title: Pregnancy and perinatal outcomes among women with multiple sclerosis: a retrospective case-controlled study in South Hungary.
abstract: OBJECTIVE
  The aim of this study was to investigate the connections between multiple sclerosis (MS) and fertility, pregnancy.
  
  
  METHODS
  The case histories and pregnancy complications in a sample of 65 treatment-naive pregnant women with MS in the period 1998-2012 were compared with an age-matched case-controlled analysis. Comparisons were made between primigravidas and multigravidas subjects.
  
  
  RESULTS
  Our results revealed a higher rate of miscarriage (18.46%) in the first trimester in women with MS, and intrauterine death (7.69%) in the third trimester, as compared with women without MS (p < 0.001 and p = 0.035).
  
  
  CONCLUSIONS
  These findings suggest that, the risk of miscarriages and intrauterine death may be disease-related not drug-related feature. Further studies are needed to determine to possible associated factors of miscarriages.
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of General Medicine .
authors.forename: Melinda
authors.initials: M
authors.lastname: Vanya
authors.forename: Tibor
authors.initials: T
authors.lastname: Nyari
authors.forename: Krisztina
authors.initials: K
authors.lastname: Bencsik
authors.forename: György
authors.initials: G
authors.lastname: Bartfai
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D016022:Case-Control Studies; D000013:Congenital Abnormalities / Q000453:epidemiology; D005260:Female; D005313:Fetal Death; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D009103:Multiple Sclerosis / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult