title: Preventive effects of polysaccharides from Liriope spicata var. prolifera on diabetic nephropathy in rats.
abstract: This study was undertaken to investigate preventive effects of polysaccharides (LSP) from Liriope spicata var. prolifera on diabetic nephropathy in rats, which were induced by high fat-fed and low-dose streptozotocin (STZ). The levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in diabetic rats were significantly decreased after treated with LSP for 28 days. Additional, the glucose tolerance of diabetes rats showed improvement after administration of LSP. The results also indicated that LSP were able to normalize hyperlipidemia, ameliorate oxidative stress, improve renal function parameters, inhibit the structural damages of kidney tissue and down-regulate the system of advanced glycation end products - receptor for advanced glycation end products (AGE-RAGE). In conclusion, LSP had potential preventive effects on diabetic nephropathy in diabetic rats.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, China.
authors.forename: Zuo-qi
authors.initials: ZQ
authors.lastname: Xiao
authors.forename: Yong-long
authors.initials: YL
authors.lastname: Wang
authors.forename: Yao-dong
authors.initials: YD
authors.lastname: Yue
authors.forename: Yu-tang
authors.initials: YT
authors.lastname: Zhang
authors.forename: Cui-ping
authors.initials: CP
authors.lastname: Chen
authors.forename: Luo-sheng
authors.initials: LS
authors.lastname: Wan
authors.forename: Bin
authors.initials: B
authors.lastname: Deng
authors.forename: Zhao-xia
authors.initials: ZX
authors.lastname: Liu
authors.forename: Jia-chun
authors.initials: JC
authors.lastname: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose; D002241:Carbohydrates / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D005215:Fasting / Q000097:blood; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D031424:Liriope Plant / Q000737:chemistry*; D008297:Male; D008970:Molecular Weight; D009005:Monosaccharides / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D002241:Carbohydrates; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D007328:Insulin; D008055:Lipids; D009005:Monosaccharides; D010936:Plant Extracts; D011134:Polysaccharides; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic
keywords: Diabetic nephropathy; Hyperglycemic; Liriope spicata var. prolifera; Polysaccharide