title: [Analysis of neutrophil gelatinase-associated lipocalin in the critical patient].
abstract: OBJECTIVE
  To determine if NGAL value exceeding 150 ng/mL is a good diagnostic test for acute renal failure in critically ill patients.
  
  
  METHODS
  Prospective, observational cohort.
  
  
  METHODS
  Intensive Care Unit and Cardiac Surgery Intensive Care Service at Hospital Germans Trias I Pujol.
  
  
  METHODS
  Patients admitted to the Intensive Care department the Designated days in the studio.
  
  
  METHODS
  Analysis of serum creatinine blood given from 7 days prior to the start of the study, and daily during 4 weeks and by determination of NGAL urine test in frozen sample, analyzer ARCHITECT (Abbott Diagnostics) determined by immunoassay the day baseline and 2 times a week for 4 weeks, analysis of the stay and mortality.
  
  
  RESULTS
  A total of 529 NGAL samples were obtained from 46 patients. 37% of patients had a value of NGAL>150 ng/mL. The Sensivity of the test to diagnose acute renal failure was 69%, Specifity was 75,7%. However, the Positive Predictive Test Value was 53%, which means that 47% of patients with high NGAL did not develop AKI. A NGAL >150 mg/dL was associated with a significantly higher SOFA and a longer stay in the ICU. The mortality of patients with elevated NGAL was 58.8%.
  
  
  CONCLUSIONS
  A NGAL>150 ng/mL does not seem to be an excellent test for AKI in critically ill patients but is associated with a worse prognosis.
authors.affiliation: Servicio de Medicina Intensiva, Bioquímica, Cirugía y Epidemiología, Hospital Universitari Germans Trias i Pujol, Badalona, España. Electronic address: claramarti@yahoo.com.
authors.forename: C
authors.initials: C
authors.lastname: Marti-Macia
authors.affiliation: Servicio de Medicina Intensiva, Bioquímica, Cirugía y Epidemiología, Hospital Universitari Germans Trias i Pujol, Badalona, España.
authors.forename: T M
authors.initials: TM
authors.lastname: Tomasa
authors.affiliation: Servicio de Medicina Intensiva, Bioquímica, Cirugía y Epidemiología, Hospital Universitari Germans Trias i Pujol, Badalona, España.
authors.forename: A
authors.initials: A
authors.lastname: Sancho
authors.affiliation: Servicio de Medicina Intensiva, Bioquímica, Cirugía y Epidemiología, Hospital Universitari Germans Trias i Pujol, Badalona, España.
authors.forename: A
authors.initials: A
authors.lastname: Galán
authors.affiliation: Servicio de Medicina Intensiva, Bioquímica, Cirugía y Epidemiología, Hospital Universitari Germans Trias i Pujol, Badalona, España.
authors.forename: J
authors.initials: J
authors.lastname: Fernández-Llamazares
authors.affiliation: Servicio de Oncología Radioterápica, Medicina Preventiva y Salud Pública, Complejo Asistencial Universitario de Salamanca, Salamanca, España.
authors.forename: V
authors.initials: V
authors.lastname: Macias
authors.affiliation: Servicio de Medicina Intensiva, Bioquímica, Cirugía y Epidemiología, Hospital Universitari Germans Trias i Pujol, Badalona, España.
authors.forename: J
authors.initials: J
authors.lastname: Roca
authors.affiliation: Servicio de Oncología Radioterápica, Medicina Preventiva y Salud Pública, Complejo Asistencial Universitario de Salamanca, Salamanca, España.
authors.forename: R
authors.initials: R
authors.lastname: Gonzalez-Celador
authors.affiliation: Servicio de Medicina Intensiva, Bioquímica, Cirugía y Epidemiología, Hospital Universitari Germans Trias i Pujol, Badalona, España.
authors.forename: É
authors.initials: É
authors.lastname: Amestoy
authors.affiliation: Servicio de Medicina Intensiva, Bioquímica, Cirugía y Epidemiología, Hospital Universitari Germans Trias i Pujol, Badalona, España.
authors.forename: J
authors.initials: J
authors.lastname: Klamburg
mesh_terms: D018806:APACHE; D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D000209:Acute-Phase Proteins / Q000652:urine*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood; D016638:Critical Illness; D003953:Diagnosis-Related Groups; D042241:Early Diagnosis; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay / Q000706:statistics & numerical data; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine
keywords: Acute renal failure; Critical illness; Fracaso renal agudo; Lipocalina asociada a la gelatinasa de neutrófilos; NGAL; Neutrophil gelatinase-associated lipocalin protein; Paciente crítico