title: Resistant metastatic penile carcinoma and response to biochemotherapy with paclitaxel and epidermal growth factor receptor monoclonal antibody, nimotuzumab.
abstract: Carcinoma penis is one of the common malignancies in developing world especially among rural population. Multimodality treatment with surgery, radiation and chemotherapy for advanced penile carcinoma with groin nodal metastasis is crucial to optimise the outcome. Cisplatin, fluorouracil, methotrexate, vinorelbine, bleomycin and paclitaxel are the common chemotherapeutic agents used along with local therapy. Paucity of data to show superiority of one chemotherapeutic regime over another and only modest response to any combination chemotherapy. Progression of disease after surgery, radiation and chemotherapy is associated with poor outcome and quality of life. Nimotuzumab, Anti EGFR monoclonal antibody, along with paclitaxel in our case of resistant metastatic penile carcinoma has shown good symptomatic palliation and clinical response.
authors.affiliation: Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: Avinash
authors.initials: A
authors.lastname: Pandey
authors.forename: Vanita
authors.initials: V
authors.lastname: Noronha
authors.forename: Amit
authors.initials: A
authors.lastname: Joshi
authors.forename: Hemant
authors.initials: H
authors.lastname: Tongaonkar
authors.forename: Ganesh
authors.initials: G
authors.lastname: Bakshi
authors.forename: Kumar
authors.initials: K
authors.lastname: Prabhash
keywords: Biochemotherapy; metastatic penile carcinoma; nimotuzumab