title: Arsenic trioxide induced endoplasmic reticulum stress in laryngeal squamous cell line Hep-2 cells.
abstract: Arsenic trioxide (As2O3) has been used in the treatment of acute promyelocytic leukemia (APL) and many malignant solid tumors. Recently, endoplasmic reticulum (ER) stress plays an important role in As2O3-treated laryngeal squamous cell line Hep-2 cells. In the present work, the expression of ER stress-related proteins was investigated in As2O3-treated Hep-2 cells. The results showed that As2O3 increased the expression of GRP78, CHOP, phosphorylated eIF2α and ATF4, all of which are the molecule of ER stress. Therefore, As2O3 induced ER stress in Hep-2 cells.
authors.affiliation: Jining Medical University, Jining, Shandong Province, PR China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Rizhao People's Hospital, Rizhao, Shandong Province, PR China.
authors.forename: Liangxiang
authors.initials: L
authors.lastname: An
authors.affiliation: The Affiliated Hospital of Jining Medical University, Jining, Shandong Province, PR China. Electronic address: lixiaoyu6666@aliyun.com.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
mesh_terms: D051701:Activating Transcription Factor 4 / Q000187:drug effects* / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D045744:Cell Line, Tumor; D000091342:Endoplasmic Reticulum Chaperone BiP; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects* / Q000502:physiology; D015852:Eukaryotic Initiation Factor-2 / Q000187:drug effects* / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism; D010087:Oxides / Q000494:pharmacology*; D000077195:Squamous Cell Carcinoma of Head and Neck; D051742:Transcription Factor CHOP / Q000187:drug effects*
chemical_list: C497109:ATF4 protein, human; D000970:Antineoplastic Agents; D001152:Arsenicals; C497249:DDIT3 protein, human; D000091342:Endoplasmic Reticulum Chaperone BiP; D015852:Eukaryotic Initiation Factor-2; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins; D010087:Oxides; D051701:Activating Transcription Factor 4; D051742:Transcription Factor CHOP; D000077237:Arsenic Trioxide
keywords: Arsenic trioxide; CHOP; Endoplasmic reticulum stress; GRP78; Hep-2