title: DNA in motion during double-strand break repair.
abstract: DNA organization and dynamics profoundly affect many biological processes such as gene regulation and DNA repair. In this review, we present the latest studies on DNA mobility in the context of DNA damage. Recent studies demonstrate that DNA mobility is dramatically increased in the presence of double-strand breaks (DSBs) in the yeast Saccharomyces cerevisiae. As a consequence, chromosomes explore a larger nuclear volume, facilitating homologous pairing but also increasing the rate of ectopic recombination. Increased DNA dynamics is dependent on several homologous recombination (HR) proteins and we are just beginning to understand how chromosome dynamics is regulated after DNA damage.
authors.affiliation: Institut de Biologie de l'Ecole Normale Supérieure (IBENS), CNRS UMR 8197, Ecole Normale Supérieure, 46, rue d'Ulm, 75005 Paris, France; Department of Genetics & Development, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Miné-Hattab
authors.forename: Rodney
authors.initials: R
authors.lastname: Rothstein
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D006801:Humans; D009068:Movement; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
chemical_list: D004247:DNA
keywords: DNA mobility; DNA repair; double-strand break repair; homologous recombination