title: Desymmetrization of bicyclo[3.n.1]-3-one derivatives by palladium-catalyzed asymmetric allylic alkylation.
abstract: Desymmetrization of carbon nucleophiles by palladium-catalyzed asymmetric allylic alkylation has been realized for the first time. Products with three chiral centers were obtained in good yield and with high diastereo- and enantioselectivity. The method offers an efficient access to optically active tropane derivatives.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Yang
authors.forename: Chao-Fan
authors.initials: CF
authors.lastname: Xu
authors.forename: Chang-Hua
authors.initials: CH
authors.lastname: Ding
authors.forename: Xue-Long
authors.initials: XL
authors.lastname: Hou
mesh_terms: D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium; D013237:Stereoisomerism; D014326:Tropanes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000498:Allyl Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D014326:Tropanes; D010165:Palladium