title: Clinical pregnancy after uterus transplantation.
abstract: OBJECTIVE
  To present the first clinical pregnancy after uterus transplantation.
  
  
  METHODS
  Case study.
  
  
  METHODS
  Tertiary center.
  
  
  METHODS
  A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation.
  
  
  METHODS
  Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos.
  
  
  METHODS
  Implantation of embryo in an allografted human uterus.
  
  
  RESULTS
  The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization.
  
  
  CONCLUSIONS
  We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.
authors.affiliation: Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey. Electronic address: meakar@akdeniz.edu.tr.
authors.forename: Munire
authors.initials: M
authors.lastname: Erman Akar
authors.forename: Omer
authors.initials: O
authors.lastname: Ozkan
authors.forename: Batu
authors.initials: B
authors.lastname: Aydinuraz
authors.forename: Kerem
authors.initials: K
authors.lastname: Dirican
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cincik
authors.forename: Inanc
authors.initials: I
authors.lastname: Mendilcioglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Simsek
authors.forename: Filiz
authors.initials: F
authors.lastname: Gunseren
authors.forename: Huseyin
authors.initials: H
authors.lastname: Kocak
authors.forename: Akif
authors.initials: A
authors.lastname: Ciftcioglu
authors.forename: Omer
authors.initials: O
authors.lastname: Gecici
authors.forename: Ozlenen
authors.initials: O
authors.lastname: Ozkan
mesh_terms: D058489:46, XX Disorders of Sex Development / Q000503:physiopathology / Q000601:surgery*; D000022:Abortion, Spontaneous / Q000209:etiology; D000013:Congenital Abnormalities / Q000503:physiopathology / Q000601:surgery*; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005298:Fertility; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro; D005865:Gestational Age; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology / Q000601:surgery*; D009095:Mullerian Ducts / Q000002:abnormalities* / Q000503:physiopathology / Q000601:surgery; D011247:Pregnancy; D016896:Treatment Outcome; D014599:Uterus / Q000002:abnormalities / Q000503:physiopathology / Q000601:surgery*; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female
keywords: Uterus transplantation; clinical pregnancy; uterine factor infertility