title: Ultrasound elastography of breast lesions in chinese women: a multicenter study in China.
abstract: OBJECTIVE
  Through analysis, the elastograms characteristics of breast lesions of Chinese women, a suitable diagnostic standard of quasistatic ultrasound elastography (UE) for Chinese women was proposed.
  
  
  METHODS
  From June 2010 to March 2012, 1036 consecutive female patients (mean age, 44 years old) with breast lesions were recruited into a multicenter retrospective study, which involved 8 centers across China. Each institutional ethic review board approved the study, and all the patients gave written informed consent. All breast lesions underwent ultrasound and UE examination. Two radiologists analyzed the elastograms and separated the elastograms into 10 types. A final diagnosis was made on the basis of histologic findings. The characteristics of the elastograms were analyzed. Receiver operating characteristic curves were plotted for evaluating the diagnostic performance. Sensitivity, specificity, and accuracy were calculated. Differences in sensitivity, specificity, and accuracy were tested by using the McNemar test.
  
  
  RESULTS
  There were 1150 lesions (593 benign, 557 malignant). There was a highly significant correlation between the elastogram color distribution and the percentage of malignant lesions, with a value of 0.92 (2P < .0001). Through analysis the different malignant percentages in different elastogram types, UE diagnostic standard was proposed, which was correlated with the blue percentage in the elastogram. The specificity, sensitivity, and accuracy of UE were 86.4%, 80.8%, and 83.5%, respectively. The specificity and accuracy of UE were higher than with ultrasound. The area under the curve was 0.86.
  
  
  CONCLUSIONS
  UE could give valuable assessment in the diagnosis of breast lesions. The proposed UE diagnostic standard was suitable for Chinese women.
authors.affiliation: Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhi
authors.forename: Bing
authors.initials: B
authors.lastname: Ou
authors.forename: Xiao-yun
authors.initials: XY
authors.lastname: Xiao
authors.forename: Yu-lan
authors.initials: YL
authors.lastname: Peng
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Li-sha
authors.initials: LS
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiao
authors.forename: Shou-jun
authors.initials: SJ
authors.lastname: Liu
authors.forename: Chang-jun
authors.initials: CJ
authors.lastname: Wu
authors.forename: Yu-xin
authors.initials: YX
authors.lastname: Jiang
authors.forename: Shyam Sundar
authors.initials: SS
authors.lastname: Parajuly
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Hao
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Bao-Ming
authors.initials: BM
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000706:statistics & numerical data; D001941:Breast Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult