title: The cardiology and endocrinology connection between amiodarone and thyrotoxicosis: case report and review of the literature.
abstract: Amiodarone is used in a large number of cardiac conditions. Amiodarone-induced thyroid dysfunction has been reported to affect up to 20% of users. Amiodarone can lead to both amiodarone-induced hypothyroidism (AIH) and less commonly amiodarone-induced thyrotoxicosis (AIT). There are two main forms of AIT. Type 1 AIT, a form of io-dine-induced hyperthyroidism, and type 2, a drug-induced destructive thyroiditis. Type 1 AIT develops on individuals with underlying thyroid disease. Treatment of Type 1 AIT includes the use of antithyroid drugs and discontinuation of amiodarone. Type 2 AIT is commonly self-limiting in nature. In this article wedescribe a patient with Amiodarone-induced thyrotoxicosis discussing its clinical features and medical therapeutic approach.
authors.affiliation: Internal Medicine and Endocrinology Department, San Juan City Hospital, San Juan Puerto Rico. coropalermo@caribe.net
authors.forename: Coromoto
authors.initials: C
authors.lastname: Palermo-Garófalo
authors.forename: José Hernán
authors.initials: JH
authors.lastname: Martínez
authors.forename: Frieda
authors.initials: F
authors.lastname: Silva
authors.forename: Eva
authors.initials: E
authors.lastname: González
authors.forename: Oberto
authors.initials: O
authors.lastname: Torres
authors.forename: Jannette
authors.initials: J
authors.lastname: Figueroa
authors.forename: José
authors.initials: J
authors.lastname: González
authors.forename: Miranda María
authors.initials: MM
authors.lastname: de Lourdes
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D002309:Cardiology; D004704:Endocrinology; D005260:Female; D006801:Humans; D013971:Thyrotoxicosis / Q000139:chemically induced*
chemical_list: D000638:Amiodarone