title: Development of multi-walled carbon nanotubes reinforced monetite bionanocomposite cements for orthopedic applications.
abstract: In this study, we present results of our research on biodegradable monetite (DCPA, CaHPO4) cement with surface-modified multi-walled carbon nanotubes (mMWCNTs) as potential bone defect repair material. The cement pastes showed desirable handling properties and possessed a suitable setting time for use in surgical setting. The incorporation of mMWCNTs shortened the setting time of DCPA and increased the compressive strength of DCPA cement from 11.09±1.85 MPa to 21.56±2.47 MPa. The cytocompatibility of the materials was investigated in vitro using the preosteoblast cell line MC3T3-E1. An increase of cell numbers was observed on both DCPA and DCPA-mMWCNTs. Scanning electron microscopy (SEM) results also revealed an obvious cell growth on the surface of the cements. Based on these results, DCPA-mMWCNTs composite cements can be considered as potential bone defect repair materials.
authors.affiliation: Department of Mechanical, Industrial and Manufacturing Engineering, The University of Toledo, Toledo, OH, USA.
authors.forename: Nariman Mansoori
authors.initials: NM
authors.lastname: Boroujeni
authors.forename: Huan
authors.initials: H
authors.lastname: Zhou
authors.forename: Timothy J F
authors.initials: TJ
authors.lastname: Luchini
authors.forename: Sarit B
authors.initials: SB
authors.lastname: Bhaduri
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001843:Bone Cements / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000494:pharmacology*; D002452:Cell Count; D002460:Cell Line; D019245:Compressive Strength / Q000187:drug effects; D017886:Durapatite / Q000737:chemistry; D055119:Elastic Modulus / Q000187:drug effects; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009985:Orthopedics; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D037742:Nanotubes, Carbon; D017886:Durapatite; C485829:calcium phosphate, dibasic, anhydrous
keywords: Bone cement; Monetite; Multi-walled carbon nanotube