title: Modified Glasgow prognostic score in patients with incurable stage IV colorectal cancer.
abstract: BACKGROUND
  The modified Glasgow prognostic score is an inflammation-based prognostic score. This study examined whether this score, measured before surgical procedures, could predict postoperative cancer-specific survival.
  
  
  METHODS
  We retrospectively studied 79 colorectal cancer patients who underwent a surgical procedure for incurable stage IV disease. The modified Glasgow prognostic score (0 to 2) comprises C-reactive protein (≤10 vs >10 mg/L) and albumin (<35 vs ≥35 g/L) measurements.
  
  
  RESULTS
  In terms of overall survival, univariate analysis revealed significant differences in the status of lung metastasis, peritoneal dissemination, distant metastasis, hemoglobin, C-reactive protein, albumin, tumor resection, adjuvant chemotherapy, and modified Glasgow prognostic score. Multivariate analysis revealed that hemoglobin (P = .019), adjuvant chemotherapy (P = .002), and modified Glasgow prognostic score (0 and 1, low; 2, high) (P = .0001) were significant predictive factors for postoperative mortality.
  
  
  CONCLUSIONS
  The modified Glasgow prognostic score is simple to obtain and useful in predicting survival in incurable stage IV colorectal cancer patients undergoing surgery.
authors.affiliation: Department of Surgery, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka City, Tokyo, Japan. kishikitomokazu@yahoo.co.jp
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Kishiki
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Masaki
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Matsuoka
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Nobutsugu
authors.initials: N
authors.lastname: Abe
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Mori
authors.forename: Masanori
authors.initials: M
authors.lastname: Sugiyama
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D006454:Hemoglobins
keywords: Colorectal cancer; Glasgow prognostic score; Inflammation-based prognostic score; Stage IV