title: Cytoglobin and neuroglobin in the human brainstem and carotid body.
abstract: The aim of the present study was to evaluate the presence of Neuroglobin (Ngb) and Cytoglobin (Cygb) in the solitary tract nucleus (STN) and in the carotid body of human subjects. Transverse serial sections of formalin-fixed, paraffin-embedded brainstems, taken from six subjects, were investigated. Ngb and Cygb are expressed in both the structures. Differences in expression of Ngb and Cygb among dorsal and ventral area of the STN may be related to their different functions and different metabolic demands. Because the STN plays an important role in the processing of cardiovascular and respiratory reflex inputs, Ngb and Cygb may play an integrative central modulatory action for the two systems.
authors.affiliation: Department of Neurosciences and Imaging, University of Chieti, 31 Via dei Vestini, 66100, Chieti, Italy, digiulio@unich.it.
authors.forename: C
authors.initials: C
authors.lastname: Di Giulio
authors.forename: S
authors.initials: S
authors.lastname: Zara
authors.forename: M
authors.initials: M
authors.lastname: De Colli
authors.forename: R
authors.initials: R
authors.lastname: Ruffini
authors.forename: A
authors.initials: A
authors.lastname: Porzionato
authors.forename: V
authors.initials: V
authors.lastname: Macchi
authors.forename: R
authors.initials: R
authors.lastname: De Caro
authors.forename: A
authors.initials: A
authors.lastname: Cataldi
mesh_terms: D001933:Brain Stem / Q000378:metabolism*; D002344:Carotid Body / Q000378:metabolism*; D000078842:Cytoglobin; D003720:Densitometry; D005786:Gene Expression Regulation; D005914:Globins / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000078787:Neuroglobin; D018377:Neurotransmitter Agents / Q000378:metabolism; D017552:Solitary Nucleus / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: C000627265:CYGB protein, human; D000078842:Cytoglobin; D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D018377:Neurotransmitter Agents; D005914:Globins