title: Antifungal effects of palmitic acid salt and ultrapure soft water on Scedosporium apiospermum.
abstract: OBJECTIVE
  Scedosporium apiospermum sometimes causes serious infectious diseases on the skin of immunodeficient subjects. Antifungal effects of fatty acid salts in soap against S. apiospermum were investigated under different water conditions.
  
  
  RESULTS
  Ultrapure soft water (UPSW) was generated by the water softener with cation-exchange resin. The calcium and magnesium ions were replaced with sodium ions in UPSW. Scedosporium apiospermum was incubated with different fatty acid salts that constituted soap in distilled water (DW), tap water (TW) and UPSW. After incubation, the number of fungi was counted. Among the fatty acids, palmitic acid salt (C16) reduced the number of S. apiospermum. UPSW enhanced the antifungal effect of C16 on S. apiospermum. The absence of both calcium and magnesium ions and the existence of sodium chloride in UPSW were responsible for its antifungal effect. In addition, repeated short-term treatment with UPSW and C16 decreased the number of S. apiospermum.
  
  
  CONCLUSIONS
  Antifungal effects of C16 on S. apiospermum were demonstrated. Moreover, the use of UPSW promoted the antifungal effect of C16.
  
  
  CONCLUSIONS
  This study provides the preventive method for diseases associated with S. apiospermum infection using novel palmitic acid soap in UPSW.
authors.affiliation: Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Jung
authors.forename: M
authors.initials: M
authors.lastname: Miyagawa
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Amagai
authors.forename: K
authors.initials: K
authors.lastname: Oida
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
authors.forename: M
authors.initials: M
authors.lastname: Takai
authors.forename: S
authors.initials: S
authors.lastname: Nishikawa
authors.forename: H
authors.initials: H
authors.lastname: Jang
authors.forename: S
authors.initials: S
authors.lastname: Ishizaka
authors.forename: G
authors.initials: G
authors.lastname: Ahn
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D019308:Palmitic Acid / Q000494:pharmacology*; D012492:Salts / Q000494:pharmacology; D021681:Scedosporium / Q000187:drug effects*; D012915:Soaps / Q000737:chemistry; D012965:Sodium Chloride / Q000494:pharmacology; D014867:Water / Q000737:chemistry / Q000494:pharmacology*; D018508:Water Purification; D014880:Water Softening
chemical_list: D000935:Antifungal Agents; D012492:Salts; D012915:Soaps; D014867:Water; D019308:Palmitic Acid; D012965:Sodium Chloride
keywords: fungi; palmitic acid; soap; soft water