title: Four decades of leading-edge research in the reproductive and developmental sciences: the Infant Primate Research Laboratory at the University of Washington National Primate Research Center.
abstract: The Infant Primate Research Laboratory (IPRL) was established in 1970 at the University of Washington as a visionary project of Dr. Gene (Jim) P. Sackett. Supported by a collaboration between the Washington National Primate Research Center and the Center on Human Development and Disability, the IPRL operates under the principle that learning more about the causes of abnormal development in macaque monkeys will provide important insights into the origins and treatment of childhood neurodevelopmental disabilities. Over the past 40 years, a broad range of research projects have been conducted at the IPRL. Some have described the expression of normative behaviors in nursery-reared macaques while others have focused on important biomedical themes in child health and development. This article details the unique scientific history of the IPRL and the contributions produced by research conducted in the laboratory. Past and present investigations have explored the topics of early rearing effects, low-birth-weight, prematurity, birth injury, epilepsy, prenatal neurotoxicant exposure, viral infection (pediatric HIV), diarrheal disease, vaccine safety, and assisted reproductive technologies. Data from these studies have helped advance our understanding of both risk and resiliency in primate development. New directions of research at the IPRL include the production of transgenic primate models using our embryonic stem cell-based technology to better understand and treat heritable forms of human intellectual disabilities such as fragile X.
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington; Center on Human Development and Disability, University of Washington, Seattle, Washington; Washington National Primate Research Center, University of Washington, Seattle, Washington.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Burbacher
authors.forename: Kimberly S
authors.initials: KS
authors.lastname: Grant
authors.forename: Julie
authors.initials: J
authors.lastname: Worlein
authors.forename: James
authors.initials: J
authors.lastname: Ha
authors.forename: Eliza
authors.initials: E
authors.lastname: Curnow
authors.forename: Sandra
authors.initials: S
authors.lastname: Juul
authors.forename: Gene P
authors.initials: GP
authors.lastname: Sackett
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000523:psychology; D001522:Behavior, Animal; D005260:Female; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008251:Macaca; D008297:Male; D008431:Maternal-Fetal Exchange; D023421:Models, Animal; D011247:Pregnancy; D011323:Primates; D012098:Reproduction; D012106:Research / Q000266:history*; D014495:Universities; D014861:Washington
keywords: Macaque; animal model; behavior; developmental disabilities; infant