title: Tissue-engineered oral mucosa for mucosal reconstruction in a pediatric patient with hemifacial microsomia and ankyloglossia.
abstract: Many types of soft tissue grafts have been used for the reconstruction of oral mucosal defects. The best results are achieved with mucosal grafts; however, when large areas must be grafted, sufficient donor tissue is not available. Tissue engineering represents an alternative method to obtain sufficient autologous tissue for reconstructing oral wounds. Herein we present a pediatric patient with hemifacial microsomia and congenital ankyloglossia requiring multiple surgical interventions, and in which an autologous full-thickness tissue-engineered oral mucosa was used for successful oral reconstruction. Our study demonstrates that even under challenging conditions, robust tissue-engineered products, such as the fibrin-based oral mucosa described here, can achieve successful tissue regeneration.
authors.forename: Sara
authors.initials: S
authors.lastname: Llames
authors.forename: Ignacio
authors.initials: I
authors.lastname: Recuero
authors.forename: Ana
authors.initials: A
authors.lastname: Romance
authors.forename: Eva
authors.initials: E
authors.lastname: García
authors.forename: Ignacio
authors.initials: I
authors.lastname: Peña
authors.forename: Alvaro Fernández
authors.initials: AF
authors.lastname: Del Valle
authors.forename: Alvaro
authors.initials: A
authors.lastname: Meana
authors.forename: Fernando
authors.initials: F
authors.lastname: Larcher
authors.forename: Marcela
authors.initials: M
authors.lastname: Del Río
mesh_terms: D000072676:Ankyloglossia / Q000601:surgery*; D005347:Fibroblasts / Q000502:physiology; D006053:Goldenhar Syndrome / Q000601:surgery*; D006801:Humans; D007223:Infant; D015603:Keratinocytes / Q000502:physiology; D009061:Mouth Mucosa / Q000601:surgery*; D017090:Occlusal Splints; D019651:Plastic Surgery Procedures / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*