title: An association between body mass index and high-sensitivity C-reactive protein concentrations is influenced by age in community-dwelling persons.
abstract: BACKGROUND
  High sensitivity C-reactive protein (hsCRP) is an acute phase reactant and a sensitive marker of inflammation. Age and adiposity can potentially promote the production of C-reactive protein (CRP). However, only a few studies have investigated any interaction between age and adiposity on hsCRP concentrations.
  
  
  METHODS
  We recruited 822 men (mean age, 61 ± 14 years) and 1097 women (63 ± 12 years) during their annual health examination from a single community. We cross-sectionally examined whether age, body mass index (BMI), and the interaction are significantly associated with hsCRP concentrations, independent of confounding factors.
  
  
  RESULTS
  Multiple linear regression analyses for hsCRP showed that in men, age (β = 0.169, P < 0.001) and BMI (β = 0.114, P = 0.004) as well as smoking status, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), uric acid, and gamma-glutamyl transferase (GGT) were significantly associated with hsCRP; and in women, age (β = 0.203, P < 0.001) and BMI (β = 0.225, P < 0.001) as well as HDL-C, fasting plasma glucose (FPG), uric acid, GGT and high-molecular weight adiponectin were significantly associated with hsCRP. In addition to their direct associations, the interaction between age and BMI was also a significant and independent determinant for hsCRP in both men (F = 4.407, P = 0.036) and women (F = 5.487, P = 0.019). In participants aged < 75 years, overweight (BMI ≥ 25.0 kg/m(2)) persons were more likely to have a prevalence of elevated hsCRP concentrations (≥ 1.00 mg/L) compared with the normal-weight (BMI <22.0 kg/m(2)), but such an association was not observed in those aged ≥ 75 years.
  
  
  CONCLUSIONS
  Adiposity promotes low-grade systemic inflammation in community-dwelling persons aged <75 years.
authors.affiliation: Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. rykawamo@m.ehim-u.ac.jp
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawamoto
authors.forename: Tomo
authors.initials: T
authors.lastname: Kusunoki
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
mesh_terms: D050154:Adiposity; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D007564:Japan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D012424:Rural Population; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D014527:Uric Acid; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase
keywords: C-reactive protein; age; body mass index; gender; interaction