title: Emerging concepts on the role of exosomes in lipid metabolic diseases.
abstract: Dysregulation of lipid metabolism involves cellular communication mediated by cell contacts or exchange of bioactive lipids bound to soluble carriers or to lipoproteins. An increasing field is that of cellular communication mediated by nanovesicles called exosomes. Those vesicles are released from an internal compartment of viable cells, circulate in all biological fluids and can transfer material from cell-to-cells. Involvement of exosome trafficking in the transcellular metabolism of eicosanoids and cholesterol-related diseases including cancer is developed hereafter.
authors.affiliation: INSERM-UMR 1037, Cancer Research Center of Toulouse (CRCT), Team «Sterol Metabolism and Therapeutic Innovation in Oncology», BP3028, CHU Purpan, Toulouse F-31300, France; Institut Claudius Regaud, 20-24 Rue du Pont Saint-Pierre, 31052 Toulouse Cedex, France; Université Paul Sabatier, 118 Route de Narbonne, Toulouse, France. Electronic address: michel.record@inserm.fr.
authors.forename: Michel
authors.initials: M
authors.lastname: Record
authors.forename: Marc
authors.initials: M
authors.lastname: Poirot
authors.forename: Sandrine
authors.initials: S
authors.lastname: Silvente-Poirot
mesh_terms: D000818:Animals; D001692:Biological Transport; D002450:Cell Communication; D002784:Cholesterol / Q000378:metabolism; D055354:Exosomes / Q000502:physiology*; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism*; D050356:Lipid Metabolism; D008244:Lysophosphatidylcholines / Q000378:metabolism
chemical_list: D008244:Lysophosphatidylcholines; D002784:Cholesterol
keywords: CD36; Cancer; Cholesterol epoxyde hydrolase (CHEH); Docosahexaenoic acid (DHA); Eicosanoids; Phospholipases; Tamoxifen