title: The impact of hyperglycemia on risk of infection and early death during induction therapy for acute lymphoblastic leukemia (ALL).
abstract: Hyperglycemia during induction chemotherapy for childhood acute lymphoblastic leukemia (ALL) has been inconsistently associated with risk of infection. We investigated the incidence of hyperglycemia during induction for childhood ALL in a retrospective cohort study of 144 patients treated on a single national protocol (UKALL2003) and explored its association with infection. All patients received dexamethasone. Overt hyperglycemia was seen in 36% and proven bacterial or fungal infection was most common in this group (OR 4.1 (1.1-15.6), P = 0.039). Both hyperglycaemia and infection were particularly common in patients with Down Syndrome.
authors.affiliation: Department of Haematology Oncology, Bristol Royal Hospital for Children, Bristol, United Kingdom.
authors.forename: Julianne M
authors.initials: JM
authors.lastname: Dare
authors.forename: John P
authors.initials: JP
authors.lastname: Moppett
authors.forename: Julian Ph
authors.initials: JP
authors.lastname: Shield
authors.forename: Linda P
authors.initials: LP
authors.lastname: Hunt
authors.forename: Michael Cg
authors.initials: MC
authors.lastname: Stevens
mesh_terms: D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology / Q000209:etiology*; D015994:Incidence; D060828:Induction Chemotherapy / Q000009:adverse effects*; D008297:Male; D009181:Mycoses / Q000453:epidemiology / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012307:Risk Factors
keywords: children; hyperglycemia; infection; leukemia