title: Assessment of CASP10 contact-assisted predictions.
abstract: In CASP10, for the first time, contact-assisted structure predictions have been assessed. Sets of pairs of contacting residues from target structures were provided to predictors for a second round of prediction after the initial round in which they were given only sequences. The objective of the experiment was to measure model quality improvement resulting from the added contact information and thereby assess and help develop so-called hybrid prediction methods--methods where some experimentally determined distance constraints are used to augment de novo computational prediction methods. The results of the experiment were, overall, quite promising.
authors.affiliation: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Taylor
authors.forename: Hongjun
authors.initials: H
authors.lastname: Bai
authors.forename: Chin-Hsien
authors.initials: CH
authors.lastname: Tai
authors.forename: Byungkook
authors.initials: B
authors.lastname: Lee
mesh_terms: D019295:Computational Biology / Q000379:methods*; D008958:Models, Molecular; D015233:Models, Statistical; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment
chemical_list: D011506:Proteins
keywords: CASP10; contact assisted; hybrid prediction; protein structure prediction