title: Obesity alters the gustatory perception of lipids in the mouse: plausible involvement of lingual CD36.
abstract: A relationship between orosensory detection of dietary lipids, regulation of fat intake, and body mass index was recently suggested. However, involved mechanisms are poorly understood. Moreover, whether obesity can directly modulate preference for fatty foods remains unknown. To address this question, exploration of the oral lipid sensing system was undertaken in diet-induced obese (DIO) mice. By using a combination of biochemical, physiological, and behavioral approaches, we found that i) the attraction for lipids is decreased in obese mice, ii) this behavioral change has an orosensory origin, iii) it is reversed in calorie-restricted DIO mice, revealing an inverse correlation between fat preference and adipose tissue size, iv) obesity suppresses the lipid-mediated downregulation of the lipid-sensor CD36 in circumvallate papillae, usually found during the refeeding of lean mice, and v) the CD36-dependent signaling cascade controlling the intracellular calcium levels ([Ca(2+)]i) in taste bud cells is decreased in obese mice. Therefore, obesity alters the lipid-sensing system responsible for the oral perception of dietary lipids. This phenomenon seems to take place through a CD36-mediated mechanism, leading to changes in eating behavior.
authors.affiliation: Physiologie de la Nutrition et Toxicologie (NUTox), UMR U866 INSERM/Université de Bourgogne/AgroSup Dijon, F-21000 Dijon, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Chevrot
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bernard
authors.forename: Déborah
authors.initials: D
authors.lastname: Ancel
authors.forename: Marjorie
authors.initials: M
authors.lastname: Buttet
authors.forename: Céline
authors.initials: C
authors.lastname: Martin
authors.forename: Souleymane
authors.initials: S
authors.lastname: Abdoul-Azize
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Merlin
authors.forename: Hélène
authors.initials: H
authors.lastname: Poirier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Niot
authors.forename: Naim Akhtar
authors.initials: NA
authors.lastname: Khan
authors.forename: Patricia
authors.initials: P
authors.lastname: Passilly-Degrace
authors.forename: Philippe
authors.initials: P
authors.lastname: Besnard
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001522:Behavior, Animal; D018955:CD36 Antigens / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000494:pharmacology*; D005518:Food Preferences / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology; D055697:Taste Perception / Q000187:drug effects*; D014059:Tongue / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
chemical_list: D018955:CD36 Antigens; D004041:Dietary Fats
keywords: calcium imaging; health; long-chain fatty acids; taste sensitivity