title: Chameleon-like self-assembling peptides for adaptable biorecognition nanohybrids.
abstract: We present here the development of adaptable hybrid materials in which self-assembling peptides can sense the diameter/curvature of carbon nanotubes and then adjust their overall structures from disordered states to α-helices, and vice versa. The peptides within the hybrid materials show exceptionally high thermal-induced conformational stability and molecular recognition capability for target RNA. This study shows that the context-dependent protein-folding effects can be realized in artificial nanosystems and provides a proof of principle that nanohybrid materials decorated with structured and adjustable peptide units can be fabricated using our strategy, from which smart and responsive organic/inorganic hybrid materials capable of sensing and controlling diverse biological molecular recognition events can be developed.
authors.affiliation: Translational Research Center for Protein Function Control and Department of Materials Science & Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea.
authors.forename: Woo-jin
authors.initials: WJ
authors.lastname: Jeong
authors.forename: Sung-ju
authors.initials: SJ
authors.lastname: Choi
authors.forename: Jun Shik
authors.initials: JS
authors.lastname: Choi
authors.forename: Yong-beom
authors.initials: YB
authors.lastname: Lim
mesh_terms: D000327:Adsorption; D000595:Amino Acid Sequence; D003102:Colloids / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D017510:Protein Folding; D017433:Protein Structure, Secondary; D012313:RNA / Q000737:chemistry; D013696:Temperature; D054321:rev Gene Products, Human Immunodeficiency Virus / Q000737:chemistry
chemical_list: D003102:Colloids; D037742:Nanotubes, Carbon; D010455:Peptides; D054321:rev Gene Products, Human Immunodeficiency Virus; C514860:rev protein, Human Immunodeficiency Virus-1; D012313:RNA