title: Crystalline calcium alendronate obtained by octacalcium phosphate digestion: a new chance for local treatment of bone loss diseases?
abstract: Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP.
authors.affiliation: Department of Chemistry "Giacomo Ciamician", University of Bologna, Via Selmi, 2, 40126 Bologna, Italy. elisa.boanini@unibo.it.
authors.forename: Elisa
authors.initials: E
authors.lastname: Boanini
authors.forename: Paola
authors.initials: P
authors.lastname: Torricelli
authors.forename: Massimo
authors.initials: M
authors.lastname: Gazzano
authors.forename: Milena
authors.initials: M
authors.lastname: Fini
authors.forename: Adriana
authors.initials: A
authors.lastname: Bigi
mesh_terms: D019386:Alendronate / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D001862:Bone Resorption / Q000188:drug therapy*; D002118:Calcium / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000737:chemistry* / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003460:Crystallization; D006801:Humans; D008958:Models, Molecular; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010316:Particle Size; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D002130:Calcium Phosphates; D002118:Calcium; D019386:Alendronate
keywords: bisphosphonate; in vitro co-cultures; octacalcium phosphate