title: Results of treatment for pT1/pT2 carcinomas of the floor of mouth.
abstract: CONCLUSIONS
  In pT2 floor of mouth cancer (FOMC), a standardized neck dissection (ND) should be carried out, due to the high risk of occult metastases. In cases of pT1 carcinomas with a clinically negative neck using high imaging standards and expertise a tight 'wait and watch' strategy can be used.
  
  
  OBJECTIVE
  To report on the oncologic results with primary surgical treatment of pT1/pT2 FOMC and to examine the benefit of elective ND in cN0.
  
  
  METHODS
  This was a retrospective study design including 216 patients who were treated between 1980 and 2010 for pT1/2 FOMC. The 5-year disease-specific survival (DSS), local and (loco)regional control based on the T and N classification and depth of infiltration were investigated.
  
  
  RESULTS
  DSS was 79.5% and (loco)regional control was 89.8%. DSS in patients staged pN0 was significantly higher, at 84.6%, than in those staged pN+, at 60%. ND was performed in 165 patients, and adjuvant therapy was administered in 124 patients. Ninety patients (41.7%) were staged cN0, and 53.3% of them underwent elective ND. The risk of occult metastases was 4.8% in pT1 and 28.6% in pT2. A depth of infiltration of ≥ 5 mm showed a markedly higher relative frequency of occult neck metastases and pN+ status.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen-Nuremberg Medical School, Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Künzel
authors.forename: Georgios
authors.initials: G
authors.lastname: Psychogios
authors.forename: Michael
authors.initials: M
authors.lastname: Koch
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Mantsopoulos
authors.forename: Markus
authors.initials: M
authors.lastname: Kapsreiter
authors.forename: Heinrich
authors.initials: H
authors.lastname: Iro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology / Q000628:therapy*; D037981:Neck Dissection / Q000379:methods; D012189:Retrospective Studies