title: Genetic associations with hypertension: meta-analyses of six candidate genetic variants.
abstract: OBJECTIVE
  The aim of this study was to perform combined analyses of six genetic variants for the risk of hypertension.
  
  
  METHODS
  After a comprehensive literature search for genetic variants involved with the association study of hypertension, we harvested a total of five genes (six variants) for the current meta-analyses. These genes consisted of CYP4A11 (T8590C), RGS2 (1891-1892del TC and G638A), HTR2A (T102C), GNAS (T393C), and HSD3B1 (T→C Leu338).
  
  
  RESULTS
  A total of 20 studies among 13,816 cases and 19,248 controls were retrieved for the meta-analyses of six genetic variants. It was shown that the RGS2 1891-1892del TC (OR=1.10, 95% CI=1.02-1.19, p=0.02) polymorphism and the CYP4A11 T8590C (OR=1.19, 95% CI=1.00-1.41, p=0.05) polymorphism were significantly associated with increased risk of hypertension. No association was found between the other four variants and the risk of hypertension.
  
  
  CONCLUSIONS
  This meta-analysis revealed that the RGS2 1891-1892del TC polymorphism and CYP4A11 T8590C polymorphism were associated with hypertension risk. However, HSD3B1 T→C Leu338, HTR2A T102C, GNAS T393C, and RGS2 G638A polymorphisms were not associated with hypertension risk.
authors.affiliation: 1 Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University , Ningbo, Zhejiang, China .
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Lingyan
authors.initials: L
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Liao
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
authors.forename: Leiting
authors.initials: L
authors.lastname: Xu
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Huadan
authors.initials: H
authors.lastname: Ye
authors.forename: Xuting
authors.initials: X
authors.lastname: Xu
authors.forename: Meng
authors.initials: M
authors.lastname: Ye
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
mesh_terms: D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors