title: Esophageal squamous cell carcinoma and gastric cardia adenocarcinoma shared susceptibility locus in PLCE1: a meta-analysis.
abstract: OBJECTIVE
  Two recent genome-wide association studies have identified a shared susceptibility variation PLCE1 rs2274223 for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA). Subsequent case-control studies have reported this association in other populations. However, the findings were controversial and the effect remains undetermined. Our aim is to provide a precise quantification of the association between PLCE1 rs2274223 variation and the risk of ESCC and GCA.
  
  
  METHODS
  Studies were identified by a literature search in MEDLINE and EMBASE databases. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association in allele, dominant, recessive, homozygous, and heterozygous models.
  
  
  RESULTS
  Ten articles were identified, including 22156 ESCC cases and 28803 controls, 5197 GCA cases and 17613 controls. Overall, PLCE1 rs2274223 G allele (G vs. A: OR=1.26, 95% CI: 1.15-1.39 for ESCC; OR=1.51, 95% CI: 1.35-1.69 for GCA) and its carrier (GG +AG vs. AA: OR = 1.23; 95% CI =1.02-1.49 for ESCC; OR =1.62; 95% CI =1.15-2.29 for GCA) were significantly associated with the risk of ESCC and GCA. In stratified analysis by ethnicity, significant association of PLCE1 rs2274223 G allele and the risk of ESCC (OR=1.33, 95% CI 1.21-1.45) and GCA (OR =1.56, 95% CI: 1.47-1.64) was observed in Chinese population.
  
  
  CONCLUSIONS
  Our meta-analysis results indicated that PLCE1 rs2274223 G allele significantly contributed to the risk of ESCC and GCA, especially in Chinese population.
authors.affiliation: Department of Laboratory Medicine, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
authors.forename: Ruiqin
authors.initials: R
authors.lastname: Mai
authors.forename: Yabin
authors.initials: Y
authors.lastname: Cheng
authors.forename: Yuanshen
authors.initials: Y
authors.lastname: Huang
authors.forename: Guohong
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016239:MEDLINE; D015233:Models, Statistical; D016017:Odds Ratio; D054801:Phosphoinositide Phospholipase C / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D054801:Phosphoinositide Phospholipase C; C423320:phospholipase C epsilon