title: [Neuroendocrine carcinoma of the digestive tract: a literature review].
abstract: Neuroendocrine carcinoma is a rare and agressive malignant tumor, mainly developing at the expense of the respiratory and of the digestive tract. Among the digestive tract, appendix, small bowel, and pancreas are the preferential sites of involvement, other locations have been more rarely reported. Neuroendocrine digestive tumors may present with various symptoms in relationship with their localization and a complex pathophysiology. Diagnosis is often made at an advanced stage, explaining partly the bad prognosis of these tumors. The optimal management of digestive neuroendocrine tumors is rendered difficult by their rarity and by a low number of randomized trials. We review the literature regarding epidemiologic and prognostic features of these rare tumors, their diagnostic and therapeutic care. Potential complications are also discussed.
authors.affiliation: Service d'oncologie-radiothérapie, hôpital d'instruction des armées du Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France. Electronic address: julian.jacob28@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Jacob
authors.forename: C
authors.initials: C
authors.lastname: Chargari
authors.forename: C
authors.initials: C
authors.lastname: Helissey
authors.forename: F-R
authors.initials: FR
authors.lastname: Ferrand
authors.forename: B
authors.initials: B
authors.lastname: Ceccaldi
authors.forename: S
authors.initials: S
authors.lastname: Le Moulec
authors.forename: O
authors.initials: O
authors.lastname: Bauduceau
authors.forename: M
authors.initials: M
authors.lastname: Fayolle
authors.forename: L
authors.initials: L
authors.lastname: Védrine
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D003938:Diagnostic Techniques, Digestive System; D004067:Digestive System Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy; D058990:Molecular Targeted Therapy
keywords: Appareil digestif; Carcinome neuro-endocrine; Chemotherapy; Chimiothérapie; Digestive tract; Neuroendocrine carcinoma