title: Elevated level of membrane microparticles in the disease of steroid-induced vascular osteonecrosis.
abstract: As a common disease, osteonecrosis attracts more and more attention. In this paper, we investigated the relationship between the alterations of endothelial-derived and platelet-derived microparticles and the changes of coagulation and inflammation in the steroid-induced avascular osteonecrosis of femoral head using the rabbit model. We also explored the possible mechanism of the membrane particles associated with the development of the rabbit femoral head ischemic necrosis. With a 28-day continuous observation, the level of membrane microparticles was significantly heightened after methylprednisolone treatment. The coagulating and inflammatory factors also tended to increase. The data demonstrated that the levels of membrane microparticles had significantly individual differences, which meant the increased levels of membrane microparticles may be related to hypercoagulability, thrombosis, and inflammation in microcirculation and played an important role in steroid-induced osteonecrosis. It will be very useful and helpful to guide clinical trials.
authors.affiliation: Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Wu
authors.forename: Chunliang
authors.initials: C
authors.lastname: Ji
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Guixing
authors.initials: G
authors.lastname: Qiu
authors.forename: Cunji
authors.initials: C
authors.lastname: Gao
authors.forename: Xisheng
authors.initials: X
authors.lastname: Weng
mesh_terms: D000818:Animals; D055252:Cell-Derived Microparticles / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced*; D005434:Flow Cytometry; D007273:Injections, Intramuscular; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects* / Q000494:pharmacology*; D010020:Osteonecrosis / Q000139:chemically induced* / Q000473:pathology*; D011817:Rabbits
chemical_list: D008775:Methylprednisolone