title: Association of CTSZ rs34069356 and MC3R rs6127698 gene polymorphisms with pulmonary tuberculosis.
abstract: OBJECTIVE
  To evaluate the possible association between cathepsin Z (CTSZ) rs34069356 C/T (Ala286Thr) and melanocortin-3 receptor (MC3R) rs6127698 G>T (-484 G/T) gene polymorphisms and pulmonary tuberculosis (PTB) in an Iranian sample population.
  
  
  METHODS
  This case-control study included 150 PTB patients and 177 healthy subjects. Tetra amplification refractory mutation system-polymerase chain reaction was used to detect polymorphisms.
  
  
  RESULTS
  Our findings revealed that the MC3R rs6127698 TT genotype increased the risk of PTB compared with GG (additive model: OR 2.24, 95%CI 1.13-4.64, P = 0.021) as well as GG+GT (recessive model: OR 1.89, 95%CI 1.13-3.18, P = 0.016). The rs6127698 T allele increased the risk of PTB (OR 1.56, 95%CI 1.14-2.13, P = 0.005) compared to the G allele. The CTSZ rs34069356 polymorphism was not associated with PTB in additive-, dominant- and recessive-tested inheritance models (P > 0.05).
  
  
  CONCLUSIONS
  Our data suggest that MC3R rs6127698, but not CTSZ rs34069356 polymorphism, is associated with PTB in a sample Iranian population.
authors.affiliation: Cellular and Molecular Research Centre, Zahedan University of Medical Sciences, Zahedan, Iran. hashemim@zaums.ac.ir
authors.forename: M
authors.initials: M
authors.lastname: Hashemi
authors.forename: E
authors.initials: E
authors.lastname: Eskandari-Nasab
authors.forename: A
authors.initials: A
authors.lastname: Moazeni-Roodi
authors.forename: M
authors.initials: M
authors.lastname: Naderi
authors.forename: B
authors.initials: B
authors.lastname: Sharifi-Mood
authors.forename: M
authors.initials: M
authors.lastname: Taheri
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D056663:Cathepsin Z / Q000235:genetics*; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D044104:Receptor, Melanocortin, Type 3 / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000235:genetics*
chemical_list: C505392:MC3R protein, human; D044104:Receptor, Melanocortin, Type 3; C534182:CTSZ protein, human; D056663:Cathepsin Z