title: [The expression and significance of apoptosis related gene BAG-1 in meningioma].
abstract: OBJECTIVE
  To analyze the expressions of BAG-1 in meningioma for further understanding of biological behaviors of meningiomas.
  
  
  METHODS
  The specimens included in this study were collected from 158 meningioma cases. Streptavidin-peroxidase were used in immunohistochemical staining. The results of immunohistochemical score were depending on the positive ratio and intensity of the immunoreactivity. The expressions of BAG-1 in meningioma were analyzed in relationship with histopathologic grading, postoperative recurrence.
  
  
  RESULTS
  The difference in the expression degree of BAG-1 between each subtype in the same histopathologic grade and various subtypes between the grade of II to III were not statically significant (P > 0.05). The expression degree of BAG-1 between each subtype in the pathological grade I to the each subtype pathological grade I or III was different, the difference had statistical significance (P < 0.05 or P < 0.01). The immunohistochemical score of the expression of BAG-1 was decreased gradually with the pathologic grading of WHO increased, and the result was statistically significant (chi2 = 141.49, P < 0.01). As the immunohistochemical score of the expression of BAG-1 decreased the postoperative meningioma was easy to recur, the result was statistically significant (x2 = 55.13, P < 0.01).
  
  
  CONCLUSIONS
  The expression degree of BAG-1 is in close correlations with the WHO pathologic grading of meningioma. The lower the expressions of BAG-1, the more recurrent with postoperation of meningiomas will be.
authors.affiliation: Department of Neurosurgery, Taizhou Municipal Hospital, Taizhou Medical College, the Branch of Huashan Hospital, Fudan University, Taizhou 318000, China. kerry2000year@163.com
authors.forename: Kai-Yu
authors.initials: KY
authors.lastname: Zhou
authors.forename: Hang-Huang
authors.initials: HH
authors.lastname: Jin
authors.forename: Ting
authors.initials: T
authors.lastname: Zhou
authors.forename: Yong-Kang
authors.initials: YK
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017209:Apoptosis; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D014157:Transcription Factors / Q000378:metabolism*; D055815:Young Adult
chemical_list: C091732:BCL2-associated athanogene 1 protein; D004268:DNA-Binding Proteins; D014157:Transcription Factors