title: Serum oxidant and antioxidant status following an all-out 21-km run in adolescent runners undergoing professional training--a one-year prospective trial.
abstract: This study investigated the 1-year longitudinal effect of professional training in adolescent runners on redox balance during intense endurance exercise. Changes in selected serum oxidant and antioxidant status in response to a 21-km running time trial in 10 runners (15.5 ± 1.3 years) undergoing professional training were evaluated twice in 12 months (pre- and post-evaluation). Venous blood samples were collected immediately before and 4-h following the 21-km run for analysis of serum concentrations of thiobarbituric acid-reactive substances (TBARS), xanthine oxidase (XO), catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC). In pre-evaluation trial, serum TBARS and SOD decreased after the 21-km run (p < 0.05) while XO, GSH, CAT and TAOC were unchanged. In post-evaluation trial, serum TBARS and SOD decreased, whereas XO and CAT increased post-exercise (p < 0.05). Furthermore, pre-exercise serum T-AOC, post-exercise serum XO, CAT, T-AOC (p < 0.05), and GSH (p = 0.057) appeared to be higher than the corresponding pre-evaluation values. The current findings suggest that a professional training regime in adolescent runners is not likely to jeopardize the development of their antioxidant defense. However, uncertainties in the maintenance of redox balance in runners facing increased exercise-induced oxidative stress as a consequence of training-induced enhancement of exercise capacity await further elucidation.
authors.affiliation: Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Department of Physical Education, Hong Kong Baptist University, Hong Kong, China. tongkk@hkbu.edu.hk
authors.forename: Tom K
authors.initials: TK
authors.lastname: Tong
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Kong
authors.forename: Hua
authors.initials: H
authors.lastname: Lin
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
authors.forename: Haifeng
authors.initials: H
authors.lastname: Zhang
authors.forename: Jinlei
authors.initials: J
authors.lastname: Nie
mesh_terms: D000293:Adolescent; D002374:Catalase / Q000097:blood*; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D011446:Prospective Studies; D012420:Running; D013482:Superoxide Dismutase / Q000097:blood*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*; D013997:Time Factors; D014969:Xanthine Oxidase / Q000097:blood*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D005978:Glutathione