title: PK/PD models in antibacterial development.
abstract: There is an urgent need for novel antibiotics to treat life-threatening infections caused by bacterial 'superbugs'. Validated in vitro pharmacokinetic/pharmacodynamic (PK/PD) and animal infection models have been employed to identify the most predictive PK/PD indices and serve as key tools in the antibiotic development process. The results obtained can be utilized for optimizing study designs in order to minimize the cost and duration of clinical trials. This review outlines the key in vitro PK/PD and animal infection models which have been extensively used in antibiotic discovery and development. These models have shown great potential in accelerating drug development programs and will continue to make significant contributions to antibiotic development.
authors.affiliation: Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia.
authors.forename: Tony
authors.initials: T
authors.lastname: Velkov
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Bergen
authors.forename: Jaime
authors.initials: J
authors.lastname: Lora-Tamayo
authors.forename: Cornelia B
authors.initials: CB
authors.lastname: Landersdorfer
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics* / Q000494:pharmacology*; D055808:Drug Discovery / Q000379:methods*; D008826:Microbial Sensitivity Tests / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents