title: Clomiphene ovulation induction and higher-order multiple pregnancy.
abstract: Clomiphene citrate is a widely used treatment for ovulatory dysfunction in women seeking pregnancy. The major adverse consequence of clomiphene use is the increased risk of multiple and higher-order multiple pregnancy. Mechanisms for multiple pregnancy include dosing variation, adjuvant therapies, pretreatment weight loss and a cumulative effect of multiple clomiphene cycles. It has been suggested that the risk of higher-order multiple pregnancy may be reduced with ultrasound monitoring, although there is limited evidence to support this practice.
authors.affiliation: Queensland Fertility Group Research Foundation, University of Queensland, Brisbane, Queensland, Australia. simon.mcdowell@hotmail.co.uk
authors.forename: Simon
authors.initials: S
authors.lastname: McDowell
authors.forename: Ben
authors.initials: B
authors.lastname: Kroon
authors.forename: Anusch
authors.initials: A
authors.lastname: Yazdani
mesh_terms: D002996:Clomiphene / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D010062:Ovulation Induction / Q000009:adverse effects*; D011247:Pregnancy; D011272:Pregnancy, Multiple
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene
keywords: clomiphene; higher-order multiple pregnancy; multiple pregnancy; ovulation induction; ovulatory dysfunction