title: Angioinvasive lymphomatoid papulosis: another case of a newly described variant.
abstract: Lymphomatoid papulosis (LyP) is a chronic recurrent lymphoproliferative disorder characterized clinically by self-regressing cutaneous lesions. Histologically, it is recognized by clusters of CD30 atypical lymphocytes in the background of mixed inflammatory infiltrate. It has been classified as type A, B, C, and D. Recently, a further variant of LyP was described as "angioinvasive LyP" in a series of 16 patients. We report a case of a 73-year-old female presenting with papules and nodules on the extremities evolving into eschar-like necrotic plaques. Histological examination revealed medium- to large-sized atypical lymphoid CD30 cells densely infiltrating the dermis with distinct angioinvasion and angiodestruction. No systemic involvement was identified. The clinicopathologic features conformed to the newly described angioinvasive LyP.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Sharaf
authors.forename: Paolo
authors.initials: P
authors.lastname: Romanelli
authors.forename: Robert
authors.initials: R
authors.lastname: Kirsner
authors.forename: Mariya
authors.initials: M
authors.lastname: Miteva
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017731:Lymphomatoid Papulosis / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor