title: Desymmetrization of 4,6-diprotected myo-inositol.
abstract: The asymmetric desymmetrization of 4,6-diprotected myo-inositol derivatives was achieved by using a bifunctional, readily available nucleophilic catalyst. The orthogonally protected products were obtained in 80-99% yield with 90-99% ee. Such structures serve as potential enantiopure building blocks for the synthesis of myo-inositol phosphates.
authors.affiliation: Karlsruhe Institute of Technology, Institute for Organic Chemistry, Fritz-Haber Weg 6, Germany.
authors.forename: Markus B
authors.initials: MB
authors.lastname: Lauber
authors.forename: Constantin-Gabriel
authors.initials: CG
authors.lastname: Daniliuc
authors.forename: Jan
authors.initials: J
authors.lastname: Paradies
mesh_terms: D002384:Catalysis; D007294:Inositol / Q000031:analogs & derivatives*; D007295:Inositol Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007295:Inositol Phosphates; D007294:Inositol