title: Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature.
abstract: Chromosomal translocations involving the immunoglobulin heavy chain locus (IGH@) are recurrent but rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and various partner genes have been described. Here, we report a new series of 29 cases of BCP-ALL with IGH@ translocations. The partner gene was identified by fluorescence in situ hybridization and/or molecular cloning in 20 patients. Members of the CEBP gene family (n = 11), BCL2 (n = 3), ID4 (n = 3), EPOR (n = 2), and TRA/D@ (n = 1) were identified and demonstrated by quantitative real-time reverse transcriptase-polymerase chain reaction to be markedly up-regulated. The present cases, added to those already reported, confirm the diversity of the partner genes, which, apart from BCL2, are specific to BCP-ALL. Collectively, patients with IGH@ translocations may represent a novel sub-group of BCP-ALL occurring in adolescents and young adults.
authors.affiliation: Department of Hematology, Pitie-Salpetriere Hospital, Assistance Publique-Hôpitaux de Paris, University Pierre et Marie Curie, Paris 6, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Chapiro
authors.forename: Isabelle
authors.initials: I
authors.lastname: Radford-Weiss
authors.forename: Hong-Anh
authors.initials: HA
authors.lastname: Cung
authors.forename: Nicole
authors.initials: N
authors.lastname: Dastugue
authors.forename: Nathalie
authors.initials: N
authors.lastname: Nadal
authors.forename: Sylvie
authors.initials: S
authors.lastname: Taviaux
authors.forename: Carole
authors.initials: C
authors.lastname: Barin
authors.forename: Stephanie
authors.initials: S
authors.lastname: Struski
authors.forename: Pascaline
authors.initials: P
authors.lastname: Talmant
authors.forename: Peter
authors.initials: P
authors.lastname: Vandenberghe
authors.forename: Marie-Joelle
authors.initials: MJ
authors.lastname: Mozziconacci
authors.forename: Isabelle
authors.initials: I
authors.lastname: Tigaud
authors.forename: Christine
authors.initials: C
authors.lastname: Lefebvre
authors.forename: Dominique
authors.initials: D
authors.lastname: Penther
authors.forename: Christian
authors.initials: C
authors.lastname: Bastard
authors.forename: Eric
authors.initials: E
authors.lastname: Lippert
authors.forename: Francine
authors.initials: F
authors.lastname: Mugneret
authors.forename: Serge
authors.initials: S
authors.lastname: Romana
authors.forename: Olivier A
authors.initials: OA
authors.lastname: Bernard
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Harrison
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Russell
authors.forename: Florence
authors.initials: F
authors.lastname: Nguyen-Khac
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002883:Chromosomes, Human, Pair 14; D003001:Cloning, Molecular; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D051796:Inhibitor of Differentiation Proteins / Q000235:genetics; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D017467:Receptors, Erythropoietin / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C490128:ID4 protein, human; D007143:Immunoglobulin Heavy Chains; D051796:Inhibitor of Differentiation Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D017467:Receptors, Erythropoietin
keywords: B-cell progenitor acute lymphoblastic leukemia; IGH@ translocations