title: Diuretic use in heart failure and outcomes.
abstract: Diuretics are frequently administered to relieve congestive symptoms in patients with heart failure (HF). Despite their widespread use, prospective data on the potential of diuretics to modulate HF-related morbidity and mortality are scarce. Diuretic efficacy may be limited by adverse neurohormonal activation and by "congestion-like" symptoms that may occur in the absence of fluid overload. Herein, we review the current knowledge on diuretic use and outcomes in HF.
authors.affiliation: 1] Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia [2] Alfred Hospital, Melbourne, Australia [3] Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway [4] Institute of Clinical Sciences, University of Oslo, Oslo, Norway.
authors.forename: T G
authors.initials: TG
authors.lastname: von Lueder
authors.forename: D
authors.initials: D
authors.lastname: Atar
authors.forename: H
authors.initials: H
authors.lastname: Krum
mesh_terms: D065092:Antidiuretic Hormone Receptor Antagonists; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008954:Models, Biological; D017410:Practice Guidelines as Topic; D058915:Purinergic P1 Receptor Antagonists / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D004232:Diuretics; D058915:Purinergic P1 Receptor Antagonists