title: [Correlation of IPSS with IL-8 and COX-2 levels in patients with benign prostatic hyperplasia and prostatitis].
abstract: OBJECTIVE
  To investigate the correlation of International Prostate Symptom Score (IPSS) with the levels of interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in the prostate tissue and expressed prostatic secretion (EPS) in patients with benign prostatic hyperplasia (BPH) complicated by prostatitis.
  
  
  METHODS
  We divided 80 BPH patients to be treated by transurethral resection of the prostate (TURP) into a simple BPH group (n = 30) and a BPH with prostatitis group (n = 50) based on the pathologic features. We statistically analyzed IPSS and the levels of IL-8 and COX-2 in EPS before surgery and the IL-8 and COX-2 levels in the prostate tissue after surgery.
  
  
  RESULTS
  IPSS was positively correlated with the IL-8 and COX-2 levels in the prostate tissue and EPS of the BPH patients, moderately in the simple hyperplasia group (r > 0.5) and highly in the other (r > 0.8). The levels of IL-8 and COX-2 in the prostate tissue and EPS were significantly higher in the BPH with prostatitis group than in the simple BPH group (P < 0.05).
  
  
  CONCLUSIONS
  The levels of IL-8 and COX-2 in EPS indirectly reflect those in the prostate tissue. IPSS and the levels of IL-8 and COX-2 in EPS can help determine whether BPH is complicated by histological prostatic inflammation.
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China. cdg998@sina.com
authors.forename: Di-Ang
authors.initials: DA
authors.lastname: Chen
authors.forename: Xing-Zhi
authors.initials: XZ
authors.lastname: Yang
authors.forename: Pei-Hai
authors.initials: PH
authors.lastname: Zhang
authors.forename: Guang-Sen
authors.initials: GS
authors.lastname: Li
authors.forename: De-Gui
authors.initials: DG
authors.lastname: Chang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D011472:Prostatitis / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human