title: The healing effect of shark cartilage in rabbits after colonic anastomosis.
abstract: OBJECTIVE
  Shark cartilage has anti-inflammatory, analgesic, anti-angiogenic, anti-tumoral, and immunomodulatory properties. We studied the effect of shark cartilage on the healing of colonic anastomoses, which are among the gastrointestinal system anastomoses that most commonly cause leakage.
  
  
  METHODS
  Rabbits were divided into two groups of seven as the study and control groups. A normal diet was given to both groups before and after right colonic anastomosis. Shark cartilage tablets were given orally to the study group for five days before and after the anastomosis. Bursting pressures, hydroxyproline levels and translocation of the intestinal flora in anastomosis region were evaluated on the 6th day by operating on both groups.
  
  
  RESULTS
  Bursting pressure and hydroxproline levels were higher in the experimental group compared to the control group (p<0.05). An increase in connective tissue and vascularization without growth of microorganisms was observed in the experimental group on microbiological examination.
  
  
  CONCLUSIONS
  Shark cartilage given orally to rabbits increased anastomotic healing and did not cause serious consequences such as bacterial translocation.
authors.forename: Barlas
authors.initials: B
authors.lastname: Sulu
authors.forename: Mete
authors.initials: M
authors.lastname: Cihan
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Gunerhan
authors.forename: Mahmut
authors.initials: M
authors.lastname: Sozmen
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000601:surgery*; D011817:Rabbits; D014020:Tissue Extracts / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D014020:Tissue Extracts; C111481:shark cartilage extract
keywords: Anastomosis, Colon, Rabbits shark cartilage, Surgery.