title: Modulation of hepatic redox status and mitochondrial metabolism by exercise: therapeutic strategy for liver diseases.
abstract: Liver steatosis (non-alcoholic fatty liver disease, NAFLD) is deemed as the hepatic face of the metabolic syndrome, with both physical inactivity and hypercaloric/unbalanced diet, together with increasing age playing a role as predisposing factors. Consequently, one of the most effective strategies used to counteract this scenario is physical exercise. Given the importance of redox signaling in cellular remodeling, in which mitochondria are closely implicated along with important roles on substrate oxidation, here we briefly review the effects of both acute and chronic forms of physical exercise on the modulation of hepatic redox state, highlighting the relevance of mitochondrial metabolism and function in the induction of liver phenotypes that antagonize metabolic alterations associated with liver metabolic diseases.
authors.affiliation: Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal. Electronic address: aascensao@fade.up.pt.
authors.forename: António
authors.initials: A
authors.lastname: Ascensão
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Martins
authors.forename: Estela
authors.initials: E
authors.lastname: Santos-Alves
authors.forename: Inês O
authors.initials: IO
authors.lastname: Gonçalves
authors.forename: Piero
authors.initials: P
authors.lastname: Portincasa
authors.forename: Paulo J
authors.initials: PJ
authors.lastname: Oliveira
authors.forename: José
authors.initials: J
authors.lastname: Magalhães
mesh_terms: D015444:Exercise; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism / Q000628:therapy*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress
keywords: Bioenergetics; Liver disease; Oxidative damage; Physical activity