title: Platinum compounds and sodium metabolism in children with diencephalic glioma.
abstract: In this brief report we have described eight children affected by optic pathway/hypothalamus gliomas and treated with carboplatin and/or cisplatin, which developed a derangement of sodium and water metabolism, due to diabetes insipidus (DI) or to syndrome of inappropriate antidiuretic hormone secretion (SIADH) after surgical resection. In four out of these eight patients the treatment with platinum compounds produced prolonged haematological toxicity and in five out of them it caused neurosensorial bilateral hypoacusia. In addition cisplatin worsened electrolytes disturbances. Hence children with DI or SIADH should be carefully monitored before, during and after the treatment with platinum compounds.
authors.affiliation: Division of Paediatric Oncology, Pol. A. Gemelli, Catholic University of Rome, Largo A. Gemelli, 00168, Rome, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Puma
authors.forename: A
authors.initials: A
authors.lastname: Ruggiero
authors.forename: M
authors.initials: M
authors.lastname: Scalzone
authors.forename: P
authors.initials: P
authors.lastname: Coccia
authors.forename: S
authors.initials: S
authors.lastname: Triarico
authors.forename: G
authors.initials: G
authors.lastname: Trombatore
authors.forename: S
authors.initials: S
authors.lastname: Mastrangelo
authors.forename: R
authors.initials: R
authors.lastname: Riccardi
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D016190:Carboplatin / Q000008:administration & dosage; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003919:Diabetes Insipidus / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000188:drug therapy / Q000378:metabolism; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D007223:Infant; D008297:Male; D019635:Neurosurgical Procedures / Q000009:adverse effects; D019574:Optic Nerve Neoplasms / Q000188:drug therapy / Q000378:metabolism; D011379:Prognosis; D012964:Sodium / Q000378:metabolism*; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced*
chemical_list: D012964:Sodium; D016190:Carboplatin; D002945:Cisplatin