title: [Phyllodes tumor of the breast: clinicopathologic analysis of 22 cases].
abstract: BACKGROUND
  Phyllodes tumors of the breast are uncommon fibroepithelial neoplasms that have potential for recurrence. They are classified as benign, borderline, and malignant, based on a constellation of histologic characteristics that includes the degree of stromal hypercellularity, cytologic atypia and mitotic activity.
  
  
  OBJECTIVE
  To analyze the clinical and pathological features of 22 women treated at a referral center in Mexico City.
  
  
  METHODS
  We performed a retrospective analysis of women with phyllodes tumors of the breast treated at our institution between 1998 and 2011. Age, tumor size, surgical method, stromal cellular atypia, mitotic activity, stromal overgrowth, histological classification and surgical margin status were analyzed to determine their possible association with tumor recurrence.
  
  
  RESULTS
  Mean patient age at presentation was 42 years. Ten of them (43.5%) had late menarche. Six patients (27.27%) used hormones. Twenty patients (91%) had tumor detected by self-examination. Mean size of the lesion was 7.4 cm. Most lesions were located in the upper outer quadrant (77.3%) and in the left breast (59.1%). Fourteen patients (63.6%) were treated with conservative surgery. Three patients (13.6%) presented local recurrence, two as benign tumors and one patient with two recurrences, first as benign tumor thereafter as malignant phyllodes tumor at 72 and 108 months respectively.
  
  
  CONCLUSIONS
  . In our study, surgical positive margin status is the main prognostic factor for recurrence.
authors.affiliation: Facultad de Medicina, Benemérita Universidad Autónoma de Puebla.
authors.forename: Magalie
authors.initials: M
authors.lastname: Velázquez-Dohorn
authors.forename: Armando
authors.initials: A
authors.lastname: Gamboa-Domínguez
authors.forename: Heriberto
authors.initials: H
authors.lastname: Medina-Franco
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008080:Liposarcoma / Q000473:pathology; D008408:Mastectomy / Q000379:methods; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D003557:Phyllodes Tumor / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000473:pathology; D055815:Young Adult