title: A Novel Glycinate-based Body Wash: Clinical Investigation Into Ultra-mildness, Effective Conditioning, and Improved Consumer Benefits.
abstract: OBJECTIVE
  To assess the properties of a novel body wash containing the mild surfactant glycinate.
  
  
  METHODS
  Biochemical and clinical assays.
  
  
  METHODS
  Research laboratories and clinical sites in the United States and Canada.
  
  
  METHODS
  Women 18 to 65 years of age (cleansing efficacy); male and female subjects 26 to 63 years of age with mild or moderate dryness and erythema (leg-controlled application test); subjects 5 to 65 years of age with mild-to-moderate eczema (eczema compatibility); and women 18 to 64 years of age (home use).
  
  
  METHODS
  Assessments across studies included colorimetric dye exclusion to assess skin damage potential (corneosurfametry), efficacy of cosmetic product removal from skin, change from baseline in visual dryness, change from baseline in Eczema Area and Severity Index, and self-perceived eczema attributes and self-reported product preference.
  
  
  RESULTS
  The glycinate-based cleanser demonstrated mildness to skin components when evaluated in a corneosurfametry assay. Short-term use under exaggerated wash conditions in subjects with dryness scores <3 and erythema scores <2 (both on a 0-6 scale) indicated an initial reduction in visual dryness. In subjects with eczema, normal use resulted in significant improvements (p<0.05) at Week 4 compared with baseline in skin dryness (change from baseline = -0.73), rash (-0.56), itch (-0.927), tightness (-0.585), and all eczema (-0.756). The glycinate-based body wash removed 56 percent of a long-lasting cosmetic foundation from skin compared with less than 30 percent removed by two competitive products tested. The glycinate-based body wash was preferred over a competitive mild cleansing product overall.
  
  
  CONCLUSIONS
  The patented glycinate-containing body wash demonstrated better product mildness and patient-preferred attributes and clinical benefits.
authors.affiliation: Unilever Global Skin Claims, Trumbull, Connecticut.
authors.forename: Jamie
authors.initials: J
authors.lastname: Regan
authors.forename: Leonel-Maximo
authors.initials: LM
authors.lastname: Mollica
authors.forename: K P
authors.initials: KP
authors.lastname: Ananthapadmanabhan