title: Simultaneous presentation of Kaposi sarcoma and HHV8-associated large B-cell lymphoma in the same lymph node: A rare diagnosis in an HIV-negative patient.
abstract: METHODS
  Female, 18 FINAL DIAGNOSIS: Simultanous presentation of Kaposi Sarcoma and Lymphoma Symptoms: -
  
  
  METHODS
  - Clinical Procedure: - Specialty: Oncology.
  
  
  OBJECTIVE
  Rare disease.
  
  
  BACKGROUND
  KSHV/HHV-8 is associated with Kaposi's sarcoma (KS) as well as with a few categories of lymphoproliferative diseases, mostly occurring in patients with HIV infection/AIDS. Although the association between lymphomas and Kaposi's sarcoma has been described, the simultaneous presence of the 2 entities within the same organ is rare and mainly associated with HIV/ AIDS.
  
  
  METHODS
  We report a case of simultaneous occurrence of Kaposi's sarcoma and large B-cell lymphoma in the same lymph node in a 18-year-old African woman who was HIV-negative. We found concurrent infection with Kaposi's sarcoma herpes virus (KSHV) and Epstein-Barr virus (EBV), confirmed by PCR amplification of DNA obtained from distinct tumor areas selected in the paraffin block.
  
  
  CONCLUSIONS
  The possibility of occurrence of 2 lesions with distinct features in the same organ may be unexpected for pathologists performing fine-needle aspiration cytology (FNAC) evaluation but must be considered, even in HIV-negative individuals, despite its rare occurrence, as was demonstrated by this case.
authors.affiliation: Department of Pathology, Faculty of Medicine of Eduardo Mondlane University and Hospital Central de Maputo, Maputo, Mozambique.
authors.forename: Fabíola
authors.initials: F
authors.lastname: Fernandes
authors.forename: Catarina
authors.initials: C
authors.lastname: Eloy
authors.forename: Awa
authors.initials: A
authors.lastname: Carimo
authors.forename: Paula
authors.initials: P
authors.lastname: Pinto
authors.forename: Susannah
authors.initials: S
authors.lastname: Graves
authors.forename: Joana
authors.initials: J
authors.lastname: Simões
authors.forename: Carla
authors.initials: C
authors.lastname: Carrilho
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Lopes
keywords: EBV; FNAC; HHV8; Kaposi’s sarcoma; large B-cell lymphoma; lymph node