title: Hepatitis C virus infection is not an independent risk factor for obstructive lung disease.
abstract: Several epidemiological studies have suggested that hepatitis C virus (HCV) infection is associated with the presence of obstructive lung disease (OLD). However, there is a strong link between HCV infection and tobacco abuse, a major risk factor for the development of OLD. In this study we analyzed clinical, laboratory and spirometric data from 1068 study participants to assess whether HCV infection, viremia, or HCV-associated end organ damage were associated with OLD. Demographics, risk behavior, serologic status for HCV and HIV, and spirometric measurements were collected from a cross-sectional analysis of the Acquired Immunodeficiency Syndrome (AIDS) Linked to the IntraVenous Experience (ALIVE) study, an observational cohort of IDUs followed in Baltimore, MD since 1988. Of 1,068 participants, 890 (83%) were HCV positive and 174 (16%) met spirometric criteria for OLD. Factors independently associated with OLD were age and BMI. HCV infection, viral load and HCV-associated end organ damage were similar in participants with and without OLD. In summary, there was no independent association between markers of HCV exposure, chronicity, viremia, or HCV-associated end-organ damage with OLD. Our findings support the strong correlation between HCV status, injection drug use, and smoking. These data suggest that HCV may not be a sole contributor to the increased prevalence of OLD described in previous studies of HCV-infected individuals.
authors.affiliation: 1Division of Pulmonary and Critical Care, The Johns Hopkins University School of Medicine , Baltimore, Maryland , USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Fischer
authors.forename: Michael B
authors.initials: MB
authors.lastname: Drummond
authors.forename: Christian A
authors.initials: CA
authors.lastname: Merlo
authors.forename: David L
authors.initials: DL
authors.lastname: Thomas
authors.forename: Robert
authors.initials: R
authors.lastname: Brown
authors.forename: Shruti H
authors.initials: SH
authors.lastname: Mehta
authors.forename: Robert A
authors.initials: RA
authors.lastname: Wise
authors.forename: Greg D
authors.initials: GD
authors.lastname: Kirk
mesh_terms: D000328:Adult; D000367:Age Factors; D015142:Baltimore / Q000453:epidemiology; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D019698:Hepatitis C, Chronic / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008173:Lung Diseases, Obstructive / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*; D013147:Spirometry; D015819:Substance Abuse, Intravenous / Q000453:epidemiology*; D019562:Viral Load; D014766:Viremia / Q000453:epidemiology