title: Tomographic reconstruction of tissue properties and temperature increase for high-intensity focused ultrasound applications.
abstract: The acoustic and thermal properties as well as the temperature change within a tissue volume during high-intensity focused ultrasound ablation are critically important for treatment planning and monitoring. Described in this article is a tomographic reconstruction method used to determine the tissue properties and increase in temperature in a 3-D volume. On the basis of the iterative finite-element solution to the bioheat equation coupled with Tikhonov regularization techniques, our reconstruction algorithm solves the inverse problem of bioheat transfer and uses the time-dependent temperature measured on a tissue surface to obtain the acoustic absorption coefficient, thermal diffusivity and temperature increase within the subsurface volume. Numerical simulations were performed to validate the reconstruction algorithm. The method was initially conducted in ex vivo experiments in which time-dependent temperature on a tissue surface was measured using high-resolution, non-invasive infrared thermography.
authors.affiliation: Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611-6131, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Yin
authors.forename: Madhu Sudhan Reddy
authors.initials: MS
authors.lastname: Gudur
authors.forename: Yi-Sing
authors.initials: YS
authors.lastname: Hsiao
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Kumon
authors.forename: Cheri X
authors.initials: CX
authors.lastname: Deng
authors.forename: Huabei
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000042:Absorption; D000818:Animals; D001831:Body Temperature / Q000502:physiology* / Q000528:radiation effects*; D013504:Cardiovascular Surgical Procedures / Q000379:methods*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D006321:Heart / Q000502:physiology* / Q000528:radiation effects*; D019220:High-Energy Shock Waves; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D066298:In Vitro Techniques; D008954:Models, Biological; D011829:Radiation Dosage; D012542:Scattering, Radiation; D013552:Swine; D013817:Thermography / Q000379:methods
keywords: Bioheat equation; High-intensity focused ultrasound; Image reconstruction; Infrared thermography