title: Immunocompetent nontransgenic mouse models for studying hepatitis B virus immune responses.
abstract: Although the chronicity of hepatitis B virus (HBV) infection is the result of impaired HBV-specific immune responses that cannot eliminate or clear the infected hepatocytes efficiently, many issues remained unsettled. It is thus crucial to have a suitable laboratory animal to study the immunopathogenesis of HBV infection and the mechanisms of HBV persistence. To meet the requirement of a mouse model resembling natural chronic HBV infection in human, there are several approaches in the development of mouse animal model by using hydrodynamic-based transfection of HBV DNA, delivery of adenovirus or adeno-associated viral vectors containing HBV DNA for studying HBV immune responses. These immunocompetent nontransgenic mouse animal models will provide new approaches to investigate the mechanisms of immune pathogenesis in HBV infection.
authors.affiliation: Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Horng-Tay
authors.initials: HT
authors.lastname: Tzeng
authors.forename: Ping-Ning
authors.initials: PN
authors.lastname: Hsu
authors.forename: Pei-Jer
authors.initials: PJ
authors.lastname: Chen
mesh_terms: D000256:Adenoviridae; D000818:Animals; D004279:DNA, Viral; D000229:Dependovirus; D004195:Disease Models, Animal; D005822:Genetic Vectors; D016679:Genome, Viral / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000235:genetics / Q000276:immunology*; D022781:Hepatocytes / Q000276:immunology / Q000821:virology; D006801:Humans; D007121:Immunocompetence / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D014162:Transfection / Q000379:methods
chemical_list: D004279:DNA, Viral
keywords: hepatitis B virus; immune response; mouse animal model