title: 3D modeling to characterize lamina cribrosa surface and pore geometries using in vivo images from normal and glaucomatous eyes.
abstract: En face adaptive optics scanning laser ophthalmoscope (AOSLO) images of the anterior lamina cribrosa surface (ALCS) represent a 2D projected view of a 3D laminar surface. Using spectral domain optical coherence tomography images acquired in living monkey eyes, a thin plate spline was used to model the ALCS in 3D. The 2D AOSLO images were registered and projected onto the 3D surface that was then tessellated into a triangular mesh to characterize differences in pore geometry between 2D and 3D images. Following 3D transformation of the anterior laminar surface in 11 normal eyes, mean pore area increased by 5.1 ± 2.0% with a minimal change in pore elongation (mean change = 0.0 ± 0.2%). These small changes were due to the relatively flat laminar surfaces inherent in normal eyes (mean radius of curvature = 3.0 ± 0.5 mm). The mean increase in pore area was larger following 3D transformation in 4 glaucomatous eyes (16.2 ± 6.0%) due to their more steeply curved laminar surfaces (mean radius of curvature = 1.3 ± 0.1 mm), while the change in pore elongation was comparable to that in normal eyes (-0.2 ± 2.0%). This 3D transformation and tessellation method can be used to better characterize and track 3D changes in laminar pore and surface geometries in glaucoma.
authors.affiliation: Department of Computer Science, University of Houston, Houston, TX 77004, USA.
authors.forename: Nripun
authors.initials: N
authors.lastname: Sredar
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Ivers
authors.forename: Hope M
authors.initials: HM
authors.lastname: Queener
authors.forename: George
authors.initials: G
authors.lastname: Zouridakis
authors.forename: Jason
authors.initials: J
authors.lastname: Porter
keywords: (000.3860) Mathematical methods in physics; (110.1080) Active or adaptive optics; (330.4460) Ophthalmic optics and devices