title: Comparative evaluation of aqueous and plasma concentration of topical moxifloxacin alone and with flurbiprofen in patients of cataract surgery.
abstract: OBJECTIVE
  To determine the aqueous and plasma concentrations of moxifloxacin administered topically alone and with flurbiprofen in patients undergoing cataract surgery.
  
  
  METHODS
  A total of 50 subjects scheduled for routine cataract surgery were randomly allocated to two groups (n = 25 each). Group-1 patients were treated with topical moxifloxacin alone: One drop 6 times/day for 3 days before surgery and one drop 4 times on the day of surgery: Group-2 patients were treated with topical moxifloxacin as in Group-1 and with topical flurbiprofen: One drop 4 times/day for 3 days before and on the day of surgery. The interval between two drugs was 30 min for last 3 days and 15 min on the day of surgery. Last dose was administered 1 h before aqueous humor and blood sampling for both the groups. The antibiotic concentration in aqueous humor and plasma were determined by using high performance liquid chromatography.
  
  
  RESULTS
  The mean concentration of moxifloxacin in aqueous humor was 1.71 ± 0.82 mg/ml in Group-1 and 2.39 ± 1.34 mg/ml in Group-2. Concentrations of moxifloxacin in aqueous humor were significantly higher in Group-2 than that of Group-1.
  
  
  CONCLUSIONS
  Flurbiprofen may increase the concentration of moxifloxacin in aqueous humor.
authors.affiliation: Department of Pharmacology, Malda Medical College, Malda, India.
authors.forename: Sujash
authors.initials: S
authors.lastname: Halder
authors.forename: Kanchan Kumar
authors.initials: KK
authors.lastname: Mondal
authors.forename: Supreeti
authors.initials: S
authors.lastname: Biswas
authors.forename: Tapan Kumar
authors.initials: TK
authors.lastname: Mandal
authors.forename: Bakul Kumar
authors.initials: BK
authors.lastname: Dutta
authors.forename: Mithilesh
authors.initials: M
authors.lastname: Haldar
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001082:Aqueous Humor / Q000378:metabolism*; D001372:Aza Compounds / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D002387:Cataract Extraction; D004359:Drug Therapy, Combination; D005260:Female; D024841:Fluoroquinolones; D005480:Flurbiprofen / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D011804:Quinolines / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D005480:Flurbiprofen; D000077266:Moxifloxacin
keywords: Aqueous humor; cataract surgery; flurbiprofen; moxifloxacin