title: [Cytogenetic analysis of 105 new human abnormal karyotypes].
abstract: To analyze the genetic effect of the abnormal chromosome karyotype, we summarized and studied the clinical data of the new abnormal karyotypes diagnosed at the Guangxi Zhuang Autonomous Region Women and Children Care Hospital from January 2009 to July 2012. The samples were cultured routinely for the karyotype analysis using G banding and C banding. Chromosomal aberrations were named according to the International System for Human Cytogenetic Nomenclature (ISCN 2009). Among tested samples, 105 new human abnormal karyotypes were identified (86 reciprocal translocation, 10 chromosomal inversion, six derivative chromosome, one duplication, one isochromosome, one partial trisomy and monosomy). The results suggest that chromosomal abnormalities were a major cause of miscarriage, infertility, congenital abnormalities, mental retardation and amenorrhea in humans.
authors.affiliation: Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, China. oushangenetics@yahoo.com.cn
authors.forename: Shan
authors.initials: S
authors.lastname: Ou
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Shao-Ke
authors.initials: SK
authors.lastname: Chen
authors.forename: Chen-Guang
authors.initials: CG
authors.lastname: Zheng
authors.forename: Da-Hua
authors.initials: DH
authors.lastname: Meng
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Qing-Ming
authors.initials: QM
authors.lastname: Qiu
authors.forename: Tian-Sheng
authors.initials: TS
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Tang
mesh_terms: D059786:Abnormal Karyotype; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D025063:Chromosome Disorders / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics; D020732:Cytogenetic Analysis; D005260:Female; D005826:Genetics, Medical; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D055815:Young Adult