title: The MPO-463G>A polymorphism and lung cancer risk: a meta-analysis based on 22 case-control studies.
abstract: BACKGROUND
  Myeloperoxidase (MPO) is an endogenous oxidant enzyme that produces reactive oxygen species (ROS) and may be involved in lung carcinogenesis. The MPO-463G>A polymorphism influences MPO transcription and has been associated with lung cancer susceptibility. However, the association between the MPO-463G>A polymorphism and lung cancer risk remains controversial.
  
  
  METHODS
  To investigate the effect of this polymorphism on lung cancer susceptibility, we performed a meta-analysis based on 22 published case-control studies including 7,520 patients with lung cancer and 8,600 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.
  
  
  RESULTS
  Overall, there was no evidence for significant association between MPO-463G>A polymorphism and lung cancer susceptibility (for AA versus GG: OR = 0.91, 95%CI = 0.67-1.24; for GA versus GG: OR = 0.87, 95% CI = 0.78-0.98; for AA/GA versus GG: OR = 0.90, 95% CI = 0.80-1.01; for AA versus
  OR = 0.96, 95% CI = 0.72-1.28). In the stratified analyses by ethnicity, source of controls and smoking status, we also did not find any significant association between them.
  
  
  CONCLUSIONS
  In summary, this meta-analysis suggests MPO-463G>A polymorphism may not be a risk factor for developing lung cancer. However, further prospective well-designed population-based studies with larger sample size are expected to validate the results.
authors.affiliation: Department of Radiotherapy Oncology, The Third Affiliated Hospital of Wuhan University, Wuhan, Hubei, PR China.
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Yang
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Wang
authors.forename: Xiao-Xi
authors.initials: XX
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Ren
authors.forename: Fu-Xiang
authors.initials: FX
authors.lastname: Zhou
authors.forename: Liu
authors.initials: L
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Bai-Yu
authors.initials: BY
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Huan-Gang
authors.initials: HG
authors.lastname: Jiang
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Zhou
mesh_terms: D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008957:Models, Genetic; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D009195:Peroxidase