title: Managing lymphoma with non-FDG radiotracers: current clinical and preclinical applications.
abstract: Nuclear medicine imaging modalities such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) have played a prominent role in lymphoma management. PET with [(18)F]Fluoro-2-deoxy-D-glucose (FDG) is the most commonly used tool for lymphoma imaging. However, FDG-PET has several limitations that give the false positive or false negative diagnosis of lymphoma. Therefore, development of new radiotracers with higher sensitivity, specificity, and different uptake mechanism is in great demand in the management of lymphoma. This paper reviews non-FDG radiopharmaceuticals that have been applied for PET and SPECT imaging in patients with different types of lymphoma, with attention to diagnosis, staging, therapy response assessment, and surveillance for disease relapse. In addition, we introduce three radiolabeled anti-CD20 antibodies for radioimmunotherapy, which is another important arm for lymphoma treatment and management. Finally, the relatively promising radiotracers that are currently under preclinical development are also discussed in this paper.
authors.affiliation: Department of Experimental Diagnostic Imaging, Box 59, The University of TX MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. kongfanlin2007@gmail.com
authors.forename: Fan-Lin
authors.initials: FL
authors.lastname: Kong
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Ford
authors.forename: David J
authors.initials: DJ
authors.lastname: Yang
mesh_terms: D000888:Antibodies, Anti-Idiotypic; D018951:Antigens, CD20; D003952:Diagnostic Imaging; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology; D009683:Nuclear Medicine; D049268:Positron-Emission Tomography / Q000379:methods*; D011859:Radiography; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D018951:Antigens, CD20; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18