title: Genetic control of quiescence in hematopoietic stem cells.
abstract: Cellular quiescence is a reversible cell cycle arrest that is poised to re-enter the cell cycle in response to a combination of cell-intrinsic factors and environmental cues. In hematopoietic stem cells, a coordinated balance between quiescence and differentiating proliferation ensures longevity and prevents both genetic damage and stem cell exhaustion. However, little is known about how all these processes are integrated at the molecular level. We will briefly review the environmental and intrinsic control of stem cell quiescence and discuss a new model that involves a protein-to-protein interaction between G0S2 and the phospho-nucleoprotein nucleolin in the cytosol.
authors.affiliation: Department of Pathology & Immunology; Baylor College of Medicine; Texas Children's Hospital; Houston, TX USA.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Chun Shik
authors.initials: CS
authors.lastname: Park
authors.forename: H Daniel
authors.initials: HD
authors.lastname: Lacorazza
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D059447:Cell Cycle Checkpoints / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000502:physiology; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000378:metabolism; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D016601:RNA-Binding Proteins / Q000378:metabolism; D000097796:Nucleolin
chemical_list: D018797:Cell Cycle Proteins; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D000097796:Nucleolin; C508073:G0S2 protein, human
keywords: G0S2; hematopoietic stem cells; quiescence