title: A chromatin remodeling complex regulates topoisomerase IIα function.
abstract: TOP2A-mediated DNA decatenation during mitosis requires the BAF subunits BRG1 and BAF250A.
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics* / Q000378:metabolism; D002843:Chromatin / Q000235:genetics; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D043171:Chromosomal Instability / Q000235:genetics; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D053595:Embryonic Stem Cells; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008938:Mitosis / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D000075223:Poly-ADP-Ribose Binding Proteins; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: C112476:ARID1A protein, human; D000951:Antigens, Neoplasm; D002843:Chromatin; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; D014157:Transcription Factors; C084108:SMARCA4 protein, human; D004265:DNA Helicases; D004250:DNA Topoisomerases, Type II; C000618811:TOP2A protein, human