title: Rifampicin-associated acute renal failure and hemolysis: a rather uncommon but severe complication.
abstract: Rifampicin is a widely used anti-tuberculosis agent. Apart from hepatotoxicity, rifampicin can rarely lead to adverse reactions of immunologic nature such as acute renal failure (ARF). We report the case of 57-year-old previously healthy man under treatment for pulmonary tuberculosis who presented with hemolysis and severe ARF. Rifampicin was discontinued and the patient was treated with fluid repletion, iv furosemide and dialysis therapy. Kidney biopsy revealed acute tubulointerstitial nephritis with no evidence of granulomas. The patient significantly improved and was discharged after 51 days of hospitalization. Clinicians using rifampicin should be aware of this rather uncommon but severe complication.
authors.affiliation: Pulmonary Department, Aristotle University of Thessaloniki, G. Papanikolaou Hospital, Exohi, Thessaloniki, Greece.
authors.forename: Katerina
authors.initials: K
authors.lastname: Manika
authors.forename: Karmen
authors.initials: K
authors.lastname: Tasiopoulou
authors.forename: Leuteris
authors.initials: L
authors.lastname: Vlogiaris
authors.forename: Martha
authors.initials: M
authors.lastname: Lada
authors.forename: Styliani
authors.initials: S
authors.lastname: Papaemmanouil
authors.forename: Konstaninos
authors.initials: K
authors.lastname: Zarogoulidis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kioumis
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D006461:Hemolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000904:Antibiotics, Antitubercular; D012293:Rifampin