title: Calcium-mediated secondary cross-linking of bisphosphonated oligo(poly(ethylene glycol) fumarate) hydrogels.
abstract: This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.
authors.affiliation: Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: M Reza
authors.initials: MR
authors.lastname: Nejadnik
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.forename: Tokio
authors.initials: T
authors.lastname: Mimura
authors.forename: Zeinab Tahmasebi
authors.initials: ZT
authors.lastname: Birgani
authors.forename: Pamela
authors.initials: P
authors.lastname: Habibovic
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Itatani
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
authors.forename: Jons
authors.initials: J
authors.lastname: Hilborn
authors.forename: Dmitri
authors.initials: D
authors.lastname: Ossipov
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Mikos
authors.forename: Sander C G
authors.initials: SC
authors.lastname: Leeuwenburgh
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002118:Calcium / Q000737:chemistry* / Q000378:metabolism; D002448:Cell Adhesion; D004164:Diphosphonates / Q000138:chemical synthesis / Q000737:chemistry*; D019855:Ethylene Glycol; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D004164:Diphosphonates; D020100:Hydrogels; D007477:Ions; D011108:Polymers; D019855:Ethylene Glycol; D008274:Magnesium; D002118:Calcium
keywords: bisphosphonates; calcium-binding; coordination bonds; hydrogels; metal-polymer complexes