title: Serum adipocyte fatty acid-binding protein levels are independently associated with sarcopenic obesity.
abstract: OBJECTIVE
  Adipocyte fatty acid-binding protein (A-FABP) plays a key role in obesity-related insulin resistance and inflammation which may be involved in the pathogenesis of sarcopenic obesity (SO). This study examined the association of SO with serum A-FABP levels in Korean adults.
  
  
  METHODS
  Two hundred ninety eight adults aged 20-70 years were examined using dual X-ray absorptiometry and computed tomography and measuring serum A-FABP levels. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by weight (%) of <1 SD below the mean values of young adults in both sexes. Obesity was defined as visceral fat area (VFA) ≥ 100 cm(2).
  
  
  RESULTS
  Serum A-FABP levels were higher in groups with SO compared to non-SO groups in both men and women. In the unadjusted model, serum A-FABP levels were positively associated with VFA and negatively associated with ASM/weight. Even after adjusting for possible confounding factors, ASM/weight was found to be independently and negatively associated with serum A-FABP levels. In addition, multiple logistic regression analysis showed that increased serum levels of A-FABP were independently associated with the presence of SO.
  
  
  CONCLUSIONS
  The present findings indicate that serum A-FABP levels may be valuable markers of the presence of SO.
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Haeundaen-gu, Busan, Republic of Korea.
authors.forename: Tae Nyun
authors.initials: TN
authors.lastname: Kim
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Won
authors.forename: You Jeong
authors.initials: YJ
authors.lastname: Kim
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Lee
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Kim
authors.forename: Man Sik
authors.initials: MS
authors.lastname: Park
authors.forename: Seong Keon
authors.initials: SK
authors.lastname: Lee
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Kyung Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Byoung Doo
authors.initials: BD
authors.lastname: Rhee
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D009765:Obesity / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology*; D055948:Sarcopenia / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology*; D055815:Young Adult
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins
keywords: Adipocyte fatty acid-binding protein; Adipokines; Appendicular skeletal muscle mass; Sarcopenic obesity; Visceral obesity