title: HBV transmission from an occult carrier with five mutations in the major hydrophilic region of HBsAg to an immunosuppressed plasma recipient.
abstract: We describe the case of transmission of an HBsAg-negative hepatitis B infection to an immunosuppressed patient by plasma donation from an HBsAg-negative subject, but with very low serum HBV DNA (about 50 IU/ml) and five mutations in the major hydrophilic region of HBsAg.
authors.affiliation: Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy. nicola.coppola@unina2.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Coppola
authors.forename: Giovanna
authors.initials: G
authors.lastname: Loquercio
authors.forename: Gilda
authors.initials: G
authors.lastname: Tonziello
authors.forename: Rosa
authors.initials: R
authors.lastname: Azzaro
authors.forename: Mariantonietta
authors.initials: M
authors.lastname: Pisaturo
authors.forename: Gaetano
authors.initials: G
authors.lastname: Di Costanzo
authors.forename: Mario
authors.initials: M
authors.lastname: Starace
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pasquale
authors.forename: Carmela
authors.initials: C
authors.lastname: Cacciapuoti
authors.forename: Arnolfo
authors.initials: A
authors.lastname: Petruzziello
mesh_terms: D000368:Aged; D016913:Blood Component Transfusion / Q000009:adverse effects*; D002353:Carrier State / Q000175:diagnosis / Q000821:virology*; D004279:DNA, Viral / Q000097:blood; D006509:Hepatitis B / Q000175:diagnosis* / Q000635:transmission* / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000235:genetics*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D020125:Mutation, Missense; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens
keywords: ALT; HBIG; HBV; HBV infection; HBsAg; HBsAg mutants; MHR; NAT; OBI; Occult HBV infection; PC; Transfusion; alanine amino-transferase; hepatitis B immunoglobulin; hepatitis B surface antigen; hepatitis B virus; major hydrophilic region; nucleic acid amplification technique; occult HBV infection; polymerase chain reaction