title: Quantum dot lipid oligonucleotide bioconjugates: toward a new anti-microRNA nanoplatform.
abstract: The construction of new nanotools is presented here using the example of fluorescent semiconductor nanocrystals, quantum dots (QDs). In this study, the implementation of the new lipid oligonucleotide conjugate-functionalized quantum dots (LON-QDs) is realized in four steps: (i) the synthesis of the lipid oligonucleotide conjugates (LONs), (ii) the encapsulation of QDs by nucleolipids and LONs, (iii) the study of the duplex formation of LON-QDs with the complementary ON partners, and (iv) the cellular uptake of the LON-QD platform and hybridization with the target ONs (microRNA and miR-21).
authors.forename: Ahissan
authors.initials: A
authors.lastname: Aimé
authors.forename: Nataliia
authors.initials: N
authors.lastname: Beztsinna
authors.forename: Amit
authors.initials: A
authors.lastname: Patwa
authors.forename: Alexander
authors.initials: A
authors.lastname: Pokolenko
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bestel
authors.forename: Philippe
authors.initials: P
authors.lastname: Barthélémy
mesh_terms: D001483:Base Sequence; D001692:Biological Transport; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D042541:Intracellular Space / Q000378:metabolism; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*; D035683:MicroRNAs / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D045663:Quantum Dots / Q000737:chemistry*; D012666:Semiconductors; D012995:Solubility
chemical_list: D008055:Lipids; D035683:MicroRNAs; D009841:Oligonucleotides