title: Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine.
abstract: A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
authors.forename: Ji
authors.initials: J
authors.lastname: Cai
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Lin
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.forename: Ji-Chang
authors.initials: JC
authors.lastname: Xiao
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D003653:Decarboxylation; D008958:Models, Molecular; D015394:Molecular Structure; D010755:Organophosphates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000085:Acetates; D000447:Aldehydes; D010755:Organophosphates; D009943:Organophosphorus Compounds; C072794:chlorodifluoroacetic acid; C005445:triphenyl phosphate