title: Membrane fluidity matters: hyperthermia from the aspects of lipids and membranes.
abstract: Hyperthermia is a promising treatment modality for cancer in combination both with radio- and chemotherapy. In spite of its great therapeutic potential, the underlying molecular mechanisms still remain to be clarified. Due to lipid imbalances and 'membrane defects' most of the tumour cells possess elevated membrane fluidity. However, further increasing membrane fluidity to sensitise to chemo- or radiotherapy could have some other effects. In fact, hyperfluidisation of cell membrane induced by membrane fluidiser initiates a stress response as the heat shock protein response, which may modulate positively or negatively apoptotic cell death. Overviewing some recent findings based on a technology allowing direct imaging of lipid rafts in live cells and lipidomics, novel aspects of the intimate relationship between the 'membrane stress' of tumour cells and the cellular heat shock response will be highlighted. Our findings lend support to both the importance of membrane remodelling and the release of lipid signals initiating stress protein response, which can operate in tandem to control the extent of the ultimate cellular thermosensitivity. Overall, we suggest that the fluidity variable of membranes should be used as an independent factor for predicting the efficacy of combinational cancer therapies.
authors.affiliation: Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
authors.forename: Balint
authors.initials: B
authors.lastname: Csoboz
authors.forename: Gabor E
authors.initials: GE
authors.lastname: Balogh
authors.forename: Erzsebet
authors.initials: E
authors.lastname: Kusz
authors.forename: Imre
authors.initials: I
authors.lastname: Gombos
authors.forename: Maria
authors.initials: M
authors.lastname: Peter
authors.forename: Tim
authors.initials: T
authors.lastname: Crul
authors.forename: Burcin
authors.initials: B
authors.lastname: Gungor
authors.forename: Lajos
authors.initials: L
authors.lastname: Haracska
authors.forename: Gordana
authors.initials: G
authors.lastname: Bogdanovics
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Torok
authors.forename: Ibolya
authors.initials: I
authors.lastname: Horvath
authors.forename: Laszlo
authors.initials: L
authors.lastname: Vigh
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D006979:Hyperthermia, Induced; D050356:Lipid Metabolism; D008560:Membrane Fluidity; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*
chemical_list: D006360:Heat-Shock Proteins