title: DUSP10 gene polymorphism and risk of colorectal cancer in the Han Chinese population.
abstract: Dual-specificity protein phosphatases (DUSP) negatively regulate members of the mitogen-activated protein kinase superfamily, which is associated with cellular proliferation and differentiation. A recent study suggests that DUSP10 is frequently upregulated in colorectal cancer (CRC). Our study aimed to assess whether DUSP10 contributes to the risk of CRC. We analyzed nine tag single nucleotide polymorphisms (tSNPs) of DUSP10 in a case-control study of Han Chinese by the χ²-test and the SHEsis software. We found that two tSNPs (rs908858, P=0.00004; rs11118838, P=0.02510) were significantly associated with CRC using the χ²-test. Using the SHEsis software, six tSNPs (rs12041033, rs17010629, rs12724393, rs12036163, rs11118838, rs12044821) were found in the same linkage disequilibrium block. Within this linkage disequilibrium block, haplotype 'CTCAAC' showed an increased risk of CRC by 42%. By global haplotype analysis, we found that the haplotype 'ACTCAACTA' may increase the risk of CRC by ∼53%; the haplotype 'GCCCACCCA' may decrease the risk by ∼46%. Our results, combined with previous studies, suggest that certain mutations in DUSP10 correlate with the incidence of CRC. Thus, the function of the DUSP10 gene product may contribute toward CRC in the Han Chinese population.
authors.affiliation: aSecond Department of General Surgery, Shaanxi Province Hospital bSchool of Life Sciences, Northwest University cNational Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Li
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Du
authors.forename: Sangmingjiu
authors.initials: S
authors.lastname: Gong
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Mao
authors.forename: Zengzhan
authors.initials: Z
authors.lastname: Gao
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Long
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.forename: Tingting
authors.initials: T
authors.lastname: Geng
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D054637:Dual-Specificity Phosphatases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D054639:Mitogen-Activated Protein Kinase Phosphatases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C120407:DUSP10 protein, human; D054639:Mitogen-Activated Protein Kinase Phosphatases; D054637:Dual-Specificity Phosphatases