title: High resolution (3 Tesla) MRI-guided conformal brachytherapy for cervical cancer: consequences of different high-risk CTV sizes.
abstract: OBJECTIVE
  To evaluate conventional brachytherapy (BT) plans using dose-volume parameters and high resolution (3 Tesla) MRI datasets, and to quantify dosimetric benefits and limitations when MRI-guided, conformal BT (MRIG-CBT) plans are generated.
  
  
  METHODS
  Fifty-five clinical high-dose-rate BT plans from 14 cervical cancer patients were retrospectively studied. All conventional plans were created using MRI with titanium tandem-and-ovoid applicator (T&O) for delivery. For each conventional plan, a MRIG-CBT plan was retrospectively generated using hybrid inverse optimization. Three categories of high risk (HR)-CTV were considered based on volume: non-bulky (< 20 cc), low-bulky (> 20 cc and < 40 cc) and bulky (≥ 40 cc). Dose-volume metrics of D90 of HR-CTV and D2cc and D0.1cc of rectum, bladder, and sigmoid colon were analyzed.
  
  
  RESULTS
  Tumor coverage (HR-CTV D90) of the conventional plans was considerably affected by the HR-CTV size. Sixteen percent of the plans covered HR-CTV D90 with the prescription dose within 5%. At least one OAR had D2cc values over the GEC-ESTRO recommended limits in 52.7% of the conventional plans. MRIG-CBT plans showed improved target coverage for HR-CTV D90 of 98 and 97% of the prescribed dose for non-bulky and low-bulky tumors, respectively. No MRIG-CBT plans surpassed the D2cc limits of any OAR. Only small improvements (D90 of 80%) were found for large targets (> 40 cc) when using T&O applicator approach.
  
  
  CONCLUSIONS
  MRIG-CBT plans displayed considerable improvement for tumor coverage and OAR sparing over conventional treatment. When the HR-CTV volume exceeded 40 cc, its improvements were diminished when using a conventional intracavitary applicator.
authors.affiliation: Radiation Oncology Department, Rush University, Chicago.
authors.forename: James W
authors.initials: JW
authors.lastname: Anderson
authors.forename: Junyi
authors.initials: J
authors.lastname: Xia
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Flynn
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Modrick
authors.forename: Sudershan K
authors.initials: SK
authors.lastname: Bhatia
authors.forename: Geraldine M
authors.initials: GM
authors.lastname: Jacobson
authors.forename: Yusung
authors.initials: Y
authors.lastname: Kim
keywords: MRI-guided brachytherapy; brachytherapy; cervical cancer; high-dose-rate brachytherapy