title: Potential role of branched-chain amino acid catabolism in regulating fat oxidation.
abstract: Insulin-resistant or obese individuals have increased serum branched-chain amino acid (BCAA) levels. Recent findings relate increased BCAA catabolism to increased fatty acid oxidation and better metabolic health in physically active individuals. We hypothesize that, via glyceroneogenesis, BCAA catabolism mediates increased constitutive use of fatty acids for β-oxidation in subjects with increased inherent or acquired aerobic capacity both during exercise and at rest.
authors.affiliation: 1Departments of Biology of Physical Activity, and 2Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
authors.forename: Heikki
authors.initials: H
authors.lastname: Kainulainen
authors.forename: Juha J
authors.initials: JJ
authors.lastname: Hulmi
authors.forename: Urho M
authors.initials: UM
authors.lastname: Kujala
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000597:Amino Acids, Branched-Chain / Q000097:blood / Q000378:metabolism*; D000818:Animals; D015444:Exercise / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D000597:Amino Acids, Branched-Chain