title: Mineral and trace element analysis of saliva from patients with BMS: a cross-sectional prospective controlled clinical study.
abstract: OBJECTIVE
  The aim of this study was to investigate salivary markers related to burning mouth syndrome (BMS).
  
  
  METHODS
  A cross-sectional prospective controlled clinical study of 58 patients (28 BMS and 30 control). The presence of mineral and trace metals in unstimulated whole saliva was analyzed in BMS patients and in control subjects by means of ICP-OES. The parameters analyzed were as follows: oral health-related quality of life (OHIP-14) and the Hospital Anxiety Depression (HAD) scale. A visual analogue scale (VAS) was used to measure the intensity of burning sensation (pain).
  
  
  RESULTS
  The mean pain value for patients with BMS was 7.8 ± 2.4. OHIP-14 oral health-related quality of life among BMS patients was found to be affected: total BMS OHIP-14 (16.98 ± 12.29) vs. control (8.53 ± 10.5) with significant difference (P = 0.015). Concentrations of the different elements were slightly higher among BMS patients but without statistically significant differences for any of the elements analyzed (Na, K, Ca, Mg, Fe, Cu, Mn, Zn, B, P, S, Al, Pb, Cd, Cr, Ni, As, Be, Bi, Co, Li, Mo, Sb, Se, Sr, Ti, Tl, V).
  
  
  CONCLUSIONS
  This study failed to identify abnormal levels of minerals or trace elements in saliva of patients with BMS.
authors.affiliation: Hospital Morales Meseguer, Clínica Odontologica Universitaria, Oral Medicine, Ageing Research Institute, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors.forename: Pía
authors.initials: P
authors.lastname: López-Jornet
authors.forename: Hermogenes
authors.initials: H
authors.lastname: Juan
authors.forename: Pons-Fuster
authors.initials: PF
authors.lastname: Alvaro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000523:psychology; D002054:Burning Mouth Syndrome / Q000378:metabolism* / Q000523:psychology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003863:Depression / Q000523:psychology; D005260:Female; D005926:Glossalgia / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000032:analysis*; D009909:Oral Health; D010147:Pain Measurement / Q000379:methods; D011446:Prospective Studies; D011788:Quality of Life; D012463:Saliva / Q000737:chemistry*; D013057:Spectrum Analysis; D014131:Trace Elements / Q000032:analysis*; D064232:Visual Analog Scale
chemical_list: D008903:Minerals; D014131:Trace Elements
keywords: OHIP; burning mouth syndrome; metals; saliva