title: One-step synthesis of an organic-inorganic hybrid boronate affinity monolithic column with synergistic co-monomers.
abstract: An organic-inorganic hybrid and synergistic boronate affinity (BA) monolithic column was synthesized by a novel "one-step" approach. We report on the synthesis of a unique organic-inorganic hybrid affinity monolith by using TEOS, the organic silane, N-(β-aminoethyl)-γ-aminopropyltriethoxysilane (AEAPTES) and γ-MAPS as the co-precursors, 4-vinylphenylboronic acid as the functionalized monomer, and azobisisobutyronitrile (AIBN) as the initiator. Due to the presence of amino groups in the AEAPTES molecule, the prepared monolith exhibits several attractive properties. The monolith will be more hydrophilic and can bind with cis-diol compounds at neutral pH by a mechanism of intermolecular B-N coordination. The resulting hybrid boronate affinity monoliths have potential applications in specific recognition and enrichment of cis-diol biomolecules under neutral conditions.
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Dihui
authors.initials: D
authors.lastname: Huang
authors.forename: Shanxia
authors.initials: S
authors.lastname: Jin
authors.forename: Hailong
authors.initials: H
authors.lastname: Zhou
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
mesh_terms: D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D002853:Chromatography, Liquid / Q000379:methods*; D012821:Silanes / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D012821:Silanes