title: Chromatographic background drift correction coupled with parallel factor analysis to resolve coelution problems in three-dimensional chromatographic data: quantification of eleven antibiotics in tap water samples by high-performance liquid chromatography coupled with a diode array detector.
abstract: Chromatographic background drift correction has been an important field of research in chromatographic analysis. In the present work, orthogonal spectral space projection for background drift correction of three-dimensional chromatographic data was described in detail and combined with parallel factor analysis (PARAFAC) to resolve overlapped chromatographic peaks and obtain the second-order advantage. This strategy was verified by simulated chromatographic data and afforded significant improvement in quantitative results. Finally, this strategy was successfully utilized to quantify eleven antibiotics in tap water samples. Compared with the traditional methodology of introducing excessive factors for the PARAFAC model to eliminate the effect of background drift, clear improvement in the quantitative performance of PARAFAC was observed after background drift correction by orthogonal spectral space projection.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Yu
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Wu
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Fu
authors.forename: Juan
authors.initials: J
authors.lastname: Zhao
authors.forename: Yuan-Na
authors.initials: YN
authors.lastname: Li
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Kang
authors.forename: Ru-Qin
authors.initials: RQ
authors.lastname: Yu
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008962:Models, Theoretical
keywords: Antibiotics; Chromatographic background drift correction; Chromatographic peak resolution; PARAFAC; Second-order advantage