title: Bifunctional polypyridyl-Ru(II) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy.
abstract: The synthesis, optical properties and efficiency of new multifunctional nanoparticles as theranostic (fluorescence/MRI/PDT) agents are described. They are based on a polysiloxane network and surrounded by gadolinium(III) chelates and ruthenium(II) complexes. The size of the nanoparticles is maintained under 5 nm in order to permit their efficient elimination from the body. Their potential use as a theranostic agent (PDT/MRI) is described. The magnetic properties of the nanoparticles are studied by relaxometry (r1 = 9.21 mM(-1) s(-1) at 40 MHz; r2/r1 = 1.14) and the signal enhancement is validated by the acquisition of phantoms on a 3 T MRI imager. The therapeutic potential for photodynamic therapy of the nanoparticles has been studied in vitro on HEK293 cells and an effective quantum yield of 0.33 for (1)O2 production has been determined in deuterated water.
authors.affiliation: Institut Lumière-Matière - Université de Lyon, Équipe Fennec UMR CNRS n°, 5306 - 69622 Villeurbanne, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Truillet
authors.forename: Francois
authors.initials: F
authors.lastname: Lux
authors.forename: Juliette
authors.initials: J
authors.lastname: Moreau
authors.forename: Mickaël
authors.initials: M
authors.lastname: Four
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
authors.forename: Sylviane
authors.initials: S
authors.lastname: Chevreux
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Boeuf
authors.forename: Pascal
authors.initials: P
authors.lastname: Perriat
authors.forename: Céline
authors.initials: C
authors.lastname: Frochot
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Antoine
authors.forename: Philippe
authors.initials: P
authors.lastname: Dugourd
authors.forename: Christophe
authors.initials: C
authors.lastname: Portefaix
authors.forename: Christine
authors.initials: C
authors.lastname: Hoeffel
authors.forename: Muriel
authors.initials: M
authors.lastname: Barberi-Heyob
authors.forename: Christine
authors.initials: C
authors.lastname: Terryn
authors.forename: Laurence
authors.initials: L
authors.lastname: van Gulick
authors.forename: Gilles
authors.initials: G
authors.lastname: Lemercier
authors.forename: Olivier
authors.initials: O
authors.lastname: Tillement
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D008027:Light; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D012428:Ruthenium / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D017319:Photosensitizing Agents; D012833:Siloxanes; D026082:Singlet Oxygen; D012428:Ruthenium; D005682:Gadolinium