title: Green polymer chemistry VIII: synthesis of halo-ester-functionalized poly(ethylene glycol)s via enzymatic catalysis.
abstract: Halo-ester-functionalized poly(ethylene glycol)s (PEGs) are successfully prepared by the transesterification of alkyl halo-esters with PEGs using Candida antarctica lipase B (CALB) as a biocatalyst under the solventless conditions. Transesterifications of chlorine, bromine, and iodine esters with tetraethylene glycol monobenzyl ether (BzTEG) are quantitative in less than 2.5 h. The transesterification of halo-esters with PEGs are complete in 4 h. (1) H and (13) C NMR spectroscopy with MALDI-ToF and ESI mass spectrometry confirm the structure and purity of the products. This method provides a convenient and "green" process to effectively produce halo-ester PEGs.
authors.affiliation: Department of Polymer Science, The University of Akron, Akron, OH 44325, USA.
authors.forename: Marcela
authors.initials: M
authors.lastname: Castano
authors.forename: Kwang Su
authors.initials: KS
authors.lastname: Seo
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Kim
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Becker
authors.forename: Judit E
authors.initials: JE
authors.lastname: Puskas
mesh_terms: D002175:Candida / Q000201:enzymology*; D005656:Fungal Proteins / Q000737:chemistry*; D008049:Lipase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005656:Fungal Proteins; D011092:Polyethylene Glycols; D008049:Lipase; C431349:lipase B, Candida antarctica
keywords: enzymes; functionalization of polymers; green polymer chemistry; halo-esters; solventless conditions