title: Repeated "all out" interval exercise causes an increase in serum hepcidin concentration in both trained and untrained men.
abstract: This investigation assessed effects of high-intensity interval exercise (HIE; triple Wingate anaerobic test) on inflammatory markers, iron metabolism and hepcidin concentrations. Group of highly trained judo athletes (TR) and non-trained control males (CG) completed a triple Wingate test separated by 4.5min rest. Venous blood samples were collected before, immediately after, 1h, 24h, and 5days following exercise and analysed for serum of IL-6, IL-10, iron, and ferritin. Physiological response to exercise was also determined. Concentration of IL-6 and hepcidin increased 1h after exercise in both groups (p<0.05). Hepcidin returned post testing 24h in TR, whereas in CG it remained elevated during 5days following exercise. Changes in hepcidin did not correlate with shifts in serum IL-6, iron and ferritin concentrations. Gathered data suggest that following HIE, hepcidin increased independently of IL-6 and neither blood nor storage iron affected this phenomena.
authors.affiliation: Warsaw School of Social Sciences and Humanities, Department of Sport Psychology, Poland.
authors.forename: Jędrzej
authors.initials: J
authors.lastname: Antosiewicz
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Kaczor
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kasprowicz
authors.forename: Radosław
authors.initials: R
authors.lastname: Laskowski
authors.forename: Sylwester
authors.initials: S
authors.lastname: Kujach
authors.forename: Marcin
authors.initials: M
authors.lastname: Luszczyk
authors.forename: Lukasz
authors.initials: L
authors.lastname: Radziminski
authors.forename: Ewa
authors.initials: E
authors.lastname: Ziemann
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D056352:Athletes; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise / Q000502:physiology*; D064451:Hepcidins; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010807:Physical Endurance / Q000502:physiology; D055815:Young Adult
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D015850:Interleukin-6
keywords: Cytokines; Iron; Triple Wingate test