title: Acaricidal activities of β-caryophyllene oxide and structural analogues derived from Psidium cattleianum oil against house dust mites.
abstract: BACKGROUND
  This study was to evaluate the acaricidal activities of an active compound isolated from Psidium cattleianum and structural analogues against Dermatophagoides farinae and D. pteronyssinus. β-Caryophyllene oxide was isolated using chromatographic techniques.
  
  
  RESULTS
  Based on the 50% lethal concentration (LD50) values against D. farinae using the fumigant method, β-caryophyllene oxide (1.36 µg cm(-2)) was ∼ 7.52 times more toxic than benzyl benzoate (10.23 µg cm(-2)), followed by α-caryophyllene (1.75 µg cm(-2)) and β-caryophyllene (3.13 µg cm(-2)). Against D. pteronyssinus, β-caryophyllene oxide (1.38 µg cm(-2)) was ∼ 7.22 times more toxic than benzyl benzoate (9.96 µg cm(-2)), followed by α-caryophyllene (1.71 µg cm(-2)) and β-caryophyllene (3.58 µg cm(-2)). In the contact toxicity method against D. farinae, β-caryophyllene oxide (0.44 µg cm(-2)) was ∼ 17.27 times more active than benzyl benzoate (7.60 µg cm(-2)), followed by α-caryophyllene (0.67 µg cm(-2)) and β-caryophyllene (0.91 µg cm(-2)). Against D. pteronyssinus, β-caryophyllene oxide (0.47 µg cm(-2)) was ∼ 13.06 times more effective than benzyl benzoate (6.14 µg cm(-2)), followed by α-caryophyllene (1.71 µg cm(-2)) and β-caryophyllene (3.58 µg cm(-2)).
  
  
  CONCLUSIONS
  β-Caryophyllene oxide and structural analogues have potential for development as preventive agents for the control of house dust mites.
authors.affiliation: Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju, 561-756, South Korea.
authors.forename: Min-Seok
authors.initials: MS
authors.lastname: Oh
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Yang
authors.forename: Min-Gi
authors.initials: MG
authors.lastname: Kim
authors.forename: Hoi-Seon
authors.initials: HS
authors.lastname: Lee
mesh_terms: D056810:Acaricides / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D040001:Dermatophagoides farinae / Q000187:drug effects*; D040002:Dermatophagoides pteronyssinus / Q000187:drug effects*; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D031647:Psidium / Q000737:chemistry*
chemical_list: D056810:Acaricides; D009822:Oils, Volatile; D010936:Plant Extracts
keywords: Dermatophagoides farinae; Dermatophagoides pteronyssinus; Psidium cattleianum; house dust mites; β-caryophyllene oxide