title: Castor oil, bath and/or enema for cervical priming and induction of labour.
abstract: BACKGROUND
  Castor oil, a potent cathartic, is derived from the bean of the castor plant. Anecdotal reports, which date back to ancient Egypt have suggested the use of castor oil to stimulate labour. Castor oil has been widely used as a traditional method of initiating labour in midwifery practice. Its role in the initiation of labour is poorly understood and data examining its efficacy within a clinical trial are limited. This is one of a series of reviews of methods of cervical ripening and labour induction using standardised methodology.
  
  
  OBJECTIVE
  To determine the effects of castor oil or enemas for third trimester cervical ripening or induction of labour in comparison with other methods of cervical ripening or induction of labour.
  
  
  METHODS
  We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 April 2013) and bibliographies of relevant papers.
  
  
  METHODS
  Clinical trials comparing castor oil, bath or enemas used for third trimester cervical ripening or labour induction with placebo/no treatment or other methods listed above it on a predefined list of labour induction methods.
  
  
  METHODS
  A strategy was developed to deal with the large volume and complexity of trial data relating to labour induction. This involved a two-stage method of data extraction.
  
  
  RESULTS
  Three trials, involving 233 women, are included. There was no evidence of differences in caesarean section rates between the two interventions in the two trials reporting this outcome (risk ratio (RR) 2.04, 95% confidence interval (CI) 0.92 to 4.55). There were no data presented on neonatal or maternal mortality or morbidity.There was no evidence of a difference between castor oil and placebo/no treatment for the rate of instrumental delivery, meconium-stained liquor, or Apgar score less than seven at five minutes. The number of participants was too small to detect all but large differences in outcome. All women who ingested castor oil felt nauseous (RR 59.92, 95% CI 8.46 to 424.52).
  
  
  CONCLUSIONS
  The three trials included in the review contain small numbers of women. All three studies used single doses of castor oil. The results from these studies should be interpreted with caution due to the risk of bias introduced due to poor methodological quality. Further research is needed to attempt to quantify the efficacy of castor oil as an cervical priming and induction agent.
authors.affiliation: Department of Obstetrics and Gynaecology, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.tony.kelly@bsuh.nhs.uk.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Kelly
authors.forename: Josephine
authors.initials: J
authors.lastname: Kavanagh
authors.forename: Jane
authors.initials: J
authors.lastname: Thomas
mesh_terms: D002368:Castor Oil / Q000008:administration & dosage / Q000009:adverse effects; D020070:Cervical Ripening; D002585:Cesarean Section / Q000706:statistics & numerical data; D004733:Enema; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011453:Prostaglandins; D016032:Randomized Controlled Trials as Topic
chemical_list: D010120:Oxytocics; D011453:Prostaglandins; D002368:Castor Oil