title: Efficacy of aprotinin treatment on bilateral blunt chest trauma created in rabbits.
abstract: OBJECTIVE
  To investigate the effects of aprotinin, on blood gasses, oxidant-antioxidant status, and lung histopathology in an experimental bilateral blunt chest trauma model.
  
  
  METHODS
  Conducted at the Experimental Animal Laboratory of Meram Medical School at Selcuk University, Konya, Turkey, the study comprised 21 New Zealand female albino rabbits who were divided into three groups.Trauma was applied on the sham and aprotinin groups, which was administered intravenous Aprotinin 20.000 U/kg. Arterial blood samples were obtained from all rabbits at hours 0, 3, 24, and 96. At hour 96 after trauma, all rabbits were sacrificed using the decapitation method, and then blood and lung tissue samples were obtained. Blood nitric oxide, malondialdehyde and blood gas measurements were made. Histopathological changes in the lung were examined with a light microscope.
  
  
  RESULTS
  While no positive effect of aprotinin was observed on nitric oxide malondialdehyde and partial pressure of carbon dioxide values, it was seen to have an increasing effect on partial oxygen pressure level. Aprotinin had a partial effect on lung histopathology.
  
  
  CONCLUSIONS
  Aprotinin was determined to have a positive effect on PO2 levels. We could not find any positive effects especially on alveolar haemorrhage.
authors.affiliation: Department of Emergency Medicine, Harran University, Faculty of Medicine, Sanliurfa, Turkey, drhalilkaya@gmail.com
authors.forename: Halil
authors.initials: H
authors.lastname: Kaya
authors.forename: Mehmet Ertugrul
authors.initials: ME
authors.lastname: Kafali
authors.forename: Kemal
authors.initials: K
authors.lastname: Aydin
authors.forename: Sedat
authors.initials: S
authors.lastname: Kocak
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.forename: Arif
authors.initials: A
authors.lastname: Duran
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.forename: Basar
authors.initials: B
authors.lastname: Cander
authors.forename: Hatice
authors.initials: H
authors.lastname: Toy
authors.forename: Sami
authors.initials: S
authors.lastname: Erdem
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use*; D011817:Rabbits; D013898:Thoracic Injuries / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014949:Wounds, Nonpenetrating / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
chemical_list: D006490:Hemostatics; D007611:Aprotinin