title: A new triterpenoid saponin from Ardisia gigantifolia.
abstract: A new triterpenoid saponin, named 3-O-β-d-glucopyranosyl-(1 → 3)-β-d-xylopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 3)]-β-d-glucopyranosyl-(1 → 4)-[β-d-glucopyranosyl-(1 → 2)]-α-l-arabinopyranosyl-3β,16α,28,30-tetrahydroxy-olean-12-ene (1), along with four known triterpenoids (2-5), was isolated from the rhizomes of Ardisia gigantifolia. Their structures were elucidated by spectroscopic methods. Compounds 1-4 showed cytotoxic activity against Hela, EJ, BCG, and HepG-2 cell lines. The percentage of early apoptotic cells after treatment with 1 was significantly increased compared with control cells (p < 0.05).
authors.affiliation: a Department of Clinical Pharmacology , General Hospital of PLA , Beijing , 100853 , China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Mu
authors.forename: Xiao-Wu
authors.initials: XW
authors.lastname: Huang
authors.forename: Dai-Hong
authors.initials: DH
authors.lastname: Guo
authors.forename: Xian-Zhe
authors.initials: XZ
authors.lastname: Dong
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031644:Ardisia / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C585875:3-O-beta-D-glucopyranosyl-(1-3)-beta-D-xylopyranosyl-(1-2)-(alpha-L-rhamnopyranosyl-(1-3))-beta-D-glucopyranosyl-(1-4)-(beta-D-glucopyranosyl-(1-2))-alpha-L-arabinopyranosyl-3beta,16alpha,28,30-tetrahydroxy-olean-12-ene; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D009828:Oleanolic Acid