title: A new hydroxyapatite-based biocomposite for bone replacement.
abstract: Since the 1970s, various types of ceramic, glass and glass-ceramic materials have been proposed and used to replace damaged bone in many clinical applications. Among them, hydroxyapatite (HA) has been successfully employed thanks to its excellent biocompatibility. On the other hand, the bioactivity of HA and its reactivity with bone can be improved through the addition of proper amounts of bioactive glasses, thus obtaining HA-based composites. Unfortunately, high temperature treatments (1200°C÷1300°C) are usually required in order to sinter these systems, causing the bioactive glass to crystallize into a glass-ceramic and hence inhibiting the bioactivity of the resulting composite. In the present study novel HA-based composites are realized and discussed. The samples can be sintered at a relatively low temperature (800 °C), thanks to the employment of a new glass (BG_Ca) with a reduced tendency to crystallize compared to the widely used 45S5 Bioglass®. The rich glassy phase, which can be preserved during the thermal treatment, has excellent effects in terms of in vitro bioactivity; moreover, compared to composites based on 45S5 Bioglass® having the same HA/glass proportions, the samples based on BG_Ca displayed an earlier response in terms of cell proliferation.
authors.affiliation: Department of Engineering Enzo Ferrari, University of Modena and Reggio Emilia, Via Vignolese 905, 41125 Modena, Italy. devis.bellucci@unimore.it
authors.forename: Devis
authors.initials: D
authors.lastname: Bellucci
authors.forename: Antonella
authors.initials: A
authors.lastname: Sola
authors.forename: Matteo
authors.initials: M
authors.lastname: Gazzarri
authors.forename: Federica
authors.initials: F
authors.lastname: Chiellini
authors.forename: Valeria
authors.initials: V
authors.lastname: Cannillo
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry; D017886:Durapatite / Q000494:pharmacology*; D005898:Glass / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D013052:Spectrometry, X-Ray Emission; D013059:Spectrum Analysis, Raman; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; C425330:bioactive glass 45S5; D017886:Durapatite; D000469:Alkaline Phosphatase
keywords: Bioceramics; Bone tissue engineering; Composites; Glass–ceramics; Hydroxyapatite