title: Fasting glucagon-like peptide-1 in patients with overt hyperthyroidism and euthyroid congenital hypothyroidism.
abstract: OBJECTIVE
  To investigate the influence of overt hyperthyroidism and euthyroid congenital hypothyroidism on fasting glucagon-like peptide-1 (GLP-1) levels.
  
  
  METHODS
  A total of 30 untreated overt hyperthyroidism patients, 17 euthyroid congenital hypothyroidism children, and age- and sex-matched controls were enrolled. Levels of GLP-1, insulin, glucose, and homeostasis model assessment (HOMA-IR) were measured and evaluated.
  
  
  RESULTS
  Fasting GLP-1, blood glucose, insulin, and HOMR-IR levels were higher in patients with overt hyperthyroidism than in controls (p=0.030, p=0.008, p=0.004, p=0.037, respectively). These parameters in euthyroid hypothyroidism were similar to the controls. In euthyroid congenital hypothyroidism and overt hyperthyroidism patients, serum GLP-1 levels were not correlated with thyroid hormone, blood glucose, insulin, and HOMR-IR.
  
  
  CONCLUSIONS
  Fasting GLP-1 levels in the peripheral circulation were significantly increased in overt hyperthyroidism, however, they were no different in euthyroid congenital hypothyroidism.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Cheng
authors.forename: Hong-Ni
authors.initials: HN
authors.lastname: Yue
authors.forename: Shao-Gang
authors.initials: SG
authors.lastname: Ma
authors.forename: Yue
authors.initials: Y
authors.lastname: Jin
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Feng
authors.initials: F
authors.lastname: Bai
mesh_terms: D000293:Adolescent; D000328:Adult; D003409:Congenital Hypothyroidism / Q000097:blood*; D005215:Fasting; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D008297:Male; D055815:Young Adult
chemical_list: D052216:Glucagon-Like Peptide 1