title: Primary inflammatory malignant fibrous histiocytoma of the breast: a case report of an unusual variant and review of the literature.
abstract: Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of adults, but its presence in the breast is rare. We report a case of primary inflammatory MFH in a 72-year-old Caucasian female with no previous medical history and no prior radiation exposure. She presented with a palpable mass that was suspicious for malignancy on mammography. Histologic evaluation of the core needle biopsy revealed sheets of large, pleomorphic neoplastic cells within a dense background of acute and chronic inflammatory cells. The neoplastic cells exhibited a moderate to abundant amount of finely vacuolated cytoplasm and atypical nuclei with vesicular nuclear chromatin and prominent nucleoli. Mitotic activity was readily identified, and foci of necrosis were noted. The neoplastic cells were immunoreactive with CD68, alpha 1-antitrypsin, alpha 1-antichymotrypsin, and vimentin. The diagnosis of MFH was rendered after thorough microscopic examination of the entire mass following mastectomy. MFH of the breast is a diagnosis of exclusion. The definitive treatment of MFH is surgical, either with wide local excision or total mastectomy. The roles of sentinel lymph node biopsy, axillary lymph node dissection, chemotherapy, and radiation have yet to be definitively clarified. The prognosis of MFH of the breast is generally poor.
authors.affiliation: Department of Pathology, St. John Hospital & Medical Center, Detroit, MI, USA. randy.tashjian.md@gmail.com
authors.forename: Randy
authors.initials: R
authors.lastname: Tashjian
authors.forename: Syed M
authors.initials: SM
authors.lastname: Gilani
authors.forename: Jeffery
authors.initials: J
authors.lastname: Falk
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kelly
authors.forename: Daniel
authors.initials: D
authors.lastname: Ockner
authors.forename: Robert
authors.initials: R
authors.lastname: Danforth
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D062005:Biopsy, Large-Core Needle; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008327:Mammography; D008408:Mastectomy; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Alpha 1-antitrypsin; Breast; CD68; Malignant fibrous histiocytoma; Sarcoma