title: Pathway analysis detect potential mechanism for familial combined hyperlipidemia.
abstract: BACKGROUND
  Familial combined hyperlipidemia (FCHL) is the most commonly inherited hyperlipidemia in men. It constitutes a substantial risk factor for atherosclerosis patients.
  
  
  OBJECTIVE
  To delineating the potential mechanism of FCHL by bioinformatics tools.
  
  
  METHODS
  In this study, Protein-Protein Interaction (PPI) network was constructed to identify the potential functional proteins and their interactive relationships in familial combined hyperlipidemia.
  
  
  RESULTS
  Our results showed that androgen receptor (AR) might play an important role in familial combined hyperlipidemia by interaction with TGIF1, NR3C1, KLK2, etc. Some pathways were also identified, such as Hedgehog signaling pathway, Phosphatidylinositol signaling system, and Long-term depression, which were all demonstrated participating in lipid metabolism in previous experiments.
  
  
  CONCLUSIONS
  Although lack of direct evidence, by PPI network construction it proved AR is a key factor in FCHL, and also demonstrated that PPI network construction is an alternative avenue for FCHL analysis.
authors.affiliation: Department of Orthopedics, Feng Xian Center Hospital, Shanghai, China. xuefengdr01@gmail.com
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.forename: F
authors.initials: F
authors.lastname: Xue
authors.forename: L Z
authors.initials: LZ
authors.lastname: Liu
authors.forename: Z H
authors.initials: ZH
authors.lastname: He
mesh_terms: D000465:Algorithms; D030541:Databases, Genetic; D015870:Gene Expression; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000235:genetics / Q000503:physiopathology*; D046228:Microarray Analysis; D015398:Signal Transduction / Q000502:physiology