title: Acute hepatitis associated with clopidogrel: a case report and review of the literature.
abstract: Drug-induced hepatotoxicity is a common cause of acute hepatitis, and the recognition of the responsible drug may be difficult. We describe a case of clopidogrel-related acute hepatitis. The diagnosis is strongly suggested by an accurate medical history and liver biopsy. Reports about cases of hepatotoxicity due to clopidogrel are increasing in the last few years, after the increased use of this drug. In conclusion, we believe that physicians should carefully consider the risk of drug-induced hepatic injury when clopidogrel is prescribed.
authors.affiliation: 1Hepatology Unit; and 2Anatomopathology Unit, National Institute for Infectious Diseases "L. Spallanzani," Rome, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Pisapia
authors.forename: Amina
authors.initials: A
authors.lastname: Abdeddaim
authors.forename: Andrea
authors.initials: A
authors.lastname: Mariano
authors.forename: Alessia
authors.initials: A
authors.lastname: Rianda
authors.forename: Laura
authors.initials: L
authors.lastname: Vincenzi
authors.forename: Chiara
authors.initials: C
authors.lastname: Taibi
authors.forename: Andrea
authors.initials: A
authors.lastname: Baiocchini
authors.forename: Franca
authors.initials: F
authors.lastname: Del Nonno
authors.forename: Gianpiero
authors.initials: G
authors.lastname: DʼOffizi
mesh_terms: D000208:Acute Disease; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D000077144:Clopidogrel; D005260:Female; D006801:Humans; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine