title: Peptide-based Targeting of Fluorescent Zinc Sensors to the Plasma Membrane of Live Cells.
abstract: Combining fluorescent zinc sensors with the facile syntheses and biological targeting capabilities of peptides, we created green- and blue-emitting probes that, (i) are readily prepared on the solid-phase, (ii) retain the photophysical and zinc-binding properties of the parent sensor, and (iii) can be directed to the extracellular side of plasma membranes in live cells for detection of mobile zinc.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Radford
authors.forename: Wen
authors.initials: W
authors.lastname: Chyan
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lippard