title: Phase II trial of neoadjuvant bevacizumab plus chemotherapy and adjuvant bevacizumab in patients with resectable nonsquamous non-small-cell lung cancers.
abstract: BACKGROUND
  Bevacizumab improves survival in patients with advanced non-small-cell lung cancer (NSCLC). This phase II clinical trial assessed the effects of the addition of bevacizumab to neoadjuvant chemotherapy in resectable nonsquamous NSCLC.
  
  
  METHODS
  Patients with resectable stage IB-IIIA nonsquamous NSCLC were treated with bevacizumab followed by imaging 2 weeks later to assess single-agent effect. After this they received two cycles of bevacizumab with four cycles of cisplatin and docetaxel followed by surgical resection. Resected patients were eligible for adjuvant bevacizumab. The primary endpoint was the rate of pathological downstaging (decrease from pretreatment clinical stage to post-treatment pathological stage). Secondary endpoints included overall survival, safety, and radiologic response.
  
  
  RESULTS
  Fifty patients were enrolled. Thirty-four (68%) were clinical stage IIIA. All three doses of neoadjuvant bevacizumab were delivered to 40 of 50 patients. Six patients (12%) discontinued because of bevacizumab-related adverse events. The rate of downstaging (38%), response to chemotherapy (45%), and perioperative complications (12%) were comparable with historical data. No partial responses were observed to single-agent bevacizumab, but 18% of the patients developed new intratumoral cavitation, with a trend toward improved pathologic response (57% versus 21%; p = 0.07). A major pathologic response (≥90% treatment effect) was associated with survival at 3 years (100% versus 49%; p = 0.01). No patients with KRAS-mutant NSCLC (0 of 10) had a pathologic response as compared with 11 of 31 with wild-type KRAS.
  
  
  CONCLUSIONS
  Although preoperative bevacizumab plus chemotherapy was feasible, it did not improve downstaging in unselected patients. New cavitation after single-agent bevacizumab is a potential biomarker. Alternative strategies are needed for KRAS-mutant tumors.
authors.affiliation: Department of Medicine, Division of Solid Tumor Oncology, Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, New York 10065, USA.
authors.forename: Jamie E
authors.initials: JE
authors.lastname: Chaft
authors.forename: Valerie
authors.initials: V
authors.lastname: Rusch
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Ginsberg
authors.forename: Paul K
authors.initials: PK
authors.lastname: Paik
authors.forename: David J
authors.initials: DJ
authors.lastname: Finley
authors.forename: Mark G
authors.initials: MG
authors.lastname: Kris
authors.forename: Katharine A R
authors.initials: KA
authors.lastname: Price
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Azzoli
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Fury
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Riely
authors.forename: Lee M
authors.initials: LM
authors.lastname: Krug
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Downey
authors.forename: Manjit S
authors.initials: MS
authors.lastname: Bains
authors.forename: Camelia S
authors.initials: CS
authors.lastname: Sima
authors.forename: Nabil
authors.initials: N
authors.lastname: Rizk
authors.forename: William D
authors.initials: WD
authors.lastname: Travis
authors.forename: Naiyer A
authors.initials: NA
authors.lastname: Rizvi
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011092:Polyethylene Glycols; D011994:Recombinant Proteins / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D011994:Recombinant Proteins; D042461:Vascular Endothelial Growth Factor A; D016179:Granulocyte Colony-Stimulating Factor; D000068258:Bevacizumab; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D000069585:Filgrastim