title: [Association between interleukin-1B polymorphisms and chronic obstructive pulmonary disease: a meta-analysis].
abstract: OBJECTIVE
  To explore the association between the -511C/T, -31T/C and +3954C/T polymorphisms of interleukin-1B (IL-1B) gene and chronic obstructive pulmonary disease (COPD) using the method of meta-analysis.
  
  
  METHODS
  Comprehensive searches were performed of PubMed, Embase, Ovid, Wanfang and Chinese journal full-text database to retrieve the related case-control studies. The pooled odds ratios were performed respectively for allele comparison, additive genetic model, dominant genetic model and recessive genetic model and subgroup analysis was also performed by ethnicity.
  
  
  RESULTS
  Seven case-control studies were included for meta-analysis. Pooled analysis showed that neither -511C/T, -31T/C nor +3954 C/T polymorphisms increased the susceptibility to COPD. In the subgroup analysis by ethnicity, significant risks were found in the Caucasian population for -511C/T T allele (OR = 1.76, 95%CI 1.22 - 2.54, P = 0.002), but not in the Asian population (OR = 0.94, 95%CI 0.64 - 1.38, P = 0.736). Significant risks were also found in the Caucasian population for -31T/C C allele (OR = 0.62, 95%CI 0.40 - 0.97, P = 0.035), but not in the Asian population (OR = 1.06, 95%CI 0.89 - 1.26, P = 0.533).
  
  
  CONCLUSIONS
  IL-1B polymorphisms may play a role in the susceptibility of COPD in an ethnicity-specific manner. In the Caucasian population, the risk of COPD was associated positively with the IL-1B -511C/T T allele and negatively with the IL-1B -31T/C C allele.
authors.affiliation: Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Mei
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.forename: Ning
authors.initials: N
authors.lastname: Shen
authors.forename: Bei
authors.initials: B
authors.lastname: He
mesh_terms: D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*
chemical_list: D053583:Interleukin-1beta