title: Selection of high efficient transdermal lipid vesicle for curcumin skin delivery.
abstract: Curcumin shows effective anti-inflammatory activities but is seldom used in clinic because of its poor solubility in water and vulnerablity to sunshine ultraviolet effect. Novel lipid vesicles have been developed as carriers for skin delivery. In this paper, lipid vesicles-propylene glycol liposomes (PGL), Ethosomes and traditional liposomes, were prepared as curcumin carriers respectively. Their morphology, particle size and encapsulation efficiency and drug release behavior in vitro were evaluated. Transdermal efficiency and deposition quantity in abdominal skin were also measured with Franz diffusion device. Carrageenan-induced paw edema was established to evaluate the anti-inflammatory effect. From the result, the particle size order of lipid vesicles was: PGL (182.4 ± 89.2 nm)<Ethosomes (289 ± 132.1 nm)<traditional liposomes (632.9 ± 184.1 nm). The order of particle dispersion coefficient was as the same as that of particle size. The sequence of encapsulation efficiency was: PGL>Ethosomes>traditional liposomes. PGL had the best encapsulation efficiency of 92.74 ± 3.44%. From anti-inflammatory experiment, PGL showed the highest and longest inhibition on the development of paw edema, followed by Ethosomes and Traditional liposomes. With the elevated entrapment efficiency, good transdermic ability and sustained-release behavior, PGL may represent an efficient transdermal lipid vesicle for skin delivery.
authors.affiliation: Wenzhou Medical University, Wenzhou City, Zhejiang Province 325035, China.
authors.forename: Ying-Zheng
authors.initials: YZ
authors.lastname: Zhao
authors.forename: Cui-Tao
authors.initials: CT
authors.lastname: Lu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Zhao
authors.forename: Ji-Lai
authors.initials: JL
authors.lastname: Tian
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Xu
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Feng
authors.forename: Chong-Yong
authors.initials: CY
authors.lastname: Xu
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D002351:Carrageenan; D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D004355:Drug Stability; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes; D008297:Male; D010316:Particle Size; D019946:Propylene Glycol / Q000737:chemistry; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D008055:Lipids; D008081:Liposomes; D019946:Propylene Glycol; D002351:Carrageenan; D003474:Curcumin
keywords: Anti-inflammatory effect; Curcumin; Encapsulation efficiency; Transdermal vector