title: A health food high-peptide meal alleviates immunosuppression induced by hydrocortisone and cyclophosphamide in mice.
abstract: This study set out to determine the immunomodulatory effects of a health food high-peptide meal in immunodeficient mice that was induced by either hydrocortisone (HY) or cyclophosphamide (CP). Five separate trials were performed in which animals were randomly divided into 5 groups of 12 mice for each experimental trial. Group 1 served as the vehicle control. Animals assigned to groups 3-5 (dose groups), were each administered once daily with 1.67, 3.33 or 6.67 g kg(-1) body weight of a high-peptide meal, respectively, for 30 consecutive days. Animals from groups 2 to 5 that were included in trials 1 to 4, each received an intramuscular administration of HY at 40 mg kg(-1) body weight on days 22, 24, 26, 28, 30. Animals from groups 2-5, in trial 5, each received an intraperitoneal administration of CP at 50 mg kg(-1) body weight, on days 26 and 27. On day 31, all groups of mice were differentially screened for immunomodulatory activity following the conclusion of the above experiments. In HY-treated mice, the high-peptide meal accelerated the recovery of the phagocytic function of both macrophages and the reticuloendothelial system, and restored NK cell activity. In CP-treated mice, the high-peptide meal promoted a humoral immune response to sheep red blood cells (SRBCs). These results demonstrated the immunomodulatory effects of a high-peptide meal.
authors.affiliation: Center for Disease Control and Prevention of Guangdong Province, 160 Qun Xian Road, Pan Yu District, Guangzhou, China.
authors.forename: Lv
authors.initials: L
authors.lastname: Yingjian
authors.forename: Huang
authors.initials: H
authors.lastname: Junming
authors.forename: Cai
authors.initials: C
authors.lastname: Min
authors.forename: Li
authors.initials: L
authors.lastname: Chenyue
authors.forename: Zhang
authors.initials: Z
authors.lastname: Dachao
authors.forename: Hu
authors.initials: H
authors.lastname: Yuanhua
authors.forename: Li
authors.initials: L
authors.lastname: Zhi
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003520:Cyclophosphamide / Q000009:adverse effects*; D004044:Dietary Proteins / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D023381:Endpoint Determination; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D058870:Food, Organic; D006461:Hemolysis; D006854:Hydrocortisone / Q000009:adverse effects*; D006967:Hypersensitivity / Q000188:drug therapy; D056747:Immunomodulation; D007165:Immunosuppression Therapy; D007694:Killer Cells, Natural / Q000187:drug effects / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D062407:Meals; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000187:drug effects / Q000378:metabolism; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D004044:Dietary Proteins; D003520:Cyclophosphamide; D006854:Hydrocortisone