title: Anti-ganglioside antibodies in patients with Guillain Barré syndrome and other neurological disorders.
abstract: A study was performed on 59 Guillain-Barré syndrome (GBS) cases, 58 neurological controls (NC) and 60 non-neurological controls (NNC) to investigate the association of anti-ganglioside antibodies in GBS and other neurological disorders. Campylobacter jejuni was isolated from 5.7% of GBS patients. Anti-ganglioside immunoglobulin G was present in 82% and immunoglobulin M in 46% in acute inflammatory demyelinating polyneuropathy patients, 70% and 44% respectively in acute motor axonal neuropathy subgroup and 38% each in acute motor sensory axonal neuropathy subgroup. Though high intensity of anti-gangliosides was present in the GBS patients, the NC patients also had adequate anti-gangliosides compared with the NNC group.
authors.affiliation: Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: C
authors.initials: C
authors.lastname: Vaishnavi
authors.forename: C
authors.initials: C
authors.lastname: Behura
authors.forename: S
authors.initials: S
authors.lastname: Prabhakar
authors.forename: A
authors.initials: A
authors.lastname: Sharma
authors.forename: P
authors.initials: P
authors.lastname: Kharbanda
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D016123:Campylobacter jejuni / Q000302:isolation & purification; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D009422:Nervous System Diseases / Q000276:immunology* / Q000473:pathology
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; D007075:Immunoglobulin M