title: Relationship of olfactory function with olfactory bulbus volume, disease duration and Unified Parkinson's disease rating scale scores in patients with early stage of idiopathic Parkinson's disease.
abstract: We aimed to investigate the relationship between olfactory function and olfactory bulbus (OB) volume, disease duration and Unified Parkinson's disease rating scale (UPDRS) scores in early stage idiopathic Parkinson's disease patients. The University of Pennsylvania Smell Identification Test (UPSIT) was used for the evaluation of olfactory function. UPSIT scores for patients with Parkinson's disease were significantly lower than controls. There was no significant difference between stage 1 and stage 2 patients. OB volumes were higher in stage 1 and 2 patients than controls, but there was no statistical difference between the three groups. No significant correlation was found between UPSIT and UPDRS total scores, nor between UPSIT scores and disease duration in stage 1 and 2 patients. According to our results, we propose UPSIT be used as a screening test to diagnose presymptomatic patients, but not OB volumes.
authors.affiliation: Haseki Training and Research Hospital, Department of Neurology, Istanbul, Turkey.
authors.forename: Hüsniye Aylin
authors.initials: HA
authors.lastname: Hakyemez
authors.forename: Bayram
authors.initials: B
authors.lastname: Veyseller
authors.forename: Feriha
authors.initials: F
authors.lastname: Ozer
authors.forename: Serkan
authors.initials: S
authors.lastname: Ozben
authors.forename: Gulum Ivgin
authors.initials: GI
authors.lastname: Bayraktar
authors.forename: Defne
authors.initials: D
authors.lastname: Gurbuz
authors.forename: Sibel
authors.initials: S
authors.lastname: Cetin
authors.forename: Yavuz Selim
authors.initials: YS
authors.lastname: Yildirim
mesh_terms: D000368:Aged; D018450:Disease Progression; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000209:etiology*; D009830:Olfactory Bulb / Q000473:pathology*; D010300:Parkinson Disease / Q000150:complications*; D012720:Severity of Illness Index
keywords: Idiopathic Parkinson’s disease; Olfactory bulbus volume; Olfactory function