title: Risks of Breast and Endometrial Cancer in Women with Diabetes: A Population-Based Cohort Study.
abstract: We investigated the overall and age-specific risks of developing breast and endometrial cancer among women with diabetes in a population-based cohort study.
  
  
  
  Women with diabetes (n = 319310) and age-matched controls (n = 319308), selected from ambulatory care claims and beneficiary registry in 2000, respectively were linked to the in-patient claims (2000-2008) to identify admissions due to breast (ICD-9-CM: 174) and endometrial (ICD-9-CM: 182) cancer. The person-year approach with Poisson assumption was used to estimate the incidence density rate. The age-specific hazard ratios (HRs) of above malignancies in relation to diabetes with multivariate Cox proportional hazard regression.
  
  
  
  The overall incidence density rate of breast and endometrial cancer was estimated at 1.21 and 0.21 per 10,000 patient-years, respectively, for diabetes. The corresponding figures for controls were lower at 1.00 and 0.14 per 10,000 patient-years. Compared with the controls, the covariate adjusted HR for breast and endometrial cancer was 1.42 (95% confidence interval (CI) 1.34-1.50) and 1.71 (95% CI 1.48-1.97), respectively in women with diabetes. Elderly (> = 65 years) diabetes had the highest HR (1.61) of breast cancer, while the highest HR (1.85) of endometrial cancer was observed in diabetes aged < = 50 years.
  
  
  
  Diabetes may significantly increase the risks of breast and endometrial cancer in all age stratifications. Health education for strict adherence of cancer screening program in women with diabetes is essential.
authors.affiliation: Department of Endocrinology, Far Eastern Memorial Hospital, New Taipei City, Taiwan ; School of Medicine, Fujen Catholic University, New Taipei City, Taiwan.
authors.forename: Hua-Fen
authors.initials: HF
authors.lastname: Chen
authors.forename: Ming-Der
authors.initials: MD
authors.lastname: Liu
authors.forename: Peter
authors.initials: P
authors.lastname: Chen
authors.forename: Li-Huan
authors.initials: LH
authors.lastname: Chen
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Chang
authors.forename: Pei-Chun
authors.initials: PC
authors.lastname: Wen
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Li
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000453:epidemiology / Q000209:etiology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D013624:Taiwan / Q000453:epidemiology