title: Patient-centered decision making in the treatment of chronic rhinosinusitis.
abstract: OBJECTIVE
  To explore possible factors that might impact a patient's choice to pursue endoscopic sinus surgery (ESS) or continue with medical management for treatment of refractory chronic rhinosinusitis (CRS).
  
  
  METHODS
  Cross-sectional evaluation of a multicenter prospective cohort.
  
  
  METHODS
  Two hundred forty-two subjects with CRS were prospectively enrolled within four academic tertiary care centers across North America with ongoing symptoms despite prior medical treatment. Subjects either self-selected continued medical management (n = 62) or ESS (n = 180) for treatment of sinonasal symptoms. Differences in demographics, comorbid conditions, and clinical measures of disease severity between subject groups were compared. Validated metrics of social support, personality, risk aversion, and physician-patient relationships were compared using bivariate analyses, predicted probabilities, and receiver operating characteristic curves at the 0.05 alpha level.
  
  
  RESULTS
  No significant differences were found between treatment groups for any demographic characteristic, clinical cofactor, or measure of social support, personality, or the physician-patient relationship. Subjects electing to pursue sinus surgery did report significantly worse average quality-of-life (QOL) scores on the 22-item Sinonasal Outcome Test (SNOT-22; P < .001) compared to those electing continued medical therapy (54.6 ± 18.9 vs. 39.4 ± 17.7), regardless of surgical history or polyp status. SNOT-22 score significantly predicted treatment selection (odds ratio, 1.046; 95% confidence interval, 1.028-1.065; P < .001) and was found to accurately discriminate between subjects choosing endoscopic sinus surgery and those electing medical management 72% of the time.
  
  
  CONCLUSIONS
  Worse patient-reported disease severity, as measured by the SNOT-22, was significantly associated with the treatment choice for CRS. Strong consideration should be given for incorporating CRS-specific QOL measures into routine clinical practice.
  
  
  METHODS
  2b.
authors.affiliation: Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and Neck Surgery , Medical University of South Carolina, Charleston, South Carolina, U.S.A.
authors.forename: Zachary M
authors.initials: ZM
authors.lastname: Soler
authors.forename: Luke
authors.initials: L
authors.lastname: Rudmik
authors.forename: Peter H
authors.initials: PH
authors.lastname: Hwang
authors.forename: Jess C
authors.initials: JC
authors.lastname: Mace
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Schlosser
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Smith
mesh_terms: D002908:Chronic Disease; D015897:Comorbidity; D003657:Decision Making; D004724:Endoscopy; D006801:Humans; D016015:Logistic Models; D010817:Physician-Patient Relations; D011788:Quality of Life; D012372:ROC Curve; D012220:Rhinitis / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery*; D012720:Severity of Illness Index; D012852:Sinusitis / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery*; D012944:Social Support
keywords: Chronic disease; decision making; drug therapy; general surgery; sinusitis; therapeutics