title: Hydrothermal synthesis of hydroxyapatite plates prepared using low molecular weight heparin (LMWH).
abstract: Materials with enhanced physical and biological properties have been used for biomedical applications and can be developed by functionalizing them using various components. Hydroxyapatite (HAP), among other available synthetic material, serves as one of the best tools in orthopaedics and ceramic coatings. The porous structure of HAP helps in bone cell regeneration, chemical integration of bone and also favours the interaction between bone and tissues. Herein, we have demonstrated a simple procedure for the synthesis of HAP using low molecular weight heparin (LMWH), a structural analogue of bone heparan sulphate proteoglycan. The presence of small sized HAP plates with well-defined structures was revealed using electron microscopic analysis. The phase purity of the synthesized HAP was evaluated using X-ray diffraction pattern obtained before and after immersion in simulated body fluid (SBF).
authors.affiliation: Department of Biochemistry, Sathyabama University Dental College and Hospital, Chennai 600119, India. Electronic address: rajeearjunan@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Rajeswari
authors.affiliation: Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600119, India.
authors.forename: V Ganesh
authors.initials: VG
authors.lastname: Kumar
authors.affiliation: Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600119, India.
authors.forename: V
authors.initials: V
authors.lastname: Karthick
authors.affiliation: Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600119, India.
authors.forename: T Stalin
authors.initials: TS
authors.lastname: Dhas
authors.affiliation: Department of Biosciences, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, United Kingdom.
authors.forename: Sri Lakshmi
authors.initials: SL
authors.lastname: Potluri
mesh_terms: D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry; D006495:Heparin, Low-Molecular-Weight / Q000737:chemistry*; D011208:Powders; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D006495:Heparin, Low-Molecular-Weight; D011208:Powders; D014867:Water; D017886:Durapatite
keywords: Diffraction; Electron microscopy; Hydroxyapatite; Low molecular weight heparin and plasma