title: Is thyroid cancer recurrence risk increased after transplantation?
abstract: BACKGROUND
  An increased cancer mortality is reported in transplanted patients.
  
  
  OBJECTIVE
  This multicentric study aimed to investigate the rate of thyroid cancer recurrence after transplantation.
  
  
  RESULTS
  Sixty-eight patients (35 male/33 female) with a history of both thyroid cancer and organ transplantation were recruited via two nationwide French networks. Histological analysis identified 58 papillary (88%), 5 follicular (7.5%), and 3 poorly differentiated cancer cases (4.5 %). Thirty-one patients (52%) presented high recurrence risk tumors. In the 36 patients with thyroid cancer diagnosed after transplantation, the 5-year disease-free survival (DFS) was 74.7% (SE: 7.3%). One patient died after progression of a poorly differentiated cancer. Persistent disease was observed in six high-risk patients. One of them underwent a second transplantation and disease remained stable after 5 years of follow-up. Thyroid cancer had been diagnosed before transplantation in 32 patients. One patient with cystic fibrosis and thyroid lung metastases at the time of lung transplantation underwent a 4-year remission. For the 31 patients in remission at the time of transplantation, the 5-year DFS was 93.1% (SE: 4.8%). Two patients with local recurrence presented subsequent remission. For the entire study population, the 5-year and 9-year DFS were 81.9% (SE: 5.5%) and 75.6% (SE: 7.9%), respectively. Recurrence or persistent disease occurred in patients with high-risk tumors.
  
  
  CONCLUSIONS
  The prognosis of thyroid cancer does not seem to be altered by transplantation. This suggests that a history of thyroid cancer should not be considered a contraindication.
authors.affiliation: Fédération d'Endocrinologie, Groupement Hospitalier Est, 59 Boulevard Pinel, 69677 Bron Cedex, France. francoise.borson-chazot@chu-lyon.fr.
authors.forename: Hélène
authors.initials: H
authors.lastname: Tisset
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.forename: Isabelle
authors.initials: I
authors.lastname: Faugeron
authors.forename: Pascal
authors.initials: P
authors.lastname: Roy
authors.forename: Claire
authors.initials: C
authors.lastname: Pouteil-Noble
authors.forename: Marc
authors.initials: M
authors.lastname: Klein
authors.forename: Georges
authors.initials: G
authors.lastname: Mourad
authors.forename: Delphine
authors.initials: D
authors.lastname: Drui
authors.forename: Christine
authors.initials: C
authors.lastname: Do Cao
authors.forename: Laurence
authors.initials: L
authors.lastname: Leenhardt
authors.forename: Ingrid
authors.initials: I
authors.lastname: Allix
authors.forename: Françoise
authors.initials: F
authors.lastname: Bonichon
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Morelon
authors.forename: Sophie
authors.initials: S
authors.lastname: Leboulleux
authors.forename: Antony
authors.initials: A
authors.lastname: Kelly
authors.forename: Patricia
authors.initials: P
authors.lastname: Niccoli
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Toubert
authors.forename: Luc
authors.initials: L
authors.lastname: Frimat
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Vantyghem
authors.forename: Claire
authors.initials: C
authors.lastname: Bournaud
authors.forename: Martin
authors.initials: M
authors.lastname: Schlumberger
authors.forename: Françoise
authors.initials: F
authors.lastname: Borson-Chazot
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D016377:Organ Transplantation / Q000009:adverse effects*; D012306:Risk; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome