title: Obesity-related glomerulopathy and the nephron complement.
abstract: Obesity-related glomerulopathy (ORG) is a secondary form of glomerular disease that can occur in individuals with obesity. However, the absolute risk for an obese individual to develop progressive renal deterioration is low. Therefore, obesity alone appears to be insufficient to develop such severe renal injury, and there are likely other factors that contribute to the development of this entity. The glomerular hyperfiltration found in patients with ORG has been postulated to lead to structural abnormalities in glomeruli, such as glomerulomegaly and focal segmental glomerular sclerosis, in a manner analogous to that described in patients with reduced renal mass. In fact, recent studies suggest that a reduction in nephron mass is implicated in patients with ORG and synergistically contributes to the development of this renal complication together with obesity-induced changes in renal hemodynamics.
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tsuboi
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Utsunomiya
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D000818:Animals; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D009399:Nephrons / Q000473:pathology*; D009765:Obesity / Q000150:complications*
keywords: glomerular density; glomerulomegaly; hyperfiltration; nephron number; obesity