title: Comparison of VEP with contrast sensitivity and other measurements of central visual function.
abstract: OBJECTIVE
  In order to evaluate alternative visual acuity testing techniques, especially to discriminate between small changes and for high visual acuity, we conducted a study covering several state-of-the-art techniques.
  
  
  METHODS
  In this cross-sectional study, a homogeneous cohort of healthy and young patients (n = 33; 66 eyes) underwent ETDRS vision acuity (VA) testing, testing for contrast sensitivity (CS), VA determination with spatial frequency sweep visual evoked potentials (VEP) and a series of examinations of perifoveal retinal nerve fibre layer thickness (RNFLT) using Spectralis SD-OCT. To simulate the effect of artificial media opacity, CS, and VEP were repeated with Bangerter foils.
  
  
  RESULTS
  We found that Bangerter foils can be used to reduce VA effectively measured by VA testing and VEP VA. CS correlated significantly with VA (correlation coefficients ranging from 0.54 to 0.77). VEP may be used to estimate VA; nevertheless, we found no significant correlation. RNFLT did not correlate significantly with VA.
  
  
  CONCLUSIONS
  CS seems to correlate well with VA when used for high VA. All other used examinations seem to have difficulties distinguishing between small differences in VA or when the VA is high.
authors.affiliation: Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Mannheim, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Kromer
authors.forename: Nermin
authors.initials: N
authors.lastname: Serbecic
authors.forename: Hermann
authors.initials: H
authors.lastname: Krastel
authors.forename: Sven C
authors.initials: SC
authors.lastname: Beutelspacher
mesh_terms: D015350:Contrast Sensitivity / Q000502:physiology*; D003430:Cross-Sectional Studies; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology; D055815:Young Adult
keywords: contrast sensitivity; optical coherence tomography; visual acuity; visual evoked potential; visual function