title: Antifungal activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone derivatives.
abstract: Thiazolidinones, synthesized from multicomponent reactions of 2-heteroarylmethylamine, arenealdehydes and mercaptoacetic acid, have been tested against six yeasts, namely Candida albicans, C. parapsilosis, C. guilliermondii, Cryptococcus laurentii, Trichosporon asahii and Rhodotorula spp. The activities were expressed as minimum inhibitory concentrations (MIC) and the minimum fungicidal concentrations (MFC). The most affected yeasts were Rhodotorula spp and T. asahii. The cytotoxicities of the thiazolidinones against the fibroblast 3T3/NIH cell line are also described. The antifungal results and the low cytotoxicity of the compounds in this work provide good guides for the further development of active compounds.
authors.forename: Gabriela H
authors.initials: GH
authors.lastname: Marques
authors.forename: Alice
authors.initials: A
authors.lastname: Kunzler
authors.forename: Valéria D O
authors.initials: VD
authors.lastname: Bareño
authors.forename: Bruna B
authors.initials: BB
authors.lastname: Drawanz
authors.forename: Hellen G
authors.initials: HG
authors.lastname: Mastelloto
authors.forename: Fabio R M
authors.initials: FR
authors.lastname: Leite
authors.forename: Gustavo G
authors.initials: GG
authors.lastname: Nascimento
authors.forename: Patrícia S
authors.initials: PS
authors.lastname: Nascente
authors.forename: Geonir M
authors.initials: GM
authors.lastname: Siqueira
authors.affiliation: Universidade Federal de Pelotas, CCQFA, R. Gomes Carneiro 1, caixa postal 354, CEP: 96001-970, Brazil. wjcunico@yahoo.com.br.
authors.forename: Wilson
authors.initials: W
authors.lastname: Cunico
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D012248:Rhodotorula / Q000187:drug effects*; D013329:Structure-Activity Relationship; D053778:Thiazolidines / Q000737:chemistry / Q000494:pharmacology*; D014250:Trichosporon / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D053778:Thiazolidines