title: Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus Aspergillus nidulans.
abstract: Four new quinazolinone alkaloids, namely, aniquinazolines A-D (1-4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China. anchy5885@gmail.com
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: An
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Li
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Wang
authors.forename: Gang-Ming
authors.initials: GM
authors.lastname: Xu
authors.forename: Bin-Gui
authors.initials: BG
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D001233:Aspergillus nidulans / Q000737:chemistry*; D001685:Biological Factors / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray / Q000379:methods; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D052999:Quinazolinones / Q000737:chemistry* / Q000494:pharmacology*; D043982:Rhizophoraceae / Q000382:microbiology; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001685:Biological Factors; D052999:Quinazolinones