title: The use of topical tacrolimus 0.1% skin ointment for anterior segment conditions: a case series.
abstract: Tacrolimus (FK 506) is a macrolactam derivative with immunomodulatory and anti-inflammatory activity. Topical tacrolimus 0.03% has been used for inflammatory conditions of the anterior segment. This article adds to the literature on the off-license application of tacrolimus ointment, by describing the safe and effective use of the higher strength of 0.1% topical tacrolimus skin ointment in four patients. To our knowledge this is the first report of topical tacrolimus 0.1% ointment applied to the conjunctival sac for the treatment of atopic keratoconjunctivitis, vernal keratoconjunctivitis and the post-operative management of trabeculectomy and graft rejection in steroid responders.
authors.affiliation: Dunedin Eye Department, Dunedin Hospital, Dunedin, Otago, New Zealand. Email: nic_johnston@yahoo.com.
authors.forename: Poorna
authors.initials: P
authors.lastname: Abeysiri
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Johnston
authors.forename: Anthony C B
authors.initials: AC
authors.lastname: Molteno
keywords: anterior eye segment; inflammation; intraocular pressure; tacrolimus; topical administration