title: The expression and immunohistochemical localization of periostin in odontogenic tumors of mixed epithelial/mesenchymal origin.
abstract: OBJECTIVE
  The object of this study was to determine the expression and localization of periostin in the major mixed odontogenic tumors and to correlate any differential staining of the mesenchymal components to the interrelationship of these tumors.
  
  
  METHODS
  Five ameloblastic fibromas, 8 ameloblastic fibro-odontomas and 10 odontomas were assessed immunohistochemically for periostin staining. Because mesenchymal tissues were consistently present in all studied cases, these tissues were selected for statistical analysis of differential periostin staining.
  
  
  RESULTS
  Periostin was variably localized to the mesenchymal component of the tumors as well as to preameloblasts and ameloblasts. Analysis of the mesenchymal staining intensity was statistically significantly different between ameloblastic fibro-odontomas and odontomas (P < .001; Dunn multiple comparisons test).
  
  
  CONCLUSIONS
  Our results document periostin staining in human mixed odontogenic tumors. Statistical analysis of differential stromal staining supports the concept that the ameloblastic fibroma is a histogenetically distinct neoplasm as compared to ameloblastic fibro-odontoma and odontoma.
authors.affiliation: Division of Oral and Maxillofacial Surgery, Schulich Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Chau
authors.forename: T
authors.initials: T
authors.lastname: Daley
authors.forename: M R
authors.initials: MR
authors.lastname: Darling
authors.forename: D
authors.initials: D
authors.lastname: Hamilton
mesh_terms: D000293:Adolescent; D000328:Adult; D000565:Ameloblasts / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004396:Coloring Agents; D004848:Epithelium / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008648:Mesoderm / Q000473:pathology; D009808:Odontogenic Tumors / Q000473:pathology*; D009810:Odontoma / Q000473:pathology; D017154:Stromal Cells / Q000473:pathology; D055815:Young Adult
chemical_list: D015815:Cell Adhesion Molecules; D004396:Coloring Agents; C512835:POSTN protein, human