title: The effects of lornoxicam on brain edema and blood brain barrier following diffuse traumatic brain injury in rats.
abstract: BACKGROUND
  In this experiment, the effects of lornoxicam on brain edema and the blood brain barrier (BBB) following diffuse traumatic brain injury (TBI) were studied.
  
  
  METHODS
  Twenty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by the Marmarou method. After head injury, the rats were randomly divided into two groups: Group I was the control group, to which 2 ml saline was administered intraperitoneally, and Group II was the lornoxicam group, to which 2 ml 1.3 mg kg-1 lornoxicam was administered intraperitoneally. Twenty-four hours after head trauma, 99 mTc pentetate (DTPA) was injected at a dose of 37 MBq, and posterior planar images of each rat were obtained using an Infinia gamma camera. After imaging of BBB permeability, brain tissues were dissected from the cranium. The brain water content (BWC) of each sample was calculated using the wet-dry method.
  
  
  RESULTS
  The lesion/background (L/b) ratio of Group I was 3.76±0.46 and 3.02±0.66 for early (5th min) and late (60th min) imaging, respectively. In Group II, the L/b ratios were 3.52±0.96 and 2.63±0.63 for early and late imaging, respectively (p>0.05). BWC was 79.6±2.5% and 77.5±1.1% for Groups I and II, respectively (p<0.05).
  
  
  CONCLUSIONS
  In this rat model of TBI, lornoxicam reduced brain edema but did not affect BBB permeability.
authors.affiliation: Department of Anesthesiology and Intensive Care, Celal Bayar University Faculty of Medicine, Manisa, Turkey. topcuismet@yahoo.com
authors.forename: Ismet
authors.initials: I
authors.lastname: Topçu
authors.forename: Gül
authors.initials: G
authors.lastname: Gümüşer
authors.forename: Eda
authors.initials: E
authors.lastname: Bayram
authors.forename: Feray
authors.initials: F
authors.lastname: Aras
authors.forename: Ismail
authors.initials: I
authors.lastname: Cetin
authors.forename: Cüneyt
authors.initials: C
authors.lastname: Temiz
authors.forename: Melek
authors.initials: M
authors.lastname: Civi
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001929:Brain Edema / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018696:Neuroprotective Agents; D010894:Piroxicam; C059451:lornoxicam