title: Getting to the guts of the matter: the status and potential of 'omics' research of parasitic protists of the human gastrointestinal system.
abstract: Parasitic protists are a major cause of diarrhoeal illnesses in humans globally. Collectively, enteric pathogens exceed all other forms of infectious disease, in terms of their estimated global prevalence and socioeconomic impact. They have a disproportionately high impact on children in impoverished communities, leading to acute (diarrhoea, vomiting, dehydration and death) and chronic disease (malabsorption, malnutrition, physical and cognitive stunting and predisposition to chronic, non-communicable disease) consequences. However, historically, investment in research and disease control measures has been disproportionately poor, leading to their current classification as neglected pathogens. A sound understanding of their biology is essential in underpinning detection, treatment and control efforts. One major tool in rapidly improving our knowledge of these parasites is the use of biological systems, including 'omic' technologies. In recent years, these tools have shown significant success when applied to enteric protists. This review summarises much of this knowledge and highlights the significant remaining knowledge gaps. A major focus of the present review was to provide a perspective on a way forward to address these gaps using advanced biotechnologies.
authors.affiliation: Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: ajex@unimelb.edu.au.
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Jex
authors.forename: Anson V
authors.initials: AV
authors.lastname: Koehler
authors.forename: Brendan R
authors.initials: BR
authors.lastname: Ansell
authors.forename: Louise
authors.initials: L
authors.lastname: Baker
authors.forename: Harin
authors.initials: H
authors.lastname: Karunajeewa
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
mesh_terms: D003967:Diarrhea / Q000469:parasitology; D005767:Gastrointestinal Diseases / Q000469:parasitology*; D023281:Genomics; D006801:Humans; D010272:Parasitic Diseases / Q000469:parasitology*
keywords: Cryptosporidium; Diarrhoeal pathogens; Entamoeba; Genomics; Giardia; Systems biology