title: Strategies in the development of vaccines to prevent infections with group A streptococcus.
abstract: There has long been interest and demand for the development of a vaccine to prevent infections caused by the Gram-positive organism group A streptococcus. Despite numerous efforts utilizing advanced approaches such as genomics, proteomics and bio-informatics, there is currently no vaccine. Here we review various strategies employed to achieve this goal. We also discuss the approach that we have pursued, a non-host reactive, conformationally constrained minimal B cell epitope from within the C-repeat region of M-protein, and the potential limitations in moving forward.
authors.affiliation: Institute for Glycomics; Griffith University, Gold Coast campus; QLD Australia.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Good
authors.forename: Michael R
authors.initials: MR
authors.lastname: Batzloff
authors.forename: Manisha
authors.initials: M
authors.lastname: Pandey
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology; D055808:Drug Discovery / Q000639:trends; D018985:Epitopes, B-Lymphocyte / Q000276:immunology; D006801:Humans; D013290:Streptococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022541:Streptococcal Vaccines / Q000276:immunology* / Q000302:isolation & purification; D013297:Streptococcus pyogenes / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D018985:Epitopes, B-Lymphocyte; D022541:Streptococcal Vaccines; C014689:streptococcal M protein
keywords: J8-DT; group A streptococcus; rheumatic fever; rheumatic heart disease; vaccination