title: Continuous flow, highly enantioselective Michael additions catalyzed by a PS-supported squaramide.
abstract: A polystyrene (PS) supported bifunctional squaramide organocatalyst promotes fast Michael addition of 2-hydroxy-1,4-naphthoquinone to nitroalkenes with very high enantioselectivities at low catalyst loadings. The polystyrene supported catalyst can be recycled up to 10 times without any decrease in enantioselectivity (average 96% ee) and adapted to continuous flow operation (24 h). A single flow experiment involving six different nitroalkenes in a sequential manner highlights the applicability of this methodology for rapid access to chemical diversity.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Pinar
authors.initials: P
authors.lastname: Kasaplar
authors.forename: Carles
authors.initials: C
authors.lastname: Rodríguez-Escrich
authors.forename: Miquel A
authors.initials: MA
authors.lastname: Pericàs