title: [Changes of retinal neurons and Muller glial cells in patients with type II diabetes in treatment of diabetic retinopathy with angiotensin-converting enzyme inhibitor].
abstract: Flicker-ERG (FERG) amplitude and glial indices Cg were measured to estimate angiotensin- converting enzyme (ACE) inhibitor Perindopril effect on retinal glial-neuronal interactions in patients with type II diabetes and diabetic retinopathy (DR). Intake of 5 mg Perindopril daily during 2 months improved photoreceptor and bipolar cells function in all stages of DR with the most significant effect in preproliferative DR (PPDR). After treatment course initially supernormal FERG scotopic glial indices reduced by 8,3-12 Hz (25-33%) in nonproliferative DR and PPDR and by 10% in proliferative DR. In photopic conditions moderate decrease of index was revealed in FERG by 30Hz only in PPDR. Obtained results show Perindopril to cause significant improvement of retinal glial-neuronal interactions in dark adaptation and poor positive dynamics in photopic conditions.
authors.forename: M V
authors.initials: MV
authors.lastname: Zueva
authors.forename: I V
authors.initials: IV
authors.lastname: Tsapenko
authors.forename: M V
authors.initials: MV
authors.lastname: Riabina
authors.forename: T D
authors.initials: TD
authors.lastname: Okhomtsimskaia
authors.forename: M I
authors.initials: MI
authors.lastname: Grinchenko
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D003623:Dark Adaptation / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D003930:Diabetic Retinopathy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000187:drug effects / Q000473:pathology*; D020913:Perindopril / Q000008:administration & dosage / Q000627:therapeutic use*; D055351:Retinal Neurons / Q000187:drug effects / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D020913:Perindopril