title: Protein interaction networks in innate immunity.
abstract: The immune response to pathogens is controlled by complex and tightly regulated molecular networks. Recent technological advances have empowered approaches to investigate innate immune signaling and monitor host-pathogen interactions at a systems level. Protein complexes are key players in pathogen recognition and integrate much of the host molecular responses that occur at the transcriptional and translational level. The ability to monitor protein complex abundance, dynamics, and composition is therefore important to understand the ability of cells to mount the appropriate immune response. Here, we focus on current proteomics technologies applied to identify the protein complexes involved, and highlight recent studies illustrating the power of these approaches to unravel how the dedicated molecular machinery is integrated with other cellular processes to safeguard homeostasis.
authors.affiliation: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
authors.forename: Manuele
authors.initials: M
authors.lastname: Rebsamen
authors.forename: Richard Kumaran
authors.initials: RK
authors.lastname: Kandasamy
authors.forename: Giulio
authors.initials: G
authors.lastname: Superti-Furga
mesh_terms: D006801:Humans; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology*; D060066:Protein Interaction Maps / Q000235:genetics* / Q000276:immunology*; D020543:Proteome / Q000235:genetics* / Q000276:immunology*; D040901:Proteomics / Q000379:methods; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology
chemical_list: D020543:Proteome
keywords: innate immunity; mass spectrometry; protein complex; proteomics; systems biology