title: Birthweight and fasting glucose and insulin levels: results from the Aboriginal Birth Cohort Study.
abstract: OBJECTIVE
  To examine the relationships between birthweight, current size, and fasting glucose and fasting insulin levels in Aboriginal adolescents.
  
  
  METHODS
  Longitudinal prospective study of a Northern Territory Aboriginal birth cohort of 686 Aboriginal babies born at the Royal Darwin Hospital between January 1987 and March 1990, and followed up between December 2006 and January 2008 in over 40 NT locations.
  
  
  METHODS
  Fasting insulin and glucose levels, adjusted for gestational age, sex and contemporary age.
  
  
  RESULTS
  Among the 134 participants with complete data, those with fetal growth restriction (FGR) or low birthweight (LBW) at birth were not overweight at 18 2013s. In these circumstances, birthweight showed a significant positively directed association with fasting glucose levels (P = 0.002). Current weight showed a significant and positively directed association with both fasting insulin (P < 0.001) and fasting glucose levels (P = 0.001), and current height showed a significant and positively directed association with insulin levels (P = 0.006).
  
  
  CONCLUSIONS
  Birthweight was only positively associated with fasting glucose levels, with no association with fasting insulin levels. The high-risk combination for type 2 diabetes of LBW or FGR with later overweight or obesity was rare in this adolescent Aboriginal population.
authors.affiliation: Menzies School of Health Research, Darwin, NT, Australia. sue.sayers@menzies.edu.au
authors.forename: Susan M
authors.initials: SM
authors.lastname: Sayers
authors.forename: Susan A
authors.initials: SA
authors.lastname: Mott
authors.forename: Kay D
authors.initials: KD
authors.lastname: Mann
authors.forename: Mark S
authors.initials: MS
authors.lastname: Pearce
authors.forename: Gurmeet R
authors.initials: GR
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism*; D001827:Body Height; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000208:ethnology; D008137:Longitudinal Studies; D008297:Male; D015233:Models, Statistical; D015876:Northern Territory; D011446:Prospective Studies; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin