title: Short route to platencin.
abstract: The synthesis of the complex tricyclic core of the terpenoid antibiotic platencin is achieved in a concise, protecting group-free and stereoselective manner. A flexible approach that highlights the intramolecular aldol reaction as the key step toward the construction of the bicyclo[2,2,2]octane ring from an angular allyl decalone in both the trans-fused and the cis-fused forms is demonstrated.
authors.affiliation: Division of Natural Product Chemistry and Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 007, India. yadavpub@iict.res.in
authors.forename: J S
authors.initials: JS
authors.lastname: Yadav
authors.forename: Rajendar
authors.initials: R
authors.lastname: Goreti
authors.forename: Srihari
authors.initials: S
authors.lastname: Pabbaraja
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
mesh_terms: D000627:Aminophenols / Q000138:chemical synthesis* / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000627:Aminophenols; D000900:Anti-Bacterial Agents; D001643:Bridged Bicyclo Compounds; D011083:Polycyclic Compounds; D013729:Terpenes; C520340:platencin