title: Erythema multiforme vs. DRESS syndrome associated with the combined use of lamotrigine and cyclobenzaprine: a case report.
abstract: Lamotrigine is FDA-approved as a maintenance treatment of bipolar disorder, but its common off-label uses include bipolar depression and antidepressant augmentation in patients with major depressive disorder. Among other adverse effects, cutaneous reactions, particularly erythema multiforme, are cited as concerns during treatment with this medication. In order to minimize the risk of cutaneous side effect, efforts have been made to identify factors associated with a higher rate of lamotrigine-induced rash. We report here a case of Drug Reaction with Eosinophilia and Systemic Symptoms apparently precipitated by the associated use of lamotrigine and cyclobenzaprine.
authors.affiliation: University of Texas Medical School at Houston, Houston, TX 77030, USA. Lindsaymbicknell@gmail.com
authors.forename: Lindsay T Morgan
authors.initials: LT
authors.lastname: Bicknell
authors.forename: Marsal
authors.initials: M
authors.lastname: Sanches
authors.forename: Dawnelle J
authors.initials: DJ
authors.lastname: Schatte
mesh_terms: D000639:Amitriptyline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D018692:Antimanic Agents / Q000009:adverse effects*; D015283:Citalopram / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D004347:Drug Interactions; D004359:Drug Therapy, Combination / Q000009:adverse effects; D004802:Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008875:Middle Aged; D056687:Off-Label Use; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*; D013577:Syndrome; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000639:Amitriptyline; D000929:Antidepressive Agents, Tricyclic; D018692:Antimanic Agents; D015283:Citalopram; D000077213:Lamotrigine; D017367:Selective Serotonin Reuptake Inhibitors; D014227:Triazines; C004704:cyclobenzaprine