title: A modified cyclen azaxanthone ligand as a new fluorescent probe for Zn2+.
abstract: A new cyclen derivative L, bearing a methyl-chromeno-pyridinylidene hydrazone moiety, was synthesized and studied in MeOH, as potential fluorescent "OFF-on-ON" sensors for Zn(ii). Photophysical properties of this ligand being PET regulated, L was only weakly emissive in the absence of metal ions (OFF). L fluorescence was increased modestly upon addition of one equivalent of Zn(II), and further increased upon addition of a second equivalent. Therefore, Zn : L behaved as a highly sensitive ON sensor for zinc. This efficiency was correlated to Zn(II) coordination via the hydrazone moiety of the fluorophore, producing an efficient CHelation-Enhanced Fluorescence (CHEF) effect. A complementary theoretical study carried out with DFT calculations further elucidated the optical properties.
authors.affiliation: Université Reims Champagne-Ardenne - Institut de Chimie Moléculaire de Reims, CNRS UMR n° 7312, Groupe Chimie de Coordination, UFR Sciences, BP 1039, 51687 Reims Cedex 2, France.
authors.forename: Hela
authors.initials: H
authors.lastname: Nouri
authors.forename: Cyril
authors.initials: C
authors.lastname: Cadiou
authors.forename: Latévi Max
authors.initials: LM
authors.lastname: Lawson-Daku
authors.forename: Andreas
authors.initials: A
authors.lastname: Hauser
authors.forename: Sylviane
authors.initials: S
authors.lastname: Chevreux
authors.forename: Isabelle
authors.initials: I
authors.lastname: Déchamps-Olivier
authors.forename: Fabien
authors.initials: F
authors.lastname: Lachaud
authors.forename: Riadh
authors.initials: R
authors.lastname: Ternane
authors.forename: Malika
authors.initials: M
authors.lastname: Trabelsi-Ayadi
authors.forename: Françoise
authors.initials: F
authors.lastname: Chuburu
authors.forename: Gilles
authors.initials: G
authors.lastname: Lemercier
mesh_terms: D000080027:Cyclams; D005456:Fluorescent Dyes / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D008024:Ligands; D011789:Quantum Theory; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000032:analysis*
chemical_list: D000080027:Cyclams; D005456:Fluorescent Dyes; D006571:Heterocyclic Compounds; D007477:Ions; D008024:Ligands; C038072:cyclen; D015032:Zinc