title: Metabolomic profile of term infants of gestational diabetic mothers.
abstract: OBJECTIVE
  Maternal diabetes increases the risk of perinatal mortality and morbidity, but the maintenance of antenatal normal glucose serum prevents the majority of neonatal complications. The aim of our study is to compare the metabolomic profile of infants of gestational diabetic mothers (IGDMs) to that of infants of healthy mothers to evaluate if differences remain despite a strict control of gestational diabetes.
  
  
  METHODS
  We performed the metabolomics study in cord serum sampled from 30 term IGDMs and 40 controls recording the occurrence of the most frequent complications in IGDMs.
  
  
  RESULTS
  We demonstrated that IGDMs have lower level of glucose and higher level of pyruvate, histidine, alanine, valine, methionine, arginine, lysine, hypoxanthine, lipoprotein and lipid than controls, but we did not find any clinical differences.
  
  
  CONCLUSIONS
  Our results suggest that prolonged fetal exposure to hyperglycemia during pregnancy can change neonatal metabolomic profile at birth without affecting the clinical course.
authors.affiliation: Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence , Florence , Italy .
authors.forename: Carlo
authors.initials: C
authors.lastname: Dani
authors.forename: Cecilia
authors.initials: C
authors.lastname: Bresci
authors.forename: Elettra
authors.initials: E
authors.lastname: Berti
authors.forename: Serena
authors.initials: S
authors.lastname: Ottanelli
authors.forename: Giorgio
authors.initials: G
authors.lastname: Mello
authors.forename: Federico
authors.initials: F
authors.lastname: Mecacci
authors.forename: Rita
authors.initials: R
authors.lastname: Breschi
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Hu
authors.forename: Leonardo
authors.initials: L
authors.lastname: Tenori
authors.forename: Claudio
authors.initials: C
authors.lastname: Luchinat
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D008297:Male; D055442:Metabolome; D055432:Metabolomics; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism; D047929:Term Birth / Q000378:metabolism