title: Co-polysomy of chromosome 1q and 19p predicts worse prognosis in 1p/19q codeleted oligodendroglial tumors: FISH analysis of 148 consecutive cases.
abstract: BACKGROUND
  This study aimed to evaluate the prognostic significance of co-polsomy of chromosome 1q and 19p in 1p/19q codeleted oligodendroglial tumors (ODGs).
  
  
  METHODS
  In a series of 148 ODGs with 1p/19q deletion, co-polysomy of 1q and 19p was detected by fluorescence in situ hybridization (FISH). Log-rank analysis and Cox regression methods were used to compare Kaplan-Meier plots and identify factors associated with worse prognosis.
  
  
  RESULTS
  There were 104 (70.3%) low-grade ODGs and 44 (29.7%) high-grade ODGs. Co-polysomy was independently associated with shorter progression-free survival and overall survival in 1p/19q codeleted ODGs, irrespective of tumor grades. The odds ratio of without and with co-polysomy was 0.263 (95% confidence interval [CI], 0.089-0.771; P = .015) for progression-free survival and 0.213 (95% CI, 0.060-0.756; P = .017) for overall survival. Subgroup analysis confirmed this trend in both low-grade and high-grade ODGs, although the P value for high-grade ODGs was marginally significant.
  
  
  CONCLUSIONS
  Co-polysomy of 1q and 19p could be used as a marker to independently predict worse prognoses and guide individual therapy in 1p/19q codeleted ODGs.
authors.affiliation: Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Ren
authors.forename: Haihui
authors.initials: H
authors.lastname: Jiang
authors.forename: Xiangli
authors.initials: X
authors.lastname: Cui
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Zhongli
authors.initials: Z
authors.lastname: Jiang
authors.forename: Dali
authors.initials: D
authors.lastname: Sui
authors.forename: Song
authors.initials: S
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000175:diagnosis* / Q000235:genetics*; D011379:Prognosis; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: 1p/19q co-deletion; co-polysomy; oligodendroglial tumors; prognosis; survival