title: Watchful waiting for some children with a mediastinal mass: the potential role for ¹⁸F-fluorodeoxyglucose positron emission tomography: a case report and review of the literature.
abstract: BACKGROUND
  Benign hyperplastic thymus is a rare but important differential diagnosis of anterior mediastinal lesions. Histological and radiological criteria are used to distinguish this benign condition from other malignant diseases but have their limitations, and biopsy of mediastinal masses can be risky. We report for the first time the diagnostic value of fluorodeoxyglucose 18F positron emission tomography for patients with incidentally identified anterior mediastinal masses to avoid biopsy in some cases.
  
  
  METHODS
  A 2 year old girl presented with new onset of emesis and constipation leading to the incidental discovery of an anterior mediastinal mass on radiograph. Chest computed tomography revealed cystic components within the mass concerning for a malignancy. Biopsy of the lesion and bone marrow aspiration and biopsy were negative but there was concern that the mediastinal biopsy may have missed the malignant component of the lesion. Hence, a positron emission tomography scan was obtained that showed mild homogeneous fluorodeoxyglucose 18F avidity within the mass similar to that of normal thymus. The diagnosis of benign hyperplastic thymus was made.
  
  
  CONCLUSIONS
  The differential diagnosis of an incidentally found anterior mediastinal mass includes malignancy, but benign lesions such as benign hyperplastic thymus must also be considered, particularly when the complete blood count and biochemical profile are normal. Fluorodeoxyglucose 18F positron emission tomography can help guide a clinician's decision for further interventions and treatment.
authors.forename: Rosa
authors.initials: R
authors.lastname: Nguyen
authors.forename: Jamie L
authors.initials: JL
authors.lastname: Coleman
authors.forename: Scott C
authors.initials: SC
authors.lastname: Howard
authors.forename: Monika L
authors.initials: ML
authors.lastname: Metzger
mesh_terms: D001706:Biopsy; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008479:Mediastinal Neoplasms / Q000175:diagnosis; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013952:Thymus Hyperplasia / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D057832:Watchful Waiting
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18