title: Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection.
abstract: Variations in genes involved in the immune response pathways may influence the interaction between viruses (such as Human T-lymphotropic virus, HTLV-1) and the host. The mannose binding lectin (MBL) and its associated serine protease type 2 (MASP-2) promote the activation of the lectin pathway of the complement system. As the interaction of complement system with HTLV-1 is not well understood, the MBL2 promoter/exon 1 polymorphisms and a MASP2 missense polymorphism were examined in a Northeast Brazilian population, looking for a possible relationship between these variations and the susceptibility to HTLV-1 infection. The present study describes an association between a polymorphism in the MASP2 gene and susceptibility to HTLV-1 infection, and provides further evidence of an association between the MBL2 gene and HTLV-1 infection. These findings suggest an important role of the complement system activation, via the lectin pathway, in the susceptibility to HTLV-1 infection.
authors.affiliation: Department of Genetics, Federal University of Pernambuco (UFPE), Recife, PE, Brazil.
authors.forename: Antonio Victor Campos
authors.initials: AV
authors.lastname: Coelho
authors.forename: Lucas André Cavalcanti
authors.initials: LA
authors.lastname: Brandão
authors.forename: Rafael Lima
authors.initials: RL
authors.lastname: Guimarães
authors.forename: Paula
authors.initials: P
authors.lastname: Loureiro
authors.forename: José Luiz
authors.initials: JL
authors.lastname: de Lima Filho
authors.forename: Luiz Cláudio Arraes
authors.initials: LC
authors.lastname: de Alencar
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
authors.forename: Ludovica
authors.initials: L
authors.lastname: Segat
mesh_terms: D000328:Adult; D001938:Brazil; D003165:Complement System Proteins / Q000276:immunology; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D015490:HTLV-I Infections / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D050606:Mannose-Binding Protein-Associated Serine Proteases / Q000235:genetics*; D008875:Middle Aged; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D055815:Young Adult
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; D003165:Complement System Proteins; C105296:MASP2 protein, human; D050606:Mannose-Binding Protein-Associated Serine Proteases
keywords: HTLV; MASP2; MBL2; SNPs; innate immunity