title: Purpurides B and C, two new sesquiterpene esters from the aciduric fungus Penicillium purpurogenum JS03-21.
abstract: Purpurides B and C (1 and 2, resp.), two new sesquiterpene alcohol esters generated from a drimane-type sesquiterpenoid lactone and an amino acid, together with two known analogs, berkedrimane B (3) and purpuride (4), were isolated from the aciduric fungus Penicillium purpurogenum JS03-21. Their structures were elucidated by spectroscopic analysis, X-ray single-crystal diffraction, and application of Marfey's method. Compounds 1-4 showed modest antifungal activities against Candida albicans with MIC values in the range of 1.2-3.3 μM. Compounds 1 and 2 showed moderate antimicrobial activities against Enterobacter aerogenes and Pseudomonas aeruginosa with MIC values in the range of 1.2-2.6 μM.
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Peipei
authors.initials: P
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Fan
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D021902:Enterobacter aerogenes / Q000187:drug effects; D004952:Esters; D018922:HL-60 Cells; D006801:Humans; D008968:Molecular Conformation; D010407:Penicillium / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: C586258:7-demethoxy-7,11-didehydropurpuride B; C586257:7-methoxypurpuride; D000890:Anti-Infective Agents; D004952:Esters; D012717:Sesquiterpenes
keywords: Antimicrobial activity; Fungi; Penicillium purpurogenum; Purpurides B and C; Sesquiterpenes