title: A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells.
abstract: Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage-doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.
authors.affiliation: Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan.
authors.forename: Riki
authors.initials: R
authors.lastname: Toita
authors.forename: Masaharu
authors.initials: M
authors.lastname: Murata
authors.forename: Kana
authors.initials: K
authors.lastname: Abe
authors.forename: Sayoko
authors.initials: S
authors.lastname: Narahara
authors.forename: Jing Shu
authors.initials: JS
authors.lastname: Piao
authors.forename: Jeong-Hun
authors.initials: JH
authors.lastname: Kang
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashizume
mesh_terms: D000595:Amino Acid Sequence; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D019843:Archaeal Proteins / Q000737:chemistry* / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry; D050888:Heat-Shock Proteins, Small / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D063747:Methanocaldococcus / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry; D015202:Protein Engineering
chemical_list: D000903:Antibiotics, Antineoplastic; D019843:Archaeal Proteins; D004337:Drug Carriers; D050888:Heat-Shock Proteins, Small; D004317:Doxorubicin