title: The regulation and function of the NUAK family.
abstract: AMP-activated protein kinase (AMPK) is a critical regulator of cellular and whole-body energy homeostasis. Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently. These kinases show a similar structural organization, including an N-terminal catalytic domain, followed by a ubiquitin-associated domain and a C-terminal spacer sequence, which in some cases also contains a kinase-associated domain 1. Eleven of the ARKs are phosphorylated and activated by the master upstream kinase liver kinase B1. However, most of these ARKs are largely unknown, and the NUAK family seems to have different regulations and functions. This review contains a brief discussion of the NUAK family including the specific characteristics of NUAK1 and NUAK2.
authors.affiliation: Department of Endocrinology Central Laboratory, Provincial Hospital affiliated to Shandong University, Jinan, China Department of Endocrinology and Metabolism, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan Department of Dentistry, School of Dentistry, Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan Department of Education and Research, Taipei City Hospital, Taipei, Taiwan.
authors.forename: Xianglan
authors.initials: X
authors.lastname: Sun
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.forename: Hung-Yu
authors.initials: HY
authors.lastname: Chien
authors.forename: Wan-Chun
authors.initials: WC
authors.lastname: Li
authors.forename: Jiajun
authors.initials: J
authors.lastname: Zhao
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases
keywords: AMP-activated protein kinase (AMPK); AMPK-related kinase; ARK5; LKB1; NUAK family; sucrose-non-fermenting protein kinase (SNF1)/AMPK-related kinase (SNARK)