title: [Pediatric aids, 30 years later].
abstract: Thirty years after the first descriptions of AIDS in children in May 1983, the risk of viral transmission from mother to child has been reduced to almost zero and the disease in infected children has become an asymptomatic condition, stable in the long-term, thanks to antiretroviral drugs. Unbelievable though it may have seemed until the mid-1990s, children infected during the perinatal period are now growing up to be adults in a chronic, stable, asymptomatic medical condition with often satisfactory personal, family, and social lives. The French perinatal epidemiological cohort, which was set up in 1984 and has included more than 18,000 mother-child pairs to date, traces the steps in this extraordinary revolution in the prevention and treatment of HIV-1 infection in children.
authors.affiliation: Unité d'immunologie hématologie pédiatrique, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France. stephane.blanche@nck.aphp.fr
authors.forename: S
authors.initials: S
authors.lastname: Blanche
authors.forename: C
authors.initials: C
authors.lastname: Dollfus
authors.forename: A
authors.initials: A
authors.lastname: Faye
authors.forename: C
authors.initials: C
authors.lastname: Rouzioux
authors.forename: L
authors.initials: L
authors.lastname: Mandelbrot
authors.forename: R
authors.initials: R
authors.lastname: Tubiana
authors.forename: J
authors.initials: J
authors.lastname: Warszawski
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D002648:Child; D015331:Cohort Studies; D016021:Epidemiologic Studies; D005260:Female; D005602:France / Q000453:epidemiology; D020276:HIV Long-Term Survivors / Q000706:statistics & numerical data; D006304:Health Status; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors
chemical_list: D044966:Anti-Retroviral Agents