title: [Effect of Dingguier umbilical paste on rats with functional dyspepsia and mice with splenic asthenia].
abstract: OBJECTIVE
  To observe the effect of Dingguier umbilical paste on rats with functional dyspepsia and mice with splenic asthenia, and investigate the related mechanism.
  
  
  METHODS
  Functional dyspepsia models of rats were made by irregular food intake plus diluted hydrochloric acid. Successional treatments were offered for 14 days. The rats weights, contents of serum NO, AChE and MC were measured. The rats with splenic asthenia were made by rhubarb feed, and observed the affection of gastric emptying.
  
  
  RESULTS
  Compared with those in the model control group, the weight of rats in all dosages Dingguier umbilical paste groups increased obviously (P < 0.05), pepsin activity of rats in the dosage (1.34 g x kg(-1)) Dingguier umbilical paste groups was significantly higher and the contents of NO and quantities of MC in the dosage (2.67 g x kg(-1)) Dingguier umbilical paste groups decreased clearly (P < 0.05), and the contents of serum AChE in all dosages Dingguier umbilical paste groups rose apparently. The weight of mice with splenic asthenia increased obviously, accelerated gastric emptying, and improved the symptom.
  
  
  CONCLUSIONS
  Dingguier umbilical paste has significant improvement of indigestion. The related mechanism may be to reduce the content of serum NO and the quantity of MC and enhance the content of serum AChE.
authors.affiliation: Department of Pharmacy, First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Ma
authors.forename: Si-Jun
authors.initials: SJ
authors.lastname: Zhao
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wang
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Piao
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Wang
mesh_terms: D000818:Animals; D001247:Asthenia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D001835:Body Weight / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004415:Dyspepsia / Q000188:drug therapy* / Q000503:physiopathology; D004435:Eating / Q000187:drug effects; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D014472:Umbilicus
chemical_list: D004365:Drugs, Chinese Herbal