title: Influence of the body mass and visceral adiposity on glucose metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene.
abstract: BACKGROUND
  Glucose metabolism may be altered in obesity and genotype for PPAR 2 can influence this variable.
  
  
  OBJECTIVE
  To evaluate the influence of body mass (BM) and visceral adiposity (VA) in glucose metabolism in morbid obese women with Pro12Pro genotype.
  
  
  METHODS
  Were selected 25 morbidly obese women. Groups were formed according to body mass index (BMI) [G1: 40-45 kg/m² (n = 17); G2: > 45 kg/m² (n = 8)]. Anthropometric, glycemia and insulinemia assessments (fasting, 60 and 120 minutes after high polyunsaturated fatty acids meal) were carried out. The insulin resistance (IR) and insulin sensitivity (IS) were assessed by HOMA-IR and QUICKI respectively.
  
  
  RESULTS
  G2 had higher BMI and waist circumference, compared to G1, impaired fasting glucose, low IS and higher IR. The postprandial glucose was normal, but there was a higher insulin peak one hour after the meal in G2.
  
  
  CONCLUSIONS
  Increased BM and VA were associated with worse glucose metabolism suggesting metabolic differences between morbid obese with Pro12Pro genotype.
authors.affiliation: Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Brazil.
authors.forename: Vanessa Chaia
authors.initials: VC
authors.lastname: Kaippert
authors.forename: Sofia Kimi
authors.initials: SK
authors.lastname: Uehara
authors.forename: Carla Lima
authors.initials: CL
authors.lastname: D'Andrea
authors.forename: Juliana
authors.initials: J
authors.lastname: Nogueira
authors.forename: Márcia Fófano
authors.initials: MF
authors.lastname: do Lago
authors.forename: Marcelly
authors.initials: M
authors.lastname: Cunha Oliveira dos Santos Lopes
authors.forename: Edna Maria Morais
authors.initials: EM
authors.lastname: Oliveira
authors.forename: Eliane Lopes
authors.initials: EL
authors.lastname: Rosado
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050152:Intra-Abdominal Fat; D008875:Middle Aged; D009767:Obesity, Morbid / Q000235:genetics* / Q000378:metabolism*; D047495:PPAR gamma / Q000235:genetics*; D055815:Young Adult
chemical_list: D047495:PPAR gamma; D005947:Glucose