title: DNA repair gene XRCC3 Thr241Met polymorphism and glioma risk: a meta-analysis.
abstract: BACKGROUND
  The polymorphism of XRCC3 Thr241Met has been indicated to be correlated with glioma susceptibility, but study results are still debatable. The present meta-analysis was performed to investigate the association between XRCC3 Thr241Met polymorphism and glioma.
  
  
  METHODS
  A total of 3754 glioma patients and 4849 controls from nine separate studies were involved. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) was assessed by the random-effects model.
  
  
  RESULTS
  The association between XRCC3 Thr241Met polymorphism and glioma was significant in the recessive model (OR = 1.36; 95% CI, 1.02 - 1.82; P = 0.03). In a stratified analysis by the ethnicity, significantly increased risk was detected in Asians (OR = 1.93; 95% CI, 1.18 - 3.17; P = 0.009).
  
  
  CONCLUSIONS
  In conclusion, XRCC3 Thr241Met polymorphism was implied to be associated with increased glioma risk. More studies are needed to validate this result.
authors.affiliation: Department of Neurosurgery, CPLA No. 98 Hospital No. 9 Chezhan Road, Huzhou 313000, Zhejiang, China.
authors.forename: Bao
authors.initials: B
authors.lastname: Zhao
authors.forename: Jingliang
authors.initials: J
authors.lastname: Ye
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.forename: Guojun
authors.initials: G
authors.lastname: Su
authors.forename: Ruizhang
authors.initials: R
authors.lastname: Han
keywords: Glioma; XRCC3; meta-analysis; polymorphism