title: Single-dose oral lacosamide in refractory simple partial status epilepticus: case report and review.
abstract: OBJECTIVE
  This study aimed to present 2 patients with simple partial refractory status epilepticus (RSE) treated with a single oral lacosamide (LCM) dose and to review the literature on this topic.
  
  
  METHODS
  A retrospective description of 2 patients with simple partial RSE treated with 300 mg of LCM per os (p.o.) and a literature review were done.
  
  
  RESULTS
  Both patients responded to single-dose oral LCM treatment with seizure cessation after 30 minutes.
  
  
  CONCLUSIONS
  This is the first report on successful treatment of simple partial RSE with a single-dose of LCM p.o.. Oral LCM might represent an option for treatment of patients presenting with simple partial RSE.
authors.affiliation: Neurology Department, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina. maxihawkes@icloud.com
authors.forename: Maximiliano A
authors.initials: MA
authors.lastname: Hawkes
authors.forename: Marcos
authors.initials: M
authors.lastname: Fernández Suárez
authors.forename: Gabriela
authors.initials: G
authors.lastname: Ugarnes
authors.forename: Carlos
authors.initials: C
authors.lastname: D'Giano
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D000078334:Lacosamide; D026941:Sodium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D013226:Status Epilepticus / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D026941:Sodium Channel Blockers; D000078334:Lacosamide