title: Neonatal cord blood adiponectin and insulin levels in very low birth weight preterm and healthy full-term infants.
abstract: BACKGROUND
  There are few studies concerning adiponectin and insulin concentration in cord blood of very low birth weight (VLBW) preterm and full-term newborns, small and appropriate for gestational age (GA).
  
  
  OBJECTIVE
  To compare adiponectin and insulin concentrations between preterm and full-term infants, and to determine their relation with birth weight (BW) and size for GA.
  
  
  METHODS
  A cross-sectional study of VLBW preterm newborns with GA < 32 weeks and BW < 1500 g, and full-term newborns with GA > 37 weeks born at our hospital between January 2010 and May 2011, was conducted.
  
  
  METHODS
  major congenital malformation, inborn errors of metabolism, chromosomal anomalies. Adiponectin was determined by enzimoimunoassay with ELISA kits (R&D Systems, Minneapolis, MN) and insulin was assayed by chemiluminescence method.
  
  
  RESULTS
  A total of 127 newborns were studied, 55 VLBW preterm (28 SGA), and 72 full-term (7 SGA). Insulin cord blood concentrations in preterm and full-term newborns were similar. Adiponectin concentrations were significantly lower in preterm than in full-term infants: 1.57 ± 0.74 pg/ml versus 2.4 ± 0.22 pg/ml (p < 0.001), respectively. Regression analyses showed that, after controlling for several neonatal and maternal factors, preterm birth was the only significant predictor of adiponectin concentrations.
  
  
  CONCLUSIONS
  Being born prematurely is the main determinant factor for lower adiponectin concentration in umbilical cord blood of newborns.
authors.affiliation: Department of Pediatrics, Newborn Section, Universidade Federal do Rio Grande do Sul and Hospital de Clínicas de Porto Alegre , Brazil.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Terrazzan
authors.forename: Renato S
authors.initials: RS
authors.lastname: Procianoy
authors.forename: Rita C
authors.initials: RC
authors.lastname: Silveira
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007236:Infant, Small for Gestational Age / Q000097:blood; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008297:Male; D011247:Pregnancy; D047929:Term Birth / Q000097:blood*; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D007328:Insulin