title: New phenethylamine derivatives from Arenibacter nanhaiticus sp. nov. NH36A(T) and their antimicrobial activity.
abstract: Five new phenethylamine (PEA) derivatives (1-5) were isolated from the strain of Arenibacter nanhaiticus sp. nov. NH36A(T) derived from the marine sediment of the South China Sea by bioassay-guided fractionation. Their structures were elucidated by spectroscopic methods including UV, IR, HR-MS and NMR. Interestingly, compounds 1-4 existed as enantiomers, which were resolved by chiral liquid chromatography. The resolved configuration of each enantiomer was assigned by the Marfey's method. Of these compounds, 5 showed weak antimicrobial activity against Staphylococcus aureus and Bacillus subtilis with MIC values of 0.50 and 0.25 mg ml(-1), respectively.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, PR China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Chen
authors.forename: Jinshan
authors.initials: J
authors.lastname: Tang
authors.forename: Xixiang
authors.initials: X
authors.lastname: Tang
authors.forename: Chuanxi
authors.initials: C
authors.lastname: Wang
authors.forename: Yunyang
authors.initials: Y
authors.lastname: Lian
authors.forename: Zongze
authors.initials: Z
authors.lastname: Shao
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D002681:China; D002853:Chromatography, Liquid; D041965:Flavobacteriaceae / Q000737:chemistry*; D019015:Geologic Sediments / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D009792:Oceans and Seas; D010627:Phenethylamines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D010627:Phenethylamines