title: [Recent progress of the aptamer-based antiviral drugs].
abstract: Aptamers are capable of binding a wide range of biomolecular targets with high affinity and specificity. It has been widely developed for diagnostic and therapeutic purposes. Because of unique three dimensional structures and cell-membrane penetration, aptamers inhibit virus infection not only through binding specific target, such as the viral envelope, genomic site, enzyme, or other viral components, but also can be connected to each other or with siRNA jointly achieve antiviral activity. Taking human immunodeficiency virus and hepatitis C virus as examples, this paper reviewed the effects and mechanisms of aptamers on disturbing viral infection and replication steps. It may provide an insight to the development of aptamer-based new antiviral drugs.
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhu
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Lü
authors.forename: Hui-Yong
authors.initials: HY
authors.lastname: Yang
authors.forename: Jun-Sheng
authors.initials: JS
authors.lastname: Lin
authors.forename: Qi-Zhao
authors.initials: QZ
authors.lastname: Wang
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology; D052157:Aptamers, Nucleotide / Q000494:pharmacology* / Q000627:therapeutic use; D016679:Genome, Viral / Q000187:drug effects; D006678:HIV / Q000187:drug effects*; D054303:HIV Reverse Transcriptase / Q000378:metabolism; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008268:Macular Degeneration / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D009838:Oligodeoxyribonucleotides / Q000627:therapeutic use; D034741:RNA, Small Interfering / Q000494:pharmacology; D052156:SELEX Aptamer Technique; D014759:Viral Envelope Proteins / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: C513936:AGRO 100; D000998:Antiviral Agents; D052157:Aptamers, Nucleotide; D009838:Oligodeoxyribonucleotides; D034741:RNA, Small Interfering; D014759:Viral Envelope Proteins; C495058:pegaptanib; D054303:HIV Reverse Transcriptase