title: The clinical value of 18F-FDG PET/CT in the evaluation of bone metastases undetermined origin.
abstract: OBJECTIVE
  To evaluate the clinical value of (18)F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) in detection of primary lesions of bone metastases.
  
  
  METHODS
  The PET/CT scans of 77 patients with bone metastases undetermined origin were retrospectively reviewed. The results of clinical information were collected.
  
  
  RESULTS
  Forty-four suspected primary tumors were found on the PET/CT images in 77 patients of bone metastases, including 40 patients with the primary tumor confirmed, and 4 patients false-positive. In 37 patients, no primary lesions were detected, including one patient false-negative (signet-ring cell carcinoma). The sensitivity, specificity, and accuracy was 97.6%, 88.9%,and 93.5% respectively. The primary lesions of 51.9% patients could be diagnosed by PET/CT.
  
  
  CONCLUSIONS
  PET/CT is helpful in detecting the primary lesions of bone metastases.
authors.affiliation: Department of Nuclear Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Hu
authors.forename: Xiangming
authors.initials: X
authors.lastname: Zhang
authors.forename: Biao
authors.initials: B
authors.lastname: Li
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-FDG; Bone metastases; PET/CT; Primary lesions