title: [Outcomes of advanced gastric cancer patients treated with chemoradiation therapy].
abstract: We retrospectively analyzed 20 patients with advanced gastric cancer treated with chemoradiation(CRT). The patients consisted of 16 males and 4 females, 17(85%)of whom received intensive chemotherapy prior to CRT. Radiation was administered concurrently at 40 to 55 Gy according to the purpose of treatment. Sixteen patients received low dose CDDP and S-1. Of 8 patients who had measurable disease, one obtained CR and 3 obtained PR by the CRT. Fifteen percent of the distinct adverse effects of CRT were grade 3 leucopenia and 30% of them were grade 3 nausea. The 2-year-survival of patients who received CRT with curative intent was 91%, significantly higher than the percentage of those with palliative intent. Four patients who received R0 surgery following CRT are postoperatively healthy without symptoms of relapse. In conclusion, even though, 75% of the patients were already given chemotherapy prior to CRT, good outcomes were achieved unexpectedly. The combination of CRT and surgery may be a useful tool for chemo-resistant, locally advanced gastric cancer.
authors.affiliation: Dept. of Digestive Surgery, Breast and Thyroid, Kagoshima University School of Medicine, Japan.
authors.forename: Sumiya
authors.initials: S
authors.lastname: Ishigami
authors.forename: Takaaki
authors.initials: T
authors.lastname: Arigami
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Uenosono
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okumura
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Uchikado
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Owaki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kijima
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nakajo
authors.forename: Kousei
authors.initials: K
authors.lastname: Maemura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ueno
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hokita
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hiraki
authors.forename: Masataka
authors.initials: M
authors.lastname: Nakajo
authors.forename: Shoji
authors.initials: S
authors.lastname: Natsugoe
mesh_terms: D000328:Adult; D000368:Aged; D059248:Chemoradiotherapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult