title: Replication proteins and human disease.
abstract: In this article, we discuss the significance of DNA replication proteins in human disease. There is a broad range of mutations in genes encoding replication proteins, which result in several distinct clinical disorders that share common themes. One group of replication proteins, the MCMs, has emerged as effective biomarkers for early detection of a range of common cancers. They offer practical and theoretical advantages over other replication proteins and have been developed for widespread clinical use.
authors.affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Jackson
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Laskey
authors.forename: Nicholas
authors.initials: N
authors.lastname: Coleman
mesh_terms: D018797:Cell Cycle Proteins / Q000502:physiology*; D000074002:DNA Polymerase gamma; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology
chemical_list: D018797:Cell Cycle Proteins; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase