title: Oral application of bacterial lysate in infancy diminishes the prevalence of atopic dermatitis in children at risk for atopy.
abstract: Numerous interventions such as avoidance of food allergens, prolonged breast feeding and supplementation of pro-and/or prebiotics have been tried as primary prevention of atopic dermatitis. Recent data suggest that prevention of infantile eczema is possible in a subgroup of children by feeding bacterial lysates early in life. Bacterial lysates of Escherichia coli and Enterococcus faecalis were found to impair allergic immune responses in rats. An interventional trial in 606 infants at risk for atopy showed a reduction of atopic dermatitis at the end of the treatment phase (month 2 until month 7) of 50% in a subgroup of children with single heredity for atopy. This was even more pronounced in the group of children with paternal heredity for atopy. This effect was still seen at age 1 year. There was no effect on food sensitisation. In conclusion, an immune modulation in terms of prevention of atopic dermatitis in infancy if single atopic family history is present seems to be possible by feeding bacterial lysates early in life.
authors.affiliation: Department of Paediatric Pneumology and Immunology, Charité Medical University, Augustenburger Platz 1, 13353 Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Lau
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001688:Biological Products / Q000008:administration & dosage*; D001691:Biological Therapy / Q000379:methods*; D002457:Cell Extracts / Q000008:administration & dosage* / Q000276:immunology; D002648:Child; D002986:Clinical Trials as Topic; D003876:Dermatitis, Atopic / Q000517:prevention & control*; D004195:Disease Models, Animal; D013293:Enterococcus faecalis / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D051381:Rats; D016896:Treatment Outcome; D000095983:Bacterial Lysates
chemical_list: D001688:Biological Products; D002457:Cell Extracts; D007155:Immunologic Factors; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates
keywords: Enterococcus spp.; Escherichia coli; atopic dermatitis; children; immune modulation