title: Synthesis of telmisartan impurity B.
abstract: Telmisartan is an antihypertensive drug and is a specific angiotensin II receptor (AT1) antagonist. According to European Pharmacopoeia 7 Edition 2008 telmisartan quality standard, there are seven impurities in telmisartan. Impurity B which is not available commercially and no synthetic method is published so far. We report herein the first synthesis of impurity B. The structure of impurity B was confirmed by 1H NMR, 13C NMR and MS data. These findings should be important for quality control purposes in the manufacture and quality control of telmisartan.
authors.affiliation: College of Chemistry, Jilin University, Changchun, PR China.
authors.forename: Lun
authors.initials: L
authors.lastname: Zhao
authors.forename: Haijian
authors.initials: H
authors.lastname: Xia
authors.forename: Zi-Chen
authors.initials: ZC
authors.lastname: Wang
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis*; D001565:Benzoates / Q000138:chemical synthesis*; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D004340:Drug Contamination; D007202:Indicators and Reagents; D011786:Quality Control; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization; D000077333:Telmisartan
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D007202:Indicators and Reagents; D012997:Solvents; D000077333:Telmisartan