title: Characterization of antibiotic-loaded alginate-OSA starch microbeads produced by ionotropic pregelation.
abstract: The aim of this study was to characterize the penicillin-loaded microbeads composed of alginate and octenyl succinic anhydride (OSA) starch prepared by ionotropic pregelation with calcium chloride and to evaluate their in vitro drug delivery profile. The beads were characterized by size, scanning electron microscopy (SEM), zeta potential, swelling behavior, and degree of erosion. Also, the possible interaction between penicillin and biopolymers was investigated by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), and Fourier transform infrared (FTIR) analysis. The SEM micrograph results indicated a homogeneous drug distribution in the matrix. Also, based on thermal analyses (TGA/DSC), interactions were detected between microbead components. Although FTIR spectra of penicillin-loaded microbeads did not reveal the formation of new chemical entities, they confirmed the chemical drug stability. XRD patterns showed that the incorporated crystalline structure of penicillin did not significantly alter the primarily amorphous polymeric network. In addition, the results confirmed a prolonged penicillin delivery system profile. These results imply that alginate and OSA starch beads can be used as a suitable controlled-release carrier for penicillin.
authors.affiliation: Escola de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. gizelecf@yahoo.com.br
authors.forename: Gizele Cardoso
authors.initials: GC
authors.lastname: Fontes
authors.forename: Verônica Maria Araújo
authors.initials: VM
authors.lastname: Calado
authors.forename: Alexandre Malta
authors.initials: AM
authors.lastname: Rossi
authors.forename: Maria Helena Miguez
authors.initials: MH
authors.lastname: da Rocha-Leão
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002152:Calorimetry, Differential Scanning; D005782:Gels / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D010400:Penicillin G / Q000494:pharmacology; D011208:Powders; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry / Q000648:ultrastructure; D055672:Static Electricity; D013499:Surface Properties; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D005782:Gels; D006603:Hexuronic Acids; D011208:Powders; C551966:octenyl succinic anhydride-modified starch; D020723:Glucuronic Acid; D013213:Starch; D010400:Penicillin G