title: Chiroptical properties of anionic and cationic porphyrins and metalloporphyrins in complex with left-handed Z-DNA and right-handed B-DNA.
abstract: We report the chiroptical signature and binding interactions of cationic (meso-tetrakis(4-N-methylptridyl)porphyrin, 2HT4) and anionic (meso-tetrakis(4-sulfonatophenyl)porphyrin, 2HTPPS) porphyrins and their zinc(II) and nickel(II) derivatives (ZnT4, ZnTPPS, NiT4, and NiTPPS) with right-handed B-form and two forms of left-handed Z-form of alternating guanine-cytosine polydeoxynucleotide poly(dG-dC)2. NiTPPS is able to spectroscopically discriminate between spermine-induced Z-DNA and Co(III)-induced Z-DNA via new induced circular dichroism signal in the visible region of the electromagnetic spectrum.
authors.affiliation: University of Wyoming, Department of Chemistry, Laramie, WY 82071, USA.
authors.forename: Jung Kyu
authors.initials: JK
authors.lastname: Choi
authors.forename: Alessandro
authors.initials: A
authors.lastname: D'Urso
authors.forename: Milan
authors.initials: M
authors.lastname: Balaz
mesh_terms: D000838:Anions; D002412:Cations; D002942:Circular Dichroism; D059371:DNA, B-Form / Q000737:chemistry*; D043542:DNA, Z-Form / Q000737:chemistry*; D008665:Metalloporphyrins / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D011089:Polydeoxyribonucleotides / Q000737:chemistry; D013096:Spermine / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D000838:Anions; D002412:Cations; D059371:DNA, B-Form; D043542:DNA, Z-Form; D008665:Metalloporphyrins; D011089:Polydeoxyribonucleotides; C019530:poly(dC-dG); D013096:Spermine; D009532:Nickel; D015032:Zinc
keywords: Charged metalloporphyrin; DNA binding; Induced circular dichroism; Left-handed Z-DNA; Spermine; hexamminecobalt(III) chloride