title: Acute disseminated intravascular coagulation developed after dilation and curettage in an adenomyosis patient: a case report.
abstract: We reported a rare case of acute disseminated intravascular coagulation (DIC) after dilation and curettage in an adenomyosis and missed abortion patient. The clinical performance improved after treatment with tranexamic acid, blood transfusions and subtotal hysterectomy. Hemorrhage, degeneration and necrosis were found in the myometrium. Pregnancy-related thrombotic tendency, accelerated uterus tissue injury after curettage, activation of coagulation system, microthrombosis formation, myometrium necrosis, exhaustion of coagulation factors and hyperfibrinolysis might play the crucial roles in the pathophysiology of acute DIC. Physicians should be alert that adenomyosis patients undergoing dilation and curettage may be in danger of DIC.
authors.affiliation: aDepartment of Obstetrics and Gynecology bDepartment of Pathology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiong
authors.initials: X
authors.lastname: Xiao
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Luo
authors.forename: Gang
authors.initials: G
authors.lastname: Shi
authors.forename: Yanmei
authors.initials: Y
authors.lastname: He
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yao
authors.forename: Liangzhi
authors.initials: L
authors.lastname: Xu
mesh_terms: D062788:Adenomyosis / Q000601:surgery*; D000328:Adult; D004107:Dilatation and Curettage / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans