title: Review of direct renin inhibition by aliskiren.
abstract: Numerous clinical studies have been conducted to analyse the ability of renin-angiotensin system blockade to lower blood pressure and to reduce end-organ damage. In addition to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, direct renin inhibitors emerged as an attractive option to inhibit the renin-angiotensin system and thus to prevent cardiovascular damage. Based on the publication of the most recent available results of ALTITUDE and ASTRONAUT, we review the data with respect to the direct renin inhibitor aliskiren given as an antihypertensive drug, in monotherapy and combination therapy, and the most recent publication analysing the effects of aliskiren on end-organ protection.
authors.affiliation: Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Friedrich
authors.forename: Roland E
authors.initials: RE
authors.lastname: Schmieder
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D023381:Endpoint Determination; D005650:Fumarates / Q000494:pharmacology*; D006801:Humans; D012083:Renin / Q000378:metabolism; D016896:Treatment Outcome; D000092502:Renin Inhibitors
chemical_list: D000577:Amides; D000959:Antihypertensive Agents; D005650:Fumarates; D012083:Renin; D000092502:Renin Inhibitors; C446481:aliskiren
keywords: Blood pressure; RAS; acute and chronic heart failure; cardiovascular; direct renin inhibition; end-organ protection; renal dysfunction