title: Effects of sevoflurane and desflurane on oxidative stress during general anesthesia for elective cesarean section.
abstract: BACKGROUND
  Anesthetic agents might considerably influence maternal-fetal oxidative stress and antioxidants during cesarean section (CS). The aim of this study was to investigate the effects of desflurane and sevoflurane on oxidative stress parameters both in mothers and newborns undergoing elective CS.
  
  
  METHODS
  Eighty ASA physical status I-II, term parturients undergoing elective CS under general anesthesia were randomized to desflurane (Group D) and sevoflurane (Group S) groups. Blood samples were collected from mothers before operation and postoperatively and umbilical artery samples were obtained at delivery. Total oxidant status (TOS), total antioxidant capacity (TAC) status, lipid hydroperoxide (LOOH), and free sulfhydryl (-SH) levels were measured and oxidative stress index was calculated. Secondary outcomes included maternal hemodynamics.
  
  
  RESULTS
  Preoperative LOOH, TOS, OSI, TAC, and -SH levels were similar among groups. Postoperative maternal serum LOOH, TOS, and OSI levels were significantly increased in Group D compared to Group S (p = 0.003, p = 0.005, p = 0.04; respectively). Postoperative umbilical artery LOOH, TOS, OSI levels were also significantly increased in Group D compared to Group S (p = 0.04, p = 0.02, p = 0.01; respectively). Postoperative TOS (p = 0.001, < 0.001 respectively) and OSI (p = 0.003, < 0.001 respectively) levels in both Group D and Group S were statistically significantly decreased compared to preoperative levels. Postoperative LOOH and -SH levels in Group S (p = 0.04, 0.029 respectively) were statistically significantly decreased compared to preoperative levels. There were no significant differences in TAC and -SH levels among groups (p = nonsignificant [n.s.]). Maternal perioperative mean blood pressure and heart rate were similar among groups (p = n.s.).
  
  
  CONCLUSIONS
  Oxidative stress indices might be modified with preferred anesthetic agent and sevoflurane showed more favorable effects than desflurane in view of oxidative stress.
authors.affiliation: Department of Anesthesiology and Reanimation, Harran University Medical Faculty, Yeniğehir Yerleğkesi, 63300 Sanliurfa, Turkey. sabanyalcin@yahoo.com
authors.forename: Saban
authors.initials: S
authors.lastname: Yalcin
authors.forename: Harun
authors.initials: H
authors.lastname: Aydoğan
authors.forename: Hasan Husnu
authors.initials: HH
authors.lastname: Yuce
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kucuk
authors.forename: Mahmut Alp
authors.initials: MA
authors.lastname: Karahan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Vural
authors.forename: Aysun
authors.initials: A
authors.lastname: Camuzcuoğlu
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000293:Adolescent; D000328:Adult; D018681:Anesthetics, General / Q000494:pharmacology; D018685:Anesthetics, Inhalation; D002585:Cesarean Section; D000077335:Desflurane; D017558:Elective Surgical Procedures; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy / Q000097:blood*; D017382:Reactive Oxygen Species / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D000077149:Sevoflurane; D055815:Young Adult
chemical_list: D018681:Anesthetics, General; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D017382:Reactive Oxygen Species; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane