title: [Aristolochic acid nephropathy: an issue worth more attention].
abstract: Aristolochic acid nephropathy (AAN), a progressive renal interstitial fibrosis frequently resulting in end stage renal disease, still remains a common chronic interstitial nephropathy in China. Therefore, great attention should be paid to AAN. This review summarized recent research progress of AAN in terms of in vivo aristolochic acid metabolism, epithelial mesenchymal transition, proteomics, immunity-inflammation, and autophagy, which will help to further understand the pathogenesis of AAN, and to search effective intervention targets.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Lab of Chinical Research on Nepropathy, Ministry of Health, Guangzhou 510080, China.
authors.forename: Xin-hui
authors.initials: XH
authors.lastname: Liu
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D034341:Aristolochic Acids / Q000009:adverse effects* / Q000378:metabolism; D001343:Autophagy; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D007249:Inflammation; D007674:Kidney Diseases / Q000139:chemically induced*; D040901:Proteomics
chemical_list: D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; C000228:aristolochic acid I