title: Sodium chloride 0.9% versus Lactated Ringer in the management of severely dehydrated patients with choleriform diarrhoea.
abstract: BACKGROUND
  Although experience within Peru suggests clinical and physiological benefits of treating dehydration caused by diarrhoea with Lactated Ringer's solution (LR) over sodium chloride 0.9%, (NaCl) there is little documented scientific evidence supporting this view. It is important to clarify this issue and determine the best solution for use during epidemics.
  
  
  METHODS
  Forty patients suffering from dehydration due to choleriform diarrhoea were enrolled in the study. Twenty patients were treated using NaCl (Group A) and the other twenty with LR (Group B). After diuresis recovery was achieved, the patients were continued on a course of oral rehydration salts. Serum electrolytes, arterial pH, HCO3-, and pCO2 were measured at three stages: at admission, after diuresis recovery, and after 12 hours.
  
  
  RESULTS
  Acidosis was corrected more quickly with LR that NaCl. The hyperosmolality and hypernatremic states were corrected with both solutions.
  
  
  CONCLUSIONS
  LR use resulted in a better clinical response than NaCl, illustrated by more rapid physiological correction, showing that mixed metabolic acidosis was corrected more quickly and more appropriately with this treatment.
authors.affiliation: Nephrology Service, University Hospital, Cayetano Heredia Peruvian University, Lima, Perú. javier.cieza@upch.pe
authors.forename: Javier Antonio
authors.initials: JA
authors.lastname: Cieza
authors.forename: Juana
authors.initials: J
authors.lastname: Hinostroza
authors.forename: Julio Arturo
authors.initials: JA
authors.lastname: Huapaya
authors.forename: Cristian Paul
authors.initials: CP
authors.lastname: León
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D003681:Dehydration / Q000628:therapy*; D003967:Diarrhea / Q000150:complications*; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010568:Peru; D000077325:Ringer's Lactate; D012965:Sodium Chloride / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012965:Sodium Chloride