title: [Value of intermittent androgen deprivation in the context of the current data situation].
abstract: Androgen deprivation therapy is an integral part of the treatment of advanced and progressive prostate cancer. Various prospective randomised trials have investigated whether or not temporary suspension of androgen deprivation might delay the emergence of castration resistant prostate cancer and concomitantly improve quality of life. Until now, no phase III trial has been able to prove that intermittent androgen deprivation might delay the development of castration resistant tumours. Data from previous trials, except for one study, did at least not show adverse effects on survival. Data on quality of life are inconsistent, showing a trend towards improved quality of life with IAD. German as well as European guidelines reflect IAD as an established constituent of day-to-day medical practice. This review is intended to provide a code of practice for an individualised treatment as based on recently published studies.
authors.affiliation: Urologische Klinik, Charité, Berlin. kurt.miller@charite.de
authors.forename: K
authors.initials: K
authors.lastname: Miller
authors.forename: P
authors.initials: P
authors.lastname: Hammerer
authors.forename: R
authors.initials: R
authors.lastname: Eichenauer
authors.forename: G
authors.initials: G
authors.lastname: Geiges
authors.forename: J
authors.initials: J
authors.lastname: Lehmann
authors.forename: G
authors.initials: G
authors.lastname: Rodemer
authors.forename: C
authors.initials: C
authors.lastname: Ruessel
authors.forename: W
authors.initials: W
authors.lastname: Rulf
authors.forename: H
authors.initials: H
authors.lastname: Suttmann
authors.forename: J M
authors.initials: JM
authors.lastname: Wolff
mesh_terms: D000726:Androgen Antagonists / Q000008:administration & dosage*; D018450:Disease Progression; D004334:Drug Administration Schedule; D005858:Germany; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D064129:Prostatic Neoplasms, Castration-Resistant / Q000517:prevention & control; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis
chemical_list: D000726:Androgen Antagonists