title: The sequence signature of an Ig-fold.
abstract: Ig superfamily (IgSF) constitutes the largest superfamily in human genome. In particular, Ig-like domains are the most abundant structural module within cell surface receptors, functioning in nervous as well as immune system. Here I describe some key sequence signature of an I-set Ig-like domain from known structures of IgSF members. These signature residues define the I-set Ig-like domain, which should aid structural and functional studies of cell surface receptors.
authors.affiliation: Dana-Farber Cancer Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA. jwang@red.dfci.harvard.edu
authors.forename: Jia-Huai
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D006860:Hydrogen Bonding; D007136:Immunoglobulins / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D017510:Protein Folding; D017434:Protein Structure, Tertiary
chemical_list: D007136:Immunoglobulins