title: Leclercia adecarboxylata and catheter-related bacteraemia: review of the literature and outcome with regard to catheters and patients.
abstract: Infection is a common complication in patients carrying a central venous catheter (CVC) and is associated with increased morbidity and mortality. Leclercia adecarboxylata is an unusual but emerging pathogen in healthy and immunocompromised patients. We report a case of L. adecarboxylata bacteraemia in a patient with a haemodialysis tunnelled CVC. In accordance with the susceptibility to the tested antimicrobials, a long-course treatment with intravenous gentamicin plus amoxicillin-clavulanic acid and gentamicin-lock therapy was adopted. The patient had a full recovery and the catheter was not removed. We also performed a systematic PubMed/Medline and Scopus review of peer-reviewed English papers on L. adecarboxylata infections, focusing on bacteraemia in patients with different types of CVCs. Moreover, we suggest a treatment algorithm to preserve the patient and maintain the CVC.
authors.affiliation: Nephrology and Dialysis Unit, University Hospital 'Maggiore della Carità', Novara, Italy.
authors.forename: Andreana
authors.initials: A
authors.lastname: De Mauri
authors.affiliation: Nephrology and Dialysis Unit, University Hospital 'Maggiore della Carità', Novara, Italy.
authors.forename: Doriana
authors.initials: D
authors.lastname: Chiarinotti
authors.affiliation: Microbiology and Virology Laboratory, University Hospital 'Maggiore della Carità', Novara, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Andreoni
authors.affiliation: Microbiology and Virology Laboratory, University Hospital 'Maggiore della Carità', Novara, Italy.
authors.forename: Gian Lorenzo
authors.initials: GL
authors.lastname: Molinari
authors.affiliation: Nephrology and Dialysis Unit, University Hospital 'Maggiore della Carità', Novara, Italy.
authors.forename: Novella
authors.initials: N
authors.lastname: Conti
authors.affiliation: Nephrology and Dialysis Unit, University Hospital 'Maggiore della Carità', Novara, Italy.
authors.forename: Martino
authors.initials: M
authors.lastname: De Leo
mesh_terms: D061605:Administration, Intravenous; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D055499:Catheter-Related Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects; D021821:Communicable Diseases, Emerging / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D004755:Enterobacteriaceae / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008297:Male; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents