title: International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer.
abstract: BACKGROUND
  Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC's core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.
  
  
  METHODS
  Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test-retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA).
  
  
  RESULTS
  Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test-retest and RCA analyses were equivocal.
  
  
  CONCLUSIONS
  The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged 70 years. Changes in elderly patients' self-reported HRQOL may be related to both cancer evolution and non-clinical events.
authors.affiliation: Cancer Sciences, University of Southampton, Southampton SO16 6YD, UK. s.j.wheelwright@soton.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Wheelwright
authors.forename: A-S
authors.initials: AS
authors.lastname: Darlington
authors.forename: D
authors.initials: D
authors.lastname: Fitzsimmons
authors.forename: P
authors.initials: P
authors.lastname: Fayers
authors.forename: J I
authors.initials: JI
authors.lastname: Arraras
authors.forename: F
authors.initials: F
authors.lastname: Bonnetain
authors.forename: E
authors.initials: E
authors.lastname: Brain
authors.forename: A
authors.initials: A
authors.lastname: Bredart
authors.forename: W-C
authors.initials: WC
authors.lastname: Chie
authors.forename: J
authors.initials: J
authors.lastname: Giesinger
authors.forename: E
authors.initials: E
authors.lastname: Hammerlid
authors.forename: S J
authors.initials: SJ
authors.lastname: O'Connor
authors.forename: S
authors.initials: S
authors.lastname: Oerlemans
authors.forename: A
authors.initials: A
authors.lastname: Pallis
authors.forename: M
authors.initials: M
authors.lastname: Reed
authors.forename: N
authors.initials: N
authors.lastname: Singhal
authors.forename: V
authors.initials: V
authors.lastname: Vassiliou
authors.forename: T
authors.initials: T
authors.lastname: Young
authors.forename: C
authors.initials: C
authors.lastname: Johnson
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D015577:Geriatric Assessment; D006304:Health Status; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000503:physiopathology / Q000523:psychology*; D011446:Prospective Studies; D011594:Psychometrics / Q000295:instrumentation; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires