title: Agarofuran sesquiterpenes from Schaefferia argentinensis.
abstract: Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis Speg. Their structures were determined by a combination of 1D and 2D NMR and MS techniques. The in vitro antiproliferative activity of the major sesquiterpenes was examined in T47D, MCF7, and MDA-MB231 human cancer cell lines, but was found to be marginal.
authors.affiliation: Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Universidad Nacional de Córdoba, 5000 Córdoba, Argentina.
authors.forename: Manuela E
authors.initials: ME
authors.lastname: García
authors.forename: Rubén D
authors.initials: RD
authors.lastname: Motrich
authors.forename: Beatriz L
authors.initials: BL
authors.lastname: Caputto
authors.forename: Marianela
authors.initials: M
authors.lastname: Sánchez
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Palermo
authors.forename: Ana
authors.initials: A
authors.lastname: Estévez-Braun
authors.forename: Angel G
authors.initials: AG
authors.lastname: Ravelo
authors.forename: Viviana E
authors.initials: VE
authors.lastname: Nicotra
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029753:Celastraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C079978:dihydroagarofuran
keywords: Antiproliferative activity; Celastraceae; Dihydro-β-agarofuran sesquiterpene; Phytochemistry; Schaefferia argentinensis