title: Antioxidant and anti-inflammatory activities of barettin.
abstract: In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in a lipid peroxidation cell assay. A de-brominated synthetic analogue of barettin did not show the same activity in the antioxidant cell assay, indicating that bromine is important for cellular activity. Barettin was also able to inhibit the secretion of the inflammatory cytokines IL-1β and TNFα from LPS-stimulated THP-1 cells. This combination of anti-inflammatory and antioxidant activities could indicate that barettin has an atheroprotective effect and may therefore be an interesting product to prevent development of atherosclerosis.
authors.affiliation: MabCent-SFI, University of Tromsø, Breivika N-9037 Tromsø, Norway. karianne.lind@uit.no
authors.forename: Karianne F
authors.initials: KF
authors.lastname: Lind
authors.forename: Espen
authors.initials: E
authors.lastname: Hansen
authors.forename: Bjarne
authors.initials: B
authors.lastname: Østerud
authors.forename: Karl-Erik
authors.initials: KE
authors.lastname: Eilertsen
authors.forename: Annette
authors.initials: A
authors.lastname: Bayer
authors.forename: Magnus
authors.initials: M
authors.lastname: Engqvist
authors.forename: Kinga
authors.initials: K
authors.lastname: Leszczak
authors.forename: Trond Ø
authors.initials: TØ
authors.lastname: Jørgensen
authors.forename: Jeanette H
authors.initials: JH
authors.lastname: Andersen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001685:Biological Factors / Q000737:chemistry / Q000494:pharmacology; D001966:Bromine / Q000378:metabolism; D045744:Cell Line, Tumor; D047231:Geodia / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism; D008386:Marine Biology; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001685:Biological Factors; D053583:Interleukin-1beta; D010456:Peptides, Cyclic; D014409:Tumor Necrosis Factor-alpha; C484472:barettin; D001966:Bromine