title: Laparoscopic splenectomy for treatment of splenic marginal zone lymphoma.
abstract: OBJECTIVE
  To investigate the short-term and long-term efficacy and safety of laparoscopic splenectomy (LS) for treatment of splenic marginal zone lymphoma (SMZL).
  
  
  METHODS
  A total of 18 continuous patients who were diagnosed with SMZL and underwent LS in our department from 2008 to 2012 were reviewed. The perioperative variables and long-term follow-up were evaluated. To evaluate the efficacy and safety of this procedure better, we also included 34 patients with liver cirrhosis who underwent LS, 49 patients with immune thrombocytopenia (ITP) who underwent LS, and 20 patients with SMZL who underwent open splenectomy (OS). The results observed in the different groups were compared.
  
  
  RESULTS
  No differences were found in the sex and Child-Pugh class of the patients in SMZL-LS, SMZL-OS, ITP, and liver cirrhosis groups. The splenic length of the patients in the SMZL-LS group was similar to that in the SMZL-OS and liver cirrhosis groups but significantly longer than in the ITP group. The SMZL-LS group had a significantly longer operating time compared with the SMZL-OS, ITP, and liver cirrhosis groups, and the SMZL-LS group exhibited significantly less blood loss compared with the SMZL-OS group. No difference was found in the length of the postoperative hospital stay between the SMZL-LS, SMZL-OS, ITP, and liver cirrhosis-LS groups. After surgery, 6 (33.3%) SMZL-LS patients suffered slight complications. During mean follow-up periods of 13.6 and 12.8 mo, one patient from the SMZL-LS group and two from the SMZL-OS group died as a result of metastasis after surgery. None of the ITP and liver cirrhosis patients died.
  
  
  CONCLUSIONS
  LS should be considered a feasible and safe procedure for treatment of SMZL in an effort to improve the treatment options and survival of patients.
authors.affiliation: Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wu
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Yong-Bin
authors.initials: YB
authors.lastname: Li
authors.forename: Ting
authors.initials: T
authors.lastname: Niu
authors.forename: Bing
authors.initials: B
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods*; D008103:Liver Cirrhosis / Q000150:complications; D018442:Lymphoma, B-Cell, Marginal Zone / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000601:surgery; D012189:Retrospective Studies; D013156:Splenectomy / Q000009:adverse effects* / Q000379:methods*; D013160:Splenic Neoplasms / Q000401:mortality / Q000601:surgery*; D013163:Splenomegaly / Q000209:etiology / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Immune thrombocytopenia; Laparoscopic splenectomy; Liver cirrhosis; Open splenectomy; Splenic marginal zone lymphoma