title: Oesophageal hyperkeratosis: clinicopathological associations.
abstract: OBJECTIVE
  Oesophageal hyperkeratosis is rarely described. In contrast to hyperkeratosis of orolaryngeal mucosa, where its risk factors and association with squamous neoplasia are well-studied, the prevalence and clinicopathological features of oesophageal hyperkeratosis are unknown.
  
  
  RESULTS
  We reviewed prospectively 1845 oesophageal biopsies and found hyperkeratosis in 37 (2.0%). Among 98 patients studied, hyperkeratosis occurred in two distinct settings: group 1 [within Barrett's oesophagus (BO)/adenocarcinoma, n = 61, 62%] and group 2 (outside BO/adenocarcinoma, n = 37, 38%). In contrast to group 1, hyperkeratosis in group 2 was more often multifocal (>3 foci in 51% versus 16%, P = 0.0001), involved mid-oesophagus (51% versus 2%, P < 0.0001), showed endoscopic leucoplakia (24% versus 3%, P = 0.003) and involved current/former alcohol users (51% versus 19%, P = 0.0012). Importantly, invasive squamous carcinoma and squamous dysplasia were seen only in group 2 (47% and 19% versus 0%, P < 0.0001). Further, 42% of group 2, but none of group 1, had benign or malignant squamous lesions of the oral cavity/larynx (P < 0.0001).
  
  
  CONCLUSIONS
  Hyperkeratosis involves ~2% of oesophageal biopsies and can be divided into cases occurring within BO/adenocarcinoma and those occurring outside BO/adenocarcinoma. The former lack clinical significance, whereas the latter are associated frequently with oesophageal squamous neoplasia and squamous pathology of the head and neck region.
authors.affiliation: Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: Melissa W
authors.initials: MW
authors.lastname: Taggart
authors.forename: Asif
authors.initials: A
authors.lastname: Rashid
authors.forename: William A
authors.initials: WA
authors.lastname: Ross
authors.forename: Susan C
authors.initials: SC
authors.lastname: Abraham
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000150:complications; D004935:Esophageal Diseases / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000150:complications; D005260:Female; D006801:Humans; D007642:Keratosis / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies
keywords: hyperkeratosis; leucoplakia; oesophagus; parakeratosis; squamous carcinoma; squamous dysplasia