title: To dream the impossible dream: universal influenza vaccination.
abstract: Year in and year out, influenza viruses exact a deadly and expensive toll on humanity. Current vaccines simply do not keep pace with viral immune evasion, providing partial protection, at best, among various age groups. A quantum leap in understanding the basic principles of the adaptive and innate immune responses to influenza viruses offers the opportunity to develop vaccines that forestall, and potentially ultimately defeat, influenza virus antigenic variation.
authors.affiliation: Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, United States. JYEWDELL@niaid.nih.gov
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Yewdell
mesh_terms: D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods*
chemical_list: D007252:Influenza Vaccines