title: Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population.
abstract: A recent genome-wide association study (GWAS) identified new susceptibility single-nucleotide polymorphisms (SNPs) rs13361707 (PRKAA1 and PTGER4 gene on 5p13.1) and rs9841504 (ZBTB20 gene on 3q13.31) that were significantly associated with non-cardia gastric cancer. The aim of this study was to determine whether rs13361707 and rs9841504 polymorphisms are associated with the risk of gastric cancer in a Korean population. We conducted a large-scale case-control study of 3245 gastric cancer patients and 1700 controls. The allele frequencies for rs13361707 C and rs9841504 G were 53.5% and 18.3% among gastric cancer cases, compared with 47.1% and 17.2% among controls, respectively. We found that rs13361707 TC and CC genotypes were associated with increased risk for gastric cancer (odds ratios [OR] = 1.29; 95% confidence interval [CI] = 1.11-1.51 for TC vs. TT and 1.68; 1.41-2.01 for CC vs. TT). However, we found no significant association between rs9841504 and gastric cancer risk (OR = 1.11; 0.97-1.28 for CG vs. CC; OR = 1.09; 0.77-1.53 for GG vs. CC). We observed no significant interactions between rs13361707 and rs9841504 polymorphisms and age, gender, smoking habit, alcohol consumption, and clinicopathologic characteristics such as anatomical tumor location and histological type. Our study showed that the rs13361707 polymorphism was associated with increased risk of gastric cancer in a Korean population. This finding provides further evidence that genetic variant of PRKAA1 and PTGER4 genes may contribute to the gastric carcinogenesis. However, we found no association between rs9841504 and gastric cancer risk.
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Song
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Kim
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Shim
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Cho
authors.forename: Ik Joo
authors.initials: IJ
authors.lastname: Chung
authors.forename: Young-Kyu
authors.initials: YK
authors.lastname: Park
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Yoo-Duk
authors.initials: YD
authors.lastname: Choi
authors.forename: Kyung Woong
authors.initials: KW
authors.lastname: Joo
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology*; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; C427486:ZBTB20 protein, human; D055372:AMP-Activated Protein Kinases; C526180:PRKAA1 protein, human
keywords: PRKAA1; PTGER4; ZBTB20; gastric cancer; polymorphism