title: In vitro analysis of the anti-cancer activity of mitoxantrone loaded on magnetic nanoparticles.
abstract: In this study, the anti-tumor activity of mitoxantrone loaded on magnetic nanoparticles (MTMP) was examined using DU145 prostate cancer cells. Composite nanoparticles with an average size of 20 nm were prepared using a chemical co-precipitation technique. The MTMP nanoparticles were cytotoxic to DU145 cells and inhibited cell proliferation. The expression levels of apoptosis related proteins in DU145 cells, including PARP and caspase 3, were increased after MTMP treatment. In this study, the therapeutic potential of MTMP in targeted-therapy against prostate cancer was demonstrated and MTMP was more effective when coupled to drug delivery vehicle than pure mitoxantrone.
authors.affiliation: Department of Advanced Materials Engineering, Daejeon University, Daejeon 300-716, Korea.
authors.forename: Kwon-Jai
authors.initials: KJ
authors.lastname: Lee
authors.forename: Jeung Hee
authors.initials: JH
authors.lastname: An
authors.forename: Je-Ran
authors.initials: JR
authors.lastname: Chun
authors.forename: Kang-Hyun
authors.initials: KH
authors.lastname: Chung
authors.forename: Woo-Yoon
authors.initials: WY
authors.lastname: Park
authors.forename: Jae-Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Dong-Hee
authors.initials: DH
authors.lastname: Kim
authors.forename: Young Yil
authors.initials: YY
authors.lastname: Bahk
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage* / Q000737:chemistry; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D008942:Mitoxantrone