title: Genetic variants and signatures of selective sweep of Hanwoo population (Korean native cattle).
abstract: Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequenced the genomes of 12 cattle, and identified 15125420 SNPs, 1768114 INDELs, and 3445 CNVs. The SNPs, INDELs, and CNVs were similarly distributed throughout the genome, and highly variable regions were shown to contain the BoLA family and GPR180, which are related to adaptive immunity. We also identified the domestication footprints of the Hanwoo population by searching for selective sweep signatures, which revealed the RCN2 gene related to BPV resistance. The results of this study may contribute to genetic improvement of the Hanwoo population in Korea.
authors.affiliation: Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Korea.
authors.forename: Taeheon
authors.initials: T
authors.lastname: Lee
authors.forename: Seoae
authors.initials: S
authors.lastname: Cho
authors.forename: Kang Seok
authors.initials: KS
authors.lastname: Seo
authors.forename: Jongsoo
authors.initials: J
authors.lastname: Chang
authors.forename: Heebal
authors.initials: H
authors.lastname: Kim
authors.forename: Duhak
authors.initials: D
authors.lastname: Yoon
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000235:genetics; D002417:Cattle; D056915:DNA Copy Number Variations; D014644:Genetic Variation; D016678:Genome; D054643:INDEL Mutation; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D056910:Republic of Korea
chemical_list: D002135:Calcium-Binding Proteins; D024101:Mitochondrial Proteins; D043562:Receptors, G-Protein-Coupled