title: Two difficulty diagnosis cases of severe veno-occlusive disease.
abstract: BACKGROUND
  The occurrence of Hepatic veno-occlusive disease (VOD) is rale liver disease. However, severe VOD is often lethal and one of the most common causes of death following stem cell transplantation (SCT).
  
  
  METHODS
  Case 1 was a 30-year-old woman who was diagnosed as Budd-Chiari syndrome with liver failure. She was admitted to our department to undergo liver transplantation. Four days after admission, she underwent liver transplantation. Her liver explant showed VOD. Case 2 was a 74-year-old woman who was admitted to a community hospital for further examination. Her condition continued to deteriorate with liver failure, and she died 39 days after admission. Liver autopsy also showed VOD. Either of the patients had difficulty in diagnose as VOD. Neither of the patients had a history of SCT.
  
  
  CONCLUSIONS
  VOD should be considered as a cause of acute hepatic failure, even if the patient has no history of SCT.
authors.affiliation: Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Miyaaki
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Naota
authors.initials: N
authors.lastname: Taura
authors.forename: Takuya
authors.initials: T
authors.lastname: Honda
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Shibata
authors.forename: Taro
authors.initials: T
authors.lastname: Akashi
authors.forename: Shinobu
authors.initials: S
authors.lastname: Yamamichi
authors.forename: Shotaro
authors.initials: S
authors.lastname: Turuta
authors.forename: Akihiko
authors.initials: A
authors.lastname: Soyama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hidaka
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Takatsuki
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Okudaira
authors.forename: Susumu
authors.initials: S
authors.lastname: Eguchi
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakashima
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
keywords: liver failure; stem cell transplantation; veno-occlusive disease