title: Assessment of L-arginine asymmetric 1 dimethyl (ADMA) in early-onset and late-onset (severe) preeclampsia.
abstract: Preeclampsia (PE) is characterized by hypertension and proteinuria. It has been classified in early or late according to gestational age at the onset of disease. Endothelial dysfunction plays a crucial part in its pathogenesis. NO is a potent vasodilator and ADMA is its endogenous inhibitor. We have assessed maternal ADMA levels. ADMA were increased in early [0.66 μmol/L] versus late sPE [0.47 μmol/L] (P=0.001) and versus normotensive pregnant [0.48 μmol/L] (P=0.001). Our findings suggest that high ADMA levels in early sPE could compromise NO synthesis contributing to endothelial dysfunction, leading to impaired placentation and the onset of this disease.
authors.affiliation: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Patrícia Nessralla
authors.initials: PN
authors.lastname: Alpoim
authors.forename: Lara Carvalho
authors.initials: LC
authors.lastname: Godoi
authors.forename: Letícia Gonçalves
authors.initials: LG
authors.lastname: Freitas
authors.forename: Karina Braga
authors.initials: KB
authors.lastname: Gomes
authors.forename: Luci Maria
authors.initials: LM
authors.lastname: Dusse
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis; D011225:Pre-Eclampsia / Q000097:blood* / Q000652:urine; D011247:Pregnancy
chemical_list: D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine
keywords: ADMA; Nitric oxide; Nitric oxide synthase; Preeclampsia