title: Evaluation of an oxygen-diffusion dressing for accelerated healing of donor-site wounds.
abstract: Accelerating the healing process and reducing pain during healing are beneficial for the following reasons: faster return to work, lower risk of wound infection, improved quality of life, and possibly reduced need for analgesia. This clinical study assessed the effectiveness of a new oxygen-diffusion dressing (OxyBand; Oxyband Technologies, St. Louis, MO) compared with standard Xeroform gauze dressings (Convidien, Mansfield, MA), in the care of skin-graft donor sites in burn patients. Time to healing was the primary endpoint, and pain scores and cosmetic outcome were also assessed. This was a prospective, randomized, controlled study of burn patients undergoing harvesting of two donor sites. Patients were followed at predetermined time points for 30 to 45 days to determine the time to reepithelialization, cosmetic appearance, and pain. Subjects were adult burn patients with less than 30% TBSA burns admitted to the burn center, who required excision and grafting. Twenty patients were enrolled, of whom 17 completed the study. Average age was 35 years. Average burn size was 9.2% TBSA. Patients underwent harvesting of split-thickness skin grafts with one donor wound dressed with OxyBand and the other dressed in Xeroform gauze. Wounds were inspected and photographed on postoperative days 4 and 8, and then every 2 days until the donor wounds were healed. Pain scores at each site were also collected at these visits (rated by patients on a scale from 0 to 10). Mean time to wound healing for OxyBand was 9.3 ± 1.7 days; for Xeroform, 12.4 ± 2.7 days (P < .001). Pain scores were lower (P < .01) at the OxyBand site compared with the Xeroform site at all time points during postoperative days 4 to 12. There was no difference in the cosmetic outcome of the wounds at 30 to 45 days postoperatively. This study revealed a decrease in the time to healing and in pain at donor sites dressed with an oxygen-diffusion dressing.
authors.affiliation: From the U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas.
authors.forename: Kimberly F
authors.initials: KF
authors.lastname: Lairet
authors.forename: David
authors.initials: D
authors.lastname: Baer
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Leas
authors.forename: Evan M
authors.initials: EM
authors.lastname: Renz
authors.forename: Leopoldo C
authors.initials: LC
authors.lastname: Cancio
mesh_terms: D000328:Adult; D001458:Bandages; D002056:Burns / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006772:Hospitals, Military; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000627:therapeutic use*; D010147:Pain Measurement; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D016038:Skin Transplantation / Q000009:adverse effects / Q000379:methods*; D013997:Time Factors; D060053:Transplant Donor Site / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*; D014946:Wound Infection / Q000517:prevention & control; D055815:Young Adult
chemical_list: D010100:Oxygen