title: Terahertz spectroscopy for the assessment of burn injuries in vivo.
abstract: A diagnosis criterion is proposed for noninvasive grading of burn injuries using terahertz radiation. Experimental results are presented from in vivo terahertz time-domain spectroscopy of second- and third-degree wounds, which are obtained in a 72-hour animal study. During this period, the change in the spectroscopic response of the burned tissue is studied. It is shown that terahertz waves are sensitive not only to the postburn formation of interstitial edema, but also to the density of skin structures derived from image processing analysis of histological sections. Based on these preliminary results, it is suggested that the combination of these two effects, as probed by terahertz spectroscopy of the tissue, may ultimately be used to differentiate partial-thickness burns that will naturally heal from those that will require surgical intervention.
authors.affiliation: University of Washington, Applied Physics Laboratory, 1013 NE 40th Street, Seattle, Washington 98105-6698, USA. mharbab@uw.edu
authors.forename: M Hassan
authors.initials: MH
authors.lastname: Arbab
authors.forename: Dale P
authors.initials: DP
authors.lastname: Winebrenner
authors.forename: Trevor C
authors.initials: TC
authors.lastname: Dickey
authors.forename: Antao
authors.initials: A
authors.lastname: Chen
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Klein
authors.forename: Pierre D
authors.initials: PD
authors.lastname: Mourad
mesh_terms: D000818:Animals; D002056:Burns / Q000175:diagnosis / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000737:chemistry* / Q000473:pathology*; D055068:Terahertz Spectroscopy / Q000379:methods*; D014945:Wound Healing