title: The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.
abstract: Vascular adhesion protein-1 (VAP-1) has been implicated in the pathogenesis of inflammatory diseases and is suggested to play a role in immune cell trafficking. It is not clear whether this effect is mediated by the oxidase activity or by other features of the protein such as direct adhesion. In order to study the role of VAP-1 oxidase activity in vivo, we have generated mice carrying an oxidase activity-null VAP-1 protein. We demonstrate that the VAP-1 oxidase null mutant mice have a phenotype similar to the VAP-1 null mice in animal models of sterile peritonitis and antibody induced arthritis suggesting that the oxidase activity is responsible for the inflammatory function of VAP-1.
authors.affiliation: Boehringer Ingelheim Pharmaceuticals 900 Ridgebury Road, Ridgefield, CT 06877.
authors.forename: Thomas
authors.initials: T
authors.lastname: Noonan
authors.forename: Susan
authors.initials: S
authors.lastname: Lukas
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Peet
authors.forename: Josephine
authors.initials: J
authors.lastname: Pelletier
authors.forename: Mark
authors.initials: M
authors.lastname: Panzenbeck
authors.forename: Adedayo
authors.initials: A
authors.lastname: Hanidu
authors.forename: Suzanne
authors.initials: S
authors.lastname: Mazurek
authors.forename: Ruby
authors.initials: R
authors.lastname: Wasti
authors.forename: Irina
authors.initials: I
authors.lastname: Rybina
authors.forename: Teresa
authors.initials: T
authors.lastname: Roma
authors.forename: Anthony
authors.initials: A
authors.lastname: Kronkaitis
authors.forename: Alycia
authors.initials: A
authors.lastname: Shoultz
authors.forename: Donald
authors.initials: D
authors.lastname: Souza
authors.forename: Huiping
authors.initials: H
authors.lastname: Jiang
authors.forename: Gerald
authors.initials: G
authors.lastname: Nabozny
authors.forename: Louise Kelly
authors.initials: LK
authors.lastname: Modis
keywords: Vascular adhesion protein-1 (VAP-1); immune cell trafficking; inflammatory function; oxidase activity; semicarbazide-sensitive amine oxidase