title: Evaluation of association between airway hyperresponsiveness, asthma control test, and asthma therapy assessment questionnaire in asthmatic children.
abstract: BACKGROUND
  Achieving asthma control is a major challenge in children, otherwise symptoms perception remain poor especially at this age. The aim of this study is to evaluate the relationship between Asthma Control Test (ACTTM), Asthma Therapy Assessment Questionnaire (ATAQTM) and exercise-induced bronchospasm (EIB).
  
  
  METHODS
  We studied 80 asthmatic children. Airways hyperresponsiveness (AHR) was assessed by exercise-induced bronchospasm (Balke Protocol). Asthma control was evaluated using two questionnaires in all subjects: ACT (composed by Childhood-ACT and ACT) and ATAQ. In addition the use of short acting beta 2 agonist agents (SABAs) was assessed for each patient. Non-parametric variables were compared by Chi Square Test. Binomial logistic regression was performed to estimate the two questionnaires Odds Ratio (OR) in finding AHR.
  
  
  RESULTS
  We have found that ATAQ has a sensitivity and a specificity of 0.72 and 0.45 respectively; instead, ACT has a sensitivity and a specificity of 0.5 and 0.39 respectively in evaluating AHR. Patients with uncontrolled asthma according to ATAQ revealed a significant higher percentage of AHR compared with ACT (72% vs 50%, p < 0.01).Confirming this finding, patients declaring uncontrolled asthma to ATAQ have a significantly higher percentage (34%) of frequent SABAs use than the group with uncontrolled asthma to ACT (21%) (p <0.01).Binomial logistic regression shows how a test revealing uncontrolled asthma is associated with the increasing odds of having AHR according to ATAQ (OR = 3.8, p = 0.05), not to ACT (OR = 0.2, p = 0.1).
  
  
  CONCLUSIONS
  Our results show that ATAQ reflects AHR and asthma control better than ACT. Children with uncontrolled asthma according to ATAQ have higher odds of having AHR and use of rescue medications (SABAs) compared to patients declaring uncontrolled asthma according to ACT. However both questionnaires are not sufficient alone to fully evaluate asthma control in children and it is always necessary to perform functional tests and investigate patients lifestyle, drug use and other important data that a simple questionnaire is not able to point out.
authors.affiliation: Allergy and Respiratory Unit, Department of Pediatrics, G, D'Annunzio University of Chieti, Via Dei Vestini 5, Chieti 66013, Italy. rapino.daniele@gmail.com.
authors.forename: Daniele
authors.initials: D
authors.lastname: Rapino
authors.forename: Marina
authors.initials: M
authors.lastname: Attanasi
authors.forename: Nicola P
authors.initials: NP
authors.lastname: Consilvio
authors.forename: Alessandra
authors.initials: A
authors.lastname: Scaparrotta
authors.forename: Anna
authors.initials: A
authors.lastname: Cingolani
authors.forename: Marzia
authors.initials: M
authors.lastname: Cerasa
authors.forename: Angelika
authors.initials: A
authors.lastname: Mohn
authors.forename: Sabrina
authors.initials: S
authors.lastname: Di Pillo
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiarelli