title: [Nootropics and antioxidants in the complex therapy of symptomatic posttraumatic epilepsy].
abstract: To study the possibility of application of nootropics and antioxidants in the complex antiepileptic therapy, we examined 75 patients with symptomatic focal posttraumatic epilepsy. A statistically significant reduction in the number of epileptic seizures, improvement of cognitive function and quality of life of the patients as well as a decrease in the severity of depression and epileptic changes in the EEG were identified. The potentiation of antiepileptic activity of basic drugs, normalization of brain's electrical activity and reduction in EEG epileptiform activity, in particular coherent indicators of slow-wave activity, were noted after treatment with the antioxidant mexidol. A trend towards the improvement of neuropsychological performance and quality of life was observed. There was a lack of seizure aggravation typical of many nootropic drugs. Thus, phenotropil and mexidol can be recommended for complex treatment of symptomatic posttraumatic epilepsy.
authors.forename: A A
authors.initials: AA
authors.lastname: Savenkov
authors.forename: O L
authors.initials: OL
authors.lastname: Badalian
authors.forename: G N
authors.initials: GN
authors.lastname: Avakian
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D004834:Epilepsy, Post-Traumatic / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018697:Nootropic Agents / Q000627:therapeutic use*; D010847:Picolines / Q000627:therapeutic use; D010889:Piracetam / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000975:Antioxidants; D018697:Nootropic Agents; D010847:Picolines; C070020:emoxypine succinate; C037917:4-phenylpiracetam; D010889:Piracetam