title: An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases.
abstract: The production of metallo-β-lactamases is the most important strategy by which pathogenic bacteria become resistant to currently known β-lactam antibiotics. The emergence of these enzymes is particularly concerning for the future treatment of bacterial infections. There are no clinically available drugs capable of inhibiting any of the metallo-β-lactamases, so there is an urgent need to find such inhibitors. In this review, an up-to-date status of the inhibitors investigated for the inhibition of metallo-β-lactamases has been given so that this rich source of structural information of presently known metallo-β-lactamases could be helpful in generating a broad-spectrum potent inhibitor of metallo-β-lactamases.
authors.affiliation: Chemistry Department, Islamia College University, Peshawar-25120, Pakistan.
authors.lastname: Faridoon
authors.forename: Nazar
authors.initials: N
authors.lastname: Ul Islam
keywords: Biphenyl tetrazoles; Inhibition; Metallo-beta-lactamases; Peptides; Thiol; Triazoles; β-Lactam analogues