title: Coronary flow reserve from mouse to man--from mechanistic understanding to future interventions.
abstract: Myocardial ischemia is recognized as an important mechanism increasing the risk for cardiovascular events in both symptomatic and asymptomatic patients. In addition to obstructive coronary diseases, systemic inflammation, macro- and microvascular function are additional important mechanisms contributing to the ischemic myocardium. Accumulating evidence indicates that coronary flow reserve (CFR) is a quantitative measurement of ischemia including integrated information on structure and function of the coronary artery at all levels. Not surprisingly, CFR has been shown to confer strong prognostic value for hard cardiovascular (CV) events in a number of relevant patient cohorts. Using high-resolution imaging, it is now possible to study coronary arteries from mouse to man. Therefore, CFR may be an important translational tool to risk-stratify patients and to perform both preclinical and clinical proof-of-concept studies before investing in large-scale outcome trials, thus improving the translational value for novel CV targets.
authors.affiliation: Department of Molecular and Clinical Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Göteborg, Sweden, li-ming.gan@astrazeneca.com.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Gan
authors.forename: Johannes
authors.initials: J
authors.lastname: Wikström
authors.forename: Regina
authors.initials: R
authors.lastname: Fritsche-Danielson
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology*; D003952:Diagnostic Imaging / Q000379:methods; D004195:Disease Models, Animal; D053805:Fractional Flow Reserve, Myocardial / Q000187:drug effects; D006439:Hemodynamics; D006801:Humans; D051379:Mice; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D002317:Cardiovascular Agents