title: Recent developments in nanoparticle-based siRNA delivery for cancer therapy.
abstract: RNA interference (RNAi) is a gene regulation mechanism initiated by RNA molecules that enables sequence-specific gene silencing by promoting degradation of specific mRNAs. Molecular therapy using small interfering RNA (siRNA) has shown great therapeutic potential for diseases caused by abnormal gene overexpression or mutation. The major challenges to application of siRNA therapeutics include the stability and effective delivery of siRNA in vivo. Important progress in nanotechnology has led to the development of efficient siRNA delivery systems. In this review, the authors discuss recent advances in nanoparticle-mediated siRNA delivery and the application of siRNA in clinical trials for cancer therapy. This review will also offer perspectives on future applications of siRNA therapeutics.
authors.affiliation: Department of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of Korea.
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Tae-Jong
authors.initials: TJ
authors.lastname: Yoon
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Cho
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D018014:Gene Transfer Techniques / Q000639:trends*; D006801:Humans; D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000378:metabolism*
chemical_list: D008055:Lipids; D034741:RNA, Small Interfering