title: The Roles of Moonlighting Proteins in Bacteria.
abstract: Moonlighting proteins, characterized by their multiple autonomous functions, have been detected in bacteria. Surprisingly, many of these proteins are conserved and involved in metabolic pathway or the cell stress response. They localise to the bacterial surface to take on additional activities, which have been hypothesised to contribute to bacterial virulence or bacterial benefit. In this review, we compare the functions of moonlighting proteins in bacteria, describe the structural basis of moonlighting functions, and summarise the regulation of secretion and localisation of moonlighting proteins.
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, P.R. China.
authors.forename: Guangqiang
authors.initials: G
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Xia
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.forename: Zhennan
authors.initials: Z
authors.lastname: Gu
authors.forename: Yuanda
authors.initials: Y
authors.lastname: Song
authors.forename: Yong Q
authors.initials: YQ
authors.lastname: Chen
authors.forename: Haiqin
authors.initials: H
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D001422:Bacterial Adhesion; D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D024581:Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) / Q000235:genetics* / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D056747:Immunomodulation; D010751:Phosphopyruvate Hydratase / Q000235:genetics* / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism; D019936:Probiotics / Q000494:pharmacology; D011485:Protein Binding; D021381:Protein Transport
chemical_list: D001426:Bacterial Proteins; D010958:Plasminogen; D024581:Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); D010751:Phosphopyruvate Hydratase