title: Three cases of concomitant intraductal papillary mucinous neoplasm and pancreatic neuroendocrine tumour.
abstract: BACKGROUND
  Intraductal papillary mucinous neoplasms (IPMNs) are uncommon tumours which can be associated with pancreatic and extrapancreatic malignancies. The association of IPMN and neuroendocrine tumours of the pancreas has been reported previously but is exceedingly rare.
  
  
  METHODS
  We report three cases of IPMN treated with total pancreatectomy/extended distal pancreatectomy. Histopathological analysis of the resected specimens revealed concomitant IPMN and neuroendocrine tumour. Two patients had adenocarcinoma as well.
  
  
  CONCLUSIONS
  The presence of an IPMN may place the entire pancreas at risk of developing other tumour types and vigilance during all stages of management is necessary to ensure optimal treatment.
authors.affiliation: Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre National Institute for Health Research Biomedical Research Unit, University of Nottingham, Queen's Medical Centre. Nottingham, United Kingdom.
authors.forename: Nilanjana
authors.initials: N
authors.lastname: Tewari
authors.forename: Abed M
authors.initials: AM
authors.lastname: Zaitoun
authors.forename: Daniel
authors.initials: D
authors.lastname: Lindsay
authors.forename: Areeg
authors.initials: A
authors.lastname: Abbas
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ilyas
authors.forename: Dileep N
authors.initials: DN
authors.lastname: Lobo
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D000368:Aged; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D010179:Pancreas / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D016708:Synaptophysin