title: Preliminary results of multicenter questionnaire study on long-term outcomes of curative endoscopic submucosal dissection for early gastric cancer.
abstract: OBJECTIVE
  There are a number of published reports on long-term outcomes of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC), but most reports are from single centers with median follow-up periods shorter than 5 years. This questionnaire study investigated long-term outcomes of curative ESD for EGC at six Japanese institutions with follow-up rates of at least 90% over a minimum 5-year period.
  
  
  METHODS
  All consecutive patients with initial-onset EGC who underwent ESD through December 2006 at the six institutions were included in our study. The questionnaire covered pathological curability and long-term outcomes of patients with curative resections or curative resections for expanded indications over follow-up periods of at least 5 years.
  
  
  RESULTS
  There were 3788 patients with initial-onset EGC including 1710 (45.1%) patients with curative resections and 1289 (34.0%) patients with curative resections for expanded indications. The remaining 789 (20.8%) patients had non-curativeresections. Altogether, 1601 (93.6%) patients with curative resections and 1205 (93.5%) patients with curative resections for expanded indications were successfully followed up for at least 5 years. No recurrences were reported in any of the 1601 patients with curative resections whereas three recurrences (0.2%) were reported in the 1205 patients with curative resections for expanded indications. Gastric cancer-related deaths occurred in seven (0.2%) of the 2806 patients with curative resections or curative resections for expanded indications including six patients with metachronous gastric cancer-related deaths.
  
  
  CONCLUSIONS
  This questionnaire study's results indicated favorable long-term outcomes for patients with curative resections or curative resections for expanded indications.
authors.affiliation: Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Oda
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Oyama
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Abe
authors.forename: Ken
authors.initials: K
authors.lastname: Ohnita
authors.forename: Takashi
authors.initials: T
authors.lastname: Kosaka
authors.forename: Kingo
authors.initials: K
authors.lastname: Hirasawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishido
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Shin'ichi
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D002423:Cause of Death / Q000639:trends; D004210:Dissection / Q000379:methods*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D011795:Surveys and Questionnaires; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome
keywords: curative resection; early gastric cancer; endoscopic submucosal dissection (ESD); expanded indication; long-term outcome