title: A clinical manifestation-based prediction of haemodynamic patterns of orthostatic intolerance in children: a multi-centre study.
abstract: OBJECTIVE
  At present, the haemodynamic diagnosis of orthostatic intolerance is based mainly on the head-up tilt table test, which is sometimes risky for patients. Thus, it is important to find objective and safe methods to differentiate haemodynamic patterns of orthostatic intolerance cases.
  
  
  METHODS
  In all, 629 children with orthostatic intolerance, either vasovagal syncope or postural orthostatic tachycardia syndrome, were included in the multi-centre clinical study. We analysed the association between the clinical manifestation and haemodynamic patterns of the patients.
  
  
  RESULTS
  Syncope after motion with a prodrome of chest distress or palpitations and the concomitant symptom(s) after a syncopal attack, with debilitation, dizziness or headache, were the most important variables in predicting the diagnosis of vasovagal syncope. The overall diagnostic accuracy was 71.5%.
  
  
  CONCLUSIONS
  Complaint of syncope after motion with prodromal chest distress or palpitation and the concomitant symptom after a syncopal attack, with subsequent debilitation, dizziness or headache, were the most important variables in the diagnosis of vasovagal syncope in children with orthostatic intolerance.
authors.affiliation: 1Department of Pediatrics,Peking University First Hospital,Beijing,China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: 2Department of Statistics,Peking University First Hospital,Beijing,China.
authors.forename: Xueying
authors.initials: X
authors.lastname: Li
authors.affiliation: 3Department of Pediatrics,Northwestern University Feinberg School of Medicine,Chicago,Illinois,United States ofAmerica.
authors.forename: Ochs
authors.initials: O
authors.lastname: Todd
authors.affiliation: 4The Second Hospital of Xiangya,Zhongnan University,Changsha,China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: 1Department of Pediatrics,Peking University First Hospital,Beijing,China.
authors.forename: Hongfang
authors.initials: H
authors.lastname: Jin
authors.affiliation: 1Department of Pediatrics,Peking University First Hospital,Beijing,China.
authors.forename: Junbao
authors.initials: J
authors.lastname: Du
mesh_terms: D000293:Adolescent; D001794:Blood Pressure; D002637:Chest Pain; D002648:Child; D002675:Child, Preschool; D016002:Discriminant Analysis; D004244:Dizziness; D005260:Female; D006261:Headache; D006339:Heart Rate; D006439:Hemodynamics; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008487:Medical History Taking; D009325:Nausea; D005996:Nitroglycerin; D054971:Orthostatic Intolerance / Q000175:diagnosis; D054972:Postural Orthostatic Tachycardia Syndrome / Q000175:diagnosis*; D062706:Prodromal Symptoms; D012680:Sensitivity and Specificity; D016683:Supine Position; D019462:Syncope, Vasovagal / Q000175:diagnosis*; D018667:Tilt-Table Test; D014665:Vasodilator Agents; D014839:Vomiting
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin