title: Synthesis and polymerization of bicyclic ketals: a practical route to high-molecular weight polyketals.
abstract: Polyketals are an important class of materials for drug delivery to sensitive tissues as they degrade in vivo to nonacidic species. We report the synthesis of high-molecular weight cyclic polyketals by the cationic ring-opening polymerization of bicyclic ketal monomers, which were prepared by the metal-catalyzed rearrangement of epoxy ketones. Three different cyclic polyketals with high molecular weights were synthesized using this protocol.
authors.affiliation: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA.
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Whiting
authors.forename: Geoffrey W
authors.initials: GW
authors.lastname: Coates
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D008970:Molecular Weight; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D011108:Polymers