title: Effects of Nogo-A receptor antagonist on the regulation of the Wnt signaling pathway and neural cell proliferation in newborn rats with hypoxic ischemic encephalopathy.
abstract: Hypoxic ischemic encephalopathy is a serious condition due to inadequate oxygen supply to the brain. Regeneration of neural cells is a critical process for repairing the damaged brain. Nogo has been identified as an inhibitor of neurite outgrowth that is specific to the brain. In the present study, the Nogo-A receptor (NgR) antagonist NEP1-40 was used to study the effects of inhibition of NgR on the regeneration of neural cells and the related Wnt signaling pathway in newborn rats. The investigation focused on the transcription factors regulated in the Wnt signaling pathway during the repair process, together with the proliferation of neural cells. The results indicated that c-Jun and c-Myc were the main transcription factors involved in the Wnt signaling pathway, while neural cell proliferation in the subventricular zone was increased during this process.
authors.affiliation: Department of Orthopedic Surgery, Clinical Medical College of Yangzhou, University of Yangzhou, Yangzhou, Jiangsu 225001, P.R. China.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Jiaxiang
authors.initials: J
authors.lastname: Gu
authors.forename: Xinmin
authors.initials: X
authors.lastname: Feng
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Tao
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D049109:Cell Proliferation / Q000187:drug effects; D015237:Dinoprost / Q000031:analogs & derivatives / Q000032:analysis; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D009185:Myelin Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D009416:Nerve Regeneration / Q000187:drug effects; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D000070798:Nogo Proteins; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation / Q000187:drug effects; D060449:Wnt Signaling Pathway / Q000187:drug effects*
chemical_list: D019394:Ki-67 Antigen; D009185:Myelin Proteins; C457761:NEPI-40 protein, rat; D000070798:Nogo Proteins; D010446:Peptide Fragments; D016271:Proto-Oncogene Proteins c-myc; C000603197:Rtn4 protein, rat; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D048031:JNK Mitogen-Activated Protein Kinases