title: Nickel-catalyzed Suzuki-Miyaura couplings in green solvents.
abstract: The nickel-catalyzed Suzuki-Miyaura coupling of aryl halides and phenol-derived substrates with aryl boronic acids using green solvents, such as 2-Me-THF and tert-amyl alcohol, is reported. This methodology employs the commercially available and air-stable precatalyst, NiCl2(PCy3)2, and gives biaryl products in synthetically useful to excellent yields. Using this protocol, bis(heterocyclic) frameworks can be assembled efficiently.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095-1569, USA.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Ramgren
authors.forename: Liana
authors.initials: L
authors.lastname: Hie
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Ye
authors.forename: Neil K
authors.initials: NK
authors.lastname: Garg
mesh_terms: D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D000439:Pentanols / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: C587233:2-me-tetrahydrofuran; D005663:Furans; D006219:Halogens; D006571:Heterocyclic Compounds; D000439:Pentanols; D010636:Phenols; D012997:Solvents; C032765:tert-amyl alcohol; D009532:Nickel