title: The effect of anaesthesia technique on maternal and cord blood ischaemia-modified albumin levels during caesarean section: a randomized controlled study.
abstract: OBJECTIVE
  Ischaemia-modified albumin (IMA) is an early marker for various ischaemic events, including cardiac ischaemia. This study determined variations in IMA levels during caesarean section, performed under general anaesthesia or with combined spinal epidural anaesthesia.
  
  
  METHODS
  Full-term, healthy pregnant women were allocated to undergo caesarean section, using either general anaesthesia or combined spinal epidural anaesthesia. IMA and albumin levels were measured in maternal serum samples taken immediately prior to caesarean section and 30 min into the procedure, as well as from serum taken from cord blood after double clamping.
  
  
  RESULTS
  At total of 51 healthy pregnant women underwent either general anaesthesia (n = 28) or combined spinal epidural anaesthesia (n = 23). Within-group analysis of the general anaesthesia group showed that both IMA levels and IMA/albumin ratios were significantly higher at 30 min of surgery compared with the immediate preoperative period.
  
  
  CONCLUSIONS
  Lower IMA levels in the combined spinal epidural anaesthesia group may have been due to improved balancing of oxidative stress during caesarean section. Further research on IMA levels during caesarean section should take into account the method of anaesthesia used.
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. dilekomur@yahoo.com
authors.forename: Dilek
authors.initials: D
authors.lastname: Omür
authors.forename: Servet Özden
authors.initials: SÖ
authors.lastname: Hacivelioglu
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Oguzalp
authors.forename: Berna
authors.initials: B
authors.lastname: Uyan
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Kiraz
authors.forename: Can
authors.initials: C
authors.lastname: Duman
authors.forename: Funda Kirtay
authors.initials: FK
authors.lastname: Tütüncüler
authors.forename: Volkan
authors.initials: V
authors.lastname: Hanci
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000768:Anesthesia, General / Q000009:adverse effects; D000773:Anesthesia, Obstetrical / Q000379:methods*; D000775:Anesthesia, Spinal; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D011247:Pregnancy; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: Albumin; caesarean section; combined spinal epidural anaesthesia; cord blood; general anaesthesia; ischaemia-modified albumin