title: J wave is associated with increased risk of sudden cardiac arrest in patients with hypertrophic cardiomyopathy.
abstract: OBJECTIVE
  A retrospective, case-control study to investigate the J wave, a J-point elevation on resting 12-lead electrocardiograms, as a risk factor for sudden cardiac arrest (SCA) in patients diagnosed with hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  Patients with HCM and age- and sex-matched healthy control subjects were recruited, and 12-lead electrocardiograms were performed. The prevalence and related characteristics of J waves were assessed. Patients were followed-up for a mean of 47.9 months.
  
  
  RESULTS
  Patients with HCM (n = 345) had significantly higher prevalence of J waves than healthy controls (n = 690; 11.6% and 7.1%, respectively). During follow-up, 14 patients with HCM experienced SCA (SCA subgroup). The prevalence of J waves was significantly higher in the SCA subgroup than in the non-SCA subgroup (42.9% and 10.3%, respectively). There were no significant differences between the SCA and non-SCA subgroups in J wave morphology.
  
  
  CONCLUSIONS
  The J wave may be a risk factor for SCA in patients with HCM.
authors.affiliation: Heart Centre, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Mao
authors.forename: Qian
authors.initials: Q
authors.lastname: Yan
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Qi
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liu
authors.forename: Chen
authors.initials: C
authors.lastname: Tan
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Shi
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Wu
authors.forename: Yujie
authors.initials: Y
authors.lastname: Zeng
authors.forename: Jiyun
authors.initials: J
authors.lastname: Wang
authors.forename: Jianmin
authors.initials: J
authors.lastname: Chu
authors.forename: Changsheng
authors.initials: C
authors.lastname: Ma
authors.forename: Xingpeng
authors.initials: X
authors.lastname: Liu
authors.forename: Xinchun
authors.initials: X
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D016022:Case-Control Studies; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004562:Electrocardiography / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Hypertrophic cardiomyopathy; J wave; J-point elevation; sudden cardiac arrest; sudden cardiac death; ventricular fibrillation; ventricular tachycardia