title: Hepatocellular carcinoma and food contamination: aflatoxins and ochratoxin A as a great prompter.
abstract: Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular carcinoma (HCC) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. Secondary metabolites, like aflatoxins and ochratoxin A (OTA), produced by some fungi species stocked in an inappropriate manner are considered an important way to increase HCC incidence. Future epidemiologic studies of HCC should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods.
authors.affiliation: Division of Nephrology, Department of Medicine, Federal University of Sao Paulo, Sao Paulo CEP 05508-900, Brazil.
authors.forename: Raphael J F
authors.initials: RJ
authors.lastname: Felizardo
authors.forename: Niels O S
authors.initials: NO
authors.lastname: Câmara
mesh_terms: D000348:Aflatoxins / Q000009:adverse effects*; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology*; D005506:Food Contamination; D014943:Global Health; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology*; D009793:Ochratoxins / Q000009:adverse effects*; D012307:Risk Factors; D014944:World Health Organization
chemical_list: D000348:Aflatoxins; D002273:Carcinogens; D009793:Ochratoxins; C025589:ochratoxin A
keywords: Egypt; Food contamination; Hepatocellular carcinoma; Liver cancer; Mycotoxin; Ochratoxin A