title: Copper-catalyzed P-arylation via direct coupling of diaryliodonium salts with phosphorus nucleophiles at room temperature.
abstract: A new method for copper-catalyzed P-C bond formation through reaction of phosphorus nucleophiles with diaryliodonium salts at room temperature is described. Most target products are obtained with this method in high yields within a short reaction time of 10 min. It can be easily adapted to large-scale preparations. When unsymmetrical iodonium salts are employed, nucleophilic substitution occurs preferentially on the sterically hindered aromatic ring or the more electron-deficient ring.
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Pengbo
authors.initials: P
authors.lastname: Zhang
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Gao
authors.forename: Yiyin
authors.initials: Y
authors.lastname: Chen
authors.forename: Guo
authors.initials: G
authors.lastname: Tang
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010758:Phosphorus / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D013696:Temperature
chemical_list: D006847:Hydrocarbons, Iodinated; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D012492:Salts; D010758:Phosphorus; D003300:Copper