title: Highly oxygenated meroterpenoids from fruiting bodies of the mushroom Tricholoma terreum.
abstract: Four new meroterpenoids, terreumols A-D (1-4), with a rare 10-membered ring system, were isolated from the fruiting bodies of Tricholoma terreum. Their structures with absolute stereochemistry were determined by comprehensive spectroscopic methods, as well as single-crystal X-ray diffractions. Compounds 1, 3, and 4 were evaluated for their cytotoxicities against five human cancer cell lines; all of them exhibited inhibitory effects, with IC50 values comparable to those of cisplatin.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yin
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Ji Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D000363:Agaricales / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005602:France; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010100:Oxygen / Q000032:analysis; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D055439:Tricholoma / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes; C584225:terreumol A; C584226:terreumol C; C584227:terreumol D; D010100:Oxygen