title: Expression levels of IL-27 and IL-17 in multiple myeloma patients: a higher ratio of IL-27:IL-17 in bone marrow was associated with a superior progression-free survival.
abstract: The goal of the study was to investigate the levels of interleukin-27 (IL-27) and IL-17 in bone marrow (BM) and peripheral blood (PB) of multiple myeloma (MM). The levels of IL-27 and IL-17 were determined in MM patients and controls using ELISA. The results showed a decreased IL-27 and elevated IL-17 level in MM patients and a negative association of IL-27 with IL-17. The ratio of IL-27:IL-17 in BM of newly diagnosed MM was significantly decreased and correlated with the progression of disease. Multivariate analysis showed that a higher ratio of IL-27:IL-17 in BM was associated with a superior progression-free survival (HR=0.160; 95% CI: 0.058-0.443; p<0.001). Our results suggest that there might be a possible competitive role of IL-27 and IL-17 in MM.
authors.affiliation: Department of Hematology, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Song
authors.forename: Jian-Zhu
authors.initials: JZ
authors.lastname: Yang
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Sun
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Meng
authors.forename: Jin-Qiao
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Lv
authors.forename: Ling-Juan
authors.initials: LJ
authors.lastname: Kong
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality*; D009367:Neoplasm Staging; D011379:Prognosis; D012074:Remission Induction; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D020381:Interleukin-17; D007378:Interleukins; C464565:MYDGF protein, human
keywords: Interleukin-17; Interleukin-27; Multiple myeloma; Progression-free survival