title: Risk factors associated with sensitization to hydroxyisohexyl 3-cyclohexene carboxaldehyde.
abstract: BACKGROUND
  Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) is a synthetic fragrance chemical and an important contact allergen, at least in Europe. Despite this importance, little is known about risk factors associated with this allergen.
  
  
  OBJECTIVE
  To examine factors from the history and clinical presentation of patch tested patients associated with HICC sensitization.
  
  
  METHODS
  Contact allergy surveillance data of 95 637 patients collected by the Information Network of Departments of Dermatology (IVDK, www.ivkd.org) in 2002-2011 were analysed. Point and interval estimates of the relative risk were derived from multifactorial logistic regression modelling.
  
  
  RESULTS
  The overall prevalence of HICC sensitization was 2.24%. The strongest risk factors were polysensitization and dermatitis of the axillae, followed by dermatitis at other sites. No consistent and significant time trend was observed in this analysis. As compared with the youngest patients, the odds of HICC sensitization increased approximately three-fold in the 52-67-year age group, and strongly declined with further increasing age.
  
  
  CONCLUSIONS
  The risk pattern with regard to age and affected anatomical site differed from that observed with other fragrance screening allergens. Cosmetic exposure, as broadly defined here, was a stronger and more prevalent individual risk factor than occupational exposure.
authors.affiliation: Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, Erlangen, D-91054, Germany. wolfgang.uter@imbe.med.uni-erlangen.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Uter
authors.forename: Johannes
authors.initials: J
authors.lastname: Geier
authors.forename: Axel
authors.initials: A
authors.lastname: Schnuch
authors.forename: Olaf
authors.initials: O
authors.lastname: Gefeller
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000447:Aldehydes / Q000009:adverse effects*; D053138:Cyclohexenes / Q000009:adverse effects*; D016208:Databases, Factual; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology; D003876:Dermatitis, Atopic / Q000453:epidemiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects*; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution
chemical_list: D000447:Aldehydes; D053138:Cyclohexenes; D010476:Perfume; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde
keywords: CAS 31906-04-4; CAS 51414-25-6; contact allergy; hydroxyisohexyl 3-cyclohexene carboxaldehyde; risk factors