title: Pathological ventricular remodeling: mechanisms: part 1 of 2.
abstract: Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.
authors.affiliation: Texas Heart Institute, Houston, TX, USA.
authors.forename: Jana S
authors.initials: JS
authors.lastname: Burchfield
authors.forename: Min
authors.initials: M
authors.lastname: Xie
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hill
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D018450:Disease Progression; D006333:Heart Failure / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D009206:Myocardium / Q000473:pathology; D020257:Ventricular Remodeling / Q000502:physiology*
keywords: cardiac electrophysiology; fibrosis; inflammation; stem cells; ventricular remodeling