title: [Clinical analyses of perinuclear antineutrophil cytoplasmic antibody associated hypertrophic pachymeningitis].
abstract: OBJECTIVE
  To explore the clinical characteristics, diagnosis, treatment and prognosis of perinuclear antineutrophil cytoplasmic antibody (p-ANCA) associated hypertrophic pachymeningitis.
  
  
  METHODS
  A retrospective study was performed for 6 inpatients with p-ANCA associated hypertrophic pachymeningitis at our hospital from 2005 to 2012.
  
  
  RESULTS
  There were 3 males and 3 females with an age range of 52 - 68 years. The main clinical manifestations included headache and multiple cranial neuropathies. Erythrocyte sedimentation rate, C-reactive protein, titer of myeloperoxidase (MPO)-ANCA and protein in cerebrospinal fluid were uniformly elevated in all 6 patients during active phase while cytoplasmic(c)-ANCA was all negative. Head magnetic resonance imaging (MRI) enhancement scan had a high diagnostic sensitivity. Different parts of dura were all thickened and obviously enhanced. Glucocorticoid was uniformly effective. During the follow-up period, 2 cases relapsed and received immunosuppressive agents.
  
  
  CONCLUSIONS
  The disease should be considered in elderly patients with headache, cranial nerve injury and positive p-ANCA. And head MRI enhancement scan is helpful for diagnosis.
authors.affiliation: Department of Neurology, General Hospital, Tianjin Medical University, Tianjin 300052, China. zhaopeng7824@126.com
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Ben-shu
authors.initials: BS
authors.lastname: Zhang
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008581:Meningitis / Q000097:blood / Q000175:diagnosis*; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic