title: Validity of the International HIV dementia scale in Brazil.
abstract: HIV-associated neurocognitive disorders (HAND) remain prevalent in highly active antiretroviral therapy (HAART) era. Tests to detect HAND are needed for early diagnosis and treatment. Validity of International HIV Dementia Scale (IHDS) has been determined in different countries. The aims of this study were validate IHDS in a Brazilian cohort of HIV-patients and verify if IHDS can be reliably administered by a non-clinician health professional. One hundred and eighty-seven (187) patients were submitted to a full neuropsychological assessment. IHDS was administered twice to each patient (by a non-clinician and by a neurologist). HAND was diagnosed in 98 individuals (68 on HAART). IHDS had sensitivity of 55% and specificity of 80%. IHDS had fair agreement with neuropsychological tests (k 0.355) and moderate-to-strong agreement between different evaluators (interclass correlation coefficient (ICC) 0.684). HAND is prevalent nowadays. IHDS is quick and easy to administer, but has marginal sensitivity for the detection of HIV cognitive impairment other than dementia.
authors.affiliation: Clinical Research Laboratory on Neuroinfection Diseases, Evandro Chagas Clinical Research Institute (IPEC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro RJ, Brazil.
authors.forename: Roiza Almeida
authors.initials: RA
authors.lastname: Rodrigues
authors.forename: Raquel Lisboa
authors.initials: RL
authors.lastname: Oliveira
authors.forename: Beatriz
authors.initials: B
authors.lastname: Grinsztejn
authors.forename: Marcus Tulius T
authors.initials: MT
authors.lastname: Silva
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis*; D000328:Adult; D000367:Age Factors; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D001938:Brazil; D003072:Cognition Disorders / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000295:instrumentation; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D012372:ROC Curve; D015203:Reproducibility of Results; D055815:Young Adult