title: [Efficacy of radiotherapy for adult patients with Langerhans cell histiocytosis].
abstract: OBJECTIVE
  To analyze efficacy of radiotherapy for adult patients with Langerhans cell histiocytosis (LCH).
  
  
  METHODS
  Clinical features and efficacy of radiotherapy for biopsy-proven adult patient with LCH from January 2000 to October 2012 in our hospital were retrospectively analyzed.
  
  
  RESULTS
  Seventeen (11 male and 6 female) adult LCH patients with a mean age of 31 (18-56) years old were treated by irradiation, all patients presented as single-system disease. The mean duration from diagnosis to irradiation was 8.3 (0-108) months. Although 12 of 17 patients (70.6%) had short-term response to radiotherapy, all patients but one (94.1%) progressed during long-term follow-up, the mean progression-free survival (PFS) was 14 (0-131) months. Of the progressed patients, one relapsed in situ, the remaining 15 patients progressed outside the irradiated region. Thirteen patients (76.5%) eventually progressed to multisystem disease.
  
  
  CONCLUSIONS
  Though radiotherapy for LCH in adults produced a high short-term response up to 70.6%, most of patients eventually progressed in situ or outside the irradiation region during long-term follow-up.
authors.affiliation: Department of Hematology, PUMC Hospital, CAMS & PUMC, Beijing 100730, China.
authors.forename: Ming-hui
authors.initials: MH
authors.lastname: Duan
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Tie-nan
authors.initials: TN
authors.lastname: Zhu
authors.forename: Jun-ling
authors.initials: JL
authors.lastname: Zhuang
authors.forename: Dao-bin
authors.initials: DB
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult