title: [Research progress of mechanism and prevention of peritendinous adhesions].
abstract: OBJECTIVE
  To review the research progress of mechanism and prevention of peritendinous adhesions. Methods Recent literature about peritendinous adhesions was reviewed, and the results from experiments about the mechanism and prevention of peritendinous adhesions were analyzed.
  
  
  RESULTS
  The molecular mechanism of peritendinous adhesions is related to overexpressions of transforming growth factor beta 1, early growth response protein 1, matrix metallopeptidase 9, and so on. The present methods of prevention of peritendinous adhesions include drugs, barrier, optimizing rehabilitation, gene therapy, and so on. These methods have achieved good results in experiments, but the clinical applications have not been confirmed yet.
  
  
  CONCLUSIONS
  It is necessary to pay more attention to the research of mechanism of peritendinous adhesions and methods of its prevention and subsequently to convert them into clinical applications, which is significant to the prevention of peritendinous adhesions in the future.
authors.affiliation: Department of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R.China.
authors.forename: Shichao
authors.initials: S
authors.lastname: Jiang
authors.forename: Shen
authors.initials: S
authors.lastname: Liu
authors.forename: Cunyi
authors.initials: C
authors.lastname: Fan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000008:administration & dosage; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage; D007052:Ibuprofen / Q000008:administration & dosage; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008567:Membranes, Artificial; D015915:Motion Therapy, Continuous Passive; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D013708:Tendon Injuries / Q000473:pathology / Q000601:surgery*; D000267:Tissue Adhesions / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D053773:Transforming Growth Factor beta1; D006820:Hyaluronic Acid; D020780:Matrix Metalloproteinase 9; D007052:Ibuprofen