title: [Study on effect of Hypericum perforatum on pharmacokinetics of zedoary turmeric oil in compound antiviral preparation].
abstract: OBJECTIVE
  To study zedoary turmeric oil (ZTO) and the pharmacokinetics of its homemade compound antiviral preparation in New Zealand rabbits.
  
  
  METHODS
  RP-HPLC was used to determinate the content of germacrone in rabbit plasma after oral administration.
  
  
  RESULTS
  After oral administration of ZTO and its homemade compound antiviral preparation, the plasma concentration-time curve of germacrone is in conformity to two-compartment open model. The pharmacokinetic parameters of ZTO: t1/2alpha, t1/2beta, Vd, CL, AUC and Ka were (1.52 +/- 0.59), (1.97 +/- 0.27) h, (47.59 +/- 2.29) L x kg(-1), (176.77 +/- 7.65) L x h(-1) x kg(-1), (5.70 +/- 0.70) mg x h x L(-1) and (0.97 +/- 0.11) h(-1), respectively, while those of compound preparation were (0.41 +/- 0.03), (1.47 +/- 0.35) h, (75.21 +/- 5.21) L x kg(-1), (287.79 +/- 6.39) L x h(-1) x kg(-1), (3.91 +/- 0.53) mg x h x L(-1) and (5.14 +/- 1.26) h(-1), respectively. There was no significant difference between the above two groups of pharmacokinetic parameters, expect that Ka of compound preparation was significantly higher than that of ZTO (P < 0.05).
  
  
  CONCLUSIONS
  Hypericum perforatum in compound preparation doesn't impact the distribution and elimination of active ingredients of ZTO in New Zealand rabbits, but it improves the absorption speed, and shortens the time of drug absorption, which contributes to rapid efficacy of ZTO in rabbits.
authors.affiliation: Biopharmaceutical Institute of Jinan University, Guangzhou 510632, China. yullihi@126.com
authors.forename: Yin-Yu
authors.initials: YY
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Bei
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Jian-An
authors.initials: JA
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Zhao
authors.forename: Qiao-Xue
authors.initials: QX
authors.lastname: Xiao
authors.forename: Min-Jing
authors.initials: MJ
authors.lastname: Zhang
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Huang
authors.forename: Qi
authors.initials: Q
authors.lastname: Xiang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000493:pharmacokinetics*; D030024:Curcuma / Q000737:chemistry*; D004339:Drug Compounding; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D010938:Plant Oils / Q000493:pharmacokinetics*; D011817:Rabbits; D045788:Sesquiterpenes, Germacrane / Q000493:pharmacokinetics
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D010938:Plant Oils; D045788:Sesquiterpenes, Germacrane; C048393:germacrone