title: Growing up in the genomic era: implications of whole-genome sequencing for children, families, and pediatric practice.
abstract: Whole-genome sequencing (WGS) has advanced to a point where it is beginning to be integrated into pediatric practice. With little consensus on how to maximize the benefits of WGS for children, there is a growing need for focused efforts that connect researchers, clinicians, and families to chart a path forward. To illustrate relevant concerns, two contrasting applications of pediatric WGS are explored: clinical use with children who have undiagnosed conditions, and population-based screening. Specific challenges for health care services, policy development, and the well-being of children are discussed in light of current research. In the interest of ensuring evidence-based pediatric WGS, strategies are identified for advancing our understanding of what it means for children to grow up with WGS results guiding their health care.
authors.affiliation: Nursing and Health Studies Program, University of Washington Bothell, Bothell, Washington 98011; email: cwade@uwb.edu.
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Wade
authors.forename: Beth A
authors.initials: BA
authors.lastname: Tarini
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Wilfond
mesh_terms: D002648:Child; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D010372:Pediatrics; D017422:Sequence Analysis, DNA