title: [Vasodilatation caused by endogenous hydrogen sulfide in chronic renal failure].
abstract: Hydrogen sulfide, (H2S), is an endogenous gas which exerts a protective function in several biological processes, including those involved in inflammation, blood pressure regulation, and energy metabolism. The enzymes involved in H2S production are cysthationine -synthetase, cysthationine -lyase and 3-mercaptopyruvate sulfurtransferase. Low plasma H2S levels have been found in chronic renal failure (CRF) in both humans and animal models. The mechanisms leading to H2S deficiency in CRF are linked to reduced gene expression of cysthationine -lyase. Intense research is currently under way to discover the link between low H2S levels, CRF progression and the uremic syndrome and to determine whether therapeutic interventions aimed at increasing H2S levels might benefit these patients.
authors.forename: Alessandra Fortunata
authors.initials: AF
authors.lastname: Perna
authors.forename: Diana
authors.initials: D
authors.lastname: Lanza
authors.forename: Immacolata
authors.initials: I
authors.lastname: Sepe
authors.forename: Annarita
authors.initials: A
authors.lastname: Di Nunzio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Conzo
authors.forename: Ersilia
authors.initials: E
authors.lastname: Satta
authors.forename: Giovanbattista
authors.initials: G
authors.lastname: Capasso
authors.forename: Diego
authors.initials: D
authors.lastname: Ingrosso
mesh_terms: D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis / Q000235:genetics; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology; D002478:Cells, Cultured; D003545:Cysteine / Q000378:metabolism; D018450:Disease Progression; D004790:Enzyme Induction; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D007249:Inflammation; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D015227:Lipid Peroxidation; D008190:Lyases / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D018384:Oxidative Stress; D051381:Rats; D014664:Vasodilation / Q000502:physiology*
chemical_list: D051017:Apoptosis Regulatory Proteins; D006710:Homocysteine; D008190:Lyases; C019965:cystathionine beta-lyase; D003545:Cysteine; D006862:Hydrogen Sulfide