title: Carbon-core silver-shell nanodots as sensitizers for phototherapy and radiotherapy.
abstract: Spherical carbon nanoparticles (carbon nanodots) with a silver shell were investigated as potential sensitizing agents. The cytotoxicity of the combination of ultraviolet radiation or x-rays with the nanodots was examined in cancer cells in vitro. The cell viability decreased following the exposure to the radiation. The carbon nanodots enhanced the radiation effects by significantly reducing the amount of surviving cells compared to that of the cells exposed only to the radiation. Carbon-core silver-shell nanodots can be proposed as a bimodal sensitization platform for biological and medicinal applications employing non-ionizing or ionizing radiation.
authors.affiliation: Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello 0310 Oslo, Norway.
authors.forename: Andrius
authors.initials: A
authors.lastname: Kleinauskas
authors.forename: Sandra
authors.initials: S
authors.lastname: Rocha
authors.forename: Sushant
authors.initials: S
authors.lastname: Sahu
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Sun
authors.forename: Petras
authors.initials: P
authors.lastname: Juzenas
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis / Q000528:radiation effects; D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D057446:Hydrodynamics; D053758:Nanoparticles / Q000633:toxicity / Q000648:ultrastructure; D017319:Photosensitizing Agents / Q000494:pharmacology*; D010789:Phototherapy; D011878:Radiotherapy; D012834:Silver / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014466:Ultraviolet Rays
chemical_list: D017319:Photosensitizing Agents; D012834:Silver; D002244:Carbon