title: [Allergy diagnostics in suspected metal implant intolerance].
abstract: Allergy diagnostics may be requested before implantation or in cases of complications by implants. Preimplant allergy testing by patch test should only be done in patients with a reported history of potential allergies to metal or bone cement components and prophetic prophylactic testing should not be done. For baseline diagnostics of suspected implant allergy a patch test with the standard series (containing Ni, Co and Cr preparations) and with bone cement components and peri-implant histology should be performed after exclusion of frequent complication elicitors (in particular low grade infections). This can show a peri-implant T-lymphocyte dominated inflammation. Additional information on a scientific level is given by the lymphocyte transformation test (LTT) assessing metal sensitivity and by peri-implant molecular cytokine profiling giving the inflammatory pattern.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland. Peter.Thomas@med.uni-muenchen.de
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.forename: B
authors.initials: B
authors.lastname: Summer
authors.forename: V
authors.initials: V
authors.lastname: Krenn
authors.forename: M
authors.initials: M
authors.lastname: Thomsen
mesh_terms: D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D007159:Immunologic Tests / Q000379:methods*; D008670:Metals / Q000009:adverse effects*; D019736:Prostheses and Implants / Q000009:adverse effects*
chemical_list: D008670:Metals