title: Genes alternations with exposure time of environmental factors.
abstract: A theoretical model discussing the environmental factors (EFs) effect of exposure time on genes, which leads to human diseases, is presented using multi-logistic model. The advantages and limitations of this model are discussed in terms of its usefulness for simulating genetic samples. It has been shown that EFs affect genes with the same degree both at high exposure level, low exposure time and at low exposure level, high exposure time.
authors.affiliation: Department of Physics, Faculty of Science, King Abdulaziz University Jeddah, P.O. Box 80203, Jeddah 21589, Saudi Arabia. smabdullah@kau.edu.sa
authors.forename: S
authors.initials: S
authors.lastname: Abdalla
authors.forename: Y
authors.initials: Y
authors.lastname: Al-Hadeethi
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004781:Environmental Exposure; D059647:Gene-Environment Interaction; D005796:Genes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013997:Time Factors
keywords: ADD; EFs; ENV; Environmental factors; Exposure level; Exposure time; GEM; GEN; Genetics; MLM; Model and simulation; P((ga, gb)); R(g(a), g(b)); additive effect; biological life period of the individual; dimensionless time-factor; environmental effect; environmental factors; free parameter concern the individual himself; genetic effect; modulative effect; multi-logistic model; period of exposure time; the probability for an individual to carry the genotype; time-factor; total risk for each genotype (g(a), g(b)); u; u(EFs); u(i); τ(EFs); τ(i)