title: Crohn's disease complicated by intestinal infection with methicillin-resistant Staphylococcus aureus.
abstract: We report on a 24-year-old male patient with history of bloody diarrhea, abdominal pain and vomiting. Endoscopy revealed massive ulcerative discontinuous proctosigmoiditis with deep, sharply demarcated epithelial denudations and enterotoxigenic methicillin-resistant Staphylococcus aureus (MRSA) was detected in mucosal biopsies. After treatment with linezolide and steroids, a significant amelioration of colitis was detected and testing for MRSA became negative. In face of the case presented here, we suggest that in patients with refractory inflammatory bowel disease (IBD), microbiological assessment should be performed to detect a possible Staphylococcus aureus infection in order to initiate an antimicrobial treatment in addition to IBD-specific treatment.
authors.affiliation: Department of Medicine B, University of Münster, D-48149 Münster, Germany. dominik.bettenworth@ukmuenster.de
authors.forename: Dominik
authors.initials: D
authors.lastname: Bettenworth
authors.forename: Tobias M
authors.initials: TM
authors.lastname: Nowacki
authors.forename: Alexander
authors.initials: A
authors.lastname: Friedrich
authors.forename: Karsten
authors.initials: K
authors.lastname: Becker
authors.forename: Johannes
authors.initials: J
authors.lastname: Wessling
authors.forename: Jan
authors.initials: J
authors.lastname: Heidemann
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D003092:Colitis / Q000382:microbiology* / Q000473:pathology; D003424:Crohn Disease / Q000150:complications* / Q000382:microbiology; D003428:Cross Infection / Q000150:complications / Q000382:microbiology; D004724:Endoscopy; D006801:Humans; D007249:Inflammation / Q000382:microbiology / Q000473:pathology; D007422:Intestines / Q000382:microbiology* / Q000473:pathology; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D013203:Staphylococcal Infections / Q000150:complications* / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents
keywords: Crohn’s disease; Infectious colitis; Inflammatory bowel disease; Methicillin-resistant Staphylococcus aureus; Staphylococcus aureus