title: Chemopreventive effect of montelukast in n-nitroso n-methyl urea induced mammary carcinogenesis in female Sprague-Dawley rats.
abstract: OBJECTIVE
  The objective of the study was to evaluate the chemopreventive effect of montelukast sodium; selective reversible cysteinyl leukotriene D4-receptor antagonist in N-nitroso N-methyl urea (NMU) induced mammary carcinogenesis in virgin female Sprague-Dawley rats.
  
  
  METHODS
  Thirty rats were divided into five groups (normal control, disease control, montelukast1 mg/kg, montelukast10 mg/kg, tamoxifen10 mg/kg) of six animals each. The drug was administered in two doses,1 mg/kg,and 10 mg/kg orally and compared with the standard drug tamoxifen (10 mg/kg)p.o.
  
  
  RESULTS
  Montelukast sodium 1 mg/kg,10 mg/kg, and tamoxifen10 mg/kg decreased the tumor incidences by 50%,66.67%, and 83.33% and the total number of tumors in group by 41.67%, 58.33% and 91.67% respectively, when compared to the disease control. Montelukast sodium 1 mg/kg,10 mg/kg,and tamoxifen10 mg/kg decreased the average tumor burden by 86.41%,94.8% and 95.97%and average tumor volume by 89.52%, 95.84%, and 95.4%respectively, when compared to disease control group.
  
  
  CONCLUSIONS
  The results revealed that montelukast sodium prevent the mammary carcinogenesis and confirms the role of cysteinyl leukotriene D4-receptor in mammary gland neoplasia.
authors.affiliation: Department of Pharmacology, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamil Nadu, India.
authors.forename: Manonmani Alvin
authors.initials: MA
authors.lastname: Jose
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Amathi
authors.forename: Duraiswami
authors.initials: D
authors.lastname: Sathyamurthy
authors.forename: Balasubramanian Nandha
authors.initials: BN
authors.lastname: Kumar
mesh_terms: D000085:Acetates / Q000627:therapeutic use*; D000477:Alkylating Agents; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D003521:Cyclopropanes; D005260:Female; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D015674:Mammary Neoplasms, Animal / Q000139:chemically induced / Q000188:drug therapy*; D008770:Methylnitrosourea; D011804:Quinolines / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018077:Receptors, Leukotriene; D013440:Sulfides
chemical_list: D000085:Acetates; D000477:Alkylating Agents; D016588:Anticarcinogenic Agents; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D018077:Receptors, Leukotriene; D013440:Sulfides; D008770:Methylnitrosourea; C083169:leukotriene D4 receptor; C093875:montelukast
keywords: Carcinogenesis; leukotrienes; tamoxifen