title: Quality of life in Malaysian colorectal cancer patients.
abstract: BACKGROUND
  The rapidly increasing of incidence colorectal cancer (CRC) in Malaysia and the introduction of new treatments that prolong survival advocating treatment outcome measures such as patients' quality of life (QOL) are evaluated in this study. The study aims to determine QOL in CRC patients according to cancer stage and age.
  
  
  METHODS
  A cross-sectional study was performed from June to December 2011 at four public tertiary hospitals. The European Organization for Research and Treatment in Cancer (EORTC) Quality of Life Questionnaire Core-30 (EORTC QLQ C-30) questionnaire was used through face-to-face interview and the medical records of 160 respondents were reviewed.
  
  
  RESULTS
  The mean age of respondents was 58.47 ± 12.04 years with 57.5% of respondents being male and 42.5% female. The majority of respondents were in CRC stages III and IV. Median global health status (GHS) score was 83.33 (IQR 16.67). Sikhs and Indians had a higher median GHS score compared to other ethnicities (Kruskal-Wallis, χ(2)  = 12.12, p = 0.007). Emotional, cognitive and social functions were higher in respondents with earlier stage of disease (Kruskal-Wallis, χ2 = 6.06, 6.36, 10.58, p = 0.048, 0.042, 0.005). Median pain, dyspnea, diarrhea and financial implication scores were significantly higher in advanced stage of disease (Kruskal-Wallis, χ(2)  = 9.31, 6.26,6.77, 7.28, p = 0.010, 0.044,0.034,0.026). Median diarrhea score (p = 0.012) was significantly different between age groups.
  
  
  CONCLUSIONS
  Emotional, cognitive and social functions deteriorate with advanced stage of disease. Patients with advanced stage disease experience more pain, dyspnea, diarrhea and financial implications. A systematic screening program to detect cases as early as possible is essential nationwide.
authors.affiliation: Department of Community Health, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia. sh_ezat@yahoo.com
authors.forename: Sharifa Ezat
authors.initials: SE
authors.lastname: Wan Puteh
authors.forename: Natrah Mohd
authors.initials: NM
authors.lastname: Saad
authors.forename: Syed Mohd
authors.initials: SM
authors.lastname: Aljunid
authors.forename: Mohd Rizal
authors.initials: MR
authors.lastname: Abdul Manaf
authors.forename: Saperi
authors.initials: S
authors.lastname: Sulong
authors.forename: Ismail
authors.initials: I
authors.lastname: Sagap
authors.forename: Fuad
authors.initials: F
authors.lastname: Ismail
authors.forename: Muhd Azrif
authors.initials: MA
authors.lastname: Muhammad Annuar
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D007407:Interviews as Topic; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: EORTC QLQ C-30; colorectal cancer; quality of life