title: Acidic lactate sequentially induced lymphogenesis, phlebogenesis, and arteriogenesis (ALPHA) hypothesis: Lactate-triggered glycolytic vasculogenesis that occurs in normoxia or hypoxia and complements the traditional concept of hypoxia-based vasculogenesis.
abstract: Our hypothesis, ALPHA (Acidic Lactate sequentially induced Lymphogenesis, PHlebogenesis, and Arteriogenesis) proposes that lactate triggers vasculogenesis to manage lactate levels and complements the traditional vasculogenesis hypothesis. The teleologic basis for glycolytic vasculogenesis is primariy to produce drainage vessels, initially lymphatics but subsequently veins.
authors.affiliation: Department of Radiology, Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA. john.haaga@uhhospitals.org
authors.forename: John R
authors.initials: JR
authors.lastname: Haaga
authors.forename: Rebecca
authors.initials: R
authors.lastname: Haaga
mesh_terms: D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D006019:Glycolysis; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology; D019344:Lactic Acid / Q000378:metabolism*; D042583:Lymphangiogenesis / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000209:etiology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D019344:Lactic Acid