title: Direct N-cyclopropylation of secondary acyclic amides promoted by copper.
abstract: The N-cyclopropylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper system. The corresponding tertiary acyclic amides, which constitute a wide family of biologically active compounds, have been obtained in good to excellent yields.
authors.affiliation: CNRS, UMR 5253, Institut Charles Gerhardt Montpellier AM2N, ENSCM, 8, rue de l'Ecole Normale, 34296 Montpellier Cedex 5, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Racine
authors.forename: Florian
authors.initials: F
authors.lastname: Monnier
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vors
authors.forename: Marc
authors.initials: M
authors.lastname: Taillefer
mesh_terms: D000577:Amides / Q000737:chemistry*; D000813:Anilides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization
chemical_list: D000577:Amides; D000813:Anilides; D003300:Copper; C034595:benzanilide