title: Diagnostic accuracy of neutrophil CD64 expression in neonatal infection: a meta-analysis.
abstract: OBJECTIVE
  The aim of the present study was to establish the predictive values of neutrophil CD64 expression in diagnosing neonatal infection.
  
  
  METHODS
  A comprehensive search of the PubMed and Embase® literature databases identified outcome data from published studies estimating the diagnostic accuracy of neutrophil CD64 expression for neonatal infection. Summary estimates for sensitivity, specificity, diagnostic odds ratios (DOR) and the area under the summary receiver operating characteristic curve (AUC) were calculated using a bivariate random-effects approach.
  
  
  RESULTS
  Twelve studies including 1915 neonates were analysed. Summary estimates (95% confidence intervals) for CD64 expression in the diagnosis of neonatal infection were: sensitivity, 0.78 (0.75, 0.81); specificity, 0.81 (0.78, 0.83); DOR, 21.27 (11.71, 38.65); positive-likelihood ratio, 4.53 (3.22, 6.36); negative-likelihood ratio, 0.23 (0.14, 0.37); AUC, 0.89.
  
  
  CONCLUSIONS
  Neutrophil CD64 expression can be used as an additional test in the diagnosis of neonatal infection. Results of a CD64 assay should not be used alone to diagnose such infections, but should be interpreted in combination with other test results and clinical findings.
authors.affiliation: Division of Medicine, West China Hospital of Sichuan University, Sichuan, Chengdu, China.
authors.forename: Liu-Qun
authors.initials: LQ
authors.lastname: Jia
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Shen
authors.forename: Qian-Jing
authors.initials: QJ
authors.lastname: Hu
authors.forename: Chun
authors.initials: C
authors.lastname: Wan
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Wen
mesh_terms: D016470:Bacteremia / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D001424:Bacterial Infections / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D016206:Databases, Bibliographic; D015870:Gene Expression; D006801:Humans; D007231:Infant, Newborn; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D016017:Odds Ratio; D011379:Prognosis; D012372:ROC Curve; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology*
chemical_list: D015415:Biomarkers; D017452:Receptors, IgG
keywords: CD64; Neonatal infection; diagnosis; meta-analysis