title: Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?
abstract: Hepatitis C virus (HCV) is a cause of liver diseases that range from steatohepatitis, to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The challenge of understanding the pathogenesis of HCV-associated liver cancer is difficult as most standard animal models used in biomedical research are not permissive to HCV infection. Herein, we provide an overview of a number of creative in vivo, mostly in the mouse, and in vitro models that have been developed to advance our understanding of the molecular and cellular effects of HCV on the liver, specifically with their relevance to HCC.
authors.affiliation: Department of Environmental Sciences & Engineering, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: iir@unc.edu.
authors.forename: Ivan
authors.initials: I
authors.lastname: Rusyn
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Stanley M
authors.initials: SM
authors.lastname: Lemon
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D002472:Cell Transformation, Viral; D004195:Disease Models, Animal; D018450:Disease Progression; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006526:Hepatitis C / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D011379:Prognosis; D012307:Risk Factors; D015398:Signal Transduction
keywords: Cancer; Hepatitis C virus; Liver; Mechanisms; Models