title: A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community.
abstract: OBJECTIVE
  The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons.
  
  
  METHODS
  This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength.
  
  
  RESULTS
  Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors.
  
  
  CONCLUSIONS
  Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.
authors.affiliation: Division of Social Medicine, Department of Environmental Medicine, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nangoku-shi, Kochi, 783-8505, Japan, andersonbasilua@yahoo.fr.
authors.forename: Basilua Andre
authors.initials: BA
authors.lastname: Muzembo
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Nagano
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Eitoku
authors.forename: Nlandu Roger
authors.initials: NR
authors.lastname: Ngatu
authors.forename: Tomomi
authors.initials: T
authors.lastname: Matsui
authors.forename: Sabah Asif
authors.initials: SA
authors.lastname: Bhatti
authors.forename: Ryoji
authors.initials: R
authors.lastname: Hirota
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishida
authors.forename: Narufumi
authors.initials: N
authors.lastname: Suganuma
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D003430:Cross-Sectional Studies; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018737:Hand Strength; D006801:Humans; D007564:Japan; D008297:Male; D053580:Muscle Strength; D018384:Oxidative Stress; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine