title: ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.
authors.affiliation: Department of Biochemistry, University of Leicester, Leicester, UK. mv62@le.ac.uk.
authors.forename: Meike
authors.initials: M
authors.lastname: Vogler
authors.forename: David
authors.initials: D
authors.lastname: Dinsdale
authors.forename: Martin J S
authors.initials: MJ
authors.lastname: Dyer
authors.forename: Gerald M
authors.initials: GM
authors.lastname: Cohen
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D001792:Blood Platelets / Q000378:metabolism*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors*; D013449:Sulfonamides / Q000494:pharmacology*; D051020:bcl-X Protein / Q000378:metabolism
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D019253:Proto-Oncogene Proteins c-bcl-2; D013449:Sulfonamides; D051020:bcl-X Protein; C579720:venetoclax
keywords: ABT-199; BCL-XL (BCL2L1); BCL2; apoptosis; chronic lymphocytic leukaemia