title: [New concepts for pressure-controlled glaucoma implants].
abstract: In industrialized countries glaucoma is one of the most common causes that leads to blindness. It is also the most common cause of irreversible blindness worldwide. In addition to local treatment of intraocular pressure and filtering glaucoma surgery, alloplastic implants are increasingly being used in glaucoma therapy. As long-term results published in the literature of commonly used implants are unsatisfactory, it seems useful to search for new concepts. In order to avoid the well-known short-term and long-term postoperative complications a pressure-controlled microstent with antiproliferative surface modifications was developed. Additionally, the functionality of such a microstent should be investigated using an animal glaucoma model. This paper describes the concept of a microstent which drains aquous humour from the anterior chamber into the suprachoroidal space. In addition, the glaucoma models described in the literature are discussed. Unfortunately, none of the methods could be reproduced permanently. First results show a correct implantation of a coated microstent with valve where the anti-proliferative effect could be demonstrated histologically. The promising results should lead to further investigations and the final goal will be the testing of the stent in the human eye.
authors.affiliation: Augenklinik, Universitätklinikum Rostock, Rostock, Deutschland. info@augenarzt-zufikon.ch
authors.forename: R
authors.initials: R
authors.lastname: Allemann
authors.forename: O
authors.initials: O
authors.lastname: Stachs
authors.forename: K
authors.initials: K
authors.lastname: Falke
authors.forename: W
authors.initials: W
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Siewert
authors.forename: K
authors.initials: K
authors.lastname: Sternberg
authors.forename: B
authors.initials: B
authors.lastname: Chichkov
authors.forename: A
authors.initials: A
authors.lastname: Wree
authors.forename: K-P
authors.initials: KP
authors.lastname: Schmitz
authors.forename: R F
authors.initials: RF
authors.lastname: Guthoff
mesh_terms: D019544:Equipment Failure Analysis; D019317:Evidence-Based Medicine; D005544:Forecasting; D005901:Glaucoma / Q000534:rehabilitation* / Q000601:surgery; D020327:Glaucoma Drainage Implants / Q000639:trends*; D006801:Humans; D044085:Microfluidics / Q000295:instrumentation* / Q000639:trends*; D011312:Pressure; D011474:Prosthesis Design / Q000639:trends; D015607:Stents / Q000639:trends*; D016896:Treatment Outcome