title: Artificial Neural Networks, and Evolutionary Algorithms as a systems biology approach to a data-base on fetal growth restriction.
abstract: One of the specific aims of systems biology is to model and discover properties of cells, tissues and organisms functioning. A systems biology approach was undertaken to investigate possibly the entire system of intra-uterine growth we had available, to assess the variables of interest, discriminate those which were effectively related with appropriate or restricted intrauterine growth, and achieve an understanding of the systems in these two conditions. The Artificial Adaptive Systems, which include Artificial Neural Networks and Evolutionary Algorithms lead us to the first analyses. These analyses identified the importance of the biochemical variables IL-6, IGF-II and IGFBP-2 protein concentrations in placental lysates, and offered a new insight into placental markers of fetal growth within the IGF and cytokine systems, confirmed they had relationships and offered a critical assessment of studies previously performed.
authors.affiliation: Department of Pediatrics, University Hospital of Parma, Via Gramsci, 14-43126 Parma, Italy. Electronic address: mariaelisabeth.street@unipr.it.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Street
authors.forename: Massimo
authors.initials: M
authors.lastname: Buscema
authors.forename: Arianna
authors.initials: A
authors.lastname: Smerieri
authors.forename: Luisa
authors.initials: L
authors.lastname: Montanini
authors.forename: Enzo
authors.initials: E
authors.lastname: Grossi
mesh_terms: D000465:Algorithms; D000818:Animals; D016208:Databases, Factual; D019143:Evolution, Molecular; D005317:Fetal Growth Retardation; D006801:Humans; D016571:Neural Networks, Computer; D049490:Systems Biology / Q000379:methods*
keywords: ANNS; Artificial Neural Networks; EA; Evolutionary Algorithms; Fetal growth; IGF; IGFBP; IGFBP-2; IL-6; IUGR; Systems biology; insulin-like growth factor; insulin-like growth factor binding protein; interleukin-6; intra-uterine growth restriction