title: The fate of untreated concomitant suprarenal aortic aneurysms after endovascular aneurysm repair of infrarenal aortic aneurysms.
abstract: OBJECTIVE
  Many patients treated with endovascular aortic repair (EVAR) have a concomitant suprarenal abdominal aortic aneurysm (sAAA). The natural history of these sAAAs and whether they require intervention after EVAR is unknown.
  
  
  METHODS
  We identified 470 patients from the M2S database (M2S Inc, West Lebanon, NH) as having an infrarenal AAA (iAAA) with a concomitant sAAA (diameter, 2.9-4.7 cm). The analysis included 217 patients with preoperative computed tomography angiography and follow-up imaging of ≥12 months. Patients who did not undergo EVAR (n = 65) served as a control. Patients with EVAR were subdivided into 90 with suprarenal fixation (SR) and 62 with infrarenal fixation (IR). Standard measurements from the M2S images were extracted, and growth rates were calculated for different abdominal aortic segments.
  
  
  RESULTS
  The average follow-up was 33.0 ± 18.8 months. The average sAAA initial size and growth rate were 34.6 ± 3.0 and 0.6 ± 1.1 mm/y for SR, 34.0 ± 3.3 and 0.6 ± 1.3 mm/y for IR, and 36.6 ± 3.4 and 1.2 ± 1.5 mm/y for controls (SR vs IR, P > .05; SR or IR vs control, P < .05). After EVAR, two of 152 (1.3%) sAAAs grew to ≥ 50 mm, which was not statistically different from four of 65 (6.2%) in the control group (P = .07). At 48 months, the Kaplan-Meier freedom from sAAA growth to ≥ 50 mm was 99.3% for patients undergoing EVAR and 95.2% for controls (P = .061). Patients with starting sAAAs sized ≥ 40 mm had a higher growth rate (1.4 ± 2.1 mm/y) and frequency of growth to ≥50 mm (14.3%) than patients with starting sAAAs sized <40 mm (0.7 ± 1.2 mm/y and 1.5%; P < .05).
  
  
  CONCLUSIONS
  Isolated treatment of iAAAs via EVAR with a concomitant sAAA is acceptable because endografts with or without SR do not affect sAAA growth rates. Routine EVAR follow-up is sufficient for sAAAs of <40 mm, and more intensive follow-up should be considered for sAAAs of 40 to 50 mm. For sAAAs approaching 50 mm, an endograft with IR should be considered in case sAAA repair is required in the future.
authors.affiliation: Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Perelman School of Medicine the University of Pennsylvania, Philadelphia, Pa.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Herdrich
authors.forename: Erin H
authors.initials: EH
authors.lastname: Murphy
authors.forename: Grace J
authors.initials: GJ
authors.lastname: Wang
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Jackson
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Fairman
authors.forename: Edward Y
authors.initials: EY
authors.lastname: Woo
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000601:surgery*; D001027:Aortography / Q000379:methods; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation; D006801:Humans; D053208:Kaplan-Meier Estimate; D009513:New Hampshire; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome