title: Maternal dietary canola oil suppresses growth of mammary carcinogenesis in female rat offspring.
abstract: As suggested by rodent studies and studies using human breast cancer cells, dietary canola oil is linked with lower breast cancer risk. Here, we investigated the effect of maternal (pregnancy plus lactation) dietary canola oil on the susceptibility of female Sprague-Dawley rat offspring to mammary carcinogenesis. Although the control diet had 10% soybean oil, the treatment diet was formulated to contain 10% canola oil as a fat source. N-nitroso-N-methylurea was injected to induce mammary cancer in offspring. The offspring of canola-fed dams showed significantly decreased tumor multiplicity (1.0 ± 0.3 vs. 1.9 ± 0.3, respectively; P = 0.04) and tumor volume (1232.5 ± 771.0 mm(3) vs. 6,302.5 ± 1,747.4 mm(3), respectively; P = 0.01), along with increased survival rate (87% vs. 47%, respectively; P = 0.01). In addition, the mRNA expression of development-related gamma-glutamyltransferase 1 was significantly higher in the lactating mammary tissues of the canola group dams and mammary tumor tissues of the offspring [2.5 ± 0.6 vs. 0.5 ± 0.2, respectively (P = 0.01) and 0.98 ± 0.03 vs. 0.56 ± 0.15, respectively (P = 0.05)]. These results suggest a potential anticancer effect of maternal dietary canola oil and may be useful in devising prenatal nutritional strategies to reduce breast cancer risk in humans.
authors.affiliation: Department of Animal Sciences, North Dakota State University, Fargo, North Dakota 58108, USA.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Mabasa
authors.forename: Kyongshin
authors.initials: K
authors.lastname: Cho
authors.forename: Mark W
authors.initials: MW
authors.lastname: Walters
authors.forename: Sajin
authors.initials: S
authors.lastname: Bae
authors.forename: Chung S
authors.initials: CS
authors.lastname: Park
mesh_terms: D000818:Animals; D001835:Body Weight; D063646:Carcinogenesis; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005260:Female; D007774:Lactation; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D039382:Maternal Nutritional Physiological Phenomena; D008770:Methylnitrosourea / Q000633:toxicity; D011247:Pregnancy; D000074262:Rapeseed Oil; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D000074262:Rapeseed Oil; D008770:Methylnitrosourea