title: Nutritional rickets: pathogenesis and prevention.
abstract: Nutritional rickets remains a public health concern in many areas of the world despite cheap and effective means of preventing the disease. The roles of vitamin D deficiency, low dietary calcium intakes and the interrelationships between the two in the pathogenesis of the disease are discussed. It is now recognized that vitamin D deficiency in the pregnant and lactating mother predisposes to the development of rickets in the breastfed infant, and that cultural and social factors are important in the pathogenesis of the disease during the adolescent growth spurt. Prevention of rickets is dependent on the awareness of the medical profession and the general public of the need to ensure adequate intakes of vitamin D in at-risk populations, and of the importance of increasing dietary intakes of calcium using locally available and inexpensive foods in communities in which dietary calcium deficiency rickets is prevalent.
authors.affiliation: MRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. John.pettifor@wits.ac.za
authors.forename: John M
authors.initials: JM
authors.lastname: Pettifor
mesh_terms: D001942:Breast Feeding; D002118:Calcium / Q000172:deficiency*; D002136:Calcium, Dietary / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D011247:Pregnancy; D012279:Rickets / Q000209:etiology* / Q000517:prevention & control; D014807:Vitamin D / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000628:therapy*
chemical_list: D002136:Calcium, Dietary; D014807:Vitamin D; D002118:Calcium