title: Phenylalanine-containing cyclic dipeptides--the lowest molecular weight hydrogelators based on unmodified proteinogenic amino acids.
abstract: Cyclic dipeptides (diketopiperazines - DKPs) that are based on the proteinogenic amino acid phenylalanine in combination with serine, cysteine, glutamate, histidine and lysine are described as simple and remarkable low molecular weight hydrogelators. Blends of selected DKPs show remarkable pH-dependent properties and can be applied as easy to tune materials in drug delivery.
authors.affiliation: University of Tuebingen, Institute of Organic Chemistry, Auf der Morgenstelle 18, D-72076 Tuebingen, Germany.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Kleinsmann
authors.forename: Boris J
authors.initials: BJ
authors.lastname: Nachtsheim
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D004151:Dipeptides / Q000737:chemistry* / Q000378:metabolism; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008970:Molecular Weight; D010649:Phenylalanine / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010649:Phenylalanine