title: Evaluation of the toxic effects of municipal wastewater effluent on mice using omic approaches.
abstract: Municipal wastewater effluents (MWWE) contain a lot of trace organic pollutants, which will be a threat to environmental health. However, little information is available for the mixed toxicity of MWWE on mammals. In the present study, male mice were exposed to MWWE for 90 days, and then, histopathology and clinical biochemistry determination and transcriptomic and metabolomic profiling were conducted. The results showed that MWWE exposure resulted in injuries in liver and kidney. Combined transcriptomic and metabolomic data demonstrated that MWWE exposure induced perturbations of metabolism, including lipid, nucleotide, amino acid, and energy metabolism. Furthermore, dysregulation of signal transduction processes were also identified based on differentially expressed genes. These results suggested that chronic exposure to MWWE could induce hepatotoxicity and nephrotoxicity in mice and omic approaches are of practical value to evaluate the complex toxicity of MWWE.
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Kailong
authors.initials: K
authors.lastname: Huang
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Deng
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhao
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Ren
mesh_terms: D000818:Animals; D001835:Body Weight; D004326:Drinking; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D055442:Metabolome; D051379:Mice; D008813:Mice, Inbred ICR; D036401:Toxicity Tests, Chronic; D059467:Transcriptome; D062065:Wastewater / Q000633:toxicity*
chemical_list: D062065:Wastewater