title: Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity.
abstract: Pathways that regulate epigenetic control of stem cell identity are critical to the molecular etiology of cancer. In back-to-back articles in Cell and Cell Stem Cell, Song et al. identify miR-22 as both a repressor of TET proteins and a powerful oncogene in the mammary epithelium and hematopoietic system.
authors.affiliation: Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA. pdalerba@stanford.edu
authors.forename: Piero
authors.initials: P
authors.lastname: Dalerba
authors.forename: Michael F
authors.initials: MF
authors.lastname: Clarke
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D042002:Chromatin Assembly and Disassembly; D004268:DNA-Binding Proteins / Q000378:metabolism*; D049308:Dioxygenases; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D019337:Hematologic Neoplasms / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism* / Q000502:physiology; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D035683:MicroRNAs; C574876:Mirn22 microRNA, mouse; D011518:Proto-Oncogene Proteins; D049308:Dioxygenases; C541081:TET2 protein, human