title: Association of amoxicillin use and molar incisor hypomineralization in piglets: visual and mineral density evaluation.
abstract: OBJECTIVE
  The aim of the present study was to determine the prevalence of MIH both visually and quantitatively, and describes the range of mineral densities of enamel specimens from three groups of piglets where two groups were given different doses of amoxicillin in infancy.
  
  
  METHODS
  In this blind randomized clinical study, 20 piglets were randomly divided into three groups. Group A received a standard dose (50mg/kg/day) and Group B received a high dose (90mg/kg/day) of amoxicillin in selected days of the month (20 working days) they were born. Group K did not receive any medication and served as control. Thirteen right mandibular permanent first molars (PFMs) were randomly collected from 3 groups of piglets at age 10 months for evaluation under X-ray micro-tomography. Tomographic data were obtained using a Skyscan 1174 compact micro-CT in the Department of Anatomy.
  
  
  RESULTS
  Prevalence of MIH was 0% in all groups. MD values were quantified after enamel grey level (0-255) measurements on horizontal cross-sectional slices. After MD measurements, the effects of amoxicillin use on MIH are presented.
  
  
  CONCLUSIONS
  While MIH is a multifactorial disturbance, the present study attempted to highlight the clinical findings of a possible relationship between amoxicillin use and MIH with the aid of X-ray micro-tomography.
authors.affiliation: Department of Paediatric Dentistry, Dental School, Yeditepe University, Istanbul, Turkey. ookuscu@yahoo.com
authors.forename: Ozgur Onder
authors.initials: OO
authors.lastname: Kuscu
authors.forename: Nuket
authors.initials: N
authors.lastname: Sandalli
authors.forename: Serdal
authors.initials: S
authors.lastname: Dikmen
authors.forename: Orkun
authors.initials: O
authors.lastname: Ersoy
authors.forename: Ilkan
authors.initials: I
authors.lastname: Tatar
authors.forename: Ismet
authors.initials: I
authors.lastname: Turkmen
authors.forename: Esber
authors.initials: E
authors.lastname: Caglar
mesh_terms: D000658:Amoxicillin / Q000633:toxicity*; D000818:Animals; D003744:Dental Enamel Hypoplasia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013552:Swine; D055114:X-Ray Microtomography
chemical_list: D000658:Amoxicillin
keywords: Amoxicillin; Dental hypomineralization; Enamel hypomineralization; Incisor; Molar; Penicillin V; Pig