title: Two new terpenoid benzoates with antitumor activity from the roots of Ferula dissecta.
abstract: Two new sesquiterpene benzoates, syreiteate A (1) and syreiteate B (2), were isolated from the roots of Ferula dissecta (Ledeb.) Ledeb. Their structures were elucidated by extensive spectroscopic methods including 1D ((1)H and (13)C) NMR, 2D (HSQC, HMBC, DQF-COSY, and NOESY) NMR, and ESI-TOF-MS. Their configurations were determined on the basis of the analysis of the coupling constants, NOESY correlations, and circular dichroism spectrum. Compounds 1 and 2 showed potent growth inhibitory activity against cervical cancer HeLa cell line with the IC50 values of 13.2 and 19.3 μM, respectively.
authors.affiliation: a Department of New Drug , Institute of Frontier Medical Sciences, Jilin University , Changchun , 130021 , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Han
authors.forename: Guo-Yu
authors.initials: GY
authors.lastname: Li
authors.forename: Hang-Yu
authors.initials: HY
authors.lastname: Wang
authors.forename: Cui
authors.initials: C
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Tan
authors.forename: Ping-Ya
authors.initials: PY
authors.lastname: Li
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005260:Female; D005309:Ferula / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001565:Benzoates; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C586000:syreiteate A; C586001:syreiteate B