title: [Clinical value of hCG ratio of blood in peritoneal cavity versus venous blood in diagnosis of ectopic pregnancy].
abstract: OBJECTIVE
  To study the value of hCG ratio of blood in peritoneal cavity versus venous blood (RPhCG/VhCG) in diagnosis of early ectopic pregnancy (EP).
  
  
  METHODS
  From Mar. 2009 to Oct. 2012, 268 cases with EP (EP group) and 53 women with intrauterine pregnancy with haemoperitoneum (hIUP) (hIUP group) from International Peace Maternity and Child Health Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 6th People Hospital and Shanghai Jiangwan Hospital were enrolled in this prospective study. The HCG of all subjective were measured in blood in peritonea cavity and venous blood, then calculate the ratio of RPhCG/VhCG. Scatter point analysis and ROC were used to differentiate EP, determine threshold of hIUP and evaluate the sensitivity, specificity and accuracy in diagnosis EP preoperatively.
  
  
  RESULTS
  The mean RPhCG/VhCG of EP group was 4.35, which was significantly higher than 0.81 in hIUP group (P < 0.01). Scatter point analysis showed that the threshold value of RPhCG/VhCG between ectopic pregnancy and hIUP was 1.0. The overall sensitivity of RPhCG/VhCG in the diagnosis of EP was 98%, the specificity was 100%, the positive predictive value was 100% and the negtive predictive value was 93%.
  
  
  CONCLUSIONS
  RPhCG/VhCG > 1.0 could be used to diagnose and differentiate EP from hIUP accurately.
authors.affiliation: Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China.
authors.forename: Yu-dong
authors.initials: YD
authors.lastname: Wang
authors.forename: Wen-xia
authors.initials: WX
authors.lastname: Zhao
authors.forename: Qi
authors.initials: Q
authors.lastname: Lu
authors.forename: Yin-cheng
authors.initials: YC
authors.lastname: Teng
authors.forename: Feng
authors.initials: F
authors.lastname: Sun
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Cheng
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D006063:Chorionic Gonadotropin / Q000097:blood*; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D006465:Hemoperitoneum / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood* / Q000175:diagnosis*; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin