title: Long-lasting antifouling coating from multi-armed polymer.
abstract: We describe a new antifouling surface coating, based on aggregation of a short amphiphilic four-armed PEG-dopamine polymer into particles and on surface binding by catechol chemistry. An unbroken and smooth polymeric coating layer with an average thickness of approximately 4 μm was formed on top of titanium oxide surfaces by a single step reaction. Coatings conferred excellent resistance to protein adhesion. Cell attachment was completely prevented for at least eight weeks, although the membranes themselves did not appear to be intrinsically cytotoxic. When linear PEG or four-armed PEG of higher molecular weight were used, the resulting coatings were inferior in thickness and in preventing protein adhesion. This coating method has potential applicability for biomedical devices susceptible to fouling after implantation.
authors.affiliation: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
authors.forename: Boaz
authors.initials: B
authors.lastname: Mizrahi
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Khoo
authors.forename: Homer H
authors.initials: HH
authors.lastname: Chiang
authors.forename: Katalina J
authors.initials: KJ
authors.lastname: Sher
authors.forename: Rose G
authors.initials: RG
authors.lastname: Feldman
authors.forename: Jung-Jae
authors.initials: JJ
authors.lastname: Lee
authors.forename: Silvia
authors.initials: S
authors.lastname: Irusta
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kohane
mesh_terms: D000818:Animals; D057219:Biofouling / Q000517:prevention & control*; D002396:Catechols / Q000737:chemistry; D002417:Cattle; D002470:Cell Survival; D004298:Dopamine / Q000138:chemical synthesis / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology; D051379:Mice; D015394:Molecular Structure; D008970:Molecular Weight; D041681:NIH 3T3 Cells; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D002396:Catechols; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D014025:Titanium; C034221:catechol; D004298:Dopamine