title: The effect of polymer degradation time on functional outcomes of temporary elastic patch support in ischemic cardiomyopathy.
abstract: Biodegradable polyurethane patches have been applied as temporary mechanical supports to positively alter the remodeling and functional loss following myocardial infarction. How long such materials need to remain in place is unclear. Our objective was to compare the efficacy of porous onlay support patches made from one of three types of biodegradable polyurethane with relatively fast (poly(ester urethane)urea; PEUU), moderate (poly(ester carbonate urethane)urea; PECUU), and slow (poly(carbonate urethane)urea; PCUU) degradation rates in a rat model of ischemic cardiomyopathy. Microporous PEUU, PECUU or PCUU (n = 10 each) patches were implanted over left ventricular lesions 2 wk following myocardial infarction in rat hearts. Infarcted rats without patching and age-matched healthy rats (n = 10 each) were controls. Echocardiography was performed every 4 wk up to 16 wk, at which time hemodynamic and histological assessments were performed. The end-diastolic area for the PEUU group at 12 and 16 wk was significantly larger than for the PECUU or PCUU groups. Histological analysis demonstrated greater vascular density in the infarct region for the PECUU or PCUU versus PEUU group at 16 wk. Improved left ventricular contractility and diastolic performance in the PECUU group was observed at 16 wk compared to infarction controls. The results indicate that the degradation rate of an applied elastic patch influences the functional benefits associated patch placement, with a moderately slow degrading PECUU patch providing improved outcomes.
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Hashizume
authors.forename: Yi
authors.initials: Y
authors.lastname: Hong
authors.forename: Keisuke
authors.initials: K
authors.lastname: Takanari
authors.forename: Kazuro L
authors.initials: KL
authors.lastname: Fujimoto
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Tobita
authors.forename: William R
authors.initials: WR
authors.lastname: Wagner
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D002404:Catheterization; D003094:Collagen / Q000378:metabolism; D004548:Elasticity / Q000187:drug effects*; D004549:Elastin / Q000378:metabolism; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D011140:Polyurethanes / Q000494:pharmacology*; D019919:Prosthesis Implantation; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors; D054457:Tissue Scaffolds / Q000737:chemistry; D014463:Ultrasonography
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes; D003094:Collagen; D004549:Elastin
keywords: Biodegradation; Elastomer; Heart; Polycarbonate; Polyurethane; Scaffold