title: Intranasal infusion of nanostructured lipid carriers (NLC) containing CNS acting drug and estimation in brain and blood.
abstract: The present study was aimed to evaluate the nanostrucured lipid carriers (NLC) containing duloxetine (DLX-NLC) for intranasal infusion through the nasal cavity of rat. The in vivo nasal infusion studies were performed using Wistar rats and the amount of DLX permeated and its amount in brain and blood was estimated. The effects on absorption rate and type of drug delivery systems (nanocarriers and drug solution) for nose to brain/blood permeation were assessed. DLX was found to be permeated from the nasal cavity into the body of rat and the permeated amount was found to be more in case of DLX-NLC. Approximately 2.5-times better permeation was exhibited by DLX-NLC than DLX-solution. Appreciable amount of DLX was estimated in blood and brain and the estimated amount was higher in case of DLX-NLC. Thus the administration of NLC containing DLX through intranasal route was found to be potential method for the delivery of DLX for the treatment of depression.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
authors.forename: M Intakhab
authors.initials: MI
authors.lastname: Alam
authors.forename: Sanjula
authors.initials: S
authors.lastname: Baboota
authors.forename: Alka
authors.initials: A
authors.lastname: Ahuja
authors.forename: Mushir
authors.initials: M
authors.lastname: Ali
authors.forename: Javed
authors.initials: J
authors.lastname: Ali
authors.forename: Jasjeet K
authors.initials: JK
authors.lastname: Sahni
mesh_terms: D000042:Absorption; D000281:Administration, Intranasal; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D001921:Brain / Q000378:metabolism*; D000068736:Duloxetine Hydrochloride; D005260:Female; D008055:Lipids / Q000008:administration & dosage*; D008297:Male; D049329:Nanostructures; D009297:Nasal Mucosa / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013876:Thiophenes / Q000008:administration & dosage* / Q000493:pharmacokinetics*
chemical_list: D000928:Antidepressive Agents; D008055:Lipids; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride