title: Accuracy of diagnostic methods and surveillance sensitivity for human enterovirus, South Korea, 1999-2011.
abstract: The epidemiology of enteroviral infection in South Korea during 1999-2011 chronicles nationwide outbreaks and changing detection and subtyping methods used over the 13-year period. Of 14,657 patients whose samples were tested, 4,762 (32.5%) samples were positive for human enterovirus (human EV); as diagnostic methods improved, the rate of positive results increased. A seasonal trend of outbreaks was documented. Genotypes enterovirus 71, echovirus 30, coxsackievirus B5, enterovirus 6, and coxsackievirus B2 were the most common genotypes identified. Accurate test results correlated clinical syndromes to enterovirus genotypes: aseptic meningitis to echovirus 30, enterovirus 6, and coxsackievirus B5; hand, foot and mouth disease to coxsackievirus A16; and hand, foot and mouth disease with neurologic complications to enterovirus 71. There are currently no treatments specific to human EV infections; surveillance of enterovirus infections such as this study provides may assist with evaluating the need to research and develop treatments for infections caused by virulent human EV genotypes.
authors.affiliation: Korea Center for Disease Control and Prevention, Cheongwon-gun, Chungcheongbuk-do, South Korea.
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Hyeon
authors.forename: Seoyeon
authors.initials: S
authors.lastname: Hwang
authors.forename: Hyejin
authors.initials: H
authors.lastname: Kim
authors.forename: Jaehyoung
authors.initials: J
authors.lastname: Song
authors.forename: Jeongbae
authors.initials: J
authors.lastname: Ahn
authors.forename: Byunghak
authors.initials: B
authors.lastname: Kang
authors.forename: Kisoon
authors.initials: K
authors.lastname: Kim
authors.forename: Wooyoung
authors.initials: W
authors.lastname: Choi
authors.forename: Jae Keun
authors.initials: JK
authors.lastname: Chung
authors.forename: Cheon-Hyun
authors.initials: CH
authors.lastname: Kim
authors.forename: Kyungsoon
authors.initials: K
authors.lastname: Cho
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Jee
authors.forename: Jonghyun
authors.initials: J
authors.lastname: Kim
authors.forename: Kisang
authors.initials: K
authors.lastname: Kim
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Min-Ji
authors.initials: MJ
authors.lastname: Kim
authors.forename: Doo-Sung
authors.initials: DS
authors.lastname: Cheon
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D036022:Capsid Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003951:Diagnostic Errors; D004196:Disease Outbreaks; D004770:Enterovirus / Q000235:genetics*; D004769:Enterovirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D062665:Epidemiological Monitoring; D005838:Genotype; D006801:Humans; D007223:Infant; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D058889:Molecular Typing; D015995:Prevalence; D060888:Real-Time Polymerase Chain Reaction; D056910:Republic of Korea / Q000453:epidemiology; D012621:Seasons; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D036022:Capsid Proteins
keywords: Korea Centers for Disease Control and Prevention; RT-PCR; South Korea; cell culture; genotype; human enterovirus; prevalence; real time RT-PCR; surveillance; the Republic of Korea; viruses