title: C-H cycloamination of N-aryl-2-aminopyridines and N-arylamidines catalyzed by an in situ generated hypervalent iodine(III) reagent.
abstract: A metal-free synthesis of diversified pyrido[1,2-a]benzimidazoles and 1H-benzo[d]imidazoles from N-aryl-2-aminopyridines and N-arylamidines has been developed. The C-H cycloamination reaction was catalyzed by hypervalent iodine(III) species generated in situ from iodobenzene (catalytic) and peracetic acid (stoichiometric). The reaction proceeded smoothly at ambient temperature to provide the corresponding N-heterocycles in good to excellent yields.
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.
authors.forename: Yimiao
authors.initials: Y
authors.lastname: He
authors.forename: Jinbo
authors.initials: J
authors.lastname: Huang
authors.forename: Dongdong
authors.initials: D
authors.lastname: Liang
authors.forename: Lanying
authors.initials: L
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D000578:Amidines / Q000737:chemistry*; D000631:Aminopyridines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000578:Amidines; D000631:Aminopyridines; D007093:Imidazoles; D007455:Iodine