title: The angiopoietin-like protein 3: a hepatokine with expanding role in metabolism.
abstract: OBJECTIVE
  Cumulating evidence are revealing roles of angiopoietin-like proteins (ANGPTLs) in lipid, glucose, and energy metabolism. In this review, we discuss the recent developments in understanding the specific role in metabolic processes of the liver-derived ANGPTL3.
  
  
  RESULTS
  Several groups have reported clinical and metabolic characterization of individuals with loss-of-function variants in ANGPTL3 showing familial combined hypolipidemia, a syndrome characterized by marked reduction of all plasma lipoproteins. Their findings indicate that in humans, ANGPTL3 has a broader action on apoB and apoA-I-containing lipoproteins, as well as on free fatty acid and adipose tissue metabolism.
  
  
  CONCLUSIONS
  The identification of loss-of-function ANGPTL3 mutation is shedding light on a possible role of ANGPTL3 at the crossroads of lipoproteins, fatty acids, and glucose metabolism, thus making ANGPTL3 an attractive protein to target the cardio-metabolic risk.
authors.affiliation: Dipartimento di Medicina, Interna e Specialità Mediche Sapienza Università di Roma, Rome, Italy. marcelloarca@libero.it
authors.forename: Marcello
authors.initials: M
authors.lastname: Arca
authors.forename: Ilenia
authors.initials: I
authors.lastname: Minicocci
authors.forename: Marianna
authors.initials: M
authors.lastname: Maranghi
mesh_terms: D000091303:Angiopoietin-Like Protein 3; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000502:physiology*; D000818:Animals; D050171:Dyslipidemias / Q000097:blood / Q000235:genetics; D005227:Fatty Acids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000378:metabolism; D020125:Mutation, Missense
chemical_list: C479896:ANGPTL3 protein, human; D000091303:Angiopoietin-Like Protein 3; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D005227:Fatty Acids; D008074:Lipoproteins; D005947:Glucose