title: Human cord blood-derived mononuclear cell transplantation for viral encephalitis-associated cognitive impairment: a case report.
abstract: BACKGROUND
  Herpes simplex virus is the most common cause of sporadic viral encephalitis. Cognitive impairments persist in most patients who survive herpes simplex virus-caused encephalitis after undergoing currently available treatments. This is the first report on the development of human cord blood-derived mononuclear cell transplantation as a new treatment intervention to improve the prognosis of sequelae of viral encephalitis.
  
  
  METHODS
  An 11-year-old Han Chinese boy developed sequelae of viral encephalitis with cognitive, mental and motor impairments in the 8 months following routine treatments. Since receiving allogeneic cord blood-derived mononuclear cell transplantation combined with comprehensive rehabilitation therapies 7 years ago, the patient's health has significantly improved and remained stable.
  
  
  CONCLUSIONS
  Human cord blood-derived mononuclear cell transplantation may be a potential therapeutic strategy for treating the neuropsychiatric and neurobehavioral sequelae of viral encephalitis.
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, 2/F, Yuanxing Technology Building, #1 Songpingshan Street, North Area, Hi-Tech Industrial Park, Shenzhen 518057, China. publication@beikebiotech.com.
authors.forename: Wan-Zhang
authors.initials: WZ
authors.lastname: Yang
authors.forename: Guo-Jian
authors.initials: GJ
authors.lastname: Shu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Wu
authors.forename: Bi-Yu
authors.initials: BY
authors.lastname: Ye
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu