title: Platelets and matrix metalloproteinases.
abstract: Matrix metalloproteinases (MMPs) and their inhibitors essentially contribute to a variety of pathophysiologies by modulating cell migration, tissue degradation and inflammation. Platelet-associated MMP activity appears to play a major role in these processes. First, platelets can concentrate leukocyte-derived MMP activity to sites of vascular injury by leukocyte recruitment. Second, platelets stimulate MMP production in e.g. leukocytes, endothelial cells, or tumour cells by direct receptor interaction or/and by paracrine pathways. Third, platelets synthesise and secrete a variety of MMPs including MMP-1, MMP-2, MMP-3, and MMP-14 (MT1-MMP), and potentially MMP-9 as well as the tissue inhibitors of metalloproteinase (TIMPs). This review focuses on platelet-derived and platelet-induced MMPs and their inhibitors.
authors.affiliation: Peter Seizer, Medizinische Klinik III, Universitätsklinikum Tübingen, Otfried Müller-Str.10, 72076 Tübingen, Germany, Tel.: +49 7071 29 83160; Fax: +49 7071 29 4473, E-mail: peter.seizer@med.uni-tuebingen.de.
authors.forename: P
authors.initials: P
authors.lastname: Seizer
authors.forename: A E
authors.initials: AE
authors.lastname: May
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D007962:Leukocytes / Q000276:immunology*; D061965:Matrix Metalloproteinase Inhibitors / Q000276:immunology; D020782:Matrix Metalloproteinases / Q000276:immunology*; D019899:Paracrine Communication
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases
keywords: EMMPRIN; MMP; Platelets