title: Pulsatile and steady-state hemodynamics of the human patella bone by diffuse optical spectroscopy.
abstract: The cardiac cycle related pulsatile behavior of the absorption and scattering coefficients of diffuse light and the corresponding alterations in hemoglobin concentrations in the human patella was studied. The pulsations in scattering is considerably smaller than absorption. The difference in amplitude of absorption coefficient pulsations for different wavelengths was translated to pulsations in oxygenated and deoxygenated hemoglobin, which leads to strong pulsations in the total hemoglobin concentration and oxygen saturation. The physiological origin of the observed signals was confirmed by applying a thigh-cuff. Moreover, we have investigated the optical and physiological properties of the patella bone and their changes in response to arterial cuff occlusion.
authors.affiliation: ICFO-Institut de Ciències Fotòniques, Mediterranean Technology Park, 08860, Castelldefels Barcelona, Spain. parisa.farzam@icfo.es
authors.forename: Parisa
authors.initials: P
authors.lastname: Farzam
authors.forename: Peyman
authors.initials: P
authors.lastname: Zirak
authors.forename: Tiziano
authors.initials: T
authors.lastname: Binzoni
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
mesh_terms: D000328:Adult; D001158:Arteries / Q000502:physiology; D003198:Computer Simulation; D004058:Diffusion; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007717:Knee / Q000098:blood supply; D008297:Male; D055620:Optical Phenomena; D010100:Oxygen / Q000378:metabolism; D010329:Patella / Q000098:blood supply*; D011673:Pulsatile Flow / Q000502:physiology*; D012146:Rest; D019265:Spectroscopy, Near-Infrared
chemical_list: D006454:Hemoglobins; D010100:Oxygen