title: Structural and biocompatible characterization of TiC/a:C nanocomposite thin films.
abstract: In this work, sputtered TiC/amorphous C thin films have been developed in order to be applied as potential barrier coating for interfering of Ti ions from pure Ti or Ti alloy implants. Our experiments were based on magnetron sputtering method, because the vacuum deposition provides great flexibility for manipulating material chemistry and structure, leading to films and coatings with special properties. The films have been deposited on silicon (001) substrates with 300 nm thick oxidized silicon sublayer at 200 °C deposition temperature as model substrate. Transmission electron microscopy has been used for structural investigations. Thin films consisted of ~20 nm TiC columnar crystals embedded by 5 nm thin amorphous carbon matrix. MG63 osteoblast cells have been applied for in vitro study of TiC nanocomposites. The cell culture tests give strong evidence of thin films biocompatibility.
authors.affiliation: Institute for Technical Physics and Materials Science, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Konkoly-Thege M.út 29-33, 1121 Budapest, Hungary. balazsi.katalin@ttk.mta.hu
authors.forename: K
authors.initials: K
authors.lastname: Balázsi
authors.forename: M
authors.initials: M
authors.lastname: Vandrovcová
authors.forename: L
authors.initials: L
authors.lastname: Bačáková
authors.forename: Cs
authors.initials: C
authors.lastname: Balázsi
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D002244:Carbon / Q000737:chemistry* / Q000494:pharmacology*; D002452:Cell Count; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D015675:Osteocalcin / Q000378:metabolism; D013052:Spectrometry, X-Ray Emission; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology*; D016596:Vinculin / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D016023:Integrins; D015675:Osteocalcin; C096521:titanium carbide; D016596:Vinculin; D002244:Carbon; D014025:Titanium
keywords: Biocompatibility; MG63; Nanocomposite; Osteoblast; TEM; TiC