title: Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose.
abstract: The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.
authors.affiliation: Institute of Experimental Botany, Academy of Sciences of Czech Republic, v.v.i., Rozvojova 263, Prague 6, 165 02, Czech Republic.
authors.forename: Marcela
authors.initials: M
authors.lastname: Dvorakova
authors.forename: Radim
authors.initials: R
authors.lastname: Nencka
authors.forename: Milan
authors.initials: M
authors.lastname: Dejmek
authors.forename: Eva
authors.initials: E
authors.lastname: Zbornikova
authors.forename: Anna
authors.initials: A
authors.lastname: Brezinova
authors.forename: Marie
authors.initials: M
authors.lastname: Pribylova
authors.forename: Radek
authors.initials: R
authors.lastname: Pohl
authors.forename: Marie E
authors.initials: ME
authors.lastname: Migaud
authors.forename: Tomas
authors.initials: T
authors.lastname: Vanek
mesh_terms: D002254:Carbonates / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation; D038961:O-Acetyl-ADP-Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D056564:Sirtuin 1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D002254:Carbonates; D004791:Enzyme Inhibitors; D038961:O-Acetyl-ADP-Ribose; C447939:SIRT1 protein, human; D056564:Sirtuin 1