title: Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine.
abstract: Clostridium difficile is a leading cause of severe nosocomial infections. Cell-surface carbohydrate antigens are promising vaccine candidates. Here we report the first total synthesis of oligomers of the lipoteichoic acid antigen repeating unit. Synthetic glycan microarrays revealed anti-glycan antibodies in the blood of patients that help to define epitopes for vaccine development.
authors.affiliation: Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Martin
authors.forename: Felix
authors.initials: F
authors.lastname: Broecker
authors.forename: Steffen
authors.initials: S
authors.lastname: Eller
authors.forename: Matthias A
authors.initials: MA
authors.lastname: Oberli
authors.forename: Chakkumkal
authors.initials: C
authors.lastname: Anish
authors.forename: Claney L
authors.initials: CL
authors.lastname: Pereira
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
mesh_terms: D001428:Bacterial Vaccines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016360:Clostridioides difficile / Q000187:drug effects; D006801:Humans; D008070:Lipopolysaccharides / Q000138:chemical synthesis / Q000737:chemistry*; D046228:Microarray Analysis; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D013682:Teichoic Acids / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; D011134:Polysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid