title: Modular columnar supramolecular polymers as scaffolds for biomedical applications.
abstract: Self-assembly of discotic molecules into supramolecular polymers offers a flexible approach for the generation of multicomponent one-dimensional columnar architectures with tuneable biomedical properties. Decoration with ligands induces specific binding of the self-assembled scaffold to biological targets. The modular design allows the easy co-assembly of different discotics for the generation of probes for targeted imaging and cellular targeting with adjustable ligand density and composition.
authors.affiliation: Laboratory of Chemical Biology and Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.
authors.forename: Katja
authors.initials: K
authors.lastname: Petkau-Milroy
authors.forename: Michael H
authors.initials: MH
authors.lastname: Sonntag
authors.forename: Luc
authors.initials: L
authors.lastname: Brunsveld
mesh_terms: D001549:Benzamides / Q000737:chemistry / Q000378:metabolism; D056831:Coordination Complexes / Q000737:chemistry; D004295:Dihydroxyphenylalanine / Q000737:chemistry / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry; D008856:Microscopy, Fluorescence; D004369:Pentetic Acid / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*
chemical_list: D001549:Benzamides; D056831:Coordination Complexes; D008081:Liposomes; D011108:Polymers; C558700:benzene-1,3,5-tricarboxamide; D004295:Dihydroxyphenylalanine; D004369:Pentetic Acid
keywords: discotics; molecular imaging; self-assembly; supramolecular chemical biology; supramolecular chemistry