title: A new role for an old player: steroid receptor RNA Activator (SRA) represses hormone inducible genes.
abstract: In breast cancer cells the Steroid Receptor ¬RNA Activator (SRA) acts as scaffold of a complex containing HP1γ, LSD1, HDAC1/2 and CoREST, which contributes to repression of key hormone-inducible genes that must be kept silent in the absence of hormone.
authors.forename: Miguel
authors.initials: M
authors.lastname: Beato
authors.forename: Guillermo P
authors.initials: GP
authors.lastname: Vicent
mesh_terms: D000818:Animals; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D056970:Co-Repressor Proteins / Q000378:metabolism; D056284:Histone Deacetylase 1 / Q000378:metabolism; D056464:Histone Deacetylase 2 / Q000378:metabolism; D056466:Histone Demethylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006728:Hormones / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D056970:Co-Repressor Proteins; D006657:Histones; D006728:Hormones; D009419:Nerve Tissue Proteins; C121019:RCOR1 protein, human; D062085:RNA, Long Noncoding; C405423:steroid receptor RNA activator; D000090266:Chromobox Protein Homolog 5; D056466:Histone Demethylases; C495195:KDM1A protein, human; D056284:Histone Deacetylase 1; D056464:Histone Deacetylase 2