title: De novo aneurysms in long-term follow-up computed tomographic angiography of patients with clipped intracranial aneurysms.
abstract: OBJECTIVE
  This study was undertaken to evaluate de novo aneurysm formation in the long-term follow-up of patients with clipped aneurysms.
  
  
  METHODS
  Of 459 patients who underwent clipping of ruptured cerebral aneurysms at our institution between 1997 and 2008, 119 patients were available in good condition and agreed to undergo 64-detector row computed tomographic (CT) angiography. In addition, eight patients underwent CT angiography for new subarachnoid hemorrhage.
  
  
  RESULTS
  The mean ± standard deviation interval from surgery was 7.2 ± 2.3 years for CT angiography controlled patients. De novo aneurysms were detected in 5 of 119 (4.5%) patients and 4 of 8 patients with new subarachnoid hemorrhage. A history of multiple aneurysms was associated with de novo aneurysm formation (P < 0.001).
  
  
  CONCLUSIONS
  The risk of de novo aneurysm formation in patients with clipped aneurysms is significant in long-term follow-up. CT angiography can be used as a noninvasive method for detection of de novo aneurysms in these patients.
authors.affiliation: Department of Neurosurgery, Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: FNRC.AZ@hotmail.com.
authors.forename: Alireza
authors.initials: A
authors.lastname: Zali
authors.affiliation: Department of Neurosurgery, Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Reza Jalili
authors.initials: RJ
authors.lastname: Khoshnood
authors.affiliation: Department of Neuroscience, Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Zarghi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000601:surgery; D002533:Cerebral Angiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D012008:Recurrence; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging* / Q000601:surgery*; D013525:Surgical Instruments; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: CT angiography; Cerebral aneurysm; De novo aneurysm; Surgical clipping