title: Endogenous neuroprotection: hamartin modulates an austere approach to staying alive in a recession.
abstract: Tuberous sclerosis complex 1 (hamartin) is an effective endogenous neuroprotectant. Understanding the endogenous mechanism for neuroprotection mediated by hamartin may afford a novel approach to effective treatment of neurological diseases such as stroke, neurodegenerative diseases, and epilepsy, with possible applications to nonneurological conditions.
authors.affiliation: Acute Stroke Programme, Radcliffe Department of Clinical Medicine, University of Oxford, Oxford, UK.
authors.forename: Gina
authors.initials: G
authors.lastname: Hadley
authors.forename: Gabriele C
authors.initials: GC
authors.lastname: De Luca
authors.forename: Michalis
authors.initials: M
authors.lastname: Papadakis
authors.forename: Alastair M
authors.initials: AM
authors.lastname: Buchan
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000378:metabolism*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D020521:Stroke / Q000378:metabolism*; D000077004:Tuberous Sclerosis Complex 1 Protein; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: C000624650:TSC1 protein, human; D000077004:Tuberous Sclerosis Complex 1 Protein; D025521:Tumor Suppressor Proteins
keywords: acute stroke therapy; hamartin; ischemic stroke; neuroprotection; productive autophagy; treatment