title: Mild diabetes models and their maternal-fetal repercussions.
abstract: The presence of diabetes in pregnancy leads to hormonal and metabolic changes making inappropriate intrauterine environment, favoring the onset of maternal and fetal complications. Human studies that explore mechanisms responsible for changes caused by diabetes are limited not only for ethical reasons but also by the many uncontrollable variables. Thus, there is a need to develop appropriate experimental models. The diabetes induced in laboratory animals can be performed by different methods depending on dose, route of administration, and the strain and age of animal used. Many of these studies are carried out in neonatal period or during pregnancy, but the results presented are controversial. So this paper, addresses the review about the different models of mild diabetes induction using streptozotocin in pregnant rats and their repercussions on the maternal and fetal organisms to propose an adequate model for each approached issue.
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, Brazil.
authors.forename: D C
authors.initials: DC
authors.lastname: Damasceno
authors.forename: Y K
authors.initials: YK
authors.lastname: Sinzato
authors.forename: A
authors.initials: A
authors.lastname: Bueno
authors.forename: A O
authors.initials: AO
authors.lastname: Netto
authors.forename: B
authors.initials: B
authors.lastname: Dallaqua
authors.forename: F Q
authors.initials: FQ
authors.lastname: Gallego
authors.forename: I L
authors.initials: IL
authors.lastname: Iessi
authors.forename: S B
authors.initials: SB
authors.lastname: Corvino
authors.forename: R G
authors.initials: RG
authors.lastname: Serrano
authors.forename: G
authors.initials: G
authors.lastname: Marini
authors.forename: F
authors.initials: F
authors.lastname: Piculo
authors.forename: I M P
authors.initials: IM
authors.lastname: Calderon
authors.forename: M V C
authors.initials: MV
authors.lastname: Rudge
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D016640:Diabetes, Gestational / Q000378:metabolism / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism / Q000503:physiopathology*