title: MRI-visualized, dual-targeting, combined tumor therapy using magnetic graphene-based mesoporous silica.
abstract: Targeting peptide-modified magnetic graphene-based mesoporous silica (MGMSPI) are synthesized, characterized, and developed as a multifunctional theranostic platform. This system exhibits many merits, such as biocompatibility, high near-infrared photothermal heating, facile magnetic separation, large T2 relaxation rates (r2), and a high doxorubicin (DOX) loading capacity. In vitro and in vivo results demonstrate that DOX-loaded MGMSPI (MGMSPID) can integrate magnetic resonance imaging, dual-targeting recognition (magnetic targeting and receptor-mediated active targeting), and chemo-photothermal therapy into a single system for a visualized-synergistic therapy of glioma. In addition, it is observed that the MGMSPID system has heat-stimulated, pH-responsive, sustained release properties. All of these characteristics would provide a robust multifunctional theranostic platform for visualized glioma therapy.
authors.affiliation: Department of Chemistry, Fudan University, Shanghai 200433, PR China; Center of Analysis and Measurement, Fudan University, Shanghai 200433, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Rongqin
authors.initials: R
authors.lastname: Huang
authors.forename: Guohai
authors.initials: G
authors.lastname: Liang
authors.forename: Zhengyong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Shaoning
authors.initials: S
authors.lastname: Yu
authors.forename: Jilie
authors.initials: J
authors.lastname: Kong
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry / Q000627:therapeutic use; D005910:Glioma / Q000188:drug therapy*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D012822:Silicon Dioxide; D006108:Graphite; D004317:Doxorubicin
keywords: MRI; combined therapies; dual targeting; graphene; mesoporous silica; theranostics