title: Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits.
abstract: Various synthetic bone substitutes have been developed to reconstruct the bony defects that clinicians often encounter during surgical procedures. Among various synthetic bone substitutes, calcium phosphate (Ca-P) ceramics have been investigated because their composition and structure are similar to those of human bone. We evaluated the bone healing and biodegradation patterns of three types of Ca-P ceramic particle with various hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) weight ratio: pure β-TCP, biphasic Ca-P (BCP) with a HA/β-TCP weight ratio of 60/40 (BCP 60/40), and BCP with an HA/β-TCP weight ratio of 20/80 (BCP 20/80). Four 8-mm-diameter defects were created in ten rabbits. Three of the defects in each rabbit were separately and randomly filled with one of the three experimental Ca-P ceramic particles, and the fourth was filled with blood clots (control). The specimens were harvested at 2 and 8 weeks post-surgery. The histologic and histometric findings revealed that the augmented space and new bone formation were significantly better for all three Ca-P ceramics than for the control group at both 2 and 8 weeks (p < 0.05). Compared to the pure β-TCP, the two BCP groups were found to provide a larger amount of newly formed bone and bone density at the 2- and 8-week post-operative periods (p < 0.05). Throughout the observation period, BCP 60/40 and BCP 20/80 exhibited a similar bone healing and biodegradation patterns with regard to both individual particles and the total augmented area in vivo.
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, 120-752, Republic of Korea.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Yang
authors.forename: Otgonbayar
authors.initials: O
authors.lastname: Unursaikhan
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Ui-Won
authors.initials: UW
authors.lastname: Jung
authors.forename: Chang-Sung
authors.initials: CS
authors.lastname: Kim
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry* / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D011817:Rabbits; D012886:Skull / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C018392:tricalcium phosphate
keywords: beta tricalcium phosphate; biodegradation; bone regeneration; hydroxyapatite; synthetic bone graft