title: Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii.
abstract: A macrocylic dodecapeptide, cycloforskamide, was isolated from the sea slug Pleurobranchus forskalii, collected off Ishigaki Island, Japan. Its planar structure was deduced by extensive NMR analyses and was further confirmed by MS/MS fragmentation analyses. Finally, the absolute configuration was determined by total hydrolysis and chiral-phase gas chromatographic analysis. This novel dodecapeptide contains three d-amino acids and three thiazoline heterocycles and exhibits cytotoxicity against murine leukemia P388 cells, with an IC50 of 5.8 μM.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033, Japan.
authors.forename: Karen Co
authors.initials: KC
authors.lastname: Tan
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Wakimoto
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takada
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: Nahoko
authors.initials: N
authors.lastname: Uchiyama
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda
authors.forename: Ikuro
authors.initials: I
authors.lastname: Abe
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D049851:Gastropoda / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007564:Japan; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D009792:Oceans and Seas; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C584071:cycloforskamide