title: In vivo growth inhibition of sarcoma 180 by Kielmeyera rugosa Choisy (Calophyllaceae).
abstract: The plant Kielmeyera rugosa Choisy (family Calophyllaceae), popularly known as 'pau-santo', is traditionally used in Brazilian folk medicine. Recently, the dichloromethane extract-dichloromethane partition from stems of K. rugosa (KR) has shown positive results in our cytotoxic screening programme. Therefore, the aim of this study was to validate the antitumour activity of KR on sarcoma 180 tumour-bearing mice. KR showed antitumour activity with both administration routes: intraperitoneal (50 and 100 mg/kg/day) and oral (100 and 200 mg/kg/day). Tumour growth inhibition rates were 40.8-34.9% and 25.4-51.8% after intraperitoneal and oral administrations, respectively. Treatment with KR did not significantly affect body mass, macroscopy of the organs or blood leukocyte counts. In conclusion, KR exhibited an in vivo antitumour effect without substantial toxicity.
authors.affiliation: a Department of Physiology , Federal University of Sergipe , Av. Marechal Rondon, Jardim Rosa Elze, 49100-000 , São Cristóvão Sergipe Brazil.
authors.forename: A C A
authors.initials: AC
authors.lastname: Oliveira
authors.forename: A C S
authors.initials: AC
authors.lastname: Britto
authors.forename: R M
authors.initials: RM
authors.lastname: Henriques
authors.forename: G M B
authors.initials: GM
authors.lastname: Cardoso
authors.forename: C S
authors.initials: CS
authors.lastname: Anjos
authors.forename: A M
authors.initials: AM
authors.lastname: Jesus
authors.forename: E V
authors.initials: EV
authors.lastname: Costa
authors.forename: V R S
authors.initials: VR
authors.lastname: Moraes
authors.forename: P C L
authors.initials: PC
authors.lastname: Nogueira
authors.forename: D P
authors.initials: DP
authors.lastname: Bezerra
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D029581:Malpighiaceae / Q000737:chemistry*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D012509:Sarcoma / Q000473:pathology*
chemical_list: D010936:Plant Extracts