title: Correlation between prediabetes conditions and microalbuminuria.
abstract: BACKGROUND
  Impaired fasting glucose (IFG), and impaired glucose tolerance (IGT) are two prediabetes conditions which have some correlation with macrovascular disorders. The risk of microvascular complications in these groups is not clear.
  
  
  OBJECTIVE
  The prevalence of albuminuria in subjects with IFG and IGT was evaluated in the present study.
  
  
  METHODS
  In this study three groups of subjects were entered (45 subjects in each group): IFG, IGT, and normal glucose tolerance as control. The urine albumin-creatinine ratio was studied in morning spot urine samples to detect microalbuminuria. The subjects were followed up for two years, and blood sugar and urine albumin and glycosylated hemoglobin (HbA1C) were measured every 6 months.
  
  
  RESULTS
  The prevalence rate of microalbuminuria was 15.5% in the prediabetic groups, while no one had microalbuminuria in the control group (P = 0.005). The prevalence of microalbuminuria in patients with IFG or IGT was not significantly different (17.8% vs. 13.3%) (P = 0.4). Fourteen subjects (4 in IFG group and 10 in IGT group) developed diabetes mellitus within a 2-year follow-up period (P = 0.1). Thirty six percent of subjects with albuminuria, and twelve percent of subjects without albuminuria progressed to diabetes mellitus during a 2-year follow-up (P = 0.02, odd ratio = 4.1; CI95%, 1.13-15.1).
  
  
  CONCLUSIONS
  The risk of microalbuminuria in prediabetic subjects is high, and probably prediabetic subjects are at higher risk of progression to diabetes mellitus. We suggest periodically evaluation of albuminuria in prediabetic patients after the diagnosis.
authors.affiliation: Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Adele
authors.initials: A
authors.lastname: Bahar
authors.forename: Atieh
authors.initials: A
authors.lastname: Makhlough
authors.forename: Atefe
authors.initials: A
authors.lastname: Yousefi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Kashi
authors.forename: Saeid
authors.initials: S
authors.lastname: Abediankenari
keywords: Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glucose Tolerance