title: Evidence for circulatory benefits of resveratrol in humans.
abstract: Impairments of endothelial function, which can be assessed noninvasively by flow-mediated dilation (FMD) of the brachial artery, contribute to the development of cardiovascular disease. Associations between FMD and cognition suggest a vascular component in the loss of cognitive function. Certain vasoactive nutrients that have been shown to improve FMD may also have the potential to enhance cerebral perfusion and cognition. Preclinical studies show that trans-resveratrol can enhance nitric oxide bioavailability, thereby increasing endothelium-dependent vasodilation. We have now shown that acute administration of resveratrol elicits dose-dependent increases of FMD with greater potency than other vasoactive nutrients and that this benefit is sustained following regular consumption. We describe the potential implications of this vasodilator benefit of resveratrol and its role in enhancing cerebrovascular and cognitive functions.
authors.affiliation: Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
authors.forename: Rachel H X
authors.initials: RH
authors.lastname: Wong
authors.forename: Alison M
authors.initials: AM
authors.lastname: Coates
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Buckley
authors.forename: Peter R C
authors.initials: PR
authors.lastname: Howe
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000378:metabolism / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D013267:Stilbenes; D014665:Vasodilator Agents; D000077185:Resveratrol
keywords: endothelial function; flow-mediated dilation; human; resveratrol; trans-resveratrol; vasodilator responsiveness