title: Titanium dioxide nanotube modified implants: an animal study on bone formation.
abstract: This study examined the bone response to titanium dioxide nanotube modified implants. A total of 24 implants were placed in the femur of 4 beagles. Before placement, screw-shaped implants were classified into 3 groups; machined surface (group M), titanium dioxide nanotube modification of the machined surface (group MN) and titanium dioxide nanotube modification of the RBM surface (group RN). The texture morphology was observed via scanning electron microscopy. Animals were euthanized after 4 and 12 weeks of submerged healing and the histologic and histomorphometric analyses were performed. Groups MN and RN showed a significantly higher percentage of mineralized bone than that in group M (p < 0.05). The results of this in vivo study constitute significant evidence that the presence of the titanium dioxide nanotubes enhance osseointegration of implants.
authors.affiliation: Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Kwi-Dug
authors.initials: KD
authors.lastname: Yun
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Park
authors.forename: Kwang-Min
authors.initials: KM
authors.lastname: Lee
authors.forename: Hyun-Seung
authors.initials: HS
authors.lastname: Kim
authors.forename: Mong-Sook
authors.initials: MS
authors.lastname: Vang
authors.forename: Hong-So
authors.initials: HS
authors.lastname: Yang
authors.forename: Jeong-Tae
authors.initials: JT
authors.lastname: Koh
authors.forename: Seong-Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Gye-Jeong
authors.initials: GJ
authors.lastname: Oh
authors.forename: Ga-Hyun
authors.initials: GH
authors.lastname: Kim
authors.forename: Min-Kyung
authors.initials: MK
authors.lastname: Ji
authors.forename: Gab-Woon
authors.initials: GW
authors.lastname: Hwang
authors.forename: Hyun-Pil
authors.initials: HP
authors.lastname: Lim
mesh_terms: D000818:Animals; D001846:Bone Development; D004285:Dogs; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes; D019736:Prostheses and Implants; D014025:Titanium / Q000494:pharmacology*
chemical_list: C009495:titanium dioxide; D014025:Titanium