title: Boronic acid-containing hydrogels: synthesis and their applications.
abstract: Boronic acid-containing hydrogels are important intelligent materials. With the introduction of boronic acid functionality, these hydrogels exhibit a lot of interesting properties, such as glucose-sensitivity, reversibility and self-healing. These materials have found important applications in many areas, especially in biomedical areas. This paper aims to provide an overview of the current state of the art of the study in this area. We review the synthesis and properties of various boronic acid-containing hydrogels, including macroscopic hydrogels, microgels and layer-by-layer self-assembled films. Their applications were described, with an emphasis on the design of various glucose sensors and self-regulated insulin delivery devices. New development in this area was highlighted. Problems and the new directions were discussed.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. yongjunzhang@nankai.edu.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Guan
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D035843:Biomedical Research; D015374:Biosensing Techniques; D001709:Biotechnology; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D003692:Delayed-Action Preparations; D020100:Hydrogels