title: Capturing the mammalian Hippo: elucidating its role in cancer.
abstract: The Hippo pathway is an evolutionarily conserved kinase cascade involved in cell growth, apoptosis, development and migration. It is also crucial for stem cell self-renewal and the maintenance of genomic stability. In addition, this pathway has the unique capacities to sense aspects of tissue architecture, such as cell polarity and mechanical tensions imposed by the surrounding microenvironment, and to control organ size and shape. All of these properties are frequently altered in tumor cells. In this review, we summarize how dysregulation of mammalian Hippo signaling is implicated in cancer.
authors.affiliation: Division of Cancer Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Nishio
authors.forename: Kohei
authors.initials: K
authors.lastname: Otsubo
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Maehama
authors.forename: Koshi
authors.initials: K
authors.lastname: Mimori
authors.forename: Akira
authors.initials: A
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D029721:Drosophila Proteins / Q000502:physiology; D004789:Enzyme Activation; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008322:Mammals / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D009363:Neoplasm Proteins / Q000502:physiology*; D009369:Neoplasms / Q000201:enzymology*; D009857:Oncogenes; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity; D013234:Stem Cells / Q000502:physiology; D000099317:Hippo Kinases
chemical_list: D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D017346:Protein Serine-Threonine Kinases; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases