title: [Short-term prognosis and risk factors of ventricular septal rupture following acute myocardial infarction].
abstract: OBJECTIVE
  To analyze the short-term prognosis and risk factors of ventricular septal rupture (VSR) following acute myocardial infarction (AMI).
  
  
  METHODS
  A total of 70 consecutive VSR patients following AMI hospitalized in our hospital from January 2002 to October 2010 were enrolled in this study. We compared the clinical characteristics of patients with VSR who survived ≤ 30 days (n = 39) and survived > 30 days (n = 31) post AMI. A short-term prognosis index of VSR (SPIV) was established based on the logistic regression analysis.
  
  
  RESULTS
  The single factor analysis showed that the risk factors of death within 30 days of VSR patients were female, anterior AMI, Killip class 3 or 4, apical VSR and non-aneurysm (all P < 0.05). Logistic regression analysis revealed that female (P = 0.013), anterior AMI (P = 0.023), non-aneurysm (P = 0.023), non-diabetes (P = 0.009), Killip class 3 or 4 (P = 0.022) and time from AMI to VSR less than 4 days (P = 0.027) were independent risk determinants for death within 30 days post VSR. Patients with SPIV ≥ 9 were associated with high risk [77.4% (24/31)] of dying within 30 days post AMI. SPIV ≤ 8 were associated with low risk as the 30 days mortality is 28.6% (8/28).
  
  
  CONCLUSIONS
  Female gender, anterior AMI, non-aneurysm, non-diabetes, Killip class 3 or 4 and time from AMI to VSR less than 4 days are independent risk factors of short-term mortality of VSR.
authors.affiliation: Coronary Heart Disease Center, Cardiovascular Institute and Fuwai Hospital, China Academy Medical Science and Peking Union Medical College, Beijing 100037, China.
authors.forename: Xiao-ying
authors.initials: XY
authors.lastname: Hu
authors.forename: Hong
authors.initials: H
authors.lastname: Qiu
authors.forename: Shu-bin
authors.initials: SB
authors.lastname: Qiao
authors.forename: Lian-ming
authors.initials: LM
authors.lastname: Kang
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Tan
authors.forename: Shao-dong
authors.initials: SD
authors.lastname: Ye
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wu
authors.forename: Guo-gan
authors.initials: GG
authors.lastname: Wang
authors.forename: Yue-jin
authors.initials: YJ
authors.lastname: Yang
authors.forename: Run-lin
authors.initials: RL
authors.lastname: Gao
authors.forename: Zai-jia
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D018658:Ventricular Septal Rupture / Q000209:etiology*