title: Transcatheter aortic valve replacement for advanced valvular disease in active SLE and APS.
abstract: Valvular heart disease is a relatively common finding in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS), sometimes necessitating valve surgery. Valve replacement may result in significant early and late morbidity and mortality. Surgical risks are even greater when co-morbid conditions including active SLE and renal involvement are present. This is the first report of the successful use of transcatheter aortic valve replacement (TAVR) for severe critical aortic stenosis in a patient with active SLE, renal failure and APS. TAVR may represent an additional, safer, approach to cardiac valve replacement in appropriately selected patients particularly where surgical risk is high and active disease present.
authors.affiliation: Department of Internal Medicine, University of Minnesota Medical School, Minneapolis, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Bert
authors.forename: M
authors.initials: M
authors.lastname: Abdullah
authors.forename: T G
authors.initials: TG
authors.lastname: Dahle
authors.forename: E
authors.initials: E
authors.lastname: Gertner
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001021:Aortic Valve / Q000601:surgery*; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*
keywords: Systemic lupus erythematosus; antiphospholipid syndrome; cardiovascular disease