title: HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01.
abstract: HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that HLA-B*58:01 binds and presents KF11 peptide, but HIV-infected HLA-B*58:01(+) cells fail to process KF11. This unexpected finding demonstrates that immunodominance patterns can be influenced by intracellular events independent of HLA binding motifs.
authors.affiliation: Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
authors.forename: Henrik N
authors.initials: HN
authors.lastname: Kløverpris
authors.forename: Anette
authors.initials: A
authors.lastname: Stryhn
authors.forename: Mikkel
authors.initials: M
authors.lastname: Harndahl
authors.forename: Rebecca
authors.initials: R
authors.lastname: Payne
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Towers
authors.forename: Fabian
authors.initials: F
authors.lastname: Chen
authors.forename: Lynn
authors.initials: L
authors.lastname: Riddell
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Walker
authors.forename: Thumbi
authors.initials: T
authors.lastname: Ndung'u
authors.forename: Alasdair
authors.initials: A
authors.lastname: Leslie
authors.forename: Søren
authors.initials: S
authors.lastname: Buus
authors.forename: Philip
authors.initials: P
authors.lastname: Goulder
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D000939:Epitopes / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism; D019562:Viral Load; D014766:Viremia / Q000276:immunology* / Q000378:metabolism; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000276:immunology / Q000378:metabolism
chemical_list: D000939:Epitopes; D015235:HLA-B Antigens; C500126:HLA-B*58:01 antigen; C103707:HLA-B57 antigen; D010446:Peptide Fragments; D054301:gag Gene Products, Human Immunodeficiency Virus