title: Characteristics and outcome of pediatric non-Hodgkin lymphoma patients with ovarian infiltration at presentation.
abstract: BACKGROUND
  Ovarian infiltration in pediatric non-Hodgkin lymphoma (NHL) at presentation is rare and information on outcome is scarce and mainly based on case reports and small series.
  
  
  METHODS
  Evaluation of clinical characteristics and outcome of ovarian infiltrated pediatric NHL cases of a single center, and an extensive review of the all cases reported so far in literature.
  
  
  RESULTS
  At presentation, 6/60 female NHL cases of our center had ovarian infiltration, and combining these cases with earlier case reports, a total of 42 cases were identified. Median age at presentation was 10.9 years (range 0-18), and all but one had a B-cell immunophenotype, with 32/42 cases being classified as Burkitt. Bilateral involvement was reported in 26/41 cases, of which 22 were bilaterally ovariectomized as first treatment. All cases were treated with chemotherapy. Relapses were reported in 9/36 and death in 16/36. After follow-up in our center (median 13.4 years), in 2 cases anti-Müllerian hormone (AMH) values were available (2.1 and 0.9 µg/L), in non-ovarian cases median 2.2 µg/L.
  
  
  CONCLUSIONS
  We conclude that in case of ovarian tumors with negative markers, NHL should be considered in order to avoid unnecessary surgery.
authors.affiliation: Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center-Sophia's Children's Hospital, Rotterdam, The Netherlands; Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Wendy
authors.initials: W
authors.lastname: van Dorp
authors.forename: Catherine
authors.initials: C
authors.lastname: Owusuaa
authors.forename: Joop S E
authors.initials: JS
authors.lastname: Laven
authors.forename: Marry M
authors.initials: MM
authors.lastname: van den Heuvel-Eibrink
authors.forename: Auke
authors.initials: A
authors.lastname: Beishuizen
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome
keywords: gonadal function; non-Hodgkin lymphoma; ovarian infiltration; pediatric