title: [Characteristics of JC virus VLP-Z for targeting gene delivery].
abstract: The characteristics of virus-like particle (VLP) of JC virus (JCV) as a vector for targeting gene delivery was determined. The exogenous DNA (PUC19) packaged in VLP-Z was resistant to DNase I. VLP-Z was able to deliver a reporter plasmid pEGFP-N1 into HeLa cells and the green fluorescent reporter protein was expressed in these cells. VLP-Z was also able to bind IgG by interaction with the Z fragment of VLP-Z and IgG. These results suggested that VLP-Z might be used as a vector to deliver therapeutic genes to target cells with incorporating IgG antibodies.
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Medical College of Xi 'an Jiaotong University, Xi'an 710061, China.
authors.forename: Junyan
authors.initials: J
authors.lastname: Zeng
authors.forename: Qiumin
authors.initials: Q
authors.lastname: Qu
mesh_terms: D018390:Gene Targeting / Q000379:methods*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007577:JC Virus / Q000235:genetics* / Q000378:metabolism; D014771:Virion / Q000235:genetics / Q000378:metabolism
chemical_list: D007074:Immunoglobulin G