title: Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves of Croton campestris A. St.-Hill in Rodents.
abstract: Croton campestris A. St.-Hill., popularly known as "velame do campo," is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic extract of C. campestris leaves (HELCC) was assessed for its antiulcerogenic effect in gastric lesion models and effect on intestinal motility in mice, and possible mechanisms of action were examined. HELCC showed significant gastroprotective action in all models of gastric ulcer evaluated; the results suggest that this action probably involves the nitric oxide pathway. HELCC did not show alteration of intestinal motility in mice. It was also found that C. campestris represents a promising natural source with important biological potential, justifying some of its uses in folk medicine.
authors.affiliation: Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
authors.forename: Francisco E B
authors.initials: FE
authors.lastname: Júnior
authors.forename: Dayanne R
authors.initials: DR
authors.lastname: de Oliveira
authors.forename: Elizângela B
authors.initials: EB
authors.lastname: Bento
authors.forename: Laura H I
authors.initials: LH
authors.lastname: Leite
authors.forename: Daniele O
authors.initials: DO
authors.lastname: Souza
authors.forename: Ana Luiza A
authors.initials: AL
authors.lastname: Siebra
authors.forename: Renata S
authors.initials: RS
authors.lastname: Sampaio
authors.forename: Anita O P B
authors.initials: AO
authors.lastname: Martins
authors.forename: Andreza G B
authors.initials: AG
authors.lastname: Ramos
authors.forename: Saulo R
authors.initials: SR
authors.lastname: Tintino
authors.forename: Luiz J
authors.initials: LJ
authors.lastname: Lacerda-Neto
authors.forename: Patricia R L
authors.initials: PR
authors.lastname: Figueiredo
authors.forename: Larissa R
authors.initials: LR
authors.lastname: Oliveira
authors.forename: Cristina K S
authors.initials: CK
authors.lastname: Rodrigues
authors.forename: Valterlúcio S
authors.initials: VS
authors.lastname: Sales
authors.forename: Francisco R S D N
authors.initials: FR
authors.lastname: Figueiredo
authors.forename: Emmily P
authors.initials: EP
authors.lastname: Nascimento
authors.forename: Alefe B
authors.initials: AB
authors.lastname: Monteiro
authors.forename: Erika N
authors.initials: EN
authors.lastname: Amaro
authors.forename: José G M
authors.initials: JG
authors.lastname: Costa
authors.forename: Henrique
authors.initials: H
authors.lastname: Douglas Melo Coutinho
authors.forename: Irwin R A
authors.initials: IR
authors.lastname: de Menezes
authors.forename: Marta R
authors.initials: MR
authors.lastname: Kerntopf