title: FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.
abstract: Multiple lines of evidence suggest that fatty acids (FA) play an important role in cognitive function. However, little is known about the functional genetic pathways involved in cognition. The main goals of this study were to replicate previously reported interaction effects between breast feeding (BF) and FA desaturase (FADS) genetic variation on IQ and to investigate the possible mechanisms by which these variants might moderate BF effect, focusing on brain expression. Using a sample of 534 twins, we observed a trend in the moderation of BF effects on IQ by FADS2 variation. In addition, we made use of publicly available gene expression databases from both humans (193) and mice (93) and showed that FADS2 variants also correlate with FADS1 brain expression (P-value<1.1E-03). Our results provide novel clues for the understanding of the genetic mechanisms regulating FA brain expression and improve the current knowledge of the FADS moderation effect on cognition.
authors.affiliation: Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands ; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Amsterdam, The Netherlands.
authors.forename: Thais S
authors.initials: TS
authors.lastname: Rizzi
authors.forename: Sophie
authors.initials: S
authors.lastname: van der Sluis
authors.forename: Catherine
authors.initials: C
authors.lastname: Derom
authors.forename: Evert
authors.initials: E
authors.lastname: Thiery
authors.forename: Ronald E
authors.initials: RE
authors.lastname: van Kesteren
authors.forename: Nele
authors.initials: N
authors.lastname: Jacobs
authors.forename: Sofie
authors.initials: S
authors.lastname: Van Gestel
authors.forename: Robert
authors.initials: R
authors.lastname: Vlietinck
authors.forename: Matthijs
authors.initials: M
authors.lastname: Verhage
authors.forename: Peter
authors.initials: P
authors.lastname: Heutink
authors.forename: Danielle
authors.initials: D
authors.lastname: Posthuma
mesh_terms: D000368:Aged; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002648:Child; D030541:Databases, Genetic; D000090943:Delta-5 Fatty Acid Desaturase; D004032:Diet; D044943:Fatty Acid Desaturases / Q000235:genetics* / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D014644:Genetic Variation; D006801:Humans; D007360:Intelligence / Q000235:genetics / Q000502:physiology; D008297:Male; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D005227:Fatty Acids; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human; C000623295:FADS1 protein, mouse; C533241:FADS2 protein, human; C000623294:FADS2 protein, mouse