title: Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease.
abstract: BACKGROUND
  Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circulating A-FABP level with severity of myocardial perfusion abnormalities analyzed by Tl-201 dipyridamole single-photon emission computed tomography.
  
  
  METHODS
  A total of 170 patients with coronary artery disease (CAD) from cardiovascular clinics were enrolled in the study. Serum A-FABP levels, echocardiography, and stress myocardial perfusion imaging results were analyzed.
  
  
  RESULTS
  Compared with the patients with mild CAD (summed stress score [SSS] ≤ 8), those with moderate to severe CAD (SSS > 8) had significantly higher A-FABP concentrations. However, the difference was attenuated in the subgroup of patients with heart failure. In the correlation analyses, A-FABP level was correlated with age, body mass index, waist circumference, levels of creatinine, fasting glucose, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, adiponectin, and several echocardiographic parameters, including left ventricular ejection fraction. Multivariate logistic regression analysis demonstrated that the A-FABP level was not only associated with higher SSS (odds ratio, 1.30; 95% confidence interval [CI], 1.01-1.69; P = 0.048), but also an independent risk factor for heart failure (odds ratio 2.71, 95% CI, 1.23-5.94; P = 0.013).
  
  
  CONCLUSIONS
  Serum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in our patients with CAD.
authors.affiliation: Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan.
authors.forename: Chi-Lun
authors.initials: CL
authors.lastname: Huang
authors.forename: Yen-Wen
authors.initials: YW
authors.lastname: Wu
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Wu
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.forename: Yu-Chin
authors.initials: YC
authors.lastname: Wu
authors.forename: Pei-Ying
authors.initials: PY
authors.lastname: Hsu
authors.forename: Yuh-Shiun
authors.initials: YS
authors.lastname: Jong
authors.forename: Wei-Shiung
authors.initials: WS
authors.lastname: Yang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D025401:Echocardiography, Stress; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D055414:Myocardial Perfusion Imaging; D012720:Severity of Illness Index; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging; D016277:Ventricular Function, Left
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins