title: Synthesis of 6-Se-guanosine RNAs for structural study.
abstract: 6-Se-guanosine phosphoramidite and RNAs have been synthesized by selenium substitution of the 6-oxygen atom, and it is revealed that the Se-derivatization is relatively stable and that bulge and wobble structures can better accommodate a large Se atom than a duplex. This Se-modification is useful in the structural study of RNAs and their protein complexes.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.
authors.forename: Jozef
authors.initials: J
authors.lastname: Salon
authors.forename: Jianhua
authors.initials: J
authors.lastname: Gan
authors.forename: Rob
authors.initials: R
authors.lastname: Abdur
authors.forename: Hehua
authors.initials: H
authors.lastname: Liu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
mesh_terms: D018360:Crystallography, X-Ray; D006151:Guanosine / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D012643:Selenium / Q000737:chemistry*
chemical_list: D016566:Organoselenium Compounds; D006151:Guanosine; D012313:RNA; D012643:Selenium