title: Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning.
abstract: Metabotropic glutamate (mGlu) receptors impact learning and memory. Although some evidence indicates the importance of these receptors in conditioned taste aversion (CTA), the subtype-specific involvement of mGlu receptors in this associative learning task remains to be determined. These experiments examined the effects of (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268), a selective group II mGlu receptor agonist, cis-2-[[(3,5-dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid (VU0155041), a mGlu4 positive allosteric modulator, N,N'-dibenzhydrylethane-1,2-diamine (AMN082), a mGlu7 allosteric agonist, and 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP), a mGlu7 negative allosteric modulator, on the acquisition of CTA using male Sprague-Dawley rats. Systemic injections of LY379268, AMN082, and MMPIP prior to conditioning decreased the acquisition of CTA, revealing that mGlu2/3 and mGlu7 are involved in CTA learning.
authors.affiliation: Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA.
authors.forename: D
authors.initials: D
authors.lastname: Klakotskaia
authors.forename: A K
authors.initials: AK
authors.lastname: Ramsey
authors.forename: S W
authors.initials: SW
authors.lastname: Fowler
authors.forename: P
authors.initials: P
authors.lastname: Serfozo
authors.forename: A
authors.initials: A
authors.lastname: Simonyi
authors.forename: T R
authors.initials: TR
authors.lastname: Schachtman
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000813:Anilides / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology; D003463:Cues; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology*; D008024:Ligands; D008297:Male; D011728:Pyridones / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D012439:Saccharin / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*
chemical_list: C553164:6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo(4,5-c)pyridin-4(5H)-one; D000596:Amino Acids; D000813:Anilides; D001559:Benzhydryl Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003509:Cyclohexanecarboxylic Acids; D018683:Excitatory Amino Acid Agents; C118218:LY 379268; D008024:Ligands; C507346:N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride; D011728:Pyridones; D018094:Receptors, Metabotropic Glutamate; D013549:Sweetening Agents; C544970:VU 0155041; D012439:Saccharin
keywords: AMN082; Conditioned taste aversion; LY379268; MMPIP; Metabotropic glutamate receptor; VU0155041