title: A single center comparison between three different apheresis systems for autologous and allogeneic stem cell collections.
abstract: Three different apheresis systems were used in our center for the collection of peripheral blood progenitor cells (PBPCs): COM.TEC (Fresenius Healthcare), COBE Spectra, and Spectra Optia (both from Caridian BCT). We compared 131 autologous and 56 allogeneic apheresis procedures to elucidate feasibility and effectiveness of the different systems. Collection efficiacy varied significantly with lowest results obtained with COBE Spectra. COM.TEC and Spectra Optia produced lower WBC contamination than COBE Spectra, but at the expense of higher product volume and longer apheresis time. High collection efficacy and a low product volume may be favorable characteristics of the Spectra Optia.
authors.affiliation: Center for Transfusion Medicine and Hemotherapy, University Hospital Giessen and Marburg, Marburg Campus, Baldingerstr., 35043 Marburg, Germany. Electronic address: sabine.flommersfeld@med.uni-marburg.de.
authors.forename: Sabine
authors.initials: S
authors.lastname: Flommersfeld
authors.forename: Tamam
authors.initials: T
authors.lastname: Bakchoul
authors.forename: Gregor
authors.initials: G
authors.lastname: Bein
authors.forename: Almut
authors.initials: A
authors.lastname: Wachtel
authors.forename: Cordula
authors.initials: C
authors.lastname: Loechelt
authors.forename: Ulrich J
authors.initials: UJ
authors.lastname: Sachs
mesh_terms: D000328:Adult; D000368:Aged; D001781:Blood Component Removal / Q000379:methods*; D001804:Blood Transfusion, Autologous / Q000379:methods; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous; D055815:Young Adult
keywords: Apheresis procedures; BW; CE; CR; Collection efficacy; G-CSF; Granulocyte-Colony Stimulating Factor; NHL; Non-Hodgkin lymphoma; PBPCs; PLT; Platelet; Stem cell collection; TPV; Total processed volume; WBC; White Blood Count; body weight; collection efficacy; collection rate; peripheral blood progenitor cells