title: [The assessment of metabolism of bone tissue as changes in concentration of biochemical markers of bone turnover in inpatient alcohol dependent women].
abstract: OBJECTIVE
  The aim of this study was the assessment to of metabolism of bone tissue as changes in concentration of biochemical markers of bone turnover in inpatient alcohol dependent women.
  
  
  METHODS
  The studied group consisted of 50 alcohol dependent female patients who were divided in two groups: one with an activity ofAST or ALT above referential values and level of bilirubin and the second one with the activity oftransaminases and level ofbilirubin within referential values. The level of sex hormones and markers of bone turnover such as osteocalcin and collagen cross laps (ctx) were indicated.
  
  
  RESULTS
  In the group with an AST, ALT or BIL above referential values, the concentration of FSH in the ovulation phase and luteal phase as well as LH in luteal phase was significantly higher, while ctx and osteocalcin was lower compared to the group with AST, ALT or BIL within referential values. The mean concentrations ofFSH in follicular phase and luteal phase as well as LH in the luteal phase and progesterone in the follicular phase were increased in the group of patients with AST, ALT or BIL above referential values. The positive correlation between levels ofctx and osteocalcin was found which suggests a balance between processes. of bone formation and bone resorption in the whole group while a lack of such correlation was observed in patients with AST, ALT or BIL above referential values.
  
  
  CONCLUSIONS
  The results obtained indicate the multidirectional and mutual relations between the alcohol abuse, liver function, bone turnover and activity of endocrine system.
authors.affiliation: Katedra Psychiatrii CM UMK Kierownik.
authors.forename: Beata
authors.initials: B
authors.lastname: Augustyńska
authors.forename: Aleksander
authors.initials: A
authors.lastname: Araszkiewicz
authors.forename: Alina
authors.initials: A
authors.lastname: Wozniak
authors.forename: Grazyna
authors.initials: G
authors.lastname: Odrowaz-Sypniewska
authors.forename: Marzena
authors.initials: M
authors.lastname: Gruszka
authors.forename: Sławomir
authors.initials: S
authors.lastname: Manysiak
authors.forename: Monika
authors.initials: M
authors.lastname: Wiłkość
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kosmowski
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism* / Q000628:therapy; D000469:Alkaline Phosphatase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D016723:Bone Remodeling / Q000187:drug effects*; D005260:Female; D006304:Health Status; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008875:Middle Aged; D016387:Women's Health
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin