title: Novel therapeutics for the treatment of familial Mediterranean fever: from colchicine to biologics.
abstract: Familial Mediterranean fever (FMF), an inherited autosomal recessive disorder, is characterized by sporadic, paroxysmal attacks of fever and serosal inflammation, lasting 1-3 days. Patients may develop renal amyloidosis, arthritis, serositis, and skin and oral lesions. Diagnosis is based on clinical features, response to treatment with colchicine, and genetic analysis. Colchicine prevents attacks and renal amyloidosis, in addition to reversing proteinuria. Nonresponders may receive novel therapy, including interleukin (IL)-1 receptor antagonists and IL-1 decoy receptor. Recently, new options have been considered.
authors.affiliation: College of General Practitioners, Florence and Bari, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Grattagliano
authors.affiliation: Clinica Medica "A. Murri," Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bonfrate
authors.affiliation: Clinica Medica "A. Murri," Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Ruggiero
authors.affiliation: 1] Clinica Medica "A. Murri," Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy [2] Gastrointestinal Endoscopy, "Umberto I" Hospital, Altamura, Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Scaccianoce
authors.affiliation: Clinica Medica "A. Murri," Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Palasciano
authors.affiliation: 1] Clinica Medica "A. Murri," Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy [2] European Society for Clinical Investigation, Utrecht, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Portincasa
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000627:therapeutic use*; D003078:Colchicine / Q000737:chemistry / Q000627:therapeutic use*; D055808:Drug Discovery / Q000639:trends*; D010505:Familial Mediterranean Fever / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000737:chemistry / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D001688:Biological Products; D053590:Interleukin 1 Receptor Antagonist Protein; D003078:Colchicine