title: Changes in satiety hormone concentrations and feed intake in rats in response to lactic acid bacteria.
abstract: A negative energy balance can be accomplished by reducing the caloric intake which results in an increased feeling of hunger. This physiological state is regulated by secretion of satiety hormones. The secretion of these hormones can be influenced by ingestion of e.g. fat. Fat, dairy beverage and synbiotic mixture have been found to have satiety-inducing effects in humans and rats. Thus, the aim of this study was to investigate the change of satiety hormone concentration in rats in response to feeding of fermented milks containing lactic acid bacteria. Two studies were conducted with Wistar rats randomly allocated into groups receiving Lactobacillus fermented (2 L. acidophilus, L. bulgaricus, L. salivarius and L. rhamnosus) milk. A single isocaloric oral dose with the test item or control was given to the rats. Blood samples were taken after dosing with the test product and the satiety hormones were measured. For the test groups, significant changes could be detected in PYY concentrations after 60 min, although some groups had a significant lower feed intake. In conclusion, some probiotic Lactobacillus strains may modify satiety hormones production. However, more studies are needed to evaluate their potential of prolonging satiety.
authors.affiliation: DuPont Nutrition and Health, Active Nutrition, Sokeritehtaantie 20, 02460 Kantvik, Finland. Electronic address: sofia.forssten@dupont.com.
authors.forename: Sofia D
authors.initials: SD
authors.lastname: Forssten
authors.forename: Marta Z
authors.initials: MZ
authors.lastname: Korczyńska
authors.forename: Renate M L
authors.initials: RM
authors.lastname: Zwijsen
authors.forename: Wouter H
authors.initials: WH
authors.lastname: Noordman
authors.forename: Mari
authors.initials: M
authors.lastname: Madetoja
authors.forename: Arthur C
authors.initials: AC
authors.lastname: Ouwehand
mesh_terms: D000818:Animals; D002149:Energy Intake; D005285:Fermentation; D006728:Hormones / Q000097:blood*; D007778:Lactobacillus; D008297:Male; D008892:Milk / Q000382:microbiology; D019936:Probiotics / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012527:Satiation / Q000502:physiology*; D012528:Satiety Response / Q000502:physiology*
chemical_list: D006728:Hormones
keywords: Feed intake; Fermented milk; Hormones; Lactobacillus; Rat; Satiety