title: Desmopressin administration in children with central diabetes insipidus: a retrospective review.
abstract: BACKGROUND
  Central diabetes insipidus (DI) is a rare disorder in children caused by a deficiency of antidiuretic hormone arginine (vasopressin). Desmopressin is the first line agent in management of central DI. However, one of the side effects of desmopressin is water intoxication and hyponatraemia. This study reviews the patterns of desmopressin use and side effects in our institution.
  
  
  METHODS
  Retrospective chart review of all patients with central DI followed up in one tertiary centre between 1 January 2008 and 31 December 2010.
  
  
  RESULTS
  Forty-one patients (22 males and 19 females) were included. Twelve patients (29.3%) had congenital and 29 patients (70.7%) had acquired DI, mostly as a result of intracranial tumours. Thirty-six (87.8%) patients were on oral desmopressin and the remaining on nasal formulation. The median oral dose was 9.5 (4.2-17.0) μg/kg/day with median frequency of 2.5 (2-3). The median nasal dose was 0.7 (0.4-1.4) μg/kg/day with median frequency of 2.0 (2-3.5). Fourteen patients (34.1%) were switched from nasal to oral desmopressin with the median dose conversion factor of 20.1 (10.7-31.8). Forty percent of patients on nasal desmopressin experienced hypo/hypernatraemia compared to 18.1% on oral, however, there were no significance difference between standardized hypo/hypernatraemia episodes per treatment year.
  
  
  CONCLUSIONS
  Oral desmopressin is used in the majority of our patients including infants and toddlers. There is wide inter-individual variation in dose requirement and dosing intervals. Management of central diabetes insipidus remains a challenge in adipsic patients and in young children during intercurrent illness regardless of the desmopressin formulation.
authors.forename: Hooi Leng
authors.initials: HL
authors.lastname: Ooi
authors.forename: Ann M
authors.initials: AM
authors.lastname: Maguire
authors.forename: Geoffrey R
authors.initials: GR
authors.lastname: Ambler
mesh_terms: D000293:Adolescent; D050034:Antidiuretic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage* / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin