title: Impact of autogenous concentrated bone marrow aspirate on bone regeneration after sinus floor augmentation with a bovine bone substitute--a split-mouth pilot study.
abstract: OBJECTIVE
  Mesenchymal stem cells (MSC) with biomaterials have osteoinductive potential. The aim of this study was to evaluate early bone formation in xenogenic sinus grafts in a direct comparison with and without MSCs after 3 and 6 months. Literature on bone formation in pure xenogenic graft materials after 3 months in a human model is still lacking.
  
  
  METHODS
  In a split-mouth design, seven patients with a bilateral highly atrophic posterior maxilla were included. The test side was grafted with MSCs from concentrated bone marrow aspirate admixed to the bone graft material. On the control side, pure bovine bone material was applied. Biopsies were taken navigated after 3 and 6 months.
  
  
  RESULTS
  After 3 months, new bone formation in the control group was 11.8% (SD 6.2%) and in the test group 7.4% (SD 4.1%). After 6 months, the control group showed 13.9% (SD 8.5%) of new bone and the test group 13.5% NB (SD 5.4%). The fraction of bovine bone material after 3 months was 42.6% (SD 3.5%) in the test group and 34.9% (SD 11.8%) in the control group. After 6 months, the biomaterial content was comparable at both sides (test 36.2%, SD 7.8%; control 39.5%, SD 9.3%).
  
  
  CONCLUSIONS
  There was no significant difference in new bone formation between the test and control group with n = 7. The results may be dominated by the high mineral content of the biomaterial but could nevertheless be valuable for meta-analysis in the future.
authors.affiliation: Department of Oral Surgery and Radiology, Medical University of Graz, Graz, Austria.
authors.forename: Angelika
authors.initials: A
authors.lastname: Wildburger
authors.forename: Michael
authors.initials: M
authors.lastname: Payer
authors.forename: Norbert
authors.initials: N
authors.lastname: Jakse
authors.forename: Dirk
authors.initials: D
authors.lastname: Strunk
authors.forename: Nathalie
authors.initials: N
authors.lastname: Etchard-Liechtenstein
authors.forename: Sebastian
authors.initials: S
authors.lastname: Sauerbier
mesh_terms: D000368:Aged; D000818:Animals; D001284:Atrophy; D001706:Biopsy; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D005260:Female; D006801:Humans; D007085:Ilium; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D010865:Pilot Projects; D059546:Sinus Floor Augmentation / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008903:Minerals
keywords: bone regeneration; bone substitutes; clinical research; clinical trials; guided tissue regeneration; sinus floor elevation