title: Dioxin-related compounds in house dust from New York State: occurrence, in vitro toxic evaluation and implications for indoor exposure.
abstract: This study analysed sulphuric-acid-treated extracts of house dust from New York State with DR-CALUX assay and HRGC-HRMS to elucidate the total dioxin-like (DL) activities, the occurrence of various dioxin-related compounds (DRCs), including PBDD/Fs, and their toxic contribution. The DL activities were 30-8000, median 210 pg CALUX-TEQ/g. PCDD/Fs, PBDD/Fs and DL-PCBs were detected with a large variation in concentrations (0.12-80, 0.33-150, 0.46-35, medians 1.7, 2.1 and 5.6 ng/g, respectively) and profiles, indicating the existence of multiple contamination sources in homes. PCDD/Fs, PBDD/Fs and DL-PCBs with known potency theoretically contributed <1%-130%, <1%-21% and <1%-6.8%, respectively, of the measured CALUX-TEQs. These results and those from DR-CALUX assays with fractionated dust extracts indicated that a substantial portion of the CALUX-TEQs could be caused by unknown dust contaminants. Considering that the DRC intake from indoor dust ingestion can be significant, identification of unknown DL contaminants in indoor dust is necessary.
authors.affiliation: Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577, Japan.
authors.forename: Nguyen Minh
authors.initials: NM
authors.lastname: Tue
authors.forename: Go
authors.initials: G
authors.lastname: Suzuki
authors.forename: Shin
authors.initials: S
authors.lastname: Takahashi
authors.forename: Kurunthachalam
authors.initials: K
authors.lastname: Kannan
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Takigami
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tanabe
mesh_terms: D016902:Air Pollution, Indoor / Q000032:analysis* / Q000706:statistics & numerical data; D001572:Benzofurans / Q000032:analysis / Q000633:toxicity; D001681:Biological Assay / Q000379:methods; D004147:Dioxins / Q000032:analysis* / Q000633:toxicity; D004391:Dust / Q000032:analysis*; D004784:Environmental Monitoring; D009518:New York; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000032:analysis / Q000633:toxicity; D011108:Polymers / Q000032:analysis / Q000633:toxicity
chemical_list: D001572:Benzofurans; D004147:Dioxins; D004391:Dust; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; C016068:polychlorodibenzofuran; D011078:Polychlorinated Biphenyls
keywords: Brominated dioxins; CALUX; House dust; PBDEs; TIE