title: The effects of different wavelength UV photofunctionalization on micro-arc oxidized titanium.
abstract: Many challenges exist in improving early osseointegration, one of the most critical factors in the long-term clinical success of dental implants. Recently, ultraviolet (UV) light-mediated photofunctionalization of titanium as a new potential surface treatment has aroused great interest. This study examines the bioactivity of titanium surfaces treated with UV light of different wavelengths and the underlying associated mechanism. Micro-arc oxidation (MAO) titanium samples were pretreated with UVA light (peak wavelength of 360 nm) or UVC light (peak wavelength of 250 nm) for up to 24 h. UVC treatment promoted the attachment, spread, proliferation and differentiation of MG-63 osteoblast-like cells on the titanium surface, as well as the capacity for apatite formation in simulated body fluid (SBF). These biological influences were not observed after UVA treatment, apart from a weaker effect on apatite formation. The enhanced bioactivity was substantially correlated with the amount of Ti-OH groups, which play an important role in improving the hydrophilicity, along with the removal of hydrocarbons on the titanium surface. Our results showed that both UVA and UVC irradiation altered the chemical properties of the titanium surface without sacrificing its excellent physical characteristics, suggesting that this technology has extensive potential applications and merits further investigation.
authors.affiliation: Center of Oral Implantology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Zehong
authors.initials: Z
authors.lastname: Guo
authors.forename: Mingdeng
authors.initials: M
authors.lastname: Rong
authors.forename: Xiangning
authors.initials: X
authors.lastname: Liu
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lai
authors.forename: Xianglong
authors.initials: X
authors.lastname: Ding
mesh_terms: D001031:Apatites / Q000737:chemistry / Q000528:radiation effects; D002454:Cell Differentiation / Q000528:radiation effects; D002460:Cell Line; D049109:Cell Proliferation / Q000528:radiation effects; D022001:Focal Adhesions; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D016348:Osseointegration / Q000528:radiation effects*; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology / Q000528:radiation effects; D010084:Oxidation-Reduction; D011485:Protein Binding; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D001031:Apatites; D014025:Titanium