title: MicroRNAs in skeletal muscle biology and exercise adaptation.
abstract: MicroRNAs (miRNAs) have emerged as important players in the regulation of gene expression, being involved in most biological processes examined to date. The proposal that miRNAs are primarily involved in the stress response of the cell makes miRNAs ideally suited to mediate the response of skeletal muscle to changes in contractile activity. Although the field is still in its infancy, the studies presented in this review highlight the promise that miRNAs will have an important role in mediating the response and adaptation of skeletal muscle to various modes of exercise. The roles of miRNAs in satellite cell biology, muscle regeneration, and various myopathies are also discussed.
authors.affiliation: Department of Physiology and University of Kentucky, Lexington, KY 40516-0298, USA.
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: Kirby
authors.forename: John J
authors.initials: JJ
authors.lastname: McCarthy
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002454:Cell Differentiation; D005609:Free Radicals / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism*; D009135:Muscular Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D032446:Myoblasts / Q000166:cytology / Q000378:metabolism*; D018384:Oxidative Stress; D010807:Physical Endurance / Q000235:genetics*; D055070:Resistance Training; D015398:Signal Transduction
chemical_list: D005609:Free Radicals; D035683:MicroRNAs
keywords: Exercise; Free radicals; MicroRNA; MyomiR; Skeletal muscle