title: Detection of the Hematopoietic Stem and Progenitor Cell Marker CD133 during Angiogenesis in Three-Dimensional Collagen Gel Culture.
abstract: We detected the hematopoietic stem and progenitor cell marker CD133 using immunogold labeling during angiogenesis in a three-dimensional collagen gel culture. CD133-positive cells were present in capillary tubes newly formed from aortic explants in vitro. The CD133-positive cell population had the capacity to form capillary tubes. Lovastatin strongly inhibited cell migration from aortic explants and caused the degradation of the capillary tubes. The present study provides insight into the function of CD133 during angiogenesis as well as an explanation for the antiangiogenic effect of statins.
authors.affiliation: Division of Morphological Science, Biomedical Research Center, Saitama Medical University, 38 Moroyama, Iruma-gun, Saitama 350-0495, Japan.
authors.forename: Masumi
authors.initials: M
authors.lastname: Akita
authors.forename: Kayoko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Sachiko
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Kumiko
authors.initials: K
authors.lastname: Komatsu
authors.forename: Keiko
authors.initials: K
authors.lastname: Fujita