title: A surview of recent patents on anti-infective therapy for Clostridium difficile.
abstract: Clostridium difficile has become the most common infectious cause of healthcare-associated diarrhea, with serious morbidity, prolonged hospitalization and even death. Treatment of the disease utilizing today's therapies does not guarantee a successful outcome. In the past decade, many new ideas and inventions have surfaced exploring different treatment strategies of Clostridium difficile associated diarrhea (CDAD). These treatments include antitoxins, novel antimicrobials, immunoglobulins and large inert synthetic compounds. In this paper, we survey of a number of representative patents issued from 2000 to the present targeting treatment of this difficult and dreaded disease.
authors.affiliation: St. Mary's Hospital Department of Internal Medicine, 56 Franklin Street, Waterbury, CT 06706, USA. germine.soliman@gmail.com
authors.forename: Germine S
authors.initials: GS
authors.lastname: Soliman
authors.forename: Bechoi
authors.initials: B
authors.lastname: Saleib
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Scholand
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000911:Antibodies, Monoclonal; D000992:Antitoxins; D001428:Bacterial Vaccines / Q000494:pharmacology; D001430:Bacteriocins / Q000737:chemistry / Q000494:pharmacology; D016360:Clostridioides difficile / Q000187:drug effects*; D003967:Diarrhea / Q000188:drug therapy / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy; D005243:Feces / Q000382:microbiology; D006801:Humans; D007028:Hypothalamic Hormones / Q000502:physiology; D007136:Immunoglobulins; D008543:Melanins / Q000502:physiology; D058990:Molecular Targeted Therapy; D010330:Patents as Topic; D010907:Pituitary Hormones / Q000502:physiology; D019936:Probiotics / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000911:Antibodies, Monoclonal; D000992:Antitoxins; D001428:Bacterial Vaccines; D001430:Bacteriocins; D007028:Hypothalamic Hormones; D007136:Immunoglobulins; D008543:Melanins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone