title: The relationship between single nucleotide polymorphisms of the NTRK2 gene and sporadic Alzheimer's disease in the Chinese Han population.
abstract: Alzheimer's disease (AD) is characterized by the degeneration of basal forebrain cholinergic neurons, whose survival and function are affected by neurotrophins and their receptors. The impaired signaling pathway of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) is considered to play an important role in AD pathogenesis. To explore the association of polymorphisms within the NTRK2 gene (encoding TrkB) and sporadic AD (sAD), a case-control study was conducted in a Chinese Han cohort including 216 sAD patients and 244 control participants. Five single nucleotide polymorphisms (SNPs), with four of them within the promoter region and one in intron, were selected and genotyped with a polymerase chain reaction-ligase detection reaction (PCR-LDR) method. No association was revealed between these SNPs or the haplotypes containing four promoter SNPs and the risk of sAD. The results of this study indicate that polymorphisms in the selected regions of the NTRK2 gene are unlikely to confer the susceptibility of sAD in the Chinese Han population.
authors.affiliation: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital and Institute of Field Surgery, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zeng
authors.forename: Hai-Qiang
authors.initials: HQ
authors.lastname: Zou
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Hong-Yuan
authors.initials: HY
authors.lastname: Cao
authors.forename: Xu
authors.initials: X
authors.lastname: Yi
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Chun-Rong
authors.initials: CR
authors.lastname: Liang
authors.forename: Ye-Ran
authors.initials: YR
authors.lastname: Wang
authors.forename: An-Qiang
authors.initials: AQ
authors.lastname: Zhang
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Tan
authors.forename: Kai-Run
authors.initials: KR
authors.lastname: Peng
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhang
authors.forename: Chang-Yue
authors.initials: CY
authors.lastname: Gao
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Ai-Qing
authors.initials: AQ
authors.lastname: Wen
authors.forename: Yan
authors.initials: Y
authors.lastname: Lian
authors.forename: Xin-Fu
authors.initials: XF
authors.lastname: Zhou
authors.forename: Yan-Jiang
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D020813:Receptor, trkB / Q000235:genetics*
chemical_list: D020813:Receptor, trkB
keywords: Alzheimer's disease; NTRK2; Neurotrophin; Promoter; Single nucleotide polymorphism