title: Group 2 innate lymphoid cells in lung inflammation.
abstract: Although allergic asthma is a heterogeneous disease, allergen-specific T helper 2 (Th2) cells producing the key cytokines involved in type 2 inflammation, interleukin-4 (IL-4), IL-5 and IL-13, are thought to play a major role in asthma pathogenesis. This model is challenged by the recent discovery of group 2 innate lymphoid cells (ILC2) that represent a critical innate source of type 2 cytokines. These ILC2 are activated by epithelial cell-derived cytokines, including IL-25 and IL-33, which have been implicated in the initiation of asthma. In this review, we will discuss recent studies supporting a significant role for ILC2 in lung inflammation, with special attention to allergen-induced asthma.
authors.affiliation: Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, the Netherlands.
authors.forename: Bobby W S
authors.initials: BW
authors.lastname: Li
authors.forename: Rudi W
authors.initials: RW
authors.lastname: Hendriks
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000276:immunology*; D011014:Pneumonia / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D000485:Allergens; D016207:Cytokines
keywords: T cells; asthma; innate immunity; lung immunology disease