title: Risk of malignancy index validity assessment in premenopausal and postmenopausal women with adnexal tumors.
abstract: OBJECTIVE
  The aim of this study was to investigate the validity of the risk of malignancy index (RMI) in premenopausal and postmenopausal patients with adnexal masses.
  
  
  METHODS
  The study involved all women treated for adnexal tumors throughout an 18-month period in the Clinic for Gynecology and Obstetrics, Clinical Center of Serbia (Belgrade, Serbia). On admission, detailed anamnestic and laboratory data were obtained and an expert ultrasound scan was performed. The RMI was calculated for all patients and the obtained data were related to histopathological findings of the tumors. For statistical analysis, we used descriptive and analytical statistics methods and an SPSS computer program.
  
  
  RESULTS
  From a total number of 540 women, 85 women had malignant tumors; 20 women, borderline tumors; and 435 women, benign adnexal tumors. The RMI was reliable in 84.6% of all patients; in 77% of premenopausal patients, and in 81.1% of postmenopausal patients. The sensitivity of the RMI in the overall population was 83.81%; the specificity was 77.24%; the positive predictive value (PPV) was 47.06%, and the negative predictive value (NPV) was 95.18%. In premenopausal women, the RMI sensitivity was 83.87%; specificity, 80.31%; PPV, 28.89%; and NPV, 98.12%. In postmenopausal women the RMI sensitivity was 83.78%; specificity, 68.18%; PPV, 63.92%; and NPV, 74.71%.
  
  
  CONCLUSIONS
  The RMI was a reliable factor for differentiating benign from malignant adnexal masses in premenopausal and postmenopausal patients.
authors.affiliation: Clinic of Obstetrics and Gynecology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. terzicmilan@yahoo.co.uk
authors.forename: Milan
authors.initials: M
authors.lastname: Terzic
authors.forename: Jelena
authors.initials: J
authors.lastname: Dotlic
authors.forename: Ivana
authors.initials: I
authors.lastname: Likic
authors.forename: Natasa
authors.initials: N
authors.lastname: Brndusic
authors.forename: Igor
authors.initials: I
authors.lastname: Pilic
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Ladjevic
authors.forename: Sanja
authors.initials: S
authors.lastname: Maricic
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Arsenovic
authors.forename: Zoran
authors.initials: Z
authors.lastname: Maricic
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D018294:Neoplasms, Adnexal and Skin Appendage / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology; D017698:Postmenopause; D011237:Predictive Value of Tests; D017697:Premenopause; D012372:ROC Curve; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods / Q000592:standards; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055771:Serbia / Q000453:epidemiology; D014463:Ultrasonography
keywords: adnexal masses; postmenopause; premenopause; risk of malignancy index