title: Oxygen tension level and human viral infections.
abstract: The role of oxygen tension level is a well-known phenomenon that has been studied in oncology and radiotherapy since about 60 years. Oxygen tension may inhibit or stimulate propagation of viruses in vitro as well as in vivo. In turn modulating oxygen metabolism may constitute a novel approach to treat viral infections as an adjuvant therapy. The major transcription factor which regulates oxygen tension level is hypoxia-inducible factor-1 alpha (HIF-1α). Down-regulating the expression of HIF-1α is a possible method in the treatment of chronic viral infection such as human immunodeficiency virus infection, chronic hepatitis B and C viral infections and Kaposi sarcoma in addition to classic chemotherapy. The aim of this review is to supply an updating concerning the influence of oxygen tension level in human viral infections and to evoke possible new therapeutic strategies regarding this environmental condition.
authors.affiliation: Centre des Innovations Thérapeutiques en Oncologie et Hématologie (CITOH), CHU Saint-Louis, Paris, France. frederic.morinet@sls.aphp.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Morinet
authors.forename: Luana
authors.initials: L
authors.lastname: Casetti
authors.forename: Jean-Hugues
authors.initials: JH
authors.lastname: François
authors.forename: Claude
authors.initials: C
authors.lastname: Capron
authors.forename: Sylvie
authors.initials: S
authors.lastname: Pillet
mesh_terms: D000998:Antiviral Agents / Q000378:metabolism*; D004358:Drug Therapy / Q000379:methods*; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D014777:Virus Diseases / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D010100:Oxygen
keywords: HIF-1 alpha inhibitor; Hypoxia; Hypoxia inducible factor 1 alpha; Oxygen tension level and viruses