title: Immunity against selected piscine flagellates.
abstract: This discussion is on immune response to Amyloodinium ocellatum, Cryptobia salmositica, Trypanoplasma borreli and Trypanosoma carassii. Piscidin and histone-like proteins enhance innate resistance to Amyloodinium. Fish that are naturally resistant to Cryptobia and Trypanoplasma can be bred. Cryptobia resistance in charr is controlled by a dominant Mendelian locus and protection is via the Alternative Pathway of Complement Activation. Studies on Cryptobia-tolerant charr may lead to production of transgenic Cryptobia-tolerant salmon. Innate response to T. borreli is associated with NO in macrophages. Transferrin regulates resistance and carp have been bred for transferrin genotypes. Recovered fish are protected from homologous challenge, and complement fixing antibodies are crucial in protection. Studies on antigens in T. carassii may lead to a vaccine. There are two vaccines against cryptobiosis; a single dose of the attenuated vaccine protects salmonids. On challenge fish inoculated with the metalloprotease-DNA vaccine do not have the disease and they recover faster.
authors.affiliation: Department of Integrative Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address: pwoo@uoguelph.ca.
authors.forename: Patrick T K
authors.initials: PT
authors.lastname: Woo
authors.affiliation: Department of Biology, Brandon University, Brandon, Manitoba R7A 6A9, Canada. Electronic address: ardellib@brandonu.ca.
authors.forename: Bernadette F
authors.initials: BF
authors.lastname: Ardelli
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D003170:Complement Pathway, Alternative / Q000235:genetics; D004198:Disease Susceptibility; D029941:Fish Proteins / Q000378:metabolism; D005399:Fishes / Q000276:immunology*; D005407:Flagella / Q000378:metabolism*; D007113:Immunity, Innate; D014168:Transferrin / Q000378:metabolism; D014345:Trypanosoma / Q000276:immunology*; D014352:Trypanosomiasis / Q000276:immunology*; D014612:Vaccines
chemical_list: D023181:Antimicrobial Cationic Peptides; D029941:Fish Proteins; D014168:Transferrin; D014612:Vaccines; C449802:moronecidin protein, Morone saxatilis
keywords: Amyloodinium ocellatum; Cryptobia salmositica; Fish; Immune response; Trypanoplasma borreli; Trypanosoma carassii