title: Automatic assessment of stent neointimal coverage by intravascular optical coherence tomography.
abstract: OBJECTIVE
  This study aimed to validate automatic intravascular optical coherence tomography (IVOCT) analysis for the evaluation of neointimal coverage in response to stent implantation.
  
  
  RESULTS
  Fourteen stented segments in common iliac arteries, acquired from a total of seven adult male New Zealand White rabbits, were interrogated in vivo by IVOCT. Durable polymer everolimus-eluting stents (EES; Xience V, Abbott Vascular, Santa Clara, CA, USA) were used exclusively. Comparison with histology was made in a total of 63 pairs of images, where neointimal thickness over corresponding individual stent struts was assessed. A high correlation coefficient (R = 0.85, P < 0.001) was obtained by comparing automatic IVOCT analysis with histology. Moreover, Bland-Altman statistics showed good limits of agreement (LOAs) of ±45 µm, with an average difference of -10 µm. In addition, manual IVOCT assessment presented very similar results when compared with histology (R = 0.83, P < 0.001 and LOA = ±48 µm with an average difference of -8 µm). Therefore, a very high correlation value was found, comparing manual to automatic IVOCT measurements (R = 0.95, P < 0.001) together with good LOAs (±27 µm) and an average difference of -2 µm.
  
  
  CONCLUSIONS
  The results of the study suggest that automatic IVOCT analysis is a reliable and accurate tool able to speed up current IVOCT analysis procedures. This would potentially allow for a better integration of IVOCT in clinical practice and clinical studies assessing vascular response to stent implantation in a large series of patients.
authors.affiliation: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
authors.forename: Giovanni J
authors.initials: GJ
authors.lastname: Ughi
authors.forename: Christophe J
authors.initials: CJ
authors.lastname: Van Dyck
authors.forename: Tom
authors.initials: T
authors.lastname: Adriaenssens
authors.forename: Vicky Y
authors.initials: VY
authors.lastname: Hoymans
authors.forename: Peter
authors.initials: P
authors.lastname: Sinnaeve
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Timmermans
authors.forename: Walter
authors.initials: W
authors.lastname: Desmet
authors.forename: Christiaan J
authors.initials: CJ
authors.lastname: Vrints
authors.forename: Jan
authors.initials: J
authors.lastname: D'hooge
mesh_terms: D000818:Animals; D054855:Drug-Eluting Stents; D007083:Iliac Artery / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D008297:Male; D023421:Models, Animal; D058426:Neointima / Q000473:pathology*; D011817:Rabbits; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: OCT; image analysis; neointimal coverage; optical coherence tomography; stent