title: Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer.
abstract: Sirtuin-3 (SIRT3) was immunostained in 94 samples of esophageal cancer tissues and semiquantified using the HSCORE method to evaluate the predictive value of SIRT3 expression levels on esophageal cancer outcome. The relationship between SIRT3 expression and the 5-year survival rate of postoperational esophageal cancer patients was assessed with the Kaplan-Meier method. High expression of SIRT3 is associated with a shorter survival time in esophageal cancer patients, as shown by the log-rank test (P = .007), and the level of SIRT3 expression was identified as an independent predictor for esophageal cancer outcome using Cox proportional hazards model analysis (relative risk, 2.061; 95% confidence interval, 1.050-4.046; P = .036). SIRT3 expression was associated with esophageal cancer outcome. The analysis of SIRT3 levels can help in the identification of patient subgroups that are at high risk for poor disease outcomes.
authors.affiliation: Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Huichai
authors.initials: H
authors.lastname: Yang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Wang
authors.forename: Ruixing
authors.initials: R
authors.lastname: Zhang
authors.forename: Cuiju
authors.initials: C
authors.lastname: Wang
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Guo
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D056566:Sirtuin 3 / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C466093:SIRT3 protein, human; D056566:Sirtuin 3
keywords: Esophageal cancer; Predictor; SIRT3; Survival