title: An evaluation of nitric oxide, folate, homocysteine levels and lipid peroxidation in postmenopausal osteoporosis.
abstract: OBJECTIVE
  In the current study, the risk coefficients of nitric oxide (NO), folate, homocysteine levels and lipid peroxidation in postmenopausal osteoporotic women were determined.
  
  
  METHODS
  Bone mineral density was determined by dual-energy X-ray absorptiometry. The levels of serum lipid peroxidation products such as the thiobarbituric acid adduct of malondialdehyde (MDA) were measured spectrophotometrically. Plasma folate and homocysteine (Hcy) levels were measured by enzyme chemiluminescence immunoassay. Plasma nitrite levels were measured with the Griess reaction
  
  
  RESULTS
  The odds ratios and 95% Confidence Intervals (CI) of the variables MDA, folate, NO, body-mass index (BMI), menopause age and age were found significant. MDA, NO and folate variables were found statistically significant in the analysis of receiver operating charecteristic (ROCs). The areas under the curve (AUCs, 95% CI) of MDA, NO and folate were found to be statistically significant.
  
  
  CONCLUSIONS
  The current study indicates that NO, MDA and folate are risk variables for postmenopausal osteoporosis.
authors.affiliation: Department of Biophysics, Dicle University, Turkey. vakpolat@dicle.edu.tr
authors.forename: Veysi
authors.initials: V
authors.lastname: Akpolat
authors.forename: H Murat
authors.initials: HM
authors.lastname: Bilgin
authors.forename: M Yusuf
authors.initials: MY
authors.lastname: Celik
authors.forename: Mahmut
authors.initials: M
authors.lastname: Erdemoglu
authors.forename: Birgul
authors.initials: B
authors.lastname: Isik
mesh_terms: D000368:Aged; D019540:Area Under Curve; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D016015:Logistic Models; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D016017:Odds Ratio; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D012372:ROC Curve
chemical_list: D006710:Homocysteine; D009569:Nitric Oxide; D008315:Malondialdehyde; D005492:Folic Acid