title: Palladium-catalyzed regioselective synthesis of 2(2'-biphenyl)benzimidazoles through C-H activation.
abstract: An efficient palladium-catalyzed strategy through C-H bond activation for the synthesis of 2(2[Formula: see text]-biphenyl)-benzimidazoles is reported herein. The regioselective C-C bond formation proceeds in a sealed tube via oxidative C-H activation of ortho-directed 2-aryl-benzimidazole to couple with various iodobenzene analogs in high yields. This arylation exhibited high regioselectivity which is able to increase molecular diversity in difficult functionalized positions of parent molecules. This strategy provides a convenient and simple synthesis of biphenyl heterocyclic compounds with high regioselectivity.
authors.affiliation: Laboratory of Combinatorial Drug Design, Department of Applied Chemistry, National Chiao Tung University, Hsin-chu, 300-10, Taiwan.
authors.forename: Li-Hsun
authors.initials: LH
authors.lastname: Chen
authors.forename: Tz-Yi
authors.initials: TY
authors.lastname: Wu
authors.forename: Vijaykumar
authors.initials: V
authors.lastname: Paike
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010165:Palladium / Q000737:chemistry*
chemical_list: D001562:Benzimidazoles; D010165:Palladium; C031000:benzimidazole