title: [Prevalence of anosognosia in Alzheimer's disease].
abstract: OBJECTIVE
  Anosognosia is a disorder that affects the clinical presentation of Alzheimer's disease (AD), increasing in frequency with the evolution of AD. The objective was to determine the prevalence of anosognosia and analyze the associated factors and predictors.
  
  
  METHODS
  Multicenter transversal and observational study of 345 AD patients. Anosognosia was assessed by Anosognosia Questionnaire-Dementia and the evolutionary stage with the Global Deterioration Scale (GDS). Tests used were Mini-Mental State Examination, Disability Assessment for Dementia and Neuropsychiatric Inventory to assess cognition, functional status and neuropsychiatric symptoms, respectively. We adjusted linear regression models to determine the associated variables and binary logistic regression (RLog) to identify predictors of anosognosia.
  
  
  RESULTS
  The overall prevalence of anosognosia was 46.7% (95% confidence interval [95% CI] 41.3 to 52.1). The prevalence in stages was 28.4% (GDS 4), 64.6% (GDS 5) and 91.4% (GDS 6). The RLog identified as predictors older age (odds ratio [OR] 1.04; 95% CI 1.01-1.09), lower functional capacity (OR 0.96; 95% CI 0.93-0.98), lower cognitive level (OR 0.9; 95% CI 0.88-0.99), and greater apathy (OR 1.1; 95% CI 1.03-1.18), disinhibition (OR 1.2; 95% CI 1.09-1.50), irritability (OR 1.1; 95% CI 1.09-1.50) and motor disorders (OR 1.2; 95% CI 1.09-1.50).
  
  
  CONCLUSIONS
  Anosognosia increases with further deterioration. In patients with a mild impairment, predictor variables were apathy, disinhibition and motor disorders.
authors.affiliation: Unidad de Investigación, Institut d'Assistència Sanitària, Salt, Girona, España.
authors.forename: Oriol
authors.initials: O
authors.lastname: Turró-Garriga
authors.affiliation: Facultad de Psicología, Universitat de Barcelona, Barcelona, España. Electronic address: jllconde@ub.edu.
authors.forename: Josep Lluís
authors.initials: JL
authors.lastname: Conde-Sala
authors.affiliation: Unidad Funcional de Demencias, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: Ramón
authors.initials: R
authors.lastname: Reñé-Ramírez
authors.affiliation: Unidad de Investigación, Institut d'Assistència Sanitària, Salt, Girona, España; Unidad de Valoración de la Memoria y las Demencias, Hospital Santa Caterina, Institut d'Assistència Sanitària, Salt, Girona, España.
authors.forename: Secundino
authors.initials: S
authors.lastname: López-Pousa
authors.affiliation: Unidad Funcional de Demencias, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: Jordi
authors.initials: J
authors.lastname: Gascón-Bayarri
authors.affiliation: Unidad de Investigación, Institut d'Assistència Sanitària, Salt, Girona, España; Departamento de Psicología, Universitat de Girona, Girona, España.
authors.forename: Josep
authors.initials: J
authors.lastname: Garre-Olmo
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000377:Agnosia / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D000544:Alzheimer Disease / Q000150:complications / Q000523:psychology*; D057565:Apathy; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology / Q000209:etiology; D018450:Disease Progression; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D015995:Prevalence; D012649:Self Concept; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires
keywords: Alzheimer's disease; Anosognosia; Enfermedad de Alzheimer; Estudio multicéntrico; Multicenter study; Prevalence; Prevalencia