title: Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications.
abstract: A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end groups for further functionalization. The suitability of these PEG derivatives to be conjugated to nanomaterials was shown by pegylation of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles (NPs), followed by functionalization with small peptide ligands for biomedical applications.
authors.affiliation: Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Batochime, CH-1015 Lausanne, Switzerland.
authors.forename: Solène
authors.initials: S
authors.lastname: Passemard
authors.forename: Davide
authors.initials: D
authors.lastname: Staedler
authors.forename: Lucia
authors.initials: L
authors.lastname: Učňová
authors.forename: Guillaume Stéphane
authors.initials: GS
authors.lastname: Schneiter
authors.forename: Phally
authors.initials: P
authors.lastname: Kong
authors.forename: Luigi
authors.initials: L
authors.lastname: Bonacina
authors.forename: Lucienne
authors.initials: L
authors.lastname: Juillerat-Jeanneret
authors.forename: Sandrine
authors.initials: S
authors.lastname: Gerber-Lemaire
mesh_terms: D045744:Cell Line, Tumor; D003911:Dextrans / Q000009:adverse effects / Q000737:chemistry*; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D058185:Magnetite Nanoparticles / Q000009:adverse effects / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis*; D009842:Oligopeptides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D003911:Dextrans; D058185:Magnetite Nanoparticles; D009842:Oligopeptides; C097921:ferumoxtran-10; D011092:Polyethylene Glycols
keywords: Cancer cells targeting; Functionalized nanoparticles; Heterotelechelic PEG oligomer; Pegylation; Selective monoreduction; USPIO NPs