title: Awake language mapping and 3-Tesla intraoperative MRI-guided volumetric resection for gliomas in language areas.
abstract: The use of both awake surgery and intraoperative MRI (iMRI) has been reported to optimize the maximal safe resection of gliomas. However, there has been little research into combining these two demanding procedures. We report our unique experience with, and methodology of, awake surgery in a movable iMRI system, and we quantitatively evaluate the contribution of the combination on the extent of resection (EOR) and functional outcome of patients with gliomas involving language areas. From March 2011 to November 2011, 30 consecutive patients who underwent awake surgery with iMRI guidance were prospectively investigated. The EOR was assessed by volumetric analysis. Language assessment was conducted before surgery and 1 week, 1 month, 3 months and 6 months after surgery using the Aphasia Battery of Chinese. Awake language mapping integrated with 3.0 Tesla iMRI was safely performed for all patients. An additional resection was conducted in 11 of 30 patients (36.7%) after iMRI. The median EOR significantly increased from 92.5% (range, 75.1-97.0%) to 100% (range, 92.6-100%) as a result of iMRI (p<0.01). Gross total resection was achieved in 18 patients (60.0%), and in seven of those patients (23.3%), the gross total resection could be attributed to iMRI. A total of 12 patients (40.0%) suffered from transient language deficits; however, only one (3.3%) patient developed a permanent deficit. This study demonstrates the potential utility of combining awake craniotomy with iMRI; it is safe and reliable to perform awake surgery using a movable iMRI.
authors.affiliation: Division of Glioma Surgery, Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Lu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Wu
authors.forename: Chengjun
authors.initials: C
authors.lastname: Yao
authors.forename: Dongxiao
authors.initials: D
authors.lastname: Zhuang
authors.forename: Tianming
authors.initials: T
authors.lastname: Qiu
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Hu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiu
authors.initials: X
authors.lastname: Gong
authors.forename: Weimin
authors.initials: W
authors.lastname: Liang
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Liangfu
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D038361:Neuronavigation / Q000379:methods; D011446:Prospective Studies; D014851:Wakefulness / Q000502:physiology; D055815:Young Adult
keywords: Awake surgery; Direct electrical stimulation; Glioma; Intraoperative MRI; Volumetric analysis