title: Combined C-H functionalization/O-H insertion reaction to form tertiary β-alkoxy substituted β-aminophosphonates catalyzed by [Cu(MeCN)4]PF6.
abstract: The copper-catalyzed C-H functionalization/O-H insertion reaction of α-diazophosphonates with alcohols has been developed with iodine as an additive. In order to understand this reaction, we present here a possible mechanism for the combined reaction. This process provides straightforward access to tertiary β-alkoxy substituted β-aminophosphonate derivatives with moderate to good yields.
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cai
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Lu
authors.forename: Chengbin
authors.initials: C
authors.lastname: Yu
authors.forename: Hairong
authors.initials: H
authors.lastname: Lyu
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Miao
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000615:Aminoethylphosphonic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000438:Alcohols; D001391:Azo Compounds; D009942:Organometallic Compounds; D063065:Organophosphonates; C059688:alkoxyl radical; D003300:Copper; D007455:Iodine; D000615:Aminoethylphosphonic Acid