title: The 2518 A/G polymorphism in the MCP-1 gene and cancer risk: a meta-analysis.
abstract: BACKGROUND
  The 2518 A/G polymorphism in the MCP-1 gene has been extensively studied for associations with cancer; however, results from replication studies have been inconsistent. The aim of this investigation was to determine links with risk of cancer by meta-analysis.
  
  
  METHODS
  We searched Pubmed, Embase, CNKI, Weipu and Wanfang databases, covering all case-control studies until March, 2013. Statistical analyses were performed using the Revman 5.0 software.
  
  
  RESULTS
  A total of 11 case-control studies met our inclusion criteria, including 1,422 cases and 2,237 controls. The results indicated that the MCP-1 2518 gene polymorphism had no association with cancer risk overall (GG vs.GA+ AA: OR = 0.89, 95%CI = 0.61-1.28, P = 0.52). However, in the subgroup analysis by ethnicity, a decrease of cancer risk was found in Asian populations (GG vs.GA+ AA: OR = 0.79, 95%CI = 0.63-0.99, P = 0.04).
  
  
  CONCLUSIONS
  This meta-analysis suggested that the 2518A/G polymorphism of MCP-1 gene is associated with risk of cancer among Asian, but not in Caucasian populations.
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
authors.forename: Liu-Qun
authors.initials: LQ
authors.lastname: Jia
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Shen
authors.forename: Shu-Jin
authors.initials: SJ
authors.lastname: Guo
authors.forename: Qian-Jing
authors.initials: QJ
authors.lastname: Hu
authors.forename: Cai-Shuang
authors.initials: CS
authors.lastname: Pang
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Wen
mesh_terms: D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2