title: Serum and cerebrospinal fluid light neurofilaments and antibodies against them in clinically isolated syndrome and multiple sclerosis.
abstract: A release of light neurofilament subunits (NFL) into cerebrospinal fluid (CSF) and serum in multiple sclerosis (MS) may induce an immune response. We examined CSF and serum NFL levels and IgG antibodies against NFL in 19 patients with a clinically isolated syndrome (CIS) early converted into MS, 20 CIS-non-converters, 23 MS patients and 32 controls. CSF NFL levels were significantly higher in all patient groups. The highest CSF or intrathecally (IT) synthesized anti-NFL antibodies and CSF/serum ratios of anti-NFL antibodies were observed in CIS-converters. CSF NFL and CSF or IT anti-NFL antibodies could be surrogate biomarkers of axonal injury in early MS.
authors.affiliation: Charles University in Prague, First Faculty of Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Kateřinská 32, 121 08 Prague 2, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Fialová
authors.forename: Ales
authors.initials: A
authors.lastname: Bartos
authors.forename: Jana
authors.initials: J
authors.lastname: Svarcová
authors.forename: Denisa
authors.initials: D
authors.lastname: Zimova
authors.forename: Jolana
authors.initials: J
authors.lastname: Kotoucova
authors.forename: Ivan
authors.initials: I
authors.lastname: Malbohan
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D001369:Axons / Q000473:pathology; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D003711:Demyelinating Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D016900:Neurofilament Proteins / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D062706:Prodromal Symptoms; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D016900:Neurofilament Proteins; C044882:neurofilament protein L
keywords: Antibody; Cerebrospinal fluid; Clinically isolated syndrome; Light neurofilament subunit; Multiple sclerosis; Serum