title: Primary multicentric anaplastic pleomorphic xanthoastrocytoma with atypical features.
abstract: Pleomorphic xanthoastrocytoma (PXA) is a rare tumor with good prognosis after surgery. Few cases of anaplastic PXA (either de novo or secondary to transformation of a recurrent low grade PXA) have been reported. Moreover, primary anaplastic PXA with dissemination at diagnosis has been described only in two patients, to our knowledge. We report the first case of primary multicentric anaplastic PXA and discuss its atypical features and the pertinent literature.
authors.affiliation: Institute of Neurosurgery, Catholic University, Largo Agostino Gemelli, 8, 00168 Rome, Italy. Electronic address: nicolamontanomd@yahoo.it.
authors.forename: Nicola
authors.initials: N
authors.lastname: Montano
authors.forename: Fabio
authors.initials: F
authors.lastname: Papacci
authors.forename: Beatrice
authors.initials: B
authors.lastname: Cioni
authors.forename: Simona
authors.initials: S
authors.lastname: Gaudino
authors.forename: Giuseppe Maria
authors.initials: GM
authors.lastname: Della Pepa
authors.forename: Giulio
authors.initials: G
authors.lastname: Conforti
authors.forename: Rina
authors.initials: R
authors.lastname: Di Bonaventura
authors.forename: Mariangela
authors.initials: M
authors.lastname: Novello
authors.forename: Libero
authors.initials: L
authors.lastname: Lauriola
authors.forename: Mario
authors.initials: M
authors.lastname: Meglio
mesh_terms: D001254:Astrocytoma / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D055815:Young Adult
keywords: Anaplastic pleomorphic xanthoastrocytoma; MRI; PXA; Prognosis; Radiotherapy; Surgery