title: Lymphogranuloma venereum diagnoses among men who have sex with men in the U.K.: interpreting a cross-sectional study using an epidemic phase-specific framework.
abstract: OBJECTIVE
  To investigate the drivers behind the epidemic expansion of lymphogranuloma venereum (LGV) cases in late 2009 to help inform infection control.
  
  
  METHODS
  An epidemic curve of all LGV diagnoses between 2003 and mid-2012 was plotted and divided into the initial detection period, and endemic, growth and hyperendemic phases. Detailed clinical and behavioural data were collected and logistic regression was used to compare the characteristics of diagnoses made during the growth and endemic phases.
  
  
  RESULTS
  Between April 2003 and June 2012, 2138 cases of LGV were diagnosed. Enhanced surveillance data were available for 1370 of whom 1353 were men who have sex with men (MSM). 98% of MSM presented with proctitis, 82% were HIV positive, 20% were hepatitis C virus (HCV) antibody positive, and 67% lived in London. Growth phase cases (n=488) were more likely to report meeting sexual contacts at sex parties (11% vs. 6%, p=0.014), unprotected receptive or insertive oral intercourse (93% vs. 86%, p=0.001; 92% vs. 85%, p=0.001) and sharing sex toys (8% vs 4%; p=0.011), and to be diagnosed HIV positive (86% vs. 80%; p=0.014), than endemic phase cases (n=423). Unprotected receptive anal intercourse was equally likely to be reported in both phases (71% vs. 73%). After adjustment, cases in the growth phase were more likely to meet new contacts at sex parties (p=0.031) and be HIV positive (p=0.045).
  
  
  CONCLUSIONS
  Rapid epidemic growth coincided with an intensification of unprotected sexual activity among a core population of HIV-positive MSM. Efforts to develop innovative interventions for this hard-to-reach population are needed.
authors.affiliation: HIV & STI Department, Public Health England (PHE), Colindale, , London, UK.
authors.forename: Gwenda
authors.initials: G
authors.lastname: Hughes
authors.forename: Sarah
authors.initials: S
authors.lastname: Alexander
authors.forename: Ian
authors.initials: I
authors.lastname: Simms
authors.forename: Stefano
authors.initials: S
authors.lastname: Conti
authors.forename: Helen
authors.initials: H
authors.lastname: Ward
authors.forename: Cassandra
authors.initials: C
authors.lastname: Powers
authors.forename: Catherine
authors.initials: C
authors.lastname: Ison
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D019353:Endemic Diseases; D018451:Homosexuality, Male; D006801:Humans; D008219:Lymphogranuloma Venereum / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012309:Risk-Taking; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
keywords: Epidemiology (General); Gay Men; Lymphogranuloma Venereum; Sexual Behaviour