title: Interrelationship of dendritic cells, type 1 interferon system, regulatory T cells and toll-like receptors and their role in lichen planus and lupus erythematosus -- a literature review.
abstract: There is evidence that the activation of some receptors of the toll-like family (TLRs) of the innate immune system, and also changes in expression levels of forkhead box p3 (Foxp3) protein, which is found in regulatory T cells (Tregs), could be involved in the development of autoimmunity. We present here a literature review focusing on the interrelationship of dendritic cells, TLRs, Tregs and type 1 interferon in autoimmune diseases, with special interest in lichen planus and lupus erythematosus. Understanding the specific role of each of these factors would help elucidate the obscure aetiology of such diseases and open new perspectives for their management and treatment.
authors.affiliation: Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Brazil.
authors.forename: Victoria Martina
authors.initials: VM
authors.lastname: Trucci
authors.forename: Fernanda Gonçalves
authors.initials: FG
authors.lastname: Salum
authors.forename: Maria Antonia
authors.initials: MA
authors.lastname: Figueiredo
authors.forename: Karen
authors.initials: K
authors.lastname: Cherubini
mesh_terms: D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000276:immunology*; D017676:Lichen Planus, Oral / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D007370:Interferon Type I; D051193:Toll-Like Receptors
keywords: Autoimmune diseases; Foxp3; Lichen planus; Lupus erythematosus; TLRs