title: Quality of life in sarcopenia and frailty.
abstract: The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate.
authors.affiliation: Service of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. rene.rizzoli@unige.ch
authors.forename: René
authors.initials: R
authors.lastname: Rizzoli
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Reginster
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Arnal
authors.forename: Ivan
authors.initials: I
authors.lastname: Bautmans
authors.forename: Charlotte
authors.initials: C
authors.lastname: Beaudart
authors.forename: Heike
authors.initials: H
authors.lastname: Bischoff-Ferrari
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Biver
authors.forename: Steven
authors.initials: S
authors.lastname: Boonen
authors.forename: Maria-Luisa
authors.initials: ML
authors.lastname: Brandi
authors.forename: Arkadi
authors.initials: A
authors.lastname: Chines
authors.forename: Cyrus
authors.initials: C
authors.lastname: Cooper
authors.forename: Sol
authors.initials: S
authors.lastname: Epstein
authors.forename: Roger A
authors.initials: RA
authors.lastname: Fielding
authors.forename: Bret
authors.initials: B
authors.lastname: Goodpaster
authors.forename: John A
authors.initials: JA
authors.lastname: Kanis
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Kaufman
authors.forename: Andrea
authors.initials: A
authors.lastname: Laslop
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Malafarina
authors.forename: Leocadio Rodriguez
authors.initials: LR
authors.lastname: Mañas
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Mitlak
authors.forename: Richard O
authors.initials: RO
authors.lastname: Oreffo
authors.forename: Jean
authors.initials: J
authors.lastname: Petermans
authors.forename: Kieran
authors.initials: K
authors.lastname: Reid
authors.forename: Yves
authors.initials: Y
authors.lastname: Rolland
authors.forename: Avan Aihie
authors.initials: AA
authors.lastname: Sayer
authors.forename: Yannis
authors.initials: Y
authors.lastname: Tsouderos
authors.forename: Marjolein
authors.initials: M
authors.lastname: Visser
authors.forename: Olivier
authors.initials: O
authors.lastname: Bruyère
mesh_terms: D000368:Aged; D000375:Aging; D002100:Cachexia / Q000150:complications; D015897:Comorbidity; D016330:Frail Elderly; D006801:Humans; D009765:Obesity / Q000150:complications; D011788:Quality of Life; D055948:Sarcopenia / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology* / Q000628:therapy; D011795:Surveys and Questionnaires