title: A new cytotoxic carbazole alkaloid and two new other alkaloids from Clausena excavata.
abstract: One new carbazole alkaloid, excavatine A (1), and two additional new alkaloids, excavatine B (2) and excavatine C (3), were isolated from the stems and leaves of Clausena excavata Burm.f. (Rutaceae). Their structures were determined on the basis of detailed spectroscopic analyses, especially 2D-NMR and HR-EI-MS data. Compounds 1-3 were tested for their cytotoxic activities against A549, HeLa, and BGC-823 cancer cell lines, and for their antimicrobial activities against Candida albicans and Staphylococcus aureus. Only 1 exhibited cytotoxicity against A549 and HeLa cell lines with the IC50 values of 5.25 and 1.91 μg/ml, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P R China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Peng
authors.forename: Guang-Zhi
authors.initials: GZ
authors.lastname: Zeng
authors.forename: Wei-Wu
authors.initials: WW
authors.lastname: Song
authors.forename: Ning-Hua
authors.initials: NH
authors.lastname: Tan
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D002176:Candida albicans / Q000187:drug effects; D002227:Carbazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D054700:Clausena / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D002227:Carbazoles; C586263:excavatine A; C041514:carbazole
keywords: Alkaloids; Carbazole alkaloids; Clausena excavata; Cytotoxic activity; Excavatines A - C