title: [Application of genipin for modification of natural biomaterials as a crosslinking agent].
abstract: OBJECTIVE
  To review the application of genipin for the modification of natural biomaterials as a crosslinking agent and progress in research.
  
  
  METHODS
  Domestic and foreign literature on application of genipin for the modification of natural biomaterials as a crosslinking agent was thoroughly reviewed. Results Genipin is an effective natural crosslinking agent with a very low level of cytotoxicity compared with conventional synthetic crosslinking agents. Tissues fixed with genipin can maintain a high level of stability as well as resistance to enzymatic degradation.
  
  
  CONCLUSIONS
  Genipin is a promising substitute for conventional synthetic crosslinking agents, which has offered an alternative for modification of natural biomaterials for tissue engineering.
authors.affiliation: Laboratory of Stem Cell and Tissue Engineering, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Lincui
authors.initials: L
authors.lastname: Da
authors.forename: Yan
authors.initials: Y
authors.lastname: Xie
authors.forename: Huiqi
authors.initials: H
authors.lastname: Xie
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D023822:Tissue Engineering / Q000379:methods*; D016707:Tissue Fixation / Q000379:methods; D054457:Tissue Scaffolds; D018675:Toxicity Tests
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D039823:Iridoids; C007834:genipin