title: Plaque vulnerability of coronary artery lesions is related to left ventricular dilatation as determined by optical coherence tomography and cardiac magnetic resonance imaging in patients with type 2 diabetes.
abstract: BACKGROUND
  Patients with type 2 diabetes are at increased risk for both, left ventricular (LV)-dilatation and myocardial infarction (MI) following the rupture of a vulnerable plaque. This study investigated the to date incompletely understood relationship between plaque vulnerability and LV-dilatation using optical coherence tomography (OCT) and cardiac magnetic resonance imaging (CMR) in patients with type 2 diabetes and stable coronary artery disease.
  
  
  METHODS
  CMR was performed in 58 patients with type 2 diabetes, in which 81 coronary lesions were investigated using OCT.
  
  
  RESULTS
  A decreased minimal fibrous cap thickness (FCT) of coronary lesions was associated with an increase of several CMR-derived parameters including LV-end diastolic volume (LVEDV, r = 0.521, p < 0.001), LV-end diastolic diameter (r = 0.502, p < 0.001) and LV-end systolic volume (r = 0.467, p = 0.001). Similar results were obtained for mean FCT.
  
  
  CONCLUSIONS
  These data suggest that vulnerability of coronary lesions is associated with LV-dilatation in high risk patients with type 2 diabetes. CMR may be a useful adjunct to the risk-stratification in this population. Future studies are warranted to investigate potential mechanisms linking plaque vulnerability and LV-dilatation.
authors.forename: Mathias
authors.initials: M
authors.lastname: Burgmaier
authors.forename: Michael
authors.initials: M
authors.lastname: Frick
authors.forename: Ana
authors.initials: A
authors.lastname: Liberman
authors.forename: Simone
authors.initials: S
authors.lastname: Battermann
authors.forename: Martin
authors.initials: M
authors.lastname: Hellmich
authors.forename: Walter
authors.initials: W
authors.lastname: Lehmacher
authors.forename: Agnes
authors.initials: A
authors.lastname: Jaskolka
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Marx
authors.forename: Sebastian
authors.initials: S
authors.lastname: Reith
mesh_terms: D000368:Aged; D019540:Area Under Curve; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005355:Fibrosis; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors; D012422:Rupture, Spontaneous; D013318:Stroke Volume; D041623:Tomography, Optical Coherence; D016277:Ventricular Function, Left