title: Plasma gel as a new augmentation material for injection laryngoplasty in rabbit model: histologic analysis.
abstract: OBJECTIVE
  Currently, a variety of materials are available for the treatment of glottal insufficiency. Ideal injection materials should be inexpensive, easily obtainable, nontoxic, and biocompatible. Plasma gel has recently been developed as an injectable, autologous material used in plastic surgery. The aim of this study was to evaluate the histological changes in rabbit vocal folds (VFs) after an injection of plasma gel, compared with collagen (Artecoll) or hyaluronic acid (Reviderm Intra).
  
  
  METHODS
  Experimental prospective animal study.
  
  
  METHODS
  Animal laboratory.
  
  
  METHODS
  Blood samples were collected from 12 New Zealand rabbits. Plasma collected from each rabbit was centrifuged and processed using a gel heating system. All rabbits received a 0.05 ml injection of plasma gel into the right VF, while an equivalent volume of Artecoll or Reviderm Intra was injected into the left VFs of each 6 rabbits randomly. The larynges were collected 2, 4, and 8 weeks after injection, and the tissues were stained for histological analysis.
  
  
  RESULTS
  In comparison with left VFs injected with Artecoll or Reviderm Intra, there was significantly less inflammatory response and foreign body reaction in the plasma gel injected right VFs (P < .05). Multinucleated foreign body type giant cells were also more prevalent in the left VFs. There were no quantitative differences in the rates of neovascularization or collagen deposition between groups.
  
  
  CONCLUSIONS
  Plasma gel is a biologically compatible material that may serve as a suitable augmentation material in injection laryngoplasty. Further studies that examine the long-term effects in a larger number of subjects are needed.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Seok Jin
authors.initials: SJ
authors.lastname: Hong
authors.forename: Sang Hyuk
authors.initials: SH
authors.lastname: Lee
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Jin
authors.forename: Seon Uk
authors.initials: SU
authors.lastname: Lee
authors.forename: Se Hyung
authors.initials: SH
authors.lastname: Huh
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Kwon
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Woo
mesh_terms: D000818:Animals; D003094:Collagen / Q000008:administration & dosage; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D005549:Foreign-Body Reaction / Q000453:epidemiology; D005782:Gels / Q000008:administration & dosage; D006820:Hyaluronic Acid / Q000008:administration & dosage; D058753:Laryngoplasty; D008297:Male; D008863:Microspheres; D023421:Models, Animal; D010949:Plasma; D019904:Polymethyl Methacrylate / Q000008:administration & dosage; D011817:Rabbits; D014681:Velopharyngeal Insufficiency / Q000601:surgery*; D014827:Vocal Cords / Q000473:pathology
chemical_list: C445359:Artecoll; D015718:Fibrin Tissue Adhesive; D005782:Gels; D006820:Hyaluronic Acid; D003094:Collagen; D019904:Polymethyl Methacrylate
keywords: histology; laryngoplasty; plasma; rabbit; vocal fold