title: The genetics of pro-arrhythmic adverse drug reactions.
abstract: Ventricular arrhythmia induced by drugs (pro-arrythmia) is an uncommon event, whose occurrence is unpredictable but potentially fatal. The ability of a variety of medications to induce these arrhythmias is a significant problem facing the pharmaceutical industry. Genetic variants have been shown to play a role in adverse events and are also known to influence an individual's optimal drug dose. This review provides an overview of the current understanding of the role of genetic variants in modulating the risk of drug induced arrhythmias.
authors.affiliation: Human Genetics Research Centre, Division of Biomedical Sciences, St George's Hospital Medical School, London, SW17 0RE, UK.
authors.forename: Evmorfia
authors.initials: E
authors.lastname: Petropoulou
authors.forename: Yalda
authors.initials: Y
authors.lastname: Jamshidi
authors.forename: Elijah R
authors.initials: ER
authors.lastname: Behr
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000235:genetics*; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D008133:Long QT Syndrome / Q000139:chemically induced / Q000235:genetics*; D012307:Risk Factors; D016171:Torsades de Pointes / Q000139:chemically induced / Q000235:genetics
chemical_list: D000889:Anti-Arrhythmia Agents
keywords: QT interval; adverse drug reactions; genetics; genomics; long QT syndrome; pro-arrhythmia