title: A reverse evidence of rotavirus vaccines impact.
abstract: In 2010, and due to a quality problem identified in the vaccine manufacture, the rotavirus (RV) vaccination was withheld in Spain during 5 months. Our study aimed to evaluate the impact that this sudden cease had on rotavirus acute gastroenteritis (RAGE) hospitalizations. An increase in RAGE hospitalization was observed in parallel to the drop in vaccine coverage. Here, we report the first reverse evidence of rotavirus vaccine impact.
authors.affiliation: Área Asistencial Integrada de Pediatría; Hospital Clínico Universitario de Santiago de Compostela; Santiago de Compostela, Spain; Red Gallega de Investigación Pediátrica; Santiago de Compostela, Spain; Grupo de investigación en Genética, Vacunas, Infecciones y Pediatria (GENVIP-www.genvip.org); Instituto de Investigación Sanitaria de Santiago (IDIS); Santiago de Compostela, Spain.
authors.forename: Federico
authors.initials: F
authors.lastname: Martinón-Torres
authors.forename: Angela
authors.initials: A
authors.lastname: Aramburo
authors.forename: Nazareth
authors.initials: N
authors.lastname: Martinón-Torres
authors.forename: Miriam
authors.initials: M
authors.lastname: Cebey
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Seoane-Pillado
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Redondo-Collazo
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Martinón-Sánchez
mesh_terms: D002675:Child, Preschool; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000517:prevention & control*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D056737:Safety-Based Drug Withdrawals; D013030:Spain / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D022243:Rotavirus Vaccines
keywords: Vaccine effectiveness; gastroenteritis/epidemiology; hospitalization; rotavirus infections/prevention & control; rotavirus vaccines