title: Bioinformatics analysis of breast cancer bone metastasis related gene-CXCR4.
abstract: OBJECTIVE
  To analyze breast cancer bone metastasis related gene-CXCR4.
  
  
  METHODS
  This research screened breast cancer bone metastasis related genes by high-flux gene chip.
  
  
  RESULTS
  It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations. The expression of chemokine receptor CXCR4 was obviously up-regulated in the tissue with breast cancer bone metastasis. Compared with the tissue without bone metastasis, there was significant difference, which indicated that CXCR4 played a vital role in breast cancer bone metastasis.
  
  
  CONCLUSIONS
  The bioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis, target gene therapy and evaluation of prognosis.
authors.affiliation: Department of Breast, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China.
authors.forename: Heng-Wei
authors.initials: HW
authors.lastname: Zhang
authors.forename: Xian-Fu
authors.initials: XF
authors.lastname: Sun
authors.forename: Ya-Ning
authors.initials: YN
authors.lastname: He
authors.forename: Jun-Tao
authors.initials: JT
authors.lastname: Li
authors.forename: Xu-Hui
authors.initials: XH
authors.lastname: Guo
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D019295:Computational Biology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis; D019718:Receptors, CXCR4 / Q000737:chemistry* / Q000235:genetics*; D016415:Sequence Alignment; D015854:Up-Regulation
chemical_list: C527276:CXCR4 protein, human; D019718:Receptors, CXCR4
keywords: Bioinformatics analysis; Breast cancer bone metastasis; CXCR4