title: [Morphological study on early development of brain derived neurophic factor-positive neurons in the frontal lobe of human fetus].
abstract: OBJECTIVE
  To investigate the growth and development of brain derived neurophic factor(BDNF)-positive neurons in the frontal lobe of human fetus.
  
  
  METHODS
  The expression of the BDNF-positive neurons in the frontal lobe of human fetus in the 2(nd),3(rd),and 4(th) month of gestation were observed with the streptavidin-biotin-complex/immunoperoxidase(SABC)method.
  
  
  RESULTS
  By the second month of gestation,BDNF-positive neurons were seen in the subventricular layer of the frontal lobe of cerebellum.By the third month of gestation,BDNF-positive neurons in the central layer were in various shapes,with big nucleus,less cytoplasm,and small processes.By the fourth month of gestation,BDNF-positive neurons in the central layer grew larger in size,cytoplasm increased,the BDNF-positive expression was enhanced with deeper dyeing,and the nerve fibers and particles were distributed between neurons;also,the BDNF-positive neurons were seen in the marginal layer of the frontal lobe of cerebrum.
  
  
  CONCLUSIONS
  BDNF-positive neurons may participate in the early development of the frontal lobe of cerebrum of human fetus.
authors.affiliation: Department of Pathology,Wannan Medical College,Wuhu, Anhui, China.
authors.forename: Lan-rong
authors.initials: LR
authors.lastname: Zheng
authors.forename: Xiao-qun
authors.initials: XQ
authors.lastname: Zhu
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Huang
authors.forename: Qian
authors.initials: Q
authors.lastname: Gu
authors.forename: Dong-hui
authors.initials: DH
authors.lastname: Xie
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism*; D005625:Frontal Lobe / Q000196:embryology*; D006801:Humans; D009474:Neurons / Q000166:cytology* / Q000378:metabolism
chemical_list: D019208:Brain-Derived Neurotrophic Factor