title: Inherently electroactive graphene oxide nanoplatelets as labels for specific protein-target recognition.
abstract: Graphene related materials have been widely employed as highly efficient transducers for biorecognition. Here we show a conceptually new approach of using graphene oxide nanoplatelets (50 × 50 nm) as voltammetric inherently active labels for specific protein-target molecule recognition. This proof-of-principle is demonstrated by biotin-avidin recognition, which displays that graphene oxide nanoplatelet labels show excellent selectivity. Therefore, it is expected that inherently electroactive graphene oxide nanoplatelet labels will play a similar role as electroactive gold nanoparticle labels which were developed more than a decade ago.
authors.affiliation: Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
authors.forename: Adeline Huiling
authors.initials: AH
authors.lastname: Loo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bonanni
authors.forename: Martin
authors.initials: M
authors.lastname: Pumera
mesh_terms: D001360:Avidin / Q000032:analysis* / Q000378:metabolism; D001710:Biotin / Q000737:chemistry / Q000378:metabolism; D015342:DNA Probes / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry
chemical_list: D015342:DNA Probes; D010087:Oxides; D001360:Avidin; D001710:Biotin; D006046:Gold; D006108:Graphite