title: Antimicrobial, antiparasitic, anti-inflammatory, and cytotoxic activities of Lopezia racemosa.
abstract: The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts and fractions were tested against a panel of nine bacterial and four fungal species. The antiparasitic activity was tested against Leishmania donovani, whereas the anti-inflammatory activity of the compounds was determined by measuring the secretion of interleukin-6 from human-derived macrophages. The same macrophage cell line was used to investigate the cytotoxicity of the compounds. Various extracts and fractions showed antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. The hexanic fraction HF 11-14b was the most interesting fraction with antimicrobial, and anti-inflammatory activities. The benefit of L. racemosa as a traditional medicinal plant was confirmed as shown by its antibacterial, antifungal and anti-inflammatory activities. To the best of our knowledge, this is the first study reporting the biological activities of L. racemosa, including antiparasitic and anti-inflammatory activities.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of British Columbia, 410-2660 Oak Street, Vancouver, BC, Canada V6H 3Z5.
authors.forename: Carla
authors.initials: C
authors.lastname: Cruz Paredes
authors.forename: Paulina
authors.initials: P
authors.lastname: Bolívar Balbás
authors.forename: Anaximandro
authors.initials: A
authors.lastname: Gómez-Velasco
authors.forename: Zaida Nelly
authors.initials: ZN
authors.lastname: Juárez
authors.forename: Eugenio
authors.initials: E
authors.lastname: Sánchez Arreola
authors.forename: Luis Ricardo
authors.initials: LR
authors.lastname: Hernández
authors.forename: Horacio
authors.initials: H
authors.lastname: Bach
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000977:Antiparasitic Agents / Q000494:pharmacology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003603:Cytotoxins / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology; D007893:Leishmania donovani / Q000187:drug effects*; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D029594:Onagraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D013534:Survival
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000977:Antiparasitic Agents; D003603:Cytotoxins; D015850:Interleukin-6; D010936:Plant Extracts