title: Association of FTO and PPARG polymorphisms with obesity in Portuguese women.
abstract: OBJECTIVE
  We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282.
  
  
  METHODS
  A total of 194 Portuguese premenopausal female Caucasians aged between 18 and 50 years (95 with body mass index [BMI] ≥30 g/m(2), 99 controls with BMI 18.5-24.9 kg/m(2)) participated in this study. The association of the single-nucleotide polymorphisms with obesity was determined by odds ratio calculation with 95% confidence intervals.
  
  
  RESULTS
  Significant differences in allelic expression of FTO rs9939609 (P<0.05) were found between control and case groups, indicating a 2.5-higher risk for obesity in the presence of both risk alleles when comparing the control group with the entire obese group. A fourfold-higher risk was found for subjects with class III obesity compared to those with classes I and II. No significant differences in BMI were found between the control and case groups for PPARG rs1801282 (P>0.05).
  
  
  CONCLUSIONS
  For the first time, a study involving an adult Portuguese population shows that individuals harboring both risk alleles in the FTO gene locus are at higher risk for obesity, which is in agreement to what has been reported for other European populations.
authors.affiliation: Centro de Investigação em Genética Molecular Humana, Universidade Nova de Lisboa, Caparica, Portugal ; Investigação e Serviços em Ciências Biológicas, Stab Vida, Caparica, Portugal.
authors.forename: Fábio Ferreira
authors.initials: FF
authors.lastname: Carlos
authors.forename: José
authors.initials: J
authors.lastname: Silva-Nunes
authors.forename: Orfeu
authors.initials: O
authors.lastname: Flores
authors.forename: Miguel
authors.initials: M
authors.lastname: Brito
authors.forename: Gonçalo
authors.initials: G
authors.lastname: Doria
authors.forename: Luísa
authors.initials: L
authors.lastname: Veiga
authors.forename: Pedro Viana
authors.initials: PV
authors.lastname: Baptista
keywords: BMI; SNP; odds ratio; rs1801282; rs9939609