title: Macronutrient intake and type 2 diabetes risk in middle-aged Australian women. Results from the Australian Longitudinal Study on Women's Health.
abstract: OBJECTIVE
  To investigate the association between macronutrient intake and type 2 diabetes risk in middle-aged Australian women.
  
  
  METHODS
  A prospective cohort study, with 6 years (2002-2007) of follow up. Dietary intake was assessed with a validated FFQ. Relative risks with 95 % confidence intervals were used to examine risk associations.
  
  
  METHODS
  Australian Longitudinal Study on Women's Health, Australia.
  
  
  METHODS
  Australian women (n 8370) from the Australian Longitudinal Study on Women's Health aged 45-50 years and free of type 2 diabetes at baseline.
  
  
  RESULTS
  After 6 years of follow-up, 311 women developed type 2 diabetes. After adjusting for sociodemographic, lifestyle and other dietary risk factors, MUFA, total n-3 PUFA, α-linolenic acid and total n-6 PUFA intakes were positively associated with the incidence of type 2 diabetes. The relative risks for type 2 diabetes for the highest compared with the lowest quintiles were 1·64 (95 % CI 1·06, 2·54), P = 0·04 for MUFA; 1·55 (95 % CI 1·03, 2·32), P = 0·01 for n-3 PUFA; 1·84 (95 % CI 1·25, 2·71), P < 0·01 for α-linolenic acid; and 1·60 (95 % CI 1·03, 2·48), P = 0·04 for n-6 PUFA. Other dietary macronutrients were not significantly associated with diabetes risk.
  
  
  CONCLUSIONS
  The data indicate that consumption of MUFA, n-3 PUFA and n-6 PUFA may influence the risk of developing type 2 diabetes in women.
authors.affiliation: 1Nutrition and Dietetics,School of Health Sciences,Faculty of Health,University of Newcastle,Callaghan,New South Wales,Australia.
authors.forename: Amani
authors.initials: A
authors.lastname: Alhazmi
authors.affiliation: 3Schools of Mathematical and Physical Sciences,Faculty of Science and Information Technology,University of Newcastle,Callaghan,New South Wales,Australia.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Stojanovski
authors.affiliation: 4Centre for Clinical Epidemiology & Biostatistics,Faculty of Health,University of Newcastle,Callaghan,New South Wales,Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: McEvoy
authors.affiliation: 5School of Biomedical Sciences and Pharmacy,305C Medical Sciences Building,Faculty of Health,University of Newcastle,Callaghan,NSW 2308,Australia.
authors.forename: Manohar L
authors.initials: ML
authors.lastname: Garg
mesh_terms: D001315:Australia; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D004032:Diet / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects*; D005229:Fatty Acids, Monounsaturated / Q000009:adverse effects*; D015525:Fatty Acids, Omega-3 / Q000009:adverse effects*; D043371:Fatty Acids, Omega-6 / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D016387:Women's Health
chemical_list: D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6