title: Catalytic asymmetric tandem Friedel-Crafts alkylation/Michael addition reaction for the synthesis of highly functionalized chromans.
abstract: The enantioselective tandem Friedel-Crafts alkylation/Michael addition reaction of indoles with nitroolefin enoates catalyzed by a diphenylamine-linked bis(oxazoline)-Zn(OTf)2 complex was investigated. This tandem reaction afforded functionalized chiral chromans in good yields with moderate to high stereoselectivities (up to 95:5 dr, up to 99% ee).
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Jiahuan
authors.initials: J
authors.lastname: Peng
authors.forename: Da-Ming
authors.initials: DM
authors.lastname: Du
keywords: Friedel–Crafts alkylation; asymmetric catalysis; bis(oxazoline); chroman; tandem reaction