title: Cross-sectional surveys of measles antibodies in the Jiangsu Province of China from 2008 to 2010: the effect of high coverage with two doses of measles vaccine among children.
abstract: BACKGROUND
  Changes in the epidemiological characteristics of measles since 2007 appeared in the Jiangsu province. Although the reported coverage with two doses of measles vaccine was greater than 95% in most regions of the province, measles incidence remained high across the whole province. Cross-sectional serological surveys of measles antibodies in the Jiangsu province of China were conducted from 2008 to 2010 to assess and track population immunity.
  
  
  METHODS
  Measles-specific IgG levels were measured in serum samples using ELISA. GMTs and seroprevalence with 95% CIs were calculated by region, gender, and age. ANOVA and χ(2) tests were used to test for statistically significant differences between groups for GMT levels and seroprevalence, respectively.
  
  
  RESULTS
  Seroprevalence showed a significantly increasing trend annually (CMH χ(2) = 40.32, p<0.0001). Although the seroprevalence among children aged 2-15 years was consistently over 95%, vaccine-induced measles antibodies may wane over time. Measles seropositivity in the Jiangsu province was 91.7% (95% CI: 90.1-93.2%) in 2010. Among adults aged 15 to 29-year-olds, the seropositivity rate was 88.4% (95% CI: 82.7-92.8%).
  
  
  CONCLUSIONS
  Vaccination strategies may need to be adjusted depending on the individual age and regions, particularly individuals between the ages of 8 months-14 years old and 20-29 years old. Additional SIAs are likely required to eliminate measles in China.
authors.affiliation: Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu Province, China.
authors.forename: Yuanbao
authors.initials: Y
authors.lastname: Liu
authors.forename: Peishan
authors.initials: P
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Wang
authors.forename: Xiuying
authors.initials: X
authors.lastname: Deng
authors.forename: Fubao
authors.initials: F
authors.lastname: Ma
authors.forename: Hong
authors.initials: H
authors.lastname: Tao
authors.forename: Chengmei
authors.initials: C
authors.lastname: Jia
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ding
authors.forename: Haitao
authors.initials: H
authors.lastname: Yang
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Min
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003625:Data Collection; D005260:Female; D005843:Geography; D006801:Humans; D007223:Infant; D008297:Male; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology* / Q000502:physiology; D008875:Middle Aged; D017678:Sex Distribution; D019562:Viral Load; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine