title: Application of the amniotic membrane extract (AMX) for the persistent epithelial defect (PED) of the cornea.
abstract: A lot of pathological conditions could provoke damaging of the innervations of the cornea and lead to persistent epithelial defect (PED). AMX is lyophilized preparation of amniotic membrane (AM), which contains biological components and efficacy of AM for treatment of the corneal surface defects. In processing all the substances essential for biological effects of AM are preserved (growth factors, neutrophins, interleukins, receptors, fibronectins and different types of collagen). A patient can apply AMX as eye drops by himself in his home, thus avoiding surgical procedure. We presented two patients with PED; we treated them with eye drops of AMX, 2 drops every hour during day time. There was observed healing effect by reducing epithelial defect. Almost after a second day of application, and after 1-2 week period PED that persisted for weeks healed completely.
authors.affiliation: University of Zagreb, Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia. kordicr@net.hr
authors.forename: Rajko
authors.initials: R
authors.lastname: Kordić
authors.forename: Smiljka Popović
authors.initials: SP
authors.lastname: Suić
authors.forename: Sonja
authors.initials: S
authors.lastname: Jandroković
authors.forename: Miro
authors.initials: M
authors.lastname: Kalauz
authors.forename: Tomislav
authors.initials: T
authors.lastname: Kuzman
authors.forename: Ivan
authors.initials: I
authors.lastname: Skegro
authors.forename: Tomislav
authors.initials: T
authors.lastname: Jukić
mesh_terms: D000328:Adult; D000650:Amnion / Q000637:transplantation*; D003316:Corneal Diseases / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014020:Tissue Extracts / Q000627:therapeutic use*
chemical_list: D014020:Tissue Extracts