title: The rs2233678 polymorphism in PIN1 promoter region reduced cancer risk: a meta-analysis.
abstract: BACKGROUND
  Published evidence suggests that the rs2233678 (-842 G>C) polymorphism in the PIN1 (peptidyl-prolyl cis/trans somerase NIMA-interacting 1) promoter region may be associated with cancer risk; however, the conclusion is still inconclusive.
  
  
  METHODS
  We conducted a meta-analysis to determine whether -842 G>C polymorphism was associated with cancer risk. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Genotype distribution data and adjusted ORs were collected to calculate the pooled ORs. Meta-regression was conducted to detect the source of heterogeneity. Publication bias was evaluated by Egger's test and Begg's test.
  
  
  RESULTS
  A total of 11 eligible studies, including 9280 participants, were identified and analyzed. Overall, we found that carriers of the -842 C allele were associated with significantly decreased cancer risk (C vs. G, OR = 0.750, 95% CI: 0.639-0.880, P(heterogeneity )= 0.014, estimated by genotype distribution data; CC+GC vs. GG, OR = 0.668, 95% CI: 0.594-0.751, P(heterogeneity) = 0.638, estimated by adjusted ORs). No evidence of publication bias was observed. Meta-regression revealed that ethnicities (p = 0.021) and sample size (p = 0.02) but not sources of control (p = 0.069) were the source of heterogeneity.
  
  
  CONCLUSIONS
  These results suggest that the PIN1 rs2233678 (-842 G>C) polymorphism significantly reduces cancer risk.
authors.affiliation: Department of Oncology, Shanghai First People's Hospital Affiliated Shanghai Jiaotong University, Shanghai, China. liqisjt@126.com
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Zhao
authors.initials: Z
authors.lastname: Dong
authors.forename: Yun
authors.initials: Y
authors.lastname: Lin
authors.forename: Xinyan
authors.initials: X
authors.lastname: Jia
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Liwei
authors.initials: L
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000483:Alleles; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D019696:Peptidylprolyl Isomerase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D017594:Publication Bias; D012306:Risk
chemical_list: D000072340:NIMA-Interacting Peptidylprolyl Isomerase; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase