title: The association between peritoneal charge barrier dysfunction and protein lost during continuous ambulatory peritoneal dialysis.
abstract: OBJECTIVE
  The main purpose of the present study was to determine the effect of peritoneal charge barrier dysfunction on hypoalbuminemia during CAPD.
  
  
  METHODS
  We measured the association of dialysis dose, peritoneal equilibration test (PET) results (ratio of dialysate and plasma creatinine), and peritoneal charge barrier index (ratio of pancreatic and salivary α-amylase clearance) on protein loss in 33 patients on maintenance CAPD. All patients were from a single institution and were diagnosed with chronic nephritis (n = 18 cases), diabetic nephropathy (n = 8), hypertension (n = 5), and hepatitis B virus-associated glomerulonephritis (n = 2).
  
  
  RESULTS
  The mean (± SD) dialysate protein loss was 4.04 g (± 1.97) per day. Protein loss was positively correlated with dialysis dose (r = 0.438, p = 0.01) but was not significantly correlated with PET results. The mean (± SD) peritoneal charge barrier index was 6.12 (± 21.20) and was inversely correlated with protein loss into the peritoneal dialysate (r = -0.532, p < 0.01).
  
  
  CONCLUSIONS
  Taken together, our study of CAPD patients indicates that protein loss into the peritoneal dialysate increases with peritoneal dialysis dose and with disruption of the peritoneal charge barrier. © 2013 S. Karger AG, Basel.
authors.affiliation: Department of Nephrology, Dong Fang Hospital, Fuzhou City, Fujian Province, China.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Yu
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D015314:Dialysis Solutions / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015314:Dialysis Solutions; D003404:Creatinine