title: Fasting versus post-challenge triglycerides and pre-existing cavitating lacunes: a berlin "cream & sugar" substudy.
abstract: OBJECTIVE
  Although the presence of cavitating lacunes on brain imaging may have prognostic implications, the modifiable risk factors underlying these frequently observed lesions are not completely understood. We sought to determine if fasting and post-challenge triglycerides associate with cavitating lacunes.
  
  
  METHODS
  All first ischemic stroke patients who completed a novel combined oral triglyceride and glucose tolerance test and MRI between January 2009 and June 2012 were included. Fluid-attenuated inversion recovery or T2 MRI sequences were used to visualize cavitating lacunes and white matter hyperintensities, which were graded using the Wahlund visual scale.
  
  
  RESULTS
  One hundred and ninety patients were included (median age 66, IQR 52-73; 33% female; median National Institute of Health Stroke Scale 2, IQR 1-4). A forward stepwise binary logistical regression analysis applying the Hosmer-Lemeshow goodness of fit test adjusted for parameters significant in univariate analyses (at the p < 0.10 level) revealed that Wahlund scores (Wahlund 0-4: reference; Wahlund 5-10: adjusted odds ratio, 5.1; 95% confidence interval, 1.3-20.0, p = 0.019; Wahlund>10: adjusted odds ratio 9.6; 95% CI, 1.55-59.35; p = 0.015) and the highest quartile of post-challenge triglycerides (>295 mg/dL; adjusted odds ratio, 7.36; 95% confidence interval 1.24-43.70; p = 0.028) independently associated with the presence of cavitating lacunes.
  
  
  CONCLUSIONS
  Post-challenge serum triglycerides are independently associated with the presence of cavitating lacunes.
authors.affiliation: Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin , Berlin , Germany.
authors.forename: Christopher O
authors.initials: CO
authors.lastname: Leonards
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Jochen B
authors.initials: JB
authors.lastname: Fiebach
authors.forename: Matthias
authors.initials: M
authors.lastname: Endres
authors.forename: Martin
authors.initials: M
authors.lastname: Ebinger
keywords: cerebral lacunes; glucose; ischemia; leukoaraiosis; triglycerides; white matter disease