title: Hyperbaric oxygen therapy does not improve the effects of standardized treatment in a severe attack of ulcerative colitis: a prospective randomized study.
abstract: OBJECTIVE
  Complementary therapy options are needed in the treatment of active ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) has been shown to have positive effects in experimental models of colitis and perianal Crohn's disease.
  
  
  METHODS
  In the present prospective randomized open-label study, HBOT in addition to conventional medical treatment was compared with conventional treatment alone. The primary objective in this study was improved clinical outcome evaluated by Mayo score, laboratory tests and fecal weight. The secondary objectives were improvement in health-related quality of life, avoidance of colectomy and evaluation of HBOT safety.
  
  
  RESULTS
  The authors found no statistically significant differences between the treatment groups in any of the assessed variables.
  
  
  CONCLUSIONS
  The study results do not support the use of HBOT as a treatment option in a severe attack of UC.
authors.affiliation: Department of Internal Medicine and Geriatrics, Sahlgrenska University Hospital/Östra Hospital, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Pagoldh
authors.forename: Elin
authors.initials: E
authors.lastname: Hultgren
authors.forename: Per
authors.initials: P
authors.lastname: Arnell
authors.forename: Anders
authors.initials: A
authors.lastname: Eriksson
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001623:Betamethasone / Q000627:therapeutic use; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D011446:Prospective Studies; D011788:Quality of Life; D017211:Treatment Failure
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine; D001623:Betamethasone; D011239:Prednisolone