title: Functional role of miR-34 family in human cancer.
abstract: Recently, microRNAs (miRNAs) including miR-34 family have been found to play a critical role in tumorigenesis through regulating the expression of its target genes, which are involved in many cellular processes such as cell proliferation, survival, apoptosis, migration, invasion and angiogenesis. Thus, this review described the role of miR-34 family and how its deregulation is involved in the development and progression of human malignances. Moreover, we described the potential role of miR-34 as a novel biomarker for tumor diagnosis. Furthermore, we summarized that miR-34 family could be up-regulated by natural compounds in human cancers. Therefore, targeting miR-34 family could be a novel strategy for achieving better treatment outcome of cancer patients in the future.
authors.affiliation: Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, 233004, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Jia
authors.initials: J
authors.lastname: Ma
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Jun
authors.initials: J
authors.lastname: Xia
authors.forename: Lucio
authors.initials: L
authors.lastname: Miele
authors.forename: Fazlul H
authors.initials: FH
authors.lastname: Sarkar
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Wang
mesh_terms: D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000032:analysis; D049109:Cell Proliferation; D002470:Cell Survival; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology* / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D005810:Multigene Family; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C522425:MIRN34 microRNA, human; D035683:MicroRNAs