title: Acute myeloid leukaemia with mutated NPM1 presenting with extensive bone marrow necrosis and Charcot-Leyden crystals.
abstract: Here, we report an unusual case of acute myeloid leukaemia with mutated NPM1 presenting with pancytopenia and leukoerythroblastosis, without circulating blasts and bone marrow necrosis with numerous Charcot-Leyden crystals, but no eosinophilia.
authors.affiliation: Department of Haematology, Aberdeen Royal Infirmary, Aberdeen, UK, gordon.taylor1@nhs.net.
authors.forename: Gordon
authors.initials: G
authors.lastname: Taylor
authors.forename: Adam
authors.initials: A
authors.lastname: Ivey
authors.forename: Benedict
authors.initials: B
authors.lastname: Milner
authors.forename: David
authors.initials: D
authors.lastname: Grimwade
authors.forename: Dominic
authors.initials: D
authors.lastname: Culligan
mesh_terms: D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology*; D003460:Crystallization; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D008245:Lysophospholipase / Q000378:metabolism*; D008875:Middle Aged; D009154:Mutation; D009336:Necrosis; D009687:Nuclear Proteins / Q000235:genetics*; D000090243:Nucleophosmin
chemical_list: C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D000090243:Nucleophosmin; D008245:Lysophospholipase