title: Emerging role of the scaffolding protein Dlg1 in vesicle trafficking.
abstract: Discs large 1 (Dlg1) is a modular scaffolding protein implicated in the control of cell polarity through assembly of specific multiprotein complexes, including receptors, ion channels and signaling proteins, at specialized zones of the plasma membrane. Recent data have shown that in addition to these well-known interaction partners, Dlg1 may also recruit components of the vesicle trafficking machinery either to the plasma membrane or to transport vesicles. Here, we discuss Dlg1 function in vesicle formation, targeting, tethering and fusion, in both the exocytotic and endocytotic pathways. These pathways contribute to cell functions as major and diverse as glutamatergic activity in the neurons, membrane homeostasis in Schwann cell myelination, insulin stimulation of glucose transport in adipocytes, or endothelial secretion of the hemostatic protein, von Willebrand factor (VWF).
authors.affiliation: INSERM U698, Université Paris 7, Hemostasis, Bio-engineering and Cardiovascular Remodeling, CHU X. Bichat, Paris, France. laurence.walch@inserm.fr
authors.forename: Laurence
authors.initials: L
authors.lastname: Walch
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D008565:Membrane Proteins; D033921:Vesicular Transport Proteins
keywords: Dlg1; SAP-97; endocytosis; exocytosis; polarized trafficking; protein sorting; scaffolding proteins; trafficking machinery