title: Cycloaddition-based formal C-H alkynylation of isoindoles leading to the synthesis of air-stable fluorescent 1,3-dialkynylisoindoles.
abstract: Reaction of N-alkylisoindoles with (bromoethynyl)triisopropylsilane afforded 1,3-bis(triisopropylsilylethynyl) isoindoles in high yields. The formal C-H alkynylation proceeds under transition-metal-free conditions through [4 + 2] cycloaddition of the pyrrole ring of isoindole with bromoalkyne followed by ring-opening of the product.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan. ohmura@sbchem.kyoto-u.ac.jp
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Ohmura
authors.forename: Akihito
authors.initials: A
authors.lastname: Kijima
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Komori
authors.forename: Michinori
authors.initials: M
authors.lastname: Suginome