title: Split of chiral degeneracy in mechanical and structural properties of oligopeptide-polysaccharide biomaterials.
abstract: Enantiomeric biomaterials which are mirror images of each other are characterized by chiral degeneracy--identical structural characteristics and bulk material properties. The addition of another chiral component, D-polysaccharide, has been shown to split such degeneracy and result in two distinct biomaterials. Dynamic oscillatory rheometry and small-angle X-ray scattering demonstrate that the natural biochirality combination of L-peptides and D-polysaccharides assembles faster, has higher elastic moduli (G'), and is structurally more beneficial as opposed to the alternative D-peptide and D-polysaccharide combination. Chemical modifications of the OH-groups in α-D-glucose units in D-polysaccharides weaken such splitting of chiral degeneracy. These findings form a basis to design novel biomaterials and provide additional insight on why proteins and polysaccharides have oppoiste chirality in the biological world.
authors.affiliation: Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
authors.forename: Marc B
authors.initials: MB
authors.lastname: Taraban
authors.forename: Laura L
authors.initials: LL
authors.lastname: Hyland
authors.forename: Y Bruce
authors.initials: YB
authors.lastname: Yu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002809:Chondroitin Sulfates / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D055119:Elastic Modulus; D006003:Glycogen / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D008422:Materials Testing; D008956:Models, Chemical; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D053838:Scattering, Small Angle; D013237:Stereoisomerism; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D003505:Cyclodextrins; D020100:Hydrogels; D009842:Oligopeptides; D002482:Cellulose; D006003:Glycogen; D002809:Chondroitin Sulfates; C008079:hydroxypropylcellulose