title: Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy.
abstract: The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the "CIS only" condition. The study was based on the longitudinally followed Gothenburg 1950-1964 incidence cohort (n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained "CIS only". Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining "CIS only". Patients who had experienced no relapse during the first 25 years remained "CIS only" for the subsequent 25 years of follow-up.
authors.affiliation: Section of Clinical Neuroscience and Rehabilitation, University of Gothenburg, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Novakova
authors.forename: B
authors.initials: B
authors.lastname: Skoog
authors.forename: B
authors.initials: B
authors.lastname: Runmarker
authors.forename: S
authors.initials: S
authors.lastname: Ekholm
authors.forename: S
authors.initials: S
authors.lastname: Winblad
authors.forename: V
authors.initials: V
authors.lastname: Lisovskaja
authors.forename: O
authors.initials: O
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D003711:Demyelinating Diseases / Q000150:complications / Q000453:epidemiology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology; D011379:Prognosis; D012008:Recurrence; D055815:Young Adult
keywords: Clinically isolated syndrome; cohort; magnetic resonance imaging; multiple sclerosis; neuropsychology; optic neuritis