title: Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma.
abstract: Data mining on public domain identified that CDC28 protein kinase regulatory subunit 1B (CKS1B) transcript was highly expressed in nasopharyngeal carcinoma (NPC). The expression of CKS1B protein and its clinicopathological associations in patients with NPC were further evaluated. Immunoexpression of CKS1B was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The correlations between CKS1B immunoexpression levels and clinicopathological features, as well as patient survivals, were analyzed. High CKS1B expression (49.2%) was correlated with the 7th American Joint Committee on Cancer (AJCC) stage (p = 0.014). In multivariate analyses, high CKS1B expression emerged as an independent prognostic factor for worse disease-specific survival (p < 0.001), metastasis-free survival (p < 0.001), and local recurrence-free survival (p = 0.001). High expression of CKS1B is common and associated with adverse prognostic factors and might confer tumor aggressiveness through dysregulation of the cyclin-dependent protein kinase (intrinsic regulatory activity) during cell cycle progression.
authors.affiliation: Department of Radiation Oncology, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Sung-Wei
authors.initials: SW
authors.lastname: Lee
authors.forename: Ching-Yih
authors.initials: CY
authors.lastname: Lin
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Tian
authors.forename: Ding-Ping
authors.initials: DP
authors.lastname: Sun
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Lin
authors.forename: Li-Tzong
authors.initials: LT
authors.lastname: Chen
authors.forename: Chung-Hsi
authors.initials: CH
authors.lastname: Hsing
authors.forename: Chiang-Ting
authors.initials: CT
authors.lastname: Huang
authors.forename: Han-Ping
authors.initials: HP
authors.lastname: Hsu
authors.forename: Hsuan-Ying
authors.initials: HY
authors.lastname: Huang
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Wu
authors.forename: Chien-Feng
authors.initials: CF
authors.lastname: Li
authors.forename: Yow-Ling
authors.initials: YL
authors.lastname: Shiue
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D042846:CDC2-CDC28 Kinases / Q000235:genetics / Q000378:metabolism*; D002277:Carcinoma; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; C093090:CKS1B protein, human; D042846:CDC2-CDC28 Kinases
keywords: CDC28 protein kinase regulatory subunit 1B; CKS1B; Nasopharyngeal carcinoma; survival