title: Design of cell-matrix interactions in hyaluronic acid hydrogel scaffolds.
abstract: The design of hyaluronic acid (HA)-based hydrogel scaffolds to elicit highly controlled and tunable cell response and behavior is a major field of interest in developing tissue engineering and regenerative medicine applications. This review will begin with an overview of the biological context of HA, which is needed to better understand how to engineer cell-matrix interactions in the scaffolds via the incorporation of different types of signals in order to direct and control cell behavior. Specifically, recent methods of incorporating various bioactive, mechanical and spatial signals are reviewed, as well as novel HA modifications and crosslinking schemes with a focus on specificity.
authors.affiliation: Bioengineering Department, Los Angeles CA 90095.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lam
authors.affiliation: Chemical and Biomolecular Engineering Department, Los Angeles CA 90095.
authors.forename: Norman F
authors.initials: NF
authors.lastname: Truong
authors.affiliation: Chemical and Biomolecular Engineering Department, Los Angeles CA 90095.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Segura
mesh_terms: D000818:Animals; D002450:Cell Communication; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000378:metabolism*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000378:metabolism*; D015398:Signal Transduction; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006820:Hyaluronic Acid
keywords: Hyaluronic acid; Hydrogel; Scaffold; Tissue engineering
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