title: Cardiac dysfunction in pneumovirus-induced lung injury in mice.
abstract: OBJECTIVE
  To determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice.
  
  
  METHODS
  Experimental animal study.
  
  
  METHODS
  Animal laboratory.
  
  
  METHODS
  C57Bl/6 mice.
  
  
  METHODS
  Mice were inoculated with the rodent pneumovirus, pneumonia virus of mice.
  
  
  RESULTS
  Pneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found.
  
  
  CONCLUSIONS
  These findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart.
authors.affiliation: Pediatric Intensive Care Unit, Emma Children's Hospital AMC, Amsterdam, The Netherlands. r.a.bem@amc.uva.nl
authors.forename: Reinout A
authors.initials: RA
authors.lastname: Bem
authors.forename: Elske
authors.initials: E
authors.lastname: van den Berg
authors.forename: Ernst
authors.initials: E
authors.lastname: Suidgeest
authors.forename: Louise
authors.initials: L
authors.lastname: van der Weerd
authors.forename: Job B M
authors.initials: JB
authors.lastname: van Woensel
authors.forename: Heynric B
authors.initials: HB
authors.lastname: Grotenhuis
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology* / Q000503:physiopathology; D000818:Animals; D016207:Cytokines / Q000097:blood*; D004195:Disease Models, Animal; D005260:Female; D008279:Magnetic Resonance Imaging; D051379:Mice; D008810:Mice, Inbred C57BL; D018186:Pneumovirus Infections / Q000150:complications*; D013318:Stroke Volume; D018754:Ventricular Dysfunction / Q000209:etiology* / Q000503:physiopathology
chemical_list: D016207:Cytokines