title: In situ generation of nucleophilic allenes by the gold-catalyzed rearrangement of propargylic esters for the highly diastereoselective formation of intermolecular C(sp3)-C(sp2) bonds.
abstract: New perspectives, in particular for the synthesis of isochromane derivatives (see scheme), are provided by the title reaction. Excellent diastereoselectivites are achieved in this reaction which proceeds through a gold-catalyzed 1,3-acyloxy migration. In some cases exclusively the Z isomer is detected.
authors.affiliation: Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Weibo
authors.initials: W
authors.lastname: Yang
authors.forename: Frank
authors.initials: F
authors.lastname: Rominger
authors.forename: A Stephen K
authors.initials: AS
authors.lastname: Hashmi
keywords: chromanes; gold; homogeneous catalysis; propargyl esters; rearrangement