title: [A retrospective study of UFT and oral leucovorin combination adjuvant chemotherapy for patients over 76 years old with stage III colon cancer].
abstract: OBJECTIVE
  To perform a retrospective analysis of UFT and oral leucovorin combination adjuvant chemotherapy for Stage III colon cancer patients over 76 years old, in order to evaluate both treatment efficacy and toxicity.
  
  
  METHODS
  Between 2002 and 2011, 333 Stage III colon cancer patients had surgery performed in our institute, and we studied 25 of them on our chemotherapy regimen.
  
  
  RESULTS
  Patients'median age was 78 years old, with 12 men and 13 women. Of all the patients, 19 had Stage IIIa and 6 had Stage IIIb. The 3-year disease-free survival rates for Stage III and Stage IIIa patients were 65. 1% and 83. 1%, respectively, and the 3-year overall survival rate for Stage III was 79. 9%. With regard to toxicity, liver function disorder was observed in 8% of the patients, being the adverse event that occurred the most, but there was no Grade 3 or 4 toxicity.
  
  
  CONCLUSIONS
  UFT and oral leucovorin combination adjuvant chemotherapy for Stage III colon cancer patients over 76 years showed a good response, especially for Stage III a.
authors.affiliation: Dept. of Surgery, Toranomon Hospital.
authors.forename: Kenji
authors.initials: K
authors.lastname: Tomizawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hanaoka
authors.forename: Shigeo
authors.initials: S
authors.lastname: Toda
authors.forename: Jin
authors.initials: J
authors.lastname: Moriyama
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Matoba
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kuroyanagi
authors.forename: Masaji
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Harushi
authors.initials: H
authors.lastname: Udagawa
authors.forename: Goro
authors.initials: G
authors.lastname: Watanabe
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D017326:Clinical Trials, Phase III as Topic; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D009367:Neoplasm Staging; D012189:Retrospective Studies; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D005641:Tegafur; D014498:Uracil; D002955:Leucovorin