title: Chronic obstructive pulmonary disease assessment test can predict depression: a prospective multi-center study.
abstract: This study was conducted to investigate the association between the chronic obstructive pulmonary disease (COPD) assessment test (CAT) and depression in COPD patients. The Korean versions of the CAT and patient health questionnaire-9 (PHQ-9) were used to assess COPD symptoms and depressive disorder, respectively. In total, 803 patients with COPD were enrolled from 32 hospitals and the prevalence of depression was 23.8%. The CAT score correlated well with the PHQ-9 score (r=0.631; P<0.001) and was significantly associated with the presence of depression (β±standard error, 0.452±0.020; P<0.001). There was a tendency toward increasing severity of depression in patients with higher CAT scores. By assessment groups based on the 2011 Global Initiative for Chronic Obstructive Lung Disease guidelines, the prevalence of depression was affected more by current symptoms than by airway limitation. The area under the receiver operating characteristic curve for the CAT was 0.849 for predicting depression, and CAT scores ≥21 had the highest accuracy rate (80.6%). Among the eight CAT items, energy score showed the best correlation and highest power of discrimination. CAT scores are significantly associated with the presence of depression and have good performance for predicting depression in COPD patients.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Lee
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Park
authors.forename: Yeon-Mok
authors.initials: YM
authors.lastname: Oh
authors.forename: Sang-Do
authors.initials: SD
authors.lastname: Lee
authors.forename: Sung-Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Young Sam
authors.initials: YS
authors.lastname: Kim
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: In
authors.forename: Bock Hyun
authors.initials: BH
authors.lastname: Jung
authors.forename: Kwan Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Seung Won
authors.initials: SW
authors.lastname: Ra
authors.forename: Yong Il
authors.initials: YI
authors.lastname: Hwang
authors.forename: Yong-Bum
authors.initials: YB
authors.lastname: Park
authors.forename: Ki-Suck
authors.initials: KS
authors.lastname: Jung
mesh_terms: D000368:Aged; D003863:Depression / Q000453:epidemiology*; D003866:Depressive Disorder / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
keywords: COPD Assessment Test; Depression; Pulmonary Disease, Chronic Obstructive