title: Mortalin is a prognostic factor of gastric cancer with normal p53 function.
abstract: BACKGROUND
  Mortalin is a heat-non-inducible member of the heat shock protein 70 family. Mortalin binds to p53 and prevents p53 from entering the nucleus. To understand the significance of mortalin in gastric cancer, we investigated the expression of mortalin and p53.
  
  
  METHODS
  Expression of mortalin and p53 was examined by immunohistochemical staining of 182 clinical samples of gastric cancer.
  
  
  RESULTS
  Mortalin-positive and aberrant p53-positive tumors were found in 75.2 and 49.5 % of cases, respectively. Mortalin-positive tumors were deeper in invasion and had more lymph node and liver metastases compared with mortalin-negative tumors (P < 0.01, P < 0.05, respectively). Mortalin-positive tumors had worse prognosis compared with mortalin-negative tumors (P = 0.035). Moreover, in tumors with normal p53 function, mortalin-positive tumors had worse prognosis compared with mortalin-negative tumors (P = 0.017).
  
  
  CONCLUSIONS
  Mortalin has a great impact on gastric cancer with normal p53. Therefore, mortalin is a target molecule for treatment of gastric cancer, as well as a promising prognostic factor, especially in tumors with normal p53.
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 821-8582, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ando
authors.forename: Eiji
authors.initials: E
authors.lastname: Oki
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ayae
authors.initials: A
authors.lastname: Ikawa-Yoshida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kitao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saeki
authors.forename: Yasue
authors.initials: Y
authors.lastname: Kimura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ida
authors.forename: Masaru
authors.initials: M
authors.lastname: Morita
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kusumoto
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D018840:HSP70 Heat-Shock Proteins; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C080352:mortalin