title: [The yield of tigecycline in the treatment of community-acquired pneumonia].
abstract: Tigecycline is a novel antibiotic and it is the first glycylcycline of the tetracycline antibiotic class. It exhibits potent in vitro activity against causative pathogens that are most frequently isolated in patients with community-acquired pneumonia. The objective of this study is to review the literature about the efficacy of tigecycline in community-acquired pneumonia. Two randomized clinical studies showed tigecycline was not inferior when compared with levofloxacin for the treatment of patients with bacterial community-acquired pneumonia requiring hospitalization. Tigecycline was generally well tolerated in patients with community-acquired pneumonia. Major adverse effects were primarily gastrointestinal in nature. Tigecycline offers an antibiotic option that can be used in hospitalized patients with mild to moderate community-acquired pneumonia.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Akdeniz University, Antalya, Turkey. aykutcilli@hotmail.com
authors.forename: Aykut
authors.initials: A
authors.lastname: Cilli
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008911:Minocycline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D000078304:Tigecycline; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline