title: The effectiveness comparison of Jitai tablets versus methadone in community-based drug treatment: a 1-year follow-up study.
abstract: OBJECTIVE
  The aim of the study was to compare the effectiveness of Jitai tablets (JTT) versus methadone in a community drug treatment program.
  
  
  METHODS
  A cohort study was conducted with 386 eligible subjects from 7 districts to 65 communities in Shanghai. The subjects were placed into the JTT group (n=206) or the methadone group (n=180). The data were collected at 8-, 26- and 52-week follow-ups.
  
  
  RESULTS
  The retention rates of the methadone group at the 8-, 26-, and 52-week follow-ups were 97.78%, 91.67%, and 85.00%, respectively. The retention rates of the JTT group at these follow-ups were 90.78%, 83.50%, and 74.27%, respectively. A Chi-square test indicated a significant difference, and the P values were 0.0037, 0.0161, and 0.0095 for each follow-up. The relapse rates for the JTT group were 3.88%, 6.31% and 11.17% for each follow-up, and those for the methadone group were 1.11%, 2.78%, and 7.78% for each follow-up. The Chi-square test indicated no significance, and the P values were 0.1128, 0.1005 and 0.2594. A survival analysis indicated that the relapse survival curve had no significant difference between the two groups (log-rank test, P=0.188).
  
  
  CONCLUSIONS
  Methadone and JTT combined with psychological intervention and social support provided effective maintenance treatment and relapse prevention in a community drug treatment program. The retention rate in the methadone group was higher, but the JTT group had the same relapse prevention as the methadone group. JTT can be recommended to clinical doctors and drug addicts.
authors.affiliation: School of Public Health, Fudan University, Shanghai, China. 10111020024@fudan.edu.cn
authors.forename: Shen-Qiang
authors.initials: SQ
authors.lastname: Hao
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Rui-Wen
authors.initials: RW
authors.lastname: Zhang
authors.forename: Jian-Chen
authors.initials: JC
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xue-Shan
authors.initials: XS
authors.lastname: Feng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002681:China; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003153:Community Health Services; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D058850:Opiate Substitution Treatment; D010349:Patient Compliance / Q000706:statistics & numerical data; D011358:Product Surveillance, Postmarketing; D055502:Secondary Prevention; D012944:Social Support; D016019:Survival Analysis; D013607:Tablets; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013607:Tablets; D008691:Methadone
keywords: Chinese medicine; Community-based drug treatment; Jitai tablet; Methadone; Relapse prevention; Retention rate