title: Changes in NAD content induced by nicotinic acid-related compounds in K562 cells during differentiation.
abstract: Two nicotinic acid-related compounds were found to induce erythroid differentiation in K562 cells. We investigated the changes in nicotinamide adenine dinucleotide (NAD) content induced by nicotinic acid-related compounds during differentiation. The NAD content was reduced by a treatment with nicotinic acid and isonicotinic acid. These results provide important clues toward elucidating the erythroid differentiation mechanism.
authors.affiliation: Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Shiga 526-0829, Japan.
authors.forename: Chieri
authors.initials: C
authors.lastname: Ida
authors.forename: Shin
authors.initials: S
authors.lastname: Ogata
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects*; D006801:Humans; D020014:K562 Cells; D009243:NAD / Q000378:metabolism*; D009525:Niacin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D009243:NAD; D009525:Niacin