title: Reduction in choroidal thickness of macular area in polypoidal choroidal vasculopathy patients after intravitreal ranibizumab therapy.
abstract: BACKGROUND
  To evaluate changes in retinal and choroidal thickness changes after three intravitreal ranibizumab (IVR) injections for polypoidal choroidal vasculopathy (PCV) using enhanced depth-imaging-optical coherence tomography (EDI-OCT).
  
  
  METHODS
  In this retrospective, observational case series, EDI-OCT was used to measure changes in choroidal thickness at nine points in a lattice shape in the macula before and after introductory-stage IVR.
  
  
  RESULTS
  Choroidal thickness was decreased at all nine points in the lattice shape, but was significantly decreased only at the fovea.
  
  
  CONCLUSIONS
  The subfoveal choroidal thickness may be reduced by introductory-stage IVR in patients with PCV. In particular, choroidal thickness at the fovea was reduced during the early stage of treatment.
authors.affiliation: Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama-city, Kanagawa, Japan, 236-0004, nishide@abox3.so-net.ne.jp.
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Nishide
authors.forename: Natsuki
authors.initials: N
authors.lastname: Hayakawa
authors.forename: Misako
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Mai
authors.initials: M
authors.lastname: Ishii
authors.forename: Shinya
authors.initials: S
authors.lastname: Okazaki
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kimura
authors.forename: Etsuko
authors.initials: E
authors.lastname: Shibuya
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D002829:Choroid / Q000187:drug effects* / Q000473:pathology; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D008266:Macula Lutea; D008297:Male; D011127:Polyps / Q000175:diagnosis / Q000188:drug therapy*; D000069579:Ranibizumab; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000069579:Ranibizumab