title: Timing it right: precise ON/OFF switches for Rho1 and Cdc42 GTPases in cytokinesis.
abstract: In many eukaryotes, cytokinesis requires an actomyosin contractile ring that is crucial for cell constriction and new membrane organization. Two studies in this issue (Onishi et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201302001 and Atkins et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201301090) establish that precise activation and/or inactivation of Rho1 and Cdc42 GTPases is important for the correct order and successful completion of events downstream of actomyosin ring constriction in budding yeast.
authors.affiliation: Temasek Life Sciences Laboratory, 2 Department of Biological Sciences, and 3 Mechanobiology Institute, National University of Singapore, Singapore 117604.
authors.forename: Mohan K
authors.initials: MK
authors.lastname: Balasubramanian
authors.forename: Evelyn Yaqiong
authors.initials: EY
authors.lastname: Tao
mesh_terms: D048749:Cytokinesis; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008938:Mitosis; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D004718:Saccharomycetales / Q000201:enzymology*; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: C418803:Cyk3 protein, S cerevisiae; D008869:Microtubule-Associated Proteins; D029701:Saccharomyces cerevisiae Proteins; C051302:RHO1 protein, S cerevisiae; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae; D020741:rho GTP-Binding Proteins