title: The role of adipocytokines on depressive symptoms of patients with chronic kidney disease.
abstract: OBJECTIVE
  The aim of this study is to evaluate depression and anxiety scores among chronic kidney disease (CKD) patients and to search the changes of serum concentrations of adipokines with respect to emotional disturbances of CKD patients.
  
  
  METHODS
  150 patients recruited into this cross-sectional analytic study. Study groups were control, hemodialysis, predialysis, peritoneal dialysis and kidney transplantation groups. Fasting morning serum leptin, ghrelin, acylated ghrelin, neuropeptide Y, adiponectin, resistin levels of all of the groups were measured using ELISA (Sandwich) method. A screening interview based on the Structured Clinical Interview for DSM-IV and self-report scales (The Beck Depression [BDI] and The Beck Anxiety Inventory [BAI] and Brief Symptom Inventory [BSI] which is self report scales) were administered and conducted by a trained interviewer.
  
  
  RESULTS
  BDI scores were significantly higher in hemodialysis and predialysis groups compared to control group (p = 0.009). Somatization sub scores of BSI were significantly higher in hemodialysis and peritoneal dialysis groups compared to control group (p = 0.041). Also positive symptom distress index scores of BSI were significantly higher in hemodialysis and transplantation groups compared to control group (p = 0.047). BDI score were significantly negatively correlated with duration of education (r = -0.165, p = 0.045), positively correlated with presence of protein energy wasting (r = 0.198, p = 0.016), and resistin levels (r = 0.233, p = 0.004).
  
  
  CONCLUSIONS
  CKD patients had higher BDI, BSI-somatization, BSI-positive symptom distress index scores compared to control group. High serum resistin levels, presence of protein energy wasting might have a role in development of depressive disorders of patients with chronic kidney disease.
authors.affiliation: Department of Nephrology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. kkaynar@yahoo.com
authors.forename: Kubra
authors.initials: K
authors.lastname: Kaynar
authors.forename: Evrim
authors.initials: E
authors.lastname: Ozkorumak
authors.forename: Birgul Vanizor
authors.initials: BV
authors.lastname: Kural
authors.forename: Sukru
authors.initials: S
authors.lastname: Ulusoy
authors.forename: Muammer
authors.initials: M
authors.lastname: Cansiz
authors.forename: Buket
authors.initials: B
authors.lastname: Akcan
authors.forename: Nuray
authors.initials: N
authors.lastname: Mısır
authors.forename: Ilkay
authors.initials: I
authors.lastname: Keles
authors.forename: Esra
authors.initials: E
authors.lastname: Koc
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000097:blood* / Q000150:complications; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000097:blood* / Q000150:complications; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000523:psychology* / Q000628:therapy
chemical_list: D054392:Adipokines; D054439:Ghrelin