title: Assessment of salivary gland function in patients after successful kidney transplantation using (99m)Tc-pertechnetate salivary gland scintigraphy.
abstract: Chronic renal failure and its treatment can induce oral health problems and salivary glands dysfunction. The purpose of this study was to assess salivary glands function in patients with kidney transplantation using technetium-99m pertechnetate ((99m)Tc-P) salivary glands scintigraphy. We prospectively studied 34 patients with kidney transplantation (30 males and 4 females,mean age 39.76±11.6 years) and 28 healthy controls (12 males and 16 females, mean age 36.1±9.5 years). Salivary gland scintigraphy was performed nearly 4.4±2.9 years after successful kidney transplantation. Dynamic salivary glands scintigraphy was performed during 25min after the intravenous administration of 185MBq of (99m)Tc-P. Time-activity curves and glands functional parameters were calculated for the parotid and submandibular salivary glands: uptake ratio, maximum accumulation of the radionuclide, and excretion fraction. Statistical analysis of the functional parameters showed no significant differences between patients with kidney transplantation and healthy controls (P>0.05). In conclusion, this study showed that using (99m)Tc-P salivary gland scintigraphy, salivary glands function of patients with successful kidney transplantation do not differ statistically from those in healthy controls.
authors.affiliation: Department of Nuclear Medicine, Ataturk University, Erzurum, Turkey. e.orsal@yahoo.com.tr
authors.forename: Ebru
authors.initials: E
authors.lastname: Orsal
authors.forename: Bedri
authors.initials: B
authors.lastname: Seven
authors.forename: Mustafa
authors.initials: M
authors.lastname: Keles
authors.forename: Arif Kursad
authors.initials: AK
authors.lastname: Ayan
authors.forename: Erdem
authors.initials: E
authors.lastname: Cankaya
authors.forename: Ozalkan
authors.initials: O
authors.lastname: Ozkan
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000000981:diagnostic imaging*; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012466:Salivary Gland Diseases / Q000000981:diagnostic imaging* / Q000209:etiology*; D012469:Salivary Glands / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D013670:Sodium Pertechnetate Tc 99m; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m