title: Pattern of aortic dilatation in different bicuspid aortic valve phenotypes and its association with aortic valvular dysfunction and elasticity.
abstract: OBJECTIVE
  We aim to study the pattern of aortic dilatation in different BAV phenotypes and to find any correlations between aortic dilatation, aortic elasticity and AS and/or AR in our local population.
  
  
  METHODS
  All BAV patients and controls were retrospectively studied. Aortic distensibility and stiffness index of the ascending aorta were calculated.
  
  
  RESULTS
  A total of 191 patients with BAV and 180 controls were enrolled. Aortic dilatation involving a single site was more common with dilatation involving only the ascending aorta (R-N phenotype) and aortic root (N-L phenotype). AR was most common in patients with N-L and R-L phenotypes and AS in R-N phenotype. Aortic elasticity had no correlation with the different BAV phenotypes.
  
  
  CONCLUSIONS
  There are different patterns of aortic dilatation in different BAV phenotypes, which may further contribute to the development of aortic stenosis or regurgitation. Aortic elasticity is independent of the BAV phenotypes and is impaired in BAV patients regardless of AS or AR severity.
authors.affiliation: Cardiology Department, National Heart Centre Singapore, Singapore.
authors.forename: Fei Qiong
authors.initials: FQ
authors.lastname: Huang
authors.affiliation: Cardiology Department, National Heart Centre Singapore, Singapore. Electronic address: tan.ju.le@nhcs.com.sg.
authors.forename: Ju
authors.initials: J
authors.lastname: Le Tan
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology; D001021:Aortic Valve / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000503:physiopathology; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D000082882:Bicuspid Aortic Valve Disease; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging / Q000503:physiopathology; D004548:Elasticity; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014463:Ultrasonography
keywords: AA; AR; AS; Aortic elasticity; Aortic valve regurgitation; Aortic valve stenosis; Asc Ao; BAV; Bicuspid aortic valve; DBP; DIS; MAP; SBP; SI; SOV; STJ; aortic annulus; aortic regurgitation; aortic stenosis; ascending aorta; bicuspid aortic valve; diastolic blood pressure; distensibility; mean blood pressure; sinotubular junction; sinuses of Valsalva; stiffness index; systolic blood pressure