title: High-powered percutaneous microwave ablation of stage I medically inoperable non-small cell lung cancer: a preliminary study.
abstract: OBJECTIVE
  To retrospectively evaluate the feasibility and outcome of using high-powered percutaneous microwave ablation (MWA) in treating medically inoperable early stage non-small cell lung cancer.
  
  
  METHODS
  From November 2010 to June 2012, 15 patients underwent CT-guided MWA of 15 tumours in 16 sessions. One patient had a second ablation session for local tumour progression. Each tumour had a diameter of 40 mm or less (median 24 mm). Treatment outcome was evaluated using modified response evaluation criteria in solid tumours criteria based on follow-up contrast-enhanced CT studies and 18-F fluorodeoxyglucose positron emission tomography scans.
  
  
  RESULTS
  Thirty-three ablation cycles of 15 tumours were performed in 16 sessions (2.1 per session), with a median duration of 2.5 min per ablation. Treatment was completed in all cases with no 30-day mortality. At a median follow-up period of 1 year, local progression was identified following 5/16 (31%) ablation sessions. Eleven out of 16 (69%) of MWAs had shown local treatment response, with 9/11 displaying complete response and 2/11 displaying partial response. Local progression on follow up was predominantly seen in pleural-based tumours that were greater than 30 mm in longest axial diameter (4/5 cases). The main adverse event was a pneumothorax, which occurred in 10/16 (63%) of procedures, but a chest tube was only required in 2/16 (13%) cases.
  
  
  CONCLUSIONS
  Percutaneous MWA in early stage non-small cell lung cancer is well tolerated and has promising midterm outcomes.
authors.affiliation: Department of Medical Imaging, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors.forename: Howard
authors.initials: H
authors.lastname: Liu
authors.forename: Karin
authors.initials: K
authors.lastname: Steinke
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D009367:Neoplasm Staging; D010865:Pilot Projects; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: ablation; lung cancer; lung tumour; microwave ablation; percutaneous; thermal therapy