title: Perspective on the discovery and scientific impact of p38 MAP kinase.
abstract: It has now been almost 20 years since the discovery of p38 MAP kinase and its role in inflammatory cytokine synthesis through reverse pharmacology and its subsequent exploration as a potential target for autoimmune and other diseases. At the time of its discovery, the use of cell-based phenotypic screens to identify new molecular targets was at its infancy, and while p38 MAP kinase was not the first target to be identified this way, it provides a useful model for reviewing the pros and cons of this approach and the subsequent impact it can have on discovering new medicines.
authors.affiliation: 1Resverlogix Inc., San Francisco, CA, USA.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Young
mesh_terms: D000818:Animals; D001681:Biological Assay; D055808:Drug Discovery; D006801:Humans; D058990:Molecular Targeted Therapy; D010641:Phenotype; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D047428:Protein Kinase Inhibitors; D048051:p38 Mitogen-Activated Protein Kinases
keywords: drug discovery; p38 MAPK; phenotypic assay; protein kinases; reverse pharmacology