title: Reduction of facial redness with resveratrol added to topical product containing green tea polyphenols and caffeine.
abstract: OBJECTIVE
  Many topical formulations include antioxidants to improve the antioxidant capability of the skin. This study evaluated the ability of a unique combination of antioxidants including resveratrol, green tea polyphenols, and caffeine to reduce facial redness.
  
  
  METHODS
  Subjects (n=16) presenting with facial redness applied the resveratrol-enriched product twice daily to the entire face. Reduction in redness was evaluated by trained staff members and dermatology house staff officers. Evaluators compared clinical photographs and spectrally enhanced images taken before treatment and at 2-week intervals for up to 12 weeks.
  
  
  RESULTS
  16 of 16 clinical images showed improvement and 13 of 16 spectrally enhanced images were improved. Reduction in facial redness continued to evolve over the duration of the study period but was generally detectable by 6 weeks of treatment. Adverse effects were not observed in any subject.
  
  
  CONCLUSIONS
  The skin product combination of resveratrol, green tea polyphenols, and caffeine safely reduces facial redness in most patients by 6 weeks of continuous treatment and may provide further improvement with additional treatment.
authors.affiliation: State University of New York Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Georgina
authors.initials: G
authors.lastname: Ferzli
authors.forename: Mital
authors.initials: M
authors.lastname: Patel
authors.forename: Natasha
authors.initials: N
authors.lastname: Phrsai
authors.forename: Neil
authors.initials: N
authors.lastname: Brody
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000627:therapeutic use; D002110:Caffeine / Q000008:administration & dosage / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004338:Drug Combinations; D005148:Facial Dermatoses / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D059808:Polyphenols / Q000008:administration & dosage / Q000627:therapeutic use; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000627:therapeutic use; D013662:Tea / Q000737:chemistry; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D003879:Dermatologic Agents; D004338:Drug Combinations; D059808:Polyphenols; D013267:Stilbenes; D013662:Tea; D002110:Caffeine; D000077185:Resveratrol