title: Reporter gene imaging.
abstract: OBJECTIVE
  The purposes of this article are to summarize the basic concept and the strategies of reporter imaging; introduce reporter genes frequently used in optical imaging, nuclear medicine, and MRI for in vivo application; and show typical examples of reporter gene imaging.
  
  
  CONCLUSIONS
  In molecular biology, many reporter genes have been developed for monitoring cellular processes. Development of controlled gene delivery systems promotes construction of various types of reporter genes for monitoring the level of a gene expression, promoter activity, and protein-protein interaction. When an imaging reporter gene is placed under the control of a promoter, the amount of reporter protein can be dynamically visualized in vivo. Instrumental advances in molecular imaging have increased the sensitivity and resolution of in vivo reporter imaging. Though several types of reporters and multimodal imaging instruments are currently available, more efficient multimodal reporter gene systems and detectors compatible with several imaging modalities are needed.
authors.affiliation: Department of Nuclear Medicine and Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. jkchung@plaza.snu.ac.kr
authors.forename: Hyewon
authors.initials: H
authors.lastname: Youn
authors.forename: June-Key
authors.initials: JK
authors.lastname: Chung
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods; D015870:Gene Expression; D017930:Genes, Reporter; D015316:Genetic Therapy / Q000379:methods; D008279:Magnetic Resonance Imaging; D008495:Medical Oncology / Q000379:methods; D008967:Molecular Biology / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D062346:Molecular Medicine / Q000379:methods; D015336:Molecular Probe Techniques; D055095:Optics and Photonics; D057285:Precision Medicine