title: Dancing the cell cycle two-step: regulation of yeast G1-cell-cycle genes by chromatin structure.
abstract: The chromatin structure at a promoter can define how a gene is regulated. Studies of two yeast genes expressed in the G1 phase of the cell cycle, HO and CLN2, have provided important paradigms for transcriptional regulation. Although the SBF (Swi4/Swi6 box factor) transcription factor activates both genes, the chromatin landscapes that regulate SBF binding are different. Specifically, the CLN2 promoter is constitutively available for SBF binding, whereas HO has a complex two-step promoter in which chromatin changes in one region allow SBF to bind at a downstream location. These studies reveal the role of chromatin in defining the regulatory properties of promoters.
authors.affiliation: Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA. david.stillman@path.utah.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Stillman
mesh_terms: D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D011401:Promoter Regions, Genetic / Q000235:genetics; D015003:Yeasts / Q000166:cytology* / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins
keywords: cell cycle; chromatin; gene activation; promoter