title: Eyes-open/eyes-closed dataset sharing for reproducibility evaluation of resting state fMRI data analysis methods.
abstract: The multi-scan resting state fMRI (rs-fMRI) dataset was recently released; thus the test-retest (TRT) reliability of rs-fMRI measures can be assessed. However, because this dataset was acquired only from a single group under a single condition, we cannot directly evaluate whether the rs-fMRI measures can generate reproducible between-condition or between-group results. Because the modulation of resting state activity has gained increasing attention, it is important to know whether one rs-fMRI metric can reliably detect the alteration of the resting activity. Here, we shared a public Eyes-Open (EO)/Eyes-Closed (EC) dataset for evaluating the split-half reproducibility of the rs-fMRI measures in detecting changes of the resting state activity between EO and EC. As examples, we assessed the split-half reproducibility of three widely applied rs-fMRI metrics: amplitude of low frequency fluctuation, regional homogeneity, and seed-based correlation analysis. Our results demonstrated that reproducible patterns of EO-EC differences can be detected by all three measures, suggesting the feasibility of the EO/EC dataset for performing reproducibility assessment for other rs-fMRI measures.
authors.affiliation: Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, 310015, China, charlesliu116@gmail.com.
authors.forename: Dongqiang
authors.initials: D
authors.lastname: Liu
authors.forename: Zhangye
authors.initials: Z
authors.lastname: Dong
authors.forename: Xinian
authors.initials: X
authors.lastname: Zuo
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zang
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D005123:Eye; D005260:Female; D006801:Humans; D033181:Information Dissemination; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D015203:Reproducibility of Results; D012146:Rest / Q000502:physiology*; D055815:Young Adult