title: Water soluble fluorescence quantum dot probe labeling liver cancer cells.
abstract: Water soluble quantum dots (QDs) have been prepared by hydrothermal method and characterized by ultraviolet irradiation, XRD, TEM, UV-Vis absorption spectrometer and fluorescence spectrometer. Then the QD-antibody-AFP probes (QD-Ab-AFP) were synthesized by chemical process and specifically labeled AFP antigen in PLC/PRF/5 liver cancer cells. The results showed that the QDs were cubic structure and had excellent optical properties. Moreover, the QD-Ab-AFP with good stability could specifically label liver cancer cells. This work provides strong foundation for further studying and developing new approach to detect liver cancer at early stage.
authors.affiliation: Basic Medical College, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Baoxing
authors.initials: B
authors.lastname: Chang
authors.forename: Xianjun
authors.initials: X
authors.lastname: Yang
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Yinsong
authors.initials: Y
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Yang
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Baiqi
authors.initials: B
authors.lastname: Wang
mesh_terms: D045744:Cell Line, Tumor; D005453:Fluorescence; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D046529:Microscopy, Electron, Transmission; D015335:Molecular Probes; D045663:Quantum Dots; D014961:X-Ray Diffraction
chemical_list: D015335:Molecular Probes