title: The iron-catalyzed construction of 2-aminopyrimidines from alkynenitriles and cyanamides.
abstract: Several cycloaddition catalysts and reagents were surveyed for their effectiveness toward cyclizing alkynenitriles with cyanamides. Catalytic amounts of FeI2, (iPr)PDAI and Zn were found to effectively catalyze the [2+2+2] cycloaddition of a variety of cyanamides and alkynenitriles to afford bicyclic 2-aminopyrimidines.
authors.affiliation: The University of Utah, 315 S. 1400 E. RM. 2020, Salt Lake City, UT 84102, USA.
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Lane
authors.forename: Minh H
authors.initials: MH
authors.lastname: Nguyen
authors.forename: Brendan R
authors.initials: BR
authors.lastname: D'Souza
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Spahn
authors.forename: Janis
authors.initials: J
authors.lastname: Louie