title: Splanchnic vein thrombosis following renal transplantation: a case report.
abstract: BACKGROUND
  Recurrent episodes of venous thrombosis have been closely correlated with JAK2 V617F mutation. Upto date, JAK2 gene mutation has not been defined as a prothrombic risk factor in renal transplant recipients. Herein; we present a case of portosplenic vein thrombosis in a primary renal transplant recipient with JAK2 V617F mutation who had no history of prior venous thromboembolism or thrombophilia.
  
  
  METHODS
  A 59 year old female caucasian patient with primary kidney transplant admitted with vague abdominal pain at left upper quadrant. Abdominal doppler ultrasound and magnetic resonance imaging angiography demonstrated splanchnic vein thrombosis (SVT). The final diagnosis was SVT due to MPD (essential thrombocytosis, ET) with JAK2 V617F mutation. After 3 months of treatment with warfarin (≥5 mg/day, to keep target INR values of 1.9-2.5), control MRI angiography and doppler USG demonstrated partial (>%50) resolution of thrombosis with recanalization of hepatopedal venous flow. The patient is still on the same treatment protocol without any complication.
  
  
  CONCLUSIONS
  JAK2 V617F mutation analysis should be a routine procedure in the diagnosis and treatment of kidney transplant patients with thrombosis in uncommon sites.
authors.forename: Erhan
authors.initials: E
authors.lastname: Tatar
authors.forename: Adam
authors.initials: A
authors.lastname: Uslu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Aykas
authors.forename: Funda
authors.initials: F
authors.lastname: Tasli
authors.forename: Ozgur
authors.initials: O
authors.lastname: Oztekin
authors.forename: Gulsum Akgun
authors.initials: GA
authors.lastname: Cagliyan
mesh_terms: D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D011183:Postoperative Complications; D013152:Splanchnic Circulation / Q000502:physiology; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000209:etiology*