title: Association of serum paraoxonase activity and coronary artery calcification.
abstract: OBJECTIVE
  It has been known that there was a relation between the activities of serum paraoxonase (PON) and the severity of the coronary artery disease. However, little is known about association of coronary artery calcification (CAC) and serum PON activities. The aim of this study is to evaluate the relationship between CAC and serum PON activities.
  
  
  METHODS
  We measure serum PON activities from 122 patients (42 female, mean age = 62±10 years) with angiographically documented CAC (Group I), and 138 patients (54 female, mean age = 60±10 years) without CAC (Group II). Coronary calcification was detected with fluoroscopy before coronary angiography. Serum PON activities were measured by spectrophotometrically method. Patient characteristics and baseline data were recorded from patient's files.
  
  
  RESULTS
  The triglyceride levels is lower in group I than group II (p = 0.040). Diastolic blood pressure and frequency of diabetes mellitus was higher in the group I than group II (respectively p = 0.012 and p = 0.022). The other clinic and laboratory parameters were similar in two groups (all p > 0.05). The only statistically significant differences between with CAC and without CAC groups in respect to serum PON activities were present (170.6 ± 59.6 vs. 209.6 ± 69.8 U/ml; respectively, p < 0.001). There was a negative correlation between serum PON activities and presence of CAC (p < 0.001).
  
  
  CONCLUSIONS
  These data indicate that the serum PON activities are decreased in patients with CAC. The serum PON activities may play a role in development of the CAC and reduced serum PON activity might represent a biochemical marker of CAC.
authors.affiliation: Department of Cardiology and Department of Cardiovascular Surgery, Medical Faculty of Harran University, Sanliurfa, Turkey. drzekeriyakaya@yahoo.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Kaya
authors.forename: M
authors.initials: M
authors.lastname: Salih Aydin
authors.forename: A
authors.initials: A
authors.lastname: Hazar
authors.forename: E
authors.initials: E
authors.lastname: Can Ata
authors.forename: H
authors.initials: H
authors.lastname: Sezen
authors.forename: A
authors.initials: A
authors.lastname: Yildiz
authors.forename: R
authors.initials: R
authors.lastname: Demirbag
authors.forename: N
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D002114:Calcinosis / Q000097:blood* / Q000000981:diagnostic imaging; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005260:Female; D005471:Fluoroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D043303:Aryldialkylphosphatase