title: Rational design of multifunctional upconversion nanocrystals/polymer nanocomposites for cisplatin (IV) delivery and biomedical imaging.
abstract: By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
authors.forename: Ping'an
authors.initials: P
authors.lastname: Ma
authors.forename: Haihua
authors.initials: H
authors.lastname: Xiao
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Li
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.forename: Yunlu
authors.initials: Y
authors.lastname: Dai
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002460:Cell Line; D002945:Cisplatin / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000032:analysis*; D006801:Humans; D051379:Mice; D053761:Nanocomposites / Q000032:analysis* / Q000648:ultrastructure; D053758:Nanoparticles / Q000032:analysis / Q000648:ultrastructure; D061848:Optical Imaging / Q000379:methods*; D011108:Polymers / Q000032:analysis*
chemical_list: D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D011108:Polymers; D002945:Cisplatin
keywords: biomedical imaging; cisplatin; drug delivery; self-assembly; upconversion fluorescent