title: Microalbuminuria and glomerular filtration rate in paediatric visceral leishmaniasis.
abstract: Visceral leishmaniasis, caused by Leishmania donovani, is a serious form of leishmaniasis and fatal if untreated. Nearly half of the VL cases are children. There are very few studies of renal function in pediatric visceral leishmaniasis. The aim of this study was to evaluate renal dysfunction by studying glomerular filtration rate (GFR), microalbuminuria, and microscopic examination of urine. Laboratory analysis was performed on blood and urine samples of 40 parasitologically confirmed pediatric VL cases. Laboratory data of urine examination showed albuminuria in 10% (4/40), white blood cells in 20% (8/40), hematuria in 10% (4/40), microalbuminuria in 37.5% (15/40), and decreased GFR in 27.5% (11/40). Renal involvement was manifested in most of the pediatric VL cases. These findings may help clinicians in decision making for safe and suitable antileishmanial treatment particularly in childhood VL.
authors.affiliation: Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agam Kuan, Patna 800 007, India.
authors.forename: Neena
authors.initials: N
authors.lastname: Verma
authors.forename: Chandra Shekhar
authors.initials: CS
authors.lastname: Lal
authors.forename: Vidyanand
authors.initials: V
authors.lastname: Rabidas
authors.forename: Krishna
authors.initials: K
authors.lastname: Pandey
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Singh
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kumar
authors.forename: Rakesh Bihari
authors.initials: RB
authors.lastname: Verma
authors.forename: Pradeep
authors.initials: P
authors.lastname: Das
mesh_terms: D000419:Albuminuria / Q000150:complications* / Q000473:pathology / Q000503:physiopathology* / Q000652:urine; D002648:Child; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000150:complications* / Q000473:pathology / Q000503:physiopathology* / Q000652:urine