title: Technical eligibility for treatment of magnetic resonance-guided focused ultrasound surgery.
abstract: OBJECTIVE
  This study was designed to evaluate the technical eligibility for magnetic resonance-guided focused ultrasound surgery (MRgFUS) treatment of women with symptomatic fibroids.
  
  
  METHODS
  Technical eligibility for MRgFUS treatment without mitigation techniques was evaluated retrospectively in 783 premenopausal women (median age, 44.2 years) with symptomatic fibroids who applied for uterine artery embolization (UAE) at our institution from 2001 to 2012. Technical eligibility for MRgFUS was defined as primary study endpoint. Technical ineligibility was assessed on the basis of MRI criteria, such as bowel interposition/foreign material in the ultrasound beam path, more than five fibroids, distance from fibroid to sacral bone surface, fibroid size/shape, severe concomitant adenomyosis or extensive cutaneous scars in accordance to the US Food and Drug Administration approvals. Secondary study endpoint was defined as evaluation of the most frequent exclusion criteria and differences in technical eligibility for MRgFUS and UAE.
  
  
  RESULTS
  On the basis of MRI, 38.9% of women who applied for UAE were found to be technically eligible for MRgFUS treatment without mitigation techniques. Most frequent reason for ineligibility was bowel interposition in the ultrasound beam path (60.4%). Differences in technical eligibility for MRgFUS (38.9%) and UAE (99.2%) were significant (P < 0.001).
  
  
  CONCLUSIONS
  MRgFUS treatment is technically possible in up to 40% of women with symptomatic fibroids. The most frequent exclusion criterion is the presence of bowel in the ultrasound beam path.
authors.affiliation: Department of Radiology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany, vera.froeling@charite.de.
authors.forename: V
authors.initials: V
authors.lastname: Fröling
authors.forename: T J
authors.initials: TJ
authors.lastname: Kröncke
authors.forename: N F
authors.initials: NF
authors.lastname: Schreiter
authors.forename: C
authors.initials: C
authors.lastname: Scheurig-Muenkler
authors.forename: F
authors.initials: F
authors.lastname: Collettini
authors.forename: B
authors.initials: B
authors.lastname: Hamm
authors.forename: A
authors.initials: A
authors.lastname: Beck
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis* / Q000601:surgery*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018579:Patient Selection; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D012189:Retrospective Studies; D018570:Risk Assessment; D016896:Treatment Outcome; D059708:Ultrasonic Surgical Procedures / Q000379:methods*; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000601:surgery*