title: [The development of co-amorphous drug systems].
abstract: Converting two poorly water-soluble crystalline drugs to co-amorphous drug systems by ball milling, quench-cooling, or cryo-milling method can improve stability of the drug, enhance dissolution rates, and reduce adverse reactions of the single drug. Co-amorphous system has been used to solve problems of co-administration of medicines. Formation and intermolecular interactions of co-amorphous drug systems may be verified by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Raman spectroscopy (RS) and Fourier transform infrared spectroscopy (FT-IR). Stability of co-amorphous drug systems is influenced by their glass transition temperature (Tg) and intermolecular interactions. The theoretical Tg values and the interaction parameter x are calculated by Gordon-Taylor equation and the Flory-Huggins equation, respectively. Thus, co-amorphous drug systems are analyzed theoretically at molecular level. Co-amorphous drug systems provide a new sight for the co-administration of medicines.
authors.affiliation: Pharmaceutical College of Henan University, Kaifeng 475001, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yao
authors.forename: Nian-Qiu
authors.initials: NQ
authors.lastname: Shi
authors.forename: Xing-Lin
authors.initials: XL
authors.lastname: Wang
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002927:Cimetidine / Q000737:chemistry; D004338:Drug Combinations; D004339:Drug Compounding; D004355:Drug Stability; D005913:Glipizide / Q000737:chemistry; D007213:Indomethacin / Q000737:chemistry; D009288:Naproxen / Q000737:chemistry; D011899:Ranitidine / Q000737:chemistry; D019821:Simvastatin / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D004338:Drug Combinations; D009288:Naproxen; D002927:Cimetidine; D011899:Ranitidine; D019821:Simvastatin; D005913:Glipizide; D007213:Indomethacin