title: [Glial cells and chronic pain: from the laboratory to clinical hope].
abstract: Despite their high prevalence, associated disability and seemingly rich pharmacopeia, the various forms of chronic pain remain frequently intractable. The past decade witnessed the rise of a concept stating that non-neuronal cells of the central nervous system, astrocytes and microglia, are crucial elements in pathological pain. This review gathers and summarizes the experimental data underpinning this theory in animal models and addresses their pertinence in humans. The potential opportunities and constraints of glial inhibition are exposed and compared to more moderate strategies of selective modulation. This therapeutic hope is particularly highlighted in our discussion of the first completed clinical trials employing glial inhibitors in the treatment of chronic pain.
authors.affiliation: Centre d'antalgie, Service d'anesthésiologie, CHUV, 1011 Lausanne. christine.clarke@unil.ch
authors.forename: Christine B
authors.initials: CB
authors.lastname: Clarke
authors.forename: Marc R
authors.initials: MR
authors.lastname: Suter
authors.forename: Romain Daniel
authors.initials: RD
authors.lastname: Gosselin
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000818:Animals; D001253:Astrocytes; D002490:Central Nervous System / Q000503:physiopathology; D059350:Chronic Pain / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D002986:Clinical Trials as Topic; D019317:Evidence-Based Medicine; D006801:Humans; D017628:Microglia; D009457:Neuroglia / Q000187:drug effects; D010148:Intractable Pain / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic