title: An assessment of in ovo toxicity of the flame retardant 1,2-dibromo-4-(1,2-dibromoethyl) cyclohexane (TBECH) in the zebra finch.
abstract: Embryonic toxicity of a brominated flame retardant, TBECH (1,2-dibromo-4-(1, 2-dibromoethyl) cyclohexane) was investigated using the zebra finch (Taeniopygia guttata) as our model. Using in ovo dosing procedures, we injected the technical TBECH compound, consisting of 50:50 α-/β-isomers, directly into the yolk of freshly laid eggs at concentrations of 2.3-94 ng/g egg. No significant effects were observed in terms of growth or survival for either pre-hatch embryos or post-hatch chicks. Analysis of tissue samples at various developmental stages suggests that α-/β-TBECH was metabolized rapidly, and thus is unlikely to cause any direct, long-term effects on the development of zebra finch embryos or offspring.
authors.affiliation: Department of Biological Sciences, Simon Fraser University, 8888 University Dr., Burnaby, BC, V5A 1S6, Canada, hscherr@sfu.ca.
authors.forename: Heidi A
authors.initials: HA
authors.lastname: Currier
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Letcher
authors.forename: Tony D
authors.initials: TD
authors.lastname: Williams
authors.forename: John E
authors.initials: JE
authors.lastname: Elliott
mesh_terms: D000818:Animals; D003510:Cyclohexanes / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D046369:Finches; D005411:Flame Retardants / Q000633:toxicity*; D010063:Ovum / Q000187:drug effects*
chemical_list: D003510:Cyclohexanes; D004785:Environmental Pollutants; D005411:Flame Retardants; C517232:1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane