title: Poxvirus DNA replication.
abstract: Poxviruses are large, enveloped viruses that replicate in the cytoplasm and encode proteins for DNA replication and gene expression. Hairpin ends link the two strands of the linear, double-stranded DNA genome. Viral proteins involved in DNA synthesis include a 117-kDa polymerase, a helicase-primase, a uracil DNA glycosylase, a processivity factor, a single-stranded DNA-binding protein, a protein kinase, and a DNA ligase. A viral FEN1 family protein participates in double-strand break repair. The DNA is replicated as long concatemers that are resolved by a viral Holliday junction endonuclease.
authors.affiliation: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. bmoss@nih.gov
authors.forename: Bernard
authors.initials: B
authors.lastname: Moss
mesh_terms: D042003:DNA Packaging / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D004279:DNA, Viral / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D016679:Genome, Viral / Q000235:genetics*; D008954:Models, Biological; D011212:Poxviridae / Q000235:genetics / Q000502:physiology*
chemical_list: D004279:DNA, Viral; D004268:DNA-Binding Proteins