title: Triterpenoids and steroids with cytotoxic activity from Emmenopterys henryi.
abstract: Two new ursane-type triterpenoids, 3β,19α,23-trihydroxyurs-12-en-24-al-28-oic acid (1) and 3β,19α,24-trihydroxy-23-norurs-12-en-28-oic acid (2), two new pregnane derivatives, 3β,12β-dihydroxy-5α-pregnane-14,16-dien-20-one (9) and 12β-hydroxy-5α-pregnane-14,16-dien-3,20-dione (10), and eight known compounds were isolated from the twigs and leaves of Emmenopterys henryi. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 4, 11, and 12 showed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines with IC50 values in the range of 3.11-20.12 µM.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Xing-Yao
authors.initials: XY
authors.lastname: Li
authors.forename: Liao-Bin
authors.initials: LB
authors.lastname: Dong
authors.forename: Xun
authors.initials: X
authors.lastname: Gong
authors.forename: Xiu
authors.initials: X
authors.lastname: Gao
authors.forename: Liu-Dong
authors.initials: LD
authors.lastname: Song
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018922:HL-60 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D018547:Plant Stems; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D019666:Rubiaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D011278:Pregnanes; D014315:Triterpenes