title: Segmentation of the striatum from MR brain images to calculate the 99mTc-TRODAT-1 binding ratio in SPECT images.
abstract: Quantification of regional (99m)Tc-TRODAT-1 binding ratio in the striatum regions in SPECT images is essential for differential diagnosis between Alzheimer's and Parkinson's diseases. Defining the region of the striatum in the SPECT image is the first step toward success in the quantification of the TRODAT-1 binding ratio. However, because SPECT images reveal insufficient information regarding the anatomical structure of the brain, correct delineation of the striatum directly from the SPECT image is almost impossible. We present a method integrating the active contour model and the hybrid registration technique to extract regions from MR T1-weighted images and map them into the corresponding SPECT images. Results from three normal subjects suggest that the segmentation accuracy using the proposed method was compatible with the expert decision but has a higher efficiency and reproducibility than manual delineation. The binding ratio derived by this method correlated well (R (2) = 0.76) with those values calculated by commercial software, suggesting the feasibility of the proposed method.
authors.affiliation: Department of Biomedical Engineering, I-Shou University, Kaohsiung 82445, Taiwan. cfjiang@isu.edu.tw
authors.forename: Ching-Fen
authors.initials: CF
authors.lastname: Jiang
authors.forename: Chiung-Chih
authors.initials: CC
authors.lastname: Chang
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Huang
authors.forename: Chia-Hsiang
authors.initials: CH
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D019295:Computational Biology; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000473:pathology*; D003936:Diagnosis, Computer-Assisted / Q000706:statistics & numerical data; D005103:Expert Systems; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D015609:Organotechnetium Compounds; D010300:Parkinson Disease / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D011857:Radiographic Image Interpretation, Computer-Assisted; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000706:statistics & numerical data*; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data; D014326:Tropanes
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1