title: Fractional CO2 laser as an effective modality in treatment of striae alba in skin types III and IV.
abstract: BACKGROUND
  Rapid stretching of the skin over the weak connective tissue leads to development of striae distensae. Recently, researchers have shown special interest towards use of fractional photothermolysis in treatment of striae and several studies have shown its usefulness. Our aim was to assess the efficacy of Fractional CO2 laser in treatment of striae alba.
  
  
  METHODS
  A randomized clinical trial was carried out in female patients with striae alba. Ninety two striae were randomly selected and divided into two groups. Five sessions of laser resurfacing, were performed in Group 1, every 2-4 weeks. Group 2 was treated with 10% glycolic acid+0.05% tretinoin cream nightly during the study. Photographs were taken from the striae before and two weeks after the end of treatment. Mean surface area of striae compared between two groups. Patients' views regarding the degree of improvement were assessed via visual analogue scale (VAS).
  
  
  RESULTS
  Forty six striae in Group 1 underwent laser resurfacing and 46 matched striae in Group 2, were treated with topical cream. Mean difference of striae surface area, was significantly decreased after treatment in Group 1 (-37.1±15.6 cm(2)) in comparison with Group 2(-7.9±9 cm(2)) (P value >0.001). Mean VAS was significantly higher in Group 1 (3.05±0.74) compared to Group 2 (0.63±0.66) (P value >0.001).
  
  
  CONCLUSIONS
  Fractional photothermolysis via Fractional CO2 laser seems to be an effective method for treatment of striae alba.
authors.affiliation: Department of Dermatology, Isfahan University of Medical Sciences, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Farahnaz Fatemi
authors.initials: FF
authors.lastname: Naein
authors.forename: Mehrnaz
authors.initials: M
authors.lastname: Soghrati
keywords: Fractional photothermolysis; fractional CO2 laser; striae alba; striae distensae