title: Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice.
abstract: OBJECTIVE
  To investigate the effect of endogenous n-3 polyunsaturated fatty acids (PUFAs) on bone marrow adipogenesis under osteoporosis conditions.
  
  
  METHODS
  A mouse osteoporosis model overexpressing the FAT1 gene from Caenorhabditis elegans and converting n-6 PUFAs to n-3 PUFAs endogenously was used.
  
  
  RESULTS
  The mice presented significantly lower bone marrow adiposity (adipocyte volume/tissue volume, mean adipocyte number) but increased the bone parameters (bone mineral density, bone mineral content, bone volume/total volume) in the distal femoral metaphysis.
  
  
  CONCLUSIONS
  Endogenous n-3 PUFAs protect bone marrow adipogenesis, which provides a novel drug target.
authors.affiliation: Department of Orthopaedic, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Tian-yu
authors.initials: TY
authors.lastname: Chen
authors.forename: Zhong-min
authors.initials: ZM
authors.lastname: Zhang
authors.forename: Xiao-chen
authors.initials: XC
authors.lastname: Zheng
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Min-jun
authors.initials: MJ
authors.lastname: Huang
authors.forename: Si
authors.initials: S
authors.lastname: Qin
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Ping-lin
authors.initials: PL
authors.lastname: Lai
authors.forename: Cheng-liang
authors.initials: CL
authors.lastname: Yang
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Yi-fan
authors.initials: YF
authors.lastname: Dai
authors.forename: Da-di
authors.initials: DD
authors.lastname: Jin
authors.forename: Xiao-chun
authors.initials: XC
authors.lastname: Bai
mesh_terms: D050156:Adipogenesis; D050154:Adiposity; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D015820:Cadherins / Q000235:genetics / Q000502:physiology*; D050659:Core Binding Factor Alpha 1 Subunit / Q000032:analysis; D015525:Fatty Acids, Omega-3 / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010024:Osteoporosis / Q000517:prevention & control*; D010052:Ovariectomy; D047495:PPAR gamma / Q000032:analysis
chemical_list: D015820:Cadherins; D050659:Core Binding Factor Alpha 1 Subunit; D015525:Fatty Acids, Omega-3; D047495:PPAR gamma; C493716:Runx2 protein, mouse; C502406:fat1 protein, mouse
keywords: adipogenesis; antiosteoporosis; bone marrow; n-3 PUFAs