title: Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.
abstract: The relevance of claudin-6 and claudin-9 in hepatitis C virus (HCV) entry remains elusive. We produced claudin-6- or claudin-9-specific monoclonal antibodies that inhibit HCV entry into nonhepatic cells expressing exogenous claudin-6 or claudin-9. These antibodies had no effect on HCV infection of hepatoma cells or primary hepatocytes. Thus, although claudin-6 and claudin-9 can serve as entry factors in cell lines, HCV infection into human hepatocytes is not dependent on claudin-6 and claudin-9.
authors.affiliation: Inserm, U1110, Strasbourg, France.
authors.forename: Isabel
authors.initials: I
authors.lastname: Fofana
authors.forename: Laetitia
authors.initials: L
authors.lastname: Zona
authors.forename: Christine
authors.initials: C
authors.lastname: Thumann
authors.forename: Laura
authors.initials: L
authors.lastname: Heydmann
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Durand
authors.forename: Joachim
authors.initials: J
authors.lastname: Lupberger
authors.forename: Hubert E
authors.initials: HE
authors.lastname: Blum
authors.forename: Patrick
authors.initials: P
authors.lastname: Pessaux
authors.forename: Claire
authors.initials: C
authors.lastname: Gondeau
authors.forename: Gary M
authors.initials: GM
authors.lastname: Reynolds
authors.forename: Jane A
authors.initials: JA
authors.lastname: McKeating
authors.forename: Fritz
authors.initials: F
authors.lastname: Grunert
authors.forename: John
authors.initials: J
authors.lastname: Thompson
authors.forename: Mirjam B
authors.initials: MB
authors.lastname: Zeisel
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Baumert
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D002478:Cells, Cultured; D057167:Claudins / Q000378:metabolism*; D016174:Hepacivirus / Q000502:physiology*; D022781:Hepatocytes / Q000821:virology*; D006801:Humans; D053586:Virus Internalization
chemical_list: D000911:Antibodies, Monoclonal; C524757:CLDN9 protein, human; D057167:Claudins; C122101:claudin 6