title: The use of an anti-inflammatory supplement in patients with chronic kidney disease.
abstract: Chronic kidney disease (CKD) is characterized by a continuous reduction in kidney function, increased inflammation, and reduced antioxidant capacity. The objective of this study was to assess the effects of a herbal supplement on systemic inflammation and antioxidant status in non-dialysis CKD patients. Sixteen patients with CKD (56.0±16.0 yrs, 171.4±11.9 cm, 99.3±20.2 kg) were randomly chosen to receive a herbal supplement composed of Curcuma longa and Boswellia serrata, or placebo. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), glutathione peroxidase (GPx), and serum C-reactive protein (CRP) were measured at baseline and 8 weeks. Baseline data demonstrated elevated inflammation and low antioxidant levels. A significant time effect (p=0.03) and time x compliance interaction effect (p=0.04) were observed for IL-6. No significant differences were observed for any other variables. This study demonstrates that mild and moderate CKD is associated with chronic inflammation and low antioxidant activity. Systemic inflammation and impaired antioxidant status may be greater in CKD populations with multiple comorbidities. Curcumin and Boswellia serrata are safe and tolerable and helped to improve the levels of an inflammatory cytokine.
authors.affiliation: Baylor University, Waco, TX, USA. jen_moreillon@baylor.edu
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Moreillon
authors.forename: Rodney G
authors.initials: RG
authors.lastname: Bowden
authors.forename: Erika
authors.initials: E
authors.lastname: Deike
authors.forename: Jackson
authors.initials: J
authors.lastname: Griggs
authors.forename: Ron
authors.initials: R
authors.lastname: Wilson
authors.forename: Brian
authors.initials: B
authors.lastname: Shelmadine
authors.forename: Matt
authors.initials: M
authors.lastname: Cooke
authors.forename: Alexander
authors.initials: A
authors.lastname: Beaujean
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D029743:Boswellia; D002097:C-Reactive Protein / Q000378:metabolism; D030024:Curcuma; D019587:Dietary Supplements; D004338:Drug Combinations; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004338:Drug Combinations; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D005979:Glutathione Peroxidase