title: The DREAM complex: master coordinator of cell cycle-dependent gene expression.
abstract: The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.
authors.affiliation: Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560065, India.
authors.forename: Subhashini
authors.initials: S
authors.lastname: Sadasivam
authors.forename: James A
authors.initials: JA
authors.lastname: DeCaprio
mesh_terms: D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000502:physiology*; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D016160:Retinoblastoma Protein / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D016160:Retinoblastoma Protein; D014157:Transcription Factors