title: Neural effects of prolonged mental fatigue: a magnetoencephalography study.
abstract: Mental fatigue, manifest as a reduced efficiency for mental work load, is prevalent in modern society. It is important to understand the neural mechanisms of mental fatigue and to develop appropriate methods for evaluating mental fatigue. In this study we quantified the effect of a long-duration mental fatigue-inducing task on neural activity. We used magnetoencephalography (MEG) to examine the time course change of neural activity over the long duration of the task trials. Nine healthy male volunteers participated in this study. They performed two mental fatigue-inducing tasks on separate days. The order of task presentation was randomized in a single-blinded, crossover fashion. Each task consisted of 25-min mental fatigue-inducing 0- or 2-back task session for three times. Subjective rating of mental fatigue sensation and electrocardiogram, and resting state MEG measurements were performed just before and after each task session. MEG data were analyzed using narrow-band adaptive spatial filtering methods. Alpha band (8-13 Hz) power in the visual cortex decreased after performing the mental fatigue-inducing tasks, and the decrease of alpha power was greater when they performed 2-back task trials. The decrease in alpha power was positively associated with the self-reported level of mental fatigue sensation and sympathetic nerve activity level. These results demonstrate that performing the prolonged mental fatigue-inducing task causes overactivation of the visual cortex, manifest as decreased alpha power in this brain region. Our results increase understanding of the neural mechanisms of mental fatigue and can be used to develop new quantitative methods to assess mental fatigue.
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Osaka 545-8585, Japan. a.ishii@med.osaka-cu.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Ishii
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Shigihara
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kanai
authors.forename: Masami
authors.initials: M
authors.lastname: Funakura
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001683:Biological Clocks / Q000502:physiology; D004562:Electrocardiography; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D005222:Mental Fatigue / Q000473:pathology*; D008875:Middle Aged; D010147:Pain Measurement; D016037:Single-Blind Method; D013997:Time Factors; D014793:Visual Cortex / Q000503:physiopathology*
keywords: Adaptive spatial filtering; Long duration; Magnetoencephalography (MEG); Mental fatigue