title: Gingival enlargement as an early diagnostic indicator in therapy-related acute myeloid leukemia: A rare case report and review of literature.
abstract: Treatment for Hodgkin's lymphoma (HL) has resulted in excellent survival rates but is associated with increased risks of secondary therapy-related acute myeloid leukemia (t-AML). Gingival enlargement associated with bleeding and ulceration is the most common rapidly appearing oral manifestations of leukemic involvement. An 8 months pregnant patient reported with generalized gingival enlargement, with localized cyanotic and necrotic papillary areas. Co-relating the hematological report with the oral lesions and her past medical history of HL, a diagnosis of t-AML secondary to treatment for HL was made by the oncologist. As oral lesions are one of the initial manifestations of acute leukemia, they may serve as a significant diagnostic indicator for the dental surgeons and their important role in diagnosing and treating such cases. Furthermore, this case report highlights the serious complication of t-AML subsequent to HL treatment and the important role that a general and oral health care professional may play in diagnosing and treating such cases.
authors.affiliation: Department of Periodontics, Bapuji Dental College and Hospital, Davangere, Karnataka, India.
authors.forename: Triveni M
authors.initials: TM
authors.lastname: Gowda
authors.forename: Raison
authors.initials: R
authors.lastname: Thomas
authors.forename: Shruthi M
authors.initials: SM
authors.lastname: Shanmukhappa
authors.forename: Garima
authors.initials: G
authors.lastname: Agarwal
authors.forename: Dhoom S
authors.initials: DS
authors.lastname: Mehta
keywords: Acute myeloid leukemia; Hodgkin's lymphoma; chemotherapy; gingival overgrowth; therapy related