title: Arterial stiffness evaluation by cardio-ankle vascular index in hypertension and diabetes mellitus subjects.
abstract: Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. In the present study, we investigated the possible risk factors involving CAVI in hypertension and diabetes mellitus (DM) subjects. One thousand sixty-three subjects (M/F 533/530) from Shougang Corporation Examination Center were divided into four groups: healthy group (n = 639); hypertension group (n = 312); DM group (n = 58); and hypertension with DM group (n = 54). CAVI was measured by VS-1000 apparatus. Our results showed that CAVI was significantly higher in hypertension subjects with DM than in healthy and hypertension group, respectively (8.59 ± 1.08 vs 7.23 ± 1.10; 8.59 ± 1.08 vs 7.94 ± 1.33; both P < .05). CAVI was positively correlated with age, systolic blood pressure, diastolic blood pressure, pulse pressure, fasting plasma glucose, HbA1c, uric acid, total cholesterol, triglycerides in the entire group (r = 0.633, 0.280, 0.172, 0.269, 0.209, 0.254, 0.176, 0.129, 0.175; all P < .05, respectively). There was negatively correlation between CAVI and high-density lipoprotein cholesterol in the entire group (r = -0.167; P < .05). Multivariate analysis showed that age, body mass index, HbA1c, and high-density lipoprotein cholesterol were independent associating factors of CAVI in all subjects (β = 0.699; P < .001, β = -0.189; P = .001, β = 0.144; P = .015, β = -0.136; P = .019, respectively). Our present study suggested that CAVI was significantly higher in hypertension subjects with DM compared with healthy and hypertension groups.
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, Peoples' Republic of China. Electronic address: hongyuwang@188.com.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, Peoples' Republic of China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, Peoples' Republic of China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, Peoples' Republic of China.
authors.forename: Xiaobao
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, Peoples' Republic of China.
authors.forename: Guangyun
authors.initials: G
authors.lastname: Shang
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, Peoples' Republic of China.
authors.forename: Yingyan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, Peoples' Republic of China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, Peoples' Republic of China.
authors.forename: Xujing
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, Peoples' Republic of China.
authors.forename: Guang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, Peoples' Republic of China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Shi
mesh_terms: D000328:Adult; D000842:Ankle / Q000098:blood supply; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000378:metabolism; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin; D014280:Triglycerides; D014527:Uric Acid; C517652:hemoglobin A1c protein, human
keywords: Cardio-ankle vascular index; diabetes mellitus; hypertension