title: Detrimental effects of metronidazole on the liver of freshwater common carp (Cyprinus carpio L.).
abstract: The widely used antibiotic metronidazole (MTZ) was investigated for its toxic effects on the liver of the common carp (Cyprinus carpio L.). The fish were exposed to 0.1, 0.5, and 2.5 mg/L MTZ in water for 30 days, and parameters that are indicative of liver damage and oxidative stress were measured. MTZ increased liver ethoxyresorufin-O-deethylase, malondialdehyde, and glutathione levels, and elevated the activities of superoxide dismutase, catalase, aspartate aminotransferase, and alanine aminotransferase. These parameters usually showed significant differences in the 0.5 and 2.5 mg/L MTZ groups compared to the control group (p < 0.05). These findings indicated that MTZ induced oxidative stress and caused liver damage in common carp, suggesting that measures should be taken to avoid contamination of surface waters with MTZ.
authors.affiliation: College of Life Science and Engineering, Shenyang University, No. 21 Wanghua Nan Street, Dadong District, Shenyang, 110044, People's Republic of China, hanjunyan@yahoo.cn.
authors.forename: Junyan
authors.initials: J
authors.lastname: Han
authors.forename: Huixin
authors.initials: H
authors.lastname: Cai
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Guangchun
authors.initials: G
authors.lastname: Liu
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002347:Carps; D002374:Catalase / Q000378:metabolism; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D005618:Fresh Water / Q000737:chemistry; D005978:Glutathione / Q000378:metabolism; D006540:Herbicides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008795:Metronidazole / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D006540:Herbicides; D014874:Water Pollutants, Chemical; D008795:Metronidazole; D002374:Catalase; D019363:Cytochrome P-450 CYP1A1; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione