title: Casbane diterpenoids from the roots of Euphorbia pekinensis.
abstract: Four casbane diterpenoids, together with three known related compounds were isolated from the roots of Euphorbia pekinensis. Their structures were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. In addition, the absolute configuration of three compounds was determined by the modified Mosher's method. The isolated compounds were evaluated for their cytotoxic activity against seven human cancer cell lines by a WST-8 assay.
authors.affiliation: Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Tao
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.forename: Nian-Yun
authors.initials: NY
authors.lastname: Yang
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Li
authors.forename: Ye-Fei
authors.initials: YF
authors.lastname: Qian
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes
keywords: Cancer cell lines; Casbane diterpenoid; Cytotoxic activity; Euphorbia pekinensis; Euphorbiaceae