title: XRCC1 polymorphisms and differentiated thyroid carcinoma risk: a meta-analysis.
abstract: The objective of this study is to quantitatively derive a more precise estimation of the association between X-ray repair cross-complementing group 1 (XRCC1) gene polymorphisms and differentiated thyroid carcinoma risk. A comprehensive literature search of three databases was conducted. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated with fixed-effect models and random-effect models when appropriate. Overall, no association of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms with differentiated thyroid carcinoma risk was found. In subgroup analyses, a decreased differentiated thyroid carcinoma risk was observed among Caucasians (Gln vs. Arg, OR=0.86, 95% CI=0.77-0.96, P=0.343 for heterogeneity; Gln/Arg vs. Arg/Arg, OR=0.84, 95% CI=0.71-0.98, P=0.229 for heterogeneity; Gln/Gln vs. Arg/Arg, OR=0.77, 95% CI=0.60-0.99, P=0.477 for heterogeneity; dominant genetic model, OR=0.82, 95% CI=0.71-0.95, P=0.272 for heterogeneity), not among Asians. No publication bias was observed. Our results suggest that XRCC1 Arg399Gln polymorphism is not associated with differentiated thyroid carcinoma risk, while a decreased risk is observed among Caucasian population.
authors.affiliation: School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hu
authors.forename: Xueying
authors.initials: X
authors.lastname: Hu
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Long
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.forename: Bo
authors.initials: B
authors.lastname: Wei
mesh_terms: D019943:Amino Acid Substitution; D044466:Asian People; D002277:Carcinoma / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000208:ethnology / Q000235:genetics*; D044465:White People; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human
keywords: BER; CI; Differentiated thyroid carcinoma; HWE; Hardy–Weinberg equilibrium; Meta-analysis; OR; Polymorphisms; SNP; X-ray repair cross-complementing group 1; XRCC1; base excision repair; confidence interval; odds ratio; single nucleotide polymorphism