title: Increased 177Lu-DOTATATE uptake in Paget disease.
abstract: A 45-year-old female patient was referred for peptide receptor radionuclide therapy of liver metastases of neuroendocrine origin; the patient had undergone 2 years earlier surgical resection of a grade 2 neuroendocrine neoplasm of ampulla of Vater infiltrating the duodenal submucosa and muscular layers and the neighboring pancreatic tissue. Post-therapy whole-body scan performed to evaluate in vivo radiopharmaceutical distribution confirmed high accumulation in liver lesions and revealed increased uptake in the hip bone. Bone scan and corresponding CT images demonstrated changes of Paget disease in the same district.
authors.affiliation: From the Department of Biomedical Sciences and of Morphological and Functional Images, University of Messina, 98125 Messina - Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Minutoli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sindoni
authors.forename: Davide
authors.initials: D
authors.lastname: Cardile
authors.forename: Giorgio Restifo
authors.initials: GR
authors.lastname: Pecorella
authors.forename: Sergio
authors.initials: S
authors.lastname: Baldari
mesh_terms: D001842:Bone and Bones / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D015282:Octreotide / Q000031:analogs & derivatives; D009942:Organometallic Compounds; D010001:Osteitis Deformans / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D009942:Organometallic Compounds; D017481:Receptors, Somatostatin; C447941:lutetium Lu 177 dotatate; D015282:Octreotide