title: Decline in immature transitional B cells after hepatitis B vaccination in hepatitis B positive newborns.
abstract: Humoral immune responses are protective against hepatitis B virus (HBV) infection. We characterized B-cell phenotypic changes in infants of hepatitis B surface antigen positive mothers compared with normal and hepatitis B surface antigen negative infants at birth and 1 year after HBV immunization. Hepatitis B surface antigen positive infants had higher immature transitional B cells at birth, which normalized a year after immunization. Immature B-cell response to neonatal HBV exposure is associated with maternal-child transmission of HBV.
authors.affiliation: Department of Research, Institute of Liver and Biliary Sciences, New Delhi, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Shrivastava
authors.forename: Nirupama
authors.initials: N
authors.lastname: TrehanPati
authors.forename: Shyam
authors.initials: S
authors.lastname: Kottilil
authors.forename: Shiv Kumar
authors.initials: SK
authors.lastname: Sarin
mesh_terms: D005260:Female; D006509:Hepatitis B / Q000276:immunology* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D054448:Precursor Cells, B-Lymphoid / Q000276:immunology*; D011247:Pregnancy
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines