title: Lateral and dorsal column hyperintensity on magnetic resonance imaging in a patient with myelopathy associated with intrathecal chemotherapy.
abstract: Chemotherapy-related myelopathy mimicking subacute combined degeneration (SCD) has rarely been reported. We encountered a 35-year-old female with sensory ataxia after intrathecal chemotherapy. Spinal magnetic resonance imaging showed localized abnormal signal areas in the lateral and dorsal white matter, mimicking SCD. Diffusion imaging showed restricted water diffusion and increased microstructural complexity, and cerebrospinal fluid analysis showed increased levels of myelin basic proteins, indicating demyelinating myelopathy. Advanced diffusion imaging can provide more information on the microstructure of chemotherapy-related myelopathy.
authors.affiliation: Department of Neurology, Department of Internal Medicine, Tokyo, Japan ; Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Fumine
authors.initials: F
authors.lastname: Saito
authors.forename: Taku
authors.initials: T
authors.lastname: Hatano
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hori
authors.forename: Miwako
authors.initials: M
authors.lastname: Kawamura
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
keywords: Cytosine arabinoside; Diffusion imaging; Magnetic resonance imaging; Methotrexate; Spinal cord; Subacute combined degeneration