title: Potential prevention of pacing-induced heart failure using simple pacemaker programming algorithm.
abstract: BACKGROUND
  Right ventricular pacing (RVP) causes ventricular desynchronization and may lead to the development of heart failure (HF). Prolongation of atrioventricular delay (AVD) in DDDR pacemakers reduces unnecessary RV stimulation. The aim of the study was to verify the influence of RVP reduction on HF symptoms.
  
  
  METHODS
  The study comprised 31 patients (17 men, mean age: 71.6 ± 8 yrs) with DDDR pacemaker implanted due to sinus node dysfunction (SND). At baseline, 28 patients did not present any symptoms of HF. Three patients were in NYHA class II. Patients were randomized either to 150 ms AVD or to minimizing right ventricular pacing (MRVP). Crossing over to the alternate mode took place after 4 months. Cardiopulmonary exercise test (CPX), echocardiography (ECHO) and BNP measurements were done before pacemaker implantation, after 4 and 8 months.
  
  
  RESULTS
  The percentage of RVP was significantly higher in 150 ms AVD than in MRVP: 81.7 ± 22.6 versus 14.2±20.5%, P < 0.0001. Patients with 150 ms mode had worse CPX parameters than those with MRVP mode: peak oxygen uptake was 14.2±4.3 versus 19.9±6.3 ml/kg per min, P = 0.0001, higher BNP concentrations: 72.3±48.3 versus 49.4±43.9 pg/ml, P = 0.001 and worse left ventricle [LV] function: ejection fraction: 53.2±6.7 versus 57.3±5.5%, P < 0.0001; LV diastolic diameter: 4.86±0.52 versus 4.66±0.5 cm, P < 0.01.
  
  
  CONCLUSIONS
  Predominant RVP in patients without symptoms of HF at baseline may be responsible for worse performance in cardiopulmonary exercise test, higher BNP concentrations and impairment of LV function. Specific DDDR pacemaker programming promotes intrinsic AV conduction and may prevent the development of pacing-induced HF.
authors.affiliation: Second Coronary Artery Disease Department, Institute of Cardiology, Warsaw, Poland. tchwyczko@ikard.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Chwyczko
authors.forename: Rafał
authors.initials: R
authors.lastname: Dąbrowski
authors.forename: Aleksander
authors.initials: A
authors.lastname: Maciąg
authors.forename: Maciej
authors.initials: M
authors.lastname: Sterliński
authors.forename: Edyta
authors.initials: E
authors.lastname: Smolis-Bąk
authors.forename: Anna
authors.initials: A
authors.lastname: Borowiec
authors.forename: Ilona
authors.initials: I
authors.lastname: Kowalik
authors.forename: Andrada
authors.initials: A
authors.lastname: Łabęcka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Jankowska
authors.forename: Marek
authors.initials: M
authors.lastname: Kośmicki
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Janas
authors.forename: Mariusz
authors.initials: M
authors.lastname: Pytkowski
authors.forename: Hanna
authors.initials: H
authors.lastname: Szwed
mesh_terms: D000368:Aged; D000465:Algorithms; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects* / Q000379:methods; D018592:Cross-Over Studies; D015150:Echocardiography, Doppler / Q000379:methods; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control*; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000032:analysis; D010138:Pacemaker, Artificial; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D012804:Sick Sinus Syndrome / Q000175:diagnosis* / Q000628:therapy*; D016037:Single-Blind Method; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000517:prevention & control
chemical_list: D020097:Natriuretic Peptide, Brain
keywords: BNP; cardiopulmonary exercise; echocardiography; pacing; sinus node dysfunction