title: The effect of Lacto- and Bifidobacteria in monoculture on the vaginal microflora in norm and in cases of intravaginal staphylococcosis.
abstract: The influence of probiotic strains of Lactobacillus casei IMV B-7280, Lactobacillus acidophilus IMV B-7279, Bifidobacterium animalis VKL, Lactobacillus delbrueckii subsp. bulgaricus IMV B-7281 and Bifidobacterium animalis VKB, each strain separately, to the range of the urogenital tract microflora in physiological norm and in cases of experimental intravaginal staphylococcosis of mice induced by Staphylococcus aureus 8325-4. It was found that all these strains had different efficiency in Staphylococcus aureus 8325-4 growth suppression in the vagina of infected mice and affect the spectrum of microorganisms. Lactobacillus casei IMV B-7280 strain had effective antistaphylococcal effect and reduced the number of coliform bacteria and fungi in the vagina in cases of intravaginal staphylococcosis of mice. Lactobacillus casei IMV B-7280 strain is promising to create probiotic drugs effective in treating intravaginal staphylococcosis.
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny St., Kyiv D03680, Ukraine.
authors.forename: L R
authors.initials: LR
authors.lastname: Babenko
authors.forename: L M
authors.initials: LM
authors.lastname: Lazarenko
authors.forename: L M
authors.initials: LM
authors.lastname: Shynkarenko
authors.forename: V V
authors.initials: VV
authors.lastname: Mokrozub
authors.forename: V S
authors.initials: VS
authors.lastname: Pidgorskyi
authors.forename: M Ja
authors.initials: MJ
authors.lastname: Spivak
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D000898:Antibiosis; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D014621:Vagina / Q000187:drug effects / Q000382:microbiology*; D016585:Vaginosis, Bacterial / Q000188:drug therapy* / Q000382:microbiology