title: The redox-associated adaptive response of brain to physical exercise.
abstract: Reactive oxygen species (ROS) are continuously generated during metabolism. ROS are involved in redox signaling, but in significant concentrations they can greatly elevate oxidative damage leading to neurodegeneration. Because of the enhanced sensitivity of brain to ROS, it is especially important to maintain a normal redox state in brain and spinal cord cell types. The complex effects of exercise benefit brain function, including functional enhancement as well as its preventive and therapeutic roles. Exercise can induce neurogenesis via neurotrophic factors, increase capillarization, decrease oxidative damage, and enhance repair of oxidative damage. Exercise is also effective in attenuating age-associated loss in brain function, which suggests that physical activity-related complex metabolic and redox changes are important for a healthy neural system.
authors.affiliation: Faculty of Physical Education and Sport Sciences, Institute of Sport Science, Semmelweis University , Budapest , Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Radak
authors.forename: F
authors.initials: F
authors.lastname: Ihasz
authors.forename: E
authors.initials: E
authors.lastname: Koltai
authors.forename: S
authors.initials: S
authors.lastname: Goto
authors.forename: A W
authors.initials: AW
authors.lastname: Taylor
authors.forename: I
authors.initials: I
authors.lastname: Boldogh
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species