title: Catalytic Aminohalogenation of Alkenes and Alkynes.
abstract: Catalytic aminohalogenation methods enable the regio- and stereoselective vicinal difunctionalization of alkynes, allenes and alkenes with amine and halogen moieties. A range of protocols and reaction mechanisms including organometallic, Lewis base, Lewis acid and Brønsted acid catalysis have been disclosed, enabling the regio- and stereoselective synthesis of halogen-functionalized acyclic amines and nitrogen heterocycles. Recent advances including aminofluorination and catalytic enantioselective aminohalogenation reactions are summarized in this review.
authors.affiliation: Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York, USA.
authors.forename: Sherry R
authors.initials: SR
authors.lastname: Chemler
authors.forename: Michael T
authors.initials: MT
authors.lastname: Bovino
keywords: alkenes; alkynes; allenes; aminohalogenation; catalysis; enantioselelective; haloamidation; haloamines