title: Association of ADRB2 polymorphism with triglyceride levels in Tongans.
abstract: BACKGROUND
  Our previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic populations.
  
  
  METHODS
  To investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga.
  
  
  RESULTS
  A multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly associated with triglyceride levels (P-value = 0.037). A copy of the rs34623097-A allele increased serum triglyceride levels by 70.1 mg/dL (0.791 mmol/L). None of the ADRB2 SNPs showed a significant association with total-cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol.
  
  
  CONCLUSIONS
  In a Tongan population, a SNP located in the upstream region of ADRB2 is associated with triglyceride levels independent of body mass index.
authors.forename: Izumi
authors.initials: I
authors.lastname: Naka
authors.forename: Jun
authors.initials: J
authors.lastname: Ohashi
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kimura
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Inaoka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsumura
mesh_terms: D015992:Body Mass Index; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000235:genetics; D008077:Lipoproteins, LDL / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D014058:Tonga; D014280:Triglycerides / Q000097:blood* / Q000235:genetics*
chemical_list: C553443:ADRB2 protein, human; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D018343:Receptors, Adrenergic, beta-2; D014280:Triglycerides