title: A case report of acute myeloid leukemia and neurofibromatosis 1.
abstract: We report a case of a 65-year old patient affected by neurofibromatosis 1, documented by the presence of germ-line mutation on the NF1 gene, who developed various hyperproliferative malignant and benign diseases. He was brought to our attention for the diagnosis of acute myeloid leukemia revealed by major fatigue and dyspnea. The disease characteristics at diagnosis were hyperleukocytosis and complex karyotype with the inversion of the chromosome 16, classifying as a high-risk leukemia. The association between leukemia and neurofibromatosis 1 is controversial and needs to be further investigated. Nevertheless, such patients present a wide number of comorbidities that make therapeutic strategies most difficult.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Sartor
authors.forename: Cristina
authors.initials: C
authors.lastname: Papayannidis
authors.forename: Maria
authors.initials: M
authors.lastname: Chiara Abbenante
authors.forename: Antonio
authors.initials: A
authors.lastname: Curti
authors.forename: Nicola
authors.initials: N
authors.lastname: Polverelli
authors.forename: Emanuela
authors.initials: E
authors.lastname: Ottaviani
authors.forename: Ilaria
authors.initials: I
authors.lastname: Iacobucci
authors.forename: Viviana
authors.initials: V
authors.lastname: Guadagnuolo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
keywords: NF1; Von Recklinghausen disease; acute myeloid leukemia; neurofibromatosis type 1,