title: Treatment of superficial siderosis with iron chelation therapy.
abstract: Superficial siderosis is caused by recurrent haemorrhage in the subarachnoid space leading to haemosiderin deposition. It typically causes the triad of ataxia, deafness and myelopathy. We report a patient who developed superficial siderosis following neurosurgery for syringomyelia and who had an improvement in his hearing and mobility following treatment with a new iron chelation therapy that can penetrate the blood-brain barrier. It provides an intriguing insight into a therapy that could potentially modify the course of this rare neurodegenerative disorder. Further studies are required to assess the clinical efficacy of deferiprone in superficial siderosis.
authors.affiliation: Department of Clinical Neuroscience, The John Van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.
authors.forename: Gemma
authors.initials: G
authors.lastname: Cummins
authors.forename: Gemma
authors.initials: G
authors.lastname: Crundwell
authors.forename: David
authors.initials: D
authors.lastname: Baguley
authors.forename: Graham
authors.initials: G
authors.lastname: Lennox
mesh_terms: D000368:Aged; D015913:Chelation Therapy; D000077543:Deferiprone; D006801:Humans; D007501:Iron; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008297:Male; D011728:Pyridones / Q000627:therapeutic use*; D012806:Siderosis / Q000188:drug therapy*
chemical_list: D007502:Iron Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D007501:Iron