title: A posttranslational modification cascade drives RAS-induced senescence.
abstract: Posttranslational modifications of TIP60 and PRAK mediate oncogenic RAS-induced senescence.
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000037:antagonists & inhibitors / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D000074443:Lysine Acetyltransferase 5; D048308:Mitogen-Activated Protein Kinase 14 / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D047908:Intracellular Signaling Peptides and Proteins; C111049:MAP-kinase-activated kinase 5; D051548:Histone Acetyltransferases; C098489:KAT5 protein, human; D000074443:Lysine Acetyltransferase 5; D017346:Protein Serine-Threonine Kinases; D048308:Mitogen-Activated Protein Kinase 14; D018631:ras Proteins