title: The antidepressant-like effect of bacopaside I: possible involvement of the oxidative stress system and the noradrenergic system.
abstract: In the present study, the antidepressant-like effect of bacopaside I, a saponin compound present in the Bacopa monniera plant, was evaluated by behavioral and neurochemical methods. Bacopaside I (50, 15 and 5 mg/kg) was given to mice via oral gavage for 7 successive days. The treatment significantly decreased the immobility time in mouse models of despair tests, but it did not influence locomotor activity. Neurochemical assays suggested that treatment by bacopaside I (50, 15 and 5 mg/kg) improved brain antioxidant activity to varying degrees after the behavioral despair test. Bacopaside I (15 and 5 mg/kg) significantly reversed reserpine-induced depressive-like behaviors, including low temperature and ptosis. Conversely, bacopaside I did not affect either brain MAO-A or MAO-B activity after the behavioral despair test in mice. Additionally, 5-hydroxytryptophan (a precursor of 5-serotonin) was not involved in the antidepressant-like effect of bacopaside I. These findings indicated that the antidepressant-like effect of bacopaside I might be related to both antioxidant activation and noradrenergic activation, although the exact mechanism remains to be further elucidated.
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Rongcai
authors.initials: R
authors.lastname: Yue
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.forename: Jigang
authors.initials: J
authors.lastname: Zhang
authors.forename: Shuping
authors.initials: S
authors.lastname: Wang
authors.forename: Shoude
authors.initials: S
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Shan
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001763:Blepharoptosis / Q000139:chemically induced; D002374:Catalase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005979:Glutathione Peroxidase / Q000378:metabolism; D007035:Hypothermia / Q000139:chemically induced; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000502:physiology*; D018384:Oxidative Stress / Q000187:drug effects*; D012110:Reserpine / Q000009:adverse effects; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology; D013312:Stress, Physiological; D013482:Superoxide Dismutase / Q000378:metabolism; D013550:Swimming; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D012503:Saponins; D014315:Triterpenes; D012701:Serotonin; C442170:bacopaside I; D008315:Malondialdehyde; D012110:Reserpine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase; D009638:Norepinephrine
keywords: 5-HT; 5-HTP; 5-Hydroxytryptamine; 5-Hydroxytryptophan; Antidepressant-like effect; Antioxidant activation; Bacopaside I; CAT; Catalase; FST; Forced swim; Forced swim test; GSH-Px; Glutathione peroxidase; MAO; MDA; Malondialdehyde; Monoamine oxidase; NE; Noradrenaline; Noradrenergic; SOD; Superoxide dismutase; TST; Tail suspension; Tail suspension test