title: Mucinous Cystadenoma in the Upper Lip: Report of Two Cases.
abstract: Mucinous cystadenoma of the salivary gland is a very rare disease, and only a few cases have been reported. We report here 2 cases of mucinous cystadenoma in the upper lip. The first case was a 57-year-old man and the second was a 42-year-old woman. The tumors were painless nodules with a smooth-surfaced mucosa, and surgical excisions were performed. Histologically, the tumors were surrounded by a fibrous capsule and were composed of multiple cysts lined with columnar epithelial cells. The tumor cells contain mucous substances that reacted with periodic acid-Schiff base and Alcian blue. Immunohistochemical staining revealed that the tumor cells expressed cytokeratin (AE1/3 and CK7), but their immunoreactivity with MIB-1 (Ki-67) was less than 3%. They had negative immunoreactivity for neuroectoderm markers, S-100 protein, and myoepithelial markers, p63, α-smooth muscle actin, and calponin, except for the accompanying myoepithelial-like cells. No recurrences were noted after surgery at 7 years and 1 year, respectively.
authors.affiliation: Kochi Medical School, Kochi University, Nankoku-City, Kochi, Japan tyamada@kochi-u.ac.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yamada
authors.affiliation: Kochi Medical School, Kochi University, Nankoku-City, Kochi, Japan.
authors.forename: Mayu
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Kochi Medical School Hospital, Nankoku-City, Kochi, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Matsumoto
authors.affiliation: Kochi Medical School Hospital, Nankoku-City, Kochi, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Toi
authors.affiliation: Kochi Medical School, Kochi University, Nankoku-City, Kochi, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Ohno
authors.affiliation: Kochi Medical School, Kochi University, Nankoku-City, Kochi, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Kitamura
authors.affiliation: Kochi Medical School, Kochi University, Nankoku-City, Kochi, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Sasabe
authors.affiliation: Kochi Medical School, Kochi University, Nankoku-City, Kochi, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D018291:Cystadenoma, Mucinous / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008048:Lip Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: lip; minor salivary gland; mucinous cystadenoma