title: [Impulse control behaviors associated with antiparkinsonian medications].
abstract: In some patients, impulse control behaviours can be triggered by dopaminergic replacement therapy, particularly dopamine agonist drugs: hobbyism, punding (stereotyped behaviours), compulsive buying, binge eating disorder, pathological gamgling, hypersexuality, hedonistic homeostatic dysregulation syndrome ... The pathogenesis of these behaviours: is not well understood, but likely involves aberrant changes in the dopaminergic pathways that mediate motivation i.e., a dopaminergic "overdose" in meso-cortico-limbic circuits, An early diagnosis is difficult, but mandatory to prevent the occurrence of devastating familial, marital, professional, socio-economic, medical and medico-legal consequences. Their management is not yet well standardized. Patients and caregivers should be warned about impulse control behaviours before starting dopamine agonists and monitoring for such behaviours while on therapy is requested.
authors.affiliation: Aspirante FNRS, CHU de Liege. parkinson@ulg.ac.be
authors.forename: F
authors.initials: F
authors.lastname: Depierreux-Lahaye
authors.forename: J
authors.initials: J
authors.lastname: Crémers
authors.forename: E
authors.initials: E
authors.lastname: Skawiniak
authors.forename: E
authors.initials: E
authors.lastname: Parmentier
authors.forename: V
authors.initials: V
authors.lastname: Delvaux
authors.forename: G
authors.initials: G
authors.lastname: Garraux
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D015259:Dopamine Agents / Q000009:adverse effects*; D006801:Humans
chemical_list: D000978:Antiparkinson Agents; D015259:Dopamine Agents