title: CT perfusion can predict overexpression of CXCL8 (interleukin-8) in head and neck squamous cell carcinoma.
abstract: OBJECTIVE
  Increased angiogenesis in head and neck squamous cell carcinoma correlates to more aggressive tumors with increased morbidity. Because both elevated blood flow and high serum CXCL8 levels are correlated with increased angiogenesis, our objective was to see if elevated blood flow measured with CT perfusion correlated with CXCL8 levels, thereby helping to identify candidates for targeted therapies that inhibit the Bcl-2 proangiogenic pathway associated with CXCL8.
  
  
  METHODS
  Seven patients with locally recurrent or metastatic head and neck squamous cell carcinoma were enrolled in the trial. These patients underwent CT perfusion and the following parameters were measured: blood volume, blood flow, capillary permeability, and MTT; relative values were calculated by dividing by normal-appearing muscle. Serum was drawn for CXCL8 enzyme-linked immunosorbent assay analysis in these patients.
  
  
  RESULTS
  There was a significant positive correlation between the CXCL8 levels and relative blood flow (r = 0.94; P = .01). No correlation was found between CXCL8 and relative blood volume, relative capillary permeability, or relative MTT.
  
  
  CONCLUSIONS
  Relative blood flow may be useful as a surrogate marker for elevated CXCL8 in patients with head and neck squamous cell cancer. Patients with elevated relative blood flow may benefit from treatment targeting the Bcl-2 proangiogenic pathways.
authors.affiliation: Departments of Radiology.
authors.forename: S Y
authors.initials: SY
authors.lastname: Jo
authors.forename: P I
authors.initials: PI
authors.lastname: Wang
authors.forename: J E
authors.initials: JE
authors.lastname: Nör
authors.forename: E L
authors.initials: EL
authors.lastname: Bellile
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: F P
authors.initials: FP
authors.lastname: Worden
authors.forename: A
authors.initials: A
authors.lastname: Srinivasan
authors.forename: S K
authors.initials: SK
authors.lastname: Mukherji
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000000981:diagnostic imaging*; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging*; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000097:blood* / Q000000981:diagnostic imaging; D055420:Perfusion Imaging / Q000379:methods*; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D000077195:Squamous Cell Carcinoma of Head and Neck; D014057:Tomography, X-Ray Computed / Q000379:methods*; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C508606:CXCL8 protein, human; D016209:Interleukin-8