title: Genetic variations of GAK in two Chinese Parkinson's disease populations: a case-control study.
abstract: Cyclin G-associated kinase (GAK) modifies α-synuclein expression levels and affects the susceptibility of Parkinson's disease (PD). The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations. To date there is only one data with regards to ethnic Chinese from Mainland China. Here, we conducted a case-control study in two independent cohorts of Han Chinese populations from Taiwan and Singapore to validate this association. A total of 1,755 subjects (871 PD patients and 884 controls) were recruited. The results showed that neither the CT, TT genotypes nor the minor allele T of SNP rs1564282 were associated with PD among the subjects from Taiwan and Singapore as well as in the pooled analysis. Differences in our study population with regards to published literature may be due to epigenetic factors and gene-gene or gene-environmental interactions. Further studies in other Chinese populations will be of interest to validate these findings.
authors.affiliation: Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Wei-En Johnny
authors.initials: WE
authors.lastname: Tseng
authors.forename: Chiung-Mei
authors.initials: CM
authors.lastname: Chen
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yi
authors.forename: Eng-King
authors.initials: EK
authors.lastname: Tan
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Wu
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012846:Singapore; D013624:Taiwan
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C486325:GAK protein, human; D017346:Protein Serine-Threonine Kinases