title: Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration.
abstract: Nanotechnology is a vigorous research area and one of its important applications is in biomedical sciences. Among biomedical applications, targeted drug delivery is one of the most extensively studied subjects. Nanostructured particles and scaffolds have been widely studied for increasing treatment efficacy and specificity of present treatment approaches. Similarly, this technique has been used for treating bone diseases including bone regeneration. In this review, we have summarized and highlighted the recent advancement of nanostructured particles and scaffolds for the treatment of cancer bone metastasis, osteosarcoma, bone infections and inflammatory diseases, osteoarthritis, as well as for bone regeneration. Nanoparticles used to deliver deoxyribonucleic acid and ribonucleic acid molecules to specific bone sites for gene therapies are also included. The investigation of the implications of nanoparticles in bone diseases have just begun, and has already shown some promising potential. Further studies have to be conducted, aimed specifically at assessing targeted delivery and bioactive scaffolds to further improve their efficacy before they can be used clinically.
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
authors.forename: Wenyi
authors.initials: W
authors.lastname: Gu
authors.forename: Chengtie
authors.initials: C
authors.lastname: Wu
authors.forename: Jiezhong
authors.initials: J
authors.lastname: Chen
authors.forename: Yin
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000188:drug therapy*; D001861:Bone Regeneration; D016503:Drug Delivery Systems; D006801:Humans; D036103:Nanotechnology; D023822:Tissue Engineering
keywords: bone diseases; bone regeneration; cancer bone metastasis; nanoparticles; nanostructured scaffold; target drug delivery