title: The cyclin D1 (CCND1) G870A polymorphism and lung cancer susceptibility: a meta-analysis.
abstract: Several studies have investigated the association between Cyclin D1 (CCND1) G870A genetic polymorphism and lung cancer susceptibility, but the results were inconclusive. The aim of this meta-analysis was to summarize available evidence for such a relationship. The reviewers made use of MEDLINE, EMBASE, and BIOSIS databases. The relevant data were independently extracted by two reviewers. The odds ratio (OR) with 95% confidence interval (CI) was selected as the principal outcome measure. The heterogeneity test, the publication bias test, and the sensitivity analysis were performed. Overall, a total of 10 case-control studies were included. Our meta-analysis indicated that CCND1 G870A genetic polymorphism was a risk factor for lung cancer under homozygote model (OR = 1.18; 95% CI = 1.02, 1.37), recessive model (OR = 1.21; 95% CI = 1.03, 1.41), and allele model (OR = 1.11; 95% CI = 1.02, 1.21). In the subgroup analysis by source of ethnicity, a statistical increase of lung cancer risk was found among Asian groups for allele model (OR = 1.11; 95% CI = 1.01-1.22). The present meta-analysis suggests that CCND1 G870A polymorphism may be a risk factor for lung cancer. Besides, allele A may contribute to increased lung cancer risk.
authors.affiliation: Nanlou Respiratory Diseases Department, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, People's Republic of China.
authors.forename: Changxi
authors.initials: C
authors.lastname: Zhou
authors.forename: Huaijie
authors.initials: H
authors.lastname: An
authors.forename: Mingdong
authors.initials: M
authors.lastname: Hu
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Liu
authors.forename: Peiliang
authors.initials: P
authors.lastname: Geng
authors.forename: Jiancheng
authors.initials: J
authors.lastname: Xu
authors.forename: Baojun
authors.initials: B
authors.lastname: Sun
authors.forename: Changting
authors.initials: C
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D019938:Cyclin D1 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D019938:Cyclin D1