title: Neurologic melioidosis.
abstract: Melioidosis is an important cause of morbidity and mortality in northern Australia and Southeast Asia. Diagnosis is best made by isolation of Burkholderia pseudomallei from clinical specimens. A variety of clinical presentations are described, including neurologic disease. The aim of this study was to review admissions with confirmed neurologic melioidosis to a regional hospital in a region to which melioidosis is endemic during 1995-2011. There were 12 culture-confirmed cases of neurologic melioidosis, of which two were detected by analysis of cerebrospinal fluid. Four of these cases were in children. Significant clinical features were fever, headache, and ataxia. Common changes on magnetic resonance imaging T2-weighted scans included ring-enhancing lesions and leptomeningeal enhancement. There were four deaths and an additional four patients had significant long-term neurologic sequelae. When considering the etiology of undifferentiated neurologic disease, an awareness of the possibility of neurologic melioidosis is important in disease-endemic regions.
authors.affiliation: Townsville Hospital, Townsville, Queensland, Australia. mjdeuble@gmail.com
authors.forename: Martin
authors.initials: M
authors.lastname: Deuble
authors.forename: Chloe
authors.initials: C
authors.lastname: Aquilina
authors.forename: Robert
authors.initials: R
authors.lastname: Norton
mesh_terms: D061605:Administration, Intravenous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001210:Asia, Southeastern; D001315:Australia; D016957:Burkholderia pseudomallei / Q000302:isolation & purification*; D002555:Cerebrospinal Fluid / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D019353:Endemic Diseases; D006760:Hospitalization; D006801:Humans; D008279:Magnetic Resonance Imaging; D008554:Melioidosis / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D009422:Nervous System Diseases / Q000382:microbiology*; D012307:Risk Factors; D013048:Specimen Handling; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents