title: Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety.
abstract: 3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.
authors.affiliation: Department of Chemistry, Canara Engineering College, Benjanapadavu Mangalore, Karnataka, India. priyafrank@gmail.com
authors.forename: Priya V
authors.initials: PV
authors.lastname: Frank
authors.forename: Mahesha
authors.initials: M
authors.lastname: Manjunatha Poojary
authors.forename: Naral
authors.initials: N
authors.lastname: Damodara
authors.forename: Chandrashekhar
authors.initials: C
authors.lastname: Chikkanna
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D004791:Enzyme Inhibitors / Q000819:agonists / Q000737:chemistry; D007093:Imidazoles / Q000819:agonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008352:Mannich Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D007093:Imidazoles; D008352:Mannich Bases; D010069:Oxadiazoles; C029899:imidazole