title: CSF3R is mutated in chronic neutrophilic leukemia and atypical CML.
abstract: Colony-stimulating factor 3 receptor (CSF3R) is mutated in 59% of CNL or atypical CML cases.
mesh_terms: D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D053612:Janus Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D058990:Molecular Targeted Therapy; D009154:Mutation; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D016184:Receptors, Colony-Stimulating Factor / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C517047:CSF3R protein, human; D016184:Receptors, Colony-Stimulating Factor; D011505:Protein-Tyrosine Kinases; D053612:Janus Kinases; C403262:TNK2 protein, human