title: EGFR gets in the way of microRNA biogenesis.
abstract: Recent studies suggest that microRNA (miRNA) processing is a key regulatory step in the miRNA biogenesis as well as its transcriptional control. In a paper recently published in Nature, Shen et al. revealed that epidermal growth factor receptor (EGFR) directly interacts with argonaute 2 (AGO2), a critical component of RNA-induced silencing complex (RISC), and inhibits the maturation of specific tumor suppressive miRNAs under hypoxic condition.
authors.affiliation: 1] Department of Experimental Therapeutics and The Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA [2] Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita City, Osaka, Japan.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Nishida
authors.forename: Koshi
authors.initials: K
authors.lastname: Mimori
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
mesh_terms: D060565:Argonaute Proteins / Q000737:chemistry* / Q000378:metabolism*; D015687:Cell Hypoxia / Q000502:physiology*; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D060565:Argonaute Proteins; D035683:MicroRNAs; D066246:ErbB Receptors