title: Microwave-assisted surface modification of metallocene polyethylene for improving blood compatibility.
abstract: A wide number of polymers are being used for various medical applications. In this work, microwave-assisted surface modification of metallocene polyethylene (mPE) was studied. FTIR analysis showed no significant changes in the chemical groups after treatment. Contact angle analysis revealed a decrease in contact angle of the treated samples insinuating increasing hydrophilicity and better biocompatibility. Qualitative analysis of treated samples using scanning electron microscope (SEM) depicted increasing surface roughness and holes formation further corroborating the results. Coagulation assays performed for estimating prothrombin time (PT) and activated partial thromboplastin time (APTT) showed an increase in the clotting time which further confirmed the improved blood compatibility of the microwave-treated surfaces. Further, the extent of hemolysis in the treated sample was lower than the untreated one. Hence, microwave-assisted surface modification of mPE resulted in enhanced blood compatibility. Improved blood compatibility of mPE may be exploited for fabrication of artificial vascular prostheses, implants, and various blood contacting devices.
authors.affiliation: Department of Research and Development, PSNA College of Engineering and Technology, Kothandaraman Nagar, Dindigul, Tamil Nadu 624 622, India.
authors.forename: Hemanth
authors.initials: H
authors.lastname: Mohandas
authors.forename: Gunalan
authors.initials: G
authors.lastname: Sivakumar
authors.forename: Palaniappan
authors.initials: P
authors.lastname: Kasi
authors.forename: Saravana Kumar
authors.initials: SK
authors.lastname: Jaganathan
authors.forename: Eko
authors.initials: E
authors.lastname: Supriyanto
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001777:Blood Coagulation; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008872:Microwaves; D009942:Organometallic Compounds / Q000737:chemistry*; D010314:Partial Thromboplastin Time; D020959:Polyethylene / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D009942:Organometallic Compounds; C013108:metallocene; D020959:Polyethylene