title: Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer.
abstract: The objective of the current study was to investigate the expression pattern and clinicopathological significance of MTA3 in patients with non-small cell lung cancer (NSCLC). The expression profile of MTA3 in NSCLC tissues and adjacent noncancerous lung tissues was detected by immunohistochemistry. MTA3 was overexpressed in 62 of 108 (57.4%) human lung cancer samples and correlated with p-TNM stage (p<0.0001), nodal metastasis (p = 0.0009) and poor prognosis (p<0.05). In addition, the depletion of MTA3 expression with small interfering RNAs inhibited cell growth and colony formation in the A549 and H157 lung cancer cell lines. Moreover, MTA3 depletion induced cell cycle arrest at the G1/S boundary. Western blotting analysis revealed that the knockdown of MTA3 decreased the protein levels of cyclin A, cyclin D1 and p-Rb. These results indicate that MTA3 plays an important role in NSCLC progression.
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Li
authors.forename: Liangliang
authors.initials: L
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.forename: Zixuan
authors.initials: Z
authors.lastname: Li
authors.forename: Wenting
authors.initials: W
authors.lastname: Luo
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Tang
authors.forename: Xueshan
authors.initials: X
authors.lastname: Qiu
authors.forename: Enhua
authors.initials: E
authors.lastname: Wang
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016213:Cyclins / Q000378:metabolism; D018450:Disease Progression; D015536:Down-Regulation; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008207:Lymphatic Metastasis; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D016213:Cyclins; C486657:MTA3 protein, human; D009363:Neoplasm Proteins