title: Topical anti-inflammatory potential of standardized pomegranate rind extract and ellagic acid in contact dermatitis.
abstract: The present study evaluated the topical anti-inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against a mouse model of contact dermatitis. In the phenol-induced mouse ear edema, topical application of SPRE (5, 2.5, and 1 mg/ear) and EA (0.65, 0.325, and 0.13 mg/ear, equivalent to its content in SPRE) dose-dependently reduced the ear edema with the maximal inhibition of 79.12% and 73.63%, respectively. Triamcinolone (0.1 mg/ear) and diclofenac (1 mg/ear) as reference drugs inhibited the edema by 73.63% and 37.91%. Myeloperoxidase (MPO) activity in the mouse ear was also decreased by SPRE and EA up to 69.68% and 68.79%, respectively. Triamcinolone and diclofenac decreased the MPO activity by 76.66% and 80.14% similarly. The results indicated that topical application of SPRE and EA is promising for use in the treatment of inflammatory skin disorders.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
authors.forename: Jiao
authors.initials: J
authors.lastname: Mo
authors.forename: Pharkphoom
authors.initials: P
authors.lastname: Panichayupakaranant
authors.forename: Nattha
authors.initials: N
authors.lastname: Kaewnopparat
authors.forename: Sarunyoo
authors.initials: S
authors.lastname: Songkro
authors.forename: Wantana
authors.initials: W
authors.lastname: Reanmongkol
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000188:drug therapy*; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004610:Ellagic Acid / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D029561:Lythraceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009195:Peroxidase / Q000378:metabolism; D010636:Phenols / Q000009:adverse effects; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D010636:Phenols; D010936:Plant Extracts; D004610:Ellagic Acid; D009195:Peroxidase
keywords: Punica granatum; contact dermatitis; ellagic acid; inflammation; topical application