title: [The investigation of angiotensin converting enzyme I/D and plasminogen activator inhibitor-1 4G/5G polymorphisms in venous thromboembolism patients].
abstract: BACKGROUND
  Deep venous thrombosis and pulmonary embolism, known as venous thromboembolism and seen as a fairly common multifactorial diseases. Differ between populations due to genetic factors, several polymorphisms associated with venous thromboembolism was conducted. As a result of these studies the relationship between disease development and polymorphism is not clear yet. In this study we aimed to investigate the role of angiotensin converting enzyme insersion/deletion (ACE I/D) and plasminogen activator inhibitor-1 4G/5G (PAI-1 4G/5G) polymorphism in the development of disease.
  
  
  METHODS
  In our study, DNA isolated from 80 venous thromboembolism patients and 79 control groups was used. While the classical polymerase chain reaction method used to investigate the ACE I/D polymorphism, the polymerase chain reaction based on allele-specific amplification was used for the detection of PAI-1 4G/5G polymorphism.
  
  
  RESULTS
  As a result, there were no significant statistical differences for ACE I/D and PAI-1 4G/5G polymorphism among patient and control groups (p> 0.05).
  
  
  CONCLUSIONS
  These findings revealed that there is no relationship between these polymorphisms and the development of venous thromboembolism, but large-scale studies are need to be done.
authors.affiliation: Department of Medical Biology, Gulhane Military Medical Academy, Ankara, Turkey. halidekaya@gmail.com
authors.forename: Halide
authors.initials: H
authors.lastname: Kaya
authors.forename: Mutlu
authors.initials: M
authors.lastname: Karkucak
authors.forename: Hatice
authors.initials: H
authors.lastname: Salifoğlu
authors.forename: Deniz
authors.initials: D
authors.lastname: Torun
authors.forename: Salih
authors.initials: S
authors.lastname: Kozan
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tunca
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D054556:Venous Thromboembolism / Q000097:blood / Q000235:genetics*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D007703:Peptidyl-Dipeptidase A