title: The effect of dentin on the pulp tissue dissolution capacity of sodium hypochlorite and calcium hydroxide.
abstract: BACKGROUND
  Sodium hypochlorite (NaOCl) and calcium hydroxide (Ca[OH]2) have tissue dissolution capacity. The aim of this study was to evaluate the potential effect of dentin on their tissue dissolution capacity in a novel dentin model.
  
  
  METHODS
  Dentin models were prepared from 25 freshly extracted human molar teeth; the crowns were separated from the roots, and a rectangular inner shape was prepared. Pulp tissue samples adjusted to similar weights of 6.5 ± 0.2 mg were randomly divided into 6 groups: NaOCl groups in test tubes or dentin models for 1 hour, Ca(OH)2 groups in test tubes or dentin models for 1 week, and control groups saline in test tubes or dentin models for 1 week. The final weights after the experimental period were checked and compared with the initial weights. The differences were statistically analyzed.
  
  
  RESULTS
  The tissue dissolution capacity of Ca(OH)2 was affected by the presence of dentin. Similarly, NaOCl lost its effect on the pulp tissue after incubation in dentin. Comparison between all test groups showed highly significant differences (P < .001).
  
  
  CONCLUSIONS
  Dentin has a detrimental effect on the ability of NaOCl and Ca(OH)2 to dissolve pulp tissue. The dentin model appears to be an efficient tool for the study of interactions between local endodontic medicaments, dentin, and pulp tissue.
authors.affiliation: Department of Endodontics, Hadassah School of Dental Medicine, Hebrew University, Jerusalem, Israel. slutsky@netvision.net.il
authors.forename: Iris
authors.initials: I
authors.lastname: Slutzky-Goldberg
authors.forename: Aiham
authors.initials: A
authors.lastname: Hanut
authors.forename: Shlomo
authors.initials: S
authors.lastname: Matalon
authors.forename: Valery
authors.initials: V
authors.lastname: Baev
authors.forename: Hagay
authors.initials: H
authors.lastname: Slutzky
mesh_terms: D002126:Calcium Hydroxide / Q000494:pharmacology*; D003782:Dental Pulp / Q000187:drug effects*; D003804:Dentin / Q000502:physiology*; D006801:Humans; D009929:Organ Size; D012388:Root Canal Irrigants / Q000494:pharmacology*; D012973:Sodium Hypochlorite / Q000494:pharmacology*; D012995:Solubility; D013997:Time Factors
chemical_list: D012388:Root Canal Irrigants; D012973:Sodium Hypochlorite; D002126:Calcium Hydroxide
keywords: Calcium hydroxide; dentin; dissolution; pulp tissue; sodium hypochlorite