title: Temporal changes of adiponectin plasma levels in patients with acute ischemic stroke.
abstract: Adiponectin, an adipocyte-derived hormone, possesses anti-inflammatory properties. Its decreased levels were noted in patients with ischemic stroke (IS). Animal studies suggest that the decline of adiponectin levels in the acute IS phase is a dynamic process. The aim of the present study was to analyze the temporal expression of the adiponectin plasma levels in patients with acute IS. Thirty-one consecutive patients with first-ever IS (mean age ± SD: 69.5 ± 12.5 years; 12 women) and 26 control subjects (CS; 72.2 ± 7.6 years; 18 women) were included into the study. Plasma adiponectin levels were measured at three time points: within first 24 hours, on Days 2-4, and on Days 5-10 days after the onset of IS. Adiponectin levels were significantly lower in IS patients on admission comparing with CS (medians: 6.0 μg/ml vs. 11.3 μg/ml, respectively; P < 0.05) and continued to decline at later time points (P < 0.001).
authors.affiliation: Jagiellonian University Medical College, ul. Botaniczna 3, Krakow, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Pera
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dziedzic
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szczudlik
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Slowik
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015992:Body Mass Index; D002545:Brain Ischemia / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012727:Sex Characteristics; D020521:Stroke / Q000097:blood*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D014280:Triglycerides