title: A single-parameter logistic equation for fitting concentration-response curves from standard acute ecotoxicity assays.
abstract: A set of 69 concentration-response curves from 5 acute ecotoxicity assays was fitted with a 2-parameter logistic equation. High correlation between values of regression parameters suggested similar slopes of the curves. This enabled derivation of the empirical single-parameter logistic equation with the sole median effective concentration (EC50) parameter. Such an equation might be useful in the evaluation of lower-quality (preliminary) experimental data and for the reduction of the number of test organisms and of testing costs.
authors.affiliation: Faculty of Environment, Jan Evangelista Purkyně University in Ústí nad Labem, Czech Republic. josef.trogl@ujep.cz
authors.forename: Josef
authors.initials: J
authors.lastname: Trögl
authors.forename: Kateřina
authors.initials: K
authors.lastname: Benediktová
authors.forename: Věra
authors.initials: V
authors.lastname: Pilařová
authors.forename: Václav
authors.initials: V
authors.lastname: Synek
mesh_terms: D048908:Aliivibrio fischeri / Q000187:drug effects; D000818:Animals; D000460:Chlorophyta / Q000187:drug effects; D003621:Daphnia / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D016015:Logistic Models; D011036:Poecilia; D011192:Potassium Dichromate / Q000633:toxicity; D012015:Reference Standards; D023382:Toxicity Tests, Acute / Q000592:standards
chemical_list: D004785:Environmental Pollutants; D011192:Potassium Dichromate
keywords: Acute ecotoxicity assays; Concentration-response slope; EC50 calculation; Logistic model