title: [Hydroa vacciniforme-like lymphoma: two cases report and literatures review].
abstract: OBJECTIVE
  Two children with hydroa vacciniforme-like lymphoma (HVLL) were reported for a better understanding of this disease.
  
  
  METHODS
  The clinical manifestation, pathological characteristics, therapeutic outcomes of two children with HVLL were analyzed and presented by compared with what described in literatures.
  
  
  RESULTS
  Two children were girls, who treated firstly in the hospital in May 2012, July 2012 and their duration were 1 years, more than 10 years respectively. Their clinical manifestations were both limbs and craniofacial polymorphous rashes. Pathological findings revealed that the dermis and subcutaneous tissue were profiled by atypical lymphocytic infiltration. Immunohistochemistry showed that the infiltration of cells from T/NK cell, and Epstein-Barr virus encoded small RNA (EBER)(+). Case 1 was treated with chemotherapy, but her condition continued to deteriorate. Case 2 just received symptomatic treatment, her skin lesions gradually reduced and rash disappeared completely 2 months later.
  
  
  CONCLUSIONS
  HVLL is found with special clinical manifestation, its diagnosis mainly depend on skin biopsy and immunohistochemistry, there is no specific treatment method now, and its prognosis still needs further research.
authors.affiliation: Department of Pediatric Hematology and Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: Xue-ju
authors.initials: XJ
authors.lastname: Xu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Huan-huan
authors.initials: HH
authors.lastname: Li
authors.forename: Shuang
authors.initials: S
authors.lastname: Wu
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Li
authors.forename: Wen-cai
authors.initials: WC
authors.lastname: Li
authors.forename: Yu-qiong
authors.initials: YQ
authors.lastname: Liu
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006837:Hydroa Vacciniforme; D016410:Lymphoma, T-Cell, Cutaneous; D012878:Skin Neoplasms