title: Electrospinning of ibuprofen-loaded composite nanofibers for improving the performances of transdermal patches.
abstract: The main aim of the present study was to electrospin ibuprofen (IBU)-loaded composite nanofibers to improve the performances of transdermal patches. Cellulose acetate/poly(vinyl pyrrolidone) (CA/PVP) blends were used to fabricate uniform nanofibers. Investigations on the physicochemical properties of CA/PVP solutions indicated that the addition of appropriate PVP improved the electrospinnability of original CA solutions. Detections on the physical states of IBU in medicated CA/PVP nanofibers suggested that IBU was uniformly distributed in nanofibers in an amorphous state. Comparing to IBU-loaded casting membrane, the medicated CA/PVP nanofibers provided a faster IBU diffusion manner and a better ex vitro skin permeation profile due to their high superficial areas and the amorphous IBU. Furthermore, CA/PVP nanofibers exhibited a high water vapor permeability, which could render an improved breathability to transdermal patches. In sum, the electrospun drug-loaded CA/PVP nanofibers exhibited great potentials to improve the thermodynamic stability and breathability of transdermal patches, which could be used to develop new types of transdermal drug delivery system (TDDS).
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, 300072 Tianjin, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Shi
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wei
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Anjie
authors.initials: A
authors.lastname: Dong
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002152:Calorimetry, Differential Scanning; D007052:Ibuprofen / Q000008:administration & dosage*; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers; D013500:Surface Tension; D013552:Swine; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen