title: [Influence of beta-endorphin on the proliferative and phagocytic activity of peripheral blood cells from males and females in different age groups].
abstract: It was revealed that beta-endorphin modulation of lymphocyte proliferative activity in male donors was predominantly observed under younger age groups of 20-29 and 30-39 years, while with age it gradually decreased and disappeared as such in group of donors under 50-60 years. Meanwhile, females demonstrated prolonged modulating effect of peptide on the proliferation. In female group under 50-59 years the peptide was found to render marked promoting effect on the spontaneous proliferation in concentrations of 10(-7), 10(-8), and 10(-10) M that was induced by suboptimal PHA concentration of 10(-10) M, whereas women in the range of 30-39 years showed that beta-endorphin suppressed the PHA-induced proliferative response. Male donors in age group of 20-29 years demonstrated beta-endorphin-stimulated and in age group of 50-59 years beta-endorphin-suppressed uptake capacity of neutrophils. In female donors from all age groups the effect of beta-endorphin on neutrophil phagocyte activity was not observed.
authors.forename: S V
authors.initials: SV
authors.lastname: Geĭn
authors.forename: S G
authors.initials: SG
authors.lastname: Gileva
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism*; D010587:Phagocytosis / Q000187:drug effects* / Q000502:physiology; D010835:Phytohemagglutinins / Q000494:pharmacology; D012727:Sex Characteristics; D001615:beta-Endorphin / Q000494:pharmacology*
chemical_list: D008934:Mitogens; D010835:Phytohemagglutinins; D001615:beta-Endorphin