title: Effect of MTA-based sealer on the healing of periapical lesions.
abstract: Some manufacturers have recently added specific components to improve the ease of handling and insertion material properties of MTA in order to create MTA-based sealers.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the healing of periapical lesions in canine teeth after a single session of endodontic treatment with MTA Fillapex® compared with Sealapex® or Endo-CPM-Sealer®.
  
  
  METHODS
  Sixty-two root canals were performed on two 1-year-old male dogs. After coronal access and pulp extirpation, the canals were exposed to the oral cavity for 6 months in order to induce periapical lesions. The root canals were prepared, irrigated with a solution of 2.5% sodium hypochlorite and filled with gutta-percha and different sealers, according to the following groups: 1) Sealapex®; 2) Endo-CPM-Sealer®; and 3) MTA Fillapex®. Some teeth with periapical lesions were left untreated for use as positive controls. Healthy teeth were used as negative controls. After 6 months, the animals were sacrificed and serial sections from the roots were prepared for histomorphologic analysis and stained with hematoxylin and eosin and the Brown and Brenn technique. The lesions were scored according to pre-established histomorphologic parameters and the scores statistically analyzed using the Kruskal-Wallis test.
  
  
  RESULTS
  All 3 materials produced similar patterns of healing (p>0.05); in particular, persistent inflammation and absence of complete periapical tissue healing were consistently noted.
  
  
  CONCLUSIONS
  Preparation of the infected root canals followed by filling with the materials studied was insufficient to provide complete healing of the periapical tissues.
authors.affiliation: Department of Endodontics, Araçatuba School of Dentistry, Univ. Estadual Paulista, Araçatuba, SP, Brazil. joao@foa.unesp.br
authors.forename: João Eduardo
authors.initials: JE
authors.lastname: Gomes-Filho
authors.forename: Simone
authors.initials: S
authors.lastname: Watanabe
authors.forename: Luciano Tavares Angelo
authors.initials: LT
authors.lastname: Cintra
authors.forename: Mauro Juvenal
authors.initials: MJ
authors.lastname: Nery
authors.forename: Eloi
authors.initials: E
authors.lastname: Dezan-Júnior
authors.forename: India Olinta Azevedo
authors.initials: IO
authors.lastname: Queiroz
authors.forename: Carolina Simonetti
authors.initials: CS
authors.lastname: Lodi
authors.forename: Maria Daniela
authors.initials: MD
authors.lastname: Basso
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use*; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D017610:Calcium Compounds / Q000627:therapeutic use*; D002126:Calcium Hydroxide / Q000627:therapeutic use*; D003786:Dental Pulp Cavity / Q000187:drug effects / Q000382:microbiology; D004285:Dogs; D004338:Drug Combinations; D008297:Male; D008422:Materials Testing; D010087:Oxides / Q000627:therapeutic use*; D010486:Periapical Tissue / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D015203:Reproducibility of Results; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D012388:Root Canal Irrigants / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000379:methods*; D012459:Salicylates / Q000627:therapeutic use*; D017640:Silicates / Q000627:therapeutic use*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D017607:Aluminum Compounds; D000890:Anti-Infective Agents; D017610:Calcium Compounds; D004338:Drug Combinations; C540763:Endo-CPM-Sealer; D010087:Oxides; D012387:Root Canal Filling Materials; D012388:Root Canal Irrigants; D012459:Salicylates; D017640:Silicates; C086631:mineral trioxide aggregate; C055601:Sealapex; D002126:Calcium Hydroxide