title: 2-[18F]fludarabine, a novel positron emission tomography (PET) tracer for imaging lymphoma: a micro-PET study in murine models.
abstract: OBJECTIVE
  Fludarabine has proven to be of considerable efficacy in the treatment of low-grade lymphomas. We have developed the labeling of this drug with fluorine-18 and evaluated 2-[(18)F]fludarabine as a novel positron emission tomography (PET) probe for in vivo imaging.
  
  
  METHODS
  Preclinical studies were conducted with 2-[(18)F]fludarabine, in parallel with 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG), in Swiss CD-1 and CB17 severely combined immunodeficient (SCID) mice, both as tumor-free control groups, and SCID mice bearing RL lymphomas.
  
  
  RESULTS
  In Swiss mice, micro-PET studies with 2-[(18)F]fludarabine showed a distribution restricted to the organs of excretion and the spleen, the latter being less evident in SCID animals. In lymphoma-bearing SCID mice, 2-[(18)F]fludarabine demonstrated a rapid tumor uptake over the first 20 min which subsequently plateaued and provided an improved contrast than that of [(18)F]FDG.
  
  
  CONCLUSIONS
  This radiotracer merits further evaluation to establish its clinical usefulness to image low-grade lymphoma in humans in future clinical investigations.
authors.affiliation: CEA, DSV/I2BM, LDM-TEP Group, GIP Cyceron, Bd Henri Becquerel, , BP 5229, , 14074, Caen Cedex, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Dhilly
authors.forename: Stéphane
authors.initials: S
authors.lastname: Guillouet
authors.forename: Delphine
authors.initials: D
authors.lastname: Patin
authors.forename: Fabien
authors.initials: F
authors.lastname: Fillesoye
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abbas
authors.forename: Fabienne
authors.initials: F
authors.lastname: Gourand
authors.forename: Olivier
authors.initials: O
authors.lastname: Tirel
authors.forename: Françoise
authors.initials: F
authors.lastname: Galateau
authors.forename: Eric T
authors.initials: ET
authors.lastname: MacKenzie
authors.forename: Charles
authors.initials: C
authors.lastname: Dumontet
authors.forename: Michel
authors.initials: M
authors.lastname: Leporrier
authors.forename: Louisa
authors.initials: L
authors.lastname: Barré
mesh_terms: D000328:Adult; D000818:Animals; D004195:Disease Models, Animal; D019788:Fluorodeoxyglucose F18 / Q000097:blood / Q000737:chemistry; D006801:Humans; D008224:Lymphoma, Follicular / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D051379:Mice; D016513:Mice, SCID; D049268:Positron-Emission Tomography; D011874:Radiometry; D014018:Tissue Distribution; D014740:Vidarabine / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry
chemical_list: D019788:Fluorodeoxyglucose F18; D014740:Vidarabine; C024352:fludarabine