title: Vasoconstriction by electrical stimulation: new approach to control of non-compressible hemorrhage.
abstract: Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be induced in seconds while blood vessels dilated back to their original size within minutes after stimulation. At higher settings, a blood clotting formed, leading to complete and permanent occlusion of the vessels. The latter regime dramatically decreased the bleeding rate in the injured femoral and mesenteric arteries, with a complete hemorrhage arrest achieved within seconds. The average blood loss from the treated femoral artery during the first minute after injury was about 7 times less than that of a non-treated control. This new treatment modality offers a promising approach to non-damaging control of bleeding during surgery, and to efficient hemorrhage arrest in trauma patients.
authors.affiliation: Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94305, USA. yossi.mandel@gmail.com
authors.forename: Yossi
authors.initials: Y
authors.lastname: Mandel
authors.forename: Richard
authors.initials: R
authors.lastname: Manivanh
authors.forename: Roopa
authors.initials: R
authors.lastname: Dalal
authors.forename: Phil
authors.initials: P
authors.lastname: Huie
authors.forename: Jenny
authors.initials: J
authors.lastname: Wang
authors.forename: Mark
authors.initials: M
authors.lastname: Brinton
authors.forename: Daniel
authors.initials: D
authors.lastname: Palanker
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004558:Electric Stimulation; D005263:Femoral Artery / Q000293:injuries / Q000473:pathology; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy; D006801:Humans; D008638:Mesenteric Arteries / Q000293:injuries / Q000473:pathology; D008954:Models, Biological; D051381:Rats; D014661:Vasoconstriction / Q000502:physiology*