title: BRAF: a driver of the serrated pathway in colon cancer.
abstract: In this issue of Cancer Cell, Rad and colleagues report findings that underscore the importance of oncogenic BRAF mutation coupled with microsatellite instability, p16Ink4a inactivation, and p53 mutation in the serrated pathway of colon cancer development. These findings provide translational insights into potential therapeutic intervention for BRAF mutant colon cancers.
authors.affiliation: Division of Gastroenterology, Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, 952 BRB, 421 Curie Boulevard, Philadelphia, PA 19104, USA. anil2@mail.med.upenn.edu
authors.forename: Anil K
authors.initials: AK
authors.lastname: Rustgi
mesh_terms: D003110:Colonic Neoplasms / Q000209:etiology* / Q000235:genetics; D019942:Genes, p16; D016158:Genes, p53; D006801:Humans; D053842:Microsatellite Instability; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins / Q000235:genetics
chemical_list: C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins