title: Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.
abstract: OBJECTIVE
  Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA.
  
  
  METHODS
  A cohort of 4286 RA patients from across Europe and 5642 population matched controls were genotyped for 25 SNPs, then combined in a meta-analysis with previously published data.
  
  
  RESULTS
  Significant evidence of association was detected for nine SNPs within the European samples. When meta-analysed with previously published data, 21 SNPs were associated with RA susceptibility. Although SNPs in the PTPN2 gene were previously reported to be associated with RA in both Japanese and European populations, we show genome-wide evidence for a different SNP within this gene associated with RA susceptibility in an independent European population (rs7234029, P = 4.4×10(-9)).
  
  
  CONCLUSIONS
  This study provides further genome-wide evidence for the association of the PTPN2 locus (encoding the T cell protein tyrosine phosphastase) with Caucasian RA susceptibility. This finding adds to the growing evidence for PTPN2 being a pan-autoimmune susceptibility gene.
authors.affiliation: Arthritis Research UK Epidemiology Unit, Central Manchester Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom. joanna.cobb@manchester.ac.uk
authors.forename: Joanna E
authors.initials: JE
authors.lastname: Cobb
authors.forename: Darren
authors.initials: D
authors.lastname: Plant
authors.forename: Edward
authors.initials: E
authors.lastname: Flynn
authors.forename: Meriem
authors.initials: M
authors.lastname: Tadjeddine
authors.forename: Philippe
authors.initials: P
authors.lastname: Dieudé
authors.forename: François
authors.initials: F
authors.lastname: Cornélis
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Ärlestig
authors.forename: Solbritt Rantapää
authors.initials: SR
authors.lastname: Dahlqvist
authors.forename: George
authors.initials: G
authors.lastname: Goulielmos
authors.forename: Dimitrios T
authors.initials: DT
authors.lastname: Boumpas
authors.forename: Prodromos
authors.initials: P
authors.lastname: Sidiropoulos
authors.forename: Sophine B
authors.initials: SB
authors.lastname: Krintel
authors.forename: Lykke M
authors.initials: LM
authors.lastname: Ørnbjerg
authors.forename: Merete L
authors.initials: ML
authors.lastname: Hetland
authors.forename: Lars
authors.initials: L
authors.lastname: Klareskog
authors.forename: Thomas
authors.initials: T
authors.lastname: Haeupl
authors.forename: Andrew
authors.initials: A
authors.lastname: Filer
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Buckley
authors.forename: Karim
authors.initials: K
authors.lastname: Raza
authors.forename: Torsten
authors.initials: T
authors.lastname: Witte
authors.forename: Reinhold E
authors.initials: RE
authors.lastname: Schmidt
authors.forename: Oliver
authors.initials: O
authors.lastname: FitzGerald
authors.forename: Douglas
authors.initials: D
authors.lastname: Veale
authors.forename: Stephen
authors.initials: S
authors.lastname: Eyre
authors.forename: Jane
authors.initials: J
authors.lastname: Worthington
mesh_terms: D016022:Case-Control Studies; D005060:Europe; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2 / Q000235:genetics*; D012213:Rheumatic Fever / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C516649:PTPN2 protein, human; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2