title: [Changes of erythrocyte rheology in rabbits with acute renal failure].
abstract: OBJECTIVE
  To observe the change of erythrocyte theology in rabbits with acute renal failure (ARF).
  
  
  METHODS
  Thirty-eight healthy rabbits were randomly divided into control group (n = 8), model group (establishing ARF model via intramuscular injection 1% HgCl2, and divided into 12 h, 24 h, 48 h subgroups, all n = 10), the arterial blood sample was taken out through carotid artery at corresponding times after anesthetization with urethane, for detecting the indices of renal function and erythrocyte rheology.
  
  
  RESULTS
  The levels of urea and creatinine in plasma of model rabbits at 12 h, 24 h and 48 h were higher than those of control group, and there was a rise trend along with the time extension. The erythrocytes electrophoresis time at 12 h of model group was higher, the electrophoresis rate and migration rate of erythrocytes were lower compared with those of control group; the erythrocytes electrophoresis time at 24 h of model group was lower and the electrophoresis rate and migration rate were higher compared with those of model group at 12 h; and there were no statistical differences in erythrocytes electrophoresis indices between model group at 48 h and other groups. Meanwhile, there was a rise trend in erythrocyte sedimentation rate (ESR), K value of equation and emendation along with the time extension of ARF, but these indices only at 48 h of model group was lower significantly than that of control group. There were no statistical differences in aggregation index and deformability index of erythrocytes among groups.
  
  
  CONCLUSIONS
  During the process of ARF, the erythrocytes electrophoresis time lengthen and electrophoresis rate and migration rate decrease at early stage, and these indices gradually return to normal; the indices of ESR increase gradually.
authors.affiliation: Institute of Microcirculation, Hebei North University, Zhangjiakou 075029, China.
authors.forename: Guo-Jie
authors.initials: GJ
authors.lastname: Xu
authors.forename: Jing-Pei
authors.initials: JP
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ji
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Wu
authors.forename: Zeng-Juan
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Bao-Liang
authors.initials: BL
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Niu
authors.forename: Zi-Gang
authors.initials: ZG
authors.lastname: Zhao
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000503:physiopathology*; D000818:Animals; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000502:physiology*; D018056:Hemorheology; D011817:Rabbits