title: Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.
abstract: Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.
authors.affiliation: Vietnam National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, Hanoi, Vietnam.
authors.forename: Phuong Thien
authors.initials: PT
authors.lastname: Thuong
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.forename: Nguyen Minh
authors.initials: NM
authors.lastname: Khoi
authors.forename: Hoang Thi My
authors.initials: HT
authors.lastname: Nhung
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Chinh
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Quy
authors.forename: Tae Su
authors.initials: TS
authors.lastname: Jang
authors.forename: Minkyun
authors.initials: M
authors.lastname: Na
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D003603:Cytotoxins / Q000302:isolation & purification* / Q000494:pharmacology; D004285:Dogs; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D061986:MCF-7 Cells; D061985:Madin Darby Canine Kidney Cells; D051379:Mice; D026323:Myristica; D012639:Seeds; D047368:Tumor Burden / Q000187:drug effects* / Q000502:physiology; D014744:Vietnam; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D017705:Lignans