title: Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating pH changes.
abstract: We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.
authors.affiliation: CoMPLEX, University College London, London, UK. t.hapuarachchi@ucl.ac.uk.
authors.forename: Tharindi
authors.initials: T
authors.lastname: Hapuarachchi
authors.affiliation: CoMPLEX, University College London, London, UK.
authors.forename: Tracy
authors.initials: T
authors.lastname: Moroz
authors.affiliation: Medical Physics and Bioengineering, University College London, London, UK.
authors.forename: Alan
authors.initials: A
authors.lastname: Bainbridge
authors.affiliation: Medical Physics and Bioengineering, University College London, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Price
authors.affiliation: Medical Physics and Bioengineering, University College London, London, UK.
authors.forename: Ernest
authors.initials: E
authors.lastname: Cady
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, London, UK.
authors.forename: Esther
authors.initials: E
authors.lastname: Baer
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Kevin
authors.initials: K
authors.lastname: Broad
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Ezzati
authors.affiliation: Institute of Neurology, University College London, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Thomas
authors.affiliation: Institute of Neurology, University College London, London, UK.
authors.forename: Xavier
authors.initials: X
authors.lastname: Golay
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Robertson
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, London, UK.
authors.forename: Ilias
authors.initials: I
authors.lastname: Tachtsidis
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D006863:Hydrogen-Ion Concentration; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism / Q000503:physiopathology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008955:Models, Cardiovascular; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013552:Swine
chemical_list: D010100:Oxygen