title: Medical ozone therapy for the inner ear acoustic trauma.
abstract: OBJECTIVE
  The goal of the study was to look at the potential protective effect of ozone therapy by studying its antioxidant and vasodilatation effects against hearing loss caused by acoustic trauma.
  
  
  METHODS
  Thirty-two male Wistar Albino rats were divided into four groups of eight. The 1st group was exposed to acoustic trauma, the 2nd group was treated with ozone initially, and was exposed to acoustic trauma 24 h later, the 3rd group received ozone without trauma, while the 4th group was the control group. The 1st and 2nd groups were exposed to acoustic trauma with 105 dB SPL white band noise for 4h. DPOAE and ABR tests were conducted in all groups on the 1st, 5th, and 10th days after trauma.
  
  
  RESULTS
  In the 1st group, the effects of acoustic trauma continued on days 1, 5 and 10. The 2nd group's DPOAE and ABR results on days 5 and 10 showed significant improvement at all frequencies compared to deterioration on day 1, and the readings were comparable to baseline measurements.
  
  
  CONCLUSIONS
  Acoustic trauma is a pathology that is experienced frequently and leads to many problems in terms of health and cost. Ozone was demonstrated to be a reparative substance against acoustic trauma and, in addition, it can be supplied and applied easily.
authors.affiliation: Karaman State Hospital, Otorhinolaryngology Clinic, Karaman, Turkey. alperyenigun@gmail.com
authors.forename: Alper
authors.initials: A
authors.lastname: Yenigun
authors.forename: Fadlullah
authors.initials: F
authors.lastname: Aksoy
authors.forename: Remzi
authors.initials: R
authors.lastname: Dogan
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Yilmaz
authors.forename: Bayram
authors.initials: B
authors.lastname: Veyseller
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozturan
authors.forename: Burak
authors.initials: B
authors.lastname: Ozturk
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D004195:Disease Models, Animal; D007758:Ear, Inner / Q000187:drug effects* / Q000293:injuries; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy*; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D038781:Otoscopy / Q000379:methods; D010126:Ozone / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D010126:Ozone
keywords: Acoustic trauma; Auditory brainstem response; Inner ear; Otoacoustic emission; Ozone therapy