title: Autoimmune lymphoproliferative syndrome and non-Hodgkin lymphoma: what 18F-fluorodeoxyglucose positron emission tomography/computed tomography can do in the management of these patients? Suggestions from a case report.
abstract: A young patient with undefined autoimmune lymphoproliferative syndrome (ALPS-U) and low back pain underwent a CT and MRI study that showed enhancing vertebral lesions, some pulmonary nodules and diffuse latero-cervical lymphadenopathy. A (18)F-FDG-PET/CT scan showed many areas of intense (18)F-FDG uptake in multiple vertebrae, in some ribs, in the sacrum, in the liver, in both lungs, in multiple lymph nodes spread in the cervical, thoracic and abdominal chains. A bone marrow biopsy showed a "lymphomatoid granulomatosis", a rare variant of B-cell non-Hodgkin lymphoma (NHL). After the treatment, the (18)F-FDG-PET/CT scan showed a complete metabolic response.
authors.affiliation: Positron Emission Tomography Centre, IRMET S.p.A., Euromedic Inc., Turin, Italy. Electronic address: a.cistaro@irmet.com.
authors.forename: A
authors.initials: A
authors.lastname: Cistaro
authors.affiliation: Department of Radiology, San Luigi Gonzaga Hospital, Turin, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pazè
authors.affiliation: Department of Radiology, San Luigi Gonzaga Hospital, Turin, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Durando
authors.affiliation: Department of Neuroradiology, CTO Hospital, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cogoni
authors.affiliation: Department of Radiology, San Giovanni Battista Hospital, Turin, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Faletti
authors.affiliation: Department of Physical Medicine and Rehabilitation, Martini Hospital, Turin, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Vesco
authors.affiliation: Pediatric Department, University of Turin, Turin, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Vallero
authors.affiliation: Department of Radiological Sciences, Nuclear Medicine Unit, University of Messina, Messina, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Quartuccio
authors.affiliation: Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Treglia
authors.affiliation: Pediatric Department, University of Turin, Turin, Italy.
authors.forename: U
authors.initials: U
authors.lastname: Ramenghi
mesh_terms: D000328:Adult; D056735:Autoimmune Lymphoproliferative Syndrome / Q000175:diagnosis* / Q000628:therapy*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Autoimmune lymphoproliferative syndrome; Fas gene; Gen Fas; Linfoma no Hodgkin; Non-Hodgkin lymphoma; PET; Rituximab; Síndrome linfoproliferativo autoinmune