title: [Synthesis and bioactivity of the folate receptor targeted gamma-cyclodextrin-folate inclusion-coated CdSe/ZnS quantum dots].
abstract: The gamma-cyclodextrin-folate (gamma-CD/FA) inclusion-coated CdSe/ZnS quantum dots (QDs) with folate-receptor (FR) targeted were synthesized by simple and convenient sonochemical method. The products were studied using Fourier transform infrared (FTIR), proton nuclear magnetic resonance (1H NMR), utraviolet-visible spectrometry (UV-vis), fluorescence spectrum and transmission electron micrographs (TEM). The results showed that the gamma-CD/FA-coated CdSe/ZnS QDs not only have good monodispersity and smaller size, but also have good optical performance, such as higher quantum yield (QY) and a long fluorescence lifetime. The cytotoxicity experiments showed that the gamma-CD/FA-coated CdSe/ZnS QDs have lower cytotoxicity and could more effectively enter cancer cells with FR over-expression. The QDs with 4-5 nm in diameter were relatively easy to enter the cell and to be removed through kidneys, so it is more suitable for biomedical applications for bioprobes and bioimaging.
authors.affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng 475004, China. zhaomeixia2011@henu.edu.cn
authors.forename: Mei-Xia
authors.initials: MX
authors.lastname: Zhao
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Chao-Jie
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D019187:Cadmium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D058975:Folate Receptor 1 / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D057054:Molecular Imaging / Q000379:methods; D045663:Quantum Dots / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D018036:Selenium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D017967:Zinc Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D047408:gamma-Cyclodextrins / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D058975:Folate Receptor 1; D018036:Selenium Compounds; D013440:Sulfides; D017967:Zinc Compounds; D047408:gamma-Cyclodextrins; D005492:Folic Acid; C058667:cadmium selenide; C031238:zinc sulfide; C023792:gamma-cyclodextrin