title: Treatment of mucosal leishmaniasis (L. infantum) with miltefosine in a patient with Good syndrome.
abstract: We report on a 76-year old patient with recurrent mucosal leishmaniasis. Multiple treatment regimens were administered. After the second relapse, immunologic workup and review of the patient's history revealed the presence of Good syndrome, characterized by immunodeficiency in patients with thymoma. The third relapse was treated with oral miltefosine with complete resolution of the lesions. Miltefosine is an option for treating Old World leishmaniasis (Leishmania infantum) and immunodeficiency should be considered in patients with recurrent leishmaniasis.
authors.affiliation: Swiss Tropical and Public Health Institute, Basel, Switzerland; Clinic of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
authors.forename: Marcel
authors.initials: M
authors.lastname: Stoeckle
authors.forename: Andreas
authors.initials: A
authors.lastname: Holbro
authors.forename: Andreas
authors.initials: A
authors.lastname: Arnold
authors.forename: Andreas
authors.initials: A
authors.lastname: Neumayr
authors.forename: Maya
authors.initials: M
authors.lastname: Weisser
authors.forename: Johannes
authors.initials: J
authors.lastname: Blum
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D006651:Histocytochemistry; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D018314:Leishmania infantum / Q000302:isolation & purification*; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine
keywords: Good syndrome; Hypogammaglobulinaemia; Leishmania infantum; Miltefosine; Mucosal leishmaniasis; Thymoma