title: Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine.
abstract: We report two female infants with early myoclonic encephalopathy (EME) whose intractable focal seizures were suppressed with lidocaine and carbamazepine (CBZ). Although EME is a form of early-onset epileptic encephalopathy characterised by myoclonus and focal seizures that are highly resistant to treatment, lidocaine and CBZ may prove effective in treating this disorder. Future studies should be performed in order to determine whether there are common specific mechanisms of seizure generation related to the sodium channel in these patients.
authors.affiliation: Department of Pediatrics, Matsuyama Red Cross Hospital, Matsuyama.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Nakano
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Maniwa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kodani
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ohtsuka
mesh_terms: D000779:Anesthetics, Local / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D002220:Carbamazepine / Q000627:therapeutic use*; D004569:Electroencephalography; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008012:Lidocaine / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D013035:Spasm / Q000209:etiology; D013036:Spasms, Infantile / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D000927:Anticonvulsants; D002220:Carbamazepine; D008012:Lidocaine