title: Biomimetic materials and scaffolds for myocardial tissue regeneration.
abstract: One of the main challenges in tissue engineering/regenerative medicine (TERM) is the repair of damaged heart tissue, avoiding or minimizing ventricular remodeling which leads to ventricular dilatation and hypertrophy, sphericity increase, and functionality loss. Several approaches have been described to restore or enhance the contractility of the failing heart. One of them is based on the fabrication of 3D substrates that can be implanted in the infarcted area to provide an efficient support to the regenerative process. This review focuses on the strategies adopted to design and realize polymeric scaffolds for heart TERM. The implementation of different polymers and the design of scaffold architecture are described.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Silvestri
authors.forename: Monica
authors.initials: M
authors.lastname: Boffito
authors.forename: Susanna
authors.initials: S
authors.lastname: Sartori
authors.forename: Gianluca
authors.initials: G
authors.lastname: Ciardelli
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis*; D002318:Cardiovascular Diseases / Q000628:therapy; D048091:Guided Tissue Regeneration / Q000379:methods*; D006321:Heart / Q000254:growth & development*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D037742:Nanotubes, Carbon; D011108:Polymers / Q000138:chemical synthesis; D011327:Printing; D044968:Regenerative Medicine; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D037742:Nanotubes, Carbon; D011108:Polymers
keywords: biomaterials; biomimetics; cardiac tissue engineering/regenerative medicine; extracellular matrix; scaffolds