title: A new cytotoxic cembrane diterpene from the roots of Euphorbia pekinensis Rupr.
abstract: A new cembrane diterpene, named (-)-(1S)-15-hydroxy-18-carboxycembrene, was isolated from petroleum ether extract of the roots of the Euphorbia pekinensis Rupr. To our knowledge, this compound is the first cembrane-type diterpenoid to be found in the family Euphorbiaceae. The structure was elucidated as (-)-(1S)-15-hydroxy-cembra -2E, 4Z, 7E, 11E-tetraen-18-oic acid by a combination of IR, HR-ESIMS, 1D- and 2D-NMR techniques. (-)-(1S)-15-hydroxy-18-carboxycembrene showed cytotoxic activity against all five human cancer cell lines tested.
authors.affiliation: The Engineering Laboratory of National and Local Union of Quality Control for Traditional Chinese Medicine, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Pengyi
authors.initials: P
authors.lastname: Hou
authors.forename: Yan
authors.initials: Y
authors.lastname: Zeng
authors.forename: Bingjie
authors.initials: B
authors.lastname: Ma
authors.forename: Kaishun
authors.initials: K
authors.lastname: Bi
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots
chemical_list: C588371:(-)-(1S)-15-hydroxy-18-carboxycembrene; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts
keywords: (−)-(1S)-15-hydroxy-18-carboxycembrene; Cembrane-type diterpene; Cytotoxic activity; Euphorbia pekinensis Rupr.