title: [Pure red cell aplasia with thymoma/T-cell large granular lymphocyte leukemia: two cases report and literatures review].
abstract: OBJECTIVE
  To investigate the clinical and laboratory features of 2 cases of pure red cell aplasia (PRCA) with thymoma/T-cell large granular lymphocyte leukemia (T-LGLL), and to improve the recognition of the disease and the role of lymphocyte in its mechanism.
  
  
  METHODS
  Two cases of PRCA with thymoma/T-LGLL were reported and the related literatures were reviewed.
  
  
  RESULTS
  Case 1 was a 63-years old male with hemoglobin level of 54 g/L at admission. Case 2 was a 52-years old female with hemoglobin level of 79 g/L at admission. They were both diagnosed as PRCA with thymoma before admission to our hospital and had no benefit from their thymectomy. Further examinations in our hospital showed that CD3⁺CD4⁻CD8⁺CD57⁺ large granular lymphocytes amplified with clonal TCR rearrangement in their peripheral blood. The diagnosis of PRCA with thymoma/T-LGLL was clarified. Case 1 did not respond to any of the frontline therapies while case 2 responded completely to cyclosporine.
  
  
  CONCLUSIONS
  Both thymoma and T-LGLL could be the cause of secondary PRCA, lymphocyte proliferation may play critical role in the pathogenesis.
authors.affiliation: Therapeutic Center of Anemia, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Kang
authors.initials: K
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.forename: Guang-xin
authors.initials: GX
authors.lastname: Peng
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Jing
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Hui-hui
authors.initials: HH
authors.lastname: Fan
authors.forename: Lin
authors.initials: L
authors.lastname: Song
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Jing
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Feng-kui
authors.initials: FK
authors.lastname: Zhang
mesh_terms: D005260:Female; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000150:complications*; D013945:Thymoma / Q000150:complications*