title: Selective copper(II) acetate and potassium iodide catalyzed oxidation of aminals to dihydroquinazoline and quinazolinone alkaloids.
abstract: Copper(II) acetate/acetic acid/O2 and potassium iodide/tert-butylhydroperoxide systems are shown to affect the selective oxidation of ring-fused aminals to dihydroquinazolines and quinazolinones, respectively. These methods enable the facile preparation of a number of quinazoline alkaloid natural products and their analogues.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Richers
authors.forename: Chenfei
authors.initials: C
authors.lastname: Zhao
authors.forename: Daniel
authors.initials: D
authors.lastname: Seidel
keywords: aminal; copper; oxygen; quinazoline alkaloid; tert-butylhydroperoxide