title: More than meets the eye: conformational switching of a stacked dialkoxynaphthalene-naphthalenetetracarboxylic diimide (DAN-NDI) foldamer to an NDI-NDI fibril aggregate.
abstract: The thermally induced conformational switching of a stacked dialkxoynaphthalene-naphthalenetetracarboxylic diimide (DAN-NDI) amphiphilic foldamer to an NDI-NDI fibril aggregate is described. The aggregated fibril structures were explored by UV/Vis, circular dichroism (CD), atomic-force microscopy (AFM), and TEM techniques. Our findings indicate that the aromatic DAN-NDI interactions of the original foldamer undergoes transformation to a fibrillar assembly with aromatic NDI-NDI stacked interactions. These structural insights could help inform new molecular designs and increase our understanding of fibrillar assembly and aggregation process in aqueous solution.
authors.affiliation: Department of Chemistry & Biochemistry, The University of Austin at Texas, Welch Hall 2.204, 105 E. 24th Str. STOP A5300, Austin, TX 78712, USA.
authors.forename: Cameron
authors.initials: C
authors.lastname: Peebles
authors.forename: Rebecca
authors.initials: R
authors.lastname: Piland
authors.forename: Brent L
authors.initials: BL
authors.lastname: Iverson
mesh_terms: D007094:Imides / Q000737:chemistry*; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry*
chemical_list: D007094:Imides; D009281:Naphthalenes
keywords: aggregation; pi interactions; self-assembly; supramolecular chemistry; synthetic biology