title: Multicomponent synthesis of antibacterial dihydropyridin and dihydropyran embelin derivatives.
abstract: A series of dihydropyran and dihydropyridin embelin derivatives were synthesized through a novel and straightforward one-pot protocol based on a three-component reaction with embelin, aldehydes, and cyclic enaminones as synthetic imputs. The type of substituent on the nitrogen atom of the β-enaminone is key to obtain nitrogenated or oxygenated rings. The obtained compounds were active against Gram-positive bacteria, including multiresistant Staphylococcus aureus clinical isolates.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez, 38206 La Laguna, Tenerife, Spain.
authors.forename: Rosalyn
authors.initials: R
authors.lastname: Peña
authors.forename: Sandra
authors.initials: S
authors.lastname: Jiménez-Alonso
authors.forename: Gabriela
authors.initials: G
authors.lastname: Feresin
authors.forename: Alejandro
authors.initials: A
authors.lastname: Tapia
authors.forename: Sebastián
authors.initials: S
authors.lastname: Méndez-Alvarez
authors.forename: Félix
authors.initials: F
authors.lastname: Machín
authors.forename: Ángel G
authors.initials: ÁG
authors.lastname: Ravelo
authors.forename: Ana
authors.initials: A
authors.lastname: Estévez-Braun
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000737:chemistry; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D004095:Dihydropyridines; D011714:Pyrans; C038806:1,4-dihydropyridine; C010945:embelin