title: Severe bone marrow suppression and hepatic dysfunction caused by piperacillin/tazobactam.
abstract: Piperacillin/tazobactam (TZP) is a commonly prescribed antibiotic. Here, we report a patient who developed agranulocytosis, thrombocytopenia, and severe hepatic dysfunction on day 17 while receiving TZP treatment for an intracranial infection. Bone marrow suppression and hepatic dysfunction are serious adverse effects that should be kept in mind when using long-term TZP.
authors.affiliation: From the Department of Pharmacy, 1st Hospital of Lanzhou University , Lanzhou , China.
authors.forename: Zhong-Fang
authors.initials: ZF
authors.lastname: He
authors.forename: Xin-An
authors.initials: XA
authors.lastname: Wu
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Wang
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D001853:Bone Marrow / Q000187:drug effects*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases; D008297:Male; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000008:administration & dosage / Q000009:adverse effects; D000077725:Piperacillin, Tazobactam Drug Combination; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin