title: Antioxidant activities of some new chromonyl-2,4-thiazolidinediones and chromonyl-2,4-imidazolidinediones having chromone cores.
abstract: The antioxidant properties of 11 new synthesized chromonyl-2,4-thiazolidinediones and chromonyl-2,4-imidazolidinediones (CBs) were investigated. The antioxidant activities and mechanisms of the CBs interaction with reactive oxygen species (ROS) were clarified using various in vitro antioxidant assay methods including superoxide anion radical (O2(•-)), hydroxyl radical (HO(•)), 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH(•)) scavenging activity and the iron (II)-ferrozine complex formation. The potassium superoxide/18-crown-6 ether dissolved in dimethylsulfoxide (DMSO) was applied as a source of superoxide anion radical. Hydroxyl radicals were produced in the Fenton-like reaction Fe(II)+H2O2. Chemiluminescence, spectrophotometry, and electron paramagnetic resonance (EPR) spectroscopy using 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) as spin trap were applied as the measurement techniques. The CBs examined that exhibited good free radical scavenging activity also showed strong total antioxidant power capacity. Possible mechanisms of antioxidation are proposed to explain the differences in the experimental results between the chromone derivatives with imidazolidine-2,4-dione ring and those with thiazolidine-2,4-dione ring. In conclusion, some of the new CBs are promising to be applied as inhibitors of free radicals.
authors.affiliation: Szczecin Institute of Physics, West Pomeranian University of Technology, al. Piastów 48, 70-311, Szczecin, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Berczyński
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kładna
authors.forename: Irena
authors.initials: I
authors.lastname: Kruk
authors.forename: Teresa
authors.initials: T
authors.lastname: Piechowska
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
authors.forename: Oya
authors.initials: O
authors.lastname: Bozdağ-Dündar
authors.forename: Meltem
authors.initials: M
authors.lastname: Ceylan-Unlusoy
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D002867:Chromones / Q000138:chemical synthesis / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D048289:Imidazolidines / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D017382:Reactive Oxygen Species / Q000737:chemistry; D045162:Thiazolidinediones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D002867:Chromones; D005609:Free Radicals; D048289:Imidazolidines; D017382:Reactive Oxygen Species; D045162:Thiazolidinediones; C000591737:chromonyl-2,4-imidazolidinedione; C000591736:chromonyl-2,4-thiazolidinedione