title: Mucins help to avoid alloreactivity at the maternal fetal interface.
abstract: During gestation, many different mechanisms act to render the maternal immune system tolerant to semi-allogeneic trophoblast cells of foetal origin, including those mediated via mucins that are expressed during the peri-implantation period in the uterus. Tumour- associated glycoprotein-72 (TAG-72) enhances the already established tolerogenic features of decidual dendritic cells with the inability to progress towards Th1 immune orientation due to lowered interferon (IFN)- γ and interleukin (IL)-15 expression. Mucine 1 (Muc 1) supports alternative activation of decidual macrophages, restricts the proliferation of decidual regulatory CD56(+) bright natural killer (NK) cells, and downregulates their cytotoxic potential, including cytotoxic mediator protein expression. Removing TAG-72 and Muc 1 from the eutopic implantation site likely contributes to better control of trophoblast invasion by T cells and NK cells and appears to have important immunologic advantages for successful implantation, in addition to mechanical advantages. However, these processes may lead to uncontrolled trophoblast growth after implantation, inefficient defence against infection or tumours, and elimination of unwanted immunocompetent cells at the maternal-foetal interface. The use of mucins by tumour cells to affect the local microenvironment in order to avoid the host immune response and to promote local tumour growth, invasion, and metastasis confirms this postulation.
authors.affiliation: Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia. redzovica@gmail.com
authors.forename: Arnela
authors.initials: A
authors.lastname: Redzovic
authors.forename: Gordana
authors.initials: G
authors.lastname: Laskarin
authors.forename: Marin
authors.initials: M
authors.lastname: Dominovic
authors.forename: Herman
authors.initials: H
authors.lastname: Haller
authors.forename: Daniel
authors.initials: D
authors.lastname: Rukavina
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics / Q000276:immunology; D003656:Decidua / Q000166:cytology / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D010064:Embryo Implantation / Q000276:immunology; D005260:Female; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D019409:Interleukin-15 / Q000235:genetics / Q000276:immunology; D008431:Maternal-Fetal Exchange / Q000276:immunology; D018396:Mucin-1 / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy; D014327:Trophoblasts / Q000166:cytology / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D006023:Glycoproteins; D019409:Interleukin-15; C060192:MUC1 protein, human; D018396:Mucin-1; C047052:tumor-associated antigen 72; D007371:Interferon-gamma