title: Cued recall measure predicts the progression of gray matter atrophy in patients with amnesic mild cognitive impairment.
abstract: Amnesic mild cognitive impairment (aMCI) is a heterogeneous syndrome that could be subdivided into distinct neuropsychological variants. To investigate relationships between the neuropsychological profile of memory impairment at baseline and the neuroimaging pattern of grey matter (GM) loss over 18 months, we performed a prospective volumetric brain study on 31 aMCI patients and 29 matched controls. All subjects were tested at baseline using a standardized neuropsychological battery, which included the Free and Cued Selective Recall Reminding Test (FCSRT) for the assessment of verbal declarative memory. Over 18 months, patients with impaired free recall but normal total recall (high index of cueing) on the FCSRT developed subcortical and frontal GM loss, while patients with impaired free and total recall (low index of cueing) developed GM atrophy within the left anterior and lateral temporal lobe. In summary, cued recall deficits are associated with a progression of atrophy that closely parallels the spatiotemporal distribution of neurofibrillary degeneration in early Alzheimer's disease (AD), indicating possible AD pathological changes.
authors.affiliation: Service de Neurologie et de Neuropsychologie, CHU Timone, APHM, Marseille, France.
authors.forename: Lejla
authors.initials: L
authors.lastname: Koric
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ranjeva
authors.forename: Olivier
authors.initials: O
authors.lastname: Felician
authors.forename: Maxime
authors.initials: M
authors.lastname: Guye
authors.forename: Francesca
authors.initials: F
authors.lastname: de Anna
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Soulier
authors.forename: Mira
authors.initials: M
authors.lastname: Didic
authors.forename: Mathieu
authors.initials: M
authors.lastname: Ceccaldi
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000523:psychology; D000647:Amnesia / Q000473:pathology / Q000523:psychology; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000473:pathology* / Q000523:psychology*; D003463:Cues; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology; D059906:Neuroimaging; D009483:Neuropsychological Tests; D013702:Temporal Lobe / Q000473:pathology