title: The glucose signaling network in yeast.
abstract: BACKGROUND
  Most cells possess a sophisticated mechanism for sensing glucose and responding to it appropriately. Glucose sensing and signaling in the budding yeast Saccharomyces cerevisiae represent an important paradigm for understanding how extracellular signals lead to changes in the gene expression program in eukaryotes.
  
  
  METHODS
  This review focuses on the yeast glucose sensing and signaling pathways that operate in a highly regulated and cooperative manner to bring about glucose-induction of HXT gene expression.
  
  
  CONCLUSIONS
  The yeast cells possess a family of glucose transporters (HXTs), with different kinetic properties. They employ three major glucose signaling pathways-Rgt2/Snf3, AMPK, and cAMP-PKA-to express only those transporters best suited for the amounts of glucose available. We discuss the current understanding of how these pathways are integrated into a regulatory network to ensure efficient uptake and utilization of glucose.
  
  
  CONCLUSIONS
  Elucidating the role of multiple glucose signals and pathways involved in glucose uptake and metabolism in yeast may reveal the molecular basis of glucose homeostasis in humans, especially under pathological conditions, such as hyperglycemia in diabetics and the elevated rate of glycolysis observed in many solid tumors.
authors.affiliation: Department of Biochemistry and Molecular Medicine, The George Washington University Medical Center, 2300 Eye Street, Washington, DC 20037, USA. Electronic address: jh_kim@gwu.edu.
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Adhiraj
authors.initials: A
authors.lastname: Roy
authors.forename: David
authors.initials: D
authors.lastname: Jouandot
authors.forename: Kyu Hong
authors.initials: KH
authors.lastname: Cho
mesh_terms: D001692:Biological Transport; D005947:Glucose / Q000378:metabolism*; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics / Q000378:metabolism; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D051246:Glucose Transport Proteins, Facilitative; D029701:Saccharomyces cerevisiae Proteins; D005947:Glucose
keywords: Cancer; Glucose signaling pathways; Glucose transporters; Glucose uptake and metabolism; Yeast
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