title: Evaluation of the protective effects of CoQ₁₀ on ovarian I/R injury: an experimental study.
abstract: BACKGROUND
  The aim of this study was to investigate the protective effects of coenzyme Q₁₀ (CoQ₁₀) on ovarian ischemia/reperfusion injury in an experimental rat adnexal torsion model.
  
  
  METHODS
  48 female adult Wistar albino rats, weighing 220-250 g, were randomly equally divided into six groups (n = 8): sham, torsion, detorsion, sham+CoQ₁₀, torsion+CoQ₁₀, and detorsion+CoQ₁₀ groups. Bilateral adnexal torsion was performed for 3 h in all groups, except the sham and sham+CoQ₁₀ groups. Bilateral adnexal detorsion was performed on the detorsion and detorsion+CoQ₁₀ groups. CoQ₁₀ was injected intraperitoneally 30 min before the sham operation, torsion, and detorsion.
  
  
  RESULTS
  The torsion and detorsion groups had significantly higher histologic evaluation scores, as well as higher MDA levels, TOS values, and oxidative stress index values than the sham group. A strong correlation between total histologic evaluation scores for ischemia/reperfusion injury and the oxidative stress index was found. The mean oxidant marker levels and histopathologic scores for the ovarian tissue significantly decreased after using CoQ₁₀, which is a potent antioxidant.
  
  
  CONCLUSIONS
  Conservative surgery (detorsion) was found to provide inadequate protection to ovarian tissue. The results of this study suggest that CoQ₁₀ could be useful for the protection of ovarian tissue before conservative surgery.
authors.affiliation: Department of Obstetrics and Gynecology, Dicle University, Diyarbakır, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ozler
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Turgut
authors.forename: Neval Yaman
authors.initials: NY
authors.lastname: Görük
authors.forename: Ulas
authors.initials: U
authors.lastname: Alabalik
authors.forename: Mustafa Kemal
authors.initials: MK
authors.lastname: Basarali
authors.forename: Fatih
authors.initials: F
authors.lastname: Akdemir
mesh_terms: D000818:Animals; D043303:Aryldialkylphosphatase / Q000378:metabolism; D005260:Female; D008315:Malondialdehyde / Q000378:metabolism; D010053:Ovary / Q000098:blood supply*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D014102:Torsion Abnormality / Q000150:complications / Q000601:surgery*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D014451:Ubiquinone; D008315:Malondialdehyde; C572204:Pon1 protein, rat; D043303:Aryldialkylphosphatase; C024989:coenzyme Q10