title: Elevated platelet expression of CD36 may contribute to increased risk of thrombo-embolism in active inflammatory bowel disease.
abstract: BACKGROUND
  Inflammatory bowel disease (IBD) induces increased risk of thrombo-embolism. CD36 is involved in platelet activation, glucose metabolism and inflammation.
  
  
  OBJECTIVE
  The relationship between CD36 expression on platelets and monocytes, plasma sCD36, and CD36-positive platelet-derived microparticles (PDMPs) and inflammation in both active IBD and after one week of anti-tumour necrosis alpha antibody (anti-TNF) treatment was investigated.
  
  
  METHODS
  Patients with exacerbation of Crohn's disease (n = 8) or ulcerative colitis (n = 5) and 13 healthy controls were enrolled. Seven patients underwent anti-TNF treatment for one week. Platelet, monocyte, and PDMP-CD36 were measured by flow-cytometry.
  
  
  RESULTS
  Platelet CD36 expression was 34% higher in patients, and correlated with insulin resistance and fasting glucose. sCD36 was 37% lower and restored after anti-TNF treatment.
  
  
  CONCLUSIONS
  Elevated platelet CD36 expression may contribute to increased risk of thrombo-embolism in active IBD. This may not entirely be attributed to inflammation and secondary insulin resistance may play a role.
authors.affiliation: Department of Clinical Biochemistry, Aarhus University Hospital , Aarhus , Denmark .
authors.forename: Peter
authors.initials: P
authors.lastname: Wilhelmsen
authors.forename: Jens
authors.initials: J
authors.lastname: Kjær
authors.forename: Karen Louise
authors.initials: KL
authors.lastname: Thomsen
authors.forename: Christoffer Tandrup
authors.initials: CT
authors.lastname: Nielsen
authors.forename: Anders
authors.initials: A
authors.lastname: Dige
authors.forename: Maciej Bogdan
authors.initials: MB
authors.lastname: Maniecki
authors.forename: Niels
authors.initials: N
authors.lastname: Heegaard
authors.forename: Henning
authors.initials: H
authors.lastname: Grønbæk
authors.forename: Jens
authors.initials: J
authors.lastname: Dahlerup
authors.forename: Aase
authors.initials: A
authors.lastname: Handberg
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D018955:CD36 Antigens / Q000097:blood* / Q000737:chemistry; D003093:Colitis, Ulcerative / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D012306:Risk; D012995:Solubility; D013923:Thromboembolism / Q000097:blood* / Q000150:complications*
chemical_list: D000893:Anti-Inflammatory Agents; D018955:CD36 Antigens; D005947:Glucose