title: Nutrient and chemical sensing by intestinal pathogens.
abstract: Pathogenic gut bacteria, such as those comprising the Enterobacteriaceae family, have evolved sophisticated virulence mechanisms, including nutrient and chemical sensing, to escape host defense strategies and produce disease. In this review we describe the mechanisms utilized by the enteric pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 to achieve successful colonization of its mammalian host.
authors.affiliation: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA.
authors.forename: Juan D
authors.initials: JD
authors.lastname: Hernandez-Doria
authors.forename: Vanessa
authors.initials: V
authors.lastname: Sperandio
mesh_terms: D001422:Bacterial Adhesion; D004927:Escherichia coli Infections / Q000276:immunology* / Q000382:microbiology*; D019453:Escherichia coli O157 / Q000378:metabolism / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D009930:Organic Chemicals / Q000378:metabolism*; D015398:Signal Transduction; D037521:Virulence Factors / Q000096:biosynthesis*
chemical_list: D009930:Organic Chemicals; D037521:Virulence Factors
keywords: Enterobacteriaceae; Signals; Two-component system; Type-III secretion