title: IL-10, TNF-α & IFN-γ: potential early biomarkers for preeclampsia.
abstract: The present study was designed to evaluate levels of IL4, IL10, TNF-α & IFN-γ at early second trimester and 24h from delivery to assess potential correlation of cytokine variation with preeclampsia. A total of 176 consecutive healthy, normotensive primigravidas with uncomplicated singleton pregnancies were recruited at 14-18weeks of gestation. Serum cytokine levels were estimated at recruitment and 24h from delivery. In present study, 14(7.95%) women developed preeclampsia. Levels of IL-10, TNF-α and IFN-γ (Mean±SE) at recruitment were statistically significantly lower in preeclamptic group (39.21±9.46pg/mL, 73.57±13.37pg/mL and 0.70±0.20pg/mL, respectively) than non-preeclamptic group (86.02±4.55pg/mL, 601.37±63.54pg/mL and 1.67±0.08pg/mL, respectively) (p<0.05). In preeclamptic group, IL-4 and TNF-α levels (Mean±SE) were significantly higher 24h from delivery (5.35±0.95pg/mL and 381.21±43.28pg/mL, respectively) than at recruitment (2.39±0.71pg/mL and 73.57±13.37pg/mL) (p=0.019 and 0.0001, respectively) while IL-10 and IFN-γ levels decreased after delivery but the change was not statistically significant. Therefore, the levels of IL-10, TNF-α and IFN-γ between 14 and 18weeks of gestation may act as potential early biomarkers in the diagnosis of preeclampsia.
authors.affiliation: Department of Obstetrics & Gynaecology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi 110 002, India. ashkumar@eth.net
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.forename: Nargis
authors.initials: N
authors.lastname: Begum
authors.forename: Sudha
authors.initials: S
authors.lastname: Prasad
authors.forename: Sarita
authors.initials: S
authors.lastname: Agarwal
authors.forename: Shashi
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508609:IL10 protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma
keywords: Cytokines; IFN-γ; IL-10; Preeclampsia; Pregnancy