title: Managing uncontrolled postsplenectomy reactive thrombocytosis in idiopathic thrombocytopenic purpura: role of thrombocytapheresis.
abstract: Reactive thrombocytosis occurs in response to infection, trauma, or surgery. Splenectomy alone accounts for 19% of all possible causes of extreme thrombocytosis. We performed thrombocytapheresis in a young lady with chronic idiopathic thrombocytopenic purpura (ITP) who developed postsplenectomy reactive thrombocytosis. Her post splenectomy platelet count was 227 × 10(6)/ml which elevated to 1623 × 10(6)/ml on the 7th postoperative day. A single thrombocytapheresis procedure reduced her platelet to 403 × 10(6)/ml. She was discharged on the 10th postoperative day and then maintained a count of 204-238 × 10(6)/ml with aspirin. Thrombocytapheresis reduces the platelet count rapidly in thrombocytosis and prevents patients from having thrombotic events. However, such procedures should be performed very meticulously to ensure patient safety.
authors.affiliation: Dept. of Transfusion Medicine, Apollo Gleneagles Hospitals, Kolkata 700 054, India. Electronic address: sudipta.sgpgi@yahoo.co.in.
authors.forename: Sudipta Sekhar
authors.initials: SS
authors.lastname: Das
authors.forename: Soumya
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Subrata
authors.initials: S
authors.lastname: Sen
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010983:Plateletpheresis; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy*; D011696:Purpura, Thrombocytopenic / Q000473:pathology / Q000601:surgery*; D013156:Splenectomy / Q000009:adverse effects*; D013922:Thrombocytosis / Q000209:etiology / Q000628:therapy*; D013997:Time Factors
keywords: Cell separator; Platelet; Plateletpheresis; Thrombocytapheresis; Thrombocytosis