title: Osteoclasts and CD8 T cells form a negative feedback loop that contributes to homeostasis of both the skeletal and immune systems.
abstract: There are a number of dynamic regulatory loops that maintain homeostasis of the immune and skeletal systems. In this review, we highlight a number of these regulatory interactions that contribute to maintaining homeostasis. In addition, we review data on a negative regulatory feedback loop between osteoclasts and CD8 T cells that contributes to homeostasis of both the skeletal and immune systems.
authors.affiliation: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Boulevond DRC 605, St. Louis, MO 63104, USA.
authors.forename: Zachary S
authors.initials: ZS
authors.lastname: Buchwald
authors.forename: Rajeev
authors.initials: R
authors.lastname: Aurora
mesh_terms: D001842:Bone and Bones / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D002450:Cell Communication; D025461:Feedback, Physiological; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology; D010010:Osteoclasts / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D053245:RANK Ligand / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction
chemical_list: C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D053245:RANK Ligand; C505688:TNFSF11 protein, human; D016753:Interleukin-10; D007371:Interferon-gamma