title: Antitumor efficacy of paclitaxel-loaded polylactide/ poly(ethylene glycol) nanoparticles combination with exercise in tumor-bearing mice.
abstract: The nanoparticles (NPs) provide a promising prospect for tumor therapy, and exercise is also becoming readily and accepted as a beneficial adjunct therapy to maintain or enhance quality of life in cancer patients. We investigate the antitumor efficacy of paclitaxel (PT) loaded polylactide/poly(ethylene glycol) NPs (PT-PLA/PEG NPs) under the exercise conditions. Results showed that within the first 7 days, the PT concentration in tumor maintained at a higher level in the PT-PLA/PEG NPs + exercise (PT-PLA/PEG NPs + EX) group as compared with the PT-PLA/PEG NPs group. All the phagocytosis rates of macrophages were significantly decreased below the CON in exercise group. The most significant antitumor effect was observed in PT-PLA/PEG NPs + EX group, demonstrating that the PT-PLA/PEG NPs improved the concentration of PT, and exercise could further increased its therapeutic efficiency for tumor. These researches may provide an effective means for tumor therapy.
authors.affiliation: Physical Education College, Yangzhou University, Yangzhou 225009, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Ma
authors.forename: Peifeng
authors.initials: P
authors.lastname: Liu
authors.forename: Qin
authors.initials: Q
authors.lastname: Ji
authors.forename: Jie
authors.initials: J
authors.lastname: Qi
authors.forename: Yourong
authors.initials: Y
authors.lastname: Duan
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism*; D051379:Mice; D053758:Nanoparticles; D017239:Paclitaxel / Q000008:administration & dosage / Q000494:pharmacology*; D010805:Physical Conditioning, Animal; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011091:Polyesters; D011092:Polyethylene Glycols; C033616:poly(lactide); D017239:Paclitaxel