title: [Pathological complete response in a case of advanced esophageal cancer invading aorta treated by preoperative chemotherapy with docetaxel and cisplatin plus 5-FU].
abstract: The patient was a 64-year-old man, diagnosed as cStage IVa esophageal cancer invading the aorta with lymph node metastasis. He received combination chemotherapy with docetaxel/cisplatin/5-FU(DFP therapy). After one course, CT and endoscopic examination showed remarkable reduction of the primary lesion and lymph node metastasis. We performed subtotal esophagectomy and gastric tube reconstruction by the retroposterior mediastinum route. The pathological specimen evidenced fibrosis and infiltration of inflammatory cells on almost all layers, but showed no viable malignant cells in the middle thoracic esophagus. Therefore, the pathological effect was judged as Grade 3(pCR). This case suggested that DFP combination chemotherapy may prove to be a useful treatment for advanced esophageal cancer with invasion to other organs.
authors.affiliation: Dept. of Thoracic Endocrine Surgery and Oncology, Tokushima University Hospital, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishino
authors.forename: Yota
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Masami
authors.initials: M
authors.lastname: Morimoto
authors.forename: Takako
authors.initials: T
authors.lastname: Furukawa
authors.forename: Masakazu
authors.initials: M
authors.lastname: Goto
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Furukita
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takechi
authors.forename: Junichi
authors.initials: J
authors.lastname: Seike
authors.forename: Akira
authors.initials: A
authors.lastname: Tangoku
authors.forename: Haruo
authors.initials: H
authors.lastname: Fujiwara
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001011:Aorta / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil