title: Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma.
abstract: Associations between traffic-related air pollution and incident childhood asthma can be strengthened by analysis of gene-environment interactions, but studies have typically been limited by lack of study power. We combined data from six birth cohorts on: asthma, eczema and allergic rhinitis to 7/8 years, and candidate genes. Individual-level assessment of traffic-related air pollution exposure was estimated using land use regression or dispersion modeling. A total of 11,760 children were included in the Traffic, Asthma and Genetics (TAG) Study; 6.3 % reported physician-diagnosed asthma at school-age, 16.0 % had asthma at anytime during childhood, 14.1 % had allergic rhinitis at school-age, 10.0 % had eczema at school-age and 33.1 % were sensitized to any allergen. For GSTP1 rs1138272, the prevalence of heterozygosity was 16 % (range amongst individual cohorts, 11-17 %) and homozygosity for the minor allele was 1 % (0-2 %). For GSTP1 rs1695, the prevalence of heterozygosity was 45 % (40-48 %) and homozygosity for the minor allele, 12 % (10-12 %). For TNF rs1800629, the prevalence of heterozygosity was 29 % (25-32 %) and homozygosity for the minor allele, 3 % (1-3 %). TAG comprises a rich database, the largest of its kind, for investigating the effect of genotype on the association between air pollution and childhood allergic disease.
authors.affiliation: School of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, BC, V6T1Z3, Canada.
authors.forename: Elaina A
authors.initials: EA
authors.lastname: MacIntyre
authors.forename: Christopher
authors.initials: C
authors.lastname: Carlsten
authors.forename: Meaghan
authors.initials: M
authors.lastname: MacNutt
authors.forename: Elaine
authors.initials: E
authors.lastname: Fuertes
authors.forename: Eric
authors.initials: E
authors.lastname: Melén
authors.forename: Carla M T
authors.initials: CM
authors.lastname: Tiesler
authors.forename: Ulrike
authors.initials: U
authors.lastname: Gehring
authors.forename: Ursula
authors.initials: U
authors.lastname: Krämer
authors.forename: Claudia
authors.initials: C
authors.lastname: Klümper
authors.forename: Marjan
authors.initials: M
authors.lastname: Kerkhof
authors.forename: Moira
authors.initials: M
authors.lastname: Chan-Yeung
authors.forename: Anita L
authors.initials: AL
authors.lastname: Kozyrskyj
authors.forename: Dietrich
authors.initials: D
authors.lastname: Berdel
authors.forename: Carl Peter
authors.initials: CP
authors.lastname: Bauer
authors.forename: Olf
authors.initials: O
authors.lastname: Herbarth
authors.forename: Mario
authors.initials: M
authors.lastname: Bauer
authors.forename: Beate
authors.initials: B
authors.lastname: Schaaf
authors.forename: Sibylle
authors.initials: S
authors.lastname: Koletzko
authors.forename: Goran
authors.initials: G
authors.lastname: Pershagen
authors.forename: Bert
authors.initials: B
authors.lastname: Brunekreef
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
authors.forename: Michael
authors.initials: M
authors.lastname: Brauer
mesh_terms: D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D004485:Eczema / Q000453:epidemiology / Q000235:genetics; D004781:Environmental Exposure; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000235:genetics; D008297:Male; D009585:Nitrogen Dioxide / Q000009:adverse effects; D018384:Oxidative Stress / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012220:Rhinitis / Q000453:epidemiology / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D001335:Vehicle Emissions; D051549:Glutathione S-Transferase pi; D009585:Nitrogen Dioxide