title: Aripiprazole, an atypical antipsychotic drug, improves maturation and complexity of neuroblast dendrites in the mouse dentate gyrus via increasing superoxide dismutases.
abstract: Apripiprazole (APZ) is well known as an atypical antipsychotic and antidepressant. In the present study, we investigated effects of APZ on cell proliferation and neuronal differentiation in the dentate gyrus (DG) of the adolescent mouse using BruU, Ki-67 and doublecortin (DCX) immunohistochemistry. BruU, Ki-67 and DCX-positive (+) cells were easily detected in the subgranular zone of the DG in the vehicle- and APZ-treated group. We found that in the 8 mg/kg APZ-treated group numbers of Ki-67(+), DCX(+) and BrdU(+)/DCX(+) cells were significantly increased compared with those in the vehicle-treated group. We also found that maturation and complexity of DCX(+) dendrites in the 8 mg/kg APZ-treated group was well improved compared with those in the vehicle-treated group. In addition, markedly decreased lipid peroxidation and increased superoxide dismutase 2 (SOD2) level were observed in the DG of the 8 mg/kg APZ-treated group. Our present findings indicate that APZ can enhance cell proliferation and neuroblast differentiation, particularly maturation and complexity of neuroblast dendrites, in the DG via decreasing lipid peroxidation and increasing SOD2 level.
authors.affiliation: Department of Physiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea.
authors.forename: Bai Hui
authors.initials: BH
authors.lastname: Chen
authors.forename: Bing Chun
authors.initials: BC
authors.lastname: Yan
authors.forename: Joon Ha
authors.initials: JH
authors.lastname: Park
authors.forename: Ji Hyeon
authors.initials: JH
authors.lastname: Ahn
authors.forename: Dae Hwan
authors.initials: DH
authors.lastname: Lee
authors.forename: In Hye
authors.initials: IH
authors.lastname: Kim
authors.forename: Jeong-Hwi
authors.initials: JH
authors.lastname: Cho
authors.forename: Jae-Chul
authors.initials: JC
authors.lastname: Lee
authors.forename: Sung Koo
authors.initials: SK
authors.lastname: Kim
authors.forename: Bonghee
authors.initials: B
authors.lastname: Lee
authors.forename: Jun Hwi
authors.initials: JH
authors.lastname: Cho
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Yun Lyul
authors.initials: YL
authors.lastname: Lee
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D000068180:Aripiprazole; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D000089662:Doublecortin Protein; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009474:Neurons / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D014150:Antipsychotic Agents; C000714847:Dcx protein, mouse; D000089662:Doublecortin Protein; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole; D013482:Superoxide Dismutase