title: Accounting for functional loss in Alzheimer's disease and dementia with Lewy bodies: beyond cognition.
abstract: BACKGROUND
  The relative contributions of cognitive, motor, and behavioral deficits to the impairment of physical or instrumental activities of daily living (ADLs) may differ in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD).
  
  
  METHODS
  Multiple linear regression analyses were used to identify the amount of variability in physical self-maintenance and instrumental ADL ratings predicted by cognitive, motor, and behavioral indices separately for patients with autopsy-diagnosed DLB (n = 39) or AD (n = 39).
  
  
  RESULTS
  Motor dysfunction accounted for significant variance in physical ADLs in DLB (R(2) change = 0.17), whereas behavioral (R(2) change = 0.23) and motor dysfunction (R(2) change = 0.13) accounted for significant variance in AD. Motor (R(2) change = 0.32) and cognitive (R(2) change = 0.10) dysfunction accounted for significant variance in instrumental ADLs in DLB, whereas cognitive (R(2) change = 0.36) and behavioral (R(2) change = 0.12) dysfunction accounted for significant variance in AD.
  
  
  CONCLUSIONS
  Cognitive, motor, and behavioral deficits contribute differently to ADL changes in DLB and AD. Thus, treatments designed to ameliorate a certain aspect of AD or DLB (e.g., cognitive dysfunction) may have a larger impact on everyday functioning in one disorder than the other.
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. Electronic address: jhamilton@anhsocal.com.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Hamilton
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Salmon
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Rema
authors.initials: R
authors.lastname: Raman
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Pathology, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Hansen
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Pathology, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Eliezer
authors.initials: E
authors.lastname: Masliah
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Guerry M
authors.initials: GM
authors.lastname: Peavy
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Neurology Service, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Galasko
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D001526:Behavioral Symptoms / Q000209:etiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis / Q000209:etiology*; D009483:Neuropsychological Tests; D012044:Regression Analysis
keywords: Activities of daily living; Alzheimer's disease; Behavior; Cognition; Dementia with Lewy bodies; Motor function