title: Self-assembled phytosterol-fructose-chitosan nanoparticles as a carrier of anticancer drug.
abstract: Self-assembled nanoparticles were synthesized from water-soluble fructose-chitosan, substituted by succinyl linkages with phytosterols as hydrophobic moieties for self-assembly. The physicochemical properties of the prepared self-assembled nanoparticles were characterized by Fourier transform infrared spectroscopy, fluorescence spectroscopy, and transmission electron microscopy. Doxorubicin (DOX), as a model anticancer drug, was physically entrapped inside prepared self-assembled nanoparticles by the dialysis method. With increasing initial levels of the drug, the drug loading content increased, but the encapsulation efficiency decreased. The release profiles in vitro demonstrated that the DOX showed slow sustained released over 48 h, and the release rate in phosphate buffered saline (PBS) solution (pH 7.4) was much slower than in PBS solution (pH 5.5 and pH 6.5), indicating the prepared self-assembled nanoparticles had the potential to be used as a carrier for targeted delivery of hydrophobic anticancer drugs with declined cytotoxicity to normal tissues.
authors.affiliation: College of Life Science, Anhui Normal University, Wuhu 241000, PR China.
authors.forename: Yeyan
authors.initials: Y
authors.lastname: Qiu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Jianting
authors.initials: J
authors.lastname: Wang
authors.forename: Renmin
authors.initials: R
authors.lastname: Gong
authors.forename: Mingming
authors.initials: M
authors.lastname: Zheng
authors.forename: Fenghong
authors.initials: F
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D048271:Chitosan / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D005632:Fructose / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy; D010840:Phytosterols / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010840:Phytosterols; D005632:Fructose; D004317:Doxorubicin; D048271:Chitosan