title: Oxidative cross-coupling/cyclization to build polysubstituted pyrroles from terminal alkynes and β-enamino esters.
abstract: A novel silver-mediated highly selective synthesis of polysubstituted pyrroles by the C-H/C-H oxidative cross-coupling/cyclization of terminal alkynes with β-enamino esters has been developed. This protocol represents a simple, efficient and selective way to construct polysubstituted pyrroles in good yields from basic chemical materials.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, Hubei, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ke
authors.forename: Chuan
authors.initials: C
authors.lastname: He
authors.forename: Huiying
authors.initials: H
authors.lastname: Liu
authors.forename: Mengjun
authors.initials: M
authors.lastname: Li
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004952:Esters / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D012834:Silver / Q000737:chemistry
chemical_list: D000480:Alkynes; D000588:Amines; D004952:Esters; D011758:Pyrroles; D012834:Silver