title: Metabolic disturbance in PCOS: clinical and molecular effects on skeletal muscle tissue.
abstract: Polycystic ovary syndrome is a complex hormonal disorder affecting the reproductive and metabolic systems with signs and symptoms related to anovulation, infertility, menstrual irregularity and hirsutism. Skeletal muscle plays a vital role in the peripheral glucose uptake. Since PCOS is associated with defects in the activation and pancreatic dysfunction of β-cell insulin, it is important to understand the molecular mechanisms of insulin resistance in PCOS. Studies of muscle tissue in patients with PCOS reveal defects in insulin signaling. Muscle biopsies performed during euglycemic hyperinsulinemic clamp showed a significant reduction in glucose uptake, and insulin-mediated IRS-2 increased significantly in skeletal muscle. It is recognized that the etiology of insulin resistance in PCOS is likely to be as complicated as in type 2 diabetes and it has an important role in metabolic and reproductive phenotypes of this syndrome. Thus, further evidence regarding the effect of nonpharmacological approaches (e.g., physical exercise) in skeletal muscle of women with PCOS is required for a better therapeutic approach in the management of various metabolic and reproductive problems caused by this syndrome.
authors.affiliation: School of Physical Education and Sport, Laboratory of Applied Nutrition and Metabolism, University of São Paulo, 05508-030 São Paulo, SP, Brazil. wagnerdantas@usp.br
authors.forename: Wagner Silva
authors.initials: WS
authors.lastname: Dantas
authors.forename: Bruno
authors.initials: B
authors.lastname: Gualano
authors.forename: Michele Patrocínio
authors.initials: MP
authors.lastname: Rocha
authors.forename: Cristiano Roberto Grimaldi
authors.initials: CR
authors.lastname: Barcellos
authors.forename: Viviane
authors.initials: V
authors.lastname: dos Reis Vieira Yance
authors.forename: José Antonio Miguel
authors.initials: JA
authors.lastname: Marcondes
mesh_terms: D005260:Female; D006801:Humans; D008659:Metabolic Diseases / Q000175:diagnosis* / Q000378:metabolism*; D008954:Models, Biological; D009124:Muscle Proteins / Q000378:metabolism*; D009135:Muscular Diseases / Q000175:diagnosis* / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D009124:Muscle Proteins