title: Ghrelin receptors in non-Mammalian vertebrates.
abstract: The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered 3 years later, in 1999, and our understanding of the physiological significance of the ghrelin system in vertebrates has grown steadily since then. Although the ghrelin system in non-mammalian vertebrates is a subject of great interest, protein sequence data for the receptor in non-mammalian vertebrates has been limited until recently, and related biological information has not been well organized. In this review, we summarize current information related to the ghrelin receptor in non-mammalian vertebrates.
authors.affiliation: Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute , Osaka , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kaiya
authors.forename: Kenji
authors.initials: K
authors.lastname: Kangawa
authors.forename: Mikiya
authors.initials: M
authors.lastname: Miyazato
keywords: GHS-R; GHS-R-like receptor; amphibians; birds; fishes; ghrelin; ghrelin receptor; reptiles