title: [What use of progesterone to prevent preterm birth?].
abstract: Widely prescribed in the years 1970-1980 to prolong gestation, progesterone has regained interest after the publication of randomized trials since 10 years. In women at increased risk of preterm birth with a history of preterm delivery or late miscarriage, the use of progesterone, especially intramuscularly may reduce the incidence of spontaneous preterm birth. In contrast, in cases of preterm labor or twin pregnancies, progesterone efficacy to reduce preterm birth has not been demonstrated. In women with asymptomatic midtrimester sonographic short cervix, randomized studies show conflicting results and new studies are necessary before its widespread utilisation.
authors.affiliation: Service de gynécologie-obstétrique, université Paris-Diderot, hôpital Louis-Mourier, Colombes, France. helenelegardeur@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Legardeur
authors.forename: L
authors.initials: L
authors.lastname: Mandelbrot
authors.forename: G
authors.initials: G
authors.lastname: Kayem
mesh_terms: D002584:Cervix Uteri / Q000000981:diagnostic imaging; D005260:Female; D005865:Gestational Age; D006801:Humans; D007752:Obstetric Labor, Premature / Q000503:physiopathology / Q000517:prevention & control; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D059285:Pregnancy, Twin; D047928:Premature Birth / Q000517:prevention & control*; D011374:Progesterone / Q000008:administration & dosage* / Q000627:therapeutic use; D014427:Twins; D014463:Ultrasonography; D002581:Uterine Cervical Incompetence / Q000503:physiopathology
chemical_list: D011374:Progesterone
keywords: Antécédent d’accouchement prématuré; Col court; Grossesse gémellaire; Menace d’accouchement prématuré; Preterm delivery history; Preterm labor; Progesterone; Progestérone; Short cervix; Twin pregnancy