title: A novel chiral bisphosphine-thiourea ligand for asymmetric hydrogenation of β,β-disubstituted nitroalkenes.
abstract: A novel chiral bisphosphine-thiourea ligand was developed and applied in the highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes (up to 99% yield and 99% ee). With low catalytic loading (0.25 mol %), 98% ee and 98% conversion were obtained. The thiourea group takes on an important role in this catalytic system.
authors.affiliation: School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Shengkun
authors.initials: S
authors.lastname: Li
authors.forename: Kexuan
authors.initials: K
authors.lastname: Huang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D006865:Hydrogenation; D008024:Ligands; D009574:Nitro Compounds / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000475:Alkenes; D008024:Ligands; D009574:Nitro Compounds; D009943:Organophosphorus Compounds; D013890:Thiourea