title: Application of diet-derived taste active components for clinical nutrition: perspectives from ancient Ayurvedic medical science, space medicine, and modern clinical nutrition.
abstract: The principal objective of this paper is to demonstrate the role of taste and flavor in health from the ancient science of Ayurveda to modern medicine; specifically their mechanisms and roles in space medicine and their clinical relevance in modern heath care. It also describes the brief history of the use of the monosodium glutamate or flavor enhancers ("Umami substance") that improve the quality of food intake by stimulating chemosensory perception. In addition, the dietary nucleotides are known to be the components of "Umami substance" and the benefit of their use has been proposed in various types of patients with cancer, radiation therapy, organ transplantation, and for application in space medicine.
authors.forename: Anil D
authors.initials: AD
authors.lastname: Kulkarni
authors.forename: Alamelu
authors.initials: A
authors.lastname: Sundaresan
authors.forename: Muhammad J
authors.initials: MJ
authors.lastname: Rashid
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: University of Texas Medical School, Houston, Texas 77030, USA. Anil.D.Kulkarni@uth.tmc.edu.
authors.forename: Francisco
authors.initials: F
authors.lastname: Karkow
mesh_terms: D000337:Aerospace Medicine / Q000379:methods / Q000639:trends*; D000818:Animals; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008515:Medicine, Ayurvedic; D015596:Nutrition Assessment; D012970:Sodium Glutamate / Q000008:administration & dosage; D013649:Taste / Q000187:drug effects / Q000502:physiology*
chemical_list: D012970:Sodium Glutamate