title: Advanced abdominal arterial calcification sparing kidney allograft--case report.
abstract: Excess and progressing arterial calcification is a frequent finding in patients with chronic kidney disease and in diabetics. Vascular calcification present in patients on dialysis, usually continues to progress (although possibly with slower rate) in patients after kidney transplantation. These observations are limited mostly to aorta and coronary arteries; virtually no data exist on progression in vascular calcification within the vasculature of transplanted kidney. The case report presents the patient with diabetes and non-functioning renal transplant back on dialysis with extremely severe intra-abdominal artery calcification, sparing renal artery of transplanted kidney. Calcification did not develop within transplanted kidney despite 10 years of exposition to diabetic environment and a few years of chronic kidney disease after transplantation, including CKD-T stage 5 for at least one year after re-starting of dialysis. To the best of our knowledge, this is the second report ever describing sparing of kidney graft from calcification despite disseminated calcification in other vascular beds. It is tempting to speculate that some "intrinsic" factors exist within the transplanted kidney that protects it from calcification despite exposure to procalcifying milieu of diabetes and uremia.
authors.affiliation: Department of Nephrology, Hypertension and Internal Medicine, Medical Faculty, University of Warmia and Mazury, Olsztyn, Poland. stompin@mp.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Stompór
authors.forename: Anna
authors.initials: A
authors.lastname: Pawłowska
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Kozielec
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Wasilewski
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Stefanowicz
mesh_terms: D000328:Adult; D064591:Allografts / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D000792:Angiography; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods; D009203:Myocardial Infarction / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D012077:Renal Artery / Q000000981:diagnostic imaging*; D006435:Renal Dialysis; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D061205:Vascular Calcification / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy