title: The immune network in pancreatic cancer development and progression.
abstract: The presence of stromal desmoplasia is a hallmark of spontaneous pancreatic ductal adenocarcinoma, forming a unique microenvironment that comprises many cell types. Only recently, the immune system has entered the pathophysiology of pancreatic ductal adenocarcinoma development. Tumor cells in the pancreas seem to dysbalance the immune system, thus facilitating spontaneous cancer development. This review will try to assemble all relevant data to demonstrate the implications of the immune network on spontaneous cancer development.
authors.affiliation: Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: S M
authors.initials: SM
authors.lastname: Wörmann
authors.affiliation: Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: K N
authors.initials: KN
authors.lastname: Diakopoulos
authors.affiliation: Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Lesina
authors.affiliation: Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Algül
mesh_terms: D056704:Adaptive Immunity; D021441:Carcinoma, Pancreatic Ductal / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D022423:Myeloid Cells / Q000276:immunology; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D051192:Receptors, Pattern Recognition / Q000276:immunology; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines; D051192:Receptors, Pattern Recognition