title: Production, Quality Control and Biological Evaluation of (166)Ho-PDTMP as a Possible Bone Palliation Agent.
abstract: OBJECTIVE
  In this study, (166)Ho-1,2-propylene di-amino tetra(methy1enephosphonicAcid) ((166)Ho-PDTMP) complex was prepared as a bone palliation agent.
  
  
  METHODS
  The complex was successfully prepared using an in-house synthesized EDTMP ligand and (166)HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 n.cm-2.s-1) of natural Ho(NO3)3 samples followed by radiolabeling and stability studies. Biodistribution in wild type rats was also peformed.
  
  
  RESULTS
  The complex was prepared with the specific activity of 278 GBq/mg and high radiochemical purity (>99%, checked by ITLC). (166)Ho-PDTMP complex was stabilized in the final preparation and in the presence of human serum (>90%) up to 72 hr. The biodistribution of (166)Ho-PDTMP in wild-type rats demonstrated significant bone uptake was up to 48 hr compared to (166)HoCl3.
  
  
  CONCLUSIONS
  The produced (166)Ho-PDTMP properties suggest a possible new bone palliative therapeutic to overcome the metastatic bone pains.
authors.affiliation: Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran ; Faculty of Energy Engineering and Physics, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Zolghadri
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Jalilian
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Naseri
authors.forename: Hassan
authors.initials: H
authors.lastname: Yousefnia
authors.forename: Ali
authors.initials: A
authors.lastname: Bahrami-Samani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghannadi-Maragheh
authors.forename: Hossein
authors.initials: H
authors.lastname: Afarideh
keywords: 166Ho; Biodistribution; PDTMP; Radiopharmaceutical; Therapy