title: [Propofol up2date. Part 1: history and pharmacological characteristics].
abstract: Propofol is a common hypnotic agent in anaesthesiology and intensive care medicine and for procedural sedation as well. Despite the intensive usage the full potential, pharmacokinetic and -dynamic abilities, interactions and side effects of the substance may not be realized by all providers. Additionally there is dispute and unwarranted myth about the substance. Propofol is a highly potent hypnotic with a wide range of (un)desired effects. This article is reviewing the diversity of the substance in clinical practice.
authors.affiliation: Instituts für Anästhesiologie,Intensivmedizin, Notfallmedizin und Schmerztherapie am Hegau-Bodensee-Klinikum Singen. stefan.bushuven@hbh-kliniken.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Bushuven
authors.forename: Daniel
authors.initials: D
authors.lastname: Heise
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000266:history* / Q000493:pharmacokinetics / Q000494:pharmacology*; D000932:Antiemetics; D002203:Capital Punishment; D016292:Procedural Sedation; D000075202:Contraindications; D004340:Drug Contamination / Q000517:prevention & control; D004492:Edetic Acid; D004655:Emulsions; D005079:Excipients; D005858:Germany; D006439:Hemodynamics / Q000187:drug effects; D049673:History, 20th Century; D006801:Humans; D007155:Immunologic Factors; D015742:Propofol / Q000008:administration & dosage / Q000266:history* / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D018686:Anesthetics, Intravenous; D000932:Antiemetics; D004655:Emulsions; D005079:Excipients; D007155:Immunologic Factors; D004492:Edetic Acid; D015742:Propofol