title: Unilateral permanent loss of vision after nefopam administration.
abstract: Acute glaucoma angle closure is a rare complication of anaesthesia and multimodal analgesia. However it is a medical emergency, hence any delay in its treatment may have catastrophic consequences. We present a case of postoperative glaucoma, which had evolved to permanent blindness. We also reviewed the French pharmacovigilance database between 1996 and 2006 and found four other cases of acute glaucoma angle closure in postoperative period possibly related to the administration of nefopam.
authors.affiliation: Department of anaesthesia and intensive care medicine, hospital university of Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France.
authors.forename: G
authors.initials: G
authors.lastname: Corbonnois
authors.forename: G
authors.initials: G
authors.lastname: Iohom
authors.forename: C
authors.initials: C
authors.lastname: Lazarescu
authors.forename: I
authors.initials: I
authors.lastname: Hubert
authors.forename: H
authors.initials: H
authors.lastname: Bouaziz
mesh_terms: D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000768:Anesthesia, General; D019645:Arthroplasty, Replacement, Knee; D001766:Blindness / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced; D006801:Humans; D009340:Nefopam / Q000009:adverse effects*; D009407:Nerve Block; D009901:Optic Nerve Diseases / Q000139:chemically induced; D010147:Pain Measurement; D010149:Postoperative Pain / Q000150:complications / Q000188:drug therapy; D011183:Postoperative Complications / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D018712:Analgesics, Non-Narcotic; D009340:Nefopam
keywords: Analgesics non-opioid-nefopam; Analgésie; Complication; Complications; Néfopam; Postoperative analgesia; Postopératoire