title: Bisphosphonate-related osteonecrosis of the jaws and its relevance to children--a review.
abstract: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) has been detailed extensively in adults, but to date, there have been no similar cases in children. Members of the dental team may treat children prescribed bisphosphonate therapy often for management of osteogenesis imperfecta (OI). There is uncertainty as to how best treat this patient group. This review explores the background of bisphosphonates, indications for their prescription in children, adverse effects with special emphasis on BRONJ, and protocols available to guide dental management.
authors.affiliation: Department of Oral Medicine, Eastman Dental Hospital and Eastman Dental Institute, UCLHT UCL, London, UK.
authors.forename: Joanna
authors.initials: J
authors.lastname: Christou
authors.forename: Adele R
authors.initials: AR
authors.lastname: Johnson
authors.forename: Tim A
authors.initials: TA
authors.lastname: Hodgson
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D002648:Child; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans; D010013:Osteogenesis Imperfecta / Q000188:drug therapy*; D012307:Risk Factors
chemical_list: D004164:Diphosphonates