title: Nerve allografts and conduits in peripheral nerve repair.
abstract: Since the last update on nerve conduits and allograft in 2000, investigations have established the efficacy of these alternatives to autograft in the repair of small sensory neural gaps. However, limited insights into the biology of the regenerating nerve continue to preclude intelligent conduit design. Ongoing discoveries in neuroscience and biomaterial engineering hold promise for the eventual development of allograft and conduits with potential of surpassing nerve autografts in clinical efficacy. In this review, we summarize the history, recent advances, and emerging developments in nerve conduits and allograft.
authors.affiliation: Department of Orthopaedic Surgery, University of California Irvine, 2226 Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Lin
authors.forename: Givenchy
authors.initials: G
authors.lastname: Manzano
authors.forename: Ranjan
authors.initials: R
authors.lastname: Gupta
mesh_terms: D064591:Allografts; D001672:Biocompatible Materials; D002474:Cell-Free System / Q000637:transplantation; D048271:Chitosan; D024042:Collagen Type I; D005337:Fibrin; D048091:Guided Tissue Regeneration / Q000379:methods; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008866:Microsurgery / Q000639:trends; D009416:Nerve Regeneration; D019635:Neurosurgical Procedures / Q000379:methods* / Q000639:trends; D059348:Peripheral Nerve Injuries / Q000601:surgery*; D010525:Peripheral Nerves / Q000033:anatomy & histology / Q000503:physiopathology / Q000637:transplantation*; D011091:Polyesters; D011100:Polyglycolic Acid; D019736:Prostheses and Implants; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous; D058017:Vascular Grafting
chemical_list: D001672:Biocompatible Materials; D024042:Collagen Type I; D011091:Polyesters; D011100:Polyglycolic Acid; C062968:lactide-caprolactone copolymer; D005337:Fibrin; D048271:Chitosan
keywords: Allograft; Nerve conduit; Peripheral nerve injury; Peripheral nerve repair