title: The adjunctive digital breast tomosynthesis in diagnosis of breast cancer.
abstract: OBJECTIVE
  To compare the diagnostic performance of digital breast tomosynthesis (DBT) and digital mammography (DM) for breast cancers.
  
  
  METHODS
  Fifty-seven female patients with pathologically proved breast cancer were enrolled. Three readers gave a subjective assessment superiority of the index lesions (mass, focal asymmetry, architectural distortion, or calcifications) and a forced BIRADS score, based on DM reading alone and with additional DBT information. The relevance between BIRADS category and index lesions of breast cancer was compared by chi-square test.
  
  
  RESULTS
  A total of 59 breast cancers were reviewed, including 17 (28.8%) mass lesions, 12 (20.3%) focal asymmetry/density, 6 (10.2%) architecture distortion, 23 (39.0%) calcifications, and 1 (1.7%) intracystic tumor. Combo DBT was perceived to be more informative in 58.8% mass lesions, 83.3% density, 94.4% architecture distortion, and only 11.6% calcifications. As to the forced BIRADS score, 84.4% BIRADS 0 on DM was upgraded to BIRADS 4 or 5 on DBT, whereas only 27.3% BIRADS 4A on DM was upgraded on DBT, as BIRADS 4A lesions were mostly calcifications. A significant P value (<0.001) between the BIRADS category and index lesions was noted.
  
  
  CONCLUSIONS
  Adjunctive DBT gives exquisite information for mass lesion, focal asymmetry, and/or architecture distortion to improve the diagnostic performance in mammography.
authors.affiliation: Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.
authors.forename: Tsung-Lung
authors.initials: TL
authors.lastname: Yang
authors.forename: Huei-Lung
authors.initials: HL
authors.lastname: Liang
authors.forename: Chen-Pin
authors.initials: CP
authors.lastname: Chou
authors.forename: Jer-Shyung
authors.initials: JS
authors.lastname: Huang
authors.forename: Huay-Ben
authors.initials: HB
authors.lastname: Pan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D003710:Demography; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged