title: Highly sensitive and selective detection of dopamine based on hollow gold nanoparticles-graphene nanocomposite modified electrode.
abstract: Highly dispersed hollow gold-graphene (HAu-G) nanocomposites were synthesized by a two-step method. The immobilization of hollow gold nanoparticles (HAu NPs) onto the surface of graphene sheets was achieved by mixing an aqueous solution of HAu NPs with a poly(N-vinylpyrrolidone)-functionalized graphene dispersion at room temperature. A glassy carbon electrode (GCE) was modified with the nanocomposites, and the as-prepared modified electrode displayed high electrocatalytic activity and extraordinary electronic transport properties. Amperometric detection of dopamine (DA) performed with the HAu-G modified electrode exhibits a good linearity between 0.08 and 600 μM with a low detection limit of 0.05 μM (S/N=3) and also possesses good reproducibility and operational stability. The interference of ascorbic acid (AA) and uric acid (UA) can be excluded when using differential pulse voltammetric technique. In addition, this type of modified electrode can also be applied to the determination of DA content in dopamine hydrochloride injection. It is obvious that the HAu-G modified electrode provides a new way to detect dopamine sensitively and selectively.
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China; Department of Chemistry, Qilu Normal University, Jinan 250013, China.
authors.forename: Wencai
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Chen
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Ma
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. Electronic address: hyma@sdu.edu.cn.
authors.forename: Houyi
authors.initials: H
authors.lastname: Ma
authors.affiliation: State Key Laboratory for Corrosion and Protection, Shenyang 110016, China.
authors.forename: Shenhao
authors.initials: S
authors.lastname: Chen
mesh_terms: D002244:Carbon / Q000737:chemistry; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D015203:Reproducibility of Results
chemical_list: D002244:Carbon; D006046:Gold; D006108:Graphite; D004298:Dopamine
keywords: Amperometric detection; Dopamine; Electroanalysis; Graphene; Hollow gold nanoparticles; Modified electrode