title: Association of FCRL3 genotypes with susceptibility of Iranian patients to rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is a complex disease, the hallmark of which is synovial joint inflammation. The substantial contribution from genetic factors in susceptibility to RA has been well-defined. The Fc receptor-like3 (FCRL3) gene is one of the genes that have recently shown a significant association with RA. To determine the possible role of FCRL3-169 C/T and FCRL3-110 A/G gene polymorphisms in the development of RA in Iranian patients, 320 RA patients and 302 healthy subjects were genotyped by polymerase chain reaction-restriction fragment length polymorphism. No significant difference was found in genotype and allele frequencies of FCRL3-169 C/T between patients and controls. In contrast, at position -110 A/G, the frequency of the AA genotype and A allele was significantly decreased in RA patients compared to controls (p = 0.005). After Bonferroni correction for multiple testing, no significant correlations between FCRL3-169 C/T and -110 A/G polymorphism and laboratory and clinical features of the patients was observed. In conclusion, the results of this study showed a significant association between FCRL3-110 A/G polymorphism and susceptibility to RA.
authors.affiliation: Immunology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Golmoghaddam
authors.forename: Zahra
authors.initials: Z
authors.lastname: Amirghofran
authors.forename: Elham
authors.initials: E
authors.lastname: Aflaki
authors.forename: Eskandar
authors.initials: E
authors.lastname: Kamali-Sarvestani
authors.forename: Mahdi
authors.initials: M
authors.lastname: Shabani
authors.forename: Maryam
authors.initials: M
authors.lastname: Esmaeilbeig
authors.forename: Mona
authors.initials: M
authors.lastname: Rajabi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000235:genetics*; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000097:blood; D007492:Iran; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D012217:Rheumatoid Factor / Q000097:blood; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: C457775:FCRL3 protein, human; D007126:Immunoglobulin Allotypes; D010456:Peptides, Cyclic; D011971:Receptors, Immunologic; C487763:cyclic citrullinated peptide; D002097:C-Reactive Protein; D012217:Rheumatoid Factor