title: PML, SUMOylation, and Senescence.
abstract: Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues. Here we review the reciprocal interactions between PML, senescence, and SUMOylation, notably in the context of cellular transformation.
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Hôpital St. Louis , Paris , France ; INSERM UMR 944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d'Hématologie, Hôpital St. Louis , Paris , France ; CNRS UMR 7212, Hôpital St. Louis , Paris , France.
authors.forename: Lisa
authors.initials: L
authors.lastname: Ivanschitz
authors.forename: Hugues
authors.initials: H
authors.lastname: De Thé
authors.forename: Morgane
authors.initials: M
authors.lastname: Le Bras
keywords: PML; SUMO; p53; senescence; tumor suppression