title: Study of methacholine positivity in patients with chronic cough at Masih Daneshvari hospital, Tehran, 2007-2008.
abstract: While airways reactivity is among the characteristics of asthma, it is not considered a sufficient condition diagnostically and the methacholine challenge is a non-specific diagnostic aid in cases of chronic cough and reactive airways disease. The aim of this cross-sectional study was to determine the metacholine response positivity and diagnosis of asthma in patients with chronic cough presenting to a hospital in Tehran during 2007 and 2008. Of 101 patients with chronic cough (with no history of sinusitis, recent pulmonary infection, bronchitis, gasteroesophageal reflux or underlying pulmonary conditions), 51.5% showed reactive airways disease to the methacholine test, 40.6% were unreactive and 7.9% were indeterminate. A positive methacholine challenge test was positively correlated with new wheezing. Although the methacholine challenge test is not a primary test for evaluating chronic cough, if no other reason for chronic cough is found, it may be a guiding test for asthma.
authors.affiliation: Lung Transplantation Research Centre, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of lran. cheraghvandiali@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Cheraghvandi
authors.forename: L
authors.initials: L
authors.lastname: Fadaizadeh
authors.forename: S A
authors.initials: SA
authors.lastname: Taheri
authors.forename: M R
authors.initials: MR
authors.lastname: Masjedi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism; D001985:Bronchial Provocation Tests; D002908:Chronic Disease; D003371:Cough / Q000453:epidemiology* / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D016210:Methacholine Chloride / Q000378:metabolism; D008875:Middle Aged; D012129:Respiratory Function Tests; D012135:Respiratory Sounds; D055815:Young Adult
chemical_list: D016210:Methacholine Chloride