title: [High ratio of omega 6/omega 3 ratio children with neuropathies; cause or effect].
abstract: BACKGROUND
  The n-3 and n-6 fatty acids compete for the same elongases and desaturases, still highly deficient synthesis of polyunsaturated fatty acids from n-3 linolenic acid. The n-3 polyunsaturated prevent disease and are important in the development and maintenance of neuronal activities, necessitating a proper relationship with their antagonists n-6. This paper studies the proportion of these fatty acids.
  
  
  METHODS
  We analyzed the fatty acids of n- 3 and n-6 in sera and membrane phospholipid with 374 children neuropathies and 34 healthy children, using gas chromatography with mass detector. It has made the relevant statistical study.
  
  
  RESULTS
  The n-3 (EPA and DHA) in serum and their corresponding membrane phospholipids correlate better than the n-6 family. The major n-6 (LA and ARA) are equally in serum, being significantly higher in phospholipids of healthy children. The n-3 (EPA and DHA) have higher values in healthy children, both in serum and phospholipids, their sum is equal to the membrane phospholipids. The n-6/n-3 ratio is higher in children with neurological disorder in both samples.
  
  
  CONCLUSIONS
  Not being the cause of the high rate n-6/n- 3 neuropathy, however it is advisable to increase the intake of n-3, DHA particularly across the population, especially in children with neurological disorders.
authors.affiliation: Departamento de Farmacología, Pediatría y Q. Orgánica, Universidad Miguel Hernández, España.
authors.forename: E
authors.initials: E
authors.lastname: Cortés
authors.forename: M J
authors.initials: MJ
authors.lastname: Hidalgo
authors.forename: M M
authors.initials: MM
authors.lastname: Rizo-Baeza
authors.forename: M J
authors.initials: MJ
authors.lastname: Aguilar
authors.forename: V
authors.initials: V
authors.lastname: Gil
mesh_terms: D002648:Child; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000097:blood* / Q000453:epidemiology; D010743:Phospholipids / Q000378:metabolism
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D010743:Phospholipids