title: Disseminated encephalomyelitis-like central nervous system neoplasm in childhood.
abstract: A malignant neoplasm in the central nervous system with diffuse white matter changes on magnetic resonance imaging (MRI) is rare in children. It could be misdiagnosed as acute disseminated encephalomyelitis. This report presents our experience based on 4 patients (3 male, 1 female; aged 7-13 years) whose MRI showed diffuse lesions in white matter and who were initially diagnosed with acute disseminated encephalomyelitis. All of the patients received corticosteroid therapy. After brain biopsy, the patients were diagnosed with gliomatosis cerebri, primitive neuroectodermal tumor and central nervous system lymphoma. We also provide literature reviews and discuss the differentiation of central nervous system neoplasm from acute disseminated encephalomyelitis.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China Department of Neurological Rehabilitation, Qingdao Children's Hospital, Qingdao, China.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China zwhang@pku.edu.cn.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Bao
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China.
authors.forename: Na
authors.initials: N
authors.lastname: Fu
authors.affiliation: Department of Radiology, Peking University First Hospital, Beijing, China.
authors.forename: Jintang
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department of Pathology, Peking University First Hospital, Beijing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China.
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China.
authors.forename: Xiru
authors.initials: X
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001927:Brain Diseases / Q000503:physiopathology*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000175:diagnosis* / Q000188:drug therapy; D019636:Neurodegenerative Diseases / Q000503:physiopathology*
chemical_list: D000305:Adrenal Cortex Hormones; D018931:Antineoplastic Agents, Hormonal
keywords: acute disseminated encephalomyelitis; central nervous system lymphoma; gliomatosis cerebri; magnetic resonance spectroscopy; primitive neuroectodermal tumor