title: Update in pediatric optic neuritis.
abstract: OBJECTIVE
  Pediatric optic neuritis is an uncommon disorder with significant distinctions from its adult counterpart. Recognizing the features of this disorder and the potential association with progressive demyelinating processes is important for patients' evaluation and prognosis.
  
  
  RESULTS
  In the last few years, studies have expanded our understanding of demographic and presenting features for optic neuritis in the pediatric population. Emerging research on biomarkers and optical coherence tomography utility offers potential prognostic value in patient management. In addition, pooled research data have allowed for better understanding of the risks factors for progression from isolated optic neuritis to systemic demyelinating processes, such as multiple sclerosis. Although definitive evidence is lacking, corticosteroids remain the cornerstone of treatment. Various other immunosuppressive therapy studies have also reported success, particularly in refractory cases.
  
  
  CONCLUSIONS
  A comprehensive understanding of pediatric optic neuritis and its management remains elusive. A randomized clinical trial would potentially increase our knowledge and benefit the afflicted patients.
authors.affiliation: Department of Pediatric Ophthalmology and Adult Strabismus, Indiana University Health, Indianapolis, Indiana, USA. janine.collinge@gmail.com
authors.forename: Janine E
authors.initials: JE
authors.lastname: Collinge
authors.forename: Derek T
authors.initials: DT
authors.lastname: Sprunger
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009902:Optic Neuritis / Q000150:complications / Q000175:diagnosis / Q000628:therapy