title: Addition of prednisolone and heparin in patients with failed IVF/ICSI cycles: a preliminary report of a clinical trial.
abstract: Through a non-randomized clinical trial, we examined the theoretical benefit of the coadministration of low molecular weight heparin (LMWH) and prednisolone on pregnancy outcomes in women with previously failed IVF/ICSI cycles. Fifteen women constituted the study group, and were compared with 19 women receiving LMWH alone and another 18 women with no drugs. Our finding that the combination of the two drugs produced positive differences in terms of embryo quality, pregnancy and live birth rates points to the necessity for adequately powered randomized trials.
authors.affiliation: Assisted Reproduction Unit, 3rd Department of Obstetrics and Gynecology, University of Athens , Athens , Greece.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Siristatidis
authors.forename: Charalampos
authors.initials: C
authors.lastname: Chrelias
authors.forename: Maria
authors.initials: M
authors.lastname: Creatsa
authors.forename: Christos
authors.initials: C
authors.lastname: Varounis
authors.forename: Nikos
authors.initials: N
authors.lastname: Vrachnis
authors.forename: Zoe
authors.initials: Z
authors.lastname: Iliodromiti
authors.forename: Demetrios
authors.initials: D
authors.lastname: Kassanos
mesh_terms: D000022:Abortion, Spontaneous / Q000517:prevention & control; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D057239:Early Termination of Clinical Trials; D004477:Ectogenesis; D017984:Enoxaparin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D005307:Fertilization in Vitro; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D050498:Live Birth; D010865:Pilot Projects; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000187:drug effects; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D005300:Fertility Agents, Female; D005938:Glucocorticoids; D011239:Prednisolone