title: Biocatalysts for cascade reaction: porcine pancreas lipase (PPL)-catalyzed synthesis of bis(indolyl)alkanes.
abstract: A cascade reaction between aldehydes and indole catalyzed by lipase from porcine pancreas Type II (PPL) in solvent mixture at 50 °C was reported for the first time. Some control experiments had been designed to demonstrate that the PPL was responsible for the cascade reaction. After the optimization of the stepwise process, a series of bis(indolyl)alkanes were prepared in moderate to excellent yields under the catalysis of PPL.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou, 310027, People's Republic of China.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Xiang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Wu
authors.forename: XianFu
authors.initials: X
authors.lastname: Lin
mesh_terms: D000473:Alkanes / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D055162:Biocatalysis; D007211:Indoles / Q000737:chemistry / Q000378:metabolism*; D008049:Lipase / Q000378:metabolism*; D015394:Molecular Structure; D010179:Pancreas / Q000201:enzymology*; D013552:Swine
chemical_list: D000473:Alkanes; D007211:Indoles; D008049:Lipase