title: Cerebrospinal fluid biomarkers in Alzheimer's disease, vascular dementia and ischemic stroke patients: a critical analysis.
abstract: Vascular factors are thought to contribute to the development of disease pathology in neurodegenerative dementia such as Alzheimer's disease (AD). Another entity, called vascular dementia (VaD), comprises a less defined group of dementia patients having various vascular diseases that especially emerge in the elderly population and require valid options for examination and differential diagnosis. In the context of a retrospective study, we analyzed the cerebrospinal fluid (CSF) biomarkers t-tau, p-tau and Aß42 of a total of 131 patients with AD (n = 47), mild cognitive impairment (MCI) (n = 22), VaD (n = 44) and stroke (n = 18). We found a remarkable alteration in CSF biomarker profile in AD, VaD and in acute ischemic events. CSF profile in AD patients was altered in a very similar way as in stroke patients, without statistical differences. In stroke, increase depend largely on size and duration after the initial event. Total tau levels were useful to differ between VaD and stroke. Aß42 decreased in a similar way in AD, VaD and stroke and had a trend to lower levels in MCI but not in controls.
authors.affiliation: Department of Neurology, Clinical Dementia Center, University Medical Center, Georg August University Göttingen, Göttingen, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Kaerst
authors.forename: Andre
authors.initials: A
authors.lastname: Kuhlmann
authors.forename: Dirk
authors.initials: D
authors.lastname: Wedekind
authors.forename: Katharina
authors.initials: K
authors.lastname: Stoeck
authors.forename: Peter
authors.initials: P
authors.lastname: Lange
authors.forename: Inga
authors.initials: I
authors.lastname: Zerr
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D002545:Brain Ischemia / Q000150:complications; D060825:Cognitive Dysfunction / Q000134:cerebrospinal fluid; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D020521:Stroke / Q000134:cerebrospinal fluid* / Q000209:etiology; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins