title: Balance of power in host-virus arms races.
abstract: The sensing of viral RNA by the host innate immune system is mediated by RIG-I and its partner PACT. In this issue of Cell Host & Microbe, Luthra et al. (2013) show that the Ebola virus VP35 protein counteracts the action of PACT at the cost of compromising its own function in viral replication.
authors.affiliation: Department of Biochemistry and State Key Laboratory for Liver Research, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong.
authors.forename: Kin-Hang
authors.initials: KH
authors.lastname: Kok
authors.forename: Dong-Yan
authors.initials: DY
authors.lastname: Jin
mesh_terms: D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D029043:Ebolavirus / Q000378:metabolism*; D019142:Hemorrhagic Fever, Ebola / Q000378:metabolism*; D006801:Humans; D016601:RNA-Binding Proteins / Q000378:metabolism*; D011971:Receptors, Immunologic; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism*
chemical_list: C104647:PRKRA protein, human; D016601:RNA-Binding Proteins; D011971:Receptors, Immunologic; C080980:VP35 protein, filovirus; D054334:Viral Regulatory and Accessory Proteins; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases