title: [Advances on effects of triptolide with non-small cell lung cancer].
abstract: Triptolide can cure a variety kinds of non-small cell lung cancer cell lines. It can interfere the cell cycle, active the caspase signaling pathway, inhibit the of expression vascular endothelial growth factor (VEGF), inhibit the activation of NF-κB, and through these ways to promote lung cancer cell death. Now the anti-tumor mechanism and effect of triptolide was summarized to provide help for scientific research and clinical applications in non-small cell lung cancer.
authors.affiliation: Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Command, Clinical School of the Medical College of Nanjing University, Nanjing 210002, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Song
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D004224:Diterpenes / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004852:Epoxy Compounds / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D010616:Phenanthrenes / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; C001899:triptolide