title: [In vitro evaluation of antibacterial activity and cytocompatibility of antibacterial stainless steel containing copper].
abstract: To study the in vitro antibacterial activity and biocompatibility of 317L stainless steel containing 4.5% copper alloy (317L-Cu), we produced 317L-Cu stainless steel with epsilon-Cu phase. The cell proliferation of osteoblasts on material surface was detected in vitro. Escherichia coli was cultured with 317L-Cu for evaluating the antibacterial activity. We found that the 317L-Cu could effectively kill the Escherichia coli on material surface. The cell proliferation of osteoblasts on material surface was not different significantly, compared with titanium material. Our study clearly demonstrated that the 317L-Cu alloys had a significant antimicrobial activity and was biocompatible in vitro, so it would be suitable to be used as a new medical material with antibacterial activity.
authors.affiliation: Department of Orthopedic Surgery, First Affiliated Hospital, China Medical University, Shenyang 11000, China.
authors.forename: Junlin
authors.initials: J
authors.lastname: Guan
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Yuping
authors.initials: Y
authors.lastname: Fu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Chai
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D010006:Osteoblasts / Q000166:cytology; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D013193:Stainless Steel / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D013193:Stainless Steel; D003300:Copper