title: Effect of omega-3 dietary supplements with different oxidation levels in the lipidic profile of women: a randomized controlled trial.
abstract: The oxidation level of omega-3 fatty acid supplements commercialized in capsules may be a risk to consumers' health. For this purpose, we have designed a single-blind, parallel-group, randomized controlled trial in which 52 women participated. Volunteers were randomly distributed into three groups consuming: (1) less oxidized oil pills, (2) highly oxidized oil pills and (3) no capsules. All groups consumed a fish-rich diet. Circulating glucose, total cholesterol, triglycerides and glutamic pyruvic transaminase were determined at the beginning and end (30 days) of the study. As a result, the ingestion of less oxidized ω-3 supplements reduced circulating triglyceride and cholesterol levels, as opposed to the highly oxidized omega-3 capsules, which had a negative effect on cholesterol levels. In conclusion, the level of oxidation of the supplements is a key factor in controlling circulating lipid profile. Therefore, manufacturers must pay attention to the quality of the prime product prior to encapsulation.
authors.affiliation: Department of Applied Biology-Nutrition and Institute of Bioengineering, Miguel Hernandez University , Elche, Alicante , Spain .
authors.forename: V M
authors.initials: VM
authors.lastname: García-Hernández
authors.forename: M
authors.initials: M
authors.lastname: Gallar
authors.forename: J
authors.initials: J
authors.lastname: Sánchez-Soriano
authors.forename: V
authors.initials: V
authors.lastname: Micol
authors.forename: E
authors.initials: E
authors.lastname: Roche
authors.forename: E
authors.initials: E
authors.lastname: García-García
mesh_terms: D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D004032:Diet; D004041:Dietary Fats / Q000378:metabolism / Q000494:pharmacology*; D019587:Dietary Supplements / Q000592:standards*; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D010084:Oxidation-Reduction; D017747:Seafood; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood*
chemical_list: D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D014280:Triglycerides; D002784:Cholesterol