title: [A case of synchronous liver metastasis originating from advanced gastric cancer treated with combination chemotherapy involving S-1 and surgical intervention].
abstract: A 71-year-old man was diagnosed with gastric cancer[cT4, cN0, cH1(S6), cP0, cM0, cStage IV]and underwent distal gastrectomy with cholecystectomy, partial colectomy for the invasion to the mesentery of transverse colon, and partial hepatectomy for metastatic liver tumor(segment 6). Although chemotherapy with S-1+CDDP was administered after the operation, a recurrent lesion appeared in the remnant of liver(segment 6). The chemotherapy regimen was changed to S-1+CPT-11. Since the only recurrent tumor was found in the remnant liver, it was resected. After S-1 chemotherapy, no recurrence has been detected since the first operation. A good outcome was obtained for this patient with synchronous liver metastasis and the recurrence remnant liver originating from gastric cancer, possibly as a result of the combination of chemotherapy and surgical resection for the primary lesion and liver metastasis.
authors.affiliation: Second Dept. of Surgery, Hamamatsu University School of Medicine, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Takeda
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ori
authors.forename: Kimio
authors.initials: K
authors.lastname: Ohishi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sunayama
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005743:Gastrectomy; D006498:Hepatectomy; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin