title: Haemophilia in extreme immature preterm infants: increased risk for intracranial haemorrhage?
abstract: Haemophiliacs and extremely premature infants are both at an increased risk for intracranial haemorrhage; both conditions might be further elevating the risk. We report a case of a very immature preterm-infant of 26 gestational weeks (birth weight 635 g) with severe haemophilia A. Furthermore, we provide an overview of the published literature on this subject matter. Until now, deficiency of factor VIII or IX as a potential risk factor for ICH in preterm infants remains controversial. However, prophylactic substitution of factor VIII or IX in preterm infants with haemophilia may minimize the risk of bleeding complications and neurologic sequelae.
authors.affiliation: University of Würzburg, Paediatric Intensive Care and Neonatology Unit, Children's Hospital , Germany and.
authors.forename: Susanne
authors.initials: S
authors.lastname: Fink
authors.forename: Steffen
authors.initials: S
authors.lastname: Kunzmann
authors.forename: Oliver
authors.initials: O
authors.lastname: Andres
authors.forename: Matthias
authors.initials: M
authors.lastname: Eyrich
authors.forename: Verena
authors.initials: V
authors.lastname: Wiegering
mesh_terms: D000328:Adult; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000628:therapy*; D020300:Intracranial Hemorrhages / Q000209:etiology* / Q000517:prevention & control; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012307:Risk Factors
chemical_list: C427184:recombinant factor VIII SQ; D005169:Factor VIII