title: Coincidence of ischemic stroke and recurrent brain haemorrhage in a patient with Klippel-Trenaunay Syndrome.
abstract: Cerebrovascular manifestations in Klippel-Trenaunay Syndrome (KTS) have been reported but are extremely rare. Case reports describe brain embolism in KTS-associated coagulopathy as well as bleeding due to arteriovenous malformations. We describe a 45-year-old patient with KTS and both acute ischemic stroke and repeated cerebral haemorrhage. The underlying aetiology of both events remained undetermined despite extensive diagnostic work-up, including coagulation tests and dynamic MR angiography. It is most likely that both a pathological coagulation and increased vessel fragility comparable to amyloid angiopathy were responsible for the combined brain lesions in this patient. We conclude that KTS is a very rare but relevant aetiology of cerebral ischemia and that anticoagulation treatment in these cases should be carefully considered as the risk of cerebral haemorrhage is probably elevated.
authors.affiliation: Department of Neurology, University Hospital Freiburg, Breisacherstrasse 64, Freiburg 79106, Germany. Electronic address: lena.beume@uniklinik-freiburg.de.
authors.forename: Lena A
authors.initials: LA
authors.lastname: Beume
authors.forename: Silke C
authors.initials: SC
authors.lastname: Fuhrmann
authors.forename: Matthias
authors.initials: M
authors.lastname: Reinhard
authors.forename: Andreas
authors.initials: A
authors.lastname: Harloff
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007715:Klippel-Trenaunay-Weber Syndrome / Q000150:complications* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000150:complications* / Q000175:diagnosis
chemical_list: D000959:Antihypertensive Agents
keywords: Amyloid angiopathy; Intracerebral bleeding; Ischemic stroke; Klippel-Trenaunay Syndrome