title: Paramagnetic solid lipid nanoparticles as a novel platform for the development of molecular MRI probes.
abstract: Highly efficient magnetic resonance imaging (MRI) probes have been prepared by loading Gd(III) complexes on the surface of solid lipid nanoparticles (pSLNs). Applicability as molecular imaging probes is demonstrated by an in vitro model study with targeted pSLNs.
authors.affiliation: Dipartimento di Scienze e Innovazione Tecnologica, Università degli Studi del Piemonte Orientale Amedeo Avogadro, Viale T. Michel 11, 15121 Alessandria, Italy.
authors.forename: Gabriele A
authors.initials: GA
authors.lastname: Rolla
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Tei
authors.forename: Claudia
authors.initials: C
authors.lastname: Cabella
authors.forename: Simona
authors.initials: S
authors.lastname: Ghiani
authors.forename: Chiara
authors.initials: C
authors.lastname: Brioschi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Maiocchi
mesh_terms: D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D018613:Microscopy, Confocal; D015335:Molecular Probes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D008055:Lipids; D015335:Molecular Probes; D005682:Gadolinium
keywords: contrast agents; lanthanides; lipidic nanoparticles; magnetic resonance imaging; relaxivity