title: Structural characterization and thermal and chemical stability of bioactive molecule-hydrotalcite (LDH) nanocomposites.
abstract: Layered double hydroxides (LDH) are versatile materials used for intercalating bioactive molecules, both in pharmaceutical and cosmetic fields, with the purpose of protecting them from degradation, enhancing their water solubility to increase bioavailability, and/or obtaining modified release properties. The properties of the intercalation compounds of Mg/Al_LDH and Zn/Al_LDH with different drugs and sunscreens, namely diclofenac, ketoprofen, gliclazide, retinoic acid, furosemide, para-aminobenzoic acid and 2-phenylbenzimidazolsulfonic (Eusolex) acid, have been studied by crystallographic, spectroscopic and thermogravimetric techniques and by solid state NMR, to shed light on their structure, their molecular interactions and their stability from the thermal and chemical viewpoint. The structural features were described with particular attention to the interaction between the organic and inorganic components and to the stability of the intercalation products. For the first time two synchrotron radiation powder diffraction patterns of organic-containing LDH were solved and refined by Rietveld methods to obtain an experimental crystal structure.
authors.affiliation: Dipartimento di Scienze e Innovazione Tecnologica and Nano-SiSTeMI Interdisciplinary Centre, Università del Piemonte Orientale A. Avogadro (Italy), Via Michel 11, I-15121 Alessandria, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Conterosito
authors.forename: Gianluca
authors.initials: G
authors.lastname: Croce
authors.forename: Luca
authors.initials: L
authors.lastname: Palin
authors.forename: Cinzia
authors.initials: C
authors.lastname: Pagano
authors.forename: Luana
authors.initials: L
authors.lastname: Perioli
authors.forename: Davide
authors.initials: D
authors.lastname: Viterbo
authors.forename: Enrico
authors.initials: E
authors.lastname: Boccaleri
authors.forename: Geo
authors.initials: G
authors.lastname: Paul
authors.forename: Marco
authors.initials: M
authors.lastname: Milanesio
mesh_terms: D000536:Aluminum Hydroxide / Q000737:chemistry*; D008276:Magnesium Hydroxide / Q000737:chemistry*; D015394:Molecular Structure; D053761:Nanocomposites / Q000737:chemistry*; D013696:Temperature
chemical_list: C010467:hydrotalcite; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide