title: Word of caution before implementing ketotifen for gastrointestinal transit improvement.
abstract: The therapeutic potential of long-term ketotifen in irritable bowel syndrome and postoperative ileus is currently under investigation. Ambiguous results of prolonged postoperative ketotifen use on gastrointestinal passage have been found. The current data point at a hampered gastrointestinal transit after prolonged postoperative ketotifen use in a rodent ileus induction model. Therefore, caution should be taken when administering ketotifen in the perioperative phase.
authors.forename: Kostan W
authors.initials: KW
authors.lastname: Reisinger
authors.forename: Jacco J
authors.initials: JJ
authors.lastname: de Haan
authors.forename: Marc H
authors.initials: MH
authors.lastname: Schreinemacher
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects; D005772:Gastrointestinal Transit / Q000187:drug effects*; D045823:Ileus / Q000188:drug therapy*; D043183:Irritable Bowel Syndrome / Q000188:drug therapy; D007665:Ketotifen / Q000009:adverse effects* / Q000627:therapeutic use*; D008297:Male; D059035:Perioperative Period; D011183:Postoperative Complications; D051381:Rats; D017208:Rats, Wistar; D012235:Rhodamines / Q000494:pharmacology; D013997:Time Factors
chemical_list: D012235:Rhodamines; D007665:Ketotifen
keywords: Gastrointestinal transit; Ketotifen; Postoperative ileus