title: Andirolides Q-V from the flower of andiroba (Carapa guianensis, Meliaceae).
abstract: Two new gedunins, an andirobin, two mexicanolides, and a phragmalin-type limonoid, named Andirolides Q (1), R (2), S (3), T (4), U (5), and V (6), were isolated from an oil of the flower of Carapa guianensis AUBLET (Meliaceae). Their structures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR spectra and FABMS. Andirolide S (3) and Andirolide T (4) showed significant cytotoxic activity against the murine P388 leukemia cell line (IC₅₀ of 1.4 μM for 3; 1.8 μM for 4) and the human HL-60 leukemia cell line (IC₅₀ of 1.3 μM for 3 and 4).
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
authors.forename: Asami
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Takanobu
authors.initials: T
authors.lastname: Inoue
authors.forename: Takashi
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kajimoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Muraoka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D035264:Flowers / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010938:Plant Oils / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins; D010938:Plant Oils
keywords: Andirolides Q–V; Carapa guianensis; Human HL-60 leukemia cell line; Limonoid; Murine P388 leukemia cell line