title: Some new [(thione)2Au(diamine)]Cl3 complexes: synthesis, spectroscopic characterization, computational and in vitro cytotoxic studies.
abstract: Recent advances in oncology are focused on developing new complexes of gold(III) with various ligands that show augmented anti-proliferative potential and reduced toxicity as compared to cis-platin. In this study, new Au(III) complexes of the type [(thione)2Au(diamine)]Cl3 are reported, where thione=1,3-imidazolidine-2-thione (Imt), 1,3-Diazinane-2-thione (Diaz) and diamine=1,2-diaminoethane (en), 1,3-diaminopropane (pn) or 1,4-diaminobutane (bn). The solid state IR as well as (13)C and (15)N NMR data indicate that Au(III) center is bonded via sulfur of thiocarbonyl SC site of the thiones and also chelated by the diamines from the trans side of coordinated thiones. Spectroscopic data are evaluated by comparisons with calculated data from the built and optimized structure by GAUSSIAN 09 at the RB3LYP level with LanL2DZ bases set. These new Au(III) complexes based on mixed thione and diamine ligands are very similar to the square planar structure of tetracoordinate [Au(en)2]Cl3complex. In this study, cytotoxicity data for these gold(III) complexes against C6 glioma cell lines are also reported, and the results indicate some complexes have cytotoxicity comparable to cis-platin.
authors.affiliation: Department of Chemistry, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.
authors.forename: Bassem A
authors.initials: BA
authors.lastname: Al-Maythalony
authors.forename: M
authors.initials: M
authors.lastname: Monim-ul-Mehboob
authors.forename: Muhammad
authors.initials: M
authors.lastname: Altaf
authors.forename: Mohammed I M
authors.initials: MI
authors.lastname: Wazeer
authors.forename: Anvarhusein A
authors.initials: AA
authors.lastname: Isab
authors.forename: Saleh
authors.initials: S
authors.lastname: Altuwaijri
authors.forename: Ayesha
authors.initials: A
authors.lastname: Ahmed
authors.forename: Vikram
authors.initials: V
authors.lastname: Dhuna
authors.forename: Gaurav
authors.initials: G
authors.lastname: Bhatia
authors.forename: Kshitija
authors.initials: K
authors.lastname: Dhuna
authors.forename: Sukhdev Singh
authors.initials: SS
authors.lastname: Kamboj
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D051381:Rats; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D054159:Torsion, Mechanical
chemical_list: D000588:Amines; D008024:Ligands; D012996:Solutions; D013871:Thiones; D006046:Gold
keywords: (13)C and (15)N solid state NMR; Au(III) thione complexes; C6 glioma cell lines