title: Xanthine oxidase inhibition for hyperuricemic heart failure patients: design and rationale of the EXACT-HF study.
authors.affiliation: Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. mgivertz@partners.org
authors.forename: Michael M
authors.initials: MM
authors.lastname: Givertz
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Mann
authors.forename: Kerry L
authors.initials: KL
authors.lastname: Lee
authors.forename: Jenny C
authors.initials: JC
authors.lastname: Ibarra
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Velazquez
authors.forename: Adrian F
authors.initials: AF
authors.lastname: Hernandez
authors.forename: Alice M
authors.initials: AM
authors.lastname: Mascette
authors.forename: Eugene
authors.initials: E
authors.lastname: Braunwald
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000503:physiopathology; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000188:drug therapy*; D018384:Oxidative Stress / Q000502:physiology; D018579:Patient Selection; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D017382:Reactive Oxygen Species / Q000378:metabolism; D012107:Research Design; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D000493:Allopurinol; D014969:Xanthine Oxidase
keywords: allopurinol; clinical trial; heart failure; xanthine oxidase