title: The role of diet in triggering human inflammatory disorders in the modern age.
abstract: Previously uncommon human inflammatory disorders are emerging with alarming frequency, possibly triggered by environmental factors introduced through Westernization. This review highlights how Western diets heighten the inflammatory state promoting development of disease. Evidence that this can occur directly or indirectly through perturbations of host-microbe interactions are reviewed.
authors.affiliation: Department of Medicine, University of Chicago, 900 East 57th Street, Chicago, IL 60637, USA. Electronic address: eyhuang@uchicago.edu.
authors.forename: Edmond Y
authors.initials: EY
authors.lastname: Huang
authors.forename: Suzanne
authors.initials: S
authors.lastname: Devkota
authors.forename: Dagmara
authors.initials: D
authors.lastname: Moscoso
authors.forename: Eugene B
authors.initials: EB
authors.lastname: Chang
authors.forename: Vanessa A
authors.initials: VA
authors.lastname: Leone
mesh_terms: D001172:Arthritis, Rheumatoid / Q000453:epidemiology*; D004032:Diet / Q000009:adverse effects*; D054884:Host-Pathogen Interactions; D006801:Humans; D007109:Immunity; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology*; D024821:Metabolic Syndrome / Q000453:epidemiology*
keywords: Gut microbiota; High-fat; Immunity; Inflammatory disease; Systemic inflammation; Western diet