title: Osteoprotegerin: multiple partners for multiple functions.
abstract: Osteoprotegerin (OPG) is an essential secreted protein in bone turnover due to its role as a decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) in the osteoclasts, thus inhibiting their differentiation. However, there are additional ligands of OPG that confer various biological functions. OPG can promote cell survival, cell proliferation and facilitates migration by binding TNF-related apoptosis inducing ligand (TRAIL), glycosaminoglycans or proteoglycans. A large number of in vitro, pre-clinical and clinical studies provide evidences of OPG involvement in vascular, bone, immune and tumor biology. This review describes an overview of the different OPG ligands regulating its biological functions.
authors.affiliation: INSERM, UMR957, Nantes F-44035, France; Université de Nantes, Nantes atlantique universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes F-44035, France; CHU, Hôtel Dieu, Nantes, France. Electronic address: marc.baudhuin@univ-nantes.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Baud'huin
authors.forename: Laurence
authors.initials: L
authors.lastname: Duplomb
authors.forename: Stéphane
authors.initials: S
authors.lastname: Teletchea
authors.forename: François
authors.initials: F
authors.lastname: Lamoureux
authors.forename: Carmen
authors.initials: C
authors.lastname: Ruiz-Velasco
authors.forename: Mike
authors.initials: M
authors.lastname: Maillasson
authors.forename: Françoise
authors.initials: F
authors.lastname: Redini
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Heymann
authors.forename: Dominique
authors.initials: D
authors.lastname: Heymann
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism*; D053244:Osteoprotegerin / Q000235:genetics / Q000378:metabolism*; D053245:RANK Ligand / Q000235:genetics / Q000378:metabolism; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics / Q000378:metabolism
chemical_list: D053244:Osteoprotegerin; D053245:RANK Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand; C506030:TNFRSF11B protein, human; C505653:TNFSF10 protein, human; C505688:TNFSF11 protein, human
keywords: Cell adhesion; Glycosaminoglycans; Monocytes; Osteoprotegerin