title: Soluble receptor for urokinase plasminogen activator in community-acquired pneumonia in children.
abstract: Community-acquired pneumonia (CAP) is a leading single cause of mortality in children under 5 years of age. In search of new diagnostic markers, soluble urokinase plasminogen activator receptor (suPAR) seems to offer promise as a novel clinical tool. The goal of the present study was to assess the relation between suPAR and the severity of CAP. suPAR was measured in 74 (39 males, 35 females) patients aged from 1 month to about 15 years. Correlation between the level of suPAR and inflammatory markers (white blood cell, neutrophil count, C-reactive protein-CRP, and procalcitonin-PCT) was assessed by Spearmann's rank coefficient. We found that the median suPAR level in children with pneumonia was 8.29 ng/mL (range 2.44-18.31 ng/mL). In the multivariate logit model, age and CRP level were statistically important. The older children (age above the median value) had higher suPAR (above the median value) less frequently than the younger children (OR = 0.31), whereas the children with greater CRP values (above the median value) had higher suPAR levels than the children with lower CRP concentration (under the median value) (OR = 4.54). There was also a positive correlation between suPAR and PCT levels. In conclusion, we demonstrate a positive correlation between serum suPAR and the non-specific inflammatory markers CRP and PCT in the community acquired pneumonia in children.
authors.affiliation: Department of Pediatrics, Medical Center of Postgraduate Education, 99-103 Marymoncka St., 01-813, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Wrotek
authors.forename: K
authors.initials: K
authors.lastname: Pawlik
authors.forename: T
authors.initials: T
authors.lastname: Jackowska
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007249:Inflammation; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000166:cytology; D011014:Pneumonia / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism; D055293:Receptors, Urokinase Plasminogen Activator / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D055293:Receptors, Urokinase Plasminogen Activator; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide