title: Use of intrathecal baclofen for treatment of severe spasticity in selected patients with motor neuron disease.
abstract: OBJECTIVE
  To assess the safety and efficacy of intrathecal baclofen (ITB) therapy for severe spasticity in patients with upper-motor neuron predominant motor neuron disease (U-MND).
  
  
  METHODS
  A total of 44 patients with U-MND were referred for discussion of ITB therapy. Baseline and outcomes data were extracted on 35 patients from a clinical spasticity registry at a tertiary referral center. Patients choosing to initiate ITB (n = 20) were compared with those choosing conservative therapy (n = 15).
  
  
  RESULTS
  At baseline, lower average pain score in the non-ITB group was the only significant difference between the 2 groups. A significant reduction in pain scores, Modified Ashworth Scale (MAS), Spasm Frequency Scale, and requirement for oral spasticity medications was observed within the ITB group at early and late follow-up. Within the non-ITB group, there was a significant increase in MAS scores between baseline and late follow-up. A statistically significant difference favoring the ITB group was observed for change in MAS score (P < .0001), Numerical Rating Scale pain score (P = .04), dose of oral baclofen (P = .002) and tizanidine (P = .003), and number of oral medications for spasticity (P = .002). There was no difference between the 2 groups in the progression of hip flexor weakness or in the proportion of patients who became nonambulatory.
  
  
  CONCLUSIONS
  Our findings suggest that ITB can effectively reduce spasticity and related symptoms without compromising function in selected patients with U-MND.
authors.affiliation: 1Cleveland Clinic, Ohio, USA.
authors.forename: Francois
authors.initials: F
authors.lastname: Bethoux
authors.forename: Nicholas
authors.initials: N
authors.lastname: Boulis
authors.forename: Shearwood
authors.initials: S
authors.lastname: McClelland
authors.forename: Mary Alissa
authors.initials: MA
authors.lastname: Willis
authors.forename: Mariam
authors.initials: M
authors.lastname: Hussain
authors.forename: Andre
authors.initials: A
authors.lastname: Machado
authors.forename: Lydia
authors.initials: L
authors.lastname: Mychkovsky
authors.forename: Darlene
authors.initials: D
authors.lastname: Stough
authors.forename: Matt
authors.initials: M
authors.lastname: Sutliff
authors.forename: Erik P
authors.initials: EP
authors.lastname: Pioro
mesh_terms: D001418:Baclofen / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000188:drug therapy*; D009128:Muscle Spasticity / Q000188:drug therapy*; D010147:Pain Measurement
chemical_list: D001418:Baclofen
keywords: intrathecal baclofen; motor neuron disease; spasticity