title: [Family-based association study of dopaminergic genes polymorphisms and EAS temperamental traits].
abstract: OBJECTIVE
  The aim of the present study was to identify relations between several polymorphisms in dopamine genes (DRD2, DRD3, DRD4, SNAP-25, ANKKland DATI) and temperamental traits distinguished in the EAS theory. In this study the family-based method was used.
  
  
  METHODS
  The study was run on 149 biological families with one or two children aged 3-12. Temperamental data were obtained using Buss and Plomin EAS-C Temperament Questionnaire.
  
  
  RESULTS
  Significant associations between two SNPs in the SNAP-25 gene (rs363039 and rs363050) and shyness was found. Significant relationships of this trait with haplotypes in DAT1 and SNAP-25 genes was also identified.
  
  
  CONCLUSIONS
  The data collected suggest that variability in dopamine genes may have impact on the development of temperamental shyness, which is recognized as a fear of strangers.
authors.affiliation: Wydzial Psychologii UW Katedra Psychologii R6znic Indywidualnych Kierownik.
authors.forename: Wojciech Ł
authors.initials: WŁ
authors.lastname: Dragan
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Oniszczenko
authors.forename: Piotr M
authors.initials: PM
authors.lastname: Czerski
authors.forename: Monika
authors.initials: M
authors.lastname: Dmitrzak-Weglarz
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D004298:Dopamine / Q000235:genetics*; D005195:Family Relations; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000235:genetics*; D011044:Poland; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics*; D013694:Temperament
chemical_list: D050825:Synaptosomal-Associated Protein 25; D004298:Dopamine