title: Carotid intima-media thickness and plaque in apparently healthy Japanese individuals with an estimated 10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) guidelines 2012: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).
abstract: OBJECTIVE
  To examine whether subclinical atherosclerosis of the carotid arteries is concordant with the categories in the 2012 atherosclerosis prevention guidelines proposed by the Japan Atherosclerosis Society (JAS guidelines 2012), which adopted the estimated 10-year absolute risk of coronary artery disease (CAD) death in the NIPPON DATA80 Risk Assessment Chart.
  
  
  METHODS
  Between 2006 and 2008, 868 Japanese men 40 to 74 years of age without a history of cardiovascular disease were randomly selected from Kusatsu City, Japan. The intima media thickness (IMT) and plaque number from the common to internal carotid arteries were investigated using ultrasonography. The absolute risk of CAD death was estimated based on the individual risk factor data, and the mean IMT and plaque number in Categories Ⅰ, Ⅱ and Ⅲ of the guidelines were examined.
  
  
  RESULTS
  The estimated 10-year absolute risk of CAD was directly related to the IMT (mean IMT (mean ± SD) (mm) for a 10-year absolute risk of ≥ 2.0% and ≥ 5.0%: 0.88 ± 0.18 and 0.95 ± 0.19, respectively) and the plaque number. These results are compatible with the categories described by the guidelines (mean IMT (mean ± SD) (mm) for Categories Ⅰ, Ⅱ, and Ⅲ: 0.70 ± 0.11, 0.81 ± 0.16 and 0.88 ± 0.18, respectively; mean plaque number: 0.9, 2.1 and 3, respectively). These findings were similar for Category Ⅲ participants with or without DM and CKD.
  
  
  CONCLUSIONS
  Subclinical atherosclerosis of the carotid arteries is concordant with the 10-year absolute risk of CAD and the categories in the JAS guidelines 2012.
authors.affiliation: Department of Health Science, Shiga University of Medical Science.
authors.forename: Aya
authors.initials: A
authors.lastname: Kadota
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miura
authors.forename: Tomonori
authors.initials: T
authors.lastname: Okamura
authors.forename: Akira
authors.initials: A
authors.lastname: Fujiyoshi
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Takashima
authors.forename: Takashi
authors.initials: T
authors.lastname: Hisamatsu
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Kasagi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maegawa
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000473:pathology; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic; D012307:Risk Factors; D017539:Tunica Intima / Q000033:anatomy & histology*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human