title: Effect of eicosapentaenoic acid agent on aggravated hypertriglyceridemia during pregnancy.
abstract: Aggravated hypertriglyceridemia with a serum triglyceride of more than 1000 mg/dL is a risk of acute pancreatitis during pregnancy. However, there have been few reports on the administration of an eicosapentaenoic acid (EPA) agent for aggravated hypertriglyceridemia during pregnancy. A 29-year-old multiparous Japanese woman was transferred to our hospital at 29 + 0 weeks of gestation due to hypertriglyceridemia of 898 mg/dL. Because diet control was not enough, we decided to use an EPA agent, resulting in a reduction in triglyceride levels to 550 mg/dL. A male infant, weighing 2667 g, was born at 37 + 2 weeks transabdominally, and was complicated with respiratory distress syndrome. The final diagnosis was type III hyperlipoproteinemia with the apolipoprotein E3/2 phenotype and a broad β-migrating lipoprotein on polyacrylamide gel electrophoresis of serum lipoproteins. In conclusion, an EPA agent may be a possible therapeutic approach for aggravated hypertriglyceridemia during pregnancy, although it may increase a risk of respiratory distress syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, Nakatsu Municipal Hospital, Oita, Japan.
authors.forename: Shimpei
authors.initials: S
authors.lastname: Sato
authors.forename: Akihide
authors.initials: A
authors.lastname: Ohkuchi
authors.forename: Mikihiko
authors.initials: M
authors.lastname: Kawano
authors.forename: Naoko
authors.initials: N
authors.lastname: Iwanaga
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Furukawa
authors.forename: Harunobu
authors.initials: H
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D015118:Eicosapentaenoic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*
chemical_list: D015118:Eicosapentaenoic Acid
keywords: apolipoprotein E3/2; eicosapentaenoic acid; hypertriglyceridemia; pregnancy; type III hyperlipoproteinemia