title: Updated physiology and pathophysiology of CSF circulation--the pulsatile vector theory.
abstract: BACKGROUND
  Hydrocephalus is still a not well-understood diagnostic and a therapeutic dilemma because of the lack of sufficient and comprehensive model of cerebrospinal fluid circulation and pathological alterations.
  
  
  CONCLUSIONS
  Based on current studies, reviews, and knowledge of cerebrospinal fluid dynamics, brain water dynamics, intracranial pressure, and cerebral perfusion physiology, a new concept is deducted that can describe normal and pathological changes of cerebrospinal fluid circulation and pathophysiology of idiopathic intracranial hypertension.
authors.affiliation: Department of Neurosurgery, Pediatric Neurosurgery, University Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany, preuss@neurosurgeon.ch.
authors.forename: M
authors.initials: M
authors.lastname: Preuss
authors.forename: K-T
authors.initials: KT
authors.lastname: Hoffmann
authors.forename: M
authors.initials: M
authors.lastname: Reiss-Zimmermann
authors.forename: W
authors.initials: W
authors.lastname: Hirsch
authors.forename: A
authors.initials: A
authors.lastname: Merkenschlager
authors.forename: J
authors.initials: J
authors.lastname: Meixensberger
authors.forename: M
authors.initials: M
authors.lastname: Dengl
mesh_terms: D001921:Brain / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology*; D011673:Pulsatile Flow / Q000502:physiology