title: Autoinflammatory disorders, pain, and neural regulation of inflammation.
abstract: Autoinflammatory disorders are disorders of the innate immune system that are distinct from autoimmune disorders. Dysregulation of the innate immune system, specifically an increase in interleukin-1 beta (IL-1β), gives rise to a spectrum of symptoms marked by inflammation and pain. Identification of causative gene mutations led to the discovery of the inflammasome. Many autoinflammatory disorders also have a strong pain component. The contribution of IL-1β to pain and neural involvement is underappreciated. This article provides an overview of the current autoinflammatory disorders and highlights the contribution IL-1β makes to pain in these disorders.
authors.affiliation: Galderma Laboratories, LP, 14501 North Freeway, Fort Worth, TX 76177, USA. michael.chen@galderma.com
authors.forename: Michael C
authors.initials: MC
authors.lastname: Chen
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Meckfessel
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology*; D056660:Hereditary Autoinflammatory Diseases / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology*; D053583:Interleukin-1beta / Q000276:immunology; D010146:Pain / Q000188:drug therapy / Q000276:immunology*
chemical_list: D058847:Inflammasomes; D053583:Interleukin-1beta
keywords: Autoinflammatory disorders; IL-1β; Inflammasome; Neural crosstalk; Neuromodulation; Pain