title: Two new chiratane-type triterpenoids from Swertia kouitchensis.
abstract: Two rare new chiratane-type triterpenoids, kouitchenoids A and B (1, 2), together with oleanolic acid (3) and ursolic acid (4), were isolated from ethanol extract of Swertia kouitchensis. The new structures were determined by the analysis of MS and NMR data. In addition, compounds 1-4 showed moderate inhibitory activity against the α-glucosidase (with IC₅₀ values ranging from 1,812 to 2,027 μM).
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Luo-Sheng
authors.initials: LS
authors.lastname: Wan
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Liu
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Lin
authors.forename: Qiu-Xia
authors.initials: QX
authors.lastname: Min
authors.forename: Jia-Chun
authors.initials: JC
authors.lastname: Chen
mesh_terms: D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D029967:Swertia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D000097245:Ursolic Acid
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D009828:Oleanolic Acid; D010936:Plant Extracts; D014315:Triterpenes; D000097245:Ursolic Acid