title: [Research progresses in cancer stem cell and its vascular microenvironment].
abstract: Cancer stem cells (CSCs) and angiogenesis play important roles in generation and development of malignant tumours. The number of researches concerned both of them is increasing rapidly and many impressive conclusions have been achieved based on recent studies. It is indicated that the CSCs have complicated interaction with the adjacent vascular microenvironment and they act on the disease progression together. CSCs may enhance angiogenesis while the vascular microenvironment has effects on maintenance and even induction of stemness, and new illustrations of mechanisms are constantly obtained. In this review, we summarize the current research status of mutual actions between CSCs and the vascular microenvironment, and also overview the latest progresses about relevant targeted therapies, to provide advisable information for future preclinical and clinical explorations.
authors.affiliation: West China Medicine School, Sichuan University, Chengdu 610041, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Deng
authors.forename: You
authors.initials: Y
authors.lastname: Lu
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000473:pathology / Q000503:physiopathology*; D059016:Tumor Microenvironment