title: Cardiovascular Risk in Women With PCOS.
abstract: Polycystic ovary syndrome (PCOS), or Stein-Leventhal syndrome, is a common endocrine disorder defined by two of the three following features: i) oligoovulation or anovulation, ii) clinical and/or biochemical signs of hyperandrogenism, or iii) polycystic ovaries, once the related endocrinological and gynaecological disorders have been excluded. PCOS does not exclusively involve the reproductive apparatus , it has a complex number of systemic relevancy symptoms. It leads to Metabolic Syndrome, with severe consequences on the cardiovascular apparatus. Many clinical studies have underlined the connection between PCOS and the cardiovascular risk profile of such female patients, due to a lipid/glucose altered metabolism, hypertension, systemic inflammatory condition (assessable by markers such as VES, TNF-alfa, citokines and C-reactive protein (hsPCR) levels), and vascular injuries. Considering the early onset of the disease, PCOS could be considered as a real cardiovascular risk factor which affects the quality of life seriously. The current review aimed to point out the main connections between PCOS and cardiovascular risk factors according to the latest findings coming from literature data analysis, and try to depict the great influences that such a common disease can have on the patients' health integrity.
authors.affiliation: Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Scicchitano
authors.forename: Ilaria
authors.initials: I
authors.lastname: Dentamaro
authors.forename: Rosa
authors.initials: R
authors.lastname: Carbonara
authors.forename: Gabriella
authors.initials: G
authors.lastname: Bulzis
authors.forename: Annamaria
authors.initials: A
authors.lastname: Dachille
authors.forename: Paola
authors.initials: P
authors.lastname: Caputo
authors.forename: Roberta
authors.initials: R
authors.lastname: Riccardi
authors.forename: Manuela
authors.initials: M
authors.lastname: Locorotondo
authors.forename: Cosimo
authors.initials: C
authors.lastname: Mandurino
authors.forename: Marco
authors.initials: M
authors.lastname: Matteo Ciccone
keywords: Cardiovascular Risk; Diabetes; Hypertension; Metabolic Syndrome; PCOS