title: Effects of ampicillin/sulbactam and enrofloxacin on the blood pressure of isoflurane anesthetized dogs.
abstract: A blinded, prospective, randomized crossover study was performed to determine the effects of ampicillin Na/sulbactam Na and enrofloxacin on the blood pressure (BP) of healthy anesthetized dogs. Eight dogs were anesthetized three different times. They randomly received enrofloxacin, ampicillin Na/sulbactam Na, and saline. Systolic, diastolic, and mean arterial BPs (SAP, DAP, and MAP, respectively), heart rate (HR), O2 saturation of hemoglobin, end-tidal CO2 (ETCO2) concentration, inspired isoflurane concentration, end-tidal isoflurane (ETiso) concentration, respiratory rate, electrocardiogram, and body temperature were measured for 20 min prior to administration of treatment, during administration over 30 min, and for 30 min after administration. There was no significant difference in the SAP or ETiso. There was no significant change in the arterial pressure values over time in the enrofloxacin and ampicillin Na/sulbactam Na groups. The control group's MAP increased over time and was increased compared with the enrofloxacin group at times 25, 35, 45, and 55. The statistical difference between the enrofloxacin and the control groups was due to an increase in the MAP in the control group, not a decrease in the enrofloxacin group's BP. Neither enrofloxacin nor ampicillin Na/sulbactam Na caused hypotension in healthy dogs anesthetized with isoflurane and fentanyl.
authors.affiliation: Department of Small Animal Surgery, Small Animal Clinical Sciences, Oklahoma State University, Stillwater, OK, USA. jmoorer@okstate.edu
authors.forename: Jeremiah D
authors.initials: JD
authors.lastname: Moorer
authors.forename: Heather A
authors.initials: HA
authors.lastname: Towle-Millard
authors.forename: Marjorie E
authors.initials: ME
authors.lastname: Gross
authors.forename: Mark E
authors.initials: ME
authors.lastname: Payton
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019072:Antibiotic Prophylaxis / Q000592:standards; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D018592:Cross-Over Studies; D004285:Dogs; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000494:pharmacology*; D013407:Sulbactam / Q000494:pharmacology; D013530:Surgical Wound Infection / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin; C035444:sultamicillin; D000667:Ampicillin; D007530:Isoflurane; D013407:Sulbactam