title: Myelodysplastic syndrome (MDS)-associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia.
abstract: Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2-year-old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co-existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML.
authors.affiliation: Department of Pathology, Parkland Health and Hospital System, Children's Medical Center, UT Southwestern Medical Center, Dallas, Texas.
authors.forename: Kirthi R
authors.initials: KR
authors.lastname: Kumar
authors.forename: Prasad
authors.initials: P
authors.lastname: Koduru
authors.forename: Charles
authors.initials: C
authors.lastname: Timmons
authors.forename: Sara
authors.initials: S
authors.lastname: Monaghan
authors.forename: Maryellen
authors.initials: M
authors.lastname: Cavalier
authors.forename: Hung S
authors.initials: HS
authors.lastname: Luu
mesh_terms: D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000503:physiopathology; D009190:Myelodysplastic Syndromes / Q000235:genetics*
keywords: chronic myelogenous leukemia; cytogenetics; molecular genetics; myelodysplastic syndrome