title: A comparative analysis of Müller glia-mediated regeneration in the vertebrate retina.
abstract: This article reviews the current state of knowledge regarding the potential of Müller glia to become neuronal progenitor cells in the avian retina. We compare and contrast the remarkable proliferative and neurogenic capacity of Müller glia in the fish retina to the limited capacity of Müller glia in avian and rodent retinas. We summarize recent findings regarding the secreted factors, signaling pathways and cell intrinsic factors that have been implicated in the formation of Müller glia-derived progenitors. We discuss several key similarities and differences between the fish, rodent and chick model systems, highlighting several of the key transcription factors and signaling pathways that regulate the formation of Müller glia-derived progenitors.
authors.affiliation: Department of Neuroscience, College of Medicine, The Ohio State University, 4190 Graves Hall, 333 West 10th Ave, Columbus, OH 43210-1239, USA.
authors.forename: Donika
authors.initials: D
authors.lastname: Gallina
authors.affiliation: Department of Neuroscience, College of Medicine, The Ohio State University, 4190 Graves Hall, 333 West 10th Ave, Columbus, OH 43210-1239, USA.
authors.forename: Levi
authors.initials: L
authors.lastname: Todd
authors.affiliation: Department of Neuroscience, College of Medicine, The Ohio State University, 4190 Graves Hall, 333 West 10th Ave, Columbus, OH 43210-1239, USA. Electronic address: fischer.412@osu.edu.
authors.forename: Andy J
authors.initials: AJ
authors.lastname: Fischer
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D063928:Ependymoglial Cells / Q000502:physiology*; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
keywords: Müller glia; microglia; progenitor; regeneration; retina