title: Appropriateness of surgical antimicrobial prophylaxis in the Latium region of Italy, 2008: a multicenter study.
abstract: BACKGROUND
  There is still wide variability in surgical antimicrobial prophylaxis (SAP) practice by different surgical teams and specialties, with potential impact on adverse events and the emergence of antibiotic resistance.
  
  
  METHODS
  We assessed SAP appropriateness in a regional prospective multicenter study on the basis of the agreement of the Surgical Care Improvement Project indicators (SCIP-Inf) with Italian guidelines (GL).
  
  
  RESULTS
  Prophylaxis was administered in 2,664 of 2,835 procedures (94%): In 2,346 of 2,468 (95%) as indicated and in 318 of 367 (86.6%) in which they were not indicated. The SCIP-Inf1 (timing), SCIP-Inf2 (antibiotic choice), and SCIP-Inf3 (duration) were in agreement with GL in 1,172 (50%), 1,983 (84.5%), and 1,121 (48%) of 2,346 procedures, respectively.
  
  
  CONCLUSIONS
  These results suggest the need for implementation of an antimicrobial stewardship program in this surgical setting.
authors.affiliation: Epidemiology Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy. silvia.pittalis@inmi.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Pittalis
authors.forename: Federica
authors.initials: F
authors.lastname: Ferraro
authors.forename: Pierluca
authors.initials: P
authors.lastname: Piselli
authors.forename: Luca Enrico
authors.initials: LE
authors.lastname: Ruscitti
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Grilli
authors.forename: Simone
authors.initials: S
authors.lastname: Lanini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ippolito
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Puro
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D017410:Practice Guidelines as Topic; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents