title: A case of dual infection in a paediatric trauma victim of primary cutaneous aspergillosis caused by Aspergillus flavus and Aspergillus terreus.
abstract: Aspergillus spp. are widely distributed throughout the environment. They are opportunistic pathogens causing infection at various sites in the body such as lungs, sinuses, eyes, skin, central nervous system etc., Primary cutaneous aspergillosis is an uncommon disease entity. Primary infections usually occur at sites having disruption of the skin and usually occur in burn patients, trauma and surgical patients. A 4-year-old girl who was run over by a truck and suffered extensive de-gloving injury to bilateral lower limbs developed greenish discharge and scaly lesions around the wound margins after 50 days of hospital stay. The skin biopsy demonstrated the presence of thin septate hyphae branching at acute angles and culture demonstrated growth of Aspergillus flavus and Aspergillus terreus. The child was started on voriconazole therapy for 3 weeks and the lesion healed satisfactorily. Subsequent skin biopsy culture was negative for fungi. Prompt diagnosis and management of such cases can salvage the limbs in severe trauma cases.
authors.affiliation: Department of Laboratory Medicine, JPNA Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: V
authors.initials: V
authors.lastname: Tak
authors.forename: P
authors.initials: P
authors.lastname: Mathur
authors.forename: I
authors.initials: I
authors.lastname: Xess
authors.forename: P
authors.initials: P
authors.lastname: Kale
authors.forename: S
authors.initials: S
authors.lastname: Sagar
authors.forename: M C
authors.initials: MC
authors.lastname: Misra
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000382:microbiology; D001230:Aspergillus / Q000145:classification / Q000302:isolation & purification*; D001706:Biopsy; D002675:Child, Preschool; D060085:Coinfection / Q000175:diagnosis* / Q000382:microbiology; D003881:Dermatomycoses / Q000175:diagnosis* / Q000382:microbiology; D005260:Female; D006801:Humans; D011743:Pyrimidines / Q000627:therapeutic use; D012867:Skin / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole