title: Synthesis of novel peptides through Ugi-ligation and their anti-cancer activities.
abstract: Proline-rich heptapeptide was synthesized and its structure was modified through Ugi-ligation. The desired pseudopeptides were separated as diastereomers and their anti-cancer activities were investigated. Their in vitro anti-cancer activities were investigated by treating HL60 (leukemia cancer cells), MCF7 (breast cancer cells) and A549 (lung cancer cells) cells with appropriate amounts of synthesized peptides. Our in vitro studies suggest that compounds 11a-b, 11i-j, and 11e had little or no effect on cancer cells viabilities.
authors.affiliation: Peptide Chemistry Research Center, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Tahoori
authors.forename: Reza
authors.initials: R
authors.lastname: Sheikhnejad
authors.forename: Saeed
authors.initials: S
authors.lastname: Balalaie
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Sadjadi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D061986:MCF-7 Cells; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009842:Oligopeptides