title: Adenosquamous carcinoma of the head and neck: report of 20 cases and review of the literature.
abstract: OBJECTIVE
  To assess the clinical profile and prognostic factors in patients with adenosquamous carcinoma (ASC) of the head and neck treated by surgery and/or radiation therapy with or without chemotherapy.
  
  
  METHODS
  Data from 20 patients with stage I-II (n = 4), III (n = 5), or IVA (n = 11) head and neck ASC, treated between 1989 and 2010 were collected in a retrospective multicenter Rare Cancer Network study. Surgery was performed in 16 patients. Seventeen patients received combined modality treatment.
  
  
  RESULTS
  After a median follow-up of 15.5 months, 12 patients recurred. The 3-year and median overall survival, disease-free survival (DFS), and loco-regional control were 52% and 39 months, 32% and 12 months, and 47% and 33 months respectively. In multivariate analysis, DFS was negatively influenced by the presence of extracapsular extension and advanced stage.
  
  
  CONCLUSIONS
  Overall prognosis of locoregionally advanced ASC remains poor. However, early stage ASC patients managed with combined modality treatment may have prolonged DFS.
authors.affiliation: Department of Radiation Oncology, University Hospital of Geneva, Geneva, Switzerland. ulrike.schick@icr.ac.uk
authors.forename: Ulrike
authors.initials: U
authors.lastname: Schick
authors.forename: Marc
authors.initials: M
authors.lastname: Pusztaszeri
authors.forename: Michael
authors.initials: M
authors.lastname: Betz
authors.forename: Pirus
authors.initials: P
authors.lastname: Ghadjar
authors.forename: Candan
authors.initials: C
authors.lastname: Demiroz
authors.forename: Johannes H A M
authors.initials: JH
authors.lastname: Kaanders
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ozsahin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018196:Carcinoma, Adenosquamous / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D035583:Rare Diseases / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate; D013557:Switzerland / Q000453:epidemiology; D014421:Turkey / Q000453:epidemiology