title: Early recognition of septic shock in children.
abstract: In the developed countries septic shock has a favorable outcome for the majority of previously healthy children but also in children with comorbidities if all available medical resources were used. However, septic shock remains a rare disease in children, and caregivers might not always recognize it at early stages. The resulting delay of appropriate treatment prevents lower mortality rates. The current review gives an overview of the pathophysiology of septic shock and the early clinical signs as well as new and future diagnostic approaches such as "point-of-care" laboratory tests for an early diagnosis.
authors.affiliation: Department of Pediatrics 1, University Hospital Essen, Germany. christian.dohna-schwake@uk-essen.de
authors.forename: C
authors.initials: C
authors.lastname: Dohna-Schwake
authors.forename: U
authors.initials: U
authors.lastname: Felderhoff-Müser
mesh_terms: D015415:Biomarkers / Q000097:blood; D015687:Cell Hypoxia / Q000502:physiology; D002648:Child; D019411:Clinical Laboratory Techniques; D042241:Early Diagnosis; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007362:Intensive Care Units; D019344:Lactic Acid / Q000097:blood; D008833:Microcirculation / Q000502:physiology; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D019095:Point-of-Care Systems; D011379:Prognosis; D012772:Shock, Septic / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D019344:Lactic Acid; D010100:Oxygen