title: Evaluation of McDonald MRI criteria for dissemination in space in Korean patients with clinically isolated syndromes.
abstract: We investigated the validity of the 2005 and 2010 McDonald magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) to predict the conversion of clinically definite multiple sclerosis (CDMS) in 94 Korean patients with clinically isolated syndromes (CIS). The sensitivity, specificity, accuracy, positive and negative predictive values of the 2005, 2010 McDonald DIS criteria were comparable to those observed in the Caucasian population. This finding suggests that after careful exclusion of alternative explanations, particularly neuromyelitis optica (NMO) and NMO spectrum disorder (NMOSD), both the 2005 and 2010 McDonald DIS criteria are also useful to predict conversion to CDMS in Korean patients with CIS.
authors.affiliation: Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea.
authors.forename: So-Young
authors.initials: SY
authors.lastname: Huh
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Woojun
authors.initials: W
authors.lastname: Kim
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Lee
authors.forename: Min Su
authors.initials: MS
authors.lastname: Park
authors.forename: Suk-Won
authors.initials: SW
authors.lastname: Ahn
authors.forename: Byung-Jo
authors.initials: BJ
authors.lastname: Kim
authors.forename: Joong-Yang
authors.initials: JY
authors.lastname: Cho
authors.forename: Ho Jin
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D003711:Demyelinating Diseases / Q000175:diagnosis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D015203:Reproducibility of Results; D056910:Republic of Korea; D055815:Young Adult
keywords: MRI; Multiple sclerosis