title: Synthesis of (2-alkylthiothiazolin-5-yl)methyl dodecanoates via tandem radical reaction.
abstract: A series of (2-alkylthiothiazolin-5-yl)methyl dodecanoates was synthesized from various alkyl N-allylcarbamodithioates and dilauroyl peroxide via a tandem radical hydrogen-abstraction-cyclization-substitution/combination reaction with a 5-exo-trig radical cyclization as a key step. The current route is the first, convenient, and efficient synthesis of (2-alkylthiothiazolin-5-yl)methanol derivatives.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering and Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Saeed
authors.initials: S
authors.lastname: Kakaei
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Xu
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D005609:Free Radicals; D007848:Laurates / Q000138:chemical synthesis* / Q000737:chemistry; D008054:Lipid Peroxides / Q000737:chemistry; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry
chemical_list: D005609:Free Radicals; D007848:Laurates; D008054:Lipid Peroxides; D013844:Thiazoles; D013859:Thiocarbamates; C035089:lauroyl peroxide