title: Dioxygen-triggered oxidative radical reaction: direct aerobic difunctionalization of terminal alkynes toward β-keto sulfones.
abstract: An unprecedented dioxygen-triggered oxidative radical process was explored using dioxygen as the solely terminal oxidant, realizing aerobic oxidaitve difunctionalization of terminal alkynes toward β-keto sulfones with high selectivity. Operando IR experiments revealed that pyridine not only acts as a base to successfully surpress ATRA (atom transfer radical addition) process, but also plays a vital role in reducing the activity of sulfinic acids.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Lu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Ganglu
authors.initials: G
authors.lastname: Zhao
authors.forename: Yue
authors.initials: Y
authors.lastname: Qi
authors.forename: Huamin
authors.initials: H
authors.lastname: Wang
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007659:Ketones; D016877:Oxidants; D011725:Pyridines; D013450:Sulfones; C023666:pyridine; D010100:Oxygen