title: Concomitant lymphocyte-rich classical Hodgkin's lymphoma and Warthin's tumor.
abstract: Lymphomas associated with Warthin's tumor (WT) are extremely rare. Here, we report the simultaneous occurrence of lymphocyte-rich classical Hodgkin's lymphoma (LRCHL) and WT in a 78-year-old patient whose symptoms included an enlargement of the left parotid gland. Upon parotidectomy, the tissue specimen showed a WT with extensive replacement of the lymphoid stroma by small lymphocytes and some scattered Reed-Sternberg cells; however, the oncocytic epithelium was preserved. Further investigation revealed mediastinal and abdominal lymphadenopathy, consistent with stage IVB disease. To our knowledge, this is the first case report of LRCHL associated with WT. The lymphoid stroma in WT is part of the systemic lymphoid tissue and thus may be involved in the dissemination of the lymphoma. This case serves as a reminder that a careful evaluation of the histomorphological and immunohistological features of the lymphoid tissue is required for a WT biopsy.
authors.affiliation: Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China.
authors.forename: Ye-qing
authors.initials: YQ
authors.lastname: Liu
authors.forename: Qiong-lan
authors.initials: QL
authors.lastname: Tang
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Wang
authors.forename: Qing-yu
authors.initials: QY
authors.lastname: Liu
authors.forename: Song
authors.initials: S
authors.lastname: Fan
authors.forename: Hai-gang
authors.initials: HG
authors.lastname: Li
mesh_terms: D000235:Adenolymphoma / Q000473:pathology*; D000368:Aged; D004848:Epithelium / Q000473:pathology; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D024862:Oxyphil Cells / Q000473:pathology; D010307:Parotid Neoplasms / Q000473:pathology*; D016539:Reed-Sternberg Cells / Q000473:pathology