title: New steroids and sesquiterpene from Turraea pubescens.
abstract: Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C₂₂ steroids isolated from the Meliaceae family for the first time. Their structures were elucidated by extensive NMR and MS analyses. Compound 1 exhibited inhibitory activity against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cells with an IC₅₀ value of 11.5 μM.
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Chun-Mao
authors.initials: CM
authors.lastname: Yuan
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Cao
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D002460:Cell Line; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018547:Plant Stems; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D010840:Phytosterols; D010936:Plant Extracts; D012717:Sesquiterpenes; C000588610:turranin A; D009569:Nitric Oxide
keywords: Anti-inflammatory; Meliaceae; Sesquiterpene; Steroids; Turraea pubescens