title: Interval exercise training in cystic fibrosis -- effects on exercise capacity in severely affected adults.
abstract: The aims of the present study were to investigate the effects of IT on lung function power (P) and oxygen uptake (VO2) at peak performance (peak) and ventilatory anaerobic threshold (VAT) in CF patients who were unable to participate in a standard exercise program (SEP) and to compare these IT responses with corresponding effects in CF patients performing SEP. 20 patients (FEV1 25.5 ± 7.5%; pred; SpO2 < 90% at rest or P lower than 0.3 W/kg) who were unable to participate in SEP were allocated to IT (5 × 20 min weekly). 23 patients (FEV1 31.6 ± 4.2%; p < 0.05) did 5 × 45 min per week of SEP. Lung function remained unchanged in both groups. VO2peak and PVAT increased in both groups (p < 0.05). However, only after the SEP an increase in Ppeak (p < 0.05) and only after IT a higher VO2VAT (p < 0.05) were found. Compared to SEP, IT improved submaximal exercise capacity to a greater extent whereas responsiveness on peak performance was higher in SEP. This seems to indicate a specific potential of IT for positive peripheral muscular adaptations in spite of diminishing potential of pulmonary improvement. IT represents an alternative, effective and safe training regimen with patients with CF and severe lung disease, with a greater potential than SEP.
authors.affiliation: Institute for Sports and Exercise Medicine, University of Hamburg, Mollerstraße 10, 20148 Hamburg, Germany. Electronic address: gruber-wolfgang@t-online.de.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gruber
authors.affiliation: School of Medicine, School of Education, University of Pittsburgh, AOB 3rd floor, Suite 3300, Children's Hospital Drive, 45th and Penn, Pittsburgh, PA 15201, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Orenstein
authors.affiliation: Institute for Sports and Exercise Medicine, University of Hamburg, Mollerstraße 10, 20148 Hamburg, Germany.
authors.forename: Klaus M
authors.initials: KM
authors.lastname: Braumann
authors.affiliation: Department Medicine, Training and Health, University Marburg, Jahnstraße 12, 35032 Marburg, Germany.
authors.forename: Ralph
authors.initials: R
authors.lastname: Beneke
mesh_terms: D000293:Adolescent; D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D003550:Cystic Fibrosis / Q000503:physiopathology* / Q000534:rehabilitation*; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology; D005541:Forced Expiratory Volume; D006801:Humans; D010101:Oxygen Consumption / Q000502:physiology; D026741:Physical Therapy Modalities; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014797:Vital Capacity; D055815:Young Adult
keywords: Exercise capacity; Interval training; Responsiveness; Severely affected subjects