title: Chemotherapeutic options for colorectal cancer patients with cardiovascular diseases.
abstract: The high incidence of cardiovascular disease and colorectal cancer in the world's population means that these two conditions may coexist in the same patient. In addition fluoropyrimidines, backbone for the treatment of colorectal cancer in both early stage and advanced disease, have a well-characterized cardio-toxicity, which limits their use in patients with heart disease and limits their reintroduction in those patients who have shown this toxicity. For the treatment of this, increasing proportion of patients is now possible to consider fluoropyrimidines-free chemotherapy regimens that are examined in this work, with the attempt to provide a possible treatment algorithm for various situations encountered in clinical practice.
authors.affiliation: UO di Oncologia, Fondazione Poliambulanza, Via Bissolati 57, 25124, Brescia, Italy. zanib@numerica.it.
authors.forename: Brunella
authors.initials: B
authors.lastname: Di Biasi
authors.forename: Tiziana
authors.initials: T
authors.lastname: Prochilo
authors.forename: Tony
authors.initials: T
authors.lastname: Sabatini
authors.forename: Alberto
authors.initials: A
authors.lastname: Zaniboni
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D014943:Global Health; D006801:Humans; D015994:Incidence; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil