title: [Preparation of dealcholized onetaxotere®, docetaxel injection formulation and its pharmacokinetics in rats].
abstract: Onetaxotere®(OTAX)injection, which is a docetaxel(DOC)injection formulation, cannot be administered to those patients with alcohol intolerance or hypersensitivity, because it contains ethanol as a dissolving agent. To broaden treatment options for those patients, we tried to eliminate ethanol from OTAX injection. Under sterile conditions, dealcoholization was carried out using nitrogen gas in a hot water bath at 50°C. By this method, the ethanol included in OTAX injection was almost completely removed and DOC in the formulation was stable for 28 days. When the dealcoholized or untreated OTAX injection was intravenously injected in rats, no significant differences in the pharmacokinetic parameters of DOC were observed between those with dealcoholized and untreated OTAX injections. It is expected that dealcoholized OTAX may be useful in patients with alcohol-related difficulties.
authors.affiliation: Dept. of Pharmaceutics, Faculty of Pharmacy, Meijo University.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Onishi
authors.forename: Ikuto
authors.initials: I
authors.lastname: Tsukiyama
authors.forename: Miki
authors.initials: M
authors.lastname: Katoh
authors.forename: Jun
authors.initials: J
authors.lastname: Ueyama
authors.forename: Fumie
authors.initials: F
authors.lastname: Abe
authors.forename: Hiroko
authors.initials: H
authors.lastname: Saito
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Matsuura
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nadai
mesh_terms: D000818:Animals; D000077143:Docetaxel; D004304:Dosage Forms; D004355:Drug Stability; D000431:Ethanol; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D043823:Taxoids / Q000008:administration & dosage / Q000097:blood* / Q000737:chemistry
chemical_list: D004304:Dosage Forms; D043823:Taxoids; D000077143:Docetaxel; D000431:Ethanol