title: Urine S100 BB and A1B dimers are valuable predictors of adverse outcome in full-term asphyxiated infants.
abstract: OBJECTIVE
  To investigate whether S100A1B and BB dimers are predictors of early perinatal death in newborns with perinatal asphyxia (PA).
  
  
  METHODS
  The study compared 38 full-term newborns with PA [neonatal death n = 11; hypoxic ischaemic encephalopathy (HIE): n = 27] with a control group of 38 healthy infants. Clinical and laboratory parameters were recorded at eight time points and urine collected for S100B assessment. Multivariate analysis was performed in order to analyse the influence of various clinical parameters on the occurrence of neonatal death.
  
  
  RESULTS
  A1B and BB in PA nonsurvivor infants were significantly higher (p < 0.001) than in controls at all monitoring time points. BB at first void (cut-off>42 ng/L) was the best predictor of early neonatal death (p < 0.05) of all the clinical and laboratory parameters studied.
  
  
  CONCLUSIONS
  These results suggest that S100s are valuable predictors of adverse outcome in PA infants. It is also suggested that these biomarkers be used in daily clinical practice, due to their low cost and stress, reproducibility and the possibility of longitudinal monitoring.
authors.affiliation: Department of Neonatology, G Gaslini Children's University Hospital, Genoa, Italy.
authors.forename: Francesco M
authors.initials: FM
authors.lastname: Risso
authors.forename: Laura D
authors.initials: LD
authors.lastname: Serpero
authors.forename: Luc J I
authors.initials: LJ
authors.lastname: Zimmermann
authors.forename: Antonio W D
authors.initials: AW
authors.lastname: Gavilanes
authors.forename: Rosanna
authors.initials: R
authors.lastname: Frulio
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Michetti
authors.forename: Pasquale
authors.initials: P
authors.lastname: Florio
authors.forename: Moataza
authors.initials: M
authors.lastname: Bashir
authors.forename: Iman
authors.initials: I
authors.lastname: Iskander
authors.forename: Hala
authors.initials: H
authors.lastname: Mufeed
authors.forename: Hanna
authors.initials: H
authors.lastname: Aboulgar
authors.forename: Diego
authors.initials: D
authors.lastname: Gazzolo
mesh_terms: D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy / Q000652:urine; D015415:Biomarkers / Q000737:chemistry / Q000652:urine; D016022:Case-Control Studies; D003661:Decision Support Techniques; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy / Q000652:urine; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care; D064568:S100 Calcium Binding Protein beta Subunit / Q000737:chemistry / Q000652:urine*; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human
keywords: Asphyxia; Hypoxic ischaemic encephalopathy; Neonatal death; S100A1B; S100BB