title: Lemierre syndrome associated with 12th cranial nerve palsy--a case report and review.
abstract: Since the widespread availability and use of antibiotics the prevalence of Lemierre syndrome (L.S.) has decreased. It is a well-described entity, consisting of postanginal septicaemia with thrombophlebitis of the internal jugular vein with metastatic infection, most commonly in the lungs. The most common causative agent is a gram-negative, non-spore-forming obligate anaerobic bacterium, Fusobacterium necrophorum (F.n.). We describe the unusual clinical features of a 12-year-old boy with Lemierre syndrome with isolated hypoglossal nerve palsy - the latter symptom is an extremely rare manifestation of this disease.
authors.affiliation: Centre for Pediatrics and Adolescent Medicine, University Hospital Freiburg, Germany. kerstin.blessing@uniklinik-freiburg.de
authors.forename: Kerstin
authors.initials: K
authors.lastname: Blessing
authors.forename: Nicole
authors.initials: N
authors.lastname: Toepfner
authors.forename: Susanne
authors.initials: S
authors.lastname: Kinzer
authors.forename: Cornelia
authors.initials: C
authors.lastname: Möllmann
authors.forename: Julia
authors.initials: J
authors.lastname: Geiger
authors.forename: Annerose
authors.initials: A
authors.lastname: Serr
authors.forename: Markus
authors.initials: M
authors.lastname: Hufnagel
authors.forename: Christoph
authors.initials: C
authors.lastname: Müller
authors.forename: Marcus
authors.initials: M
authors.lastname: Krüger
authors.forename: Gerd J
authors.initials: GJ
authors.lastname: Ridder
authors.forename: Reinhard
authors.initials: R
authors.lastname: Berner
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D016638:Critical Illness / Q000628:therapy; D005500:Follow-Up Studies; D005674:Fusobacterium Infections / Q000175:diagnosis* / Q000188:drug therapy; D005675:Fusobacterium necrophorum / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D020437:Hypoglossal Nerve Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D007362:Intensive Care Units; D057831:Lemierre Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D035583:Rare Diseases; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: Fusobacterium necrophorum; Lemierre syndrome; Postanginal septicaemia; Septic emboli; Thrombophlebitis