title: Risk of retinal vein occlusion in patients with systemic lupus erythematosus: a population-based cohort study.
abstract: OBJECTIVE
  To investigate the risk of developing retinal vein occlusion (RVO) in patients with systemic lupus erythematosus (SLE).
  
  
  METHODS
  In this retrospective population-based cohort study, 6756 patients with SLE and 40 536 controls without SLE (1:6) were selected from the Taiwan National Health Insurance Research Database claims from 2001 to 2006.
  
  
  RESULTS
  The incidence of RVO was 3.46-times higher in the SLE group than in controls (5.61 vs 1.62 per 10 000 person-years) (adjusted HR=3.883, 95% CI 2.299 to 6.558) calculated using Cox proportional hazard regression. Age was an independent risk factor for RVO, with adjusted HRs of 4.842 for individuals aged ≥50 years compared with those 0-49 years. For each age subgroup, the risk of RVO was significantly higher only in the 0-49-year-old SLE group than in controls. In the 0-49-year-old SLE group the incidence of developing RVO was 7.92 times higher (95% CI 3.60 to 17.45) in the SLE group than in the 0-49-year-old controls. In women with SLE, the incidence of developing RVO was 3.33-times higher (95% CI 1.88 to 5.90) than in female controls.
  
  
  CONCLUSIONS
  SLE was significantly associated with an increased risk of developing RVO.
authors.affiliation: Department of Ophthalmology, Chi Mei Medical Centre, Tainan City, Taiwan.
authors.forename: Yung-Chang
authors.initials: YC
authors.lastname: Yen
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Weng
authors.forename: Horng-An
authors.initials: HA
authors.lastname: Chen
authors.forename: Yung-Song
authors.initials: YS
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012170:Retinal Vein Occlusion / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
keywords: Epidemiology; Retina