title: Sequelae and survivorship in patients treated with (131)I-MIBG therapy.
abstract: BACKGROUND
  (131)I-meta-iodobenzylguanidine ((131)I-MIBG) has been in therapeutic use since 1980s. Newer treatment modalities are emerging for neuroendocrine tumours (NETs) and chromaffin cell tumours (CCTs), but many of these do not yet have adequate long-term follow-up to determine their longer term efficacy and sequelae.
  
  
  METHODS
  Fifty-eight patients with metastatic NETs and CCTs who had received (131)I-MIBG therapy between 2000 and 2011 were analysed. Survival and any long-term haematological or renal sequelae were investigated.
  
  
  RESULTS
  In the NET group, the overall median survival and median survival following the diagnosis of metastatic disease was 124 months. The median survival following the commencement of (131)I-MIBG was 66 months. For the CCT group, median survival had not been reached. The 5-year survival from diagnosis and following the diagnosis of metastatic disease was 67% and 67.5% for NETs and CCTs, respectively. The 5-year survival following the commencement of (131)I-MIBG therapy was 68%. Thirty-two patients had long-term haematological sequelae: 5 of these 32 patients developed haematological malignancies. Two patients developed a mild deterioration in renal function.
  
  
  CONCLUSIONS
  Long follow up of (131)I-MIBG therapy reveals a noteable rate of bone marrow toxicities and malignancy and long term review of all patients receiving radionuclide therapies is recommended.
authors.affiliation: Department of Endocrinology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
authors.forename: W C C
authors.initials: WC
authors.lastname: Sze
authors.forename: A B
authors.initials: AB
authors.lastname: Grossman
authors.forename: I
authors.initials: I
authors.lastname: Goddard
authors.forename: D
authors.initials: D
authors.lastname: Amendra
authors.forename: S C C
authors.initials: SC
authors.lastname: Shieh
authors.forename: P N
authors.initials: PN
authors.lastname: Plowman
authors.forename: W M
authors.initials: WM
authors.lastname: Drake
authors.forename: S A
authors.initials: SA
authors.lastname: Akker
authors.forename: M R
authors.initials: MR
authors.lastname: Druce
mesh_terms: D019797:3-Iodobenzylguanidine / Q000009:adverse effects / Q000627:therapeutic use*; D000310:Adrenal Gland Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D000328:Adult; D019439:Chromaffin Cells / Q000473:pathology* / Q000528:radiation effects*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000532:radiotherapy*; D019275:Radiopharmaceuticals / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine