title: Animal models and measures of perceptual processing in schizophrenia.
abstract: This paper summarizes the discussions regarding animal paradigms for assessing perception at the seventh meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS). A breakout group at the meeting addressed candidate tests in animals that might best parallel the human paradigms selected previously in the CNTRICS program to assess two constructs in the domain of perception: gain control and visual integration. The perception breakout group evaluated the degree to which each of the nominated tasks met pre-specified criteria: comparability of tasks across multiple species; construct validity; neuroanatomical homology between species; and dynamic range across parametric variation.
authors.affiliation: Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, United States. Electronic address: siegels@upenn.edu.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Siegel
authors.forename: John C
authors.initials: JC
authors.lastname: Talpos
authors.forename: Mark A
authors.initials: MA
authors.lastname: Geyer
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D007266:Inhibition, Psychological; D017711:Nonlinear Dynamics; D010468:Perceptual Disorders / Q000175:diagnosis* / Q000209:etiology*; D010775:Photic Stimulation; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000150:complications*
keywords: Event related potentials; Mismatch negative; Prepulse inhibition of startle; Visual integration