title: Control of cell cycle transcription during G1 and S phases.
abstract: The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition. CDK activation initiates a positive feedback loop that further increases CDK activity, and this commits the cell to division by inducing genome-wide transcriptional changes. G1-S transcripts encode proteins that regulate downstream cell cycle events. Recent work is beginning to reveal the complex molecular mechanisms that control the temporal order of transcriptional activation and inactivation, determine distinct functional subgroups of genes and link cell cycle-dependent transcription to DNA replication stress in yeast and mammals.
authors.affiliation: Medical Research Council (MRC) Laboratory for Molecular Cell Biology, University College London, London, UK. c.bertoli@ucl.ac.uk
authors.forename: Cosetta
authors.initials: C
authors.lastname: Bertoli
authors.forename: Jan M
authors.initials: JM
authors.lastname: Skotheim
authors.forename: Robertus A M
authors.initials: RA
authors.lastname: de Bruin
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics* / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics*; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D016193:G1 Phase / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D016196:S Phase / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*; D015003:Yeasts / Q000235:genetics / Q000502:physiology
chemical_list: D018797:Cell Cycle Proteins; D018844:Cyclin-Dependent Kinases