title: Association between serum anti-Müllerian hormone level and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the correlation between serum levels of anti-Müllerian hormone (AMH) and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Seventy-four cycles of mild stimulation (clomiphene citrate+gonadotropin followed by timed intercourse or intrauterine insemination) performed in normoovulatory women (57 cycles) and anovulatory women with PCOS (17 cycles). Ovarian sensitivity was defined by the number of mature follicles (≥14 mm) on triggering day per 100 IU of gonadotropin. A correlation between ovarian sensitivity and the baseline serum AMH level (absolute or multiples of the median [MoM] value for each corresponding age) was calculated. Correlation between ovarian response and serum AMH level was evaluated.
  
  
  RESULTS
  Ovarian sensitivity to mild stimulation was positively correlated with absolute serum AMH (r=0.535, p<0.001) or AMH-MoM value (r=0.390, p=0.003) in normoovulatory women, but this correlation was not observed in anovulatory women with PCOS (r=0.105, p>0.05, r=-0.265, p>0.05, respectively).
  
  
  CONCLUSIONS
  Ovarian response to mild stimulation is possibly predicted by the serum AMH level in normoovulatory women, but not in anovulatory women with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Ju Yeong
authors.initials: JY
authors.lastname: Kim
authors.forename: Gwang
authors.initials: G
authors.lastname: Yi
authors.forename: Yeo Rang
authors.initials: YR
authors.lastname: Kim
authors.forename: Jae Yeon
authors.initials: JY
authors.lastname: Chung
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Ahn
authors.forename: You Kyoung
authors.initials: YK
authors.lastname: Uhm
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Jee
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Suh
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
keywords: Anti-Müllerian hormone; Ovarian stimulation; Polycystic ovary syndrome