title: Granulocyte colony-stimulating factor administration for infertile women with thin endometrium in frozen embryo transfer program.
abstract: We aimed to evaluate the effectiveness of granulocyte colony-stimulating factor (G-CSF) administration for infertile women with thin endometrium in frozen embryo transfer program. Among 59 infertile patients with thin endometrium (≤7 mm), 34 patients received uterine infusion of recombinant human G-CSF (100 μg/0.6 mL) on the day of ovulation or administration of progesterone or human chorionic gonadotropin, with 40 cycles defined as G-CSF group and 49 previous cycles as self-controlled group, and 25 patients refused, with 80 cycles defined as the control group. Higher proportion of induced cycles and lower proportion of natural cycles were observed in the G-CSF group, when compared to the self-controlled group or control group (P < .05). The cycle cancellation rate was, in descending order, 69.39% in self-controlled group, 48.75% in control group, and 17.50% in G-CSF group, with significant difference (P < .05). The implantation rate and clinical pregnancy rate per embryo transfer were similar in all the groups (P > .05). Our study fails to demonstrate that G-CSF has the potential to improve embryo implantation and clinical pregnancy rate of the infertile women with thin endometrium.
authors.affiliation: 1Department of Obstetrics and Gynecology, Reproductive Medicine Centre, Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Pan
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D015925:Cryopreservation / Q000379:methods*; D004624:Embryo Transfer / Q000379:methods*; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor
keywords: frozen embryo transfer; granulocyte colony-stimulating factor; implantation; pregnancy rate; thin endometrium