title: Aptamer-directed synthesis of multifunctional lanthanide-doped porous nanoprobes for targeted imaging and drug delivery.
abstract: Multifunctional lanthanide-doped porous nanoparticles are prepared via a facile one-step solvothermal route by employing aptamers as the biotemplate. The nanoparticles feature excellent aqueous dispersibility and biospecific properties and could work as effective nanoprobes for targeted imaging and drug delivery. With aptamer being in principle available for any kind of target, this synthetic strategy may open the door to a new generation of nanoprobes for bioapplications such as time-resolved biodetection, multimode bioimaging/biolabeling, and targeted cancer therapy.
authors.affiliation: Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625; Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Li
authors.forename: Enguo
authors.initials: E
authors.lastname: Ju
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D002460:Cell Line; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D061986:MCF-7 Cells; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009369:Neoplasms / Q000628:therapy; D009841:Oligonucleotides / Q000737:chemistry; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D003287:Contrast Media; D028581:Lanthanoid Series Elements; D009841:Oligonucleotides; D013778:Tetrazolium Salts; D013844:Thiazoles; D004247:DNA; C022616:thiazolyl blue
keywords: aptamers; drug delivery; lanthanides; nanoprobes; targeted imaging