title: Contribution of dysfunction of maternal hemodynamics to renal impairment in preeclampsia.
abstract: OBJECTIVE
  To investigate the contribution of dysfunction of maternal hemodynamics to renal impairment in preeclampsia (PE).
  
  
  METHODS
  Urinary protein excretion, serum creatinine, blood urea nitrogen, uric acid, and glomerular filtration rate were assessed in 571 pregnant women with PE in addition to and noninvasive hemodynamic monitoring. Patients were classified into two groups: PE with renal impairment (glomerular filtration rate <90 ml/min/1.73 m², n = 161) and PE with normal renal function (n = 410). Cut-off values for hemodynamic parameters were calculated using receiver-operating characteristic curve analysis.
  
  
  RESULTS
  Maternal systolic function and cardiac output parameters were low and peripheral resistance was high in the PE renal impairment group. Cut-off values for the hemodynamic parameters, cardiac index, cardiac output, systemic vascular resistance index, and systemic vascular resistance were 2.85 l/min/m², 5.25 l/min, 3,014.5 dyn s cm⁻⁵ m² and 1,636.0 dyn s cm⁻⁵, respectively, according to receiver-operating characteristics curves.
  
  
  CONCLUSIONS
  Renal impairment in PE is associated with reduced maternal cardiac output and increased peripheral resistance.
authors.affiliation: State Key Laboratory of Reproductive Medicine, Department of Obstetrics, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, PR China.
authors.forename: Rui-Zhe
authors.initials: RZ
authors.lastname: Jia
authors.forename: Yu-Jia
authors.initials: YJ
authors.lastname: Qian
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.forename: Hong-Juan
authors.initials: HJ
authors.lastname: Ding
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Wu
authors.forename: Ke-Mei
authors.initials: KM
authors.lastname: Shao
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D002307:Cardiography, Impedance; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011507:Proteinuria / Q000652:urine; D012372:ROC Curve; D051437:Renal Insufficiency / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D013318:Stroke Volume; D014527:Uric Acid / Q000097:blood; D014655:Vascular Resistance; D055815:Young Adult
chemical_list: D014527:Uric Acid; D003404:Creatinine