title: Primary hyperparathyroidism with water clear cell content: the impact of histological diagnosis on clinical management and outcome.
abstract: Water clear cell hyperplasia (WCCH) and water clear cell adenomas (WCCA) of the parathyroid glands are rare causes of primary hyperparathyroidism. We report in this series one case of WCCH and two cases of WCCA representing 0.3% of patients with primary hyperparathyroidism presenting to our institution. Increased parathyroid cellular water content was responsible for relatively larger parathyroid gland sizes. However, this was not associated with higher biochemical markers or more severe clinical presentations. Histological distinction between WCCH and WCCA is difficult but important since patients with WCCH who have had a parathyroidectomy via a unilateral neck exploration may carry an increased risk of future disease recurrence.
authors.affiliation: University College London Hospital, 250 Euston Road, London NW1 2PG, UK. t.abdel-aziz@ucl.ac.uk
authors.forename: T
authors.initials: T
authors.lastname: Ezzat
authors.forename: G M
authors.initials: GM
authors.lastname: Maclean
authors.forename: R
authors.initials: R
authors.lastname: Parameswaran
authors.forename: B
authors.initials: B
authors.lastname: Phillips
authors.forename: V
authors.initials: V
authors.lastname: Komar
authors.forename: R
authors.initials: R
authors.lastname: Mihai
authors.forename: G
authors.initials: G
authors.lastname: Sadler
authors.forename: S
authors.initials: S
authors.lastname: Courtney
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000368:Aged; D001834:Body Water; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006965:Hyperplasia / Q000150:complications / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000473:pathology*; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome