title: Dendrimers in layer-by-layer assemblies: synthesis and applications.
abstract: We review the synthesis of dendrimer-containing layer-by-layer (LbL) assemblies and their applications, including biosensing, controlled drug release, and bio-imaging. Dendrimers can be built into LbL films and microcapsules by alternating deposition of dendrimers and counter polymers on the surface of flat substrates and colloidal microparticles through electrostatic bonding, hydrogen bonding, covalent bonding, and biological affinity. Dendrimer-containing LbL assemblies have been used to construct biosensors, in which electron transfer mediators and metal nanoparticles are often coupled with dendrimers. Enzymes have been successfully immobilized on the surface of electrochemical and optical transducers by forming enzyme/dendrimer LbL multilayers. In this way, high-performance enzyme sensors are fabricated. In addition, dendrimer LbL films and microcapsules are useful for constructing drug delivery systems because dendrimers bind drugs to form inclusion complexes or the dendrimer surface is covalently modified with drugs. Magnetic resonance imaging of cancer cells by iron oxide nanoparticles coated with dendrimer LbL film is also discussed.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Sato
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Anzai
mesh_terms: D015374:Biosensing Techniques; D050091:Dendrimers / Q000737:chemistry* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D004563:Electrochemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D050091:Dendrimers; D011108:Polymers