title: Characterization of heterotopic ossification in burn patients.
abstract: Heterotopic ossification (HO) is a clinical condition of ectopic bone formation in soft tissue. This clinical entity has been associated with genetic disorders, traumatic injuries, and musculoskeletal surgeries. In this regard, functional impairments secondary to scar contractures seen in burn injuries may be exacerbated with underlying HO. The appropriate prevention or management of this complication is crucial to optimize outcome in burn patients. This clinical study reviews the incidence of HO in our burned patients, diagnostic methods, therapeutic approaches including surgical timing and techniques.
authors.affiliation: From the *Wound Healing Research Group, Division of Plastic and Reconstructive Surgery, †Division of Critical Care Medicine, and ‡Firefighters' Burn Treatment Unit, Department of Surgery, University of Alberta, Edmonton, Canada.
authors.forename: Abelardo
authors.initials: A
authors.lastname: Medina
authors.forename: Heather
authors.initials: H
authors.lastname: Shankowsky
authors.forename: Bohdan
authors.initials: B
authors.lastname: Savaryn
authors.forename: Barb
authors.initials: B
authors.lastname: Shukalak
authors.forename: Edward E
authors.initials: EE
authors.lastname: Tredget
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000416:Alberta; D002053:Burn Units; D002056:Burns / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D012968:Etidronic Acid / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015994:Incidence; D015601:Injury Severity Score; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000379:methods; D009999:Ossification, Heterotopic / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy*; D011379:Prognosis; D016059:Range of Motion, Articular / Q000502:physiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D017678:Sex Distribution; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D012968:Etidronic Acid