title: Safety of ovarian preservation in young patients with early-stage endometrial cancer: a retrospective study and meta-analysis.
abstract: OBJECTIVE
  To evaluate the impact of ovarian preservation on overall survival in young women with early-stage endometrial cancer.
  
  
  METHODS
  Retrospective and meta-analysis.
  
  
  METHODS
  Two medical centers.
  
  
  METHODS
  A total of 203 patients diagnosed with endometrial cancer (≤45 years) from 2000 until 2010.
  
  
  METHODS
  Patients who underwent oophorectomy versus those whose ovaries were preserved.
  
  
  METHODS
  The overall survivals were compared. Independent factors that may affect the patients' survival were extracted and analyzed. A meta-analysis of the literature was carried out to further validate the findings.
  
  
  RESULTS
  Of 203 young patients, 169 patients (83.3%) underwent bilateral salpingo-oophorectomy, 20 patients had both ovaries preserved, and 14 patients had a single ovary preserved. Multivariate logistic regression identified intraoperative extrauterine disease as the most significant risk factor of ovarian involvement. A Kaplan-Meier curve and Cox proportional hazards models analyses found that ovarian preservation had no effect on overall survival. The findings were validated by meta-analysis.
  
  
  CONCLUSIONS
  Ovarian preservation has no statistically significant impact on the overall survival of young patients with early-stage endometrial cancer. The ovaries should be preserved in this specific population after a thorough preoperative evaluation and an extensive intraoperative exploration.
authors.affiliation: Department of Obstetrics and Gynaecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Sun
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Zongyuan
authors.initials: Z
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Jiang
authors.forename: Xingsheng
authors.initials: X
authors.lastname: Yang
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: Tao
authors.initials: T
authors.lastname: Zhu
authors.forename: Juncheng
authors.initials: J
authors.lastname: Wei
authors.forename: Danhui
authors.initials: D
authors.lastname: Weng
authors.forename: Ding
authors.initials: D
authors.lastname: Ma
authors.forename: Changyu
authors.initials: C
authors.lastname: Wang
authors.forename: Beihua
authors.initials: B
authors.lastname: Kong
mesh_terms: D000328:Adult; D000367:Age Factors; D018269:Carcinoma, Endometrioid / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments; D010052:Ovariectomy / Q000009:adverse effects*; D010053:Ovary / Q000601:surgery*; D061214:Patient Safety; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
keywords: Endometrial cancer; oophorectomy; survival