title: Minocycline influences the anti-inflammatory interleukins and enhances the effectiveness of morphine under mice diabetic neuropathy.
abstract: A single streptozotocin (STZ) injection in mice can induce significant neuropathic pain along with an increase in plasma glucose levels and a decrease in body weight. Seven days after the administration of STZ, an upregulation of C1q-positive cells was observed. Additionally, interleukins (IL-1beta, IL-3, IL-4, IL-6, IL-9, IL12p70, IL-17); proteins of the tumor necrosis factor (TNF) family, e.g., IFNgamma and sTNF RII, were upregulated. Chronic administration of minocycline increases antinociceptive factors (IL-1alpha, IL-2, IL-10, sTNFRII) in diabetic mice. Minocycline also reduces the occurrence of neuropathic pain and significantly potentiates the antiallodynic and antihyperalgesic effects of morphine.
authors.affiliation: Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zychowska
authors.forename: Ewelina
authors.initials: E
authors.lastname: Rojewska
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kreiner
authors.forename: Irena
authors.initials: I
authors.lastname: Nalepa
authors.forename: Barbara
authors.initials: B
authors.lastname: Przewlocka
authors.forename: Joanna
authors.initials: J
authors.lastname: Mika
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D003929:Diabetic Neuropathies / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D018836:Inflammation Mediators / Q000502:physiology*; D007378:Interleukins / Q000145:classification / Q000502:physiology*; D008297:Male; D051379:Mice; D008911:Minocycline / Q000008:administration & dosage* / Q000627:therapeutic use; D009020:Morphine / Q000494:pharmacology*; D009437:Neuralgia / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D015854:Up-Regulation / Q000276:immunology
chemical_list: D000701:Analgesics, Opioid; D018836:Inflammation Mediators; D007378:Interleukins; D009020:Morphine; D008911:Minocycline
keywords: Antibody array; Cytokines; Diabetic neuropathic pain; Microglia; Minocycline; Morphine