title: Proposal for a standardized pathology report of gastroenteropancreatic neuroendocrine tumors: prognostic significance of pathological parameters.
abstract: BACKGROUND
  There is confusion in the diagnosis and biological behaviors of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), because of independently proposed nomenclatures and classifications. A standardized form of pathology report is required for the proper management of patients.
  
  
  METHODS
  We discussed the proper pathological evaluation of GEP-NET at the consensus conference of the subcommittee meeting for the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. We then verified the prognostic significance of pathological parameters from our previous nationwide collection of pathological data from 28 hospitals in Korea to determine the essential data set for a pathology report.
  
  
  RESULTS
  Histological classification, grading (mitosis and/or Ki-67 labeling index), T staging (extent, size), lymph node metastasis, and lymphovascular and perineural invasion were significant prognostic factors and essential for the pathology report of GEP-NET, while immunostaining such as synaptophysin and chromogranin may be optional. Furthermore, the staging system, either that of the 2010 American Joint Cancer Committee (AJCC) or the European Neuroendocrine Tumor Society (ENETS), should be specified, especially for pancreatic neuroendocrine neoplasms.
  
  
  CONCLUSIONS
  A standardized pathology report is crucial for the proper management and prediction of prognosis of patients with GEP-NET.
authors.forename: Mee-Yon
authors.initials: MY
authors.lastname: Cho
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Sohn
authors.forename: So Young
authors.initials: SY
authors.lastname: Jin
authors.forename: Hyunki
authors.initials: H
authors.lastname: Kim
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Jung
authors.forename: Mi-Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Kyoung-Mee
authors.initials: KM
authors.lastname: Kim
authors.forename: Woo Ho
authors.initials: WH
authors.lastname: Kim
authors.forename: Joon Mee
authors.initials: JM
authors.lastname: Kim
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kang
authors.forename: Joon Hyuk
authors.initials: JH
authors.lastname: Choi
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Kang
authors.forename: Youn Wha
authors.initials: YW
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Choi
keywords: Digestive system; Grading; Neuroendocrine tumors; Pathology; Prognosis; Staging