title: Intraoperative fluid administration is associated with perioperative outcomes in pancreaticoduodenectomy: a single center retrospective analysis.
abstract: BACKGROUND
  Recent studies on perioperative fluid administration in patients undergoing major abdominal surgery have suggested that increased fluid loads are associated with worse perioperative outcomes. However, results of retrospective analyses of the relationship between intraoperative fluid (IOF) administration and perioperative outcomes in patients undergoing pancreaticoduodenectomy (PD) are conflicted. We sought to investigate this relationship in patients undergoing PD at our academic center.
  
  
  METHODS
  A retrospective analysis of 124 patients undergoing PD from 2007 to 2012 was performed. IOF administration rate (ml/kg/hr) was correlated with perioperative outcomes. Outcomes were also stratified by preoperative serum albumin level.
  
  
  RESULTS
  Regression analyses were performed comparing independent perioperative variables, including IOF rate, to four outcomes variables: length of stay, severity of complications, number of complications per patient, and 30-day mortality. Both univariate and multivariate regression analyses showed IOF rate correlated with one or more perioperative outcomes. Patients with an albumin ≤ 3.0 g/dl who received more than the median IOF rate experienced more severe complications, while patients with an albumin >3.0 g/dl did not.
  
  
  CONCLUSIONS
  Increased IOF administration is associated with worse perioperative outcomes in patients undergoing PD. Patients with low preoperative serum albumin levels (≤ 3.0 g/dl) may be a group particularly sensitive to volume overload.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Rutgers-Robert Wood Johnson Medical School/Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
authors.forename: Oliver S
authors.initials: OS
authors.lastname: Eng
authors.forename: Julie
authors.initials: J
authors.lastname: Goswami
authors.forename: Dirk
authors.initials: D
authors.lastname: Moore
authors.forename: Chunxia
authors.initials: C
authors.lastname: Chen
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Gannon
authors.forename: David A
authors.initials: DA
authors.lastname: August
authors.forename: Darren R
authors.initials: DR
authors.lastname: Carpizo
mesh_terms: D000368:Aged; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D012709:Serum Albumin
keywords: morbidity; pancreas; surgery; volume
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