title: Dietary phosphorus and kidney disease.
abstract: High serum phosphate is linked to poor health outcome and mortality in chronic kidney disease (CKD) patients before or after the initiation of dialysis. Therefore, maintenance of normal serum phosphate levels is a major concern in the clinical care of this population with dietary phosphorus restriction and/or use of oral phosphate binders considered to be the best corrective care. This review discusses (1) evidence for an association between serum phosphate levels and bone and cardiovascular disease (CVD) in CKD patients as well as progression of kidney disease itself; (2) the relationship between serum phosphate and dietary phosphorus intake; and (3) implications from these data for future research. Increasing our understanding of the relationship between altered phosphorus metabolism and disease in CKD patients may clarify the potential role of excess dietary phosphorus as a risk factor for disease in the general population.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, New York, New York.
authors.forename: Jaime
authors.initials: J
authors.lastname: Uribarri
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000378:metabolism; D001847:Bone Diseases / Q000097:blood* / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000378:metabolism; D010710:Phosphates / Q000097:blood* / Q000378:metabolism; D016226:Phosphorus, Dietary / Q000008:administration & dosage / Q000009:adverse effects*; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000401:mortality
chemical_list: D010710:Phosphates; D016226:Phosphorus, Dietary
keywords: atherosclerosis; bone disease; cardiovascular disease; chronic kidney disease; hyperparathyroidism; nutrition