title: A ratiometric fluorescent dye for the detection of glutathione in live cells and liver cancer tissue.
abstract: A novel ratiometric biothiol probe Glutathione Green was developed. It allows quantitative measurement of glutathione in cell extracts and direct visualization of changes in glutathione levels in live cells. Remarkably, this is the first reported biothiol probe which can detect the carcinoma region of liver tissue based on the differences in the glutathione level.
authors.affiliation: Department of Chemistry and MedChem Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Duanting
authors.initials: D
authors.lastname: Zhai
authors.forename: Sung-Chan
authors.initials: SC
authors.lastname: Lee
authors.forename: Seong-Wook
authors.initials: SW
authors.lastname: Yun
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005978:Glutathione / Q000032:analysis*; D006367:HeLa Cells; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008856:Microscopy, Fluorescence; D051381:Rats
chemical_list: D001896:Boron Compounds; D005456:Fluorescent Dyes; C586256:glutathione green; D005978:Glutathione