title: Cytokine patterns in brain tumour progression.
abstract: Inflammation represents the immune system response to external or internal aggressors such as injury or infection in certain tissues. The body's response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, progression, and immunosuppression, rather than in building an effective antitumour defence. Using new proteomic technology, we have investigated serum profile of pro- (IL-1β , IL-6, IL-8, IL-12, GM-CSF, and TNF-α ) and anti-inflammatory cytokines (IL-4, IL-10), along with angiogenic factors (VEGF, bFGF) in order to assess tumoural aggressiveness. Our results indicate significant dysregulation in serum levels of cytokines and angiogenic factors, with over threefold upregulation of IL-6, IL-1β , TNF-α , and IL-10 and up to twofold upregulation of VEGF, FGF-2, IL-8, IL-2, and GM-CSF. These molecules are involved in tumour progression and aggressiveness, and are also involved in a generation of disease associated pain.
authors.affiliation: Victor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania.
authors.forename: Radu
authors.initials: R
authors.lastname: Albulescu
authors.forename: Elena
authors.initials: E
authors.lastname: Codrici
authors.forename: Ionela Daniela
authors.initials: ID
authors.lastname: Popescu
authors.forename: Simona
authors.initials: S
authors.lastname: Mihai
authors.forename: Laura Georgiana
authors.initials: LG
authors.lastname: Necula
authors.forename: Daniel
authors.initials: D
authors.lastname: Petrescu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Teodoru
authors.forename: Cristiana Pistol
authors.initials: CP
authors.lastname: Tanase
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D040901:Proteomics
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines