title: Synthesis of tricyclic condensed rings incorporating the pyrazole or isoxazole moieties bonded to a 4-piperidinyl substituent.
abstract: In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.
authors.affiliation: Dipartimento di Chimica e Farmacia, Università di Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy. pinlab@uniss.it
authors.forename: Giansalvo
authors.initials: G
authors.lastname: Pinna
authors.forename: Giovanni
authors.initials: G
authors.lastname: Loriga
authors.forename: Gérard A
authors.initials: GA
authors.lastname: Pinna
authors.forename: Giorgio
authors.initials: G
authors.lastname: Chelucci
mesh_terms: D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry; D019811:Hydroxylamine / Q000737:chemistry; D007555:Isoxazoles / Q000737:chemistry*; D015394:Molecular Structure; D010881:Piperidones / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D014150:Antipsychotic Agents; D006834:Hydrazines; D007555:Isoxazoles; D010881:Piperidones; D011720:Pyrazoles; D019811:Hydroxylamine; C031280:pyrazole