title: Silica coated gold nanorods for imaging and photo-thermal therapy of cancer cells.
abstract: Due to their efficient conversion of absorbed light energy to heat gold nanorods have been proved to be an amazing tool for minimally invasive photo-thermal cancer therapy. The present in vitro study demonstrates the ability of silica coated Au nanorods to function as a dual probe for cancer-cell therapy and imaging without any toxic side-effects. HeLa cells were incubated with silica coated Au nanorods and imaged inside the cell just after 1 hour of incubation by a dark field set up due to strong surface enhanced Raman scattering. To induce hyperthermia, silica coated Au nanorod incubated HeLa cells were illuminated with a diode laser (671 nm, 200 mW, 10 min). Cell destruction was observed even at a very low dose of nanorods, whereas none was observed in the absence of nanorods. Silica coated Au nanorods thus offer a promising, novel class of selective photo-thermal agents for cancer therapy and diagnosis.
authors.affiliation: Division of Bionanotechnology, GachonBionano Institute, Gachon University, Gyeonggi-do 461-701, South Korea.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Mallick
authors.forename: In-Cheol
authors.initials: IC
authors.lastname: Sun
authors.forename: Kwangmeyung
authors.initials: K
authors.lastname: Kim
authors.forename: Dong Kee
authors.initials: DK
authors.lastname: Yil
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000627:therapeutic use; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008027:Light; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000175:diagnosis* / Q000628:therapy*; D010316:Particle Size; D010789:Phototherapy / Q000379:methods; D012822:Silicon Dioxide / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D006046:Gold; D012822:Silicon Dioxide