title: Functional and effective connectivity in subthalamic local field potential recordings of patients with Parkinson's disease.
abstract: In Parkinson's disease (PD) levodopa-associated changes in the power and long-range temporal correlations of beta oscillations have been demonstrated, yet the presence and modulation of genuine connectivity in local field potentials (LFP) recorded from the subthalamic nucleus (STN) remains an open question. The present study investigated LFP recorded bilaterally from the STN at wakeful rest in ten patients with PD after overnight withdrawal of levodopa (OFF) and after a single dose levodopa administration (ON). We utilized connectivity measures being insensitive to volume conduction (functional connectivity: non-zero imaginary part of coherency; effective connectivity: phase-slope index). We demonstrated the presence of neuronal interactions in the frequency range of 10-30 Hz in STN-LFP without a preferential directionality of interactions between different contacts along the electrode tracks. While the direction of neuronal interactions per se was preserved after levodopa administration, functional connectivity and the ventral-dorsal information flow were modulated by medication. The OFF-ON differences in functional connectivity were correlated with the levodopa-induced improvement in clinical Unified Parkinson's Disease Rating Scale scores. We hypothesize that regional neuronal interactions, as reflected in STN-LFP connectivity, might represent a basis for the intra-nuclear spatial specificity of deep brain stimulation. Moreover, our results suggest the potential use of volume conduction-insensitive measures of connectivity in STN-LFP as a marker of clinical motor symptoms in PD.
authors.affiliation: Neurophysics Group, Department of Neurology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany. Electronic address: friederike.hohlefeld@gmx.de.
authors.forename: F U
authors.initials: FU
authors.lastname: Hohlefeld
authors.forename: C
authors.initials: C
authors.lastname: Huchzermeyer
authors.forename: J
authors.initials: J
authors.lastname: Huebl
authors.forename: G-H
authors.initials: GH
authors.lastname: Schneider
authors.forename: G
authors.initials: G
authors.lastname: Nolte
authors.forename: C
authors.initials: C
authors.lastname: Brücke
authors.forename: T
authors.initials: T
authors.lastname: Schönecker
authors.forename: A A
authors.initials: AA
authors.lastname: Kühn
authors.forename: G
authors.initials: G
authors.lastname: Curio
authors.forename: V V
authors.initials: VV
authors.lastname: Nikulin
mesh_terms: D000368:Aged; D000465:Algorithms; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001611:Beta Rhythm; D003627:Data Interpretation, Statistical; D046690:Deep Brain Stimulation; D015259:Dopamine Agents / Q000627:therapeutic use; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000187:drug effects; D020531:Subthalamic Nucleus / Q000502:physiology*
chemical_list: D000978:Antiparkinson Agents; D015259:Dopamine Agents; D007980:Levodopa
keywords: COH; DBS; LFP; PD; PSI; PSI(sig); Parkinson’s disease; STN; UPDRS; Unified Parkinson’s Disease Rating Scale; averaged jackknife significance of iCOH; basal ganglia; coherence; coherency; deep brain stimulation; iCOH; iCOH(sig); iCOH(sigav); imaginary part of coherence; jackknife significance of PSI; jackknife significance of iCOH; levodopa; local field potentials; neuronal oscillations; phase–slope index; subthalamic nucleus