title: Metabolic remodeling in chronic heart failure.
abstract: Although the management of chronic heart failure (CHF) has made enormous progress over the past decades, CHF is still a tremendous medical and societal burden. Metabolic remodeling might play a crucial role in the pathophysiology of CHF. The characteristics and mechanisms of metabolic remodeling remained unclear, and the main hypothesis might include the changes in the availability of metabolic substrate and the decline of metabolic capability. In the early phases of the disease, metabolism shifts toward carbohydrate utilization from fatty acids (FAs) oxidation. Along with the progress of the disease, the increasing level of the hyperadrenergic state and insulin resistance cause the changes that shift back to a greater FA uptake and oxidation. In addition, a growing body of experimental and clinical evidence suggests that the improvement in the metabolic capability is likely to be more significant than the selection of the substrate.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002331:Carnitine / Q000494:pharmacology; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D005318:Fetal Heart / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D013831:Thiamine / Q000494:pharmacology; D014292:Trimetazidine / Q000494:pharmacology; D020257:Ventricular Remodeling
chemical_list: D005227:Fatty Acids; D018377:Neurotransmitter Agents; D000255:Adenosine Triphosphate; D005947:Glucose; D014292:Trimetazidine; D002331:Carnitine; D013831:Thiamine
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