title: Resistant hypertension.
abstract: A 53 year old woman with hypercholesterolemia treated with statins, with no history of cardiovascular disease, was referred to the Hypertension and Vascular Risk Unit for management of hypertension resistant to 4 antihypertensive agents at full doses. The patient had obesity, with a body mass index of 36.3kg/m(2) and office blood pressure 162/102mm Hg. Physical examination showed no data of interest.
  
  
  METHODS
  glucose 120mg/dl, glycated Hb: 6.4%, albuminuria 68mg/g, kidney function and study of the renin angiotensin system and other biochemical parameters were normal. Echocardiography: left ventricular mass, 131g/m(2) (normal, <110g/m(2)). True resistant hypertension was confirmed by ambulatory monitoring of blood pressure during 24h (153/89mm Hg). Spironolactone treatment (25mg/day) was added and was well tolerated, with no change in renal function and kaliemia within normal (4.1mmol/l) following the treatment. After 8 weeks, blood pressure was well controlled: office blood pressure 132/86mm Hg and 24h-ambulatory blood pressure: 128/79mm Hg.
authors.affiliation: Unidad de HTA y Riesgo Vascular, Área de Enfermedades Cardiovasculares, Hospital Moisés Broggi (Sant Joan Despi/Hospitalet), Universidad de Barcelona, España. Electronic address: parmario@csi.cat.
authors.forename: P
authors.initials: P
authors.lastname: Armario
authors.forename: A
authors.initials: A
authors.lastname: Oliveras
authors.forename: A
authors.initials: A
authors.lastname: de la Sierra
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D013148:Spironolactone / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D013148:Spironolactone
keywords: Ambulatory monitoring of blood pressure; Hipercolesterolemia; Hipertensión arterial; Hypercholesterolemia; Hypertension; Monitorización ambulatoria de la presión arterial