title: [Dissolution determination of Shuanghuanglian capsules by HPLC analysis assisted with principal component analysis].
abstract: OBJECTIVE
  To develop a quality analysis method based on self-reference principal for dissolution determination of Shuanghuanglian capsules.
  
  
  METHODS
  Dissolution of Shuanghuanglian capsules was determined by principal component analysis consociated HPLC method.
  
  
  RESULTS
  The liner of regression equation was good. The average recovery rates of quality assurance samples (QA) and quality control samples (QC) were all no less than 96. 0%. Dissolution curves of Shuanghuanlian capsules of different manufacturers and different batches of the same manufacturer had obvious disparity.
  
  
  CONCLUSIONS
  The method can better evaluate the dissolution conditions of Shuanghuanglian capsules. The prospect of the method is expected for assessing the dissolution of other oral solid dosage of traditional Chinese medicines.
authors.affiliation: College of Pharmacy, Hebei University, Baoding 071002, China.
authors.forename: Wei-Quan
authors.initials: WQ
authors.lastname: Zhang
authors.forename: Huai-Zhong
authors.initials: HZ
authors.lastname: Guo
authors.forename: Xiao-Qian
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Qian-Yi
authors.initials: QY
authors.lastname: Liu
mesh_terms: D002214:Capsules / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D025341:Principal Component Analysis / Q000379:methods*
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; C516400:shuang-huang-lian