title: Atypical adenomatous hyperplasia of prostate lacks TMPRSS2-ERG gene fusion.
abstract: Atypical adenomatous hyperplasia (AAH) is a distinct entity in prostate pathology, defined as a well-circumscribed lobule of closely packed crowded small glands or acini. Although it has been proposed as a precursor lesion to prostate cancer, the biological nature of AAH is currently uncertain. The TMPRSS2-ERG fusion gene is a common recurrent chromosomal rearrangement in prostate cancer and in its precursor lesion, prostatic intraepithelial neoplasia. The prevalence of TMPRSS2-ERG alteration in AAH is unknown. Fifty-five separate prostate specimens containing AAH were investigated by fluorescence in situ hybridization and immunohistochemistry for TMPRSS2-ERG rearrangement. TMPRSS2-ERG rearrangements were not identified in AAH either by fluorescence in situ hybridization or by immunohistochemistry.
authors.affiliation: Departments of *Pathology †Urology, Indiana University School of Medicine, Indianapolis, IN ‡Department of Pathology, Case Western Reserve University, Cleveland, OH §Department of Pathology, Cordoba University, Cordoba, Spain ∥Department of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region (Ancona), Ancona, Italy ¶Department of Pathology, Singapore General Hospital, Singapore.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Darrell D
authors.initials: DD
authors.lastname: Davidson
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Maclennan
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.forename: Mingsheng
authors.initials: M
authors.lastname: Wang
authors.forename: Puay-Hoon
authors.initials: PH
authors.lastname: Tan
authors.forename: Lee Ann
authors.initials: LA
authors.lastname: Baldridge
authors.forename: Shaobo
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics*; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000473:pathology
chemical_list: D015514:Oncogene Proteins, Fusion; C515553:TMPRSS2-ERG fusion protein, human