title: Lack of association between Fas rs180082 polymorphism and risk of cervical cancer: an update by meta-analysis.
abstract: BACKGROUND
  The Fas rs180082 polymorphism has been reported to be associated with cervical cancer susceptibility, yet the results of these previous results have been inconsistent or controversial. The objective of this study was to explore whether the Fas rs180082 polymorphism confers susceptibility to cervical cancer.
  
  
  METHODS
  The relevant studies were identified through a search of PubMed, Excerpta Medica Database (Embase), Elsevier Science Direct and Chinese Biomedical Literature Database (CBM) until July 2012. The association between the Fas rs180082 polymorphism and cervical cancer risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs).
  
  
  RESULTS
  A total of 7 case-control studies were eventually identified. We found no association between Fas rs180082 polymorphism and cervical cancer susceptibility in overall population (G versus A: OR = 1.03, 95% CI = 0.99-1.07, P = 0.197; AG + GG versus AA: OR = 1.04, 95% CI = 0.98-1.09, P = 0.176; GG versus AA + AG: OR = 1.04, 95% CI = 0.84-1.31, P = 0.701). In subgroup analysis, similar results were found in Asian (G versus A: OR = 1.06, 95% CI = 0.97-1.15, P = 0.195; AG + GG versus AA: OR = 1.08, 95% CI = 0.98-1.19, P = 0.176; GG versus AA + AG: OR = 0.97, 95% CI = 0.51-1.84, P = 0.935) and African (G versus A: OR = 1.01, 95% CI = 0.97-1.15, P = 0.195; AG + GG versus AA: OR = 0.99, 95% CI = 0.91-1.07, P = 0.739; GG versus AA + AG: OR = 1.09, 95% CI = 0.94-1.25, P = 0.745).
  
  
  CONCLUSIONS
  This meta-analysis has shown that there is a lack of association of the Fas rs180082 polymorphisms with cervical cancer susceptibility. However, larger scale primary studies with the consideration of gene-gene and gene-environment interactions are still required to further evaluate the interaction of Fas rs180082 polymorphism with cervical cancer susceptibility.
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.forename: Wuning
authors.initials: W
authors.lastname: Mo
authors.forename: Qiliu
authors.initials: Q
authors.lastname: Peng
authors.forename: Xiandu
authors.initials: X
authors.lastname: Su
mesh_terms: D017209:Apoptosis; D044466:Asian People / Q000235:genetics; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D019014:fas Receptor / Q000235:genetics*
chemical_list: C491901:FAS protein, human; D019014:fas Receptor