title: Interactions between human immunodeficiency virus type 1 and polymorphonuclear neutrophils.
abstract: Polymorphonuclear neutrophils (PMN) are the most abundant circulating leukocytes. They represent a first line of innate immunity against a large panel of microbial pathogens, pending development of specific immune responses. The role of PMN in human immunodeficiency virus type 1 (HIV-1) disease has mainly been investigated from the point of view of the increased susceptibility of HIV-1-infected patients to bacterial and fungal infections. However, it is now clear that the relationship between PMN and HIV-1 is far more complex. This review examines both the beneficial and the detrimental effects of PMN during HIV infection.
authors.affiliation: Université Pierre et Marie Curie-Paris 6, INSERM UMR-S 945, Immunité et Infection, Hôpital Pitié Salpêtrière, Paris, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Casulli
authors.forename: Carole
authors.initials: C
authors.lastname: Elbim
mesh_terms: D000818:Animals; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D009504:Neutrophils / Q000276:immunology*