title: Clinicopathological analysis of malignant eyelid tumours in north-west Pakistan.
abstract: OBJECTIVE
  To analyse the demography, mode of presentation, gross morphology, histopathological diagnosis and subsequent course of malignant eyelid tumours in north-west Pakistan.
  
  
  METHODS
  The retrospective observational study was performed at the Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, from January 2007 to July 2010, and comprised data related to 222 patients. Charts of patients with malignant eyelid tumours admitted to the department during study period were reviewed. Patients' demographic data, gross and microscopic features of the tumours and their subsequent course of treatments were recorded. SPSS 14 was used for statistical analysis.
  
  
  RESULTS
  Of the total, 122 (54.1%) patients were male and 102 (45.9%) were female. Mean age of all patients was 59.3 +/- 14.2 years. Among the patients, 73 (32.9%) had the involvement of the lower lid; 57 (25.7%) the upper lid; 18 (8.11%) the medial canthus; 2 (0.9%) the lateral canthus; and 72 (32.4%) had more than one region involved. On histopathology, basal cell carcinoma was the most common (n= 131; 59%), followed by squamous cell carcinoma in 70 (31.5%), sebaceous gland carcinoma in 15 (6.8%), malignant melanoma in 3 (1.3%) and undifferentiated carcinoma in 3 (1.3%) cases. Of the total tumours, 164 (73.87%) did not spread, and 58 (26.13%) spread either locally or distantly.
  
  
  CONCLUSIONS
  Basal cell carcinoma was is the most common malignant eyelid tumour in the study. Squamous cell carcinoma, which was second, was found to be more common in north-west Pakistan than in any other part of Asia, while the sebaceous gland carcinoma was relatively less common.
authors.affiliation: Department of Ophthalmology, KhyberTeaching Hospital, Peshawar, Pakistan. dribrar@hotmail.com
authors.forename: Ibrar
authors.initials: I
authors.lastname: Hussain
authors.forename: Fida Mohammad
authors.initials: FM
authors.lastname: Khan
authors.forename: Mumtaz
authors.initials: M
authors.lastname: Alam
authors.forename: Bakht Samar
authors.initials: BS
authors.lastname: Khan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D005142:Eyelid Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D010154:Pakistan; D012189:Retrospective Studies; D055815:Young Adult