title: Recent advances in gene therapy of endometriosis.
abstract: Endometriosis is a gynecological disease that affects up to 10%-15% of all reproductive-age women worldwide. It is characterized by the presence of endometrial tissues outside the uterine cavity. Endometriosis is a complex disease; its pathogenesis includes altered steroid metabolism and immune system abnormalities such as inflammation, increased angiogenic activity in the peritoneal fluid and impaired recognition of ectopic endometrial cells. The development of endometriosis also depends on genetic, anatomical and environmental factors. Numerous surgical and medical approaches to treat endometriosis have been developed to date. However, complete resolution of the problem has not been achieved so far. Gene therapy holds exciting promise for the treatment of numerous disorders and current studies have indicated it can also be applied to endometriosis. The focus of this review is to summarize the pathogenetic background of the disease and to highlight current gene therapy approaches for this common gynecological disorder.
authors.forename: Anastasia N
authors.initials: AN
authors.lastname: Shubina
authors.forename: Anna A
authors.initials: AA
authors.lastname: Egorova
authors.forename: Vladislav S
authors.initials: VS
authors.lastname: Baranov
authors.affiliation: Ott's Institute for Obstetrics and Gynecology RAMS Saint-Petersburg Russia, 199034 Mendeleevskaya line, 3. ankiselev@yahoo.co.uk.
authors.forename: Anton V
authors.initials: AV
authors.lastname: Kiselev
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism; D050756:Cyclin-Dependent Kinase Inhibitor Proteins / Q000235:genetics / Q000378:metabolism; D065731:Cytochrome P-450 CYP2C19; D004715:Endometriosis / Q000473:pathology / Q000628:therapy*; D005260:Female; D015316:Genetic Therapy; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018919:Neovascularization, Physiologic / Q000235:genetics; D010330:Patents as Topic; D034622:RNA Interference
chemical_list: D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D018398:Homeodomain Proteins; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19