title: [Low-dose tadalafil for erectile dysfunction following pelvic fracture-induced urethral injury: clinical observation of 42 cases].
abstract: OBJECTIVE
  To evaluate the efficacy of daily low-dose tadalafil in the treatment of erectile dysfunction (ED) following pelvic fracture-induced urethral injury (PFUI).
  
  
  METHODS
  Based on the length of time between pelvic fracture and the patients' clinic visit, we divided 42 PFUI-caused ED patients into groups A (< 1 month), B (6-24 months) and C (> 24 months). We treated them with tadalafil at 5 mg daily for 12 weeks consecutively, followed by evaluation of the therapeutic effect using IIEF-5 questionnaire and Sexual Encounter Profile (SEP) diaries.
  
  
  RESULTS
  Thirty-four patients (83.3%) completed the investigation and all responded well to tadalafil medication. Group A showed significant differences from B and C in the increase of IIEF-5 scores and the positive rate of SEP.
  
  
  CONCLUSIONS
  Daily low-dose tadalafil helps penile rehabilitation in ED patients following PFUI, and the earlier the medication is initiated, the better the effect will be.
authors.affiliation: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Tang
authors.forename: Yu
authors.initials: Y
authors.lastname: Gan
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Zhang
authors.forename: Xiang-Sheng
authors.initials: XS
authors.lastname: Zhu
authors.forename: Xian-Zhen
authors.initials: XZ
authors.lastname: Jiang
authors.forename: Le-Ye
authors.initials: LY
authors.lastname: He
authors.forename: Jian-Fu
authors.initials: JF
authors.lastname: Yang
mesh_terms: D000328:Adult; D002243:Carbolines / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology*; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D008297:Male; D010388:Pelvis / Q000293:injuries; D000068581:Tadalafil; D016896:Treatment Outcome; D014521:Urethra / Q000293:injuries*
chemical_list: D002243:Carbolines; D000068581:Tadalafil