title: Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus.
abstract: We hypothesized that ubiquitin-conjugating enzyme E2 E2 (UBE2E2) may be associated with gestational diabetes mellitus (GDM) and conducted association analyses. A total of 2071 subjects were recruited for the study, with 1104 cases and 967 controls. Two UBE2E2 single-nucleotide polymorphisms rs6780569 and rs7612463, and their haplotypes were analyzed for the study. As a result, rs7612463 showed a significant association with GDM in the recessive model. In addition, the regression analyses for the phenotypes showed that rs6780569. rs7612463 and ht2 showed significant associations with fasting plasma glucose (FPG) in recessive models, while ht1 showed an association in the dominant model. Our results show that the genetic variants of UBE2E2 are associated with GDM and FPG, which could be an important preliminary result for future studies.
authors.affiliation: Department of Life Science, Sogang University , Mapo-gu, Seoul, Republic of Korea.
authors.forename: Jason Y
authors.initials: JY
authors.lastname: Kim
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Byung-Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Sei Hyun
authors.initials: SH
authors.lastname: Baik
authors.forename: Sunmin
authors.initials: S
authors.lastname: Park
authors.forename: Seogho
authors.initials: S
authors.lastname: Kim
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000453:epidemiology / Q000235:genetics*; D005215:Fasting / Q000097:blood; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012306:Risk; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; C106347:UBE2E2 protein, human; D044763:Ubiquitin-Conjugating Enzymes