title: Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
abstract: A novel series of pyrazoline amidoxime (2a-d) and pyrazoly-1,2,4-oxadiazole (3a-p) and (4) of pharmacological significance have been synthesised. Structures of newly synthesised compounds were characterized by spectral studies. New compounds were screened for their in vitro antioxidant, antimicrobial and antiinflammatory activities. Among the synthesized compounds, compound 2a, 3l and 3o were found to be active antimicrobial agents in addition to having potent antioxidant activity, while the compound 3f showed promising antiinflammatory activity in comparison with standard drug.
authors.affiliation: Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore 570 005, India.
authors.forename: Srikantamurthy
authors.initials: S
authors.lastname: Ningaiah
authors.forename: Umesha K
authors.initials: UK
authors.lastname: Bhadraiah
authors.forename: Shubakara
authors.initials: S
authors.lastname: Keshavamurthy
authors.forename: Chethan
authors.initials: C
authors.lastname: Javarasetty
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001681:Biological Assay; D004353:Drug Evaluation, Preclinical; D005227:Fatty Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000577:Amides; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005227:Fatty Acids; D010069:Oxadiazoles; D010091:Oximes; D011720:Pyrazoles; C013584:lipid peroxidation inhibitor
keywords: Amidoxime; Antiinflammatory; Antimicrobial; Antioxidant; Bis-heterocycles; EDC·HCl