title: Pulmonary tumor thrombotic microangiopathy from metastatic epithelioid angiosarcoma.
abstract: The lung is most common site for metastatic disease via hematogenous route. Tumor emboli of the vessels of the lung induces fibrocellular and fibromuscular intimal proliferation. These histopathological changes may cause pulmonary tumor trombotic microangiopaty. Few cases are diagnosed antemortem. We report a 60 year old woman with by metastatic epithelioid angiosarcoma involving the lung. Tumor cells were positive for VEGF and topoisomerase II. VEGF may be involved in the pathogenesis pulmonary tumor trombotic microangioapy and topoisomerase II positivity showed sensitivity against catalytic topoisomerase II inhibitors.
authors.affiliation: Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, Department of Pathology, Ankara, Turkey;
authors.forename: Funda
authors.initials: F
authors.lastname: Demirag
authors.forename: Ebru
authors.initials: E
authors.lastname: Cakir
authors.forename: Ulku
authors.initials: U
authors.lastname: Yazici
authors.forename: Irfan
authors.initials: I
authors.lastname: Tastepe
keywords: Angiosarcoma; Pulmonary tumor thrombotic microangiopathy; Topoisomerase II; Vascular endothelial growth factor