title: Elevated diastolic blood pressure in insulin-resistant polycystic ovarian syndrome patients.
abstract: OBJECTIVE
  The purpose of this study was to further understand interrelationships between insulin resistance in PCOS and elevated diastolic blood pressure.
  
  
  METHODS
  A prospective case control study.
  
  
  METHODS
  Fifty normal women and 43 PCOS patients, 16 of them with insulin resistance.
  
  
  METHODS
  Academic Institution.
  
  
  METHODS
  Clinical, anthropometric and ultrasonographic features of PCOS were assessed, as were blood levels for luteinizing hormone, follicle-stimulating hormone, androstenedione, DHEAS, and basal insulin. A lipid profile and an oral glucose tolerance test (OGTT) were also performed.
  
  
  METHODS
  To demonstrate the effect of insulin resistance on blood pressure in patients with PCOS.
  
  
  RESULTS
  Patients with PCOS and those with PCOS plus insulin resistance (IR) had significantly elevated levels of plasma androgen but only those with IR showed greater body mass index and waist: hip ratios than PCOS or control. PCOS plus IR differed significantly in their response to OGTT when compared to PCOS or control. Alterations in lipid profile were shown to be atherogenic. Patients with PCOS plus IR demonstrated a significant elevation of diastolic blood pressure when compared to PCOS alone or controls.
  
  
  CONCLUSIONS
  We hypothesize that hyperlipidemia and IR may be involved in the pathophysiologic features of the elevated diastolic blood pressure in PCOS patients.
authors.affiliation: Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors.forename: Angélica Maria Holanda Pascoal
authors.initials: AM
authors.lastname: da Silva
authors.forename: Ana Carolina Rodrigues
authors.initials: AC
authors.lastname: de Andrade
authors.forename: Bruno Hállan Meneses
authors.initials: BH
authors.lastname: Dias
authors.forename: Maria Angelina
authors.initials: MA
authors.lastname: da Silva Medeiros
authors.forename: Vietla Satianarayana
authors.initials: VS
authors.lastname: Rao
authors.forename: Francisco
authors.initials: F
authors.lastname: das Chagas Medeiros
mesh_terms: D000328:Adult; D000735:Androstenedione / Q000097:blood; D001786:Blood Glucose; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D016022:Case-Control Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D007328:Insulin; D000735:Androstenedione; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone