title: Perforated duodenal ulcer: a rare complication of deferasirox in children.
abstract: Duodenal ulcer perforation in pediatric age group is an uncommon entity; hence, it is not usually considered in the differential diagnosis of acute abdomen in these patients. It is important for the emergency physician to consider perforated peptic ulcer in the differential diagnosis of children presenting with acute abdominal pain, gastrointestinal bleeding, or shock. We report a 6½-year-old male child with thalassemia major who presented to emergency room with an acute abdomen and shock, who was subsequently found to have a perforated duodenal ulcer, probably related to use of oral chelating agent, deferasirox. Although, gastrointestinal symptoms like nausea, vomiting, and abdominal pain has been mentioned as infrequent adverse event in the scientific product information of deferasirox, in our current knowledge this is the first case report of perforated duodenal ulcer after oral deferasirox. The severity of this event justifies the reporting of this case. This patient had an atypical presentation in that there were no signs or symptoms of peptic ulcer disease before perforation and shock he was successfully managed with open surgery after initial resuscitation and stabilization of his general condition.
authors.affiliation: Department of Pediatric Surgery, IBN Sina Hospital, Kuwait.
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Yadav
authors.forename: Vipul
authors.initials: V
authors.lastname: Gupta
authors.forename: Ashraf
authors.initials: A
authors.lastname: El Kohly
authors.forename: Wasmi
authors.initials: W
authors.lastname: Al Fadhli
mesh_terms: D001565:Benzoates / Q000009:adverse effects*; D002648:Child; D000077588:Deferasirox; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007502:Iron Chelating Agents / Q000009:adverse effects*; D008297:Male; D010439:Peptic Ulcer Perforation / Q000139:chemically induced* / Q000175:diagnosis; D014230:Triazoles / Q000009:adverse effects*; D017086:beta-Thalassemia / Q000188:drug therapy
chemical_list: D001565:Benzoates; D007502:Iron Chelating Agents; D014230:Triazoles; D000077588:Deferasirox
keywords: Chelating agent; deferasirox; duodenal perforation