title: Electrogenerated chemiluminescence of novel TiO2/CdS nanocomposites for sensitive assays of cancer cells.
abstract: A novel TiO2/CdS nanocomposite was prepared and used to fabricate an electrochemiluminescence (ECL) biosensor for the detection of cancer cells for the first time. The nanocomposite exhibited a strong cathodic ECL signal. Folic acid for targeting cell membranes was bound to a TiO2/CdS/3-aminopropyltriethoxysilane film, and specific recognition of folic acid to targeting cells was achieved, leading to a significant decrease in ECL intensity. The decrease in ECL signal was logarithmically related to the cell concentration in the range of 150-9600 cells mL(-1). The ECL biosensor could provide a sensitive, selective, and convenient approach for early and accurate detection of cancer cells.
authors.affiliation: Linyi University, Linyi 276000, Shandong, People's Republic of China. Electronic address: kuaijixue2008b@163.com.
authors.forename: Tingyu
authors.initials: T
authors.lastname: Huang
authors.forename: Guifen
authors.initials: G
authors.lastname: Jie
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D055664:Electrochemical Techniques; D006801:Humans; D049449:Luminescence; D015394:Molecular Structure; D053761:Nanocomposites / Q000737:chemistry*; D009369:Neoplasms / Q000473:pathology*; D013440:Sulfides / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D013440:Sulfides; C034939:cadmium sulfide; C009495:titanium dioxide; D014025:Titanium
keywords: Electrochemiluminescence biosensor; TiO(2)/CdS nanocomposites