title: Apolipoprotein E genotypes associated with Alzheimer disease and concomitant stroke.
abstract: BACKGROUND
  The ɛ4 allele of the apolipoprotein E (APOE) gene is a well-characterized genetic risk factor for Alzheimer disease (AD). The association between stroke and a higher risk for AD has also been reported. Our study sought to determine the relationship between the APOE gene and AD and the comorbid risk of stroke.
  
  
  METHODS
  The subjects of this study consisted of 48 patients with AD and 48 members of a control group. All subjects were genotyped for APOE.
  
  
  RESULTS
  The results clearly show a significant increased risk of AD in carriers of the APOE ε3/ε4 genotype (P = .003, odds ratio [OR] = 4.1) or ε4 allele (P = .001, OR = 4.2). The risk for stroke in AD patients was also increased for carriers of the APOE ε3/ε4 genotype (P = .02, OR = 9.0) and for carriers of the APOE ε4 allele (P = .004, OR = 5.5).
  
  
  CONCLUSIONS
  The present study is the first to establish a relationship between APOE ε4 and concomitant AD and stroke in the Tunisian population.
authors.affiliation: Laboratoire de Biologie Moléculaire, Service d'Hématologie, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis, Tunisie; Académie Militaire Fondouk Jédid, Nabeul, Tunisie. Electronic address: fnajiba@yahoo.fr.
authors.forename: Najiba
authors.initials: N
authors.lastname: Fekih-Mrissa
authors.affiliation: Laboratoire de Biologie Moléculaire, Service d'Hématologie, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis, Tunisie; Faculté des Sciences de Tunis, Université de Tunis El Manar, El Manar, Tunisie.
authors.forename: Sarra
authors.initials: S
authors.lastname: Klai
authors.affiliation: Laboratoire de Biologie Moléculaire, Service d'Hématologie, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis, Tunisie; Faculté des Sciences de Tunis, Université de Tunis El Manar, El Manar, Tunisie.
authors.forename: Meriem
authors.initials: M
authors.lastname: Mrad
authors.affiliation: Service de Neurologie, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis, Tunisie; Faculté de Médecine de Tunis, Université de Tunis El Manar, Tunis, Tunisie.
authors.forename: Malek
authors.initials: M
authors.lastname: Mansour
authors.affiliation: Service de Neurologie, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis, Tunisie; Faculté de Médecine de Tunis, Université de Tunis El Manar, Tunis, Tunisie.
authors.forename: Jamel
authors.initials: J
authors.lastname: Zaouali
authors.affiliation: Laboratoire de Biologie Moléculaire, Service d'Hématologie, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis, Tunisie; Faculté de Pharmacie, Université de Monastir, Monastir, Tunisie.
authors.forename: Nasreddine
authors.initials: N
authors.lastname: Gritli
authors.affiliation: Service de Neurologie, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis, Tunisie; Faculté de Médecine de Tunis, Université de Tunis El Manar, Tunis, Tunisie.
authors.forename: Ridha
authors.initials: R
authors.lastname: Mrissa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000150:complications* / Q000453:epidemiology / Q000235:genetics*; D053318:Apolipoprotein E3 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000453:epidemiology / Q000235:genetics*; D014416:Tunisia / Q000453:epidemiology
chemical_list: D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D004247:DNA
keywords: Alzheimer disease; Apolipoprotein E; genotyping; risk factor; stroke