title: The differences between ICL repair during and outside of S phase.
abstract: DNA interstrand crosslinks (ICLs) are complex lesions that block essential DNA transactions including DNA replication, recombination, and RNA transcription. Naturally occurring ICLs are rare, yet these lesions are the major cause of toxicity following treatment with several classes of crosslinking cancer chemotherapeutic drugs. ICLs are repaired during and outside of S phase by pathways with overlapping as well as distinct features. Here, we discuss some recent insights into the mechanisms of replication-dependent and replication-independent repair of ICLs with special emphasis on the differences between these repair pathways.
authors.affiliation: Department of Genetics and Development, Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
authors.forename: Hannah L
authors.initials: HL
authors.lastname: Williams
authors.forename: Max E
authors.initials: ME
authors.lastname: Gottesman
authors.forename: Jean
authors.initials: J
authors.lastname: Gautier
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D002453:Cell Cycle; D003432:Cross-Linking Reagents / Q000009:adverse effects / Q000633:toxicity; D004249:DNA Damage; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D059767:Recombinational DNA Repair; D016196:S Phase
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D045643:DNA Repair Enzymes