title: Effect of non-surgical periodontal therapy on serum ferritin levels: an interventional study.
abstract: BACKGROUND
  Ferritin, an acute-phase reactant, has been found to be elevated in many chronic inflammation-related diseases. The aim of the present study is to investigate differences in concentrations of serum ferritin in patients with and without periodontal disease before and after non-surgical periodontal therapy and correlate these values with clinical variables associated with periodontal disease.
  
  
  METHODS
  Forty-two individuals were included in this study, 20 with chronic periodontitis (CP) and 22 classified as periodontally healthy. Serum ferritin concentrations, hemoglobin levels, and periodontal parameters (probing depth [PD], clinical attachment level, gingival index, bleeding on probing, and plaque index) were recorded at baseline and 3 months after non-surgical periodontal therapy.
  
  
  RESULTS
  Patients with CP showed higher concentrations of serum ferritin than periodontally healthy controls (P <0.01). After adjustment for confounders, a positive and significant correlation was observed between serum ferritin levels and the number of sites with PD ≥ 6 mm at baseline (P <0.01). Regression analyses revealed association between deep pockets and serum ferritin levels at baseline (R(2) = 0.823). Significant reductions in serum ferritin levels were observed at the 3-month assessment after periodontal treatment (P <0.01), and the post-treatment serum ferritin values were comparable to those of controls (P >0.05). Furthermore, the post-treatment degree of change in the serum ferritin level was positively and significantly associated with improvement in PD (R(2) = 0.213, P <0.05).
  
  
  CONCLUSIONS
  Serum ferritin levels are raised in patients with CP and decrease to control levels post-treatment.
authors.affiliation: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors.forename: Souvik
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Shikha
authors.initials: S
authors.lastname: Tewari
authors.forename: Rajinder Kumar
authors.initials: RK
authors.lastname: Sharma
authors.forename: Satish Chander
authors.initials: SC
authors.lastname: Narula
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood / Q000628:therapy*; D003774:Dental Plaque Index; D005260:Female; D005293:Ferritins / Q000097:blood*; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood / Q000628:therapy; D057747:Periodontal Debridement / Q000379:methods*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000628:therapy; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D005293:Ferritins