title: Use of Split Bregman denoising for iterative reconstruction in fluorescence diffuse optical tomography.
abstract: Fluorescence diffuse optical tomography (fDOT) is a noninvasive imaging technique that makes it possible to quantify the spatial distribution of fluorescent tracers in small animals. fDOT image reconstruction is commonly performed by means of iterative methods such as the algebraic reconstruction technique (ART). The useful results yielded by more advanced l1-regularized techniques for signal recovery and image reconstruction, together with the recent publication of Split Bregman (SB) procedure, led us to propose a new approach to the fDOT inverse problem, namely, ART-SB. This method alternates a cost-efficient reconstruction step (ART iteration) with a denoising filtering step based on minimization of total variation of the image using the SB method, which can be solved efficiently and quickly. We applied this method to simulated and experimental fDOT data and found that ART-SB provides substantial benefits over conventional ART.
authors.affiliation: Universidad Carlos III de Madrid, Departamento de Bioingeniería e Ingeniería Aeroespacial, 28911 Leganés, Spain. chamorro@mce.hggm.es
authors.forename: Judit
authors.initials: J
authors.lastname: Chamorro-Servent
authors.forename: Juan F P J
authors.initials: JF
authors.lastname: Abascal
authors.forename: Juan
authors.initials: J
authors.lastname: Aguirre
authors.forename: Simon
authors.initials: S
authors.lastname: Arridge
authors.forename: Teresa
authors.initials: T
authors.lastname: Correia
authors.forename: Jorge
authors.initials: J
authors.lastname: Ripoll
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Vaquero
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D061848:Optical Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D041622:Tomography, Optical / Q000379:methods*