title: TDAE strategy for the synthesis of 2,3-diaryl N-tosylaziridines.
abstract: We report herein an original and rapid synthesis of 2,3-diaryl N-tosylaziridines by TDAE strategy starting from ortho- or para-nitro(dichloromethyl)benzene derivatives and N-tosylimines. A mixture of cis/trans isomers was isolated from 1-(dichloromethyl)-4-nitrobenzene, whereas only trans-aziridines were obtained from ortho-nitro derivatives.
authors.affiliation: Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire ICR, Aix-Marseille Université, UMR CNRS 7273, 27 Boulevard Jean Moulin - CS 30064, 13385 Marseille Cedex 05, France.
authors.forename: Omar
authors.initials: O
authors.lastname: Khoumeri
authors.forename: Cédric
authors.initials: C
authors.lastname: Spitz
authors.forename: Thierry
authors.initials: T
authors.lastname: Terme
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D004123:Dimethylamines / Q000138:chemical synthesis / Q000737:chemistry*; D005030:Ethylenes / Q000138:chemical synthesis / Q000737:chemistry*; D009578:Nitrobenzenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001388:Aziridines; D004123:Dimethylamines; D005030:Ethylenes; D009578:Nitrobenzenes; C036077:nitrobenzene; C548965:tetrakis(dimethylamino)ethylene