title: Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb.
abstract: Two new steroidal saponins, named drangustosides A-B (1-2), together with eight known compounds were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.
authors.affiliation: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.
authors.forename: Hui-Chi
authors.initials: HC
authors.lastname: Huang
authors.forename: Ming-Kuem
authors.initials: MK
authors.lastname: Lin
authors.forename: Syh-Yuan
authors.initials: SY
authors.lastname: Hwang
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Chi-I
authors.initials: CI
authors.lastname: Chang
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Ou
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D031409:Dracaena / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology; D013481:Superoxides / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012503:Saponins; D013256:Steroids; D013481:Superoxides; D010196:Pancreatic Elastase