title: Long-term results after treatment of periodontitis in patients with Papillon-Lefèvre syndrome: success and failure.
abstract: OBJECTIVE
  Retrospective evaluation of periodontal status in patients with Papillon-Lefèvre syndrome (PLS) observed for ≥10 years; identification of factors that may influence treatment outcome; and reporting of the outcome of dental implants in four PLS patients.
  
  
  METHODS
  All PLS patients currently registered at the Department of Periodontology, Goethe-University Frankfurt with a follow-up ≥10 years (13-33 years; mean 22 years) were recruited. Eight patients (aged 17-46 years) from five families (three pairs of siblings) were included.
  
  
  RESULTS
  After comprehensive periodontal therapy in eight PLS patients, teeth were retained in only two. In six patients, all teeth were extracted, almost entirely due to periodontal reasons. In four patients, teeth were prosthodontically restored with implants. Currently, three patients already show peri-implantitis.
  
  
  CONCLUSIONS
  In some PLS patients, periodontitis may be arrested by: combined mechanical and antibiotic periodontal treatment; extraction of severely diseased teeth; oral hygiene instructions; intensive maintenance therapy; and microbiological monitoring and treatment of the infection with Aggregatibacter actinomycetemcomitans. Implants in PLS patients who did not follow any maintenance programme have a high risk of peri-implantitis and implant loss. Treatment of PLS patients has always to be considered as high-risk cases.
authors.affiliation: Department of Periodontology, Center for Dental, Oral, and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany. nickles@med.uni-frankfurt.de
authors.forename: Katrin
authors.initials: K
authors.lastname: Nickles
authors.forename: Beate
authors.initials: B
authors.lastname: Schacher
authors.forename: Petra
authors.initials: P
authors.lastname: Ratka-Krüger
authors.forename: Mischa
authors.initials: M
authors.lastname: Krebs
authors.forename: Peter
authors.initials: P
authors.lastname: Eickholz
mesh_terms: D000293:Adolescent; D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D015921:Dental Implants; D019232:Dental Restoration Failure; D012534:Dental Scaling / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010214:Papillon-Lefevre Disease / Q000150:complications*; D057873:Peri-Implantitis / Q000209:etiology; D010512:Periodontal Index; D010518:Periodontitis / Q000150:complications / Q000628:therapy*; D012189:Retrospective Studies; D016745:Root Planing / Q000379:methods; D014081:Tooth Extraction; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D015921:Dental Implants
keywords: Aggregatibacter actinomycetemcomitans; Papillon-Lefèvre syndrome; dental implants; long-term results; peri-implantitis; periodontitis