title: Classification of cardiovascular time series based on different coupling structures using recurrence networks analysis.
abstract: We analyse cardiovascular time series with the aim of performing early prediction of preeclampsia (PE), a pregnancy-specific disorder causing maternal and foetal morbidity and mortality. The analysis is made using a novel approach, namely the ε-recurrence networks applied to a phase space constructed by means of the time series of the variabilities of the heart rate and the blood pressure (systolic and diastolic). All the possible coupling structures among these variables are considered for the analysis. Network measures such as average path length, mean coreness, global clustering coefficient and scale-local transitivity dimension are computed and constitute the parameters for the subsequent quadratic discriminant analysis. This allows us to predict PE with a sensitivity of 91.7 per cent and a specificity of 68.1 per cent, thus validating the use of this method for classifying healthy and preeclamptic patients.
authors.affiliation: Institut für Physik, Humboldt-Universität zu Berlin, Berlin, Germany.
authors.forename: Gonzalo Marcelo
authors.initials: GM
authors.lastname: Ramírez Ávila
authors.forename: Andrej
authors.initials: A
authors.lastname: Gapelyuk
authors.forename: Norbert
authors.initials: N
authors.lastname: Marwan
authors.forename: Thomas
authors.initials: T
authors.lastname: Walther
authors.forename: Holger
authors.initials: H
authors.lastname: Stepan
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kurths
authors.forename: Niels
authors.initials: N
authors.lastname: Wessel
mesh_terms: D000465:Algorithms; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008954:Models, Biological; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology*; D011247:Pregnancy; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: blood flow in cardiovascular system; cardiac dynamics; coupling analysis; hemodynamics; networks and genealogical trees; time-series analysis