title: A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata.
abstract: OBJECTIVE
  To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata.
  
  
  METHODS
  The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A.
  
  
  RESULTS
  One new homolycorine-type alkaloid 2α-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2α-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6α-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained.
  
  
  CONCLUSIONS
  Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 μg·mL-1 and CC50 values of 14.37, 4.79, and 80.12 μg·mL-1, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Sheng-Dian
authors.initials: SD
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Li
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Duo-Zhi
authors.initials: DZ
authors.lastname: Chen
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Cao
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: DI
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry*; D009980:Influenza A virus / Q000187:drug effects; D031426:Lycoris / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000998:Antiviral Agents; D010936:Plant Extracts
keywords: 2α-Methoxy-6-O-ethyloduline; 2α-Methoxy-6-O-methyloduline; Amaryllidaceae alkaloids; Homolycorine-type; Lycoris radiata