title: Tocopherols and tocotrienols as anticancer treatment for lung cancer: future nutrition.
abstract: Nutrition has been known for ages to shield the immune system against several formulations that deregulate normal DNA repair mechanisms, and induce tumorigenesis. Vitamins and in specific Vit E and its members tocopherols (α-, β-, γ-, δ-) and tocotrienols (α-, β-, γ-, δ-) have demonstrated strong association with the prevention of cancer and inhibition of tumor, both in vitro and in vivo. Vitamin E has also demonstrated effective role against chemotherapy resistant cancer cell evolution and a protective role in acute interstitial disease. Several formulations of Vitamin E have been investigated conjugated with different carriers as nano-formulations and administered in different forms. Additionally, several tumorigenic pathways have been investigated separately in an effort to identify which member of Vitamin E inhibits efficiently every pathway. Vitamin E presented efficiency against specific subhistology types of lung cancer. Finally, in the current work up to date information regarding novel formulations with Vitamin E and inhibition pathways are going to be presented and commented.
authors.affiliation: Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; ; University Pulmonary Department, "Ruhrland" Clinic, University of Duisburg-Essen, Essen, Germany;
authors.forename: Paul
authors.initials: P
authors.lastname: Zarogoulidis
authors.forename: Aggeliki
authors.initials: A
authors.lastname: Cheva
authors.forename: Katerina
authors.initials: K
authors.lastname: Zarampouka
authors.forename: Haidong
authors.initials: H
authors.lastname: Huang
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Katsikogiannis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Zarogoulidis
keywords: Vitamin E; lung cancer; nanomedicine; nutrition; tocopherol; tocotrienol