title: [The pathophysiological roles and regulatory mechanism of retinoic acid receptor-related orphan receptors].
abstract: Nuclear receptors are a large superfamily of transcription factors that regulate genes important to physiological functions. Retinoid-related orphan receptors (RORs), also known as NF1R, are so named because its gene sequence is similar to retinoid acid receptor and retinoid X receptor. RORs subfamily consists of three members: RORalpha, RORbeta, and RORgamma. Previous studies have established key roles for the RORs in physiological development, cytogenesis and differentiation of immune cells, circadian rhythm, and metabolism, through the regulation of gene expression. Besides, RORs also involve in many pathological process. Recent studies indicated that the abnormal expression of RORs is related to the development of tumor, immune inflammatory diseases, and cardiovascular diseases. thought to be the one of the key transcription factors which regulate the gene expression of these diseases. This review discusses the biological characteristics and pathophysiological roles of RORs subfamily.
authors.affiliation: Department of Cardiology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Chai
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Pu
authors.forename: Ben
authors.initials: B
authors.lastname: He
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000502:physiology*
chemical_list: D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; C539738:RORA protein, human; C539739:Rora protein, mouse