title: 2',4'-BNA bearing a chiral guanidinopyrrolidine-containing nucleobase with potent ability to recognize the CG base pair in a parallel-motif DNA triplex.
abstract: In order to expand the target sequence used in triplex DNA formation, seven novel nucleotide analogues were synthesized and incorporated into triplex-forming oligonucleotides by post-elongation modification approaches. Among them, , equipped with a suitable restricted conformation of sugar and nucleobase moieties, was found to have the highest sequence-selectivity and affinity towards CG base pairs within double-stranded DNA.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan. hari@phs.osaka-u.ac.jp
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hari
authors.forename: Masaaki
authors.initials: M
authors.lastname: Akabane
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D019791:Guanidine / Q000031:analogs & derivatives*; D011759:Pyrrolidines / Q000737:chemistry*
chemical_list: D011759:Pyrrolidines; C051802:triplex DNA; D004247:DNA; D019791:Guanidine