title: Hippolachnin A, a new antifungal polyketide from the South China Sea sponge Hippospongia lachne.
abstract: Hippolachnin A (1), a polyketide possessing an unprecedented carbon skeleton with a four-membered ring, was isolated from the South China Sea sponge Hippospongia lachne. The structure was elucidated using MS and NMR spectroscopic analyses, and the absolute configuration was determined using a calculated ECD method. Hippolachnin A demonstrated potent antifungal activity against three pathogenic fungi, Cryptococcus neoformans, Trichophyton rubrum, and Microsporum gypseum, with a MIC value of 0.41 μM for each fungus.
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China.
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Piao
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Song
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jiao
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Xiang-Fang
authors.initials: XF
authors.lastname: Liu
authors.forename: Wan-Sheng
authors.initials: WS
authors.lastname: Chen
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Han
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification; D002681:China; D003455:Cryptococcus neoformans / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry*; D009792:Oceans and Seas; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification; D011161:Porifera / Q000737:chemistry*; D014249:Trichophyton / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D061065:Polyketides; C585986:hippolachnin A