title: Lobular intraepithelial neoplasia arising within breast fibroadenoma.
abstract: BACKGROUND
  Fibroadenomas are the second most common breast pathology occurring in young women under the age of 35 years old. Fibroadenomas can be classified as simple or complex according to histological features. Complex fibroadenomas differ from simple fibroadenomas because of the presence of cysts (3 mm), sclerosing adenosis, epithelial calcifications, or papillary apocrine changes. Most fibroadenomas are clinically identifiable. In 25% of cases, fibroadenomas are non-palpable and are diagnosed with mammography and ultrasound. Differential diagnosis with well differentiated breast cancer is often necessary, particularly with medullary or mucinous tumors. Calcification findings within fibroadenomas by mammogram have to be investigated. The age of a lump is usually reflected by calcifications. Microcalcification can hide foci of carcinoma in situ when they are small, branching type, and heterogeneous. However, many morphological possibilities may not be reliable for deciding whether a certain calcification is the product of a malignant or a benign process. From a radiological point of view, fibroadenomas containing foci of carcinoma in situ can be indistinguishable from benign lesions, even if the incidence of carcinoma within fibroadenomas is estimated as 0.1-0.3%, and it could be a long-term risk factor for invasive breast cancer.
  
  
  METHODS
  A 44-year-old woman presented with a 1.5-cm palpable, smooth, mobile lump in the lower-inner quadrant of her right breast. Standard mediolateral oblique and craniocaudal mammograms showed a cluster of eccentric popcorn-like calcifications within the fibroadenoma. After lumpectomy, a definitive histological examination confirmed the intra-operative diagnosis of a benign mass. However, lobular intraepithelial neoplasia foci were found, surrounded by atypical lobular hyperplasia.
  
  
  CONCLUSIONS
  The possibility of an old benign breast lump might be supported by fine needle aspiration biopsy or core biopsy before initiating follow-up. According to our experience, when patients are older than 40 years and have a familial history of breast cancer, we prefer to carry out lumpectomy with follow up to avoid the risk of underestimation in situ foci within the lump.
authors.affiliation: University Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Naples, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Limite
authors.forename: Emanuela
authors.initials: E
authors.lastname: Esposito
authors.forename: Viviana
authors.initials: V
authors.lastname: Sollazzo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ciancia
authors.forename: Cesare
authors.initials: C
authors.lastname: Formisano
authors.forename: Rosa
authors.initials: R
authors.lastname: Di Micco
authors.forename: Dario
authors.initials: D
authors.lastname: De Rosa
authors.forename: Pietro
authors.initials: P
authors.lastname: Forestieri
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D018226:Fibroadenoma / Q000473:pathology*; D006801:Humans