title: Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - are they beneficial to the host?
abstract: Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that can result in significant human morbidity. Within the cornea, it was thought the initial recognition of the pathogen was through Toll-like receptors expressed on/in resident cells that then elicit pro-inflammatory cytokine production, activation of anti-viral pathways, and recruitment of leukocytes. However, our lab has uncovered a novel, TLR-independent innate sensor that supersedes TLR induction of anti-viral pathways following HSV-1 infection. In addition, we have also found HSV-1 induces the genesis of lymphatic vessels into the cornea proper by a mechanism independent of TLRs and unique in the field of neovascularization. This review will focus on these two innate immune events during acute HSV-1 infection of the cornea.
authors.affiliation: Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: Katie
authors.initials: K
authors.lastname: Bryant-Hudson
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Conrady
authors.forename: Daniel J J
authors.initials: DJ
authors.lastname: Carr
mesh_terms: D000818:Animals; D003316:Corneal Diseases / Q000276:immunology* / Q000821:virology; D015828:Eye Infections, Viral / Q000276:immunology* / Q000821:virology; D006561:Herpes Simplex / Q000276:immunology* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology*; D042583:Lymphangiogenesis / Q000276:immunology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: D007370:Interferon Type I; D042461:Vascular Endothelial Growth Factor A
keywords: Cornea; Innate immunity; Lymphatic vessel; Type I IFN; Virus