title: Effects of osmotic pressure on intrathecal and epidural lidocaine anesthesia.
abstract: Lidocaine (1%), either in plain distilled water or in 10% dextrose, was intrathecally or epidurally administered to urethane-chloralose anesthetized cats. Electrical stimulation was applied to the gracile tract at a cervical level, and the resultant antidromic compound action potentials were recorded from the sural nerve. Lidocaine dissolved in plain distilled water was more effective than lidocaine dissolved in 10% dextrose solution in suppressing the compound action potentials. Lidocaine-free plain distilled water or dextrose solution caused partial suppression of the compound action potentils. The suppression was more marked following plain distilled water application than following application of 5% or 10% dextrose.
authors.affiliation: Department of Anesthesiology, Shiga University of Medical Science, Seta, 520-21, Otsu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Minami
authors.forename: N
authors.initials: N
authors.lastname: Koyama
authors.forename: Y
authors.initials: Y
authors.lastname: Amakata