title: Pre- and postnatal imaging of early cerebral damage in Sturge-Weber syndrome.
abstract: A case of prenatal diagnosis of Sturge-Weber syndrome associated with polymicrogyria is reported. The diagnosis was based on a unique association with unilateral hemispheric gyriform calcification, focal hemispheric atrophy and white matter changes on prenatal imaging including ultrasound and MRI. Polymicrogyria, which is exceptionally associated with Sturge-Weber syndrome, is suggestive of and reinforces the hypothesis of early impairment of the cerebral microvasculature related to leptomeningeal angioma, which may lead to abnormal cerebral development as early as the second trimester of pregnancy.
authors.affiliation: Pediatric and Fetal Imaging, Hôpital Femme Mère Enfant, 59, boulevard Pinel, 69677, Lyon-Bron, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Cagneaux
authors.forename: Vincent
authors.initials: V
authors.lastname: Paoli
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Blanchard
authors.forename: Dorothée
authors.initials: D
authors.lastname: Ville
authors.forename: Laurent
authors.initials: L
authors.lastname: Guibaud
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D054220:Malformations of Cortical Development / Q000175:diagnosis* / Q000196:embryology*; D013341:Sturge-Weber Syndrome / Q000175:diagnosis* / Q000196:embryology*; D016216:Ultrasonography, Prenatal / Q000379:methods*