title: Diagnosis and treatment of placental site trophoblastic tumor.
abstract: Here we report a case of a placental site trophoblastic tumor in a 36 year old Chinese woman, 31 months following a prior normal pregnancy. Her clinical presentation and ultrasound findings were uncharacteristic; and the final definitive diagnosis was established based on histological examination in conjunction with immunohistochemistry studies and a normal beta human chorionic gonadotropin level. The tumor exhibited high grade histological features with tumor necrosis, nuclear atypia and high mitosis. The patient was successfully treated with hysterectomy with pre- and post-operative chemotherapy.
authors.affiliation: Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China, 410011.
authors.forename: Fengying
authors.initials: F
authors.lastname: Huang
authors.forename: Wenli
authors.initials: W
authors.lastname: Zheng
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Liang
authors.forename: Tuanfang
authors.initials: T
authors.lastname: Yin
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D008940:Mitotic Index; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D011247:Pregnancy; D016896:Treatment Outcome; D018245:Trophoblastic Tumor, Placental Site / Q000097:blood / Q000737:chemistry / Q000175:diagnosis* / Q000628:therapy*; D014594:Uterine Neoplasms / Q000097:blood / Q000737:chemistry / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin
keywords: Placental site trophoblastic tumor (PSTT); diagnosis; gestational trophoblastic neoplasm (GTN); treatment