title: Metabolic syndrome and incidence of asthma in adults: the HUNT study.
abstract: Obesity is a risk factor for incident asthma in adults, and obesity is a major component of metabolic syndrome. This study aimed to explore the associations of metabolic syndrome and its components with the cumulative incidence of asthma in adults. We conducted a prospective cohort study of participants who were asthma-free at baseline (n = 23 191) in the Nord-Trøndelag Health Study from 1995 to 2008. Baseline metabolic syndrome was categorised using the definition of the Joint Interim Statement from several international organisations. Incident asthma was self-reported at follow-up, which averaged 11 years. Metabolic syndrome was a risk factor for incident asthma (adjusted OR 1.57, 95% CI 1.31-1.87). This association was consistent in sensitivity analyses using a stricter asthma definition (adjusted OR 1.42, 95% CI 1.13-1.79). Among the components of metabolic syndrome, two remained associated with incident asthma after mutual adjustment for the other metabolic components: high waist circumference (adjusted OR 1.62, 95% CI 1.36-1.94) and elevated glucose or diabetes (adjusted OR 1.43, 95% CI 1.01-2.04). Metabolic syndrome and two of its components (high waist circumference and elevated glucose or diabetes) were associated with an increased risk of incident asthma in adults.
authors.affiliation: Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Ben Michael
authors.initials: BM
authors.lastname: Brumpton
authors.forename: Carlos Arturo
authors.initials: CA
authors.lastname: Camargo
authors.forename: Pål Richard
authors.initials: PR
authors.lastname: Romundstad
authors.forename: Arnulf
authors.initials: A
authors.lastname: Langhammer
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Mai
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications* / Q000453:epidemiology; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose