title: Concentration of hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of Yusho patients in 2010.
abstract: Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We measured the concentration of OH-PCBs in blood collected from 183 Yusho patients living in Japan in 2010. The major OH-PCB metabolites were 4-OH-CB187 (ND-1300 pg/g-wet), 4-OH-CB146 + 3-OH-CB153 (8.4-1200 pg/g-wet), 4-OH-CB109 (ND-530 pg/g-wet) and 4'-OH-CB172 (ND-380 pg/g-wet). The total OH-PCBs ranged from 36 to 3800 pg/g-wet. A positive relationship between the concentrations of OH-PCBs and PCBs was observed, but no significant relationship between the concentrations of OH-PCBs and PCDD/DFs was observed.
authors.affiliation: Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka 818-0135, Japan. tobiishi@fihes.pref.fukuoka.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tobiishi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Todaka
authors.forename: Hironori
authors.initials: H
authors.lastname: Hirakawa
authors.forename: Tsuguhide
authors.initials: T
authors.lastname: Hori
authors.forename: Jumboku
authors.initials: J
authors.lastname: Kajiwara
authors.forename: Teruaki
authors.initials: T
authors.lastname: Hirata
authors.forename: Takao
authors.initials: T
authors.lastname: Iida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchi
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
mesh_terms: D006801:Humans; D006900:Hydroxylation; D007564:Japan; D011078:Polychlorinated Biphenyls / Q000097:blood*; D011164:Porphyrias / Q000097:blood*
chemical_list: D011078:Polychlorinated Biphenyls