title: Occurrence of disseminated intravascular coagulation in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced pneumonia in the rat.
abstract: Intensity of inflammatory reaction in tissue or organ structures depends on the efficiency of homeostatic mechanisms of the organism which limit the extent of this reaction. In studies on the dynamics of inflammatory reaction in induced pneumonia after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the occurrence of disseminated intravascular coagulation (DIC) has been observed. In this article we evaluated the DIC syndrome in regard to histopathological assessment and laboratory diagnostics of blood. The evaluation indicates that some hematologic indicators (RBC, HCT, and HGB) decreased in the experimental inflammatory reaction, which might be associated with erythrocyte hemolysis in the inflammatory focus and erythrocyte elimination from circulation as a result of DIC. There also were shifts in the number of various leukocyte forms due likely to the accumulation of particular cells in the inflammatory focus. Histopathological assessment of the inflammatory focus revealed the process of hepatization and the occurrence of DIC.
authors.affiliation: Department of Nervous System Diseases, Faculty of Health Science, Wroclaw Medical University, 5 Bartla St., 51-618, Wroclaw, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Calkosinski
authors.forename: J
authors.initials: J
authors.lastname: Rosinczuk-Tonderys
authors.forename: M
authors.initials: M
authors.lastname: Dobrzynski
authors.forename: L
authors.initials: L
authors.lastname: Palka
authors.forename: J
authors.initials: J
authors.lastname: Bazan
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D004147:Dioxins / Q000737:chemistry; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000150:complications*; D004912:Erythrocytes / Q000166:cytology; D005260:Female; D005340:Fibrinogen / Q000737:chemistry; D006461:Hemolysis; D006706:Homeostasis; D007249:Inflammation; D008168:Lung / Q000473:pathology; D010998:Pleurisy / Q000139:chemically induced / Q000378:metabolism; D011014:Pneumonia / Q000139:chemically induced*; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects*; D051381:Rats
chemical_list: D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D005340:Fibrinogen