title: Molecular signatures and mechanisms of long-lasting memory consolidation and storage.
abstract: A body of evidence emerged in the last decade regarding late posttraining memory processing. Most of this new information comes from aversively motivated learning tasks that mainly depend on hippocampus, amygdala and insular cortex, and points to the involvement of long-lasting changes in gene expression and protein synthesis in late stages of memory consolidation and storage. Here, we describe recent advances in this field and discuss how recurrent rounds of macromolecular synthesis and its regulation might impact long-term memory storage.
authors.affiliation: Instituto de Biología Celular y Neurociencias, Facultad de Medicina, UBA, Paraguay 2155, 3° piso, Buenos Aires 1121ABG, Argentina.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Katche
authors.forename: Martín
authors.initials: M
authors.lastname: Cammarota
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Medina
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D057567:Memory, Long-Term / Q000502:physiology*; D014176:Protein Biosynthesis / Q000502:physiology*
keywords: Gene expression; Hippocampus; Long-lasting modifications; Memory persistence