title: Decoys and Regulatory "Receptors" of the IL-1/Toll-Like Receptor Superfamily.
abstract: Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL-18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.
authors.affiliation: Department of Inflammation and Immunology, Humanitas Clinical and Research Center , Rozzano , Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Garlanda
authors.forename: Federica
authors.initials: F
authors.lastname: Riva
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bonavita
authors.forename: Stefania
authors.initials: S
authors.lastname: Gentile
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
keywords: cytokine; decoy receptor; inflammation; interleukin-1