title: Oral administration of alkylglycerols differentially modulates high-fat diet-induced obesity and insulin resistance in mice.
abstract: Alkylglycerols (AKGs) from shark liver oil (SLO) were demonstrated to have strong potency to stimulate immune response. However, no study has been conducted on the effects of AKGs on diet-induced obesity and metabolic inflammatory disorder. The purpose of the present study was to investigate the effect of two AKGs isoforms on obesity and insulin resistance in mice fed high-fat (HF) diet. Forty-eight C57BL/6 mice were divided into normal, HF, HF + 20 mg/kg selachyl alcohol (SA), HF + 200 mg/kg SA, HF + 20 mg/kg batyl alcohol (BA), and HF + 200 mg/kg BA groups. Body weight, fasting glucose, lipids, insulin and leptin levels, serum IL-1β, and TNF- α levels were compared among different groups. Our results showed that high-dose SA decreased body weight, serum triglyceride, cholesterol, fasting glucose level, insulin level, and serum leptin level of the HF fed mice, while high-dose BA increased fasting insulin level of the HF fed mice. Pretreatment of primary adipocytes with 10  μ M SA or BA differentially modulates LPS-mediated MAPK and NF- κ B signaling. Our study demonstrated that oral administration of AKGs has differential effects on HF-induced obesity and metabolic inflammatory disorder in mice.
authors.affiliation: Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, China ; Department of Immunology, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Mingshun
authors.initials: M
authors.lastname: Zhang
authors.forename: Shuna
authors.initials: S
authors.lastname: Sun
authors.forename: Ning
authors.initials: N
authors.lastname: Tang
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
authors.forename: Linxi
authors.initials: L
authors.lastname: Qian