title: Detection of tumor progression by signal intensity increase on fluid-attenuated inversion recovery magnetic resonance images in the resection cavity of high-grade gliomas.
abstract: Increased signal intensity (SI) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance (MR) images in the resection cavity is sometimes observed after partial resection of gliomas. SI in the resection cavity of 44 high-grade gliomas was retrospectively investigated. Twelve of 35 patients with progressive disease (PD) showed SI increase in the resection cavity, and SI increase preceded PD in 6 of these 12 patients. None of nine patients without PD showed SI increase during the follow-up period. The analysis of SI on FLAIR images in the resection cavity had a specificity of 100% and a sensitivity of 34%. Higher sensitivity was found in grade IV tumors than in grade III tumors. SI increase is thus considered as a potent highly specific hallmark for subsequent or coincident tumor progression, which is clinically useful since MR imaging is easily performed during routine clinical examinations.
authors.affiliation: Division of Neurosurgery, Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan.
authors.forename: Tae
authors.initials: T
authors.lastname: Ito-Yamashita
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakasu
authors.forename: Koichi
authors.initials: K
authors.lastname: Mitsuya
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Mizokami
authors.forename: Hiroki
authors.initials: H
authors.lastname: Namba
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D003399:Craniotomy; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D018365:Neoplasm, Residual / Q000175:diagnosis / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity