title: Imaging of mandible invasion by oral squamous cell carcinoma using computed tomography, cone-beam computed tomography and bone scintigraphy with SPECT.
abstract: OBJECTIVE
  The objective of this paper is to evaluate the predictability of preoperative tumour bone invasion of the mandible by squamous cell carcinoma of the oral cavity using CT, cone-beam CT and bone scintigraphy with SPECT.
  
  
  METHODS
  Eighty-four patients who had received CT, SPECT or cone-beam computed tomography (CBCT), as well as a further 48 patients who undergone all these investigations for preoperative evaluation of bone invasion were included in the study. A case-control analysis and the receiver operating characteristics were performed. Histological results of bone specimens served as the gold standard for assessment of bone invasion.
  
  
  RESULTS
  CBCT and SPECT showed a comparable sensitivity for bone invasion (93 % [CI 0.816-0.972] and 96 % [CI 0.867-0.990], respectively) which was significantly higher than that of CT (63 % [CI 0.488-0.752]). Further, CBCT obtained higher specificity than SPECT (62 % [CI 0.478-0.743] and 48 % [CI 0.342-0.614], respectively), whereas CT showed the best specificity among the investigation methods (81 % [CI 0.677-0.896]).
  
  
  CONCLUSIONS
  CT scan provides by its high specificity and positive predictive value a precise imaging technique for clinical routine. However, CBCT shows a much higher sensitivity for cortical bone invasion and a better negative predictive value. With a significantly lower exposure dose it can rule out this invasion effectively and prevent overtreatment.
  
  
  CONCLUSIONS
  Considering the high-resolution images delivered by CBCT along with minimized artefacts in the mandible it provides an alternative imaging technique, which could be combined and accomplished with another soft-tissue imaging modality like MRI to obtain optimal hard and soft-tissue visualisation in patients with squamous cell carcinoma of the oral cavity.
authors.affiliation: Department of Maxillofacial Surgery, University Hospital of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany, samer.hakim@mkg-chir.mu-luebeck.de.
authors.forename: Samer G
authors.initials: SG
authors.lastname: Hakim
authors.forename: Henning
authors.initials: H
authors.lastname: Wieker
authors.forename: Thomas
authors.initials: T
authors.lastname: Trenkle
authors.forename: Peter
authors.initials: P
authors.lastname: Sieg
authors.forename: Jens
authors.initials: J
authors.lastname: Konitzer
authors.forename: Konstanze
authors.initials: K
authors.lastname: Holl-Ulrich
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Jacobsen
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D054893:Cone-Beam Computed Tomography; D006801:Humans; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology*; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D009361:Neoplasm Invasiveness; D015899:Tomography, Emission-Computed, Single-Photon