title: [A case of gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor].
abstract: We report a case of gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor (G-CSF). A 60- year-old man was admitted to our hospital complaining of upper abdominal pain. Endoscopic examination revealed a large type 5 advanced gastric cancer with bleeding from the low body of stomach to the antrum, accompanied with para-aortic and mesenteric lymph node metastasis. He had marked leukocytosis, and serum levels of G-CSF were elevated. Histological diagnosis of the biopsy specimen was adenosquamous carcinoma producing G-CSF. We attempted combination chemotherapy with docetaxel, cisplatin and S-1(DCS). After 1 course of treatment, the primary lesion was reduced in size. However, the size of the metastatic lymph node was larger. Chemotherapy was not effective enough, and the patient died 3 months after ending chemotherapy.
authors.affiliation: Dept. of Gastroenterological Surgery, Kanazawa University, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Saito
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Oyama
authors.forename: Sachio
authors.initials: S
authors.lastname: Fushida
authors.forename: Tomoya
authors.initials: T
authors.lastname: Tsukada
authors.forename: Kouichi
authors.initials: K
authors.lastname: Okamoto
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Nakanuma
authors.forename: Jun
authors.initials: J
authors.lastname: Kinoshita
authors.forename: Isamu
authors.initials: I
authors.lastname: Makino
authors.forename: Keishi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hironori
authors.initials: H
authors.lastname: Hayashi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Inokuchi
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Nakagawara
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Miyashita
authors.forename: Hideto
authors.initials: H
authors.lastname: Fujita
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Tajima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takamura
authors.forename: Itasu
authors.initials: I
authors.lastname: Ninomiya
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000097:blood*; D001706:Biopsy; D018196:Carcinoma, Adenosquamous / Q000737:chemistry* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D002945:Cisplatin / Q000627:therapeutic use; D000077143:Docetaxel; D004338:Drug Combinations; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood* / Q000737:chemistry; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D043823:Taxoids / Q000627:therapeutic use; D005641:Tegafur / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D004338:Drug Combinations; D043823:Taxoids; D016179:Granulocyte Colony-Stimulating Factor; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid; D002945:Cisplatin