title: [Association between MAOA-u VNTR polymorphism and its interaction with stressful life events and major depressive disorder in adolescents].
abstract: OBJECTIVE
  To investigate whether the genetic polymorphism, upstream variable number of tandem repeats (uVNTR), in the monoamine oxidase A (MAOA) gene, is associated with major depressive disorder (MDD) in adolescents and to test whether there is gene-environment interaction between MAOA-uVNTR polymorphism and stressful life events (SLEs).
  
  
  METHODS
  A total of 394 Chinese Han subjects, including 187 adolescent patients with MDD and 207 normal students as a control group, were included in the study. Genotyping was performed by SNaP-shot assay. SLEs in the previous 12 months were evaluated. The groups were compared in terms of the frequency distributions of MAOA-uVNTR genotypes and alleles using statistical software. The binary logistic regression model of gene-environment interaction was established to analyze the association of the gene-environment interaction between MAOA-u VNTR genotypes and SLEs with adolescent MDD.
  
  
  RESULTS
  The distribution profiles of MAOA-u VNTR genotypes and alleles were not related to the onset of MDD, severity of depression, comorbid anxiety and suicidal ideation/behavior/attempt in adolescents. The gene-environment interaction between MAOA-u VNTR genotypes and SLEs was not associated with MDD in male or female adolescents.
  
  
  CONCLUSIONS
  It is not proven that MAOA-u VNTR polymorphism is associated with adolescent MDD. There is also no gene-environment interaction between MAOA-u VNTR polymorphism and SLEs that is associated with adolescent MDD.
authors.affiliation: Department of Psychiatry, Second People's Hospital of Hunan Province, Changsha 410007, China. Child-psy8@yahoo.com.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Shun-Ying
authors.initials: SY
authors.lastname: Yu
authors.forename: Shan
authors.initials: S
authors.lastname: Liang
authors.forename: Jun
authors.initials: J
authors.lastname: Ding
authors.forename: Zhe
authors.initials: Z
authors.lastname: Feng
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Gao
authors.forename: Jia-Ni
authors.initials: JN
authors.lastname: Lin
authors.forename: Chun-Xiang
authors.initials: CX
authors.lastname: Huang
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Liu
authors.forename: Lin-Yan
authors.initials: LY
authors.lastname: Su
mesh_terms: D000293:Adolescent; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D016015:Logistic Models; D008297:Male; D018598:Minisatellite Repeats; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D008995:Monoamine Oxidase