title: Influence of drug encapsulation within mixed micelles on the excited state dynamics and accessibility to ionic quenchers.
abstract: Photophysical techniques, specifically time-resolved fluorescence and laser flash photolysis, have proven to be noninvasive, straightforward, and valuable tools to demonstrate how drug encapsulation into biomimetic mixed micelles (MM) influences the dynamics of excited states and their accessibility to ionic quenchers. This concept has been illustrated by choosing a set of currently administered drugs containing a common naphthalene chromophore, namely, (S)-naproxen and its methyl ester, (R)-cinacalcet and (S)-propranolol. A remarkable increase of their triplet lifetimes is noticed when experiments are performed in MM, indicating efficient entrapment of the drugs in these supramolecular entities. Furthermore, a decrease of 1 order of magnitude in the quenching rate constant of the singlet and triplet excited states (by iodide or nitrite, respectively) is observed upon encapsulation into MM. This approach can in principle be extended to other microenvironments capable of incorporating photoactive compounds.
authors.affiliation: Instituto Universitario Mixto de Tecnología Química (UPV-CSIC), Universitat Politècnica de València, Avenida de los Naranjos s/n, 46022 Valencia, Spain.
authors.forename: Edurne
authors.initials: E
authors.lastname: Nuin
authors.forename: Miguel
authors.initials: M
authors.lastname: Gomez-Mendoza
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Marin
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Andreu
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Miranda
mesh_terms: D002214:Capsules / Q000737:chemistry*; D002784:Cholesterol / Q000737:chemistry; D019826:Cholic Acid / Q000737:chemistry; D016503:Drug Delivery Systems; D007477:Ions; D054709:Lecithins / Q000737:chemistry; D008823:Micelles; D055668:Photochemical Processes
chemical_list: D002214:Capsules; D007477:Ions; D054709:Lecithins; D008823:Micelles; D002784:Cholesterol; D019826:Cholic Acid