title: Regeneration of neuronal cells following cerebral injury.
abstract: Stem cells possess a definitive role in neuronal rejuvenation following a cerebral injury. Whether endogenous, from the neurogenic niches of the subventricular zone and subgranular zone, or recruited from the bone marrow through peripheral circulation, accumulating evidence demonstrates that stem cells ameliorate the consequences of cerebrovascular events, particularly cerebral ischemia. In this chapter, we review milestone studies implicating the role of stem cells in response to disease. Furthermore, we outline specific mechanisms of action along with their clinical potential as therapeutic treatments for ischemic stroke.
authors.affiliation: Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL 33612, USA.
authors.forename: Travis
authors.initials: T
authors.lastname: Dailey
authors.forename: Naoki
authors.initials: N
authors.lastname: Tajiri
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Borlongan
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D012038:Regeneration / Q000502:physiology; D013234:Stem Cells / Q000473:pathology / Q000502:physiology*