title: Impact on ART initiation of point-of-care CD4 testing at HIV diagnosis among HIV-positive youth in Khayelitsha, South Africa.
abstract: BACKGROUND
  Despite the rapid expansion of antiretroviral therapy (ART) programmes in developing countries, pre-treatment losses from care remain a challenge to improving access to treatment. Youth and adolescents have been identified as a particularly vulnerable group, at greater risk of loss from both pre-ART and ART care. Point-of-care (POC) CD4 testing has shown promising results in improving linkage to ART care. In Khayelitsha township, South Africa, POC CD4 testing was implemented at a clinic designated for youth aged 12-25 years. We assessed whether there was an associated reduction in attrition between HIV testing, assessment for eligibility and ART initiation.
  
  
  METHODS
  A before-and-after observational study was conducted using routinely collected data. These were collected on patients from May 2010 to April 2011 (Group A) when baseline CD4 count testing was performed in a laboratory and results were returned to the clinic within two weeks. Same-day POC CD4 testing was implemented in June 2011, and data were collected on patients from August 2011 to July 2012 (Group B).
  
  
  RESULTS
  A total of 272 and 304 youth tested HIV-positive in Group A and Group B, respectively. Group B patients were twice as likely to have their ART eligibility assessed compared to Group A patients: 275 (90%) vs. 183 (67%) [relative risk (RR)=2.4, 95% CI: 1.8-3.4, p<0.0001]. More patients in World Health Organization (WHO) Stage 1 disease (85% vs. 69%), with CD4 counts≥350 cells/µL (58% vs. 35%) and more males (13% vs. 7%) were detected in Group B. The proportion of eligible patients who initiated ART was 50% and 44% (p=0.6) in Groups B and A, respectively; and 50% and 43% (p=0.5) when restricted to patients with baseline CD4 count≤250 cells/µL. Time between HIV-testing and ART initiation was reduced from 36 to 28 days (p=0.6).
  
  
  CONCLUSIONS
  POC CD4 testing significantly improved assessment for ART eligibility. The improvement in the proportion initiating ART and the reduction in time to initiation was not significant due to sample size limitations.
  
  
  CONCLUSIONS
  POC CD4 testing reduced attrition between HIV-testing and assessment of ART eligibility. Strategies to improve uptake of ART are needed, possibly by improving patient support for HIV-positive youth immediately after diagnosis.
authors.affiliation: MSF Khayelitsha, Cape Town, South Africa. gem.patten@gmail.com
authors.forename: Gabriela E M
authors.initials: GE
authors.lastname: Patten
authors.forename: Lynne
authors.initials: L
authors.lastname: Wilkinson
authors.forename: Karien
authors.initials: K
authors.lastname: Conradie
authors.forename: Petros
authors.initials: P
authors.lastname: Isaakidis
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Harries
authors.forename: Mary E
authors.initials: ME
authors.lastname: Edginton
authors.forename: Virginia
authors.initials: V
authors.lastname: De Azevedo
authors.forename: Gilles
authors.initials: G
authors.lastname: van Cutsem
mesh_terms: D000553:Ambulatory Care / Q000379:methods* / Q000458:organization & administration*; D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D018791:CD4 Lymphocyte Count / Q000379:methods; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D019095:Point-of-Care Systems; D011247:Pregnancy; D013019:South Africa; D013997:Time Factors; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents
keywords: HIV/AIDS; South Africa; antiretroviral therapy; attrition; operational research; point-of-care CD4 testing; pre-antiretroviral therapy care; youth and adolescents