title: Deletion of the 1p32 region is a major independent prognostic factor in young patients with myeloma: the IFM experience on 1195 patients.
abstract: Deletions of the 1p region appear as a pejorative prognostic factor in multiple myeloma patients (especially 1p22 and 1p32 deletions) but there is a lack of data on the real impact of 1p abnormalities on an important and homogeneous group of patients. To address this issue we studied by fluorescence in situ hybridization (FISH) the incidence and prognostic impact of 1p22 and 1p32 deletions in 1195 patients from the IFM (Institut Francophone du Myélome) cell collection. Chromosome 1p deletions were present in 23.3% of the patients (271): 15.1% (176) for 1p22 and 7.3% (85) for 1p32 regions. In univariate analyses, 1p22 and 1p32 appeared as negative prognostic factors for progression-free survival (PFS): 1p22: 19.8 months vs 33.6 months (P<0.001) and 1p32: 14.4 months vs 33.6 months (P<0.001); and overall survival (OS): 1p22: 44.2 months vs 96.8 months (P=0.002) and 1p32: 26.7 months vs 96.8 months (P<0.001). In multivariate analyses, 1p22 and 1p32 deletions still appear as independent negative prognostic factors for PFS and OS. In conclusion, our data show that 1p22 and 1p32 deletions are major negative prognostic factors for PFS and OS for patients with MM. We thus suggest that 1p32 deletion should be tested for all patients at diagnosis.
authors.affiliation: Unité de Génomique du Myélome, University Hospital, CRCT, INSERM U 1037, Université Paul Sabatier, Toulouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Hebraud
authors.affiliation: Service des Maladies du Sang, Hopital Claude Huriez, CHRU, Lille, France.
authors.forename: X
authors.initials: X
authors.lastname: Leleu
authors.affiliation: Service d'Epidémiologie, CHU Toulouse, Toulouse, France.
authors.forename: V
authors.initials: V
authors.lastname: Lauwers-Cances
authors.affiliation: Hématologie Clinique, Hôpital Purpan, Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Roussel
authors.affiliation: Department of Hematology, University Hospital, Dijon, France.
authors.forename: D
authors.initials: D
authors.lastname: Caillot
authors.affiliation: Department of Hematology, University Hospital, Bordeaux, France.
authors.forename: G
authors.initials: G
authors.lastname: Marit
authors.affiliation: Department of Hematology, University Hospital, Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Karlin
authors.affiliation: Department of Hematology, University Hospital, Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Hulin
authors.affiliation: Service d'Epidémiologie, CHU Toulouse, Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Gentil
authors.affiliation: CIC Inserm 0802, Centre Hospitalier Universitaire, Poitiers, France.
authors.forename: F
authors.initials: F
authors.lastname: Guilhot
authors.affiliation: Department of Hematology, University Hospital, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Garderet
authors.affiliation: Department of Hematology, University Hospital, Rennes, France.
authors.forename: T
authors.initials: T
authors.lastname: Lamy
authors.affiliation: Department of Hematology, University Hospital, Bobigny, France.
authors.forename: S
authors.initials: S
authors.lastname: Brechignac
authors.affiliation: Department of Hematology, University Hospital, Grenoble, France.
authors.forename: B
authors.initials: B
authors.lastname: Pegourie
authors.affiliation: Department of Hematology, University Hospital, St-Etienne, France.
authors.forename: J
authors.initials: J
authors.lastname: Jaubert
authors.affiliation: Department of Hematology, University Hospital, Angers, France.
authors.forename: M
authors.initials: M
authors.lastname: Dib
authors.affiliation: Department of Hematology, Institut Paoli Calmette, Marseille, France.
authors.forename: A-M
authors.initials: AM
authors.lastname: Stoppa
authors.affiliation: Department of Hematology, Centre Léon Bérard, Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Sebban
authors.affiliation: Department of Hematology, University Hospital, Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Fohrer
authors.affiliation: Department of Hematology, University Hospital, Besancon, France.
authors.forename: J
authors.initials: J
authors.lastname: Fontan
authors.affiliation: Department of Hematology, Centre Francois Baclesse, Caen, France.
authors.forename: C
authors.initials: C
authors.lastname: Fruchart
authors.affiliation: Department of Hematology, University Hospital, Caen, France.
authors.forename: M
authors.initials: M
authors.lastname: Macro
authors.affiliation: Department of Hematology, Departmental Hospital, Annecy, France.
authors.forename: F
authors.initials: F
authors.lastname: Orsini-Piocelle
authors.affiliation: Department of Hematology, Departmental Hospital, Avignon, France.
authors.forename: G
authors.initials: G
authors.lastname: Lepeu
authors.affiliation: Department of Hematology, Departmental Hospital, Toulon, France.
authors.forename: C
authors.initials: C
authors.lastname: Sohn
authors.affiliation: Unité de Génomique du Myélome, University Hospital, CRCT, INSERM U 1037, Université Paul Sabatier, Toulouse, France.
authors.forename: J
authors.initials: J
authors.lastname: Corre
authors.affiliation: Service des Maladies du Sang, Hopital Claude Huriez, CHRU, Lille, France.
authors.forename: T
authors.initials: T
authors.lastname: Facon
authors.affiliation: Department of Hematology, University Hospital, Nantes, France.
authors.forename: P
authors.initials: P
authors.lastname: Moreau
authors.affiliation: Hématologie Clinique, Hôpital Purpan, Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Attal
authors.affiliation: Unité de Génomique du Myélome, University Hospital, CRCT, INSERM U 1037, Université Paul Sabatier, Toulouse, France.
authors.forename: H
authors.initials: H
authors.lastname: Avet-Loiseau
mesh_terms: D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D015331:Cohort Studies; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis
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