title: Investigation of pregnancy outcome and ovarian hyper stimulation syndrome prevention in agonist and antagonist gonadotropin-releasing hormone protocol.
abstract: BACKGROUND
  Given the controversies regarding the effectiveness of gonadotropin-releasing hormone (GnRH) antagonists in prevention of ovarian hyper stimulation syndrome stimulation, this study was designed to compare GnRH agonist protocol with GnRH antagonist protocol in patients who were candidate for assisted reproductive techniques (ARTs).
  
  
  METHODS
  This investigation was performed on 136 patients who were randomly allocated to two groups of GnRH agonist and GnRH antagonist. In the first group stimulation was performed by administration of Buserelin, and in the second group, it was performed by giving Cetrorelix. Then patients were compared regarding results of ovarian stimulation, pregnancy outcomes and rate of ovarian hyper stimulation syndrome (OHSS).
  
  
  RESULTS
  There were not significant differences between 2 groups regarding the ovarian stimulation, pregnancy outcomes and rate of OHSS (P value >0.05).
  
  
  CONCLUSIONS
  Administration of GnRH antagonists in ovarian stimulation will be a reasonable option to GnRH agonists in assessment reproduction treatment; however, further studies are suggested.
authors.affiliation: Associate professor of obstetrics and Gynecology, Departments of Obstetrics and Gynecology, school of medicine, Isfahan University of medical sciences,Isfahan, Iran.
authors.forename: Behnaz Khani
authors.initials: BK
authors.lastname: Rabati
authors.forename: Setare Nasiri
authors.initials: SN
authors.lastname: Zeidi
keywords: Assisted reproductive techniques; gonadotropin-releasing hormone agonist; gonadotropin-releasing hormone antagonist; ovarian hyper stimulation syndrome; ovarian stimulation; pregnancy rate