title: Synthesis, characterization, and antimicrobial activity of poly(acrylonitrile-co-methyl methacrylate) with silver nanoparticles.
abstract: Nanotechnology is expected to open some new aspects to fight and prevent diseases using atomic-scale tailoring of materials. The main aim of this study is to biosynthesize silver nanoparticles (AgNPs) using Trichoderma viride (HQ438699); the metabolite of this fungus will help either in reduction of the silver nitrate-adding active materials which will be loaded on the surface of the produced AgNPs. Poly(acrylonitrile-co-methyl methacrylate) copolymer (poly (AN-co-MMA)) was grafted with the prepared AgNPs. The poly(AN-co-MMA)/AgNPs were examined against ten different pathogenic bacterial strains, and the result was compared with another four different generic antibiotics. The produced poly(AN-co-MMA)/AgNPs showed high antibacterial activity compared with the four standard antibiotics. Moreover, the grafting of these AgNPs into the copolymer has potential application in the biomedical field.
authors.affiliation: Polymer Materials Research Department, Institute of Advanced Technology and New Material, City of Scientific Research and Technology Applications, New Borg El-Arab City, 21934, Alexandria, Egypt, mohamed_elaassar@yahoo.com.
authors.forename: M R
authors.initials: MR
authors.lastname: El-Aassar
authors.forename: Elsayed E
authors.initials: EE
authors.lastname: Hafez
authors.forename: Moustafa M G
authors.initials: MM
authors.lastname: Fouda
authors.forename: Salem S
authors.initials: SS
authors.lastname: Al-Deyab
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002437:Cefazolin / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D008768:Methylmethacrylates / Q000138:chemical synthesis / Q000627:therapeutic use*; D008795:Metronidazole; D008826:Microbial Sensitivity Tests; D008837:Micrococcus; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012834:Silver / Q000494:pharmacology* / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000187:drug effects; D014242:Trichoderma / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D008768:Methylmethacrylates; D008795:Metronidazole; D012834:Silver; D002701:Chloramphenicol; D002437:Cefazolin; D002439:Cefotaxime