title: Protective effect of total phenylethanoid glycosides from Monochasma savatieri Franch on myocardial ischemia injury.
abstract: The present study was designed to investigate the cardioprotective effect of total phenylethanoid glycosides from Monochasma savatieri Franch (TPG). The data showed that there were mainly four phenylethanoid glycosides isolated and identified from TPG. TPG significantly increased cells viability and inhibited morphological changes on H9c2 cardiomyocytes induced by H2O2 or Na2S2O4. In addition, TPG significantly decreased T-wave elevation and histopathological changes of heart tissues in myocardial infracted rats induced by isoproterenol. It also significantly reduced the infarct size induced by ligating the coronary artery in rats, increased the activities of antioxidative enzymes superoxide dismutase (SOD), the content of glutathione (GSH), and decreased the leakage of lactic dehydrogenase (LDH), the activities of creatine kinase (CK) and the content of maleic dialdehyde (MDA). In conclusion, these results suggested that TPG from Monochasma savatieri Franch might be developed as new natural medicine or food additives with effects of prevention of coronary artery disease due to its significant antioxidant activity.
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
authors.forename: Mengfan
authors.initials: M
authors.lastname: Shi
authors.forename: Wenjun
authors.initials: W
authors.lastname: He
authors.forename: Yanli
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaoran
authors.initials: X
authors.lastname: Li
authors.forename: Shilin
authors.initials: S
authors.lastname: Yang
authors.forename: Qiongming
authors.initials: Q
authors.lastname: Xu
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D006861:Hydrogen Peroxide; D007545:Isoproterenol; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D032383:Myocytes, Cardiac / Q000187:drug effects; D031670:Orobanchaceae / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002316:Cardiotonic Agents; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; D006861:Hydrogen Peroxide; D007545:Isoproterenol
keywords: Antioxidant; Cardiac oxidative injury; Monochasma savatieri Franch; Myocardial ischemia; Phenylethanoid glycosides