title: Analysis of the polymorphisms EGFR-r521K and ERBB2-I655V in Mexican patients with gastric cancer and premalignant gastric lesions.
abstract: The proto-oncogenes epidermal growth factor receptor (EGFR) and erythroblastic leukemia viral oncogene homolog 2 (ERBB2), are involved in the development of diverse malignant tumors, including gastric cancer. We analyzed the association of SNPs EGFR-R521K and ERBB2-I655V with gastric cancer and premalignant gastric lesions in Mexican patients. Through restriction fragment length polymorphisms, we analyze both SNPs in the DNA from 155 patients with gastric cancer and premalignant gastric lesions, 121 controls, and 103 people from the Mexican general population. The frequencies of both SNPs did not differ significantly between any of the groups (chi2 p = NS); Odds ratio analysis showed that the alleles EGFR-521K and ERBB2-655V were not related to gastric cancer or premalignant gastric lesions in the Mexican population. Our data suggest that the EGFR-R521K and ERBB2-I655V polymorphisms are not suitable as markers for identifying individuals with a higher risk for developing gastric cancer in our population.
authors.affiliation: Genética Humana CUCS, Universidad de Guadalajara.
authors.forename: Juan Heriberto
authors.initials: JH
authors.lastname: Torres-Jasso
authors.forename: Andrea Rebeca
authors.initials: AR
authors.lastname: Bustos-Carpinteyro
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Marín
authors.forename: Ernesto
authors.initials: E
authors.lastname: Santiago
authors.forename: Carlos
authors.initials: C
authors.lastname: Leoner
authors.forename: Lourdes
authors.initials: L
authors.lastname: Flores-Luna
authors.forename: Javier
authors.initials: J
authors.lastname: Torres
authors.forename: Josefina Yoaly
authors.initials: JY
authors.lastname: Sánchez-Lopez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D018734:Genes, erbB-2 / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011230:Precancerous Conditions / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*; D055815:Young Adult
chemical_list: D066246:ErbB Receptors