title: TNFα secretion of monocytes exposed to pulsed radiofrequency treatment: a possible working mechanism of PRF chronic pain management.
abstract: Pulsed radiofrequency treatment (PRF) is a promising new technique increasingly used in treatment of chronic pain. The molecular working mechanism of PRF is not exactly known and is currently being investigated. This study investigates a possible role of PRF-induced modulation of TNFα secretion by differentiated monocytes in chronic pain management. The results show no significant PRF-induced change in TNFα secretion of lipopolysaccharides (LPS)-stimulated monocytes. However, PRF does significantly increase TNFα secretion of differentiated monocytes that have not been stimulated with LPS. This may indicate a possible role of PRF treatment in increasing TNFα production of nonstimulated monocytes. More research is needed to determine whether this is truly a part of the working mechanism of PRF in chronic pain management and which other factors are involved.
authors.affiliation: Fytagoras, Leiden, The Netherlands.
authors.forename: Fabio
authors.initials: F
authors.lastname: Maretto
authors.forename: Marco
authors.initials: M
authors.lastname: Vennik
authors.forename: Kim I
authors.initials: KI
authors.lastname: Albers
authors.forename: Bert
authors.initials: B
authors.lastname: van Duijn
mesh_terms: D059350:Chronic Pain / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D059408:Pain Management / Q000379:methods*; D061208:Pulsed Radiofrequency Treatment / Q000379:methods*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D020298:U937 Cells
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: PRF; Pain; TNFα; immunological factors; molecular mechanisms of action; monocytes; pulsed radiofrequency