title: A case of acute promyelocytic leukemia with morphologic multilineage dysplastic changes.
abstract: Although reports of typical acute promyelocytic leukemia (APL) cases rarely mention dysplastic changes, this report concerns a rare case of APL with tri-lineage dysplastic changes resembling the characteristic features of myelodysplastic syndrome (MDS). The patient, a 77-year-old Japanese male, was diagnosed as having pancytopenia with hematologic morphological abnormalities comprising micro - megakaryocytes, neutrophils with hypo-granulation and negative peroxidase activity, and erythroblasts containing nuclei with abnormalities such as karyorrhexis. Although there is one report of a case of transformation of de novo MDS into APL and several reports of cases of therapy-related MDS transformed into APL, our patient had no history of cytopenia or of either chemo or radiation therapy. Our case can thus be considered to constitute a rare case of APL with dysplastic morphology.
authors.affiliation: Clinical Laboratory, Kakogawa West City Hospital.
authors.forename: Setsuki
authors.initials: S
authors.lastname: Isono
authors.forename: Katsuyasu
authors.initials: K
authors.lastname: Saigo
authors.forename: Keiko
authors.initials: K
authors.lastname: Nagata
authors.forename: Keiko
authors.initials: K
authors.lastname: Numata
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kojitani
authors.forename: Akiharu
authors.initials: A
authors.lastname: Okamura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nishizawa
authors.forename: Masafumi
authors.initials: M
authors.lastname: Takata
authors.forename: Mariko
authors.initials: M
authors.lastname: Takenokuchi
authors.forename: Eiji
authors.initials: E
authors.lastname: Tatsumi
keywords: acute promyelocytic leukemia; all-trans retinoic acid; dysplasia