title: Serum and CSF biomarkers in acute pediatric neurological disorders.
abstract: BACKGROUND
  There have been numerous reports regarding serum or cerebrospinal fluid (CSF) biomarkers in various disorders; however, the validities of such biomarkers for more precise diagnoses and prognosis estimates remain to be determined, especially in pediatric patients with neurological disorders.
  
  
  METHODS
  Serum/CSF S100B, neuron-specific enolase, and total tau (tTau) were measured in various acute pediatric neurological disorders, and their usefulness for diagnostic and prognostic predictions was validated using receiver operating characteristic curves and area under the curve (AUC) analysis.
  
  
  RESULTS
  A total of 336 serum and 200 CSF specimens from 313 patients were examined, and we identified statistically significant differences that were relevant from diagnostic and prognostic viewpoints. CSF and serum tTau levels could be good predictors for diagnosis (CSF tTau; AUC=0.76) and prognosis (serum tTau; AUC=0.78).
  
  
  CONCLUSIONS
  Both CSF and serum tTau levels could be useful for precise diagnostic and prognostic estimations in acute pediatric neurological disorders. Further studies are needed to clarify the clinical significance of such biomarkers.
authors.affiliation: Department of Neurology, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa, Gunma 377-8577, Japan. Electronic address: shiihara-ind@umin.net.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shiihara
authors.affiliation: Department of Laboratory Medicine, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa, Gunma 377-8577, Japan.
authors.forename: Taeko
authors.initials: T
authors.lastname: Miyake
authors.affiliation: Department of Laboratory Medicine, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa, Gunma 377-8577, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Izumi
authors.affiliation: Department of Neurology, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa, Gunma 377-8577, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Sugihara
authors.affiliation: Department of Neurology, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa, Gunma 377-8577, Japan.
authors.forename: Mio
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Department of Pediatrics, Kameda Medical Center, 929 Higashi-cho, Kamogawa-shi, Chiba 296-8602, Japan.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Takanashi
authors.affiliation: Division of Neurology, National Center for Child Health and Development, 2-10-1 Ohkura, Setagaya-Ku, Tokyo 157-8535, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Kubota
authors.affiliation: Department of Pediatrics, Yamagata University Faculty of Medicine, 2-2-2 Iida-Nishi, Yamagata-shi, Yamagata 990-9585, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kato
mesh_terms: D000208:Acute Disease; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D010751:Phosphopyruvate Hydratase / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D011379:Prognosis; D012372:ROC Curve; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D012680:Sensitivity and Specificity; D016875:tau Proteins / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C054369:MAPT protein, human; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D016875:tau Proteins; D010751:Phosphopyruvate Hydratase
keywords: Area under the curve; Neuron-specific enolase; Receiver operating characteristic curves; S100B; Total tau