title: Whole apple extracts increase lifespan, healthspan and resistance to stress inCaenorhabditis elegans.
abstract: Regular consumption of fruits and vegetables is associated with reduced risk of age-related functional decline and chronic diseases such as cancer and cardiovascular disease. These effects are primarily attributed to phytochemicals, plant compounds with a wide range of biological activities and health benefits. Apples, the top contributor of fruit phenolics in American diets, have high antioxidant, antiproliferative and chemopreventive activityin vitroandin vivo.However, little is known about their effects on aging. The objectives of this study were to determine the effects of whole apple phytochemical extracts on lifespan, healthspan and resistance to various stressesin vivousingC. elegansas a model. The mean and maximum lifespan of animals treated with 2.5, 5 and 10 mg/ml whole apple extracts increased significantly in a dose-dependent manner by up to 39 and 25%, respectively. Healthspan also significantly improved as indicated by improved motility and reduced lipofuscin accumulation. Animals pre-treated with whole apple extracts were more resistant to stresses such as heat, UV radiation, paraquat-induced oxidative stress, and pathogenic infection, suggesting that cellular defense and immune system functions also improved. Our findings indicate that, inC. elegans, whole apple extracts slow aging, extend lifespan, improve healthspan, and enhance resistance to stress.
authors.affiliation: Institute of Comparative and Environmental Toxicology, Cornell University, Ithaca, NY.
authors.forename: Elena M
authors.initials: EM
authors.lastname: Vayndorf
authors.forename: Siu Sylvia
authors.initials: SS
authors.lastname: Lee
authors.forename: Rui Hai
authors.initials: RH
authors.lastname: Liu
keywords: Aging; Antioxidant; Apple; Caenorhabditis elegans; Healthspan; Phytochemical