title: Nano-transfersomes as a novel carrier for transdermal delivery.
abstract: The aim of this study was to design and optimize a nano-transfersomes of Diclofenac diethylamine (DDEA) and Curcumin (CRM). A 3(3) factorial design (Box-Behnken) was used to derive a polynomial equation (second order) to construct 2-D (contour) and 3-D (Response Surface) plots for prediction of responses. The ratio of lipid to surfactant (X1), weight of lipid to surfactant (X2) and sonication time (X3) (independent variables) and dependent variables [entrapment efficiency of DDEA (Y1), entrapment efficiency of CRM (Y2), effect on particle size (Y3), flux of DDEA (Y4), and flux of CRM (Y5)] were studied. The 2-D and 3-D plots were drawn and a statistical validity of the polynomials was established to find the compositions of optimized formulation. The design established the role of the derived polynomial equation, 2-D and 3-D plots in predicting the values of dependent variables for the preparation and optimization of nano-transfersomes for transdermal drug release.
authors.affiliation: PDM College of Pharmacy, Bahadurgrah, India. hema.manan@gmail.com
authors.forename: Hema
authors.initials: H
authors.lastname: Chaudhary
authors.forename: Kanchan
authors.initials: K
authors.lastname: Kohli
authors.forename: Vikash
authors.initials: V
authors.lastname: Kumar
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*; D008297:Male; D015233:Models, Statistical; D053758:Nanoparticles; D036103:Nanotechnology; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D012995:Solubility; D013010:Sonication; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D004337:Drug Carriers; D008055:Lipids; D013501:Surface-Active Agents; D004008:Diclofenac; D003474:Curcumin
keywords: Drug design; Drug transport; Factorial design; Formulation; Nano-transfersomes; Transdermal delivery