title: Oxidative stress in freshwater fish, Labeo rohita as a biomarker of malathion exposure.
abstract: This study examined the effect of lethal (4.5 μg/l) and sublethal (0.45 μg/l) malathion levels on oxidative stress responses of the freshwater edible fish, Labeo rohita. Fish were exposed to lethal (1-4 days) and sublethal (1, 5, 10, and 15 days) periods. In the present study, catalase and protease activity, hydrogen peroxide, malondialdehyde, protein carbonyls, and free amino acids levels increased in the gill, liver, and kidney tissues of fish exposed to lethal and sublethal concentrations of malathion except protein content. Time- and concentration-dependent induction/reduction of the above parameters by lethal and sublethal concentrations of malathion was observed in the tissues (the gill, liver, and kidney) of L. rohita. Thus, the results clearly infer oxidative damage and decline in antioxidant defense due to malathion-induced oxidative stress.
authors.affiliation: Environmental and Molecular Toxicology Laboratory, PG Department of Studies and Research in Zoology, Karnatak University, KUD Staff Qt. B-3, Dharwad, 580003, Karnataka, India.
authors.forename: Vineetkumar K
authors.initials: VK
authors.lastname: Patil
authors.forename: Muniswamy
authors.initials: M
authors.lastname: David
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D003530:Cyprinidae / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods*; D005880:Gills / Q000187:drug effects / Q000378:metabolism; D007306:Insecticides / Q000378:metabolism* / Q000633:toxicity; D008294:Malathion / Q000378:metabolism* / Q000633:toxicity; D018384:Oxidative Stress; D014874:Water Pollutants, Chemical / Q000378:metabolism* / Q000633:toxicity
chemical_list: D015415:Biomarkers; D007306:Insecticides; D014874:Water Pollutants, Chemical; D008294:Malathion