title: The efficacy of an experimental dentifrice containing 0.454% w/w stannous fluoride in providing relief from the pain of dentin hypersensitivity: an 8-week clinical study.
abstract: OBJECTIVE
  To compare the efficacy of a 0.454% w/w stannous fluoride containing anhydrous dentifrice and a negative control dentifrice containing 1,000 ppm fluoride (as sodium monofluorophosphate) at reducing dentin hypersensitivity over an 8-week period, following twice daily brushing.
  
  
  METHODS
  This was a randomized, examiner blind, two-treatment arm, stratified (by maximum baseline Schiff sensitivity score), parallel design, single-site study in 118 subjects, who had at least two sensitive teeth, and met all the criteria at the screening and baseline visit. The study was conducted in Las Vegas, NV, USA. Tactile threshold (Yeaple Probe) and evaporative (air-blast) sensitivity (with Schiff sensitivity scale) were employed as clinical measures to compare the efficacy of the test dentifrice containing 0.454% w/w stannous fluoride to the negative control (Colgate Cavity Protection) at reducing sensitivity at Weeks 4 and 8.
  
  
  RESULTS
  117 subjects completed the clinical study. At the 4- and 8-week time points, between treatment analyses demonstrated the test dentifrice to be significantly better at relieving subjects' sensitivity, for both validated clinical measures, compared to the negative control (at 4 weeks Schiff P < 0.0001 tactile threshold P < 0.0001; at 8 weeks Schiff P < 0.0001; tactile threshold P < 0.0001).
authors.affiliation: GlaxoSmithKline Consumer Healthcare, St Georges Avenue, Weybridge, KT13 ODE United Kingdom. charles.x.parkinson@gsk.com
authors.forename: Charles
authors.initials: C
authors.lastname: Parkinson
authors.forename: Nathan
authors.initials: N
authors.lastname: Hughes
authors.forename: Peter
authors.initials: P
authors.lastname: Jeffery
authors.forename: Ritika
authors.initials: R
authors.lastname: Jain
authors.forename: Liam
authors.initials: L
authors.lastname: Kennedy
authors.forename: Jimmy
authors.initials: J
authors.lastname: Qaqish
authors.forename: John T
authors.initials: JT
authors.lastname: Gallob
authors.forename: Stephen
authors.initials: S
authors.lastname: Mason
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003802:Dentifrices / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000517:prevention & control*; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000627:therapeutic use; D012449:Safety; D012684:Sensory Thresholds; D016037:Single-Blind Method; D014002:Tin Fluorides / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D003802:Dentifrices; D010710:Phosphates; D014002:Tin Fluorides; C012980:fluorophosphate; D005459:Fluorides