title: Leptin and plasminogen activator inhibitor-1 levels in children on chronic dialysis.
abstract: OBJECTIVE
  In this study, it is aimed to compare the serum leptin and PAI-1 levels and evaluate their relationship in children on hemodialysis (HD) and peritoneal dialysis (PD).
  
  
  METHODS
  Thirty-six patients on HD (mean age: 15.0 ± 2.8 years), 19 patients on PD (mean age: 13.0 ± 3.5 years) and 15 healthy subjects (mean age: 14.5 ± 2.7 years) were included in the study. Laboratory investigations included blood count, biochemical parameters, serum iron, iron binding capacity, parathormone, erythrocyte sedimentation rate, C-reactive protein (CRP), prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, serum leptin and PAI-1 levels.
  
  
  RESULTS
  Serum leptin levels were significantly higher in HD group than in control group when the effects of BMI and sex were controlled, while PD and control groups had similar leptin levels. PAI-1 levels were also significantly higher in HD group than in control group, while there was no statistically significant difference in PAI-1 levels of PD and control group. PAI-1 levels and leptin levels were significantly correlated, which was independent of the effect of BMI in both HD and PD groups when they are evaluated separately.
  
  
  CONCLUSIONS
  Results of our study showed that HD patients had higher leptin and PAI-1 levels and leptin and PAI-1 levels were correlated significantly in both patient groups. The effect of elevated serum leptin and PAI-1 levels on the cardiovascular complications remains to be established.
authors.affiliation: Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey. pinaris2001@yahoo.com
authors.forename: Pinar Isik
authors.initials: PI
authors.lastname: Agras
authors.forename: Esra
authors.initials: E
authors.lastname: Baskin
authors.forename: Nurcan
authors.initials: N
authors.lastname: Cengiz
authors.forename: Aysegul
authors.initials: A
authors.lastname: Haberal
authors.forename: Namik
authors.initials: N
authors.lastname: Ozbek
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000209:etiology / Q000628:therapy*; D020738:Leptin / Q000097:blood*; D008297:Male; D010530:Peritoneal Dialysis; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1