title: Using therapeutic mammoplasty to extend the role of breast-conserving surgery in women with larger or ptotic breasts.
abstract: BACKGROUND
  The equivalence of breast-conserving surgery followed by postoperative radiotherapy against mastectomy is now firmly established in patients with early breast cancer. The results of surgery in large-breasted women can be poor, with radiation-induced fibrosis, chronic pain and poor cosmesis contributing to long-term psychological and physical morbidity. Therapeutic mammoplasty offers an alternative management strategy to both enhance the role of breast-conserving surgery and provide better outcomes.
  
  
  METHODS
  A retrospective note review was undertaken of all patients undergoing therapeutic mammoplasty for breast malignancy between 2007 and 2011. All cases were performed using a Wise pattern-reduction technique. Histology and pathological outcomes were assessed. Postoperative outcomes reviewed included wound infection, seroma and need for further intervention.
  
  
  RESULTS
  During the study period, 20 patients underwent therapeutic mammoplasty with a mean follow-up duration of 36 months. The mean weight of the lumpectomy specimen was 330g. The average cancer size was 34mm, with a mean margin clearance of 7mm. There was one episode of wound infection and three of delayed wound healing at the T-junction. One patient required a mastectomy for involved margins. There were no recurrences at the most recent follow-up visit.
  
  
  CONCLUSIONS
  Therapeutic mammoplasty offers a tailored approach to women with larger breasts and early breast cancers with good cosmetic results and oncological outcomes.
authors.affiliation: Department of Breast Surgery, Kingston Hospital, Galsworthy Road, Kingston upon Thames, Surrey KT2 7QB, UK. a.currie@imperial.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Currie
authors.forename: K
authors.initials: K
authors.lastname: Chong
authors.forename: G L
authors.initials: GL
authors.lastname: Davies
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D016896:Treatment Outcome; D047368:Tumor Burden