title: A dual location stimuli-responsive degradation strategy of block copolymer nanocarriers for accelerated release.
abstract: A new strategy that centers on the incorporation of stimuli-responsive cleavable linkages in dual or multiple locations as in both micellar cores and at polymer/solution interfaces leading to synergistically enhanced release of encapsulated anticancer drugs in cancer cells.
authors.affiliation: Department of Chemistry and Biochemistry, Concordia University, Montreal, Quebec, Canada H4B 1R6.
authors.forename: Nicky
authors.initials: N
authors.lastname: Chan
authors.forename: Behnoush
authors.initials: B
authors.lastname: Khorsand
authors.forename: Samuel
authors.initials: S
authors.lastname: Aleksanian
authors.forename: Jung Kwon
authors.initials: JK
authors.lastname: Oh
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008823:Micelles; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D004317:Doxorubicin