title: Natural and experimental poisoning of goats with the pyrrolizidine alkaloid-producing plant Crotalaria retusa L.
abstract: Crotalaria retusa L. (rattleweed), estimated to contain about 4.96% monocrotaline (MCT) in the seed, was associated with a natural poisoning outbreak in goats. The poisoning was experimentally reproduced by the administration of C. retusa seeds containing approximately 4.49% of MCT. Thus, 1 of 3 goats given a single dose of 5 g/kg bodyweight (bw) of seeds (248 mg MCT/kg bw) and 2 goats given a single dose of 347 mg MCT/kg bw showed acute clinical signs and were euthanized 10-11 days after dosing. Clinical signs and gross and histologic lesions were characteristic of acute centrilobular liver necrosis.
authors.affiliation: 1Franklin Riet-Correa, Veterinary Hospital, CSTR, Federal University of Campina Grande, Campus de Patos, Patos, Paraiba 58700-000, Brazil. franklin.riet@pq.cnpq.br.
authors.forename: Lisanka A
authors.initials: LA
authors.lastname: Maia
authors.forename: Ricardo B
authors.initials: RB
authors.lastname: de Lucena
authors.forename: Verônica M da T
authors.initials: VM
authors.lastname: Nobre
authors.forename: Antônio F M
authors.initials: AF
authors.lastname: Dantas
authors.forename: Steven M
authors.initials: SM
authors.lastname: Colegate
authors.forename: Franklin
authors.initials: F
authors.lastname: Riet-Correa
mesh_terms: D000818:Animals; D001938:Brazil; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000662:veterinary*; D029864:Crotalaria / Q000506:poisoning*; D004196:Disease Outbreaks / Q000662:veterinary*; D015511:Goat Diseases / Q000378:metabolism*; D006041:Goats; D006651:Histocytochemistry / Q000662:veterinary; D016686:Monocrotaline / Q000378:metabolism* / Q000506:poisoning; D012639:Seeds / Q000506:poisoning
chemical_list: D016686:Monocrotaline
keywords: Goats; liver necrosis; monocrotaline; pyrrolizidine alkaloids