title: Use of quantitative diffusion-weighted magnetic resonance imaging to predict human papilloma virus status in patients with oropharyngeal squamous cell carcinoma.
abstract: Although identification of human papilloma virus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC) is essential in predicting treatment response, no imaging modality can currently determine whether a tumor is HPV-related. In this retrospective study, 26 patients with OPSCC confined to the lateral wall or the base of tongue underwent neck magnetic resonance imaging, using T1-, T2- and diffusion-weighted imaging (DWI). Apparent diffusion coefficients (ADCs) in a region of interest covering the largest available primary tumor area of OPSCC on a single slice of the ADC map were calculated using two b values (0 and 1,000 s/mm(2)). Mean and minimum ADCs were compared with HPV status, using p16 immunohistochemistry as a surrogate marker for HPV infection. Mean and minimum ADCs for HPV(+) OPSCC were significantly lower than those for HPV(-) OPSCC. A cut-off value of mean ADC for HPV(+) OPSCC of 1.027 × 10(-3) mm(2)/s yielded sensitivity and specificity of 83.33 and 78.57%, respectively. In conclusion, the present study indicates that ADC could be used to predict HPV status in patients with OPSCC.
authors.affiliation: Department of Head and Neck Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan, nakahiratosa59@yahoo.co.jp.
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Nakahira
authors.forename: Naoko
authors.initials: N
authors.lastname: Saito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Kuba
authors.forename: Masashi
authors.initials: M
authors.lastname: Sugasawa
mesh_terms: D000368:Aged; D015415:Biomarkers; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D052162:Human papillomavirus 16; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014059:Tongue / Q000473:pathology / Q000821:virology; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000821:virology
chemical_list: D015415:Biomarkers