title: Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis.
abstract: BACKGROUND
  The potentially functionally relevant IL10 -1082A>G (rs1800896) promoter region single-nucleotide polymorphism has been implicated in the pathogenesis of atopic dermatitis (AD). Although this relationship has been studied extensively, these association studies were limited by small sample size.
  
  
  OBJECTIVE
  To increase statistical power and obtain a more precise estimate of the association, literature evidence on IL10 -1082A>G and AD was assessed by conducting a systematic review and meta-analysis.
  
  
  METHODS
  This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed (MEDLINE), EMBASE, Scopus, and HuGE Literature Finder literature databases were systematically searched for relevant studies. Summary odds ratios and corresponding 95% confidence intervals were estimated using the fixed-effect inverse variance analysis method for allelic (G vs A) and genotypic comparisons.
  
  
  RESULTS
  Meta-analysis of 7 studies (n = 849 cases and 1195 controls) found a nonsignificant association between the IL10 -1082A>G polymorphism and AD (allelic odds ratio, 1.02; 95% confidence interval, 0.88-1.19; P = 0.77).
  
  
  CONCLUSIONS
  This study was unable to find a direct association between IL10 -1082A>G and AD. Further studies are needed to reveal the contributions of haplotype and gene-gene and gene-environment interaction effects involving this single-nucleotide polymorphism to AD.
authors.affiliation: University of Medicine and Health Sciences, New York, NY, USA.
authors.forename: Suzan
authors.initials: S
authors.lastname: Chen
authors.forename: Linlu
authors.initials: L
authors.lastname: Zhao
mesh_terms: D003876:Dermatitis, Atopic / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D016753:Interleukin-10