title: Witnessed sleep-related seizure and sudden unexpected death in infancy: a case report.
abstract: Witnessed reports of sudden death are rare, but critical to deciphering its mechanism(s). We report such a death in a seemingly healthy 8-month-old boy in whom seizures and respiratory distress in the prone position were witnessed upon discovery during a sleep period. Following cardiopulmonary resuscitation, anoxic encephalopathy resulted in "brain death" and withdrawal of life support after 2 days. The autopsy did not reveal a primary anatomic cause of death. Metabolic evaluation failed to uncover an inborn error of ammonia, amino, organic, or fatty acid metabolism. Seizures in this case may have been secondary to cerebral hypoxia-ischemia complicating cardiorespiratory arrest of unknown etiology. Yet, they may represent the first manifestation of idiopathic epilepsy, triggering cardiopulmonary arrest, analogous to the terminal events postulated in sudden and unexplained death in epilepsy. This report alerts the forensic community to the possibility that sudden and unexplained death in infants may be due to seizures.
authors.affiliation: Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Hannah.kinney@childrens.harvard.edu
authors.forename: Hannah C
authors.initials: HC
authors.lastname: Kinney
authors.forename: Anna G
authors.initials: AG
authors.lastname: McDonald
authors.forename: Megan E
authors.initials: ME
authors.lastname: Minter
authors.forename: Gerard T
authors.initials: GT
authors.lastname: Berry
authors.forename: Annapurna
authors.initials: A
authors.lastname: Poduri
authors.forename: Richard D
authors.initials: RD
authors.lastname: Goldstein
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001344:Autopsy; D016887:Cardiopulmonary Resuscitation; D002423:Cause of Death; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D008297:Male; D016684:Prone Position; D012120:Respiration Disorders / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D012640:Seizures / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D012890:Sleep; D013398:Sudden Infant Death / Q000209:etiology* / Q000473:pathology
chemical_list: D000927:Anticonvulsants