title: Increased total Renin levels but not Angiotensin-converting enzyme activity in obese patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate the renin-angiotensin-aldosterone system and angiotensin-converting enzyme (ACE) activity in patients with polycystic ovarian syndrome (PCOS).
  
  
  METHODS
  In this case-control study, 41 obese (PCOS) women and 29 healthy controls, matched for age and body mass index, were enrolled. Anthropometric, metabolic, and hormonal patterns, including plasma aldosterone, plasma renin, and ACE activity, were measured in each subject.
  
  
  RESULTS
  Plasma renin levels were significantly higher in PCOS patients (19.7 ± 14.5 µg/ml) compared with controls (12.9 ± 9.0 µg/ml, p < 0.05). ACE activity and aldosterone levels did not significantly differ between both groups (p = 0.15 and p = 0.18, respectively). Analysis of PCOS patients showed a significant correlation of fasting insulin levels with levels of renin (r = 0.305, p < 0.01) and free testosterone (r = 0.384, p = 0.001). Similarly, homeostasis model assessment index was positively correlated with total renin concentrations (r = 0.366, p < 0.01) and free testosterone (r = 0.352, p < 0.01).
  
  
  CONCLUSIONS
  Obese PCOS women had higher total renin levels, but not ACE activity and aldosterone levels, related to insulin resistance compared with controls.
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Ziynet
authors.initials: Z
authors.lastname: Alphan
authors.forename: Zehra
authors.initials: Z
authors.lastname: Berberoglu
authors.forename: Suheyla
authors.initials: S
authors.lastname: Gorar
authors.forename: Zehra
authors.initials: Z
authors.lastname: Candan
authors.forename: Aynur
authors.initials: A
authors.lastname: Aktas
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Aral
authors.forename: Esranur
authors.initials: E
authors.lastname: Ademoglu
mesh_terms: D050154:Adiposity / Q000502:physiology; D000328:Adult; D015992:Body Mass Index; D001837:Body Weights and Measures; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D009765:Obesity / Q000097:blood* / Q000209:etiology / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000378:metabolism; D012083:Renin / Q000097:blood* / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology*
chemical_list: D006728:Hormones; D012083:Renin
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