title: Effect of beta-tricalcium phosphate/poly-l-lactide composites on radial bone defects of rabbit.
abstract: OBJECTIVE
  To explore the effect ofβ-TCP/PLLA scaffold in repairing rabbit radial bone defects.
  
  
  METHODS
  Thirty New Zealand rabbits were divided into β-TCP /PLLA group (group A), pure PLLA group (group B) and contrast group (group C) randomly. The rabbits were sacrificed respectively after 4, 8, 12, 24 weeks and the X-ray film was performed at the same time to evaluate the repair effect in different groups.
  
  
  RESULTS
  X-ray film showed there was uneven low density bone callus development in defect region after 4 weeks in group A. The defect region was filled with neonate osseous tissue completely during 12-24 weeks. X-ray score revealed that repair of bone defect results significantly better than group B and group C.
  
  
  CONCLUSIONS
  The β-TCP /PLLA composite is capable of repairing radial bone bone defects. β-TCP/PLLA scaffold is significant because of rapid degradation ability, good histocompatibility and osteogenic action.
authors.affiliation: Medical Board of Graduate School of Suzhou University, Suzhou 215000, Jiangsu, China.
authors.forename: Zhao-Jin
authors.initials: ZJ
authors.lastname: Zhu
authors.forename: Hao
authors.initials: H
authors.lastname: Shen
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Yao
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xian-Long
authors.initials: XL
authors.lastname: Zhang
authors.forename: Guang-Yin
authors.initials: GY
authors.lastname: Yuan
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density; D001847:Bone Diseases / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D006801:Humans; D008297:Male; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011817:Rabbits; D011884:Radius / Q000002:abnormalities* / Q000503:physiopathology; D023822:Tissue Engineering / Q000295:instrumentation; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D011091:Polyesters; D011108:Polymers; C485817:beta-tricalcium phosphate; C033616:poly(lactide)
keywords: Bone defect; Large segment of simulated-bioactive bone substitute; β-TCP/ PLLA