title: Synthesis of human growth hormone-releasing hormone via three-fragment serine/threonine ligation (STL).
abstract: The synthesis of human growth hormone-releasing hormone (hGH-RH), by the chemoselective serine/threonine ligations (STLs) of three unprotected peptide fragments, is reported. To allow for the multiple-fragment ligation, we chose the Msz (p-(methylsulfinyl)benzyloxycarbonyl) group, which is compatible with the preparation of peptide salicylaldehyde esters via Fmoc-SPPS and readily removed by reductive acidolysis, to protect the serine and threonine residue at the N-terminus.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Hong Kong, P. R. China.
authors.forename: Yinfeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tianlu
authors.initials: T
authors.lastname: Li
authors.forename: Xuechen
authors.initials: X
authors.lastname: Li
mesh_terms: D013007:Growth Hormone-Releasing Hormone / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D010446:Peptide Fragments / Q000737:chemistry*; D012694:Serine / Q000737:chemistry*; D013912:Threonine / Q000737:chemistry*
chemical_list: D010446:Peptide Fragments; D013912:Threonine; D012694:Serine; D013007:Growth Hormone-Releasing Hormone