title: Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy.
abstract: A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.
authors.affiliation: The Brain Tumor Center, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cheng
authors.forename: Ramin
authors.initials: R
authors.lastname: Morshed
authors.forename: Shih-Hsun
authors.initials: SH
authors.lastname: Cheng
authors.forename: Alex
authors.initials: A
authors.lastname: Tobias
authors.forename: Brenda
authors.initials: B
authors.lastname: Auffinger
authors.forename: Derek A
authors.initials: DA
authors.lastname: Wainwright
authors.forename: Lingjiao
authors.initials: L
authors.lastname: Zhang
authors.forename: Catherine
authors.initials: C
authors.lastname: Yunis
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.forename: Chin-Tu
authors.initials: CT
authors.lastname: Chen
authors.forename: Leu-Wei
authors.initials: LW
authors.lastname: Lo
authors.forename: Karen S
authors.initials: KS
authors.lastname: Aboody
authors.forename: Atique U
authors.initials: AU
authors.lastname: Ahmed
authors.forename: Maciej S
authors.initials: MS
authors.lastname: Lesniak
mesh_terms: D000818:Animals; D017209:Apoptosis; D001932:Brain Neoplasms / Q000628:therapy*; D016923:Cell Death; D045744:Cell Line, Tumor; D002465:Cell Movement; D002986:Clinical Trials as Topic; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005909:Glioblastoma / Q000628:therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes; D051379:Mice; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry*; D009368:Neoplasm Transplantation; D058953:Neural Stem Cells / Q000166:cytology* / Q000648:ultrastructure
chemical_list: D004317:Doxorubicin
keywords: doxorubicin; drug delivery; glioblastoma; glioma; mesoporous silica nanoparticles; neural stem cells; targeted delivery