title: [Association of lipid metabolism disorder with peritoneum transport ability and mortality in peritoneal dialysis patients].
abstract: OBJECTIVE
  To observe the features of lipid metabolism disorders of peritoneal dialysis(PD)patients and hemodialysis(HD)patients and explore the association of lipid metabolism disorder with peritoneum transport ability and mortality.
  
  
  METHODS
  The clinical data of 127 PD patients and 95 HD patients who had received regular dialysis for more than 3 months in Peking Union Medical College Hospital since March 2009 were retrospectively analyzed.Serum lipid profiles were tested.Serum hypersensitive C reactive protein(hsCRP)was examined by immune turbidimetric method.Serum carbohydrate antigen 125(CA125)and iPTH were detected by electrochemical luminescence method.Peritoneum transport ability was evaluated through peritoneal equilibration test(PET).After a 2-year follow-up,the levels of CA125 and the peritoneum transport abilities were compared between the baseline data and the end point,and the relationship between lipid disorder and the mortality was analyzed.
  
  
  RESULTS
  After the 2-year follow-up,25(19.7%)PD patients died.The leading cause of death was congestive heart failure(56.0%),followed by myocardial infarction(12.0%),septic shock(12.0%),respiratory failure(8.0%),asphyxiation(8.0%),and gastrointestinal bleeding(4.0%).Compared with the survivors,the death patients were older(P=0.005),with significant lower albumin level(P=0.000)and pre-albumin level(P=0.001).However,there was no significant difference in other clinical features including body mass index(BMI),blood pressure,dialysis time,nPCR,iPTH,hemoglobin,hsCRP,and serum lipid level(all P>0.05).COX regression analysis showed that diabetes mellitus(P=0.030)and mean SBP(P=0.048)were significantly associated with the mortality of PD patients.At the baseline,the CA125 level in patients with high,high average,and low average transport status of peritoneum was(38.02±64.37),(21.21±19.41),and(17.55±23.2)U/ml,respectively(P=0.09).There was no association between the transport status and lipid(TC,TG and LDL).
  
  
  CONCLUSIONS
  Congestive heart failure is the leading cause of death among PD patients.Diabetes and blood pressure are the dependent risk factors of mortality.Lipid disorder is associated with CA125,while its association with peritoneum transport ability or mortality was not found.
authors.affiliation: Department of Nephrology,PUMC Hospital,CAMS and PUMC, Beijing,China.
authors.forename: Yan-hui
authors.initials: YH
authors.lastname: Fang
authors.forename: Lan-ping
authors.initials: LP
authors.lastname: Jiang
authors.forename: Zi-juan
authors.initials: ZJ
authors.lastname: Zhou
authors.forename: Hai-yun
authors.initials: HY
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Li
authors.forename: Li-meng
authors.initials: LM
authors.lastname: Chen
authors.forename: Xue-wang
authors.initials: XW
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D002423:Cause of Death; D005260:Female; D017583:Hemodiafiltration / Q000401:mortality; D006801:Humans; D052439:Lipid Metabolism Disorders / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000401:mortality*; D010537:Peritoneum / Q000378:metabolism / Q000503:physiopathology*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein