title: The application of hyaluronic acid-derivatized carbon nanotubes in hematoporphyrin monomethyl ether-based photodynamic therapy for in vivo and in vitro cancer treatment.
abstract: Carbon nanotubes (CNTs) have shown great potential in both photothermal therapy and drug delivery. In this study, a CNT derivative, hyaluronic acid-derivatized CNTs (HA-CNTs) with high aqueous solubility, neutral pH, and tumor-targeting activity, were synthesized and characterized, and then a new photodynamic therapy agent, hematoporphyrin monomethyl ether (HMME), was adsorbed onto the functionalized CNTs to develop HMME-HA-CNTs. Tumor growth inhibition was investigated both in vivo and in vitro by a combination of photothermal therapy and photodynamic therapy using HMME-HA-CNTs. The ability of HMME-HA-CNT nanoparticles to combine local specific photodynamic therapy with external near-infrared photothermal therapy significantly improved the therapeutic efficacy of cancer treatment. Compared with photodynamic therapy or photothermal therapy alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy without obvious toxic effects to normal organs. Overall, it was demonstrated that HMME-HA-CNTs could be successfully applied to photodynamic therapy and photothermal therapy simultaneously in future tumor therapy.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Shi
authors.forename: Rourou
authors.initials: R
authors.lastname: Ma
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Ruiyuan
authors.initials: R
authors.lastname: Liu
authors.forename: Lulu
authors.initials: L
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Hou
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Yu
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics / Q000528:radiation effects / Q000633:toxicity; D006415:Hematoporphyrins / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D006358:Hot Temperature; D006820:Hyaluronic Acid / Q000737:chemistry*; D007259:Infrared Rays; D051379:Mice; D008856:Microscopy, Fluorescence; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000528:radiation effects / Q000633:toxicity; D010778:Photochemotherapy / Q000379:methods*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D006415:Hematoporphyrins; D037742:Nanotubes, Carbon; C494379:hematoporphyrin monomethyl ether; D006820:Hyaluronic Acid
keywords: HA-derivatized carbon nanotubes; hematoporphyrin monomethyl ether; photodynamic therapy; photothermal therapy; synergistic effect; tumor targeting