title: Diagnostic value of minor salivary glands biopsy for the detection of Lewy pathology.
abstract: The recent demonstration of the presence of Lewy pathology in the submandibular glands of Parkinson's disease (PD) patients prompted us to evaluate the diagnostic performance of minor salivary gland biopsy for PD. Minor salivary glands were examined for Lewy pathology using phosphorylated alpha-synuclein antibody in 16 patients with clinically diagnosed PD and 11 control subjects with other neurological disorders. Abnormal accumulation of alpha-synuclein was found in 3 out of 16 PD patients. Two control subjects exhibited weak phosphorylated alpha-synuclein immunoreactivity. Our results do not support the use of minor salivary glands biopsy for the detection of Lewy pathology in living subjects.
authors.affiliation: CHU Nantes, Department of Neurology, Nantes, F-44093, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Folgoas
authors.forename: Thibaud
authors.initials: T
authors.lastname: Lebouvier
authors.forename: Laurène
authors.initials: L
authors.lastname: Leclair-Visonneau
authors.forename: Maria-Graciela
authors.initials: MG
authors.lastname: Cersosimo
authors.forename: Annick
authors.initials: A
authors.lastname: Barthelaix
authors.forename: Pascal
authors.initials: P
authors.lastname: Derkinderen
authors.forename: Franck
authors.initials: F
authors.lastname: Letournel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology*
keywords: Alpha-synuclein; Lewy bodies; Lewy neurites; Minor salivary glands biopsy; Parkinson's disease; Salivary glands