title: Regioselective synthesis of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-diones as potent antitumoral agents.
abstract: Three-component coupling of aldehyde, 2-hydroxy-1,4-naphthoquinone and 3-amino-1,2,4-triazole has been achieved using a catalytic amount of sulfamic acid under solvent free conditions to produce a novel series of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-dione derivatives in good yields and with high regioselectivity. These compounds are found to exhibit potent antitumoral properties.
authors.affiliation: School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China. wliq1974@163.com
authors.forename: Liqiang
authors.initials: L
authors.lastname: Wu
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
authors.forename: Weilin
authors.initials: W
authors.lastname: Li
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002384:Catalysis; D045744:Cell Line, Tumor; D056945:Hep G2 Cells; D006801:Humans; D009285:Naphthoquinones / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000447:Aldehydes; D000970:Antineoplastic Agents; D009285:Naphthoquinones; D011799:Quinazolines; D013451:Sulfonic Acids; D014230:Triazoles; C005741:sulfamic acid; C035342:1,4-naphthoquinone
keywords: 2-Hydroxy-1,4-naphthoquinone; Aldehydes; Antitumor; Ortho-Naphthoquinone; Solvent-free; Sulfamic acid