title: [Dyspnoea, cough and B symptoms in a 40-year-old woman].
abstract: Multicentric Castleman's disease (MCD) is a rare polyclonal lymphoproliferative disorder that is typically accompanied by an overproduction of circulating cytokines (mainly interleukin-6). We here report the case of a 40-year-old HIV-negative woman with pulmonary manifestation of MCD. There is no standard treatment for MCD. In our patient, various treatment courses with immunomodulatory drugs were unsuccessful. Finally, treatment with the interleukin-6 receptor antibody tocilizumab has resulted in continual clinical improvement over the last 5 years.
authors.affiliation: Klinik für Infektionskrankheiten und Spitalhygiene, UniversitätsSpital Zürich, Zürich, Schweiz.
authors.forename: A
authors.initials: A
authors.lastname: Wolfensberger
authors.forename: R
authors.initials: R
authors.lastname: Benz
authors.forename: E W
authors.initials: EW
authors.lastname: Russi
authors.forename: M
authors.initials: M
authors.lastname: Tinguely
authors.forename: C
authors.initials: C
authors.lastname: Keller
authors.forename: B
authors.initials: B
authors.lastname: Gerber
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D005871:Castleman Disease / Q000175:diagnosis* / Q000188:drug therapy*; D003371:Cough / Q000175:diagnosis* / Q000188:drug therapy*; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C502936:tocilizumab