title: [Involvement of Akt in regulation of skeletal muscle metabolism].
abstract: The enzyme Akt 1 is a member of serine/threonine specific protein kinases family. Akt plays an important role in the transmission of extracellular signals and mechanical stimuli via phosphorylation of its numerous substrates involved in anabolic and catabolic processes as well as mechanical responses of skeletal muscle. Expression of the Akt is increased during skeletal muscle hypertrophy and decreased during muscle atrophy. The G205T polymorphism of Akt is associated with transcriptional activity of the gene in muscle cells and, respectively, with skeletal muscle phenotypes.
authors.forename: A M
authors.initials: AM
authors.lastname: Druzhevskaia
authors.forename: I I
authors.initials: II
authors.lastname: Akhmetov
authors.forename: V A
authors.initials: VA
authors.lastname: Rogozkin
mesh_terms: D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism*; D009133:Muscular Atrophy / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D051057:Proto-Oncogene Proteins c-akt