title: The endovascular occlusion system for safe and immediate peripheral vessel occlusion during vascular interventions.
abstract: Endovascular occlusion of blood vessels is an important part of interventional therapy concepts. Here, we evaluate the feasibility, procedural safety and efficacy of the novel endovascular occlusion system (EOS) in the arterial system in a porcine model. Thirteen devices were deployed in the iliac and femoral arteries (diameter: 4-5 mm) of five adult swine. Post-deployment angiography was performed at 1, 5 and 10 min and 6 h. All devices (n = 13) could be successfully delivered without any complications, such as dissection, perforation or rupture. The devices could be easily advanced to the target vessel segment, deployed at the intended target location and produced immediate and complete vessel occlusion which was confirmed to be maintained after 6 h. No leaks, recanalization or device migration was observed. In this pilot study, we demonstrate the feasibility, safety and efficacy of immediate vessel occlusion with the EOS device in the peripheral arterial system in a porcine animal model. Our data indicate that this novel device allows precise delivery without the occurrence of cardiovascular complications. Owing to its long-term safety and efficacy the EOS may represent a promising and effective alternative to currently available devices for vessel occlusion during vascular interventions.
authors.affiliation: Clinic for Cardiac and Vascular Surgery, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Maximilian Y
authors.initials: MY
authors.lastname: Emmert
authors.forename: Anthony
authors.initials: A
authors.lastname: Venbrux
authors.forename: Leon
authors.initials: L
authors.lastname: Rudakov
authors.forename: Nikola
authors.initials: N
authors.lastname: Cesarovic
authors.forename: Martin G
authors.initials: MG
authors.lastname: Radvany
authors.forename: Philippe
authors.initials: P
authors.lastname: Gailloud
authors.forename: Volkmar
authors.initials: V
authors.lastname: Falk
authors.forename: Andre
authors.initials: A
authors.lastname: Plass
mesh_terms: D000818:Animals; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation*; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation*; D004867:Equipment Design; D005240:Feasibility Studies; D005263:Femoral Artery / Q000000981:diagnostic imaging; D007083:Iliac Artery / Q000000981:diagnostic imaging; D023421:Models, Animal; D010865:Pilot Projects; D011859:Radiography; D013552:Swine; D062666:Vascular Access Devices
keywords: Embolization; Endovascular; Occlusion device; Vessel occlusion