title: Whole genome sequencing of an unusual serotype of Shiga toxin-producing Escherichia coli.
abstract: Shiga toxin-producing Escherichia coli serotype O117:K1:H7 is a cause of persistent diarrhea in travelers to tropical locations. Whole genome sequencing identified genetic mechanisms involved in the pathoadaptive phenotype. Sequencing also identified toxin and putative adherence genes flanked by sequences indicating horizontal gene transfer from Shigella dysenteriae and Salmonella spp., respectively.
authors.affiliation: Health Protection Agency, London, UK.
authors.forename: Tim
authors.initials: T
authors.lastname: Dallman
authors.forename: Lisa
authors.initials: L
authors.lastname: Cross
authors.forename: Chloe
authors.initials: C
authors.lastname: Bishop
authors.forename: Neil
authors.initials: N
authors.lastname: Perry
authors.forename: Bente
authors.initials: B
authors.lastname: Olesen
authors.forename: Kathie A
authors.initials: KA
authors.lastname: Grant
authors.forename: Claire
authors.initials: C
authors.lastname: Jenkins
mesh_terms: D016680:Genome, Bacterial; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D016013:Likelihood Functions; D058885:Multilocus Sequence Typing; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D012703:Serotyping; D054323:Shiga-Toxigenic Escherichia coli / Q000145:classification / Q000235:genetics*
keywords: Escherichia coli; O117:K1:H7; Shiga toxin–producing Escherichia coli; bacteria; gene transfer; pathogenicity; serotype; whole genome sequencing