title: Atroposelective [2+2+2] cycloadditions catalyzed by a rhodium(I)-chiral phosphate system.
abstract: Enantioselective cationic Rh(I)-catalyzed [2+2+2] cycloaddition reactions between diynes and isocyanates relying on the chiral anion strategy have been devised. In the presence of [Rh(cod)Cl]2, 1,4-bis(diphenylphosphino)butane, and the silver phosphate salt Ag(S)-TRIP as the unique source of chirality, axially chiral pyridones were isolated with ees up to 82%. This approach is novel in the field of chiral anion-mediated asymmetric catalysis since atroposelective transformations have so far remained unprecedented. It also proves to be complementary to the classical strategy based on chiral L-type ligands.
authors.affiliation: UPMC Univ Paris 06, UMR 7201 CNRS, Institut Parisien de Chimie Moléculaire, F-75005, Paris, France.
authors.forename: Mylène
authors.initials: M
authors.lastname: Augé
authors.forename: Marion
authors.initials: M
authors.lastname: Barbazanges
authors.forename: Anh Tuan
authors.initials: AT
authors.lastname: Tran
authors.forename: Antoine
authors.initials: A
authors.lastname: Simonneau
authors.forename: Paulin
authors.initials: P
authors.lastname: Elley
authors.forename: Hani
authors.initials: H
authors.lastname: Amouri
authors.forename: Corinne
authors.initials: C
authors.lastname: Aubert
authors.forename: Louis
authors.initials: L
authors.lastname: Fensterbank
authors.forename: Vincent
authors.initials: V
authors.lastname: Gandon
authors.forename: Max
authors.initials: M
authors.lastname: Malacria
authors.forename: Jamal
authors.initials: J
authors.lastname: Moussa
authors.forename: Cyril
authors.initials: C
authors.lastname: Ollivier