title: Association of serum myeloid cells of soluble triggering receptor-1 level with myocardial dysfunction in patients with severe sepsis.
abstract: OBJECTIVE
  To investigate the association of serum sTREM-1 with myocardial dysfunction in patients with severe sepsis.
  
  
  METHODS
  A total of 85 patients with severe sepsis were divided into severe sepsis group (n = 40) and septic shock group (n = 45). Serum levels of sTREM-1, NT-proBNP, APACHE II score, SOFA score, cardiac index, cardiac function index, global ejection fraction, and left ventricular contractility index were measured on days 1, 3, and 7 after admission to ICU.
  
  
  RESULTS
  Serum sTREM-1 levels of patients with septic shock were significantly higher than those with severe sepsis on days 1, 3, and 7. Serum sTREM-1 was positively correlated with APACHE II scores, SOFA scores, and NT-proBNP. However, The sTREM-1 level was markedly negatively correlated with CI, CFI, GEF, and dP/dt max, respectively. Multiple logistic regression analysis showed that sTREM-1 was independent risk factor to NT-proBNP increasing. The optimal cut-off point of sTREM-1 for detecting patients with myocardial dysfunction was 468.05 ng/mL with sensitivity (80.6%) and specificity (75.7%). There is no difference in TREM-1-mRNA expression between the two groups.
  
  
  CONCLUSIONS
  Serum sTREM-1 is significantly associated with myocardial dysfunction and may be a valuable tool for determining the presence of myocardial dysfunction in patients with severe sepsis.
authors.affiliation: Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical College, No. 57 Southern Renmin Avenue, Zhanjiang, Guangdong 524023, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Tao
authors.forename: Liangshan
authors.initials: L
authors.lastname: Peng
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
authors.forename: Liehua
authors.initials: L
authors.lastname: Deng
authors.forename: Huaguo
authors.initials: H
authors.lastname: Yao
mesh_terms: D000368:Aged; D009202:Cardiomyopathies / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood* / Q000502:physiology; D008875:Middle Aged; D022423:Myeloid Cells / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011971:Receptors, Immunologic / Q000097:blood* / Q000502:physiology; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000378:metabolism*; D012720:Severity of Illness Index; D012772:Shock, Septic; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D008562:Membrane Glycoproteins; D010446:Peptide Fragments; D012333:RNA, Messenger; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain