title: The influence of g.19124G>a genetic polymorphism in the OPG gene on bone mineral density in Chinese women.
abstract: OBJECTIVE
  The aim of this study was to detect the influence of g.19124G>A genetic polymorphism in the osteoprotegerin (OPG) gene on bone mineral density (BMD) and osteoporosis in Chinese postmenopausal women.
  
  
  METHODS
  A total of 403 primary osteoporosis subjects and 409 healthy controls were enrolled in this study. The BMD value of the femoral neck hip, lumbar spine (L(2-4)), and total hip was analyzed by Norland XR-46 dual energy X-ray absorptiometry. The polymerase chain reaction-restriction fragment length polymorphism method was utilized to investigate the genotype of g.19124G>A genetic polymorphism.
  
  
  RESULTS
  We found significant differences of the femoral neck hip, lumbar spine (L(2-4)), and total hip of BMD among different genotypes of g.19124G>A genetic polymorphism, individuals with the genotype GG had significantly higher BMD than those of genotype GA and AA (p<0.05).
  
  
  CONCLUSIONS
  These findings indicate that the g.19124G>A genetic polymorphism in the OPG gene is potentially related to BMD and osteoporosis in Chinese postmenopausal women, and the allele A could be associated with a lower BMD and an increased risk factor for osteoporosis.
authors.affiliation: Department of Emergency, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, People's Republic of China. jiezhu_12@sina.com
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.forename: Zitong
authors.initials: Z
authors.lastname: Luo
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
authors.forename: Menglei
authors.initials: M
authors.lastname: Yu
authors.forename: Jicai
authors.initials: J
authors.lastname: Peng
authors.forename: Duping
authors.initials: D
authors.lastname: Huang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D015519:Bone Density / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D053244:Osteoprotegerin / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human