title: Association of hepatic lipase -514T allele with coronary artery disease and ankle-brachial index, dependence on the lipoprotein phenotype: the GENES study.
abstract: OBJECTIVE
  Relationship between hepatic lipase (LIPC) polymorphism and coronary artery disease (CAD) has often led to contradictory results. We studied this relation by genotyping rs1800588 in the LIPC promoter in a case-control study on CAD (the GENES study). We also investigated the relationship between this polymorphism and the ankle-brachial index (ABI), which is predictive of atherosclerosis progression and complications in patients at high cardiovascular risk.
  
  
  METHODS
  557 men aged 45-74 with stable coronary artery disease and 560 paired controls were genotyped for rs1800588. Medical data, clinical examination including determination of ABI and biological measurements related to cardiovascular risk factors enabled multivariate analyses and multiple adjustments.
  
  
  RESULTS
  CAD cases showed a higher T-allele frequency than controls (0.246 vs 0.192, p = 0.003). An interaction has been found between LIPC polymorphism and triglycerides (TG) levels regarding risk of CAD: TT-homozigosity was associated with an Odds ratio (OR) of 6.4 (CI: 1.8-22.3) when TG were below 1.5 g/L, but no association was found at higher TG levels (OR = 1.34, CI: 0.3-5.9). The distribution of LIPC genotypes was compared between CAD patients with normal or abnormal ABI and impact of LIPC polymorphism on ABI was determined. Following multiple adjustments, association of the T-allele with pejorative ABI (<0.90) was significant for heterozygotes and for all T-carriers (OR = 1.55, CI: 1.07-2.25).
  
  
  CONCLUSIONS
  The -514T LIPC allele is associated with CAD under normotriglyceridemic conditions and constitutes an independent determinant of pejorative ABI in coronary patients.
authors.affiliation: CHU Toulouse, Department of Biochemistry, Toulouse, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Verdier
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Ruidavets
authors.forename: Vanina
authors.initials: V
authors.lastname: Bongard
authors.forename: Dorota
authors.initials: D
authors.lastname: Taraszkiewicz
authors.forename: Laurent O
authors.initials: LO
authors.lastname: Martinez
authors.forename: Meyer
authors.initials: M
authors.lastname: Elbaz
authors.forename: Jean
authors.initials: J
authors.lastname: Ferrières
authors.forename: Bertrand
authors.initials: B
authors.lastname: Perret
mesh_terms: D000368:Aged; D000483:Alleles; D055109:Ankle Brachial Index; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008049:Lipase / Q000235:genetics*; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C504173:LIPC protein, human; D008074:Lipoproteins; D008049:Lipase