title: Investigations on the role of π-π interactions and π-π networks in eNOS and nNOS proteins.
abstract: π-π Interactions play an important role in the stability of protein structures. In the present study, we have analyzed the influence of π-π interactions in eNOS and nNOS proteins. The contribution of these π-π interacting residues in sequential separation, secondary structure involvement, solvent accessibility and stabilization centers has been evaluated. π-π interactions stabilize the core regions within eNOS and nNOS proteins. π-π interacting residues are evolutionary conserved. There is a significant number of π-π interactions in spite of the lesser natural occurrences of π-residues in eNOS and nNOS proteins. In addition to π-π interactions, π residues also form π-π networks in both eNOS and nNOS proteins which might play an important role in the structural stability of these protein structures.
authors.affiliation: Bioinformatics Division, School of Biosciences and Technology, VIT University, Vellore 632 014, Tamil Nadu, India.
authors.forename: Sivasakthi
authors.initials: S
authors.lastname: Vaideeswaran
authors.forename: Sudha
authors.initials: S
authors.lastname: Ramaiah
mesh_terms: D008958:Models, Molecular; D052248:Nitric Oxide Synthase Type I / Q000737:chemistry* / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III
keywords: ASA; Accessible surface area; NCI; Networks; Non-canonical interactions; PDB; Protein Data Bank; SC; Stability; eNOS; endothelial Nitric Oxide Synthase; nNOS; neuronal Nitric Oxide Synthase; stabilization center; π–π Interactions