title: Association of the rs7903146 polymorphism in transcription factor 7-like 2 (TCF7L2) gene with gestational diabetes mellitus: a meta-analysis.
abstract: A meta-analysis was performed to assess the association between the transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 (IVS3C > T) and gestational diabetes mellitus (GDM). A comprehensive search was conducted to identify all case-control or cohort design studies of the above-mentioned associations. The fixed or random effect pooled measure was selected on the basis of homogeneity test among studies. Heterogeneity among studies was evaluated using the I(2). Meta-regression was used to explore the potential sources of between-study heterogeneity. Publication bias was estimated using Egger's linear regression test. A total of 10 studies including 3404 cases and 6473 controls were involved in this meta-analysis. Overall, after excluding articles that deviated from HWE in controls, and further the key contributors to between-study heterogeneity, significant associations between TCF7L2 rs7903146 genetic polymorphism and risk of gestational diabetes mellitus were observed in the dominant (OR 1.653, 95% CI 1.416-1.930) and codominant (OR 1.525, 95% CI 1.350-1.723) models. The meta-analysis suggests that TCF7L2 rs7903146 genetic polymorphism was associated with increased risk of gestational diabetes mellitus.
authors.affiliation: Department of Public Health, Medical College of Qingdao University , Qingdao, Shandong , P.R. China.
authors.forename: Shan
authors.initials: S
authors.lastname: Kang
authors.forename: Zhutian
authors.initials: Z
authors.lastname: Xie
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000706:statistics & numerical data; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein