title: Proteostasis in complex dendrites.
abstract: Like all cells, neurons are made of proteins that have characteristic synthesis and degradation profiles. Unlike other cells, however, neurons have a unique multipolar architecture that makes ∼10,000 synaptic contacts with other neurons. Both the stability and modifiability of the neuronal proteome are crucial for its information-processing, storage and plastic properties. The cell biological mechanisms that synthesize, modify, deliver and degrade dendritic and synaptic proteins are not well understood but appear to reflect unique solutions adapted to the particular morphology of neurons.
authors.affiliation: The Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany.
authors.forename: Cyril
authors.initials: C
authors.lastname: Hanus
authors.forename: Erin M
authors.initials: EM
authors.lastname: Schuman
mesh_terms: D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology*; D003712:Dendrites / Q000378:metabolism*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D011328:Prions / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D011328:Prions
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