title: 19F NMR: a valuable tool for studying biological events.
abstract: With the spectacular advancement of NMR techniques and the flourishing of fluorine chemistry allowing the synthesis of various fluorinated molecules, (19)F NMR represents a compelling option for studying myriad biological events ranging from the structure and function of biomolecules, enzymatic mechanisms, and metabolic pathways, through to drug screening and discovery as well as medical imaging. In this tutorial review, we aim to provide readers with a brief overview of the recent applications of (19)F NMR in various areas relating to biological and biomedical research, together with a brief introduction of specific hardware improvements permitting the practical implementation of (19)F NMR.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Han_Chen@hms.harvard.edu.
authors.forename: Han
authors.initials: H
authors.lastname: Chen
authors.forename: Stéphane
authors.initials: S
authors.lastname: Viel
authors.forename: Fabio
authors.initials: F
authors.lastname: Ziarelli
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D000818:Animals; D035843:Biomedical Research; D055808:Drug Discovery; D005461:Fluorine / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D009696:Nucleic Acids / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D009696:Nucleic Acids; D011506:Proteins; D005461:Fluorine