title: Cardiac amyloidosis secondary to multiple myeloma.
abstract: Amyloidosis is a multisystemic disease caused by extracellular deposition of pathologic beta fibrillar proteins in multiple organs. Deposited fibrils can be either innunoglobulin light chanis or amyloid-A protein. The incidence of anyloidosis derived from anyloid-A protein, usually associated to an underlying disease, has been dimisishing over the decades in the United States producing clinical evidence of cardiac involvement in less than 5% of all cases. The extent of cardiac involvement is the determining prognostic factor. Early diagnosis and therapy aimed at the underlying disease may halt progression of cardiac dysfuction and improve prognosis. We report a case of a 63-year-old man who was diagnosed with cardiac amyloidosis secondary to multiple myeloma.
authors.affiliation: Section of Cardiology, Department of Medicine, School of Medicine, University of Puerto Rico Medical Science Campus, San Juan, Puerto Rico. frankie_parrilla@yahoo.com
authors.forename: Francisco
authors.initials: F
authors.lastname: Parrilla
authors.forename: Rafael E
authors.initials: RE
authors.lastname: Calderon
authors.forename: Rafael
authors.initials: R
authors.lastname: Figueroa
authors.forename: Carmen
authors.initials: C
authors.lastname: Gurrea
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology*; D006331:Heart Diseases / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*