title: Age dependent course of EAE in Aire-/- mice.
abstract: This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6month old mice. In contrast, 2month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.
authors.affiliation: Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Rina
authors.initials: R
authors.lastname: Aharoni
authors.forename: Revital
authors.initials: R
authors.lastname: Aricha
authors.forename: Raya
authors.initials: R
authors.lastname: Eilam
authors.forename: Ido
authors.initials: I
authors.lastname: From
authors.forename: Keren
authors.initials: K
authors.lastname: Mizrahi
authors.forename: Ruth
authors.initials: R
authors.lastname: Arnon
authors.forename: Miriam C
authors.initials: MC
authors.lastname: Souroujon
authors.forename: Sara
authors.initials: S
authors.lastname: Fuchs
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D001921:Brain / Q000276:immunology / Q000503:physiopathology; D002452:Cell Count; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000503:physiopathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013154:Spleen / Q000276:immunology / Q000503:physiopathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology; D013997:Time Factors; D014157:Transcription Factors / Q000172:deficiency* / Q000235:genetics*; D000096927:AIRE Protein
chemical_list: D014157:Transcription Factors; D000096927:AIRE Protein
keywords: Autoimmune regulator (Aire); Autoimmunity; Experimental autoimmune encephalomyelitis (EAE); Regulatory T cells (Treg); Susceptibility