title: Spatial and temporal dynamics of neurite regrowth.
abstract: Injury to mature neurites triggers a series of events that have both growth promoting and inhibitory roles. Recent evidence from a variety of experimental models has revealed new neuronal re-growth modulators. The action of these modulators must be precisely regulated both in time and space, and involves multiple cellular processes including retrograde signaling and local translation in the injured neurite. New genetic techniques, in combination with pharmacological approaches, have served to advance mechanistic dissection of neuronal response to injury. Better understanding of the spatio-temporal cues would greatly aid in the development of effective regenerative therapies.
authors.affiliation: Division of Biological Sciences, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA; Biology Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Naina
authors.initials: N
authors.lastname: Kurup
authors.forename: Panid
authors.initials: P
authors.lastname: Sharifnia
authors.forename: Yishi
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000818:Animals; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D016501:Neurites / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D020930:MAP Kinase Kinase Kinases; C090757:mitogen-activated protein kinase kinase kinase 12