title: The association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a northern Han Chinese population.
abstract: BACKGROUND
  We investigated the association between oxcarbazepine (OXC)-induced maculopapular eruption (MPE) and HLA-B alleles in a northern Han Chinese population, and conducted an analysis of clinical risk factors for OXC-MPE.
  
  
  METHODS
  Forty-two northern Han Chinese patients who had been treated with OXC in Changchun, China were genotyped. Among them were 14 cases with OXC-induced MPE; the remaining 28 were OXC-tolerant. The HLA-B allele frequencies of the normal control group were found in the Allele Frequency Net Database. Polymerase chain reaction-sequence specific primer( PCR-SSP )was used for HLA-B*1502 testing and direct sequencing for four-digit genotype determination.
  
  
  RESULTS
  Four-digit allele sequencing showed that there was no statistically significant difference in the frequency of the HLA-B*1502 allele between the OXC-MPE and OXC-tolerant controls (3.6% versus 7.5%, OR = 0.38, 95% CI = 0.04-3.40, P = 0.65), as well as between OXC-MPE and normal controls (3.6% versus 2.4%, OR = 1.54, 95% CI = 0.20-11.73, P = 0.49). However, a significant difference in the frequency of HLA-B*3802 alleles was found between the MPE group and normal controls (10.7% versus 1.9%, OR = 6.329, 95% CI = 1.783-22.460, P = 0.018). There was no significant difference in terms of age, gender, or final OXC dose between the OXC-MPE and OXC-tolerant groups.
  
  
  CONCLUSIONS
  There was no significant association between OXC-MPE and HLA-B*1502 in the northern Han Chinese population in our study. Instead, HLA-B*3802 was found to be a potential risk factor for OXC-MPE.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Jilin University, 71 Xinmin Street, Chang Chun, PR China.
authors.forename: Yu-Dan
authors.initials: YD
authors.lastname: Lv
authors.forename: Fu-Li
authors.initials: FL
authors.lastname: Min
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liao
authors.forename: Na
authors.initials: N
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Zeng
authors.forename: Di-Hui
authors.initials: DH
authors.lastname: Ma
authors.forename: Yi-Wu
authors.initials: YW
authors.lastname: Shi
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives*; D002681:China / Q000453:epidemiology / Q000208:ethnology; D003875:Drug Eruptions / Q000209:etiology*; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000078330:Oxcarbazepine
chemical_list: D000927:Anticonvulsants; D015235:HLA-B Antigens; D002220:Carbamazepine; D000078330:Oxcarbazepine