title: Comparison of cranial magnetic resonance imaging findings and clinical features in patients with corpus callosum abnormalities.
abstract: OBJECTIVE
  The aim of this study was to evaluate the relationship between clinical and cranial magnetic resonance imaging findings in patients with corpus callosum (CC) abnormalities.
  
  
  METHODS
  Between September 2010 and March 2012, patients with developmental CC abnormalities were included in the study. CC abnormalities were classified as total agenesis, partial agenesis, and callosal hypoplasia. Regarding the groups, the association between radiological abnormalities and clinical findings were evaluated.
  
  
  RESULTS
  A total of 62 patients (32 females [51.6%] and 30 males [48.4%]) with a mean age of 18.0 ± 32.1 months were enrolled in the study. Of them, 20 patients (32.3%) had total agenesis, 9 patients (14.5%) had partial agenesis, and 33 (53.2%) patients had hypoplasia of the CC. Thirty-five cases (56.7%) had abnormal physical examination, 47 cases (75.8%) had abnormal neurological examination, and 42 cases (67.7%) had psychomotor retardation. There were no significant differences between groups regarding physical examination, psychomotor retardation, seizures, or microcephaly. Seizures, psychomotor retardation, and neurological abnormalities were significantly more frequent in patients with associated other radiological abnormalities. Posterior segment of the CC was significantly thinner in patients with psychomotor retardation and the anterior part of the CC thinner in patients with abnormal physical examination. Patients with total agenesis were more prone to seizures at an early age than patients with partial agenesis or hypoplasia.
  
  
  CONCLUSIONS
  The neurological prognosis of patients with CC abnormalities is poorer in patients with an associated neuroradiological abnormality. Early development of seizures may be observed in cases with total agenesis of the CC.
authors.affiliation: Division of Pediatric Neurology, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Bayram
authors.affiliation: Division of Pediatric Neurology, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Topcu
authors.affiliation: Division of Pediatric Neurology, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Uluc
authors.initials: U
authors.lastname: Yis
authors.affiliation: Department of Radiology, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Cakmaci
authors.affiliation: Division of Pediatric Neurology, Dokuz Eylul University Hospital, Izmir, Turkey.
authors.forename: Semra Hiz
authors.initials: SH
authors.lastname: Kurul
mesh_terms: D061085:Agenesis of Corpus Callosum / Q000145:classification / Q000175:diagnosis / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D010808:Physical Examination; D011859:Radiography