title: GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation.
abstract: A tri(ethylene glycol)-containing lactide analogue was synthesized via thiol-ene chemistry between a bi-functional triethylene glycol and allyl lactide. Subsequent tin-octoate-catalyzed ring-opening polymerization yielded well-defined poly(lactide)-graft-poly(ethylene glycol) copolymers with molecular weights of 6000 g/mol and polydispersity indices of 1.6. The tri(ethylene glycol) chains along the copolymers contain azide termini that are capable of 'click'-type postpolymerization functionalization. The utility of this strategy was demonstrated via successful Staudinger ligation to install the Gly-Arg-Gly-Asp-Ser (GRGDS) peptide.
authors.affiliation: Molecular Design Institute and Department of Chemistry, New York University, New York, NY 10003, United States.
authors.forename: Dorothee E
authors.initials: DE
authors.lastname: Borchmann
authors.forename: Niels Ten
authors.initials: NT
authors.lastname: Brummelhuis
authors.forename: Marcus
authors.initials: M
authors.lastname: Weck