title: The triterpenoid fraction from Trichosanthes dioica root suppresses experimentally induced inflammatory ascites in rats.
abstract: BACKGROUND
  Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English, is a dioecious climber found wild throughout the plains of the Indian subcontinent and traditionally used in India for several medicinal purposes.
  
  
  OBJECTIVE
  The present study evaluated the protective effect of the triterpenoid enriched fraction from T. dioica root (CETD) against experimentally induced acute inflammatory ascites in Wistar albino rats.
  
  
  METHODS
  The CETD was administered orally at the different doses (25, 50 and 100 mg/kg body weight) to overnight fasted rats, and then ascites was induced by intraperitoneal administration of formalin solution. After 7 h, the rats were sacrificed and the volume of ascitic fluid was measured.
  
  
  RESULTS
  The CETD demonstrated significant (p < 0.01) reduction of ascitic fluid formation in a dose-dependent manner as compared with control.
  
  
  CONCLUSIONS
  The CETD produced significant and dose-dependent inhibition of experimentally induced inflammatory ascites in Wistar albino rats.
authors.affiliation: Division of Pharmacognosy, Bengal School of Technology, A College of Pharmacy , Sugandha, Hooghly 712102, West Bengal , India and.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Pallab Kanti
authors.initials: PK
authors.lastname: Haldar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D001201:Ascites / Q000139:chemically induced / Q000517:prevention & control*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005557:Formaldehyde; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D029778:Trichosanthes / Q000737:chemistry; D014315:Triterpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts; D014315:Triterpenes; D005557:Formaldehyde