title: Effect of High-Intensity interval training versus moderate continuous training on 24-h blood pressure profile and insulin resistance in patients with chronic heart failure.
abstract: In patients with chronic heart failure (CHF) blood pressure (BP) control, represents a relevant target of management. This study evaluated the effect of different intensities exercise training on 24-h ambulatory BP profile and insulin resistance in patients with CHF. Thirty-six CHF patients with left ventricular ejection fraction <40%, were randomized to high-intensity interval training (HIT) or moderate continuous training (MIT) for 12 weeks. HIT consisted in treadmill exercise at ~75-80% of heart rate reserve (HRR), alternated with active pauses at 45-50% of HRR. MIT consisted in continuous treadmill at ~45-60% of HRR. Peak VO2 and anaerobic threshold increased significantly with both HIT and MIT, without significant differences between the two training programs. 24-h, systolic and diastolic BP decreased with both HIT and MIT. The same occurred for day-time and night-time systolic and diastolic BP. The decrease in day-time diastolic BP was slightly but significantly greater in HIT. Both HIT and MIT induced a significant decrease in fasting glucose and insulin, whereas HOMA-IR decreased significantly only after HIT. In patients with CHF exercise training reduces BP throughout the day, without substantial differences between moderate and more vigorous exercise intensity, with a small exception for day-time diastolic BP. HIT was more effective in improving insulin resistance.
authors.affiliation: Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Pisana, Rome, Italy, iellamo@med.uniroma2.it.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Iellamo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Caminiti
authors.forename: Barbara
authors.initials: B
authors.lastname: Sposato
authors.forename: Cristiana
authors.initials: C
authors.lastname: Vitale
authors.forename: Michele
authors.initials: M
authors.lastname: Massaro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rosano
authors.forename: Maurizio
authors.initials: M
authors.lastname: Volterrani
mesh_terms: D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002908:Chronic Disease; D015444:Exercise; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D008297:Male