title: Assessment of pulmonary oxygen toxicity: relevance to professional diving; a review.
abstract: When breathing oxygen with partial oxygen pressures PO₂ of between 50 and 300 kPa pathological pulmonary changes develop after 3-24h depending on the PO₂. This kind of injury (known as pulmonary oxygen toxicity) is not only observed in ventilated patients but is also considered an occupational hazard in oxygen divers or mixed gas divers. To prevent these latter groups from sustaining irreversible lesions adequate prevention is required. This review summarizes the pathophysiological effects on the respiratory tract when breathing oxygen with PO₂ of 50-300 kPa (hyperoxia). We discuss to what extent the most commonly used lung function parameters change after exposure to hyperoxia and its role in monitoring the onset and development of pulmonary oxygen toxicity in daily practice. Finally, new techniques in respiratory medicine are discussed with regard to their usefulness in monitoring pulmonary oxygen toxicity in divers.
authors.affiliation: Diving Medical Center, Royal Netherlands Navy, The Netherlands; Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands. Electronic address: Pjam.v.ooij.01@mindef.nl.
authors.forename: P J A M
authors.initials: PJ
authors.lastname: van Ooij
authors.forename: M W
authors.initials: MW
authors.lastname: Hollmann
authors.forename: R A
authors.initials: RA
authors.lastname: van Hulst
authors.forename: P J
authors.initials: PJ
authors.lastname: Sterk
mesh_terms: D004242:Diving / Q000009:adverse effects*; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D010100:Oxygen / Q000009:adverse effects* / Q000097:blood
chemical_list: D010100:Oxygen
keywords: Divers; Human; Lung function; Pathology; Pulmonary oxygen toxicity; assessment