title: Impact of hypertension on vascular remodeling in patients with psoriatic arthritis.
abstract: We studied the impact of hypertension along with traditional and new cardiovascular risk factors on the structural and functional properties of arteries in psoriatic arthritis (PsA) patients. We examined 42 PsA subjects (aged 51±9 years) stratified according to hypertensive status (19 normotensive, PsA-NT and 23 hypertensives, PsA-HT). Thirty-eight normotensive subjects (C-NT) and 23 hypertensives (C-HT) comparable by age and sex served as controls. Mean carotid intima-media thickness (mean-IMT) and mean of the maximum IMT (M-Max) were evaluated by ultrasound in carotid artery segment bilaterally. Post-occlusion flow-mediated dilation (FMD) of the brachial artery was evaluated by ultrasonography. These parameters were correlated with risk factors, markers of inflammation and disease activity. Values of mean-IMT were higher in both groups of PsA patients compared with C-NT (0.68 mm in PsA-NT and 0.75 mm in PsA-HT versus 0.61 mm in C-NT). PsA-HT displayed higher M-Max (0.95 mm) versus both C-HT (0.71 mm) and PsA-NT (0.79 mm). FMD was impaired in PsA subjects compared with C-NT (5.7% in PsA-NT and 6.0% PsA-HT versus 9.3% in C-NT), whereas there was no difference among PsA-HT, PsA-NT, and C-HT groups. Values of carotid IMT were directly related to tumor necrosis factor (TNF)-α, osteoprotegerin (OPG), blood pressure and lipid profile levels. FMD showed an inverse relationship with TNF-α and blood pressure, but no correlation with lipids. In conclusion, PsA per se implies a pro-atherogenic remodeling, which is enhanced by the hypertensive status. TNF-α and OPG may have an independent role in the development of such vascular damage.
authors.affiliation: Clinica Medica 4, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Puato
authors.affiliation: Reumatology Unit, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ramonda
authors.affiliation: Reumatology Unit, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Doria
authors.affiliation: Medicina Interna I, Treviso, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rattazzi
authors.affiliation: Clinica Medica 4, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Faggin
authors.affiliation: Clinica Medica 4, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Balbi
authors.affiliation: Clinica Medica 4, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zanon
authors.affiliation: Clinica Medica 4, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zanardo
authors.affiliation: Clinica Medica 4, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Tirrito
authors.affiliation: Reumatology Unit, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Lorenzin
authors.affiliation: Reumatology Unit, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Modesti
authors.affiliation: Department of Laboratory Medicine, University of Padova, Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Plebani
authors.affiliation: Department of Laboratory Medicine, University of Padova, Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zaninotto
authors.affiliation: Reumatology Unit, Department of Medicine DMED, University of Padova, Padova, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Punzi
authors.affiliation: Medicina Interna I, Treviso, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Pauletto
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood; D011237:Predictive Value of Tests; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human; D014409:Tumor Necrosis Factor-alpha