title: Development: Hippo signalling turns the embryo inside out.
abstract: Lineage decisions in development are thought to be primarily due to differential activation of transcription factors. However, cell position and subcellular organization of signalling also play a role. New studies of the Hippo pathway in the early mouse embryo show how.
authors.affiliation: Cardiovascular Development and Repair Department, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. mmanzanares@cnic.es
authors.forename: Miguel
authors.initials: M
authors.lastname: Manzanares
authors.forename: Tristan A
authors.initials: TA
authors.lastname: Rodriguez
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000091082:Angiomotins; D000818:Animals; D001755:Blastocyst / Q000378:metabolism*; D018797:Cell Cycle Proteins; D016764:Cell Polarity; D018507:Gene Expression Regulation, Developmental; D000090683:Hippo Signaling Pathway; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008840:Microfilament Proteins / Q000235:genetics*; D025581:Neurofibromin 2 / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D015398:Signal Transduction; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C511047:Amot protein, mouse; D000091082:Angiomotins; D018797:Cell Cycle Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008840:Microfilament Proteins; D025581:Neurofibromin 2; D010750:Phosphoproteins; D000091102:YAP-Signaling Proteins; C486223:Yap1 protein, mouse; D017346:Protein Serine-Threonine Kinases