title: First total synthesis of (-)-sinularianin B.
abstract: The first enantioselective total synthesis of (-)-sinularianin B, a structurally unique sesquiterpenoid isolated from the Formosan soft coral Sinularia sp., has been accomplished in 16 steps with 39.5% overall yield. Key transformations include formation of a cyclopentane possessing a tertiary hydroxy group via a tandem intermolecular-intramolecular alkylation involving a 5-endo cyclization.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ota
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyaoka
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D012717:Sesquiterpenes; C587402:sinularianin B