title: Warkmycin, a novel angucycline antibiotic produced by Streptomyces sp. Acta 2930*.
abstract: A novel angucycline-type antibiotic, warkmycin, was isolated from the culture filtrate of Streptomyces strain Acta 2930. Its chemical structure was elucidated by HR-MS, one-dimensional and 2D NMR experiments. The compound inhibits the growth of Gram-positive bacteria and shows a strong antiproliferative activity against mouse fibroblast cell line NIH-3T3 and human cancer cell lines HepG2 and HT29.
authors.affiliation: 1] Institut für Chemie, FG Organische Chemie, Technische Universität Berlin, Berlin, Germany [2] Department of Chemistry, Faculty of Science, Aswan University, Aswan, Egypt.
authors.forename: Soleiman E
authors.initials: SE
authors.lastname: Helaly
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.forename: Heidi
authors.initials: H
authors.lastname: Zinecker
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001551:Benz(a)Anthracenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D019073:HT29 Cells; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry; D051379:Mice; D041681:NIH 3T3 Cells; D013302:Streptomyces / Q000378:metabolism*; D014312:Trisaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001551:Benz(a)Anthracenes; D014312:Trisaccharides; C586019:warkmycin