title: [Quality of life in multiple sclerosis--association with clinical features, fatigue and depressive syndrome].
abstract: BACKGROUND
  The aim of the study was to assess the health related quality of life in patients suffering from multiple sclerosis (MS) in association with clinical features, fatigue and depressive symptoms.
  
  
  METHODS
  The examined group consisted of 61 patients (45 women and 16 men) in the mean age of 38.6 +/- 11.4. The mean duration of disease was 7.1 +/- 6.1 years. The control group consisted of 30 healthy volunteers. The following questionnaires were used: EuroQol (EQ5D) with visual scale EuroQol-VAS, Modified Impact Fatigue Scale (MIFS) and Beck Depression Inventory (BDI).
  
  
  RESULTS
  The quality of life in the examined group of MS patients was significantly lower in comparison to the control group. Results of EQ-5D and EQ-VAS were influenced by age, disease course, level of disability and carried treatment. Statistically significant association was also found between results of the questionnaires assessing quality of life and either fatigue or depressive symptoms.
  
  
  CONCLUSIONS
  The used questionnaires confirmed that quality of life in patients with MS is significantly worse, especially in the older people with secondary progressive course of the disease, more disable and not treated. Presence of fatigue and depressive symptoms influenced the self-assessment of quality of life. Complex care of MS patient should consider diagnosis and treatment of fatigue and depression which could improve their quality of life.
authors.affiliation: Katedra i Klinika Neurologii w Zabrzu, Slaski Uniwersytet Medyczny w Katowicach.
authors.forename: Beata
authors.initials: B
authors.lastname: Łabuz-Roszak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kubicka-Baczyk
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pierzchała
authors.forename: Maciej
authors.initials: M
authors.lastname: Horyniecki
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Machowska-Majchrzak
authors.forename: Daria
authors.initials: D
authors.lastname: Augustyńska-Mutryn
authors.forename: Konrad
authors.initials: K
authors.lastname: Kosałka
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Michalski
authors.forename: Dominika
authors.initials: D
authors.lastname: Pyszak
authors.forename: Joanna
authors.initials: J
authors.lastname: Wach
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D001007:Anxiety / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology* / Q000523:psychology*; D006233:Persons with Disabilities / Q000523:psychology / Q000706:statistics & numerical data; D005221:Fatigue / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012307:Risk Factors; D012720:Severity of Illness Index