title: Clinical and follow up assessment of children in a program directed at the use of formulas for cow's milk protein allergy.
abstract: OBJECTIVE
  To determine clinical and follow up characteristics of children enrolled in a program to supply formulas for cow's milk allergy.
  
  
  METHODS
  descriptive study of a convenience sample composed of 214 children up to three years old, with clinical diagnosis of cow's milk allergy and/or standardized oral challenge, referred to the Program of Formulas for Cow's Milk Allergy at a Pediatric University Hospital, in Natal, Rio Grande do Norte, Brazil (2007/2009). Clinical-epidemiological data and formula indication (soy, protein hydrolysates or aminoacid formula) were assessed at the first consultation. Clinical response and nutritional evolution (Anthro-OMS2006) were observed after three months. Chi-square and paired t-test were used, being p<0.05 significant.
  
  
  RESULTS
  At the first consultation, mean age was 9.0±6.9 months. Digestive manifestations occurred in 81.8%; cutaneous ones, in 36.9% and respiratory ones in 23.8%. BMI Z-score <-2.0 standard deviations (SD) was found in 17.9% of children with isolated digestive symptoms, in 41.7% of those using cow's milk and in 8.7% of those using other formulas (p<0.01). The following formulas were used: soy in 61.2%, protein hydrolysates in 35.4% and aminoacids in 3.3%. Mean BMI Z-scores at initial consultation and after three months were, respectively: -0.24±1.47SD and 0.00±1.26SD (p=0.251), with soy formula, and -0.70±1.51SD and -0.14±1.36SD (p=0.322) with protein hydrolysates formula.
  
  
  CONCLUSIONS
  Digestive manifestations of cow's milk allergy were preponderant, and lead to greater nutritional impairment. The use of replacement formulas (isolated soy protein and protein hydrolysates) was important to maintain the nutritional status.
authors.affiliation: Faculdade de Medicina, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
authors.forename: Ana Laissa O
authors.initials: AL
authors.lastname: Aguiar
authors.forename: Clarissa Marques
authors.initials: CM
authors.lastname: Maranhão
authors.forename: Lívia Carvalho
authors.initials: LC
authors.lastname: Spinelli
authors.forename: Roberta Marinho
authors.initials: RM
authors.lastname: de Figueiredo
authors.forename: Jussara Melo C
authors.initials: JM
authors.lastname: Maia
authors.forename: Rosane Costa
authors.initials: RC
authors.lastname: Gomes
authors.forename: Hélcio de Sousa
authors.initials: Hde S
authors.lastname: Maranhão
mesh_terms: D000818:Animals; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D008297:Male; D008892:Milk / Q000009:adverse effects*; D016269:Milk Hypersensitivity / Q000175:diagnosis* / Q000178:diet therapy*