title: An evaluation of circulating bovine viral diarrhea virus type 2 maternal antibody level and response to vaccination in Angus calves.
abstract: Vaccination against viruses has been shown to help prevent bovine respiratory disease in cattle. However, both passively acquired maternal antibody concentration and calf age have been shown to impact the ability of the immune system of a calf to respond to vaccination. The objectives of this study were to identify and evaluate environmental and management factors that affect 1) passively acquired bovine viral diarrhea virus (BVDV) type 2 antibody level, 2) decay rate of passively acquired BVDV type 2 antibody level, and 3) responses to BVDV type 2 vaccinations. A 2-shot modified live vaccine was administered to 1,004 Angus calves that were weaned at either the initial vaccination (n = 508) or the booster vaccination (n = 496). Calves weaned at the initial vaccination averaged 139 d whereas calves weaned at booster vaccination averaged 128 d of age. Bovine viral diarrhea virus type 2 antibodies were measured in 3 approximately 21-d intervals, serially collected serum samples to quantify antibody levels at initiation and end of vaccination protocol in addition to responses to initial, booster, and overall vaccination protocol. Amount of passively transferred antibody in the calf increased as dam age increased from 2 to 6 yr (P < 0.05) with no differences after dams reached 6 yr (P > 0.05). Calf age nested within birth year-season and dam age affected both initial and final antibody level, initial response, booster response, and overall antibody response to vaccination. The level of circulating, passively acquired maternal antibodies present at the time of vaccination had a significant (P < 0.05) negative effect on antibody responses to vaccination (initial response, booster response, and overall response). Calves that were weaned at the time of initial vaccination had significantly (P < 0.05) greater final antibody level, initial response, and overall response to vaccination than animals weaned at booster vaccination. In order for a calf to mount an overall antibody response to vaccination, maternal antibodies in circulation need to be less than 3.12 titers. However, the age at which a calf reached this antibody threshold was dependent on dam age. This information will help cattle managers and consultants design vaccination protocols to successfully mount an antibody response to vaccination.
authors.affiliation: Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: E D
authors.initials: ED
authors.lastname: Downey
authors.forename: R G
authors.initials: RG
authors.lastname: Tait
authors.forename: M S
authors.initials: MS
authors.lastname: Mayes
authors.forename: C A
authors.initials: CA
authors.lastname: Park
authors.forename: J F
authors.initials: JF
authors.lastname: Ridpath
authors.forename: D J
authors.initials: DJ
authors.lastname: Garrick
authors.forename: J M
authors.initials: JM
authors.lastname: Reecy
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002417:Cattle / Q000254:growth & development; D030242:Diarrhea Virus 2, Bovine Viral / Q000276:immunology*; D005260:Female; D030243:Hemorrhagic Syndrome, Bovine / Q000097:blood / Q000517:prevention & control* / Q000821:virology; D007112:Immunity, Maternally-Acquired; D008297:Male; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines