title: A case of propylthiouracil-induced antineutrophilic cytoplasmic antibody-positive vasculitis successfully treated with radioactive iodine.
abstract: Antineutrophilic cytoplasmic antibody (ANCA) associated vasculitis is one of the rare complications of propylthiouracil treatment. Having a variable clinical spectrum, it may be presented with both skin limited vasculitis and life-threatening systemic vasculitis. In this study, we present a case that developed ANCA-positive vasculitis with skin and kidney involvement (hematuria and proteinuria) six months after propylthiouracil treatment was initiated for toxic nodular goiter. Proteinuria recovered dramatically subsequent to radioactive iodine treatment following ceasing the drug.
authors.affiliation: Department of Rheumatology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Turkey. cemalbes@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Bes
authors.forename: O
authors.initials: O
authors.lastname: Dikbaş
authors.forename: E
authors.initials: E
authors.lastname: Keskin
authors.forename: Ö
authors.initials: Ö
authors.lastname: Kaptanoğulları
authors.forename: M
authors.initials: M
authors.lastname: Soy
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000139:chemically induced* / Q000532:radiotherapy*; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects*; D012074:Remission Induction
chemical_list: D013956:Antithyroid Agents; D007457:Iodine Radioisotopes; D011441:Propylthiouracil