title: Comparison of three officinal Chinese pharmacopoeia species of Glycyrrhiza based on separation and quantification of triterpene saponins and chemometrics analysis.
abstract: The dried roots and rhizomes of Glycyrrhiza species, named licorice, have been utilized as food as well as crude drugs in China for thousands of years. Glycyrrhiza species can be differentiated based on the morphologic features of their aerial part, i.e. leaf and fruit morphologies, but not on their root morphology, even though that is the medicinal part. In this paper, a fast and effective UPLC-TQ-MS/MS method was explored for better identification and quantitative investigation of triterpene saponins in licorice, which laid basis for chemical comparison of three officinal Chinese pharmacopoeia Glycyrrhiza species. The results showed that all of these licorice samples were rich in triterpene saponins but with significant difference corresponding to different Glycyrrhiza species. The proposed method could be useful in quality control and standardization of licorice raw materials and its products.
authors.affiliation: Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Tao
authors.forename: Jinao
authors.initials: J
authors.lastname: Duan
authors.forename: Runhuai
authors.initials: R
authors.lastname: Zhao
authors.forename: Xueyu
authors.initials: X
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.forename: Jianping
authors.initials: J
authors.lastname: Li
authors.forename: Sheng
authors.initials: S
authors.lastname: Guo
authors.forename: Nianyun
authors.initials: N
authors.lastname: Yang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Tang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000302:isolation & purification; D006035:Glycyrrhiza / Q000737:chemistry* / Q000145:classification; D012503:Saponins / Q000032:analysis* / Q000302:isolation & purification; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014315:Triterpenes / Q000032:analysis* / Q000302:isolation & purification
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes
keywords: Glycyrrhiza glabra; Glycyrrhiza inflata; Glycyrrhiza uralensis; Licorice; Triterpene saponins; UPLC–TQ-MS/MS