title: Acute and chronic flow-mediated dilation and blood pressure responses to daily intake of boysenberry juice: a preliminary study.
abstract: There is an increasing interest in dietary polyphenols for risk reduction in cardiovascular diseases. The aim of this study was to evaluate acute and chronic flow-mediated dilation (FMD) and blood pressure responses to daily intake of boysenberry juice. FMD of the brachial artery was measured in six subjects in the initial, intermediate and follow-up stages of a 4-week open-label intervention study. The intake of boysenberry juice (180 ml/d) increased FMD with progression of intervention stage, and FMD differed in the follow-up stage compared with pre-intake baseline (p = 0.0163 < 0.0167 = 0.1/6) using Bonferroni correction. Changes in systolic blood pressure (SBP) correlated negatively with SBP before intake only in the follow-up stage (r = -0.961 and p = 0.0007 at 3.5 h), indicating a greater SBP reduction in subjects with higher SBP. These results suggest that daily intake of boysenberry juice is beneficial for reducing cardiovascular risk.
authors.affiliation: Bourbon Institutes of Health Science, Bourbon Corporation , Kashiwazaki City , Japan .
authors.forename: Akito
authors.initials: A
authors.lastname: Matsusima
authors.forename: Ryo
authors.initials: R
authors.lastname: Furuuchi
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sakaguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Goto
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishida
authors.forename: Masao
authors.initials: M
authors.lastname: Hirayama
mesh_terms: D000328:Adult; D000368:Aged; D001628:Beverages; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001916:Brachial Artery; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D004108:Dilatation, Pathologic; D005260:Female; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology; D059808:Polyphenols / Q000494:pharmacology*; D012307:Risk Factors; D027824:Rosaceae / Q000737:chemistry*; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D028321:Plant Preparations; D059808:Polyphenols