title: Oropharyngeal cancer related to Human Papilloma Virus: incidence and prognosis in Madrid, Spain.
abstract: OBJECTIVE
  To report the incidence of HPV-related oropharyngeal cancer (OC) in our region, and determine the influence of HPV status on survival among patients treated with chemoradiation (CRT).
  
  
  METHODS
  A total of 102 patients with stage II-IV OC treated by CRT at four hospitals in Madrid, Spain were retrospectively reviewed. Immunohistochemistry analysis was performed to evaluate p16 expression in pretreatment tumor block samples obtained from these patients. HPV-positive and HPV-negative patients were compared to assess differences in overall survival (OS), loco-regional control and disease-free survival.
  
  
  RESULTS
  Of the tumor samples evaluated, 26.7 % were p16 positive. HPV-positive patients were younger (median age, 56 vs 59 years; p = 0.052). No significant differences were observed in terms of tumor stage, gender, or smoking habit between HPV+ and HPV- patients. HPV+ patients showed a trend towards better OS (67.4, vs 49.7 %; hazard ratio, 0.55; p = 0.095).
  
  
  CONCLUSIONS
  Incidence of HPV-related OC in our region is similar to that reported in other regions in Europe, yet lower than in North America. We observed a trend for improved OS in patients with HPV+ oropharyngeal cancer.
authors.affiliation: Instituto de Investigación del Hospital de la Princesa, Madrid, Spain, lcerezo.hlpr@salud.madrid.org.
authors.forename: L
authors.initials: L
authors.lastname: Cerezo
authors.forename: A
authors.initials: A
authors.lastname: de la Torre
authors.forename: A
authors.initials: A
authors.lastname: Hervás
authors.forename: A
authors.initials: A
authors.lastname: Ruiz
authors.forename: O
authors.initials: O
authors.lastname: Liñán
authors.forename: M
authors.initials: M
authors.lastname: López
authors.forename: K
authors.initials: K
authors.lastname: Villar
authors.forename: M
authors.initials: M
authors.lastname: Martín
mesh_terms: D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D042282:Microdissection; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology*; D011379:Prognosis; D016016:Proportional Hazards Models; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013030:Spain / Q000453:epidemiology