title: Cyathula prostrata: a potent source of anticancer agent against daltons ascites in Swiss albino mice.
abstract: OBJECTIVE
  To evaluate the anticancer activity of the methanolic extract of Cyathula prostrata in Ehrlich ascites carcinoma (EAC)-bearing mice with methotrexate as positive control in the advanced stage of tumorigenesis.
  
  
  METHODS
  EAC was induced in swiss albino mice by injecting 10(6) cell/mL of tumor cell suspension intraperitoneal. The methanolic extract of Cyathula prostrata effect on the tumor cell viability, DNA fragmentation and MTT assay were carried out.
  
  
  RESULTS
  Methanolic extract attenuated percentage increased in the cell survival time when compared to control group. However, the effect was less than that of methotrexat. Methotrexat and the extracts reversed the tumor-induced alterations in DNA fragmentation and MTT assay.
  
  
  CONCLUSIONS
  The present study suggests that the methanol extract of Cyathula prostrata has significant anticancer activity and that is comparable to that of methotrexate.
authors.affiliation: PSG College of Arts and Science, Coimbatore, Tamilnadu, India-641014. priyak08@gmail.com
authors.forename: K
authors.initials: K
authors.lastname: Priya
authors.forename: S
authors.initials: S
authors.lastname: Krishnakumari
authors.forename: M
authors.initials: M
authors.lastname: Vijayakumar
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D053938:DNA Fragmentation / Q000187:drug effects; D005260:Female; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Antitumor; Cancer; Cyathula prostrata; Ehrlich ascites carcinoma; MTT