title: Dynamic expression of neurexophilin1 during zebrafish embryonic development.
abstract: Neurexophilin 1 (Nxph1) is a specific endoligand of α-neurexins that is essential for trans-synaptic activation. Here, we report its dynamic expression during development in zebrafish. Our study revealed an early onset of expression of nxph1. RT-PCR on a series of embryonic stages showed that it is maternally deposited, although only readily detectable by whole mount in situ hybridization by 22hpf. During embryogenesis and larval stages, the zygotic transcript is expressed dynamically in various clusters of post-mitotic neurons and in glia in the central nervous system.
authors.affiliation: MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, London SE1 1UL, United Kingdom. Electronic address: swapna.2.thomas@kcl.ac.uk.
authors.forename: Swapna
authors.initials: S
authors.lastname: Thomas-Jinu
authors.forename: Corinne
authors.initials: C
authors.lastname: Houart
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D047108:Embryonic Development; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D007395:Interneurons / Q000378:metabolism; D008969:Molecular Sequence Data; D009457:Neuroglia / Q000378:metabolism; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D009928:Organ Specificity; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D009479:Neuropeptides; D029961:Zebrafish Proteins; C112162:neurexophilin
keywords: Epiphysis; Interneurons; Neurexins; Neurexophilins; Neurons; Synapses; Zebrafish