title: The roles of melanin-concentrating hormone in energy balance and reproductive function: Are they connected?
abstract: Melanin-concentrating hormone (MCH) is an anabolic neuropeptide with multiple and diverse physiological functions including a key role in energy homoeostasis. Rodent studies have shown that the ablation of functional MCH results in a lean phenotype, increased energy expenditure and resistance to diet-induced obesity. These findings have generated interest among pharmaceutical companies vigilant for potential anti-obesity agents. Nutritional status affects reproductive physiology and behaviours, thereby optimising reproductive success and the ability to meet energetic demands. This complex control system entails the integration of direct or indirect peripheral stimuli with central effector systems and involves numerous mediators. A role for MCH in the reproductive axis has emerged, giving rise to the premise that MCH may serve as an integratory mediator between those discrete systems that regulate energy balance and reproductive function. Hence, this review focuses on published evidence concerning i) the role of MCH in energy homoeostasis and ii) the regulatory role of MCH in the reproductive axis. The question as to whether the MCH system mediates the integration of energy homoeostasis with the neuroendocrine reproductive axis and, if so, by what means has received limited coverage in the literature; evidence to date and current theories are summarised herein.
authors.affiliation: Department of Human and Health Sciences, School of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK and.
authors.forename: Jane
authors.initials: J
authors.lastname: Naufahu
authors.forename: Adam D
authors.initials: AD
authors.lastname: Cunliffe
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Murray
mesh_terms: D000818:Animals; D001069:Appetite Regulation; D001070:Appetitive Behavior; D003259:Consummatory Behavior; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D007028:Hypothalamic Hormones / Q000378:metabolism*; D008543:Melanins / Q000378:metabolism*; D009490:Neurosecretory Systems / Q000502:physiology; D010907:Pituitary Hormones / Q000378:metabolism*; D012098:Reproduction; D055703:Reproductive Physiological Phenomena
chemical_list: D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone