title: Enantiomeric separation of 13 new amphetamine-like designer drugs by capillary electrophoresis, using modified-B-cyclodextrins.
abstract: An easy-to-prepare chiral CE method for the enantiomeric separation of 13 new amphetamine-like designer drugs, using CDs as chiral selectors, was developed. Sulfated-β-CD was found to be the best chiral selector among the three used (sulfated-β-CD, caroboxymethyl-β-CD, dimethyl-β-CD). The separation of the analytes was achieved in a fused-silica gel capillary at 20 °C using an applied voltage of +25 kV. The optimized background electrolyte consisted of 63.5 mM H3 PO4 and 46.9 mM NaOH in water. Several electrophoretic parameters such as CD type, CD concentration (1 - 40 mg/mL), buffer pH (2.6, 3.6, 5.0, 6.0), length of the capillary (70 - 40 cm total length), amount of the organic solvent (methanol and acetonitrile) were investigated and optimized.
authors.affiliation: Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Sassari, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Burrai
authors.forename: Maria
authors.initials: M
authors.lastname: Nieddu
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Pirisi
authors.forename: Antonio
authors.initials: A
authors.lastname: Carta
authors.forename: Irene
authors.initials: I
authors.lastname: Briguglio
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Boatto
mesh_terms: D000661:Amphetamine / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D015198:Designer Drugs / Q000032:analysis / Q000737:chemistry* / Q000145:classification; D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D015203:Reproducibility of Results; D013237:Stereoisomerism; D013997:Time Factors
chemical_list: D003505:Cyclodextrins; D015198:Designer Drugs; D000661:Amphetamine
keywords: CM-β-cyclodextrin; DM-β-cyclodextrin; S-β-cyclodextrin; chiral separation; dimethoxy-amphetamines; paramethoxy-amphetamines; trimethoxy-amphetamines