title: p66Shc, mitochondria, and the generation of reactive oxygen species.
abstract: Reactive oxygen species (ROS), mainly originated from mitochondrial respiration, are critical inducers of oxidative damage and involved in tissue dysfunction. It is not clear, however, whether oxidative stress is the result of an active gene program or it is the by-product of physiological processes. Recent findings demonstrate that ROS are produced by mitochondria in a controlled way through specialized enzymes, including p66Shc, and take part in cellular process aimed to ensure adaptation and fitness. Therefore, genes generating specifically ROS are selected determinants of life span in response to different environmental conditions.
authors.affiliation: Department of experimental Oncology, European Institute of Oncology, Milan, Italy.
authors.forename: Mirella
authors.initials: M
authors.lastname: Trinei
authors.forename: Enrica
authors.initials: E
authors.lastname: Migliaccio
authors.forename: Paolo
authors.initials: P
authors.lastname: Bernardi
authors.forename: Francesco
authors.initials: F
authors.lastname: Paolucci
authors.forename: Piergiuseppe
authors.initials: P
authors.lastname: Pelicci
authors.forename: Marco
authors.initials: M
authors.lastname: Giorgio
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001833:Body Temperature Regulation / Q000502:physiology; D016572:Cyclosporine / Q000494:pharmacology; D055664:Electrochemical Techniques; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005033:Ethylmaleimide / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D033681:Mitochondrial Membrane Transport Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D000083162:Mitochondrial Permeability Transition Pore; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000819:agonists* / Q000378:metabolism; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology; D055765:Shc Signaling Adaptor Proteins / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D015398:Signal Transduction; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D020033:Protein Isoforms; D017382:Reactive Oxygen Species; D011994:Recombinant Proteins; C528024:SHC1 protein, human; D055765:Shc Signaling Adaptor Proteins; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D016572:Cyclosporine; D005033:Ethylmaleimide
keywords: Aging; Apoptosis; Mitochondria; Oxidative stress