title: Resistance or adaptation? How susceptible is a 'glutaraldehyde-resistant' Pseudomonas aeruginosa isolate in the absence of selection pressure?
abstract: The activities of glutaraldehyde solution and an instrument disinfectant based on glutaraldehyde on a Pseudomonas aeruginosa isolate with reduced susceptibility to glutaraldehyde after the first and fifth passages were determined using three concentrations and temperatures. No significant difference was found between the first and fifth passages so phenotypic adaptation is unlikely.
authors.affiliation: Bode Science Center, Bode Chemie GmbH, Hamburg, Germany; Institute for Hygiene and Environmental Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany. guenter.kampf@bode-chemie.de
authors.forename: G
authors.initials: G
authors.lastname: Kampf
authors.forename: C
authors.initials: C
authors.lastname: Ostermeyer
authors.forename: S
authors.initials: S
authors.lastname: Tschudin-Sutter
authors.forename: A F
authors.initials: AF
authors.lastname: Widmer
mesh_terms: D004202:Disinfectants / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004361:Drug Tolerance; D005976:Glutaral / Q000494:pharmacology*; D006801:Humans; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D012692:Serial Passage; D013696:Temperature
chemical_list: D004202:Disinfectants; D005976:Glutaral
keywords: Adaptation; Glutaraldehyde; Pseudomonas aeruginosa; Resistance