title: Whole brain CT perfusion deficits using 320-detector-row CT scanner in TIA patients are associated with ABCD2 score.
abstract: BACKGROUND
  Transient ischemic attacks (TIA) are cerebral ischemic events without infarction. The uses of CT perfusion (CTP) techniques such as cerebral blood volume (CBV), time to peak (TTP), mean transit time (MTT) and cerebral blood flow (CBF) provide real time data about ischemia. It has been shown that CTP changes occur in less sensitive CTP scanners in patients with TIA. Larger detector row CTP (whole brain perfusion studies) may show that CTP abnormalities are more prevalent than previously noted. It is also unclear if these changes are associated with TIA severity.
  
  
  OBJECTIVE
  To demonstrate that TIA patients are associated with perfusion deficits using whole brain 320-detector-row CT perfusion, and to determine an association between ABCD2 score and perfusion deficit using whole brain perfusion.
  
  
  METHODS
  We retrospectively reviewed all TIA patients for CTP deficits from 2008-2010. Perfusion imaging was reviewed at admission; and it was determined if a perfusion deficit was present along with vascular territory involved.
  
  
  RESULTS
  Of 364 TIA patients, 62 patients had CTP deficits. The largest group of patients had MCA territory involved with 48 of 62 patients (77.42%). The most common perfusion abnormality was increased TTP with 46 patients (74.19%). The ABCD2 score was reviewed in association with perfusion deficit. Increased age >60, severe hypertension (>180/100 mmHg), patients with speech abnormalities, and duration of symptoms >10 min were associated with a perfusion deficit but history of diabetes or minimal/moderate hypertension (140/90-179/99 mmHg) was not. There was no association between motor deficit and perfusion abnormality.
  
  
  CONCLUSIONS
  Perfusion deficits are found in TIA patients using whole brain CTP and associated with components of the ABCD2 score.
authors.affiliation: 1Department of Neurology, Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: Bijal K
authors.initials: BK
authors.lastname: Mehta
authors.forename: Ghulam
authors.initials: G
authors.lastname: Mustafa
authors.forename: Aaron
authors.initials: A
authors.lastname: McMurtray
authors.forename: Mohammed W
authors.initials: MW
authors.lastname: Masud
authors.forename: Sameer K
authors.initials: SK
authors.lastname: Gunukula
authors.forename: Haris
authors.initials: H
authors.lastname: Kamal
authors.forename: Amit
authors.initials: A
authors.lastname: Kandel
authors.forename: Abdelrahman
authors.initials: A
authors.lastname: Beltagy
authors.forename: Ping
authors.initials: P
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed