title: Sustained remission of antineutrophil cytoplasmic antibody-mediated glomerulonephritis and nephrotic syndrome in mixed connective tissue disease.
abstract: A woman diagnosed with mixed connective tissue disease (MCTD) developed an anti-myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) and nephrotic syndrome with normal serum creatinine. Percutaneous kidney biopsy showed pauci-immune glomerulonephritis with superimposed immune complex deposition. After treatment with cyclophophamide and prednisone, proteinuria decreased progressively to a level of 0.4 g/g creatinine, ANCA became undetectable, while serum creatinine remained normal seven years after the beginning of treatment. Sustained remission of nephrotic proteinuria with preserved renal function may follow treatment of ANCA-mediated disease developing in patients with MCTD.
authors.affiliation: Division of Rheumatology, University of New Mexico School of Medicine; USA.
authors.forename: Konstantin N
authors.initials: KN
authors.lastname: Konstantinov
authors.forename: Alexis A
authors.initials: AA
authors.lastname: Harris
authors.forename: Marc
authors.initials: M
authors.lastname: Barry
authors.forename: Glen H
authors.initials: GH
authors.lastname: Murata
authors.forename: Antonios H
authors.initials: AH
authors.lastname: Tzamaloukas
keywords: Antimyeloperoxidase; Antineutrophil cytoplasmic antibodies; Mixed-connective tissue disease; Nephrotic syndrome; Pauci-immune glomerulonephritis