title: Cytokine gene polymorphisms and Alzheimer's disease in Brazil.
abstract: BACKGROUND
  Single-nucleotide polymorphisms in genes encoding immunological mediators can affect the biological activity of these molecules by regulating transcription, translation, or secretion, modulating the genetic risk of inflammatory damage in Alzheimer's disease (AD). Nonetheless, the Brazilian contingent is highly admixed, and few association trials performed herein with AD patients have considered genetic ancestry estimates as co-variables when investigating markers for this complex trait.
  
  
  METHODS
  We analyzed polymorphisms in 10 inflammatory genes and compared the genotype distribution across outpatients with late-onset AD and noncognitively impaired subjects from Midwest Brazil under a strict criterion, and controlling for ancestry heritage and ApoE genotype.
  
  
  RESULTS
  Our findings show an almost 40% lower chance of AD (p = 0.004) among homozygotes of the IL10 -1082A allele (rs1800896). Dichotomization to ApoE and mean ancestry levels did not affect protection, except among those with greater European or minor African heritage.
  
  
  CONCLUSIONS
  The IL10 locus seems to affect the onset of AD in a context sensitive to the genetic ancestry of Brazilian older adults.
authors.affiliation: Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília, Brasília, Brasil.
authors.forename: Clayton F
authors.initials: CF
authors.lastname: Moraes
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Benedet
authors.forename: Vinícius C
authors.initials: VC
authors.lastname: Souza
authors.forename: Túlio C
authors.initials: TC
authors.lastname: Lins
authors.forename: Einstein F
authors.initials: EF
authors.lastname: Camargos
authors.forename: Janeth O S
authors.initials: JO
authors.lastname: Naves
authors.forename: Ciro J
authors.initials: CJ
authors.lastname: Brito
authors.forename: Cláudio
authors.initials: C
authors.lastname: Córdova
authors.forename: Rinaldo W
authors.initials: RW
authors.lastname: Pereira
authors.forename: Otávio T
authors.initials: OT
authors.lastname: Nóbrega
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001938:Brazil; D016207:Cytokines / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012189:Retrospective Studies
chemical_list: D016207:Cytokines