title: Mitophagy: mitofusin recruits a mitochondrial killer.
abstract: Parkin is a cytosolic ubiquitin ligase that translocates to damaged mitochondria and promotes their degradation. Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin translocation to damaged mitochondria.
authors.affiliation: University of Washington, Department of Genome Sciences, W.H. Foege Building S-443, Box 355065, 3720 15th Ave NE, Seattle, WA 98195-5065, USA. pallanck@u.washington.edu
authors.forename: Leo
authors.initials: L
authors.lastname: Pallanck
mesh_terms: D000818:Animals; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans; D008929:Mitochondria, Heart / Q000201:enzymology*; D032383:Myocytes, Cardiac / Q000201:enzymology*; D011494:Protein Kinases / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D044767:Ubiquitin-Protein Ligases; D011494:Protein Kinases; D020558:GTP Phosphohydrolases