title: Antimicrobial Brazilian Propolis (EPP-AF) Containing Biocellulose Membranes as Promising Biomaterial for Skin Wound Healing.
abstract: Among remarkable discoveries concerning propolis, such as antifungal, antiviral, and antioxidant activities, its anti-inflammatory, and mainly its antibacterial, properties deserve special attention when skin wound healing is concerned. Based on this and knowing the distinctive performance of bacterial (BC) membranes on wound healing, in this work it is proposed to demonstrate the potent antimicrobial activity and wound healing properties of a novel propolis containing biocellulose membrane. The obtained propolis/BC membrane was able to adsorb propolis not only on the surface, but also in its interstices demonstrated by scanning electron microscopy, X-ray diffraction, Fourier transform infrared (FT-IR) spectroscopy, and thermogravidimetric assays. Additionally, the polyphenolic compounds determination and the prominent antibacterial activity in the membrane are demonstrated to be dose dependent, supporting the possibility of obtaining propolis/BC membranes at the desired concentrations, taking into consideration its application and its skin residence time. Finally, it could be suggested that propolis/BC membrane may favor tissue repair in less time and more effectively in contaminated wounds.
authors.affiliation: Instituto de Química, Universidade Estadual Paulista (UNESP) CP 355, 14800-900 Araraquara, SP, Brazil.
authors.forename: Hernane da Silva
authors.initials: Hda S
authors.lastname: Barud
authors.forename: Adalberto Miguel
authors.initials: AM
authors.lastname: de Araújo Júnior
authors.forename: Sybele
authors.initials: S
authors.lastname: Saska
authors.forename: Letícia Boldrin
authors.initials: LB
authors.lastname: Mestieri
authors.forename: Juliana Alvares Duarte Bonini
authors.initials: JA
authors.lastname: Campos
authors.forename: Rubens Moreno
authors.initials: RM
authors.lastname: de Freitas
authors.forename: Nathália Ursoli
authors.initials: NU
authors.lastname: Ferreira
authors.forename: Andresa Piacezzi
authors.initials: AP
authors.lastname: Nascimento
authors.forename: Felipe Galeti
authors.initials: FG
authors.lastname: Miguel
authors.forename: Mirela Mara de Oliveira Lima Leite
authors.initials: MM
authors.lastname: Vaz
authors.forename: Edna Aparecida
authors.initials: EA
authors.lastname: Barizon
authors.forename: Franciane
authors.initials: F
authors.lastname: Marquele-Oliveira
authors.forename: Ana Maria Minarelli
authors.initials: AM
authors.lastname: Gaspar
authors.forename: Sidney José Lima
authors.initials: SJ
authors.lastname: Ribeiro
authors.forename: Andresa Aparecida
authors.initials: AA
authors.lastname: Berretta