title: Replenishable dendrimer-nanoparticle hybrid membranes for sustained release of therapeutics.
abstract: We report a versatile hybrid membrane for sustained release therapeutic delivery systems. Chemically-directed assembly of a hybrid membrane of nanoparticles and dendrimers was integrated with a fluidic delivery device and a refillable drug reservoir, providing continuous sustained release.
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003, USA.
authors.forename: Myoung-Hwan
authors.initials: MH
authors.lastname: Park
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Subinoy
authors.initials: S
authors.lastname: Rana
authors.forename: David
authors.initials: D
authors.lastname: Solfiell
authors.forename: Youngdo
authors.initials: Y
authors.lastname: Jeong
authors.forename: Bradley
authors.initials: B
authors.lastname: Duncan
authors.forename: Bo
authors.initials: B
authors.lastname: Yan
authors.forename: Büşra
authors.initials: B
authors.lastname: Aksoy
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry; D040761:Biomimetic Materials / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D004317:Doxorubicin; D000537:Aluminum Oxide