title: Zopolrestat as a human glyoxalase I inhibitor and its structural basis.
authors.affiliation: Centre for Cellular & Structural Biology, School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle, University City, Guangzhou 510006, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhai
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Ligping
authors.initials: L
authors.lastname: Zhang
authors.forename: Yining
authors.initials: Y
authors.lastname: Zhao
authors.forename: Sangke
authors.initials: S
authors.lastname: Chen
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Chen
authors.forename: Xinyu
authors.initials: X
authors.lastname: Peng
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Minggui
authors.initials: M
authors.lastname: Yuan
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Hu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000378:metabolism; D052160:Benzothiazoles / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000737:chemistry / Q000378:metabolism; D007791:Lactoylglutathione Lyase / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D010793:Phthalazines / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052160:Benzothiazoles; D004791:Enzyme Inhibitors; D010793:Phthalazines; C067172:zopolrestat; D007791:Lactoylglutathione Lyase; D007213:Indomethacin
keywords: crystal structures; glyoxalase I; indomethacin; inhibitors; zinc metalloenzymes; zopolrestat