title: CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension.
abstract: Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.
authors.affiliation: aDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia bDepartment of Pharmacology, Tulane University, New Orleans, Louisiana cCollege of Nanoscale Science and Engineering, University at Albany, Albany, New York, USA.
authors.forename: Modar
authors.initials: M
authors.lastname: Kassan
authors.forename: Andrea
authors.initials: A
authors.lastname: Wecker
authors.forename: Philip
authors.initials: P
authors.lastname: Kadowitz
authors.forename: Mohamed
authors.initials: M
authors.lastname: Trebak
authors.forename: Khalid
authors.initials: K
authors.lastname: Matrougui
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications / Q000276:immunology; D001794:Blood Pressure; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004730:Endothelium, Vascular / Q000473:pathology; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000276:immunology*; D007108:Immune Tolerance; D007249:Inflammation; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism*; D051379:Mice; D008833:Microcirculation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014652:Vascular Diseases / Q000276:immunology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit