title: A partial differential equation model of metastasized prostatic cancer.
abstract: Biochemically failing metastatic prostate cancer is typically treated with androgen ablation. However, due to the emergence of castration-resistant cells that can survive in low androgen concentrations, such therapy eventually fails. Here, we develop a partial differential equation model of the growth and response to treatment of prostate cancer that has metastasized to the bone. Existence and uniqueness results are derived for the resulting free boundary problem. In particular, existence and uniqueness of solutions for all time are proven for the radially symmetric case. Finally, numerical simulations of a tumor growing in 2-dimensions with radial symmetry are carried in order to evaluate the therapeutic potential of different treatment strategies. These simulations are able to reproduce a variety of clinically observed responses to treatment, and suggest treatment strategies that may result in tumor remission, underscoring our model's potential to make a significant contribution in the field of prostate cancer therapeutics.
authors.affiliation: Department of Mathematics, Ohio State University, Columbus, OH 43210, USA. afriedman@mbi.osu.edu
authors.forename: Avner
authors.initials: A
authors.lastname: Friedman
authors.forename: Harsh Vardhan
authors.initials: HV
authors.lastname: Jain
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use; D000728:Androgens / Q000097:blood; D001859:Bone Neoplasms / Q000473:pathology* / Q000556:secondary* / Q000628:therapy; D049109:Cell Proliferation / Q000187:drug effects; D003198:Computer Simulation; D006801:Humans; D008297:Male; D055641:Mathematical Concepts; D008954:Models, Biological; D011157:Population Dynamics; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000628:therapy; D049490:Systems Biology
chemical_list: D000726:Androgen Antagonists; D000728:Androgens; D017430:Prostate-Specific Antigen