title: [Gene of glucocorticoid receptor: structure, polymorphism and clinical associations].
abstract: The article provides modern information about the structure of glucocorticoid receptor gene and its isoforms, the most common variants of missens and allelic polymorphisms. The polymorphisms N363S, BclI, ER22/23EK and TthIIII were characterized. The relationship of these polymorphisms with physique and metabolic changes, cardiovascular system diseases as well as with sensitivity to glucocorticoids (GCS) was analyzed. It has been established that N363S and BclI polymorphisms are associated with hypersensitivity to corticosteroids and can be the predictors of obesity, metabolic syndrome, and polymorphisms ER22/23EK and TthIIII are associated with resistance to GC and favorable metabolic profile.
authors.forename: L N
authors.initials: LN
authors.lastname: Pristupa
authors.forename: V V
authors.initials: VV
authors.lastname: Kmyta
authors.forename: O V
authors.initials: OV
authors.lastname: Savchenko
mesh_terms: D004247:DNA / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011965:Receptors, Glucocorticoid / Q000235:genetics* / Q000378:metabolism
chemical_list: D011965:Receptors, Glucocorticoid; D004247:DNA