title: The role of miRNA in inflammation and autoimmunity.
abstract: miRNAs are small non-coding RNA molecules that modulate the expression of multiple protein-encoding genes at the post-transcriptional level. They have recently been recognized as powerful regulators of numerous genes and pathways in the pathogenesis of inflammatory and autoimmune diseases. The targets of most miRNAs remain unknown and their roles in biological processes such as cell differentiation, proliferation, and death (apoptosis) are not clearly understood. In this review we will discuss how certain candidate miRNAs affect inflammatory and immune mediated diseases by regulating their cellular and molecular targets. We focused the influence of gender and sex hormones on miRNA. We believe that understanding the role of miRNAs could shed light on the cause and progression of many inflammatory and autoimmune diseases and eventually lay the groundwork for therapeutic options.
authors.affiliation: Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1670, USA. Electronic address: rpsingh@mednet.ucla.edu.
authors.forename: Ram Pyare
authors.initials: RP
authors.lastname: Singh
authors.forename: Israel
authors.initials: I
authors.lastname: Massachi
authors.forename: Sudhir
authors.initials: S
authors.lastname: Manickavel
authors.forename: Satendra
authors.initials: S
authors.lastname: Singh
authors.forename: Nagesh P
authors.initials: NP
authors.lastname: Rao
authors.forename: Sascha
authors.initials: S
authors.lastname: Hasan
authors.forename: Deborah K
authors.initials: DK
authors.lastname: Mc Curdy
authors.forename: Sherven
authors.initials: S
authors.lastname: Sharma
authors.forename: David
authors.initials: D
authors.lastname: Wong
authors.forename: Bevra H
authors.initials: BH
authors.lastname: Hahn
authors.forename: Hamida
authors.initials: H
authors.lastname: Rehimi
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D015551:Autoimmunity; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000276:immunology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: Autoimmunity; Cancer; MicroRNA; Rheumatoid arthritis and Sjögren syndrome; Sex hormones; Systemic lupus erythematosus