title: Performance comparison between the mycobacteria growth indicator tube system and Löwenstein-Jensen medium in the routine detection of Mycobacterium tuberculosis at public health care facilities in Rio de Janeiro, Brazil: preliminary results of a pragmatic clinical trial.
abstract: In view of the fact that the World Health Organization has recommended the use of the mycobacteria growth indicator tube (MGIT) 960 system for the diagnosis of tuberculosis and that there is as yet no evidence regarding the clinical impact of its use in health care systems, we conducted a pragmatic clinical trial to evaluate the clinical performance and cost-effectiveness of the use of MGIT 960 at two health care facilities in the city of Rio de Janeiro, Brazil, where the incidence of tuberculosis is high. Here, we summarize the methodology and preliminary results of the trial. (ISRCTN.org Identifier: ISRCTN79888843 [http://isrctn.org/]) In view of the fact that the World Health Organization has recommended the use of the mycobacteria growth indicator tube (MGIT) 960 system for the diagnosis of tuberculosis and that there is as yet no evidence regarding the clinical impact of its use in health care systems, we conducted a pragmatic clinical trial to evaluate the clinical performance and cost-effectiveness of the use of MGIT 960 at two health care facilities in the city of Rio de Janeiro, Brazil, where the incidence of tuberculosis is high. Here, we summarize the methodology and preliminary results of the trial. (ISRCTN.org Identifier: ISRCTN79888843 [http://isrctn.org/]).
authors.affiliation: Federal University of Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Instituto de Doenças do Tórax, Rio de Janeiro, Brazil.
authors.forename: Adriana da Silva Rezende
authors.initials: Ada S
authors.lastname: Moreira
authors.forename: Gisele
authors.initials: G
authors.lastname: Huf
authors.forename: Maria Armanda
authors.initials: MA
authors.lastname: Vieira
authors.forename: Leila
authors.initials: L
authors.lastname: Fonseca
authors.forename: Monica
authors.initials: M
authors.lastname: Ricks
authors.forename: Afrânio Lineu
authors.initials: AL
authors.lastname: Kritski
mesh_terms: D001938:Brazil; D003470:Culture Media; D003955:Diagnostic Tests, Routine / Q000379:methods*; D006268:Health Facilities; D006801:Humans; D008828:Microbiological Techniques / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000254:growth & development*; D011634:Public Health; D017150:Public Sector; D014376:Tuberculosis / Q000175:diagnosis*
chemical_list: D003470:Culture Media