title: Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice.
abstract: Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.
authors.affiliation: Department of Histology and Embryology. School of Veterinary Sciences, National University of La Plata, 60 and 118 streets, postal code 1900, La Plata, Buenos Aires, Argentina, carozanuzzi@gmail.com.
authors.forename: Carolina
authors.initials: C
authors.lastname: Zanuzzi
authors.forename: Mariela
authors.initials: M
authors.lastname: Scrochi
authors.forename: Nadia
authors.initials: N
authors.lastname: Fuentealba
authors.forename: Fabián
authors.initials: F
authors.lastname: Nishida
authors.forename: Enrique
authors.initials: E
authors.lastname: Portiansky
authors.forename: Cecilia
authors.initials: C
authors.lastname: Muglia
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gimeno
authors.forename: Claudio
authors.initials: C
authors.lastname: Barbeito
authors.forename: Cecilia
authors.initials: C
authors.lastname: Galosi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006566:Herpesviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D004861:Herpesvirus 1, Equid / Q000145:classification / Q000235:genetics / Q000502:physiology*; D006734:Horse Diseases / Q000473:pathology / Q000821:virology*; D006736:Horses; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C