title: Interleukin-13 +1923C/T polymorphism is associated with asthma risk: a meta-analysis.
abstract: There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma. We performed this study to assess the association by the method of meta-analysis. A systematic search current to October 16, 2012, was conducted using PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) and identified ten studies comprising 13698 cases and 38209 controls. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. There was a significant association between IL-13 +1923C/T polymorphism and asthma risk in codominant model. When stratified by ethnicity, IL-13 +1923C/T polymorphism remained significantly associated with higher asthma risk in Asians and Caucasians. In the subgroup analysis by study quality, a significantly increased asthma risk was observed in high quality studies. Sensitivity analysis and cumulative analysis further strengthened the validity of the results. No publication bias was found in this meta-analysis. In conclusion, results from this meta-analysis suggested that IL-13 +1923C/T polymorphism was a risk factor of asthma.
authors.affiliation: Department of Intensive Care Medicine, No. 411 Hospital of PLA, Shanghai 200080, China.
authors.forename: Yongan
authors.initials: Y
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Nie
authors.forename: Guoxiang
authors.initials: G
authors.lastname: Lai
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Xiu
mesh_terms: D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000235:genetics* / Q000473:pathology; D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D018793:Interleukin-13