title: A systematic review of the effects of NMDA receptor antagonists on oscillatory activity recorded in vivo.
abstract: Distinct frequency bands can be differentiated from neuronal ensemble recordings, such as local field potentials or electrocorticogram recordings. Recent years have witnessed a rapid acceleration of research examining how N-methyl-D-aspartate receptor (NMDAR) antagonists influence fundamental frequency bands in cortical and subcortical brain regions. Herein, we systematically review findings from in vivo studies with a focus on delta, theta, gamma and more recently identified high-frequency oscillations. We also discuss some of the current hypotheses that are considered to account for the actions of NMDAR antagonists on these frequency bands. The data emphasize a close relationship between altered oscillatory activity and NMDAR blockade, with both local and large-scale networks accounting for their effects. These findings may have fundamental implications for the psychotomimetic effects produced by NMDAR antagonists.
authors.affiliation: Laboratory of the Limbic System, Nencki Institute of Experimental Biology, Warsaw, Poland.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Hunt
authors.forename: Stefan
authors.initials: S
authors.lastname: Kasicki
mesh_terms: D000818:Animals; D058256:Brain Waves / Q000187:drug effects* / Q000502:physiology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Animal study; NMDA receptor antagonists; brain; frequency bands; oscillations; rat studies; review