title: Emerging approaches in fermentative production of statins.
abstract: Microbial metabolites have many important applications in pharmaceutical and health-care industry. The products of microbial origin are usually produced by submerged fermentation. The solid-state fermentation represents an alternative mode of fermentation, which is increasingly being employed as an alternative to submerged fermentation for metabolite production. The prospect of producing high-value product using low-value raw material offers a substantial premium to switch to these technologies. The cost of statins being one major factor, solid-state fermentation with agro-industrial residues as carbon, nitrogen and support matrix, promises to substantially lower the cost of production. Hence, newer approaches are required to exploit the agro-industrial residues for statin production. The development of these technologies offers an opportunity to exploit low-cost substrates without substantial investment in newer production methodologies. The emerging evidence of beneficial effect of statins in applications other than lipid lowering such as in Alzheimer disease, HIV, age-related dementia, and cancer chemotherapy makes it very important to develop methods for economic production of statins.
authors.affiliation: Microbiology Division, CSIR-Central Drug Research Institute (CDRI), B 10/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226 031, India, sudheer.vns@gmail.com.
authors.forename: Sudheer Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Ashok
authors.initials: A
authors.lastname: Pandey
mesh_terms: D019149:Bioreactors; D005285:Fermentation / Q000502:physiology*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000378:metabolism*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors