title: Assessment of palmitoyl and sulphate conjugated glycol chitosan for development of polymeric micelles.
abstract: BACKGROUND
  Amphiphilic copolymers are capable of forming core shell-like structures at the critical micellar concentration (CMC); hence, they can serve as drug carriers. Thus, in the present work, polymeric micelles based on novel chitosan derivative were synthesized.
  
  
  METHODS
  Block copolymer of palmitoyl glycol chitosan sulfate (PGCS) was prepared by grafting palmitoyl and sulfate groups serving as hydrophobic and hydrophilic fractions, respectively. Then, fourier transform infrared spectra (FTIR) and spectral changes in iodine/iodide mixture were carried out.
  
  
  RESULTS
  FTIR studies confirmed the formation of palmitoyl glycol chitosan sulfate (PGCS) and spectral changes in iodine/iodide mixture indicated CMC which lies in the range of 0.003-0.2 mg/ml.
  
  
  CONCLUSIONS
  Therefore, our study indicated that polymeric micelles based on palmitoyl glycol chitosan sulphate could be used as a prospective carrier for water insoluble drugs.
authors.affiliation: College of Pharmacy, Government College University, Faisalabad, Pakistan ; Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67400 Illkirch, France.
authors.forename: Ikram
authors.initials: I
authors.lastname: Ullah Khan
authors.forename: Gohar
authors.initials: G
authors.lastname: Ayub
authors.forename: Nazar M
authors.initials: NM
authors.lastname: Ranjha
keywords: Chlorosulfonic Acid; Glycol Chitosan; Palmitic Acid N-hydroxysuccinimde Ester; Palmitoyl Glycol Chitosan Sulfate; Polymeric Micelles