title: Acute mono-megakaryoblastic leukemia associated with extreme thrombocytosis and complex karyotype abnormalities.
abstract: Patient: Female, 55Final Diagnosis: Acute leukemiaSymptoms: ThrombocytosisMedication: Idarubicin HCl (Zavedos), PfizerClinical Procedure: -Specialty: Hematology.
  
  
  OBJECTIVE
  Adverse effect of drug therapy.
  
  
  BACKGROUND
  Thrombocytosis is usually seen in myeloproliferative disorders (MPD) and seldom in acute myeloid leukemias (AML). In acute megakaryoblastic leukemia, platelet counts might exceed 1000×109/L in approximately 30% of patients, while others are frequently presented by cytopenias. To our best knowledge there is no report in the literature on acute mono-megakaryoblastic leukemia, especially with extreme thrombocytosis and complex karyotype abnormalities.
  
  
  METHODS
  We present the case of a 55-year-old woman with acute mono-megakaryoblastic leukemia with extreme thrombocytosis (greater than 2000×109/L) and complex karyotype abnormalities. The patient was first treated with anti-aggregate therapy and later the patient was put on a regimen consisting of idarubicin 10 mg/m2daily for 3 days and 200 mg Cytosar daily for 7 days. However, a severe pancytopenia occurred at the first day after chemotherapy and the patient died from intracranial hemorrhage.
  
  
  CONCLUSIONS
  Extreme thrombocytosis and complex karyotype abnormalities in acute mono-megakaryoblastic leukemia are associated with poor outcome.
authors.affiliation: Department of Hematology, Shengjing Hospital, China Medical University, Liaoning, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Yanping
authors.initials: Y
authors.lastname: Hu
authors.forename: Jihong
authors.initials: J
authors.lastname: Zhang
authors.forename: Miao
authors.initials: M
authors.lastname: Miao
authors.forename: Ke
authors.initials: K
authors.lastname: Zhu
authors.forename: Aijun
authors.initials: A
authors.lastname: Liao
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Zhuogang
authors.initials: Z
authors.lastname: Liu
keywords: acute leukemia; karyotype abnormalities; thrombocytosis