title: Neurovascular abnormalities in brain disorders: highlights with angiogenesis and magnetic resonance imaging studies.
abstract: The coupling between neuronal activity and vascular responses is controlled by the neurovascular unit (NVU), which comprises multiple cell types. Many different types of dysfunction in these cells may impair the proper control of vascular responses by the NVU. Magnetic resonance imaging, which is the most powerful tool available to investigate neurovascular structures or functions, will be discussed in the present article in relation to its applications and discoveries. Because aberrant angiogenesis and vascular remodeling have been increasingly reported as being implicated in brain pathogenesis, this review article will refer to this hallmark event when suitable.
authors.affiliation: Institute of Biomedical Sciences, Academic Sinica, Taipei 11529, Taiwan.
authors.forename: Chiao-Chi V
authors.initials: CC
authors.lastname: Chen
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Chen
authors.forename: Han-Yun
authors.initials: HY
authors.lastname: Hsiao
authors.forename: Chen
authors.initials: C
authors.lastname: Chang
authors.forename: Yijuang
authors.initials: Y
authors.lastname: Chern
mesh_terms: D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D001927:Brain Diseases / Q000473:pathology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging; D009389:Neovascularization, Pathologic / Q000473:pathology