title: [First isolation in Argentina of community-acquired methicillin-resistant Staphylococcus aureus with intermediate susceptibility to vancomycin and nonsusceptibility to daptomycin].
abstract: We report the first case in Argentina of community-acquired methicillin-resistant Staphylococcus aureus with intermediate susceptibility to vancomycin and nonsusceptibility to daptomycin.
  
  
  METHODS
  A male patient with a history of chronic renal failure on hemodialysis and hip fracture osteosynthesis was admitted to hospital for persistent febrile syndrome following the displacement of the prosthesis by trauma. Blood cultures grew community-acquired methicillin-resistant Staphylococcus aureus. During treatment with vancomycin and daptomycin, a gradual increase in vancomycin MIC of 1 μg/ml (VSSA) to 2 μg/ml (h-VISA) and 4 μg/ml (VISA) was observed, as well as the emergence of non-susceptibility to daptomycin (MIC = 4 μg/ml). By suspending vancomycin and daptomycin, the strain reversed to the susceptible phenotype to both drugs. It is mandatory to evaluate by MIC the susceptibility to vancomycin and daptomycin during treatment when these drugs are used as therapy.
authors.affiliation: Sección Microbiología, Hospital General de Agudos J. A. Fernández, Ciudad Autónoma de Buenos Aires, Argentina. lerrecalde@yahoo.com.ar
authors.forename: Laura
authors.initials: L
authors.lastname: Errecalde
authors.forename: Paola
authors.initials: P
authors.lastname: Ceriana
authors.forename: Paula
authors.initials: P
authors.lastname: Gagetti
authors.forename: Mariana
authors.initials: M
authors.lastname: Erbín
authors.forename: Andrea
authors.initials: A
authors.lastname: Duarte
authors.forename: María
authors.initials: M
authors.lastname: J Rolón
authors.forename: Daniel
authors.initials: D
authors.lastname: Cuatz
authors.forename: Alejandra
authors.initials: A
authors.lastname: Corso
authors.forename: Sara
authors.initials: S
authors.lastname: Kaufman
mesh_terms: D001118:Argentina; D017714:Community-Acquired Infections / Q000382:microbiology*; D017576:Daptomycin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D014640:Vancomycin / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D014640:Vancomycin; D017576:Daptomycin