title: Infection in neutropenic patients with cancer.
abstract: Neutropenic fever sepsis syndromes are common among patients with cancer who are receiving intensive cytotoxic systemic therapy. Recognition of the syndromes and timely initial antibacterial therapy is critical for survival and treatment success. Outcomes are linked to myeloid reconstitution and recovery from neutropenia, control of active comorbidities, and appropriate treatment of the infections that underlie the sepsis syndrome. Hematologists and oncologists must be clear about the prognosis and treatment goals to work effectively with critical care physicians toward the best outcomes for patients with cancer who develop neutropenic sepsis syndromes.
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, The University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada. EJBow001@shaw.ca
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Bow
mesh_terms: D018806:APACHE; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D018890:Chemoprevention; D015897:Comorbidity; D003603:Cytotoxins / Q000009:adverse effects* / Q000627:therapeutic use; D005334:Fever; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D009102:Multiple Organ Failure / Q000209:etiology / Q000401:mortality; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications* / Q000382:microbiology / Q000401:mortality; D018805:Sepsis / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D013577:Syndrome
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D003603:Cytotoxins
keywords: Febrile mucositis; Febrile neutropenia; First neutropenic fever; Myelosuppression; Neutropenia; Neutropenic sepsis syndromes; Persistent neutropenic fever; Recrudescent neutropenic fever