title: Assisted reproduction in polycystic ovarian disease: A multicentric trial in India.
abstract: OBJECTIVE
  The aim of this study is to compare ovarian response, oocyte, embryo quality, ovarian hyperstimulation syndrome incidence, and pregnancy rates in polycystic ovary syndrome (PCOS) and non-PCOS group.
  
  
  METHODS
  This was a prospective observational study on PCOS carried out in seven assisted reproduction centers in India between August 2008 and July 2010, as part of trial under the Indian Society of Assisted Reproduction. A total of 192 women (77 in the PCOS group and 115 in the non- PCOS group) undergoing in vitro fertilization/intracytoplasmic sperm injection were included. All women had long protocol and recombinant follicle-stimulating hormone stimulation.
  
  
  METHODS
  The mean number of follicles and oocytes was higher in PCOS group compared with non-PCOS, being 27.2 (±8.8) and 13.6 (±5.3); 15.9 (±6.3) and 10.9 (±6.2), respectively. The recovery rates of oocytes and mature oocytes per follicle were less in the PCOS group which was 64% and 61.1%, respectively as opposed to 80.3% and 74.5%, respectively in non-PCOS group. The total numbers of top-quality embryos were less in the PCOS group.
  
  
  CONCLUSIONS
  In PCOS women though the number of follicles was more, recovery of mature oocytes, top-quality embryos was less. Pregnancy rates were comparable in both groups.
authors.affiliation: Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Karnataka, India.
authors.forename: Pratap
authors.initials: P
authors.lastname: Kumar
authors.forename: Natasha
authors.initials: N
authors.lastname: Nawani
authors.forename: Narendra
authors.initials: N
authors.lastname: Malhotra
authors.forename: Jaideep
authors.initials: J
authors.lastname: Malhotra
authors.forename: Madhuri
authors.initials: M
authors.lastname: Patil
authors.forename: K
authors.initials: K
authors.lastname: Jayakrishnan
authors.forename: Sujata
authors.initials: S
authors.lastname: Kar
authors.forename: Padma Rekha
authors.initials: PR
authors.lastname: Jirge
authors.forename: Nalini
authors.initials: N
authors.lastname: Mahajan
keywords: Fertilization response to ovulation induction; polycystic ovary syndrome