title: Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice.
abstract: OBJECTIVE
  To evaluate the effects of allopurinol and febuxostat on depression using Forced Swim Test (FST) in mice.
  
  
  METHODS
  Allopurinol (39 mg/kg p. o) and febuxostat (15.6 mg/kg p. o) were administered once daily for 21 successive days to Swiss Albino mice. On the 21(st) day, the effect of the drug on locomotion was tested using photo-actometer followed by the recording of immobility period in the FST and the results were compared with the standard drug fluoxetine (10 mg/kg p. o).
  
  
  RESULTS
  Allopurinol and febuxostat expressed significant antidepressant like effect as indicated by reduction in the immobility period of mice in the FST as compared to control group. The effects of allopurinol and febuxostat were found to be comparable to that of fluoxetine.
  
  
  CONCLUSIONS
  The results of the present study indicate that allopurinol and febuxostat possess significant antidepressant like activity.
authors.affiliation: Department of Pharmacology, T.N. Medical College and B.Y.L. Nair Ch. Hospital, Mumbai, Maharashtra, India.
authors.forename: Ashwini V
authors.initials: AV
authors.lastname: Karve
authors.forename: Sagar S
authors.initials: SS
authors.lastname: Jagtiani
authors.forename: Kunal A
authors.initials: KA
authors.lastname: Chitnis
mesh_terms: D000493:Allopurinol / Q000008:administration & dosage*; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D004195:Disease Models, Animal; D004338:Drug Combinations; D000069465:Febuxostat; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013550:Swimming; D013844:Thiazoles / Q000008:administration & dosage*
chemical_list: D000928:Antidepressive Agents; D004338:Drug Combinations; D013844:Thiazoles; D000069465:Febuxostat; D000493:Allopurinol
keywords: Forced swim test; photo-actometer; serotonin; tryptophan