title: Kaempferol inhibits cancer cell growth by antagonizing estrogen-related receptor α and γ activities.
abstract: Kaempferol is a dietary flavonoid that can function as a selective estrogen receptor modulator (SERM). Estrogen-related receptors alpha and gamma (ERRα and ERRγ) are orphan nuclear receptors that play important roles in mitochondrial biogenesis and cancer development. We have shown that kaempferol can functionally antagonize the activities of ERRs based on both response element reporter systems and target gene analysis. Kaempferol modulation of mitochondrial function and suppression cancer cell growth has been confirmed. These findings suggest that kaempferol may exert their anti-cancer activities through antagonizing ERRs activities.
authors.affiliation: First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
authors.forename: Haibin
authors.initials: H
authors.lastname: Wang
authors.forename: Minghui
authors.initials: M
authors.lastname: Gao
authors.forename: Junjian
authors.initials: J
authors.lastname: Wang
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D017930:Genes, Reporter; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D044949:Kaempferols / Q000494:pharmacology*; D063269:Mitochondrial Turnover / Q000187:drug effects / Q000235:genetics; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*; D000097983:ERRalpha Estrogen-Related Receptor
chemical_list: D044949:Kaempferols; D017382:Reactive Oxygen Species; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor; C490917:ESRRG protein, human; C006552:kaempferol
keywords: cancer cell; estrogen related receptor; kaempferol; mitochondrial function