title: [Analysis of the human papillomavirus in laryngeal squamous cell carcinoma patients].
abstract: OBJECTIVE
  To analyze the infection of human papillomavirus in laryngeal squamous cell carcinoma patients.
  
  
  METHODS
  The pathological samples of 64 clinical diagnosed laryngeal squamous cell carcinoma patients were collected. Lunimex and PCR techniques were used to detect the HPV gene infection and immunohistochemistry method was used to analyze the HPV protein expression in the samples.
  
  
  RESULTS
  In the 64 cases, 7 were positive for HPV infection by Luminex and PCR tests. 18 were positive for HPV16/18 E6 protein expression. The total positive rate was about 39. 1%.
  
  
  CONCLUSIONS
  The high HPV infection rate in laryngeal squamous cell carcinoma patients in the study indicated indirectly that the importance of the HPV infection in pathogenesis of the laryngeal squamous cell carcinoma.
authors.affiliation: Head and Neck Surgery Department, Peking University Cancer Hospital & Institute, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Yun-tao
authors.initials: YT
authors.lastname: Song
authors.forename: Bao-yun
authors.initials: BY
authors.lastname: Zhang
authors.forename: Jun-yong
authors.initials: JY
authors.lastname: Sun
authors.forename: Cao
authors.initials: C
authors.lastname: Chen
authors.forename: Nai-song
authors.initials: NS
authors.lastname: Zhang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Dong
authors.forename: Qi
authors.initials: Q
authors.lastname: Shi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics*; D052161:Human papillomavirus 18 / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*
chemical_list: D004279:DNA, Viral