title: Group B streptococcal meningitis in infants beyond the neonatal period.
abstract: OBJECTIVE
  To describe the clinico-bacteriological profile, and early outcomes of infants diagnosed with Group B streptococcus (GBS) meningitis.
  
  
  METHODS
  This was a retrospective review of infants (aged 1 mo to 2 y) diagnosed with GBS meningitis in a tertiary care hospital in New Delhi from October 2010 through January 2012. The clinico-bacteriological data and early outcomes of infants with suspected bacterial meningitis and a positive CSF latex agglutination test for GBS were studied. The CSF samples were subjected to PCR for broad spectrum 16s ribosomal DNA and the GBS species specific gene, the scpB.
  
  
  RESULTS
  Twenty seven patients (13 boys, and 14 girls) were diagnosed with GBS meningitis during the study period. Broad spectrum 16s ribosomal DNA PCR was performed on 18 of the 27 CSF samples. Sixteen were positive. All these 16 were also positive for the species specific scpB gene. The median duration of hospital stay was 7 d (range 1-72 d). Nine patients died. One patient each developed ventriculitis, optic atrophy and hydrocephalus. Overall, 12 patients had a complete recovery at discharge.
  
  
  CONCLUSIONS
  GBS must be considered in the etiology of bacterial meningitis in Indian infants.
authors.affiliation: Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Shalini
authors.initials: S
authors.lastname: Dwivedi
authors.forename: Bimal K
authors.initials: BK
authors.lastname: Das
authors.forename: Satinder
authors.initials: S
authors.lastname: Aneja
authors.forename: Suvasini
authors.initials: S
authors.lastname: Sharma
authors.forename: Mona K
authors.initials: MK
authors.lastname: Chaturvedi
authors.forename: Geoff
authors.initials: G
authors.lastname: Kahn
authors.forename: Sean P
authors.initials: SP
authors.lastname: Fitzwater
authors.forename: Aruna
authors.initials: A
authors.lastname: Chandran
authors.forename: Nitya
authors.initials: N
authors.lastname: Wadhwa
authors.forename: Shinjini
authors.initials: S
authors.lastname: Bhatnagar
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000382:microbiology; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000175:diagnosis / Q000382:microbiology; D013292:Streptococcus agalactiae