title: Iron(II)-catalyzed asymmetric intramolecular aminohydroxylation of indoles.
abstract: An enantioselective intramolecular indole aminohydroxylation reaction is catalyzed by iron(II)-chiral bisoxazoline (BOX) complexes (ee up to 99%, dr > 20:1). This discovery enables expedient asymmetric synthesis of a series of biologically active 3-amino oxindoles and 3-amino indolanes.
authors.affiliation: Department of Chemistry, Georgia State University, 100 Piedmont Avenue SE, Atlanta, Georgia 30303, USA.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Yong-An
authors.initials: YA
authors.lastname: Yuan
authors.forename: Guan-Sai
authors.initials: GS
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry*; D006900:Hydroxylation; D007211:Indoles / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: C551521:3-amino-2-oxindole; D005296:Ferrous Compounds; D007211:Indoles; D000078183:Oxindoles; D007501:Iron