title: Ventricular response to dobutamine stress relates to the change in peak oxygen uptake during the 5-year follow-up in young patients with repaired tetralogy of Fallot.
abstract: OBJECTIVE
  To evaluate the additional value of dobutamine stress testing in patients with repaired tetralogy of Fallot (TOF) by relating stress imaging parameters at baseline to relevant parameters of clinical condition and right ventricular (RV) size during a serial follow-up.
  
  
  RESULTS
  We prospectively included 27 patients (14 ± 4 years at baseline), who were studied twice with a 5-year interval. Patients underwent cardiovascular magnetic resonance imaging to assess RV systolic and diastolic function at rest and during dobutamine stress. Normal response to dobutamine was defined as a decrease in RV end-systolic volume, and a increase in RV ejection fraction (EF) during stress. Exercise testing and electrocardiography were performed to determine peak oxygen uptake (peak VO₂), QRS duration, and QT interval corrected for heart rate (QTc) interval. RV volumes, QRS duration, and QTc interval increased significantly from baseline to follow-up; peak VO₂ tended to decrease (95 ± 20-89 ± 14%, P = 0.086). Response to dobutamine was normal in 26 of 27 patients and remained stable during the follow-up [relative increase in RVEF during stress: +25 ± 9% (baseline) vs. +27 ± 10% (follow-up)]. A smaller relative increase in RVEF during stress at baseline related to a larger relative decrease in peak VO₂ during the follow-up (r = 0.59, P = 0.004). No significant associations were found with the relative increase in QRS duration, QTc interval, or RV end-diastolic volume during a 5-year follow-up.
  
  
  CONCLUSIONS
  In a young TOF population, response to dobutamine stress was normal and remained stable during the 5-year follow-up. A smaller increase in RVEF during stress at baseline was predictive for a larger decrease in peak VO₂ during the 5-year follow-up.
authors.affiliation: Department of Pediatrics, Division of Cardiology, Erasmus Medical Center-Sophia Children's Hospital, Sp-2426, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
authors.forename: Saskia E
authors.initials: SE
authors.lastname: Luijnenburg
authors.forename: Selma
authors.initials: S
authors.lastname: Mekic
authors.forename: Jochem
authors.initials: J
authors.lastname: van den Berg
authors.forename: Rob J
authors.initials: RJ
authors.lastname: van der Geest
authors.forename: Adriaan
authors.initials: A
authors.lastname: Moelker
authors.forename: Jolien W
authors.initials: JW
authors.lastname: Roos-Hesselink
authors.forename: Ad J J C
authors.initials: AJ
authors.lastname: Bogers
authors.forename: Yolanda B
authors.initials: YB
authors.lastname: de Rijke
authors.forename: Jan L M
authors.initials: JL
authors.lastname: Strengers
authors.forename: Barbara J M
authors.initials: BJ
authors.lastname: Mulder
authors.forename: Hubert W
authors.initials: HW
authors.lastname: Vliegen
authors.forename: Willem A
authors.initials: WA
authors.lastname: Helbing
mesh_terms: D000293:Adolescent; D004280:Dobutamine; D025401:Echocardiography, Stress / Q000379:methods; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology*; D011446:Prospective Studies; D013771:Tetralogy of Fallot / Q000503:physiopathology* / Q000601:surgery; D014665:Vasodilator Agents; D016278:Ventricular Function, Right / Q000502:physiology*; D055815:Young Adult
chemical_list: D014665:Vasodilator Agents; D004280:Dobutamine
keywords: cardiovascular magnetic resonance imaging; dobutamine stress; exercise capacity; serial follow-up; tetralogy of Fallot