title: Lactobacillus sakei lipoteichoic acid inhibits MMP-1 induced by UVA in normal dermal fibroblasts of human.
abstract: Human skin is continuously exposed to ultraviolet (UV)-induced photoaging. UVA increases the activity of MMP-1 in dermal fibroblasts through mitogen-activated protein kinase (MAPK), p38, signaling. The irradiation of keratinocytes by UVA results in the secretion of the inflammatory cytokine, tumor necrosis factor-α (TNF-α), and the stimulation of MMP-1 in normal human dermal fibroblasts (NHDFs). Lipoteichoic acid (LTA) is a component of the cell wall of gram-positive Lactobacillus spp. of bacteria. LTA is well known as an anti-inflammation molecule. LTA of the bacterium Lactobacillus plantarum has an anti-photoaging effect, but the potential anti-photoaging effect of the other bacteria has not been examined to date. The current study showed that L. sakei LTA (sLTA) has an immune modulating effect in human monocyte cells. Our object was whether inhibitory effects of sLTA on MMP-1 are caused from reducing the MAPK signal in NHDFs. It inhibits MMP-1 and MAPK signaling induced by UVA in NHDFs. We also confirmed effects of sLTA suppressing TNF-α inducing MMP-1 in NHDFs.
authors.affiliation: School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 449-701, Republic of Korea.
authors.forename: Ga-Eun
authors.initials: GE
authors.lastname: You
authors.forename: Bong-Jun
authors.initials: BJ
authors.lastname: Jung
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Kim
authors.forename: Han-Geun
authors.initials: HG
authors.lastname: Kim
authors.forename: Tae-Rahk
authors.initials: TR
authors.lastname: Kim
authors.forename: Dae-Kyun
authors.initials: DK
authors.lastname: Chung
mesh_terms: D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000378:metabolism*; D005347:Fibroblasts / Q000201:enzymology / Q000382:microbiology* / Q000528:radiation effects*; D006801:Humans; D048191:Lactiplantibacillus plantarum / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000378:metabolism*; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis*; D015398:Signal Transduction / Q000187:drug effects; D013682:Teichoic Acids / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: D004791:Enzyme Inhibitors; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid; D020781:Matrix Metalloproteinase 1