title: [Bacterial pigment prodigiosin and its genotoxic effects].
abstract: The prodigiosin preparation was isolated and purified from Serratia marcescens ATCC 9986, using chromatographic methods. The analysis of the preparation by TLC, NMR-spectrometry and mass-spectrometry allowed to confirm the red pigment fraction as the prodigiosin and detect its purity. Originally, the specific features of the toxic and genotoxic effects of prodigiosin and the possibility of induction of mutations by pigment in the cells of Salmonella typhimurium TA 100 (Ames test) and chromosome damage of mammalian erythroblasts have been determined.
authors.forename: I D
authors.initials: ID
authors.lastname: Gur'ianov
authors.forename: N S
authors.initials: NS
authors.lastname: Karamova
authors.forename: D V
authors.initials: DV
authors.lastname: Iusupova
authors.forename: O I
authors.initials: OI
authors.lastname: Gnezdilov
authors.forename: L A
authors.initials: LA
authors.lastname: Koshkarova
mesh_terms: D000818:Animals; D004249:DNA Damage; D008099:Liver / Q000166:cytology / Q000187:drug effects; D013058:Mass Spectrometry; D009153:Mutagens / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D011353:Prodigiosin / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D012706:Serratia marcescens / Q000737:chemistry
chemical_list: D009153:Mutagens; D010860:Pigments, Biological; D011353:Prodigiosin