title: Genetic analysis of leukosis incidence in United States Holstein and Jersey populations.
abstract: Bovine leukosis (BL) is a retroviral disease caused by the bovine leukosis virus that affects only cattle. It is associated with decreased milk production and increased cull rates due to development of lymphosarcoma. The virus also affects the immune system. Infected cows display a weak response to some vaccinations. It is important to determine if the heritability of BL susceptibility is greater than zero, or if the environment is the only factor that can be used to reduce the transmission and incidence of the disease. Accordingly, the aim of this study was to estimate the heritability for BL incidence and the genetic merit of sires for leukosis resistance in Holstein and Jersey cattle. Continuous scores and binary milk ELISA results for 13,217 Holstein cows from 114 dairy herds across 16 states and 642 Jersey cows from 8 dairy herds were considered. Data were obtained from commercial testing records at Antel BioSystems (Lansing, MI). Out of the 13,859 animals tested, 38% were found to be infected with the disease. Linear and threshold animal models were used to analyze the continuous and binary data, respectively. Results from both models were similar in terms of estimated breeding values and variance components in their respective scales. Estimates of heritability obtained with the 2 approaches were approximately 8% for both breeds, indicating a considerable genetic component underlying BL disease incidence. The correlation between the estimated breeding values from the 2 models was larger than 0.90, and the lists of top 10% bulls selected from each model had about 80% overlap for both breeds. In summary, results indicate that a simple linear model using the continuous ELISA scores as the response variable was a reasonable approach for the genetic analysis of BL incidence in cattle. In addition, the levels of heritability found indicate that genetic selection could also be used to decrease susceptibility to bovine leukosis virus infection in Holstein and Jersey cattle. Further research is necessary to investigate the genetic correlations of BL with other production and reproduction traits, and to search for potential genomic regions harboring major genes affecting BL susceptibility.
authors.affiliation: Department of Animal Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA. eabdalla@wisc.edu
authors.forename: E A
authors.initials: EA
authors.lastname: Abdalla
authors.forename: G J M
authors.initials: GJ
authors.lastname: Rosa
authors.forename: K A
authors.initials: KA
authors.lastname: Weigel
authors.forename: T
authors.initials: T
authors.lastname: Byrem
mesh_terms: D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics; D003612:Dairying / Q000706:statistics & numerical data; D016583:Enzootic Bovine Leukosis / Q000453:epidemiology / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D015994:Incidence; D001909:Leukemia Virus, Bovine / Q000235:genetics; D008297:Male; D008892:Milk / Q000737:chemistry; D010375:Pedigree; D019655:Quantitative Trait, Heritable; D014481:United States / Q000453:epidemiology
keywords: bovine leukosis; heritability; milk ELISA; threshold model