title: The emerging role of RNA polymerase I transcription machinery in human malignancy: a clinical perspective.
abstract: Ribosome biogenesis - the complex and highly coordinated cellular process leading to the production of ribosomes - is strictly dependent on the activity of RNA polymerase I (Pol I) transcriptional machinery. Pol I activity is continually increased in proliferating cells to sustain the increased demand for ribosome production and protein synthesis, which are necessary for appropriate cell growth and division. The integrity of the process of ribosome biogenesis represents an important sensor of cellular stress: when this process is altered, a tumor suppressor response is triggered, which leads to proliferative arrest. The present review focuses on the possible implications of Pol I targeting in the treatment of human malignancies.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, ItalyAlma Mater Studiorum, University of Bologna, Bologna, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Montanaro
authors.forename: Davide
authors.initials: D
authors.lastname: Treré
authors.forename: Massimo
authors.initials: M
authors.lastname: Derenzini
keywords: Pol I; RNA polymerase I inhibitors; cancer; cell cycle control; ribosome biogenesis