title: Variability in oxidative stress biomarkers following a maximal exercise test.
abstract: The oxidative stress response to maximal exercise may provide useful clinical biomarkers for assessing redox homeostasis. The aim was to determine the between-individual variability in the exercise-induced change in oxidative stress measures and investigate predictors of these responses. Plasma F2-isoprostanes (Isop), protein carbonyls (PCs), glutathione peroxidase (GPX) activity and total antioxidant capacity (TAC) were measured before and after a maximal treadmill exercise test. Exercise produced significant increases in Isop (27.0%), PC (6.2%) and GPX (7.8%). There were large between-individual coefficients of variation: Isop (152%), PC, (240%), GPX (130%) and TAC (243%).
authors.affiliation: Exercise and Oxidative Stress Research Group, School of Human Movement Studies, the University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Mullins
authors.forename: Simon P
authors.initials: SP
authors.lastname: van Rosendal
authors.forename: David R
authors.initials: DR
authors.lastname: Briskey
authors.forename: Robert G
authors.initials: RG
authors.lastname: Fassett
authors.forename: Gary R
authors.initials: GR
authors.lastname: Wilson
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Coombes
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002149:Energy Intake; D005080:Exercise Test; D028441:F2-Isoprostanes / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D028421:Isoprostanes / Q000097:blood*; D008297:Male; D018384:Oxidative Stress; D005082:Physical Exertion; D050050:Protein Carbonylation; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D028441:F2-Isoprostanes; D028421:Isoprostanes; D005979:Glutathione Peroxidase