title: Targeting of human antigen-presenting cell subsets.
abstract: Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demonstrating that Nbs represent a powerful tool to redirect lentivectors to human antigen-presenting cell subsets.
authors.affiliation: Laboratory of Molecular and Cellular Therapy, Department of Immunology-Physiology, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Cleo
authors.initials: C
authors.lastname: Goyvaerts
authors.forename: Jozef
authors.initials: J
authors.lastname: Dingemans
authors.forename: Kurt
authors.initials: K
authors.lastname: De Groeve
authors.forename: Carlo
authors.initials: C
authors.lastname: Heirman
authors.forename: Ellen
authors.initials: E
authors.lastname: Van Gulck
authors.forename: Guido
authors.initials: G
authors.lastname: Vanham
authors.forename: Patrick
authors.initials: P
authors.lastname: De Baetselier
authors.forename: Kris
authors.initials: K
authors.lastname: Thielemans
authors.forename: Geert
authors.initials: G
authors.lastname: Raes
authors.forename: Karine
authors.initials: K
authors.lastname: Breckpot
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D005822:Genetic Vectors / Q000378:metabolism*; D006801:Humans; D016086:Lentivirus / Q000235:genetics* / Q000378:metabolism*; D008198:Lymph Nodes / Q000276:immunology; D061905:Single-Domain Antibodies / Q000378:metabolism*
chemical_list: D061905:Single-Domain Antibodies