title: Comparison of genomic and amino acid sequences of eight Japanese encephalitis virus isolates from bats.
abstract: We compared nucleotide and deduced amino acid sequences of eight Japanese encephalitis virus (JEV) isolates derived from bats in China. We also compared the bat JEV isolates with other JEV isolates available from GenBank to determine their genetic similarity. We found a high genetic homogeneity among the bat JEVs isolated in different geographical areas from various bat species at different time periods. All eight bat JEV isolates belonged to genotype III. The mean evolutionary rate of bat JEV isolates was lower than those of isolates of other origin, but this difference was not statistically significant. Based on these results, we presume that the bat JEV isolates might be evolutionarily conserved. The eight bat JEV isolates were phylogenetically similar to mosquito BN19 and human Liyujie isolates of JEV. These results indicate that bats might be involved in natural cycle of JEV.
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, 510515, Guangdong, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Liu
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Chen
authors.forename: Yixiong
authors.initials: Y
authors.lastname: Chen
authors.forename: Qionghua
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yuxue
authors.initials: Y
authors.lastname: Liao
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Xuemei
authors.initials: X
authors.lastname: Ke
authors.forename: Lizhen
authors.initials: L
authors.lastname: Ma
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Xiao
authors.forename: Yi
authors.initials: Y
authors.lastname: Wu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Junhua
authors.initials: J
authors.lastname: Zhou
authors.forename: Xueyan
authors.initials: X
authors.lastname: Zheng
authors.forename: Jiandong
authors.initials: J
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D002681:China; D002685:Chiroptera / Q000821:virology*; D016000:Cluster Analysis; D004664:Encephalitis Virus, Japanese / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D058974:Phylogeography; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013997:Time Factors; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins