title: A ratiometric near-infrared fluorescent probe for hydrazine and its in vivo applications.
abstract: Based on modulation of the conjugated polymethine π-electron system of a cyanine dye derivative, a ratiometric near-infared fluorescent probe (Cy7A) for hydrazine (N2H4) has been designed and synthesized. Cy7A can be selectively hydrazinolysized with great changes in its fluorescent excitation/emission profiles, which makes it possible to detect N2H4 in water samples and living cells and, for the first time, visualize N2H4 in living mice.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, PR China.
authors.forename: Chong
authors.initials: C
authors.lastname: Hu
authors.forename: Wen
authors.initials: W
authors.lastname: Sun
authors.forename: Jianfang
authors.initials: J
authors.lastname: Cao
authors.forename: Pan
authors.initials: P
authors.lastname: Gao
authors.forename: Jingyun
authors.initials: J
authors.lastname: Wang
authors.forename: Jiangli
authors.initials: J
authors.lastname: Fan
authors.forename: Fengling
authors.initials: F
authors.lastname: Song
authors.forename: Shiguo
authors.initials: S
authors.lastname: Sun
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Peng
mesh_terms: D000818:Animals; D002232:Carbocyanines / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D019265:Spectroscopy, Near-Infrared
chemical_list: D002232:Carbocyanines; D005456:Fluorescent Dyes; D006834:Hydrazines