title: Channel gating pore: a new therapeutic target.
abstract: Each subunit of voltage-gated cation channels comprises a voltage-sensing domain and a pore region. In a paper recently published in Cell Research, Li et al. showed that the gating charge pathway of the voltage sensor of the KCNQ2 K+ channel can accommodate small opener molecules and offer a new target to treat hyperexcitability disorders.
authors.affiliation: Department of Physiology & Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Polina
authors.initials: P
authors.lastname: Kornilov
authors.forename: Asher
authors.initials: A
authors.lastname: Peretz
authors.forename: Bernard
authors.initials: B
authors.lastname: Attali
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism*; D001549:Benzamides / Q000494:pharmacology*; D004827:Epilepsy / Q000378:metabolism*; D051658:KCNQ2 Potassium Channel / Q000378:metabolism*; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D051637:Shaker Superfamily of Potassium Channels / Q000378:metabolism*
chemical_list: D000927:Anticonvulsants; D001549:Benzamides; D051658:KCNQ2 Potassium Channel; C587501:N-(6-chloropyridin-3-yl)-4-fluorobenzamide; D011725:Pyridines; D051637:Shaker Superfamily of Potassium Channels