title: Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population.
abstract: OBJECTIVE
  To investigate the role of interleukin 6 (IL6) and IL16 single nucleotide polymorphisms (SNPs) in coronary artery disease (CAD) risk in a Chinese population.
  
  
  METHODS
  Patients with CAD and healthy control subjects were recruited. IL6 (rs1800795 and rs1800796) and IL16 (rs8034928, rs3848180, rs4577037, rs1131445, rs4778889 and rs11556218) genotyping was performed on the MassARRAY® platform (Sequenom®, San Diego, CA, USA).
  
  
  RESULTS
  Frequencies of rs8034928 variant C allele and rs11556218 variant T allele were higher in patients with CAD (n = 326) than controls (n = 341). The rs8034928 C/C genotype (odds ratio [OR] 2.03; 95% confidence intervals [CI] 1.16, 3.62) and C allele (OR 1.97; 95%CI 1.15, 3.45) were associated with increased risk of CAD compared with wild type. Similarly, the rs11556218 T/T genotype (OR 2.44; 95%CI 1.15, 5.44) and T allele (OR 2.37; 95%CI 1.13, 5.24) were associated with increased CAD risk compared with wild type.
  
  
  CONCLUSIONS
  The SNPs rs8034928 and rs11556218 are associated with CAD risk in the Chinese population, and may be useful predictive markers for CAD susceptibility.
authors.affiliation: Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors.forename: Zichuan
authors.initials: Z
authors.lastname: Tong
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Wei
authors.forename: Guobin
authors.initials: G
authors.lastname: Miao
authors.forename: Xinchun
authors.initials: X
authors.lastname: Yang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D019410:Interleukin-16; D015850:Interleukin-6
keywords: Coronary artery disease; IL16; IL6; interleukin 16; interleukin 6; polymorphism; predictive markers