title: Silver-decorated orthorhombic nanotubes of lithium vanadium oxide: an impeder of bacterial growth and biofilm.
abstract: Reoccurrence of infectious diseases and ability of pathogens to resist antibacterial action has raised enormous challenges which may possibly be confronted by nanotechnology routes. In the present study, uniformly embedded silver nanoparticles in orthorhombic nanotubes of lithium vanadium oxide (LiV2O5/Ag) were explored as an impeder of bacterial growth and biofilm. The LiV2O5/Ag nanocomposites have impeded growth of Gram-positive Bacillus subtilis NCIM 2063 and Gram-negative Escherichia coli NCIM 2931 at 60 to 120 μg/mL. It also impeded the biofilm in Pseudomonas aeruginosa NCIM 2948 at 12.5 to 25 μg/mL. Impedance in the growth and biofilm occurs primarily by direct action of the nanocomposites on the cell surfaces of test organisms as revealed by surface perturbation in scanning electron microscopy. As the metabolic growth and biofilm formation phenomena of pathogens play a central role in progression of pathogenesis, LiV2O5/Ag nanocomposite-based approach is likely to curb the menace of reoccurrence of infectious diseases. Thus, LiV2O5/Ag nanocomposites can be viewed as a promising candidate in biofabrication of biomedical materials.
authors.affiliation: Centre For Materials For Electronics Technology, Off Pashan Road, Pune, India.
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Diggikar
authors.forename: Rajendra H
authors.initials: RH
authors.lastname: Patil
authors.forename: Sheetal B
authors.initials: SB
authors.lastname: Kale
authors.forename: Dipalee K
authors.initials: DK
authors.lastname: Thombre
authors.forename: Wasudeo N
authors.initials: WN
authors.lastname: Gade
authors.forename: Milind V
authors.initials: MV
authors.lastname: Kulkarni
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Kale
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D018441:Biofilms / Q000187:drug effects*; D004337:Drug Carriers / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D008094:Lithium / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D043942:Nanotubes / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D014639:Vanadium / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D010087:Oxides; D014639:Vanadium; D012834:Silver; D008094:Lithium