title: Evaluation of peripheral matrix metalloproteinase-1 in Parkinson's disease: a case-control study.
abstract: BACKGROUND
  Several types of proteinases are implicated in extracellular matrix (ECM) degradation, but the major enzymes are considered to be matrix metalloproteinases (MMPs). Matrix metalloproteinase-1 (MMP-1) is a major proteinase of the MMP family. MMP-1 is critical for modeling and remodeling of the extracellular matrix. In the present study, we evaluated circulating level of MMP-1 in Parkinson's disease (PD) patients and controls.
  
  
  METHODS
  Enzyme linked immunosorbent assay (ELISA) was used to determine the serum level of MMP-1 in Parkinson's patients and matched healthy controls.
  
  
  RESULTS
  The mean age of Parkinson's patients (65%) and controls (62.5%) were 55.80 ± 9.69 and 54.05 ± 8.71 years respectively, with similar male/female ratio between patients and controls. The MMP-1 level was (p = 0.005) significantly lower in Parkinson's patients (2380.32 ± 2245.27 pg/ml) as compared to controls (4453.07 ± 3321.01 pg/ml). Poor correlation was found between MMP-1 level and disease duration (r = 0.36, p = 0.02), however it was statistically significant.
  
  
  CONCLUSIONS
  Significantly lower level of serum MMP-1 was found in PD patients in comparison to controls. This difference in MMP-1 level was more prominent in females.
authors.affiliation: 1Department of Pharmacology & Therapeutics, King George's Medical University , Lucknow, Uttar Pradesh , India.
authors.forename: Vineeta
authors.initials: V
authors.lastname: Gupta
authors.forename: Manish Kumar
authors.initials: MK
authors.lastname: Singh
authors.forename: Ravindra Kumar
authors.initials: RK
authors.lastname: Garg
authors.forename: Kamlesh Kumar
authors.initials: KK
authors.lastname: Pant
authors.forename: Sanjay
authors.initials: S
authors.lastname: Khattri
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000201:enzymology*; D012727:Sex Characteristics; D013997:Time Factors
chemical_list: D020781:Matrix Metalloproteinase 1