title: Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span.
abstract: Through its antioxidant, anticarcinogenic, and anti-inflammatory properties, resveratrol has become a candidate for drug development in the context of aging studies. Scientific evidence has highlighted its potential as a therapeutic agent for cardiovascular diseases and some cancers but also as an antiaging molecule. Resveratrol is thought to mimic the beneficial effects of chronic and moderate calorie restriction. Nevertheless, no study has demonstrated the prolongation of life span in healthy nonobese mammal models. This review summarizes recent findings on the effects of resveratrol on aging and life span in mammals. In our opinion, more studies should be performed to assess the effects of a chronic dietary intake of resveratrol in long-lived species close to humans, such as nonhuman primates. This will certainly generate more evidence about the ability of resveratrol to achieve the physiological benefits that have been observed in small mammal laboratory models and feature the eventual unwanted secondary effects that may occur under high levels of resveratrol.
authors.affiliation: UMR 7179 Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Brunoy, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Marchal
authors.forename: Fabien
authors.initials: F
authors.lastname: Pifferi
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D008136:Longevity / Q000187:drug effects* / Q000502:physiology; D008322:Mammals; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D013267:Stilbenes; D000077185:Resveratrol
keywords: antiaging strategy; life span; mimetic effect; nutrition; resveratrol