title: Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials.
abstract: There is a great deal of interest in the development of nanoplatforms gathering versatility and multifunctionality. The strategy reported herein meets these requirements and further integrates a cell-friendly shell in a bio-inspired approach. By taking advantage of a cell mechanism of biomolecule transport using vesicles, we engineered a hybrid biogenic nanoplatform able to encapsulate a set of nanoparticles regardless of their chemistry or shape. As a proof of versatility, different types of hybrid nanovesicles were produced: magnetic, magnetic-metallic and magnetic-fluorescent vesicles, either a single component or multiple components, combining the advantageous properties of each integrant nanoparticle. These nanoparticle-loaded vesicles can be manipulated, monitored by MRI and/or fluorescence imaging methods, while acting as efficient nano-heaters. The resulting assets for targeting, imaging and therapy converge for the outline of a new generation of nanosystems merging versatility and multifunctionality into a bio-camouflaged and bio-inspired approach.
authors.affiliation: Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France. claire.wilhelm@univ-paris-diderot.fr.
authors.forename: Amanda K Andriola
authors.initials: AK
authors.lastname: Silva
authors.forename: Riccardo
authors.initials: R
authors.lastname: Di Corato
authors.forename: Teresa
authors.initials: T
authors.lastname: Pellegrino
authors.forename: Sophie
authors.initials: S
authors.lastname: Chat
authors.forename: Giammarino
authors.initials: G
authors.lastname: Pugliese
authors.forename: Nathalie
authors.initials: N
authors.lastname: Luciani
authors.forename: Florence
authors.initials: F
authors.lastname: Gazeau
authors.forename: Claire
authors.initials: C
authors.lastname: Wilhelm
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism; D005290:Ferric Compounds / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D013696:Temperature; D053835:Unilamellar Liposomes / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D005290:Ferric Compounds; D005456:Fluorescent Dyes; D053835:Unilamellar Liposomes; C000499:ferric oxide; D006046:Gold