title: Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: priorities of the Westhafen Intercontinental Group.
abstract: More than 20% of allogeneic hematopoietic cell transplantations (HCTs) are performed in children and adolescents at a large number of relatively small centers. Unlike adults, at least one-third of HCTs in children are performed for rare, nonmalignant indications. Clinical trials to improve HCT outcomes in children have been limited by small numbers and these pediatric-specific features. The need for a larger number of pediatric HCT centers to participate in trials has led to the involvement of international collaborative groups. Representatives of the Pediatric Blood and Marrow Transplant Consortium, European Group for Blood and Marrow Transplantation's Pediatric Working Group, International Berlin-Frankfurt-Munster (iBFm) Stem Cell Transplantation Committee, and Children's Oncology Group's Hematopoietic Stem Cell Transplantation Discipline Committee met on October 3, 2012, in Frankfurt, Germany to develop a consensus on the highest priorities in pediatric HCT. In addition, it explored the creation of an international consortium to develop studies focused on HCT in children and adolescents. This meeting led to the creation of an international HCT network, dubbed the Westhafen Intercontinental Group, to develop worldwide priorities and strategies to address pediatric HCT issues. This review outlines the priorities of need as identified by this consensus group.
authors.affiliation: Pediatric Hematology/Oncology/BMT, British Columbia Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Rudolph Kirk R
authors.initials: RK
authors.lastname: Schultz
authors.forename: Kevin Scott
authors.initials: KS
authors.lastname: Baker
authors.forename: Jaap J
authors.initials: JJ
authors.lastname: Boelens
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Bollard
authors.forename: R Maarten
authors.initials: RM
authors.lastname: Egeler
authors.forename: Mort
authors.initials: M
authors.lastname: Cowan
authors.forename: Ruth
authors.initials: R
authors.lastname: Ladenstein
authors.forename: Arjan
authors.initials: A
authors.lastname: Lankester
authors.forename: Franco
authors.initials: F
authors.lastname: Locatelli
authors.forename: Anita
authors.initials: A
authors.lastname: Lawitschka
authors.forename: John E
authors.initials: JE
authors.lastname: Levine
authors.forename: Mignon
authors.initials: M
authors.lastname: Loh
authors.forename: Eneida
authors.initials: E
authors.lastname: Nemecek
authors.forename: Charlotte
authors.initials: C
authors.lastname: Niemeyer
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Prasad
authors.forename: Vanderson
authors.initials: V
authors.lastname: Rocha
authors.forename: Shalini
authors.initials: S
authors.lastname: Shenoy
authors.forename: Brigitte
authors.initials: B
authors.lastname: Strahm
authors.forename: Paul
authors.initials: P
authors.lastname: Veys
authors.forename: Donna
authors.initials: D
authors.lastname: Wall
authors.forename: Peter
authors.initials: P
authors.lastname: Bader
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Grupp
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pulsipher
authors.forename: Christina
authors.initials: C
authors.lastname: Peters
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007391:International Cooperation; D014184:Transplantation, Homologous
keywords: Hematopoietic cell transplantation; Pediatrics