title: Validity of inorganic nanosheets as an efficient planar substituent to enhance the enantioselectivity of transition-metal-catalyzed asymmetric synthesis.
abstract: Effectively enhancing the enantioselectivity is a persistent challenge in heterogeneous asymmetric catalysis. Here, the validity of a layered double hydroxides (LDH) nanosheet as an efficient planar substituent to enhance the enantioselectivity has been investigated theoretically; first in vanadium-catalyzed asymmetric epoxidation of allylic alcohols, and then in zinc-catalyzed direct asymmetric aldol addition. The computational predication is further confirmed experimentally in zinc-catalyzed direct asymmetric aldol addition by controlling the location of catalytic sites.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Box 98, 15 Beisanhuan Dong Lu, Beijing 100029 (P.R. China), Fax: (+86) 10-64425385.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Zhao
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Shi
authors.forename: Zhe
authors.initials: Z
authors.lastname: An
authors.forename: Jiu-Zhao
authors.initials: JZ
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: He
mesh_terms: D000447:Aldehydes; D002384:Catalysis; D006878:Hydroxides / Q000737:chemistry*; D020005:Propanols / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D028561:Transition Elements / Q000737:chemistry*; D014639:Vanadium; D015032:Zinc
chemical_list: D000447:Aldehydes; D006878:Hydroxides; D020005:Propanols; D028561:Transition Elements; D014639:Vanadium; C006463:allyl alcohol; C116609:3-hydroxybutanal; D015032:Zinc
keywords: asymmetric catalysis; density functional calculations; enantioselectivity; heterogeneous catalysis; nanosheets