title: Lipid deposition in various sites of the skeletal muscles and liver exhibits a positive correlation with visceral fat accumulation in middle-aged Japanese men with metabolic syndrome.
abstract: Objective In addition to excess visceral fat, lipid deposition in the liver and skeletal muscle has been implicated in the pathophysiology of type 2 diabetes and metabolic syndrome. This study was designed to explore the relationship between hepatic and muscular lipid deposition and visceral fat accumulation in 105 middle-aged men with metabolic syndrome. Methods Abdominal computed tomography (CT) was used to simultaneously evaluate the visceral fat area (VFA) and CT Hounsfield unit (HU) values of three different portions of skeletal muscle and the liver. Results A significant inverse correlation was observed between the VFA and the CT HU values of the iliopsoas muscle, back muscle, rectus abdominis muscle and liver. Three types of interventions, i.e., lifestyle modification and treatment with antidiabetic drugs, such as Pioglitazone or Miglitol, caused significant decreases in visceral fat accumulation. The extent of lipid deposition in the liver was strongly correlated with the levels of glucose-lipid metabolic markers, which decreased significantly following Pioglitazone treatment. On the other hand, the amount of lipid deposition in the three skeletal muscles and the liver did not decrease after Miglitol treatment. Conclusion Visceral fat accumulation is accompanied by excess lipid deposition in skeletal muscle and the liver in patients with metabolic syndrome. The CT-based simultaneous, concise evaluations of ectopic lipid deposition and visceral fat mass used in the present study may provide unique information for assessing cardiometabolic risks and the therapeutic impact in patients with diabetes-obesity syndrome.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Medicine), Graduate School of Medicine, University of the Ryukyus, Japan.
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Taira
authors.forename: Michio
authors.initials: M
authors.lastname: Shimabukuro
authors.forename: Moritake
authors.initials: M
authors.lastname: Higa
authors.forename: Kouichi
authors.initials: K
authors.lastname: Yabiku
authors.forename: Chisayo
authors.initials: C
authors.lastname: Kozuka
authors.forename: Rei
authors.initials: R
authors.lastname: Ueda
authors.forename: Sumito
authors.initials: S
authors.lastname: Sunagawa
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Ohshiro
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Doi
authors.forename: Toyotaka
authors.initials: T
authors.lastname: Nanba
authors.forename: Eriko
authors.initials: E
authors.lastname: Kawamoto
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Takako
authors.initials: T
authors.lastname: Iha
authors.forename: Sawako
authors.initials: S
authors.lastname: Nakachi
authors.forename: Takeaki
authors.initials: T
authors.lastname: Tomoyose
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ikema
authors.forename: Ken
authors.initials: K
authors.lastname: Yamakawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Masuzaki
mesh_terms: D000328:Adult; D000368:Aged; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D040242:Risk Reduction Behavior; D014057:Tomography, X-Ray Computed
chemical_list: D007004:Hypoglycemic Agents