title: Pemetrexed-induced eyelid edema in lung cancer.
abstract: Pemetrexed is a novel, multitargeted antifolate approved for the treatment of malignant pleural mesothelioma and non-small cell lung cancer. Although pemetrexed is a safe drug, some adverse effects such as myelosupression and cutaneous reactions are observed. Pemetrexed-induced eyelid edema is a rare side effect of pemetrexed treatment, and until this moment few cases were reported in the medical literature. We reported a new case of pemetrexed-induced eyelid edema in a patient with adenocarcinoma of the lung with brain metastases.
authors.affiliation: Department of Health Education, Federal University of Sergipe, Sergipe, Brazil. pmartins-filho@hotmail.com
authors.forename: Paulo Ricardo Saquete
authors.initials: PR
authors.lastname: Martins-Filho
authors.forename: Simone Yuriko
authors.initials: SY
authors.lastname: Kameo
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Mascarenhas-Oliveira
authors.forename: Nivaldo Farias
authors.initials: NF
authors.lastname: Vieira
authors.forename: Eduardo
authors.initials: E
authors.lastname: Azevedo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D016190:Carboplatin / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced* / Q000188:drug therapy; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D005665:Furosemide / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D005971:Glutamates / Q000009:adverse effects*; D006147:Guanine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D000068437:Pemetrexed; D014805:Vitamin B 12 / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D004232:Diuretics; D005938:Glucocorticoids; D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D005665:Furosemide; D003907:Dexamethasone; D005492:Folic Acid; D016190:Carboplatin; D014805:Vitamin B 12