title: Enantioselective conjugate addition of 3-fluoro-oxindoles to vinyl sulfone: an organocatalytic access to chiral 3-fluoro-3-substituted oxindoles.
abstract: An organocatalytic conjugate addition of prochiral 3-fluorinated oxindoles to vinyl sulfones was described for the first time. In the presence of bifunctional tertiary amine-thiourea catalysts, 3-fluoro-3-substituted oxindole adducts were obtained in excellent yields and with high enantiomeric excesses.
authors.affiliation: Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Dou
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D002384:Catalysis; D054879:Halogenation; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D000078183:Oxindoles; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
chemical_list: D007211:Indoles; D000078183:Oxindoles; D013450:Sulfones; C022960:2-oxindole; C009873:divinyl sulfone