title: [Preventive trial of preheating administration of oxaliplatin-diluted solution in combination with a hot compress for oxaliplatin-induced venous pain].
abstract: Venous pain induced by oxaliplatin (L-OHP) is a clinical problem in relation to adherence in the CapeOX regimen. We investigated the preventive effect of nursing care preheating administration of L-OHP a hot compress for colorectal cancer patients who received L-OHP via the peripheral venous route between January 2010 and January 2011. L-OHP was diluted in 500 mL of 5% glucose and administered by 2 hours. We evaluated a total of 64 courses among fifteen patients. The presence of any symptoms, any pain with or without touch, and some symptoms of numbness at the L-OHP-administered arm were defined as phlebitis, venous pain, and acute peripheral neuropathy, respectively. The prevalence of phlebitis, venous pain, and acute peripheral neuropathy in the nursing care group was 56.5%, 32.6%, and 25.8%, respectively, which was not significantly less in comparison with the control group (72.2%, 38.9%, and 54.5%, respectively). These results suggest that both types of nursing care, preheating administration and a hot compress, may be effective for the relief of acute peripheral neuropathy induced by L-OHP.
authors.affiliation: Ambulatory Treatment Center, Ehime University Hospital.
authors.forename: Risa
authors.initials: R
authors.lastname: Miyajima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kawazoe
authors.forename: Kikue
authors.initials: K
authors.lastname: Tsuneoka
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Fujiwara
authors.forename: Yoh
authors.initials: Y
authors.lastname: Kojima
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yakushijin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000698:Analgesia / Q000379:methods; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D000077150:Oxaliplatin; D010523:Peripheral Nervous System Diseases / Q000451:nursing*; D011312:Pressure; D012996:Solutions; D014680:Veins
chemical_list: D009944:Organoplatinum Compounds; D012996:Solutions; D000077150:Oxaliplatin