title: [Clinical benefit of full-dose gemcitabine for advanced pancreatic cancer refractory to S-1+gemcitabine].
abstract: A 62-year-old man with pancreatic body cancer underwent distal pancreatectomy without adjuvant gemcitabine(GEM). Because the pancreatic cancer recurred 4 months after surgery, however, he was treated with combination chemotherapy(S- 1+GEM at 750mg/m2). Unfortunately, this combination regimen was ineffective; therefore S-1 was withdrawn and full-dose GEM was administered as second-line treatment. One year of full-dose GEM showed a significant clinical benefit, completely eliminating multiple pulmonary metastases even after a 3-month suspension of chemotherapy. Our findings suggest that GEM monotherapy is a useful mainstream treatment for advanced pancreatic cancer.
authors.affiliation: Dept. of Surgery, Tachikawasougo Hospital, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hachisuka
authors.forename: Masaya
authors.initials: M
authors.lastname: Takahashi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kushima
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nakamoto
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yachiyo
authors.initials: Y
authors.lastname: Iwamura
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Wakata
authors.forename: Kayoko
authors.initials: K
authors.lastname: Nagano
authors.forename: Takuya
authors.initials: T
authors.lastname: Nakajima
authors.forename: Maki
authors.initials: M
authors.lastname: Nunomura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Araki
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D000093542:Gemcitabine
chemical_list: D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine