title: Current status of sentinel lymph node mapping in the management of cervical cancer.
abstract: The status of regional lymph nodes is the most important prognostic factor in early cervical cancer patients. Pelvic lymph node dissections are routinely performed as a part of standard surgical treatment. Systematic pelvic lymphadenectomy is associated with short- and long-term morbidities. This review discusses single components of the sentinel lymph node mapping (SLNM) technique and results of the detection of sentinel lymph nodes. SLNM biopsy performed by an experienced team for small volume tumors (<2 cm) has high specific side detection rate, excellent negative-predictive value and high sensitivity. Uncommon lymphatic drainage has been reported in 15% of cervical cancer patients. There is sufficient data now to suggest that SLNM with 99mTc plus blue dye in the hands of a surgeon with extensive experience should prove to be an important part of individualized cervical cancer surgery and increase the safety of less radical or fertility-sparing surgery.
authors.forename: Lukas
authors.initials: L
authors.lastname: Rob
authors.affiliation: Department of Obstetrics and Gynecology, 2nd Medical Faculty, Charles University, V uvalu 84, 150 00 Prague 5. lukas.rob@lfmotol.cuni.cz
authors.forename: Rob
authors.initials: R
authors.lastname: Lukas
authors.forename: Helena
authors.initials: H
authors.lastname: Robova
authors.forename: Robova
authors.initials: R
authors.lastname: Helena
authors.forename: Michael Jiri
authors.initials: MJ
authors.lastname: Halaska
authors.forename: Halaska Michael
authors.initials: HM
authors.lastname: Jiri
authors.forename: Martin
authors.initials: M
authors.lastname: Hruda
authors.forename: Hruda
authors.initials: H
authors.lastname: Martin
authors.forename: Petr
authors.initials: P
authors.lastname: Skapa
authors.forename: Skapa
authors.initials: S
authors.lastname: Petr
mesh_terms: D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D013667:Technetium; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000628:therapy
chemical_list: D013667:Technetium