title: Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes.
abstract: Adipocytes hypertrophy is the main cause of obesity and its affliction such as type 2 diabetes (T2D). Since superparamagnetic iron oxide nanoparticles (SPIONs) are used for a wide range of biomedical/medical applications, we aimed to study the effect of SPIONs on 22 and 29 risk genes (Based on gene wide association studies) for obesity and T2D in human adipocytes. The mRNA expression of lipid and glucose metabolism genes was changed upon the treatment of human primary adipocytes with SPIONs. mRNA of GULP1, SLC30A8, NEGR1, SEC16B, MTCH2, MAF, MC4R, and TMEM195 were severely induced, whereas INSIG2, NAMPT, MTMR9, PFKP, KCTD15, LPL and GNPDA2 were down-regulated upon SPIONs stimulation. Since SEC16B gene assist the phagocytosis of apoptotic cells and this gene were highly expressed upon SPIONs treatment in adipocytes, it is logic to assume that SPIONs may play a crucial role in this direction, which requires more consideration in the future.
authors.affiliation: Department of Biomedical Engineering, W.J. Kolff Institute, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Sharifi
authors.forename: S
authors.initials: S
authors.lastname: Daghighi
authors.forename: M M
authors.initials: MM
authors.lastname: Motazacker
authors.forename: B
authors.initials: B
authors.lastname: Badlou
authors.forename: B
authors.initials: B
authors.lastname: Sanjabi
authors.forename: A
authors.initials: A
authors.lastname: Akbarkhanzadeh
authors.forename: A T
authors.initials: AT
authors.lastname: Rowshani
authors.forename: S
authors.initials: S
authors.lastname: Laurent
authors.forename: M P
authors.initials: MP
authors.lastname: Peppelenbosch
authors.forename: F
authors.initials: F
authors.lastname: Rezaee
mesh_terms: D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D009765:Obesity / Q000235:genetics*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide