title: Resonance Rayleigh scattering, frequency doubling scattering and absorption spectrum of the interaction for mebendazole with 12-tungstophosphoric acid and its analytical applications.
abstract: The interaction of mebendazole (MBZ) with 12-tungstophosphoric acid (TP) has been investigated by using resonance Rayleigh scattering (RRS) and frequency doubling scattering (FDS) combining with absorption spectrum. In pH 1.0 HCl medium, MBZ reacted with TP to form 3:1 ion-association complex. As a result, not only the spectrum of absorption was changed, but also the intensities of RRS and FDS were enhanced greatly. The maximum RRS, FDS and absorption wavelengths are located at 372, 392 and 260 nm, respectively. The increments of scattering intensity (ΔI) and absorption (ΔA) are directly proportional to the concentrations of MBZ in certain ranges. The detection limits (3σ) of RRS, FDS and absorption are 0.56, 0.86 and 130.16 ng/mL, respectively. The sensitivity of RRS method is higher than FDS and absorption methods. The optimum conditions of RRS method and the influence factors were discussed in the paper, in addition, the structure of ion-association complex and the reaction mechanism were investigated. Based on the ion-association reaction and its spectral response, the rapid, simple and sensitive RRS method for the determination of MBZ has been developed.
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Chongqing, Beibei 400715, China.
authors.forename: Fengling
authors.initials: F
authors.lastname: Tian
authors.forename: Jidong
authors.initials: J
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Shang
authors.initials: S
authors.lastname: Zhou
authors.forename: Gengyang
authors.initials: G
authors.lastname: Yao
mesh_terms: D000969:Antinematodal Agents / Q000032:analysis*; D005470:Fluorometry / Q000379:methods; D057230:Limit of Detection; D008463:Mebendazole / Q000032:analysis*; D010756:Phosphoric Acids / Q000737:chemistry*; D012542:Scattering, Radiation; D050257:Tubulin Modulators / Q000032:analysis*; D017973:Tungsten Compounds / Q000737:chemistry*
chemical_list: C519880:12-tungstophosphoric acid; D000969:Antinematodal Agents; D010756:Phosphoric Acids; D050257:Tubulin Modulators; D017973:Tungsten Compounds; D008463:Mebendazole
keywords: 12-Tungstophosphoric acid (TP); Frequency doubling scattering (FDS); Mebendazole (MBZ); Resonance Reyleigh scattering (RRS)