title: Emergence of Pseudomonas aeruginosa with KPC-type carbapenemase in a teaching hospital: an 8-year study.
abstract: An outbreak of Klebsiella pneumoniae carbapenamase (KPC)-producing K. pneumoniae occurred at our institution. Multiresistant Pseudomonas aeruginosa could have acquired this transmissible resistance mechanism, going unnoticed because its phenotypic detection in this species is difficult. We compared P. aeruginosa isolates obtained before and after the KPC-producing K. pneumoniae outbreak. No bla(KPC) genes were detected in the isolates obtained before the outbreak, whereas 33/76 (43%) of the isolates obtained after the outbreak harboured the bla(KPC) gene. P. aeruginosa may thus become a reservoir of this transmissible resistance mechanism. It is very important to understand the epidemiology of these multiresistant isolates, in order to achieve early implementation of adequate control measures to contain and reduce their dissemination in the hospital environment.
authors.affiliation: Laboratory of Bacteriology, Mycology and Parasitology, Center of Medical Education and Clinical Research 'Norberto Quirno' (CEMIC), Buenos Aires, Argentina.
authors.forename: Dolores García
authors.initials: DG
authors.lastname: Ramírez
authors.affiliation: Laboratory of Bacteriology, Mycology and Parasitology, Center of Medical Education and Clinical Research 'Norberto Quirno' (CEMIC), Buenos Aires, Argentina.
authors.forename: Federico
authors.initials: F
authors.lastname: Nicola
authors.affiliation: Laboratory of Bacteriology, Mycology and Parasitology, Center of Medical Education and Clinical Research 'Norberto Quirno' (CEMIC), Buenos Aires, Argentina.
authors.forename: Soledad
authors.initials: S
authors.lastname: Zarate
authors.affiliation: Laboratory of Bacteriology, Mycology and Parasitology, Center of Medical Education and Clinical Research 'Norberto Quirno' (CEMIC), Buenos Aires, Argentina.
authors.forename: Silvia
authors.initials: S
authors.lastname: Relloso
authors.affiliation: Laboratory of Bacteriology, Mycology and Parasitology, Center of Medical Education and Clinical Research 'Norberto Quirno' (CEMIC), Buenos Aires, Argentina.
authors.forename: Jorgelina
authors.initials: J
authors.lastname: Smayevsky
authors.affiliation: Laboratory of Bacteriology, Mycology and Parasitology, Center of Medical Education and Clinical Research 'Norberto Quirno' (CEMIC), Buenos Aires, Argentina.
authors.forename: Sonia
authors.initials: S
authors.lastname: Arduino
mesh_terms: D001118:Argentina / Q000453:epidemiology; D001426:Bacterial Proteins / Q000235:genetics*; D004196:Disease Outbreaks; D022761:Gene Transfer, Horizontal; D006784:Hospitals, Teaching; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification*; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase