title: Association of metabolic syndrome and inflammation with neurocognition in patients with schizophrenia.
abstract: The aim of this study is to assess the relationships of metabolic syndrome (MetS) and inflammation with neurocognition in schizophrenia. In this cross-sectional study, we included patients with diagnosis of schizophrenia according to the DSM-IV-TR criteria. We collected socio-demographic information, clinical characteristics, anthropometric measurements, blood tests, and neurocognition measures. A multivariate analysis using multiple linear regressions was performed to determine variables that are potentially associated with neurocognition. The analyses were repeated using MetS as a dichotomised variable (< and ≥ 3 MetS criteria), a continuous variable (number of MetS criteria present), and for each component of MetS. One hundred and sixty-eight outpatients participated in our study. The prevalence of MetS was 27.4%. An association was found between the number of MetS criteria present and cognitive impairment. Among the different components of MetS, hypertriglycerides and abdominal obesity were the only factors associated with cognitive impairment. Other factors, such as smoking and alcohol dependence or abuse, also revealed a significant relationship, whereas inflammation was not associated with cognitive impairment. In conclusion, our findings suggest that MetS, alcohol use and non-smoking status are associated with cognitive impairment. These findings may support complementary therapeutic approaches in cognitive remediation that lessen the severity of cognitive impairment in schizophrenia.
authors.affiliation: Aix-Marseille University, EA 3279 - Public Health, Chronic Diseases and Quality of Life - Research Unit, 13005 Marseille, France. Electronic address: laurent.boyer@ap-hm.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Richieri
authors.forename: Daniel
authors.initials: D
authors.lastname: Dassa
authors.forename: Mohamed
authors.initials: M
authors.lastname: Boucekine
authors.forename: Jessica
authors.initials: J
authors.lastname: Fernandez
authors.forename: Florence
authors.initials: F
authors.lastname: Vaillant
authors.forename: Romain
authors.initials: R
authors.lastname: Padovani
authors.forename: Pascal
authors.initials: P
authors.lastname: Auquier
authors.forename: Christophe
authors.initials: C
authors.lastname: Lancon
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D003072:Cognition Disorders / Q000150:complications / Q000453:epidemiology / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010045:Outpatients; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D012565:Schizophrenic Psychology; D012907:Smoking; D012959:Socioeconomic Factors
keywords: Inflammation; Metabolic Syndrome; Neurocognition; Schizophrenia