title: [Granulosa cell tumor: difficulty of diagnosis and contribution of imaging].
abstract: Granulosa tumors (GT) are rare neoplasms, difficult to diagnose in a preoperative stage. We report a set of seven patients affected by GT admitted in Amiens University Hospital, collated with a review of the literature (n=379). Our aim was to report the clinical and radiological characteristics of GT, in order to improve preoperative diagnosis. The average age of the subjects was 50.8 years old among the bibliographical search, and 37years old for the observations reported in Amiens. The principal circumstances of diagnosis were vaginal bleeding, abdominal pain and infertility. Ultrasound was the most frequently investigation, revealing GT as a large unilateral solid and cystic mass. The computed tomodensitometry (CT) allowed to precise the locoregional extension. Magnetic Resonance Imaging (MRI) appeared to be interesting to clarify lesions, showing GT as a solid mass with a cystic component or as a multicystic mass. Hormonal assays (inhibin B and/or anti-Müllerian hormone) can provide valuable assistance in diagnosis, despite their cost and lack of availability. In view of the clinical and radiological presentation of the reported and literature review cases, we suggest hormonal assays among perimenopausal women presenting with an unusual radiological aspect of an annexial mass.
authors.affiliation: Service de gynécologie obstétrique, Amiens cedex 1, France.
authors.forename: A
authors.initials: A
authors.lastname: Mancaux
authors.forename: E
authors.initials: E
authors.lastname: Grardel Chambenoit
authors.forename: O
authors.initials: O
authors.lastname: Gagneur
authors.forename: A
authors.initials: A
authors.lastname: Nasreddine
authors.forename: J
authors.initials: J
authors.lastname: Gondry
authors.forename: P
authors.initials: P
authors.lastname: Merviel
mesh_terms: D015746:Abdominal Pain; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D003952:Diagnostic Imaging; D005260:Female; D005602:France; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000601:surgery; D006785:Hospitals, University; D006801:Humans; D007247:Infertility, Female; D007265:Inhibins / Q000097:blood; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014592:Uterine Hemorrhage
chemical_list: D014408:Biomarkers, Tumor; C422364:inhibin B; D007265:Inhibins; D054304:Anti-Mullerian Hormone
keywords: AMH; CT; Granulosa tumor; IRM; Inhibin B; Inhibine B; MRI; TDM; Tumeur de la granulosa; Ultrasound; Échographie