title: Effects of crosslinked dextran in hydroxylpropyl methylcellulose on soft tissue augmentation in rats.
abstract: This study compared crosslinked dextrans in hydroxylpropyl methycellulose (DiHMs, pH 5 or 7) with polymethylmethacrylate in bovine collagen (PMMA) and hyaluronic acid (HA) fillers on soft tissue augmentation and safety in rats. HA tended to maintain its size throughout the experimental period but was moveable and friable because of a lack of thick fibroconnective tissue formation. Although, PMMA induced moderately thick fibroconnective tissue formation, its size was decreased markedly from 3-week postimplantation (PI) and became the smallest at 24-month PI. DiHM (pH 7) elicited strong fibrous encapsulation around the filler. Its size decreased slowly but was still considerably maintained at 24-month PI. In contrast, the rate of the DiHM (pH 5) size decrease was slower than that of PMMA, faster DiHM (pH 7), but comparable to HA. Immunohistochemically, types I and III collagens were deposited inside and outside DiHMs (pH 5 and 7). DiHMs (pH 5 and 7), PMMA, and HA showed no adverse reactions. These results suggest that DiHM (pH 7) assures efficacy and safety and is a good candidate for soft tissue augmentation in both humans and animals.
authors.affiliation: Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju, 500-757, Republic of Korea.
authors.forename: Rohani B
authors.initials: RB
authors.lastname: Cena
authors.forename: Jun-Gyu
authors.initials: JG
authors.lastname: Park
authors.forename: Hyun-Jeong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Kyu-Yeol
authors.initials: KY
authors.lastname: Son
authors.forename: Deok-Song
authors.initials: DS
authors.lastname: Kim
authors.forename: Mun-Il
authors.initials: MI
authors.lastname: Kang
authors.forename: Sang-Ik
authors.initials: SI
authors.lastname: Park
authors.forename: Du Geon
authors.initials: du G
authors.lastname: Moon
authors.forename: Dae Yul
authors.initials: DY
authors.lastname: Yang
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Yu
authors.forename: Jae Il
authors.initials: JI
authors.lastname: Lee
authors.forename: Kyoung-Oh
authors.initials: KO
authors.lastname: Cho
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D002417:Cattle; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism; D003238:Connective Tissue / Q000033:anatomy & histology / Q000187:drug effects; D003432:Cross-Linking Reagents; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry*; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry; D065347:Hypromellose Derivatives / Q000737:chemistry*; D008422:Materials Testing; D019904:Polymethyl Methacrylate / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003879:Dermatologic Agents; D003911:Dextrans; D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid; D003094:Collagen; D019904:Polymethyl Methacrylate
keywords: crosslinked dextrans; rat; safety; subcutaneous augmentation