title: Malakoplakia in a healthy young female patient.
abstract: Malakoplakia is a rare granulomatous disease that occurs commonly in the urinary tract and secondarily in the gastrointestinal tract. Most reported cases of malakoplakia are associated with immunosuppressive diseases or chronic prolonged illness. Here, we report a rare case of malakoplakia in a young healthy adolescent without any underlying disease. A 19-year-old female was referred to our hospital following the discovery of multiple rectal polyps with sigmoidoscopy. She had no specific past medical history but complained of recurrent abdominal pain and diarrhea for 3 months. A colonoscopy revealed diverse mucosal lesions including plaques, polyps, nodules, and mass-like lesions. Histological examination revealed a sheet of histiocytes with pathognomonic Michaelis-Gutmann bodies. We treated the patient with ciprofloxacin, the cholinergic agonist bethanechol, and a multivitamin for 6 months. A follow-up colonoscopy revealed that her condition was resolved with this course of treatment.
authors.affiliation: Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Hyun
authors.forename: Hyun Deok
authors.initials: HD
authors.lastname: Shin
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018723:Bethanechol / Q000627:therapeutic use; D001706:Biopsy; D002939:Ciprofloxacin / Q000627:therapeutic use; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003108:Colonic Diseases / Q000175:diagnosis / Q000628:therapy; D003113:Colonoscopy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D008287:Malacoplakia / Q000175:diagnosis / Q000628:therapy; D018721:Muscarinic Agonists / Q000627:therapeutic use; D016896:Treatment Outcome; D014815:Vitamins / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D018721:Muscarinic Agonists; D014815:Vitamins; D018723:Bethanechol; D002939:Ciprofloxacin
keywords: Diverse mucosal lesions; Malakoplakia; Michaelis-Gutmann bodies