title: Promoters, toll like receptors and microRNAs: a strange association.
abstract: Toll-like receptors (TLRs) are proteins that play key role in the innate immune system. In the present study, -1000 base pairs upstream are taken from the transcription start site of the various TLR genes (10 known) in human. About 40 microRNAs have been identified that share 12-19 nucleotide sequence similarity with the promoter regions of 10 TLRs. It is proposed that the microRNA performs potential role in identification of promoter sequence and initiation of transcription.
authors.affiliation: School of Life Sciences, University of Hyderabad, Hyderabad, India.
authors.forename: Kalyani
authors.initials: K
authors.lastname: Korla
authors.forename: Patrizio
authors.initials: P
authors.lastname: Arrigo
authors.forename: Chanchal K
authors.initials: CK
authors.lastname: Mitra
mesh_terms: D056726:Genetic Association Studies / Q000379:methods*; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D051193:Toll-Like Receptors / Q000235:genetics*; D015533:Transcriptional Activation / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D051193:Toll-Like Receptors