title: Recreational use of 1-(2-naphthyl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride (NRG-1), 6-(2-aminopropyl) benzofuran (benzofury/ 6-APB) and NRG-2 with review of available evidence-based literature.
abstract: OBJECTIVE
  This study aimed to review the available evidence-based literature on novel psychoactive substances and to inform health care professionals.
  
  
  METHODS
  Internet searches were carried out using Google and Yahoo by using specific key words. For each set of key words, the first 100 websites identified by Google and Yahoo were fully assessed, together with a further 5% of random samples selected by research randomizer of the remaining websites. Thus, a list of unique web forums was identified, and qualitative information was extracted. Available evidence-based literature were reviewed along with a user's experimentation with mephedrone, NRG-1, NRG-2 and Benzofury.
  
  
  RESULTS
  It showed that when a substance (mephedrone) became controlled, the vendors aggressively promote the sale of other new compounds (NRG-1, NRG-2, Benzofury) to attract vulnerable adults. The characteristics, toxicity and suggested management of these new compounds (NRG-1, NRG-2, Benzofury) are discussed.
  
  
  CONCLUSIONS
  The arrival of hundreds of novel psychoactive substances for sale online has raised a number of public health and legal issues. Although evidence-based literature remains limited, few studies identified that most products do not contain the ingredients as advertised. Better levels of international cooperation and rapid share of available information may be needed to tackle this emerging problem.
authors.affiliation: Specialty Registrar-ST6, ABM University Health Board, Swansea, UK. drjeshur@gmail.com
authors.forename: Jeshoor
authors.initials: J
authors.lastname: Jebadurai
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Schifano
authors.forename: Paolo
authors.initials: P
authors.lastname: Deluca
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010259:Paranoid Disorders / Q000139:chemically induced / Q000175:diagnosis; D010422:Pentanones / Q000009:adverse effects* / Q000737:chemistry; D011437:Propylamines / Q000009:adverse effects* / Q000737:chemistry; D011759:Pyrrolidines / Q000009:adverse effects* / Q000737:chemistry; D011897:Random Allocation; D013610:Tachycardia / Q000139:chemically induced / Q000175:diagnosis
chemical_list: C509270:1-naphthalen-2-yl-2-pyrrolidin-1-ylpentan-1-one; D001572:Benzofurans; D013287:Illicit Drugs; D010422:Pentanones; D011437:Propylamines; D011759:Pyrrolidines; C587038:6-(2-aminopropyl)benzofuran
keywords: Benzofury; NRG-1; NRG-2; legal highs; novel psychoactive substances