title: Hydrogel blends with adjustable properties as patches for transdermal delivery.
abstract: The effect of different preparation parameters were analyzed with respect to the rheological and pharmaceutical characteristics of hydrogel blend patches, as transdermal delivery formulation. Mixtures of pectin and gelatin were employed for the production of patches, with adjustable properties, following a two-step gelation procedure. The first gelation, a thermal one, is trigged by the presence of gelatin, whereas, the second gelation, an ionic one, is due to the formation of the typical egg box structure of pectin. In particular, the patch structural properties were assessed by oscillation stress sweep measurements which provided information concerning their viscolelastic properties. In addition, different modalities for drug loading were analyzed with respect to drug homogeneous distribution; testosterone was employed as model drug for transdermal administration. Finally, the performances of the produced transdermal patches were studied, in term of reproducibility and reliability, by determination of in vitro drug release profiles.
authors.affiliation: Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Mazzitelli
authors.forename: Cinzia
authors.initials: C
authors.lastname: Pagano
authors.forename: Danilo
authors.initials: D
authors.lastname: Giusepponi
authors.forename: Claudio
authors.initials: C
authors.lastname: Nastruzzi
authors.forename: Luana
authors.initials: L
authors.lastname: Perioli
mesh_terms: D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004548:Elasticity; D005780:Gelatin / Q000737:chemistry*; D020100:Hydrogels; D007700:Kinetics; D008962:Models, Theoretical; D009991:Oscillometry; D010368:Pectins / Q000737:chemistry*; D012212:Rheology; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D013739:Testosterone / Q000008:administration & dosage / Q000737:chemistry*; D057968:Transdermal Patch; D014783:Viscosity
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D013739:Testosterone; D010368:Pectins; D005780:Gelatin
keywords: Gelatin; Hydrogels; Pectin; Transdermal delivery formulation