title: Clinical features and survival outcomes of patients with diffuse large B-cell lymphoma: analysis of web-based data from the Korean Lymphoma Working Party Registry.
abstract: BACKGROUND
  This study aimed to survey the clinical spectrum of diffuse large B-cell lymphoma (DLBCL) in terms of epidemiology, pathologic subtypes, stage, and prognostic index as well as treatment outcomes.
  
  
  METHODS
  In 2007-2008, 13 university hospitals evenly distributed in the Korean peninsula contributed to the online registry of DLBCL at www.lymphoma.or.kr and filed a total of 1,665 cases of DLBCL recorded since 1990.
  
  
  RESULTS
  Our analysis showed a higher prevalence of DLBCL in male than in female individuals (M:F=958:707), and extranodal disease was more common than primary nodular disease (53% vs. 47%). Among the 1,544 patients who had been treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) or rituximab-CHOP (R-CHOP) therapy with or without radiation, 993 (63.9%) were alive, with 80% free of disease, 417 were dead (26.8%), with 13% free of disease, and 144 (9.3%) were lost to follow-up, with 23% free of disease. Age below 60 years, stage at diagnosis, international prognostic index (IPI) score regardless of age, and addition of rituximab to CHOP therapy in low- and low-intermediate-risk groups according to IPI scores significantly increased survival duration.
  
  
  CONCLUSIONS
  The epidemiology, clinical spectrum, and biological behavior of DLBCL in Korea are similar to those observed in Western countries, and the advent of rituximab improved survival.
authors.affiliation: Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Korea. ; Korean Society of Hematology Lymphoma Working Party, Korea.
authors.forename: Hyeon Gyu
authors.initials: HG
authors.lastname: Yi
authors.forename: Jin Seok
authors.initials: JS
authors.lastname: Kim
authors.forename: Cheolwon
authors.initials: C
authors.lastname: Suh
authors.forename: Won Seog
authors.initials: WS
authors.lastname: Kim
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Kwak
authors.forename: Jong-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Yang Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Young Don
authors.initials: YD
authors.lastname: Joo
authors.forename: Yoo Hong
authors.initials: YH
authors.lastname: Min
authors.forename: Hong Ghi
authors.initials: HG
authors.lastname: Lee
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Yoon
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Won
authors.forename: Seonyang
authors.initials: S
authors.lastname: Park
authors.forename: Hugh Chul
authors.initials: HC
authors.lastname: Kim
authors.forename: Chul Soo
authors.initials: CS
authors.lastname: Kim
keywords: CHOP regimen; Diffuse large B-cell lymphoma; Epidemiology; Rituximab; Survival