title: Aminosilane as an effective binder for hydroxyapatite-gelatin nanocomposites.
abstract: Aminosilane has been explored as an alternative chemical linker to facilitate the binding and solidification of hydroxyapatite-gelatin nanocomposite at room temperature, which was synthesized using co-precipitation method in the presence of gelatin. This aminosilane treatment was found effective at low concentration (~25 μL/mL) and the solidification and dehydration of hydroxyapatite-gelatin slurry completes within hours depending on the amount of aminosilane. The resulting sample exhibits compressive strength of 133 MPa, about 40% higher than glutaraldehyde treated samples, and shows good biocompatibility based on cell adhesion, proliferation, alkaline phosphate synthesis, and mineralization studies.
authors.affiliation: Department of Materials Science and Engineering, North Carolina State University, Raleigh, NC 27695, USA Mark_Luo@ncsu.edu.
authors.forename: Tzy-Jiun M
authors.initials: TJ
authors.lastname: Luo
authors.forename: Ching-Chang
authors.initials: CC
authors.lastname: Ko
authors.forename: Chi-Kai
authors.initials: CK
authors.lastname: Chiu
authors.forename: Jacob
authors.initials: J
authors.lastname: Llyod
authors.forename: Uk
authors.initials: U
authors.lastname: Huh
keywords: Aminosilane Hydroxyapatite; Biomaterials; Nanocomposite; Osteoblast