title: Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia.
abstract: Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked. In epithelia, pre-neoplastic transformation stages are often distinguished by the appearance of phenotypic features of another differentiated tissue, termed metaplasia. In haemato/lymphopoietic malignancies, cell lineage ambiguity is increasingly recorded. Both, metaplasia and biphenotypic leukaemia/lymphoma represent examples of dysregulated cell differentiation that reflect a history of trans-differentiation and/or epigenetic reprogramming. Here we compare the similarity between molecular events of experimental cell trans-differentiation as an emerging therapeutic concept, with lineage confusion, as in metaplasia and dysplasia forecasting tumour development.
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany. goncalo.regalo@mdc-berlin.de
authors.forename: Gonçalo
authors.initials: G
authors.lastname: Regalo
authors.forename: Achim
authors.initials: A
authors.lastname: Leutz
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic; D044127:Epigenesis, Genetic; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism; D008679:Metaplasia / Q000378:metabolism*; D051379:Mice; D010641:Phenotype; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors
keywords: carcinogenesis; haematopoiesis; metaplasia; trans-differentiation; transcription factor