title: Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors.
abstract: Injection of effector proteins by a type III secretion system (T3SS) is a common infection strategy employed by many important human pathogens, including enteric Escherichia coli, Salmonella, Yersinia, and Shigella, to subvert cell signaling and host responses. In recent years, great advances have been made in understanding how the T3SS effectors function and execute the diverse infection strategies employed by these pathogens. In this review, we focus on effectors that subvert signaling pathways that impact on endosomal trafficking, cell survival, and innate immunity, particularly phagocytosis, nuclear factor-κB (NF-κB), and mitogen-activated protein (MAP) kinase pathways and the inflammasome.
authors.affiliation: Department of Life Sciences, Imperial College, London, UK.
authors.forename: Benoit
authors.initials: B
authors.lastname: Raymond
authors.forename: Joanna C
authors.initials: JC
authors.lastname: Young
authors.forename: Mitchell
authors.initials: M
authors.lastname: Pallett
authors.forename: Robert G
authors.initials: RG
authors.lastname: Endres
authors.forename: Abigail
authors.initials: A
authors.lastname: Clements
authors.forename: Gad
authors.initials: G
authors.lastname: Frankel
mesh_terms: D000818:Animals; D017209:Apoptosis; D011992:Endosomes / Q000378:metabolism*; D004755:Enterobacteriaceae / Q000276:immunology / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000378:metabolism; D020935:MAP Kinase Signaling System; D026901:Membrane Transport Proteins / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D010587:Phagocytosis; D021381:Protein Transport; D015398:Signal Transduction; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D058847:Inflammasomes; D026901:Membrane Transport Proteins; D016328:NF-kappa B; D037521:Virulence Factors
keywords: T3SS; cell survival modulation; enteropathogens; inflammatory response manipulation; phagocytosis remodeling; subversion of cellular trafficking