title: Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates.
abstract: An expedient and simple protocol to access S-linked glycopeptides by Fmoc SPPS using unprotected carbohydrates is reported. The utility of the method was demonstrated with the solid phase synthesis of a MUC1 fragment (20 mer) containing two glycosylation sites that were substituted with S-linked glycans.
authors.affiliation: Institut de Science et Ingénierie Supramoléculaires (ISIS - UMR 7006), Université de Strasbourg - CNRS, 8 allée Gaspard Monge, F67000 Strasbourg, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Novoa
authors.forename: Sofia
authors.initials: S
authors.lastname: Barluenga
authors.forename: Christelle
authors.initials: C
authors.lastname: Serba
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
mesh_terms: D000595:Amino Acid Sequence; D002241:Carbohydrates / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D008969:Molecular Sequence Data; D018396:Mucin-1 / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques
chemical_list: D002241:Carbohydrates; D006020:Glycopeptides; D018396:Mucin-1