title: A highly efficient colorimetric immunoassay using a nanocomposite entrapping magnetic and platinum nanoparticles in ordered mesoporous carbon.
abstract: Nanocomposite to achieve ultrafast immunoassay: a new synergistically integrated nanocomposite consisting of magnetic and platinum nanoparticles, simultaneously entrapped in mesoporous carbon, is developed as a promising enzyme mimetic candidate to achieve ultrafast colorimetric immunoassays. Using new assay system, clinically important target molecules, such as human epidermal growth factor receptor 2 (HER2) and diarrhea-causing rotavirus, can be detected in only 3 min at room temperature with high specificity and sensitivity.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors.forename: Moon Il
authors.initials: MI
authors.lastname: Kim
authors.forename: Youngjin
authors.initials: Y
authors.lastname: Ye
authors.forename: Min-Ah
authors.initials: MA
authors.lastname: Woo
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Lee
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Park
mesh_terms: D000906:Antibodies / Q000276:immunology; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D002244:Carbon / Q000737:chemistry; D003124:Colorimetry; D005260:Female; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation / Q000379:methods*; D061986:MCF-7 Cells; D058185:Magnetite Nanoparticles / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry; D016062:Porosity; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis* / Q000276:immunology; D012401:Rotavirus / Q000276:immunology / Q000302:isolation & purification*; D013696:Temperature; D013997:Time Factors
chemical_list: D000906:Antibodies; D001672:Biocompatible Materials; D002244:Carbon; D052203:Ferrosoferric Oxide; D058185:Magnetite Nanoparticles; D010984:Platinum; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human
keywords: enzyme mimetics; immunoassays; magnetic nanoparticles; mesoporous materials; nanocomposite