title: Effects of human bone marrow mesenchymal stem cells on burn injury healing in a mouse model.
abstract: OBJECTIVE
  To investigate the feasibility and safety of human bone marrow mesenchymal stem cells (BM-MSCs) transplantation on the improvement of burn wound healing.
  
  
  METHODS
  Human BM-MSCs were injected into the skin of the mouse models, and the new blood vessels growth, the engraftment of BM-MSCs and the speed of healing were observed. Moreover the body weight and activity were tested after BM-MSCs transplantation.
  
  
  RESULTS
  We found that wound surface healing was significantly accelerated when BM-MSCs were applied to the wound surface in mice. Moreover, both the number and density of new blood vessels were increased in the BM-MSC-treated group. The engraftment of BM-MSCs was also investigated using GFP-labeled cells and no GFP-positive cells were observed in tissues other than the location of BM-MSC injection. We also found that both body weight and activity were quickly restored in BM-MSC-treated mice, and no tumor growth was found.
  
  
  CONCLUSIONS
  The present results suggest that BM-MSC transplantation can effectively improve wound healing in a mouse model of burn injuries. Use of BM-MSCs might therefore facilitate development and improvement of burn injury treatments in future.
authors.affiliation: Department of Burns, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong, P R China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xue
authors.forename: Ying-Bin
authors.initials: YB
authors.lastname: Xu
authors.forename: Ju-Lin
authors.initials: JL
authors.lastname: Xie
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Tang
authors.forename: Bin
authors.initials: B
authors.lastname: Shu
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Shao-Hai
authors.initials: SH
authors.lastname: Qi
authors.forename: Xu-Sheng
authors.initials: XS
authors.lastname: Liu
mesh_terms: D000818:Animals; D002056:Burns / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005240:Feasibility Studies; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D018919:Neovascularization, Physiologic; D012867:Skin / Q000098:blood supply / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D014162:Transfection; D015430:Weight Gain; D014945:Wound Healing
chemical_list: D049452:Green Fluorescent Proteins
keywords: Bone marrow mesenchymal stem cells; burn injury; mouse model; wound healing