title: Evaluation of a panel of expert pathologists: review of the diagnosis and histological classification of Hodgkin and non-Hodgkin lymphomas in a population-based cancer registry.
abstract: Abstract Correct histological classification of malignant lymphomas is important but has always been a difficult challenge. Since 2001 the World Health Organization (WHO) classification has been used, which should make it easier to define distinct disease entities. The purpose of this study was to evaluate the usefulness of a panel of expert hematopathologists in reviewing the diagnosis of malignant lymphomas and to examine whether the discordance between primary and panel diagnoses has declined throughout the years. All patients with a primary malignant lymphoma diagnosed between 2000-2001 and 2005-2006 were identified through the population based cancer registry. All diagnoses were reviewed by a panel of three expert pathologists. In 2000-2001, 344 patients were included, and in 2005-2006, 370 patients. The overall discordance rate decreased from 14% in 2000-2001 to 9% in 2005-2006 (p = 0.06). We were able to identify lymphoma subgroups with the highest discordance rates and lowest discordance rates (mantle cell lymphoma and classical Hodgkin lymphoma), which remained unchanged throughout the years. Based on these results we would propose to review all cases of malignant lymphoma with the exception of mantle cell lymphoma and classical Hodgkin lymphoma, when the initial pathologist has no doubt about the diagnosis.
authors.affiliation: Department of Medical Oncology.
authors.forename: Leonie
authors.initials: L
authors.lastname: Strobbe
authors.forename: Saskia A M
authors.initials: SA
authors.lastname: van der Schans
authors.forename: Sanneke
authors.initials: S
authors.lastname: Heijker
authors.forename: Jos W R
authors.initials: JW
authors.lastname: Meijer
authors.forename: E J M Vera
authors.initials: EJ
authors.lastname: Mattijssen
authors.forename: Carolien M P W
authors.initials: CM
authors.lastname: Mandigers
authors.forename: Ineke M
authors.initials: IM
authors.lastname: de Kievit
authors.forename: John M M
authors.initials: JM
authors.lastname: Raemaekers
authors.forename: Konnie M
authors.initials: KM
authors.lastname: Hebeda
authors.forename: J Han J M
authors.initials: JH
authors.lastname: van Krieken
mesh_terms: D005104:Expert Testimony; D006689:Hodgkin Disease / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000473:pathology*; D060787:Neoplasm Grading / Q000592:standards; D009426:Netherlands; D012042:Registries; D015203:Reproducibility of Results