title: Facile synthesis of the necklace-like graphene oxide-multi-walled carbon nanotube nanohybrid and its application in electrochemical sensing of azithromycin.
abstract: A novel electrochemical platform was designed for the determination of Azithromycin (Azi), a widely used macrolide antibiotic, by combining the hydrophilic properties of graphene oxide (GO) and the excellent electronic and antifouling properties of multi-walled carbon nanotubes (MWCNTs). Stable MWCNTs aqueous dispersion has been prepared using GO nano-sheets as surfactant and the obtained GO-MWCNTs nanohybrid was characterized by UV-vis spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, transmission electron microscopy and electrochemical impedance spectroscopy, which confirmed that GO nano-sheets were attached onto the wall of MWCNTs to form a necklace-like structure. Electrochemical results obviously reveal that the oxidation peak currents of Azi obtained at the GC electrode modified with GO-MWCNTs hybrid are much higher than those at the MWCNTs/GC, GO/GC and bare GC electrodes. Under optimized conditions, the anodic peak current was linear to the concentration of Azi in the range from 0.1 to 10 μM with the detection limit of 0.07 μM. To further validate its possible application, the proposed method was successfully used for the determination of Azi in pharmaceutical formulations with satisfactory results.
authors.affiliation: Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China.
authors.forename: Kaixin
authors.initials: K
authors.lastname: Zhang
authors.forename: Limin
authors.initials: L
authors.lastname: Lu
authors.forename: Yangping
authors.initials: Y
authors.lastname: Wen
authors.forename: Jingkun
authors.initials: J
authors.lastname: Xu
authors.forename: Xuemin
authors.initials: X
authors.lastname: Duan
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Dufen
authors.initials: D
authors.lastname: Hu
authors.forename: Tao
authors.initials: T
authors.lastname: Nie
mesh_terms: D017963:Azithromycin / Q000032:analysis / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D006108:Graphite / Q000138:chemical synthesis*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010087:Oxides / Q000138:chemical synthesis*
chemical_list: D037742:Nanotubes, Carbon; D010087:Oxides; D006108:Graphite; D017963:Azithromycin
keywords: Azithromycin; Determination; Graphene oxide; Multi-walled carbon nanotubes; Sensor