title: Flavan-3-ol-cysteine and acetylcysteine conjugates from edible reagents and the stems of Cynomorium songaricum as potent antioxidants.
abstract: Flavan-3-ol derivatives, including 3 cysteine conjugates and 3 acetylcysteine conjugates, were prepared using Cynomorium songaricum and edible reagents. The structures were determined, based on NMR and MS spectra. All compounds had stronger radical-scavenging activity than catechin and epicatechin. Moreover, the cysteine conjugates were active against α-glucosidase, whereas catechin and epicatechin were not. Two acetylcysteine flavan-3-ol conjugates, 4β-(L-acetylcysteinyl)-epicatechin 3-O-gallate and 4β-(L-acetylcysteinyl)-epiafzelechin, are novel compounds with better logP values than their cysteine counterparts. These conjugates can be prepared from purified flavan-3-ol polymers or directly from herbal material.
authors.affiliation: College of Life Sciences, Inner Mongolia University, Huhhot, Inner Mongolia, China.
authors.forename: Hao-Cong
authors.initials: HC
authors.lastname: Meng
authors.forename: Chao-Mei
authors.initials: CM
authors.lastname: Ma
mesh_terms: D000111:Acetylcysteine / Q000737:chemistry*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D031482:Cynomorium / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010936:Plant Extracts; C404987:flavan-3-ol; D003545:Cysteine; D000111:Acetylcysteine
keywords: Acetylcysteine conjugates; Antioxidant; Cynomorium songaricum; Cysteine conjugates; Flavan-3-ols; α-Glucosidase inhibitory activity