title: Bonding strength of glass-ceramic trabecular-like coatings to ceramic substrates for prosthetic applications.
abstract: A new approach based on the concepts of quantized fracture mechanics (QFM) is presented and discussed in this paper to estimate the bonding strength of trabecular-like coatings, i.e. glass-ceramic scaffolds mimicking the architecture of cancellous bone, to ceramic substrates. The innovative application of glass-derived scaffolds as trabecular-like coatings is proposed in order to enhance the osteointegration of prosthetic ceramic devices. The scaffolds, prepared by polymeric sponge replication, are joined to alumina substrates by a dense glass-ceramic coating (interlayer) and the so-obtained 3-layer constructs are investigated from micro-structural, morphological and mechanical viewpoints. In particular, the fracture strengths of three different crack propagation modes, i.e. glass-derived scaffold fracture, interface delamination or mixed fracture, are predicted in agreement with those of experimental mechanical tests. The approach proposed in this work could have interesting applications towards an ever more rational design of bone tissue engineering biomaterials and coatings, in view of the optimization of their mechanical properties for making them actually suitable for clinical applications.
authors.affiliation: Laboratory of Biomechanics, School of Biological Science and Medical Engineering, Southeast University, 210096, Nanjing, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.forename: Francesco
authors.initials: F
authors.lastname: Baino
authors.forename: Nicola M
authors.initials: NM
authors.lastname: Pugno
authors.forename: Chiara
authors.initials: C
authors.lastname: Vitale-Brovarone
mesh_terms: D000268:Adhesiveness; D001672:Biocompatible Materials / Q000737:chemistry; D002516:Ceramics / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D017640:Silicates / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013314:Stress, Mechanical; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D017640:Silicates
keywords: Coating; Glass; Osteointegration; Quantized fracture mechanics; Scaffold