title: Anaphylactic reaction after the concomitant intravenous administration of corticosteroids and gastroprotective drugs: two case reports.
abstract: Corticosteroids are therapeutic drugs widely used in cases of allergic, inflammatory and autoimmune diseases, but sometimes allergic hypersensitivity reactions have been reported as a rare adverse effect of the corticosteroids themselves. Moreover, glucocorticoids can induce gastric lesions; thats why they are sometimes administered intravenously together with some drugs such as proton pump inhibitors (PPI) or inhibitors of histamine-2 receptors (antiH2) working as gastric protectors. Although it is difficult to establish which drug was responsible in case of hypersensitivity reactions, as hypersensitivity reactions following to the use of PPI or anti-H2 have been already described in literature. Here we describe two cases of immediate-type hypersensitivity triggered from the administration of a corticosteroid plus a gastroprotective agent and the diagnostic check up required in both these patients.
authors.forename: M T
authors.initials: MT
authors.lastname: Ventura
authors.forename: R
authors.initials: R
authors.lastname: Buquicchio
authors.forename: R
authors.initials: R
authors.lastname: Cecere
authors.forename: G
authors.initials: G
authors.lastname: Calogiuri
authors.forename: C D
authors.initials: CD
authors.lastname: Cannito
authors.forename: M
authors.initials: M
authors.lastname: De Donno
authors.forename: G
authors.initials: G
authors.lastname: Maietta
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis; D001491:Basophils / Q000502:physiology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006635:Histamine H2 Antagonists / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D012882:Skin Tests
chemical_list: D000305:Adrenal Cortex Hormones; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D009853:Omeprazole