title: Multiple samples improve the sensitivity for detection of mixed Mycobacterium infections.
abstract: By using VNTR genotyping, mixed infections of Mycobacterium tuberculosis were detected in 11.2% of cases in a prospective study in Heilongjiang China, a setting with a high prevalence (87.5%) of Beijing family strains. If only one sputum sample had been collected, the study would have underestimated the fraction of mixed infections by 50%.
authors.affiliation: Tuberculosis Control Center of Heilongjiang Province, No. 40, Youfang Street, Harbin, Heilongjiang 150030, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
authors.forename: Chongguang
authors.initials: C
authors.lastname: Yang
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Luo
authors.forename: Fabin
authors.initials: F
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015373:Bacterial Typing Techniques; D002681:China / Q000453:epidemiology; D005260:Female; D060005:Genotyping Techniques / Q000379:methods; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods; D013183:Sputum / Q000382:microbiology*; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology*; D055815:Young Adult
keywords: Drug resistance; Mixed infections; Multiple sampling; Mycobacterium tuberculosis