title: [Carcinoembryonic antigen increased as initial manifestation of medullary thyroid cancer (report of 2 cases and review of the literature)].
abstract: OBJECTIVE
  To raise clinical awareness of carcinoembryonic antigen(CEA) increased as initial manifestation of medullary thyroid cancer(MTC) and explore the diagnosis and treatment.
  
  
  METHODS
  Clinical data of 2 cases CEA increased as the initial presentation of MTC were retrospectively analyzed and clinical manifestations of the disease, diagnosis, treatment were also discussed by literature reviewing.
  
  
  RESULTS
  Two patients received thyroid ipsilateral lobe total resection, MTC was confirmed by intraoperative frozen pathology, re-total resection of the contralateral lobe and bilateral VI lymph node dissection were performed. Lymph nodes had no metastasis confirmed by pathological frozen examination. CEA returned to normal within 2 months after surgery. No tumor recurrence and metastasis were found after follow-up for 3 to 24 months.
  
  
  CONCLUSIONS
  CEA increased as the initial presentation MTC was rare and clinical identification of CEA increased disease should be taken into account the MTC as possible. Total thyroidectomy and bilateral VI lymph node dissection was the main surgical treatment for it.
authors.affiliation: Department of Head and Neck, Tumor Hospital of Ganzhou, Ganzhou, 341000, China.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Lan
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.forename: Keqin
authors.initials: K
authors.lastname: Luo
authors.forename: Keqiang
authors.initials: K
authors.lastname: Tian
authors.forename: Guoxing
authors.initials: G
authors.lastname: Zeng
authors.forename: Shaojin
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D002272:Carcinoembryonic Antigen / Q000378:metabolism*; D018278:Carcinoma, Neuroendocrine; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D002272:Carcinoembryonic Antigen