title: TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation.
abstract: Single nucleotide polymorphisms (SNPs) have been associated with an increased incidence of invasive aspergillosis (IA) after allogeneic stem cell transplantation (allo-SCT). We analyzed 41 patients with proven/probable IA after allo-SCT for an association of SNPs, within the TLR2, TLR4, TLR5, TLR9, and NOD2/CARD15 genes, with susceptibility to IA. The control group consisted of 130 patients who had allo-SCT but did not develop IA. While no association was found for donor SNPs and the recipients' risk of IA, analysis of recipient SNPs showed a significant association between the presence of recipient TLR5-Stop SNP (1174C> T) and the incidence of IA (P = 0.004). Multivariate analysis demonstrated that the recipient TLR5-Stop SNP appeared as an independent risk factor for IA after allo-SCT. Our study suggests that TLR5 is involved in host defense against Aspergillus fumigatus, and that the recipient TLR5-Stop SNP represents a risk factor for the development of IA after allo-SCT.
authors.affiliation: * Abteilung Hämatologie/Onkologie, Universitätsklinikum Regensburg , Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Grube
authors.forename: Juergen
authors.initials: J
authors.lastname: Loeffler
authors.forename: Markus
authors.initials: M
authors.lastname: Mezger
authors.forename: Bernd
authors.initials: B
authors.lastname: Krüger
authors.forename: Bernd
authors.initials: B
authors.lastname: Echtenacher
authors.forename: Petra
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Matthias
authors.initials: M
authors.lastname: Edinger
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.forename: Reinhard
authors.initials: R
authors.lastname: Andreesen
authors.forename: Ernst
authors.initials: E
authors.lastname: Holler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001228:Aspergillosis / Q000453:epidemiology / Q000235:genetics*; D018389:Codon, Nonsense; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D051198:Toll-Like Receptor 5 / Q000235:genetics*; D014184:Transplantation, Homologous / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D018389:Codon, Nonsense; C495346:TLR5 protein, human; D051198:Toll-Like Receptor 5