title: Impaired quality of life, disability and mental health in Takayasu's arteritis.
abstract: OBJECTIVE
  Patient-reported outcomes (PROs) are increasingly accepted to be among the major tools for outcome assessment in rheumatic disorders. In this study we aimed to assess quality of life (QoL), disability, anxiety and depression in patients with Takayasu's arteritis (TAK).
  
  
  METHODS
  Patients followed with the diagnosis of TAK (n = 165) and healthy controls (HCs) (n = 109) were enrolled to the study. The 36-item Short Form Health Survey (SF-36) and hospital anxiety and depression scales (HADS) were used to assess QoL and mental status together with HAQ for disability.
  
  
  RESULTS
  In SF-36 subscale assessment, all items were observed to be statistically lower in TAK patients; similarly HAQ scores were also higher (P < 0.001) in this group. In mental assessment, anxiety was found to be more common in TAK patients [90 (54.5%) vs 38 (34.9%), P = 0.001]. Depression also tended to be higher in TAK patients [70 (66.7%) vs 35 (33.3%)], without reaching significance (P = 0.086). Most of the SF-36 subgroup parameters were lower in TAK patients with active disease. Patients having anxiety and depression or with high HAQ scores reported worse SF-36 scores. In multivariate analysis, HADS-A, HADS-D and HAQ were associated with most SF-36 subscales.
  
  
  CONCLUSIONS
  PROs demonstrate that not only general health but also physical and social functioning with physical role limitations and mental health parameters were impaired in TAK. Our results, especially in active disease, suggest that PROs such as SF-36 can be core domains of disease assessment in TAK, similar to ANCA-associated vasculitides.
authors.affiliation: Arpaemini Cad. Tatlıpınar Cad., No: 6/2 - 34270, Fatih/Istanbul, Turkey. dr.yilmazneslihan@gmail.com.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Meryem
authors.initials: M
authors.lastname: Can
authors.forename: Fatma Alibaz
authors.initials: FA
authors.lastname: Oner
authors.forename: Melike
authors.initials: M
authors.lastname: Kalfa
authors.forename: Hakan
authors.initials: H
authors.lastname: Emmungil
authors.forename: Omer
authors.initials: O
authors.lastname: Karadag
authors.forename: Fatih
authors.initials: F
authors.lastname: Yildiz
authors.forename: Gezmis
authors.initials: G
authors.lastname: Kimyon
authors.forename: Baris
authors.initials: B
authors.lastname: Yilmazer
authors.forename: Vedat
authors.initials: V
authors.lastname: Gerdan
authors.forename: Sule Yasar
authors.initials: SY
authors.lastname: Bilge
authors.forename: Birkan
authors.initials: B
authors.lastname: Ilhan
authors.forename: Veli
authors.initials: V
authors.lastname: Cobankara
authors.forename: Timucin
authors.initials: T
authors.lastname: Kasifoglu
authors.forename: Ayse
authors.initials: A
authors.lastname: Cefle
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Kisacik
authors.forename: Ahmet Mesut
authors.initials: AM
authors.lastname: Onat
authors.forename: Servet
authors.initials: S
authors.lastname: Akar
authors.forename: Fatos
authors.initials: F
authors.lastname: Onen
authors.forename: Eren
authors.initials: E
authors.lastname: Erken
authors.forename: Sedat
authors.initials: S
authors.lastname: Kiraz
authors.forename: Kenan
authors.initials: K
authors.lastname: Aksu
authors.forename: Gokhan
authors.initials: G
authors.lastname: Keser
authors.forename: Gonca
authors.initials: G
authors.lastname: Mumcu
authors.forename: Haner
authors.initials: H
authors.lastname: Direskeneli
mesh_terms: D000328:Adult; D001007:Anxiety / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology / Q000209:etiology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011788:Quality of Life; D013625:Takayasu Arteritis / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology* / Q000534:rehabilitation; D014421:Turkey / Q000453:epidemiology
keywords: Takayasu’s arteritis; function; mental status; quality of life