title: The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa.
abstract: Sequence variation in the asparagine/aspartate-rich domain of pfmdr1 in 215 isolates of Plasmodium falciparum from three African countries was compared with published data. The role of this domain in modulating antimalarial sensitivity has not been established. The pfmdr1 86Y allele was significantly associated with different configurations of the Asn/Asp-rich domain in West and East Africa. In Kenya, a specific form of the Asn/Asp-rich domain was significantly linked to the 86Y, 184Y, and 1246Y haplotype of pfmdr1.
authors.affiliation: Department of Immunology & Infection, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Okombo
authors.forename: Issaka
authors.initials: I
authors.lastname: Zongo
authors.forename: Nahla
authors.initials: N
authors.lastname: Gadalla
authors.forename: Teun
authors.initials: T
authors.lastname: Bousema
authors.forename: Khalid B
authors.initials: KB
authors.lastname: Beshir
authors.forename: Cally
authors.initials: C
authors.lastname: Roper
authors.forename: Rachel
authors.initials: R
authors.lastname: Hallett
authors.forename: Lynette Isabella
authors.initials: LI
authors.lastname: Ochola-Oyier
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Sutherland
mesh_terms: D000351:Africa, Eastern; D000354:Africa, Western; D000483:Alleles; D000595:Amino Acid Sequence; D004351:Drug Resistance / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology; D008969:Molecular Sequence Data; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D058974:Phylogeography; D010963:Plasmodium falciparum / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D017434:Protein Structure, Tertiary; D017422:Sequence Analysis, DNA
chemical_list: D027425:ATP-Binding Cassette, Sub-Family C Proteins; C513498:Mdr1 protein, Plasmodium falciparum