title: First and second trimester biochemical markers in familial mediterranean fever.
abstract: OBJECTIVE
  Our aim was to investigate whether the maternal serum concentrations of first and second trimester serum analytes are altered in familial Mediterranean fever (FMF) pregnancies.
  
  
  METHODS
  The screening tests were compared in a series of 16 serum samples from FMF pregnancies and in a cohort of 48 pregnant women with normal pregnancy. Serum samples were obtained between 11 and 13 weeks; 16 and 18 weeks gestation.
  
  
  RESULTS
  Serum pregnancy-associated plasma protein-A (PAPP-A) levels, expressed as multiples of the median (0.9 ± 0.45 MoM) in the control group, were significantly higher than FMF patients (0.6 ± 0.3 MoM) (p = 0.027). Analyses of alpha-fetoprotein, human chorionic gonadotropin and oestriol levels showed no significant differences between FMF and normal pregnancies.
  
  
  CONCLUSIONS
  Our study revealed that low levels of PAPP-A are associated with FMF.
authors.affiliation: Gynecology and Obstetrics Department, Zekai Tahir Burak Woman's Health Education and Research Hospital, Ankara, Turkey. fcapar@yahoo.com
authors.forename: F
authors.initials: F
authors.lastname: Turkcapar
authors.forename: Y
authors.initials: Y
authors.lastname: Engin-Üstün
authors.forename: O Y
authors.initials: OY
authors.lastname: Simsek
authors.forename: R
authors.initials: R
authors.lastname: Deveer
authors.forename: N
authors.initials: N
authors.lastname: Danisman
authors.forename: U
authors.initials: U
authors.lastname: Dilmen
authors.forename: L
authors.initials: L
authors.lastname: Mollamahmutoglu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D015331:Cohort Studies; D010505:Familial Mediterranean Fever / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D011261:Pregnancy Trimester, First / Q000502:physiology*; D011262:Pregnancy Trimester, Second / Q000502:physiology*; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis
chemical_list: D015415:Biomarkers; D011266:Pregnancy-Associated Plasma Protein-A