title: Polymethylmethacrylate dermal fillers: evaluation of the systemic toxicity in rats.
abstract: This study evaluated local and systemic reactions after an intravascular injection of polymethylmethacrylate (PMMA) at two concentrations in a murine model. Thirty rats were divided equally into three groups: 2% PMMA, 30% PMMA, and a control group (normal saline only injection). The filler was injected into the ranine vein. The rats were sedated at 7 and 90 days and a clinical evaluation performed. After euthanasia, the right lung, liver, and right kidney were removed, weighed, and microscopically analyzed. The submandibular lymph nodes and tongue were removed and examined microscopically. Serum was subjected to liver and kidney function tests. No groups showed clinical alterations. Microspheres were not observed at any distant organ. Two samples from the 2% PMMA group showed a local inflammatory response at day 7 and another two samples from the 30% PMMA group at day 90. The group injected with 30% PMMA presented higher levels of alanine aminotransferase (P = 0.047) after 90 days when compared with the other groups. The data obtained in this study demonstrate that intravascular injections of PMMA fillers show potential health risks such as chronic inflammation at the implantation site.
authors.affiliation: Division of Oral Medicine, PUCRS, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: clarissacgmedeiros@yahoo.com.br.
authors.forename: C C G
authors.initials: CC
authors.lastname: Medeiros
authors.affiliation: Division of Oral Medicine, PUCRS, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: R L
authors.initials: RL
authors.lastname: Borghetti
authors.affiliation: Postgraduate Program of Cellular and Molecular Biology, PUCRS, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: N
authors.initials: N
authors.lastname: Nicoletti
authors.affiliation: Division of Pathology, PUCRS, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: V D
authors.initials: VD
authors.lastname: da Silva
authors.affiliation: Division of Oral Medicine, PUCRS, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: K
authors.initials: K
authors.lastname: Cherubini
authors.affiliation: Division of Oral Medicine, PUCRS, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: F G
authors.initials: FG
authors.lastname: Salum
authors.affiliation: Division of Oral Medicine, PUCRS, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: M A Z
authors.initials: MA
authors.lastname: de Figueiredo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity; D003357:Cosmetic Techniques / Q000009:adverse effects*; D005260:Female; D005548:Foreign-Body Migration / Q000473:pathology*; D005549:Foreign-Body Reaction / Q000139:chemically induced* / Q000473:pathology; D007271:Injections, Intradermal; D019904:Polymethyl Methacrylate / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014059:Tongue
chemical_list: D001672:Biocompatible Materials; D019904:Polymethyl Methacrylate
keywords: adverse effects; oral medicine; polymethylmethacrylate; toxicology