title: [Association of HLA-DM gene with childhood systemic lupus erythematosus].
abstract: OBJECTIVE
  To explore the association of HLA-DM gene with childhood systemic lupus erythematosus (SLE).
  
  
  METHODS
  DMA and DMB genes were genotyped by sequence-based typing(SBT)in 79 SLE patients at our hospital from 2003 to 2006 and 57 normal controls.
  
  
  RESULTS
  The frequency of DMB*0101/0102 was lower significantly in SLE patients than that in controls (5.1% vs 21.1%). And the frequency of DMB*0102/0102 in SLE patients with renal involvement was higher than that in controls (17.6% vs 1.8%, P < 0.05). The frequency of all alleles and other genotypes had no significance in SLE patients, SLE patients with different organ involvements and controls.
  
  
  CONCLUSIONS
  As a protective gene, DMB*0102/0102 may be a susceptible allele for SLE patients with renal involvement.
authors.affiliation: Department of Rheumatology & Immunology, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
authors.forename: Jun-mei
authors.initials: JM
authors.lastname: Zhang
authors.forename: Cai-feng
authors.initials: CF
authors.lastname: Li
authors.forename: Xiao-hu
authors.initials: XH
authors.lastname: He
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male
chemical_list: D006681:HLA-D Antigens; C084245:HLA-DM antigens