title: Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy.
abstract: OBJECTIVE
  To describe immunohistopathological findings in autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV).
  
  
  METHODS
  An enucleated eye specimen from a patient with Stage V ADNIV was examined using standard histopathological methods and lymphocyte markers.
  
  
  RESULTS
  A c.731T>C CAPN5 mutation resulted in a p.Leu244Pro substitution in calpain-5. The eye showed exudative retinal detachment and neovascularization, intraocular fibrosis, and features of phthisis bulbi. Chronic inflammatory CD3-positive cell infiltrates were identified throughout the uvea, vitreous and retina, consistent with chronic uveitis.
  
  
  CONCLUSIONS
  Mutations in CAPN5 trigger autoimmune uveitis characterized by inflammatory T-cells and severe neovascularization.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA ; Omics Laboratory, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
authors.forename: Vinit B
authors.initials: VB
authors.lastname: Mahajan
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Lin
keywords: ADNIV; CAPN5; CD3; autosomal dominant neovascular inflammatory vitreoretinopathy; uveitis