title: Negative pressure wound therapy as an adjunct in healing of chronic wounds.
abstract: Negative pressure wound therapy (NPWT) has emerged as a cutting-edge technology and provides an alternative solution to the problem of wounds. This study was undertaken to assess the efficacy of this technique in the treatment of chronic wounds. A prospective clinical study was used to evaluate our experience in use of NPWT in the healing of pressure ulcers and chronic wounds over 2 years. The primary end point of the study group was the time taken for appearance of healthy granulation tissue and full reepithelialisation without drainage. All patients with sepsis were excluded from the study. The statistical analysis of the data was carried out. Of the 60 patients studied, 41 had associated comorbidities including diabetes mellitus. The commonest site of occurrence was the lower limb. Coverage in the form of a flap was required at presentation in 63·33% of patients. However, after initiation of NPWT, none of them required the procedure and they healed spontaneously either by secondary intention or by skin grafting. The time taken for appearance of healthy granulation tissue was 14·36 ± 4·24 days. Complete healing of wounds occurred by 33·1 ± 10·22 days. There was a statistically significant difference in the volume of the wounds before and after the intervention (P = 0·000). Complications resulting from NPWT were minimal. This technique is an excellent adjunct to surgical debridement.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Army Hospital (Research and Referral), New Delhi, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Langer
authors.affiliation: Department of Plastic and Reconstructive Surgery, Army Hospital (Research and Referral), New Delhi, India.
authors.forename: Prem S
authors.initials: PS
authors.lastname: Bhandari
authors.affiliation: Department of Surgery, Armed Forces Medical College, Pune, India.
authors.forename: Satyamoorthy
authors.initials: S
authors.lastname: Rajagopalan
authors.affiliation: Department of Plastic and Reconstructive Surgery, Army Hospital (Research and Referral), New Delhi, India.
authors.forename: Mrinal K
authors.initials: MK
authors.lastname: Mukherjee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D003668:Pressure Ulcer / Q000175:diagnosis* / Q000628:therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*; D055815:Young Adult
keywords: Chronic wounds; Negative pressure wound therapy; Vacuum sealing technique; Wound bed preparation; Wounds and injuries