title: Biodegradable biliary stent implantation in the treatment of benign bilioplastic-refractory biliary strictures: preliminary experience.
abstract: OBJECTIVE
  To evaluate feasibility, safety, and outcome of patients treated with biodegradable biliary stents for benign biliary stenosis refractory to other treatments.
  
  
  METHODS
  Between March 2011 and September 2012, ten patients (seven men, three women; age 59 ± 7 years) with recurrent cholangitis due to postsurgical biliary stricture, previous multiple unsuccessful (two to five) bilioplasties, and unsuitability for surgical/endoscopic repair underwent percutaneous implantation of a biodegradable biliary stent. Patients were followed-up clinically and with ultrasound at 1, 3 and 6 months, and then at 6-month intervals.
  
  
  RESULTS
  Stent implantation was always feasible. No immediate major or minor complications occurred. In all patients, 48-h cholangiographic control demonstrated optimal stent positioning and stenosis resolution. In a median follow-up time of 16.5 months (25th-75th percentiles = 11-20.25 months) no further invasive treatment was needed. Three patients experienced transient episodes of cholangitis. Neither re-stenosis nor dilatation of the biliary tree was documented during follow-up. No stent was visible at the 6-month follow-up.
  
  
  CONCLUSIONS
  Percutaneous placement of biodegradable biliary stents represents a new option in treating benign biliary stenoses refractory to treatment with bilioplasty. This technique seems to be feasible, effective and free from major complications. Further investigations are warranted to confirm our preliminary results.
authors.affiliation: Servizio di Radiologia, IRCCS Policlinico San Donato, San Donato Milanese, Milano, Italy, vanni.mauri@gmail.com.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Mauri
authors.forename: Caterina
authors.initials: C
authors.lastname: Michelozzi
authors.forename: Fabio
authors.initials: F
authors.lastname: Melchiorre
authors.forename: Dario
authors.initials: D
authors.lastname: Poretti
authors.forename: Marco
authors.initials: M
authors.lastname: Tramarin
authors.forename: Vittorio
authors.initials: V
authors.lastname: Pedicini
authors.forename: Luigi
authors.initials: L
authors.lastname: Solbiati
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Cornalba
authors.forename: Luca Maria
authors.initials: LM
authors.lastname: Sconfienza
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects; D001659:Biliary Tract; D002761:Cholangitis / Q000209:etiology; D002779:Cholestasis / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000628:therapy; D004724:Endoscopy; D005240:Feasibility Studies; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019512:Pancreatitis, Alcoholic / Q000150:complications; D019919:Prosthesis Implantation / Q000379:methods*; D012008:Recurrence; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects; D014463:Ultrasonography