title: Vaccines against Coccidioides.
abstract: Vaccines against fungal diseases are gaining attention because of their growing impact on modern medicine. Development of these vaccines should incorporate immunological tools that integrate with or replace chemotherapy to minimize antibiotic use and consequent resistance. In this review, we evaluate the current developmental status of fungal vaccines against coccidioidomycosis. There is a need for a vaccine that sufficiently prevents disease, without eradicating the fungus, by neutralizing adhesions and enzymes or other low penetrance virulence traits.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Eulji University Hospital, Daejeon, Korea. yhj822@medimail.co.kr
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Karl V
authors.initials: KV
authors.lastname: Clemons
mesh_terms: D000818:Animals; D003045:Coccidioides / Q000276:immunology* / Q000472:pathogenicity; D003047:Coccidioidomycosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D005657:Fungal Vaccines / Q000627:therapeutic use*; D006801:Humans; D014774:Virulence
chemical_list: D005657:Fungal Vaccines
keywords: Coccidioidomycosis; Fungal vaccines