title: [The influence of amlodipine on transcapillary metabolism of oxygen during coronary heart disease with insulin resistance].
abstract: This three-week open uncontrolled study included 34 men (mean age 53.14+-1.19 yr) with coronary heart disease (CHD) and insulin resistance (HOMA >2. 77); it was designed to estimate effect of amlodipine on transcapillary oxygen metabolism (TCOM). Multivascular stenosing coronary atherosclerosis was managed by aortocoronary bypass surgery. Traditional methods applied in specialized cardiological clinics were supplemented by TCOM measurement using a PA-2 polarograph (Czech Rep.). Polarography revealed deterioration of TCOM parameters including permeability of hemocapillaries, adaptive reserves of the microcirculatory bed, and oxygen supply to the tissues. Amlodipine therapy demonstrated high antianginal potency of this drug and its ability to improve TCOM
authors.forename: A E
authors.initials: AE
authors.lastname: Tepliakov
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Pushnikova
authors.forename: V V
authors.initials: VV
authors.lastname: Kaliuzhin
authors.forename: I D
authors.initials: ID
authors.lastname: Bespalova
authors.forename: E V
authors.initials: EV
authors.lastname: Kaliuzhina
authors.forename: M I
authors.initials: MI
authors.lastname: Kaliuzhina
mesh_terms: D017311:Amlodipine / Q000008:administration & dosage* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D017311:Amlodipine; D010100:Oxygen