title: Cytotoxic lignans from Viburnum foetidum.
abstract: Two new lignans, 3,4,4'-trihydroxy-3',9-dimethoxy-9,9'-epoxylignan (1), 3,4'-dihydroxy-3',4, 9-trimethoxy-9,9'-epoxylignan (2), together with one known compound, 4,4'-dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan (3), were isolated from the 95 % EtOH extract of Viburnum foetidum. The structures of the two new compounds were elucidated on the basis of 1D, 2D-NMR, and mass spectral analysis. All the lignans were in vitro evaluated for their cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15).
authors.affiliation: Department of Anesthesiology, No. 181 Hospital of PLA, Guilin, 541002, GuangXi Province, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Yuanguo
authors.initials: Y
authors.lastname: Luo
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.forename: Jun
authors.initials: J
authors.lastname: Zeng
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Chunlin
authors.initials: C
authors.lastname: Hu
mesh_terms: D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D027925:Viburnum / Q000737:chemistry*
chemical_list: D003603:Cytotoxins; D017705:Lignans; D010936:Plant Extracts