title: UDP-glucuronosyltransferase 2B17 genotype and the risk of lung cancer among Austrian Caucasians.
abstract: BACKGROUND
  The enzyme uridine diphospho glucuronosyltansferase 2B17 (UGT2B17) glucuronidates several endogenous and exogenous compounds, including carcinogens from tobacco smoke like 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanl (NNAL). UGT2B17 shows a remarkable copy number variation (CNV) and an association between deletion genotype and increased risk of lung adenocarcinoma in women has been previously reported.
  
  
  METHODS
  We investigated the UGT2B17 CNV by PCR in 453 Austrian lung cancer patients and in 449 healthy donors and analyzed the impact on lung cancer susceptibility and outcome.
  
  
  RESULTS
  Copy numbers of UGT2B17 were 44.4% (+/+), 42.2% (+/-) and 13.5% (-/-) in lung cancer patients and 43.0% (+/+), 46.3% (+/-) and 10.7% (-/-) among healthy donors. The null genotype was not significantly more frequent among women with adenocarcinoma compared to healthy women (p=0.59). There was no association with overall survival (p=0.622) and no significant sex-associated (p=0.423) or histology-related impact on development of lung cancer.
  
  
  CONCLUSIONS
  UGT2B17 deletion genotype was not associated with a significant risk for lung cancer development or outcome in our Central European patient cohort. Our study indicates that UGT2B17 is not a crucial factor in lung carcinogenesis among Caucasians and shows the importance of investigating such markers in large cohorts from different populations.
authors.affiliation: Department of Medicine I, Division of Hematology and Hemostaseology, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
authors.forename: Michaela
authors.initials: M
authors.lastname: Gruber
authors.forename: Trang
authors.initials: T
authors.lastname: Le
authors.forename: Martin
authors.initials: M
authors.lastname: Filipits
authors.forename: Andrea
authors.initials: A
authors.lastname: Gsur
authors.forename: Christine
authors.initials: C
authors.lastname: Mannhalter
authors.forename: Ulrich
authors.initials: U
authors.lastname: Jäger
authors.forename: Katrina
authors.initials: K
authors.lastname: Vanura
mesh_terms: D000368:Aged; D001317:Austria / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D018628:Gene Dosage; D005838:Genotype; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D015778:Minor Histocompatibility Antigens; D012189:Retrospective Studies; D012907:Smoking / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D044465:White People / Q000235:genetics* / Q000706:statistics & numerical data
chemical_list: D015778:Minor Histocompatibility Antigens; D014453:Glucuronosyltransferase; C500513:UGT2B17 protein, human
keywords: Cancer risk; Cancer susceptibility genes; Copy number variation; Lung cancer; Polymorphisms in carcinogen metabolism; UGT2B17