title: Distress calls of the greater short-nosed fruit bat Cynopterus sphinx activate hypothalamic-pituitary-adrenal (HPA) axis in conspecifics.
abstract: In a stressful situation, greater short-nosed fruit bats (Cynopterus sphinx) emit audible vocalization either to warn or to inform conspecifics. We examined the effect of distress calls on bats emitting the call as well as the bats receiving the distress signal through analysis of the hypothalamic-pituitary-adrenal axis and catacholaminargic systems. We measured the levels of neurotransmitters [serotonin (5-HT), dopamine (DA), norepinephrine (NE)] and stress hormones [(adrenocorticotropic hormone (ACTH) and corticosterone (CORT)]. Our results showed that distress call emission elevated the level of ACTH and CORT, as well as 5-HT, DA and NE in the amygdala, for both the call emitting bat and the responding bat. Subsequently, we observed increased activity of glucocorticoid receptor and its steroid receptor co-activator (SRC-1). An expression of SRC-1 was up-regulated in the distress call emitter only, whereas it was at a similar level in both the call responder and silent bats. These findings suggest that bats emitting distress calls and also bats responding to such calls have similar neurotransmitter expression patterns, and may react similarly in response to stress.
authors.affiliation: Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620024, India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Mariappan
authors.forename: Wieslaw
authors.initials: W
authors.lastname: Bogdanowicz
authors.forename: Ganapathy
authors.initials: G
authors.lastname: Marimuthu
authors.forename: Koilmani Emmanuvel
authors.initials: KE
authors.lastname: Rajan
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000679:Amygdala / Q000378:metabolism; D000818:Animals; D002685:Chiroptera / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000502:physiology* / Q000523:psychology; D003345:Corticosterone / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005239:Fear; D005786:Gene Expression Regulation; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D056920:Nuclear Receptor Coactivator 1 / Q000235:genetics / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D013312:Stress, Physiological; D014828:Vocalization, Animal
chemical_list: D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D012701:Serotonin; D000324:Adrenocorticotropic Hormone; D056920:Nuclear Receptor Coactivator 1; D004298:Dopamine; D003345:Corticosterone; D009638:Norepinephrine