title: Developmental toxicity of diesel exhaust: a review of studies in experimental animals.
abstract: Diesel exhaust (DE) is a complex mixture of combustion products of diesel fuel, including gases and diesel exhaust particles (DEPs), commonly known as soot, that contains many toxic air contaminants. Studies of pre- and postnatal exposure to DE or DEPs have revealed changes in growth, sexual development, hormone levels, spermatogenesis, weights of the reproductive and accessory organs, behavior, monoaminergic system, expression of immune-related genes, histopathology of the testes and brain, susceptibility to allergies, and inflammatory and genotoxic endpoints in rodent offspring. Changes in gene expression for gonadal development were also observed after exposure to DE. As for the causative agent for the developmental toxicity of DE, DEPs and the gaseous phase, conflicting findings were reported. Although this paper provides initial information on the potential developmental toxicity of DE including the gaseous phase and DEPs, further studies using relevant concentrations closely reflecting expected levels of human exposure are needed.
authors.affiliation: Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST), 16-1 Onogawa, Tsukuba, Ibaraki 305-8569, Japan. Electronic address: ema-makoto@aist.go.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ema
authors.forename: Masato
authors.initials: M
authors.lastname: Naya
authors.forename: Masao
authors.initials: M
authors.lastname: Horimoto
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Kato
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D005260:Female; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012098:Reproduction / Q000187:drug effects; D053260:Soot / Q000633:toxicity*; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D053260:Soot; D001335:Vehicle Emissions
keywords: Carbon black; Developmental toxicity; Diesel exhaust; Diesel exhaust particles; Nanoparticles; Reproductive system; Reproductive toxicity; Testicular toxicity