title: Correlation between serum 25-hydroxyvitamin D level and plasminogen activator inhibitor 1 in type 2 diabetic patients.
abstract: BACKGROUND
  It has been approved that vitamin D deficiency has a role in increasing the rate of cardio-vascular diseases in diabetic patients with unknown mechanism. The effects of vitamin D on hemostasis and its inflammatory mechanisms have been proposed as possible causes of cardio-vascular diseases in these patients. Also, high level of plasminogen activator inhibitor- type 1 (PAI-1) has been identified as a risk factor for cardio-vascular diseases in diabetic patients. The goal of this survey was to investigate the relation between vitamin D level and level of PAI-1 as a thrombotic marker.
  
  
  METHODS
  180 patients with type 2 diabetes mellitus enrolled for the study. The serum level of PAI-1 was measured by enzyme linked immune-assay and was compared with calcium metabolism markers including vitamin D, parathormon hormone, fasting blood sugar, calcium, and phosphorous.
  
  
  RESULTS
  There was statistically significant relation between PAI-1 with fasting blood sugar and high density lipoprotein, but there was no significant relation between PAI-1 with vitamin D level and other cardio-vascular disease variables.
  
  
  CONCLUSIONS
  It seems that serum level of vitamin D has no relation with PAI-1 in diabetic patients, although further investigations are required to confirm these findings.
authors.affiliation: Mashhad University of Medical Sciences, Endocrine Research Center- Ghaem Hospital- Ahmad Abad Street, Iran.. bonakdaransh@mums.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Mansouritorghabe
authors.forename: Shokoufeh
authors.initials: S
authors.lastname: Bonakdaran
authors.forename: Seyed Javad
authors.initials: SJ
authors.lastname: Hossieni
mesh_terms: D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D017395:Plasminogen Activator Inhibitor 1; D014807:Vitamin D; C104450:25-hydroxyvitamin D