title: Efficacy of dexamethasone in the prophylaxis of nausea and vomiting during the postoperative period of laparoscopic cholecystectomy.
abstract: To verify the efficacy of dexamethasone in the prophylaxis of nausea and vomiting in patients submitted to laparoscopic cholecystectomy.
  
  
  
  This was a systematic review of the literature through the MEDLINE, Embase, and LILACS databases. Only controlled and randomized clinical trials comparing dexamethasone to placebo in the prophylaxis of nausea and vomiting in patients submitted to laparoscopic cholecystectomy were included.
  
  
  
  The results of this review were based on data from 12 controlled and randomized clinical trials, totaling 947 patients. The group of patients who received preoperative dexamethasone showed lower incidence of nausea (number needed to treat [NNT]=7), vomiting (NNT=7), and need for smaller doses of rescue antiemetics (NNT=6).
  
  
  
  The preoperative infusion of 8 mg of dexamethasone decreases the risk of complications in the postoperative period for patients submitted to laparoscopic cholecystectomy.
authors.affiliation: Associação Médica Brasileira, São Paulo, SP, Brazil. wmbernardo@usp.br
authors.forename: Wanderley Marques
authors.initials: WM
authors.lastname: Bernardo
authors.forename: Felipe Toyama
authors.initials: FT
authors.lastname: Aires
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D003907:Dexamethasone / Q000627:therapeutic use*; D006801:Humans; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011184:Postoperative Period; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000932:Antiemetics; D003907:Dexamethasone
keywords: Cholelithiasis; Colecistectomia laparoscópica; Colelitíase; Dexametasona; Dexamethasone; Laparoscopic cholecystectomy; Náusea e vômito pós-operatório; Postoperative nausea and vomiting