title: Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: a randomized double-blind placebo-controlled study.
abstract: The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery. The study design was randomized, double-blind, placebo-controlled, parallel trial. Totally 136 shift workers with a depression score ≥10 in 21-item Beck Depression Rating Scale were randomly assigned to receive omega-3 (180 mg eicosapentaenoate acid and 120 mg docosahexaenoic acid) or/and vitamin C 250 mg or placebo twice daily (with the same taste and shape as omega-3 and vitamin C) for 60 days in four groups. Depression score, interleukin-6 and high sensitivity C-reactive protein were measured at baseline and after 60 days. This study showed that supplementation of omega-3 plus vitamin C is associated with a decrease in depression score (p<0.05). Supplementation of omega-3 without vitamin C, is associated with a reduction in depression score (p<0.0001) and high sensitivity C-reactive protein concentration (p<0.01). Therefore omega-3 supplementation showed a better effect on reducing depression score and high sensitivity C-reactive protein, but supplementation of vitamin C along with omega-3 did not have significant effect on change in C-reactive protein level compared to omega-3 alone. (
  
  
  BACKGROUND
  IRCT201202189056N1).
authors.affiliation: Department of Occupational & Environmental Health, Faculty of Medical Sciences, Tarbiat Modares University, POB 14115-111, Tehran, Iran.
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Khajehnasiri
authors.forename: Seyed Bagher
authors.initials: SB
authors.lastname: Mortazavi
authors.forename: Abdolamir
authors.initials: A
authors.lastname: Allameh
authors.forename: Shahin
authors.initials: S
authors.lastname: Akhondzadeh
keywords: depression; high sensitivity C-reactive protein (hs-CRP); interleukin-6 (IL-6); omega-3 fatty acids; vitamin C