title: The role of the inherited disorders of hemoglobin, the first "molecular diseases," in the future of human genetics.
abstract: Although the inherited hemoglobin disorders were the first genetic diseases to be explored at the molecular level, they still have important messages for the future of medical genetics. In particular, they can offer a better understanding of the evolutionary and population biology of genetic disease, the mechanisms that underlie the phenotypic diversity of monogenic disease, and how, by developing appropriate partnerships, richer countries can help low-income countries to evolve programs for the control and management of these diseases where, in many cases, they are particularly common.
authors.affiliation: Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom; email: liz.rose@imm.ox.ac.uk.
authors.forename: David J
authors.initials: DJ
authors.lastname: Weatherall
mesh_terms: D005826:Genetics, Medical / Q000639:trends; D005828:Genetics, Population; D006453:Hemoglobinopathies / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D006454:Hemoglobins / Q000235:genetics / Q000378:metabolism; D006801:Humans
chemical_list: D006454:Hemoglobins