title: Sudden coronary death due to IgG4-related disease.
abstract: A 54-year-old male entered the emergency room in cardiorespiratory arrest after syncope at home. Resuscitation was attempted, but the patient died a few hours later. At necropsy, aneurysms were found at the right and left anterior descending coronary arteries. At microscopic examination, there was no significant coronary atherosclerosis, and a dense inflammatory infiltrate was detected, with a high number of igG4-positive cells (94.0 positive cells/hpf). The case illustrates that IgG4-related disease can cause coronary disease and sudden cardiac death.
authors.affiliation: Laboratory of Pathology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address: anppaulo@incor.usp.br.
authors.forename: Paulo Sampaio
authors.initials: PS
authors.lastname: Gutierrez
authors.forename: Thiago
authors.initials: T
authors.lastname: Schultz
authors.forename: Sheila Aparecida Coelho
authors.initials: SA
authors.lastname: Siqueira
authors.forename: Luciano
authors.initials: L
authors.lastname: de Figueiredo Borges
mesh_terms: D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D001344:Autopsy; D015415:Biomarkers / Q000097:blood; D016887:Cardiopulmonary Resuscitation; D003323:Coronary Aneurysm / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D003328:Coronary Thrombosis / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D017809:Fatal Outcome; D006323:Heart Arrest / Q000276:immunology / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G
keywords: Aneurysm; Coronary artery; IgG4-related disease; Necropsy; Sudden cardiac death