title: Skin connective tissue and ageing.
abstract: Collagen atrophy is a major factor in skin ageing. A strong correlation exists between skin collagen loss and oestrogen deficiency caused by the menopause. Skin ageing is associated with a progressive increase in extensibility and a reduction in elasticity. With increasing age, the skin also becomes more fragile and susceptible to trauma, leading to more lacerations and bruising. Furthermore, wound healing is impaired in older women. Oestrogen use after the menopause increases collagen content, dermal thickness and elasticity, and it decreases the likelihood of senile dry skin. Large-scale clinical trials are necessary to help make informed recommendations about postmenopausal oestrogen use and its role in preventing skin ageing.
authors.affiliation: Department of Obstetrics and Gynaecology, Mater Dei Hospital, Msida MSD 2090, Malta. Electronic address: jean.calleja-agius@um.edu.mt.
authors.forename: Jean
authors.initials: J
authors.lastname: Calleja-Agius
authors.forename: Mark
authors.initials: M
authors.lastname: Brincat
authors.forename: Marika
authors.initials: M
authors.lastname: Borg
mesh_terms: D000375:Aging / Q000502:physiology*; D001284:Atrophy / Q000209:etiology; D003094:Collagen / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism / Q000473:pathology*; D004548:Elasticity; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D006801:Humans; D008593:Menopause / Q000502:physiology*; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D015595:Skin Aging / Q000473:pathology / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
chemical_list: D004967:Estrogens; D003094:Collagen
keywords: collagen; menopause; oestrogen; skin