title: Diabetes mellitus and risk of cancer in Takayama: a population-based prospective cohort study in Japan.
abstract: Diabetes mellitus (DM) has been reported to be associated with an increased risk of site-specific cancers; however, few studies have assessed associations of DM with both total and site-specific cancers in Japan. We examined the association of a history of DM with cancer incidence in a population-based prospective cohort study in Japan. A total of 14 173 men and 16 547 women over 35 years old, who completed a self-administered baseline questionnaire in 1992, were followed up for cancer incidence from September 1992 to March 2008. At baseline, 6.3% men and 2.9% women had a history of diabetes. A total of 1974 men and 1514 women were identified as newly diagnosed with cancer. Hazard ratios (HR) and 95% confidence intervals (CI) were determined using Cox proportional hazards models. After controlling for potential confounders, men with DM had a modest risk increase of total cancer occurrence compared with those without DM (HR, 1.09; 95% CI, 0.93-1.29). Increased risk of cancer of the liver (HR, 2.18; 95% CI, 1.27-3.74), bile duct (HR, 2.17; 95% CI, 1.01-4.66), and larynx (HR, 3.61; 95% CI, 1.16-11.2) in diabetic men were observed. In women, significant increased risk of total cancer (HR, 1.35; 95% CI, 1.06-1.73) and stomach cancer (HR, 2.15; 95% CI, 1.30-3.54) were observed among diabetic subjects. These data suggest that people with DM may be at increased risk of both total and some site-specific cancers.
authors.affiliation: Department of Epidemiology and Preventive Medicine, Gifu University, Graduate School of Medicine, Gifu, Japan.
authors.forename: Kozue
authors.initials: K
authors.lastname: Nakamura
authors.forename: Keiko
authors.initials: K
authors.lastname: Wada
authors.forename: Yuya
authors.initials: Y
authors.lastname: Tamai
authors.forename: Michiko
authors.initials: M
authors.lastname: Tsuji
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kawachi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hori
authors.forename: Naoharu
authors.initials: N
authors.lastname: Takeyama
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tanabashi
authors.forename: Shogen
authors.initials: S
authors.lastname: Matsushita
authors.forename: Naoki
authors.initials: N
authors.lastname: Tokimitsu
authors.forename: Chisato
authors.initials: C
authors.lastname: Nagata
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000235:genetics; D015331:Cohort Studies; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007822:Laryngeal Neoplasms / Q000235:genetics; D008019:Life Style; D008113:Liver Neoplasms / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012306:Risk; D012737:Sex Factors; D012959:Socioeconomic Factors; D013274:Stomach Neoplasms / Q000235:genetics; D011795:Surveys and Questionnaires