title: Capsular bag opacification with a new accommodating intraocular lens.
abstract: OBJECTIVE
  To evaluate the biocompatibility and capsular bag opacification of an accommodating intraocular lens (IOL) containing large haptic elements that separate the anterior and posterior capsules.
  
  
  METHODS
  John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Bilateral phacoemulsification with IOL implantation was performed in 6 New Zealand rabbits. Each animal received a study (accommodating) IOL and a control (1-piece hydrophobic acrylic) IOL. Eyes were examined at the slitlamp from 1 day through 6 weeks postoperatively. The globes were then enucleated and evaluated grossly. Capsular bag opacification was scored from the posterior aspect (Miyake-Apple view). The eyes were then processed for complete histopathologic evaluation.
  
  
  RESULTS
  At 6 weeks, the mean posterior capsule opacification (PCO) clinical score was 0.5 ± 0.3 (SD) in the study group and 3.0 ± 0.9 in the control group (P=.001, 2-tail paired t test). Anterior capsule opacification was practically absent in the study group and mild in the control group. Miyake-Apple posterior view showed a mean central PCO score of 0 ± 0 in the study group and 3.0 ± 1.1 in the control group (P=.001), peripheral PCO score of 0.7 ± 0.4 and 3.5 ± 0.8 (P=.0006), respectively, and Soemmerring ring score of 2.3 ± 0.8 and 7.0 ± 2.8 (P=.01), respectively. Histopathology showed no signs of toxicity in any eye.
  
  
  CONCLUSIONS
  The study IOL maintained an expanded capsular bag secondary to the large size of the haptic elements, which appears to prevent capsular bag opacification.
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Floyd
authors.forename: Liliana
authors.initials: L
authors.lastname: Werner
authors.forename: Erica
authors.initials: E
authors.lastname: Liu
authors.forename: Shannon
authors.initials: S
authors.lastname: Stallings
authors.forename: Andrew
authors.initials: A
authors.lastname: Ollerton
authors.forename: Lisa
authors.initials: L
authors.lastname: Leishman
authors.forename: Zachary
authors.initials: Z
authors.lastname: Bodnar
authors.forename: Caleb
authors.initials: C
authors.lastname: Morris
authors.forename: Nick
authors.initials: N
authors.lastname: Mamalis
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D058442:Capsule Opacification / Q000517:prevention & control*; D004847:Epithelial Cells / Q000473:pathology; D005355:Fibrosis / Q000517:prevention & control; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008422:Materials Testing; D023421:Models, Animal; D018918:Phacoemulsification; D011183:Postoperative Complications; D011474:Prosthesis Design; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials