title: First synthesis of a stable isotope of Ochratoxin A metabolite for a reliable detoxification monitoring.
abstract: Due to its toxicity and presence in numerous food products, Ochratoxin A (OTA) has drawn attention for decades. This article summarizes the first synthesis of a labeled analogue of Ochratoxin α (OTα), one of the main products generated by the metabolization of OTA by microorganisms. This synthesis also led to a new labeled analogue of OTA with the deuteration located on the dihydroisocoumarin moiety allowing thus both the accurate quantification of OTA and OTα and the establishing of a reliable detoxification rate.
authors.affiliation: IBMM, UMR-CNRS-5247, Universités Montpellier I and II, Place Eugène Bataillon, 34095 Montpellier, Cedex 5, France.
authors.forename: Anaïs
authors.initials: A
authors.lastname: Bouisseau
authors.forename: Aurélie
authors.initials: A
authors.lastname: Roland
authors.forename: Florence
authors.initials: F
authors.lastname: Reillon
authors.forename: Rémi
authors.initials: R
authors.lastname: Schneider
authors.forename: Florine
authors.initials: F
authors.lastname: Cavelier
mesh_terms: D005506:Food Contamination / Q000032:analysis*; D008658:Inactivation, Metabolic; D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D009183:Mycotoxins / Q000378:metabolism* / Q000633:toxicity; D009793:Ochratoxins / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity
chemical_list: D049934:Isocoumarins; D009183:Mycotoxins; D009793:Ochratoxins; C000426:5-chloro-8-hydroxy-3,4-dihydro-3-methylisocoumarin-7-carboxylic acid; C025589:ochratoxin A