title: Human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Hangzhou, China.
abstract: BACKGROUND
  To investigate the infection status and predominant genotype distribution of human papillomavirus (HPV) infection among Chinese patients with mucopurulent cervicitis (MPC) or cervical cancer (CC) in Hangzhou.
  
  
  METHODS
  Initially, 217 cases of healthy cervix controls (n=50), acute MPC (n=89), and CC (n=78) were included; samples were collected between January 1, 2010, and January 30, 2013. Cervical specimens were screened for HPV using a nested polymerase chain reaction assay and DNA sequencing.
  
  
  RESULTS
  Overall prevalence of HPV infection was 16.7% in the control group, 51.9% in the MPC group, and 84.4% in the CC group. The predominant genotype detected in all 3 groups was the oncogenic variant HPV 16 (55.8%, 17.3%, and 6.3% in the CC, MPC and control specimens, respectively), HPV58 was the second most predominant HPV type in CC (9.1%), MPC (8.6%), and control group (4.2%). Most or all of the genotypes were oncogenic in the three groups.
  
  
  CONCLUSIONS
  Infection with HPV was found to be prevalent among Chinese women with MPC or CC and oncogenic variants were in the majority. Therefore, peoples who suffered MPC with HPV DNA positive should be regularly followed-up, for prevention and early treatment of cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Chinese Medicine Hospital of Hangzhou, Hangzhou, China. shenxinghang@126.com
authors.forename: Xing-Hang
authors.initials: XH
authors.lastname: Shen
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000473:pathology; D002681:China; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications* / Q000235:genetics / Q000821:virology; D016133:Polymerase Chain Reaction; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000473:pathology; D002575:Uterine Cervicitis / Q000209:etiology* / Q000473:pathology; D055815:Young Adult
chemical_list: D004279:DNA, Viral