title: Haptic guided virtual reality simulation for targeted drug delivery using nano-containers manipulation.
abstract: When dealing with nano targeted drug delivery process the significant area of virtual reality application can be visualizing real time process and simulating it at nano-scale, since the effectiveness of a drug primarily depends on the affected cell and targeted doze. This paper proposes virtual reality (VR) as a tool to analyze and simulate nanoparticles (NPs) manipulation, in this paper amorphous NPs are analyzed and simulated in virtual environment. Haptic guides virtualizing the atomic force microscope (AFM) is applied in the virtual environment which allows the operators to sense and touch the NPs when evaluating its structure, drug release time, and behavioral study. Cisplatin was loaded as a modal drug to the self-assembled amorphous copolymer P(3HV-co-4HB)-b-mPEG NPs, where the efficiency and bioavailability of Cisplatin was further investigated. The prepared NPs when simulated in virtual environment proved to show good biocompatibility. Results showed that amorphous polymeric NPs could be efficient vehicles for the constant and targeted delivery of toxic anticancer drugs.
authors.affiliation: School of Mechanical and Aerospace Engineering and ReCAPT, Gyeongsang National University, Jinju 660-701, Korea.
authors.forename: Syed
authors.initials: S
authors.lastname: Hassan
authors.forename: Mohsin
authors.initials: M
authors.lastname: Shah
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Yoon
authors.forename: Ikram
authors.initials: I
authors.lastname: Ullah
authors.forename: Myeong Ok
authors.initials: MO
authors.lastname: Kim
authors.forename: Jungwon
authors.initials: J
authors.lastname: Yoon
mesh_terms: D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D008846:Micromanipulation / Q000379:methods*; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry*; D014110:Touch; D014584:User-Computer Interface
chemical_list: D053769:Nanocapsules