title: New generation of oral mucosal vaccines targeting dendritic cells.
abstract: As most infectious organisms gain entry at mucosal surfaces, there is a great deal of interest in developing vaccines that elicit effective mucosal immune responses against pathogen challenge. Targeted vaccination is one of the most effective methods available to prevent and control infectious diseases. Mucosal vaccines can offer lower costs, better accessibility, needle free delivery, and a higher capacity for mass immunizations during pandemics. Both local mucosal immunity and robust systemic responses can be achieved through mucosal vaccination. Recent progress in understanding the molecular and cellular components of the mucosal immune system have allowed for the development of a novel mucosal vaccine platform utilizing specific dendritic cell-targeting peptides and orally administered lactobacilli to elicit efficient antigen specific immune responses against infections, including Bacillus anthracis in experimental models of disease.
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida, 2015 SW16th Avenue, Gainesville, FL 32608, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Florida, P.O. Box 100214, Gainesville, FL 32610-0214, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Owen
authors.forename: Bikash
authors.initials: B
authors.lastname: Sahay
authors.forename: Mansour
authors.initials: M
authors.lastname: Mohamadzadeh
mesh_terms: D000818:Animals; D000881:Anthrax / Q000276:immunology / Q000517:prevention & control; D001408:Bacillus anthracis / Q000276:immunology; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D005818:Genetic Engineering; D006801:Humans; D018928:Immunity, Mucosal; D007778:Lactobacillus / Q000235:genetics; D010455:Peptides / Q000008:administration & dosage* / Q000276:immunology* / Q000627:therapeutic use; D014611:Vaccination / Q000379:methods; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D010455:Peptides; D014612:Vaccines