title: Dietary coenzyme Q10 suppressed hepatic hydroxymethylglutaryl-CoA reductase activity in laying hens.
abstract: The effects of dietary coenzyme Q10 (CoQ10) on cholesterol metabolism in laying hens were investigated. Dietary CoQ10 significantly reduced egg yolk cholesterol content and suppressed hepatic hydroxymethylglutaryl-CoA reductase (HMGR) activity. It is therefore likely that CoQ10 acts as an HMGR inhibitor in the livers of laying hens, which in turn results in a reduction in egg-yolk cholesterol.
authors.affiliation: Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe, Japan. honda@tiger.kobe-u.ac.jp
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Honda
authors.forename: Takaoki
authors.initials: T
authors.lastname: Saneyasu
authors.forename: Tohru
authors.initials: T
authors.lastname: Motoki
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Park
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kamisoyama
mesh_terms: D000818:Animals; D002645:Chickens / Q000502:physiology*; D002784:Cholesterol / Q000378:metabolism; D004032:Diet; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D010058:Oviposition / Q000187:drug effects*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014451:Ubiquinone; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; C024989:coenzyme Q10