title: Genome-wide linkage analysis of carotid artery lumen diameter: the strong heart family study.
abstract: BACKGROUND
  A significant proportion of the variability in carotid artery lumen diameter is attributable to genetic factors.
  
  
  METHODS
  Carotid ultrasonography and genotyping were performed in the 3300 American Indian participants in the Strong Heart Family Study (SHFS) to identify chromosomal regions harboring novel genes associated with inter-individual variation in carotid artery lumen diameter. Genome-wide linkage analysis was conducted using standard variance component linkage methods, implemented in SOLAR, based on multipoint identity-by-descent matrices.
  
  
  RESULTS
  Genome-wide linkage analysis revealed a significant evidence for linkage for a locus for left carotid artery diastolic and systolic lumen diameters in Arizona SHFS participants on chromosome 7 at 120 cM (lod = 4.85 and 3.77, respectively, after sex and age adjustment, and lod = 3.12 and 2.72, respectively, after adjustment for sex, age, height, weight, systolic and diastolic blood pressure, diabetes mellitus and current smoking). Other regions with suggestive evidence of linkage for left carotid artery diastolic and systolic lumen diameter were found on chromosome 12 at 153 cM (lod = 2.20 and 2.60, respectively, after sex and age adjustment, and lod = 2.44 and 2.16, respectively, after full covariate adjustment) in Oklahoma SHFS participants; suggestive linkage for right carotid artery diastolic and systolic lumen diameter was found on chromosome 9 at 154 cM (lod = 2.72 and 3.19, respectively after sex and age adjustment, and lod = 2.36 and 2.21, respectively, after full covariate adjustment) in Oklahoma SHFS participants.
  
  
  CONCLUSIONS
  We found significant evidence for loci influencing carotid artery lumen diameter on chromosome 7q and suggestive linkage on chromosomes 12q and 9q.
authors.affiliation: Bronx-Lebanon Hospital Center, Bronx, NY, United States; Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address: jonnbella@earthlink.net.
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Bella
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Cole
authors.forename: Sandy
authors.initials: S
authors.lastname: Laston
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.forename: Anthony
authors.initials: A
authors.lastname: Comuzzie
authors.forename: Elisa T
authors.initials: ET
authors.lastname: Lee
authors.forename: Lyle G
authors.initials: LG
authors.lastname: Best
authors.forename: Richard R
authors.initials: RR
authors.lastname: Fabsitz
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.forename: Jean W
authors.initials: JW
authors.lastname: Maccluer
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Roman
authors.forename: Richard B
authors.initials: RB
authors.lastname: Devereux
authors.forename: Harald H H
authors.initials: HH
authors.lastname: Göring
mesh_terms: D000328:Adult; D001130:Arizona / Q000208:ethnology; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000235:genetics*; D015331:Cohort Studies; D005190:Family / Q000208:ethnology; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D007198:Indians, North American / Q000208:ethnology; D008297:Male; D009658:North Dakota / Q000208:ethnology; D009825:Oklahoma / Q000208:ethnology; D011446:Prospective Studies; D013023:South Dakota / Q000208:ethnology; D014463:Ultrasonography
keywords: Carotid artery; Genetics; Linkage analysis; Ultrasonography; Variance components