title: Synthesis and bioassay of a new class of furanyl-1,3,4-oxadiazole derivatives.
abstract: Tyrosinase enzyme is a monophenol monoxygenase enzyme, which plays an important role in human as a rate limiting step enzyme for different specific metabolic pathways, as well as its useful application in industry and agriculture. So this study was carried out to test the effect of newly prepared compounds containing 1,3,4-oxadiazoles with different substituted groups on tyrosinase enzyme activity, hoping to use them in the treatment of some diseases arising from tyrosinase activity disorders such as Parkinson's disease, schizophrenia, autism, attention deficit, hyperactivity disorder, and cancer.
authors.affiliation: Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. mohamed.elsadik@alexu.edu.eg
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: El Sadek
authors.forename: Seham Y
authors.initials: SY
authors.lastname: Hassan
authors.forename: Huda E
authors.initials: HE
authors.lastname: Abdelwahab
authors.forename: Galila A
authors.initials: GA
authors.lastname: Yacout
mesh_terms: D001681:Biological Assay; D005663:Furans / Q000737:chemistry*; D006801:Humans; D014442:Monophenol Monooxygenase / Q000235:genetics / Q000378:metabolism*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D005663:Furans; D010069:Oxadiazoles; D014442:Monophenol Monooxygenase