title: Anodic TiO2 nanotubular arrays with pre-synthesized hydroxyapatite--an effective approach to enhance the biocompatibility of titanium.
abstract: Electrochemically anodized TiO2 nanotubular arrays can provide large surface areas for biological species attachment. In order to further enhance the biocompatibility of Ti medical implants, we deposited a pre-synthesized hydroxyapatite inside and on the nanotubular arrays, and examined the biocompatibility of the anodized TiO2 nanotubular arrays with pre-synthesized hydroxyapatite by in vitro assessment in simulated body fluid, and in vitro cell culture. The results showed that the hydroxyapatite coating was able to be induced on TiO2 nanotubular arrays with pre-synthesized hydroxyapatite within 5 days while only a thin film composed of calcium phosphorous chemicals formed on as-formed TiO2 nanotubular arrays. The cell culture evaluation further proved the enhancement of cell attachment and proliferation on TiO2 nanotubular arrays with pre-synthesized hydroxyapatite as opposed to those without pre-synthesized hydroxyapatite. The present study proves that formation of TiO2 nanotubular arrays with pre-synthesized hydroxyapatite a promising method to enhance the biocompatibility of Ti implants.
authors.affiliation: School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
authors.forename: Lu-Ning
authors.initials: LN
authors.lastname: Wang
authors.forename: Long-Xiang
authors.initials: LX
authors.lastname: Lin
authors.forename: Chang-Jian
authors.initials: CJ
authors.lastname: Lin
authors.forename: Chen
authors.initials: C
authors.lastname: Shen
authors.forename: Alyssa
authors.initials: A
authors.lastname: Shinbine
authors.forename: Jing-Li
authors.initials: JL
authors.lastname: Luo
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D002460:Cell Line; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D006801:Humans; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium