title: Expression and significance of MMP-7, c-Jun and c-Fos in rats skin photoaging.
abstract: OBJECTIVE
  To investigate the expression and significance of the MMP-7, c-Jun and c-Fos in rat photoaging skin.
  
  
  METHODS
  A total of 45 SD rats were randomly divided into control group, model group, natural recovery group, physiological saline injection group and dermal pluripotent stem cells transplantation (DMSCs group), model group, natural recovery group, physiological saline injection group. DMSCs were treated with UV lamp irradiation to establish light aging skin model. Rats were then sacrificed after model prepared, no treatment was processed in the natural recovery group. Saline injections was adopted in saline group, DESCs group was treated with DESCs transplantation. Rats were sacrificed after 4 weeks. The expression of MMP-7, c-Jun and c-Fos were detected using the immunohistochemical method.
  
  
  RESULTS
  In model group, MMP 7 positive expression was higher than that in the other 4 groups, but without statistically difference (P>0.05); c-Jun, c-Fos expression were higher than that in the control group and DESCs group (P<0.05), there was no significant difference comparing natural recovery group with physiological saline injection group (P>0.05).
  
  
  CONCLUSIONS
  MMP-7, c-Jun and c-Fos can be used as diagnosis indicators in the early stage of light aging, and they jointly participate in its development. DMSCs transplants is effective in treating light aging skin.
authors.affiliation: Department of Dermatology, Affiliated Hospital of Yan'an University, Yan'an 716000, Shaanxi Province, China.
authors.forename: Long-Quan
authors.initials: LQ
authors.lastname: Shi
authors.forename: Cai-Lian
authors.initials: CL
authors.lastname: Ruan
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D000818:Animals; D015870:Gene Expression / Q000528:radiation effects; D006801:Humans; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000235:genetics* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics* / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D020783:Matrix Metalloproteinase 7
keywords: Aging skin; Expression; MMP-7; c-Fos; c-Jun