title: Management of rodent exposure and allergy in the pediatric population.
abstract: Although rodent allergy has long been recognized as an occupational disease, it has only been in the past decade that it has been recognized as a community-based disease that affects children. Most homes in the US have detectable mouse allergen, but the concentrations in inner-city homes are orders of magnitude higher than those found in suburban homes. Home mouse allergen exposure has been linked to sensitization to mouse, and children with asthma who are both sensitized and exposed to high mouse allergen concentrations at home are at greater risk for symptoms, exacerbations and reduced lung function. Rat allergen is found primarily in inner-city homes and has also been linked to asthma morbidity among sensitized children. The objective of this review is to summarize the scientific literature on rodents and their allergens, the effects of exposure to these allergens on allergic respiratory disease, and to make recommendations, based on this evidence base, for the evaluation and management of mouse allergy in the pediatric population.
authors.affiliation: The Johns Hopkins Hospital, CMSC 1102, 600 N. Wolfe Street, Baltimore, MD, 21287, USA, ematsui@jhmi.edu.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Matsui
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D002648:Child; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D012306:Risk; D012377:Rodentia / Q000276:immunology*
chemical_list: D000485:Allergens
references.citation: Environ Health Perspect. 2009 Mar;117(3):387-91
references.pmid: 19337513
references.citation: Occup Environ Med. 2007 Apr;64(4):267-72
references.pmid: 17053016
references.citation: Pediatr Allergy Immunol. 2012 Sep;23(6):543-9
references.pmid: 22672325
references.citation: Environ Health Perspect. 2003 Aug;111(10):1348-51
references.pmid: 12896857
references.citation: Curr Allergy Asthma Rep. 2012 Oct;12(5):438-47
references.pmid: 22791068
references.citation: Ann Allergy Asthma Immunol. 2006 Oct;97(4):514-20
references.pmid: 17069107
references.citation: Allergy. 2009 Jun;64(6):855-61
references.pmid: 19154543
references.citation: J Allergy Clin Immunol. 2007 Apr;119(4):910-5
references.pmid: 17337296
references.citation: J Allergy Clin Immunol. 2008 Nov;122(5):914-20
references.pmid: 19000580
references.citation: J Allergy Clin Immunol. 1994 Nov;94(5):810-7
references.pmid: 7963149
references.citation: J Allergy Clin Immunol. 2009 Sep;124(3):447-53
references.pmid: 19647861
references.citation: J Allergy Clin Immunol. 1981 Oct;68(4):310-8
references.pmid: 7288048
references.citation: Arch Pediatr Adolesc Med. 2011 Aug;165(8):741-8
references.pmid: 21810636
references.citation: J Allergy Clin Immunol. 2004 Jun;113(6):1167-71
references.pmid: 15208600
references.citation: J Allergy Clin Immunol. 2013 Oct;132(4):830-5.e1-2
references.pmid: 23810154
references.citation: Ann Allergy Asthma Immunol. 2003 Feb;90(2):223-5
references.pmid: 12602670
references.citation: Protein Sci. 2002 Sep;11(9):2247-56
references.pmid: 12192080
references.citation: Ann Allergy Asthma Immunol. 2004 Apr;92(4):420-5
references.pmid: 15104193
references.citation: Ann Allergy Asthma Immunol. 2008 Apr;100(4):358-63
references.pmid: 18450122
references.citation: J Allergy Clin Immunol. 2008 Apr;121(4):933-9
references.pmid: 18325579
references.citation: J Occup Environ Hyg. 2010 Dec;7(12):726-34
references.pmid: 21058157
references.citation: J Allergy Clin Immunol. 2003 Aug;112(2):346-52
references.pmid: 12897741
references.citation: Ann Allergy Asthma Immunol. 2008 Nov;101(5):517-23
references.pmid: 19055206
references.citation: Ann Allergy Asthma Immunol. 2012 Dec;109(6):375-87
references.pmid: 23176873
references.citation: Ann Allergy Asthma Immunol. 2008 Jul;101(1):35-41
references.pmid: 18681082
references.citation: J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):227-31
references.pmid: 9949312
references.citation: Pediatrics. 2011 Jan;127(1):93-101
references.pmid: 21149427
references.citation: Environ Health Perspect. 2006 Apr;114(4):522-6
references.pmid: 16581539
references.citation: J Allergy Clin Immunol. 2004 May;113(5):910-5
references.pmid: 15131574
references.citation: J Allergy Clin Immunol. 2000 Dec;106(6):1075-80
references.pmid: 11112889
references.citation: J Allergy Clin Immunol. 2005 Feb;115(2):358-63
references.pmid: 15696095
references.citation: Indoor Air. 2013 Aug;23(4):268-74
references.pmid: 23067271
references.citation: J Allergy Clin Immunol. 2000 Dec;106(6):1070-4
references.pmid: 11112888
references.citation: Eur Respir J. 1999 Aug;14(2):352-6
references.pmid: 10515413
references.citation: Mol Immunol. 1980 Sep;17(9):1087-95
references.pmid: 7442685