title: Serum S100A12 levels are associated with the presence and severity of obstructive sleep apnea syndrome in male patients.
abstract: OBJECTIVE
  Inflammation plays a critical role in the pathogenesis of obstructive sleep apnea syndrome (OSAS). S100A12 is a newly identified inflammatory biomarker. This study aims to investigate whether serum S100A12 levels are associated with the presence and severity of OSAS in male patients.
  
  
  METHODS
  A total of 126 male patients with OSAS and 74 controls were enrolled in this study. The presence and severity of OSAS was assessed by apnea-hypopnea index (AHI). Serum S100A12 levels were detected by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum S100A12 levels were significantly higher in the OSAS group than in the control group (132.17 (range 101.86 to 174.49) ng/ml vs. 78.40 (range 58.35 to 129.44) ng/ml, P < 0.01). Multivariate logistic regression demonstrated that S100A12 was the only significant and independent predictor of OSAS (odds ratio 1.012, 95% confidence interval 1.006 to 1.017; P < 0.01). Serum S100A12 levels elevated with the increase in the severity of OSAS (S100A12 levels of 106.04 (range 83.92 to 135.13) ng/ml in mild OSAS group, 133.51 (range 109.64 to 208.95) ng/ml in moderate OSAS group, and 173.04 (range 131.88 to 275.77) ng/ml in severe OSAS group; P < 0.001). Serum S100A12 levels were independently correlated with AHI scores (r = 0.324, P < 0.001) CONCLUSIONS: Serum S100A12 levels were independently associated with the presence and severity of OSAS. These findings suggest that serum S100A12 level could be a potential biomarker for reflecting the presence and severity of OSAS.
authors.affiliation: Department of Emergency Medicine, Affiliated Hospital of Weifang Medical University, 465 Yuhe Road, 261031, Weifang, Shandong, People's Republic of China, wfshiyoukui@126.com.
authors.forename: You-kui
authors.initials: YK
authors.lastname: Shi
authors.forename: Jing-xia
authors.initials: JX
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Ai-ying
authors.initials: AY
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D009418:S100 Proteins / Q000097:blood*; D000067616:S100A12 Protein; D012737:Sex Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000145:classification / Q000175:diagnosis; D013223:Statistics as Topic
chemical_list: D018836:Inflammation Mediators; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human