title: The course of uveitis in pregnancy and postpartum.
abstract: OBJECTIVE
  To examine the course of non-infectious uveitis during pregnancy.
  
  
  METHODS
  This is a retrospective case series. The medical records of 47 subjects with a previous history of non-infectious uveitis pre-dating their pregnancy were reviewed. Uveitis activity during the periods 1 year before pregnancy, during pregnancy and 1 year postpartum, were recorded. Information on patient demographics, type of uveitis, medication use, sex of child and breastfeeding status were also collected. The main outcome measures were the events of flare-ups during the prepregnancy, pregnancy and postpartum periods.
  
  
  RESULTS
  The rate of flare-up was 1.188 per person year prior to pregnancy, 0.540 per person year during pregnancy and 0.972 per person year in postpartum (p<0.001 for comparison between prepregnancy and pregnancy; p=0.009 for comparison between pregnancy and postpartum). Rates of flare-up only began to decrease in the second trimester. After delivery, rates of flare-up rebounded and within 6 months postpartum, flare-up rates were not significantly different from prepregnancy levels (p=0.306). Even so, 40% of subjects were found to have remained inactive within 1 year postpartum.
  
  
  CONCLUSIONS
  Uveitis activity decreased by mid-pregnancy, but returned to prepregnancy levels within 6 months postpartum. These findings may be used to adjust uveitis management during pregnancy and the postpartum period.
authors.affiliation: Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, , Victoria, Australia.
authors.forename: Nathalie P Y
authors.initials: NP
authors.lastname: Chiam
authors.forename: Anthony J H
authors.initials: AJ
authors.lastname: Hall
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Stawell
authors.forename: Lucy
authors.initials: L
authors.lastname: Busija
authors.forename: Lyndell L P
authors.initials: LL
authors.lastname: Lim
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors; D014605:Uveitis / Q000209:etiology / Q000503:physiopathology*
keywords: Immunology; Inflammation