title: Cyplecksins are covalent inhibitors of the pleckstrin homology domain of cytohesin.
authors.affiliation: Life and Medical Sciences Institute, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hussein
authors.forename: Martina
authors.initials: M
authors.lastname: Bettio
authors.forename: Anton
authors.initials: A
authors.lastname: Schmitz
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Hannam
authors.forename: Julian
authors.initials: J
authors.lastname: Theis
authors.forename: Günter
authors.initials: G
authors.lastname: Mayer
authors.forename: Stefan
authors.initials: S
authors.lastname: Dosa
authors.forename: Michael
authors.initials: M
authors.lastname: Gütschow
authors.forename: Michael
authors.initials: M
authors.lastname: Famulok
mesh_terms: D020816:Amino Acid Motifs; D001665:Binding Sites; D004353:Drug Evaluation, Preclinical; D015180:Electrophoresis, Gel, Two-Dimensional; D049452:Green Fluorescent Proteins / Q000737:chemistry; D020662:Guanine Nucleotide Exchange Factors / Q000037:antagonists & inhibitors* / Q000737:chemistry; D006367:HeLa Cells; D057166:High-Throughput Screening Assays; D006801:Humans; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry; D011744:Pyrimidinones / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D020662:Guanine Nucleotide Exchange Factors; D011506:Proteins; D011744:Pyrimidinones; C586993:cyplecksin 1; C100723:cytohesin-1; D049452:Green Fluorescent Proteins
keywords: Cyplecksins; aptamers; cytohesin; drug development; inhibitors