title: Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study.
abstract: BACKGROUND
  Chronic lymphocytic leukaemia (CLL) patients have an increased risk of other malignancies. This may be due to surveillance bias, treatment or immunosuppression.
  
  
  METHODS
  Cohort study of 612 consecutively diagnosed CLL patients in a Canadian province, with comparisons to follicular lymphoma (FL) patients.
  
  
  RESULTS
  Treated CLL patients had a 1.7-fold increased risk of second cancers compared with untreated CLL patients. As compared with untreated FL patients, untreated CLL patients had a two-fold increased incidence of second malignancies.
  
  
  CONCLUSIONS
  Chronic lymphocytic leukaemia patients have an inherent predisposition to second cancers and the incidence is further increased by treatment.
authors.affiliation: Department of Biochemistry and Medical Genetics, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, MB, Canada R3E 0V9.
authors.forename: S
authors.initials: S
authors.lastname: Beiggi
authors.forename: J B
authors.initials: JB
authors.lastname: Johnston
authors.forename: M D
authors.initials: MD
authors.lastname: Seftel
authors.forename: M W
authors.initials: MW
authors.lastname: Pitz
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: V
authors.initials: V
authors.lastname: Banerji
authors.forename: E J
authors.initials: EJ
authors.lastname: Griffith
authors.forename: S B
authors.initials: SB
authors.lastname: Gibson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002170:Canada / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000453:epidemiology*; D008224:Lymphoma, Follicular / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors