title: Preparation and properties of cyclic acetal based biodegradable gel by thiol-ene photopolymerization.
abstract: Synthetic, hydrolytically degradable biomaterials have been widely developed for biomedical use; however, most of them will form acidic products upon degradation of polymer backbone. In order to address this concern, we proposed to fabricate a biodegradable gel based on the crosslinking of a cyclic acetal monomer with reactable diallyl group and multifunctional thiols by thiol-ene photopolymerization. This gel produces diols and carbonyl end groups upon hydrolytic degradation and could be entirely devoid of acidic by-products. Real time infrared spectroscopy was employed to investigate the effect of different light intensities and concentrations of photoinitiator on the polymerization kinetics. With the increase of the concentration of photoinitiator and light intensity, both the rate of polymerization and final double bond conversion increased. Degradation of cyclic acetal based networks was investigated in PBS medium so as to simulate physiological conditions. The remaining mass of the materials after 25 days incubation was 84%. TGA analysis showed that the gels exhibited a typical weight loss (97.2%) at around 378 °C. In vitro cytotoxicity showed that the cyclic acetal based gels had non-toxicity to cell L-929 and had good biocompatibility.
authors.affiliation: School of Materials Science and Engineering, Changzhou University, Changzhou 213164, PR China. wangkm61@gmail.com
authors.forename: Kemin
authors.initials: K
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Lu
authors.forename: Ruixue
authors.initials: R
authors.lastname: Yin
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.forename: Shuang
authors.initials: S
authors.lastname: Du
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yu
mesh_terms: D015097:3-Mercaptopropionic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001673:Biodegradation, Environmental; D016923:Cell Death; D003432:Cross-Linking Reagents / Q000737:chemistry; D003500:Cyclization / Q000528:radiation effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005782:Gels / Q000138:chemical synthesis* / Q000737:chemistry; D006868:Hydrolysis / Q000187:drug effects; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008856:Microscopy, Fluorescence; D058105:Polymerization / Q000528:radiation effects*; D011409:Propylene Glycols / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D000080:Acetals; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D005782:Gels; D011409:Propylene Glycols; C501435:pentaerythritol tetra(3-mercaptopropionate); D015097:3-Mercaptopropionic Acid
keywords: Biodegradable; Cyclic acetal; Thiol-ene photopolymerization