title: Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?
abstract: The concentration or appearance rate of cancer antigen 125 (CA125) in peritoneal dialysis (PD) effluent has been used for many years as a biomarker for mesothelial cell mass in patients on PD. However, this marker has limitations, and emerging evidence has raised doubts as to its significance. This review explores our current understanding of CA125, its prominent role in studies of "biocompatible" PD solutions, and the ongoing uncertainty concerning its interpretation as a measure of mesothelial cell health.
authors.affiliation: Division of Nephrology, University Health Network, and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Harpaul
authors.initials: H
authors.lastname: Cheema
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Bargman
mesh_terms: D015415:Biomarkers; D018394:CA-125 Antigen; D016923:Cell Death; D049109:Cell Proliferation; D015314:Dialysis Solutions / Q000737:chemistry*; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D010530:Peritoneal Dialysis
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; D015314:Dialysis Solutions
keywords: CA125; Cancer antigen 125; biocompatibility; biomarkers; mesothelial cell mass; peritonitis