title: Hypalgesia effect of IL-24, a quite new mechanism for IL-24 application in cancer treatment.
abstract: Tumor suppressor melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) has been extensively regarded as an anti-oncogene; however, that whether IL-24, as a member of IL-10 family, is involved in cancer pain was seldom reported before. In this study, we found that IL-24 mediated by adenovirus could significantly increase the plantar mechanical pain threshold in both operation side and contralateral side of the animal models, which were established by injecting 5×103 Walker 256 rat breast cancer ascitic tumor cells into rats' tibia bone medullary canals; IL-24 could also suppress in vitro Walker 256 cells growth by inducing cell apoptosis. Pathologically, IL-24 could protect bone trabecula and substantia corticalis ossium from being completely destructed. Enzyme-linked immunosorbent assay (ELISA) showed that IL-24 treatment could increase the β-endorphin levels and decrease the IL-6 concentration in plasma of animals. Our study indicated that IL-24 has a potential treatment effect on cancers not only by inhibiting tumor proliferation, but also by the promotion of β-endorphin synthesis, inhibition of IL-6 secretion to relieve cancer pain.
authors.affiliation: 1 Shanghai 10th People's Hospital, School of Medicine, Tongji University , Shanghai, China .
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Weihua
authors.initials: W
authors.lastname: Sheng
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Miao
authors.forename: Jicheng
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D045744:Cell Line, Tumor; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D015870:Gene Expression; D006930:Hyperalgesia / Q000235:genetics* / Q000378:metabolism; D007378:Interleukins / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D017288:Pain Threshold; D051381:Rats; D000099180:Interleukin-24
chemical_list: D016207:Cytokines; D007378:Interleukins; D000099180:Interleukin-24