title: No impact of obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children.
abstract: OBJECTIVE
  An obesity risk allele at the NEGR1 locus was shown to be associated with weight regain after a lifestyle intervention in obese adults. Independent confirmation and studies in children are lacking. Therefore, we analyzed the impact of this and 11 additional obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children.
  
  
  METHODS
  We longitudinally analyzed the changes in weight status as body mass index standard deviation score (BMI-SDS) in 282 overweight children (10.6 ± 2.5 years, 47% male, BMI 27.1 ± 3.9 kg/m2) both at the end of a 1-year lifestyle intervention and at 1 year after the end of intervention. We genotyped obesity risk single nucleotide polymorphisms (SNPs) derived from genome-wide association studies in or in proximity to the following genes: NEGR1, TNKS, SDCCAG8, FTO, MC4R, TMEM18, PTER, MTCH2, SH2B1, MAF, NPC1, and KCTD15.
  
  
  RESULTS
  The children reduced their BMI-SDS (-0.28 ± 0.35; p<0.001) during intervention and increased their BMI-SDS between the end of intervention and 1 year later (+0.05 ± 0.36; p=0.027). None of the SNPs including NEGR1 was related significantly to weight regain.
  
  
  CONCLUSIONS
  We found no evidence for effects of any of the GWAS-based obesity marker alleles on weight regain in the course of 1 year after an intervention.
authors.forename: Anke
authors.initials: A
authors.lastname: Hinney
authors.forename: Barbara
authors.initials: B
authors.lastname: Wolters
authors.forename: Carolin
authors.initials: C
authors.lastname: Pütter
authors.forename: Harald
authors.initials: H
authors.lastname: Grallert
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: Johannes
authors.initials: J
authors.lastname: Hebebrand
authors.forename: Thomas
authors.initials: T
authors.lastname: Reinehr
mesh_terms: D015992:Body Mass Index; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D015430:Weight Gain / Q000235:genetics*