title: Stabilization of a closed kinase conformation induces RAF dimerization.
abstract: BRAF inhibitors stabilize a closed, rigid RAF kinase conformation that facilitates dimerization.
mesh_terms: D015374:Biosensing Techniques; D045744:Cell Line, Tumor; D019281:Dimerization; D006801:Humans; D009154:Mutation; D011487:Protein Conformation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics*; D048490:raf Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: D047428:Protein Kinase Inhibitors; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D048490:raf Kinases