title: Nuclear imprisonment: viral strategies to arrest host mRNA nuclear export.
abstract: Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.
authors.affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Sharon.Kuss@utsouthwestern.edu
authors.forename: Sharon K
authors.initials: SK
authors.lastname: Kuss
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Mata
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Beatriz M A
authors.initials: BM
authors.lastname: Fontoura
mesh_terms: D021581:Active Transport, Cell Nucleus; D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D009980:Influenza A virus / Q000276:immunology / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D018116:Vesiculovirus / Q000276:immunology / Q000502:physiology*; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D014764:Viral Proteins