title: MicroRNAs and metabolism crosstalk in energy homeostasis.
abstract: In record time, microRNAs (miRNAs) have acquired the respected stature of important natural regulators of global gene expression. Multiple studies have demonstrated that a large number of miRNAs are under the control of various metabolic stimuli, including nutrients, hormones, and cytokines. Conversely, it is now well recognized that miRNAs control metabolism, thereby generating a bidirectional functional link, which perturbs energy homeostasis in case of disconnection in the miRNA-metabolism interplay. A challenging road lies ahead for defining the role of miRNAs in the pathogenesis of diseases such as diabetes and for establishing their usefulness as new medications and clinically reliable biomarkers.
authors.affiliation: INSERM U1081, Aging and Diabetes team, Institute for Research on Cancer and Aging, Nice (IRCAN), 06107 Nice, France; CNRS UMR7284, Institute for Research on Cancer and Aging, Nice (IRCAN), 06107 Nice, France; University of Nice-Sophia Antipolis, 06100 Nice, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Dumortier
authors.forename: Charlotte
authors.initials: C
authors.lastname: Hinault
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Van Obberghen
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology; D004734:Energy Metabolism; D006728:Hormones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D006728:Hormones; D035683:MicroRNAs