title: The MULE/HUWE1 E3 ubiquitin ligase is a tumor suppressor.
abstract: MULE/HUWE1 suppresses RAS-driven skin tumorigenesis in vivo by regulating c-MYC/MIZ1 stability.
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D059447:Cell Cycle Checkpoints; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D025521:Tumor Suppressor Proteins; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism*
chemical_list: D051741:Kruppel-Like Transcription Factors; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D025521:Tumor Suppressor Proteins; C107961:ZBTB17 protein, human; C502830:HUWE1 protein, human; D044767:Ubiquitin-Protein Ligases