title: A meta-analysis of endoscopic stenting as bridge to surgery versus emergency surgery for left-sided colorectal cancer obstruction.
abstract: The best approach to resolve colonic obstruction in patients with left-sided colon cancer is not established. In this meta-analysis the efficacy of stenting as bridge-to-surgery was compared to emergency surgery for the management of left-sided colonic obstruction. Fourteen studies (randomized and non controlled studies) were identified, including 405 patients in the stent group and 471 in the emergency group. The difference between proportions was evaluated as effect size (ESi). There was large heterogeneity among the studies. Stenting offered advantages over emergency surgery in terms of increase in primary anastomosis (ES=25.1%, p<0.001), successful primary anastomosis (ES=23.7%, p<0.001), reduction of stoma creation (ES=-27.1%, p=0.03), infections (ES=-7.9%, p=0.006) and other morbidities (ES=-13.4%, p<0.001). The interventions were similar in regards to length of hospitalization, preoperative mortality and long-term survival.
authors.affiliation: Unit of Digestive Endoscopy, IRCCS National Cancer Center Giovanni Paolo II, Bari, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: De Ceglie
authors.forename: Rosa
authors.initials: R
authors.lastname: Filiberti
authors.forename: Todd H
authors.initials: TH
authors.lastname: Baron
authors.forename: Marcello
authors.initials: M
authors.lastname: Ceppi
authors.forename: Massimo
authors.initials: M
authors.lastname: Conio
mesh_terms: D044683:Colon, Descending / Q000473:pathology*; D012809:Colon, Sigmoid / Q000473:pathology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D006801:Humans; D007415:Intestinal Obstruction / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications; D012007:Rectum / Q000473:pathology*; D015607:Stents; D016896:Treatment Outcome
keywords: Bridge to surgery; Colorectal cancer; Emergency surgery; Obstruction; SEMS; Stent