title: Models and strategies in the development of antiobesity drugs.
abstract: Obesity is a leading cause of morbidity and mortality worldwide. There is still a wide disparity between the necessity and availability of safe and effective antiobesity pharmacotherapies. Current drugs are associated with adverse effects and are limited in their efficacy. There is thus an urgent need for new antiobesity agents. Animal models are critical to the study of the biological mechanisms underpinning energy homeostasis and obesity and provide useful tools for the development of novel antiobesity agents. Our understanding of the complex neuronal and hormonal systems that regulate appetite and body weight has largely been based on studies in animals. This review describes the physiological basis of appetite, rodent models used in the development of antiobesity drugs, and potential future targets for novel antiobesity agents.
authors.affiliation: Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK. Email: k.g.murphy@imperial.ac.uk.
authors.forename: A
authors.initials: A
authors.lastname: Agahi
authors.forename: K G
authors.initials: KG
authors.lastname: Murphy
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology*; D001066:Appetite / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D054439:Ghrelin / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009765:Obesity / Q000188:drug therapy*; D053772:Oxyntomodulin / Q000494:pharmacology; D011323:Primates; D051381:Rats; D013552:Swine
chemical_list: D019440:Anti-Obesity Agents; D054439:Ghrelin; D053772:Oxyntomodulin
keywords: animal; antiobesity drugs; appetite; models; obesity