title: Cell signaling, receptors, electrical effects and therapy in circadian rhythm.
abstract: Circadian rhythm has been the object of much attention. This review addresses the aspects of cell signaling, receptors, therapy and electrical effects in a multifaceted fashion. The pineal gland, which produces the important hormones melatonin and serotonin, exerts a prominent influence, in addition to the supraschiasmatic nucleus. Many aspects involve free radicals which have played a widespread role in biochemistry.
authors.affiliation: Department of Chemistry and Biochemistry, San Diego State University, San Diego , CA , USA and.
authors.forename: Peter
authors.initials: P
authors.lastname: Kovacic
authors.forename: Ratnasamy
authors.initials: R
authors.lastname: Somanathan
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002940:Circadian Rhythm / Q000235:genetics* / Q000502:physiology; D004565:Electroconvulsive Therapy; D006801:Humans; D020179:Jet Lag Syndrome / Q000503:physiopathology / Q000628:therapy; D008550:Melatonin / Q000378:metabolism*; D010870:Pineal Gland / Q000378:metabolism*; D020813:Receptor, trkB / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics; D020178:Sleep Disorders, Circadian Rhythm / Q000503:physiopathology / Q000628:therapy
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D012701:Serotonin; D020813:Receptor, trkB; D008550:Melatonin