title: Evaluation of cerebral electrical activity and cardiac output after patent ductus arteriosus ligation in preterm infants.
abstract: OBJECTIVE
  To characterize and investigate the relationship between systemic blood flow and pre- and postoperative cerebral electrical activity in preterm neonates undergoing patent ductus arteriosus (PDA) ligation.
  
  
  METHODS
  A prospective observational study was conducted in 17 preterm neonates undergoing PDA ligation. All infants had amplitude-integrated electroencephalography (aEEG) recorded continuously from 4 h preoperatively to 24 h postoperatively. Targeted neonatal echocardiography was performed to evaluate myocardial performance and systemic blood flow at four sequential time points: preoperatively; 1, 8 and 24 h postoperatively.
  
  
  RESULTS
  PDA ligation was followed by a fall in the lower border of the aEEG trace lower left ventricular output, but recovery of diastolic flow in the middle cerebral artery. Altered lower margin was associated with gestational age and PDA diameter on univariate analysis, but not with low cardiac output.
  
  
  CONCLUSIONS
  PDA ligation was associated with altered cerebral electrical activity, although these changes were not related to low cardiac output state.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: A T F S
authors.initials: AT
authors.lastname: Leslie
authors.forename: A
authors.initials: A
authors.lastname: Jain
authors.forename: A
authors.initials: A
authors.lastname: El-Khuffash
authors.forename: M
authors.initials: M
authors.lastname: Keyzers
authors.forename: S
authors.initials: S
authors.lastname: Rogerson
authors.forename: P J
authors.initials: PJ
authors.lastname: McNamara
mesh_terms: D001921:Brain / Q000503:physiopathology*; D002302:Cardiac Output; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology / Q000601:surgery*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005865:Gestational Age; D006801:Humans; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies