title: (18)F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography findings are different between invasive and noninvasive pulmonary aspergillosis.
abstract: OBJECTIVE
  Invasive pulmonary aspergillosis (IPA) is a significant cause of morbidity and mortality especially in immunocompromised patients, and extensive work has been done in the field of diagnostic imaging. The purpose of our study was to evaluate functional metabolic image findings of F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) in the patients with invasive and noninvasive forms of pulmonary aspergillosis (IPA and NIPA, respectively).
  
  
  METHODS
  We retrospectively reviewed 24 consecutive patients who had pulmonary aspergillosis among the patients who underwent F-FDG PET/CT to evaluate lung mass or fever of unknown origin. Demographic feature, multiplicity, visually analyzed F-FDG uptake patterns (isometabolic halo, isometabolic nodule, hypermetabolic nodule, or other), and the peak standardized uptake value (SUVpeak) of the pulmonary lesions on PET/CT were evaluated.
  
  
  RESULTS
  Of these 24 patients, 8 were diagnosed with IPA and 16 with NIPA. Patients with IPA were significantly younger (48 vs 62 years), and immunocompromised conditions were more frequently observed in these cases (88% vs 6%). Multiple lesions were noted in 50% (4 of 8) and 19% (3 of 16) of IPA and NIPA patients, respectively, and the predominant patterns on F-FDG PET/CT were the hypermetabolic nodule pattern (6 of 8 patients, 75%) and the isometabolic halo pattern (8 of 16 patients, 50%) in IPA and NIPA patients, respectively. The isometabolic halo pattern was not observed in IPA patients. The median SUVpeak was 4.5 (range, 1.3-8.9) and 1.6 (range, 0.5-3.1) in IPA and NIPA, respectively.
  
  
  CONCLUSIONS
  F-FDG PET/CT findings differ between IPA and NIPA patients. Pulmonary aspergillosis in immunocompromised status with a hypermetabolic nodule pattern on F-FDG PET/CT seems to have high possibility of IPA. In contrast, an isometabolic halo pattern and an isometabolic nodule pattern on F-FDG PET/CT seem to have high possibility of NIPA.
authors.affiliation: Department of Nuclear Medicine, Hanyang University Hospital, Seoul, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Jung-Wan
authors.initials: JW
authors.lastname: Yoo
authors.forename: Minyoung
authors.initials: M
authors.lastname: Oh
authors.forename: Seol Hoon
authors.initials: SH
authors.lastname: Park
authors.forename: Tae Sun
authors.initials: TS
authors.lastname: Shim
authors.forename: Yun Young
authors.initials: YY
authors.lastname: Choi
authors.forename: Jin-Sook
authors.initials: JS
authors.lastname: Ryu
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D009361:Neoplasm Invasiveness; D049268:Positron-Emission Tomography; D055732:Pulmonary Aspergillosis / Q000473:pathology*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18