title: Genome-enabled methods for predicting litter size in pigs: a comparison.
abstract: Predictive ability of models for litter size in swine on the basis of different sources of genetic information was investigated. Data represented average litter size on 2598, 1604 and 1897 60K genotyped sows from two purebred and one crossbred line, respectively. The average correlation (r) between observed and predicted phenotypes in a 10-fold cross-validation was used to assess predictive ability. Models were: pedigree-based mixed-effects model (PED), Bayesian ridge regression (BRR), Bayesian LASSO (BL), genomic BLUP (GBLUP), reproducing kernel Hilbert spaces regression (RKHS), Bayesian regularized neural networks (BRNN) and radial basis function neural networks (RBFNN). BRR and BL used the marker matrix or its principal component scores matrix (UD) as covariates; RKHS employed a Gaussian kernel with additive codes for markers whereas neural networks employed the additive genomic relationship matrix (G) or UD as inputs. The non-parametric models (RKHS, BRNN, RNFNN) gave similar predictions to the parametric counterparts (average r ranged from 0.15 to 0.23); most of the genome-based models outperformed PED (r = 0.16). Predictive abilities of linear models and RKHS were similar over lines, but BRNN varied markedly, giving the best prediction (r = 0.31) when G was used in crossbreds, but the worst (r = 0.02) when the G matrix was used in one of the purebred lines. The r values for RBFNN ranged from 0.16 to 0.23. Predictive ability was better in crossbreds (0.26) than in purebreds (0.15 to 0.22). This may be related to family structure in the purebred lines.
authors.affiliation: 1 Department of Animal Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: L
authors.initials: L
authors.lastname: Tusell
authors.forename: P
authors.initials: P
authors.lastname: Pérez-Rodríguez
authors.forename: S
authors.initials: S
authors.lastname: Forni
authors.forename: X-L
authors.initials: XL
authors.lastname: Wu
authors.forename: D
authors.initials: D
authors.lastname: Gianola
mesh_terms: D000822:Animal Husbandry / Q000379:methods*; D000818:Animals; D001499:Bayes Theorem; D001947:Breeding / Q000379:methods*; D005260:Female; D016678:Genome; D016014:Linear Models; D008098:Litter Size; D008957:Models, Genetic; D016571:Neural Networks, Computer; D010375:Pedigree; D010641:Phenotype; D034421:Sus scrofa / Q000235:genetics / Q000502:physiology*