title: Safety and efficacy of fingolimod in treatment-naïve multiple sclerosis patients.
abstract: Fingolimod was recently approved for use in the United States after two phase III trials confirmed its effectiveness in reducing disease activity in relapsing-remitting multiple sclerosis. These positive results, coupled with the important fact that this is the first oral disease-modifying therapy, has lead to considerable enthusiasm amongst physicians and patients. However, fingolimod is associated with rare but serious adverse events. In addition, unlike conventional disease-modifying therapies, cardiopulmonary, ophthalmological and dermatological safety monitoring unfamiliar to both neurologists and patients is required before and during treatment. This paper will discuss these issues from the perspective of using fingolimod as a first-line disease-modifying therapy in treatment-naïve relapsing-remitting multiple sclerosis patients.
authors.affiliation: Section of Neurology, University of Manitoba, Health Sciences Centre, GF543-820 Sherbrook Street, Winnipeg, MB, Canada.
authors.forename: James J
authors.initials: JJ
authors.lastname: Marriott
keywords: disease-modifying therapy; fingolimod; multiple sclerosis; treatment-naïve