title: Serum Level of Interleukin 17 in Patients with Erosive and Non erosive Oral Lichen Planus.
abstract: OBJECTIVE
  Oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. Regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study evaluated the serum interleukin-17 (IL-17) level in patients with erosive and non-erosive oral lichen planus.
  
  
  METHODS
  This descriptive analytical study included 24 patients with erosive oral lichen planus (EOLP), 24 patients with non-erosive oral lichen planus (NEOLP) and 24 healthy volunteered as control. Blood samples of the subjects underwent ELISA, using special kits, to determine serum interleukin-17 levels. Data was analyzed using with descriptive statistic, chi-square test, and one-way ANOVA and Tukey post-hoc test with SPSS 16 software.
  
  
  RESULTS
  EOLP patients showed a high level of serum IL-17 compared with NEOLP patents and control groups (EOLP=184.16 ± 12.41 pg/mL, NEOLP=106.09±10.78 pg/mL, control=15.50 ± 4.34 pg/mL, P - 0.001).
  
  
  CONCLUSIONS
  High level of serum IL-17 in erosive oral lichen planus patients compared to the non-erosive type and healthy individuals may be the reason for higher inflammation and atrophy in the erosive type.
authors.affiliation: Dntal and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Tabriz University, Tabriz, Iran.
authors.forename: Firoz
authors.initials: F
authors.lastname: Pouralibaba
authors.forename: Zohre
authors.initials: Z
authors.lastname: Babaloo
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Pakdel
authors.forename: Marziye
authors.initials: M
authors.lastname: Aghazadeh
keywords: Biopsy; interleukin-17; oral lichen planus