title: Isolation and structure elucidation of satosporin A and B: new polyketides from Kitasatospora griseola.
abstract: Satosporins A and B, two novel glucosylated polyketides, were isolated from the actinomycete Kitasatospora griseola MF730-N6. The polyketides possess an unprecedented tricyclic ring system that was fully characterized using a combination of spectroscopic analyses and computational calculations. Satosporin A was quantitatively converted into its aglycon homologue, satosporin C, using a β-glucosidase. The determination of the absolute stereochemistry was achieved using solution TDDFT/ECD calculations and chemical derivatization methods.
authors.affiliation: Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown PEI C1A 4P3, Canada.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Arens
authors.forename: Fabrice
authors.initials: F
authors.lastname: Berrué
authors.forename: Jason K
authors.initials: JK
authors.lastname: Pearson
authors.forename: Russell G
authors.initials: RG
authors.lastname: Kerr
mesh_terms: D039903:Actinobacteria / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D061065:Polyketides; C587218:satosporin A; C587219:satosporin B