title: Total IgE at 6 months predicts remittance or persistence of atopic dermatitis at 14 months.
abstract: Some patients with infantile atopic dermatitis (AD) achieve remission around 1 year old, but in others it persists. The difference between them is unclear. We performed a birth cohort study to find the markers predicting the outcome of infantile AD. We followed up a cohort (n = 314) from birth to 14 months of age, and cord blood was taken from the participants. Some of them (n = 144) had a physical examination and a blood test at 6 and 14 months of age. The subjects who had AD at 6 months (n = 34) were divided into two groups, named the transient group (those who had no AD at 14 months of age; n = 16) and the persistent group (those who still had AD at 14 months of age; n = 18). Then, laboratory data were compared between these two groups. Percentage of CD8 in cord blood lymphocytes and total IgE at 6 months of age in the persistent group was significantly higher than those of the transient group. The area under the curves of a receiver operating characteristic analysis were 0.792 (p = 0.007) and 0.722 (p = 0.027). In the persistent group, total IgE, percentages of T-helper (Th) 2 and phytohemagglutinin-induced IL-4 production from peripheral blood mononuclear cells at 14 months of age were also significantly higher than those of the transient group. Thus Th2 polarization in the persistent group was confirmed. In clinical use, total IgE at 6 months of age is the most useful predictive marker to know the outcome of infantile AD. The clinical trial registration ID is UMIN000002926.
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Kawamoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fukao
authors.forename: Hideo
authors.initials: H
authors.lastname: Kaneko
authors.forename: Kouichiro
authors.initials: K
authors.lastname: Hirayama
authors.forename: Satomi
authors.initials: S
authors.lastname: Sakurai
authors.forename: Takahiro
authors.initials: T
authors.lastname: Arai
authors.forename: Masashi
authors.initials: M
authors.lastname: Kondo
authors.forename: Minako
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Eiko
authors.initials: E
authors.lastname: Matsui
authors.forename: Kenji
authors.initials: K
authors.lastname: Orii
authors.forename: Kimiko
authors.initials: K
authors.lastname: Kasahara
authors.forename: Masao
authors.initials: M
authors.lastname: Takemura
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Seishima
authors.forename: Makoto
authors.initials: M
authors.lastname: Shiraki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Iwasa
authors.forename: Naomi
authors.initials: N
authors.lastname: Kondo
mesh_terms: D002478:Cells, Cultured; D015331:Cohort Studies; D016207:Cytokines / Q000276:immunology; D003876:Dermatitis, Atopic / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D011237:Predictive Value of Tests; D018418:Th2 Cells / Q000276:immunology; D013997:Time Factors
chemical_list: D016207:Cytokines; D007073:Immunoglobulin E