title: Therapeutic potential of GABA(B) receptor ligands in drug addiction, anxiety, depression and other CNS disorders.
abstract: Glutamate and γ-aminobutyric acid (GABA) are the major excitatory and inhibitory neurotransmitter systems, respectively in the central nervous system (CNS). Dysregulation, in any of these or both, has been implicated in various CNS disorders. GABA acts via ionotropic (GABA(A) and GABA(C) receptor) and metabotropic (GABA(B)) receptor. Dysregulation of GABAergic signaling and alteration in GABA(B) receptor expression has been implicated in various CNS disorders. Clinically, baclofen-a GABA(B) receptor agonist is available for the treatment of spasticity, dystonia etc., associated with various neurological disorders. Moreover, GABAB receptor ligands has also been suggested to be beneficial in various neuropsychiatric and neurodegenerative disorders. The present review is aimed to discuss the role of GABA(B) receptors and the possible outcomes of GABA(B) receptor modulation in CNS disorders.
authors.affiliation: Neuropharmacology Division, Department of Pharmacology, I.S.F. College of Pharmacy, Moga 142001, Punjab, India.
authors.forename: Kushal
authors.initials: K
authors.lastname: Kumar
authors.forename: Sorabh
authors.initials: S
authors.lastname: Sharma
authors.forename: Puneet
authors.initials: P
authors.lastname: Kumar
authors.forename: Rahul
authors.initials: R
authors.lastname: Deshmukh
mesh_terms: D001007:Anxiety / Q000378:metabolism / Q000628:therapy*; D002493:Central Nervous System Diseases / Q000378:metabolism / Q000628:therapy*; D003863:Depression / Q000378:metabolism / Q000628:therapy*; D018757:GABA Modulators / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008024:Ligands; D011487:Protein Conformation; D018080:Receptors, GABA-B / Q000737:chemistry / Q000378:metabolism*; D019966:Substance-Related Disorders / Q000378:metabolism / Q000628:therapy*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D018757:GABA Modulators; D008024:Ligands; D018080:Receptors, GABA-B; D005680:gamma-Aminobutyric Acid
keywords: Addiction; Anxiety; CNS disorders; Depression; GABA; Neurodegenerative disorders