title: Calcium phosphate cement scaffolds with PLGA fibers.
abstract: The use of calcium phosphate-based biomaterials has revolutionized current orthopedics and dentistry in repairing damaged parts of the skeletal system. Among those biomaterials, the cement made of hydraulic grip calcium phosphate has attracted great interest due to its biocompatibility and hardening "in situ". However, these cements have low mechanical strength compared with the bones of the human body. In the present work, we have studied the attainment of calcium phosphate cement powders and their addition to poly (co-glycolide) (PLGA) fibers to increase mechanical properties of those cements. We have used a new method that obtains fibers by dripping different reagents. PLGA fibers were frozen after lyophilized. With this new method, which was patented, it was possible to obtain fibers and reinforcing matrix which furthered the increase of mechanical properties, thus allowing the attainment of more resistant materials. The obtained materials were used in the construction of composites and scaffolds for tissue growth, keeping a higher mechanical integrity.
authors.affiliation: Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Materiais (PPGE3M), Laboratório de Biomateriais (LABIOMAT), Brazil. levasconcellos@gmail.com
authors.forename: Letícia Araújo
authors.initials: LA
authors.lastname: Vasconcellos
authors.forename: Luís Alberto
authors.initials: LA
authors.lastname: dos Santos
mesh_terms: D000042:Absorption; D000818:Animals; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D019245:Compressive Strength; D055119:Elastic Modulus; D004553:Electric Conductivity; D017097:Electric Impedance; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013997:Time Factors; D054457:Tissue Scaffolds / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D012997:Solvents; C485828:alpha-tricalcium phosphate; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: Alpha-tricalcium phosphate (α-TCP); Biocompatibility; Fibers; Lyophilization; PLGA; Scaffolds