title: [Lapeyronie's disease].
abstract: BACKGROUND
  Lapeyronie's disease is a common condition affecting 3.4 to 9% of the male population. Knowledge of pathophysiology, natural history, and treatment outcomes can guide the care of patients.
  
  
  METHODS
  A literature review was carried out between 1940 and 2012 in Pubmed using the keywords: Lapeyronie's disease, Peyronie's disease (PD), pathophysiology of PD, surgical treatment for PD, medical treatment for PD.
  
  
  RESULTS
  Seventy-five articles were selected, including original articles, reviews, and recommendations in English or French. Few studies available are of level 1 and most of them are of 2b and 3 level of evidence.
  
  
  CONCLUSIONS
  The pathophysiology of Lapeyronie's disease is controversial. Medical treatments are ineffective. Surgery should be proposed when the curvature is stabilized, and the treatment of the concavity or convexity depends on the size of the erect penis, its curvature angle and erectile function. Penile implant must be proposed to patients when erectile dysfunction is combined with severe curvature.
authors.affiliation: CHU de Bordeaux, Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Ferretti
authors.forename: A
authors.initials: A
authors.lastname: Faix
authors.forename: S
authors.initials: S
authors.lastname: Droupy
mesh_terms: D006801:Humans; D008297:Male; D010411:Penile Induration / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy
keywords: Chirurgie du pénis; Courbure du pénis; Dysfonction érectile; Erectile dysfunction; Implants péniens; Lapeyronie's disease; Maladie de Lapeyronie; Medical penile surgery; Nesbit; Penile curvature; Penile implant; Penile plicature; TGF-β; Yachia