title: Synthesis of a novel water-soluble zinc phthalocyanine and its CT DNA-damaging studies.
abstract: A novel 3-(4-methoxybenzylamino) propanoic acid substituted water-soluble zinc phthalocyanine (CNPcZn) was synthesized. The interaction between CNPcZn with calf thymus DNA (CT DNA) was studied using spectroscopic methods. The studies indicated that CNPcZn has strong affinity to CT DNA, and furthermore, CNZnPc showed excellent photodamaging activity to CT DNA. Above results indicated that such CNPcZn has great potential to be used as an effective photosensitizer in the field of photodynamic therapy.
authors.affiliation: College of Chemistry and Materials Science, Key Laboratory of Applied Photochemistry, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210046, PR China.
authors.forename: Tianhui
authors.initials: T
authors.lastname: Wang
authors.forename: Ao
authors.initials: A
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Shan
authors.initials: S
authors.lastname: Lu
authors.forename: Weiwei
authors.initials: W
authors.lastname: Jiang
authors.forename: Yun
authors.initials: Y
authors.lastname: Lin
authors.forename: Jiahong
authors.initials: J
authors.lastname: Zhou
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wei
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000737:chemistry; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D004996:Ethidium / Q000378:metabolism; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D054833:Isoindoles; D007700:Kinetics; D008027:Light; D009691:Nucleic Acid Denaturation / Q000187:drug effects / Q000528:radiation effects; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011422:Propionates / Q000737:chemistry; D012995:Solubility; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*; D017967:Zinc Compounds
chemical_list: D000873:Anthracenes; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D011422:Propionates; D012996:Solutions; D017967:Zinc Compounds; C110869:anthracene-9,10-dipropionic acid; D014867:Water; C052159:Zn(II)-phthalocyanine; D004247:DNA; C427203:calf thymus DNA; D004996:Ethidium
keywords: CT DNA; Photodynamic therapy; Phthalocyanine; Singlet oxygen; Water-soluble