title: Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family.
abstract: The giant cytoskeletal kinases of the titin-like family are emerging as key mediators of stretch-sensing in muscle. It is thought that their elastic conformational deformation during muscle function regulates both their catalysis and the recruitment of regulatory proteins to signalosomes that assemble in their vicinity. In the present article, we discuss the speciation of mechanosensory mechanisms in titin-like kinases, their scaffolding properties and the kinase/pseudokinase domain variations that define a rich functional diversity across the family.
authors.affiliation: Institute of Integrative Biology, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK. Olga.Mayans@liv.ac.uk
authors.forename: Olga
authors.initials: O
authors.lastname: Mayans
authors.forename: Guy M
authors.initials: GM
authors.lastname: Benian
authors.forename: Felix
authors.initials: F
authors.lastname: Simkovic
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rigden
mesh_terms: D064211:Connectin / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D009124:Muscle Proteins / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*
chemical_list: D064211:Connectin; D009124:Muscle Proteins; D011494:Protein Kinases