title: Synthesis and asymmetric resolution of α-azido-peroxides.
abstract: An unprecedented synthesis of α-azido-peroxides has been developed using an FeCl3-catalyst starting from carbonyl, TMS-azide, and hydroperoxide. Further, a base promoted decomposition of synthesized secondary α-azido-peroxides to provide the corresponding tert-butyl esters has been disclosed. Finally, an asymmetric kinetic resolution of such α-azido-peroxides has also been developed to provide chiral α-azido-peroxides in excellent enantiopurity.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal-462023, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Pramanik
authors.forename: Prasanta
authors.initials: P
authors.lastname: Ghorai
mesh_terms: D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D010545:Peroxides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001386:Azides; D002712:Chlorides; D005290:Ferric Compounds; D010545:Peroxides; D006861:Hydrogen Peroxide; C024555:ferric chloride