title: Genetic background affects susceptibility to tumoral stem cell reprogramming.
abstract: The latest studies of the interactions between oncogenes and its target cell have shown that certain oncogenes may act as passengers to reprogram tissue-specific stem/progenitor cell into a malignant cancer stem cell state. In this study, we show that the genetic background influences this tumoral stem cell reprogramming capacity of the oncogenes using as a model the Sca1-BCRABLp210 mice, where the type of tumor they develop, chronic myeloid leukemia (CML), is a function of tumoral stem cell reprogramming. Sca1-BCRABLp210 mice containing FVB genetic components were significantly more resistant to CML. However, pure Sca1-BCRABLp210 FVB mice developed thymomas that were not seen in the Sca1-BCRABLp210 mice into the B6 background. Collectively, our results demonstrate for the first time that tumoral stem cell reprogramming fate is subject to polymorphic genetic control.
authors.affiliation: Experimental Therapeutics and Translational Oncology Program; Instituto de Biología Molecular y Celular del Cáncer (IBMCC); CSIC/ Universidad de Salamanca; Salamanca, Spain; Institute of Biomedical Research of Salamanca (IBSAL); Salamanca, Spain.
authors.forename: Idoia
authors.initials: I
authors.lastname: García-Ramírez
authors.forename: Lucía
authors.initials: L
authors.lastname: Ruiz-Roca
authors.forename: Alberto
authors.initials: A
authors.lastname: Martín-Lorenzo
authors.forename: Oscar
authors.initials: O
authors.lastname: Blanco
authors.forename: María Begoña
authors.initials: MB
authors.lastname: García-Cenador
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: García-Criado
authors.forename: Carolina
authors.initials: C
authors.lastname: Vicente-Dueñas
authors.forename: Isidro
authors.initials: I
authors.lastname: Sánchez-García
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D014411:Neoplastic Stem Cells / Q000502:physiology*; D013953:Thymus Neoplasms / Q000235:genetics / Q000473:pathology*; D047368:Tumor Burden
chemical_list: D016044:Fusion Proteins, bcr-abl
keywords: cancer; cancer stem cell; cancer therapy; mouse model; oncogenes; stem cells; tumoral reprogramming