title: A case report of long-term bisphosphonate therapy and atypical stress fracture of bilateral femur.
abstract: Bisphosphonates are potent inhibitors of bone resorption and considered as a gold standard and are generally recommended as first-line therapy in patients with osteoporosis. Though bisphosphonates are shown to significantly reduce the risk of vertebral, non-vertebral and hip fractures, recent reports suggest a possible correlation between long-term bisphosphonate therapy and the occurrence of insufficiency fractures owing to prolonged bone turnover suppression. We report a patient with non-traumatic stress fractures of bilateral femoral shafts related to long-term bisphosphonate therapy indicating the need for a critical evaluation of patients with long-term bisphosphonate therapy.
authors.affiliation: Department of Rehabilitation Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Yil Ryun
authors.initials: YR
authors.lastname: Jo
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Seock Ho
authors.initials: SH
authors.lastname: Moon
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Ko
keywords: Bisphosphonates; Osteoporosis; Stress fracture