title: Slowing the aging process.
abstract: Research into the aging process is very new. For many years aging was thought to be the natural and inevitable consequence of a life of wear and tear. The idea that aging could be influenced by the genetic code and had a modifiable biologic component is less than 20 years old. During this time, aging has come to be understood as a complex biologic process controlled by signaling pathways and transcription factors. Similar attitudes pervade the field of nephrology. Whether a decline in renal function with age represents normal aging or kidney disease is the subject of much debate.
authors.affiliation: Division of Geriatrics, Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. wiggi@umich.edu
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Wiggins
authors.forename: Markus
authors.initials: M
authors.lastname: Bitzer
mesh_terms: D000368:Aged; D000818:Animals; D031204:Caloric Restriction / Q000379:methods; D004249:DNA Damage; D057890:Epigenomics / Q000379:methods; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000235:genetics*; D009399:Nephrons / Q000502:physiology; D051436:Renal Insufficiency, Chronic / Q000517:prevention & control*; D015398:Signal Transduction / Q000235:genetics*; D016615:Telomere
keywords: Aging; Cellular processes; Chronic kidney disease; Genetic pathways