title: Detection of DNA induced gold nanoparticle aggregation with dark field imaging.
abstract: Dark field imaging was employed to visualize and quantify complementary DNA-induced gold nanoparticle aggregation at the single-particle level, with a detection limit of 100 fM DNA, which allows the highly sensitive detection of single nucleotide polymorphisms (SNPs). Results suggested that the aggregation process is consistent with the cluster-cluster model.
authors.affiliation: Department of Advanced Materials Science, School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 227-8561, Japan.
authors.forename: Tong
authors.initials: T
authors.lastname: Bu
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Zako
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fujita
authors.forename: Mizuo
authors.initials: M
authors.lastname: Maeda
mesh_terms: D004247:DNA / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008853:Microscopy; D010316:Particle Size; D020641:Polymorphism, Single Nucleotide; D013499:Surface Properties
chemical_list: D006046:Gold; D004247:DNA