title: Cancer, stem cell misplacement and cancer stem cells.
abstract: The cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM, Wang et al. challenged the conventional somatic genetic mutation model of multi-stage carcinogenesis of breast cancer and proposed that 'Invasive cancers are not necessary from preformed in situ tumours-an alternative way of carcinogenesis from misplaced stem cells'. If this stem cell misplacement theory could withstand future experimental evaluation, it may provide a paradigm shift in the prevention and management of cancer in the clinic.
authors.affiliation: Institute of Hepatitis and Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Center of Liver Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liao
mesh_terms: D063646:Carcinogenesis / Q000235:genetics / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology*; D013234:Stem Cells / Q000473:pathology*