title: Mucormycosis in Cairo, Egypt: review of 10 reported cases.
abstract: We report on 10 cases of mucormycosis, as defined by The European Organization for Research and Treatment of Cancer and Mycoses Study Group (EORTC/MSG) standards of invasive fungal diseases, among patients with a recent history of neutropenia, prolonged use of corticosteroids and treatment with immunosuppressants. They were all observed at the Ain Shams University Specialized Hospital in Cairo, Egypt, during the year 2010. These cases were categorized as 50% proven and 50% probable, with none considered to be possible mucormycosis. The median age of the patients discussed in this report was 50 years (range 22-68 years), of which 80% were male and 20% were female. Uncontrolled diabetes with ketoacidosis was noted in 60% of cases, while 40% of the patients had undergone liver transplantations. Pulmonary mucormycosis was the predominant presentation as it was noted in 80% of cases, but there was only 20% sinus involvement. Members of the genus Lichtheimia were the most common etiologic agents (40% of all cases), whereas Rhizopus ssp. were recovered from 30% of cases, Syncephalastrum spp. in 20%, and 10% of patients were infected with Rhizomucor. Liposomal formulation of amphotericin B (LAMB) was successfully used to treat all the cases described in this report. We concluded that the incidence of mucormycosis was relatively high during the study period in this one-center study and that additional studies looking into the diagnosis and the control of mucormycosis in Egypt are required.
authors.affiliation: Microbiology Department, Faculty of Science, University Specialized Hospital, Ain Shams University, Cairo, Egypt.
authors.forename: Sherif M
authors.initials: SM
authors.lastname: Zaki
authors.forename: Iman M
authors.initials: IM
authors.lastname: Elkholy
authors.forename: Nadia A
authors.initials: NA
authors.lastname: Elkady
authors.forename: Khayria
authors.initials: K
authors.lastname: Abdel-Ghany
mesh_terms: D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D048909:Diabetes Complications; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006761:Hospitals; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009090:Mucorales / Q000145:classification / Q000302:isolation & purification*; D009091:Mucormycosis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C068538:liposomal amphotericin B; D000666:Amphotericin B
keywords: Egypt; ITS1-5.8s-ITS2; epidemiology; mucormycosis