title: Prognostic significance of CD155 mRNA expression in soft tissue sarcomas.
abstract: CD155 was initially identified as a receptor for poliovirus. Several studies have demonstrated that CD155 overexpression in cancer cells is significant in their migration, invasion, proliferation and metastasis. The objective of the present study was to investigate the correlation betweenCD155expression and the clinical aggressiveness of soft tissue tumors. TheCD155expression levels in 43 surgically-resected soft tissue tumors were evaluated using the quantitative real-time polymerase chain reaction (PCR). The clinicopathogical factors affecting the expression levels ofCD155mRNA were investigated and the association between the expression levels ofCD155and patient prognosis was identified. TheCD155expression level was not correlated with the patient gender, site of the primary tumor, tumor depth, tumor size or presence of distant metastasis at presentation, but was correlated with patient age (Fisher's exact test). The local recurrence-free survival rate for patients with a highCD155expression level was observed to be significantly poorer compared with that of patients with lowCD155expression levels (P=0.0401). Moreover, a multivariate analysis indicated that a highCD155expression level was an independent adverse prognostic factor for local recurrence-free survival (hazard ratio, 6.369; P=0.0328). The present study therefore suggests that the expression level ofCD155is a useful marker for predicting the local recurrence of soft tissue tumors.
authors.affiliation: Departments of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Atsumi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Matsumine
authors.forename: Hidemi
authors.initials: H
authors.lastname: Toyoda
authors.forename: Rui
authors.initials: R
authors.lastname: Niimi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Iino
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sudo
keywords: CD155/PVR/Necl-5; biomarker; local recurrence; prognosis; soft tissue sarcoma