title: Route of sexual exposure is independently associated with seropositivity to HPV-16 and HPV-18 among clients of an STI clinic in the Netherlands.
abstract: We investigated the route of sexual exposure as a determinant for human papillomavirus (HPV)-16 and HPV-18 seropositivity. At the Amsterdam sexually transmitted infections clinic we recruited 4 risk groups: (1) men who have sex with women only (MSW; n = 751); (2) women who have sex with men (WSM; n = 749); (3) men who have sex with men (MSM) reporting insertive anal sex only (insMSM; n = 156); and (4) MSM reporting receptive anal sex (recMSM; n = 415). In multivariable analyses, HPV-16 seropositivity was significantly more common in WSM vs MSW, recMSM vs MSW, and recMSM vs insMSM. HPV-18 results were similar. Route of sexual exposure is independently associated with HPV seropositivity.
authors.affiliation: Department of Infectious Diseases, Public Health Service of Amsterdam, The Netherlands.
authors.forename: Marlies
authors.initials: M
authors.lastname: Heiligenberg
authors.forename: Catharina J
authors.initials: CJ
authors.lastname: Alberts
authors.forename: Tim
authors.initials: T
authors.lastname: Waterboer
authors.forename: Arjen G C L
authors.initials: AG
authors.lastname: Speksnijder
authors.forename: Henry J C
authors.initials: HJ
authors.lastname: De Vries
authors.forename: Michael
authors.initials: M
authors.lastname: Pawlita
authors.forename: Maarten F
authors.initials: MF
authors.lastname: Schim van der Loeff
mesh_terms: D000328:Adult; D005260:Female; D052162:Human papillomavirus 16 / Q000276:immunology*; D052161:Human papillomavirus 18 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D016036:Seroepidemiologic Studies; D012725:Sexual Behavior; D015229:Sexually Transmitted Diseases, Viral / Q000453:epidemiology* / Q000821:virology*; D055815:Young Adult
keywords: HPV; HPV antibodies; STI; men who have sex with men (MSM); route of sexual exposure; seroprevalence; the Netherlands