title: Genomics in clinical practice: lessons from the front lines.
abstract: The price of whole-genome and -exome sequencing has fallen to the point where these methods can be applied to clinical medicine. Here, we outline the lessons we have learned in converting a sequencing laboratory designed for research into a fully functional clinical program.
authors.affiliation: Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. jacob@mcw.edu
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Jacob
authors.forename: Kelly
authors.initials: K
authors.lastname: Abrams
authors.forename: David P
authors.initials: DP
authors.lastname: Bick
authors.forename: Kent
authors.initials: K
authors.lastname: Brodie
authors.forename: David P
authors.initials: DP
authors.lastname: Dimmock
authors.forename: Michael
authors.initials: M
authors.lastname: Farrell
authors.forename: Jennifer
authors.initials: J
authors.lastname: Geurts
authors.forename: Jeremy
authors.initials: J
authors.lastname: Harris
authors.forename: Daniel
authors.initials: D
authors.lastname: Helbling
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Joers
authors.forename: Robert
authors.initials: R
authors.lastname: Kliegman
authors.forename: George
authors.initials: G
authors.lastname: Kowalski
authors.forename: Jozef
authors.initials: J
authors.lastname: Lazar
authors.forename: David A
authors.initials: DA
authors.lastname: Margolis
authors.forename: Paula
authors.initials: P
authors.lastname: North
authors.forename: Jill
authors.initials: J
authors.lastname: Northup
authors.forename: Altheia
authors.initials: A
authors.lastname: Roquemore-Goins
authors.forename: Gunter
authors.initials: G
authors.lastname: Scharer
authors.forename: Mary
authors.initials: M
authors.lastname: Shimoyama
authors.forename: Kimberly
authors.initials: K
authors.lastname: Strong
authors.forename: Bradley
authors.initials: B
authors.lastname: Taylor
authors.forename: Shirng-Wern
authors.initials: SW
authors.lastname: Tsaih
authors.forename: Michael R
authors.initials: MR
authors.lastname: Tschannen
authors.forename: Regan L
authors.initials: RL
authors.lastname: Veith
authors.forename: Jaime
authors.initials: J
authors.lastname: Wendt-Andrae
authors.forename: Brandon
authors.initials: B
authors.lastname: Wilk
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Worthey
mesh_terms: D003657:Decision Making; D023281:Genomics / Q000191:economics; D006801:Humans; D010818:Practice Patterns, Physicians'; D017422:Sequence Analysis, DNA; D057170:Translational Research, Biomedical / Q000191:economics