title: Slowing down DNA translocation through solid-state nanopores by pressure.
abstract: The effect of applied pressure on event duration distributions in 3 kb dsDNA translocation is systematically investigated. The effects of pressure magnitude and nanopore size on the length discrimination between 615 bp and 1.14 kbp dsDNA is studied. The pressure-controlled DNA translocation in solid-state nanopores makes a significant contribution to improve the temporal resolution in DNA single-molecule detection.
authors.affiliation: State Key Laboratory for Mesoscopic Physics and Electron Microscopy Laboratory, School of Physics, Peking University, Beijing 100871, PR China.
authors.forename: Hengbin
authors.initials: H
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Tang
authors.forename: Song
authors.initials: S
authors.lastname: Liu
authors.forename: Qingtao
authors.initials: Q
authors.lastname: Li
authors.forename: Zhongchao
authors.initials: Z
authors.lastname: Fan
authors.forename: Fuhua
authors.initials: F
authors.lastname: Yang
authors.forename: Liping
authors.initials: L
authors.lastname: You
authors.forename: Xuemei
authors.initials: X
authors.lastname: Li
authors.forename: Jingmin
authors.initials: J
authors.lastname: Zhang
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yu
mesh_terms: D000465:Algorithms; D017360:Arabidopsis / Q000235:genetics; D004247:DNA / Q000032:analysis* / Q000737:chemistry; D004926:Escherichia coli / Q000235:genetics; D006863:Hydrogen-Ion Concentration; D008962:Models, Theoretical; D056004:Molecular Dynamics Simulation; D058608:Nanopores; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D016012:Poisson Distribution; D011312:Pressure
chemical_list: D004247:DNA
keywords: DNA translocation; pressure gradients; short molecule selectivity; solid-state nanopores