title: Neuropeptides and central control of sexual behaviour from the past to the present: a review.
abstract: Of the numerous neuropeptides identified in the central nervous system, only a few are involved in the control of sexual behaviour. Among these, the most studied are oxytocin, adrenocorticotropin, α-melanocyte stimulating hormone and opioid peptides. While opioid peptides inhibit sexual performance, the others facilitate sexual behaviour in most of the species studied so far (rats, mice, monkeys and humans). However, evidence for a sexual role of gonadotropin-releasing hormone, corticotropin releasing factor, neuropeptide Y, galanin and galanin-like peptide, cholecystokinin, substance P, vasoactive intestinal peptide, vasopressin, angiotensin II, hypocretins/orexins and VGF-derived peptides are also available. Corticotropin releasing factor, neuropeptide Y, cholecystokinin, vasopressin and angiotensin II inhibit, while substance P, vasoactive intestinal peptide, hypocretins/orexins and some VGF-derived peptide facilitate sexual behaviour. Neuropeptides influence sexual behaviour by acting mainly in the hypothalamic nuclei (i.e., lateral hypothalamus, paraventricular nucleus, ventromedial nucleus, arcuate nucleus), in the medial preoptic area and in the spinal cord. However, it is often unclear whether neuropeptides influence the anticipatory phase (sexual arousal and/or motivation) or the consummatory phase (performance) of sexual behaviour, except in a few cases (e.g., opioid peptides and oxytocin). Unfortunately, scarce information has been added in the last 15 years on the neural mechanisms by which neuropeptides influence sexual behaviour, most studied neuropeptides apart. This may be due to a decreased interest of researchers on neuropeptides and sexual behaviour or on sexual behaviour in general. Such a decrease may be related to the discovery of orally effective, locally acting type V phosphodiesterase inhibitors for the therapy of erectile dysfunction.
authors.affiliation: Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. argiolas@unica.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Argiolas
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Melis
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000818:Animals; D004723:Endorphins / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*; D010121:Oxytocin / Q000502:physiology; D012725:Sexual Behavior / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000502:physiology*
chemical_list: D004723:Endorphins; D009479:Neuropeptides; D007987:Gonadotropin-Releasing Hormone; D010121:Oxytocin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones
keywords: ACTH; ACTH-MSH peptides; CRF; GABA; GALP; GH; GnRH/LHRH; LH; MSH; NO; Neuropeptides; Opioid peptides; Oxytocin; PVN; Penile erection; SO; Sexual behaviour; VIP; adrenocorticotropin; corticotropin releasing factor; galanin-like peptide; gamma-amminobutirric acid; gonadotropin releasing hormone; growth hormone; luteinizing hormone; melanocyte stimulating hormone; nitric oxide; paraventricular nucleus of the hypothalamus; supraoptic nucleus; vasoactive intestinal peptide