title: The role of cardiorenal biomarkers for risk stratification in the early follow-up after hospitalisation for acute heart failure.
abstract: BACKGROUND
  Cardiorenal biomarkers (CBs) predict outcome in acute heart failure (AHF).
  
  
  OBJECTIVE
  To evaluate CBs in early follow-up prognostication.
  
  
  METHODS
  In 124 AHF patients, levels of CystatinC, NT-proBNP and TroponinI measured five weeks from admission (W5) and relative change from day 2 (D2) were assessed for 6-month prognosis (mortality/HF hospitalization).
  
  
  RESULTS
  The combined end-point occurred in 33 patients (27%). D2-, W5-cystatin≥ median, and lack of ≥30%decrease in NT-proBNP were independent predictors of outcome. Additionally, a risk score established from W5 CBs identified patients with very high event rate.
  
  
  CONCLUSIONS
  CBs at early follow-up of AHF may guide risk stratification.
authors.affiliation: Department of Medicine and.
authors.forename: J
authors.initials: J
authors.lastname: Tolonen
authors.forename: J P E
authors.initials: JP
authors.lastname: Lassus
authors.forename: K
authors.initials: K
authors.lastname: Siirila-Waris
authors.forename: T
authors.initials: T
authors.lastname: Tarvasmäki
authors.forename: K
authors.initials: K
authors.lastname: Pulkki
authors.forename: R
authors.initials: R
authors.lastname: Sund
authors.forename: K
authors.initials: K
authors.lastname: Peuhkurinen
authors.forename: M S
authors.initials: MS
authors.lastname: Nieminen
authors.forename: V-P
authors.initials: VP
authors.lastname: Harjola
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006760:Hospitalization; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment
chemical_list: D015415:Biomarkers