title: First polymer "ruthenium-cyclopentadienyl" complex as potential anticancer agent.
abstract: d-glucose end-capped polylactide ruthenium cyclopentadienyl complex (RuPMC) was newly synthesized by a straightforward method. RuPMC was tested against human MCF7 and MDAMB231 breast and A2780 ovarian adenocarcinoma revealing IC50 values in the micromolar range. A pH dependent hydrolysis is advanced by preliminary UV-visible spectroscopy. Cellular distribution studies showed that RuPMC is predominantly found in the nucleus and in the membrane. Data suggest potential application of RuPMC as a new drug delivery system for Ru(II)Cp compounds.
authors.affiliation: Centro de Ciências Moleculares e Materiais, Departamento de Química e Bioquímica Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal. Electronic address: amvalente@fc.ul.pt.
authors.forename: Andreia
authors.initials: A
authors.lastname: Valente
authors.forename: Maria Helena
authors.initials: MH
authors.lastname: Garcia
authors.forename: Fernanda
authors.initials: F
authors.lastname: Marques
authors.forename: Yong
authors.initials: Y
authors.lastname: Miao
authors.forename: Cyril
authors.initials: C
authors.lastname: Rousseau
authors.forename: Philippe
authors.initials: P
authors.lastname: Zinck
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D009942:Organometallic Compounds; D011108:Polymers; C583564:eta5-cyclopentadienyl(2,2'-bipyridyl)(triphenylphosphane)ruthenium(II); D012428:Ruthenium
keywords: Anticancer agent; Drug delivery; Polylactide; Ruthenium cyclopentadienyl