title: Nevus comedonicus: an updated review.
abstract: The intention of this review on nevus comedonicus (NC) is to update on clinical features, pathogenesis, and therapy. NC is a rare epidermal nevus type. It is part of the nevus comedonicus syndrome, a neurocutaneous disorder with ocular, skeletal, and central nervous symptoms. Recently, acne-related signaling pathways and somatic mutations of tyrosine kinase receptors have been identified and may play a role in NC pathogenesis. On preexistent NC secondary skin tumors can develop, which are often benign. Treatment options of NC include topical therapy, laser, and surgery.
authors.affiliation: Policlinic for Dermatology and Venerology, Saint Kliment Ohridski University, University Hospital Lozenetz, Sofia, Bulgaria.
authors.forename: Georgi
authors.initials: G
authors.lastname: Tchernev
authors.forename: Julian
authors.initials: J
authors.lastname: Ananiev
authors.forename: Kristina
authors.initials: K
authors.lastname: Semkova
authors.forename: Lyubomir A
authors.initials: LA
authors.lastname: Dourmishev
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Schönlebe
authors.forename: Uwe
authors.initials: U
authors.lastname: Wollina
keywords: Adnexal tumors of skin; Epidermal nevus syndrome; Nevus comedonicus; Rare skin disorders; Tyrosine kinase receptors