title: [Molecular mechanisms of leupaxin involved in prostate carcinoma metastasis].
abstract: Leupaxin (LPXN) is a new member of the Paxillin superfamily, mainly located in focal adhesion plaques, involved in the transduction of multiple signaling pathways, and regulating the proliferation, adhesion and migration of tumor cells. In prostate cancer cells, LPXN is not only involved in the integrin signaling transduction pathway, regulating the proliferation, adhesion and migration of prostate cancer cells, but is also a new androgen receptor (AR) coactivator, regulating the transcription of nuclear AR effect genes, participating in AR signal transduction, and regulating the differentiation and invasion of prostate cancer cells. This review focuses on the molecular structure, special roles and molecular mechanisms of LPXN involved in prostatic carcinoma metastasis.
authors.affiliation: The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, China. zhugh0601@163.com
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Zhu
authors.forename: Hai-Ping
authors.initials: HP
authors.lastname: Dai
authors.forename: Qun
authors.initials: Q
authors.lastname: Shen
mesh_terms: D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D011944:Receptors, Androgen / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015815:Cell Adhesion Molecules; C112251:LPXN protein, human; D010750:Phosphoproteins; D011944:Receptors, Androgen