title: MiRNA-365 and miRNA-520c-3p respond to risperidone treatment in first-episode schizophrenia after a 1 year remission.
abstract: BACKGROUND
  MicroRNAs (miRNAs) control gene expression by destabilizing target transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human diseases, including schizophrenia. However, the effects on miRNA expression in response to antipsychotic treatment in peripheral circulation have not been thoroughly examined.
  
  
  METHODS
  Using quantitative real-time PCR (qRT-PCR), We quantified the expression of seven candidate miRNAs in plasma samples of 40 first-episode schizophrenics before and after antipsychotic treatment. The patients were all treated with risperidone and achieved remission in 1 year.
  
  
  RESULTS
  Compared with the baseline, the expression levels of miR-365 and miR-520c-3p were significantly down-regulated after 1 year of risperidone treatment (P < 0.001). There were no significant correlations between the clinical symptoms and the expression levels of these two miRNAs (P > 0.05).
  
  
  CONCLUSIONS
  This study analyzed possible circulating miRNAs in response to antipsychotic monotherapy for schizophrenia, the further mechanism need to be confirmed.
authors.affiliation: Institute of Mental Health, Peking University, Beijing, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.forename: Yan-bo
authors.initials: YB
authors.lastname: Yuan
authors.forename: Li-li
authors.initials: LL
authors.lastname: Guan
authors.forename: Hui
authors.initials: H
authors.lastname: Wei
authors.forename: Zhang
authors.initials: Z
authors.lastname: Cheng
authors.forename: Xue
authors.initials: X
authors.lastname: Han
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Cheng-cheng
authors.initials: CC
authors.lastname: Pu
authors.forename: Fu-de
authors.initials: FD
authors.lastname: Yang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Lu
authors.forename: Hong
authors.initials: H
authors.lastname: Deng
authors.forename: Jing-ping
authors.initials: JP
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents; C546819:MIRN365 microRNA, human; C575048:MIRN520 microRNA, human; D035683:MicroRNAs; D018967:Risperidone