title: Curcumin inhibits lung cancer progression and metastasis through induction of FOXO1.
abstract: Recent population studies provide clues that the use of curcumin may be associated with reduced incidence and improved prognosis of certain cancers. In the present study, we demonstrated that curcumin acted as a growth inhibitor for lung cancer cells. Our results found that curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1. In addition, we showed that curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. These findings provide evidence for a mechanism that may contribute to the antineoplastic effects of curcumin and justify further work to explore potential roles for activators of FOXO1 in the prevention and treatment of lung cancer.
authors.affiliation: Department of Ultrasound, The First Affiliated Hospital, General Hospital of Chinese PLA, Beijing, 100048, China.
authors.forename: Zhen-Cai
authors.initials: ZC
authors.lastname: Li
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Zhang
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Wang
authors.forename: Jun-Xun
authors.initials: JX
authors.lastname: Ma
authors.forename: Jun-Zhong
authors.initials: JZ
authors.lastname: Sun
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D020935:MAP Kinase Signaling System / Q000187:drug effects; D009362:Neoplasm Metastasis
chemical_list: D000970:Antineoplastic Agents; D050759:Cyclin-Dependent Kinase Inhibitor p21; C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D019938:Cyclin D1; D050760:Cyclin-Dependent Kinase Inhibitor p27; D003474:Curcumin