title: Heart failure in a woman with SLE, anti-phospholipid syndrome and Fabry's disease.
abstract: We describe a female patient with systemic lupus erythematosus (SLE) also diagnosed with Fabry's disease and anti-phospholipid antibody syndrome (APS). SLE and Fabry's disease are both systemic diseases with variable clinical presentations. Recent studies have shown a relatively high incidence of late onset Fabry's disease in female heterozygous individuals, suggesting that this condition could be under-diagnosed. We discuss a possible association between SLE and Fabry's disease and consider the role of lipid abnormalities in the pathogenesis of SLE.
authors.affiliation: Department of Rheumatology, University College Hospital, UK.
authors.forename: A
authors.initials: A
authors.lastname: Nandagudi
authors.forename: E C
authors.initials: EC
authors.lastname: Jury
authors.forename: D
authors.initials: D
authors.lastname: Alonzi
authors.forename: T D
authors.initials: TD
authors.lastname: Butters
authors.forename: S
authors.initials: S
authors.lastname: Hughes
authors.forename: D A
authors.initials: DA
authors.lastname: Isenberg
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D003937:Diagnosis, Differential; D000795:Fabry Disease / Q000150:complications*; D005260:Female; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000209:etiology
keywords: Fabry’s disease; Gb3; SLE