title: Inflammatory myofibroblastic tumor: a rapidly growing soft tissue mass in the posterior mandible.
abstract: The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. Head and neck IMTs are rarely seen and comprise less than 5 % of tumors. Here we report a case of a 30 year old male who presented with a rapidly enlarging and extremely painful growth in the right posterior mandible, post extraction. Histopathological examination revealed a highly cellular connective tissue stroma comprised of spindle shaped cells arranged in fascicles, admixed with inflammatory cells, predominantly plasma cells. Apart from routine hematological investigations, serum protein electrophoresis was also performed. The final diagnosis was confirmed by a panel of immunomarkers consisting of MPO, CD34, CD20, CD3, CD23, CD138, SMA and ALK. To the best of our knowledge, this is the third case of oral IMT arising from an extraction socket.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Manipal College of Dental Sciences, Manipal University, Manipal, 576104, Karnataka, India.
authors.forename: Parul
authors.initials: P
authors.lastname: Sah
authors.forename: Aditi Amit
authors.initials: AA
authors.lastname: Byatnal
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Rao
authors.forename: Venkadasalapathy
authors.initials: V
authors.lastname: Narayanaswamy
authors.forename: Raghu
authors.initials: R
authors.lastname: Radhakrishnan
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D018450:Disease Progression; D006104:Granuloma, Plasma Cell / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D008297:Male; D008336:Mandibular Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor