title: Synthesis of C-2 arylated tryptophan amino acids and related compounds through palladium-catalyzed C-H activation.
abstract: Tryptophan (Trp) and tryptophan derivatives are C2-arylated. A C-H activation process allows the preparation of both protected and unprotected arylated-Trp amino acids, directly from the amino acid precursor and aryl iodides. The obtained compounds are suitable for standard solid-phase peptide synthesis.
authors.affiliation: Barcelona Science Park, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Preciado
authors.forename: Lorena
authors.initials: L
authors.lastname: Mendive-Tapia
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Lavilla
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D014364:Tryptophan / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D009942:Organometallic Compounds; D010165:Palladium; D014364:Tryptophan