title: Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine.
abstract: The aim of regenerative medicine is to restore or establish normal function of damaged tissues or organs. Tremendous efforts are placed into development of novel regenerative strategies, involving (stem) cells, soluble factors, biomaterials or combinations thereof, as a result of the growing need caused by continuous population aging. To satisfy this need, fast and reliable assessment of (biological) performance is sought, not only to select the potentially interesting candidates, but also to rule out poor ones at an early stage of development. Microfluidics may provide a new avenue to accelerate research and development in the field of regenerative medicine as it has proven its maturity for the realization of high-throughput screening platforms. In addition, microfluidic systems offer other advantages such as the possibility to create in vivo-like microenvironments. Besides the complexity of organs or tissues that need to be regenerated, regenerative medicine brings additional challenges of complex regeneration processes and strategies. The question therefore arises whether so much complexity can be integrated into microfluidic systems without compromising reliability and throughput of assays. With this review, we aim to investigate whether microfluidics can become widely applied in regenerative medicine research and/or strategies.
authors.affiliation: Department of Tissue Regeneration, MIRA Institute for Biomedical Engineering and Technical Medicine, PO Box 217, 7500AE Enschede, The Netherlands. bjornharink@gmail.com
authors.forename: Björn
authors.initials: B
authors.lastname: Harink
authors.forename: Séverine
authors.initials: S
authors.lastname: Le Gac
authors.forename: Roman
authors.initials: R
authors.lastname: Truckenmüller
authors.forename: Clemens
authors.initials: C
authors.lastname: van Blitterswijk
authors.forename: Pamela
authors.initials: P
authors.lastname: Habibovic
mesh_terms: D018929:Cell Culture Techniques / Q000295:instrumentation; D006801:Humans; D008115:Liver Regeneration; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D009416:Nerve Regeneration / Q000502:physiology; D012038:Regeneration; D044968:Regenerative Medicine; D023822:Tissue Engineering; D014945:Wound Healing