title: Channels: Sticking to nooks and crannies.
abstract: Drug design for voltage-gated ion channels has long been hampered by the absence of crystal structures and the challenge of achieving subtype selectivity. A combination of mutagenesis, electrophysiology and molecular modeling has led to the identification of a new side pocket binding site for the small molecule Psora-4 between the pore and the voltage-sensor domain of Kv1.5, offering opportunities to design allosteric ion channel modulators.
authors.forename: Heike
authors.initials: H
authors.lastname: Wulff
authors.forename: Vladimir
authors.initials: V
authors.lastname: Yarov-Yarovoy
mesh_terms: D051666:Kv1.5 Potassium Channel / Q000037:antagonists & inhibitors* / Q000737:chemistry*
chemical_list: D051666:Kv1.5 Potassium Channel