title: 1,25(OH)₂D₃ and specific IgE levels in children with recurrent tonsillitis, and allergic rhinitis.
abstract: OBJECTIVE
  We investigated 1,25-dihydroxyvitamin D3 [1,25(OH)₂D₃] and specific immunoglobulin E (IgE) levels in children with recurrent tonsillitis (RT) plus allergic rhinitis (AR).
  
  
  METHODS
  Thirty children with RT+AR were included in the study group, and 30 healthy children comprised the control group. AR-related symptoms were determined using a symptom scale. 1,25(OH)₂D₃ and specific IgE measurements were made in both groups.
  
  
  RESULTS
  The 1,25(OH)₂D₃ value was significantly lower in the RT+AR group than in the control group. Specific IgE (mixed) panels were in normal limits in both groups; whereas specific IgE (mixed) grass pollen panel value of RT+AT group was significantly higher than that of the control group. Higher nasal itching, nasal obstruction, and concha edema scores were related to significantly higher specific IgE values for the (mixed) grass pollen panel, whereas higher sneeze scores were related to higher specific IgE values for the (mixed) pediatric panel.
  
  
  CONCLUSIONS
  Children with grass pollen allergy may not be exposed to sufficient sunlight. With reduced 1,25(OH)₂D₃, T helper cells may increase, and allergic response also increases. As allergic events increased, these children did not go outside and thus lacked sun exposure. This vicious cycle must be broken, and children with RT+AR should have sunlight exposure to increase 1,25(OH)₂D₃ levels.
authors.affiliation: Istanbul Medeniyet University, Göztepe Training and Research Hospital, ENT Department , Istanbul, Turkey.
authors.forename: Turhan
authors.initials: T
authors.lastname: San
authors.forename: Nuray Bayar
authors.initials: NB
authors.lastname: Muluk
authors.forename: Cemal
authors.initials: C
authors.lastname: Cingi
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000097:blood*; D008297:Male; D011058:Pollen / Q000276:immunology; D011863:Radioimmunoassay; D012008:Recurrence; D012016:Reference Values; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000175:diagnosis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014069:Tonsillitis / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D007073:Immunoglobulin E; D015650:24,25-Dihydroxyvitamin D 3
keywords: 1,25(OH)(2)D(3) level; Children; Specific IgE (mixed) grass pollen panel