title: [The research progress of Aurora-B kinase and its inhibitors].
abstract: Aurora-B as an important kinase to adjust the cell normal mitosis is a potent target for cancer treatment. Aurora-B is overexpressed in a broad range of tumor and tumor cells are more sensitive while Aurora-B is inhibited. Due to the key role of the Aurora-B in cell mitosis, the development of its inhibitors is becoming more and more important. Several small molecules inhibit with a similar efficacy both Aurora-A and Aurora-B, however, in most cases the effects resemble Aurora-B disruption by genetic methods, indicating that Aurora-B represents an effective therapeutic target. There were several Aurora-B kinase inhibitors which had entered the clinics and displayed good antitumor activity. In this review, we will outline the functions of Aurora kinase B in normal cell division and in malignancy. We will focus on recent preclinical and clinical studies that have explored the mechanism of action and clinical effect of Aurora-B inhibitors in cancer treatment.
authors.affiliation: College of Sciences, Tianjin University of Science and Technology, Tianjin 300457, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Dong
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Xiao
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Zhou
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
mesh_terms: D000818:Animals; D064107:Aurora Kinase B / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D008938:Mitosis; D009369:Neoplasms / Q000188:drug therapy*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D047428:Protein Kinase Inhibitors; D012333:RNA, Messenger; D064107:Aurora Kinase B