title: An overall assessment of circumanal gland adenoma in a terrier mix breed dog.
abstract: In September 2012, a 10-year-old, intact male, terrier mix breed dog was evaluated because of multiple, 0.5 to 1.2 cm in diameter, round, intradermal nodules around the anus. It had surgery to excise a firm, painful swelling in the left ventrolateral perianal region and the excision part was observed under light microscopy. The mass spreading in to sub acute was of left hind leg out from the ventro-lateral of anus, 1.2 cm×1 cm/ 0 cm×0.5 cm in size and 125 g in weight. A complete blood cell count, serum biochemistry panel, and urinalysis (cystocentesis sample) were evaluated. Significant laboratory data demonstrated microcytic anemia (hemoglobin of 6.4 mg/dL) and normal coagulation times. No remarkable abnormalities were found in the complete blood count and an ionized calcium of 1.91 mmol/L (reference range, 1.1-1.3 mmol/L) was confirmed hypercalcemia. On cytologic and histopathologic examinations, evaluation of the aspirate revealed a prominent population of round-to-polygonal nucleated cells arranged as cohesive groups with isolated individual cells. A mild degree of anisocytosis and anisokaryosis was observed. In addition, smaller reserve type cells, with darker cytoplasm and a higher nucleocytoplasmic ratio. The adenomas generally retain the lobular architecture, but some may contain focal areas of cellular pleomorphism. These changes may suggest malignant transformation and have led to discordant interpretations, the well-developed stroma surrounding the lobules and hepatoid cells was noted. Ulceration, hemorrhage, necrosis and secondary infection with inflammatory cell infiltrates are common. These cytology and histopathology features are consistent with hepatoid gland adenoma.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Javanbakht
authors.forename: Abbas
authors.initials: A
authors.lastname: Tavassoli
authors.forename: Farhang
authors.initials: F
authors.lastname: Sasani
authors.forename: Atefeh
authors.initials: A
authors.lastname: Sabbagh
authors.forename: Mehdi Aghamohamad
authors.initials: MA
authors.lastname: Hassan
authors.forename: Shohreh Alian
authors.initials: SA
authors.lastname: Samakkhah
authors.forename: Radmehr
authors.initials: R
authors.lastname: Shafiee
authors.forename: Meysam
authors.initials: M
authors.lastname: Jani
authors.forename: Samad
authors.initials: S
authors.lastname: Alimohammadi
authors.forename: Reza
authors.initials: R
authors.lastname: Samani
authors.forename: Fardin
authors.initials: F
authors.lastname: Barati
authors.forename: Vahideh Rahmani
authors.initials: VR
authors.lastname: Ghalee
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D000694:Anal Gland Neoplasms / Q000473:pathology / Q000601:surgery; D000818:Animals; D004283:Dog Diseases; D004285:Dogs; D008297:Male; D010481:Perianal Glands / Q000473:pathology*; D016896:Treatment Outcome
keywords: Blood cell count; Cytology; Dog; Hepatoid gland adenoma; Histopathology