title: Mesoscale modulation of supramolecular ureidopyrimidinone-based poly(ethylene glycol) transient networks in water.
abstract: In natural systems, highly synergistic non-covalent interactions among biomolecular components exert mesoscopic control over hierarchical assemblies. We herein present a multicomponent self-assembly strategy to tune hierarchical supramolecular polymer architectures in water using highly affine and directional ureidopyrimidinone-poly(ethylene glycol)s (UPy-PEG). Using scattering methods and oscillatory rheology, we observe the structural and mechanical regulation of entangled monofunctional UPy-PEG fibrils by cross-linking bifunctional UPy-PEG fibrils. This supramolecular mixing approach opens the door to a range of subtly distinct materials for chemical and biological applications.
authors.affiliation: Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: Roxanne E
authors.initials: RE
authors.lastname: Kieltyka
authors.forename: A C H
authors.initials: AC
authors.lastname: Pape
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Albertazzi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakano
authors.forename: Maartje M C
authors.initials: MM
authors.lastname: Bastings
authors.forename: Ilja K
authors.initials: IK
authors.lastname: Voets
authors.forename: Patricia Y W
authors.initials: PY
authors.lastname: Dankers
authors.forename: E W
authors.initials: EW
authors.lastname: Meijer
mesh_terms: D002219:Carbamates / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011092:Polyethylene Glycols / Q000737:chemistry*; D011744:Pyrimidinones / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D002219:Carbamates; D011744:Pyrimidinones; D014867:Water; D011092:Polyethylene Glycols; D014508:Urea