title: Effect of a high bicarbonate mineral water on fasting and postprandial lipemia in moderately hypercholesterolemic subjects: a pilot study.
abstract: BACKGROUND
  During postprandial state, TG concentration is increasing and HDL cholesterol decreasing, leading to a transitory pro-atherosclerotic profile. Previous studies have reported that bicarbonate water improve postprandial lipemia. The objective of this study was to analyze the effect of a strongly bicarbonated mineral water on lipoprotein levels during fasting and postprandial state.
  
  
  METHODS
  A controlled, randomised, double-blind cross-over design was conducted in 12 moderately hypercholesterolemic subjects after a daily ingestion of 1.25 L of mineral (SY) or low mineral water during eight weeks separated by a one week wash-out period. Blood samples were collected in first visit to the hospital (V1) before water consumption (referent or SY) and in a second visit (V2) after eight week water consumption period. The effect of the consumed water was studied in fasting and in postprandial state during ingestion of a meal and 0.5 L of water.
  
  
  RESULTS
  Comparison of data between V1 and V2 after SY consumption showed a significant decrease in triglyceridemia (23%), VLDL TG (31%) and tendency to a decrease of VLDL cholesterol (p = 0.066) at fasting state. Whatever the consumed water during postprandial state, the measurement of total areas under curves did not show a significant difference. No difference was observed between SY and referent water consumption for measured parameters at fasting and postprandial state.
  
  
  CONCLUSIONS
  When subjects consumed SY we showed a decrease of their basal TG and VLDLTG. The unexpected absence of effect of high mineralized water on postprandial lipemia, probably related to experimental conditions, is discussed in the discussion section.
authors.forename: Yassine
authors.initials: Y
authors.lastname: Zair
authors.forename: Fatima
authors.initials: F
authors.lastname: Kasbi-Chadli
authors.forename: Beatrice
authors.initials: B
authors.lastname: Housez
authors.forename: Mathieu
authors.initials: M
authors.lastname: Pichelin
authors.forename: Murielle
authors.initials: M
authors.lastname: Cazaubiel
authors.forename: François
authors.initials: F
authors.lastname: Raoux
authors.forename: Khadija
authors.initials: K
authors.lastname: Ouguerram
mesh_terms: D000328:Adult; D001639:Bicarbonates / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005215:Fasting / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters; D010865:Pilot Projects; D019518:Postprandial Period / Q000187:drug effects*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001639:Bicarbonates; D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D008055:Lipids; D008900:Mineral Waters; D014280:Triglycerides