title: Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants.
abstract: Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL). We investigated whether FLG mutation inheritance, skin barrier impairment, and AD also predispose to allergic sensitization to foods. Six hundred and nineteen exclusively breastfed infants were recruited at 3 months of age and examined for AD and disease severity (SCORing Atopic Dermatitis (SCORAD)), and screened for the common FLG mutations. TEWL was measured on unaffected forearm skin. In addition, skin prick testing was performed to six study foods (cow's milk, egg, cod, wheat, sesame, and peanut). Children with AD were significantly more likely to be sensitized (adjusted odds ratio (OR)=6.18, 95% confidence interval (CI): 2.94-12.98, P<0.001), but this effect was independent of FLG mutation carriage, TEWL, and AD phenotype (flexural vs. non-flexural). There was also a strong association between food sensitization and AD severity (adjusted ORSCORAD<20=3.91, 95% CI: 1.70-9.00, P=0.001 vs. adjusted ORSCORAD20=25.60, 95% CI: 9.03-72.57, P<0.001). Equally, there was a positive association between AD and sensitization with individual foods (adjusted ORegg=9.48, 95% CI: 3.77-23.83, P<0.001; adjusted ORcow's milk=9.11, 95% CI: 2.27-36.59, P=0.002; adjusted ORpeanut=4.09, 95% CI: 1.00-16.76, P=0.05). AD is the main skin-related risk factor for food sensitization in young infants. In exclusively breastfed children, this suggests that allergic sensitization to foods can be mediated by cutaneous antigen-presenting cells.
authors.affiliation: St John's Institute of Dermatology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.|Children's Allergies Department, Division of Asthma, Allergy and Lung Biology, King's College London.
authors.forename: Carsten
authors.initials: C
authors.lastname: Flohr
authors.affiliation: Children's Allergies Department, Division of Asthma, Allergy and Lung Biology, King's College London.
authors.forename: Michael
authors.initials: M
authors.lastname: Perkin
authors.affiliation: Children's Allergies Department, Division of Asthma, Allergy and Lung Biology, King's College London.
authors.forename: Kirsty
authors.initials: K
authors.lastname: Logan
authors.affiliation: Children's Allergies Department, Division of Asthma, Allergy and Lung Biology, King's College London.
authors.forename: Tom
authors.initials: T
authors.lastname: Marrs
authors.affiliation: Children's Allergies Department, Division of Asthma, Allergy and Lung Biology, King's College London.
authors.forename: Suzana
authors.initials: S
authors.lastname: Radulovic
authors.affiliation: Centre for Dermatology and Genetic Medicine, Division of Molecular Medicine, University of Dundee, Dundee, UK.
authors.forename: Linda E
authors.initials: LE
authors.lastname: Campbell
authors.affiliation: Centre for Dermatology and Genetic Medicine, Division of Molecular Medicine, University of Dundee, Dundee, UK.
authors.forename: Stephanie F
authors.initials: SF
authors.lastname: MacCallum
authors.affiliation: Centre for Dermatology and Genetic Medicine, Division of Molecular Medicine, University of Dundee, Dundee, UK.
authors.forename: W H Irwin
authors.initials: WHI
authors.lastname: McLean
authors.affiliation: Children's Allergies Department, Division of Asthma, Allergy and Lung Biology, King's College London.
authors.forename: Gideon
authors.initials: G
authors.lastname: Lack
mesh_terms: D000818:Animals; D010367:Arachis; D001942:Breast Feeding / Q000706:statistics & numerical data*; D002417:Cattle; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D004531:Eggs; D005260:Female; D000091344:Filaggrin Proteins; D005399:Fishes; D005512:Food Hypersensitivity / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D006801:Humans; D007223:Infant; D007381:Intermediate Filament Proteins / Q000235:genetics*; D008297:Male; D008892:Milk; D009154:Mutation; D012307:Risk Factors; D031685:Sesamum; D012720:Severity of Illness Index; D012882:Skin Tests; D014908:Triticum
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins