title: Use of tyrosine kinase inhibitors in a patient with Brugada syndrome and chronic myeloid leukemia.
abstract: The treatment and prognosis of chronic myeloid leukemia have dramatically changed since the introduction of tyrosine kinase inhibitors, but although several clinical trials have examined their safety with respect to heart function, no data are yet available about the use of these drugs in patients with Brugada syndrome. We report a case of Brugada syndrome diagnosed during tyrosine kinase inhibitor therapy in a 69-year-old Caucasian male with meningioma and chronic myeloid leukemia. This case report highlights the importance of an integrated approach among hematologists and cardiologists to ensure appropriate treatment with tyrosine kinase inhibitors in patients affected by chronic myeloid leukemia who also suffer from Brugada syndrome.
authors.affiliation: U.O. Ematologia con Trapianto, D.E.T.O., Universita' degli Studi di Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy, nicolasgherza@libero.it.
authors.forename: Nicola
authors.initials: N
authors.lastname: Sgherza
authors.forename: Antonella Vita
authors.initials: AV
authors.lastname: Russo Rossi
authors.forename: Paolo
authors.initials: P
authors.lastname: Colonna
authors.forename: Paola
authors.initials: P
authors.lastname: Carluccio
authors.forename: Mario
authors.initials: M
authors.lastname: Delia
authors.forename: Giorgina
authors.initials: G
authors.lastname: Specchia
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D053840:Brugada Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D004562:Electrocardiography; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors