title: Predictive accuracy of covariates for event times.
abstract: We propose a graphical measure, the generalized negative predictive function, to quantify the predictive accuracy of covariates for survival time or recurrent event times. This new measure characterizes the event-free probabilities over time conditional on a thresholded linear combination of covariates and has direct clinical utility. We show that this function is maximized at the set of covariates truly related to event times and thus can be used to compare the predictive accuracy of different sets of covariates. We construct nonparametric estimators for this function under right censoring and prove that the proposed estimators, upon proper normalization, converge weakly to zero-mean Gaussian processes. To bypass the estimation of complex density functions involved in the asymptotic variances, we adopt the bootstrap approach and establish its validity. Simulation studies demonstrate that the proposed methods perform well in practical situations. Two clinical studies are presented.
authors.affiliation: Markey Cancer Center and Department of Biostatistics, University of Kentucky, Lexington, Kentucky 40536, U.S.A. , lichenuky@uky.edu.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: D Y
authors.initials: DY
authors.lastname: Lin
authors.forename: Donglin
authors.initials: D
authors.lastname: Zeng
keywords: Censoring; Negative predictive value; Positive predictive value; Prognostic accuracy; Receiver operating characteristic curve; Recurrent event; Survival data; Transformation model