title: The minichromosome maintenance replicative helicase.
abstract: The eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex, is composed of six distinct, but related, subunits MCM(2-7). The relationship between the sequences of the subunits indicates that they are derived from a common ancestor and indeed, present-day archaea possess a homohexameric MCM. Recent progress in the biochemical and structural studies of both eukaryal and archaeal MCM complexes are beginning to shed light on the mechanisms of action of this key component of the replisome.
authors.affiliation: Molecular and Cellular Biochemistry Department, Biology Department, Indiana University, Bloomington, Indiana 47405.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Bell
authors.forename: Michael R
authors.initials: MR
authors.lastname: Botchan
mesh_terms: D000818:Animals; D001105:Archaea / Q000378:metabolism*; D019843:Archaeal Proteins / Q000378:metabolism; D002474:Cell-Free System; D004265:DNA Helicases / Q000378:metabolism*; D004331:Drosophila melanogaster; D017013:Methanobacteriaceae / Q000378:metabolism; D064110:Minichromosome Maintenance Proteins / Q000378:metabolism*; D008958:Models, Molecular; D010957:Plasmids / Q000378:metabolism; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D014981:Xenopus
chemical_list: D019843:Archaeal Proteins; D029701:Saccharomyces cerevisiae Proteins; D004265:DNA Helicases; D064110:Minichromosome Maintenance Proteins