title: [Meta-analysis of association between E-cadherin promoter methylation and lung cancer risk].
abstract: OBJECTIVE
  As a member of the cadherin superfamily, E-cadherin plays a critical role in the maintenance of cell polarity and integrity. And E-cadherin was reported to be down-regulated and closely related to tumor initiation, invasion and metastasis. There have been a number of studies investigating the methylation of E-cadherin promoter in relation to various cancers. However, the association between E-cadherin promoter methylation and lung cancer risk is controversial. The aim of the present study is to evaluate the association of E-cadherin promoter methylation with risk of lung cancer by conducting a systematic meta-analysis.
  
  
  METHODS
  Relevant studies were identified by searches of PubMed/MedLine and EMBASE databases before March 2013. Combined odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association between E-cadherin promoter methylation and lung cancer risk.
  
  
  RESULTS
  A total of 1,288 samples from 13 independent studies were included in the meta-analysis. Overall, a significant association was observed between E-cadherin promoter methylation and lung cancer risk (OR=4.04, 95%CI: 2.00-8.13, P<0.001). Subgroup analyses by ethnic revealed that lung cancer risk was increased for individuals carrying the methylated E-cadherin in Asian and Caucasian populations (OR=3.28, 95%CI: 1.20-8.92; OR=5.72, 95%CI: 2.40-13.62).
  
  
  CONCLUSIONS
  The present meta-analysis indicates that the methylation of E-cadherin promoter is associated with risk of lung cancer.
authors.affiliation: Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou Key Laboratory  for Molecular Cancer Genetic, Suzhou 215123, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zeng
authors.forename: Rengyun
authors.initials: R
authors.lastname: Liu
authors.forename: Hongtao
authors.initials: H
authors.lastname: Zhang
mesh_terms: D015820:Cadherins / Q000235:genetics*; D019175:DNA Methylation; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: D015820:Cadherins