title: Isolation and structure elucidation of the main UV-A photoproducts of vandetanib.
abstract: Exposure of aqueous solutions of the antitumor drug vandetanib to UV-A light results in the photochemical degradation. Two main photodegradation products were identified by HPLC-MS analysis and their structures were elucidated, after their isolation by HPLC, on the basis of LC-MS and NMR spectra. The photoproducts derived from a simple debromination (N-(2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4 yl)methoxy)quinazolin-4-amine, FP3) or from the loss of the bromide atom followed by the solvent addition (N-(4-hydroxy-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4 yl)methoxy)quinazolin-4-amine, FP2). At our knowledge this is the first report about the photodegradation of vandetanib.
authors.affiliation: Department of Sciences of Drug, University of Padova, Italy. stefano.dallacqua@unipd.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Dall'acqua
authors.forename: Daniela
authors.initials: D
authors.lastname: Vedaldi
authors.forename: Alessia
authors.initials: A
authors.lastname: Salvador
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000528:radiation effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D010777:Photochemistry / Q000379:methods; D010782:Photolysis; D010880:Piperidines / Q000737:chemistry* / Q000528:radiation effects*; D011799:Quinazolines / Q000737:chemistry* / Q000528:radiation effects*; D012996:Solutions / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D000970:Antineoplastic Agents; D010880:Piperidines; D011799:Quinazolines; D012996:Solutions; D012997:Solvents; C452423:vandetanib
keywords: HPLC; Photoproduct; Photostability; Phototoxicity; Vandetanib