title: [The serum level transformation of IFN-gamma, IL-4 and IgE before and after SIT in patients with allergic rhinitis].
abstract: OBJECTIVE
  To assess the efficacy and the transformation of IFN-gamma, IL-4, total IgE and specific IgE before and after specific immune therapy(SIT) in patients with allergic rhinitis.
  
  
  METHODS
  The subjective symptom and levels of IFN-gamma, IL-4, total IgE and specific IgE were observed in 40 patients with allergic rhinitis before and after SIT.
  
  
  RESULTS
  Total effective rate in patients after SIT was 85%. There's no significant difference between the levels of specific IgE before and after SIT(P>0.05) ,while the levels of IL-4 and total IgE were significantly lower, the levels of IFN-gamma were significantly higher pre than that of post SIT.
  
  
  CONCLUSIONS
  SIT is safe and effective,and can regulate the levels of IFN-gamma, IgE and IL-4. But the role of specific IgE in SIT is still unknown.
authors.affiliation: Department of Otorhinolaryngology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, 223300, China.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Li
authors.forename: Peizhong
authors.initials: P
authors.lastname: Li
mesh_terms: D000328:Adult; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007371:Interferon-gamma / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000276:immunology / Q000628:therapy; D044967:Serum / Q000378:metabolism; D055815:Young Adult
chemical_list: C508598:IL4 protein, human; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma