title: Role of polycomb proteins in regulating HSV-1 latency.
abstract: Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.
authors.affiliation: Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Box 100266, Gainesville, FL 32610, USA.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Watson
authors.forename: Adit
authors.initials: A
authors.lastname: Dhummakupt
authors.forename: Harald
authors.initials: H
authors.lastname: Messer
authors.forename: Dane
authors.initials: D
authors.lastname: Phelan
authors.forename: David
authors.initials: D
authors.lastname: Bloom
mesh_terms: D015967:Gene Expression Regulation, Viral; D018259:Herpesvirus 1, Human / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D063146:Polycomb-Group Proteins / Q000378:metabolism*; D017735:Virus Latency
chemical_list: D063146:Polycomb-Group Proteins