title: Psoriasis as autoinflammatory disease.
abstract: This article presents a summary of the evidence for a link between autoinflammatory diseases and psoriasis. The main concepts regarding the disease state of psoriasis are discussed and these lead to a change in the perspective on the clinical and pathophysiologic nature of psoriasis as a chronic, recurrent disease with important genetically defined features, and an associated or concomitant systemic inflammatory state that involves a multifactorial cellular and molecular network, transforming the old perception of psoriasis as a localized autoimmune skin disease, to one of psoriasis as a systemic inflammatory disease with autoinflammatory features and severe associated comorbid conditions.
authors.affiliation: Immunology, Global Medical Affairs, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, USA. bejarano.0214@yahoo.com
authors.forename: Joaquin J
authors.initials: JJ
authors.lastname: Rivas Bejarano
authors.forename: Wendell C
authors.initials: WC
authors.lastname: Valdecantos
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D056660:Hereditary Autoinflammatory Diseases / Q000235:genetics / Q000276:immunology*; D006801:Humans; D011565:Psoriasis / Q000235:genetics / Q000276:immunology*
keywords: Autoinflammatory disease; Cytokines; Genetics; Immunopathogenesis; Inflammasome; Psoriasis; TH cells; TNF-α