title: [Pancreatic acinar cell carcinoma: diagnostic and surgical treatment strategy].
abstract: OBJECTIVE
  To investigate the clinical features, diagnostic and therapeutic strategy of pancreatic acinar cell carcinoma.
  
  
  METHODS
  The data of pancreatic acinar cell carcinoma patients who underwent surgical operations from January 2002 to January 2012 were retrospectively reviewed.
  
  
  RESULTS
  Six cases of pancreatic acinar cell carcinoma, identified with pathology were collected, including 3 males and 3 females with the average of 47.8 yeas old. Upper abdominal pain was present in 5 cases, weight loss was present in 4 cases with the average of 12.5 kg. Other symptoms included nausea/vomiting, back pain and obstructive jaundice. The serum CA19-9 and CA24-2 level were significantly elevated in 2 cases. CT scan, MRI and DSA were the main imaging methods to diagnose this disease. However, no case was diagnosed as pancreatic acinar cell carcinoma before operation. All cases were confirmed by the pathological examination. Relatively high rates of surgical resection, long operative time, more blood loss and combined multi-organ resection were the characteristics of this disease's operative surgical procedures. The average period of postoperative follow-up process was 60 months, and the mean survival time was (32 ± 8) months.
  
  
  CONCLUSIONS
  The clinical features and biological behavior of pancreatic acinar cell carcinoma are different from those of ductal adenocarcinoma, while the relatively specific clinical manifestations and imaging changes will be helpful for qualitative diagnosis before operation. As it has high rate of resection and better prognosis, more radical surgical strategies should be carried out for patients of this disease.
authors.affiliation: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Jun-chao
authors.initials: JC
authors.lastname: Guo
authors.forename: Han-xiang
authors.initials: HX
authors.lastname: Zhan
authors.forename: Tai-ping
authors.initials: TP
authors.lastname: Zhang
authors.forename: Yu-pei
authors.initials: YP
authors.lastname: Zhao
mesh_terms: D000328:Adult; D018395:CA-19-9 Antigen / Q000097:blood; D018267:Carcinoma, Acinar Cell / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D018395:CA-19-9 Antigen