title: Inversion-mediated gene fusions involving NAB2-STAT6 in an unusual malignant meningioma.
abstract: BACKGROUND
  Meningiomas are the most common primary intracranial tumours, with ∼3% meeting current histopathologic criteria for malignancy.
  
  
  METHODS
  In this study, we explored the transcriptome of meningiomas using RNA-Seq.
  
  
  RESULTS
  Inversion-mediated fusions between two adjacent genes, NAB2 and STAT6, were detected in one malignant tumour, creating two novel in-frame transcripts that were validated by RT-PCR and Sanger sequencing.
  
  
  CONCLUSIONS
  Gene fusions of NAB2-STAT6 were recently implicated in the pathogenesis of solitary fibrous tumours; our study suggested that similar fusions may also have a role in a malignant meningioma with unusual histopathologic features.
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.forename: C
authors.initials: C
authors.lastname: Ling
authors.forename: L
authors.initials: L
authors.lastname: Shi
authors.forename: D
authors.initials: D
authors.lastname: Commins
authors.forename: G
authors.initials: G
authors.lastname: Zada
authors.forename: W J
authors.initials: WJ
authors.lastname: Mack
authors.forename: K
authors.initials: K
authors.lastname: Wang
mesh_terms: D007446:Chromosome Inversion / Q000235:genetics*; D050939:Gene Fusion / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008577:Meningeal Neoplasms / Q000235:genetics*; D008579:Meningioma / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D050800:STAT6 Transcription Factor / Q000235:genetics*; D017423:Sequence Analysis, RNA
chemical_list: C491000:NAB2 protein, human; D012097:Repressor Proteins; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human