title: Predictive markers for carbamazepine and lamotrigine-induced maculopapular exanthema in Han Chinese.
abstract: The aims of this study were to clarify the possible associations of carbamazepine (CBZ)- and lamotrigine (LTG)-induced maculopapular exanthema (MPE) with the human leukocyte antigen (HLA) alleles in Chinese patients. A total of 249 subjects, including 40 patients with CBZ-induced MPE (CBZ-MPE), 43 patients with LTG-induced MPE (LTG-MPE), 52 CBZ-tolerant controls, 42 LTG-tolerant controls and 72 healthy controls, were included in this study. High-resolution HLA genotyping was performed by a specific kit. Differences in the allele frequencies among the groups were assessed. The allele frequencies of HLA-A*0201 and HLA-DRB1*1405 were significantly higher (P=0.033 and P=0.003, respectively), but those of HLA-B*5801 and HLA-DRB1*0301 (P=0.037 and P=0.024, respectively) were lower in the CBZ-MPE patients when compared with the CBZ-tolerant group. We also observed two significantly increased alleles of HLA-A*3001 and HLA-B*1302 (P=0.013 and P=0.013, respectively) and a decreased allele of HLA-A*3303 (P=0.048) in the LTG-MPE patients when compared with those in the LTG-tolerant group. Our results support the hypothesis that these HLA alleles contribute to the genetic susceptibility to CBZ/LTG-MPE and may be valuable as potential biomarkers for CBZ/LTG-MPE in Han Chinese.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Li
authors.forename: Fa-Yun
authors.initials: FY
authors.lastname: Hu
authors.forename: Xin-Tong
authors.initials: XT
authors.lastname: Wu
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: An
authors.forename: Bo
authors.initials: B
authors.lastname: Yan
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000483:Alleles; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D044466:Asian People; D015415:Biomarkers; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003875:Drug Eruptions / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D059910:HLA-B15 Antigen / Q000235:genetics; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D008875:Middle Aged; D010267:Parapsoriasis / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D011237:Predictive Value of Tests; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D015415:Biomarkers; D015235:HLA-B Antigens; C483536:HLA-B*15:02 antigen; D059910:HLA-B15 Antigen; D014227:Triazines; D002220:Carbamazepine; D000077213:Lamotrigine
keywords: Carbamazepine; Human leukocyte antigen; Lamotrigine; Maculopapular exanthema