title: Improved network community structure improves function prediction.
abstract: We are overwhelmed by experimental data, and need better ways to understand large interaction datasets. While clustering related nodes in such networks-known as community detection-appears a promising approach, detecting such communities is computationally difficult. Further, how to best use such community information has not been determined. Here, within the context of protein function prediction, we address both issues. First, we apply a novel method that generates improved modularity solutions than the current state of the art. Second, we develop a better method to use this community information to predict proteins' functions. We discuss when and why this community information is important. Our results should be useful for two distinct scientific communities: first, those using various cost functions to detect community structure, where our new optimization approach will improve solutions, and second, those working to extract novel functional information about individual nodes from large interaction datasets.
authors.affiliation: School of Computational Sciences, Korea Institute for Advanced Study, Seoul, Korea. jlee@kias.re.kr
authors.forename: Juyong
authors.initials: J
authors.lastname: Lee
authors.forename: Steven P
authors.initials: SP
authors.lastname: Gross
authors.forename: Jooyoung
authors.initials: J
authors.lastname: Lee
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D008390:Markov Chains; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D008958:Models, Molecular; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D040901:Proteomics / Q000379:methods
chemical_list: D011506:Proteins