title: Effect of hydrophobic modifications in antimicrobial peptides.
abstract: With increasing resistance development against conventional antibiotics, there is an urgent need to identify novel approaches for infection treatment. Antimicrobial peptides may offer opportunities in this context, hence there has been considerable interest in identification and optimization of such peptides during the last decade in particular, with the long-term aim of developing these to potent and safe therapeutics. In the present overview, focus is placed on hydrophobic modifications of antimicrobial peptides, and how these may provide opportunities to combat also more demanding pathogens, including multi-resistant strains, yet not provoking unacceptable toxic responses. In doing so, physicochemical factors affecting peptide interactions with bacterial and eukaryotic cell membranes are discussed. Throughout, an attempt is made to illustrate how physicochemical studies on model lipid membranes can be correlated to result from bacterial and cell assays, and knowledge from this translated into therapeutic considerations.
authors.affiliation: Section of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden.
authors.forename: Artur
authors.initials: A
authors.lastname: Schmidtchen
authors.affiliation: Section of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Pasupuleti
authors.affiliation: Department of Pharmacy, Uppsala University, P.O. Box 580, SE-751 23 Uppsala, Sweden. Electronic address: martin.malmsten@farmaci.uu.se.
authors.forename: Martin
authors.initials: M
authors.lastname: Malmsten
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000737:chemistry*; D001419:Bacteria / Q000737:chemistry / Q000166:cytology; D002462:Cell Membrane / Q000737:chemistry; D005057:Eukaryotic Cells / Q000737:chemistry / Q000166:cytology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions
chemical_list: D023181:Antimicrobial Cationic Peptides
keywords: AMP; Antimicrobial peptide; Bacteria; Liposome; Membrane