title: Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome.
abstract: We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kinase inhibitor dasatinib the patient presented recurrent severe gastrointestinal hemorrhages linked to the genetic background and aggravated by thrombocytopenia.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Sartor
authors.forename: Cristina
authors.initials: C
authors.lastname: Papayannidis
authors.forename: Maria
authors.initials: M
authors.lastname: Chiara Abbenante
authors.forename: Ilaria
authors.initials: I
authors.lastname: Iacobucci
authors.forename: Alessandro
authors.initials: A
authors.lastname: Broccoli
authors.forename: Claudia
authors.initials: C
authors.lastname: Venturi
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Testoni
authors.forename: Anna
authors.initials: A
authors.lastname: Ferrari
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
keywords: Philadelphia chromosome; SMAD4; acute lymphoblastic leukemia; dasatinib; hemorrhage; hereditary hemorrhagic telangiectasia; juvenile poyposis