title: An isolate alpha-fetoprotein producing gastric cancer liver metastasis emerged in a patient previously affected by radiation induced liver disease.
abstract: We report a case of an isolated hepatic neoplasia which originated in a site of the liver previously affected by radiation induced liver disease (RILD) in a patient resected for gastric cancer and referred to us for high serum alpha-fetoprotein (AFP) levels. This case challenged us in distiguishing, even histologically, between primary liver cancer and AFP producing gastric cancer metastasis. Only a panel of immunohistochemical markers allowed the definitive diagnosis of liver metastasis of endodermal stem cell-derived and AFP producing gastric cancer. We discuss the criteria for a differential diagnosis, as well as the possible link between RILD and emergence of liver neoplasia.
authors.affiliation: Vincenzo Cardinale, Domenico Alvaro, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00185 Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cardinale
authors.forename: Gianmaria
authors.initials: G
authors.lastname: De Filippis
authors.forename: Alessandro
authors.initials: A
authors.lastname: Corsi
authors.forename: Augusto
authors.initials: A
authors.lastname: La Penna
authors.forename: Michele
authors.initials: M
authors.lastname: Rossi
authors.forename: Carlo
authors.initials: C
authors.lastname: Catalano
authors.forename: Paolo
authors.initials: P
authors.lastname: Bianco
authors.forename: Adriano
authors.initials: A
authors.lastname: De Santis
authors.forename: Domenico
authors.initials: D
authors.lastname: Alvaro
keywords: Alpha-fetoprotein producing gastric cancer; Hepatoid adenocarcinoma; Liver metastasization; Radiation induced liver disease
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