title: Antimalarial drug targets and drugs targeting dolichol metabolic pathway of Plasmodium falciparum.
abstract: Because of mutation and natural selection, development of drug resistance to the existing antimalarial is the major problem in malaria treatment. This problem has created an urgent need of novel antimalarial drug targets as well as lead compounds. The important characteristic of malaria is that it shows the phenomenon of balanced polymorphisms. Several traits have been selected in response to disease pressure. Therefore such factors must be explored to understand the pathogenesis of malaria infection in human host. Apicoplast, hub of metabolism is present in Plasmodium falciparum (causative agent of falciparum malaria) having similarities with plant plastid. Among several pathways in apicoplast, Dolichol metabolic pathway is one of the most important pathway and has been known to play role in parasite survival in the human host. In P.falciparum, a phosphorylated derivative of Dolichol participates in biosynthesis of glycoproteins. Several proteins of this pathway play role in post translational modifications of proteins involved in the signal transduction pathways, regulation of DNA replication and cell cycle. This pathway can be used as antimalarial drug target. This report has explored progress towards the study of proteins and inhibitors of Dolichol metabolic pathway. For more comprehensive analysis, the host genetic factors and drug-protein interaction have been covered.
authors.forename: Tabish
authors.initials: T
authors.lastname: Qidwai
authors.forename: Avantika
authors.initials: A
authors.lastname: Priya
authors.forename: Nihal Ahmad
authors.initials: NA
authors.lastname: Khan
authors.forename: Himanshu
authors.initials: H
authors.lastname: Tripathi
authors.forename: Feroz
authors.initials: F
authors.lastname: Khan
authors.forename: Mahendra Pandurang
authors.initials: MP
authors.lastname: Darokar
authors.forename: Anirban
authors.initials: A
authors.lastname: Pal
authors.forename: Dnyneshwar U
authors.initials: DU
authors.lastname: Bawankule
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Shukla
authors.affiliation: Department of Metabolic & Structural Biology, CSIR-Central Institute of Medicinal & Aromatic Plants, P.O.-CIMAP, Kukrail Picnic Spot Road, Lucknow-226015 (U.P.), India. f.khan@cimap.res.in.
authors.forename: Rajendra Singh
authors.initials: RS
authors.lastname: Bhakuni
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D063546:Apicoplasts / Q000378:metabolism*; D002453:Cell Cycle / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D004286:Dolichols / Q000031:analogs & derivatives* / Q000235:genetics / Q000378:metabolism; D015195:Drug Design; D017125:Genes, Protozoan; D014644:Genetic Variation; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010766:Phosphorylation; D010963:Plasmodium falciparum / Q000187:drug effects / Q000378:metabolism* / Q000472:pathogenicity; D020641:Polymorphism, Single Nucleotide; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000962:Antimalarials; D004286:Dolichols; D015800:Protozoan Proteins