title: Piecing together the extracellular puzzle.
abstract: Large-scale screens to identify protein interactions typically underperform with eukaryotic extracellular proteins. In this issue, Özkan et al. report development of a high-throughput assay designed specifically for extracellular proteins that uncovers a wealth of new interactions among three protein superfamilies in Drosophila and sets the stage for more extensive screens.
authors.affiliation: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. dleahy@jhmi.edu
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Leahy
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology* / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D007136:Immunoglobulins / Q000378:metabolism*; D000090263:Leucine-Rich Repeat Proteins; D060066:Protein Interaction Maps; D011506:Proteins / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D005353:Fibronectins; D007136:Immunoglobulins; D000090263:Leucine-Rich Repeat Proteins; D011506:Proteins