title: The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications.
abstract: There is growing interest in the ability of the intestinal microbiome to influence host function within and beyond the gastrointestinal tract. Here we review evidence of microbiome-brain interactions in mice and focus on the ability to transfer behavioral traits between mouse strains using fecal microbiota transplantation (FMT). Transplantation alters brain chemistry and behavior in recipient ex-germ free mice, raising the possibility of using FMT for disorders of the central nervous system, and prompting caution in the selection of FMT donors for conditions that may include refractory Clostridium difficile infection, diabetes and inflammatory bowel disease in humans.
authors.affiliation: Farncombe Family Digestive Health Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. scollins@mcmaster.ca
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Collins
authors.forename: Zain
authors.initials: Z
authors.lastname: Kassam
authors.forename: Premysl
authors.initials: P
authors.lastname: Bercik
mesh_terms: D000818:Animals; D001691:Biological Therapy / Q000379:methods*; D001921:Brain / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000628:therapy; D003015:Clostridium Infections / Q000628:therapy; D003920:Diabetes Mellitus / Q000628:therapy; D041981:Gastrointestinal Tract / Q000382:microbiology*; D015212:Inflammatory Bowel Diseases / Q000628:therapy; D051379:Mice; D064307:Microbiota