title: Electrocatalytical oxidation and sensitive determination of acetaminophen on glassy carbon electrode modified with graphene-chitosan composite.
abstract: The electrochemical behaviors of acetaminophen (ACOP) on a graphene-chitosan (GR-CS) nanocomposite modified glassy carbon electrode (GCE) were investigated by cyclic voltammetry (CV), chronocoulometry (CC) and differential pulse voltammetry (DPV). Electrochemical characterization showed that the GR-CS nanocomposite had excellent electrocatalytic activity and surface area effect. As compared with bare GCE, the redox signal of ACOP on GR-CS/GCE was greatly enhanced. The values of electron transfer rate constant (ks), diffusion coefficient (D) and the surface adsorption amount (Γ(*)) of ACOP on GR-CS/GCE were determined to be 0.25s(-1), 3.61×10(-5) cm(2) s(-1) and 1.09×10(-9) mol cm(-2), respectively. Additionally, a 2e(-)/2H(+) electrochemical reaction mechanism of ACOP was deduced based on the acidity experiment. Under the optimized conditions, the ACOP could be quantified in the range from 1.0×10(-6) to 1.0×10(-4) M with a low detection limit of 3.0×10(-7) M based on 3S/N. The interference and recovery experiments further showed that the proposed method is acceptable for the determination of ACOP in real pharmaceutical preparations.
authors.affiliation: Department of Chemistry and Environmental Science, Zhangzhou Normal University, Zhangzhou 363000, China.
authors.forename: Meixia
authors.initials: M
authors.lastname: Zheng
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Qingxiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Xili
authors.initials: X
authors.lastname: Cai
authors.forename: Shulian
authors.initials: S
authors.lastname: Jiang
authors.forename: Lizhang
authors.initials: L
authors.lastname: Huang
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D048271:Chitosan / Q000737:chemistry*; D004058:Diffusion; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D004583:Electrons; D005898:Glass / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D012996:Solutions; D013997:Time Factors
chemical_list: D012996:Solutions; D000082:Acetaminophen; D002244:Carbon; D006108:Graphite; D048271:Chitosan
keywords: Acetaminophen; Determination; Electrochemistry; Graphene–chitosan composite