title: Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration.
abstract: OBJECTIVE
  Starvation-induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal-weight controls and their relation with the disease duration and weight restoration.
  
  
  METHODS
  We analyzed circulating adipocytokine levels in 28 patients with AN and in 33 normal-weight controls who were eating healthily. We determined by enzyme-linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin-2 (LCN2), leptin, tumor necrosis factor receptor-II (TNFRII), interleukin-6 (IL6), adipocyte fatty acid binding protein-4 (FABP4), ghrelin, and resistin.
  
  
  RESULTS
  The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (r = -0.372, p = 0.033; r = -0.450, p = 0.038, respectively). Furthermore, the lipid binding-proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (r = 0.537, p = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (r = -0.456, p = 0.039; r = -0.536, p = 0.015, respectively).
  
  
  CONCLUSIONS
  These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration.
authors.affiliation: Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain.
authors.forename: Ximena
authors.initials: X
authors.lastname: Terra
authors.forename: Teresa
authors.initials: T
authors.lastname: Auguet
authors.forename: Zaida
authors.initials: Z
authors.lastname: Agüera
authors.forename: Isabel Maria
authors.initials: IM
authors.lastname: Quesada
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Orellana-Gavaldà
authors.forename: Carmen
authors.initials: C
authors.lastname: Aguilar
authors.forename: Susana
authors.initials: S
authors.lastname: Jiménez-Murcia
authors.forename: Alba
authors.initials: A
authors.lastname: Berlanga
authors.forename: Esther
authors.initials: E
authors.lastname: Guiu-Jurado
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Menchón
authors.forename: Fernando
authors.initials: F
authors.lastname: Fernández-Aranda
authors.forename: Cristóbal
authors.initials: C
authors.lastname: Richart
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D016022:Case-Control Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D007406:Interview, Psychological; D020738:Leptin / Q000378:metabolism; D052243:Resistin / Q000097:blood; D018570:Risk Assessment; D013030:Spain
chemical_list: D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D054439:Ghrelin; D020738:Leptin; D052243:Resistin
keywords: adipocytokines; anorexia nervosa; weight restoration