title: Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases.
abstract: An understanding of the anatomic distributions of major neurodegenerative disease lesions is important to appreciate the differential clinical profiles of these disorders and to serve as neuropathological standards for emerging molecular neuroimaging methods. To address these issues, here we present a comparative survey of the topographical distribution of the defining molecular neuropathological lesions among 10 neurodegenerative diseases from a large and uniformly assessed brain collection. Ratings of pathological severity in 16 brain regions from 671 cases with diverse neurodegenerative diseases are summarized and analyzed. These include: 1) amyloid-β and tau lesions in Alzheimer's disease; 2) tau lesions in three other tauopathies including Pick's disease, progressive supranuclear palsy and corticobasal degeneration; 3) α-synuclein inclusion ratings in four synucleinopathies including Parkinson's disease, Parkinson's disease with dementia, dementia with Lewy bodies, and multiple system atrophy; and 4) TDP-43 lesions in two TDP-43 proteinopathies, including frontotemporal lobar degeneration associated with TDP-43 and amyotrophic lateral sclerosis. The data presented graphically and topographically confirm and extend previous pathological anatomic descriptions and statistical comparisons highlight the lesion distributions that either overlap or distinguish the diseases in each molecular disease category.
authors.affiliation: Penn Memory Center, Departments of Psychiatry and Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Arnold
authors.forename: Jon B
authors.initials: JB
authors.lastname: Toledo
authors.forename: Dina H
authors.initials: DH
authors.lastname: Appleby
authors.forename: Sharon X
authors.initials: SX
authors.lastname: Xie
authors.forename: Li-San
authors.initials: LS
authors.lastname: Wang
authors.forename: Young
authors.initials: Y
authors.lastname: Baek
authors.forename: David A
authors.initials: DA
authors.lastname: Wolk
authors.forename: Edward B
authors.initials: EB
authors.lastname: Lee
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.forename: Virginia M-Y
authors.initials: VM
authors.lastname: Lee
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000473:pathology*
keywords: Alzheimer's disease; Parkinson's disease; Parkinson's disease with dementia; Pick's disease; TDP; TDP-43; Tau α-synuclein; amyloid-β; amyotrophic lateral sclerosis; corticobasal degeneration; dementia with Lewy bodies; frontotemporal lobar degeneration; multiple system atrophy; progressive supranuclear palsy