title: Association study of BDNF with completed suicide in the Japanese population.
abstract: We explored the association between the brain-derived neurotrophic factor gene with suicide using 307 Japanese completed suicides, 380 healthy controls, and data from previously published samples. The meta-analyses of the valine with methionine in codon 66 (Val66Met) single nucleotide polymorphism (SNP) showed that the Met-allele tended to be associated with attempted suicide in Asian populations, but not with the completed suicide.
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
authors.forename: Woraphat
authors.initials: W
authors.lastname: Ratta-Apha
authors.forename: Akitoyo
authors.initials: A
authors.lastname: Hishimoto
authors.forename: Masakuni
authors.initials: M
authors.lastname: Yoshida
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ueno
authors.forename: Migiwa
authors.initials: M
authors.lastname: Asano
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirakawa
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D015201:Meta-Analysis as Topic; D008715:Methionine / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016728:Self-Injurious Behavior / Q000453:epidemiology / Q000235:genetics*; D013405:Suicide; D014633:Valine / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine
keywords: Association study; Brain-derived neurotrophic factor; Suicide