title: Protection of astaxanthin in astaxanthin nanodispersions using additional antioxidants.
abstract: The protective effects of α-tocopherol and ascorbic acid on astaxanthin in astaxanthin nanodispersions produced via a solvent-diffusion technique and stabilized by a three-component stabilizer system, were studied either individually or in combination by using response surface methodology. Generally, both α-tocopherol and ascorbic acid could retard the astaxanthin degradation in astaxanthin nanodispersions. The results showed that the using α-tocopherol and ascorbic acid can be more efficient in increasing the chemical stability of nanodispersions in comparison to using them individually. Using a response surface methodology (RSM) response optimizer, it was seen that addition of ascorbic acid (ascorbic acid/astaxanthin w/w) and α-tocopherol (α-tocopherol/astaxanthin w/w) in proportions of 0.4 and 0.6, respectively, would give the maximum chemical stability to the studied astaxanthin nanodispersions.
authors.affiliation: Department of Engineering, East Azarbaijan Science and Research Branch, Islamic Azad University, Tabriz 1547, Iran. anarjan@iauasrb.ac.ir
authors.forename: Navideh
authors.initials: N
authors.lastname: Anarjan
authors.forename: Imededdine Arbi
authors.initials: IA
authors.lastname: Nehdi
authors.forename: Chin Ping
authors.initials: CP
authors.lastname: Tan
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry*; D015227:Lipid Peroxidation; D049329:Nanostructures / Q000737:chemistry; D024341:Xanthophylls / Q000138:chemical synthesis / Q000737:chemistry; D024502:alpha-Tocopherol / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D024341:Xanthophylls; C005948:astaxanthine; D024502:alpha-Tocopherol; D001205:Ascorbic Acid