title: The role of optical coherence tomography (OCT) in optic neuritis (ON).
abstract: Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and other neurologic disorders that affect the anterior visual pathway. Optical coherence tomography (OCT) is a non-invasive technique that allows imaging of the retinal layers. Our aim was to examine retinal nerve fiber layer (RNFL) thickness and macular volume (MV), measred by OCT in patients with history of optic neuritis (ON). Patients with chronic ON had significantly decreased mean RNFL thickness and total MV when compared to acute ON eyes, controls and unaffected fellow eyes. There was also statistically significant difference between two chronic groups, with lower values in group with history of acute ON. OCT provides us unique insight in structural changes in the anterior visual pathway, therefore it may complement our existing diagnostic tests and, as a potential outcome measure, help develop more effective therapeutic strategies for ON and MS patients.
authors.affiliation: University of Zagreb, Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia. bcerov@kbc-zagreb.hr
authors.forename: Branimir
authors.initials: B
authors.lastname: Cerovski
authors.forename: Marija Barisić
authors.initials: MB
authors.lastname: Kutija
authors.forename: Tomislav
authors.initials: T
authors.lastname: Vidović
authors.forename: Smiljka
authors.initials: S
authors.lastname: Popović-Suić
authors.forename: Sonja
authors.initials: S
authors.lastname: Jandroković
authors.forename: Rajko
authors.initials: R
authors.lastname: Kordić
authors.forename: Sania
authors.initials: S
authors.lastname: Vidas
mesh_terms: D000328:Adult; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D009412:Nerve Fibers / Q000473:pathology; D009902:Optic Neuritis / Q000175:diagnosis*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*