title: Obesity, cancer, and acetyl-CoA metabolism.
abstract: As rates of obesity soar in the Unites States and around the world, cancer attributed to obesity has emerged as major threat to public health. The link between obesity and cancer can be attributed in part to the state of chronic inflammation that develops in obesity. Acetyl-CoA production and protein acetylation patterns are highly sensitive to metabolic state and are significantly altered in obesity. In this article, we explore the potential role of nutrient-sensitive lysine acetylation in regulating inflammatory processes in obesity-linked cancer.
authors.affiliation: Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
authors.forename: Joyce V
authors.initials: JV
authors.lastname: Lee
authors.forename: Supriya A
authors.initials: SA
authors.lastname: Shah
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Wellen