title: Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study.
abstract: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (eGFR <60 ml/min/1.73 m(2)). When those with CAT C-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% CI 0.43-1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
authors.affiliation: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumi-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Asahi
authors.initials: A
authors.lastname: Hishida
authors.forename: Rieko
authors.initials: R
authors.lastname: Okada
authors.forename: Mariko
authors.initials: M
authors.lastname: Naito
authors.forename: Emi
authors.initials: E
authors.lastname: Morita
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamajima
authors.forename: Satoyo
authors.initials: S
authors.lastname: Hosono
authors.forename: Hinako
authors.initials: H
authors.lastname: Nanri
authors.forename: Tanvir Chowdhury
authors.initials: TC
authors.lastname: Turin
authors.forename: Sadao
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Kuwabara
authors.forename: Haruo
authors.initials: H
authors.lastname: Mikami
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Budhathoki
authors.forename: Isao
authors.initials: I
authors.lastname: Watanabe
authors.forename: Kokichi
authors.initials: K
authors.lastname: Arisawa
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Hideo
authors.initials: H
authors.lastname: Tanaka
keywords: antioxidant enzymes; chronic kidney disease; genetic predisposition to disease; single nucleotide polymorphisms