title: Synthesis, spectroscopic and radical scavenging studies of palladium(II)-hydrazide complexes.
abstract: In present study, a series of palladium(II) complexes with biologically active hydrazide ligands have been synthesized, characterized and screened for their antioxidant (superoxide and DPPH radical scavenging) properties. Spectral studies (FT-IR, EI-mass, (13)C and (1)H NMR spectroscopy) and physico-chemical measurements including elemental analysis, magnetic susceptibility and conductivity measurements represented square planar structure for all complexes. Substituted and unsubstituted benzohydrazides (1-4) have shown monodentate behavior forming complexes of general formula [PdL2Cl2]. However, pyridinecarbohydrazides (5 and 6) were coordinated in bidentate fashion of [PdLCl2] general formula producing stable five-membered chelate ring. All palladium complexes were found to be considerably more potent inhibitors of DPPH free radical compared to free hydrazides. These complexes are even stronger DPPH scavengers than standard antioxidant propyl gallate. The complexes have also shown good superoxide scavenging ability compared to inactive free hydrazides, however complexes are weaker superoxide scavengers than ascorbic acid, a standard superoxide inhibitor. An interesting structure activity relationship has been evaluated.
authors.affiliation: Department of Chemistry, University of Karachi, Karachi 75270, Pakistan. ainychem85@gmail.rcom
authors.forename: Qurrat
authors.initials: Q
authors.lastname: Ul Ain
authors.forename: Uzma
authors.initials: U
authors.lastname: Ashiq
authors.forename: Rifat Ara
authors.initials: RA
authors.lastname: Jamal
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mahrooof-Tahir
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D055598:Chemical Phenomena; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction / Q000187:drug effects; D010165:Palladium / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D056831:Coordination Complexes; D016166:Free Radical Scavengers; D006834:Hydrazines; D008024:Ligands; D010851:Picrates; D013481:Superoxides; D010165:Palladium; C004931:1,1-diphenyl-2-picrylhydrazyl; D013482:Superoxide Dismutase
keywords: Antioxidants; DPPH radical; Hydrazide; Palladium(II); Superoxide