title: Wound coverage technologies in burn care: novel techniques.
abstract: Improvements in burn wound care have vastly decreased morbidity and mortality in severely burned patients. Development of new therapeutic approaches to increase wound repair has the potential to reduce infection, graft rejection, and hypertrophic scarring. The incorporation of tissue-engineering techniques, along with the use of exogenous proteins, genes, or stem cells to enhance wound healing, heralds new treatment regimens based on the modification of already existing biological activity. Refinements to surgical techniques have enabled the creation of protocols for full facial transplantation. With new technologies and advances such as these, care of the severely burned will undergo massive changes over the next decade. This review centers on new developments that have recently shown great promise in the investigational arena.
authors.affiliation: From the *University of Toronto; †Department of Surgery, Division of Plastic Surgery, ‡Department of Immunology, and §Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre; ‖Sunnybrook Research Institute; ¶Department of Surgery, Sealy Center for Molecular Medicine, and the Institute for Translational Science, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston; and #Department of Plastic and Reconstructive Surgery, Hannover Medical School, Germany.
authors.forename: Marc G
authors.initials: MG
authors.lastname: Jeschke
authors.forename: Celeste C
authors.initials: CC
authors.lastname: Finnerty
authors.forename: Shahriar
authors.initials: S
authors.lastname: Shahrokhi
authors.forename: Ludwik K
authors.initials: LK
authors.lastname: Branski
authors.forename: Manuel
authors.initials: M
authors.lastname: Dibildox
mesh_terms: D000818:Animals; D001458:Bandages / Q000639:trends*; D002056:Burns / Q000628:therapy*; D002921:Cicatrix / Q000517:prevention & control; D003428:Cross Infection / Q000517:prevention & control; D054445:Facial Transplantation / Q000639:trends; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D017592:Skin Care / Q000639:trends*; D016038:Skin Transplantation / Q000639:trends; D017768:Skin, Artificial / Q000639:trends; D033581:Stem Cell Transplantation / Q000639:trends; D023822:Tissue Engineering / Q000639:trends*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D015718:Fibrin Tissue Adhesive