title: Progress in mapping the yellow fever mosquito genome.
abstract: Mosquito-borne diseases cause significant problems for the human health. For this reason, the genomes of three most dangerous species of mosquitoes, including the yellow fever mosquito Aedes aegypti, were sequenced in last decade. The efficient vector of arboviruses. Ae. aegypti, is also a convenient model for laboratory research. The intensive genetic mapping of morphological and molecular markers conducted for this mosquito in the past was very successful. This mapping was also used as a tool to localize a number of quantitative trait loci related to the mosquito's ability to transmit various pathogens. However, physical mapping of the Ae. aegypti genome is difficult due to the lack of high-quality polytene chromosomes. Here, we review different mapping approaches that help improving genome sequence assembly and also integrate linkage, chromocome and genome maps the yellow fever mosquito.
authors.affiliation: Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA. msharakh@vt.edu
authors.forename: M V
authors.initials: MV
authors.lastname: Sharakhova
authors.forename: I V
authors.initials: IV
authors.lastname: Sharakhov
mesh_terms: D000330:Aedes / Q000235:genetics* / Q000821:virology; D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D008040:Genetic Linkage; D005819:Genetic Markers; D049750:Genome, Insect; D006801:Humans; D007303:Insect Vectors / Q000235:genetics* / Q000821:virology; D040641:Quantitative Trait Loci; D015004:Yellow Fever / Q000635:transmission
chemical_list: D005819:Genetic Markers