title: Enhanced efficacy and broadening of antibacterial action of drugs via the use of capped mesoporous nanoparticles.
abstract: Bug busters: A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε-poly-L-lysine (ε-PL) was prepared and its interaction with different Gram-negative bacteria studied. A remarkable improvement in the efficacy of the antimicrobial drug ε-PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.
authors.affiliation: Centro de Reconocimiento Molecular y Desarrollo Tecnológico, Departamento de Química, Universidad Politécnica de Valencia, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: Núria
authors.initials: N
authors.lastname: Mas
authors.forename: Irene
authors.initials: I
authors.lastname: Galiana
authors.forename: Laura
authors.initials: L
authors.lastname: Mondragón
authors.forename: Elena
authors.initials: E
authors.lastname: Aznar
authors.forename: Estela
authors.initials: E
authors.lastname: Climent
authors.forename: Nuria
authors.initials: N
authors.lastname: Cabedo
authors.forename: Félix
authors.initials: F
authors.lastname: Sancenón
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Murguía
authors.forename: Ramón
authors.initials: R
authors.lastname: Martínez-Máñez
authors.forename: María D
authors.initials: MD
authors.lastname: Marcos
authors.forename: Pedro
authors.initials: P
authors.lastname: Amorós
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D011107:Polylysine / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D014640:Vancomycin / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; C509968:MCM-41; D011107:Polylysine; D014640:Vancomycin; D012822:Silicon Dioxide
keywords: gated materials; mesoporous materials; nanoparticles; vancomycin; ε-poly-L-lysine