title: Cervical dysplasia and pre-term birth in San Juan city hospital: a cohort retrospective study.
abstract: Cervical dysplasia alters the release of cytokines and inflammatory mediators in pregnant woman with cervical dysplasia. This study evaluates a cohort of pregnant patients screened for cervical dysplasia to determine the relationship between cervical dysplasia and preterm labor (PTL).
  
  
  METHODS
  Retrospective chart review of pregnant patients screened for cervical dysplasia at the San Juan City Hospital between October 2006 and December 2010. Patients with low or high-grade squamous intraepithelial lesions (LGSIL or HGSIL, respectively) were evaluated with colposcopy. Primary outcome was the event of PTL and the risk factor evaluated was presence of cervical dysplasia.
  
  
  RESULTS
  A total of 2,059 patients were screened for cervical dysplasia and 59 were evaluated with colposcopy due to LGSIL or HGSIL. From those, 29% were negative for intraepithelial lesions and malignancy (NILM), 54% had cervical intraepithelial neoplasia (CIN)-1, 17% where diagnosed as CIN-2/3 where no invasive cervical cancer was identified. In the group of NILM, 24% had PTL compared to 18% in patients who screened negative on initial cytological evaluation. In cases where CIN-1 was confirmed by colposcopy 28% had PTL compared with 40% in patients with CIN-2/3. Other risk factors associated with PTL were not significantly different among the groups.
  
  
  CONCLUSIONS
  Cervical dysplasia in pregnancy may represent an increase risk for premature labor.
authors.affiliation: Obstetrics and Gynecology Residency Program, San Juan City Hospital, Puerto Rico Medical Center, San Juan Puerto Rico.
authors.forename: Axel
authors.initials: A
authors.lastname: Torres
authors.forename: Edgardo Rivera
authors.initials: ER
authors.lastname: Rosa
authors.forename: Keimari
authors.initials: K
authors.lastname: Méndez
authors.forename: Ana
authors.initials: A
authors.lastname: Menéndez
authors.forename: Josefina
authors.initials: J
authors.lastname: Romaguera
mesh_terms: D015331:Cohort Studies; D005260:Female; D006786:Hospitals, Urban; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology*; D011647:Puerto Rico; D012189:Retrospective Studies; D002578:Uterine Cervical Dysplasia / Q000150:complications*