title: A history of the development of Brucella vaccines.
abstract: Brucellosis is a worldwide zoonosis affecting animal and human health. In the last several decades, much research has been performed to develop safer Brucella vaccines to control the disease mainly in animals. Till now, no effective human vaccine is available. The aim of this paper is to review and discuss the importance of methodologies used to develop Brucella vaccines in pursuing this challenge.
authors.affiliation: Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Col. Sto. Tomás, 11340 México, DF, Mexico.
authors.forename: Eric Daniel
authors.initials: ED
authors.lastname: Avila-Calderón
authors.forename: Ahidé
authors.initials: A
authors.lastname: Lopez-Merino
authors.forename: Nammalwar
authors.initials: N
authors.lastname: Sriranganathan
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Boyle
authors.forename: Araceli
authors.initials: A
authors.lastname: Contreras-Rodríguez
mesh_terms: D000818:Animals; D002004:Brucella Vaccine / Q000266:history* / Q000276:immunology; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control; D060740:Disease Eradication; D049673:History, 20th Century; D006801:Humans; D022223:Vaccines, Subunit / Q000276:immunology
chemical_list: D002004:Brucella Vaccine; D022223:Vaccines, Subunit