title: Model fluids representing aqueous in-vitro diagnostic reagents for the development of dispensing systems.
abstract: Analyzers for in-vitro diagnostic (IVD) testing facilitate the determination of medical information from biological samples. To reach a high quality, the detection reagents have to be dispensed with a high degree of precision and accuracy. A technology change from conventional pipetting systems to contact-free dispensers provides the opportunity to reduce carry-over and handle reagents in the microliter range. A great challenge for the development and validation of new systems is the huge variety of the IVD reagents. This work presents the fluidic properties of 646 different aqueous IVD reagents and how they can be represented by a set of easy-to-prepare model fluids, covering the rheological range of the reagents. In addition, based on the model fluids, a standardized approach is presented for the evaluation of dispensers for IVD applications.
authors.affiliation: Roche Diagnostics GmbH, Sandhofer Str. 116, 68305 Mannheim, Germany; Laboratory for MEMS Applications, IMTEK - Department of Microsystems Engineering, University of Freiburg, Georges-Koehler-Allee 103, 79110 Freiburg, Germany. Electronic address: nadine.losleben@roche.com.
authors.forename: Nadine
authors.initials: N
authors.lastname: Losleben
authors.forename: Jürgen
authors.initials: J
authors.lastname: Spinke
authors.forename: Sabrina
authors.initials: S
authors.lastname: Adler
authors.forename: Norbert
authors.initials: N
authors.lastname: Oranth
authors.forename: Roland
authors.initials: R
authors.lastname: Zengerle
mesh_terms: D019937:Diagnostic Techniques and Procedures / Q000295:instrumentation* / Q000592:standards; D004867:Equipment Design; D006801:Humans; D007202:Indicators and Reagents / Q000737:chemistry*; D015203:Reproducibility of Results; D012212:Rheology
chemical_list: D007202:Indicators and Reagents