title: Differential caveolin-1 expression in colon carcinoma and its relation to E-cadherin-β-catenin complex.
abstract: BACKGROUND
  Colorectal cancer is the third common cancer and the second leading cause of cancer-related death in the Western world. Caveolin-1 is a new emerging prognostic marker and has different expression abilities in different cancers. The expression of caveolin-1 in colon carcinogenesis is still confusing. E-cadherin and β-catenin have a definite role in invasion and progression. Our study is designed to explore the role of caveolin-1 in cancer colon carcinogenesis and tries to elucidate the relation between its expression and E-cadherin and β-catenin expression in colon cancer.
  
  
  METHODS
  A total of 70 formalin-fixed, paraffin-embedded colon carcinoma specimens were studied for the expression of the 3 proteins, and a correlative study was done between each protein and different clinicopathologic parameters and between the 3 markers.
  
  
  RESULTS
  As the tumor becomes more aggressive and invasive and as it metastasizes, it losses the stromal caveolin-1 and E-cadherin and gains the cellular caveolin-1 and the abnormal β-catenin expression. Also, there were parallel changes between stromal caveolin-1 and E-cadherin on one side and between the cellular caveolin-1 and β-catenin on another side.
  
  
  CONCLUSIONS
  Our findings link caveolin-1 to the power of infiltration and spread, aggressiveness, and differentiation of cancer colon, and this may be happen through E-cadherin-β-catenin complex.
authors.affiliation: Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt. Electronic address: Hanan_alshenawy@yahoo.com.
authors.forename: Hanan Alsaeid
authors.initials: HA
authors.lastname: Alshenawy
authors.forename: Mona Abd El-Haq Abd El-Azeem
authors.initials: MA
authors.lastname: Ali
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D063646:Carcinogenesis; D051242:Caveolin 1 / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003106:Colon / Q000378:metabolism / Q000473:pathology; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D051242:Caveolin 1; D051176:beta Catenin
keywords: Cancer colon; Caveolin-1; E-cadherin; β-Catenin