title: Triglycerides-diabetes association in healthy middle-aged men: modified by physical fitness? A long term follow-up of 1962 Norwegian men in the Oslo Ischemia Study.
abstract: OBJECTIVE
  To examine the impact of physical fitness (PF) on the association between fasting serum triglycerides (FTG) and diabetes risk and whether temporal changes in FTG predict diabetes risk in healthy middle-aged men.
  
  
  METHODS
  FTG and PF (bicycle exercise test) were measured in 1962 men aged 40-59 years in 1972-1975 (Survey 1) and repeated in 1387 still healthy men on average 7.3 years later (Survey 2). Diabetes was diagnosed according to WHO 1985-criteria.
  
  
  RESULTS
  During 35 years follow-up 202/1962 (10.3%) men developed diabetes. Compared with the lowest, the upper FTG tertile had a 2.58-fold (95% CI: 1.81-3.74) diabetes risk adjusted for age, fasting blood glucose and maternal diabetes, and a 2.29-fold (95%CI: 1.60-3.33) when also adjusting for PF. Compared with unchanged (±25%) FTG levels (n=664), FTG reduction of more than 25% (n=261) was associated with 56% lower (0.44; 95% CI: 0.24-0.75) diabetes risk, while FTG increase of more than 25% (n=462) was associated with similar risk. These associations were unchanged when adjusted for PF and PF change.
  
  
  CONCLUSIONS
  High FTG-levels predicted long-term diabetes risk in healthy middle-aged men, and the association was only modestly weakened when adjusted for PF. A reduction in FTG was associated with decreased diabetes risk.
authors.affiliation: Department of Cardiology, Oslo University Hospital, Ullevaal, Norway. torger.skretteberg@medisin.uio.no
authors.forename: P T
authors.initials: PT
authors.lastname: Skretteberg
authors.forename: A N
authors.initials: AN
authors.lastname: Grytten
authors.forename: K
authors.initials: K
authors.lastname: Gjertsen
authors.forename: I
authors.initials: I
authors.lastname: Grundvold
authors.forename: S E
authors.initials: SE
authors.lastname: Kjeldsen
authors.forename: J
authors.initials: J
authors.lastname: Erikssen
authors.forename: L
authors.initials: L
authors.lastname: Mellbin
authors.forename: K
authors.initials: K
authors.lastname: Liestøl
authors.forename: D A
authors.initials: DA
authors.lastname: Fraser
authors.forename: G
authors.initials: G
authors.lastname: Erikssen
authors.forename: T R
authors.initials: TR
authors.lastname: Pedersen
authors.forename: J
authors.initials: J
authors.lastname: Bodegard
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D010809:Physical Fitness / Q000502:physiology*; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides
keywords: BMI; DAGs; Diabetes; Epidemiology; FBG; FTG; Fitness; HDL-c; HDL-cholesterol; Lipids; PA; PF; Prediction; T; TG; body mass index (kg/m(2)); directed acyclic graph approach; fasting blood glucose; fasting serum triglycerides; physical activity; physical fitness; tertile; triglycerides