title: Angiotensin receptor blocker (ARB)-diuretic versus ARB-calcium channel blocker combination therapy for hypertension uncontrolled by ARB monotherapy.
abstract: Diuretics or calcium channel blockers (CCBs) are used concomitantly with an angiotensin II receptor blocker (ARB). However, it is not established which ARB-based combination therapy is the most effective and safe. This prospective randomized open-label study compared the efficacy and safety of a fixed-dose tablet of losartan (LST)-hydrochlorothiazide (HCTZ) (n = 99) and LST-amlodipine (AML) (n = 77) in Japanese patients whose hypertension was uncontrolled by ARB monotherapy. Blood pressure changed similarly over the 12-month study period. Only LST-HCTZ significantly increased serum uric acid (SUA) in patients with low baseline SUA (<5.6 mg/dL) but not in patients with high baseline SUA.
authors.affiliation: Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine , Yokohama , Japan .
authors.forename: Jin
authors.initials: J
authors.lastname: Oshikawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Toya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Morita
authors.forename: Masataka
authors.initials: M
authors.lastname: Taguri
authors.forename: Kazushige
authors.initials: K
authors.lastname: Hanaoka
authors.forename: Toshio
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Kazo
authors.initials: K
authors.lastname: Kaizu
authors.forename: Kouju
authors.initials: K
authors.lastname: Kamata
authors.forename: Shuzo
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Takayasu
authors.initials: T
authors.lastname: Ohtake
authors.forename: Takeo
authors.initials: T
authors.lastname: Sato
authors.forename: Gen
authors.initials: G
authors.lastname: Yasuda
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kimura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Umemura
mesh_terms: D000328:Adult; D000368:Aged; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D004232:Diuretics / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D019808:Losartan / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D002121:Calcium Channel Blockers; D004232:Diuretics; D006852:Hydrochlorothiazide; D014527:Uric Acid; D019808:Losartan
keywords: Angiotensin receptor antagonists; combination; comparative study; drug therapy; hypertension; sodium chloride symporter inhibitors