title: Sub-micronic capsules based on gelatin and poly(maleic anhydride-alt-vinyl acetate) obtained by interfacial condensation with potential biomedical applications.
abstract: New sub-micronic capsules based on a copolymer of maleic anhydride-alt-vinyl acetate and a natural polymer (gelatin) using an interfacial condensation method were obtained. Sub-micronic capsules were characterized by Fourier Transform infrared spectroscopy (FTIR), dynamic light scattering (DLS) method, zeta-potential, scanning electron microscopy (SEM) and atomic force microscopy (AFM). The thermal properties were investigated by thermogravimetric analysis (TGA). According to some parameters of the synthesis reaction (polymer weight ratio, acetone/water ratio, surfactant concentration), the mean diameter of the sub-micronic capsules can be tuned from 200 to 760 nm. The sub-micronic capsules show a higher agglomeration tendency as the amount of gelatin in their composition increases. The swelling capacity in aqueous solutions is dependent on the composition and size of the sub-micronic capsules, decreasing with their diameter and gelatin composition. The drug loading and release capacity was studied using Penicillin G (sodium salt) (PG), and it has been proved that it is influenced by the sub-micronic capsules morphology induced by preparation parameters. Encapsulation and controlled release of small molecule were successfully carried out, demonstrating the potential biomedical applications of these new easily obtained sub-micronic capsules.
authors.affiliation: Faculty of Chemical Engineering and Environmental Protection, Department of Natural and Synthetic Polymers, Gheorghe Asachi Technical University of Iasi, Professor Dr Docent Dimitrie Mangeron Avenue, 73, 700050 Iasi, Romania.
authors.forename: Delia Mihaela
authors.initials: DM
authors.lastname: Iurea
authors.forename: Cătălina Anişoara
authors.initials: CA
authors.lastname: Peptu
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Chailan
authors.forename: Pascal
authors.initials: P
authors.lastname: Carriere
authors.forename: Marcel
authors.initials: M
authors.lastname: Popa
mesh_terms: D002214:Capsules; D005780:Gelatin / Q000737:chemistry*; D008299:Maleic Anhydrides / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D017550:Spectroscopy, Fourier Transform Infrared; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D002214:Capsules; D008299:Maleic Anhydrides; D014753:Vinyl Compounds; D005780:Gelatin; C011566:vinyl acetate