title: [Functional polymorphism of genes inactivating biogenic amines and cognitive deficits in paranoid schizophrenia].
abstract: OBJECTIVE
  The aim of the work was to assess relationship between gene polymorphism of enzymes influencing dopaminergic-, serotoninergic, and noradrenergic transfer and cognitive functioning of paranoid schizophrenic inpatients (ICD-10).
  
  
  METHODS
  The following methods have been used in the study: The Test of Everyday Attention (TEA) and The Visual Object and Space Perception Battery (VOSP), psychiatric scales (SAPS, SANS, BDI) and techniques of genetic engineering (PCR reaction, RFLP and VNTR techniques). Subject groups included 100 schizophrenic patients (57 male) and 50 healthy controls (20 male).
  
  
  RESULTS
  The results revealed positive correlation between polymorphism of Vall 58MetCOMT and cognitive deficits in schizophrenic patients. No statistically significant relationship was elicited between gene polymorphism of Val158Met COMT and VNTR MAO-A in promoter area and schizophrenia onset. Allelic polymorphism ofVall58Met OMT and VNTR MAO-A in promoter area did not differ between the subject groups. The patients with genotype Val/ Val of polymorphism Val 158MetCOMT showed major cognitive deficits.
authors.affiliation: Katedra i Klinika Psychiatrii Uniwersytetu Medycznego w Lublinie Kierownik.
authors.forename: Aneta
authors.initials: A
authors.lastname: Tylec
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kucharska-Pietura
authors.forename: Witold
authors.initials: W
authors.lastname: Jeleniewicz
authors.forename: Marek
authors.initials: M
authors.lastname: Cybulski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Czernikiewicz
mesh_terms: D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics; D012563:Schizophrenia, Paranoid / Q000235:genetics*; D012565:Schizophrenic Psychology; D012917:Social Adjustment
chemical_list: D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase