title: Sasa quelpaertensis and p-coumaric acid attenuate oleic acid-induced lipid accumulation in HepG2 cells.
abstract: In this study, we examined the effects of Jeju dwarf bamboo (Sasa quelpaertensis Nakai) extract (JBE) and p-coumaric acid (CA) on oleic acid (OA)-induced lipid accumulation in HepG2 cells. JBE and CA increased the phosphorylation of AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC) and the expression of carnitine palmitoyl transferase 1a (CPT1a) in OA-treated HepG2 cells. Additionally, these compounds decreased sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS), and OA-induced lipid accumulation, suggesting that JBE and CA modulate lipid metabolism in HepG2 cells via the AMPK activation pathway.
authors.affiliation: Department of Biology, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Jeong-Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Seong-Il
authors.initials: SI
authors.lastname: Kang
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Shin
authors.forename: Seon-A
authors.initials: SA
authors.lastname: Yoon
authors.forename: Seung-Woo
authors.initials: SW
authors.lastname: Kang
authors.forename: Hee-Chul
authors.initials: HC
authors.lastname: Ko
authors.forename: Se-Jae
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D003373:Coumaric Acids / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D019301:Oleic Acid / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D011422:Propionates; D031787:Sasa / Q000737:chemistry*
chemical_list: D003373:Coumaric Acids; D010936:Plant Extracts; D011422:Propionates; D019301:Oleic Acid; D055372:AMP-Activated Protein Kinases; C495469:p-coumaric acid