title: Multi-modality imaging findings of methotrexate-related Epstein-Barr virus-associated hepatic tumor.
abstract: Methotrexate (MTX)-associated lymphoproliferative disorders (MTX-LPDs) that occur in rheumatoid arthritis patients who were administered MTX for long periods are well known. However, studies on their pathology in forming hepatic tumors are rare. An approach using diagnostic imaging modalities, mainly computed tomography (CT), is considered a very useful tool for the differential diagnosis of various hepatic tumors. In the present study, detailed findings of dynamic CT, magnetic resonance (MR) imaging, and contrast-enhanced ultrasonography of a hepatic tumor that was confirmed as infected by Epstein-Barr virus, in a rheumatoid arthritis patient administered MTX are presented.
authors.affiliation: Department of Radiology, UBE INDUSTRIES, LTD. Central Hospital, 750 Nishikiwa, Ube, Yamaguchi 755-0151, Japan. Electronic address: r34tfuji@solid.ocn.ne.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tanabe
authors.forename: Etsushi
authors.initials: E
authors.lastname: Iida
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Okimoto
authors.forename: Naofumi
authors.initials: N
authors.lastname: Matsunaga
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D004854:Herpesvirus 4, Human; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D008223:Lymphoma / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D064847:Multimodal Imaging
chemical_list: D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D008727:Methotrexate
keywords: Epstein-Barr virus; Hepatic tumor; Methotrexate; computed tomography