title: [Preventive effects of jinghua weikang capsule on NSAID-induced injury to the mucosa of the small intestine: an experimental research].
abstract: OBJECTIVE
  To study the preventive effects of jinghua weikang capsule (JWC) on nonsteroidal anti-inflammatory drugs (NSAIDs) induced injury to the mucosa of the small intestine.
  
  
  METHODS
  Thirty-two Wistar rats were randomly divided into four groups, i.e., the blank control group, the model group, the JWC group, and the esomeprazole group. Diclofenac was administered to rats in the model group, the JWC group, and the esomeprazole group at the daily dose of 15 mg/kg. JWC and esomeprazole was respectively given to those in the JWC group, and the esomeprazole group one day ahead. Normal saline was given to rats in the blank control group. Rats were killed 3 days later. The pathological changes of the small intestine were observed by hematoxylin and eosin stain.
  
  
  RESULTS
  Compared with the blank control group, the general score for the small intestine (4.63 +/-0.52 vs 0.00 +/-0. 00) and the pathological score (4.00 +/-0.90 vs 0.00 +/-0. 00) obviously increased in the model group, showing statistical difference (P <0.05). Compared with the model group, the general score for the small intestine (1.88 +/-0.99) and the pathological score (2.11 +/-1.11) obviously decreased in the JWG group, showing statistical difference (P <0.05). Compared with the model group, the general score for the small intestine (2.75 +/-1.28) and the pathological score (2. 30 +/-0.94) obviously decreased in the esomeprazole group, showing statistical difference (P <0.05).
  
  
  CONCLUSIONS
  JWC could prevent NSAIDs induced injury to the mucosa of the small intestine.
authors.affiliation: Department of Digestive Eiseases, First Affiliated Hospital, Baotou Medical College, Neimenggu 014010, China.
authors.forename: Rui-Feng
authors.initials: RF
authors.lastname: Ding
authors.forename: Yuan-Hu
authors.initials: YH
authors.lastname: Guo
authors.forename: Wen-Peng
authors.initials: WP
authors.lastname: Han
authors.forename: Ai-Yu
authors.initials: AY
authors.lastname: Wang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Xie
authors.forename: Peng-cheng
authors.initials: PC
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D064098:Esomeprazole / Q000494:pharmacology / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C527855:jinghua weikang; D004008:Diclofenac; D064098:Esomeprazole