title: Generation and characterization of a new solid form of trehalose.
abstract: We have identified and characterized a new solid form of trehalose, the δ form (Tδ) using (13)C solid-state NMR spectroscopy (SSNMR). Tδ is formed from dehydrations of trehalose dihydrate (T(h)) performed at or below 100 °C, and it is generated concurrently with the α form of trehalose (Tα) and amorphous trehalose (T(am)); the β form of trehalose (Tβ) has been observed in some dehydrated samples. Differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD) studies of samples containing Tδ do not indicate the presence of the new form. Tδ is metastable: upon exposure to temperatures above 80 °C, it converts to either Tα or Tam, and upon exposure to ambient humidity, it reverts to T(h).
authors.affiliation: Department of Pharmaceutical Sciences, University of Kentucky , Lexington, Kentucky 40536, United States.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Pyszczynski
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Munson
mesh_terms: D002152:Calorimetry, Differential Scanning; D009682:Magnetic Resonance Spectroscopy; D013696:Temperature; D014199:Trehalose / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D014199:Trehalose