title: [Primary nasopharyngeal tuberculosis].
abstract: A 59-year-old female was complaining of sore throat, right otorrhea, and hearing impairment. There were no abnormal findings suggestive of pulmonary tuberculosis on her chest XP and CT. Nasopharyngoscopic examination detected a lesion coated with white mass on her nasopharynx, and a biopsy-specimen from this lesion revealed histopathological findings compatible with tuberculosis and the presence of acid-fast bacilli. PCR was positive for Mycobacterium tuberculosis complex. Therefore, we diagnosed the case as primary nasopharyngeal tuberculosis and treated her by 4-drug combination regimen with daily isoniazid, rifampicin, ethambutol and pyrazinamide. Later, low degree of resistance was noticed, isoniazid was replaced by levofloxacin. After the anti-tuberculosis chemotherapy, her symptoms almost completely diminished and the mass in her nasopharynx disappeared. As far as we can search, 23 Japanese cases of primary nasopharyngeal tuberculosis, including this case, have been reported in the literatures. We summarized the clinical features of these cases in Table. Nasopharyngeal tuberculosis is a rather rare disease. But, recently, due to the advances in diagnostic technology, the number of the case-reports has been increasing. Difficulties in detecting tubercle bacilli in nasopharyngeal lesion sometimes delayed definite diagnosis and treatment. If a patient complains the symptoms compatible with this disease, such as sore throat, pharyngeal pain and otorrhea, which are refractory to the general antibiotic therapy, we should be aware of the existence of this disease and repeat bacteriological and/or molecular examinations to prove tubercle bacilli to be able to start timely anti-tuberculosis chemotherapy.
authors.affiliation: Department of Respiratory Medicine, Osaka City Juso Hospital, 2-12-27, Nonaka-kita, Yodogawa-ku, Osaka-shi, Osaka 532-0034, Japan. ay-takagi@hospital.city.osaka.jp
authors.forename: Ayaka
authors.initials: A
authors.lastname: Takagi
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Nagayasu
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Sugama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shiraishi
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D009302:Nasopharyngeal Diseases / Q000175:diagnosis* / Q000188:drug therapy; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy