title: First confirmation by genotyping of transplacental choriocarcinoma transmission.
abstract: A mother developed multimetastatic gestational choriocarcinoma 13 months after delivery, and her infant died aged 11 months from the same tumor. The transplacental choriocarcinoma transmission was confirmed by genotyping. Henceforth, we recommend a 2-year maternal human chorionic gonadotropin follow-up after neonatal choriocarcinoma and extensive imaging if the human chorionic gonadotropin rises.
authors.affiliation: Department of Obstetrics and Gynecology, French Trophoblastic Disease Reference Center, Lyon Sud University Hospital, Lyon 1 Claude Bernard University, Pierre-Bénite, France.
authors.forename: Pierre-Adrien
authors.initials: PA
authors.lastname: Bolze
authors.forename: Béatrice
authors.initials: B
authors.lastname: Weber
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Fisher
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Seckl
authors.forename: François
authors.initials: F
authors.lastname: Golfier
mesh_terms: D014408:Biomarkers, Tumor; D002822:Choriocarcinoma / Q000097:blood / Q000235:genetics / Q000556:secondary*; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000097:blood / Q000235:genetics / Q000556:secondary*; D008297:Male; D008431:Maternal-Fetal Exchange; D009362:Neoplasm Metastasis; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood / Q000235:genetics / Q000473:pathology*; D014594:Uterine Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin
keywords: choriocarcinoma; chorionic gonadotropin; genotyping; gestational trophoblastic disease; neoplasm metastasis