title: Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues.
abstract: HOTAIR is a known long non-coding RNA which has recently been associated with the progression of some cancer types. It has been reported that HOTAIR expression is correlated with SUZ12 expression level and therefore may affect the epigenetic state of cancer tissues. Here, we found aberrant up-regulation of HOTAIR in gastric adenocarcinoma samples compared with normal adjacent gastric epithelium tissues. Besides, we found that the aberrant expression of HOTAIR was associated with TNM staging and lymph node metastasis of gastric tumors. Here, a potential cooperative expression between HOTAIR and SUZ12 genes in gastric adenocarcinoma tissues is deduced. This result suggests a role for HOTAIR long non-coding RNA in gastric cancer progression.
authors.affiliation: Department of Genetics, School of Biological Sciences, Tarbiat Modares University, P.O. Box 14115-154, Tehran, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Hajjari
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Behmanesh
authors.forename: Majid
authors.initials: M
authors.lastname: Sadeghizadeh
authors.forename: Mehdi
authors.initials: M
authors.lastname: Zeinoddini
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D063151:Polycomb Repressive Complex 2 / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D014157:Transcription Factors; D015854:Up-Regulation / Q000235:genetics*
chemical_list: C561566:HOTAIR long untranslated RNA, human; D009363:Neoplasm Proteins; D062085:RNA, Long Noncoding; C430461:SUZ12 protein, human; D014157:Transcription Factors; D063151:Polycomb Repressive Complex 2