title: The effect of continuous subcutaneous recombinant PTH (1-34) infusion during pregnancy on calcium homeostasis - a case report.
abstract: OBJECTIVE
  We describe calcium homeostasis during pregestation and gestation in a woman with iatrogenic hypoparathyroidism, treated with continuous subcutaneous recombinant parathyroid hormone (PTH) (1-34) infusion.
  
  
  RESULTS
  The requirement for PTH did not fluctuate much during pregnancy and was essential for maintaining normal calcium and phosphorus serum levels.
  
  
  CONCLUSIONS
  This study documents the insufficiency of PTH-related protein (PTHrP) or other gestation-related hormones to compensate for PTH deficiency in hypoparathyroid women, and the successful utilization of continuous subcutaneous recombinant PTH (1-34) infusion to achieve normal calcium homeostasis during gestation. Clinical trials with PTH replacement in such circumstances are warranted.
authors.affiliation: Institute of Endocrinology, Sheba Medical Center, Ramat Gan, Israel.
authors.forename: Jacob
authors.initials: J
authors.lastname: Ilany
authors.forename: Iris
authors.initials: I
authors.lastname: Vered
authors.forename: Ohad
authors.initials: O
authors.lastname: Cohen
mesh_terms: D000328:Adult; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007011:Hypoparathyroidism / Q000188:drug therapy* / Q000209:etiology; D007049:Iatrogenic Disease; D007260:Infusion Pumps; D055104:Infusions, Subcutaneous; D010281:Parathyroid Hormone / Q000008:administration & dosage*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage; D013965:Thyroidectomy / Q000009:adverse effects
chemical_list: D010281:Parathyroid Hormone; D011994:Recombinant Proteins; D002118:Calcium