title: A dual role for sirtuin 1 in tumorigenesis.
abstract: Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal physiological and pathological processes. In addition to its place in cellular energy metabolism, increasing evidence shows a role for SIRT1 in tumorigenesis, wherein it can function as either a tumor promoter or suppressor. Its function in malignancy varies with concentration, cellular location, temporal and spatial distribution, and regulation by upstream and downstream factors. In this mini-review, we present the existing data which implicates SIRT1 in tumorigenesis.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Surgery, University of Missouri, One Hospital Drive, MC520E, DC116.94, Columbia, MO 65212, USA. nichollm@health.missouri.edu.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Nicholl
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D006801:Humans; D056564:Sirtuin 1 / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: D025521:Tumor Suppressor Proteins; D056564:Sirtuin 1