title: Novel method for early signs of clinical shock detection by monitoring blood capillary/vessel spatial pattern.
abstract: The ability to monitor capillary/vessel spatial patterns and local blood volume fractions is critical in clinical shock detection and its prevention in Intensive Care Units (ICU). Although the causes of shock might be different, the basic abnormalities in pathophysiological changes are the same. To detect these changes, we have developed a novel method based on both spectrally and spatially resolved diffuse reflectance spectra. The preliminary study has shown that this method can monitor the spatial distribution of capillary/vessel spatial patterns through local blood volume fractions of reduced hemoglobin and oxyhemoglobin. This method can be used as a real-time and non-invasive tool for the monitoring of shock development and feedback on the therapeutic intervention.
authors.affiliation: Clinical Photonics Lab., Erlangen Graduate School in Advanced Optical Technologies SAOT, Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 6, 91052 Erlangen, Germany; Institute of Photonic Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 3, 91052 Erlangen, Germany. Rajesh.Kanawade@aot.uni-erlangen.de.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kanawade
authors.forename: Florian
authors.initials: F
authors.lastname: Klämpfl
authors.forename: Max
authors.initials: M
authors.lastname: Riemann
authors.forename: Christian
authors.initials: C
authors.lastname: Knipfer
authors.forename: Katja
authors.initials: K
authors.lastname: Tangermann-Gerk
authors.forename: Michael
authors.initials: M
authors.lastname: Schmidt
authors.forename: Florian
authors.initials: F
authors.lastname: Stelzle
mesh_terms: D001810:Blood Volume / Q000502:physiology; D001811:Blood Volume Determination / Q000295:instrumentation / Q000379:methods; D002196:Capillaries / Q000473:pathology* / Q000503:physiopathology*; D006454:Hemoglobins / Q000378:metabolism; D008953:Models, Anatomic; D008954:Models, Biological; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D061848:Optical Imaging / Q000295:instrumentation / Q000379:methods*; D010108:Oxyhemoglobins / Q000378:metabolism; D012039:Regional Blood Flow / Q000502:physiology; D012769:Shock / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D012879:Skin Physiological Phenomena
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins
keywords: Clinical shock; epithelium capillary/vessel spatial pattern; oxygen saturation (SO2); oxyhemoglobin (HbO2); reduced hemoglobin (RHb); skin tissue phantom; spatially resolved diffuse reflectance