title: Novel polypropylene biocomposites reinforced with carbon nanotubes and hydroxyapatite nanorods for bone replacements.
abstract: Multi-walled carbon nanotubes (MWNTs) of 0.1 and 0.3 wt.% and hydoxyapatite nanorods (nHAs) of 8-20 wt.% were incorporated into polypropylene (PP) to form biocomposites using melt-compounding and injection molding techniques. The structural, mechanical, thermal and in vitro cell responses of the PP/MWNT-nHA hybrids were investigated. Tensile and impact tests demonstrated that the MWNT additions are beneficial in enhancing the stiffness, tensile strength and impact toughness of the PP/nHA nanocomposites. According to thermal analysis, the nHA and MWNT fillers were found to be very effective to improve dimensional and thermal stability of PP. The results of osteoblast cell cultivation and dimethyl thiazolyl diphenyl tetrazolium (MTT) tests showed that the PP/MWNT-nHA nanocomposites are biocompatible. Such novel PP/MWNT-nHA hybrids are considered to be potential biomaterials for making orthopedic bone implants.
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong.
authors.forename: Cheng Zhu
authors.initials: CZ
authors.lastname: Liao
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.forename: Hoi Man
authors.initials: HM
authors.lastname: Wong
authors.forename: Wing Yin
authors.initials: WY
authors.lastname: Tong
authors.forename: Kelvin Wai Kwok
authors.initials: KW
authors.lastname: Yeung
authors.forename: Sie Chin
authors.initials: SC
authors.lastname: Tjong
mesh_terms: D001672:Biocompatible Materials / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects*; D002152:Calorimetry, Differential Scanning; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003460:Crystallization; D017886:Durapatite / Q000494:pharmacology*; D055119:Elastic Modulus / Q000187:drug effects; D006801:Humans; D053761:Nanocomposites / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology / Q000648:ultrastructure; D011126:Polypropylenes / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013718:Tensile Strength / Q000187:drug effects; D013818:Thermogravimetry; D023822:Tissue Engineering; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D011126:Polypropylenes; D017886:Durapatite
keywords: Biocompatibility; Carbon nanotube; Hydroxyapatite; Nanocomposite; Osteoblast; Polypropylene