title: A patient with nephrotic-range proteinuria and focal global glomerulosclerosis.
abstract: A young male is evaluated for nephrotic-range proteinuria, hypercalciuria, and an elevated serum creatinine. A renal biopsy is performed and shows focal global glomerulosclerosis. The absence of nephrotic syndrome suggest that glomerulosclerosis was a secondary process. Further analysis of the proteinuria showed it to be due mainly to low-molecular weight proteins. The case illustrates the crucial role of electron microscopy as well as evaluation of the identity of the proteinuria that accompanies a biopsy finding of focal and global or focal and segmental glomerulosclerosis.
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota.
authors.forename: Fernando C
authors.initials: FC
authors.lastname: Fervenza
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D018118:Chloride Channels / Q000235:genetics; D003404:Creatinine / Q000097:blood; D057973:Dent Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D016368:Frameshift Mutation; D020022:Genetic Predisposition to Disease; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D053565:Hypercalciuria / Q000209:etiology; D008297:Male; D009401:Nephrosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D010641:Phenotype; D011237:Predictive Value of Tests; D011507:Proteinuria / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C097503:CLC-5 chloride channel; D018118:Chloride Channels; D049993:Sodium Chloride Symporter Inhibitors; D003404:Creatinine