title: Label-free photoelectrochemical immunosensor based on CdTe/CdS co-sensitized TiO2 nanotube array structure for octachlorostyrene detection.
abstract: An octachlorostyrene (OCS) photoelectrochemical (PEC) immunosensor was developed by cross-linking anti-OCS antibody onto a CdTe/CdS-sensitized TiO2 nanotube arrays (NTAs). The anti-OCS polyclonal antibody was developed in rabbit as a result of immunization with BSA-OCS hapten conjugate. TiO2 NTAs were immobilized firstly with hydrothermally synthesized CdTe quantum dots (QDs), and then CdS which filled the spaces within the CdTe-TiO2 composite and encapsulated the CdTe QDs, forming an ideal stepwise bandedge structure, which benefited the light harvesting. The PEC immunosensor therefore shows high specificity and high sensitivity with a limit of detection of 2.58 pM, and a linear range from 5 pM to 50 nM. The testing time is 4 min. The analysis of river water reveals that the proposed sensor can be applied in the analysis of OCS in real water samples without complicated pre-treatments.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Cai
authors.forename: Pengtao
authors.initials: P
authors.lastname: Sheng
authors.forename: Liping
authors.initials: L
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Niya
authors.initials: N
authors.lastname: Wang
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Cai
mesh_terms: D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000295:instrumentation; D004784:Environmental Monitoring / Q000295:instrumentation; D004867:Equipment Design; D007118:Immunoassay / Q000295:instrumentation; D057230:Limit of Detection; D043942:Nanotubes / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry; D011817:Rabbits; D045483:Rivers / Q000737:chemistry; D013343:Styrenes / Q000032:analysis*; D013440:Sulfides / Q000737:chemistry*; D013691:Tellurium / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D019187:Cadmium Compounds; D013343:Styrenes; D013440:Sulfides; D014874:Water Pollutants, Chemical; C034939:cadmium sulfide; C009495:titanium dioxide; C014138:octachlorostyrene; D014025:Titanium; D013691:Tellurium; C028337:cadmium telluride
keywords: CdTe/CdS–TiO(2) NTAs; Label-free immunosensor; Octachlorostyrene; Photoelectrochemical