title: Near-contiguous spin echo imaging using matched-phase RF and its application in velocity-selective arterial spin labeling.
abstract: OBJECTIVE
  The minimum slice spacing in multislice imaging is limited by inter-slice crosstalk due to an imperfect slice profile. This study sought to minimize the slice spacing using matched-phase RF pulses and demonstrate its application in cerebral blood flow imaging using velocity-selective arterial spin labeling.
  
  
  METHODS
  A spin-echo matched-phase 90°-180° RF pair was designed using Shinnar-Le Roux algorithm in order to improve the slice profile of longitudinal magnetization, which plays a more critical role in creating interslice crosstalk than transverse magnetization. Both transverse and longitudinal slice profiles were compared between matched-phase RF and sinc-based RF pulses in simulations and measurements. Velocity-selective arterial spin labeling was performed in normal volunteers using both RF pulses and standard deviation of cerebral blood flow time series was calculated to examine ASL signal stability.
  
  
  RESULTS
  Using designed matched-phase RF, the longitudinal slice profile was sharpened without signal-to-noise ratio loss. In velocity-selective arterial spin labeling imaging, the temporal standard deviation of cerebral blood flow measurements was reduced from 48 mL/100 g/min to 32 mL/100 g/min by 33% using matched-phase RF pulses, and as a result, cerebral blood flow image quality improved.
  
  
  CONCLUSIONS
  This study reports that near-contiguous multislice imaging can be achieved using matched-phase RF pulses without compromising signal-to-noise ratio and signal stability.
authors.affiliation: Department of Radiology, Stanford University, Stanford, California, USA.
authors.forename: Zungho
authors.initials: Z
authors.lastname: Zun
authors.forename: Brian A
authors.initials: BA
authors.lastname: Hargreaves
authors.forename: John
authors.initials: J
authors.lastname: Pauly
authors.forename: Greg
authors.initials: G
authors.lastname: Zaharchuk
mesh_terms: D000465:Algorithms; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D064368:Healthy Volunteers; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009038:Motion; D019047:Phantoms, Imaging; D011846:Radio Waves; D059629:Signal-To-Noise Ratio; D013113:Spin Labels
chemical_list: D013113:Spin Labels
keywords: VSASL; arterial spin labeling; cerebral blood flow; matched-phase RF