title: Self-assembled graphene-dextran nanohybrid for killing drug-resistant cancer cells.
abstract: A nanohybrid based on nanoscale graphene oxide (NGO) and dextran has been designed and employed for effectively killing drug-resistant MCF-7/ADR cells. This graphene-based nanohybrid was readily prepared through π-π interaction of NGO and hematin-terminated dextran (HDex), being denoted as NGO-HDex. It revealed an improved stability in physiological conditions as compared to native NGO. Besides, NGO-HDex could efficiently load doxorubicin (DOX), an anticancer drug, with drug loading capacity of 3.4 mg/mg NGO and liberate the drug with a pH-dependent profile. Cell viability assay indicated that the NGO-HDex displayed lower cytotoxicity against MCF-7/ADR cells as compared to native NGO. DOX-loaded NGO-HDex, however, revealed more efficient killing effect in the cells than free DOX because the nanohybrid caused a higher amount of DOX accumulated in the cells. The results of this study highlight that the NGO-HDex has high potential for killing drug-resistant cancer cells.
authors.affiliation: Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, China. r.jin@shu.edu.cn
authors.forename: Rong
authors.initials: R
authors.lastname: Jin
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Ji
authors.forename: Yixin
authors.initials: Y
authors.lastname: Yang
authors.forename: Haifang
authors.initials: H
authors.lastname: Wang
authors.forename: Aoneng
authors.initials: A
authors.lastname: Cao
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D002470:Cell Survival; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003911:Dextrans / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006108:Graphite / Q000737:chemistry*; D006427:Hemin / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D053761:Nanocomposites / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D018384:Oxidative Stress; D010087:Oxides / Q000737:chemistry; D010316:Particle Size; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D003911:Dextrans; D004337:Drug Carriers; D010087:Oxides; D006427:Hemin; D006108:Graphite; D004317:Doxorubicin