title: Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine.
abstract: Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNA(Phe) in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arizona, 1041 E. Lowell Street, Tucson, AZ 85701, United States.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Young
authors.forename: Vahe
authors.initials: V
authors.lastname: Bandarian
mesh_terms: D055162:Biocatalysis; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D009705:Nucleosides / Q000096:biosynthesis* / Q000737:chemistry; D012343:RNA, Transfer / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D009705:Nucleosides; C467591:wybutosine; D012343:RNA, Transfer