title: The integration of physiologically-targeted skin care in the management of atopic dermatitis: focus on the use of a cleanser and moisturizer system incorporating a ceramide precursor, filaggrin degradation products, and specific "skin-barrier-friendly" excipients.
abstract: Atopic dermatitis (AD) may be considered the "poster disease" for exemplifying the significance of abnormalities of the epidermal barrier that occur predominantly within the stratum corneum (SC) and upper epidermis. Specifically, impairments of the SC permeability barrier, antimicrobial barrier, and immunologic barrier contribute markedly to the fundamental pathophysiology of AD. The multiple clinical sequelae associated with epidermal barrier impairments inherent to AD include dry skin, pruritus, increased skin sensitivity to irritants and allergens, eczematous skin changes, staphylococcal skin and anterior nares colonization, and increase in some cutaneous infections (ie, molluscum contagiosum). This article addresses the pathophysiology of AD with clinically relevant correlations, and discusses the scientific basis of a specially designed cleanser and moisturizer system that incorporates ceramide technology and filaggrin degradation products along with other "barrier-friendly" excipients.
authors.affiliation: Valley Hospital Medical Center, Las Vegas, NV, USA. jqdelrosso@yahoo.com
authors.forename: James Q
authors.initials: JQ
authors.lastname: Del Rosso
authors.forename: Leon H
authors.initials: LH
authors.lastname: Kircik
mesh_terms: D002518:Ceramides / Q000737:chemistry*; D003876:Dermatitis, Atopic / Q000503:physiopathology / Q000628:therapy*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000737:chemistry; D004643:Emollients / Q000008:administration & dosage; D004817:Epidermis / Q000503:physiopathology; D005079:Excipients / Q000737:chemistry; D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000737:chemistry*; D017592:Skin Care / Q000379:methods*
chemical_list: D002518:Ceramides; D003879:Dermatologic Agents; D004643:Emollients; D005079:Excipients; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins