title: A histone modifier's ill-gotten copy gains.
abstract: Little is known about the molecular machinery that contributes to site-specific copy number variations or how CNVs fit into the chronology of tumor progression. Black et al. (2013) now demonstrate that the overexpression of a histone demethylase induces transient copy gain of specific genomic loci known to harbor proto-oncogenes.
authors.affiliation: Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Rickels
authors.forename: Ali
authors.initials: A
authors.lastname: Shilatifard
mesh_terms: D004261:DNA Replication; D018628:Gene Dosage; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics*
chemical_list: D056484:Jumonji Domain-Containing Histone Demethylases; C494424:KDM4A protein, human