title: Acaricidal potentials of active properties isolated from Cynanchum paniculatum and acaricidal changes by introducing functional radicals.
abstract: This study evaluated the acaricidal activities of acetophenone and its derivatives for their potentials as natural acaricides using an impregnated fumigant bioassay against Dermatophagoides spp. and Tyrophagus putrescentiae . On the basis of the LD50 values against D. farinae, 3'-methoxyacetophenone (0.41 μg/cm(2)) was 89.9 times more toxic than DEET (36.87 μg/cm(2)), followed by 4'-methoxyacetophenone (0.52 μg/cm(2)), 2'-methoxyacetophenone (0.75 μg/cm(2)), 2'-hydroxy-5'-methoxyacetophenone (1.03 μg/cm(2)), 2'-hydroxy-4'-methoxyacetophenone (1.29 μg/cm(2)), acetophenone (1.48 μg/cm(2)), 2'-hydroxyacetophenone (1.74 μg/cm(2)), 2',5'-dimethoxyacetophenone (1.87 μg/cm(2)), 2',4'-dimethoxyacetophenone (2.10 μg/cm(2)), and benzyl benzoate (9.92 μg/cm(2)). In regard to structure-activity relationships between acaricidal activity and functional radicals (hydroxyl and methoxy groups) on the acetophenone skeleton, a monomethoxy group (2'-, 3'-, and 4'-methoxyacetone) on the acetophenone skeleton was more toxic than were the other groups (2',4'- and 2',5'-dimethoxyacetophenone, 2'- and 4'-hydroxyacetophenone, 2'-hydroxy-4'-methoxyacetophenone, 2'-hydroxy-5'-methoxyacetophenone, and 4'-hydroxy-3'-methoxyacetophenone). These results indicated that acaricidal activity against three mite species changed with the introduction of functional radicals (hydroxyl and methoxy groups) onto the acetophenone skeleton.
authors.affiliation: Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Sciences, Chonbuk National University , Jeonju 561-756, Republic of Korea.
authors.forename: Min-Gi
authors.initials: MG
authors.lastname: Kim
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Yang
authors.forename: Hoi-Seon
authors.initials: HS
authors.lastname: Lee
mesh_terms: D056810:Acaricides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D040041:Acaridae / Q000187:drug effects*; D000098:Acetophenones / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D031105:Cynanchum / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D007928:Lethal Dose 50; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D013329:Structure-Activity Relationship
chemical_list: D056810:Acaricides; D000098:Acetophenones; D005609:Free Radicals; D010936:Plant Extracts