title: Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage.
abstract: Peptic ulcer disease is a gastrointestinal disorder defined by mucosal damage and free oxygen radicals associated with peptic ulcer and gastritis. Cinnamon is a traditional herb used for many diseases and it has also effects as an antioxidant, anti-inflammatory, antispasmodic and anti-ulcerative. Our research is based on oxidative stress and effects of Oleum cinnamomi on stomach, liver and kidney disorders induced by ethanol. In our experiment, 2-3 month old male Sprague-Dawley rats were used. One hour before the mucosal damage induced by 70 % ethanol, O. cinnamomi (2.5 ml/kg) was added into the groups. Gastric pH, analysis of gastric mucus and ulcer index were calculated from samples obtained from the stomach. Superoxide dismutase (SOD), malondialdehyde and catalase (CAT) levels were determined in stomach, liver and kidney homogenates and erythrocyte hemolysate. Histopathological examination of stomach, liver and kidney were determined with H&E staining. The non-treated ulcerative group showed higher scores than the control group which was treated with O. cinnamomi, when ulcer scores, gastric mucus and pH level of stomach are compared. Increased lipid peroxidation levels were observed in the liver, kidney and erythrocyte hemolysate. SOD activity was decreased in liver whereas increased in stomach of ethanol treated ulcerative groups. CAT levels were increased in stomach and liver of ethanol treated rats. Histopathological findings showed that ethanol treatment cause multiply organ damage such as stomach, liver and kidney injury. O. cinnamomi treatment protected these tissues from ethanol-induced damage. Consequently, the current investigation shows that O. cinnamomi has protective effects on ethanol-induced oxidative and mucosal damage.
authors.affiliation: Department of Medical Biology, Medical Faculty, Eskisehir Osmangazi University, 26480, Eskisehir, Turkey, c.ozbayer@gmail.com.
authors.forename: Cansu
authors.initials: C
authors.lastname: Ozbayer
authors.forename: Hulyam
authors.initials: H
authors.lastname: Kurt
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ozdemir
authors.forename: Tunc
authors.initials: T
authors.lastname: Tuncel
authors.forename: Selva
authors.initials: S
authors.lastname: Moheb Saadat
authors.forename: Dilek
authors.initials: D
authors.lastname: Burukoglu
authors.forename: Hakan
authors.initials: H
authors.lastname: Senturk
authors.forename: Irfan
authors.initials: I
authors.lastname: Degirmenci
authors.forename: Hasan Veysi
authors.initials: HV
authors.lastname: Gunes