title: Volumetric real-time tracking of peripheral human vasculature with GPU-accelerated three-dimensional optoacoustic tomography.
abstract: Optoacoustic tomography provides a unique possibility for ultra-high-speed 3-D imaging by acquiring complete volumetric datasets from interrogation of tissue by a single nanosecond-duration laser pulse. Yet, similarly to ultrasound, optoacoustics is a time-resolved imaging method, thus, fast 3-D imaging implies real-time acquisition and processing of high speed data from hundreds of detectors simultaneously, which presents significant technological challenges. Herein we present a highly efficient graphical processing unit (GPU) framework for real-time reconstruction and visualization of 3-D tomographic optoacoustic data. By utilizing a newly developed 3-D optoacoustic scanner, which simultaneously acquires signals with a handheld 256-element spherical ultrasonic array system, we further demonstrate tracking of deep tissue human vasculature rendered at a rate of 10 volumetric frames per second. The flexibility provided by the handheld hardware design, combined with the real-time operation, makes the developed platform highly usable for both clinical imaging practice and small animal research applications.
authors.forename: X Luis
authors.initials: XL
authors.lastname: Dean-Ben
authors.forename: Ali
authors.initials: A
authors.lastname: Ozbek
authors.forename: Daniel
authors.initials: D
authors.lastname: Razansky
mesh_terms: D003196:Computer Graphics; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D061088:Photoacoustic Techniques / Q000379:methods*