title: Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma.
abstract: OBJECTIVE
  The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[(18)F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole ((18)F-FRP170).
  
  
  METHODS
  Twelve patients with glioblastoma underwent (18)F-FRP170 PET before tumor resection. Mean standardized uptake value (SUV) and normalized SUV were calculated at regions within a tumor showing high (high-uptake area) and relatively low (low-uptake area) accumulations of (18)F-FRP170. In these areas, intratumoral oxygen pressure (tpO2) was measured using microelectrodes during tumor resection.
  
  
  RESULTS
  Mean tpO2 was significantly lower in the high-uptake area than in the low-uptake area. A significant negative correlation was evident between normalized SUV and tpO2 in the high-uptake area.
  
  
  CONCLUSIONS
  The present findings suggest that high accumulation on (18)F-FRP170 PET represents viable hypoxic tissues in glioblastoma.
authors.affiliation: Department of Neurosurgery, Iwate Medical University, Uchimaru 19-1, Morioka, 020-8505, Japan, tbeppu@iwate-med.ac.jp.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Beppu
authors.forename: Kazunori
authors.initials: K
authors.lastname: Terasaki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sasaki
authors.forename: Shunrou
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Hideki
authors.initials: H
authors.lastname: Matsuura
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Koichiro
authors.initials: K
authors.lastname: Sera
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yamada
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Uesugi
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sugai
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Kudo
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ehara
authors.forename: Ren
authors.initials: R
authors.lastname: Iwata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D015687:Cell Hypoxia; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000493:pharmacokinetics*; D010100:Oxygen / Q000378:metabolism*; D049268:Positron-Emission Tomography; D011312:Pressure
chemical_list: C501635:FRP-170; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009593:Nitroimidazoles; D019788:Fluorodeoxyglucose F18; D010100:Oxygen