title: Parapharengeal unicentric Castleman disease with nephrotic syndrome.
abstract: Castleman disease (CD) is a rare lymphoproliferative disorder, first described in 1956. This case report describes a 27-year-old man with hyaline vascular unicentric CD, first presented with edema and hypertension. On initial evaluation for edema, 24-hour urine collection revealed 8200 mg/24 h protein excretion. Pathologic examination of the kidney specimen showed diffuse mesangial lesions with segmental subepithelial deposition. On follow-up for nephrotic syndrome, the patient experienced a feeling of a mass in his pharynx and deterioration of previous snoring, documented by neck magnetic resonance imaging. Pathology report of the excisional biopsy showed CD. Treatment with corticosteroids and partial excision can be considered as an alternative to surgery for unresectable unicentric CD. The 5-year follow-up showed that this strategy could lead to remission.
authors.affiliation: Department of Nephrology, School of Medicine, Qom University of Medical Sciences, Qom, Iran. dr.hosseinsaghafi@gmail.com
authors.forename: Hossein
authors.initials: H
authors.lastname: Saghafi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aghaali
authors.forename: Samaneh
authors.initials: S
authors.lastname: Haghighi
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004487:Edema / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D010608:Pharyngeal Diseases / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D011239:Prednisolone / Q000627:therapeutic use; D012074:Remission Induction; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D011239:Prednisolone