title: Four new diterpenes from Aphanamixis polystachya.
abstract: Four novel diterpenes possessing rare five-membered peroxide ring, aphanaperoxides E-H (1-4), were isolated from stem bark of Aphanamixis polystachya. Their structures including the absolute configuration were elucidated by spectroscopic data and CD analysis. The cytotoxicities of the isolated compounds against a panel of human cancer cell lines were evaluated.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.forename: Xiao-Po
authors.initials: XP
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Zhang
authors.forename: Guo-Xu
authors.initials: GX
authors.lastname: Ma
authors.forename: Yu
authors.initials: Y
authors.lastname: Tian
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Wu
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Chen
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
mesh_terms: D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D009369:Neoplasms; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems
chemical_list: D004224:Diterpenes; D010936:Plant Extracts
keywords: Aphanamixis polystachya; Cytotoxicity; Diterpenes