title: Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose.
abstract: We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.
  
  
  
  An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.
  
  
  
  These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).
  
  
  
  The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD.
authors.affiliation: Departments of Radiology and Psychiatry, Saint Joseph's Hospital and Medical Center/The Barrow Neurologic Institute, Phoenix, Arizona, United States of America ; Department of Radiology, Creighton University School of Medicine, Omaha, Nebraska, United States of America.
authors.forename: Frank
authors.initials: F
authors.lastname: Schraml
authors.forename: Kewei
authors.initials: K
authors.lastname: Chen
authors.forename: Napatkamon
authors.initials: N
authors.lastname: Ayutyanont
authors.forename: Roontiva
authors.initials: R
authors.lastname: Auttawut
authors.forename: Jessica B S
authors.initials: JB
authors.lastname: Langbaum
authors.forename: Wendy
authors.initials: W
authors.lastname: Lee
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Liu
authors.forename: Dan
authors.initials: D
authors.lastname: Bandy
authors.forename: Stephanie Q
authors.initials: SQ
authors.lastname: Reeder
authors.forename: Gene E
authors.initials: GE
authors.lastname: Alexander
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Caselli
authors.forename: Adam S
authors.initials: AS
authors.lastname: Fleisher
authors.forename: Eric M
authors.initials: EM
authors.lastname: Reiman
mesh_terms: D017668:Age of Onset; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D018628:Gene Dosage; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography
chemical_list: D053327:Apolipoprotein E4