title: Promiscuous seven transmembrane receptors sensing L-α-amino acids.
abstract: A number of nutrient sensing seven trans-membrane (7TM) receptors have been identified and characterized over the past few years. While the sensing mechanisms to carbohydrates and free fatty acids are well understood, the molecular basis of amino acid sensing has recently come to the limelight. The present review describes the current status of promiscuous L-α-amino acid sensors, the calcium sensing receptor (CaSR), the GPRC6A receptor, the T1R1/T1R3 receptor and also their molecular pharmacology, expression pattern and physiological significance.
authors.forename: Sanela
authors.initials: S
authors.lastname: Smajilovic
authors.forename: Petrine
authors.initials: P
authors.lastname: Wellendorph
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Fruebjergvej 3, 2100 Copenhagen, Denmark. hbo@sund.ku.dk.
authors.forename: Hans
authors.initials: H
authors.lastname: Bräuner-Osborne
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D006801:Humans; D017433:Protein Structure, Secondary; D044169:Receptors, Calcium-Sensing / Q000737:chemistry / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism
chemical_list: D000596:Amino Acids; D044169:Receptors, Calcium-Sensing; D018160:Receptors, Cytoplasmic and Nuclear; D043562:Receptors, G-Protein-Coupled