title: Synthesis of azahelicene N-oxide by palladium-catalyzed direct C-H annulation of a pendant (Z)-bromovinyl side chain.
abstract: Driving benzene round the twist: Azahelicene derivatives were synthesized in high yields by utilizing palladium-catalyzed C-H annulation reactions. Functionalization at the C5 position in 6-azahelicene by using palladium-catalyzed C-H arylation also gave coupling products in good yields. A tandem intra- and intermolecular double C-H coupling reaction was performed to give a functionalized helicene in a one-pot procedure.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan), Fax: (+81) 72-254-9931.
authors.forename: Eri
authors.initials: E
authors.lastname: Kaneko
authors.forename: Yuki
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Ken
authors.initials: K
authors.lastname: Kamikawa
keywords: CH activation; azahelicenes; domino reactions; helical structures; palladium