title: CMOS neurotransmitter microarray: 96-channel integrated potentiostat with on-die microsensors.
abstract: A 8 × 12 array of integrated potentiostats for on-CMOS neurotransmitter imaging is presented. Each potentiostat channel measures bidirectional redox currents proportional to the concentration of a neurochemical. By combining the current-to-frequency and the single-slope analog-to-digital converter (ADC) architectures a total linear dynamic range of 95 dB is achieved. A 3.8 mm × 3.1 mm prototype fabricated in a 0.35 μm standard CMOS technology was integrated with flat and 3D on-die gold microelectrodes and an on-chip microfluidic network. It is experimentally validated in in-situ recording of neurotransmitter dopamine.
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON M5S 3G4, Canada.
authors.forename: Meisam Honarvar
authors.initials: MH
authors.lastname: Nazari
authors.forename: Hamed
authors.initials: H
authors.lastname: Mazhab-Jafari
authors.forename: Lian
authors.initials: L
authors.lastname: Leng
authors.forename: Axel
authors.initials: A
authors.lastname: Guenther
authors.forename: Roman
authors.initials: R
authors.lastname: Genov
mesh_terms: D000200:Action Potentials; D015374:Biosensing Techniques; D001921:Brain / Q000378:metabolism; D002138:Calibration; D004298:Dopamine / Q000737:chemistry; D004563:Electrochemistry; D004867:Equipment Design; D006046:Gold / Q000737:chemistry; D006801:Humans; D046228:Microarray Analysis; D008839:Microelectrodes; D046210:Microfluidic Analytical Techniques; D008904:Miniaturization; D018377:Neurotransmitter Agents / Q000737:chemistry*; D010084:Oxidation-Reduction; D011199:Potentiometry; D012666:Semiconductors; D059629:Signal-To-Noise Ratio
chemical_list: D018377:Neurotransmitter Agents; D006046:Gold; D004298:Dopamine