title: Effect of an extra-virgin olive oil enriched with probiotics or antioxidants on functional dyspepsia: a pilot study.
abstract: BACKGROUND
  While antioxidants and probiotics have been proposed for the treatment of functional dyspepsia, current data are still heterogeneous and studies are poorly designed. Extra-virgin olive oil, a common ingredient of Mediterranean diet, has shown antioxidant properties.
  
  
  OBJECTIVE
  To evaluate the effect of extra-virgin olive oil enriched with antioxidants or probiotics on functional dyspepsia.
  
  
  METHODS
  This study has been designed as a "proof of concept". Extra-virgin olive oil enriched with antioxidants or probiotics was blindly added to the common diet of 8 subjects with functional dyspepsia for 7 days. Dyspeptic symptoms were then evaluated in all patients.
  
  
  CONCLUSIONS
  A significant improvement of dyspeptic symptoms was observed in subjects receiving the antioxidant or probiotic enriched oil diet, with a greater effect observed for the latter. Larger studies are now needed to confirm these data.
authors.affiliation: Department of Internal Medicine and Gastroenterology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy. studiogasbarrini@gasbarrini.it  
authors.forename: G
authors.initials: G
authors.lastname: Ianiro
authors.forename: M
authors.initials: M
authors.lastname: Pizzoferrato
authors.forename: F
authors.initials: F
authors.lastname: Franceschi
authors.forename: A
authors.initials: A
authors.lastname: Tarullo
authors.forename: T
authors.initials: T
authors.lastname: Luisi
authors.forename: G
authors.initials: G
authors.lastname: Gasbarrini
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use; D004415:Dyspepsia / Q000178:diet therapy*; D006801:Humans; D052200:Limosilactobacillus reuteri; D052201:Lacticaseibacillus rhamnosus; D000077276:Lycopene; D000069463:Olive Oil; D010865:Pilot Projects; D010938:Plant Oils / Q000627:therapeutic use*; D019936:Probiotics / Q000627:therapeutic use*; D000077185:Resveratrol; D012440:Saccharomyces; D012643:Selenium / Q000627:therapeutic use; D013267:Stilbenes / Q000627:therapeutic use; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D004042:Dietary Fats, Unsaturated; D000069463:Olive Oil; D010938:Plant Oils; D013267:Stilbenes; D014451:Ubiquinone; D002338:Carotenoids; C024989:coenzyme Q10; D012643:Selenium; D000077185:Resveratrol; D000077276:Lycopene