title: Dimensions in cell migration.
abstract: The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depends profoundly on the dimensionality of the extracellular matrix (ECM). Here we review a number of evolving concepts revealed when cell migration is examined in different dimensions.
authors.affiliation: Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, United States. adoyle@mail.nih.gov
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Doyle
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Petrie
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Kutys
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Yamada
mesh_terms: D000818:Animals; D002465:Cell Movement; D002468:Cell Physiological Phenomena; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015398:Signal Transduction