title: [Bisphosphonate-associated osteonecrosis of the jaws in lung cancer patients].
abstract: Osteonecrosis of the jaw (ONJ) can occur as a complication of bisphosphonate therapy. This condition has been described in cancer patients and its development has been associated with prolonged exposure to high doses of bisphosphonates. Bad dental hygiene, a history of prosthesis or dental extraction, chemotherapy, corticosteroids, and radiation therapy of the head and neck are risk factors reported. In the initial stages it may be asymptomatic, but the patient subsequently develops severe pain and progressive exposed bone. The authors describe three cases of ONJ in lung cancer patients after prolonged exposure to bisphosphonates and there were known risk factors. ONJ can seriously affect the quality of life of cancer patients. An early diagnosis may reduce or avoid the consequences of progressive bone lesion.
authors.affiliation: Departamento de Pneumologia, Centro Hospitalar de São João, EPE - Porto, Porto, Portugal. Electronic address: inesneves.porto@gmail.com.
authors.forename: Inês
authors.initials: I
authors.lastname: Neves
authors.forename: António
authors.initials: A
authors.lastname: Morais
authors.forename: Adriana
authors.initials: A
authors.lastname: Magalhães
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000209:etiology*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: Bisphosphonate-associated osteonecrosis of the jaw; Cancro do pulmão; Fatores de risco; Lung cancer; Osteonecrose da mandíbula associada aos bifosfonatos; Risk factors; Therapy; Tratamento