title: Expression analysis of a family of developmentally-regulated cytosolic sulfotransferases (SULTs) in Drosophila.
abstract: We have compared the amino acid sequence of all four cytosolic sulfotransferases (SULTs) in Drosophila and analyzed their spatial expression patterns during development. Three out of four SULTs show distinct expression activity during embryogenesis, while the 4th SULT shows expression only post-embryonically. st1, st3 and st4 are expressed in non-overlapping expression domains mainly confined to organs of the alimentary canal such as esophagus, malphigian tubules, hindgut, as well as in the tracheal system. All these organs are surrounded by the hemolymph suggesting that Drosophila SULTs exert their function in detoxification of substances upon influx from the hemolymph.
authors.affiliation: Department of Experimental Medical Sciences, Lund University, Lund, Sweden.
authors.forename: Khalid
authors.initials: K
authors.lastname: Fahmy
authors.forename: Stefan
authors.initials: S
authors.lastname: Baumgartner
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D018076:DNA, Complementary / Q000378:metabolism; D004331:Drosophila melanogaster / Q000201:enzymology* / Q000235:genetics; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D006458:Hemolymph / Q000201:enzymology; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D015238:Sulfotransferases / Q000235:genetics / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D018076:DNA, Complementary; D015238:Sulfotransferases