title: Significant weight loss and rapid resolution of diabetes and dyslipidemia during short-term follow-up after laparoscopic sleeve gastrectomy.
abstract: BACKGROUND
  Bariatric surgery has been established as the best option of treatment for morbid obesity. Recently, laparoscopic sleeve gastrectomy (SG) has become very popular because of good postoperative weight loss and low morbidity. The aim of this study was to report our single-center experience with SG regarding feasibility, morbidity, and outcome.
  
  
  METHODS
  From January 2006 to December 2011, 93 patients (68 female) with a median age of 46 years underwent laparoscopic SG at our department. Thirteen patients had a history of gastric banding with insufficient weight loss or band-related complications. Clinical outcome and laboratory findings were analyzed.
  
  
  RESULTS
  The mean preoperative and postoperative body mass index (BMI) was 44.1 ± 6.9 and 33.4 ± 6.8 kg/m(2), respectively (p < 0.001). The mean excessive body weight loss after a median follow-up of 11.9 months was 55.7 % ± 24.9 %. Three bleedings, two staple line leakages, and a deep wound infection required conversion to laparotomy (n = 1), reoperation (n = 4), or endoscopic stent implantation (n = 2). Resolution of diabetes and dyslipidemia was seen in 85 and 50 % of patients, respectively. Blood test results of HbA1c, cholesterols, triglycerides, and leptin showed significant postoperative improvement.
  
  
  CONCLUSIONS
  Laparoscopic SG represents a feasible bariatric procedure with good short-term weight loss, low morbidity rate, and efficient resolution of diabetes and dyslipidemia, especially in patients with lower BMI. The significant decrease of leptin necessitates further studies to understand the ambiguous role of leptin in bariatric surgery.
authors.affiliation: Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Innsbruck Medical University, Anichstr. 35, 6020, Innsbruck, Austria, alexander.perathoner@i-med.ac.at.
authors.forename: A
authors.initials: A
authors.lastname: Perathoner
authors.forename: A
authors.initials: A
authors.lastname: Weißenbacher
authors.forename: R
authors.initials: R
authors.lastname: Sucher
authors.forename: E
authors.initials: E
authors.lastname: Laimer
authors.forename: J
authors.initials: J
authors.lastname: Pratschke
authors.forename: R
authors.initials: R
authors.lastname: Mittermair
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002784:Cholesterol / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000601:surgery; D050171:Dyslipidemias / Q000378:metabolism* / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D015391:Gastroplasty; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D010535:Laparoscopy; D020738:Leptin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism / Q000601:surgery*; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D016896:Treatment Outcome; D014280:Triglycerides / Q000378:metabolism; D015431:Weight Loss
chemical_list: D002784:Cholesterol; D006442:Glycated Hemoglobin; D020738:Leptin; D014280:Triglycerides; C517652:hemoglobin A1c protein, human