title: PPARγ and PPARGC1B polymorphisms modify the association between phthalate metabolites and breast cancer risk.
abstract: BACKGROUND
  Breast cancer (BC) risk has been differentially associated with urinary levels of some phthalate metabolites.
  
  
  OBJECTIVE
  To investigate whether PPARγ and PPARGC1B polymorphisms modulate these associations.
  
  
  METHODS
  208 BC cases were age-matched with 220 population controls. Phthalate metabolites were determined by HPLC-MS. PPARγ Pro12Ala (rs1801281) and PPARGC1B Ala203Pro (rs7732671) and Val279Ile (rs17572019) were genotyped.
  
  
  RESULTS
  The association between mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and BC risk was positively modified in PPARγ Pro12Ala C carriers. The association with mono-iso-butyl phthalate (MiBP) in PPARGC1B Ala203Pro G carriers was negatively modified.
  
  
  CONCLUSIONS
  PPARγ and PPARGC1B polymorphisms modulate the association between phthalate exposure and BC risk.
authors.affiliation: National Institute of Public Health , Cuernavaca, Morelos , Mexico and.
authors.forename: Gabriela A
authors.initials: GA
authors.lastname: Martínez-Nava
authors.forename: Ana I
authors.initials: AI
authors.lastname: Burguete-García
authors.forename: Lizbeth
authors.initials: L
authors.lastname: López-Carrillo
authors.forename: Raúl U
authors.initials: RU
authors.lastname: Hernández-Ramírez
authors.forename: Vicente
authors.initials: V
authors.lastname: Madrid-Marina
authors.forename: Mariano E
authors.initials: ME
authors.lastname: Cebrián
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D047495:PPAR gamma / Q000235:genetics*; D010795:Phthalic Acids / Q000378:metabolism* / Q000652:urine; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins
chemical_list: D002352:Carrier Proteins; D047495:PPAR gamma; C455622:PPARGC1B protein, human; D010795:Phthalic Acids; D016601:RNA-Binding Proteins