title: The functional role of the frontal cortex in pre-attentive auditory change detection.
abstract: Accounts of the functional role of the frontal cortex in pre-attentive auditory change detection include attention switching, response inhibition, contrast enhancement, and activation of a predictive model. These accounts assume different sequential activation patterns between the temporal and frontal cortices: Change detection in the auditory areas of the superior temporal cortex (STC) followed by inferior frontal cortex (IFC) activation for attention switching and response inhibition; STC preceded by IFC activation for contrast enhancement; and an IFC-STC-IFC activation sequence for the predictive model. We used the event-related optical signal (EROS), which provides a temporal resolution of milliseconds and a spatial resolution of 5 to 10mm, combined with lagged correlation path modeling to examine the response of the right frontal and temporal cortices to auditory duration deviants of varying magnitude. Event-related potentials (ERPs) were also recorded, as was the slow optical (hemodynamic) brain response. The data analyses revealed temporal-frontal, frontal-temporal-frontal, and temporal-frontal activation patterns when the deviants represented relatively large, medium, and small changes from the standard stimulus, respectively. These results indicate that the degree of deviance modulates spatio-temporal dynamics within the STC-IFC auditory change detection network.
authors.affiliation: Temasek Laboratories, National University of Singapore, Singapore.
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Tse
authors.forename: Teemu
authors.initials: T
authors.lastname: Rinne
authors.forename: Kwun Kei
authors.initials: KK
authors.lastname: Ng
authors.forename: Trevor B
authors.initials: TB
authors.lastname: Penney
mesh_terms: D001288:Attention / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D055815:Young Adult
keywords: Change detection; Frontal; MMN; Optical imaging; Structural equation model; Temporal