title: Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications.
abstract: Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to aging and to predict cancer. Type 2 diabetes (T2D) has been conceptualized as an accelerated-aging disease and is associated with higher prevalence of cancers. Here we aimed to assess the association between T2D and CME occurrence in blood. We evaluated the presence of CMEs in 7,659 individuals (including 2,208 with T2D) using DNA arrays. A significant association between CME occurrence and T2D was found (odds ratio (OR) = 5.3; P = 5.1 × 10(-5)) and was stronger when we only considered non-obese individuals with T2D (OR = 5.6; P = 4.9 × 10(-5)). Notably, CME carriers with T2D had higher prevalence of vascular complications than non-carriers with T2D (71.4% versus 37.1%, respectively; P = 7.7 × 10(-4)). In CME carriers, we found an increase in the percentage of abnormal cells over 6 years (P = 8.60 × 10(-3)). In conclusion, given the increased risk of cancer in CME carriers, our results may have profound clinical implications in patients with severe T2D.
authors.affiliation: Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherche 8199, Lille Pasteur Institute, Lille, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Bonnefond
authors.forename: Boris
authors.initials: B
authors.lastname: Skrobek
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lobbens
authors.forename: Elodie
authors.initials: E
authors.lastname: Eury
authors.forename: Dorothée
authors.initials: D
authors.lastname: Thuillier
authors.forename: Stéphane
authors.initials: S
authors.lastname: Cauchi
authors.forename: Olivier
authors.initials: O
authors.lastname: Lantieri
authors.forename: Beverley
authors.initials: B
authors.lastname: Balkau
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Michel
authors.initials: M
authors.lastname: Marre
authors.forename: Guillaume
authors.initials: G
authors.lastname: Charpentier
authors.forename: Loïc
authors.initials: L
authors.lastname: Yengo
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
mesh_terms: D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D016017:Odds Ratio; D011446:Prospective Studies