title: Resistance in tuberculosis: what do we know and where can we go?
abstract: Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms.
authors.affiliation: Department of Pharmaceutical Sciences, University of Kentucky Lexington, KY, USA.
authors.forename: Keith D
authors.initials: KD
authors.lastname: Green
authors.forename: Sylvie
authors.initials: S
authors.lastname: Garneau-Tsodikova
keywords: antibiotics; inhibitors; mechanisms of resistance; new drug targets; synergistic drug therapy