title: IL-1 and T Helper Immune Responses.
abstract: CD4 T cells play a critical role in mediating adaptive immunity to a variety of pathogens as well as in tumor immunity. If not adequately regulated, CD4 T cells can be also involved in autoimmunity, asthma, and allergic responses. During TCR activation in a particular cytokine milieu, naïve CD4 T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, and Th17, as defined by their pattern of cytokine production and function. IL-1, the prototypic proinflammatory cytokine, has been shown to influence growth and differentiation of immunocompetent lymphocytes. The differential expression of IL-1RI on human CD4 T cell subsets confers distinct capacities to acquire specific effector functions. In this review, we summarize the role of IL-1 on CD4 T cells, in terms of differentiation, activation, and maintenance or survival.
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence , Florence , Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Santarlasci
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cosmi
authors.forename: Laura
authors.initials: L
authors.lastname: Maggi
authors.forename: Francesco
authors.initials: F
authors.lastname: Liotta
authors.forename: Francesco
authors.initials: F
authors.lastname: Annunziato
keywords: IL-1 and T cells; IL-1RI and T cells; Th1 non-classic; Th17 cells; Th2 cells