title: Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease.
abstract: OBJECTIVE
  Omentin-1 is suggested to affect inversely atherosclerosis (AS). Data about omentin-1 is limited to chronic kidney disease (CKD). Our aim was to examine omentin-1 in non-diabetic CKD patients who are not dialyzed and investigate its relationships with inflammation and carotid AS.
  
  
  METHODS
  We performed a cross-sectional study in 55 non-diabetic CKD patients and 30 healthy controls. Baseline clinical and laboratory data were obtained for all participants. Serum omentin-1 and interleukin-6 (IL-6) levels were measured according to the manufacturer's instructions. Carotic plaque and intima-media thickness (IMT) were assessed by carotid ultrasonography. The homeostasis model assessment of insulin resistance index (HOMA-IR) was used to assess IR.
  
  
  RESULTS
  Omentin-1 and IL-6 levels in the patient group were found to be higher than the control group; the differences were statistically significant (p = 0.01 and p = 0.04, respectively). Carotid IMT(mean) was significantly higher in the patient group (p = 0.01). Omentin-1 did not correlate with IL-6 and IMT in the patient group (p = 0.51 and p = 0.76, respectively). In subgroup analysis, omentin-1 levels in patients with carotid plaque were lower than those without carotid plaque (179.5 ± 88.1 ng/ml and 185.9 ± 67.8 ng/ml, respectively). However, the difference was not statistically significant (p = 0.47).
  
  
  CONCLUSIONS
  We conclude that omentin-1 is higher in not dialyzed non-diabetic CKD and there is no correlation between omentin-1 and IL-6 or carotid IMT(mean).
authors.affiliation: Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey. dr.erkansengul@hotmail.com
authors.forename: Erkan
authors.initials: E
authors.lastname: Sengul
authors.forename: Gokhan
authors.initials: G
authors.lastname: Duygulu
authors.forename: Sevim
authors.initials: S
authors.lastname: Dindar
authors.forename: Fatih
authors.initials: F
authors.lastname: Bunul
mesh_terms: D000328:Adult; D002340:Carotid Artery Diseases / Q000097:blood* / Q000150:complications; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D015850:Interleukin-6; D037102:Lectins