title: Oxidant and antioxidant status in children with subacute sclerosing panencephalitis.
abstract: We analyzed serum alpha-tocopherol, beta-carotene, retinol, and ascorbic acid levels and malondialdehyde and reduced glutathione concentrations on erythrocyte and cerebrospinal fluid in 30 patients with subacute sclerosing panencephalitis to evaluate oxidant and antioxidant status. Serum alpha-tocopherol, beta-carotene, retinol, ascorbic acid levels, and erythrocyte and cerebrospinal fluid reduced glutathione concentrations were decreased; however, erythrocyte and cerebrospinal fluid malondialdehyde levels were increased in the patients. Cerebrospinal fluid malondialdehyde levels were different between clinical stages of the disease (P < .05). Higher cerebrospinal fluid malondialdehyde level was associated with the more severe clinical stage. A positive correlation was found between cerebrospinal fluid malondialdehyde level and clinical stages (r = 0.42; P < .05) and between erythrocyte malondialdehyde level and clinical stages (r = 0.40; P < .05). Our findings showed presence of oxidative damage in subacute sclerosing panencephalitis and that antioxidants were increased as defense mechanisms of the organism against oxidative damage.
authors.affiliation: Meram Medical Faculty, Department of Pediatrics, Divisions of Pediatric Neurology and Pediatric Genetics, Necmettin Erbakan University, Meram, Konya, Turkey huseyincaksen@hotmail.com.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Caksen
authors.affiliation: Faculty of Medicine, Department of Pediatrics, Yüzüncü Yıl University, Van, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozkan
authors.affiliation: Faculty of Chemistry and Metallurgy, Department of Bioengineering, Division of Biochemistry, Yıldız Technical University, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cemek
authors.affiliation: Semiha Şakir Education and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Cemek
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000032:analysis*; D001205:Ascorbic Acid / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D005978:Glutathione / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000134:cerebrospinal fluid; D016877:Oxidants / Q000097:blood* / Q000134:cerebrospinal fluid*; D012720:Severity of Illness Index; D013344:Subacute Sclerosing Panencephalitis / Q000097:blood* / Q000134:cerebrospinal fluid*; D014801:Vitamin A / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D016877:Oxidants; D019207:beta Carotene; D014801:Vitamin A; D008315:Malondialdehyde; D005978:Glutathione; D024502:alpha-Tocopherol; D001205:Ascorbic Acid
keywords: antioxidant; oxidant; subacute sclerosing panencephalitis