title: Evaluation of ovarian function in 35-40-year-old women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To assess gonadotrophin secretion, ovarian steroid production and ovarian reserve in PCOS women during the onset of reproductive decline, in order to characterize their ovarian function at this age.
  
  
  METHODS
  Forty PCOS patients and 35 healthy women (35-40 years of age) were included. Clinical history, anthropometry, transvaginal ultrasound and a leuprolide acetate test (10 μg/kg s.c.) were performed. Gonadotrophins, steroid hormones, SHBG, inhibin B and AMH were determined.
  
  
  RESULTS
  Basal and peak LH levels were similar in both groups. Basal and peak FSH levels were significantly higher in the control group. Androgens, peak oestradiol, ovarian volume, antral follicle count and AMH levels were significantly higher in PCOS patients.
  
  
  CONCLUSIONS
  These observations suggest that during late reproductive age, gonadotrophin secretion in women with PCOS is clearly different from that observed in control women and may also differ from that of younger PCOS patients. New features like normal LH and lower FSH levels associated with a higher ovarian reserve may give a different reproductive profile to these women.
authors.affiliation: Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile.
authors.forename: Amanda Ladrón
authors.initials: AL
authors.lastname: de Guevara
authors.forename: Nicolás
authors.initials: N
authors.lastname: Crisosto
authors.forename: Bárbara
authors.initials: B
authors.lastname: Echiburú
authors.forename: Jessica
authors.initials: J
authors.lastname: Preisler
authors.forename: Natalie
authors.initials: N
authors.lastname: Vantman
authors.forename: Josefina
authors.initials: J
authors.lastname: Bollmann
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez-Bravo
authors.forename: Teresa
authors.initials: T
authors.lastname: Sir-Petermann
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D054304:Anti-Mullerian Hormone / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000166:cytology / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*
chemical_list: D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Gonadal axis; Late reproductive age; Ovarian reserve; Polycystic ovary syndrome