title: Effect of copaiba oil in hepatic damage induced by acetaminophen in rats.
abstract: OBJECTIVE
  To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol.
  
  
  METHODS
  Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase, [formula see text] GT, total bilirubin, direct bilirubin and indirect bilirubin and histological analisis were analized.
  
  
  RESULTS
  The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and [formula see text] GT (p>0.05). The therapy copaiba group showed the highest levels of bilirubin and was statistically different from the other groups (p<0.01) and this increased the costs of direct bilirubin. Regarding histopathology, the oil of copaiba administered prophylactic or therapeutic form for 7 days could decrease the amount of necrosis and inflammatory infiltrate.
  
  
  CONCLUSIONS
  Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect.
authors.affiliation: School of Medicine, State University of Para (UEPA), Brazil. renankleberc@hotmail.com
authors.forename: Renan Kleber Costa
authors.initials: RK
authors.lastname: Teixeira
authors.forename: Vitor Nagai
authors.initials: VN
authors.lastname: Yamaki
authors.forename: Edson Yuzur
authors.initials: EY
authors.lastname: Yasojima
authors.forename: Marcus Vinicius Henriques
authors.initials: MV
authors.lastname: Brito
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000818:Animals; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D007887:Fabaceae / Q000737:chemistry*; D008297:Male; D010938:Plant Oils / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D010938:Plant Oils; D000082:Acetaminophen; D001663:Bilirubin