title: Cargo trafficking between endosomes and the trans-Golgi network.
abstract: The retrograde membrane transport pathways from endosomes to the trans-Golgi network (TGN) are now recognized as critical intracellular pathways to recycle and shuttle a selective subgroup of membrane proteins, including sorting receptors, membrane-bound enzymes, transporters, as well as providing an avenue for the intracellular transport of various bacterial toxins. Multiple pathways from endosomes to the TGN have now been defined which differ between the cargo transported and the machinery used. Here, we review advances in these pathways and the requirement for TGN organization, and also discuss the development of unbiased analytical approaches to quantitatively track cargo that use these endosome-to-TGN pathways.
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
authors.forename: Pei Zhi Cheryl
authors.initials: PZ
authors.lastname: Chia
authors.forename: Priscilla
authors.initials: P
authors.lastname: Gunn
authors.forename: Paul A
authors.initials: PA
authors.lastname: Gleeson
mesh_terms: D000818:Animals; D001692:Biological Transport; D011992:Endosomes / Q000378:metabolism*; D021601:trans-Golgi Network / Q000378:metabolism*