title: Gluten ataxia of sporadic and hereditary cerebellar ataxia in patients from mainland China.
abstract: BACKGROUND
  Gluten sensitivity (GS) is a spectrum of disorders with diverse manifestations. Recent evidence suggests that ataxia may be the only manifestation of GS and that it may be one of the causes of sporadic ataxia.
  
  
  OBJECTIVE
  To investigate the prevalence of gluten ataxia among patients with ataxia in China.
  
  
  METHODS
  Serum levels of anti-gliadin, anti-transglutaminase 2 (TG2), and anti-transglutaminase 6 (TG6) antibodies measured in 125 patients with ataxia (100 patients with sporadic ataxia and 25 patients with hereditary ataxia) and 51 healthy controls by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The serum concentrations of anti-gliadin, anti-TG2 IgG, IgA, and TG6-IgG antibodies were elevated in ataxia patients, but the increase was not statistically significant. However, TG6-IgA serum levels were significantly higher in sporadic ataxia as compared to those in healthy controls (P < 0.05).
  
  
  CONCLUSIONS
  These results provide evidence that sporadic ataxia in a subgroup of patients may be due to gluten ataxia in mainland China. Measurement of serum anti-TG6 antibodies along with anti-TG2 and anti-gliadin antibodies may be useful for diagnosing gluten ataxia.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Guan
authors.forename: Xin-Jian
authors.initials: XJ
authors.lastname: Liu
authors.forename: Bei-Sha
authors.initials: BS
authors.lastname: Tang
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Lu
authors.initials: L
authors.lastname: Shen
authors.forename: Kun
authors.initials: K
authors.lastname: Xia
authors.forename: Jun-Ling
authors.initials: JL
authors.lastname: Wang
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000097:blood / Q000150:complications / Q000276:immunology*; D002524:Cerebellar Ataxia / Q000097:blood / Q000209:etiology / Q000276:immunology*; D002681:China; D005260:Female; D005903:Gliadin / Q000009:adverse effects / Q000276:immunology; D005983:Glutens / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013132:Spinocerebellar Degenerations / Q000097:blood / Q000276:immunology*; D011503:Transglutaminases / Q000276:immunology*
chemical_list: D005983:Glutens; D005903:Gliadin; C532876:TGM6 protein, human; D011503:Transglutaminases