title: Assessment of respiration-induced motion and its impact on treatment outcome for lung cancer.
abstract: This study presented the analysis of free-breathing lung tumor motion characteristics using GE 4DCT and Varian RPM systems. Tumor respiratory movement was found to be associated with GTV size, the superior-inferior tumor location in the lung, and the attachment degree to rigid structure (e.g., chest wall, vertebrae, or mediastinum), with tumor location being the most important factor among the other two. Improved outcomes in survival and local control of 43 lung cancer patients were also reported. Consideration of respiration-induced motion based on 4DCT for lung cancer yields individualized margin and more accurate and safe target coverage and thus can potentially improve treatment outcome.
authors.affiliation: Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Bao
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Fan
authors.forename: Han
authors.initials: H
authors.lastname: He
authors.forename: Zong-Wen
authors.initials: ZW
authors.lastname: Sun
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.forename: Shao-Min
authors.initials: SM
authors.lastname: Huang
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: Xiao-Wu
authors.initials: XW
authors.lastname: Deng
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009068:Movement; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D012119:Respiration; D055752:Small Cell Lung Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D016896:Treatment Outcome