title: [Thromboprophylaxis in medical patients: Which modifications with the new oral anticoagulants?].
abstract: Thromboprophylaxis with low molecular weight heparin or fondaparinux is associated with a 50% reduction in the risk of venous thrombo-embolism (VTE) in medical patients. Thromboprophylaxis is indicated in the prevention of VTE in medical patients at risk of VTE. Extended thromboprophylaxis with apixaban is associated with a greater reduction in VTE events but also with an increase in bleeding events when compared to standard therapy with enoxaparine. Extended thromboprophylaxis with rivaroxaban is associated with a greater reduction in VTE events but also with an increase in bleeding events, when compared to standard therapy with enoxaparine. Rivaroxaban and apixaban are currently not indicated in medical prophylaxis.
authors.affiliation: Université Saint-Étienne Jean-Monnet, groupe de recherche sur la thrombose (EA3065), 42023 Saint-Étienne, France; Inserm, CIE3, 42055 Saint-Étienne, France; CHU de Saint-Étienne, hôpital Nord, service de médecine et thérapeutique, avenue Albert-Raimond, 42055 Saint-Étienne, France. Electronic address: laurent.bertoletti@chu-st-etienne.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Bertoletti
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Lega
authors.forename: Sandrine
authors.initials: S
authors.lastname: Accassat
authors.forename: Adel
authors.initials: A
authors.lastname: Merah
authors.forename: Patrick
authors.initials: P
authors.lastname: Mismetti
authors.forename: Hervé
authors.initials: H
authors.lastname: Décousus
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage*; D017984:Enoxaparin / Q000008:administration & dosage; D006801:Humans; D009025:Morpholines / Q000008:administration & dosage; D011720:Pyrazoles / Q000008:administration & dosage; D011728:Pyridones / Q000008:administration & dosage; D000069552:Rivaroxaban; D013876:Thiophenes / Q000008:administration & dosage; D013923:Thromboembolism / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D009025:Morpholines; D011720:Pyrazoles; D011728:Pyridones; D013876:Thiophenes; C522181:apixaban; D000069552:Rivaroxaban