title: Immunomodulatory approaches for prevention and treatment of infectious diseases.
abstract: With increasing pathogen resistance to antibiotics, population ageing, and threat of pandemics there is a strong interest in the development of new approaches for the treatment of infectious diseases. Immunomodulatory therapies are defined as interventions that target the host rather than the pathogen, modulating the immune response with the aim of disease prevention or treatment. Our growing understanding of the immune system continues to offer novel drug targets and approaches for immunomodulatory interventions. In this review we will cover prominent examples of immunomodulatory therapies already in clinical use, as well as the recent advances in the development of new immunomodulators in ongoing clinical trials.
authors.affiliation: Department of Physiology and the Complex Traits Group, McGill University, Canada. Electronic address: anastasiya.nyzhnyk@mcgill.ca.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Nijnik
mesh_terms: D035843:Biomedical Research / Q000639:trends; D002986:Clinical Trials as Topic; D003140:Communicable Disease Control / Q000379:methods*; D003141:Communicable Diseases / Q000628:therapy*; D055808:Drug Discovery / Q000639:trends; D007155:Immunologic Factors / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods*
chemical_list: D007155:Immunologic Factors