title: A miR-146a polymorphism (rs2910164) predicts risk of and survival from colorectal cancer.
abstract: BACKGROUND
  Recent evidence suggests that the rs2910164 variant of miR-146a is associated with the development of certain types of cancer. Therefore, the aim of this study was to investigate the association of this genetic variant with susceptibility and prognosis in patients with colorectal cancer (CRC).
  
  
  METHODS
  Genotyping analyses of miR-146a rs2690164 for risk and survival in CRC were performed in a case-control study (n=967) using a polymerase chain reaction (PCR)-restriction fragment length polymorphism assay.
  
  
  RESULTS
  The C allelic frequency of miR-146 rs2690164 in the 399 patients and 568 controls was 61.9% and 53.9%, respectively. In the case-control study, those who possessed the CC genotype had a higher risk of CRC compared to those with the CG or GG genotype (odds ratio=1.569; 95% confidence interval=1.196-2.059; p=0.001), regardless of the tumor site. In the survival analysis of 343 patients with CRC who underwent curative surgery, those with CC genotype had a worse survival outcome compared with those with CG or GG genotype in a Kaplan-Meier survival analysis. Moreover, a multivariate analysis showed that the CC genotype of miR-146a rs2910164 was associated with worse relapse-free and disease-specific survival compared to the CG or GG genotype in a recessive model of the C allele, adjusted for patient and tumor characteristics (hazard ratio=2.120 and 2.349, p=0.005 and 0.007, respectively).
  
  
  CONCLUSIONS
  The current study provides evidence that the miR-146a rs2690164 polymorphism, as the dominant model of the G allele, is associated with the susceptibility and prognosis of CRC.
authors.affiliation: Kyungpook National University Medical Center, Kyungpook National University School of Medicine, 807 Hogukno, Buk-Gu, Daegu 702-210, Korea. jkk21c@knu.ac.kr
authors.forename: Yee Soo
authors.initials: YS
authors.lastname: Chae
authors.forename: Jong Gwang
authors.initials: JG
authors.lastname: Kim
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Lee
authors.forename: Byung Woog
authors.initials: BW
authors.lastname: Kang
authors.forename: Yoo Jin
authors.initials: YJ
authors.lastname: Lee
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
authors.forename: Hyo-Sung
authors.initials: HS
authors.lastname: Jeon
authors.forename: Jun Seok
authors.initials: JS
authors.lastname: Park
authors.forename: Gyu Seog
authors.initials: GS
authors.lastname: Choi
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000601:surgery; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs
keywords: Colorectal cancer; miR-146a polymorphism; prognosis; risk; rs2910164