title: Subacute cutaneous lupus erythematosus induced by chemotherapy: gemcitabine as a causative agent.
abstract: OBJECTIVE
  Several chemotherapeutic agents have been reported to induce subacute cutaneous lupus erythematosus (SCLE). To our knowledge, this is the first report to date of SCLE induced by monotherapeutic gemcitabine hydrochloride and includes a comprehensive review of all published cases of chemotherapeutic drug-induced SCLE.
  
  
  METHODS
  We describe a patient who developed a SCLE-like eruption after being administered gemcitabine and discuss 16 other published cases of chemotherapeutic drug-induced SCLE.
  
  
  CONCLUSIONS
  This case and a review of the literature call attention to gemcitabine and other chemotherapeutic agents that have been reported to cause drug-induced SCLE. We also discuss the clinical features of the disease.
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Wiznia
authors.forename: Antonio
authors.initials: A
authors.lastname: Subtil
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Choi
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000473:pathology; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003841:Deoxycytidine; D000093542:Gemcitabine