title: Canine cytochrome P-450 pharmacogenetics.
abstract: The cytochrome P-450 (CYP) drug metabolizing enzymes are essential for the efficient elimination of many clinically used drugs. These enzymes typically display high interindividual variability in expression and function resulting from enzyme induction, inhibition, and genetic polymorphism thereby predisposing patients to adverse drug reactions or therapeutic failure. There are also substantial species differences in CYP substrate specificity and expression that complicate direct extrapolation of information from humans to veterinary species. This article reviews the available published data regarding the presence and impact of genetic polymorphisms on CYP-dependent drug metabolism in dogs in the context of known human-dog CYP differences.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA. Michael.Court@vetmed.wsu.edu
authors.forename: Michael H
authors.initials: MH
authors.lastname: Court
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism*; D004285:Dogs / Q000235:genetics* / Q000378:metabolism*; D004364:Pharmaceutical Preparations; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic / Q000502:physiology*; D013379:Substrate Specificity
chemical_list: D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System
keywords: Canine; Cytochrome P-450; Dog; Genetic polymorphism; Pharmacokinetics
references.citation: Drug Metab Dispos. 2010 Jul;38(7):1015-8
references.pmid: 20382755
references.citation: Drug Metab Dispos. 2003 Sep;31(9):1161-9
references.pmid: 12920172
references.citation: Handb Exp Pharmacol. 2010;(199):49-77
references.pmid: 20204583
references.citation: J Vet Pharmacol Ther. 2011 Feb;34(1):98-100
references.pmid: 21219354
references.citation: J Vet Pharmacol Ther. 2010 Feb;33(1):50-5
references.pmid: 20444025
references.citation: Drug Metab Dispos. 2006 Nov;34(11):1811-6
references.pmid: 16882764
references.citation: Drug Metab Dispos. 2006 May;34(5):800-6
references.pmid: 16473917
references.citation: Anesthesiology. 2001 Jan;94(1):110-9
references.pmid: 11135730
references.citation: J Pharmacol Exp Ther. 1994 Jul;270(1):414-23
references.pmid: 8035341
references.citation: Drug Metab Dispos. 2004 Feb;32(2):240-5
references.pmid: 14744947
references.citation: Pharm Res. 2012 Jul;29(7):1832-42
references.pmid: 22354837
references.citation: Drug Metab Lett. 2007 Apr;1(2):163-5
references.pmid: 19356037
references.citation: J Vet Pharmacol Ther. 2011 Apr;34(2):184-6
references.pmid: 21395610
references.citation: Drug Metab Dispos. 1998 Mar;26(3):278-83
references.pmid: 9492393
references.citation: Arch Toxicol. 2006 Nov;80(11):732-8
references.pmid: 16639591
references.citation: Xenobiotica. 2004 Sep;34(9):835-46
references.pmid: 15742977
references.citation: Am J Vet Res. 1993 May;54(5):755-60
references.pmid: 8317769
references.citation: Drug Metab Dispos. 1999 Nov;27(11):1293-9
references.pmid: 10534314
references.citation: Drug Metab Dispos. 2008 Sep;36(9):1903-8
references.pmid: 18573860
references.citation: Am J Vet Res. 1985 Aug;46(8):1677-83
references.pmid: 4037494
references.citation: Drug Metab Dispos. 2006 May;34(5):880-6
references.pmid: 16467132
references.citation: Drug Metab Dispos. 2009 Mar;37(3):457-61
references.pmid: 19074522
references.citation: Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11725-30
references.pmid: 15289602
references.citation: Drug Metab Pharmacokinet. 2002;17(1):75-82
references.pmid: 15618655
references.citation: Drug Metab Dispos. 2012 Feb;40(2):228-31
references.pmid: 22074769
references.citation: Xenobiotica. 2003 Mar;33(3):225-37
references.pmid: 12637241
references.citation: Drug Metab Dispos. 1999 Oct;27(10):1133-42
references.pmid: 10497139
references.citation: Arch Biochem Biophys. 1998 Sep 1;357(1):27-36
references.pmid: 9721180
references.citation: Am J Vet Res. 1988 Feb;49(2):245-9
references.pmid: 3348533
references.citation: Am J Vet Res. 1986 Oct;47(10):2105-12
references.pmid: 3777630
references.citation: Vet Clin North Am Small Anim Pract. 2006 Sep;36(5):975-85, v
references.pmid: 16984823
references.citation: Am J Vet Res. 1995 Jan;56(1):95-9
references.pmid: 7695156
references.citation: Xenobiotica. 2000 Jun;30(6):575-88
references.pmid: 10923860
references.citation: Drug Metab Dispos. 2010 Mar;38(3):396-404
references.pmid: 20007294
references.citation: Clin Tech Small Anim Pract. 1999 Feb;14(1):38-43
references.pmid: 10193044
references.citation: Drug Metab Dispos. 2000 Aug;28(8):981-6
references.pmid: 10901710