title: [Regulatory lymphocytes: a new cooperation between T and B cells for a better control of the immune response].
abstract: Mechanims of peripheral tolerance include molecular controls and the presence of regulatory lymphocytes. Regulatory T lymphocytes (Tregs) correspond to different sub-populations of T cells that control immune responses due to the production of cytokines, such as IL-10 and with direct cell-to-cell contacts. Tregs targets are antigen presenting cells, such as dendritic cells, effector CD4(+) and CD8(+) lymphocytes but also effector antibody-producing B lymphocytes. Regulatory B lymphocytes (Bregs) have been more recently described and likely represent different sub-populations of B cells that control the development of autoimmune and inflammatory diseases due to the production of IL-10 and using intercellular contacts. Bregs targets encompass all the cells involved in the immune responses which are thus under a dual control by regulatory lymphocytes. Development and efficient activity of Tregs appear dependent of Bregs for a better regulation of autoimmune reactions, of anti-infectious reactions, but also of anti-tumor reactions.
authors.affiliation: Centre hospitalier regional universitaire, université européenne de Bretagne, université de Bretagne Occidentale, Brest, France. Electronic address: christophe.jamin@univ-brest.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Jamin
authors.affiliation: Centre hospitalier regional universitaire, université européenne de Bretagne, université de Bretagne Occidentale, Brest, France.
authors.forename: Achouak
authors.initials: A
authors.lastname: Achour
authors.affiliation: Centre hospitalier regional universitaire, université européenne de Bretagne, université de Bretagne Occidentale, Brest, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Youinou
authors.affiliation: Centre hospitalier regional universitaire, université européenne de Bretagne, université de Bretagne Occidentale, Brest, France.
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Pers
mesh_terms: D060151:B-Lymphocytes, Regulatory / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*