title: Integration microarray and regulation datasets for Chronic Obstructive Pulmonary Disease.
abstract: BACKGROUND
  Pulmonary disease has become one of the major health problems.
  
  
  OBJECTIVE
  To investigate the regulation mechanism of Chronic Obstructive Pulmonary Disease (COPD) on gene expression and pathway level.
  
  
  METHODS
  We mapped the differentially expressed genes to a regulation network and pathways, using transcriptome profiles and regulation data. We constructed a TF-target gene regulation network, TF-pathway regulation network, and pathway crosstalk network.
  
  
  RESULTS
  STAT1, NFKB1, SMAD4, and STAT3 played an important role in COPD through participating in a number of pathways. Although these related pathways all have been demonstrated associated with COPD in previous reports, the detail mechanism may be not very clear.
  
  
  CONCLUSIONS
  Our results may help to further understanding the mechanism of COPD. And Identified multiple pathways will also provide novel avenues in the treatment of COPD.
authors.affiliation: Respiratory Department, Shanghai Jiaotong University, Shanghai, China.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Jin
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: C
authors.initials: C
authors.lastname: Shen
mesh_terms: D000465:Algorithms; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016208:Databases, Factual; D005786:Gene Expression Regulation; D006801:Humans; D046228:Microarray Analysis; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D020239:Receptor Cross-Talk / Q000502:physiology; D012907:Smoking / Q000009:adverse effects; D059467:Transcriptome