title: Messages from molecules: deciphering the code.
abstract: Acne therapy should be based on pathogenesis. Current mainstays of therapy include topical retinoids, antibiotics, and benzoyl peroxide. Newer research has shown that inflammation may precede comedo formation. Gene array analysis of acne lesions has elucidated newer inflammatory mediators that may become future targets for therapeutic development.
authors.affiliation: Gwinnett Dermatology, Snellville, GA, USA. jsweiss@bellsouth.net
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Weiss
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000503:physiopathology; D000279:Administration, Cutaneous; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000378:metabolism; D058990:Molecular Targeted Therapy; D020411:Oligonucleotide Array Sequence Analysis; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D003879:Dermatologic Agents; D018836:Inflammation Mediators; D012176:Retinoids; D001585:Benzoyl Peroxide