title: Microscopic polyangiitis secondary to silica exposure.
abstract: There is sufficient evidence of the capacity of silica to induce autoimmunity in patients with some type of genetic susceptibility. There are several autoimmune diseases related to this exposure (rheumatoid arthritis, Sjögren's syndrome, sarcoidosis, systemic sclerosis). Nodular silicosis (clinical expression of this exposure in lungs) generates apoptosis, inflammation, loss of tolerance and a respiratory burst. There is evidence that relates silica with induction of antineutrophil cytoplasmic antibodies, but, until it is better explained, the reports of systemic vasculitis secondary to silica exposure are inconclusive. We describe a case of a patient with a history of occupational exposure to silica who developed microscopic polyangiitis.
authors.affiliation: Medicina Interna, Universidad Pontificia Bolivariana, Medellín, Colombia.
authors.forename: Juliana
authors.initials: J
authors.lastname: Vega Miranda
authors.affiliation: Grupo de Reumatología. Hospital Pablo Tobón Uribe, Medellín, Colombia.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Pinto Peñaranda
authors.affiliation: Grupo de Reumatología. Hospital Pablo Tobón Uribe, Medellín, Colombia.
authors.forename: Javier Darío
authors.initials: JD
authors.lastname: Márquez Hernández
authors.affiliation: Grupo de Reumatología. Hospital Pablo Tobón Uribe, Medellín, Colombia; Facultad de Medicina, Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia. Electronic address: carjaivel@hotmail.com.
authors.forename: Carlos Jaime
authors.initials: CJ
authors.lastname: Velásquez Franco
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D055953:Microscopic Polyangiitis / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects*; D012822:Silicon Dioxide / Q000009:adverse effects*
chemical_list: D012822:Silicon Dioxide
keywords: Antibodies antineutrophil cytoplasmic; Anticuerpos anticitoplasma del neutrófilo; Autoimmunity; Autoinmunidad; Glomerulonefritis rápidamente progresiva con hemorragia pulmonar; Microscopic polyangiitis; Poliangiítis microscópica; Rapidly progressive glomerulonephritis with pulmonary hemorrhage; Silicosis