title: Masseter function and skeletal malocclusion.
abstract: The aim of this work is to review the relationship between the function of the masseter muscle and the occurrence of malocclusions. An analysis was made of the masseter muscle samples from subjects who underwent mandibular osteotomies. The size and proportion of type-II fibers (fast) decreases as facial height increases. Patients with mandibular asymmetry have more type-II fibers on the side of their deviation. The insulin-like growth factor and myostatin are expressed differently depending on the sex and fiber diameter. These differences in the distribution of fiber types and gene expression of this growth factor may be involved in long-term postoperative stability and require additional investigations. Muscle strength and bone length are two genetically determined factors in facial growth. Myosin 1H (MYOH1) is associated with prognathia in Caucasians. As future objectives, we propose to characterize genetic variations using "Genome Wide Association Studies" data and their relationships with malocclusions.
authors.affiliation: Department of Orthodontics, Temple University, Philadelphia, PA 19104, USA. jsciote@dental.temple.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Sciote
authors.forename: G
authors.initials: G
authors.lastname: Raoul
authors.forename: J
authors.initials: J
authors.lastname: Ferri
authors.forename: J
authors.initials: J
authors.lastname: Close
authors.forename: M J
authors.initials: MJ
authors.lastname: Horton
authors.forename: A
authors.initials: A
authors.lastname: Rowlerson
mesh_terms: D002508:Cephalometry; D020022:Genetic Predisposition to Disease; D006801:Humans; D007569:Jaw Abnormalities / Q000235:genetics / Q000534:rehabilitation / Q000601:surgery; D008310:Malocclusion / Q000209:etiology* / Q000503:physiopathology*; D008406:Masseter Muscle / Q000166:cytology / Q000502:physiology*; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000502:physiology