title: Multi-components of evoked-brain potentials in deficit and nondeficit schizophrenia.
abstract: BACKGROUND
  The present study aims to detect the specific and common impairment index relative to evoked brain potentials (EBPS ) in deficit schizophrenia (DS) and nondeficit schizophrenia (NDS), and investigates the relationship between EBPs and clinical variables.
  
  
  METHODS
  The study used EBPs in 21 patients with DS, 38 patients with NDS, and 50 healthy controls (HCs) to investigate P300 waves, mismatch negative (MMN), sensory gating (SG) P50 and contingent negative variation (CNV). A comparison of three groups and the relationship between EBPs and clinical variables were performed using general linear model analyses and partial correlation, respectively.
  
  
  RESULTS
  Compared with HCs, both groups of patients showed delayed N1 , N2 , and P3a latency, and reduced N1 and N2 amplitude. The MMN showed delayed latency. The P50 ratios and the inhibited ratios were impaired, whereas SG loss ratios increased. CNV amplitude was reduced. Compared with HCs, NDS showed delayed latency of S2'-C in CNV, whereas DS showed shortened latency. Only NDS, when compared with HCs, showed delayed latency of P3b , Also, only DS, when compared with HCs, showed delayed latency of point A in CNV. Latency of point A in CNV of DS, correlated with a poorer Global Assessment of Functioning Scale (6 weeks) and was independent of clinical characteristics.
  
  
  CONCLUSIONS
  Schizophrenia represents a clinical syndrome with shared impairments in brain function, whereas DS is a relatively homogeneous subgroup of schizophrenia with unique pathophysiological changes.
authors.affiliation: Mental Health Center and the Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Zheng
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Zheng
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000503:physiopathology*; D016022:Case-Control Studies; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D055815:Young Adult
keywords: deficit schizophrenia; evoked brain potential; nondeficit schizophrenia