title: Thyroid function: comparison of women in late pregnancy with control women of reproductive age in regions of dietary iodine excess.
abstract: Three hundred pregnant women and 300 women of reproductive age (controls) were selected from regions with a dietary iodine excess to evaluate thyroid and autoimmune thyroid functions. Fasting morning urine and venous blood samples were collected. Urinary iodine concentration, serum free tri-iodothyronine (FT3), free thyroxine (FT4), sensitive thyroid stimulating hormone (sTSH), serum thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) levels were determined. Iodine levels were excessive in 83.7% of pregnant women and 80.7% of the control women. The former showed lower rates of total thyroid disease and subclinical hypothyroidism than the latter (21.7% vs 29.7%, P < 0.05; 19.7% vs 27.3%, P < 0.05). The FT3 level, FT4 level, and TGAb positive rate of pregnant women were lower than that in the controls (P < 0.05). Thus, both excessive iodine intake and pregnancy can influence the thyroid and autoimmune thyroid functions of women.
authors.affiliation: Department of Gynecology, People's Hospital of Zhengzhou, China.
authors.forename: Quxiao
authors.initials: Q
authors.lastname: Du
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Yao
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D016022:Case-Control Studies; D002681:China; D004032:Diet / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000097:blood; D007455:Iodine / Q000008:administration & dosage* / Q000009:adverse effects* / Q000652:urine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D013954:Thyroglobulin / Q000097:blood; D013959:Thyroid Diseases / Q000139:chemically induced*; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood
chemical_list: D001323:Autoantibodies; D014284:Triiodothyronine; D013972:Thyrotropin; D013954:Thyroglobulin; D007455:Iodine; D007453:Iodide Peroxidase; D013974:Thyroxine
keywords: autoimmune thyroid function; excessive iodine; pregnant women; reproductive-age women; thyroid function