title: C-erbB2/HER2 in human gliomas, medulloblastomas, and meningiomas: a minireview.
abstract: C-erbB2/HER2 serves as an important prognostic and predictive biomarker in various human tumors, especially in breast cancer, whereas its role in human intracranial tumors is more uncertain. We therefore performed a search in PubMed to get an update. This literature review comprises immunohistochemical studies on the clinical significance of c-erbB2/HER2 overexpression in gliomas, medulloblastomas, and meningiomas. In general, the findings were discrepant with regard to correlations between overexpression, tumor grade, and prognosis. Use of various antibodies may be a contributing factor to these discrepancies. Standardization of the immunohistochemical procedures is a relevant topic for discussion.
authors.affiliation: 1Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
authors.forename: Ingunn Syversen
authors.initials: IS
authors.lastname: Waage
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Vreim
authors.forename: Sverre Helge
authors.initials: SH
authors.lastname: Torp
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D005910:Glioma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008527:Medulloblastoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008579:Meningioma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases
keywords: NEU; astrocytomas; brain tumors; diagnosis; growth factor receptors; immunohistochemistry; prognosis; survival