title: Synthesis of functionalized isoquinolin-1(2H)-ones by copper-catalyzed α-arylation of ketones with 2-halobenzamides.
abstract: Copper is key: A concise route to isoquinolin-1(2H)-ones from simple and readily available starting materials is provided by an efficient copper-catalyzed annulation of ketones with 2-halobenzamides. The method is applicable to a wide range of ketones containing different functional groups furnishing the products in moderate to excellent yields.
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Xuebin
authors.initials: X
authors.lastname: Zhu
authors.forename: Haibin
authors.initials: H
authors.lastname: Mao
authors.forename: Hongwen
authors.initials: H
authors.lastname: Hu
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001549:Benzamides; D007546:Isoquinolines; D007659:Ketones; D003300:Copper
keywords: copper; heterocycles; isoquinolin-1(2H)-ones; synthetic methods; α-arylation