title: Factors influencing decision making on therapeutic interventions.
abstract: OBJECTIVE
  The aim of this study was to explore factors that influenced decision making in the assessment of new health technology in Korea.
  
  
  METHODS
  We analyzed the decision-making results of the Committee for New Health Technology Assessment (CnHTA) on fifty-three new nondrug health technologies in Korea from July 2007 to December 2010. The scope of the committee was mainly limited to safety and efficacy/effectiveness, and every decision was based on a systematic review of the literature. The committee was composed of healthcare professionals, policy makers, lawyers, and representatives from nongovernmental organizations. Decisions made on therapeutic interventions were included, while those on diagnostic procedures were excluded.
  
  
  RESULTS
  Factors that positively influenced decisions were lower complication rate than existing technology, similar or greater effectiveness compared with existing technology, ability to save critical organs, absence of alternative intervention, decreased invasiveness, expansion of patient's set of choices, and similarity to the mechanism of existing technology. Factors that negatively influenced decisions were higher complication rates than existing technology, lower effectiveness than comparable technology, low levels of evidence, unknown mechanisms of intervention, inconsistency, lack of long-term outcomes, lack of comparative data, nonstandardized technology, heterogeneity between control and treatment, excessively diverse indications, and nongeneralizability.
  
  
  CONCLUSIONS
  This qualitative analysis of past decision-making results provided us with clues on the values that decision makers on the Korean CnHTA considered in terms of safety and effectiveness. These findings will help us develop appraisal guidelines and enhance the objectivity of decision-making processes in Korea.
authors.affiliation: National Evidence-based Healthcare Collaboration Agency, Seoul, Republic of Korea.
authors.forename: Sang Moo
authors.initials: SM
authors.lastname: Lee
authors.forename: Gaeun
authors.initials: G
authors.lastname: Kim
authors.forename: Jeonghoon
authors.initials: J
authors.lastname: Ahn
authors.forename: Hae Sun
authors.initials: HS
authors.lastname: Suh
authors.forename: Dae Seog
authors.initials: DS
authors.lastname: Heo
mesh_terms: D026683:Advisory Committees; D003657:Decision Making; D019317:Evidence-Based Medicine; D006801:Humans; D061214:Patient Safety; D056910:Republic of Korea; D013673:Technology Assessment, Biomedical; D016896:Treatment Outcome