title: LHRH-PE40 fusion protein tethered silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy.
abstract: Docyanine green (ICG) and LHRH-PE40 fusion protein are tethered onto drug carriers of silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy. The synergistic therapeutic effect of toxin PE40 and the chemotherapeutic drug docetaxel (Dtxl), specifically directed by LHRH to cancer, improves cancer treatment. Simultaneously, ICG enables real-time monitoring of the silica nanocomposites and therapeutic response.
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
authors.forename: Fuping
authors.initials: F
authors.lastname: Gao
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.forename: Liya
authors.initials: L
authors.lastname: Nie
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: Fangqiong
authors.initials: F
authors.lastname: Tang
mesh_terms: D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D005098:Exotoxins / Q000235:genetics*; D007987:Gonadotropin-Releasing Hormone / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D057054:Molecular Imaging; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity; D050997:Nanomedicine; D011550:Pseudomonas aeruginosa; D011993:Recombinant Fusion Proteins / Q000737:chemistry* / Q000235:genetics; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D005098:Exotoxins; D011993:Recombinant Fusion Proteins; D007987:Gonadotropin-Releasing Hormone; D012822:Silicon Dioxide
keywords: LHRH fusion protein; bimodal therapy; multifunction; nanotheranostics; silica nanorattle