title: Management of persons infected with human immunodeficiency virus requiring admission to the intensive care unit.
abstract: Rates of admission to the intensive care unit (ICU) for persons infected with human immunodeficiency virus (HIV) remain relatively unchanged in the modern era despite advances in antiretroviral therapy (ART) and improvements in ICU survival. Critical care may be required for patients with HIV because of severe opportunistic infections or malignancy, antiretroviral drug toxicity, or critical illness seemingly unrelated to HIV, and each of these scenarios may present different management challenges. In this article, the epidemiology of HIV-related ICU admission is reviewed and key management issues are discussed.
authors.affiliation: Division of Infectious Diseases, University Health Network, Faculty of Medicine, University of Toronto, 585 University Avenue, 13 N, Toronto, Ontario M5G 2N2, Canada. darrell.tan@gmail.com
authors.forename: Darrell H S
authors.initials: DH
authors.lastname: Tan
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Walmsley
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D000140:Acidosis, Lactic / Q000139:chemically induced / Q000150:complications; D019380:Anti-HIV Agents / Q000276:immunology / Q000506:poisoning* / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D002318:Cardiovascular Diseases; D015897:Comorbidity; D016638:Critical Illness / Q000628:therapy*; D004342:Drug Hypersensitivity / Q000150:complications; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D006949:Hyperlipidemias; D007362:Intensive Care Units / Q000706:statistics & numerical data; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D018894:Reverse Transcriptase Inhibitors / Q000276:immunology / Q000506:poisoning* / Q000627:therapeutic use; D012720:Severity of Illness Index
chemical_list: D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors
keywords: Antiretroviral toxicity; Critical illness; HIV; ICU; Opportunistic infection