title: The nuclear envelope LEM-domain protein emerin.
abstract: Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease--is available. This review summarizes emerin and its emerging roles in nuclear "lamina" structure, chromatin tethering, gene regulation, mitosis, nuclear assembly, development, signaling and mechano-transduction. We also highlight many open questions, exploration of which will be critical to understand how this intriguing nuclear membrane protein and its "family" influence the genome.
authors.affiliation: Department of Cell Biology; Johns Hopkins University School of Medicine; Baltimore, MD USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Berk
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Tifft
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Wilson
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009685:Nuclear Envelope / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D009687:Nuclear Proteins; C092710:emerin
keywords: Emery-Dreifuss muscular dystrophy; GAGE cancer-testis antigen; LEM-domain; Nestor-Guillermo progeria; O-GlcNAc transferase; barrier-to-autointegration factor; emerin; laminopathy; nuclear envelope; nucleoskeleton