title: The Severe Respiratory Insufficiency Questionnaire scored best in the assessment of health-related quality of life in chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  There are limited data on health-related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure during an admission requiring ventilatory support. The aim was to assess and compare the reliability and validity of the Clinical COPD Questionnaire (CCQ), Chronic Respiratory Questionnaire (CRQ), Maugeri Respiratory Failure-28 (MRF-28) Questionnaire, and Severe Respiratory Insufficiency (SRI) Questionnaire in patients with very severe COPD.
  
  
  METHODS
  One hundred eighty hospitalized patients filled out the CCQ, CRQ, MRF-28, SRI, Groningen Activity Restriction Scale (GARS), Hospital Anxiety and Depression Scale (HADS), and the Medical Research Council Dyspnea Scale (MRC). Reliability was examined by assessing distribution of total scores, floor and ceiling effects, and internal consistency (using Cronbach α coefficient). Construct validity between questionnaires and also the other measurements were tested with Spearman ρ.
  
  
  RESULTS
  All four questionnaires were feasible in this setting and had reasonable characteristics for distribution of total scores, floor and ceiling effects, internal consistency, and construct validity. On balance, the SRI scored best. Additionally, the SRI had a remarkable high explained variance by HADS, GARS, and MRC (73%).
  
  
  CONCLUSIONS
  The SRI performed slightly better than the CCQ, CRQ, and MRF-28, which renders it the preferred questionnaire for scoring HRQL in patients with very severe COPD.
authors.affiliation: Department of Pulmonology/Center for Home Mechanical Ventilation, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands. f.m.struik@umcg.nl
authors.forename: Fransien M
authors.initials: FM
authors.lastname: Struik
authors.forename: Huib A M
authors.initials: HA
authors.lastname: Kerstjens
authors.forename: Gerrie
authors.initials: G
authors.lastname: Bladder
authors.forename: Roy
authors.initials: R
authors.lastname: Sprooten
authors.forename: Marianne
authors.initials: M
authors.lastname: Zijnen
authors.forename: Jerryll
authors.initials: J
authors.lastname: Asin
authors.forename: Thys
authors.initials: T
authors.lastname: van der Molen
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Wijkstra
mesh_terms: D000368:Aged; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D011788:Quality of Life; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
keywords: COPD; Chronic respiratory failure; Health domain; Health status; Noninvasive positive pressure ventilation; Questionnaire