title: Impact of stress hyperglycemia on in-hospital stent thrombosis and prognosis in nondiabetic patients with ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention.
abstract: OBJECTIVE
  Stress hyperglycemia (SH) in a setting of acute myocardial infarction increases the risk of in-hospital mortality. The relationship between SH and in-hospital stent thrombosis (ST) is rare. The aim of our study was to assess the impact of SH on in-hospital ST and prognosis in nondiabetic patients with ST-segment elevation myocardial infarction (STEMI) undergoing a primary percutaneous coronary intervention (p-PCI).
  
  
  METHODS
  This study included 853 patients without diabetes mellitus with STEMI. All patients were treated with p-PCI. Blood glucose (BG) was measured on admission. The patients were divided into two groups on the basis of admission BG (SH, BG≥180 mg/dl; non-SH, BG<180 mg/dl). The two groups were compared with respect to baseline characteristics and primary endpoints.
  
  
  RESULTS
  During hospitalization, all-cause mortality was 2.9%. The total incidence of ST was 1.9%. Patients with SH experienced a significantly higher incidence of mortality (P=0.045), ST (P=0.038), and composite major adverse cardiac events (MACE) (P=0.008) than patients without SH. Patients with SH extended hospital days (P<0.001). After multivariate analysis, SH was associated independently with in-hospital mortality, incidence of ST, and composite MACE.
  
  
  CONCLUSIONS
  In nondiabetic patients with STEMI undergoing p-PCI, the patients with SH experienced a significantly higher incidence of mortality, ST, and composite MACE.
authors.affiliation: Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing, China.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Zhang
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhou
authors.forename: Shu-Jun
authors.initials: SJ
authors.lastname: Cao
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Shi-Wei
authors.initials: SW
authors.lastname: Yang
authors.forename: Bin
authors.initials: B
authors.lastname: Nie
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003328:Coronary Thrombosis / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000453:epidemiology* / Q000401:mortality; D015994:Incidence; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology / Q000401:mortality / Q000628:therapy*; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000295:instrumentation* / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents; D013312:Stress, Physiological; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose