title: Naphtho-γ-pyrones from Endophyte Aspergillus niger occurring in the liverwort Heteroscyphus tener (Steph.) Schiffn.
abstract: Bioactivity-guided fractionation of the cytotoxic extract of Aspergillus niger, an endophytic fungus from the Chinese liverwort Heteroscyphus tener (Steph.) Schiffn., afforded five new naphtho-γ-pyrones, rubrofusarin-6-O-α-D-ribofuranoside (1), (R)-10-(3-succinimidyl)-TMC-256A1 (2), asperpyrone E (3), isoaurasperone A (4), and isoaurasperone F (5), as well as four known ones, dianhydroaurasperone C (6), aurasperone D (7), asperpyrone D (8), and asperpyrone A (9), together with a cytotoxic cyclic pentapeptide, malformin A1 (10). Their structures were determined by extensive spectroscopic analysis. The absolute configurations of dimeric naphtho-γ-pyrones 3-9 were also determined by analysis of their respective CD spectra.
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: Xie
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Zhou
authors.forename: Yong-Qing
authors.initials: YQ
authors.lastname: Liu
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Yuan
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D001234:Aspergillus niger / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D035926:Hepatophyta / Q000382:microbiology*; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D009281:Naphthalenes; D011753:Pyrones
keywords: Aspergillus niger; Cytotoxic activity; Fungi; Malformin A1; Naphtho-γ-pyrones