title: Cytoprotective, antihyperglycemic and phytochemical properties of Cocos nucifera (L.) inflorescence.
abstract: OBJECTIVE
  To analyze the cytoprotective and antidiabetic activities as well as phytochemical composition of the immature inflorescence of Cocos nucifera belonging to the Arecaceae Family.
  
  
  METHODS
  The phytochemical screening of inflorescence was done to determine the major constituents present in Cocos nucifera inflorescence. The free radical scavenging potential of inflorescence extracts were evaluated using in vitro radical scavenging assay models.
  
  
  RESULTS
  The phytochemical analyses on inflorescence showed the presence of phenolic compounds, flavonoids, resins and alkaloids. The macronutrient analyses, on the other hand, showed the presence of carbohydrate, proteins and fibers. Administration of the methanol extract of coconut inflorescence to the diabetic rats showed dose dependent reduction in hyperglycemia. The cytoprotective property of coconut inflorescence was evidenced from the acute toxicological evaluation. The levels of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were significantly decreased in the diabetic rats treated with inflorescence when compared with the diabetic control rats.
  
  
  CONCLUSIONS
  The results obtained from the present study apparently proved the non-toxic nature and the cytoprotective and antihyperglycemic properties of coconut inflorescence.
authors.affiliation: Department of Biochemistry, University of Kerala, Thiruvananthapuram-695581, Kerala, India.
authors.forename: R S
authors.initials: RS
authors.lastname: Renjith
authors.forename: A M
authors.initials: AM
authors.lastname: Chikku
authors.forename: T
authors.initials: T
authors.lastname: Rajamohan
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003059:Cocos / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry*; D056626:Inflorescence / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry*; D020011:Protective Agents / Q000008:administration & dosage / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts; D020011:Protective Agents; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Antihyperglycemic; Coconut inflorescence; Cytoprotective property; Phenolic compound; Phytochemical; Streptozotocin