title: Sirtuins as therapeutic targets of ALS.
abstract: Sirtuins have received a lot of attention in biological functions associated with metabolism, survival development, and most recently, neurodegeneration. The versatile role of sirtuins can be readily redirected for drug discovery studies for novel treatment in amyotrophic lateral sclerosis (ALS), as presented in this highlight, by sirtuin-mediated ketogenic responses influencing mitochondrial function.
authors.affiliation: Department of Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, Annenberg Building, Room 20-02, New York, NY 10029, USA. Giulio.Pasinetti@mssm.edu
authors.forename: Giulio Maria
authors.initials: GM
authors.lastname: Pasinetti
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Bilski
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D000077185:Resveratrol; D037761:Sirtuins / Q000187:drug effects / Q000378:metabolism*; D013267:Stilbenes / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D013267:Stilbenes; D037761:Sirtuins; D000077185:Resveratrol