title: Fear-enhancing effects of septal oxytocin receptors.
abstract: The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic, prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently emerged. Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of Oxtr. These effects emerge after social defeat and require Oxtr specifically coupled to the extracellular signal-regulated protein kinase pathway.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois, USA.
authors.forename: Yomayra F
authors.initials: YF
authors.lastname: Guzmán
authors.forename: Natalie C
authors.initials: NC
authors.lastname: Tronson
authors.forename: Vladimir
authors.initials: V
authors.lastname: Jovasevic
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sato
authors.forename: Anita L
authors.initials: AL
authors.lastname: Guedea
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mizukami
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Nishimori
authors.forename: Jelena
authors.initials: J
authors.lastname: Radulovic
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002070:Butadienes / Q000494:pharmacology; D050882:CREB-Binding Protein / Q000378:metabolism; D005239:Fear; D049452:Green Fluorescent Proteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009570:Nitriles / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism; D011506:Proteins / Q000235:genetics; D022661:RNA, Untranslated; D018045:Receptors, Oxytocin / Q000235:genetics / Q000378:metabolism*; D020665:Septum of Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D012919:Social Behavior; D013315:Stress, Psychological / Q000150:complications; D014161:Transduction, Genetic; D014668:Vasotocin / Q000494:pharmacology
chemical_list: D002070:Butadienes; C110853:Gt(ROSA)26Sor non-coding RNA, mouse; D009570:Nitriles; C576074:OXTR protein, mouse; D011506:Proteins; D022661:RNA, Untranslated; D018045:Receptors, Oxytocin; C113580:U 0126; D049452:Green Fluorescent Proteins; D010121:Oxytocin; D050882:CREB-Binding Protein; D011493:Protein Kinase C; D048052:Mitogen-Activated Protein Kinase 3; D014668:Vasotocin