title: Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition.
abstract: A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein-protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their target protein.
authors.affiliation: Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Korea.
authors.forename: Boram
authors.initials: B
authors.lastname: Kim
authors.forename: Sung-ju
authors.initials: SJ
authors.lastname: Choi
authors.forename: So-hee
authors.initials: SH
authors.lastname: Han
authors.forename: Kang-Yell
authors.initials: KY
authors.lastname: Choi
authors.forename: Yong-beom
authors.initials: YB
authors.lastname: Lim
mesh_terms: D002942:Circular Dichroism; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary; D013499:Surface Properties; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry
chemical_list: D010455:Peptides; D016159:Tumor Suppressor Protein p53; D006046:Gold