title: The locus of microRNA-10b: a critical target for breast cancer insurgence and dissemination.
abstract: Contemporary microRNA research has led to significant advances in our understanding of the process of tumorigenesis. MicroRNAs participate in different events of a cancer cell's life, through their ability to target hundreds of putative transcripts involved in almost every cellular function, including cell cycle, apoptosis, and differentiation. The relevance of these small molecules is even more evident in light of the emerging linkage between their expression and both prognosis and clinical outcome of many types of human cancers. This identifies microRNAs as potential therapeutic modifiers of cancer phenotypes. From this perspective, we overview here the miR-10b locus and its involvement in cancer, focusing on its role in the establishment (miR-10b*) and spreading (miR-10b) of breast cancer. We conclude that targeting the locus of microRNA 10b holds great potential for cancer treatment.
authors.affiliation: Translational Oncogenomics Unit; Regina Elena Italian National Cancer Institute; Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Biagioni
authors.forename: Noa
authors.initials: N
authors.lastname: Bossel Ben-Moshe
authors.forename: Giulia
authors.initials: G
authors.lastname: Fontemaggi
authors.forename: Yosef
authors.initials: Y
authors.lastname: Yarden
authors.forename: Eytan
authors.initials: E
authors.lastname: Domany
authors.forename: Giovanni
authors.initials: G
authors.lastname: Blandino
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000401:mortality / Q000556:secondary / Q000628:therapy; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D056426:Genetic Loci; D006801:Humans; D053208:Kaplan-Meier Estimate; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism
chemical_list: C547183:MIRN10 microRNA, human; D035683:MicroRNAs
keywords: cancer; cell proliferation; miR-10b; miR-10b*; microRNA; therapeutic strategies