title: Modest efficacy of voriconazole against murine infections by Sporothrix schenckii and lack of efficacy against Sporothrix brasiliensis.
abstract: The efficacy of voriconazole (VRC) was evaluated against two strains of each of the two most common species causing sporotrichosis, Sporothrix schenckii sensu stricto and Sporothrix brasiliensis, using a murine model of disseminated infection. Voriconazole was administered at doses of 20 or 40 mg kg(-1) per day by gavage. The drug showed some efficacy, especially at 40 mg kg(-1) per day, in prolonging the survival and reducing fungal load in spleen and liver in mice infected with S. schenckii, whereas in animals infected with S. brasiliensis the drug did not work.
authors.affiliation: Unitat d'Anatomia Patológica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Fernández-Silva
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D013154:Spleen / Q000382:microbiology; D013175:Sporothrix / Q000187:drug effects*; D013174:Sporotrichosis / Q000188:drug therapy*; D016019:Survival Analysis; D016896:Treatment Outcome; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole
keywords: Voriconazole; animal model; sporotrichosis