title: Effect of pulmonary surfactant on antimicrobial activity in vitro.
abstract: Time-kill curve experiments were performed with linezolid, doripenem, tigecycline, moxifloxacin, and daptomycin against Staphylococcus aureus and with colistin, moxifloxacin, and doripenem against Pseudomonas aeruginosa to evaluate the effect of porcine pulmonary surfactant on antimicrobial activity. Pulmonary surfactant significantly impaired the activities of moxifloxacin and colistin. When antibiotics are being developed for respiratory tract infections, the method described here might be used to preliminarily quantify the effect of pulmonary surfactant on antimicrobial activity.
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Schwameis
authors.forename: Z
authors.initials: Z
authors.lastname: Erdogan-Yildirim
authors.forename: M
authors.initials: M
authors.lastname: Manafi
authors.forename: M A
authors.initials: MA
authors.lastname: Zeitlinger
authors.forename: S
authors.initials: S
authors.lastname: Strommer
authors.forename: R
authors.initials: R
authors.lastname: Sauermann
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D003091:Colistin / Q000494:pharmacology; D017576:Daptomycin / Q000494:pharmacology; D000077726:Doripenem; D024841:Fluoroquinolones; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D000077266:Moxifloxacin; D023303:Oxazolidinones / Q000494:pharmacology; D011663:Pulmonary Surfactants / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013552:Swine; D000078304:Tigecycline
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D001372:Aza Compounds; D015780:Carbapenems; D024841:Fluoroquinolones; D023303:Oxazolidinones; D011663:Pulmonary Surfactants; D011804:Quinolines; D000078304:Tigecycline; D000077726:Doripenem; D008911:Minocycline; D000069349:Linezolid; D017576:Daptomycin; D000077266:Moxifloxacin; D003091:Colistin