title: Could torasemide be a prophylactic agent of contrast induced acute kidney injury? A review about this field.
abstract: Contrast Induced Acute Kidney Injury (CI-AKI), due to the use of contrast media in radiographic procedures, is the leading cause of acute renal failure in hospitalized patients, and is associated with prolonged in-hospital stay and increased morbidity, mortality, and costs. However only peri-procedural hydration is now used universally as its preventive strategy. Some studies indicates that renin-angiotensin-aldosterone system (RAAS) is possibly responsible for the development of contrast-induced nephrotoxicity through mediating abnormalities of renal perfusion and other mechanisms. And torasemide, known as loop diuretics, could inhibit RAAS through its anti-aldosteronergic function. Therefore, speculation about torasemide's prevention of CI-AKI could be firmly made. Intravenously administrated torasemide would be promising as a future prophylactic agent, possibly in combination with other strategies such as adequate peri-procedural hydration and other renal protective agents, in the prevention of CI-AKI. In this context, we review the background and the role of RAAS on the development of CI-AKI, and discuss the pharmacologic individuality of torasemide on RAAS and torasemide's preventive effect on CI-AKI.
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: X-M
authors.initials: XM
authors.lastname: Li
authors.forename: D-X
authors.initials: DX
authors.lastname: Jin
authors.forename: H-L
authors.initials: HL
authors.lastname: Cong
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced* / Q000517:prevention & control*; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D004232:Diuretics / Q000627:therapeutic use*; D006801:Humans; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D013449:Sulfonamides / Q000627:therapeutic use*; D000077786:Torsemide
chemical_list: D003287:Contrast Media; D004232:Diuretics; D013449:Sulfonamides; D000077786:Torsemide