title: Arterial stiffness response to exercise in persons with and without Down syndrome.
abstract: This study compared arterial stiffness and wave reflection at rest and following maximal exercise between individuals with and without Down syndrome (DS), and the influence of body mass index (BMI), peak oxygen uptake (VO2 peak) on changes in arterial stiffness. Twelve people with DS (26.6 ± 2.6 yr) and 15 healthy controls (26.2 ± 0.6 yr) completed this study. Intima-media thickness (IMT) and stiffness of common carotid artery was examined. Hemodynamic and arterial variables were measured before and 3-min after exercise. Persons with DS had higher BMI and lower VO 2 peak than controls. IMT did not differ between groups. At rest, carotid β stiffness was significantly higher in persons with DS (P<0.05) but there was no difference in between groups for any of the other arterial stiffness measures. After exercise, persons with DS exhibited attenuated arterial stiffness responses in AIx-75, carotid β stiffness and Ep in contrast with controls (significant group-by-time interactions). When controlling for BMI and VO 2 peak, the interactions disappeared. In both groups combined, BMI was correlated significantly with carotid Ep and β at rest. VO 2 peak correlated significantly with AIx-75 and its pre-post change (r=-0.45, P=0.029; r=0.47, P=0.033, respectively). The arterial stiffness responses to maximal exercise in persons with DS were blunted, potentially reflecting diminished vascular reserve. Obesity and particularly VO 2 peak influenced these findings. These results suggest impaired vascular function in people with DS.
authors.affiliation: Department of Sports and Health, Guangzhou Institute of Physical Education, Guangzhou, China.
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.forename: Huimin
authors.initials: H
authors.lastname: Yan
authors.forename: Sushant M
authors.initials: SM
authors.lastname: Ranadive
authors.forename: Stamatis
authors.initials: S
authors.lastname: Agiovlasitis
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Fahs
authors.forename: Muhammed
authors.initials: M
authors.lastname: Atiq
authors.forename: Nazia
authors.initials: N
authors.lastname: Atique
authors.forename: Bo
authors.initials: B
authors.lastname: Fernhall
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D001916:Brachial Artery / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D004314:Down Syndrome / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology*; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
keywords: Arterial property; Disability; Maximal cycle exercise; VO(2)peak; Vascular reserve