title: [Expression and survival prediction of microRNA-155 in hepatocellular carcinoma after liver transplantation].
abstract: OBJECTIVE
  To explore the expression of microRNA-155 in hepatocellular carcinoma (HCC) and its contribution to recurrence and prognosis of HCC after liver transplantation (LT).
  
  
  METHODS
  The expression levels of microRNA-155 in 100 HCC samples were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Kaplan-Meier and Cox proportional regression analyses were utilized to determine the association of microRNA-155 expression with patient survivals.
  
  
  RESULTS
  The expression levels of microRNA-155 were higher in primary HCC patients with post-LT recurrence (n = 45, mean relative level = 14.94) than those with non-recurrence (n = 55, mean relative level = 4.70) (P = 0.001) and correlated with micro-vascular invasion of HCC tissue samples (P = 0.001). The patients with a higher expression of microRNA-155 had significantly worse recurrence-free survival (RFS: (21.5 ± 3.2) months, log rank P < 0.001) and overall survival (OS: (29.3 ± 3.2) months, log rank P < 0.001) than those with a lower expression of microRNA-155 (RFS: (50.8 ± 3.2) months; OS: (54.6 ± 3.5) months). Multivariate analysis revealed that a high expression of miR-155 was an independent prognostic predictor.
  
  
  CONCLUSIONS
  MicroRNA-155 is over-expressed in primary HCC with tumor recurrence and may serve as a novel biomarker for tumor recurrence and survival of HCC patients after LT. The detection of microRNA-155 is of clinical significance in HCC.
authors.affiliation: Department of General Surgery, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Zhong-bo
authors.initials: ZB
authors.lastname: Han
authors.forename: Hong-yuan
authors.initials: HY
authors.lastname: Chen
authors.forename: Jun-wei
authors.initials: JW
authors.lastname: Fan
authors.forename: Jun-yi
authors.initials: JY
authors.lastname: Wu
authors.forename: Zhi-hai
authors.initials: ZH
authors.lastname: Peng
authors.forename: Zhao-wen
authors.initials: ZW
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C524942:MIRN155 microRNA, human; D035683:MicroRNAs