title: Breast phyllodes tumor: a review of literature and a single center retrospective series analysis.
abstract: OBJECTIVE
  Complete surgical resection is the standard treatment for localized breast phyllodes tumors. Post-surgical treatments are still a matter of debate. We carried out an overview of the literature to investigate the clinical outcome of patients with phyllodes tumor. A retrospective analysis of mono-institutional series has been included as well.
  
  
  METHODS
  We reviewed all the retrospective series reported from 1951 until April 2012. We analyzed cases treated at our institution from 1999 to 2010.
  
  
  RESULTS
  Eighty-three articles (5530 patients; 1956 malignant tumors) were reviewed. Local recurrences were independent of histology. Distant recurrences were more frequent in the malignant tumors (22%). A total of 172 phyllodes tumors were included in the retrospective analysis.
  
  
  CONCLUSIONS
  Prognosis of phyllodes tumors is excellent. There are no convincing data to recommend any adjuvant treatment after surgery. Molecular characterization may well provide new clues to permit identification of active treatments for the rare poor prognosis cases.
authors.affiliation: Department of Medicine, European Institute of Oncology, Milan, Italy. Electronic address: gianluca.spitaleri@ieo.it.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Spitaleri
authors.forename: Antonio
authors.initials: A
authors.lastname: Toesca
authors.forename: Edoardo
authors.initials: E
authors.lastname: Botteri
authors.forename: Luca
authors.initials: L
authors.lastname: Bottiglieri
authors.forename: Nicole
authors.initials: N
authors.lastname: Rotmensz
authors.forename: Sabrina
authors.initials: S
authors.lastname: Boselli
authors.forename: Claudia
authors.initials: C
authors.lastname: Sangalli
authors.forename: Chiara
authors.initials: C
authors.lastname: Catania
authors.forename: Francesca
authors.initials: F
authors.lastname: Toffalorio
authors.forename: Cristina
authors.initials: C
authors.lastname: Noberasco
authors.forename: Angelo
authors.initials: A
authors.lastname: Delmonte
authors.forename: Alberto
authors.initials: A
authors.lastname: Luini
authors.forename: Paolo
authors.initials: P
authors.lastname: Veronesi
authors.forename: Marco
authors.initials: M
authors.lastname: Colleoni
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Viale
authors.forename: Stefano
authors.initials: S
authors.lastname: Zurrida
authors.forename: Aron
authors.initials: A
authors.lastname: Goldhirsch
authors.forename: Umberto
authors.initials: U
authors.lastname: Veronesi
authors.forename: Tommaso
authors.initials: T
authors.lastname: De Pas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001943:Breast Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D018567:Breast Neoplasms, Male / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D003557:Phyllodes Tumor / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Breast tumors; Literature overview; Phyllodes tumor; Prognosis; Retrospective analysis