title: Effect of Trichinella spiralis infection on the immune response to HBV vaccine in a mouse model.
abstract: Vaccination is the most effective and cost-effective way to treat hepatitis B virus (HBV) infection. Collective data suggest that helminth infections affect immune responses to some vaccines. Therefore, it is important to reveal the effects of helminth infections on the efficacy of protective vaccines in countries with highly prevalent helminth infections. In the present work, effects of Trichinella spiralis infection on the protective efficacy of HBV vaccine in a mouse model were investigated. This study demonstrated that the enteric stage of T. spiralis infection could inhibit the proliferative response of spleen lymphocytes to hepatitis B surface antigen (HBsAg) and lead to lower levels of anti-HBsAg antibodies, interferon-γ, and interleukin (IL)-2, along with higher levels of IL-4 and IL-5. However, these immunological differences are absent in the muscle stage of T. spiralis infection. The results suggest that the muscle stage of T. spiralis infection does not affect the immune response to HBV vaccination, while the enteric-stage infection results in a reduced immune response to HBsAg.
authors.affiliation: Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China .
authors.forename: Fei
authors.initials: F
authors.lastname: Guan
authors.forename: Xiao
authors.initials: X
authors.lastname: Hou
authors.forename: Ge
authors.initials: G
authors.lastname: Nie
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Wen-qi
authors.initials: WQ
authors.lastname: Liu
authors.forename: Yong-long
authors.initials: YL
authors.lastname: Li
authors.forename: Jia-hui
authors.initials: JH
authors.lastname: Lei
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology*; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D056724:Immunity, Humoral; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009132:Muscles / Q000469:parasitology; D013154:Spleen / Q000276:immunology; D017160:Trichinella spiralis / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology* / Q000469:parasitology; D014611:Vaccination
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D016207:Cytokines; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines