title: [Breast cancer resistance protein and diabetes].
abstract: Diabetes is a group of systematic metabolic diseases. In addition to cytochromes P450s, some ATP-binding cassette drug transporters are also under diabetic conditions. Breast cancer resistance protein (BCRP) , an important member of ATP-binding cassette drug transporters, expressed in most of the tissues, is thought to play an important protective role in normal tissues. It was reported that BCRP function and expression were impaired in intestine of diabetes rats, which affects the absorption and efflux of some drugs. Therefore, the alteration of BCRP expression and activity could be of critical importance for the treatment of diabetes mellitus. In this article, we reviewed the relationship between diabetes and
authors.affiliation: Jiangsu Chia Tai Tianqing Pharmaceutical Co. Ltd. Nanjing 210023, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Liu
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Gu
authors.forename: Sen
authors.initials: S
authors.lastname: Yu
authors.forename: Xi-Quan
authors.initials: XQ
authors.lastname: Zhang
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000502:physiology*; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D009363:Neoplasm Proteins / Q000502:physiology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D007328:Insulin; D015850:Interleukin-6; D009363:Neoplasm Proteins; D014409:Tumor Necrosis Factor-alpha