title: Comparing the Immunoexpression of FUT3 and FUT6 between Prostatic Adenocarcinoma and Benign Prostatic Hyperplasia.
abstract: Prostatic Adenocarcinoma (PA) and Benign Prostatic Hyperplasia (BPH) have their etiology not fully understood mainly in glycidic aspects. Glycan changes are associated with cell alterations where glycosylation is carried out by glycosyltransferases, such as fucosyltransferases (FUTs). These enzymes catalyze the insertion of L-fucose residues in a variety of glycan structures often in the final stage of glycosylation. The present study aimed to investigate the expression of FUT3 and FUT6 in PA and BPH as well as to correlate immunostaining of these transferases with PA clinic-histopathologic data. The FUT3 and FUT6 expressions were evaluated by immunohistochemistry in formalin-fixed, paraffin-embedded biopsies of PA (n=40) and BPH (n=40). FUT3 and FUT6 showed a high expression in both prostatic diseases, especially FUT6. FUT6 was more immunoexpressed in PA cases than the FUT3 (p<0.0001) as well as in BPH cases but in a not significant way (p=0.0661). Besides, FUT3 was more expressed in BHP lesion than in PA cases (p<0.0001). Our study presented a new data about FUT3 and FUT6 expression in PA and BPH, revealing high FUT6 expression in both lesions and FUT3 overexpression in BHP in relation to PA, proposing that this enzyme could be a promising biomarker for benign prostate alterations.
authors.affiliation: Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco (UFPE), Av. Prof. Moraes Rêgo, s/n CDU, Recife, PE, Brazil 50670-901.
authors.forename: Juliana Lúcia
authors.initials: JL
authors.lastname: de Albuquerque Vasconcelos
authors.forename: Steffany
authors.initials: S
authors.lastname: de Almeida Ferreira
authors.forename: Amanda Lucena Rosendo
authors.initials: AL
authors.lastname: de Lima
authors.forename: Moacyr Jesus Barreto
authors.initials: MJ
authors.lastname: de Melo Rêgo
authors.forename: Ana Rosa Galdino
authors.initials: AR
authors.lastname: Bandeira
authors.forename: Carmelita
authors.initials: C
authors.lastname: de Lima Bezerra Cavalcanti
authors.forename: Mariana Montenegro
authors.initials: MM
authors.lastname: de Melo Lira
authors.forename: Eduardo Isidoro Carneiro
authors.initials: EI
authors.lastname: Beltrão
keywords: L-fucose; benign prostatic hyperplasia; fucosyltransferases; prostatic adenocarcinoma