title: Cerebral venous thrombosis due to cryptogenic organising pneumopathy with antiphospholipid syndrome worsened by heparin-induced thrombocytopenia.
abstract: Cerebral venous thrombosis (CVT) has usually been ascribed to prothrombotic conditions, oral contraceptives, pregnancy, malignancy, infection, head injury or mechanical precipitants. The case reported here illustrates two rare causes of CVT observed in the same patient: the presence of antiphospholipid antibodies associated with an asymptomatic cryptogenic organising pneumopathy (COP) which were considered the origin of the venous cerebral thrombosis and heparin-induced thrombocytopenia (HIT) which was responsible for the worsening of the thrombosis observed a few days after the introduction of treatment. Moreover, we provide here additional positive experience in the treatment of both, CVT and HIT, by fondaparinux with bridging to warfarin given their successful evolution under this anticoagulant option.
authors.affiliation: Department of Neurology, Geneva University Hospital, Geneva, Switzerland. hsiehjulien@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Hsieh
authors.forename: I
authors.initials: I
authors.lastname: Kuzmanovic
authors.forename: M I
authors.initials: MI
authors.lastname: Vargas
authors.forename: I
authors.initials: I
authors.lastname: Momjian-Mayor
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects; D016736:Antiphospholipid Syndrome / Q000150:complications*; D018549:Cryptogenic Organizing Pneumonia / Q000150:complications*; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D020767:Intracranial Thrombosis / Q000209:etiology*; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications*; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D000925:Anticoagulants; D006493:Heparin