title: Interactions between alcohol and the HIV entry inhibitor Maraviroc.
abstract: BACKGROUND
  Alcohol use is common among people with HIV, and beliefs about alcohol interactions with medications predict decreased medication adherence, risking drug-resistant mutations. Maraviroc is an HIV entry inhibitor approved for treatment of both drug-sensitive and drug-resistant HIV strains. The present study evaluated the effects of alcohol on maraviroc pharmacokinetics and the effects of maraviroc on alcohol pharmacokinetics.
  
  
  METHODS
  Ten healthy adults completed alcohol (1 g/kg) and placebo alcohol pharmacokinetics sessions before and after 7 days of maraviroc administration.
  
  
  RESULTS
  Alcohol concentrations increased 12% following maraviroc. Maraviroc pharmacokinetics were unaffected by alcohol.
  
  
  CONCLUSIONS
  Maraviroc treatment should not be interrupted if alcohol is consumed.
authors.affiliation: Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA.
authors.forename: Valerie A
authors.initials: VA
authors.lastname: Gruber
authors.forename: Petrie M
authors.initials: PM
authors.lastname: Rainey
authors.forename: Paula J
authors.initials: PJ
authors.lastname: Lum
authors.forename: George W
authors.initials: GW
authors.lastname: Beatty
authors.forename: Francesca T
authors.initials: FT
authors.lastname: Aweeka
authors.forename: Elinore F
authors.initials: EF
authors.lastname: McCance-Katz
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D019540:Area Under Curve; D003510:Cyclohexanes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D004347:Drug Interactions; D000431:Ethanol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D023581:HIV Fusion Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D008297:Male; D000077592:Maraviroc; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D003510:Cyclohexanes; D023581:HIV Fusion Inhibitors; D014230:Triazoles; D000431:Ethanol; D000077592:Maraviroc
keywords: HIV/AIDS; alcohol; drug interactions; maraviroc