title: Dexmedetomidine reduced cytokine release during postpartum bleeding-induced multiple organ dysfunction syndrome in rats.
abstract: Dexmedetomidine (DEX) is an α 2-adrenergic agonist. It decreases the levels of norepinephrine release, resulting in a reduction of postsynaptic adrenergic activity. In the present study, the effects of DEX on postpartum bleeding-induced multiple organ dysfunction syndrome (BMODS) were studied in rats in which BMODS was induced by the combination of hypotension and clamping of the superior mesenteric artery. We evaluated the role of dexmedetomidine (DEX) in cytokine release during postpartum BMODS in rats. In summary, the present study demonstrated that DEX administration reduced IFN-r and IL-4 release and decreased lung injury during postpartum BMODS. It is possible that DEX administration decreased inflammatory cytokine production in BMODS by inhibiting inflammation and free radical release by leukocytes independent of the DEX dose.
authors.affiliation: Department of Anesthesiology, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Xianbao
authors.forename: Zhan
authors.initials: Z
authors.lastname: Hong
authors.forename: Zeng
authors.initials: Z
authors.lastname: Xu
authors.forename: Zhang
authors.initials: Z
authors.lastname: Chunfang
authors.forename: Chen
authors.initials: C
authors.lastname: Dunjin
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D020927:Dexmedetomidine / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000150:complications*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D055370:Lung Injury / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D009102:Multiple Organ Failure / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D049590:Postpartum Period; D011247:Pregnancy; D051381:Rats
chemical_list: D016207:Cytokines; D020927:Dexmedetomidine