title: The anti-obesity effects of the dietary combination of fermented red ginseng with levan in high fat diet mouse model.
abstract: In this study, to evaluate the anti-obesity effects of fermented red ginseng (FG), levan (L), and their combination (FGL), we investigated their effects on the weights of body, liver and white adipose tissue, lipid profiles, and biomarkers for insulin resistance in high fat diet (HFD)-induced obese C57BL/6J male mice. Furthermore, the levels of leptin in the serum were measured. FG (150 mg/kg/d), L (100 mg/kg/d), and FGL (150 mg/kg/d of FG plus 100 mg/kg/d of L) were administered orally to mice daily for 11 weeks. After 11 weeks feeding, FGL showed significantly lower body weight and fat mass with decreasing food efficiency ratio than the HFD control mice. In addition, the FGL group was significantly lower in the levels of total cholesterol and fasting blood glucose and score of the homeostatic model assessment of insulin resistance. Furthermore, FGL decreased serum leptin levels compared to the HFD control group. Taken together, FGL showed a significant anti-obesity effect in HFD-induced obese mice and prevent insulin and leptin resistance. FGL may be potentially useful for the prevention of obesity.
authors.affiliation: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, 151-742, Korea.
authors.forename: Jin sun
authors.initials: Js
authors.lastname: Oh
authors.forename: Seung Ri
authors.initials: SR
authors.lastname: Lee
authors.forename: Keum Taek
authors.initials: KT
authors.lastname: Hwang
authors.forename: Geun Eog
authors.initials: GE
authors.lastname: Ji
mesh_terms: D052436:Adipose Tissue, White / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000737:chemistry; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D005285:Fermentation; D005630:Fructans / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000188:drug therapy; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D019440:Anti-Obesity Agents; D001786:Blood Glucose; D005630:Fructans; D007328:Insulin; D020738:Leptin; D008055:Lipids; D010936:Plant Extracts; C072599:levan; D002784:Cholesterol
keywords: anti-hyperlipidemia; anti-obesity; fermented ginseng extract; high fat diet mouse model; insulin resistance; levan