title: AGT M235T variant is not associated with risk of cancer.
abstract: OBJECTIVE
  The angiotensinogen (AGT) gene has been considered to be implicated in the development of cancer. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of AGT M235T variant with cancer risk.
  
  
  METHODS
  Published literature from PubMed and Embase were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using a fixed- or random-effects model.
  
  
  RESULTS
  A total of seven articles including eight studies (3639 cancer cases and 6684 controls) for AGT M235T variant were included. The present meta-analysis showed that AGT M235T variant was marginally associated with cancer risk under dominant model (OR=1.12, 95% CI=1.02-1.24). However, the positive association was not stable after sensitivity analysis. Further subgroup analysis by cancer type did not suggest any association of AGT M235T variant with various cancers (all p>0.05).
  
  
  CONCLUSIONS
  The present meta-analysis demonstrated that AGT M235T variant was not associated with risk of all cancer or various cancers. Further well-designed studies with large sample size should be conducted to confirm or refute the non-significant association.
authors.affiliation: The First People's Hospital of Xiangshan County, Ningbo, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Lin
authors.affiliation: Medical school, Taizhou University, Taizhou, China.
authors.forename: Jiayu
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, Taizhou Municipal Hospital, Taizhou, China chibo_liu@163.com.
authors.forename: Chibo
authors.initials: C
authors.lastname: Liu
mesh_terms: D000808:Angiotensinogen / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
chemical_list: D000808:Angiotensinogen
keywords:     AGT gene; cancer; meta-analysis; renin–angiotensin system; variant