title: -Oh no! hiPSCs misplace their 5hmCs.
abstract: hiPSCs and hESCs are thought to display subtle genetic and epigenetic variability. Recently in Nature Cell Biology, Wang et al. (2013) demonstrated a role for TET1 during reprogramming of human cells and showed that hiPSCs lack appropriate 5hmC marks in subtelomeric regions, contributing to epigenetic variation common to hiPSCs.
authors.affiliation: Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA. blowry@ucla.edu
authors.forename: William E
authors.initials: WE
authors.lastname: Lowry
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism*; D003596:Cytosine / Q000031:analogs & derivatives*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D044503:5-Methylcytosine; D003596:Cytosine