title: Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis.
abstract: Published studies researching the prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with osteosarcoma are inconclusive and heterogeneous. We conducted a meta-analysis to assess its prognostic value more precisely. The pooled odds ratios (ORs) or hazard ratios (HRs) with corresponding 95 % confidence intervals (CIs) were calculated to evaluate the effects. Fourteen studies with 735 osteosarcoma patients were included to estimate the relationship between COX-2 and metastasis of tumor, clinical stage, and 3-year overall survival. High expressions of COX-2 predicted neoplasm metastasis (OR = 1.891, 95 % CI 1.276-2.803, P = 0.002), advanced clinical stage (OR = 1.801, 95 % CI 1.257-2.581, P = 0.001). In addition, high COX-2 expression tended to be associated with a poor 3-year survival (HR = 1.741, 95 % CI 0.762-3.979, P = 0.188), but the difference was not significant. Therefore, this meta-analysis demonstrated that high COX-2 expression might be an unfavorable prognostic effect in osteosarcoma.
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, 100044, Beijing, People's Republic of China.
authors.forename: Guangjun
authors.initials: G
authors.lastname: Jiao
authors.forename: Tingting
authors.initials: T
authors.lastname: Ren
authors.forename: Qunshan
authors.initials: Q
authors.lastname: Lu
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Sun
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Lou
authors.forename: Xianbo
authors.initials: X
authors.lastname: Peng
authors.forename: Weimin
authors.initials: W
authors.lastname: Liang
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
mesh_terms: D001859:Bone Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D009367:Neoplasm Staging; D016017:Odds Ratio; D012516:Osteosarcoma / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D011379:Prognosis
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human