title: [Prognostic associations of preoperative plasma levels of fibrinogen and D-dimer after curative resection in patients with colorectal cancer].
abstract: OBJECTIVE
  To explore the associations of preoperative plasma levels of fibrinogen and D-dimer with clinicopathologic parameters and overall survival in colorectal cancer patients after curative resection.
  
  
  METHODS
  From January 2002 to December 2003, a total of 341 colorectal cancer patients underwent curative resection. And their relevant clinical data were reviewed. The median age was 58 years (range: 23 - 90 years) and the median follow-up period was 64 months (range: 5 - 89 months). The preoperative plasma levels of fibrinogen and D-dimer were examined, the correlation of clinicopathologic findings and overall survival was analyzed. A Log-rank test was used for univariate analysis and a Cox regression model for multivariate analysis.
  
  
  RESULTS
  The preoperative plasma levels of fibrinogen and D-dimer were (3.7 ± 0.7) g/L and (0.49 ± 0.18) mg/L respectively. Elevated plasma levels of fibrinogen were associated with advanced tumor stage (P = 0.008), venous invasion (P = 0.006), postoperative distant metastases (P < 0.01) and lymph node involvement (P = 0.001), but not with histologic grade (P = 0.232), and invasion depth (P = 0.253). The overall survival is 64.5% (220/341). Elevated plasma levels of D-dimer were associated with advanced tumor stage (P = 0.013), invasion depth (P = 0.007) and lymph node involvement (P = 0.001), but not with histologic grade (P = 0.082), venous invasion (P = 0.746) or postoperative distant metastases (P = 0.131). Multivariate analysis showed that preoperative plasma levels of fibrinogen (P = 0.029), histologic grade (P = 0.001), and lymph node involvement (P = 0.001) were independent prognostic factors.
  
  
  CONCLUSIONS
  High preoperative plasma levels of fibrinogen and D-dimer are associated with clinicopathologic parameters. And a high preoperative plasma level of fibrinogen is associated with distant metastases and poor prognosis after curative resection in colorectal cancer patients.
authors.affiliation: Tianjin Medical University Cancer Hospital, Tianjin, China.
authors.forename: Jun-feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Guo
authors.forename: Liang
authors.initials: L
authors.lastname: Tang
authors.forename: Jian-sheng
authors.initials: JS
authors.lastname: Guo
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Jian-zhong
authors.initials: JZ
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011184:Postoperative Period; D011379:Prognosis; D055815:Young Adult
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen