title: Auditory post-processing in a passive listening task is deficient in Alzheimer's disease.
abstract: OBJECTIVE
  To investigate whether automatic auditory post-processing is deficient in patients with Alzheimer's disease and is related to sensory gating.
  
  
  METHODS
  Event-related potentials were recorded during a passive listening task to examine the automatic transient storage of auditory information (short click pairs). Patients with Alzheimer's disease were compared to a healthy age-matched control group. A young healthy control group was included to assess effects of physiological aging.
  
  
  RESULTS
  A bilateral frontal negativity in combination with deep temporal positivity occurring 500 ms after stimulus offset was reduced in patients with Alzheimer's disease, but was unaffected by physiological aging. Its amplitude correlated with short-term memory capacity, but was independent of sensory gating in healthy elderly controls. Source analysis revealed a dipole pair in the anterior temporal lobes.
  
  
  CONCLUSIONS
  Results suggest that auditory post-processing is deficient in Alzheimer's disease, but is not typically related to sensory gating. The deficit could neither be explained by physiological aging nor by problems in earlier stages of auditory perception. Correlations with short-term memory capacity and executive control tasks suggested an association with memory encoding and/or overall cognitive control deficits.
  
  
  CONCLUSIONS
  An auditory late negative wave could represent a marker of auditory working memory encoding deficits in Alzheimer's disease.
authors.affiliation: Section for Clinical Neurophysiology and Multimodal Neuroimaging, Department of Child and Adolescent Psychiatry, Technical University Dresden, Fetscherstraße 74, D-01307 Dresden, Germany; Section for Experimental Psychopathology, Psychiatric Hospital, University of Heidelberg, Voßstraße 4, D-69115 Heidelberg, Germany; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt/Main, Deutschordenstraße 50, D-60528 Frankfurt/Main, Germany. Electronic address: Stephan.Bender@uniklinikum-dresden.de.
authors.forename: Stephan
authors.initials: S
authors.lastname: Bender
authors.affiliation: Section for Clinical Neurophysiology and Multimodal Neuroimaging, Department of Child and Adolescent Psychiatry, Technical University Dresden, Fetscherstraße 74, D-01307 Dresden, Germany.
authors.forename: Annet
authors.initials: A
authors.lastname: Bluschke
authors.affiliation: Section for Clinical Neurophysiology and Multimodal Neuroimaging, Department of Child and Adolescent Psychiatry, Technical University Dresden, Fetscherstraße 74, D-01307 Dresden, Germany.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dippel
authors.affiliation: Section for Biomagnetism, Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 120, D-69120 Heidelberg, Germany.
authors.forename: André
authors.initials: A
authors.lastname: Rupp
authors.affiliation: Section for Experimental Psychopathology, Psychiatric Hospital, University of Heidelberg, Voßstraße 4, D-69115 Heidelberg, Germany; Psychiatric Hospital (SRH), Guttmannstrasse 1, D-76307 Karlsbad-Langensteinbach, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Weisbrod
authors.affiliation: Section for Experimental Psychopathology, Psychiatric Hospital, University of Heidelberg, Voßstraße 4, D-69115 Heidelberg, Germany; Evangelical Hospital Bielefeld, Department of Psychiatry and Psychotherapy Bethel, Department of Geriatric Psychiatry, Bethesdaweg 12, D-33617 Bielefeld, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Thomas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D001307:Auditory Perception; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D008570:Memory, Short-Term; D008875:Middle Aged; D055139:Sensory Gating
keywords: Aging; Alzheimer’s disease; Auditory evoked potential; Sensory gating; Source analysis; Working memory