title: Enhanced solubility and modified release of poorly water-soluble drugs via self-assembled gelatin-oleic acid nanoparticles.
abstract: Recently, we synthesized novel amphiphilic gelatin-oleic acid (GO) conjugate to prepare self-assembled nanoparticles for drug delivery. The aim of this study was to investigate pharmaceutical potentialities of self-assembled GO nanoparticles for solubility enhancement and modified release of poorly water-soluble drugs. Three poorly water-soluble model drugs with different pH-dependent solubility (valsartan and aceclofenac, insoluble at pH 1.2; telmisartan, insoluble at pH 6.8) were chosen to investigate the potential contributions of self-assembled GO nanoparticles to solubility enhancement and controlled release. The particle size of the drug-loaded nanoparticles was 200-250 nm. Zeta potential was calculated, and instrumental analysis such as powder X-ray diffraction (PXRD) and Fourier transform infrared (FT-IR) spectroscopy were used to investigate the physicochemical properties of the drug-loaded nanoparticles. Compared to the drug alone, the drug-loaded nanoparticles showed enhanced solubility. Furthermore, the release profiles of the model drugs were modified in a controlled manner. The current self-assembled GO nanoparticles can provide a versatile potential in drug delivery and tumor targeting.
authors.affiliation: International University, Vietnam National University - Ho Chi Minh City, Viet Nam.
authors.forename: Phuong Ha-Lien
authors.initials: PH
authors.lastname: Tran
authors.forename: Thao Truong-Dinh
authors.initials: TT
authors.lastname: Tran
authors.forename: Beom-Jin
authors.initials: BJ
authors.lastname: Lee
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry; D001565:Benzoates / Q000737:chemistry; D004008:Diclofenac / Q000031:analogs & derivatives / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry*; D010316:Particle Size; D033362:Powder Diffraction; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D000077333:Telmisartan; D013777:Tetrazoles / Q000737:chemistry; D014633:Valine / Q000031:analogs & derivatives / Q000737:chemistry; D000068756:Valsartan; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001562:Benzimidazoles; D001565:Benzoates; D013777:Tetrazoles; D014867:Water; D004008:Diclofenac; D019301:Oleic Acid; D000068756:Valsartan; D005780:Gelatin; D014633:Valine; C056498:aceclofenac; D000077333:Telmisartan
keywords: Enhanced solubility; Gelatin–oleic acid conjugate; Modified release; Poorly water-soluble drugs; Self-assembled nanoparticles; pH-dependent solubility