title: Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma.
abstract: The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene was originally identified as a transformation suppressor gene that is widely expressed in normal tissues. In tumor tissues,RECKexpression levels are significantly reduced, and the downregulation ofRECKhas been implicated in tumors that are more aggressive with a poor prognosis. In the present study,RECKexpression in peripheral T-cell lymphoma (PTCL; n=82) was examined using immunohistochemistry, and its correlation with clinicopathological factors was analyzed. According to the proportion of positively-stained cells and the staining intensity (SI), the patients were categorized intoRECK-negative orRECK-positive groups.RECKexpression was observed in 30 of the 82 patients (36.6%). The 3-year survival rate of the patients withRECK-positive tumors (65.5%) was significantly high compared with that of the patients withRECK-negative tumors (20.3%; P=0.046). ReducedRECKexpression was found to be significantly correlated with extranodal lymphomatous involvement (P=0.012). The survival analysis showed thatRECK-negative expression was an independent and significant factor for predicting a poor prognosis.RECKstatus is a useful prognostic factor for assessing the biological behavior in PTCL.
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Mao
authors.forename: Longlong
authors.initials: L
authors.lastname: Liu
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Donghua
authors.initials: D
authors.lastname: Zhang
keywords: peripheral T-cell lymphoma; prognosis; reversion-inducing cysteine-rich protein with Kazal motifs