title: Late recurrence of nonseminomatous germ cell tumor successfully treated with intensity-modulated radiation therapy.
abstract: We report the case of a 41-year-old man with a late recurrence of nonseminomatous germ cell tumor, which was successfully treated with intensity-modulated radiation therapy. For the residual retrocrural tumor invading the 11th and 12th thoracic vertebrae with an abnormal level of tumor marker (α-fetoprotein: 23.2 ng/ml) after salvage chemotherapy, chemotherapy could not be continued due to its neurotoxicity, and surgery could not be performed due to the location. In this situation, intensity-modulated radiation therapy achieved a complete response of tumor marker. The patient remained in complete clinical remission after 3 years. The efficacy of radiotherapy, especially intensity-modulated radiation therapy, for a nonseminomatous germ cell tumor is discussed.
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kita
authors.forename: Masaaki
authors.initials: M
authors.lastname: Imamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Mizowaki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Norihisa
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiraoka
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000532:radiotherapy* / Q000556:secondary*; D050397:Radiotherapy, Intensity-Modulated; D012074:Remission Induction; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D013904:Thoracic Vertebrae; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins
keywords: intensity-modulated radiation therapy; late recurrence; nonseminomatous germ cell tumor