title: Integrating pathways of Parkinson's disease in a molecular interaction map.
abstract: Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused by a complex interplay of genetic and environmental factors. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. Here we introduce a computationally tractable, comprehensive molecular interaction map of PD. This map integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation. We also present bioinformatics tools for the analysis, enrichment and annotation of the map, allowing the research community to open new avenues in PD research. The PD map is accessible at http://minerva.uni.lu/pd_map .
authors.affiliation: The Systems Biology Institute, Minato-ku, Tokyo, Japan.
authors.forename: Kazuhiro A
authors.initials: KA
authors.lastname: Fujita
authors.forename: Marek
authors.initials: M
authors.lastname: Ostaszewski
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Samik
authors.initials: S
authors.lastname: Ghosh
authors.forename: Enrico
authors.initials: E
authors.lastname: Glaab
authors.forename: Christophe
authors.initials: C
authors.lastname: Trefois
authors.forename: Isaac
authors.initials: I
authors.lastname: Crespo
authors.forename: Thanneer M
authors.initials: TM
authors.lastname: Perumal
authors.forename: Wiktor
authors.initials: W
authors.lastname: Jurkowski
authors.forename: Paul M A
authors.initials: PM
authors.lastname: Antony
authors.forename: Nico
authors.initials: N
authors.lastname: Diederich
authors.forename: Manuel
authors.initials: M
authors.lastname: Buttini
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kodama
authors.forename: Venkata P
authors.initials: VP
authors.lastname: Satagopam
authors.forename: Serge
authors.initials: S
authors.lastname: Eifes
authors.forename: Antonio
authors.initials: A
authors.lastname: Del Sol
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schneider
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kitano
authors.forename: Rudi
authors.initials: R
authors.lastname: Balling
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D006801:Humans; D008636:Mesencephalon / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009415:Nerve Net / Q000378:metabolism* / Q000473:pathology; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D059748:Proteolysis; D015398:Signal Transduction / Q000502:physiology*