title: Noncoding roX RNA remodeling triggers fly dosage compensation complex assembly.
abstract: Spreading of dosage compensation over the X chromosome in Drosophila males requires the noncoding roX1 and roX2 RNAs. In this issue, Ilik et al. (2013) and Maenner et al. (2013) show that these RNAs contain discrete binding sites that are remodeled during assembly of the dosage compensation complex.
authors.affiliation: Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Zürich, Schafmattstrasse 22, 8049 Zurich, Switzerland. awutz@ethz.ch
authors.forename: Anton
authors.initials: A
authors.lastname: Wutz
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D004303:Dosage Compensation, Genetic / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics*; D008297:Male; D012313:RNA / Q000235:genetics*; D020365:RNA Helicases / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D014960:X Chromosome / Q000235:genetics*
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D029721:Drosophila Proteins; C092595:Pabp2 protein, Drosophila; D016601:RNA-Binding Proteins; D014157:Transcription Factors; C070837:mle protein, Drosophila; C454144:roX1 protein, Drosophila; D012313:RNA; D000255:Adenosine Triphosphate; D004265:DNA Helicases; D020365:RNA Helicases