title: Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA.
abstract: We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.
authors.affiliation: Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 42, 91054 Erlangen, Germany.
authors.forename: Jenny
authors.initials: J
authors.lastname: Blechinger
authors.forename: Hanna
authors.initials: H
authors.lastname: Pieper
authors.forename: Paul
authors.initials: P
authors.lastname: Marzenell
authors.forename: Larisa
authors.initials: L
authors.lastname: Kovbasyuk
authors.forename: Andrius
authors.initials: A
authors.lastname: Serva
authors.forename: Vytaute
authors.initials: V
authors.lastname: Starkuviene
authors.forename: Holger
authors.initials: H
authors.lastname: Erfle
authors.forename: Andriy
authors.initials: A
authors.lastname: Mokhir
mesh_terms: D001483:Base Sequence; D015536:Down-Regulation / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry* / Q000494:pharmacology*; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D035683:MicroRNAs; D009841:Oligonucleotides; D013267:Stilbenes