title: Enantioselective synthesis of anti homoallylic alcohols from terminal alkynes and aldehydes based on concomitant use of a cationic iridium complex and a chiral phosphoric acid.
abstract: We report a highly diastereo- and enantioselective synthesis of anti homoallylic alcohols from terminal alkynes via (E)-1-alkenylboronates based upon two catalytic reactions: a cationic iridium complex-catalyzed olefin transposition of (E)-1-alkenylboronates and a chiral phosphoric acid-catalyzed allylation reaction of aldehydes.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan. tmiura@sbchem.kyoto-u.ac.jp
authors.forename: Tomoya
authors.initials: T
authors.lastname: Miura
authors.forename: Yui
authors.initials: Y
authors.lastname: Nishida
authors.forename: Masao
authors.initials: M
authors.lastname: Morimoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Murakami