title: Automated aorta segmentation in low-dose chest CT images.
abstract: OBJECTIVE
  Abnormalities of aortic surface and aortic diameter can be related to cardiovascular disease and aortic aneurysm. Computer-based aortic segmentation and measurement may aid physicians in related disease diagnosis. This paper presents a fully automated algorithm for aorta segmentation in low-dose non-contrast CT images.
  
  
  METHODS
  The original non-contrast CT scan images as well as their pre-computed anatomy label maps are used to locate the aorta and identify its surface. First a seed point is located inside the aortic lumen. Then, a cylindrical model is progressively fitted to the 3D image space to track the aorta centerline. Finally, the aortic surface is located based on image intensity information. This algorithm has been trained and tested on 359 low-dose non-contrast CT images from VIA-ELCAP and LIDC public image databases. Twenty images were used for training to obtain the optimal set of parameters, while the remaining images were used for testing. The segmentation result has been evaluated both qualitatively and quantitatively. Sixty representative testing images were used to establish a partial ground truth by manual marking on several axial image slices.
  
  
  RESULTS
  Compared to ground truth marking, the segmentation result had a mean Dice Similarity Coefficient of 0.933 (maximum 0.963 and minimum 0.907). The average boundary distance between manual segmentation and automatic segmentation was 1.39 mm with a maximum of 1.79 mm and a minimum of 0.83 mm.
  
  
  CONCLUSIONS
  Both qualitative and quantitative evaluations have shown that the presented algorithm is able to accurately segment the aorta in low-dose non-contrast CT images.
authors.affiliation: School of Electrical and Computer Engineering, Cornell University, Ithaca, New York, USA, yx269@cornell.edu.
authors.forename: Yiting
authors.initials: Y
authors.lastname: Xie
authors.forename: Jennifer
authors.initials: J
authors.lastname: Padgett
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Biancardi
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Reeves
mesh_terms: D000465:Algorithms; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008962:Models, Theoretical; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*