title: Par(-4)oxysm in breast cancer.
abstract: Women suffering from breast cancer often succumb to incurable recurrent disease resulting from therapy-resistant cancer cells. In this issue of Cancer Cell, Alvarez and colleagues identify downregulation of the tumor suppressor Par-4 as the key determinant in apoptosis evasion, which leads to tumor recurrence in breast cancer.
authors.affiliation: Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40508, USA.
authors.forename: Tripti
authors.initials: T
authors.lastname: Shrestha-Bhattarai
authors.forename: Nikhil
authors.initials: N
authors.lastname: Hebbar
authors.forename: Vivek M
authors.initials: VM
authors.lastname: Rangnekar
mesh_terms: D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000502:physiology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D025521:Tumor Suppressor Proteins / Q000502:physiology*
chemical_list: D051017:Apoptosis Regulatory Proteins; D025521:Tumor Suppressor Proteins; C101296:prostate apoptosis response-4 protein