title: Changes on metabolic parameters induced by acute cannabinoid administration (CBD, THC) in a rat experimental model of nutritional vitamin A deficiency.
abstract: BACKGROUND
  Vitamin A deficiency can result from malnutrition, malabsorption of vitamin A, impaired vitamin metabolism associated with liver disease, or chronic debilitating diseases like HIV infection or cancer.
  
  
  OBJECTIVE
  Cannabis administration has been described as a palliative symptom management therapy in such pathological stages. Therefore, this research aimed to study the effects of acute administration of cannabidiol (CBD) or thetrahydrocannabinol (THC) on the levels of retinol in plasma and in the liver, and biochemical parameters related to lipid and glucose metabolism (cholesterolaemia, triglyceridemia and glycemia) in a rat experimental model of vitamin A deficiency.
  
  
  METHODS
  The experimental animal model of Vitamin A deficiency was developed during a 50-day experimental period in which rats consumed a vitamin A-free diet. Cannabidiol (10 mg/kg body weight) or thetrahydrocannabinol (5 mg/kg body weight) were administered intraperitoneally 2 hours prior to sacrifice of the animals.
  
  
  RESULTS
  The nutritional deficiency caused a significant decrease in plasmatic and liver contents of retinol and biochemical parameters of glycemic, lipidic, and mineral metabolism. Acute intraperitoneal administration of Cannabidiol and thetrahydrocannabinol did not improve the indices of vitamin A status in either control or vitamin A-deficient rats. However, it had a significant effect on specific biochemical parameters such as glucose, triglycerides, and cholesterol.
  
  
  CONCLUSIONS
  Under our experimental conditions, the reported effects of cannabinoid administration on certain signs of nutritional vitamin A deficiency appeared to be mediated through mechanisms other than changes in retinol metabolism or its mobilization after the acute administration of such compounds.
authors.affiliation: Department of Physiology, School of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain.
authors.forename: Loubna
authors.initials: L
authors.lastname: El Amrani
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Porres
authors.forename: Abderrahmane
authors.initials: A
authors.lastname: Merzouki
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: Louktibi
authors.forename: Pilar
authors.initials: P
authors.lastname: Aranda
authors.forename: María
authors.initials: M
authors.lastname: López-Jurado
authors.forename: Gloria
authors.initials: G
authors.lastname: Urbano
mesh_terms: D000818:Animals; D002185:Cannabidiol / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D013759:Dronabinol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014802:Vitamin A Deficiency / Q000378:metabolism*
chemical_list: D002185:Cannabidiol; D013759:Dronabinol