title: Morphoproteomic study of primary pleural angiosarcoma of lymphangioendothelial lineage: a case report.
abstract: An unusual case of bilateral primary pleural angiosarcoma with an immunophenotype of lymphangioendothelial lineage is described. Pleural angiosarcoma is a highly malignant neoplasm for which there is currently no standard of care. A comprehensive immunophenotypic characterization established a lymphangioendothelial lineage. A morphoproteomic analysis was also performed to identify the proteins and corresponding molecular pathways activated in the patient's tumor. The information derived from the morphoproteomic studies provides insight into the biology of the tumor and may be useful in formulating therapeutic alternatives.
authors.affiliation: Department of Pathology, Internal Medicine, University of Texas Medical School at Houston, TX, USA.
authors.forename: Andres
authors.initials: A
authors.lastname: Quesada
authors.forename: Jorge
authors.initials: J
authors.lastname: Quesada
authors.forename: Kamal
authors.initials: K
authors.lastname: Khalil
authors.forename: Emma C
authors.initials: EC
authors.lastname: Ferguson
authors.forename: Robert E
authors.initials: RE
authors.lastname: Brown
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D019070:Cell Lineage; D005260:Female; D006394:Hemangiosarcoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D008202:Lymphangioma / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000378:metabolism / Q000473:pathology*; D040901:Proteomics
chemical_list: D014408:Biomarkers, Tumor
keywords: Morphoproteomics; Pleural Lymphangiosarcoma