title: Abundant daily non-sedentary activity is associated with reduced prevalence of metabolic syndrome and insulin resistance.
abstract: BACKGROUND
  Non-exercise activity thermogenesis has recently drawn attention because of its potential to prevent weight gain.
  
  
  OBJECTIVE
  This study evaluated the relationships between the duration of daily non-sedentary activities and the prevalence of metabolic syndrome and insulin resistance (IR) in the Japanese population.
  
  
  METHODS
  A total of 518 eligible subjects (380 men and 138 women) who attended the Tokushima Prefectural General Health Checkup Center and participated in the baseline survey of a cohort study conducted in Tokushima Prefecture, Japan were analyzed. Information about lifestyle characteristics including leisure-time exercise and daily non-exercise activities was obtained from a questionnaire. Logistic and multiple linear regression analyses were performed to evaluate the associations between the duration of daily non-exercise non-sedentary activities (beyond sitting) and prevalence of metabolic syndrome (and its components) and IR.
  
  
  RESULTS
  Subjects with longer duration of daily non-sedentary activities had significantly lower adjusted odds ratios for metabolic syndrome (p for trend =0.024), abdominal obesity (p for trend =0.023), and low HDLcholesterol levels (p for trend =0.002), after adjustment for sex, age, and other probable covariates including leisure-time exercise. Longer duration of daily non-sedentary activities was further associated with lower homeostasis model of assessment- IR (HOMA-IR) values (p for trend =0.009).
  
  
  CONCLUSIONS
  Our results suggest that abundant daily non-sedentary activity might be associated with a lower prevalence of metabolic syndrome, especially for the components of central obesity and low HDL-cholesterol levels, and with a lower prevalence of IR, independent of leisure-time exercise.
authors.affiliation: Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto- cho, Tokushima 770-8503, Japan. uemura@basic.med.tokushima-u.ac.jp.
authors.forename: H
authors.initials: H
authors.lastname: Uemura
authors.forename: S
authors.initials: S
authors.lastname: Katsuura-Kamano
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Nakamoto
authors.forename: M
authors.initials: M
authors.lastname: Hiyoshi
authors.forename: K
authors.initials: K
authors.lastname: Arisawa
mesh_terms: D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D057185:Sedentary Behavior
chemical_list: D008076:Cholesterol, HDL