title: Emergence of GABAergic-dependent regulation of input-specific plasticity in the adult rat prefrontal cortex during adolescence.
abstract: OBJECTIVE
  The prefrontal cortex (PFC) receives multiple cortical and subcortical afferents that regulate higher order cognitive functions, many of which emerge late in adolescence. However, it remains unclear how these afferents influence PFC processing, especially in light of the protracted, late adolescent maturation of prefrontal GABAergic function. Here we investigated the role of PFC GABAergic transmission in regulating plasticity elicited from the ventral hippocampus and basolateral amygdala, and how such modulation undergoes functional changes during adolescence in rats.
  
  
  METHODS
  In vivo local field potential recordings, combined with prefrontal microinfusion of the GABA-A receptor antagonist picrotoxin, were employed to study the impact of ventral hippocampal and basolateral amygdala high-frequency stimulation on PFC plasticity.
  
  
  RESULTS
  Ventral hippocampal-induced PFC plasticity begins to appear only by postnatal days (P) 45-55 with a transient suppression of the evoked response. A switch from transient to long-lasting depression (LTD) of the PFC response emerges after P55 and throughout adulthood (P65-120). Recordings conducted in the presence of picrotoxin revealed that PFC GABAergic transmission is critical for the expression of LTD. In contrast, basolateral amygdala stimulation resulted in PFC long-term potentiation, a form of plasticity that is already enabled by P30 and is insensitive to picrotoxin.
  
  
  CONCLUSIONS
  The development of ventral hippocampal-dependent PFC LTD is contingent upon the recruitment of local prefrontal GABAergic transmission during adolescence whereas plasticity elicited from the basolateral amygdala is not. Thus, different mechanisms contribute to the refinement of prefrontal plasticity during adolescence as inputs from these two regions are critical for shaping PFC functions.
authors.affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Rd, North Chicago, IL, 60064, USA.
authors.forename: Adriana
authors.initials: A
authors.lastname: Caballero
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Thomases
authors.forename: Eden
authors.initials: E
authors.lastname: Flores-Barrera
authors.forename: Daryn K
authors.initials: DK
authors.lastname: Cass
authors.forename: Kuei Y
authors.initials: KY
authors.lastname: Tseng
mesh_terms: D000818:Animals; D066272:Basolateral Nuclear Complex / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D004558:Electric Stimulation; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008839:Microelectrodes; D009434:Neural Pathways / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D010852:Picrotoxin / Q000494:pharmacology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000254:growth & development* / Q000502:physiology*; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D058787:GABA-A Receptor Antagonists; D010852:Picrotoxin; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid
references.citation: Child Dev. 2010 Nov-Dec;81(6):1641-60
references.pmid: 21077853
references.citation: J Comp Neurol. 2002 Nov 11;453(2):116-30
references.pmid: 12373778
references.citation: Hippocampus. 2000;10(4):438-46
references.pmid: 10985283
references.citation: Mol Psychiatry. 2001 Jan;6(1):13-34
references.pmid: 11244481
references.citation: Synapse. 2011 Apr;65(4):278-86
references.pmid: 20687106
references.citation: Nat Rev Neurosci. 2008 Dec;9(12):947-57
references.pmid: 19002191
references.citation: J Neurosci. 2003 Jun 1;23(11):4406-9
references.pmid: 12805280
references.citation: Cereb Cortex. 2005 Jan;15(1):49-57
references.pmid: 15217899
references.citation: Schizophr Bull. 2011 May;37(3):484-92
references.pmid: 21505115
references.citation: Behav Brain Res. 2006 Dec 15;175(2):329-36
references.pmid: 17045348
references.citation: Nature. 1999 Nov 18;402(6759):294-6
references.pmid: 10580500
references.citation: Physiol Rev. 2006 Jul;86(3):1033-48
references.pmid: 16816145
references.citation: J Neurophysiol. 2013 Jul;110(1):221-9
references.pmid: 23657281
references.citation: Neuropsychologia. 2011 Mar;49(4):745-59
references.pmid: 20950634
references.citation: Schizophr Bull. 1989;15(4):585-93
references.pmid: 2623440
references.citation: J Neurosci. 2012 Aug 8;32(32):10915-24
references.pmid: 22875926
references.citation: Schizophr Bull. 2011 May;37(3):514-23
references.pmid: 21505118
references.citation: Biol Psychiatry. 2001 Jul 15;50(2):71-83
references.pmid: 11526998
references.citation: Annu Rev Psychol. 2012;63:129-51
references.pmid: 22129456
references.citation: Brain Res. 1996 May 13;720(1-2):211-9
references.pmid: 8782914
references.citation: Learn Mem. 2010 May 26;17(6):289-96
references.pmid: 20504949
references.citation: J Physiol. 2012 Feb 15;590(4):669-81
references.pmid: 22250212
references.citation: J Comp Neurol. 1996 May 20;369(1):1-15
references.pmid: 8723699
references.citation: Behav Brain Res. 2009 Dec 7;204(2):295-305
references.pmid: 19100784
references.citation: Behav Neurosci. 1995 Dec;109(6):1063-73
references.pmid: 8748957
references.citation: J Neurosci. 2013 Jan 2;33(1):26-34
references.pmid: 23283319
references.citation: Cereb Cortex. 2013 Jun;23(6):1396-409
references.pmid: 22615141
references.citation: Behav Neurosci. 1995 Aug;109(4):681-8
references.pmid: 7576212
references.citation: Biol Psychiatry. 2014 Mar 15;75(6):508-16
references.pmid: 24041503
references.citation: J Neurosci. 2003 Nov 5;23(31):9987-95
references.pmid: 14602812
references.citation: J Comp Neurol. 2010 Jul 15;518(14):2693-709
references.pmid: 20506471
references.citation: Trends Neurosci. 2008 Apr;31(4):183-91
references.pmid: 18329735
references.citation: Brain Res. 2002 Aug 16;946(2):314-22
references.pmid: 12137936
references.citation: Neuropharmacology. 2011 May;60(6):953-62
references.pmid: 21288471
references.citation: J Comp Neurol. 1995 Dec 25;363(4):615-641
references.pmid: 8847421
references.citation: Biol Psychiatry. 2013 Oct 1;74(7):490-501
references.pmid: 23558299
references.citation: Brain Struct Funct. 2014 Jan;219(1):395-406
references.pmid: 23400698
references.citation: Brain Struct Funct. 2007 Sep;212(2):149-79
references.pmid: 17717690
references.citation: J Neurosci. 1997 Mar 1;17(5):1880-90
references.pmid: 9030646
references.citation: Biol Psychol. 2000 Oct;54(1-3):241-57
references.pmid: 11035225
references.citation: Dev Psychopathol. 2009 Winter;21(1):87-97
references.pmid: 19144224
references.citation: J Comp Neurol. 1997 Jan 27;377(4):465-99
references.pmid: 9007187