title: An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.
abstract: The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor mediates many biological processes. Herein, we investigated if 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE, an endogenous AhR ligand) regulated proliferation and migration of human ovarian cancer cells via AhR. We found that AhR was widely present in many histotypes of ovarian cancer tissues. ITE suppressed OVCAR-3 cell proliferation and SKOV-3 cell migration in vitro, which were blocked by AhR knockdown. ITE also suppressed OVCAR-3 cell growth in mice. These data suggest that the ITE might potentially be used for therapeutic intervention for at least a subset of human ovarian cancer.
authors.affiliation: Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, PR China.|Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI 53715, United States.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI 53715, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI 53715, United States.
authors.forename: Yi-Zhou
authors.initials: YZ
authors.lastname: Jiang
authors.affiliation: Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI 53715, United States.|Qilu Hospital of Shandong University, Jinan 250012, Shandong, PR China.
authors.forename: Cai-Feng
authors.initials: CF
authors.lastname: Dai
authors.affiliation: Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI 53715, United States.
authors.forename: Manish S
authors.initials: MS
authors.lastname: Patankar
authors.affiliation: AhR Pharmaceuticals, Inc., Madison, WI 53719, United States.
authors.forename: Jia-Sheng
authors.initials: JS
authors.lastname: Song
authors.affiliation: Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI 53715, United States.|Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008024:Ligands; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics / Q000378:metabolism*; D013844:Thiazoles / Q000494:pharmacology*; D046888:Tissue Array Analysis; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: C548651:2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester; D000970:Antineoplastic Agents; D007211:Indoles; D008024:Ligands; D018336:Receptors, Aryl Hydrocarbon; D013844:Thiazoles; C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1
keywords: Aryl hydrocarbon receptor; Growth; ITE; Ovarian cancer cells