title: Low-density lipoproteins oxidation and endometriosis.
abstract: The etiopathogenesis of endometriosis still remains unknown. Recent data provide new valuable information concerning the role of oxidative stress in the pathophysiology of the disease. It has been proved that levels of different lipid peroxidation end products are increased in both peritoneal fluid (PF) and serum of endometriotic patients. We assessed the concentration of oxidized low-density lipoproteins (oxLDL) in PF of 110 women with different stages of endometriosis and 119 women with serous (n = 78) or dermoid (n = 41) ovarian cysts, as the reference groups. PF oxLDL levels were evaluated by ELISA. We found that concentrations of oxLDL in PF of endometriotic women were significantly higher compared to women with serous but not dermoid ovarian cysts. Interestingly, by analyzing concentrations of oxLDL in women with different stages of the disease, it was noted that they are significantly higher only in the subgroup of patients with stage IV endometriosis as compared to women with ovarian serous cysts. In case of minimal, mild, and moderate disease, PF oxLDL levels were similar to those noted in reference groups. Our results indicate that disrupted oxidative status in the peritoneal cavity of women with endometriosis may play a role in the pathogenesis of advanced stages of the disease.
authors.affiliation: 1st Department of Oncological Gynecology and Gynecology, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland. polakg@yahoo.com
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Polak
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Barczyński
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kwaśniewski
authors.forename: Wiesława
authors.initials: W
authors.lastname: Bednarek
authors.forename: Iwona
authors.initials: I
authors.lastname: Wertel
authors.forename: Magdalena
authors.initials: M
authors.lastname: Derewianka-Polak
authors.forename: Jan
authors.initials: J
authors.lastname: Kotarski
mesh_terms: D000293:Adolescent; D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism; D018450:Disease Progression; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D010535:Laparoscopy; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008875:Middle Aged; D010048:Ovarian Cysts / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D010100:Oxygen / Q000737:chemistry; D055815:Young Adult
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D010100:Oxygen