title: [Effects of abdominal adhesion-preventing 4% icodextrin solution on healing of bowel anastomoses].
abstract: BACKGROUND
  We aimed to introduce the efficiency of 4% icodextrin solution on preventing adhesions and its effect on anastomotic healing, together with biochemical parameters.
  
  
  METHODS
  In total, 40 rats were divided into four groups of 10 rats each as Group A (abrasion+icodextrin), Group B (abrasion), Group C (anastomosis+icodextrin), and Group D (anastomosis). Adhesion grade, anastomotic bursting pressure, histopathological analysis, tissue hydroxyproline level, and serum myeloperoxidase (MPO), nitric oxide (NO), and malondialdehyde (MDA) values were examined.
  
  
  RESULTS
  Adhesion score was significantly lower in Group A than in Group B and significantly lower in Group C than in Group D (p=0.003577, p=0.001612). No difference in anastomoses healing was determined between Group C and Group D (p=0.816). Hydroxyproline level was significantly higher in Group A than in Group B and significantly higher in Group C than in Group D (p=0.001, p=0.0001). There were no differences in NO and MDA levels between Group A and Group B, but values were significantly lower in Group C than in Group D (p=0.434, p=0.001, p=0.116, p=0.018). MPO level was significantly lower in Group A than in Group B and significantly lower in Group C than in Group D (p=0.0001, p=0.0001).
  
  
  CONCLUSIONS
  Based on our results, 4% icodextrin solution evidently decreased the formation of adhesion without negatively affecting the anastomotic healing. We also reported herein the biochemical and histopathological results and adhesion scores.
authors.affiliation: Department of Gastroenterologic Surgery, Diyarbakır Training and Research Hospital, Diyarbakır, Turkey. okaykocdr@yahoo.com.tr
authors.forename: Okay
authors.initials: O
authors.lastname: Koç
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dağ
authors.forename: Ahmet Koray
authors.initials: AK
authors.lastname: Ocal
authors.forename: Mustafa Musa
authors.initials: MM
authors.lastname: Dirlik
authors.forename: Ulkü
authors.initials: U
authors.lastname: Cömelekoğlu
authors.forename: Lülüfer Tamer
authors.initials: LT
authors.lastname: Gümüş
authors.forename: Ebru
authors.initials: E
authors.lastname: Serinsöz
authors.forename: Emine Arzu
authors.initials: EA
authors.lastname: Kanık
authors.forename: Hamdi
authors.initials: H
authors.lastname: Akça
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D003106:Colon / Q000187:drug effects / Q000601:surgery*; D005936:Glucans / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D000077607:Icodextrin; D008297:Male; D051381:Rats; D000267:Tissue Adhesions / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D005936:Glucans; D000077607:Icodextrin; D005947:Glucose