title: Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes.
abstract: OBJECTIVE
  Some studies have reported associations between intracranial atherosclerosis and Alzheimer disease pathology. We aimed to correlate severity of cerebral atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy with neurofibrillary tangles, neuritic plaques, and cerebral infarcts.
  
  
  METHODS
  This autopsy study (n=163) was drawn from a longitudinal study of subcortical ischemic vascular disease, Alzheimer disease, and normal aging. Multivariable logistic regression models were used to test associations among the 3 forms of cerebrovascular disease and the presence of ischemic and neurodegenerative brain lesions. Apolipoprotein E genotype was included as a covariate in these multivariable models.
  
  
  RESULTS
  Cerebral atherosclerosis was positively associated with microinfarcts (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.2-4.4) and cystic infarcts (OR, 2.0; 95% CI, 1.0-4.2) but not Alzheimer disease pathology. Arteriolosclerosis showed a positive correlation with lacunar infarcts (OR, 2.0; 95% CI, 1.0-4.2) but not Alzheimer disease pathology. Cerebral amyloid angiopathy was inversely associated with lacunar infarcts (OR, 0.6; 95% CI, 0.41-1.1), but positively associated with Braak and Braak stage (OR, 1.5; 95% CI, 1.1-2.1) and Consortium to Establish a Registry for Alzheimer Disease plaque score (OR, 1.5; 95% CI, 1.1-2.2).
  
  
  CONCLUSIONS
  Microinfarcts, which have been correlated with severity of cognitive impairment, were most strongly associated with atherosclerosis. Possible pathogenetic mechanisms include artery-to-artery emboli, especially microemboli that may include atheroemboli or platelet-fibrin emboli. Arteriolosclerosis was positively, whereas cerebral amyloid angiopathy was negatively correlated with lacunar infarcts, which might prove helpful in clinical differentiation of arteriolosclerotic from cerebral amyloid angiopathy-related vascular brain injury.
authors.affiliation: From the Department of Neurology (L.Z., C.Z., H.C.C.), and Department of Preventive Medicine (W.J.M.), Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Neurology, University of California Los Angeles, Los Angeles, CA (H.V.V.); and Department of Neurology, University of California Davis, Sacramento, CA (W.G.E.).
authors.forename: Ling
authors.initials: L
authors.lastname: Zheng
authors.forename: Harry V
authors.initials: HV
authors.lastname: Vinters
authors.forename: Wendy J
authors.initials: WJ
authors.lastname: Mack
authors.forename: Chris
authors.initials: C
authors.lastname: Zarow
authors.forename: William G
authors.initials: WG
authors.lastname: Ellis
authors.forename: Helena C
authors.initials: HC
authors.lastname: Chui
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D001057:Apolipoproteins E / Q000235:genetics; D020520:Brain Infarction / Q000209:etiology / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D012042:Registries; D059409:Stroke, Lacunar / Q000209:etiology / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology
chemical_list: D001057:Apolipoproteins E
keywords: Alzheimer; atherosclerosis; infarction; microinfarct