title: Serum levels of N-terminal proB-type natriuretic peptide in mechanically ventilated critically ill patients--relation to tidal volume size and development of acute respiratory distress syndrome.
abstract: BACKGROUND
  Serum levels of N-terminal proB-type natriuretic peptide (NT-proBNP) are elevated in patients acute respiratory distress syndrome (ARDS). Recent studies showed a lower incidence of acute cor pulmonale in ARDS patients ventilated with lower tidal volumes. Consequently, serum levels of NT-proBNP may be lower in these patients. We investigated the relation between serum levels of NT-proBNP and tidal volumes in critically ill patients without ARDS at the onset of mechanical ventilation.
  
  
  METHODS
  Secondary analysis of a randomized controlled trial of lower versus conventional tidal volumes in patients without ARDS. NT-pro BNP were measured in stored serum samples. Serial serum levels of NT-pro BNP were analyzed controlling for acute kidney injury, cumulative fluid balance and presence of brain injury. The primary outcome was the effect of tidal volume size on serum levels of NT-proBNP. Secondary outcome was the association with development of ARDS.
  
  
  RESULTS
  Samples from 150 patients were analyzed. No relation was found between serum levels of NT-pro BNP and tidal volume size. However, NT-proBNP levels were increasing in patients who developed ARDS. In addition, higher levels were observed in patients with acute kidney injury, and in patients with a more positive cumulative fluid balance.
  
  
  CONCLUSIONS
  Serum levels of NT-proBNP are independent of tidal volume size, but are increasing in patients who develop ARDS.
authors.affiliation: Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands. r.m.determann@amc.uva.nl
authors.forename: Rogier M
authors.initials: RM
authors.lastname: Determann
authors.forename: Annick A N M
authors.initials: AA
authors.lastname: Royakkers
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Schaefers
authors.forename: Anita M
authors.initials: AM
authors.lastname: de Boer
authors.forename: Jan M
authors.initials: JM
authors.lastname: Binnekade
authors.forename: Jan P
authors.initials: JP
authors.lastname: van Straalen
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Schultz
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016638:Critical Illness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D013990:Tidal Volume / Q000502:physiology*; D014882:Water-Electrolyte Balance
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain