title: Role of extracellular GAPDH in Streptococcus pyogenes virulence.
abstract: Pathogens generate molecules, or virulence factors, that enable them to colonize host tissues through several mechanisms, including adhesion to host tissues, or superior invasive capability. Some allow the pathogen to evade the host's immune system. Many of these molecules are proteins that are exported to the cell's surface or secreted. Curiously, GAPDH, which is a glycolytic enzyme, is also a virulence factor that has been shown to contribute to Streptococcus pyogenes pathogenicity by each of these mechanisms.
authors.affiliation: University of Missouri, USA.
authors.forename: Kirsten A
authors.initials: KA
authors.lastname: Seidler
authors.forename: Norbert W
authors.initials: NW
authors.lastname: Seidler
mesh_terms: D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000276:immunology / Q000378:metabolism; D006801:Humans; D013297:Streptococcus pyogenes / Q000201:enzymology* / Q000276:immunology* / Q000472:pathogenicity*; D014774:Virulence; D037521:Virulence Factors / Q000276:immunology* / Q000378:metabolism*
chemical_list: D037521:Virulence Factors; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases