title: The effect of vitamin A supplementation on retinoic acid-related orphan receptor γt (RORγt) and interleukin-17 (IL-17) gene expression in Avonex-treated multiple sclerotic patients.
abstract: The aim of this study was to investigate the role of vitamin A on RORγt and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and RORγt gene expression. No changes in gene expression occurred in the placebo group.
authors.affiliation: Cellular and Molecular Nutrition Department, School of Nutritional Sciences and Dietetics, Tehran university of Medical Sciences, Tehran, Iran.
authors.forename: Niyaz
authors.initials: N
authors.lastname: Mohammadzadeh Honarvar
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Harirchian
authors.forename: Fariba
authors.initials: F
authors.lastname: Koohdani
authors.forename: Feridoun
authors.initials: F
authors.lastname: Siassi
authors.forename: Mina
authors.initials: M
authors.lastname: Abdolahi
authors.forename: Sama
authors.initials: S
authors.lastname: Bitarafan
authors.forename: Eisa
authors.initials: E
authors.lastname: Salehi
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sahraian
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Eshraghian
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Saboor-Yarghi
mesh_terms: D000328:Adult; D015536:Down-Regulation; D005260:Female; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000627:therapeutic use; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000378:metabolism*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D020381:Interleukin-17; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539900:RORC protein, human; D014815:Vitamins; D014801:Vitamin A; D016899:Interferon-beta; D000068556:Interferon beta-1a