title: Survival, classifications, and desmosomal plaque genes in non-small cell lung cancer.
abstract: Novel biomarkers are required to improve prognostic predictions obtained with lung cancer staging systems. This study of 62 surgically-treated Non-Small Cell Lung Cancer (NSCLC) patients had two objectives: i) to compare the predictive value of T-stage classifications between the 6(th) and 7(th) editions of the Tumor, Node, and Metastasis staging system (TNM); and ii) to examine the association of Pkp1 and/or Krt15 gene expression with survival and outcomes. Multivariate and Kaplan-Meier survival analyses were performed, examining the relationship of survival with T-stage, recurrence, and TNM-stage (by each TNM edition) and with the single/combined expression of Pkp1 and/or Krt15 genes. Five-year survival rates only significantly differed as a function of T-stage in patients without recurrence when estimated using the 6(th) edition of the TNM classification and only in patients in pathologic TNM-stage IA using the 7(th). Overall survival for patients with elevated expression of both genes was 13.5 months in those with adenocarcinoma and 34.6 months in those with squamous cell carcinoma. Overall survival was 30.4 months in patients with Pkp1 gene upregulation and 30.9 months in those with Krt15 gene upregulation. In conclusion, survival estimations as a function of T-staging differed between the 6(th) and 7(th) editions of TNM. Overall survival differed according to the expression of Pkp1 and/or Krt15 genes, although this relationship did not reach statistical significance.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Granada School of Medicine, Granada, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Boyero
authors.forename: Abel
authors.initials: A
authors.lastname: Sánchez-Palencia
authors.forename: Ma Teresa
authors.initials: MT
authors.lastname: Miranda-León
authors.forename: Fernando
authors.initials: F
authors.lastname: Hernández-Escobar
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Gómez-Capilla
authors.forename: Ma Esther
authors.initials: ME
authors.lastname: Fárez-Vidal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000401:mortality; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D053208:Kaplan-Meier Estimate; D053569:Keratin-15 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D051191:Plakophilins / Q000378:metabolism
chemical_list: C116015:KRT15 protein, human; D053569:Keratin-15; C495335:PKP1 protein, human; D051191:Plakophilins
keywords: Survival; adenocarcinoma; desmosomal plaque; non-small cell lung cancer; squamous cell-carcinoma