title: No effect of exercise on urinary 6-sulfatoxymelatonin and catecholamines in young women participating in a 16-week randomized controlled trial.
abstract: BACKGROUND
  Women with breast cancer have decreased levels of melatonin or its metabolite in plasma and/or urine.
  
  
  METHODS
  We measured serum melatonin, urinary 6-sulfatoxymelatonin, catecholamines, and cortisol in 141 sedentary young female participants in a clinical trial comparing 150 min/wk aerobic exercise for 4 months to no-exercise controls. Demographics, health surveys, body composition, sleep quality, fitness levels, and blood and urine samples were obtained at baseline and 16 weeks.
  
  
  RESULTS
  There were no differences between groups at baseline in demographics, exercise, sleep habits, or study hormones. There were also no significant differences between groups in any of the hormones at 16 weeks.
  
  
  CONCLUSIONS
  Sixteen weeks of exercise had minimal effects on melatonin secretion of young women.
  
  
  CONCLUSIONS
  There is convincing evidence that exercise protects against breast cancer, but this does not appear to occur through changes in melatonin secretion.
authors.affiliation: Department of Food Science and Nutrition, University of Minnesota, Saint Paul, MN 55108, USA. aarikawa@umn.edu
authors.forename: Andrea Y
authors.initials: AY
authors.lastname: Arikawa
authors.forename: William
authors.initials: W
authors.lastname: Thomas
authors.forename: Sanjay R
authors.initials: SR
authors.lastname: Patel
authors.forename: Mindy S
authors.initials: MS
authors.lastname: Kurzer
mesh_terms: D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism / Q000517:prevention & control / Q000652:urine*; D002395:Catecholamines / Q000097:blood / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D055815:Young Adult
chemical_list: D002395:Catecholamines; C054513:6-sulfatoxymelatonin; D008550:Melatonin