title: A construction of novel iron-foam-based calcium phosphate/chitosan coating biodegradable scaffold material.
abstract: Slow corrosion rate and poor bioactivity restrict iron-based implants in biomedical application. In this study, we design a new iron-foam-based calcium phosphate/chitosan coating biodegradable composites offering a priority mechanical and bioactive property for bone tissue engineering through electrophoretic deposition (EPD) followed by a conversion process into a phosphate buffer solution (PBS). Tensile test results showed that the mechanical property of iron foam could be regulated through altering the construction of polyurethane foam. The priority coatings were deposited from 40% nano hydroxyapatite (nHA)/ethanol suspension mixed with 60% nHA/chitosan-acetic acid aqueous solution. In vitro immersion test showed that oxidation-iron foam as the matrix decreased the amount of iron implanted and had not influence on the bioactivity of this implant, obviously. So, this method could also be a promising method for the preparation of a new calcium phosphate/chitosan coating on foam construction.
authors.affiliation: Department of Neuro Intern, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Wen
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Yibo
authors.initials: Y
authors.lastname: Liu
authors.forename: Changjun
authors.initials: C
authors.lastname: Wu
authors.forename: Changsong
authors.initials: C
authors.lastname: Dai
mesh_terms: D001673:Biodegradation, Environmental; D002021:Buffers; D002118:Calcium / Q000032:analysis; D002130:Calcium Phosphates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D017886:Durapatite / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry; D004595:Electroplating; D007501:Iron / Q000737:chemistry*; D008422:Materials Testing; D055595:Mechanical Phenomena; D046529:Microscopy, Electron, Transmission; D010084:Oxidation-Reduction; D010758:Phosphorus / Q000032:analysis; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D002021:Buffers; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D004573:Electrolytes; D010758:Phosphorus; D048271:Chitosan; D017886:Durapatite; C020243:calcium phosphate; D007501:Iron; D002118:Calcium
keywords: Bioactive property; Calcium phosphate coating; Electrophoretic deposition; Iron foam