title: Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP.
abstract: MicroRNA has been recently recognized as playing a prominent role in tumorigenesis and metastasis. Here, we report that miR-338-3p was epigenetically silenced in gastric cancer, and its down-regulation was significantly correlated with gastric cancer clinicopathological features. Strikingly, restoring miR-338-3p expression in SGC-7901 gastric cancer cells inhibited proliferation, migration, invasion and tumorigenicity in vitro and in vivo, at least partly through inducing apoptosis. Furthermore, we demonstrate the oncogene SSX2IP is a target of miR-338-3p. We propose that miR-338-3p functions as a tumor suppressor in gastric cancer, and the methylation status of its CpG island could serve as a potential diagnostic marker for gastric cancer.
authors.affiliation: Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Pu
authors.initials: P
authors.lastname: Li
authors.forename: Xuehua
authors.initials: X
authors.lastname: Chen
authors.forename: Liping
authors.initials: L
authors.lastname: Su
authors.forename: Chenglong
authors.initials: C
authors.lastname: Li
authors.forename: Qiaoming
authors.initials: Q
authors.lastname: Zhi
authors.forename: Beiqin
authors.initials: B
authors.lastname: Yu
authors.forename: Hong
authors.initials: H
authors.lastname: Sheng
authors.forename: Junqing
authors.initials: J
authors.lastname: Wang
authors.forename: Runhua
authors.initials: R
authors.lastname: Feng
authors.forename: Qu
authors.initials: Q
authors.lastname: Cai
authors.forename: Jianfang
authors.initials: J
authors.lastname: Li
authors.forename: Yingyan
authors.initials: Y
authors.lastname: Yu
authors.forename: Min
authors.initials: M
authors.lastname: Yan
authors.forename: Bingya
authors.initials: B
authors.lastname: Liu
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Zhu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000628:therapy*; D023041:Xenograft Model Antitumor Assays
chemical_list: C532050:MIRN338 microRNA, human; D035683:MicroRNAs; D009363:Neoplasm Proteins; D012097:Repressor Proteins; C093962:synovial sarcoma X breakpoint proteins