title: Science to practice: will contrast agents for molecular imaging of angiogenesis help overcome the limitations of functional vascular imaging?
abstract: Schmieder and colleagues introduced a new molecular magnetic resonance (MR) probe with a promising lipophilic gadolinium chelate complex that provides high relaxivity. Results of in vivo experiments clearly demonstrate the excellence of the probe for longitudinally monitoring α(v)β(3) integrin expression in tumors. In addition, the authors have developed a robust nonrelaxometric analysis method with which to quantify the spatial distribution of molecular MR probes. In combination with a molecular probe targeting angiogenesis, this approach may be superior to functional vascular assessments. It has the potential to enable better detection of angiogenic regions in heterogeneous tumors and to improve the monitoring and individualization of antiangiogenic treatments.
authors.affiliation: Department of Experimental Molecular Imaging University Clinics RWTH Aachen University Pauwelsstrasse 20 52074 Aachen, Germany. fkiessling@ukaachen.de
authors.forename: Fabian
authors.initials: F
authors.lastname: Kiessling
mesh_terms: D003287:Contrast Media; D018450:Disease Progression; D019786:Gadolinium DTPA; D006571:Heterocyclic Compounds; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D039302:Integrin alphaVbeta3 / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D053758:Nanoparticles; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D009942:Organometallic Compounds
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D039302:Integrin alphaVbeta3; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D019786:Gadolinium DTPA