title: Protective effect of Hygrophila spinosa against cisplatin induced nephrotoxicity in rats.
abstract: OBJECTIVE
  To evaluate the nephroprotective effect of methanolic extract of Hygrophila spinosa (HSME) (Acanthaceae) in (CP)-induced acute renal failure in rats.
  
  
  METHODS
  HSME (250 mg/kg and 500 mg/kg body weight), were administered orally to male wistar albino rats.CP was used to induce acute renal failure. The parameters studied included blood urea and serum creatinine and malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and GSH peroxidase activities. Histopathological examination was also carried out.
  
  
  RESULTS
  The results revealed that HSME pretreatment signiûcantly reduced blood urea and serum creatinine levels elevated by CP administration. Furthermore, HSME signiûcantly attenuated CP-induced increase in MDA and decrease in reduced GSH, and CAT and SOD and GSH peroxidase activities in renal cortical homogenates. Additionally, histopathological examination showed that HSME markedly ameliorated CP-induced renal tubular necrosis.
  
  
  CONCLUSIONS
  The results indicate that the aerial parts of H. spinosa are endowed with nephroprotective activity.
authors.affiliation: Department of Pharmacology, AISSMS College of Pharmacy, Pune; KYDSCT's College of Pharmacy, Sakegaon, Bhusawal, India.
authors.forename: Kundan G
authors.initials: KG
authors.lastname: Ingale
authors.forename: Prasad A
authors.initials: PA
authors.lastname: Thakurdesai
authors.forename: Neeraj S
authors.initials: NS
authors.lastname: Vyawahare
mesh_terms: D027901:Acanthaceae; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents; D002374:Catalase / Q000378:metabolism; D002945:Cisplatin; D003404:Creatinine / Q000097:blood; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014508:Urea / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D020011:Protective Agents; D008315:Malondialdehyde; D014508:Urea; D003404:Creatinine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D002945:Cisplatin
keywords: Cisplatin; Hygrophila spinosa; lipid peroxidation; nephrotoxicity