title: Increased choroidal thickness in patients with Sturge-Weber syndrome.
abstract: OBJECTIVE
  With the recent development of enhanced depth imaging spectral-domain optical coherence tomography (SD-OCT), it is now possible to measure choroidal thickness in patients with Sturge-Weber syndrome and detect abnormalities that are not visible as part of the fundus examination.
  
  
  METHODS
  We were successful in imaging at least 1 eye in 12 individuals with Sturge-Weber syndrome using enhanced depth imaging SD-OCT. Eyes were defined as affected if they manifested at least one of the following: darkened choroid, glaucomatous optic nerve damage, or conjunctival hyperemia. None of the participants had a clinically visible choroidal hemangioma. The affected eyes had over twice the choroidal thickness of the unaffected eyes (mean [SD], 697 [337] μm vs 331 [94] μm; P = .004, determined by use of an unpaired t test). For the 6 unilaterally affected participants who had both eyes imaged, the choroidal thickness was greater in the affected eyes than in the unaffected eyes of 5 participants (mean [SD], 672 [311] μm vs 329 [88] μm; P = .01, determined by use of a paired t test).
  
  
  CONCLUSIONS
  The advent of enhanced depth imaging SD-OCT has allowed us to quantify choroidal thickness in the posterior pole, even in eyes with a markedly thickened choroid, such as those found in individuals with Sturge-Weber syndrome. Spectral-domain OCT has a much higher resolution (5-10 μm) than B-scan ultrasonography (150 μm) and can be used to distinguish between the retina and the choroid. Furthermore, enhanced depth imaging SD-OCT can detect choroidal thickness in eyes without clinically apparent choroidal abnormalities.
authors.affiliation: Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Karun S
authors.initials: KS
authors.lastname: Arora
authors.forename: Harry A
authors.initials: HA
authors.lastname: Quigley
authors.forename: Anne M
authors.initials: AM
authors.lastname: Comi
authors.forename: Rhonda B
authors.initials: RB
authors.lastname: Miller
authors.forename: Henry D
authors.initials: HD
authors.lastname: Jampel
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002829:Choroid / Q000473:pathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D013341:Sturge-Weber Syndrome / Q000175:diagnosis*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity