title: Hepatitis C virus reinfection following treatment among people who use drugs.
abstract: Most new cases of hepatitis C virus (HCV) infections in the developed world are associated with injection drug use. However, treatment for people who inject drugs (PWID) is controversial, as successful treatment risks being followed by new infection. Reinfection after sustained virologic response has been reported, but is the risk so great that treatment should be withheld from this large HCV population? Preliminary evidence suggests that the reinfection incidence is low, but studies to date have been limited by small sample size and few cases of reinfection. In this review, we assess data from studies among PWID of HCV reinfection following treatment to give a reasonable estimate on how frequently reinfection appears and try to characterize those most at risk, The observation that spontaneous clearance of HCV reinfection following treatment occurs is suggestive of a partial protective immunity against persistent infection.
authors.affiliation: Department of Infectious Diseases, Center for Infection and Immunity Amsterdam (CINIMA), Amsterdam, the Netherlands.
authors.forename: Bart P
authors.initials: BP
authors.lastname: Grady
authors.forename: Janke
authors.initials: J
authors.lastname: Schinkel
authors.forename: Xiomara V
authors.initials: XV
authors.lastname: Thomas
authors.forename: Olav
authors.initials: O
authors.lastname: Dalgard
mesh_terms: D006526:Hepatitis C / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D012008:Recurrence; D012307:Risk Factors; D015819:Substance Abuse, Intravenous / Q000150:complications*
keywords: clearance; hepatitis C virus; mixed infection; sequence analysis; substance abuse