title: Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers.
abstract: The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.
authors.affiliation: Université de Bordeaux, CNRS, UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Fremaux
authors.forename: Christel
authors.initials: C
authors.lastname: Dolain
authors.forename: Brice
authors.initials: B
authors.lastname: Kauffmann
authors.forename: Jonathan
authors.initials: J
authors.lastname: Clayden
authors.forename: Gilles
authors.initials: G
authors.lastname: Guichard
mesh_terms: D000621:Aminoisobutyric Acids / Q000737:chemistry; D003959:Diamines / Q000737:chemistry*; D004980:Ethane / Q000031:analogs & derivatives*; D008745:Methylation; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D014508:Urea / Q000031:analogs & derivatives*
chemical_list: D000621:Aminoisobutyric Acids; D003959:Diamines; C100049:2-aminoisobutyric acid; D014508:Urea; D004980:Ethane