title: The epidemiology of human T-cell lymphotropic virus types I and II in Canadian blood donors.
abstract: OBJECTIVE
  Blood donors in Canada have been tested for Human T-Cell Lymphotropic Virus (HTLV) since 1990. We report the epidemiology, risk factors and lookback/traceback of HTLV-positive donors/recipients.
  
  
  METHODS
  The annual HTLV rate was calculated from 1990 to 2010. Residual risk was estimated as the product of incidence and window period. Twenty-nine HTLV-positive donors and 116 matched controls (ratio 1 : 4) were interviewed about risk factors. For HTLV-positive donations, lookback investigations involved identification of all previous donations, and attempting to locate and test recipients. Traceback was initiated when transfusion transmission was queried for HTLV-positive blood recipients. All donors of products that the recipient received were identified, with an attempt to locate and test them.
  
  
  RESULTS
  The HTLV rate decreased from 9.35 per 100,000 donations in 1990 to 1.11 in 2010. The residual risk of infection was 1 in 7.6 million donations. In logistic regression birth overseas (OR 18.7), history of sexually transmitted diseases (OR 32.9), sex with unknown background (OR 5.4) and blood transfusion (OR 8.9) were significant predictors. In the lookback study, of 109 HTLV-positive donors, 508 components were transfused, of whom 147 recipients were tested and 18 (12%) were positive. All were transfused prior to the implementation of donor testing. Twenty-three traceback investigations were requested involving 324 transfused untested products,of whom 219 (67.6%) of donors were tested and 13 (6%) were positive for HTLV.
  
  
  CONCLUSIONS
  With testing of the blood supply, the risk from HTLV is very low and while most HTLV-positive donors have risk factors, deferrable risk is rare.
authors.affiliation: Canadian Blood Services, Ottawa, ON, Canada; Department of Epidemiology & Community Medicine.
authors.forename: S F
authors.initials: SF
authors.lastname: O'Brien
authors.forename: M
authors.initials: M
authors.lastname: Goldman
authors.forename: V
authors.initials: V
authors.lastname: Scalia
authors.forename: Q-L
authors.initials: QL
authors.lastname: Yi
authors.forename: W
authors.initials: W
authors.lastname: Fan
authors.forename: G
authors.initials: G
authors.lastname: Xi
authors.forename: I R
authors.initials: IR
authors.lastname: Dines
authors.forename: M A
authors.initials: MA
authors.lastname: Fearon
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D001803:Blood Transfusion; D002170:Canada / Q000453:epidemiology; D046148:Donor Selection; D005260:Female; D015490:HTLV-I Infections / Q000453:epidemiology*; D015491:HTLV-II Infections / Q000453:epidemiology*; D015368:Human T-lymphotropic virus 1; D015367:Human T-lymphotropic virus 2; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
keywords: HTLV; epidemiology; risk factors