title: [Effect of vascular endothelial growth factor C and collagen triple helix repeat containing 1 expression on prognosis of rectal carcinoma patients].
abstract: OBJECTIVE
  To explore the relationship of vascular endothelial growth factor C (VEGF-C) and collagen triple helix repeat containing 1 (CTHRC1) expression with the carcinogenesis and prognosis of rectal cancer.
  
  
  METHODS
  Cancer tissue samples from 120 rectal cancer patients confirmed by pathology in the People's Hospital of Yichun City from September 2005 to September 2010 were included in the study. Expressions of CTHRC1 and VEGF-C were examined by immunohistochemistry and their correlations with clinicopathological features and prognosis were analyzed.
  
  
  RESULTS
  The expression of VEGF-C was positively correlated with tumor size (r=0.943), TNM stages (r=0.784) and tumor differentiation (r=0.773) (all P<0.05). Similarly, the expression of CTRHC1 was also positively correlated with tumor size (r=0.829), TNM stages (r=0.632) and tumor differentiation (r=0.532) (all P<0.05). Rectal cancer patients with low expression of VEGF-C and CTHRC1 had significantly longer survival than those with high expression of VEGF-C and CTHRC1 [(40.0±1.3) vs. (35.4±0.5) months, P<0.01, (39.0±0.5) vs. (35.0±0.5) months, P=0.014].
  
  
  CONCLUSIONS
  VEGF-C and CTHRC1 may synergistically promote the invasion and metastasis of human rectal cancer, and provide evidence in predicting the prognosis of patients.
authors.affiliation: Yichun university Clinic Medicine School, Jiangxi Yichun, China.
authors.forename: Wei-hua
authors.initials: WH
authors.lastname: Yin
authors.forename: Hui-zhen
authors.initials: HZ
authors.lastname: Fan
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Sheng
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Xia
authors.forename: Yu-wen
authors.initials: YW
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*; D055815:Young Adult
chemical_list: C502426:CTHRC1 protein, human; D016326:Extracellular Matrix Proteins; D042582:Vascular Endothelial Growth Factor C