title: Peritoneal carcinomatosis of gastric origin: a population-based study on incidence, survival and risk factors.
abstract: Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. The aim of the current study was to provide reliable population-based data on the incidence, risk factors and prognosis of PC of gastric origin. All patients diagnosed with gastric cancer in the area of the Eindhoven Cancer Registry between 1995 and 2011 were included. Incidence and survival were computed and risk factors for peritoneal carcinomatosis were determined using multivariate logistic regression analysis. In total, 5,220 patients were diagnosed with gastric cancer, of whom 2,029 (39%) presented with metastatic disease. PC was present in 706 patients (14%) of whom 491 patients (9%) had PC as the only metastatic site. Younger age (<60 years), female gender, advanced T- and N-stage, primary tumor of signet ring cells or linitis plastica and primary tumors covering multiple anatomical locations of the stomach were all associated with a higher odds ratios of developing PC. Median survival of patients without metastases was 14 months, but only 4 months for patients with PC. PC is a frequent condition in patients presenting with gastric cancer, especially in younger patients with advanced tumor stages. Given the detrimental influence of PC on survival, efforts should be undertaken to further explore the promising results that were obtained in preventing or treating this condition with multimodality strategies.
authors.affiliation: Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands; Eindhoven Cancer Registry, Comprehensive Cancer Centre South (IKZ), Eindhoven, The Netherlands.
authors.forename: Irene
authors.initials: I
authors.lastname: Thomassen
authors.forename: Yvette R
authors.initials: YR
authors.lastname: van Gestel
authors.forename: Bert
authors.initials: B
authors.lastname: van Ramshorst
authors.forename: Misha D
authors.initials: MD
authors.lastname: Luyer
authors.forename: Koop
authors.initials: K
authors.lastname: Bosscha
authors.forename: Simon W
authors.initials: SW
authors.lastname: Nienhuijs
authors.forename: Valery E
authors.initials: VE
authors.lastname: Lemmens
authors.forename: Ignace H
authors.initials: IH
authors.lastname: de Hingh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D010534:Peritoneal Neoplasms / Q000453:epidemiology / Q000556:secondary*; D011159:Population Surveillance; D012042:Registries; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology*; D015996:Survival Rate
keywords: gastric cancer; incidence; metastasis; peritoneal carcinomatosis; prognosis; treatment