title: [Fertility preservation in children and teenagers with cancer].
abstract: Given the excellent survival rate of children and teenagers treated for cancer, careful should be given in order to minimize long-term late effects of treatments and to improve quality of life. In this regard, fertility preservation is particularly important. Age, sex and concomitant therapies have an impact on the level of risk of hypofertility, with a stronger risk for chemotherapeutic regimens including alkylating agents, and gonads or hypothalamo-pituitary axis radiotherapy. Assessment of gonadotoxic impact of treatment strategy and fertility preservation techniques are crucial for limiting late effects. The objective of this literature review is to develop guidance for pediatric oncologists and hematologists relative to fertility preservation methods, in children and teenagers receiving gonadotoxic treatment. Specific follow-up after treatment is also proposed.
authors.affiliation: Centre Oscar-Lambret, Département de Pédiatrie, 3 Rue Fréderic-Combemale, 59020 Lille cedex, France. h-sudour@o-lambret.fr
authors.forename: Hélène
authors.initials: H
authors.lastname: Sudour-Bonnange
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Tabone
authors.forename: Cécile
authors.initials: C
authors.lastname: Thomas-Teinturier
authors.forename: Hélène
authors.initials: H
authors.lastname: Pacquement
authors.forename: Odile
authors.initials: O
authors.lastname: Oberlin
authors.forename: Perrine
authors.initials: P
authors.lastname: Marec-Berard
authors.forename: Valérie
authors.initials: V
authors.lastname: Laurence
authors.forename: Françoise
authors.initials: F
authors.lastname: Aubier
authors.forename: Lise
authors.initials: L
authors.lastname: Duranteau
authors.forename: Valérie
authors.initials: V
authors.lastname: Bernier-Chastagner
authors.forename: Gérard
authors.initials: G
authors.lastname: Michel
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rives
authors.forename: Claire
authors.initials: C
authors.lastname: Berger
mesh_terms: D000293:Adolescent; D002648:Child; D015925:Cryopreservation / Q000379:methods; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000517:prevention & control; D007248:Infertility, Male / Q000517:prevention & control; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D011788:Quality of Life; D012737:Sex Factors; D017741:Survivors
keywords: cancer; children; fertility preservation; guidelines