title: Study of drug-eluting coating on metal coronary stent.
abstract: Drug-eluting stent has been proved to decrease the restenosis caused by the stent implantation, owing to the existence of a drug-eluting coating on the stent. For ensuring the effectivity and security of the drug-eluting stent during the service period, the uniform surface, good deformation and stabilized drug release behavior of the stents should be satisfied. In this study, the performances mentioned were studied on stainless steel stents. The results showed that the surface morphology of the coating was affected by the sorts of solvent, the parameters of the spraying process and the addition of the plasticizer. The drug-eluting profile of the coating was influenced by the plasticizer content and PLGA/drug ratio of the coating. Meanwhile, the plasticizer as an additional agent obviously increased the deformation performance of the coating. Optimized parameters for preparation of the drug-eluting coating were investigated to obtain a drug-eluting coating with good integrated performances.
authors.affiliation: Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Shanshan
authors.forename: Tan
authors.initials: T
authors.lastname: Lili
authors.forename: Teng
authors.initials: T
authors.lastname: Yingxue
authors.forename: Zhang
authors.initials: Z
authors.lastname: Bingchun
authors.forename: Yang
authors.initials: Y
authors.lastname: Ke
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D054855:Drug-Eluting Stents; D019344:Lactic Acid / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012212:Rheology; D012399:Rotation; D020123:Sirolimus / Q000494:pharmacology; D012996:Solutions; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D008670:Metals; D012996:Solutions; D012997:Solvents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D020123:Sirolimus
keywords: Coating; Deformation; Drug releasing behavior; Drug-eluting stent; Surface morphology