title: Severe hidradenitis suppurativa treatment using platelet-rich plasma gel and Hyalomatrix.
abstract: Hidradenitis suppurativa (HS) can be a debilitating chronic disease. The underlying cause of the disease is still not clear. HS may be managed through numerous different medical or surgical procedures. Surgical treatment may consist of local excisions and reconstruction using a variety of methods: perforator flaps, skin grafts, local flaps, primary closure or secondary wound healing with vacuum and other devices. This report describes our experience with surgical excision and closure using platelet-rich plasma (PRP) gel and Hyalomatrix PA (HPA) in a patient with severe HS involving most of the body surface. We treated the patient with resection of severe HS of the nuchae and closure with PRP gel prepared with the RegenKit(®) to promote neovascularisation and HPA, a delivery system for hyaluronic acid, to induce a neodermis at the wound bed and to stimulate regeneration in a humid and protected environment. Complete wound healing was achieved after 2 months. The obtained result proved the efficacy of this treatment without complications. No recurrence was observed during the 1 year after the surgical procedure. Severe HS can be safely and effectively managed with wide excision, PRP gel and Hyalomatrix to achieve a successful outcome.
authors.affiliation: Department of Plastic and Reconstructive Surgery, 'Policlinico Casilino' University of Tor Vergata in Rome, Rome, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Nicoli
authors.affiliation: Department of Plastic and Reconstructive Surgery, 'Policlinico Casilino' University of Tor Vergata in Rome, Rome, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Balzani
authors.affiliation: Plastic and Reconstructive Surgery Unit, Hospital of Pisa, Pisa, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Lazzeri
authors.affiliation: Department of Plastic and Reconstructive Surgery, 'Policlinico Casilino' University of Tor Vergata in Rome, Rome, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Gentile
authors.affiliation: Department of Plastic and Reconstructive Surgery, Maharashtra University of Health Sciences, Nashik, India.
authors.forename: Ram M
authors.initials: RM
authors.lastname: Chilgar
authors.affiliation: Department of Plastic and Reconstructive Surgery, 'Policlinico Casilino' University of Tor Vergata in Rome, Rome, Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Di Pasquali
authors.affiliation: Department of Immunology, 'La Sapienza' University, Rome, Italy.
authors.forename: Marzia
authors.initials: M
authors.lastname: Nicoli
authors.affiliation: Department of Plastic and Reconstructive Surgery, 'Policlinico Casilino' University of Tor Vergata in Rome, Rome, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bocchini
authors.affiliation: Department of Plastic and Reconstructive Surgery, 'Policlinico Casilino' University of Tor Vergata in Rome, Rome, Italy.
authors.forename: Annarita
authors.initials: A
authors.lastname: Agovino
authors.affiliation: Department of Plastic and Reconstructive Surgery, 'Policlinico Casilino' University of Tor Vergata in Rome, Rome, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Cervelli
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005782:Gels; D017497:Hidradenitis Suppurativa / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D006820:Hyaluronic Acid; D008297:Male; D053657:Platelet-Rich Plasma; D019651:Plastic Surgery Procedures / Q000379:methods*; D012720:Severity of Illness Index; D016038:Skin Transplantation / Q000379:methods*; D014945:Wound Healing
chemical_list: D005782:Gels; D006820:Hyaluronic Acid
keywords: Hidradenitis suppurativa; Hyalomatrix; Hyaluronic acid; PRP gel; Platelet-rich plasma