title: Flexibilisquinone, a new anti-inflammatory quinone from the cultured soft coral Sinularia flexibilis.
abstract: A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. yvonne6819@yahoo.com.tw
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Lin
authors.forename: Chao-Ying
authors.initials: CY
authors.lastname: Kuo
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Yen-You
authors.initials: YY
authors.lastname: Lin
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000378:metabolism*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D051546:Cyclooxygenase 2 / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D011809:Quinones; C586221:flexibilisquinone; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2