title: A simple model for assessment of anti-toxin antibodies.
abstract: The toxins associated with infectious diseases are potential targets for inhibitors which have the potential for prophylactic or therapeutic use. Many antibodies have been generated for this purpose, and the objective of this study was to develop a simple mathematical model that may be used to evaluate the potential protective effect of antibodies. This model was used to evaluate the contributions of antibody affinity and concentration to reducing antibody-receptor complex formation and internalization. The model also enables prediction of the antibody kinetic constants and concentration required to provide a specified degree of protection. We hope that this model, once validated experimentally, will be a useful tool for in vitro selection of potentially protective antibodies for progression to in vivo evaluation.
authors.affiliation: HPP Division, Defence Science and Technology Organisation, Fishermans Bend, VIC 3207, Australia. alex.skvortsov@dsto.defence.gov.au
authors.forename: Alex
authors.initials: A
authors.lastname: Skvortsov
authors.forename: Peter
authors.initials: P
authors.lastname: Gray
mesh_terms: D000906:Antibodies / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003198:Computer Simulation; D004705:Endocytosis; D007700:Kinetics; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D011956:Receptors, Cell Surface / Q000378:metabolism; D014118:Toxins, Biological / Q000276:immunology*
chemical_list: D000906:Antibodies; D011956:Receptors, Cell Surface; D014118:Toxins, Biological