title: Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention.
abstract: Acute urine retention is a frequent complication in patients with benign hyperplasia of the prostate gland. According to studies made on experimental animals and people, it is accompanied by the deterioration of the bladder blood supply. This study attempts to explore the relationship of intramural blood flow, production of reactive oxygen species, and functional state of the bladder detrusor in modeling of acute urine retention in rats, as well as the impact of mitochondria-targeted antioxidants (which are supposed to alleviate the effects of oxidative stress induced by experimental ischemia) on these parameters. The study showed beneficial effects of mitochondria-targeted antioxidant SkQR1 in preventing damage of the bladder caused by acute urinary retention, which suggests the therapeutic use of this type of compounds for the treatment of ischemic abnormalities of the urinary bladder.
authors.affiliation: Research Institute of Urology, Russian Ministry of Health, 3-ya Parkovaya ul. 51, 105425 Moscow, Russia. vladkirp@yandex.ru
authors.forename: V I
authors.initials: VI
authors.lastname: Kirpatovsky
authors.forename: E Y
authors.initials: EY
authors.lastname: Plotnikov
authors.forename: I S
authors.initials: IS
authors.lastname: Mudraya
authors.forename: S A
authors.initials: SA
authors.lastname: Golovanov
authors.forename: V V
authors.initials: VV
authors.lastname: Drozhzheva
authors.forename: R A
authors.initials: RA
authors.lastname: Khromov
authors.forename: D Y
authors.initials: DY
authors.lastname: Chernikov
authors.forename: V P
authors.initials: VP
authors.lastname: Skulachev
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D012079:Renal Circulation; D001743:Urinary Bladder / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D016055:Urinary Retention / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species