title: Regulation of circadian clocks by redox homeostasis.
abstract: Living organisms possess biological clocks that resonate with environmental cycles in light, temperature, and food availability. Recently, circadian oscillations in the redox state of peroxiredoxin have been described as an additional non-transcriptional timekeeping mechanism. Of note, this redox cycle is conserved in both prokaryotes and eukaryotes. How the classical "transcription-translation feedback loop" model and this redox oscillation are related is still poorly understood. In this minireview, we describe the most recent evidence pointing to cross-talk between the circadian clock and the redox status of the cell.
authors.affiliation: From the Department of Clinical Neurosciences, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, National Institute for Health Research (NIHR), Cambridge Biomedical Research Centre, Addenbrooke's Hospital, University of Cambridge, CB2 0QQ Cambridge, United Kingdom.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Stangherlin
authors.forename: Akhilesh B
authors.initials: AB
authors.lastname: Reddy
mesh_terms: D000818:Animals; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm; D015971:Gene Expression Regulation, Enzymologic; D006706:Homeostasis; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D009991:Oscillometry; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D054464:Peroxiredoxins / Q000737:chemistry; D015398:Signal Transduction; D013880:Thioredoxin-Disulfide Reductase / Q000737:chemistry*; D013879:Thioredoxins / Q000737:chemistry
chemical_list: D013879:Thioredoxins; D006861:Hydrogen Peroxide; D054464:Peroxiredoxins; D013880:Thioredoxin-Disulfide Reductase; D010100:Oxygen
keywords: Circadian; Circadian Clock; Circadian Rhythms; Hydrogen Peroxide; Peroxiredoxin; Redox; Redox Regulation; Redox Signaling; Thioredoxin; Thioredoxin Reductase