title: A 100-channel hermetically sealed implantable device for chronic wireless neurosensing applications.
abstract: A 100-channel fully implantable wireless broadband neural recording system was developed. It features 100 parallel broadband (0.1 Hz-7.8 kHz) neural recording channels, a medical grade 200 mAh Li-ion battery recharged inductively at 150 kHz , and data telemetry using 3.2 GHz to 3.8 GHz FSK modulated wireless link for 48 Mbps Manchester encoded data. All active electronics are hermetically sealed in a titanium enclosure with a sapphire window for electromagnetic transparency. A custom, high-density configuration of 100 individual hermetic feedthrough pins enable connection to an intracortical neural recording microelectrode array. A 100 MHz bandwidth custom receiver was built to remotely receive the FSK signal and achieved -77.7 dBm sensitivity with 10(-8) BER at 48 Mbps data rate. ESD testing on all the electronic inputs and outputs has proven that the implantable device satisfies the HBM Class-1B ESD Standard. In addition, the evaluation of the worst-case charge density delivered to the tissue from each I/O pin verifies the patient safety of the device in the event of failure. Finally, the functionality and reliability of the complete device has been tested on-bench and further validated chronically in ongoing freely moving swine and monkey animal trials for more than one year to date.
authors.affiliation: School of Engineering, Brown University, Providence, RI 02912, USA. ming_yin@brown.edu
authors.forename: Ming
authors.initials: M
authors.lastname: Yin
authors.forename: David A
authors.initials: DA
authors.lastname: Borton
authors.forename: Juan
authors.initials: J
authors.lastname: Aceros
authors.forename: William R
authors.initials: WR
authors.lastname: Patterson
authors.forename: Arto V
authors.initials: AV
authors.lastname: Nurmikko
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry; D000669:Amplifiers, Electronic; D000818:Animals; D001698:Biomedical Engineering / Q000295:instrumentation; D060733:Electromagnetic Radiation; D004581:Electronics; D004867:Equipment Design; D000882:Haplorhini; D058542:Implantable Neurostimulators; D008839:Microelectrodes; D058117:Neural Prostheses; D012815:Signal Processing, Computer-Assisted; D013552:Swine; D013686:Telemetry / Q000379:methods; D014025:Titanium / Q000737:chemistry; D059015:Wireless Technology
chemical_list: D014025:Titanium; D000537:Aluminum Oxide