title: Management of Medication-Related Cardiometabolic Risk in Patients with Severe Mental Illness.
abstract: Severe psychotic disorders, which on their own may be a risk factor for metabolic disorder and cardiovascular illness, are clinically compounded by the significant adverse side effects of antipsychotic medications. The majority of patients with severe psychotic disorders (i.e., schizophrenia, bipolar disorder, mania, and depression) must take antipsychotic medications to treat their psychoses and, subsequently, will require efficacious interventions to manage the metabolic consequences of pharmacologic treatment to mitigate excessive mortality associated with cardiovascular illness. We have reviewed the metabolic consequences of antipsychotic treatment and discussed pilot findings from a new nonpharmacologic intervention study looking at the clinical benefits of regular exercise as a management tool for the cardiometabolic risk factors in a cohort with severe mental illness.
authors.affiliation: Department of Radiology, University of British Columbia, Centre for Complex Disorders, British Columbia Mental Health and Addictions Research Institute, CFRI Bldg, Rm. 3A-124, 938 West 28th Ave, BC Children's Hospital Site, Vancouver, BC Canada V5Z 4H4.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Lang
authors.forename: Alasdair M
authors.initials: AM
authors.lastname: Barr
authors.forename: Ric M
authors.initials: RM
authors.lastname: Procyshyn
keywords: Antipsychotics; Cardiometabolic disorder; Exercise; Mental illness