title: Emetic potentials of newly identified staphylococcal enterotoxin-like toxins.
abstract: Staphylococcal enterotoxins (SEs) are a common causative agent of food poisoning. Recently, many new SE-like (SEl) toxins have been reported, although the role of SEls in food poisoning remains unclear. In this study, the emetic potentials of SElK, SElL, SElM, SElN, SElO, SElP, and SElQ were assessed using a monkey-feeding assay. All the SEls that were tested induced emetic reactions in monkeys at a dose of 100 μg/kg, although the numbers of affected monkeys were significantly smaller than the numbers that were affected after consuming SEA or SEB. This result suggests that these new SEs may play some role in staphylococcal food poisoning.
authors.affiliation: Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Omoe
authors.forename: Dong-Liang
authors.initials: DL
authors.lastname: Hu
authors.forename: Hisaya K
authors.initials: HK
authors.lastname: Ono
authors.forename: Satoru
authors.initials: S
authors.lastname: Shimizu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Takahashi-Omoe
authors.forename: Akio
authors.initials: A
authors.lastname: Nakane
authors.forename: Takehiko
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Shinagawa
authors.forename: Ken'ichi
authors.initials: K
authors.lastname: Imanishi
mesh_terms: D000818:Animals; D004639:Emetics / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D004768:Enterotoxins / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D008252:Macaca fascicularis; D013211:Staphylococcus aureus / Q000235:genetics / Q000378:metabolism*; D014839:Vomiting / Q000139:chemically induced*
chemical_list: D004639:Emetics; D004768:Enterotoxins