title: The B1-cell subpopulation is diminished in patients with relapsing-remitting multiple sclerosis.
abstract: B cell subsets in newly diagnosed untreated, relapsing-remitting multiple sclerosis (MS) patients were examined. The fraction of CD20(+) B cells was significantly increased in MS. Among subsets of B cells, MS patients had increased frequency of naïve cells, but reduced frequency of memory and B1 cells. The frequencies of B1 cells were inversely correlated with the time since last attack. B1 cells resembled the phenotype of either lymphocytes (CD11b(-) B1 cells) or monocytes (CD11b(+) B1 cells) and a small fraction of cells was CD3(+)CD20(+) by confocal microscopy.
authors.affiliation: Department of Neurology, Aarhus University Hospital, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
authors.forename: Caroline
authors.initials: C
authors.lastname: Tørring
authors.forename: Charlotte Christie
authors.initials: CC
authors.lastname: Petersen
authors.forename: Lasse
authors.initials: L
authors.lastname: Bjerg
authors.forename: Emil
authors.initials: E
authors.lastname: Kofod-Olsen
authors.forename: Thor
authors.initials: T
authors.lastname: Petersen
authors.forename: Per
authors.initials: P
authors.lastname: Höllsberg
mesh_terms: D000328:Adult; D018951:Antigens, CD20 / Q000096:biosynthesis; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D017252:CD3 Complex / Q000096:biosynthesis; D015536:Down-Regulation / Q000276:immunology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D018655:Lymphocyte Count; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D015854:Up-Regulation / Q000276:immunology
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex
keywords: B cells; B-cell-depleting antibodies; CD3(+)CD20(+) cells; Human B1 cells; Relapsing–remitting multiple sclerosis