title: Clinical studies support a role for trem-like transcript-1 during the progression of sepsis.
abstract: Sepsis is a multi-factorial disease that kills an estimated 1,400 people a day worldwide. The Triggering Receptor Expressed in Myeloid (TREM) cells Like Transcript (TLT)-1 is a platelet receptor expressed on activated platelets. Translational studies of TLT-1 suggest that TLT-1 affects hemostatic and immunological parameters that lead to the formation of disseminated intravascular coagulation (DIC). Evaluation of mice suffering from endotoxic shock shows a dramatic increase of soluble TLT-1 (sTLT-1) in their blood. Accordingly, when we evaluated the blood of septic patients we find increased levels of sTLT-1 that correlate with the presence of DIC in humans. Based on current data we hypothesize that TLT-1 plays an important role in maintaining vascular integrity during sepsis; perhaps by modulation of both the immune and hemostatic systems, and that TLT-1 makes an attractive target not only for better understanding of sepsis, but also as a point of therapeutic intervention as well.
authors.affiliation: Department of Internal Medicine, Luis Arnau Hospital Regional, Bayamon PR 00959.
authors.forename: Omar
authors.initials: O
authors.lastname: Esponda
authors.forename: Jessica
authors.initials: J
authors.lastname: Morales
authors.forename: Alexandra
authors.initials: A
authors.lastname: Aguilar
authors.forename: Michael
authors.initials: M
authors.lastname: Gomez
authors.forename: A Valance
authors.initials: AV
authors.lastname: Washington
mesh_terms: D000818:Animals; D018450:Disease Progression; D051379:Mice; D011971:Receptors, Immunologic / Q000502:physiology*; D018805:Sepsis / Q000209:etiology*
chemical_list: D011971:Receptors, Immunologic; C471763:Treml1 protein, mouse