title: Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis.
abstract: OvoA is an iron(II) dependent sulfoxide synthase which catalyzes the first step in ovothiol A biosynthesis. This enzyme sulphurizes the C5 position of the imidazole side chain of L-histidine. We report the substrate specificity profile of this catalyst and present data which indicate that OvoA catalysis follows an thiol-ene type mechanism.
authors.affiliation: Department for Chemistry, University of Basel, St. Johanns-Ring 19, Basel, Switzerland.
authors.forename: Gabriel T M
authors.initials: GT
authors.lastname: Mashabela
authors.forename: Florian P
authors.initials: FP
authors.lastname: Seebeck
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D055162:Biocatalysis; D004885:Erwinia / Q000201:enzymology; D007093:Imidazoles / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D007700:Kinetics; D008762:Methylhistidines / Q000737:chemistry / Q000378:metabolism*; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000378:metabolism*; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D001426:Bacterial Proteins; D007093:Imidazoles; D008762:Methylhistidines; C061475:ovothiol A; C029899:imidazole; D007501:Iron; D050862:Oxidoreductases Acting on Sulfur Group Donors; D010100:Oxygen