title: Synthetic glycopolypeptides as biomimetic analogues of natural glycoproteins.
abstract: Glycoproteins are naturally produced by protein glycosylation and are involved in a wide range of cellular functions. This Review aims to summarize the preparation of well-defined synthetic glycoproteins by using chemical routes as well as to highlight the preparation of ideal polymeric analogues of natural glycoproteins: glycopolypeptides. These macromolecules are simplified models of glycoproteins and are designed with the purpose of both mimicking the properties of natural glycoproteins as well as bringing innovative polymeric structures for materials science applications.
authors.affiliation: Université de Bordeaux /IPB, ENSCBP, 16 avenue Pey Berland, 33607 Pessac Cedex, France.
authors.forename: Colin
authors.initials: C
authors.lastname: Bonduelle
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lecommandoux
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D055162:Biocatalysis; D006020:Glycopeptides / Q000096:biosynthesis / Q000138:chemical synthesis*; D006023:Glycoproteins / Q000737:chemistry*; D006031:Glycosylation; D006801:Humans; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000737:chemistry; D058105:Polymerization; D060327:Solid-Phase Synthesis Techniques
chemical_list: D006020:Glycopeptides; D006023:Glycoproteins