title: Target-induced charge reduction of aptamers for visual detection of lysozyme based on positively charged gold nanoparticles.
abstract: Positively charged gold nanoparticles ((+)AuNPs) are electrostatically adsorbed on the negatively charged aptamers and the solution displays a blue color due to the aggregation of the (+)AuNPs, while the binding of the target lysozyme with the aptamers reduces the charge of the aptamers, which stabilizes the (+)AuNPs and the (+)AuNPs solution remains red in color.
authors.affiliation: Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Su
authors.forename: Wenjiao
authors.initials: W
authors.lastname: Zhou
authors.forename: Yun
authors.initials: Y
authors.lastname: Xiang
authors.forename: Ruo
authors.initials: R
authors.lastname: Yuan
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Chai
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D003124:Colorimetry; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009113:Muramidase / Q000032:analysis*; D010084:Oxidation-Reduction; D055672:Static Electricity
chemical_list: D052157:Aptamers, Nucleotide; D006046:Gold; D009113:Muramidase