title: Androgen-producing steroid cell ovarian tumor in a young woman and subsequent spontaneous pregnancy.
abstract: OBJECTIVE
  To describe the presentation and fertility sparing treatment of a young woman found to have a steroid cell tumor not otherwise specified (NOS) and her spontaneous pregnancy and delivery shortly after surgery.
  
  
  METHODS
  A 20-year-old Hispanic female presented with hirsuitism, virilization, and elevated androgen levels (testosterone 328 ng/dL) and was wrongly diagnosed with polycystic ovarian syndrome. Four months later she sought a second opinion. Her androgens were as follows: testosterone level 485 ng/dL, androstenedione 1,738 ng/dL and DHEA 1,459 ng/dL. She had normal levels of progesterone, estradiol, and DHEA-SO4. On transvaginal ultrasound she had a solid-appearing right ovarian mass. She underwent fertility sparing surgery with a laparoscopic right oophorectomy.
  
  
  RESULTS
  Gross and histological pathology confirmed a benign steroid cell tumor NOS. She had rapid normalization of all androgens 13 days after surgery. She had spontaneous resumption of menses 4 months later. She conceived despite using emergency contraception approximately 9 months following surgery and delivered a healthy boy at term without complication.
  
  
  CONCLUSIONS
  Prompt evaluation for an androgen producing tumor should be performed when testosterone levels are greater than 200 ng/dL. Pregnancy following removal of this rare tumor has not previously been reported.
authors.affiliation: University of Oklahoma College of Medicine, Oklahoma City, OK, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Sielert
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.forename: Rajeswari
authors.initials: R
authors.lastname: Nagarathinam
authors.forename: Latasha B
authors.initials: LB
authors.lastname: Craig
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood* / Q000473:pathology / Q000601:surgery; D011374:Progesterone / Q000097:blood; D013739:Testosterone / Q000097:blood*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D013739:Testosterone; D011374:Progesterone; D004958:Estradiol