title: Application of MOBILE (mapping of oxygen by imaging lipids relaxation enhancement) to study variations in tumor oxygenation.
abstract: The aim of the study was to sensitively monitor changes in tumor oxygen using the MOBILE (mapping of oxygen by imaging lipids relaxation enhancement) technique. This method was applied in mammary tumor mouse models on an 11.7T Bruker MRI system. MOBILE was compared with functional imaging R2*, R1 of water and with pO2 measurements (using EPR oximetry and O2-dependent fluorescence quenching measurements). MOBILE was shown to be capable to monitor changes in oxygenation in tumor tissues.
authors.affiliation: Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Av.Mounier 73.40, Brussels, 1200, Belgium.
authors.forename: Bénédicte F
authors.initials: BF
authors.lastname: Jordan
authors.affiliation: Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Av.Mounier 73.40, Brussels, 1200, Belgium.
authors.forename: Julie
authors.initials: J
authors.lastname: Magat
authors.affiliation: Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Av.Mounier 73.40, Brussels, 1200, Belgium.
authors.forename: Florence
authors.initials: F
authors.lastname: Colliez
authors.affiliation: Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Av.Mounier 73.40, Brussels, 1200, Belgium.
authors.forename: Elif
authors.initials: E
authors.lastname: Ozel
authors.affiliation: Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Av.Mounier 73.40, Brussels, 1200, Belgium.
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Fruytier
authors.affiliation: Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Av.Mounier 73.40, Brussels, 1200, Belgium.
authors.forename: Valérie
authors.initials: V
authors.lastname: Marchand
authors.affiliation: Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Av.Mounier 73.40, Brussels, 1200, Belgium.
authors.forename: Lionel
authors.initials: L
authors.lastname: Mignion
authors.affiliation: Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Av.Mounier 73.40, Brussels, 1200, Belgium. Bernard.gallez@uclouvain.be.
authors.forename: Bernard
authors.initials: B
authors.lastname: Gallez
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D064593:Heterografts; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D050356:Lipid Metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D008819:Mice, Nude; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen