title: [Usefulness of bevacizumab with paclitaxel for advanced breast cancer - a case report].
abstract: A 55-year-old woman with an exudative, necrotizing left breast tumor consulted Ibaraki Prefectural Central Hospital and Cancer Center. We diagnosed her as advanced ER+, PgR-, HER2- invasive ductal carcinoma of the left breast by tumor needle biopsy. FDG-PET/CT revealed multiple lymph node, pulmonary, bone, and hepatic metastases. Systemic chemotherapy with biweekly bevacizumab and weekly paclitaxel(PTX)was administered. The chemotherapy induced a widespread tumor lysis in her left chest wall. We continued chemotherapy, and the ulcer has been healing gradually. We recognized that bevacizumab with PTX successfully brought about a rapid, good local response, and improved the patient's quality of life.
authors.affiliation: Dept. of Medical Oncology, Ibaraki Prefectural Central Hospital and Cancer Center, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Morishita
authors.forename: Shoichi
authors.initials: S
authors.lastname: Mitsuhashi
authors.forename: Fumie
authors.initials: F
authors.lastname: Fujisawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Hirano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kojima
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D017239:Paclitaxel