title: Impact of reticular pseudodrusen on macular function.
abstract: OBJECTIVE
  To investigate the impact of reticular pseudodrusen on macular function using microperimetry.
  
  
  METHODS
  Eighteen consecutive patients (18 eyes) with reticular pseudodrusen (Group 1), and without medium/large drusen, underwent microperimetry. Eighteen age-matched and sex-matched subjects (18 eyes) with typical drusen and without pseudodrusen (Group 2) also underwent microperimetry. Macular sensitivity was assessed by microperimetry and compared between the two Groups.
  
  
  RESULTS
  Mean age of patients with reticular pseudodrusen and with typical drusen was 77.3 ± 6.8 years and 75.0 ± 9.9 years, respectively (P = 0.4), and 61.1% and 61.1% were women, respectively. Mean best-corrected visual acuity was 0.14 ± 0.09 logarithm of the minimum angle of resolution and 0.13 ± 0.09 logarithm of the minimum angle of resolution (P = 0.8) in Group 1 and Group 2, respectively. Microperimetry revealed a significant difference in overall mean macular sensitivity ("square 7 × 7"; 49 points) between Group 1 and Group 2 (5.9 ± 1.7 dB vs. 8.8 ± 2.4 dB, P < 0.001). Both mean central macular sensitivity ("square 3 × 3"; 9 points) and mean peripheral macular microperimetric sensitivity (overall "square 7 × 7" - central "square 3 × 3"; 40 points) were significantly reduced in Group 1 compared with Group 2 (central macular sensitivity: 6.9 ± 1.7 dB vs. 8.9 ± 2.6 dB in Group 1 and Group 2, respectively; P = 0.01; peripheral macular sensitivity: 5.7 ± 1.8 dB vs. 8.7 ± 2.3 dB in Group 1 and Group 2, respectively; P < 0.001). In Group 1, mean peripheral sensitivity was reduced when compared with mean central sensitivity (5.7 ± 1.8 dB vs. 6.9 ± 1.7 dB, P = 0.01), whereas in Group 2, mean sensitivity was similar in both peripheral and central macula (8.7 ± 2.3 dB vs. 8.9 ± 2.6 dB, P = 0.4).
  
  
  CONCLUSIONS
  Eyes with reticular pseudodrusen present a greater extent of reduced sensitivity than eyes with typical drusen.
authors.affiliation: *Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France; and †Department of Ophthalmology, Hospital San Raffaele, University Vita Salute San Raffaele, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: Nathalie
authors.initials: N
authors.lastname: Massamba
authors.forename: Mayer
authors.initials: M
authors.lastname: Srour
authors.forename: Elise
authors.initials: E
authors.lastname: Boulanger
authors.forename: Anouk
authors.initials: A
authors.lastname: Georges
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D000368:Aged; D020256:Choroidal Neovascularization / Q000503:physiopathology; D005260:Female; D005451:Fluorescein Angiography; D057092:Geographic Atrophy / Q000503:physiopathology; D006801:Humans; D008268:Macular Degeneration / Q000503:physiopathology*; D008297:Male; D018613:Microscopy, Confocal; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D015593:Retinal Drusen / Q000503:physiopathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology