title: A case of myxoid liposarcoma of the breast.
abstract: A 70-year-old woman visited a local hospital complaining of a nodulein the right breast, present since 1 month. She was referred to our hospital for further evaluation. Following mammotome (MMT) biopsy, the nodule was diagnosed as myxoid/round cell liposarcoma. She underwent total mastectomy of the right breast. Histological analysis indicated that the tumor was almost entirely composed of proliferating small round mesenchymal cells in amyxoid matrix background with capillary-like vessels with partial necrosis (<10%). Immunohistochemically, p53 positive cells were seen focally (<1%) only, and the Ki-67 labeling index was approximately 20%. Since the surgical margin was histologically positive despite pathologic findings of high-grade malignancy, adjuvant treatment involving local radiation therapy (60Gy) was administered. The patient was free from any symptoms of local recurrence and metastases 1 year and 8 months after surgery.
authors.affiliation: Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan. tysaitou@juntendo.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saito
authors.forename: Misa
authors.initials: M
authors.lastname: Ryu
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fukumura
authors.forename: Miki
authors.initials: M
authors.lastname: Asahina
authors.forename: Atsushi
authors.initials: A
authors.lastname: Arakawa
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nakai
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Miura
authors.forename: Mitsue
authors.initials: M
authors.lastname: Saito
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D018208:Liposarcoma, Myxoid / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008408:Mastectomy; D018365:Neoplasm, Residual; D011237:Predictive Value of Tests; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D016217:Ultrasonography, Mammary
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
keywords: Myxoid liposarcoma; breast; round cell component