title: Macrolide resistance of Mycoplasma pneumoniae, South Korea, 2000-2011.
abstract: In Korea, Mycoplasma pneumoniae was detected in 255/2,089 respiratory specimens collected during 2000-2011; 80 isolates carried 23S rRNA gene mutations, and 69/123 culture-positive samples with the mutation were resistant to 5 macrolides. During 2000-2011, prevalence of the mutation increased substantially. These findings have critical implications for the treatment of children with mycoplasma pneumonia.
authors.affiliation: Seoul National University Hospital, Seoul, South Korea.
authors.forename: Ki Bae
authors.initials: KB
authors.lastname: Hong
authors.forename: Eun Hwa
authors.initials: EH
authors.lastname: Choi
authors.forename: Hoan Jong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Seong Yeon
authors.initials: SY
authors.lastname: Lee
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Cho
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Choi
authors.forename: Hyun Mi
authors.initials: HM
authors.lastname: Kang
authors.forename: Jina
authors.initials: J
authors.lastname: Lee
authors.forename: Young Min
authors.initials: YM
authors.lastname: Ahn
authors.forename: Yeon-Ho
authors.initials: YH
authors.lastname: Kang
authors.forename: Joon-Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D058872:Epidemics; D024841:Fluoroquinolones / Q000494:pharmacology; D006801:Humans; D007223:Infant; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000235:genetics; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D015995:Prevalence; D012329:RNA, Bacterial / Q000235:genetics; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D056910:Republic of Korea / Q000453:epidemiology; D013754:Tetracyclines / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D018942:Macrolides; D012329:RNA, Bacterial; D012338:RNA, Ribosomal, 23S; D013754:Tetracyclines
keywords: Mycoplasma pneumoniae; South Korea; macrolide; pneumonia; resistance; respiratory infections; tuberculosis and other mycobacteria