title: Biodegradable coumaric acid-based poly(anhydride-ester) synthesis and subsequent controlled release.
abstract: To overcome drug delivery issues associated with its short half-life in vivo, p-coumaric acid (pCA), a naturally occurring bioactive, has been chemically incorporated into a poly(anhydride-ester) backbone through solution polymerization. Nuclear magnetic resonance and Fourier transform infrared spectroscopies indicated that pCA was successfully incorporated without noticeable alterations in structural integrity. The polymer's weight-average molecular weight and thermal properties were determined, exhibiting a molecular weight of over 26 000 Da and a glass transition temperature of 57 °C. In addition, in vitro hydrolytic release studies demonstrated pCA release over 30 d with maintained antioxidant activity, demonstrating the polymer's potential as a controlled release system.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Rd., Piscataway, NJ, 08854, USA.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Ouimet
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Stebbins
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Uhrich
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D063566:Biodegradable Plastics / Q000138:chemical synthesis* / Q000737:chemistry; D003373:Coumaric Acids / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D005583:Fourier Analysis; D009682:Magnetic Resonance Spectroscopy; D011422:Propionates
chemical_list: D000975:Antioxidants; D063566:Biodegradable Plastics; D003373:Coumaric Acids; D003692:Delayed-Action Preparations; D011422:Propionates; C495469:p-coumaric acid
keywords: biodegradable; coumaric acid; drug delivery systems; poly(anhydride-ester); polymer