title: Specificity, promiscuity, and precursor frequency in immunoreceptors.
abstract: The immune system is comprised of various immune cell populations that utilize a spectrum of immunoreceptors characterized by different levels of specificity, diversity, and prevalence within a host and across a population. These range from the universal receptors employed by both innate cells and innate-like cells, such as NKT and MAIT cells, through to receptors expressed on T cells with sporadic incidence. Here we review recent advances in understanding the molecular mechanisms that drive the observed spectra of T cell receptors in vivo.
authors.affiliation: Computational Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, New South Wales 2052, Australia. Electronic address: v.venturi@unsw.edu.au.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Venturi
authors.forename: Brian D
authors.initials: BD
authors.lastname: Rudd
authors.forename: Miles P
authors.initials: MP
authors.lastname: Davenport
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D005854:Germ Cells / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D055611:Natural Killer T-Cells / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*
chemical_list: D000941:Antigens; D006649:Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell