title: Lipid accumulation product and insulin resistance in Iranian PCOS prevalence study.
abstract: OBJECTIVE
  To evaluate diagnostic accuracy of lipid accumulation product (LAP) index as a marker of insulin resistance in a community-based population with polycystic ovary syndrome (PCOS), compared with healthy women.
  
  
  METHODS
  Anthropometric measurements, biochemical parameters, LAP index and insulin resistance (IR) were compared in 134 PCOS subjects and 414 healthy women recruited from 1126 reproductive aged women (18-45 years), participants of the Iranian PCOS Prevalence Study. LAP was defined as [WC (cm)-58] ×TG (mmol/l)]. PCOS was diagnosed using the Rotterdam criteria, and IR was defined using the homeostatic model assessment IR. LAP, body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were compared using the two-tailed Spearman rank correlation test and analysing the receiver operating characteristic (ROC) curves for IR.
  
  
  RESULTS
  Among the PCOS subjects, the mean ± SD age, BMI, WC and WHR were 32·2 ± 7·7 years, 26·8 ± 5·8 kg/m(2) , 85·2 ± 13·2 cm and 0·80 ± 0·06, respectively, and the median (IQ25-75) of LAP index was 34·03 (17·8-66·3). There was significant correlation between HOMA-IR index and LAP in patients with PCOS (r = 0·41; P < 0·001). Also, ROC curves analysis revealed that the optimal cut-off value for LAP to define the presence of IR was 34·1 (sensitivity: 75%; specificity: 58%). LAP showed the highest area under curve (AUC) (P < 0·001).
  
  
  CONCLUSIONS
  Among PCOS subjects, LAP index has the strongest diagnostic accuracy for detection of IR in comparison with BMI, WC and WHR.
authors.affiliation: Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Hosseinpanah
authors.forename: Maryam
authors.initials: M
authors.lastname: Barzin
authors.forename: Hadi
authors.initials: H
authors.lastname: Erfani
authors.forename: Sara
authors.initials: S
authors.lastname: Serahati
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Ramezani Tehrani
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007492:Iran; D064237:Lipid Accumulation Product / Q000502:physiology*; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D055815:Young Adult