title: Improvement of measurement method for hydroxylated polychlorinated biphenyls (OH-PCBs) in blood samples using LC/MS/MS.
abstract: Hydroxylated polychlorinated biphenyls (OH-PCBs) are well known as metabolites of PCBs in the human body. We improved a measurement method for OH-PCBs in blood samples using LC/MS/MS. A new 2 microm particle column was used, and the analytical conditions for the LC/MS/MS measurements were optimized. The improved method is more sensitive than the conventional method for 5g blood samples. And, this method is effective at determining the concentrations of OH-PCBs, PCBs and dioxins from the same sample without special treatment of the sample such as derivatization.
authors.affiliation: Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka, Japan. tobiishi@fihes.pref.fukuoka.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tobiishi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Todaka
authors.forename: Hironori
authors.initials: H
authors.lastname: Hirakawa
authors.forename: Tsuguhide
authors.initials: T
authors.lastname: Hori
authors.forename: Jumboku
authors.initials: J
authors.lastname: Kajiwara
authors.forename: Teruaki
authors.initials: T
authors.lastname: Hirata
authors.forename: Takao
authors.initials: T
authors.lastname: Iida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchi
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods; D002853:Chromatography, Liquid; D006801:Humans; D006900:Hydroxylation; D011078:Polychlorinated Biphenyls / Q000097:blood*; D053719:Tandem Mass Spectrometry
chemical_list: D011078:Polychlorinated Biphenyls