title: Prognosis of patients treated for Cushing syndrome.
abstract: Cushing syndrome (CS), due to an ACTH-secreting pituitary adenoma, adrenal tumors, or ectopic ACTH secretion, causes hypercortisolism. CS is associated with major morbidity, especially metabolic and cardiovascular complications, osteoporosis, psychiatric changes, and cognitive impairment. Despite biochemical "cure" of hypercortisolism and clinical improvement after effective treatment, these complications are only partially reversible. Exacerbation of prior autoimmune diseases is also seen. All of these lead to quality of life impairment and increased mortality. This review addresses the main comorbidities and long-term consequences of CS despite clinical and biochemical "cure".
authors.affiliation: Servicio de Endocrinología, Departamento de Medicina, Institut d'Investigació Biomèdica Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: aaulinasm@gmail.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Aulinas
authors.affiliation: Institut d'Investigació Biomèdica Sant Pau, Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBER-ER, Unidad 747), Instituto de Salud Carlos III, Barcelona, España.
authors.forename: Elena
authors.initials: E
authors.lastname: Valassi
authors.affiliation: Servicio de Endocrinología, Departamento de Medicina, Institut d'Investigació Biomèdica Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España; Institut d'Investigació Biomèdica Sant Pau, Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBER-ER, Unidad 747), Instituto de Salud Carlos III, Barcelona, España.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Webb
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000150:complications / Q000601:surgery; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000601:surgery; D000315:Adrenalectomy; D018246:Adrenocortical Adenoma / Q000150:complications / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D003480:Cushing Syndrome / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007016:Hypophysectomy; D047748:Pituitary ACTH Hypersecretion / Q000150:complications / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011379:Prognosis; D011788:Quality of Life
chemical_list: D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
keywords: Calidad de vida relacionada con la salud; Cardiovascular risk; Cushing disease; Cushing syndrome; Enfermedad de Cushing; Health-related quality of life; Mortalidad; Mortality; Osteoporosis; Remisión; Remission; Riesgo cardiovascular; Síndrome de Cushing