title: Natural compounds containing mouthrinses in the management of dental plaque and gingivitis: a systematic review.
abstract: OBJECTIVE
  To evaluate the effectiveness of natural compounds containing mouthrinse (NCCM) as an adjunct to unsupervised oral hygiene in the management of dental plaque and gingivitis.
  
  
  METHODS
  An electronic search for clinical studies of NCCMs was conducted in Medline-PubMed, the Cochrane Central Register of Controlled Trials and EMBASE for a period spanning from the earliest available date in each database up to February 2013. Plaque index, gingival index, and gingival bleeding index were selected as primary outcomes. The methodological quality of the studies was assessed according to the "Levels of Evidence" outlined by the Center of Evidence-Based Medicine, and to the Jadad scale.
  
  
  RESULTS
  The screen yielded 2,236 titles and abstracts that met the inclusion criteria. These identified 11 clinical trials testing 13 different NCCMs, and were used for data extraction. Heterogeneity and the limited number of studies on any individual NCCM precluded a formal meta-analysis. Of the 13 NCCMs tested, eight demonstrated positive results, and few reported any adverse effects or events.
  
  
  CONCLUSIONS
  Evidence proving the effectiveness of NCCM as an adjunct to unsupervised oral hygiene for plaque and gingivitis control is still insufficient. However, some natural products (compounds) may have oral health benefits, so further high-quality study is warranted.
  
  
  CONCLUSIONS
  This review provides an overview of the strength of clinical evidence regarding the effectiveness of natural compounds containing mouthrinses in promoting gingival health.
authors.affiliation: Department of Orthodontics, Affiliated Stomatological Hospital of Fujian Medical University, Fujian, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Ricky W K
authors.initials: RW
authors.lastname: Wong
authors.forename: Colman
authors.initials: C
authors.lastname: McGrath
authors.forename: Urban
authors.initials: U
authors.lastname: Hagg
authors.forename: C Jayampath
authors.initials: CJ
authors.lastname: Seneviratne
mesh_terms: D001688:Biological Products / Q000009:adverse effects / Q000627:therapeutic use*; D003773:Dental Plaque / Q000188:drug therapy* / Q000517:prevention & control; D005891:Gingivitis / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D009067:Mouthwashes / Q000009:adverse effects / Q000627:therapeutic use*; D010512:Periodontal Index
chemical_list: D001688:Biological Products; D009067:Mouthwashes