title: Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer.
abstract: DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging 'hallmark' of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.
authors.affiliation: Laboratory of Signal Transduction, Department of Anesthesiology, Kodog Ageing Center, Mayo Clinic Cancer Center and Mayo Clinic College of Medicine, Rochester, MN 55905, U.S.A. chini.eduardp@mayo.edu).
authors.forename: Eduardo Nunes
authors.initials: EN
authors.lastname: Chini
authors.forename: Claudia C S
authors.initials: CC
authors.lastname: Chini
authors.forename: Veronica
authors.initials: V
authors.lastname: Nin
authors.forename: Carlos
authors.initials: C
authors.lastname: Escande
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000375:Aging; D000818:Animals; D004734:Energy Metabolism; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D017381:Spliceosomes / Q000378:metabolism; D000099186:Histone Deacetylase 3
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D006655:Histone Deacetylases; D006657:Histones; D000099186:Histone Deacetylase 3; C527450:CCAR2 protein, human