title: Safety and efficacy of photoselective vaporization of prostate in patients receiving anticoagulants.
abstract: OBJECTIVE
  Objective of the present study was to evaluate the safety and efficacy of photoselective vaporization of the prostate (PVP) using a 80W potassium titanyl phosphate (KTP) laser, in benign prostatic enlargement (BPE) patients who were on ongoing anticoagulant therapy during the perioperative period.
  
  
  METHODS
  Prospectively collected laser prostatectomy patient database of our hospital for the period between July 2009-Jan 2012 was retrospectively reviewed. Data on perioperative safety, functional outcome and complications up to follow-up at 6 months of 45 eligible patients who underwent PVP-KTP and were on perioperative anticoagulant therapy (study group) was compared with 47 eligible patients who underwent PVP-KTP and were not on perioperative anticoagulant therapy (control group). P<0.05 was considered statistically significant.
  
  
  RESULTS
  The baseline characteristics of the two groups were similar except for ASA score which was significantly higher in the study group.(2.64±0.60 vs. 1.53±0.50). Though the need (15.55% vs. 4.25% patients) and duration of postoperative irrigation (243.33±49.66 vs. 52.5±10.60 min) was significantly higher in the study group, the postoperative hemoglobin drop 24 hours postoperatively did not differ significantly between the two groups (8.54% vs. 6.48%). No patient required a blood transfusion. The overall complication rate was similar in the two groups. In both groups, significant improvement was recorded in the IPSS, QOL, Q max, PVRU and prostate volume data upto 6 months follow up with no significant differences noted.
  
  
  CONCLUSIONS
  KTP-PVP can be performed safely and effectively in BPE patients on ongoing anticoagulation, without increasing the risk of perioperative bleeding or the need for blood transfusion.
authors.affiliation: Department of Urology V.M. Medical College and Safdarjang Hospital New Delhi, India - drpawanvasudeva@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Pawan
authors.forename: K
authors.initials: K
authors.lastname: Anup
authors.forename: K
authors.initials: K
authors.lastname: Niraj
authors.forename: N
authors.initials: N
authors.lastname: Biswajit
authors.forename: R
authors.initials: R
authors.lastname: Punita
authors.forename: A
authors.initials: A
authors.lastname: Rajendra
authors.forename: M
authors.initials: M
authors.lastname: Nayan
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000601:surgery*; D012189:Retrospective Studies; D020728:Transurethral Resection of Prostate / Q000009:adverse effects
chemical_list: D000925:Anticoagulants