title: Cancer preventive effects of whole cell type immunization against mice Ehrlich tumors.
abstract: BACKGROUND
  Effects of whole cell type immunization on mice Ehrlich tumours were evaluated.
  
  
  METHODS
  After preliminary study, mice were divided two major groups; 1 x 1000 and 100 x 1000 live Ehrlich cell transferred major groups, each divided into four subgroups (n: 10). Study groups were immunized with Ehrlich cell lysates in 0, 3, 7, 14th days and after 30 days of last immunization, live Ehrlich cells were transferred. Mice were observed for six months and evaluated for total and cancer free days.
  
  
  RESULTS
  Out of 100 x 1000 cell transferred solid type study group, all study group mean and tumour free periods were statistically longer than control groups. All 1 x 1000 Ehrlich cell transferred study groups survived significantly longer than 100 x 1000 Ehrlich cell transferred groups.
  
  
  CONCLUSIONS
  Ehrlich mice tumours were prevented and survival prolonged with whole cell type immunization. Effects are related to the number of transferred tumor cells.
authors.affiliation: Department of General Surgery, Bezmialem Vakif University, Istanbul, Turkey. erhanaysan@hotmail.com
authors.forename: Erhan
authors.initials: E
authors.lastname: Aysan
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Bayrak
authors.forename: Esra
authors.initials: E
authors.lastname: Aydemir
authors.forename: Dilek
authors.initials: D
authors.lastname: Telci
authors.forename: Fikrettin
authors.initials: F
authors.lastname: Sahin
authors.forename: Cem
authors.initials: C
authors.lastname: Yardimci
authors.forename: Mahmut
authors.initials: M
authors.lastname: Muslumanoglu
mesh_terms: D000818:Animals; D001201:Ascites; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D064987:Cell- and Tissue-Based Therapy; D005260:Female; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D015996:Survival Rate; D014407:Tumor Cells, Cultured