title: The Integrated Web Portal for Escalation with Overdose Control (EWOC).
abstract: In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.
authors.affiliation: Biostatistics & Bioinformatics Research Center, Cedars-Sinai Medical Center, 116 N. Robertson Blvd, Los Angeles, CA 90048, USA.
authors.forename: Haibin
authors.initials: H
authors.lastname: Wang
authors.forename: Mourad
authors.initials: M
authors.lastname: Tighiouart
authors.forename: Shao-Chi
authors.initials: SC
authors.lastname: Huang
authors.forename: Dror
authors.initials: D
authors.lastname: Berel
authors.forename: Galen
authors.initials: G
authors.lastname: Cook-Wiens
authors.forename: Catherine
authors.initials: C
authors.lastname: Bresee
authors.forename: Quanlin
authors.initials: Q
authors.lastname: Li
authors.forename: André
authors.initials: A
authors.lastname: Rogatko
keywords: Bayesian method; EWOC; cancer phase I clinical trial; maximum tolerated dose; open source.