title: Genetic variation of GRIN1 confers vulnerability to methamphetamine-dependent psychosis in a Thai population.
abstract: GRIN1 is a gene that encodes the N-methyl-d aspartate (NMDA) receptor subunit1 (NR1). Variations of GRIN1 have been identified as a risk factor for schizophrenia and drug dependence, supporting hypotheses of glutamatergic dysfunction in these disorders. Methamphetamine (METH) is a psychostimulant drug which can induce psychotic symptoms reminiscent of those found in schizophrenia; thus GRIN1 is a candidate gene for vulnerability to METH dependence or METH-dependent psychosis. The present study examined two polymorphisms of GRIN1, rs11146020 (G1001C) and rs1126442 (G2108A), in 100 male Thai METH-dependent patients and 103 healthy controls using PCR-RFLP techniques. Neither polymorphism was significantly associated with METH dependence, although rs1126442 was highly significantly associated with METH-dependent psychosis, in which the A allele showed reduced frequency (P<0.00001). The present findings indicate that the rs1126442 of GRIN1 contributes to the genetic vulnerability to psychosis in METH-dependent subjects in the Thai population.
authors.affiliation: Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Rachanee
authors.initials: R
authors.lastname: Chanasong
authors.forename: Samur
authors.initials: S
authors.lastname: Thanoi
authors.forename: Paritat
authors.initials: P
authors.lastname: Watiktinkorn
authors.forename: Gavin P
authors.initials: GP
authors.lastname: Reynolds
authors.forename: Sutisa
authors.initials: S
authors.lastname: Nudmamud-Thanoi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011605:Psychoses, Substance-Induced / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D012307:Risk Factors; D013785:Thailand; D055815:Young Adult
chemical_list: C485668:GRIN1 protein, human; D009419:Nerve Tissue Proteins; D016194:Receptors, N-Methyl-D-Aspartate; D008694:Methamphetamine
keywords: GRIN1; Methamphetamine; Pharmacogenetics; Psychosis; Substance misuse