title: Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines.
abstract: It is well known that resveratrol (RSV) displayed cancer-preventing and anticancer properties but its clinical application is limited because of a low bioavailability and a rapid clearance from the circulation. Aim of this work was to synthesize pharmacologically active resveratrol analogs with an enhanced structural rigidity and bioavailability. In particular, we have synthesized a library of 2,3-thiazolidin-4-one derivatives in which a thiazolidinone nucleus connects two aromatic rings. Some of these compounds showed strong inhibitory effects on breast cancer cell growth. Our results indicate that some of thiazolidin-based resveratrol derivatives may become a new potent alternative tool for the treatment of human breast cancer.
authors.affiliation: Department of Pharmaceutical Science, Division of Biomedicine, University of Salerno, Fisciano, SA 84084, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Sala
authors.forename: Adele
authors.initials: A
authors.lastname: Chimento
authors.forename: Carmela
authors.initials: C
authors.lastname: Saturnino
authors.forename: Isabel M
authors.initials: IM
authors.lastname: Gomez-Monterrey
authors.forename: Simona
authors.initials: S
authors.lastname: Musella
authors.forename: Alessia
authors.initials: A
authors.lastname: Bertamino
authors.forename: Ciro
authors.initials: C
authors.lastname: Milite
authors.forename: Maria Stefania
authors.initials: MS
authors.lastname: Sinicropi
authors.forename: Anna
authors.initials: A
authors.lastname: Caruso
authors.forename: Rosa
authors.initials: R
authors.lastname: Sirianni
authors.forename: Paolo
authors.initials: P
authors.lastname: Tortorella
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
authors.forename: Pietro
authors.initials: P
authors.lastname: Campiglia
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pezzi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045162:Thiazolidinediones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D045162:Thiazolidinediones; D000077185:Resveratrol
keywords: 2,3-Thiazolidin-4-one derivatives; Breast cancer cells; MCF-7; Polyphenol; Resveratrol analogs anticancer drugs; SKBR3