title: Optimization of physico-chemical properties of carbon enterosorbents and evaluation of their sorption activity for use in the treatment of paraneoplastic syndrome and other endogenous intoxications in cancer patients.
abstract: OBJECTIVE
  Development of carbon enterosorbents with optimal physical-chemical properties and high adsorptive capacity for their usage in the treatment of paraneoplastic syndrome and other endogenous intoxication in cancer patients.
  
  
  METHODS
  physical-chemical and biochemical methods of investigation.
  
  
  RESULTS
  In the work it has been shown that performance of additional steam activation on pilot plant developed in R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, allows produce highly active granulated and fibrous carbon enterosorbents which possess well developed porous surface providing potent sorption potential toward compounds of hydrophilic and hydrophobic nature. Being placed in gastro-intestinal tract lumen these sorbents may cause certain effect on functional activity of detoxifying body systems and regeneration potential of many organs and tissues.
  
  
  CONCLUSIONS
  The usage of carbon enterosorbents with optimal physical-chemical properties and high adsorptive capacity could be very perspective for correction of biochemical, immunologic, morphologic and hematological manifestations of paraneoplastic syndrome.
authors.affiliation: R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine. vsnikavera@mail.ru
authors.forename: V V
authors.initials: VV
authors.lastname: Sarnatskaya
authors.forename: A S
authors.initials: AS
authors.lastname: Sidorenko
authors.forename: D A
authors.initials: DA
authors.lastname: Klymchuk
authors.forename: I M
authors.initials: IM
authors.lastname: Khohulya
authors.forename: L A
authors.initials: LA
authors.lastname: Yushko
authors.forename: V N
authors.initials: VN
authors.lastname: Maslenniy
authors.forename: V G
authors.initials: VG
authors.lastname: Nikolaev
mesh_terms: D000327:Adsorption; D001663:Bilirubin / Q000737:chemistry; D002244:Carbon; D004396:Coloring Agents / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry; D016061:Enterosorption / Q000379:methods*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D010257:Paraneoplastic Syndromes / Q000628:therapy*; D016062:Porosity; D012709:Serum Albumin / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004396:Coloring Agents; D012709:Serum Albumin; D002244:Carbon; D004317:Doxorubicin; D001663:Bilirubin