title: Chemopreventive potential of flavonoids in oral squamous cell carcinoma in human studies.
abstract: Evidence available from nutritional epidemiology has indicated an inverse association between regular consumption of fruits and vegetables and the risk of developing certain types of cancer. In turn, preclinical studies have attributed the health-promoting effects of plant foods to some groups of phytochemicals, by virtue of their many biological activities. In this survey, we briefly examine the chemopreventive potential of flavonoids and flavonoid-rich foods in human oral carcinogenesis. Despite the paucity of data from clinical trials and epidemiological studies, in comparison to in vitro/in vivo investigations, a high level of evidence has been reported for epigallocatechin gallate (EGCG) and anthocyanins. These flavonoids, abundant in green tea and black raspberries, respectively, represent promising chemopreventive agents in human oral cancer.
authors.affiliation: Department of Agricultural and Environmental Sciences, Milan State University, via G Celoria 2, Milan 20133, Italy. marcello.iriti@unimi.it
authors.forename: Marcello
authors.initials: M
authors.lastname: Iriti
authors.forename: Elena Maria
authors.initials: EM
authors.lastname: Varoni
mesh_terms: D058956:Administration, Mucosal; D016588:Anticarcinogenic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002392:Catechin / Q000031:analogs & derivatives / Q000627:therapeutic use; D018890:Chemoprevention; D016503:Drug Delivery Systems; D005419:Flavonoids / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000517:prevention & control*; D053758:Nanoparticles / Q000737:chemistry; D059808:Polyphenols / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D013662:Tea / Q000737:chemistry
chemical_list: D016588:Anticarcinogenic Agents; D005419:Flavonoids; D059808:Polyphenols; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate