title: [Rapid identification of 14 bile acids contained in Qingkailing injection by HPLC-ESI-MS/MS].
abstract: OBJECTIVE
  To investigate ESI-MS/MS fragmentation pattern of bile acids contained in Qingkailing injection, and the rapid identification method.
  
  
  METHODS
  HPLC-ESI-MS/MS technology was adopted to investigate ESI-MS/MS fragmentation pattern of five bile acids contained in Qingkailing injection, and rapidly identify bile acids contained in Qingkailing injection from eight different manufacturers.
  
  
  RESULTS
  5 bile acids showed similar ESI-MS/MS fragmentation patterns, based on which 14 bile acids were rapidly separated from Qingkailing injection. Among them, 11 were found in injections of all of the manufacturers, and the rest three were found in individual manufacturers.
  
  
  CONCLUSIONS
  HPLC-ESI-MS/MS is used to rapidly identify bile acids from complex material systems, which provides an effective method for interpreting the complex material base of compound traditional Chinese medicine preparations and enhance the quality standards.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. zhangjiayu0615@163.com
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Zhang
authors.forename: Lu-Yan
authors.initials: LY
authors.lastname: Dong
authors.forename: Jian-Qiu
authors.initials: JQ
authors.lastname: Lu
authors.forename: Yan-Jiang
authors.initials: YJ
authors.lastname: Qiao
mesh_terms: D001647:Bile Acids and Salts / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D001647:Bile Acids and Salts; D004365:Drugs, Chinese Herbal; C504928:Qingkailing