title: Stannous fluoride dentifrices.
abstract: Stannous fluoride has a long history of use in the improvement of oral health, and was the fluoride source first proven to provide anti-caries benefits when delivered from a dentrifrice formulation. This paper provides an account of the early use of stannous fluoride, primarily for an anti-caries benefit, and the subsequent attempts to formulate stannous fluoride into stable formulations where additional benefits of the stannous cation can be realized.
authors.affiliation: GlaxoSmithKline Consumer Healthcare, St Georges Avenue, Weybridge, KT 13 ODE United Kingdom. stephen.a.makin@gsk.com
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Makin
mesh_terms: D002131:Calcium Pyrophosphate / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control; D003802:Dentifrices / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004338:Drug Combinations; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D010710:Phosphates / Q000627:therapeutic use; D011122:Polyphosphates / Q000627:therapeutic use; D014002:Tin Fluorides / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D014075:Tooth Discoloration / Q000517:prevention & control
chemical_list: D003802:Dentifrices; D004338:Drug Combinations; D010710:Phosphates; D011122:Polyphosphates; D014002:Tin Fluorides; C012980:fluorophosphate; C005692:triphosphoric acid; D005459:Fluorides; D002131:Calcium Pyrophosphate