title: Characterisation of one H6N6 influenza virus isolated from swine in China.
abstract: There is multiple evidence that swine may act as a vessel for the generation of novel influenza A viruses. In this study, we have analyzed the evolution and pathogenicity of one strain of H6N6 influenza virus isolated from swine with clinical signs of infection in China. Although phylogenetic analysis revealed that this virus might originate from domestic ducks, pathogenicity experiments indicated that the virus replicated in mice without prior adaptation. These findings suggest that the virus has transmitted from ducks to swine in China, and replicated in mammalian hosts without prior adaptation, which may pose a threat to both veterinary and public health.
authors.affiliation: College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Zhao
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Chen
authors.forename: Junqing
authors.initials: J
authors.lastname: Huang
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Wang
authors.forename: Daxin
authors.initials: D
authors.lastname: Peng
authors.forename: Xiufan
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D002681:China / Q000453:epidemiology; D005260:Female; D009980:Influenza A virus / Q000145:classification* / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology*
keywords: Evolution; H6N6; Influenza viruses; Phylogenetic analysis; Swine