title: Hepatitis C Nosode: The preparation and homeopathic pathogenetic trial.
abstract: BACKGROUND
  A double blind, randomized placebo controlled homeopathic pathogenetic trial (proving) of Hepatitis C (Hep C) nosode was conducted with the aim to introduce the new nosode in homeopathic pharmacopeia.
  
  
  METHODS
  Documentation included approval by Ethics Committee, Informed Consent Form, Laboratory investigations, safety and ethical measures. The volunteers were trained to write data in prescribed diaries and data were analyzed. A fifteen-step method was used in the preparation of Hep C nosode (genotype I and III), allowing future preparation of an identical nosode. 22 volunteers were entered, 15 received Hep C nosode in 30c potency, 7 received placebo, once a week for four weeks.
  
  
  RESULTS
  The Hep C nosode was associated with qualitatively and quantitatively distinct symptoms, which can be applied in clinical practice. A significantly higher incidence of pathogenetic effect of homeopathic medicine compared to placebo was observed. Safety was documented. The nosode produced symptoms comparable with Hep C disease.
  
  
  CONCLUSIONS
  An improved method of nosode preparation was used. A double blind, randomized placebo controlled pathogenetic trial of the Hep C nosode generated guiding symptoms, which may facilitate its prescription in practice. The nosode should be further explored for the treatment of immunologically mediated diseases, infections including Hep C, fibrotic pathology and chronic inflammatory disorders.
authors.affiliation: Life Force, 411 Krushal commercial Complex, G.M.Road, Chembur, Mumbai 400089, India. sanjivak@gmail.com
authors.forename: Rajesh
authors.initials: R
authors.lastname: Shah
mesh_terms: D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006526:Hepatitis C / Q000188:drug therapy*; D006705:Homeopathy; D006801:Humans; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D008419:Materia Medica
keywords: Double blind; Drug proving; Hepatitis C; Homeopathic pathogenetic trial; Nosode; Placebo control; Potentization; Randomization; Safety; Standardization; Symptoms