title: GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects.
abstract: Published data on the association between the GST genes polymorphisms and male infertility risk are inconclusive. We investigated GST genes polymorphisms in a large sample size case-control study, and conducted a literature-based meta-analysis of 6934 individuals. Our case-control study showed the GSTM1 null genotype was significantly associated with idiopathic oligozoospermia, while the null genotype of GSTT1 was significantly associated with normozoospermia and azoospermia. Additionally, significantly elevated GSTT1 expression levels were observed in present genotype compared with null genotype. In the meta-analysis, the null genotype of GSTM1 was associated with a significantly increased risk of male infertility. Furthermore, a stratification analysis showed that the risk of GSTM1 polymorphism was associated with male infertility in both Asian and Caucasian groups. Further studies of GSTM1 and GSTT1 with their biological functions are needed to understand the role of these genes in the development of male infertility.
authors.affiliation: State Key Laboratory of Reproductive Medicine, Wuxi Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China. wwu@njmu.edu.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Qiuqin
authors.initials: Q
authors.lastname: Tang
authors.forename: Simin
authors.initials: S
authors.lastname: Zhang
authors.forename: Beilei
authors.initials: B
authors.lastname: Yuan
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.lastname: Di Wu
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.forename: Chuncheng
authors.initials: C
authors.lastname: Lu
authors.forename: Yankai
authors.initials: Y
authors.lastname: Xia
authors.forename: Daozhen
authors.initials: D
authors.lastname: Chen
authors.forename: Jiahao
authors.initials: J
authors.lastname: Sha
authors.forename: Xinru
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000097:blood / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1