title: The changing face of oral anticoagulants.
abstract: Warfarin has been the established oral anticoagulant for the last 50 years, being effective in the prevention and treatment of venous and arterial thromboembolic disorders. However, the frequent requirement for INR monitoring, multiple drug and food interactions have fuelled the need for development of new oral anticoagulants. Dabigatran is the first of a series of new oral anticoagulants that are emerging as the successors to warfarin. This new group of anticoagulants is rapidly gaining FDA and NICE approval and has proven non-inferiority to warfarin and viable alternatives to warfarin in the coming years. Given the obvious impact of this on dental treatment in the primary care and hospital setting this article aims to increase familiarisation with this new medicine group.
authors.affiliation: Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, UK. oliver.rider@gmail.com
authors.forename: O J
authors.initials: OJ
authors.lastname: Rider
authors.forename: E B
authors.initials: EB
authors.lastname: Rider
mesh_terms: D000925:Anticoagulants / Q000145:classification* / Q000627:therapeutic use; D058833:Antithrombin Proteins / Q000145:classification / Q000627:therapeutic use; D001562:Benzimidazoles / Q000145:classification / Q000627:therapeutic use; D000069604:Dabigatran; D065427:Factor Xa Inhibitors; D006801:Humans; D009025:Morpholines / Q000145:classification / Q000627:therapeutic use; D011355:Prodrugs / Q000145:classification / Q000627:therapeutic use; D011720:Pyrazoles / Q000145:classification / Q000627:therapeutic use; D011725:Pyridines / Q000145:classification / Q000627:therapeutic use; D011728:Pyridones / Q000145:classification / Q000627:therapeutic use; D000069552:Rivaroxaban; D013876:Thiophenes / Q000145:classification / Q000627:therapeutic use; D013923:Thromboembolism / Q000517:prevention & control; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D058833:Antithrombin Proteins; D001562:Benzimidazoles; D065427:Factor Xa Inhibitors; D009025:Morpholines; D011355:Prodrugs; D011720:Pyrazoles; D011725:Pyridines; D011728:Pyridones; D013876:Thiophenes; C522181:apixaban; D014859:Warfarin; D000069552:Rivaroxaban; D000069604:Dabigatran