title: Tandem Michael addition/cyclization reaction of 2,3-allenoates with organozincs: facile synthesis of isocoumarins.
abstract: A series of isocoumarin derivatives have been synthesized via the reaction of 2-(o-(methoxycarbonyl)phenyl)-2,3-allenoates with organozincs in CH2Cl2 at room temperature (for dialkylzinc) or 100 °C (for Ph2Zn) through a tandem Michael addition/intramolecular cyclization process.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Shengming
authors.initials: S
authors.lastname: Ma
mesh_terms: D002384:Catalysis; D003500:Cyclization; D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D049934:Isocoumarins; D009942:Organometallic Compounds; D015032:Zinc