title: The presence and distribution of alpha adrenergic receptors in human renal pelvis and calyces.
abstract: In this study, we aimed to demonstrate the presence of Alpha (α) 1 receptors and subtypes in human pelvis and calyces, because an agent to facilitate kidney stone movement and help decrease pain may be an α 1 adrenergic blocker, as used in ureteral stones. Twenty patients who applied to our clinic for renal cell carcinoma were enrolled to the study. All patients underwent radical nephrectomy. After the specimens were removed, excisional biopsies were performed on healthy pelvises and calyces. Mean α-receptor stain rates in renal pelvis were 2.65 ± 0.74, 1.35 ± 0.81 and 2.9 ± 0.30 for α 1A, 1B and 1D, respectively. For calyces, the rates are 2.40 ± 0.82, 1.50 ± 0.76 and 2.75 ± 0.44 for α 1A, 1B and 1D, respectively (Fig. 1). When the staining patterns were compared, α 1A and 1D were expressed more in both pelvis and calyces than α 1B (p < 0.05). After the demonstration of α-adrenergic receptors in pelvis and calyces of human kidney, it may be helpful in coming up with new alternative treatments for patients suffering from kidney stones.
authors.affiliation: Department of Urology, Ministry of Health, Ankara Dışkapı Yıldırım Beyazit Teaching and Research Hospital, Ankara, Turkey.
authors.forename: Osman Raif
authors.initials: OR
authors.lastname: Karabacak
authors.forename: Demet
authors.initials: D
authors.lastname: Yilmazer
authors.forename: Ufuk
authors.initials: U
authors.lastname: Ozturk
authors.forename: Nevzat Can
authors.initials: NC
authors.lastname: Sener
authors.forename: Hakan
authors.initials: H
authors.lastname: Saltas
authors.forename: Yurdum
authors.initials: Y
authors.lastname: Karabacak
authors.forename: Murat
authors.initials: M
authors.lastname: Alper
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D007669:Kidney Calculi / Q000188:drug therapy / Q000378:metabolism; D007670:Kidney Calices / Q000033:anatomy & histology / Q000378:metabolism*; D007682:Kidney Pelvis / Q000033:anatomy & histology / Q000378:metabolism*; D018340:Receptors, Adrenergic, alpha-1 / Q000145:classification / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D018340:Receptors, Adrenergic, alpha-1