title: Serum uric acid levels and endothelial dysfunction in patients with autosomal dominant polycystic kidney disease.
abstract: OBJECTIVE
  Patients with autosomal dominant polycystic kidney disease (ADPKD) exhibit endothelial dysfunction (ED) despite normal levels of renal function. Hyperuricemia occurs in these patients and has been postulated to affect ED through the generation of oxidative stress. We therefore investigated the prevalence of ED and its association with serum uric acid levels in early-stage ADPKD.
  
  
  METHODS
  A cross-sectional design was used for the assessment of prevalent patients with early-stage (normal renal function) ADPKD (n = 91) from two academic medical centers. ED was assessed using ischemia-induced forearm flow-mediated vasodilation (FMD). Serum uric acid levels were evaluated using an Olympus AU2700 autoanalyzer.
  
  
  RESULTS
  ADPKD patients with higher serum uric acid levels had a higher asymmetric dimethylarginine (ADMA) level (1.19 ± 0.2 vs. 1.47 ± 0.3, p < 0.001) and lower FMD rates (8.1 ± 1.3 vs. 6.8 ± 0.7, p < 0.001). In multiple regression analysis for predictors of cohort FMD, uric acid (β = -0.32, p < 0.001), ADMA (β = -0.36, p < 0.001), high-sensitivity C reactive protein (CRP; β = -0.32, p < 0.001) and estimated glomerular filtration rate (eGFR; β = 0.33, p < 0.001) all predicted FMD.
  
  
  CONCLUSIONS
  In early-stage ADPKD patients, uric acid levels, serum ADMA and eGFR all independently predict ED in a similar manner. Future studies are needed to investigate the causes of elevated serum uric acid, ADMA and CRP in these patients.
authors.affiliation: Department of Nephrology, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Kocyigit
authors.forename: Mahmut Ilker
authors.initials: MI
authors.lastname: Yilmaz
authors.forename: Ozcan
authors.initials: O
authors.lastname: Orscelik
authors.forename: Murat Hayri
authors.initials: MH
authors.lastname: Sipahioglu
authors.forename: Aydin
authors.initials: A
authors.lastname: Unal
authors.forename: Eray
authors.initials: E
authors.lastname: Eroglu
authors.forename: Nihat
authors.initials: N
authors.lastname: Kalay
authors.forename: Bulent
authors.initials: B
authors.lastname: Tokgoz
authors.forename: Jonas
authors.initials: J
authors.lastname: Axelsson
authors.forename: Oktay
authors.initials: O
authors.lastname: Oymak
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005919:Glomerular Filtration Rate; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D016891:Polycystic Kidney, Autosomal Dominant / Q000097:blood / Q000503:physiopathology*; D014527:Uric Acid / Q000097:blood*; D014664:Vasodilation
chemical_list: D014527:Uric Acid; C018524:N,N-dimethylarginine; D002097:C-Reactive Protein; D001120:Arginine