title: [Study of the effect of thiosemicarbazones against Toxoplasma gondii].
abstract: Toxoplasmosis is a neglected disease, with an estimated occurrence of one-third of the population worldwide. Research in medicinal chemistry has for some years been pursuing the development of new drugs against toxoplasmosis, because current treatments cause serious side effects in the patient. The use of thiosemicarbazones as an alternative option for the treatment of various diseases has been published in recent years, due to their, among others, anticancer, antimalarial, antitrypanosomal, antibacterial, and antitoxoplasmosis activities, the latter being the subject of this study, which is based upon biological analyses and tests of the response of Toxoplasma gondii in the presence of thiosemicarbazones.
authors.affiliation: Laboratorio de Ciências Química, Universidade Estadual do Norte Fluminense, Avenue Alberto Lamego, 2000 Horto, CEP 28015620, Campos dos Goytacazes, RJ, Brésil. mabgomes@uenf.br
authors.forename: Marco Antônio G B
authors.initials: MA
authors.lastname: Gomes
authors.forename: Gabriela M
authors.initials: GM
authors.lastname: Carreira
authors.forename: Daniela P V
authors.initials: DP
authors.lastname: Souza
authors.forename: Paulo Marcos R
authors.initials: PM
authors.lastname: Nogueira
authors.forename: Edésio J T
authors.initials: EJ
authors.lastname: de Melo
authors.forename: Edmilson J
authors.initials: EJ
authors.lastname: Maria
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000494:pharmacology*; D014122:Toxoplasma / Q000187:drug effects*; D014123:Toxoplasmosis / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D013882:Thiosemicarbazones
keywords: Anti-Toxoplasma gondii; Anti-parasitic; Antiparasitaires; Thiosemicarbazones; Toxoplasmose