title: Globally expanding carbapenemase finally appears in Spain: nosocomial outbreak of acinetobacter baumannii producing plasmid-encoded OXA-23 in Barcelona, Spain.
abstract: Resistance of Acinetobacter baumannii clinical isolates to carbapenems is on the rise worldwide mainly in association with the production of OXA-23. Until recently, however, OXA-23 was absent in Spain. In this work, we report the molecular characterization of a hospital outbreak of OXA-23-producing A. baumannii in Barcelona caused by a multidrug-resistant (MDR) clone belonging to international clone IC-II/sequence type ST85 between October 2010 and May 2011. blaOXA-23 was carried in a plasmid of 90 kb and located within the composite transposon Tn2006.
authors.affiliation: Department of Clinical Microbiology, School of Medicine, IDIBAPS and Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain.
authors.forename: Noraida
authors.initials: N
authors.lastname: Mosqueda
authors.forename: Paula
authors.initials: P
authors.lastname: Espinal
authors.forename: Clara
authors.initials: C
authors.lastname: Cosgaya
authors.forename: Sergio
authors.initials: S
authors.lastname: Viota
authors.forename: Virginia
authors.initials: V
authors.lastname: Plasensia
authors.forename: Francisco
authors.initials: F
authors.lastname: Alvarez-Lerma
authors.forename: Milagro
authors.initials: M
authors.lastname: Montero
authors.forename: Julià
authors.initials: J
authors.lastname: Gómez
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Horcajada
authors.forename: Jordi
authors.initials: J
authors.lastname: Vila
authors.forename: Ignasi
authors.initials: I
authors.lastname: Roca
mesh_terms: D040981:Acinetobacter baumannii / Q000201:enzymology* / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction; D013030:Spain; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase