title: [Peculiarities of the lower extremities perfusion in patients with complicated diabetic foot syndrome].
abstract: Analysis of the microcirculation indices in 246 patients, suffering diabetic foot syndrome (DFS), was presented. For a neuropathic form of DFS characteristic is lowering of the arterioles tone and enhancement of the blood volume in them, witnessed by raising of constant component of the blood flow. General worsening of perfusion is caused by lowering of endothelial secretion activation, and as well as neurogenic and myogenic control mechanisms. Occurrence of neurogenic regulation disorder is witnessed by the neurogenic oscillations lowering, the neurogenic and myogenic tone raising. In ischemic form of DFS there was noted the perfusion disorder, connected with reduction of the arterial inflow volume. The indices changes witness the disorder of sympathetic regulation of microcirculation and arteriole-venular reactions. The change of the perfusion indices, caused by a congestion processes in arterioles and venules, is characteristic for the mixed form of DFS. The perfusion control mechanisms was noted, as a consequence of the endothelial secretion lowering and the neurogenic and myogenic mechanisms activation of a control. The neurogenic and myogenic tone raising occurs depending on the sympathetic component activity, causing the arterioles diameter reduction.
authors.forename: S D
authors.initials: SD
authors.lastname: Shapoval
authors.forename: I L
authors.initials: IL
authors.lastname: Savon
authors.forename: D A
authors.initials: DA
authors.lastname: Smirnova
authors.forename: V B
authors.initials: VB
authors.lastname: Martyniuk
authors.forename: L A
authors.initials: LA
authors.lastname: Vasilevskaia
authors.forename: A N
authors.initials: AN
authors.lastname: Iakunich
authors.forename: M M
authors.initials: MM
authors.lastname: Sofilkanych
mesh_terms: D000368:Aged; D001160:Arterioles / Q000473:pathology / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D017719:Diabetic Foot / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D005528:Foot / Q000098:blood supply / Q000294:innervation; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology