title: Regulation of pqs quorum sensing via catabolite repression control in Pseudomonas aeruginosa.
abstract: Bacteria have evolved a set of regulatory pathways to adapt to the dynamic nutritional environment during the course of infection. However, the underlying mechanism of the regulatory effects by nutritional cues on bacterial pathogenesis is unclear. In the present study, we showed that the Pseudomonas aeruginosa catabolite repression control protein regulates the Pseudomonas quinolone signal quorum sensing, which further controls synthesis of virulence factor pyocyanin, biofilm formation and survival during infection models. Our study suggests that deregulation of the catabolite repression by P. aeruginosa might enhance its fitness during cystic fibrosis infections.
authors.affiliation: China-Japan Union Hospital, Jilin University, Changchun 130033, People's Republic of China.
authors.forename: Lianbo
authors.initials: L
authors.lastname: Zhang
authors.affiliation: China-Japan Union Hospital, Jilin University, Changchun 130033, People's Republic of China.
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Gao
authors.affiliation: China-Japan Union Hospital, Jilin University, Changchun 130033, People's Republic of China.
authors.forename: Wanying
authors.initials: W
authors.lastname: Chen
authors.affiliation: China-Japan Union Hospital, Jilin University, Changchun 130033, People's Republic of China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen 2100, Denmark.
authors.forename: Wang
authors.initials: W
authors.lastname: Hengzhuang
authors.affiliation: Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University 637551, Republic of Singapore.
authors.forename: Yicai
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Biological Sciences (SBS), Nanyang Technological University 637551, Republic of Singapore.|Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University 637551, Republic of Singapore.
authors.forename: Liang
authors.initials: L
authors.lastname: Yang
authors.affiliation: China-Japan Union Hospital, Jilin University, Changchun 130033, People's Republic of China.
authors.forename: Guang
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms; D057465:Catabolite Repression; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000502:physiology*; D011710:Pyocyanine / Q000235:genetics / Q000378:metabolism; D015363:Quinolones / Q000378:metabolism*; D053038:Quorum Sensing; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D015363:Quinolones; D012097:Repressor Proteins; D037521:Virulence Factors; C101896:crc protein, Pseudomonas; D011710:Pyocyanine