title: Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis.
abstract: A 56-year-old Japanese man developed a cerebral hemorrhage and was diagnosed with plasma cell-type multicentric Castleman's disease (MCD) based on the findings of an inguinal lymph node biopsy in addition to clinical findings, including hypergammaglobulinemia, anemia and elevation of the levels of CRP and serum IL-6. Although a renal biopsy showed nephrosclerosis, the levels of serum lipids and apolipoprotein were low. Following the initiation of treatment with anti-interleukin-6 receptor antibodies, the hypergammaglobulinemia, anemia, CRP level and serum lipid profile improved. However, inflammation due to overproduction of IL-6 persisted, and atherosclerotic vascular events occurred as critical complications, even though the serum levels of lipids were very low.
authors.affiliation: Nephrology Center, Toranomon Hospital, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Imafuku
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suwabe
authors.forename: Eiko
authors.initials: E
authors.lastname: Hasegawa
authors.forename: Koki
authors.initials: K
authors.lastname: Mise
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sumida
authors.forename: Rikako
authors.initials: R
authors.lastname: Hiramatsu
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamanouchi
authors.forename: Noriko
authors.initials: N
authors.lastname: Hayami
authors.forename: Junichi
authors.initials: J
authors.lastname: Hoshino
authors.forename: Naoki
authors.initials: N
authors.lastname: Sawa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Oohashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
authors.forename: Minoru
authors.initials: M
authors.lastname: Okubo
authors.forename: Kenmei
authors.initials: K
authors.lastname: Takaichi
authors.forename: Tatsuhide
authors.initials: T
authors.lastname: Oga
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ubara
mesh_terms: D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis*; D050171:Dyslipidemias / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009400:Nephrosclerosis / Q000150:complications / Q000175:diagnosis*