title: The role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation.
abstract: During normal postnatal mammary gland development and adult remodeling related to the menstrual cycle, pregnancy, and lactation, ovarian hormones and peptide growth factors contribute to the delineation of a definite epithelial cell identity. This identity is maintained during cell replication in a heritable but DNA-independent manner. The preservation of cell identity is fundamental, especially when cells must undergo changes in response to intrinsic and extrinsic signals. The maintenance proteins, which are required for cell identity preservation, act epigenetically by regulating gene expression through DNA methylation, histone modification, and chromatin remodeling. Among the maintenance proteins, the Trithorax (TrxG) and Polycomb (PcG) group proteins are the best characterized. In this review, we summarize the structures and activities of the TrxG and PcG complexes and describe their pivotal roles in nuclear estrogen receptor activity. In addition, we provide evidence that perturbations in these epigenetic regulators are involved in disrupting epithelial cell identity, mammary gland remodeling, and breast cancer initiation.
authors.affiliation: Department of Clinical and Community Health Sciences, Medical Statistics, Biometry and Bioinformatics, University of Milan 20133, Italy. danila.coradini@yahoo.it.
authors.forename: Danila
authors.initials: D
authors.lastname: Coradini
authors.forename: Saro
authors.initials: S
authors.lastname: Oriana
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D002471:Cell Transformation, Neoplastic; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology*; D005260:Female; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D008321:Mammary Glands, Animal / Q000166:cytology / Q000254:growth & development; D042361:Mammary Glands, Human / Q000166:cytology / Q000254:growth & development; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics / Q000502:physiology*; D063146:Polycomb-Group Proteins / Q000235:genetics / Q000502:physiology*; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: D002843:Chromatin; C497422:KMT2A protein, human; D063146:Polycomb-Group Proteins; D011960:Receptors, Estrogen; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase