title: Synthesis and biological response of casein-based silica nano-composite film for drug delivery system.
abstract: Casein possesses many interesting properties that make it a good candidate for conventional and novel drug delivery systems. In this study, casein-based silica nano-composite was prepared via double in situ method, and the as-prepared latex particles were evaluated in terms of their morphology and size through transmission electron microscopy (TEM). The film morphology was investigated by scanning electron microscopy (SEM) and energy dispersive X-ray (EDX), and the mechanical property and response behavior of the films as a function of silica content were discussed. Ibuprofen was used as the model drug. The drug load and release properties were studied by solid-state nuclear magnetic resonance (solid-state NMR), Fourier transform infrared (FT-IR), SEM and in vitro test. The composite latex particle showed a stable core-shell structure, and the film exhibited a regular surface with even SiO2 distribution. The drug load efficiency of the composite films increased with adding silica because of the adsorption of the drugs on the silica. In an acidic release medium, the ibuprofen-loaded composite showed a slower drug release dependent on the silica content. These behaviors were most likely due to the reduced diffusion rate of the drug through the composite microsphere, which resulted from the interaction between the silica and the drug.
authors.affiliation: College of Resources and Environment, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi Province, PR China. Electronic address: majz@sust.edu.cn.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Ma
authors.affiliation: College of Resources and Environment, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi Province, PR China.
authors.forename: Qunna
authors.initials: Q
authors.lastname: Xu
authors.affiliation: College of Resources and Environment, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi Province, PR China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhou
authors.affiliation: College of Foreign Languages and Communications, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi Province, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Spectrum and State Key Laboratory of Atomic and Molecular, Wuhan Magnetic Resonance Center, Chinese Academy of Sciences, Wuhan Institute of Physics and Mathematics, Wuhan 430071, Hubei Province, PR China.
authors.forename: Limin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Spectrum and State Key Laboratory of Atomic and Molecular, Wuhan Magnetic Resonance Center, Chinese Academy of Sciences, Wuhan Institute of Physics and Mathematics, Wuhan 430071, Hubei Province, PR China.
authors.forename: Huiru
authors.initials: H
authors.lastname: Tang
authors.affiliation: College of Resources and Environment, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi Province, PR China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Chen
mesh_terms: D002364:Caseins / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000494:pharmacology*; D008863:Microspheres; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012822:Silicon Dioxide / Q000138:chemical synthesis* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D002364:Caseins; D012822:Silicon Dioxide; D007052:Ibuprofen
keywords: Biocompatibility; Composite; Drug delivery; In vitro test; Microsphere; Microstructure