title: Six weeks of voluntary exercise don't protect C57BL/6 mice against neurotoxicity of MPTP and MPP(+).
abstract: Exercise improves the central nervous system (CNS) functions and is widely recommended for neurological patients with, e.g., Alzheimer's and Parkinson's disease (PD). However, exercise-induced neuroprotection is an open discussion. Here, the intranasal administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 65 mg/kg) caused death of dopaminergic neurons in the substantia nigra pars compacta and depletion of dopamine in the striatum of C57BL/6 mice. 1-Methyl-4-phenylpyridinium, the active metabolite of MPTP, also inhibited complex-I activity of mitochondria isolated from the CNS of mice. However, 6 weeks of exercise on voluntary running wheels did not protect against nigrostriatal neurodegeneration or mitochondrial inhibition, suggesting that benefits of exercise for PD may not be associated with neuroprotection. The literature presents other candidates, such as neurotrophins or increased antioxidant defenses.
authors.affiliation: Departamento de Bioquímica, Centro de Ciências Biológicas (CCB), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, 88040-900, Brazil, aderbal.aguiar@ufsc.br.
authors.forename: Aderbal S
authors.initials: AS
authors.lastname: Aguiar
authors.forename: Fabrine Sales Massafera
authors.initials: FS
authors.lastname: Tristão
authors.forename: Majid
authors.initials: M
authors.lastname: Amar
authors.forename: Caroline
authors.initials: C
authors.lastname: Chevarin
authors.forename: Viviane
authors.initials: V
authors.lastname: Glaser
authors.forename: Roberta
authors.initials: R
authors.lastname: de Paula Martins
authors.forename: Eduardo Luiz Gasnhar
authors.initials: EL
authors.lastname: Moreira
authors.forename: Raymond
authors.initials: R
authors.lastname: Mongeau
authors.forename: Laurence
authors.initials: L
authors.lastname: Lanfumey
authors.forename: Rita
authors.initials: R
authors.lastname: Raisman-Vozari
authors.forename: Alexandra
authors.initials: A
authors.lastname: Latini
authors.forename: Rui D S
authors.initials: RD
authors.lastname: Prediger
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage; D015655:1-Methyl-4-phenylpyridinium / Q000008:administration & dosage; D000281:Administration, Intranasal; D000818:Animals; D003342:Corpus Striatum / Q000737:chemistry / Q000187:drug effects; D004298:Dopamine / Q000032:analysis; D050483:Dopamine Plasma Membrane Transport Proteins / Q000032:analysis; D020267:MPTP Poisoning / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D010805:Physical Conditioning, Animal; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015655:1-Methyl-4-phenylpyridinium; D004298:Dopamine