title: Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation.
abstract: OBJECTIVE
  The objective of this study was to define the radiological characteristics of 2-phase computed tomography (CT) of parotid gland Warthin tumors (WTs) with a pathologic basis for these findings.
  
  
  METHODS
  We prospectively enrolled 116 patients with parotid gland tumor who underwent preoperative 2-phase CT scans(scanning delays of 30 and 120 seconds). The attenuation changes and enhancement patterns were analyzed according to pathology. We also evaluated size-matched samples of WTs and pleomorphic adenoma by staining CD31, vascular endothelial growth factor-receptor 2, collagen IV, and smooth muscle actin.
  
  
  RESULTS
  Computed tomography numbers in WTs were significantly higher than those in other tumors in early-phase scans and lower in delayed scans. Pathologically, CD31(+) blood vessel area was significantly higher in WTs than in pleomorphic adenomas. In addition, WTs had an extensive capillary network and many leaky blood vessels.
  
  
  CONCLUSIONS
  The enhancement pattern of early fill-in and early washout is the typical finding of WTs on 2-phase CT scans, which may be attributed pathologically to abundant blood vessel and extensive capillary network.
authors.affiliation: Department of Otolaryngology, Gyeongsang National University, Jinju, Korea.
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Woo
authors.forename: Dae-Seob
authors.initials: DS
authors.lastname: Choi
authors.forename: Jin-pyeong
authors.initials: JP
authors.lastname: Kim
authors.forename: Jung Je
authors.initials: JJ
authors.lastname: Park
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Joo
authors.forename: Phil-Sang
authors.initials: PS
authors.lastname: Chung
authors.forename: Bo-Young
authors.initials: BY
authors.lastname: Kim
authors.forename: Young-Hyeh
authors.initials: YH
authors.lastname: Ko
authors.forename: Han-Sin
authors.initials: HS
authors.lastname: Jeong
authors.forename: Hyung-Jin
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000235:Adenolymphoma / Q000145:classification / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D010307:Parotid Neoplasms / Q000145:classification / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*