title: Is there any relationship between Le(b) antigen expression and Helicobacter pylori infection?
abstract: BACKGROUND
  Helicobacter pylori infection is one of the main causes of peptic ulcer. There are some blood groups acting as receptors for the pathogen. Based on this view and previous attempts, we tried to examine the relationship between Lewis blood group and H. pylori infection.
  
  
  METHODS
  Blood and saliva samples were collected from 60 patients with established peptic ulcer induced by H. pylori. Secretory status of each patient was determined by both direct agglutination and saliva tests.
  
  
  RESULTS
  Seventy-two percent of the patients were secretor and expressed Lewis B antigen. This rate in control group was 61%. Statistical analysis showed no significant difference between the two groups.
  
  
  CONCLUSIONS
  This study did not find any correlation between Le(b) antigen expression and presence of H. pylori-induced peptic ulcer. It is now recommended that other factors like Lewis(x) and sialyl Lewis(x) should be investigated in binding, colonization and virulence of H. pylori infection in the future.
authors.affiliation: Molecular and Cellular Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Mahdavi
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Amami
authors.forename: Tarang
authors.initials: T
authors.lastname: Taghvaie
authors.forename: Payam
authors.initials: P
authors.lastname: Roshan
authors.forename: Mohammad Taher
authors.initials: MT
authors.lastname: Hojjati
authors.forename: Mehrad
authors.initials: M
authors.lastname: Mahdavi
authors.forename: Vahid
authors.initials: V
authors.lastname: Hoseini
mesh_terms: D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000502:physiology; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000276:immunology; D008297:Male; D009844:Oligosaccharides / Q000276:immunology*; D010437:Peptic Ulcer / Q000276:immunology / Q000382:microbiology
chemical_list: D007983:Lewis Blood Group Antigens; D009844:Oligosaccharides; C404741:galactopyranosyl-1-3-galactopyranosyl-1-3(4)-N-acetylglucosamine
keywords: Antigen expression; H. pylori; Lewis B blood group; Minor blood group