title: A new quassinoid from fruits of Brucea javanica.
abstract: A new minor quassinoid named bruceine M (1), together with 12 known quassinoids (2-13), was isolated from the fruits of Brucea javanica (Simaroubaceae). Their structures were determined by interpretation of NMR and HR-ESI-MS data. The structures of the known compounds were confirmed by comparison of their spectral data with those reported in the literatures. In vitro cytotoxicity of the isolated compounds against cancer cell lines Bel-7404, MCF-7 and A549 was evaluated. Compounds 4, 6 and 9 exhibited significant growth inhibitory activity against three cancer cell lines.
authors.affiliation: a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , 510650 , People's Republic of China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Su
authors.forename: Jing
authors.initials: J
authors.lastname: Hao
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Xu
authors.forename: Riming
authors.initials: R
authors.lastname: Huang
authors.forename: Nenling
authors.initials: N
authors.lastname: Zhang
authors.forename: Shengxiang
authors.initials: S
authors.lastname: Qiu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D032269:Brucea / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D036702:Quassins / Q000737:chemistry* / Q000494:pharmacology; D029641:Simaroubaceae / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D036702:Quassins