title: Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives.
abstract: An efficient and powerful organocatalytic cascade reaction was achieved for the synthesis of biologically important chiral spiro[pyrrolidin-3,2'-oxindoles] using very simple and readily available starting materials. Three C-C bonds and four contiguous stereogenic centers including one quaternary stereocenter were established in a single operation with reasonable yields and good stereoselectivity.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Hu
authors.forename: Yun-Han
authors.initials: YH
authors.lastname: Li
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D061565:Cycloaddition Reaction; D007211:Indoles / Q000737:chemistry*; D000078183:Oxindoles; D011522:Protons; D013141:Spiro Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D000078183:Oxindoles; D011522:Protons; D013141:Spiro Compounds; C022960:2-oxindole