title: RAS does not regulate all PI3K isoforms.
abstract: RAC1 and CDC42, but not RAS, bind and activate p110β through its RAS-binding domain.
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D058543:Class Ia Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011485:Protein Binding; D020033:Protein Isoforms / Q000378:metabolism; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D020744:rac GTP-Binding Proteins / Q000378:metabolism; D020830:rac1 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C099818:DOCK1 protein, human; C465214:ELMO1 protein, human; D020033:Protein Isoforms; C107953:RAC1 protein, human; D019869:Phosphatidylinositol 3-Kinases; D058543:Class Ia Phosphatidylinositol 3-Kinase; D020744:rac GTP-Binding Proteins; D020830:rac1 GTP-Binding Protein; D018631:ras Proteins