title: Prevalence of hepatic steatosis in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  Nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) both are known to be associated with insulin resistance and metabolic syndrome (MS). The aim of the study was to determine the presence of NAFLD and associated factors of hepatic steatosis in women with PCOS.
  
  
  METHODS
  A cross-sectional hospital based study of 54 women with PCOS and 55 healthy controls who were age and weight matched were included. Anthropometric parameters, biochemical and hormonal investigations were done in all the patients. Insulin resistance was calculated by Homeostasis model assessment (HOMA). Abdominal ultrasonography and biochemical tests were used to determine the presence of hepatic steatosis after excluding other causes liver disease.
  
  
  RESULTS
  Women with PCOS had a higher prevalence of hepatic steatosis (67% vs 25%, P = 0.001) MS (35% vs. 7%, P < 0.01) and elevated transaminases (31% vs. 7%, P = 0.03) than controls. All patients with PCOS and controls with MS had presence of hepatic steatosis. Age, BMI, waist-hip ratio, HOMA-IR, HDL and PCOS diagnosis were the factors associated with presence of hepatic steatosis.
  
  
  CONCLUSIONS
  NAFLD is commonly present in women with PCOS in combination with other metabolic derangements. Evaluation for liver disease should be considered at an earlier age in women with PCOS, particularly those who have an evidence of MS.
authors.affiliation: Department of Medicine, Era's Lucknow Medical College, Sarfarazganj, Hardoi Road, Lucknow, Uttar Pradesh, India.
authors.forename: Ritu
authors.initials: R
authors.lastname: Karoli
authors.forename: Jalees
authors.initials: J
authors.lastname: Fatima
authors.forename: Ashok
authors.initials: A
authors.lastname: Chandra
authors.forename: Uma
authors.initials: U
authors.lastname: Gupta
authors.forename: Faraz-Ul
authors.initials: FU
authors.lastname: Islam
authors.forename: Gagandeep
authors.initials: G
authors.lastname: Singh
keywords: Insulin resistance; metabolic syndrome; non-alcoholic fatty liver disease; polycystic ovary syndrome