title: Urinary tract infection.
abstract: The urinary tract is a common source for life-threatening infections. Most patients with sepsis or septic shock from a urinary source have complicated urinary tract infection. This article explains the epidemiology, risk factors, and treatment. Effective management, appropriate collection of microbiology specimens, prompt initiation of antimicrobial therapy, source control, and supportive therapy are described.
authors.affiliation: Department of Internal Medicine, Health Sciences Centre, University of Manitoba, Room GG443, 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada. lnicolle@hsc.mb.ca
authors.forename: Lindsay E
authors.initials: LE
authors.lastname: Nicolle
mesh_terms: D000208:Acute Disease; D000617:Aminoglycosides / Q000627:therapeutic use*; D000666:Amphotericin B / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002408:Catheters, Indwelling / Q000009:adverse effects / Q000382:microbiology; D017714:Community-Acquired Infections; D003428:Cross Infection; D003840:Deoxycholic Acid / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D012772:Shock, Septic / Q000150:complications* / Q000382:microbiology; D014551:Urinary Tract / Q000002:abnormalities* / Q000382:microbiology; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000617:Aminoglycosides; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D004338:Drug Combinations; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D015725:Fluconazole
keywords: Bacteremia; Complicated urinary infection; Pyelonephritis; Urosepsis