title: Serum soluble triggering receptor on myeloid cells-1 (sTREM-1) is elevated in systemic lupus erythematosus but does not distinguish between lupus alone and concurrent infection.
abstract: We sought to determine serum triggering receptor expressed on myeloid cell-1 (sTREM-1) level in a cohort of patients with systemic lupus erythematosus (SLE). Serum sTREM-1 level of 98 patients with SLE and 49 healthy controls was assayed by ELISA. Serum sTREM-1 level was significantly elevated in a cohort of 78 unselected consecutively recruited patients with SLE (mean 1.1 ± 2.8 ρg/ml, median 0.02 ρg/ml) compared to that of the controls (mean 0.11 ± 0.3 ρg/ml, median 0 ρg/ml; p < 0.0001). We also determined serum sTREM-1 level of 20 SLE patients with a concurrent infection (mean 0.6 ± 1.1 ρg/ml, median 0.12 ρg/ml) and found it not statistically significant compared with that of the patients without infection. Serum sTREM-1 level did not correlate with SLE disease activity. Our finding of elevated serum sTREM-1 level suggests an increased shedding of TREM-1 in SLE and a possible novel pathway of innate immune response in autoimmunity.
authors.affiliation: Beilinson Hospital, Rabin Medical Center, Tel Aviv University, Petach Tikva, Israel, ymolad@post.tau.ac.il.
authors.forename: Yair
authors.initials: Y
authors.lastname: Molad
authors.forename: Elisheva
authors.initials: E
authors.lastname: Pokroy-Shapira
authors.forename: Tania
authors.initials: T
authors.lastname: Kaptzan
authors.forename: Assaf
authors.initials: A
authors.lastname: Monselise
authors.forename: Michal
authors.initials: M
authors.lastname: Shalita-Chesner
authors.forename: Yehudit
authors.initials: Y
authors.lastname: Monselise
mesh_terms: D000328:Adult; D015331:Cohort Studies; D060085:Coinfection / Q000097:blood; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000097:blood*; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000097:blood*; D051217:Toll-Like Receptor 9 / Q000276:immunology; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C495371:TLR9 protein, human; C408842:TREM1 protein, human; D051217:Toll-Like Receptor 9; D000073871:Triggering Receptor Expressed on Myeloid Cells-1