title: TB: the Yin and Yang of lipid mediators.
abstract: There is a growing appreciation of the diverse roles that lipid mediators play in modulating inflammatory responses during infection. In the case of tuberculosis, virulent mycobacteria induce host production of anti-inflammatory mediators, including lipoxins, which limit the host inflammatory response and lead to necrotic cell death of infected macrophages. Recent work using the zebrafish model suggests that, while excess anti-inflammatory lipoxins are host detrimental during mycobacterial infections, excess pro-inflammatory lipids also drive host susceptibility. The balance of these inflammatory states is influenced by common human genetic variation in Asia. Fuller understanding of the mechanisms of eicosanoid-mediated inflammatory imbalance during tuberculosis infection has important implications for the development of adjunctive therapies.
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA. david.tobin@duke.edu
authors.forename: David M
authors.initials: DM
authors.lastname: Tobin
authors.forename: Lalita
authors.initials: L
authors.lastname: Ramakrishnan
mesh_terms: D000818:Animals; D004851:Epoxide Hydrolases / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology*; D044045:Lipoxins / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators; D044045:Lipoxins; D004851:Epoxide Hydrolases; C043134:leukotriene A4 hydrolase