title: The value of clinical electrophysiology in the assessment of the eye and visual system in the era of advanced imaging.
abstract: Electrophysiological techniques allow clinical investigations to include a 'dissection' of the visual system. Using suitable electrophysiological techniques, the 'dissection' allows function to be ascribed to the different photoreceptors (rod and cone photoreceptors), retinal layers, retinal location or the visual pathway up to the visual cortex. Combined with advances in genetics, retinal biochemistry, visual fields and ocular imaging, it is now possible to obtain a better understanding of diseases affecting the retina and visual pathways. This paper reviews core electrophysiological principles that can complement other examination techniques, including advanced ocular imaging, and help the interpretation of other clinical data and thus, refine and guide clinical diagnosis.
authors.affiliation: Centre for Eye Health, University of New South Wales, Kensington, New South Wales, Australia; School of Optometry and Vision Science, University of New South Wales, Kensington, New South Wales, Australia.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Whatham
authors.forename: Vincent
authors.initials: V
authors.lastname: Nguyen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Michael
authors.initials: M
authors.lastname: Hennessy
authors.forename: Michael
authors.initials: M
authors.lastname: Kalloniatis
mesh_terms: D003117:Color Vision Defects / Q000503:physiopathology; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D009902:Optic Neuritis / Q000503:physiopathology; D012164:Retinal Diseases / Q000503:physiopathology; D012174:Retinitis Pigmentosa / Q000503:physiopathology; D014785:Vision, Ocular; D014795:Visual Pathways / Q000502:physiology*
keywords: cone dystrophy; congenital stationary night blindness; electro-oculography; electroretinography; fundus albipunctatus; optic neuritis; retinal detachment; retinitis pigmentosa; rod monochromacy; rod-cone dystrophy; visual evoked potential