title: Active ion transporters from readily accessible acyclic octapeptides containing 3-aminobenzoic acid and alanine.
abstract: Ion transporters have been developed from acyclic octapeptides comprising L/D alanine and m-aminobenzoic acid. These octapeptides transport cations up to 3 times faster than their cyclic analog through lipid vesicles. Preliminary CD, XRD and computational studies allude to a 6-9 Å wide tetrameric ion channel as the active ion transporter.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai - 600036, Tamil Nadu, India.
authors.forename: Bahiru P
authors.initials: BP
authors.lastname: Benke
authors.forename: Nandita
authors.initials: N
authors.lastname: Madhavan
mesh_terms: D000409:Alanine / Q000737:chemistry*; D002942:Circular Dichroism; D003500:Cyclization; D017136:Ion Transport; D008954:Models, Biological; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D062368:meta-Aminobenzoates / Q000737:chemistry*
chemical_list: D010455:Peptides; D062368:meta-Aminobenzoates; C044855:3-aminobenzoic acid; D000409:Alanine