title: The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular disease.
abstract: Resveratrol is a naturally occurring polyphenol found in the skin of red grapes, peanuts, and red wine that has been shown to modify many cardiovascular risk factors. Small animal models have been extensively used to investigate cardiovascular disease, but the results often fail to translate in clinical trials. Disease-specific pig models are emerging as clinically useful tools that may offer insight into cardiovascular disease and the effect of drugs such as resveratrol on cardiovascular health. In this paper, we discuss the advantage of using clinically relevant pig models of diabetes, hypercholesterolemia, and myocardial ischemia to investigate the role of resveratrol in cardiovascular disease prevention.
authors.affiliation: Division of Cardiothoracic Surgery, Cardiovascular Research Center, Warren Alpert School of Medicine, Brown University, Providence, RI 02905, USA.
authors.forename: Nassrene Y
authors.initials: NY
authors.lastname: Elmadhun
authors.forename: Ashraf A
authors.initials: AA
authors.lastname: Sabe
authors.forename: Michael P
authors.initials: MP
authors.lastname: Robich
authors.forename: Louis M
authors.initials: LM
authors.lastname: Chu
authors.forename: Antonio D
authors.initials: AD
authors.lastname: Lassaletta
authors.forename: Frank W
authors.initials: FW
authors.lastname: Sellke
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000378:metabolism / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control*; D004195:Disease Models, Animal; D006801:Humans; D000077185:Resveratrol; D013045:Species Specificity; D013267:Stilbenes / Q000378:metabolism / Q000627:therapeutic use*; D013552:Swine; D016896:Treatment Outcome
chemical_list: D002316:Cardiotonic Agents; D013267:Stilbenes; D000077185:Resveratrol
keywords: cardiovascular disease; metabolic syndrome; myocardial ischemia; pig model; resveratrol