title: Increased expression of sex determining region Y-box 11 (SOX11) in cutaneous malignant melanoma.
abstract: OBJECTIVE
  To observe sex determining region Y-box 11 (SOX11) gene expression in cutaneous malignant melanoma and its effect on tumour cell proliferation.
  
  
  METHODS
  Clinicopathological data and tissue samples from patients with cutaneous malignant melanoma, together with tissue samples from healthy volunteers (controls), were retrospectively reviewed. Protein levels of SOX11 and the antigen identified by monoclonal antibody Ki-67 (Ki-67) in skin lesions were analysed using immunohistochemistry. The correlation between protein levels and clinipathological parameters was investigated.
  
  
  RESULTS
  Out of 40 patient samples, 25 (62.5%) were positive for SOX11 protein in malignant melanoma tissue. This was significantly higher than in 40 control tissue samples, in which no SOX11 protein was detected. Presence of SOX11 protein was positively related to the proliferation index of cutaneous malignant melanoma tumour cells. Presence of SOX11 protein in cutaneous malignant melanoma was related to tumour type, tumour location, lymph node metastasis and 5-year survival rate.
  
  
  CONCLUSIONS
  Human cutaneous malignant melanoma tissues expressed high levels of SOX11 compared with healthy controls, suggesting that SOX11 may be a new prognostic marker for malignant melanoma.
authors.affiliation: Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China. skinwym@yahoo.cn
authors.forename: Jiao
authors.initials: J
authors.lastname: Jian
authors.forename: Wang
authors.initials: W
authors.lastname: Guoying
authors.forename: Zhao
authors.initials: Z
authors.lastname: Jing
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D049109:Cell Proliferation; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000235:genetics; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055751:SOXC Transcription Factors / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis; D000096142:Cutaneous Malignant Melanoma
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; C097473:SOX11 protein, human; D055751:SOXC Transcription Factors
keywords: Malignant melanoma; antigen identified by monoclonal antibody Ki-67 (Ki-67); cell proliferation; prognosis; sex determining region Y-box 11 (SOX11); survival rate