title: A new protopanaxadiol-type ginsenoside from the roots of Panax notoginseng.
abstract: A new protopanaxadiol-type ginsenoside, 6-O-β-d-glucopyranosyl-20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-3-one (1), along with three known compounds, was isolated from the roots of Panax notoginseng. Their structures were determined based on some pieces of spectroscopic and chemical evidence. Compound 1 exhibited cytotoxic activity against five human cancer cell lines, with IC50 values ranging from 5.4 to 8.6 μg/ml.
authors.affiliation: a Jiangxi Provincial Institute for Drug and Food Control , Nanchang , 330029 , China.
authors.forename: Hui-Zheng
authors.initials: HZ
authors.lastname: Fu
authors.forename: Rui-Jian
authors.initials: RJ
authors.lastname: Zhong
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D036145:Ginsenosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D053723:Panax notoginseng / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D012502:Sapogenins / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D012502:Sapogenins; C585881:6-O-beta-D-glucopyranosyl-20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol-3-one; C112772:ginsenoside compound K; C062916:protopanaxadiol