title: The cumulative risk of false-positive fecal occult blood test after 10 years of colorectal cancer screening.
abstract: BACKGROUND
  Annual colorectal cancer screening with fecal occult blood test (FOBT) is a noninvasive alternative to screening colonoscopy once every 10 years. If false-positive FOBT results are common, then many patients selecting an FOBT regimen will be exposed to the same invasive testing as those selecting a colonoscopy regimen. The objective of this study was to estimate the probability of experiencing a false-positive after receiving annual FOBT screening for 10 years.
  
  
  METHODS
  Medical records for patients aged 50 to 79 years receiving FOBT screening with Hemoccult Sensa between 1997 and 2009 at Group Health of Washington State captured the date and results of each FOBT, along with subsequent colorectal cancer diagnoses. We used logistic regression to analyze associations between patient characteristics and odds of a positive FOBT with no invasive cancer diagnosis within 1 year (FOBT+, CRC-). We estimated the probability of receiving at least one FOBT+, CRC- result after 10 years of screening.
  
  
  RESULTS
  We observed 181,950 FOBTs from 94,637 individuals. Older patients, males, and non-White patients were significantly more likely to receive FOBT+, CRC- results (P < 0.001 for all risk factors). After 10 years of annual FOBT, 23.0% [95% confidence interval (CI), 18.2-27.0] will receive at least one FOBT+, CRC- result.
  
  
  CONCLUSIONS
  Most patients participating in annual FOBT screening for 10 years will not have a positive result, reinforcing the potential value of this regimen as a noninvasive alternative to colonoscopy.
  
  
  CONCLUSIONS
  Annual stool-based screening is a screening alternative resulting in substantially fewer colonoscopies than once per decade colonoscopy.
authors.affiliation: Group Health Research Institute; Department of Biostatistics, School of Public Health, University of Washington; and Group Health Permanente, Seattle, WA 98101, USA. hubbard.r@ghc.org
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Hubbard
authors.forename: Eric
authors.initials: E
authors.lastname: Johnson
authors.forename: Raymond
authors.initials: R
authors.lastname: Hsia
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Rutter
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control; D055088:Early Detection of Cancer / Q000379:methods / Q000706:statistics & numerical data*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009780:Occult Blood