title: Drug-delivery systems of green tea catechins for improved stability and bioavailability.
abstract: Numerous studies in humans, animal models and cell lines have suggested the potential benefits from the consumption of green tea polyphenols, including prevention of cancer and heart diseases. However these potential effects have been strongly limited by green tea catechins low bioavailability, which hinders the development of therapeutic applications. In this review formulations that are being proposed for delivery of green tea catechins are discussed. New delivery systems are presented as valid alternatives to overcome the limitations such as green tea catechins poor stability or intestinal absorption.
authors.affiliation: Centro de Investigação em Ciências da Saúde (CICS), Instituto Superior de Ciências da Saúde - Norte, CESPU. Rua Central de Gandra, 1317. 4585-116 Gandra PRD, Portugal. jose.andrade@iscsn.cespu.pt.
authors.forename: C F
authors.initials: CF
authors.lastname: Rodrigues
authors.forename: K
authors.initials: K
authors.lastname: Ascenção
authors.forename: F A M
authors.initials: FA
authors.lastname: Silva
authors.forename: B
authors.initials: B
authors.lastname: Sarmento
authors.forename: M B P P
authors.initials: MB
authors.lastname: Oliveira
authors.forename: J C
authors.initials: JC
authors.lastname: Andrade
mesh_terms: D000818:Animals; D001682:Biological Availability; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013662:Tea / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D011108:Polymers; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate