title: Optical imaging of acute epileptic networks in mice.
abstract: The potential of intrinsic optical imaging and resting-state analysis under anesthetized conditions as a tool to study brain networks associated with epileptic seizures is investigated. Using an acute model of epileptiform activity, the 4-aminopyridine model in live mice, we observe the changes in resting-state networks with the onset of seizure activity and in conditions of spiking activity. Resting-state networks identified before and after the onset of epileptiform activity show both decreased and increased homologous correlations, with a small dependence on seizure intensity. The observed changes are not uniform across the different hemodynamic measures, suggesting a potential decoupling between blood flow and metabolism in the low-frequency networks. This study supports the need for a more extensive investigation of epileptic networks including more than one independent hemodynamic measurement.
authors.affiliation: École Polytechnique de Montréal, Department of Electrical Engineering, C.P. 6079 succ. Centre-ville, Montréal, Quebec H3C 3A7, Canada.
authors.forename: Edgar
authors.initials: E
authors.lastname: Guevara
authors.forename: Philippe
authors.initials: P
authors.lastname: Pouliot
authors.forename: Dang Khoa
authors.initials: DK
authors.lastname: Nguyen
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lesage
mesh_terms: D015761:4-Aminopyridine; D000208:Acute Disease; D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D061848:Optical Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000032:analysis
chemical_list: D010108:Oxyhemoglobins; D015761:4-Aminopyridine; D010100:Oxygen