title: Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform.
abstract: We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.
authors.affiliation: Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. willem.mulder@mssm.edu.
authors.forename: Anita
authors.initials: A
authors.lastname: Gianella
authors.forename: Aneta J
authors.initials: AJ
authors.lastname: Mieszawska
authors.forename: Freek J M
authors.initials: FJ
authors.lastname: Hoeben
authors.forename: Henk M
authors.initials: HM
authors.lastname: Janssen
authors.forename: Peter A
authors.initials: PA
authors.lastname: Jarzyna
authors.forename: David P
authors.initials: DP
authors.lastname: Cormode
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Costa
authors.forename: Satish
authors.initials: S
authors.lastname: Rao
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.forename: Zahi A
authors.initials: ZA
authors.lastname: Fayad
authors.forename: Willem J M
authors.initials: WJ
authors.lastname: Mulder
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry*; D005434:Flow Cytometry; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000737:chemistry; D020778:Matrix Metalloproteinase 2 / Q000737:chemistry; D051379:Mice; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004655:Emulsions; D039302:Integrin alphaVbeta3; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; D020778:Matrix Metalloproteinase 2