title: Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents.
abstract: Quaternized polymers mimicking the antimicrobial peptides were created by tuning the side-chain amphiphilicity using a first-time approach of post-functionalization. They displayed excellent efficacy against pathogenic bacteria even in human plasma and membrane disruptive mode of action. The optimized polymers and degraded products were non-hemolytic.
authors.affiliation: Bioorganic and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560064, India. jayanta@jncasr.ac.in.
authors.forename: Divakara S S M
authors.initials: DS
authors.lastname: Uppu
authors.forename: Padma
authors.initials: P
authors.lastname: Akkapeddi
authors.forename: Goutham B
authors.initials: GB
authors.lastname: Manjunath
authors.forename: Venkateswarlu
authors.initials: V
authors.lastname: Yarlagadda
authors.forename: Jiaul
authors.initials: J
authors.lastname: Hoque
authors.forename: Jayanta
authors.initials: J
authors.lastname: Haldar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D006461:Hemolysis; D053878:Hemolytic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010949:Plasma / Q000187:drug effects / Q000382:microbiology; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D053878:Hemolytic Agents; D013501:Surface-Active Agents