title: BioMEMS in drug delivery.
abstract: The drive to design micro-scale medical devices which can be reliably and uniformly mass produced has prompted many researchers to adapt processing technologies from the semiconductor industry. By operating at a much smaller length scale, the resulting biologically-oriented microelectromechanical systems (BioMEMS) provide many opportunities for improved drug delivery: Low-dose vaccinations and painless transdermal drug delivery are possible through precisely engineered microneedles which pierce the skin's barrier layer without reaching the nerves. Low-power, low-volume BioMEMS pumps and reservoirs can be implanted where conventional pumping systems cannot. Drug formulations with geometrically complex, extremely uniform micro- and nano-particles are formed through micromolding or with microfluidic devices. This review describes these BioMEMS technologies and discusses their current state of implementation. As these technologies continue to develop and capitalize on their simpler integration with other MEMS-based systems such as computer controls and telemetry, BioMEMS' impact on the field of drug delivery will continue to increase.
authors.affiliation: Department of Chemical and Biochemical Engineering, Seamans Center for the Engineering Arts & Sciences, University of Iowa, Iowa City, IA 52245, USA. Electronic address: eric-nuxoll@uiowa.edu.
authors.forename: Eric
authors.initials: E
authors.lastname: Nuxoll
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D015195:Drug Design; D004867:Equipment Design; D006801:Humans; D055617:Micro-Electrical-Mechanical Systems; D046210:Microfluidic Analytical Techniques; D009339:Needles; D013686:Telemetry
chemical_list: D003692:Delayed-Action Preparations
keywords: BioMEMS; Controlled release; Drug delivery; Microfabrication; Microneedle; Microparticles; Micropumps; Microvalves; Nanoparticles; Photolithography