title: Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides.
abstract: Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a high selectivity.
authors.affiliation: Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Tokyo 113-8656, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyake
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Ota
authors.forename: Masashi
authors.initials: M
authors.lastname: Shibata
authors.forename: Kazunari
authors.initials: K
authors.lastname: Nakajima
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nishibayashi
mesh_terms: D002264:Carboxylic Acids; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D006219:Halogens; D012821:Silanes; D013876:Thiophenes; C550746:2-thiophene carboxylic acid; D003300:Copper