title: Novel antimicrobial metabolites produced by Sika deer-associated Actinomyces sp. JN411010.
abstract: Three novel metabolites (1, 5 and 10) were isolated from a 25-L fermentation broth of Actinomyces sp. JN411010 together with 11 related compounds. Their structures were determined on the basis of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data analyses. Compounds 1-2, 5-8 and 10 displayed moderate antimicrobial activities against Gram-positive and Gram-negative bacteria. Biosynthetic pathway of 5 and 10 was proposed to be catalysed by polyketide and non-ribosomal peptide gene clusters, respectively.
authors.affiliation: a China-Korea Joint Institute for Animal Science of Jilin Province , Changchun , 130600 , P.R. China.
authors.forename: Yujiao
authors.initials: Y
authors.lastname: Tang
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Jianchun
authors.initials: J
authors.lastname: Qin
authors.forename: Quankai
authors.initials: Q
authors.lastname: Wang
authors.forename: Lihua
authors.initials: L
authors.lastname: Yang
authors.forename: Lingzhi
authors.initials: L
authors.lastname: Xu
authors.forename: Yuling
authors.initials: Y
authors.lastname: Ding
authors.forename: Yang
authors.initials: Y
authors.lastname: Guo
authors.forename: Hongliang
authors.initials: H
authors.lastname: Li
authors.forename: Jingsi
authors.initials: J
authors.lastname: Li
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Sun
authors.forename: Wenchong
authors.initials: W
authors.lastname: Liu
mesh_terms: D039903:Actinobacteria / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D003670:Deer / Q000382:microbiology*; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D054876:Prenylation; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000900:Anti-Bacterial Agents