title: The incidence of acute pancreatitis: impact of social deprivation, alcohol consumption, seasonal and demographic factors.
abstract: BACKGROUND
  The incidence of acute pancreatitis has increased sharply in many European countries and the USA in recent years.
  
  
  OBJECTIVE
  To establish trends in incidence and mortality for acute pancreatitis in Wales, UK, and to assess how incidence may be linked to factors including social deprivation, seasonal effects and alcohol consumption.
  
  
  METHODS
  Use of record linked inpatient, mortality and primary care data for 10,589 hospitalised cases of acute pancreatitis between 1999 and 2010.
  
  
  RESULTS
  The incidence of acute pancreatitis was 30.0 per 100,000 population overall, mortality was 6.4% at 60 days. Incidence increased significantly from 27.6 per 100,000 in 1999 to 36.4 in 2010 (average annual increase = 2.7% per year), there was little trend in mortality (0.2% average annual reduction). The largest increases in incidence were among women aged <35 years (7.9% per year) and men aged 35-44 (5.7%) and 45-54 (5.3%). Incidence was 1.9 times higher among the most deprived quintile of patients compared with the most affluent (3.9 times higher for alcoholic acute pancreatitis and 1.5 for gallstone acute pancreatitis). Acute pancreatitis was increased significantly during the Christmas and New Year weeks by 48% (95% CI = 24-77%) for alcoholic aetiology, but not for gallstone aetiology (9%). Alcoholic admissions were increased with higher consumption of spirits and beer, but not wine.
  
  
  CONCLUSIONS
  The study shows an elevated rate of alcoholic acute pancreatitis during the Christmas and New Year period. Acute pancreatitis continues to rise, most rapidly for young women, while alcoholic acute pancreatitis is linked strongly with social deprivation.
authors.affiliation: College of Medicine, Swansea University, Swansea, UK. stephen.e.roberts@swansea.ac.uk
authors.forename: S E
authors.initials: SE
authors.lastname: Roberts
authors.forename: A
authors.initials: A
authors.lastname: Akbari
authors.forename: K
authors.initials: K
authors.lastname: Thorne
authors.forename: M
authors.initials: M
authors.lastname: Atkinson
authors.forename: P A
authors.initials: PA
authors.lastname: Evans
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000401:mortality; D003710:Demography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019512:Pancreatitis, Alcoholic / Q000453:epidemiology* / Q000401:mortality; D011610:Psychosocial Deprivation; D012307:Risk Factors; D012621:Seasons; D012959:Socioeconomic Factors; D014852:Wales / Q000453:epidemiology; D055815:Young Adult