title: Neuronal expression of fibroblast growth factor receptors in zebrafish.
abstract: Fibroblast growth factor (FGF) signaling is important for a host of developmental processes such as proliferation, differentiation, tissue patterning, and morphogenesis. In vertebrates, FGFs signal through a family of four fibroblast growth factor receptors (FGFR 1-4), one of which is duplicated in zebrafish (FGFR1). Here we report the mRNA expression of the five known zebrafish fibroblast growth factor receptors at five developmental time points (24, 36, 48, 60, and 72h postfertilization), focusing on expression within the central nervous system. We show that the receptors have distinct and dynamic expression in the developing zebrafish brain, eye, inner ear, lateral line, and pharynx. In many cases, the expression patterns are similar to those of homologous FGFRs in mouse, chicken, amphibians, and other teleosts.
authors.affiliation: Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, University of Calgary, Canada.
authors.forename: Patricia
authors.initials: P
authors.lastname: Rohs
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Ebert
authors.forename: Ania
authors.initials: A
authors.lastname: Zuba
authors.forename: Sarah
authors.initials: S
authors.lastname: McFarlane
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D009474:Neurons / Q000378:metabolism*; D009928:Organ Specificity; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics / Q000378:metabolism; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics / Q000378:metabolism; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics / Q000378:metabolism; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000235:genetics / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism*
chemical_list: D051496:Receptor, Fibroblast Growth Factor, Type 1; D051497:Receptor, Fibroblast Growth Factor, Type 2; D051498:Receptor, Fibroblast Growth Factor, Type 3; D051499:Receptor, Fibroblast Growth Factor, Type 4
keywords: Danio rerio; Development; Embryonic; FGF; FGFR; Hpf; fibroblast growth factor; fibroblast growth factor receptor; hours postfertilization; mRNA expression