title: Fatal diarrheal disease caused by Vibrio cholerae O67 in a patient with myelodysplastic syndrome.
abstract: A 71-year-old man with myelodysplastic syndrome (MDS) receiving treatment with azacitidine developed extensive watery diarrhea for three consecutive days. As a result of high-grade dehydration, the patient was urgently admitted to the hospital and fluid replacement therapy was initiated. However, the patient's diarrhea did not improve. Vibrio cholerae non-O1/non-O139 was detected in a fecal culture. On the fourth day, the patient died due to circulatory collapse. An autopsy revealed extensive necrosis of the intestinal mucosa. Vibrio cholerae non-O1/non-O139-induced diarrheal disease often develops in patients with hepatic cirrhosis and has a serious clinical course. We herein report a fatal outcome of Vibrio cholerae O67 infection in an immunocompromised MDS patient.
authors.affiliation: Department of Internal Medicine, Social Insurance Kinan Hospital, Japan. stamura@kinan-hp.tanabe.wakayama.jp
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tamura
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Taniguchi
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakamoto
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Nakamoto
authors.forename: Eiji
authors.initials: E
authors.lastname: Arakawa
authors.forename: Takahiko
authors.initials: T
authors.lastname: Fukuchi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nakano
authors.forename: Tokuzo
authors.initials: T
authors.lastname: Fujimoto
mesh_terms: D000368:Aged; D002771:Cholera / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D003967:Diarrhea / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D014734:Vibrio cholerae / Q000302:isolation & purification