title: Benzo{a}pyrene-induced DNA damage in Mytilus galloprovincialis: measurement of bulky DNA adducts and DNA oxidative damage in terms of 8-oxo-7,8-dihydro-2´-deoxyguanosine formation.
abstract: Bulky DNA adducts and 8-oxo-7,8-dihydro-2´-deoxyguanosine (8-oxodGuo) were measured in gill DNA of benzo[a]pyrene (B[a]P)-exposed mussels (50 mg kg(-1) dw day(-1)), respectively by the (32)P-post-labelling technique and high performance liquid chromatography coupled to electrochemical detection assay. A time-course study was performed for both biomarkers and their potential use for marine biomonitoring discussed for the sentinel species studied. In gills, B[a]P-related DNA adducts were positively correlated with B[a.
authors.affiliation: Laboratoire de Physico- et Toxicochimie des Systèmes Naturels, UPRESA 5472 CNRS, Université de Bordeaux I, Avenue des Facultés, 33405 Talence, France.
authors.lastname: F Akcha S Ruiz C Zampieron P Venier T Burgeot J Cadet J F Narbonne