title: Synthesis of thiosemicarbazones derived from N-(4-hippuric acid)thiosemicarbazide and different carbonyl compounds as antimicrobial agents.
abstract: New series of thiosemicarbazone derivatives incorporating a hippuric acid moiety have been synthesized through the reaction of N-(4-hippuric acid)thiosemicarbazide with various carbonyl compounds such as aldehydes, ketones and cyclic ketones. The synthesized compounds were tested against bacterial and fungal strains. Most of compounds, such as 2-(4-(2-(4-fluorobenzylidene)hydrazinecarbothioamido)benzamido)acetic acid showed significant antibacterial and antifungal activities. These compounds comprise a new class of promising broad-spectrum antibacterial and antifungal agents.
authors.affiliation: Applied Organic Chemistry Department, National Research Centre, Cairo, Egypt.
authors.forename: Marwa A M Sh
authors.initials: MA
authors.lastname: El-Sharief
authors.forename: Samir Y
authors.initials: SY
authors.lastname: Abbas
authors.forename: Khairy A M
authors.initials: KA
authors.lastname: El-Bayouki
authors.forename: Eman W
authors.initials: EW
authors.lastname: El-Gammal
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects; D006626:Hippurates / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012663:Semicarbazides / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006626:Hippurates; C587512:N-(4-hippuric acid)thiosemicarbazide; D012663:Semicarbazides; D013882:Thiosemicarbazones
keywords: Antimicrobial activity; Carbonyl compounds; Hippuric acid; Thiosemicarbazide; Thiosemicarbazones