title: Revealing the anti-tumoral effect of Algerian Glaucium flavum roots against human cancer cells.
abstract: Glaucium flavum (G. flavum) is a plant from the Papaveraceae family native to Algeria where it is used in local traditional medicine to treat warts. G. flavum root crude alkaloid extract inhibited breast cancer cell proliferation and induced G2/M phase cycle arrest and apoptosis without affecting normal cells, which is a highly awaited feature of potential anti-cancer agents. G. flavum significantly reduced growth and vascularization of human glioma tumors on chicken chorioallantoic membrane (CAM) in vivo. The chromatographic profile of the dichloromethane extract of G. flavum root showed the presence of different constituents including the isoquinoline alkaloid protopine, as the major compound. We report for the first time that G. flavum extract may represent a new promising agent for cancer chemotherapy.
authors.affiliation: Laboratory of Plant Biotechnology and Ethnobotany, Faculty of Natural Sciences and Life, University of Bejaia, Bejaia, Algeria; Metastasis Research Laboratory, GIGA-Cancer, University of Liege, Liege, Belgium; Laboratory of Pharmacognosy, CIRM, University of Liege, Liege, Belgium.
authors.forename: Lamine
authors.initials: L
authors.lastname: Bournine
authors.forename: Sihem
authors.initials: S
authors.lastname: Bensalem
authors.forename: Paul
authors.initials: P
authors.lastname: Peixoto
authors.forename: Arnaud
authors.initials: A
authors.lastname: Gonzalez
authors.forename: Fadila
authors.initials: F
authors.lastname: Maiza-Benabdesselam
authors.forename: Fatiha
authors.initials: F
authors.lastname: Bedjou
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Wauters
authors.forename: Monique
authors.initials: M
authors.lastname: Tits
authors.forename: Michel
authors.initials: M
authors.lastname: Frédérich
authors.forename: Vincent
authors.initials: V
authors.lastname: Castronovo
authors.forename: Akeila
authors.initials: A
authors.lastname: Bellahcène
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D015394:Molecular Structure; D028101:Papaveraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D010936:Plant Extracts
keywords: Apoptosis; Breast cancer; Cell cycle arrest; Glaucium flavum; Growth inhibition