title: Management of prelabour rupture of membranes (PROM) at term.
abstract: Over a 20-month period we identified several cases of neonatal pneumonia associated with prelabour rupture of membranes (PROM) at term. PROM complicates 8%-10% of all pregnancies, yet 60% of cases occur at term. Ascending infection is a contributing factor and the incidence of chorioamnionitis in these patients is relatively high, especially with prolonged membrane rupture. The signs and symptoms NICE recommends patients look out for are not always present as the majority of infections are subclinical, yet associated maternal and neonatal morbidity of chorioamnionitis is potentially devastating. A survey of maternity units in the West Midlands reveals significant variance in management of these cases. Given the lack of consensus and clear evidence on optimal management of PROM at term, we believe early detection of developing infections could be enhanced by using a combination of investigations (at presentation, 12 and 24 h), as well as current advice to self-monitor temperature and vaginal loss.
authors.forename: Abdul Qader Tahir
authors.initials: AQ
authors.lastname: Ismail
authors.forename: Soma
authors.initials: S
authors.lastname: Lahiri
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001424:Bacterial Infections / Q000150:complications / Q000517:prevention & control; D002821:Chorioamnionitis; D019317:Evidence-Based Medicine; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology / Q000628:therapy*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced; D011014:Pneumonia / Q000151:congenital* / Q000453:epidemiology / Q000209:etiology*; D017410:Practice Guidelines as Topic; D011247:Pregnancy
chemical_list: D000900:Anti-Bacterial Agents