title: [An autopsy of a case of pulmonary hypertension secondary to pulmonary embolization of intrahepatic cholangiocarcinoma].
abstract: A 70-year-old woman was admitted to our hospital for one month because of progressive dyspnea. Her medical history included an operation for hepatolithiasis at age 47. She was a current smoker. Chest CT revealed emphysematous change and honeycombing in the lung and bilateral subpleural opacifications. Cardiac ultrasound examination showed pulmonary hypertension. Treatments with antibiotics, corticosteroids and heparin were unsuccessful. Despite mechanical ventilation, she died of respiratory failure. Autopsy revealed that intrahepatic cholangiocarcinoma had spread via the hematogeneous route, formed multiple emboli into the pulmonary small arteries, and led to severe pulmonary hypertension and lung infarction.
authors.affiliation: Dept. of Respiratory Medicine, Osaka General Medical Center.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakanishi
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Tanio
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tagawa
authors.forename: Taisuke
authors.initials: T
authors.lastname: Akiyama
authors.forename: Junpei
authors.initials: J
authors.lastname: Takashima
authors.forename: Masaharu
authors.initials: M
authors.lastname: Motone
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kawai
authors.forename: Takumi
authors.initials: T
authors.lastname: Kondo
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shimazu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Fushimi
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Miki
mesh_terms: D000368:Aged; D001344:Autopsy; D001650:Bile Duct Neoplasms / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D009360:Neoplastic Cells, Circulating / Q000473:pathology*