title: Adalimumab (Humira) induced acute lung injury.
abstract: METHODS
  Male, 78.
  
  
  METHODS
  Acute lung injury due to Adalimumab.
  
  
  METHODS
  -
  
  
  METHODS
  Adalimumab.
  
  
  METHODS
  Intubated and put on mechanical ventilation.
  
  
  METHODS
  Pulmonology.
  
  
  OBJECTIVE
  Unusual or unexpected effect of treatment.
  
  
  BACKGROUND
  Adalimumab is a recombinant human monoclonal antibody that blocks the effects of tumor necrosis factor-alpha. Adalimumab related acute lung injury is a rare form of acute respiratory distress syndrome of possible immune etiology that develops immediately after an infusion.
  
  
  METHODS
  We describe a 78 year old, male with no previous cardiac comorbidities, who developed acute lung injury (ALI) within one hour of administration of adalimumab. He was successfully treated with mechanical ventilatory support and adjuvant therapy.
  
  
  CONCLUSIONS
  TNFα antagonists are a part of a new and revolutionary treatment for severe and difficult-to-treat autoimmune and inflammatory diseases. This report emphasizes that this fatal complication may occur with use of this drug. Clinicians need to be aware of this condition as prompt recognition and supportive management can prevent unwanted morbidity and mortality.
authors.affiliation: Department of Internal Medicine, Bridgeport Hospital/Yale University Program, Bridgeport, CT, U.S.A.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Kohli
authors.forename: Karim
authors.initials: K
authors.lastname: Namek
keywords: Adalimumab; acute lung injury (ALI); respiratory distress