title: Higher incidence of acute kidney injury with intravenous colistimethate sodium compared with polymyxin B in critically ill patients at a tertiary care medical center.
abstract: Nephrotoxicity was assessed in 173 critically ill patients receiving intravenous colistin or polymyxin B; it occurred in 60.4% and 41.8%, respectively. Further investigation is necessary to elucidate the reason for the difference in nephrotoxicity observed between the groups and to assess the impact of severity of illness and dosing/administration.
authors.affiliation: Department of Pharmacy Practice, D'Youville College School of Pharmacy, Buffalo.
authors.forename: Darowan S
authors.initials: DS
authors.lastname: Akajagbor
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Wilson
authors.forename: Kapana D
authors.initials: KD
authors.lastname: Shere-Wolfe
authors.forename: Paul
authors.initials: P
authors.lastname: Dakum
authors.forename: Manhattan E
authors.initials: ME
authors.lastname: Charurat
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Gilliam
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000453:epidemiology*; D061605:Administration, Intravenous; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015331:Cohort Studies; D003091:Colistin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D016638:Critical Illness; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011112:Polymyxin B / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D062606:Tertiary Care Centers
chemical_list: D000900:Anti-Bacterial Agents; C004691:colistinmethanesulfonic acid; D011112:Polymyxin B; D003091:Colistin
keywords: AKI; PB; colistimethate sodium; colistin; nephrotoxicity