title: Intriguing arms race between phages and hosts and implications for better anti-infectives.
abstract: Phages are viruses of bacteria. The interaction between phages and bacteria shall boost both parties' evolution. During the lengthy coevolution, the host has evolved multiple mechanisms against the phages. The phages also have evolved unique strategies to facilitate their own survival accordingly. This article summarizes the measures and countermeasures employed by the both parties and their implications for better biomedicines.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Changwu
authors.initials: C
authors.lastname: Huang
authors.forename: Weihua
authors.initials: W
authors.lastname: Pan
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000821:virology*; D001426:Bacterial Proteins / Q000235:genetics*; D001435:Bacteriophages / Q000235:genetics* / Q000302:isolation & purification; D005075:Biological Evolution; D035843:Biomedical Research; D064112:Clustered Regularly Interspaced Short Palindromic Repeats / Q000502:physiology; D015280:DNA Restriction-Modification Enzymes / Q000378:metabolism; D012329:RNA, Bacterial / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D015280:DNA Restriction-Modification Enzymes; D012329:RNA, Bacterial