title: Ovarian transposition before pelvic irradiation: indications and functional outcome.
abstract: OBJECTIVE
  To investigate the indications and effectiveness of ovarian transposition before pelvic irradiation.
  
  
  METHODS
  This was a retrospective analysis of patients with malignancies who underwent ovarian transposition before pelvic irradiation. The collected data included age of patient, type and stage of cancer, details of irradiation treatment, and clinical and biochemical parameters of ovarian function during the period of follow-up.
  
  
  RESULTS
  Fourteen adult and four pediatric patients with different types of cancers underwent ovarian transposition during the study period. The common tumor types for the adult patients were cervical cancer (n = 4), rectal cancer (n = 4) and medulloblastoma (n = 3), and for pediatric patients was medulloblastoma (n = 2). The mean age for adult patients was 31 years (range, 21-40) and for pediatric patients was 7 years (range, 4-10). Of the adult patients, 10 had adjuvant chemotherapy and four had neoadjuvant chemotherapy added to their radiotherapy program. All pediatric patients received adjuvant chemotherapy. Thirteen of 14 (92.85%) adult patients had normal serum level of follicle-stimulating hormone (FSH; ≤12 IU/L) and E2 (>50 pg/mL). Only one patient had premature menopause. All pediatric patients demonstrated a normal serum level of FSH (<12) and E2 for their age at 3 and 6 months after completion of their treatment. The mean follow-up was 42 months (range, 34-50).
  
  
  CONCLUSIONS
  Ovarian transposition is an effective procedure for the preservation of ovarian function. Young patients with non-hormone-dependent pelvic tumors should be offered a laparoscopic ovarian transposition before the start of pelvic radiotherapy.
authors.affiliation: Department of Surgery, King Hussein Cancer Center, Amman, Jordan.
authors.forename: Samer
authors.initials: S
authors.lastname: Barahmeh
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Al Masri
authors.forename: Osama
authors.initials: O
authors.lastname: Badran
authors.forename: Ma'in
authors.initials: M
authors.lastname: Masarweh
authors.forename: Mohammad
authors.initials: M
authors.lastname: El-Ghanem
authors.forename: Imad
authors.initials: I
authors.lastname: Jaradat
authors.forename: Isam
authors.initials: I
authors.lastname: Lataifeh
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D059247:Fertility Preservation; D013509:Gynecologic Surgical Procedures; D006801:Humans; D010053:Ovary / Q000601:surgery*; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D012189:Retrospective Studies; D055815:Young Adult
keywords: irradiation; malignancy; oophoropexy; ovarian transposition