title: Effects of running wheel training on adult obese rats programmed by maternal prolactin inhibition.
abstract: The inhibition of maternal prolactin production in late lactation leads to metabolic syndrome and hypothyroidism in adult offspring. Physical training is a therapeutic strategy that could prevent or reverse this condition. We evaluated the effects of a short-duration low-intensity running wheel training program on the metabolic and hormonal alterations in rats. Lactating Wistar rats were treated with bromocriptine (Bro, 1 mg twice a day) or saline on days 19, 20, and 21 of lactation, and the training of offspring began at 35 days of age. Offspring were divided into sedentary and trained controls (C-Sed and C-Ex) and sedentary and trained Bro-treated rats (Bro-Sed and Bro-Ex). Chronic exercise delayed the onset of weight gain in Bro-Ex offspring, and the food intake did not change during the experimental period. At 180 days, visceral fat mass was higher (+46%) in the Bro-Sed offspring than in C-Sed and Bro-Ex rats. As expected, running capacity was higher in trained animals. Most parameters observed in the Bro-Sed offspring were consistent with hypothyroidism and metabolic syndrome and were reversed in the Bro-Ex group. Chronic exercise did not influence the muscle glycogen in the C-Ex group; however, liver glycogen was higher (+30%) in C-Ex group and was unchanged in both Bro offspring groups. Bro-Ex animals had higher plasma lactate dehydrogenase levels, indicating skeletal muscle damage and intolerance of the training program. Low-intensity chronic training is able to normalize many clinical aspects in Bro animals; however, these animals might have had a lower threshold for exercise adaptation than the control rats.
authors.affiliation: Departamento de Ciências Fisiológicas, 5° Andar, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Avenida 28 de Setembro, 87, Rio de Janeiro 20551-030, Brazil.
authors.forename: G
authors.initials: G
authors.lastname: Boaventura
authors.forename: G
authors.initials: G
authors.lastname: Casimiro-Lopes
authors.forename: C C
authors.initials: CC
authors.lastname: Pazos-Moura
authors.forename: E
authors.initials: E
authors.lastname: Oliveira
authors.forename: P C
authors.initials: PC
authors.lastname: Lisboa
authors.forename: E G
authors.initials: EG
authors.lastname: Moura
mesh_terms: D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D005260:Female; D006003:Glycogen / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007774:Lactation / Q000187:drug effects; D050356:Lipid Metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000517:prevention & control; D009035:Mothers; D009043:Motor Activity; D009132:Muscles / Q000737:chemistry; D009765:Obesity / Q000503:physiopathology*; D010805:Physical Conditioning, Animal; D011388:Prolactin / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D014886:Weaning
chemical_list: D001971:Bromocriptine; D011388:Prolactin; D006003:Glycogen; D007770:L-Lactate Dehydrogenase
keywords: early weaning; exercise; lipid profile; programming; prolactin; running wheel