title: Long-term consequences of subarachnoid hemorrhage: examining working memory.
abstract: Working memory impairments are prevalent among survivors of aneurysmal subarachnoid hemorrhage (SAH), but few studies have examined specifically these impairments. Such an examination is important because working memory processes are vital for daily cognitive functioning. In the current study, patients with SAH and healthy control participants were administered the word-span and alpha-span test - experimental tests of working memory. In the word-span test, participants recalled increasingly longer word-lists, requiring the maintenance of information in mind. In the alpha-span test, participants recalled the word-lists in alphabetical order, requiring both the maintenance and manipulation of information. Patients with SAH were no different from healthy controls on a battery of standard neuropsychological measures or on the word-span test. They were, however, significantly impaired on the alpha-span test, suggesting a deficit in the manipulation components of working memory. That is, impairment resulting from SAH is present when a working memory task requires additional executive processing demands. This deficit in patients with SAH does not appear to be influenced by aneurysm location, suggesting that some of the effects of SAH on cognition are from diffuse rather than focal pathology; however, a larger sample size is needed to reinforce this claim.
authors.affiliation: Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada. signy.sheldon@utoronto.ca
authors.forename: Signy
authors.initials: S
authors.lastname: Sheldon
authors.forename: R Loch
authors.initials: RL
authors.lastname: Macdonald
authors.forename: Michael
authors.initials: M
authors.lastname: Cusimano
authors.forename: Julian
authors.initials: J
authors.lastname: Spears
authors.forename: Tom A
authors.initials: TA
authors.lastname: Schweizer
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D014706:Verbal Learning
keywords: Cognition; Cognitive science; Executive function; Memory; Stroke recovery; Subarachnoid hemorrhage