title: Atypical cadherin negotiates a turn.
abstract: Planar cell polarity (PCP) signaling is involved in many polarized cell behaviors. In this issue of Developmental Cell, Tatin et al. (2013) show that the atypical cadherin Celsr1 is transiently localized to cellular protrusions in lymphatic endothelial cells and acts to orient valve-forming cells perpendicular to the vessel axis.
authors.affiliation: Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Dongbo
authors.initials: D
authors.lastname: Shi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Fujimori
authors.forename: Tadashi
authors.initials: T
authors.lastname: Uemura
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism*; D000818:Animals; D016764:Cell Polarity; D005260:Female; D006801:Humans; D042601:Lymphatic Vessels / Q000378:metabolism*; D009024:Morphogenesis; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: C117380:Celsr1 protein, mouse; D043562:Receptors, G-Protein-Coupled