title: Association of vitamin D receptor gene polymorphisms and Parkinson's disease in Hungarians.
abstract: Vitamin D receptor (VDR) gene encodes a transcription factor that influences calcium homeostasis and immunoregulation, and may play a role in neurological disorders including Parkinson's disease (PD). The investigations of the association between VDR and PD in different populations revealed various results. In a present study 100 PD patients and 109 healthy controls from the Hungarian population were genotyped for four polymorphic sites (BsmI, ApaI, FokI and TaqI) in the VDR gene. The polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Our results demonstrate an association between the FokI C allele and PD; the frequency of the C allele was significantly higher in PD patients than in controls, suggesting that this polymorphism may have a role in the development of PD in these patients.
authors.affiliation: Department of Neurology, University of Szeged, Semmelweis u. 6., H-6725 Szeged, Hungary.
authors.forename: Rita
authors.initials: R
authors.lastname: Török
authors.forename: Nora
authors.initials: N
authors.lastname: Török
authors.forename: Levente
authors.initials: L
authors.lastname: Szalardy
authors.forename: Imola
authors.initials: I
authors.lastname: Plangar
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Szolnoki
authors.forename: Ferenc
authors.initials: F
authors.lastname: Somogyvari
authors.forename: Laszlo
authors.initials: L
authors.lastname: Vecsei
authors.forename: Peter
authors.initials: P
authors.lastname: Klivenyi
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D006814:Hungary / Q000208:ethnology; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol
keywords: FokI; Parkinson's disease; Polymorphism; Vitamin D receptor