title: Ewing sarcoma of the adrenal gland: a rare entity.
abstract: A 63-year-old man was referred to our office with an enlarging left adrenal mass found on work-up for prostate cancer. Imaging performed over the course of 6 months demonstrated an increasing left adrenal mass from 2.8 to 3.6 cm. Functional testing of the adrenal lesion was performed. The adrenal mass was non-functional. Owing to the enlarging size, the patient underwent a laparoscopic left adrenalectomy without complication and was discharged home the following day. Gross pathological evaluation demonstrated a 3.2 cm, well-encapsulated, partially cystic mass. Histological evaluation demonstrated a small round blue cell tumour suspicious of sarcoma. Immunohistochemical testing revealed strong CD99 positivity consistent with Ewing family of tumours. Reverse transcriptase PCR demonstrated the presence of the Ewing sarcoma fusion transcript. The patient is currently enrolled in an ongoing research chemotherapy protocol at our institution using vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide.
authors.affiliation: Department of Surgery, Mayo Clinic in Arizona, Phoenix, Arizona, USA.
authors.forename: Joseph-Vincent V
authors.initials: JV
authors.lastname: Blas
authors.forename: Maxwell L
authors.initials: ML
authors.lastname: Smith
authors.forename: Nabil
authors.initials: N
authors.lastname: Wasif
authors.forename: Curtiss B
authors.initials: CB
authors.lastname: Cook
authors.forename: Richard T
authors.initials: RT
authors.lastname: Schlinkert
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012512:Sarcoma, Ewing / Q000175:diagnosis*