title: Effect of dietary caloric restriction on the nociceptive threshold of rats that underwent aerobic and resistance exercise training.
abstract: The purpose of this study was to evaluate the effect that exercise and caloric restriction have on the nociceptive threshold of rats. Male Wistar rats were divided into two groups: one group that was fed ad libitum (FED) and another group that was subjected to dietary caloric restriction (CR). The CR group received 50% of the food the FED group received, for 4 weeks. Both groups were submitted to aerobic (AE) and resistance (RE) exercise training protocols performed in a rodent treadmill and in a weight-lifting exercise model, respectively. Mechanical and thermal nociceptive thresholds were measured by tail-flick and paw-withdrawal tests, respectively. Both exercise protocols produced antinociception, but there was no difference found between the FED and CR groups after either 1 or 4 weeks. Additionally, although dietary caloric restriction alone did not result in antinociception, it did increase the running time of animals during aerobic exercise and increased the load lifted in resistance exercise after 4 weeks. These results indicate that caloric restriction for 1 or 4 weeks did not alter the nociceptive threshold, but could play an important role in improvement of physical performance.
authors.affiliation: 1Department of Pharmacology, Federal University of Minas Gerais , Belo Horizonte , Brazil.
authors.forename: Giovane S
authors.initials: GS
authors.lastname: Galdino
authors.forename: Igor D
authors.initials: ID
authors.lastname: Duarte
authors.forename: Andrea C
authors.initials: AC
authors.lastname: Perez
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D008297:Male; D059225:Nociception / Q000502:physiology*; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats