title: Pyloric atresia: A report of ten patients.
abstract: Pyloric atresia (PA) is uncommon. It occurs in 1:100000 live births. Neonates usually present soon after birth with copious non-bilious vomiting. The treatment is surgical and its prognosis is poor, especially, when it is associated with epidermolysis bullosa (EB). The aim of this study was to evaluate the clinical presentation, diagnosis, operative management, post-operative courses, and outcome in infant with PA, based in our cases and literature review. Charts of 10 patients who underwent surgery for PA in the department of paediatric surgery in a Teaching Hospital in Tunisia (Monastir) between 1990 and 2012 were reviewed. Data were analysed for demographic, clinical, therapeutic, and prognostic characteristics. The average of age at presentation was 2 days and there were six males and four females. The main presenting symptoms were non-bilious vomiting in 90% of cases. Abdominal X-ray showed gastric dilatation with an absence of gas in the rest of the intestinal tract in 90%, and a pneumoperitoneum in one. The surgical approach was laparotomy in all cases. Gastric perforation was observed in one patient and was completely repaired. The distribution of the anatomic variations was type A in nine cases and type B in one. Five patients underwent excision of the diaphragm and Heineke-Mikulicz pyloroplasty and gastroduodenostomy in the other five cases. Identified associated anomalies were Down's syndrome in one and EB in 2 (20%), one family has three affected sibling. Post-operative mortality rate was 70%. No standard surgical approach can be adopted a better management of PA or the associated anomalies depends on an early diagnosis and the availability of neonatal intensive care unit.
authors.affiliation: Department of Pediatric Surgery, Hospital Fattouma Bourguiba Monastir, Medical School of Monastir, Tunisia. amineks@yahoo.fr
authors.forename: Amine
authors.initials: A
authors.lastname: Ksia
authors.forename: Hayett
authors.initials: H
authors.lastname: Zitouni
authors.forename: Ahmad
authors.initials: A
authors.lastname: Zrig
authors.forename: Rachida
authors.initials: R
authors.lastname: Laamiri
authors.forename: Fatma
authors.initials: F
authors.lastname: Chioukh
authors.forename: Eya
authors.initials: E
authors.lastname: Ayari
authors.forename: Lassaad
authors.initials: L
authors.lastname: Sahnoun
authors.forename: Kais
authors.initials: K
authors.lastname: Maazoun
authors.forename: Imed
authors.initials: I
authors.lastname: Krichene
authors.forename: Mongi
authors.initials: M
authors.lastname: Mekki
authors.forename: Mohsen
authors.initials: M
authors.lastname: Belghith
authors.forename: Abdellatif
authors.initials: A
authors.lastname: Nouri
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D017219:Gastric Outlet Obstruction / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007813:Laparotomy / Q000379:methods*; D008297:Male; D011708:Pylorus / Q000002:abnormalities* / Q000601:surgery; D011860:Radiography, Abdominal; D012189:Retrospective Studies