title: HIT: nucleic acid masquerading as heparin.
abstract: In this issue of Blood, Jaax and colleagues show that heparin-PF4 antibodies cross-reacted with nucleic acid (NA)–PF4 complexes and induced platelet activation, suggesting that NA-PF4 can potentially cause a heparin-induced thrombocytopenia (HIT)–like prothrombotic disorder.
authors.affiliation: New South Wales University.
authors.forename: Beng H
authors.initials: BH
authors.lastname: Chong
authors.forename: James J-H
authors.initials: JJ
authors.lastname: Chong
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000378:metabolism*; D006801:Humans; D009696:Nucleic Acids / Q000378:metabolism*; D010978:Platelet Factor 4 / Q000276:immunology* / Q000378:metabolism*
chemical_list: D052157:Aptamers, Nucleotide; D009696:Nucleic Acids; D010978:Platelet Factor 4