title: Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer.
abstract: Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
authors.forename: Tzu-Yu
authors.initials: TY
authors.lastname: Liu
authors.forename: Waleed M
authors.initials: WM
authors.lastname: Hussein
authors.forename: Zhongfan
authors.initials: Z
authors.lastname: Jia
authors.forename: Zyta M
authors.initials: ZM
authors.lastname: Ziora
authors.forename: Nigel A J
authors.initials: NA
authors.lastname: McMillan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Monteiro
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
authors.forename: Mariusz
authors.initials: M
authors.lastname: Skwarczynski
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000627:therapeutic use*; D000595:Amino Acid Sequence; D000818:Animals; D019496:Cancer Vaccines / Q000138:chemical synthesis / Q000276:immunology / Q000627:therapeutic use*; D002478:Cells, Cultured; D057930:Click Chemistry; D061565:Cycloaddition Reaction; D005260:Female; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009368:Neoplasm Transplantation; D050725:Papillomavirus E7 Proteins / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D030361:Papillomavirus Infections / Q000473:pathology / Q000628:therapy* / Q000821:virology; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D047368:Tumor Burden; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology
chemical_list: D000180:Acrylic Resins; D000276:Adjuvants, Immunologic; D019496:Cancer Vaccines; D050725:Papillomavirus E7 Proteins; D010446:Peptide Fragments; C006903:carbopol 940