title: [Serum levels of IL-10 and IL-35 in Yusho patients].
abstract: We thought that dioxin and dioxin-like compound receptor AhR expressed on the surface of regulatory T (Treg) cells and Th17 cells could regulate immunological functions in the Yusho patients. In the present study, we measured Treg cell related cytokines IL-10 and IL-35 in the Yusho patients. Serum levels of IL-10 were higher, but not significant (p = 0.06), and serum levels of IL-35 were increased (p = 0.006) in comparison with healthy controls. These results imply Treg cell activation in the Yusho patients.
authors.affiliation: Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Koike
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kuwatsuka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Utani
mesh_terms: D000368:Aged; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D011164:Porphyrias / Q000097:blood*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology
chemical_list: C508609:IL10 protein, human; D007378:Interleukins; C532417:interleukin-35, human; D016753:Interleukin-10