title: [Protein kinases role in adaptive phenomenon of heart ischemic postconditioning development].
abstract: Authors submitted an analysis of papers given up an involvement of protein kinases in heart ischemic postconditioning. This analysis of literature source allowed to authors affirms that signaling system of postconditioning can involve kinases: PKC, PI3K, Akt, MEKl/2, ERK1/2, MTOR, p70s6K, GSK3b, PKG and also eNOS, NO, GC, motoKATP channel, ROS, MPT pore. At the same time it is unclear a real contributions of kinases mTOR, p70s6, AMPK and GSK3b in the mechanism of infarct limiting impact of postconditioning. It is required a further study of the chain of signaling events following JAK2 and p38 kinase activation. The knowledge of Ras and Raf-1 role in postconditioning has hypothetical character. The tyrosine kinase significance in postcondi-tioning is unclear, particular Src kinase, which plays an important role in the regulation of cardiac tolerance to an impact of ischemia and reperfusion.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: A G
authors.initials: AG
authors.lastname: Mrochek
authors.forename: I A
authors.initials: IA
authors.lastname: Shchepetkin
authors.forename: J P
authors.initials: JP
authors.lastname: Headrick
authors.forename: L
authors.initials: L
authors.lastname: Hanus
authors.forename: E I
authors.initials: EI
authors.lastname: Barzakh
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Lishmanov
authors.forename: A S
authors.initials: AS
authors.lastname: Gorbunov
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Tsybul'nikov
authors.forename: A N
authors.initials: AN
authors.lastname: Baĭkov
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D006801:Humans; D057775:Ischemic Postconditioning; D009203:Myocardial Infarction / Q000378:metabolism* / Q000503:physiopathology; D011494:Protein Kinases / Q000737:chemistry / Q000145:classification / Q000378:metabolism* / Q000502:physiology; D015424:Reperfusion; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D011494:Protein Kinases