title: Antioxidant activity of herbal polysaccharides and cough reflex.
abstract: The extraction of Fallopia sachalinensis leaves resulted in two fractions (FS-1 and FS-2). Chemical and spectral analyses of samples revealed the prevalence of pectic polysaccharides with high galacturonic acid, arabinose, galactose, and rhamnose content. Arabinogalactan with a higher content of phenolic prevailed in the FS-1, whereas rhamnogalacturonan predominated in the FS-2 fraction. Both polysaccharides showed significant antioxidant activity according to DPPH and FRAP assays. Evaluation of antitussive activity in healthy adult conscious guinea pigs after oral application of 50 and 75 mg/kg of the FS-2 polysaccharide extracts showed a significant suppression of cough reflex, without an influence on specific airway resistance. The suppression of cough was comparable with that of codeine.
authors.affiliation: Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, 26 Sklabinska St., 036 01, Martin, Slovakia, vsadlonova@jfmed.uniba.sk.
authors.forename: G
authors.initials: G
authors.lastname: Nosalova
authors.forename: L
authors.initials: L
authors.lastname: Jurecek
authors.forename: Z
authors.initials: Z
authors.lastname: Hromadkova
authors.forename: Z
authors.initials: Z
authors.lastname: Kostalova
authors.forename: V
authors.initials: V
authors.lastname: Sadlonova
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000996:Antitussive Agents / Q000494:pharmacology; D001089:Arabinose / Q000737:chemistry; D003371:Cough / Q000188:drug therapy* / Q000378:metabolism; D005690:Galactose / Q000737:chemistry; D006168:Guinea Pigs; D006603:Hexuronic Acids / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011134:Polysaccharides / Q000378:metabolism*; D012210:Rhamnose / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000975:Antioxidants; D000996:Antitussive Agents; D006603:Hexuronic Acids; D010936:Plant Extracts; D011134:Polysaccharides; D014867:Water; C007819:galacturonic acid; D001089:Arabinose; D012210:Rhamnose; D005690:Galactose