title: Gender-based differences in oxidative stress parameters do not underlie the differences in mood disorders susceptibility between sexes.
abstract: The present study aimed to determine whether any gender-related difference exists concerning oxidative stress parameters in a population of 231 subjects, and if these changes might be related to gender-associated differences in major depressive disorder (MDD) or bipolar disorder (BD) vulnerability. This is a case-control nested in a population-based study. The initial psychopathology screen was performed with the Mini-International Neuropsychiatric Interview and the diagnostic was further confirmed with the Structured Clinical Interview for DSM-IV. Blood samples were obtained after the interview and the oxidative stress parameters such as uric acid, advanced oxidation protein product (PCC) and lipid hydroperoxides (TBARS) were determined. Our results indicated a higher prevalence of MDD and BD in women when compared to men. In addition, significant gender differences were found in the levels of PCC (0.27±0.27 vs. 0.40±0.31nmol CO/mg protein, men vs. women, respectively; P=0.02) and uric acid (4.88±1.39mg/dL vs. 3.53±1.02mg/dL, men vs. women, respectively; P=0.0001), but not in TBARS (0.013±0.01nmol/mg of protein vs. 0.017±0.02nmol/mg of protein, men vs. women respectively; P=0.243). After sample stratification by gender, no association was found between oxidative stress parameters and clinical diagnosis of MDD and BD for women (P=0.516 for PCC; P=0.620 for TBARS P=0.727 for uric acid) and men (P=0.367 for PCC; P=0.372 for TBARS P=0.664 for uric acid). In this study, women seem more susceptible to oxidative stress than male. However, these gender-based differences do not seem to provide a biochemical basis for the epidemiologic differences in mood disorders susceptibility between sexes.
authors.affiliation: Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Wiener
authors.affiliation: Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil.
authors.forename: G T
authors.initials: GT
authors.lastname: Rassier
authors.affiliation: Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil.
authors.forename: M P
authors.initials: MP
authors.lastname: Kaster
authors.affiliation: Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil.
authors.forename: K
authors.initials: K
authors.lastname: Jansen
authors.affiliation: Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil.
authors.forename: R T
authors.initials: RT
authors.lastname: Pinheiro
authors.affiliation: Universidade Federal do Rio Grande do Sul (UFRGS), Biochemistry Department, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Klamt
authors.affiliation: Universidade Federal do Rio Grande do Sul (UFRGS), National Institute for Translational Medicine, Hospital de Clínicas de Porto Alegre, Brazil.
authors.forename: P V
authors.initials: PV
authors.lastname: Magalhães
authors.affiliation: Universidade Federal do Rio Grande do Sul (UFRGS), National Institute for Translational Medicine, Hospital de Clínicas de Porto Alegre, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Kapczinski
authors.affiliation: Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil. Electronic address: ghisleni.g@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Ghisleni
authors.affiliation: Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil.
authors.forename: R A
authors.initials: RA
authors.lastname: da Silva
mesh_terms: D000293:Adolescent; D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D012737:Sex Factors; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D062107:Advanced Oxidation Protein Products; D017392:Thiobarbituric Acid Reactive Substances; D014527:Uric Acid
keywords: Bipolar disorder; Gender; Major depressive disorder; Oxidative stress