title: Aqueous-based immobilization of initiator and surface-initiated ATRP to construct hemocompatible surface of poly (styrene-b-(ethylene-co-butylene)-b-styrene) elastomer.
abstract: Surface-initiated atom transfer radical polymerization (SI-ATRP) is a versatile tool for surface functionalization in a well-controlled manner. However, surface modification of styrenic thermoplastic elastomers (STPEs) faces a great challenge because immobilization of typical ATRP initiators onto STPEs needs to be carried out in organic solvent, which dissolves and destroys the STPEs film. In this work, a simple aqueous-based route is developed to immobilize ATRP initiators, Br, onto the surface of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS), chosen as a model copolymer of STPEs. In such a way, functional polymer brushes of ethylene glycol methyl ether methacrylate (OEGMA) are successfully prepared from the surface of SEBS. Kinetic investigations show an approximately linear relationship between grafting density and reaction time, indicating the growth of chains is coincident with a "controlled" process. CBr bonds directly connected to benzene rings on the SEBS-Br surfaces are demonstrated to be effective initiation sites for SI-ATRP. The even coverage of the surface by well-defined P(OEGMA) brushes enable SEBS films to exhibit excellent resistance to protein adsorption and platelet adhesion as well as low hemolysis ratio. This work not only manipulates the SEBS surface to substantially improve its biocompatibility, but paves a way to facilitate SI-ATRP on the surface of styrene-based block copolymers (SBCs).
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Hou
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: shiqiang@ciac.jl.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Istituto per lo Studio delle Macromolecole, UOS Genova, Consiglio Nazionale delle Ricerche, Via De Marini 6, 16149 Genova, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Stagnaro
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.affiliation: Istituto per lo Studio delle Macromolecole, UOS Genova, Consiglio Nazionale delle Ricerche, Via De Marini 6, 16149 Genova, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Conzatti
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: yinjh@ciac.jl.cn.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yin
mesh_terms: D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D020724:Elastomers / Q000737:chemistry*; D054879:Halogenation; D006461:Hemolysis / Q000187:drug effects; D008689:Methacrylates / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D010973:Platelet Adhesiveness / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry; D011095:Polyethylenes / Q000737:chemistry*; D058105:Polymerization; D011137:Polystyrenes / Q000737:chemistry*; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D020724:Elastomers; D008689:Methacrylates; D011095:Polyethylenes; D011137:Polystyrenes; C524499:polyethylene glycol methacrylate; D014867:Water; C050192:styrene-ethylene-butylene-styrene-block copolymer; D011092:Polyethylene Glycols
keywords: Aqueous-based route; Hemocompatibility; Initiator immobilization; SEBS; Surface-initiated ATRP