title: Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.
abstract: The effects and mechanisms of the total flavonoids (TFs) from Rosa laevigata Michx fruit on high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) were investigated in this study. Gavage administration of the TFs significantly decreased the relative liver weight, serum AST and ALT activities, the levels of serum lipid, LDL, blood glucose and insulin, suppressed lipid accumulation in liver, and increased serum HDL level. Moreover, the natural product significantly enhanced SOD activity, increased GSH-Px and GSH contents and decreased the concentration of MDA and CYP2E1 expression as well as prevented mitochondrial membrane potential dysfunctions and ultrastructural alterations. Further mechanism investigation indicated that the TFs inhibited hepatic lipid accumulation by suppressing the expressions of some key molecules in fatty acid synthesis pathway and promoting fatty acid β-oxidation, while not by inhibiting cholesterol synthesis. On the base of these, the TFs should be developed as a new drug for treatment of NAFLD.
authors.affiliation: College of Pharmacy, Dalian Medical University, 9 Western Lvshun South Road, Dalian 116044, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.forename: Lingli
authors.initials: L
authors.lastname: Zheng
authors.forename: Deshi
authors.initials: D
authors.lastname: Dong
authors.forename: Lina
authors.initials: L
authors.lastname: Xu
authors.forename: Lianhong
authors.initials: L
authors.lastname: Yin
authors.forename: Yan
authors.initials: Y
authors.lastname: Qi
authors.forename: Xu
authors.initials: X
authors.lastname: Han
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lin
authors.forename: Kexin
authors.initials: K
authors.lastname: Liu
authors.forename: Jinyong
authors.initials: J
authors.lastname: Peng
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D005234:Fatty Liver / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D005419:Flavonoids / Q000008:administration & dosage*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D027826:Rosa / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Fatty acid synthesis; Fatty acid β-oxidation; Non-alcoholic fatty liver disease; Rosa laevigata Michx; Total flavonoids