title: Phase II study on breast conservative surgery plus chemo- and radiotherapy in treating Chinese patients with early staged breast cancer.
abstract: OBJECTIVE
  To evaluate the efficacy of conservative surgery plus chemo-, radio-therapy in treating patients with early stage breast cancer.
  
  
  METHODS
  Eligible patients were treated by postoperative chemotherapy as well as whole-breast irradiation with tumor bed boost. Postoperative radiotherapy consisted of 6 MV whole breast linear accelerator irradiation with two tangential half fields to a total dose of 45~50 Gy, followed by 10~15 MeVβ boost irradiation to tumor bed for 10~20 Gy, total dose 56~66 Gy.
  
  
  RESULTS
  Fifty-two patients were enrolled. Overall 1-, 2- and 3 year survival rates were 98.1%, 92.3%, and 90.4%, respectively, with a local recurrence rate of 5.77%. Cosmetic results were evaluated as good by doctors in 90.4% of patients.
  
  
  CONCLUSIONS
  Breast conservative surgery combined with chemo- radio-therapy could be a treatment option for Chinese patients with early stage breast cancer.
authors.affiliation: Department of Radiation Oncology, The People's Hospital of Taixing City, Taixing, China.
authors.forename: Yang-Chen
authors.initials: YC
authors.lastname: Liu
authors.forename: Shao-Bing
authors.initials: SB
authors.lastname: Zhou
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.forename: Xiao-Xiang
authors.initials: XX
authors.lastname: Yin
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xin-En
authors.initials: XE
authors.lastname: Huang
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D018275:Carcinoma, Lobular / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate