title: Circadian Disruption: comparing humans with mice.
abstract: Disruption of the 24-h light-dark cycle has been implicated as an endocrine disruptor and linked to increased morbidity and mortality in animal studies. Previously reported measurements of circadian disruption in day-shift and rotating-shift nurses were compared with new mouse data where the light-dark patterns simulated shiftwork. Phasor magnitudes, a measure of circadian entrainment, were shown to be similar for humans and for mice when exposed to similar patterns of light and dark. Phasor analyses may be a useful method for quantitatively bridging ecological measurements of circadian disruption in human with parametric studies of health outcomes in a mouse model.
authors.affiliation: Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
authors.forename: Leora C
authors.initials: LC
authors.lastname: Radetsky
authors.forename: Mark S
authors.initials: MS
authors.lastname: Rea
authors.forename: Andrew
authors.initials: A
authors.lastname: Bierman
authors.forename: Mariana G
authors.initials: MG
authors.lastname: Figueiro
mesh_terms: D000818:Animals; D021081:Chronobiology Disorders / Q000503:physiopathology* / Q000523:psychology; D002940:Circadian Rhythm; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009726:Nurses / Q000523:psychology; D017440:Photoperiod; D012890:Sleep; D020178:Sleep Disorders, Circadian Rhythm / Q000503:physiopathology / Q000523:psychology; D013045:Species Specificity; D013493:Suprachiasmatic Nucleus / Q000503:physiopathology; D013997:Time Factors; D014940:Work Schedule Tolerance; D016526:Workload