title: Treatment of mercury vapor toxicity by combining deferasirox and deferiprone in rats.
abstract: The hypothesis that combination of deferasirox and deferiprone chelators might be more efficient as combined therapy than single therapy in removing mercury from the body was considered. Male Wistar rats were exposed to mercury vapor for 2 weeks. After mercury administration some abnormal clinical signs such as red staining around the eyes, greenish mottling on the liver, weakness, loss of hair and weight, were observed in animals. Chelators were given orally after mercury vapor application for 2 weeks. Mercury toxicity symptoms in rats decreased after drug administration. After chelation therapy, these rats were anesthetized with ether vapor and immobilized by cervical dislocation and then their heart, liver, kidneys, intestine, spleen and testicles were sampled for determination of mercury and iron concentration. The combined chelation therapy results showed that these chelators are able to remove mercury from the body and toxicity symptoms decreased.
authors.affiliation: Department of Chemistry, Shahid Bahonar University of Kerman, 22 Bahman Blvd, Kerman, P.O. Box 76961, Iran, mzh_iranmanesh@yahoo.com.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Iranmanesh
authors.forename: S Jamil A
authors.initials: SJ
authors.lastname: Fatemi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Golbafan
authors.forename: Faezeh Dahooee
authors.initials: FD
authors.lastname: Balooch
mesh_terms: D000818:Animals; D001565:Benzoates / Q000008:administration & dosage / Q000627:therapeutic use*; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077588:Deferasirox; D000077543:Deferiprone; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D008297:Male; D008628:Mercury / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D015394:Molecular Structure; D011728:Pyridones / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D014835:Volatilization
chemical_list: D001565:Benzoates; D002614:Chelating Agents; D011728:Pyridones; D014230:Triazoles; D000077543:Deferiprone; D008628:Mercury; D000077588:Deferasirox