title: Towards a general synthesis of 3-metal-substituted β-lactams.
abstract: Joining metals and antibiotics: Studies towards a general method for the synthesis of β-lactams that have a metal complex moiety attached to the C3-position are reported (see scheme). The cis/trans selectivity of the reactions ranges from low in complexes containing the alkyne moiety joined directly to the cyclopentadienyl ring to complete when the metal moiety is separated from the reactive alkyne by an alkynyl-aryl fragment.
authors.affiliation: Dpto. de Química Orgánica, Facultad de Química, Universidad Complutense, 28040 Madrid, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Baeza
authors.forename: Luis
authors.initials: L
authors.lastname: Casarrubios
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sierra
keywords: Kinugasa reaction; alkynyl metals; antibiotics; lactams; nitrones