title: [Alteration of biological rhythms causes metabolic diseases and obesity].
abstract: The incidence of obesity worldwide has become a serious, constantly growing public health issue that reaches alarming proportions in some countries. To date none of the strategies developed to combat obesity have proved to be decisive, and hence there is an urgent need to address the problem with new approaches. Today, studies in the field of chronobiology have shown that our physiology continually adapts itself to the cyclical changes in the environment, regard-less of whether they are daily or seasonal. This is possible thanks to the existence of a biological clock in our hypothalamus which regulates the expression and/or activity of enzymes and hormones involved in regulating our metabolism, as well as all the homeostatic functions. It has been observed that this clock can be upset as a result of today's modern lifestyle, which involves a drop in physical activity during the day and the abundant ingestion of food during the night, among other factors, which together promote metabolic syndrome and obesity. Hence, the aim of this review is to summarise the recent findings that show the effect that altering the circadian rhythms has on the metabolism and how this can play a part in the development of metabolic diseases.
authors.affiliation: Facultad de Ciencias, Universidad Autonoma de San Luis Potosi, San Luis de Potosi, Mexico.
authors.forename: Nadia
authors.initials: N
authors.lastname: Saderi
authors.forename: Carolina
authors.initials: C
authors.lastname: Escobar
authors.forename: Roberto
authors.initials: R
authors.lastname: Salgado-Delgado
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D021081:Chronobiology Disorders / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D004195:Disease Models, Animal; D005247:Feeding Behavior / Q000502:physiology; D005786:Gene Expression Regulation / Q000528:radiation effects; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D015994:Incidence; D008019:Life Style; D008027:Light; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D051379:Mice; D009765:Obesity / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D051381:Rats; D012636:Secretory Rate; D020178:Sleep Disorders, Circadian Rhythm / Q000209:etiology / Q000503:physiopathology; D014940:Work Schedule Tolerance
chemical_list: D056925:Circadian Rhythm Signaling Peptides and Proteins; D006728:Hormones; D005947:Glucose