title: β(3R3)-Peptides: design and synthesis of novel peptidomimetics and their self-assembling properties at the air-water interface.
abstract: In this study we present the design and synthesis of a novel class of peptidomimetics, the β(3R3)-peptides. Via alternating directions of the amide bonds along β-peptide sequences, β(3R3)-peptides can potentially extend the structural space available to β-peptidic foldamers. Detailed analysis at the air-water interface shows strand conformations and the formation of sheet assemblies with different degrees of crystallinity. Furthermore β(3R3)-peptides exhibit a high proteolytic stability thus making them an interesting new class of peptidomimetics for biomedical applications.
authors.affiliation: Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Mosca
authors.forename: Claudia
authors.initials: C
authors.lastname: Dannehl
authors.forename: Uwe
authors.initials: U
authors.lastname: Möginger
authors.forename: Gerald
authors.initials: G
authors.lastname: Brezesinski
authors.forename: Laura
authors.initials: L
authors.lastname: Hartmann
mesh_terms: D000388:Air; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry; D017433:Protein Structure, Secondary; D014867:Water / Q000737:chemistry*
chemical_list: D010455:Peptides; D057786:Peptidomimetics; D014867:Water