title: Group Independent Component Analysis (gICA) and Current Source Density (CSD) in the study of EEG in ADHD adults.
abstract: OBJECTIVE
  To investigate the performance of the spectral analysis of resting EEG, Current Source Density (CSD) and group independent components (gIC) in diagnosing ADHD adults.
  
  
  METHODS
  Power spectra of resting EEG, CSD and gIC (19 channels, linked ears reference, eyes open/closed) from 96 ADHD and 376 healthy adults were compared between eyes open and eyes closed conditions, and between groups of subjects.
  
  
  RESULTS
  Pattern of differences in gIC and CSD spectral power between conditions was approximately similar, whereas it was more widely spatially distributed for EEG. Size effect (Cohen's d) of differences in gIC and CSD spectral power between groups of subjects was considerably greater than in the case of EEG. Significant reduction of gIC and CSD spectral power depending on conditions was found in ADHD patients. Reducing power in a wide frequency range in the fronto-central areas is a common phenomenon regardless of whether the eyes were open or closed.
  
  
  CONCLUSIONS
  Spectral power of local EEG activity isolated by gICA or CSD in the fronto-central areas may be a suitable marker for discrimination of ADHD and healthy adults.
  
  
  CONCLUSIONS
  Spectral analysis of gIC and CSD provides better sensitivity to discriminate ADHD and healthy adults.
authors.affiliation: N.P. Bechtereva Institute of the Human Brain of Russian Academy of Sciences, St. Petersburg, Russia. Electronic address: valery_ponomarev@mail.ru.
authors.forename: Valery A
authors.initials: VA
authors.lastname: Ponomarev
authors.affiliation: Brain and Trauma Foundation Grisons, Chur, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Mueller
authors.affiliation: Brain and Trauma Foundation Grisons, Chur, Switzerland.
authors.forename: Gian
authors.initials: G
authors.lastname: Candrian
authors.affiliation: N.P. Bechtereva Institute of the Human Brain of Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: Vera A
authors.initials: VA
authors.lastname: Grin-Yatsenko
authors.affiliation: N.P. Bechtereva Institute of the Human Brain of Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: Juri D
authors.initials: JD
authors.lastname: Kropotov
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D005123:Eye / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012146:Rest; D055815:Young Adult
keywords: ADHD; Current Source Density; EEG spectra; Group Independent Component Analysis