title: Variants in ZNRD1 gene predict HIV-1/AIDS disease progression in a Han Chinese population in Taiwan.
abstract: Patients demonstrate notable variations in disease progression following human immunodeficiency virus (HIV) infection. We aimed to identify ZNRD1 and RNF39 genetic variants linked to AIDS progression. We conducted a genetic association study in HIV-1-infected Han Chinese patients residing in Taiwan. The clinical characteristics of 143 HIV-1-infected patients were measured, and patients were split into 2 groups: AIDS progression and AIDS non-progression. Genotyping of ZNRD1 and RNF39 was performed in all participants. We found that patients in the AIDS progression group had higher HIV-1 viral loads and lower CD4 cell counts than did patients in the AIDS non-progression group. The frequency of the AA genotype of ZNRD1 (rs16896970) was lower in the AIDS progression group than in the AIDS non-progression group. Patients with AA genotypes had lower levels of HIV-1 viral loads and higher levels of CD4 cell counts than did patients with AG+GG genotypes. AIDS progression in patients with the AA group is significantly different from that in patients with the AG and GG groups by using Kaplan-Meier survival analysis. The hazard ratio for progression was lower in the AA group than in the AG and GG groups. We identified a SNP that contributes to AIDS progression in HIV-1-infected patients in this population. This SNP had a significant protective influence on AIDS progression, and polymorphisms of the ZNRD1 gene may play a role in the pathogenesis of HIV-1 infection.
authors.affiliation: Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Ying-Ju
authors.initials: YJ
authors.lastname: Lin
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Lan
authors.forename: Chien-Hui
authors.initials: CH
authors.lastname: Hung
authors.forename: Ting-Hsu
authors.initials: TH
authors.lastname: Lin
authors.forename: Shao-Mei
authors.initials: SM
authors.lastname: Huang
authors.forename: Chiu-Chu
authors.initials: CC
authors.lastname: Liao
authors.forename: Cheng-Wen
authors.initials: CW
authors.lastname: Lin
authors.forename: Chih-Ho
authors.initials: CH
authors.lastname: Lai
authors.forename: Ni
authors.initials: N
authors.lastname: Tien
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.forename: Mao-Wang
authors.initials: MW
authors.lastname: Ho
authors.forename: Wen-Kuei
authors.initials: WK
authors.lastname: Chien
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Jen-Hsien
authors.initials: JH
authors.lastname: Wang
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology / Q000401:mortality / Q000821:virology; D000328:Adult; D044466:Asian People / Q000235:genetics*; D018791:CD4 Lymphocyte Count; D004268:DNA-Binding Proteins / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D056726:Genetic Association Studies; D014644:Genetic Variation; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000401:mortality / Q000821:virology; D015497:HIV-1; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan; D019562:Viral Load; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D017874:Immediate-Early Proteins; C406241:POLR1H protein, human; C444639:RNF39 protein, human