title: Chemokine receptor-like 2 is involved in ischemic brain injury.
abstract: We examined the role of CCRL2 in ischemic brain injury using bothin vitroandin vivomouse stroke models. The expression of CCRL2 was enhanced at both the RNA and protein levels in cultured brain slices under ischemic conditions. Ischemia-induced cell death was reduced in brain slices derived from CCRL2 knockout (KO) mice in comparison with those from wild type (WT) mice. The infarct volume was smaller and neurological deficits were attenuated in CCRL2 KO mice when compared to WT mice subjected to a transient middle cerebral artery occlusion. Our data suggest that CCRL2 is involved in ischemia-induced brain injury in mice.
authors.affiliation: Department of Pediatrics, University of California-San Diego, La Jolla, CA 92093.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Douglas
authors.forename: Alice H
authors.initials: AH
authors.lastname: Chen
authors.forename: Alejandra
authors.initials: A
authors.lastname: Iniguez
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Zhengxing
authors.initials: Z
authors.lastname: Fu
authors.forename: Frank L
authors.initials: FL
authors.lastname: Powell
authors.forename: Gabriel G
authors.initials: GG
authors.lastname: Haddad
authors.forename: Hang
authors.initials: H
authors.lastname: Yao