title: [A case of necrotizing fasciitis developed in a patient with recurrent rectal cancer treated with chemotherapy].
abstract: A fifty-two-year-old female with advanced rectal cancer underwent low anterior resection and hysterectomy. After local pelvic recurrence, she underwent radiation therapy(50 Gy in total), and then chemotherapy(XELOX+bevacizumab)was started. However, left femoral pain developed after the second course of chemotherapy, and necrotizing fasciitis associated with lower bowel perforation was found. Although bowel perforation is known as a serious side-effect of bevacizumab, its association with fasciitis is rare.
authors.affiliation: Dept. of Surgery, Kawasaki Municipal Ida Hospital, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Shimada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Ishii
authors.forename: Naokazu
authors.initials: N
authors.lastname: Chiba
authors.forename: Shuji
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Arisawa
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Hashimoto
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D000068258:Bevacizumab; D000069287:Capecitabine; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D019115:Fasciitis, Necrotizing / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008875:Middle Aged; D010071:Oxaloacetates; D012004:Rectal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012008:Recurrence
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D010071:Oxaloacetates; D003841:Deoxycytidine; D000068258:Bevacizumab; D000069287:Capecitabine; D005472:Fluorouracil