title: More than a simple storage organ: adipose tissue as a source of adipokines involved in cardiovascular disease.
abstract: Overweight and obesity in many countries have developed into a serious health problem by themselves and by their impact on other pathologies such as insulin resistance, type 2 diabetes, hypertension, heart disease and cancer. The modulation of these diseases by adipose tissue-derived biomolecules, so-called adipokines, could be the key to differentiate between metabolically healthy and unhealthy obesity. This review will discuss the pathophysiological role of selected adipokines, primarily focusing on cardiovascular diseases. Furthermore, we will highlight possible therapeutic approaches, which target these biomolecules.
authors.affiliation: Johann Wojta, Department of Internal Medicine II, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, Tel.: +43 1 40400 73500, Fax: +43 1 40400 73586, E-mail: johann.wojta@meduniwien.ac.at.
authors.forename: Gersina
authors.initials: G
authors.lastname: Rega-Kaun
authors.forename: Christoph
authors.initials: C
authors.lastname: Kaun
authors.forename: Johann
authors.initials: J
authors.lastname: Wojta
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D058990:Molecular Targeted Therapy; D009765:Obesity / Q000378:metabolism* / Q000473:pathology
chemical_list: D054392:Adipokines
keywords: Obesity; atherosclerosis; thrombosis