title: [Application of 3.0T susceptibility weighted imaging in the diagnosis of hemorrhagic foci and the outcome prediction of rabbits with brain blast injury].
abstract: OBJECTIVE
  To investigate the value of susceptibility weighted imaging(SWI)in the diagnosis of hemorrhagic foci early after blast injury and its role in the outcome prediction.
  
  
  METHODS
  Totally 30 rabbits with blast-induced cerebral blast injury were used in this study. After routine CT/MRI and SWI scanning,quantified analysis was performed in regions of interest using post-processing technology. After dissecting the brains of the experimental rabbits,the cerebral histopathological changes were observed,and the results were compared with SWI findings.
  
  
  RESULTS
  In these 30 rabbits,22,102,221,and 738 hemorrhagic foci were detected by CT,T1WI,T2WI,and SWI,respectively. The number of cerebral microbleeds detected by SWI was significantly larger than those revealed by conventional T1WI and T2WI(Χ(2)=10.00,P<0.01). Furthermore,the SWI imaging displayed the punctiform(n=315,42.7%),lamellar(n=218,29.5%),slinar(n=205,27.8%)hypointense foci,with clear margin. The number of hemorrhagic foci detected by SWI was positively correlated with survival(r=-0.667,P<0.05).
  
  
  CONCLUSIONS
  SWI remarkably increases the detection rate of hemorrhagic foci(particularly microbleeds)in rabbits with cerebral blast injury. The number of cerebral microbleeds and location of foci are closely related with the outcomes and therefore may facilitate clinical managment.
authors.affiliation: School of Graduate Studies, Hebei North University, Zhangjiakou, Hebei,China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.forename: Guo-shi
authors.initials: GS
authors.lastname: Lv
authors.forename: Feng
authors.initials: F
authors.lastname: Han
authors.forename: Ke-ning
authors.initials: KN
authors.lastname: Xu
mesh_terms: D000818:Animals; D001753:Blast Injuries / Q000150:complications / Q000175:diagnosis*; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000175:diagnosis* / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011379:Prognosis; D011817:Rabbits