title: Asymmetric total synthesis of (+)-fusarisetin A via the intramolecular Pauson-Khand reaction.
abstract: An asymmetic total synthesis of (+)-fusarisetin A has been achieved. The essential to our strategy was the application of the intramolecular Pauson-Khand reaction for the stereoselective construction of the trans-decalin subunit of (+)-fusarisetin A with a unique C16 quarternary chiral center. The developed chemistry offers an alternative to the IMDA reaction that has been used for fusarisetin A, and is applicable to analogue synthesis for biological evaluation.
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
authors.forename: Lichao
authors.initials: L
authors.lastname: Fang
authors.forename: Rong
authors.initials: R
authors.lastname: Long
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Shi
authors.forename: Hong-Juan
authors.initials: HJ
authors.lastname: Shen
authors.forename: Chuang-chuang
authors.initials: CC
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D009281:Naphthalenes; C572422:fusarisetin A; C007229:decalin