title: Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis.
abstract: Phytochemical investigation of the seeds of Salacia longipes var. camerunensis led to the isolation of four sesquiterpenoid derivatives, salaterpene A (1) (1α,2β,8β-triacetoxy-6β,9β-dibenzoyloxy-4β-hydroxy-dihydro-β-agarofuran), salaterpene B (2) (1α,2β,8β-triacetoxy-9β-benzoyloxy-6β-cinnamoyloxy-4β-hydroxy-dihydro-β-agarofuran), salaterpene C (3) (1α,2β-diacetoxy-6β,9β-dibenzoyloxy-4β-hydroxy-dihydro-β-agarofuran) and salaterpene D (4) (2β-acetoxy-1α,6β-dibenzoyloxy-4β-hydroxy-9β-nicotinoyloxy-dihydro-β-agarofuran) together with two known compounds (5 and 6). The structures of the compounds were established by means of NMR spectroscopy. Compounds 1-4 and 6 were tested in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-resistant strain W2. All the tested compounds exhibited a moderate potency with IC50 below 2.7 μM.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon.
authors.forename: Brice M
authors.initials: BM
authors.lastname: Mba'ning
authors.forename: Bruno N
authors.initials: BN
authors.lastname: Lenta
authors.forename: Diderot T
authors.initials: DT
authors.lastname: Noungoué
authors.forename: Cyril
authors.initials: C
authors.lastname: Antheaume
authors.forename: Yanick F
authors.initials: YF
authors.lastname: Fongang
authors.forename: Silvère A
authors.initials: SA
authors.lastname: Ngouela
authors.forename: Fabrice F
authors.initials: FF
authors.lastname: Boyom
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenthal
authors.forename: Etienne
authors.initials: E
authors.lastname: Tsamo
authors.forename: Norbert
authors.initials: N
authors.lastname: Sewald
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D002163:Cameroon; D002738:Chloroquine / Q000494:pharmacology*; D060467:Disease Resistance / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects*; D049918:Salacia / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D012717:Sesquiterpenes; D002738:Chloroquine
keywords: Antiplasmodial activity; Celastraceae; Salacia longipes; Salaterpenes A–D; Sesquiterpenes