title: Development of second generation gold-supported palladium material with low-leaching and recyclable characteristics in aromatic amination.
abstract: An improved process for the preparation of sulfur-modified gold-supported palladium material [SAPd, second generation] is presented. The developed preparation method is safer and generates less heat (aqueous Na2S2O8 and H2SO4) for sulfur fixation on a gold surface, and it is superior to the previous method of preparing SAPd (first generation), which requires the use of the more heat-generating and dangerous piranha solution (concentrated H2SO4 and 35% H2O2) in the sulfur fixation step. This safer and improved preparation method is particularly important for the mass production of SAPd (second generation) for which the catalytic activity was examined in ligand-free Buchwald-Hartwig cross-coupling reactions. The catalytic activities were the same between the first and second generation SAPds in aromatic aminations, but the lower palladium leaching properties and safer preparative method of second generation SAPd are a significant improvement over the first generation SAPd.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Al-Amin
authors.forename: Satoshi
authors.initials: S
authors.lastname: Arai
authors.forename: Naoyoki
authors.initials: N
authors.lastname: Hoshiya
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Honma
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tamenori
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Sato
authors.forename: Mami
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Akira
authors.initials: A
authors.lastname: Ishii
authors.forename: Masashi
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maruko
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shuto
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Arisawa
mesh_terms: D000586:Amination; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D009942:Organometallic Compounds; D010165:Palladium; D006046:Gold; C023650:aniline