title: Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy?
abstract: This chapter briefly summarizes the most important processes by which hypoxia, lactate accumulation, and acidosis may influence malignant progression and therapeutic resistance of solid malignant tumors. While these phenomena are often elements of an integrated reaction, they may occur independently of each other under certain circumstances. The latter information may be of interest with regard to possible "targeted" therapeutic interventions.
authors.affiliation: Department of Radiooncology and Radiotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. arnmayer@uni-mainz.de.
authors.forename: Arnulf
authors.initials: A
authors.lastname: Mayer
authors.affiliation: Department of Radiooncology and Radiotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Vaupel
mesh_terms: D000138:Acidosis / Q000473:pathology; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D006801:Humans; D000860:Hypoxia / Q000378:metabolism* / Q000473:pathology; D019344:Lactic Acid / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology
chemical_list: D019344:Lactic Acid