title: pocrm: an R-package for phase I trials of combinations of agents.
abstract: This paper presents the R package pocrm for implementing and simulating the partial order continual reassessment method (PO-CRM; [1,2]) in Phase I trials of combinations of agents. The aim of this article is to illustrate, through examples of the pocrm package, how the PO-CRM works and how its operating characteristics can inform clinical trial investigators. This should promote the use of the PO-CRM in designing and conducting dose-finding Phase I trials of combinations of agents.
authors.affiliation: Division of Translational Research and Applied Statistics, Department of Public Health Sciences University of Virginia, Charlottesville, VA 22908, USA. Electronic address: nwages@virginia.edu.
authors.forename: Nolan A
authors.initials: NA
authors.lastname: Wages
authors.forename: Nikole
authors.initials: N
authors.lastname: Varhegyi
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D019496:Cancer Vaccines / Q000008:administration & dosage; D017321:Clinical Trials, Phase I as Topic / Q000706:statistics & numerical data*; D003198:Computer Simulation; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006801:Humans; D008055:Lipids / Q000008:administration & dosage; D020714:Maximum Tolerated Dose; D008545:Melanoma / Q000628:therapy; D009369:Neoplasms / Q000188:drug therapy*; D012984:Software; D051193:Toll-Like Receptors / Q000819:agonists
chemical_list: D000970:Antineoplastic Agents; D019496:Cancer Vaccines; D008055:Lipids; D051193:Toll-Like Receptors; C114843:incomplete Freund's adjuvant; D005620:Freund's Adjuvant
keywords: Continual reassessment method; Dose finding; Drug combination; Partial ordering; Phase I trials