title: Applicability of 3T body MRI in assessment of nonfocal bone marrow involvement of hematopoietic neoplasia in dogs.
abstract: BACKGROUND
  The utility of whole body magnetic resonance imaging (MRI) in detecting bone marrow infiltration in dogs with cancer has not been investigated.
  
  
  OBJECTIVE
  To assess the feasibility of 3T body MRI for bone marrow assessment in dogs with hematopoietic neoplasia.
  
  
  METHODS
  Seven dogs with B-cell lymphoma, 3 dogs with myelodysplastic syndrome (MDS), and 2 clinically normal dogs.
  
  
  METHODS
  A prospective study of dogs with hematopoetic cancer was conducted using T1W, T2W, In-Phase, Out-of-Phase and STIR pulse sequences of the body excluding the head prior to bone marrow sampling. The relative signal intensity of a midlumbar vertebral body and a midshaft femoral bone marrow was compared by visual and point region of interest analysis to regional skeletal muscle.
  
  
  RESULTS
  Similarity of femoral diaphyseal and vertebral body marrow signal intensity to that of skeletal muscle on the Out-of-Phase sequence was useful in distinguishing the 3 dogs with hypercellular marrow because of MDS from the 7 dogs with B-cell lymphoma and from the 2 clinically normal dogs. 1/7 dogs with lymphoma had proven bone marrow involvement but normal cellularity and less than 5% abnormal cells. Unaffected midfemoral marrow had greater signal intensity than skeletal muscle and unaffected vertebral marrow had less signal intensity than skeletal muscle on the Out-of-Phase sequence.
  
  
  CONCLUSIONS
  3T, Out-of-Phase MR pulse sequence was useful in distinguishing diffuse bone marrow infiltrate (MDS) from minimally or unaffected marrow using skeletal muscle for signal intensity comparison on whole body MRI.
authors.affiliation: Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN.
authors.forename: D A
authors.initials: DA
authors.lastname: Feeney
authors.forename: L C
authors.initials: LC
authors.lastname: Sharkey
authors.forename: S M
authors.initials: SM
authors.lastname: Steward
authors.forename: K L
authors.initials: KL
authors.lastname: Bahr
authors.forename: M S
authors.initials: MS
authors.lastname: Henson
authors.forename: D
authors.initials: D
authors.lastname: Ito
authors.forename: T D
authors.initials: TD
authors.lastname: O'Brien
authors.forename: C R
authors.initials: CR
authors.lastname: Jessen
authors.forename: B D
authors.initials: BD
authors.lastname: Husbands
authors.forename: A
authors.initials: A
authors.lastname: Borgatti
authors.forename: J
authors.initials: J
authors.lastname: Modiano
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D016393:Lymphoma, B-Cell / Q000150:complications / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D009367:Neoplasm Staging / Q000379:methods / Q000662:veterinary*
keywords: Lymphoma; MR pulse sequence; Magnetic resonance; Marrow signal intensity; Myelodysplasia