title: Video-EEG recordings in full-term neonates of diabetic mothers: observational study.
abstract: OBJECTIVE
  To determine whether full-term newborn infants of diabetic mothers (IDM) present immature/disorganised EEG patterns in the immediate neonatal period, and whether there was any relationship with maternal glycaemic control.
  
  
  METHODS
  Cohort study with an incidental sample performed in a tertiary hospital neonatal unit.
  
  
  METHODS
  23 IDM and 22 healthy newborns born between 2010 and 2013.
  
  
  METHODS
  All underwent video-EEG recording lasting >90 min at 48-72 h of life.
  
  
  METHODS
  We analysed the percentage of indeterminate sleep, transient sharp waves per hour and mature-for-gestational age EEG patterns (discontinuity, maximum duration of interburst interval (IBI), asynchrony, asymmetry, δ brushes, encoches frontales and α/θ rolandic activity). The group of IDM was divided into two subgroups according to maternal HbA1c: (1) HbA1c≥6% and (2) HbA1c<6%.
  
  
  RESULTS
  Compared with healthy newborns, IDM presented significantly higher percentage of indeterminate sleep (57% vs 25%; p<0.001), discontinuity (2.5% vs 0%; p=0.044) and δ brushes in the bursts (6% vs 3%; p=0.024); higher duration of IBI (0.3 s vs 0 s; p=0.017); fewer encoches frontales (7/h vs 35/h; p<0.001), reduced θ/α rolandic activity (3/h vs 9/h; p<0.001); and more transient sharp waves (25/h vs 5/h; p<0.001). IDM with maternal HbA1c≥6% showed greater percentage of δ brushes in the burst (14% vs 4%; p=0.007).
  
  
  CONCLUSIONS
  Full-term IDM newborns showed video-EEG features of abnormal development of brain function. Maternal HbA1c levels<6% during pregnancy could minimise the risk of cerebral dysmaturity.
authors.affiliation: Department of Neonatology, Hospital Universitario de Canarias, , La Laguna, Spain.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Castro Conde
authors.forename: Nieves Luisa
authors.initials: NL
authors.lastname: González González
authors.forename: Desiré
authors.initials: D
authors.lastname: González Barrios
authors.forename: Candelaria
authors.initials: C
authors.lastname: González Campo
authors.forename: Yaiza
authors.initials: Y
authors.lastname: Suárez Hernández
authors.forename: Elena
authors.initials: E
authors.lastname: Sosa Comino
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000503:physiopathology; D001927:Brain Diseases / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D002657:Child Development; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis*; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D005865:Gestational Age; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D009035:Mothers; D011247:Pregnancy; D013223:Statistics as Topic; D047929:Term Birth; D014741:Video Recording / Q000706:statistics & numerical data
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Clin Neurophysiology; Diabetes; Fetal Medicine; Neonatology; Neurodevelopment