title: Copper-catalyzed enantioselective intramolecular N-arylation, an efficient method for kinetic resolutions.
abstract: For the first time, copper-catalyzed intramolecular N-arylation was successfully applied to the kinetic resolution strategy. Under the catalysis of CuI-BINOL derived ligands, the kinetic resolution of rac-2-amino-3-(2-iodoaryl)propionates and rac-2-amino-4-(2-iodoaryl)butanoates afforded chiral intramolecular coupling products and recovered the starting materials in high enantioselectivity (s factors up to 245).
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No.190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou 510530, China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Long
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhang
authors.forename: Youlin
authors.initials: Y
authors.lastname: Zeng
authors.forename: Qian
authors.initials: Q
authors.lastname: Cai
mesh_terms: D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D007700:Kinetics; D008024:Ligands; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002087:Butyrates; D056831:Coordination Complexes; D008024:Ligands; D011422:Propionates; D003300:Copper