title: Distribution of genital wart human papillomavirus genotypes in China: a multi-center study.
abstract: Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with genital warts, there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in genital warts across China, and thus to evaluate the potential benefit of a quadrivalent HPV vaccine in this population. The tissue samples of a total of 1,005 genital warts cases were collected from seven geographical regions of China. HPV genotypes were analyzed using the general primer PCR and sequence-based typing method. Prevalence differences between sexes, geographical regions and age groups were assessed. The overall prevalence of HPV DNA in genital warts patients was 88.7% (891/1,005). Low-risk genotypes predominated, with a prevalence of 78.1% (785/1,005). The most prevalent genotypes were HPV-6 (41.3%), HPV-11 (37.6%) and HPV-16 (10.4%). Among HPV positive patients, single infections were more frequent (866/891, 97.2%) than co-infections (25/891, 2.8%). Both the overall prevalence of HPV DNA and that of HPV-6/-11/-16 (positive for any of the three types) decreased with age (P-trend = 0.010 and P-trend = 0.025, respectively). The prevalence of HPV-6/-11 (positive for either HPV type) and HPV-16 varied by geographic region (P = 0.003 and P ≤ 0.001, respectively). The prevalence of HPV-16 in female patients between urban and rural areas showed a marginally significant difference (P = 0.05). In sum, the results provide strong evidence that, in China, the most prevalent HPV genotypes in genital warts are HPV-6, HPV-11 and HPV-16. This indicates that a quadrivalent HPV vaccine may decrease the incidence of genital warts in the future.
authors.affiliation: State Key Laboratory of Biocontrol, Department of Biochemistry, School of Life Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Chang
authors.forename: Puwa
authors.initials: P
authors.lastname: Ci
authors.forename: Jufang
authors.initials: J
authors.lastname: Shi
authors.forename: Kan
authors.initials: K
authors.lastname: Zhai
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Feng
authors.forename: Danny
authors.initials: D
authors.lastname: Colombara
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Youlin
authors.initials: Y
authors.lastname: Qiao
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Yuping
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D003218:Condylomata Acuminata / Q000453:epidemiology / Q000821:virology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D058889:Molecular Typing; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D015995:Prevalence; D017422:Sequence Analysis, DNA; D055815:Young Adult
keywords: China; HPV genotypes; distribution; genital warts; human papillomavirus