title: Go-rei-San, a Kampo medicine, reduces postoperative nausea and vomiting: a prospective, single-blind, randomized trial.
abstract: OBJECTIVE
  The objective of this study was to determine the efficacy of Go-rei-San (GRS), a Kampo medicine, in the treatment of postoperative nausea, vomiting, or both nausea and vomiting (PONV).
  
  
  METHODS
  The study was a randomized, controlled, single-blind study of two groups of adult female patients who were scheduled to undergo benign gynecological laparoscopic surgery under general anesthesia. Patients in each group possessed an American Society of Anesthesiologists physical status of 1 (normal, healthy patient) to 2 (patient with a mild systemic disease). Patients were randomly assigned to the GRS group or the no-intervention group.
  
  
  METHODS
  Patients in the GRS group were given 7.5 g of GRS orally the day before surgery.
  
  
  METHODS
  The primary outcome measure was the severity of nausea at 0-3 h and 0-24 h after tracheal extubation. The secondary outcome measures were the incidence of vomiting at 0-3 h and 0-24 h and the frequency of vomiting at 0-24 h. The severity of nausea was measured by the patient, who used an 11-point verbal scale to indicate her strongest nausea.
  
  
  RESULTS
  Of the 100 female patients selected for the study, 99 completed the trial, and no adverse events occurred. The severity of nausea, frequency of vomiting, and incidence of vomiting were significantly lower in the GRS group than in the no-intervention group.
  
  
  CONCLUSIONS
  This study suggests that GRS may be effective for the reduction of PONV.
authors.affiliation: 1 Department of Anesthesiology, Osaka Medical College , Takatsuki, Osaka, Japan .
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kori
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Oikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Odaguchi
authors.forename: Haruka
authors.initials: H
authors.lastname: Omoto
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Hanawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Minami
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects / Q000379:methods; D006801:Humans; D020835:Medicine, Kampo; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy* / Q000517:prevention & control*; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; C111129:gorei-san