title: A comparison of extracellular excitatory amino acids release inhibition of acute lamotrigine and topiramate treatment in the hippocampus of PTZ-kindled epileptic rats.
abstract: In this communication, the effect of acute treatment with lamotrigine (LTG) and topiramate (TPM) was investigated on release of the main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-kindled freely moving rats using microdialysis. The results showed that the level of Glu and Asp significantly decreased in the PTZ-kindled epileptic (EP) rat hippocampus after the 20 mg/kg LTG or 40 mg/kg TPM administration. But LTG gave rise to a better result than TPM in controlling EAA release.
authors.affiliation: State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China. dy_dengyan@yahoo.com.cn
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.forename: Minghuan
authors.initials: M
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.forename: Zhijiang
authors.initials: Z
authors.lastname: Xi
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Li
authors.forename: Nongyue
authors.initials: N
authors.lastname: He
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000737:chemistry; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D018683:Excitatory Amino Acid Agents / Q000378:metabolism*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000737:chemistry; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D000077213:Lamotrigine; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077236:Topiramate; D016896:Treatment Outcome; D014227:Triazines / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000927:Anticonvulsants; D018683:Excitatory Amino Acid Agents; D018691:Excitatory Amino Acid Antagonists; D014227:Triazines; D000077236:Topiramate; D005632:Fructose; D000077213:Lamotrigine; D010433:Pentylenetetrazole