title: Ameliorative effect of Noni fruit extract on streptozotocin-induced memory impairment in mice.
abstract: This study evaluated the effects of a standardized ethyl acetate extract of Morinda citrifolia L. (Noni) fruit on impairment of memory, brain energy metabolism, and cholinergic function in intracerebral streptozotocin (STZ)-treated mice. STZ (0.5 mg/kg) was administered twice at an interval of 48 h. Noni (50 and 100 mg/kg, postoperatively) was administered for 21 days following STZ administration. Memory function was evaluated using Morris Water Maze and passive avoidance tests, and brain levels of cholinergic function, oxidative stress, energy metabolism, and brain-derived neurotrophic factor (BDNF) were estimated. STZ caused memory impairment in Morris Water Maze and passive avoidance tests along with reduced brain levels of ATP, BDNF, and acetylcholine and increased acetylcholinesterase activity and oxidative stress. Treatment with Noni extract (100 mg/kg) prevented the STZ-induced memory impairment in both behavioral tests along with reduced oxidative stress and acetylcholinesterase activity, and increased brain levels of BDNF, acetylcholine, and ATP level. The study shows the beneficial effects of Noni fruit against STZ-induced memory impairment, which may be attributed to improved brain energy metabolism, cholinergic neurotransmission, BDNF, and antioxidative action.
authors.affiliation: Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
authors.forename: Shakti D
authors.initials: SD
authors.lastname: Pachauri
authors.forename: Priya Ranjan P
authors.initials: PR
authors.lastname: Verma
authors.forename: Anil K
authors.initials: AK
authors.lastname: Dwivedi
authors.forename: Santoshkumar
authors.initials: S
authors.lastname: Tota
authors.forename: Kiran
authors.initials: K
authors.lastname: Khandelwal
authors.forename: Jitendra K
authors.initials: JK
authors.lastname: Saxena
authors.forename: Chandishwar
authors.initials: C
authors.lastname: Nath
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000235:genetics / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D032066:Morinda; D009043:Motor Activity / Q000187:drug effects; D009573:Nitrites / Q000378:metabolism; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D059808:Polyphenols / Q000627:therapeutic use; D012333:RNA, Messenger / Q000378:metabolism; D011930:Reaction Time / Q000187:drug effects; D013311:Streptozocin / Q000633:toxicity
chemical_list: D000903:Antibiotics, Antineoplastic; D019208:Brain-Derived Neurotrophic Factor; D009573:Nitrites; D010936:Plant Extracts; D059808:Polyphenols; D012333:RNA, Messenger; D008315:Malondialdehyde; D013311:Streptozocin; D000255:Adenosine Triphosphate; D000110:Acetylcholinesterase; D005978:Glutathione; D000109:Acetylcholine