title: Novel strategy for synthesis of substituted benzimidazo[1,2-a]quinolines.
abstract: An efficient method for the synthesis of benzimidazo[1,2-a]quinolines under transition-metal-free conditions has been developed through a cascade reaction involving sequential aromatic nucleophilic substitution and intramolecular Knoevenagel condensation reactions. This method is applicable for the synthesis of a wide range of benzimidazo[1,2-a]quinoline derivatives from readily available 2-fluoroarylaldehyde and benzimidazole substrates.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Jun-ya
authors.initials: JY
authors.lastname: Kato
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Ito
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Ijuin
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aoyama
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yokomatsu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001562:Benzimidazoles; D011804:Quinolines; D028561:Transition Elements