title: Y90-radioembolization of lung metastases via the bronchial artery: a report of 2 cases.
abstract: We report successful Y90-radioembolization of the lung applying Y90-resin microspheres via the bronchial artery in two patients with diffuse colorectal and renal cancer metastases, respectively. The deposition of radioactive Y90-resin-microspheres was technically feasible and resulted in a reasonable absorbed dose in the tumors. However, open questions remain regarding dosimetry and safe dose exposure to the lung. The technique warrants thorough investigation before clinical use. A Phase I trial to evaluate safety and preliminary efficacy is under preparation.
authors.affiliation: Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg AöR, Leipzigerstrasse 44, 39120, Magdeburg, Germany. jens.ricke@med.ovgu.de.
authors.forename: Jens
authors.initials: J
authors.lastname: Ricke
authors.affiliation: Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg AöR, Leipzigerstrasse 44, 39120, Magdeburg, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Großer
authors.affiliation: Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg AöR, Leipzigerstrasse 44, 39120, Magdeburg, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Amthauer
mesh_terms: D000368:Aged; D001981:Bronchial Arteries; D015179:Colorectal Neoplasms / Q000473:pathology*; D004621:Embolization, Therapeutic / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D015021:Yttrium Radioisotopes