title: AIDS treatment and mental health: evidence from Uganda.
abstract: Increased access to antiretroviral therapy (ART) in developing countries over the last decade is believed to have contributed to reductions in HIV transmission and improvements in life expectancy. While numerous studies document the effects of ART on physical health and functioning, comparatively less attention has been paid to the effects of ART on mental health outcomes. In this paper we study the impact of ART on depression in a cohort of patients in Uganda entering HIV care. We find that 12 months after beginning ART, the prevalence of major and minor depression in the treatment group had fallen by approximately 15 and 27 percentage points respectively relative to a comparison group of patients in HIV care but not receiving ART. We also find some evidence that ART helps to close the well-known gender gap in depression between men and women.
authors.affiliation: RAND Corporation, Santa Monica, CA, USA. eokeke@rand.org
authors.forename: Edward N
authors.initials: EN
authors.lastname: Okeke
authors.forename: Glenn J
authors.initials: GJ
authors.lastname: Wagner
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000453:epidemiology*; D003865:Major Depressive Disorder / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology*; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D017678:Sex Distribution; D016896:Treatment Outcome; D014454:Uganda / Q000453:epidemiology
chemical_list: D044966:Anti-Retroviral Agents
keywords: Africa; Antiretroviral therapy; HIV; Mental health