors.forename: Patrícia Rosa
authors.initials: PR
authors.lastname: de Oliveira
authors.affiliation: UNESP-University Estadual Paulista, Avenida 24 A, 1515, 13506-900, Rio Claro, SP CP 199, Brazil.
authors.forename: Leonardo Peres
authors.initials: LP
authors.lastname: de Souza
authors.affiliation: UNESP-University Estadual Paulista, Avenida 24 A, 1515, 13506-900, Rio Claro, SP CP 199, Brazil.
authors.forename: Franco Dani Campos
authors.initials: FD
authors.lastname: Pereira
authors.affiliation: UNESP-University Estadual Paulista, Avenida 24 A, 1515, 13506-900, Rio Claro, SP CP 199, Brazil.
authors.forename: Maria Andréia
authors.initials: MA
authors.lastname: Delbin
authors.affiliation: UNESP-University Estadual Paulista, Avenida 24 A, 1515, 13506-900, Rio Claro, SP CP 199, Brazil.
authors.forename: Angelina
authors.initials: A
authors.lastname: Zanesco
authors.affiliation: UNESP-University Estadual Paulista, Avenida 24 A, 1515, 13506-900, Rio Claro, SP CP 199, Brazil.
authors.forename: Maria Izabel
authors.initials: MI
authors.lastname: Camargo-Mathias
keywords: Aminoguanidine; Diabetes type 1; Liver; Physical exercises; Rats