title: Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs.
abstract: Circadian (24 h) clocks provide a source of internal timing in most living organisms. These clocks keep time by using complex transcriptional/post-translational feedback loops that are strikingly resilient to changes in environmental conditions. In the last few years, interest has increased in the role of post-transcriptional regulation of circadian clock components. Post-transcriptional control plays a prominent role in modulating rapid responses of the circadian system to environmental changes, including light, temperature and general stress and will be the focus of this review.
authors.affiliation: Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat-Ram, 91904 Jerusalem, Israel.
authors.forename: Osnat
authors.initials: O
authors.lastname: Bartok
authors.forename: Charalambos P
authors.initials: CP
authors.lastname: Kyriacou
authors.forename: Joel
authors.initials: J
authors.lastname: Levine
authors.forename: Amita
authors.initials: A
authors.lastname: Sehgal
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kadener
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D057906:Circadian Clocks / Q000235:genetics* / Q000502:physiology; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009491:Neurospora / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D035683:MicroRNAs
keywords: circadian clock; environment; post-transcriptional regulation