title: Does preoperative portal vein embolization have any impact on the outcome of right-side hepatectomy for Klatskin tumor?
abstract: OBJECTIVE
  The clinical usefulness of portal vein embolization (PVE) for Klatskin tumor is not well established. The authors explored the change in liver volume and function before and after major hepatectomy and evaluated the effect of PVE.
  
  
  METHODS
  Thirty-three consecutive patients who underwent right hepatectomy with an initial future liver remnant (FLR) ≤ 30% for Klatskin tumors at Seoul National University Hospital were included.
  
  
  RESULTS
  Eleven patients underwent PVE, and eight patients received right trisectionectomy. PVE induced a mean FLR increase of 19.3% after a mean of 15.8 days. At postoperative month 1, liver volume and liver hypertrophy ratio was comparable between PVE and no-PVE group. For patients with an initial FLR ≤ 20%, postoperative liver hypertrophy rate of PVE group was comparable to no-PVE group. Liver function tests were not affected by PVE or the initial FLR. Postoperative liver hypertrophy ratio was negatively correlated with the initial FLR (hypertrophy ratio (%) = 326.7-0.4×initial FLR (ml), P = 0.001). There was no severe PVE-related morbidity, and postoperative morbidity rate was comparable in PVE and no-PVE group.
  
  
  CONCLUSIONS
  The postoperative liver hypertrophy ratio, final liver volume, or liver function tests were not affected by PVE. Postoperative liver hypertrophy was related to the initial FLR.
authors.affiliation: Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea.
authors.forename: Mee Joo
authors.initials: MJ
authors.lastname: Kang
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Jang
authors.forename: Wooil
authors.initials: W
authors.lastname: Kwon
authors.forename: Jae Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Ye Rim
authors.initials: YR
authors.lastname: Chang
authors.forename: Sun-Whe
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000601:surgery*; D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy / Q000379:methods; D006500:Hepatic Duct, Common; D006529:Hepatomegaly / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D018285:Klatskin Tumor / Q000601:surgery*; D016014:Linear Models; D008099:Liver / Q000254:growth & development / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011169:Portal Vein; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D011300:Preoperative Care / Q000379:methods*; D016896:Treatment Outcome