title: Topical Mitomycin C application for esophageal stricture: safe, precise, and novel endoscopic technique.
abstract: OBJECTIVE
  The first line of management of benign esophageal stricture is endoscopic dilatation; however, multiple sessions are usually indicated especially in resistant cases. Topical Mitomycin C (MCC) application is a new adjuvant treatment in the management of esophageal stricture with promising results in different case series. Several techniques have been reported for application; nevertheless, the ideal technique has not been described yet.
  
  
  METHODS
  In this series we have devised a new technique using both the flexible and the rigid endoscope and a specially designed Nelaton catheter.
  
  
  RESULTS
  This technique was applied in 38 sessions for 16 caustic esophageal strictures with technical success in all cases. No procedure-related complications were observed in this series.
  
  
  CONCLUSIONS
  This novel technique is feasible and effective and can be considered as standard for topical MMC application on esophageal stricture.
authors.affiliation: Pediatric Surgery Department, Ain Shams University, Cairo, Egypt. khaled80@hotmail.com
authors.forename: Khaled Mohamed
authors.initials: KM
authors.lastname: El-Asmar
mesh_terms: D000287:Administration, Topical; D000477:Alkylating Agents / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D057785:Catheters; D002648:Child; D003131:Combined Modality Therapy; D004106:Dilatation / Q000295:instrumentation / Q000379:methods*; D004940:Esophageal Stenosis / Q000139:chemically induced / Q000188:drug therapy / Q000628:therapy*; D020701:Esophagoscopes; D004945:Esophagoscopy / Q000295:instrumentation / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D016685:Mitomycin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin
keywords: Endoluminal drug delivery; Endoscopic dilatation; Esophageal stricture; MMC; Mitomycin C; Mitomycin C application technique