title: Algal lectins as promising biomolecules for biomedical research.
abstract: Lectins are natural bioactive ubiquitous proteins or glycoproteins of non-immune response that bind reversibly to glycans of glycoproteins, glycolipids and polysaccharides possessing at least one non-catalytic domain causing agglutination. Some of them consist of several carbohydrate-binding domains which endow them with the properties of cell agglutination or precipitation of glycoconjugates. Lectins are rampant in nature from plants, animals and microorganisms. Among microorganisms, algae are the potent source of lectins with unique properties specifically from red algae. The demand of peculiar and neoteric biologically active substances has intensified the developments on isolation and biomedical applications of new algal lectins. Comprehensively, algal lectins are used in biomedical research for antiviral, antinociceptive, anti-inflammatory, anti-tumor activities, etc. and in pharmaceutics for the fabrication of cost-effective protein expression systems and nutraceutics. In this review, an attempt has been made to collate the information on various biomedical applications of algal lectins.
authors.affiliation: Carbohydrate and Protein Biotechnology Laboratory, Department of Biotechnology, Punjabi University , Patiala, Punjab , India and.
authors.forename: Ram Sarup
authors.initials: RS
authors.lastname: Singh
authors.forename: Shivani Rani
authors.initials: SR
authors.lastname: Thakur
authors.forename: Parveen
authors.initials: P
authors.lastname: Bansal
mesh_terms: D000700:Analgesics; D000818:Animals; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D000460:Chlorophyta; D000458:Cyanobacteria; D004912:Erythrocytes; D006023:Glycoproteins; D006384:Hemagglutination; D006801:Humans; D037121:Plant Lectins; D000461:Rhodophyta
chemical_list: D000700:Analgesics; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D006023:Glycoproteins; D037121:Plant Lectins
keywords: Anti-HIV; antinociceptive; biomedical applications; cytokines; glycoproteins