title: The hematopoietic cell transplantation specific comorbidity index and survival after extracorporeal photopheresis, pentostatin, and reduced dose total body irradiation conditioning prior to allogeneic stem cell transplantation.
abstract: Hematopoietic-cell-transplantation-specific-comorbidity-index (HCT-CI) has been reported as a predictor of survival in allogeneic-transplant recipients; however its validity has recently been challenged. We evaluated the association of HCT-CI with survival of transplant recipients who underwent reduced-intensity-conditioning (RIC) with photopheresis, pentostatin, and total-body-irradiation. Median age of 103 patients selected was 55 years. Most patients (58.3%) had high (≥ 3) HCT-CI. Median OS was 298 days. Age, disease-type, disease-status, HCT-CI correlated with survival on bivariate analysis. On multivariate analysis, only HCT-CI was significantly associated with OS (low HCT-CI HR=0.29, CI 0.091-0.886; intermediate HCT-CI HR=0.41, CI 0.226-0.752). Our findings suggest HCT-CI as an independent predictor of survival in the setting of RIC transplants.
authors.affiliation: Mayo Clinic Transplant Center, Blood and Marrow Transplant Program, Mayo Clinic, Rochester, MN, United States. Hashmi.Shahrukh@mayo.edu
authors.forename: Shahrukh
authors.initials: S
authors.lastname: Hashmi
authors.forename: Jamie L
authors.initials: JL
authors.lastname: Oliva
authors.forename: Jane L
authors.initials: JL
authors.lastname: Liesveld
authors.forename: Gordon L
authors.initials: GL
authors.lastname: Phillips
authors.forename: Laurie
authors.initials: L
authors.lastname: Milner
authors.forename: Michael W
authors.initials: MW
authors.lastname: Becker
mesh_terms: D000368:Aged; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000401:mortality* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D015649:Pentostatin / Q000627:therapeutic use*; D017893:Photopheresis; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D015996:Survival Rate; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation
chemical_list: D015649:Pentostatin
keywords: Hematopoietic cell transplantation specific comorbidity index; Non-relapse mortality; Overall survival; Reduced intensity conditioning