title: Update in the treatment of high-grade Gliomas.
abstract: Advances in the molecular classification of high-grade gliomas are laying the groundwork for potential changes in the treatment of high-grade gliomas. Currently, a combined modality approach involving surgery, radiation therapy, and chemotherapy is most often used in the treatment of high-grade gliomas. The authors review recent advances in the treatment of these primary brain tumors.
authors.affiliation: Department of Neurology, University of Chicago, IL 60637, USA. rlukas@neurology.bsd.uchicago.edu
authors.forename: Rimas V
authors.initials: RV
authors.lastname: Lukas
authors.forename: Martin Kelly
authors.initials: MK
authors.lastname: Nicholas
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000235:genetics / Q000628:therapy*; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005910:Glioma / Q000235:genetics / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy; D000077204:Temozolomide
chemical_list: D000970:Antineoplastic Agents; D003606:Dacarbazine; D000077204:Temozolomide
keywords: Chemotherapy; Gliomas; Radiation therapy; Surgery