title: [Rokitansky's theory of humoral pathology, virchow's theory of cellular pathology, and new phylogenetic theory of diseases. Etiology and pathogenesis of "metabolic pandemics"].
abstract: Virchow's theory of cellular pathology contains indirect indications that a) there are in vivo structural and functional units between the cell and the organ and b) common mechanisms operate in health and disease. It is proposed to use the phylogenetic theory to obtain an insight into the unified pathogenetic mechanism of atherosclerosis, diabetes mellitus, metabolic syndrome. and obesity. It includes 1) consideration of in vivo physiological and pathological processes in the context of biological functions and reactions, 2) phylogenesis of metabolic regulation at three levels: a) cellular (autocrine), b) paracrine cell communities (structural and functional units of each organ), c) organismic. Biological functions are trophologic, homeostatic, endoecological ("cleanliness" of intercellular medium), adaptive, locomotor reproductive and cognitive. 3) consideration of the successive three-step development of biological functions and reactions of pathological process in phylogenesis. Technical tools in phylogenesis include a) continuity, of formation of biological functions and reactions, b) biological subordination (later formed humoral mediators can not reverse effect of the phylogenetically earlier ones). Inconsistency of humoral regulation at different phylogenetic levels (autocrine, paracrine, organismic) constitutes the basis for common pathogenesis of all metabolic pandemics inclutding essential AH and insulin resistance.
authors.forename: V N
authors.initials: VN
authors.lastname: Titiov
mesh_terms: D019898:Autocrine Communication; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D008962:Models, Theoretical; D019899:Paracrine Communication; D010802:Phylogeny