title: Anti-inflammatory and antinociceptive effects of hydroalcoholic extract from Pseudobombax marginatum inner bark from caatinga potiguar.
abstract: BACKGROUND
  The Pseudobombax marginatum (St Hil) Rob., Malvaceae, is mentioned in ethnobotanical studies. It is used as anti-inflammatory, for ulcers and gastritis, and back pain. To evaluate anti-inflammatory and antinociceptive activities a hydroalcoholic extract (HE) from inner bark was prepared.
  
  
  METHODS
  For the anti-inflammatory activity, carrageenan-induced paw edema and peritonitis models, and also myeloperoxidase assay were used. For the antinociceptiva activity acetic acid-induced writhing, hot plate and formalin tests were employed.
  
  
  RESULTS
  The HE extract exhibited an intense inhibition in carrageenan-induced edema model and also in myeloperoxidase activity at the doses of 100 and 300 mg/kg. The leukocyte migration into the peritoneal cavity was also inhibited at the doses of 30, 100 and 300 mg/kg. A similar profile was observed against acid-induced abdominal contortions and in formalin second phase test at the doses of 30 and 100 mg/kg, but this treatment did not affect the behavior of animals in the hot plate test.
  
  
  CONCLUSIONS
  The experimental data of the HE from Pseudobombax marginatum show anti-inflammatory and antinociceptiva activities, confirming the indication from traditional medicine; however further studies are required to define and isolate the active anti-inflammatory and antinociceptiva components from this active specie.
authors.affiliation: Universidade do Estado do Rio Grande do Norte, Mossoró/RN, Brazil.
authors.forename: Dayane Carla Costa
authors.initials: DC
authors.lastname: Paiva
authors.forename: Cliomar Alves
authors.initials: CA
authors.lastname: dos Santos
authors.forename: Jaécio Carlos
authors.initials: JC
authors.lastname: Diniz
authors.forename: Francisco Arnaldo
authors.initials: FA
authors.lastname: Viana
authors.forename: Sara Maria
authors.initials: SM
authors.lastname: Thomazzi
authors.forename: Dayseanne Araujo
authors.initials: DA
authors.lastname: Falcão
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D000431:Ethanol / Q000737:chemistry; D005557:Formaldehyde; D006358:Hot Temperature; D008297:Male; D019660:Malvaceae; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000627:therapeutic use*; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012997:Solvents; D005557:Formaldehyde; D000431:Ethanol; D002351:Carrageenan; D019342:Acetic Acid
keywords: ANOVA; APG; ASA; AUC; CEPA; COX; EDTA; FLONA; HE; Inflammation; MPO; NO; Nociception; PGE2; PGs; Pseudobombax marginatum; SISBIO; UMPO; acetylsalicylic acid; analysis of variance; area under curves; authorization system and information in biodiversity; cyclo-oxygenase; ethics committee for animal use in research; ethylenediaminetetraacetic acid; group phylogeny of angiosperms; hydroalcoholic extract; myeloperoxidase; national forest; nitric oxide; prostaglandin E2; prostaglandins; units of myeloperoxidase