title: Evaluation of a new vaccination program for infants born to HBsAg-positive mothers in Stockholm County.
abstract: To overcome previous shortcomings in the routines for prophylaxis to newborns of hepatitis B infected pregnant women, we established a new program in 2005. This program combined monovalent hepatitis B vaccine at birth and at one month with three doses of hexavalent vaccine, including a hepatitis B vaccine component, at 3, 5 and 12 months, respectively. The hexavalent vaccine and follow-up serologies were administered at the well baby clinics. Three hundred and eighty babies born to 356 HBsAg positive mothers (9% HBeAg positive), were evaluated. Twenty-two children were lost to follow-up, 329 of the remaining 358 children (92%) completed follow-up serology at ages 13-18 months, with protective anti-HBs levels in 99%. For comparison, in a previous cohort from 2000 to 2001, only 63% completed follow-up serology. We conclude that the adherence to the new program was good and that it resulted in a very high rate of protective antibody levels.
authors.affiliation: Department of Communicable Disease Control and Prevention, Stockholm County Council, Stockholm, Sweden.
authors.forename: Mona
authors.initials: M
authors.lastname: Insulander
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Hökeberg
authors.forename: Gudrun
authors.initials: G
authors.lastname: Lind
authors.forename: Madeleine
authors.initials: M
authors.lastname: von Sydow
authors.forename: Susanne
authors.initials: S
authors.lastname: Lindgren
authors.forename: Ingvor
authors.initials: I
authors.lastname: Petersson
authors.forename: Björn
authors.initials: B
authors.lastname: Fischler
mesh_terms: D004334:Drug Administration Schedule; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000627:therapeutic use*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D017589:Immunization Programs / Q000379:methods*; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D009035:Mothers; D011247:Pregnancy; D013548:Sweden; D014611:Vaccination
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines
keywords: Hepatitis B; Hexavalent; Mother-to-infant transmission; Vaccine