title: The gut-brain axis in the critically ill: is glucagon-like peptide-1 protective in neurocritical care?
abstract: Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has immune-modulatory and neuroprotective effects. To determine whether these immune-modulatory and neuroprotective effects of GLP-1 are beneficial in the critically ill, studies achieving pharmacological GLP-1 concentrations are warranted.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Plummer
authors.forename: Juris J
authors.initials: JJ
authors.lastname: Meier
authors.forename: Adam M
authors.initials: AM
authors.lastname: Deane
mesh_terms: D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D007362:Intensive Care Units; D008297:Male
chemical_list: D052216:Glucagon-Like Peptide 1