title: Novel soy germ pasta enriched in isoflavones ameliorates gastroparesis in type 2 diabetes: a pilot study.
abstract: OBJECTIVE
  To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis.
  
  
  METHODS
  This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1/2) was measured using the [(13)C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load.
  
  
  RESULTS
  Soy germ pasta significantly accelerated the t1/2 in these patients (161.2 ± 17.5 min at baseline vs. 112.6 ± 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 ± 24.2 vs. 156.2 ± 27.4 min), without affecting glucose or insulin concentrations.
  
  
  CONCLUSIONS
  These findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy.
authors.affiliation: Corresponding author: Kenneth D.R. Setchell, kenneth.setchell@cchmc.org.
authors.forename: Kenneth D R
authors.initials: KD
authors.lastname: Setchell
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Nardi
authors.forename: Pier-Maria
authors.initials: PM
authors.lastname: Battezzati
authors.forename: Stefania
authors.initials: S
authors.lastname: Asciutti
authors.forename: Danilo
authors.initials: D
authors.lastname: Castellani
authors.forename: Gabriele
authors.initials: G
authors.lastname: Perriello
authors.forename: Carlo
authors.initials: C
authors.lastname: Clerici
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000178:diet therapy*; D004311:Double-Blind Method; D005260:Female; D005527:Food, Fortified; D005746:Gastric Emptying / Q000187:drug effects*; D018589:Gastroparesis / Q000178:diet therapy* / Q000209:etiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007529:Isoflavones / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D045730:Soy Foods
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007529:Isoflavones