title: The angiotensin-converting enzyme (ACE) I/D polymorphism in Parkinson's disease.
abstract: OBJECTIVE
  The angiotensin-converting enzyme (ACE) may be involved in the pathogenesis of Parkinson's disease (PD). There have been several studies investigating the association between ACE gene I/D polymorphism and PD risk, but they reported inconsistent findings. We performed a meta-analysis to investigate the association between ACE gene I/D polymorphism and PD risk.
  
  
  METHODS
  Published literature from PubMed and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using random- or fixed-effects models based on between-study heterogeneity.
  
  
  RESULTS
  A total of five studies including 606 cases and 708 controls were finally included in the meta-analysis. Meta-analysis showed that there was no obvious association between ACE gene I/D polymorphism and PD risk under the homogeneous co-dominant model (OR = 1.14, 95% CI = 0.71-1.82), heterogeneous co-dominant model (OR = 0.92, 95% CI = 0.70-1.22), dominant model (OR = 0.99, 95% CI = 0.76-1.28) or recessive model (OR = 1.07, 95% CI = 0.83-1.37).
  
  
  CONCLUSIONS
  The meta-analysis suggests that there is no evidence for the association between ACE gene I/D polymorphism and PD risk.
authors.affiliation: Department of Neurosurgery, The Fourth People's Hospital of Jinan, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Su
authors.affiliation: Department of Neurosurgery, The Fourth People's Hospital of Jinan, China.
authors.forename: Hengli
authors.initials: H
authors.lastname: Dou
authors.affiliation: Department of Neurosurgery, The Fourth People's Hospital of Jinan, China.
authors.forename: Limei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, The Fourth People's Hospital of Jinan, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Fourth People's Hospital of Jinan, China.
authors.forename: Guiyang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The Fourth People's Hospital of Jinan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, The Fourth People's Hospital of Jinan, China bopengjn@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Peng
mesh_terms: D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D008957:Models, Genetic; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; Parkinson’s disease; meta-analysis; polymorphism