title: GNPs-CS/KGM as hemostatic first aid wound dressing with antibiotic effect: in vitro and in vivo study.
abstract: Ideal wound dressing materials should create a good healing environment, with immediate hemostatic effects and antimicrobial activity. In this study, chitosan/konjac glucomannan (CS/KGM) films embedded with gentamicin-loaded poly(dex-GMA/AAc) nanoparticles (giving GNP-CS/KGM films) were prepared as novel wound dressings. The results revealed that the modified CS/KGM films could be used as effective wound dressings and had significant hemostatic effects. With their microporous structure, the films could effectively absorb water from blood and trap blood cells. The gentamicinloaded poly(dex-GMA/AAc) nanoparticles (GNPs) also further promoted blood clotting, with their favorable water uptake capacity. Thus, the GNP-CS/KGM films had wound healing and synergistic effects that helped to stop bleeding from injuries, and also showed good antibiotic abilities by addition of gentamicin to the NPs. These GNPCS/KGM films can be considered as promising novel biodegradable and biocompatible wound dressings with hemostatic capabilities and antibiotic effects for treatment of external bleeding injuries.
authors.affiliation: Department of Pharmaceutical Chemistry and Analysis, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Chong
authors.initials: C
authors.lastname: Cheng
authors.forename: Youbei
authors.initials: Y
authors.lastname: Qiao
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.forename: Bo
authors.initials: B
authors.lastname: Ren
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D003911:Dextrans / Q000737:chemistry; D005839:Gentamicins / Q000737:chemistry / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D003911:Dextrans; D005839:Gentamicins; D011108:Polymers