title: Identification of extended-spectrum-β-lactamase-positive Klebsiella pneumoniae urinary tract isolates harboring KPC and CTX-M β-lactamases in nonhospitalized patients.
abstract: Forty-seven extended-spectrum-β-lactamase-positive Klebsiella pneumoniae urinary tract isolates from nonhospitalized patients were identified, and 79% harbored KPC and/or CTX-M β-lactamases. Approximately 90% of the isolates were resistant to trimethoprim-sulfamethoxazole and levofloxacin, and 40% were resistant to a carbapenem, while 92% were susceptible to polymyxin B, 87% were susceptible to tigecycline, and 79% were susceptible to fosfomycin. Increased use of broader-spectrum antibiotics may help to prevent their dissemination and reduce the risk of progression to invasive disease.
authors.affiliation: The Dr. James J. Rahal Division of Infectious Diseases, New York Hospital Queens, Flushing, New York.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kopacz
authors.forename: Noriel
authors.initials: N
authors.lastname: Mariano
authors.forename: Rita
authors.initials: R
authors.lastname: Colon-Urban
authors.forename: Paul
authors.initials: P
authors.lastname: Sychangco
authors.forename: Wehbeh
authors.initials: W
authors.lastname: Wehbeh
authors.forename: Sorana
authors.initials: S
authors.lastname: Segal-Maurer
authors.forename: Carl
authors.initials: C
authors.lastname: Urban
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D005578:Fosfomycin / Q000494:pharmacology; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology*; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D000078304:Tigecycline; D014551:Urinary Tract / Q000382:microbiology*; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D005578:Fosfomycin; D000078304:Tigecycline; D001618:beta-Lactamases; D008911:Minocycline