title: Synthesis and spectroscopic characterization of 3,4-difluoroacetophenone-thiosemicarbazone and its palladium(II) complex: evaluation of antimicrobial and antitumour activity.
abstract: A new cis-palladium(II)diaqua(3,4-difluoroacetophenonethiosemicarbazone complex (Pd(II) complex) is synthesized using 3,4-difluoroacetophenonethiosemicarbazone(L). The L and its Pd(II) complex are characterized and confirmed by elemental analyses, electrochemical analyses, FT-IR, FT-Raman, UV-Vis, HRMS and LC-MS techniques. Ligand L is further characterized by (1)H, (13)C and (19)F NMR spectroscopy. The crystal structure of L is unambiguously characterized by single X-ray crystallography. The ligand (L) belongs to monoclinic system with P2(1)/C space group and the unit cell parameters are a(Å)=9.1144(7), b(Å)=13.7928(7), c(Å)=8.4174(5), α(°)=90, β(°)=100.715, γ(°)=90 and volume V(A(3))=1039.73(11). The Raman bands observed for the L and its Pd(II) complex are in good agreement with the FT-IR spectral data. The Pd(II) complex is found to be highly efficient in inhibiting the growth of human pathogens like Salmonella typhimurium and Klebsiella pneumonia with MIC value 10.0μg/mL whose inhibition zones are almost comparable with the standard antibiotic. The synthesized compounds have shown antiproliferative activity against the human breast cancer cell lines MDA-MB231 by intermitting the regular pathway of ribonucleotidereductase.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India.
authors.forename: M
authors.initials: M
authors.lastname: Jagadeesh
authors.forename: H K
authors.initials: HK
authors.lastname: Rashmi
authors.forename: Y
authors.initials: Y
authors.lastname: Subba Rao
authors.forename: A
authors.initials: A
authors.lastname: Sreenath Reddy
authors.forename: B
authors.initials: B
authors.lastname: Prathima
authors.forename: P
authors.initials: P
authors.lastname: Uma Maheswari Devi
authors.forename: A Varada
authors.initials: AV
authors.lastname: Reddy
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D055664:Electrochemical Techniques; D004583:Electrons; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010165:Palladium / Q000494:pharmacology*; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman
chemical_list: C586952:3,4-difluoroacetophenone-thiosemicarbazone; D000098:Acetophenones; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D012664:Semicarbazones; D010165:Palladium
keywords: Fluoro substituted thiosemicarbazone; Pd(II) complex; Raman spectra and Infrared spectroscopy