title: Genetic and non-genetic factors affecting the visual outcome of ocular Behcet's disease.
abstract: OBJECTIVE
  To examine the prognostic factors for visual outcome in Korean BD patients with uveitis.
  
  
  METHODS
  Seventy-seven Korean BD patients with uveitis were enrolled. HLA-B and HLA-A genotypes were determined by PCR-based method. Visual acuity was measured by Snellen chart. Vision loss was graded into visual impairment (VI) defined as VA<20/40 for more than 6 months, loss of useful vision (LUV) as VA < 20/200, and near total blindness (NTB) as VA of light perception or worse.
  
  
  RESULTS
  VI was associated with a longer duration of uveitis, posterior uveitis, and cataract, LUV with male gender, a longer duration of uveitis, posterior uveitis, and cataract, and NTB with a longer duration of uveitis, cataract, and glaucoma. HLA-B*51 and HLA-A*26:01 did not show any association with VI, LUV, or NTB. However, HLA-B*51 carriers had earlier onset of uveitis and HLA-A*26:01 was strongly associated with posterior uveitis. In patients with posterior uveitis, VI was associated with a longer duration of uveitis and cataract, LUV with a longer duration, and NTB with HLA-B*51.
  
  
  CONCLUSIONS
  Longer duration of uveitis, posterior uveitis, male gender, cataract, and glaucoma were found to be associated with poor visual outcome in BD-related uveitis. HLA-B*51 was associated with NTB in patients with posterior uveitis. HLA-A*26:01 showed no association with VI, LUV, or NTB, however, was strongly associated with posterior uveitis.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Kang
authors.forename: Jun Won
authors.initials: JW
authors.lastname: Park
authors.forename: Chaerin
authors.initials: C
authors.lastname: Park
authors.forename: Hyeong Gon
authors.initials: HG
authors.lastname: Yu
authors.forename: Eun Bong
authors.initials: EB
authors.lastname: Lee
authors.forename: Myoung Hee
authors.initials: MH
authors.lastname: Park
authors.forename: Yeong Wook
authors.initials: YW
authors.lastname: Song
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D059949:HLA-B51 Antigen / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011379:Prognosis; D012307:Risk Factors; D014605:Uveitis / Q000209:etiology / Q000235:genetics; D014792:Visual Acuity
chemical_list: D015234:HLA-A Antigens; C039683:HLA-A*26 antigen; D015235:HLA-B Antigens; D059949:HLA-B51 Antigen
keywords: BD; Behcet’s disease; CF; CI; HM; LUV; NTB; OR; PCR; S-Ag; SD; VA; VI; confidence intervals; counting fingers; hand motion; loss of useful vision; near total blindness; odds ratio; polymerase chain reaction; soluble antigen; standard deviation; visual acuity; visual impairment