title: Novel pediatric delivery systems for second-line anti-tuberculosis medications: a case study.
abstract: Tens of thousands of children are sick with multidrug-resistant forms of tuberculosis (MDR-TB), but there are limited child-friendly delivery systems for second-line medications. This case study presents the development of a granular dosing spoon pediatric delivery system for para-aminosalicylic acid. This product is the first of its kind for MDR-TB and could serve as a model for the development of other urgently needed pediatric delivery systems for second-line anti-tuberculosis drugs.
authors.affiliation: Tuberculosis Research Unit, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA. jenniferfurin@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Furin
authors.forename: G
authors.initials: G
authors.lastname: Brigden
authors.forename: E
authors.initials: E
authors.lastname: Lessem
authors.forename: M C
authors.initials: MC
authors.lastname: Becerra
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D010131:Aminosalicylic Acid / Q000008:administration & dosage*; D000995:Antitubercular Agents / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D002648:Child; D004304:Dosage Forms; D016503:Drug Delivery Systems / Q000295:instrumentation; D004867:Equipment Design; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D004304:Dosage Forms; D010131:Aminosalicylic Acid