title: [Observations on fatigue, depression and quality of life in patients with Parkinson's disease].
abstract: OBJECTIVE
  To identify the association between fatigue and depression in Parkinson's disease (PD).
  
  
  METHODS
  56 PD patients were enrolled in this study. The degree of fatigue was measured by Fatigue Severity Scale (FSS). Hamilton Depression Scale (24 items) was used to evaluate the degree of depression. PD Quality of Life Questionnaire (PDQL) were tested to evaluate the quality of life in PD patients. While other clinical information such as Unified Parkinson's Disease Rating Scale (UPDRS) III, Hoehn-Yahr Scale and modified Webster Scale were investigated.
  
  
  RESULTS
  The incidence of fatigue in this group is 71.4% (40/56). Score of HAMD and PDQL exhibited a significant correlation to patients' fatigue, coefficient of partial correlation was 0.451 (P < 0.01), -0.346 (P < 0.05). The incidence of fatigue in non-depressive patients was low, 27.3%. While in depressive patients, the incidence of fatigue is relatively high, for mild depression 75%, moderate depression 100%, severe depression 100% respectively.
  
  
  CONCLUSIONS
  Fatigue is a prominent symptom of depression in PD patients, sometimes independent of depression also influencing the patients' quality of life.
authors.affiliation: Department of Neurology, 2nd Affiliated Hospital of Soochow University, Suzhou 215004, China.
authors.forename: Cheng-jie
authors.initials: CJ
authors.lastname: Mao
authors.forename: Li-dan
authors.initials: LD
authors.lastname: Cao
authors.forename: Qing
authors.initials: Q
authors.lastname: Tang
authors.forename: Chun-feng
authors.initials: CF
authors.lastname: Liu
mesh_terms: D000368:Aged; D003863:Depression / Q000209:etiology*; D005221:Fatigue / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D011788:Quality of Life; D011795:Surveys and Questionnaires