title: Gastroprotective effect of the aqueous leaf extract of Guiera senegalensis in Albino rats.
abstract: OBJECTIVE
  To evaluate the effect of aqueous leaf extract of Guiera senegalensis (G. senegalensis) on gastric mucosal damage using different ulcer models.
  
  
  METHODS
  Considering the above claims, the present study was undertaken to validate the gastroprotective potential of the aqueous leaf extract of this plant against ethanol, water immersion and Aspirin induced ulcer models.
  
  
  RESULTS
  The leaf extract (50, 100 and 200 mg/kg, p.o.) significantly (P<0.05) decreased the ulcer index in all assays used.
  
  
  CONCLUSIONS
  The results obtained, provide strong evidence of antiulcer activity of the leaf extract of G. senegalensis and support the traditional uses of the plant for the treatment of ulcer.
authors.affiliation: Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria. goddyakuodor@yahoo.com
authors.forename: G C
authors.initials: GC
authors.lastname: Akuodor
authors.forename: A D
authors.initials: AD
authors.lastname: Essien
authors.forename: E
authors.initials: E
authors.lastname: David-Oku
authors.forename: K C
authors.initials: KC
authors.lastname: Chilaka
authors.forename: J L
authors.initials: JL
authors.lastname: Akpan
authors.forename: B
authors.initials: B
authors.lastname: Ezeokpo
authors.forename: J O C
authors.initials: JO
authors.lastname: Ezeonwumelu
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D029764:Combretaceae / Q000737:chemistry*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts
keywords: Aqueous extract; Aspirin; Ethanol; Guiera senegalensis; Stress induced gastric ulcers