title: Resveratrol in metabolic health: an overview of the current evidence and perspectives.
abstract: In the search for novel preventive and therapeutic modalities in the management of metabolic diseases and obesity, resveratrol has attracted great attention over the past decades. Preclinical trials suggest that resveratrol mimics the metabolic effects of calorie restriction (CR) via activation of silent mating type information regulation 2 homolog 1 (SIRT1). In experimental animals, this potential translates into prevention or improvement of glucose metabolism, anti-inflammation, cancer, and nonalcoholic fatty liver disease. Moreover, and in accordance with CR, supplementation with resveratrol promotes longevity in several primitive species and protects against diet-induced metabolic abnormalities in rodents. Despite the substantial preclinical evidence, human clinical data are very scarce, and even though the compound is widely distributed as an over-the-counter human nutritional supplement, its therapeutic rationale has not been well characterized. In this review, we provide a brief overview of the field and discuss the future scientific directions of resveratrol research.
authors.affiliation: Department of Endocrinology and Internal Medicine, MEA, Aarhus University Hospital and Institute of Clinical Medicine, Aarhus University, Denmark. mmp@ki.au.dk
authors.forename: Morten Møller
authors.initials: MM
authors.lastname: Poulsen
authors.forename: Jens Otto Lunde
authors.initials: JO
authors.lastname: Jørgensen
authors.forename: Niels
authors.initials: N
authors.lastname: Jessen
authors.forename: Bjørn
authors.initials: B
authors.lastname: Richelsen
authors.forename: Steen Bønløkke
authors.initials: SB
authors.lastname: Pedersen
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D002986:Clinical Trials as Topic / Q000379:methods; D019587:Dietary Supplements; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000378:metabolism*; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000378:metabolism; D013267:Stilbenes / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D013267:Stilbenes; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077185:Resveratrol
keywords: clinical trials; in vitro; in vivo; metabolism; resveratrol