title: [The clinical value of autofluorescence bronchoscopy for precancerous lesions in operable primary lung cancer patients].
abstract: BACKGROUND
  The aim of the present study is to show the role of autofluorescence bronchoscopy (AFB) compare with white light bronchoscopy (WLB) in detecting synchronous cancer and precancerous lesions in cases with operable primary lung cancer.
  
  
  METHODS
  Fourty-nine patients were included in the study. WLB findings were grouped as group 1 normal, group 2 erithema or edema, group 3 nodular lesions or mucosal abnormality. AFB findings were grouped as group 1 normal, group 2 light brownish abnormal areas, group 3 brownish abnormal areas. Biopsies were obtained from group 2 and 3 patients. In 12 (24.5%) of the patients no areas were suspected and no biopsies were taken.
  
  
  RESULTS
  Twenty-six (53%) of 49 patients did not show abnormal biopsy results in any of the specimens. One (2%) patient had metaplasia, 1 (2%) patient had dysplasia, 1 (2%) patient had in situ carcinoma. The diagnostic accuracy rates for the detection of synchronous cancer and precancerous lesions using WLB and AFB were as follows respectively: sensitivity 77.8% vs. 100%; specificity 37.5% vs. 3%; positive predictive value 21.9% vs. 24.3%; negative predictive value 88.2% vs. 100%. The relative sensitivity of AFB to WLB is 1.28.
  
  
  CONCLUSIONS
  This study demonstrated that, AFB is an effective method in detecting synchronous cancer and precancerous lesions because of its low specificity it is more likely to be complementary to WLB.
authors.affiliation: Clinic of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey. drburcuayigitbas@yahoo.com
authors.forename: Burcu
authors.initials: B
authors.lastname: Arpınar Yiğitbaş
authors.forename: Sibel
authors.initials: S
authors.lastname: Yurt
authors.forename: Ayşe Filiz
authors.initials: AF
authors.lastname: Arpaçağ Koşar
authors.forename: Nevin
authors.initials: N
authors.lastname: Işık
authors.forename: Evren
authors.initials: E
authors.lastname: Canel Karakaş
authors.forename: Hatice
authors.initials: H
authors.lastname: Kutbay Özçelik
authors.forename: Nur
authors.initials: N
authors.lastname: Ürer
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001999:Bronchoscopy / Q000379:methods*; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005453:Fluorescence; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000473:pathology; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology; D012680:Sensitivity and Specificity