title: Final adult height in kidney recipients who underwent highly successful transplantation as children: a single-center experience.
abstract: BACKGROUND
  Achieving a normal final adult height (FH) remains a challenge in the field of pediatric kidney transplantation (KTx). To examine the optimal approach to assuring normal FH following KTx, we retrospectively examined the post-transplant growth and FH of pediatric KTx recipients.
  
  
  METHODS
  Since the relevant factors affecting the FH of children following KTx are multifactorial and notably complex, KTx recipients with persistent good graft function and successful steroid minimization until FH attainment were selected for this study.
  
  
  RESULTS
  Thirteen patients were enrolled in this study. The mean estimated glomerular filtration rate was 72.1 ± 15.3 ml/min/1.73 m(2), and the mean corticosteroid dose was 0.05 ± 0.05 mg/kg on alternate days at the time of FH attainment. Despite highly successful KTx, four (30.8 %) patients (one who underwent KTx before puberty and three during puberty) showed a decrease in the height standard deviation score (hSDS) from the time of KTx until FH attainment. Moreover, of these, two male patients had an FH with an SD <-2.
  
  
  CONCLUSIONS
  FH remained suboptimal despite highly successful KTx. Not only highly successful KTx but also further treatment such as steroid avoidance, early steroid withdrawal or using rhGH might be necessary to assure a normal FH in some pubertal patients.
authors.affiliation: Department of Pediatrics, Koseiren Hiroshima General Hospital, 1-3-3 Zigozen, Hatsukaichi-shi, Hiroshima, 738-8503, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujii
authors.forename: Hiroko
authors.initials: H
authors.lastname: Chikamoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Akioka
authors.forename: Motoshi
authors.initials: M
authors.lastname: Hattori
mesh_terms: D000305:Adrenal Cortex Hormones; D000328:Adult; D000367:Age Factors; D001827:Body Height / Q000187:drug effects / Q000502:physiology*; D002648:Child; D000075202:Contraindications; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation; D008297:Male; D012189:Retrospective Studies; D066027:Transplant Recipients
chemical_list: D000305:Adrenal Cortex Hormones; D013006:Growth Hormone