title: Epithelial neutral amino acid transporters: lessons from mouse models.
abstract: OBJECTIVE
  Epithelial neutral amino acid transporters have been identified at the molecular level in recent years. Mouse models have now established the crucial role of these transporters for systemic amino acid homeostasis. This review summarizes recent progress in this field.
  
  
  RESULTS
  Epithelial neutral amino acid transporters play an important role in the homeostasis of neutral amino acid levels in the body. They are important for the maintenance of body weight and muscle mass and serve as fuels. They also serve a role in providing nutrients to epithelial cells. Changes of plasma amino acid levels are not necessarily correlated to the amino acids appearing in the urine; changes in organ amino acid metabolism need to be taken into account.
  
  
  CONCLUSIONS
  Genetic deletion of neutral amino acid transporters provides insight into their role in protein nutrition and homeostasis.
authors.affiliation: Research School of Biology, Australian National University, Canberra, Australia. Stefan.broeer@anu.edu.au
authors.forename: Stefan
authors.initials: S
authors.lastname: Bröer
mesh_terms: D027182:Amino Acid Transport System y+ / Q000235:genetics / Q000378:metabolism; D026921:Amino Acid Transport Systems, Neutral / Q000235:genetics / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000085962:Angiotensin-Converting Enzyme 2; D000818:Animals; D004848:Epithelium / Q000378:metabolism*; D027301:Fusion Regulatory Protein 1, Light Chains / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D051379:Mice / Q000502:physiology*; D018345:Mice, Knockout; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000378:metabolism
chemical_list: D027182:Amino Acid Transport System y+; D026921:Amino Acid Transport Systems, Neutral; D000596:Amino Acids; D027301:Fusion Regulatory Protein 1, Light Chains; D008562:Membrane Glycoproteins; C505021:SLC6A19 protein, mouse; C518286:SLC7A8 protein, mouse; C509612:Slc16a10 protein, mouse; C504407:Tmem27 protein, mouse; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; C000705328:Ace2 protein, mouse; D000085962:Angiotensin-Converting Enzyme 2