title: The role of FOXP3 in disease progression in colorectal cancer patients.
abstract: The transcription factor forkhead box P3 (FOXP3) has been identified as a marker of CD4+CD25+regulatory T cells and is a key determinant of their immunosuppressive functions. FOXP3 has indeed been shown to limit antitumor immune responses during tumor progression. In addition, by expressing FOXP3, tumor cells may evade effector T-cell responses.
authors.affiliation: Department of Surgery I; Molecular Oncology and Immunology; University of Wuerzburg; Wuerzburg, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Grimmig
authors.forename: Mia
authors.initials: M
authors.lastname: Kim
authors.forename: Christoph-Thomas
authors.initials: CT
authors.lastname: Germer
authors.forename: Martin
authors.initials: M
authors.lastname: Gasser
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Waaga-Gasser
keywords: FOXP3; colorectal cancer; prognosis
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