title: Linking MLL Leukemia with Integrin Signaling.
abstract: Identification of tractable signaling molecules essential for leukemogenesis facilitates the development of effective targeted therapies. In this issue of Cancer Cell, Miller and colleagues report that Integrin Beta 3, which is largely dispensable for normal hematopoiesis, plays an important role and is a potential therapeutic target in mixed lineage leukemia.
authors.affiliation: Leukaemia and Stem Cell Biology Group, Department of Haematological Medicine, King's College London, London SE5 9NU, UK.
authors.forename: Bernd B
authors.initials: BB
authors.lastname: Zeisig
authors.forename: Chi Wai Eric
authors.initials: CW
authors.lastname: So
mesh_terms: D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D039661:Integrin beta3 / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000502:physiology*; D015514:Oncogene Proteins, Fusion / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D000072377:Syk Kinase
chemical_list: D039661:Integrin beta3; D047908:Intracellular Signaling Peptides and Proteins; C497422:KMT2A protein, human; C474558:MLL-AF9 fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase