title: Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice.
abstract: BACKGROUND
  In our previous study, the aqueous extract of Channa striatus (family: Channidae) fillet (AECSF) showed an antidepressant-like effect in mice. However, the mechanism of the antidepressant-like effect is unknown.
  
  
  OBJECTIVE
  The objective of this study was to explore the involvement of monoamines in the antidepressant-like effect of AECSF in mice.
  
  
  METHODS
  AECSF was prepared by steaming the fillets of C. striatus. The male ICR mice were pretreated with various monoaminergic antagonists viz., p-chlorophenylalanine (100 mg/kg, i.p.), prazosin (1 mg/kg, i.p.) and yohimbine (1 mg/kg, i.p.), SCH23390 (0.05 mg/kg, s.c.) and sulpiride (50 mg/kg, i.p.) followed by treatment with AECSF and tested in tail suspension test (TST). Two-way ANOVA with Tukey test were used at p < 0.05 for significance.
  
  
  RESULTS
  The pretreatments with p-chlorophenylalanine, prazosin and yohimbine, but not with SCH23390 and sulpiride, were able to reverse the antidepressant-like effect of AECSF in TST.
  
  
  CONCLUSIONS
  The antidepressant-like effect of AECSF may be mediated through the serotonergic and noradrenergic systems and not through the dopaminergic system.
authors.affiliation: Department of Human Anatomy and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM Serdang, Selangor, Malaysia. taufik@medic.upm.edu.my.
authors.forename: A M
authors.initials: AM
authors.lastname: Saleem
authors.forename: M
authors.initials: M
authors.lastname: Taufik Hidayat
authors.forename: A M M
authors.initials: AM
authors.lastname: Jais
authors.forename: S
authors.initials: S
authors.lastname: Fakurazi
authors.forename: M A M
authors.initials: MA
authors.lastname: Moklas
authors.forename: M R
authors.initials: MR
authors.lastname: Sulaiman
authors.forename: Z
authors.initials: Z
authors.lastname: Amom
authors.forename: R
authors.initials: R
authors.lastname: Basir
mesh_terms: D000322:Adrenergic Agonists / Q000494:pharmacology; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology; D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology; D045424:Complex Mixtures / Q000494:pharmacology*; D003863:Depression / Q000378:metabolism; D065127:Dopamine D2 Receptor Antagonists / Q000494:pharmacology; D010134:Fenclonine / Q000031:analogs & derivatives / Q000494:pharmacology; D005399:Fishes; D019417:Hindlimb Suspension; D008297:Male; D008813:Mice, Inbred ICR; D011224:Prazosin / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D000322:Adrenergic Agonists; D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000928:Antidepressive Agents; D001552:Benzazepines; D045424:Complex Mixtures; D065127:Dopamine D2 Receptor Antagonists; C534628:SCH 23390; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C020261:4-chlorophenylalanine methyl ester; D015016:Yohimbine; D012701:Serotonin; D010134:Fenclonine; D011224:Prazosin