title: Epidemiology and risk factors for chronic kidney disease in patients with ischaemic stroke.
abstract: BACKGROUND
  There is growing evidence for an association between chronic renal disease (CKD) and adverse cerebrovascular events because of the overlap of several risk factors. The purpose of this study is to examine the epidemiology of CKD and the characteristics of risk factors for CKD in the population with ischaemic stroke.
  
  
  METHODS
  This retrospective study included 571 patients with ischaemic stroke. Estimated glomerular filtration rate (eGFR) was calculated by the Modification of Diet in Renal Disease (MDRD) study equation. Renal function was assessed according to the Kidney Disease Outcomes Quality Initiative (K/DOQI)-CKD classification.
  
  
  RESULTS
  Study demonstrated that the major factors associated with CKD in the ischaemic stroke patients were age, diabetes mellitus, hypertension, systolic blood pressure, LDL cholesterol and serum uric acid. Diabetes mellitus (OR 4·146, 95% CI 1·047-16·418, P = 0·043), hypertension and diabetes mellitus (OR 3·574, 95% CI 1·248-10·234, P = 0·018), serum uric acid (OR 1·010, 95% CI 1·006-1·013, P < 0·001) and LDL cholesterol (OR 1·431, 95% CI 1·063-1·928, P = 0·018) were independent risk factors associated with CKD in the patients with ischaemic stroke.
  
  
  CONCLUSIONS
  The patients with ischaemic stroke may be considered as a high-risk population for CKD and be aggressively managed for CKD prevention. The high prevalence of CKD in population with ischaemic stroke prompts the need for greater public awareness about risks of CKD.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China.
authors.forename: Yu-Shi
authors.initials: YS
authors.lastname: Bao
authors.forename: Li-Ting
authors.initials: LT
authors.lastname: Song
authors.forename: Di
authors.initials: D
authors.lastname: Zhong
authors.forename: A-Xia
authors.initials: AX
authors.lastname: Song
authors.forename: Xi-Bei
authors.initials: XB
authors.lastname: Jia
authors.forename: Rui-Chan
authors.initials: RC
authors.lastname: Liu
authors.forename: Ru-Juan
authors.initials: RJ
authors.lastname: Xie
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Na
mesh_terms: D002681:China / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000150:complications / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000453:epidemiology
keywords: Chronic kidney disease; epidemiology; ischaemic stroke; risk factor