title: Development of (177)Lu-phytate Complex for Radiosynovectomy.
abstract: OBJECTIVE
  In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation.
  
  
  METHODS
  Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 10(13) n.cm(-2).s(-1). The product was converted into chloride form which was further used for labeling of (177)Lu-phytate complex and checked using ITLC (MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (100 µCi/100 µl) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days.
  
  
  RESULTS
  The complex was successfully prepared with high radiochemical purity (>99.9 %). Approximately, the whole injected dose has remained in injection site seven days after injection.
  
  
  CONCLUSIONS
  The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology.
authors.affiliation: Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:14395-836 ; Faculty of Energy Engineering and Physics, Amirkabir University of Technology. Tehran, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Yousefnia
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Jalilian
authors.forename: Ali
authors.initials: A
authors.lastname: Bahrami-Samani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mazidi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghannadi Maragheh
authors.forename: Fereydoun
authors.initials: F
authors.lastname: Abbasi-Davani
keywords: Biodistribution; Lutetium-177; Phytate Radiosynovectomy