title: Synthesis and cytotoxicity of chalcones and 5-deoxyflavonoids.
abstract: Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. Among them, 13 and 17~22 are new compounds. The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds 2, 4, 5, 6, 10, 15, and 19 exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol).
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xin-Ling
authors.initials: XL
authors.lastname: Fu
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.forename: Qiu-An
authors.initials: QA
authors.lastname: Wang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D047188:Chalcones / Q000032:analysis / Q000138:chemical synthesis* / Q000633:toxicity*; D005419:Flavonoids / Q000138:chemical synthesis* / Q000633:toxicity*; D006801:Humans; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D047188:Chalcones; D005419:Flavonoids