title: Cytochrome c and superoxide.
abstract: Wegerich et al. (J. Biol. Inorg. Chem. 18:429-440, 2013), working with singly modified human cytochromes c, claim to have found a new mechanism for the reduction of iron(III) cytochrome c by superoxide. I show that electron transfer by way of the solvent-accessible haem edge-a mechanism not considered by Wegerich et al.-is still the correct mechanism. Furthermore, several deficiencies in this work preclude any comparisons with other publications on this topic.
authors.affiliation: Institute of Inorganic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland, koppenol@inorg.chem.ethz.ch.
authors.forename: Willem H
authors.initials: WH
authors.lastname: Koppenol
mesh_terms: D000818:Animals; D003574:Cytochrome c Group / Q000737:chemistry*; D006801:Humans; D008239:Lysine / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry*
chemical_list: D003574:Cytochrome c Group; D013481:Superoxides; D008239:Lysine