title: Axin: an emerging key scaffold at the synapse.
abstract: Neurons communicate through neurotransmission at the synapse. Precise regulation of the synaptic structure and signaling during the formation and remodeling of synapses is vital for information processing between neurons. Scaffold proteins play key roles in synapses by tethering the signaling cascades spatially and temporally to ensure proper brain functioning. This review summarizes the recent evidence indicating that Axin, a scaffold protein, plays a central role in orchestrating presynaptic and postsynaptic signaling complexes to regulate synapse development and plasticity in the central nervous system.
authors.affiliation: Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Amy K Y
authors.initials: AK
authors.lastname: Fu
authors.forename: Nancy Y
authors.initials: NY
authors.lastname: Ip
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D060466:Axin Protein / Q000502:physiology*; D000072261:Dishevelled Proteins; D017491:Genes, APC / Q000502:physiology; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010750:Phosphoproteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D060466:Axin Protein; D000072261:Dishevelled Proteins; D010750:Phosphoproteins; D051176:beta Catenin; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3
keywords: Cdk5; GSK-3; Wnt signaling; synaptic plasticity; β-catenin