title: Extending the cellulosome paradigm: the modular Clostridium thermocellum cellulosomal serpin PinA is a broad-spectrum inhibitor of subtilisin-like proteases.
abstract: Clostridium thermocellum encodes a cellulosomal, modular, and thermostable serine protease inhibitor (serpin), PinA. PinA stability but not inhibitory activity is affected by the Fn(III) and Doc(I) domains, and PinA is a broad inhibitor of subtilisin-like proteases and may play a key role in protecting the cellulosome from protease attack.
authors.affiliation: CSIRO Animal, Food and Health Sciences, Queensland Biosciences Precinct, St. Lucia, Queensland, Australia.
authors.forename: Páraic
authors.initials: P
authors.lastname: O Cuív
authors.forename: Rajesh
authors.initials: R
authors.lastname: Gupta
authors.forename: Hareshwar P
authors.initials: HP
authors.lastname: Goswami
authors.forename: Mark
authors.initials: M
authors.lastname: Morrison
mesh_terms: D002480:Cellulase / Q000378:metabolism*; D048013:Acetivibrio thermocellus / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000378:metabolism*; D055550:Protein Stability; D015843:Serpins / Q000737:chemistry / Q000378:metabolism*; D020860:Subtilisin / Q000037:antagonists & inhibitors*
chemical_list: D009097:Multienzyme Complexes; D015843:Serpins; C473132:cellulosome, Clostridium; D002480:Cellulase; D020860:Subtilisin