title: Morpholino-decorated long circulating polymeric micelles with the function of surface charge transition triggered by pH changes.
abstract: Micelles with surface morpholino groups were stealthy at blood and normal tissue pH (7.4) due to the unprotonated hydrophilic morpholino groups on the surfaces. At tumor pH (<7), the micelle surfaces were positively charged because of the protonation of the morpholino groups, which promoted the cellular uptake of the micelles.
authors.affiliation: Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chenhong
authors.initials: C
authors.lastname: Wang
authors.forename: Chuang
authors.initials: C
authors.lastname: Xu
authors.forename: Cuiping
authors.initials: C
authors.lastname: Yang
authors.forename: Zhenqing
authors.initials: Z
authors.lastname: Zhang
authors.forename: Husheng
authors.initials: H
authors.lastname: Yan
authors.forename: Keliang
authors.initials: K
authors.lastname: Liu
mesh_terms: D000588:Amines / Q000737:chemistry; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D008954:Models, Biological; D060172:Morpholinos / Q000737:chemistry*; D017239:Paclitaxel / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry*
chemical_list: D000588:Amines; D008823:Micelles; D060172:Morpholinos; D011108:Polymers; D017239:Paclitaxel