title: [Two cases of recurrent GIST successfully treated with imatinib mesylate at 100mg/day].
abstract: Case 1: Recurrent tumors from gastric GIST in the liver and the abdominal wall showed partial response with 200mg/day imatinib and maintained partial response at 100mg/day. Case 2: Metastatic liver tumors from the jejunal GIST showed partial response with 200mg/day imatinib. The tumors have been enlarged for interruption of imatinib administration, however, re- treatment with imatinib resulted in partial response again and kept partial response at 100mg/day of imatinib. The two cases seldom encountered adverse events at 100mg/day of imatinib. There are some cases successfully treated with low-dose imatinib mesylate for recurrent GIST.
authors.affiliation: Dept. of Surgery, Izumi General Medical Center, Japan.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Hanada
authors.forename: Kousei
authors.initials: K
authors.lastname: Kawata
authors.forename: Shigeki
authors.initials: S
authors.lastname: Okamura
authors.forename: Nariaki
authors.initials: N
authors.lastname: Tomiyama
authors.forename: Kazuki
authors.initials: K
authors.lastname: Hori
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology; D034861:Abdominal Wall / Q000473:pathology; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001549:Benzamides / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007078:Ileal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate