title: An approach to hyperolactone C and analogues using late stage conjugate addition on an oxonium ylide-derived spirofuranone.
abstract: A stereocontrolled synthesis of norphenyl hyperolactone C together with its utility as a direct precursor to the anti-HIV agent hyperolactone C and analogues by addition of organolithiums, are described. Preliminary studies to access this key building block in a catalytic enantioselective manner are also reported.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. david.hodgson@chem.ox.ac.uk
authors.forename: David M
authors.initials: DM
authors.lastname: Hodgson
authors.forename: Elena
authors.initials: E
authors.lastname: Moreno-Clavijo
authors.forename: Sophie E
authors.initials: SE
authors.lastname: Day
authors.forename: Stanislav
authors.initials: S
authors.lastname: Man
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D008094:Lithium / Q000737:chemistry; D009861:Onium Compounds / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D005663:Furans; D009861:Onium Compounds; C488315:hyperolactone C; C027727:hydronium ion; D008094:Lithium