title: N-terminal pro-brain natriuretic peptide levels and abnormal geometric patterns of left ventricle in untreated hypertensive patients.
abstract: N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts cardiovascular events and mortality in hypertensive patients. Relationship between NT-proBNP level and left ventricular (LV) hypertrophy is well known in hypertensive patients. However, the studies investigating relationship between LV geometric patterns and serum NT-proBNP level have conflicting results and are in a limited number. The goal of the present study is to investigate relation between NT-proBNP and abnormal LV geometric patterns in untreated hypertensive patients. Measurements were obtained from 273 patients with untreated essential hypertension (mean age = 51.7 ± 5.8 years) and 44 healthy control subjects (mean age; 51.3 ± 4.7). Four different geometric patterns (NG: normal geometry; CR: concentric remodelling; EH: eccentric hypertrophy; CH: concentric hypertrophy) were determined according to LV mass index (LVMI) and relative wall thickness. NT-proBNP and other biochemical markers were measured in all subjects. The highest NT-proBNP levels were determined in the CH group compared with the control group and other geometric patterns (p < 0.05). NT-proBNP levels of all geometric patterns were higher than the control group (p < 0.05, for all). NT-proBNP levels were similar between CR and NG groups (p > 0.05). NT-proBNP was independently associated with LV geometry (β = 0.304, p = 0.003) and LVMI (β = 0.266, p = 0.007) in multiple linear regression analysis. Serum NT-proBNP level was independently associated with LVMI and LV geometry in untreated hypertensive patients with preserved ejection fraction.
authors.affiliation: Department of Cardiology and.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Durmuş Yıldıray
authors.initials: DY
authors.lastname: Sahin
authors.forename: Sinan
authors.initials: S
authors.lastname: Kırım
authors.forename: Selahattin
authors.initials: S
authors.lastname: Akyol
authors.forename: Osman
authors.initials: O
authors.lastname: Kuloğlu
authors.forename: Nermin Yıldız
authors.initials: NY
authors.lastname: Koyunsever
authors.forename: Taner
authors.initials: T
authors.lastname: Seker
authors.forename: Ali
authors.initials: A
authors.lastname: Kıvrak
authors.forename: Murat
authors.initials: M
authors.lastname: Caylı
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain