title: One-pot synthesis of redox-responsive polymers-coated mesoporous silica nanoparticles and their controlled drug release.
abstract: A versatile one-pot strategy for the preparation of reversibly cross-linked polymer-coated mesoporous silica nanoparticles (MSNs) via surface reversible addition-fragmentation chain transfer (RAFT) polymerization is presented for the first time in this paper. The less reactive monomer oligo(ethylene glycol) acrylate (OEGA) and the more reactive cross-linker N,N'-cystaminebismethacrylamide (CBMA) are chosen to be copolymerized on the external surfaces of RAFT agent-functionalized MSNs to form the cross-linked polymer shells. Owing to the reversible cleavage and restoration of disulfide bonds via reduction/oxidation reactions, the polymer shells can control the on/off switching of the nanopores and regulate the drug loading and release. The redox-responsive release of doxorubicin (DOX) from this drug carrier is realized. The protein adsorption, in vitro cytotoxicity assays, and endocytosis studies demonstrate that this biocompatible vehicle is a potential candidate for delivering drugs. It is expected that this versatile grafting strategy may help fabricate satisfying MSN-based drug delivery systems for clinical application.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, PR China.
authors.forename: Jiao-Tong
authors.initials: JT
authors.lastname: Sun
authors.forename: Ji-Gang
authors.initials: JG
authors.lastname: Piao
authors.forename: Long-Hai
authors.initials: LH
authors.lastname: Wang
authors.forename: Mohsin
authors.initials: M
authors.lastname: Javed
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Hong
authors.forename: Cai-Yuan
authors.initials: CY
authors.lastname: Pan
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000179:Acrylates; D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D004317:Doxorubicin; C036658:acrylic acid
keywords: RAFT polymerization; biocompatibility; mesoporous silica nanoparticles; redox-responsive release