title: Tissue-engineered mandibular bone reconstruction for continuity defects: a systematic approach to the literature.
abstract: BACKGROUND
  Despite significant surgical advances over the last decades, segmental mandibular bone repair remains a challenge. In light of this, tissue engineering might offer a next step in the evolution of mandibular reconstruction.
  
  
  OBJECTIVE
  The purpose of the present report was to (1) systematically review preclinical in vivo as well as clinical literature regarding bone tissue engineering for mandibular continuity defects, and (2) to analyze their effectiveness.
  
  
  METHODS
  An electronic search in the databases of the National Library of Medicine and ISI Web of Knowledge was carried out. Only publications in English were considered, and the search was broadened to animals and humans. Furthermore, the reference lists of related review articles and publications selected for inclusion in this review were systematically screened. Results of histology data and amount of bone bridging were chosen as primary outcome variables. However, for human reports, clinical radiographic evidence was accepted for defined primary outcome variable. The biomechanical properties, scaffold degradation, and clinical wound healing were selected as co-outcome variables.
  
  
  RESULTS
  The electronic search in the databases of the National Library of Medicine and ISI Web of Knowledge resulted in the identification of 6727 and 5017 titles, respectively. Thereafter, title assessment and hand search resulted in 128 abstracts, 101 full-text articles, and 29 scientific papers reporting on animal experiments as well as 11 papers presenting human data on the subject of tissue-engineered reconstruction of mandibular continuity defects that could be included in the present review.
  
  
  CONCLUSIONS
  It was concluded that (1) published preclinical in vivo as well as clinical data are limited, and (2) tissue-engineered approaches demonstrate some clinical potential as an alternative to autogenous bone grafting.
authors.affiliation: 1 Department of Oral and Maxillofacial Surgery, National Dental Centre Singapore , Singapore, Singapore .
authors.forename: Nattharee
authors.initials: N
authors.lastname: Chanchareonsook
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Junker
authors.forename: Leenaporn
authors.initials: L
authors.lastname: Jongpaiboonkit
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D000818:Animals; D016025:Bone Transplantation; D001842:Bone and Bones / Q000166:cytology*; D006801:Humans; D063175:Mandibular Reconstruction / Q000379:methods*; D019651:Plastic Surgery Procedures; D023822:Tissue Engineering; D014945:Wound Healing