title: A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort.
abstract: A total of 569 individuals aged 55-85 and Caucasian were genotyped for SNP rs10927887 in the Ka renal chloride channel gene (CLCNKA). The following variables were significantly associated with an estimated glomerular filtration rate of (eGFR) <60 ml/min./1.73 m(2): age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype (p=0.03; OR=1.65, 95% CI=1.04-2.62). This novel finding could partly explain the reported greater risk of heart failure linked to the CLCNKA SNP, but requires confirmation on other populations.
authors.affiliation: Genética Molecular-Laboratorio Medicina, HUCA, Oviedo, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Tavira
authors.forename: Juan
authors.initials: J
authors.lastname: Gómez
authors.forename: Francisco
authors.initials: F
authors.lastname: Ortega
authors.forename: Salvador
authors.initials: S
authors.lastname: Tranche
authors.forename: Carmen
authors.initials: C
authors.lastname: Díaz-Corte
authors.forename: Francisco
authors.initials: F
authors.lastname: Alvarez
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz
authors.forename: Fernando
authors.initials: F
authors.lastname: Santos
authors.forename: María D
authors.initials: MD
authors.lastname: Sánchez-Niño
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018118:Chloride Channels / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000235:genetics*; D006333:Heart Failure / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C489932:CLCNKA protein, human; D018118:Chloride Channels
keywords: BMI; CKD; CLCNKA; Gene polymorphisms; Glomerular filtration; HSPB7; HTA; K(a) renal chloride channel gene; MDRD; Modification of Diet in Renal Disease; RFLP; Renal function; SNPs; T2DM; body mass index; chronic kidney disease; eGFR; estimated glomerular filtration rate; heat shock protein B7 gene; hypertension; restriction fragment length polymorphism; single nucleotide polymorphisms; type 2 diabetes mellitus