title: The impact of SLCO1B1 genetic polymorphisms on neonatal hyperbilirubinemia: a systematic review with meta-analysis.
abstract: OBJECTIVE
  To determine whether three variants (388 G>A, 521 T>C, and 463 C>A) of the solute carrier organic anion transporter family member 1B1 (SLCO1B1) are associated with neonatal hyperbilirubinemia.
  
  
  METHODS
  The China National Knowledge Infrastructure and MEDLINE databases were searched. The systematic review with meta-analysis included genetic studies which assessed the association between neonatal hyperbilirubinemia and 388 G>A, 521 T>C, and 463 C>A variants of SLCO1B1 between January of 1980 and December of 2012. Data selection and extraction were performed independently by two reviewers.
  
  
  RESULTS
  Ten articles were included in the study. The results revealed that SLCO1B1 388 G>A is associated with an increased risk of neonatal hyperbilirubinemia (OR, 1.39; 95% CI, 1.07-1.82) in Chinese neonates, but not in white, Thai, Latin American, or Malaysian neonates. The SLCO1B1 521 T>C mutation showed a low risk of neonatal hyperbilirubinemia in Chinese neonates, while no significant associations were found in Brazilian, white, Asian, Thai, and Malaysian neonates. There were no significant differences in SLCO1B1 463 C>A between the hyperbilirubinemia and the control group.
  
  
  CONCLUSIONS
  This study demonstrated that the 388 G>A mutation of the SLCO1B1 gene is a risk factor for developing neonatal hyperbilirubinemia in Chinese neonates, but not in white, Thai, Brazilian, or Malaysian populations; the SLCO1B1 521 T>C mutation provides protection for neonatal hyperbilirubinemia in Chinese neonates, but not in white, Thai, Brazilian, or Malaysian populations.
authors.affiliation: PhD. Department of Pediatrics, The Fifth People's Hospital of Shenzhen, Shenzhen, China. Electronic address: jiebol@126.com.
authors.forename: Jiebo
authors.initials: J
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Long
authors.forename: Shaofang
authors.initials: S
authors.lastname: Zhang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Fang
authors.forename: Yuyuan
authors.initials: Y
authors.lastname: Luo
mesh_terms: D044466:Asian People / Q000235:genetics; D001938:Brazil; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D015331:Cohort Studies; D005838:Genotype; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000235:genetics*; D007231:Infant, Newborn; D027381:Liver-Specific Organic Anion Transporter 1; D008296:Malaysia; D009154:Mutation / Q000235:genetics; D027361:Organic Anion Transporters / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013785:Thailand; D014421:Turkey; D014481:United States; D044465:White People / Q000235:genetics
chemical_list: D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; C503999:SLCO1B1 protein, human
keywords: Genetic polymorphisms; Hiperbilirrubinemia neonatal; Meta-analysis; Metanálise; Neonatal hyperbilirubinemia; Organic anion transport polypeptide C; Polimorfismos genéticos; Polipeptídeo C de transporte de ânions orgânicos