title: Ruthenium-catalyzed redox-neutral and single-step amide synthesis from alcohol and nitrile with complete atom economy.
abstract: A completely atom-economical and redox-neutral catalytic amide synthesis from an alcohol and a nitrile is realized. The amide C-N bond is efficiently formed between the nitrogen atom of nitrile and the α-carbon of alcohol, with the help of an N-heterocyclic carbene-based ruthenium catalyst, without a single byproduct. A utility of the reaction was demonstrated by synthesizing (13)C or (15)N isotope-labeled amides without involvement of any separate reduction and oxidation step.
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science, Seoul 151-742, Republic of Korea.
authors.forename: Byungjoon
authors.initials: B
authors.lastname: Kang
authors.forename: Zhenqian
authors.initials: Z
authors.lastname: Fu
authors.forename: Soon Hyeok
authors.initials: SH
authors.lastname: Hong
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis*; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry*; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000577:Amides; D009570:Nitriles; C030011:carbene; D012428:Ruthenium; D008697:Methane