title: Primary ovary choriocarcinoma: individual DNA polymorphic analysis as a strategy to confirm diagnosis and treatment.
abstract: Primary choriocarcinoma of the ovary is rare. Furthermore, this tumor can arise from gestational tissue or pure germ cells of the ovary, with the latter resulting in non-gestational choriocarcinoma. While the clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to assay for the presence of paternal DNA. Accordingly, in the present case, a patient with primary choriocarcinoma of the ovary with a non-gestational origin was confirmed by DNA analysis. The patient subsequently exhibited an excellent response to chemotherapy, and following surgery, achieved complete remission. A pathological analysis of surgical specimens further confirmed the absence of tumor.
authors.affiliation: Department of Radiology and Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo.
authors.forename: Pedro
authors.initials: P
authors.lastname: Exman
authors.forename: Tiago Kenji
authors.initials: TK
authors.lastname: Takahashi
authors.forename: Gilka F
authors.initials: GF
authors.lastname: Gattás
authors.forename: Vanessa Dionisio
authors.initials: VD
authors.lastname: Cantagalli
authors.forename: Cristina
authors.initials: C
authors.lastname: Anton
authors.forename: Fernando
authors.initials: F
authors.lastname: Nalesso
authors.forename: Maria Del Pilar Estevez
authors.initials: Mdel P
authors.lastname: Diz
keywords: gestational choriocarcinoma; ovarian choriocarcinoma; pattern analysis