title: Nutrient sensing and metabolic stress pathways in innate immunity.
abstract: Cells monitor nutrient availability through several highly conserved pathways that include the mTOR signalling axis regulated by AKT/PI3K, HIF and AMPK, as well as the GCN2/eIF2α integrated stress response pathway that provides cellular adaptation to amino acid starvation. Recent evidence has identified a critical interplay between these nutrient sensing pathways and innate immunity to bacterial pathogens, viruses and parasites. These observations suggest that, in addition to the well-characterized pro-inflammatory signalling mediated by pattern recognition molecules, a metabolic stress programme contributes to shape the global response to pathogens.
authors.affiliation: Department of Laboratory Medicine and Pathobiologyy, University of Toronto, Toronto, M5S 1A8, Canada.
authors.forename: Jessica
authors.initials: J
authors.lastname: Tsalikis
authors.forename: David O
authors.initials: DO
authors.lastname: Croitoru
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Philpott
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Girardin
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D053263:Gene Regulatory Networks; D007113:Immunity, Innate; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D000596:Amino Acids