title: Chromonychia secondary to chemotherapy.
abstract: Chemotherapy drugs can affect the skin and its appendages. Several clinical presentations can be observed, depending on the affected structure. The most common dermatological side effect is chromonychia. The main causative agents are: (1) cyclophosphamide, which can provoke a diffuse, black pigmentation, longitudinal striae and dark grey pigmentation located proximally on the nails; (2) doxorubicin, which promotes dark brown bands alternating with white striae and dark brown pigmentation in transverse bands, and (3) hydroxyurea, which produces a distal, diffuse, dark brown pigmentation. In the majority of cases, the effects are reversible after the suspension of the causative agent for a few months. We report a patient who developed chromonychia while undergoing treatment with cyclophosphamide, vincristine, doxorubicin, dexamethasone, methotrexate and cytarabine for acute lymphocytic leukemia.
authors.affiliation: Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Marien
authors.initials: M
authors.lastname: Lopes
authors.forename: Clarice
authors.initials: C
authors.lastname: Jordão
authors.forename: Rachel
authors.initials: R
authors.lastname: Grynszpan
authors.forename: Celso
authors.initials: C
authors.lastname: Sodré
authors.forename: Marcia
authors.initials: M
authors.lastname: Ramos-E-Silva
keywords: Chemotherapy; Chromonychia; Cyclophosphamide; Doxorubicin; Hydroxyurea