title: [Clinical research of the relation of hepatitis B surface antigen (HBsAg) quantification and hepatic tissue pathological staging].
abstract: OBJECTIVE
  To explore the correlation of serum hepatitis B surface antigen (HBsAg) level and hepatic tissue pathological staging in the chronic hepatitis B infected persons.
  
  
  METHODS
  Collect the clinical data of 272 cases who are HBsAg-positive more than 6 months and accepted hepatic biopsy in our hospital. Detect serum HBsAg quantification, ALT, HBV DNA, complete blood count, hepatic tissue pathological staging, grouping the cases according to the stage of inflammation and the fibrosis degree respectively. Observe serum HBsAg quantification, HBV DNA and the stage of inflammation and the fibrosis degree. Analyse the correlation between HBsAg quantification and HBV DNA.
  
  
  RESULTS
  The correlation of serum HBsAg level and HBV DNA is notable. Serum HBsAg level is a variable affecting hepatic tissue pathological stage significantly.
  
  
  CONCLUSIONS
  Serum HBsAg level is a marker having higher specificity and sensitivity to diagnose the hepatic fibrosis.
authors.affiliation: Hangzhou Xi-xi Hospital, Hangzhou, China.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Yu
authors.forename: Jian-Chun
authors.initials: JC
authors.lastname: Guo
authors.forename: Yun-Hao
authors.initials: YH
authors.lastname: Xun
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Shi
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Wang
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis* / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D006801:Humans; D008099:Liver / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens