title: Noninvasive Quality Control of Cryopreserved Samples.
abstract: We present a novel noninvasive technology for quality control in biobanking. We implemented a contactless optical in situ method with a remote detection unit. The method detects physical and chemical changes by emission spectroscopy. In the present study, ice formation in a vitrified sample is revealed by Raman scattering. The technology allows us to monitor sample quality during cold storage and to assess the sample state after preservation, storage, or transport without the need for thawing.
authors.forename: Daniel
authors.initials: D
authors.lastname: Dörr
authors.forename: Frank
authors.initials: F
authors.lastname: Stracke
authors.forename: Heiko
authors.initials: H
authors.lastname: Zimmermann
mesh_terms: D018070:Biological Specimen Banks / Q000592:standards*; D015925:Cryopreservation; D007053:Ice; D011786:Quality Control; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods*; D058989:Vitrification
chemical_list: D007053:Ice