title: Biomarkers of Helicobacter pylori-associated gastric cancer.
abstract: Helicobacter pylori-associated gastric cancer is a major cause of morbidity and mortality worldwide, and is predicted to become even more common in developing countries as the population ages. Since gastric cancer develops slowly over years to decades, and typically progresses though a series of well-defined histologic stages, cancer biomarkers have potential to identify asymptomatic individuals in whom surgery might be curative, or even those for whom antibiotics to eradicate H. pylori could prevent neoplastic transformation. Here we describe some of the challenges of biomarker discovery, summarize current approaches to biomarkers of gastric cancer, and explore some recent novel strategies.
authors.affiliation: Departments of Medicine and Microbiology & Immunology; University of California; Davis School of Medicine; Davis, CA USA; Center for Comparative Medicine; University of California; Davis School of Medicine; Davis, CA USA.
authors.forename: Cara L
authors.initials: CL
authors.lastname: Cooke
authors.affiliation: Infectious Diseases Research Unit; Instituto Mexicano del Seguro Social; Mexico City, Mexico.
authors.forename: Javier
authors.initials: J
authors.lastname: Torres
authors.affiliation: Departments of Medicine and Microbiology & Immunology; University of California; Davis School of Medicine; Davis, CA USA; Center for Comparative Medicine; University of California; Davis School of Medicine; Davis, CA USA; California National Primate Research Center; University of California; Davis School of Medicine; Davis, CA USA.
authors.forename: Jay V
authors.initials: JV
authors.lastname: Solnick
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D016481:Helicobacter Infections / Q000150:complications / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000382:microbiology*
chemical_list: D015415:Biomarkers
keywords: biomarkers; gastric cancer; helicobacter pylori