title: Simplified method for including spatial correlations in mean-field approximations.
abstract: Biological systems involving proliferation, migration, and death are observed across all scales. For example, they govern cellular processes such as wound healing, as well as the population dynamics of groups of organisms. In this paper, we provide a simplified method for correcting mean-field approximations of volume-excluding birth-death-movement processes on a regular lattice. An initially uniform distribution of agents on the lattice may give rise to spatial heterogeneity, depending on the relative rates of proliferation, migration, and death. Many frameworks chosen to model these systems neglect spatial correlations, which can lead to inaccurate predictions of their behavior. For example, the logistic model is frequently chosen, which is the mean-field approximation in this case. This mean-field description can be corrected by including a system of ordinary differential equations for pairwise correlations between lattice site occupancies at various lattice distances. In this work we discuss difficulties with this method and provide a simplification in the form of a partial differential equation description for the evolution of pairwise spatial correlations over time. We test our simplified model against the more complex corrected mean-field model, finding excellent agreement. We show how our model successfully predicts system behavior in regions where the mean-field approximation shows large discrepancies. Additionally, we investigate regions of parameter space where migration is reduced relative to proliferation, which has not been examined in detail before and find our method is successful at correcting the deviations observed in the mean-field model in these parameter regimes.
authors.affiliation: Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St Giles', Oxford OX1 3LB, United Kingdom. markham@maths.ox.ac.uk
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Markham
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Simpson
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Baker
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D049109:Cell Proliferation; D003198:Computer Simulation; D006801:Humans; D016015:Logistic Models; D008954:Models, Biological