title: High-Affinity SIRPα Variants Potentiate Antibody Therapy Efficacy.
abstract: SIRPα variants with high CD47 affinity enhance the antitumor activity of therapeutic antibodies.
mesh_terms: D000912:Antibodies, Neoplasm / Q000276:immunology / Q000627:therapeutic use*; D000943:Antigens, Differentiation / Q000276:immunology / Q000378:metabolism*; D051928:CD47 Antigen / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D010587:Phagocytosis / Q000276:immunology; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000912:Antibodies, Neoplasm; D000943:Antigens, Differentiation; D051928:CD47 Antigen; D011971:Receptors, Immunologic; C501920:SIRPA protein, human