title: Disparity between dorsal and ventral networks in patients with obsessive-compulsive disorder: evidence revealed by graph theoretical analysis based on cortical thickness from MRI.
abstract: As one of the most widely accepted neuroanatomical models on obsessive-compulsive disorder (OCD), it has been hypothesized that imbalance between an excitatory direct (ventral) pathway and an inhibitory indirect (dorsal) pathway in cortico-striato-thalamic circuit underlies the emergence of OCD. Here we examine the structural network in drug-free patients with OCD in terms of graph theoretical measures for the first time. We used a measure called efficiency which quantifies how a node transfers information efficiently. To construct brain networks, cortical thickness was automatically estimated using T1-weighted magnetic resonance imaging. We found that the network of the OCD patients was as efficient as that of healthy controls so that the both networks were in the small-world regime. More importantly, however, disparity between the dorsal and the ventral networks in the OCD patients was found in terms of graph theoretical measures, suggesting a positive evidence to the imbalance theory on the underlying pathophysiology of OCD.
authors.affiliation: Department of Brain and Cognitive Sciences, Seoul National University Seoul, South Korea ; Research Group for Cortical Networks and Cognitive Functions, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.
authors.forename: Seung-Goo
authors.initials: SG
authors.lastname: Kim
authors.forename: Wi Hoon
authors.initials: WH
authors.lastname: Jung
authors.forename: Sung Nyun
authors.initials: SN
authors.lastname: Kim
authors.forename: Joon Hwan
authors.initials: JH
authors.lastname: Jang
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
keywords: cortical thickness; dorsal-ventral imbalance; graph theoretical analysis; magnetic resonance imaging; network efficiency; obsessive-compulsive disorder; small-worldness; structural connectivity