title: Isolated cortical vein thrombosis associated with prothrombin gene mutation.
abstract: Isolated cortical vein thrombosis (ICVT) accounts for less than 1% of strokes. We report a 47-year-old female patient who had a frontal hemorrhage with headache associated with contralateral hemiparesis and hemisensory deficit on presentation. This hemorrhagic stroke was localized in a nonarterial territory, and it was caused by ipsilateral and isolated thrombosis of the vein of Labbe found on catheter angiogram that demonstrated a filling defect of the vein of Labbe at its connection with the transverse sinus. There were no filling defects in the superficial middle cerebral veins. Our patient had a family history of cardiovascular disease, stroke, and factor V Leiden mutation and cigarette smoking as stroke risk factors. Complete prothrombotic state laboratory workup revealed a heterozygous prothrombin G20210 A gene mutation. The patient's hospital course was uneventful. Neurologic exam was normal at stroke clinic follow-up 6 weeks later. To our knowledge, this is the first report of an ICVT associated with prothrombin gene mutation.
authors.affiliation: Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania. Electronic address: elias.giraldo@drexelmed.edu.
authors.forename: Elias A
authors.initials: EA
authors.lastname: Giraldo
authors.affiliation: Department of Radiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
authors.forename: Rohan
authors.initials: R
authors.lastname: Arora
authors.affiliation: Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Koenigsberg
mesh_terms: D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000235:genetics; D020767:Intracranial Thrombosis / Q000150:complications / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009460:Neurologic Examination; D011516:Prothrombin / Q000235:genetics*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000235:genetics*
chemical_list: D011516:Prothrombin
keywords: Hemorrhagic stroke; cortical vein thrombosis; inherited thrombophilia; prothrombin G20210A gene mutation