title: Development and characterization of stable nanovesicular carrier for drug delivery.
abstract: Lipid vesicles are an important drug carrier which can serve for controlled delivery of drugs; however, these vesicles are quite unstable at ambient temperature and require stringent storage condition. Present work was done to develop a stable vesicular system for drug delivery. Vesicles of ceramide-2, cholesterol, cholesterol sulfate, and palmitic acid were prepared and compared with phosphatidylcholine vesicles for physicochemical parameters and accelerated stability. Diclofenac sodium was used as a model drug. Based on physicochemical parameter and in vitro release PCV-3 and CV-3 were selected for further studies in three different accelerated stability conditions. PCV-3 showed moderate changes at 4°C but was severely affected at 25°C and 40°C. CV-3 showed stable characteristics at 4°C and 25°C whereas at 40°C, CV-3 showed signs of slight modification owing to moisture absorption. Based on the study, CV-3 containing highest content of palmitic acid was found to be most stable.
authors.affiliation: Department of Pharmaceutics, I.T.S. Paramedical (Pharmacy) College , Muradnagar, Ghaziabad, UP , India.
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Gaur
authors.forename: Suresh
authors.initials: S
authors.lastname: Purohit
authors.forename: Yatendra
authors.initials: Y
authors.lastname: Kumar
authors.forename: Shikha
authors.initials: S
authors.lastname: Mishra
authors.forename: Anil
authors.initials: A
authors.lastname: Bhandari
mesh_terms: D002626:Chemistry, Pharmaceutical; D004008:Diclofenac / Q000737:chemistry; D065546:Drug Liberation; D004355:Drug Stability; D008081:Liposomes / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry
chemical_list: D008081:Liposomes; D010713:Phosphatidylcholines; D004008:Diclofenac
keywords: in vitro drug release; polydispersity index; stability; vesicles