title: Canine and feline dermatophytosis due to Microsporum gypseum: a retrospective study of clinical data and therapy outcome with griseofulvin.
abstract: OBJECTIVE
  Microsporum gypseum is a common inhabitant of the soil, occasionally responsible for human and animal ringworm. Few reports describe the treatment of dermatologic diseases due to M. gypseum. The objective of this study was to evaluate retrospectively cases of M. gypseum infection in dogs and cats.
  
  
  METHODS
  The occurrence of infection by this dermatophyte was retrospectively evaluated in dermatological specimens from 15,684 dogs and cats dermatologically diseased from Italy. Clinical outcome after treatment with griseofulvin combined with topical enilconazole was evaluated in 41 dogs and, out of label, 10 cats. Furthermore, in vitro susceptibility to griseofulvin and enilconazole was evaluated on 31 clinical isolates of M. gypseum.
  
  
  RESULTS
  One hundred and eighty-five specimens out of 15,684 (1.1%) scored positive for M. gypseum. The treatment failed to achieve both mycological and clinical cure in 16 dogs (39%) and four cats (40%), as well as fungal isolates demonstrated a very poor in vitro sensitivity when tested versus griseofulvin: the MIC value was 150 μg/mL. The ED50 value was calculated at 66 μg/mL.
  
  
  CONCLUSIONS
  Blind treatments with griseofulvin in ringworm due to M. gypseum should be avoided.
authors.affiliation: Dipartimento di Scienze Veterinarie, Università di Pisa, Viale delle Piagge 2, 4 Pisa, Italy. snardoni@vet.unipi.it
authors.forename: S
authors.initials: S
authors.lastname: Nardoni
authors.forename: L
authors.initials: L
authors.lastname: Mugnaini
authors.forename: R
authors.initials: R
authors.lastname: Papini
authors.forename: M
authors.initials: M
authors.lastname: Fiaschi
authors.forename: F
authors.initials: F
authors.lastname: Mancianti
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D004285:Dogs; D006118:Griseofulvin / Q000627:therapeutic use*; D008864:Microsporum / Q000502:physiology; D012189:Retrospective Studies; D014005:Tinea / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D006118:Griseofulvin
keywords: Animals; Animaux; Griseofulvin; Griséofulvine; In vitro susceptibility; In vivo treatment; Microsporum gypseum; Sensibilité in vitro; Traitement in vivo