title: Anti-correlated cortical networks of intrinsic connectivity in the rat brain.
abstract: In humans, resting-state blood oxygen level-dependent (BOLD) signals in the default mode network (DMN) are temporally anti-correlated with those from a lateral cortical network involving the frontal eye fields, secondary somatosensory and posterior insular cortices. Here, we demonstrate the existence of an analogous lateral cortical network in the rat brain, extending laterally from anterior secondary sensorimotor regions to the insular cortex and exhibiting low-frequency BOLD fluctuations that are temporally anti-correlated with a midline "DMN-like" network comprising posterior/anterior cingulate and prefrontal cortices. The primary nexus for this anti-correlation relationship was the anterior secondary motor cortex, close to regions that have been identified with frontal eye fields in the rat brain. The anti-correlation relationship was corroborated after global signal removal, underscoring this finding as a robust property of the functional connectivity signature in the rat brain. These anti-correlated networks demonstrate strong anatomical homology to networks identified in human and monkey connectivity studies, extend the known preserved functional connectivity relationships between rodent and primates, and support the use of resting-state functional magnetic resonance imaging as a translational imaging method between rat models and humans.
authors.affiliation: 1 Lilly Research Laboratories , Eli Lilly and Company, Indianapolis, Indiana.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Schwarz
authors.forename: Natalia
authors.initials: N
authors.lastname: Gass
authors.forename: Alexander
authors.initials: A
authors.lastname: Sartorius
authors.forename: Celine
authors.initials: C
authors.lastname: Risterucci
authors.forename: Michael
authors.initials: M
authors.lastname: Spedding
authors.forename: Esther
authors.initials: E
authors.lastname: Schenker
authors.forename: Andreas
authors.initials: A
authors.lastname: Meyer-Lindenberg
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weber-Fahr
mesh_terms: D000818:Animals; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000098:blood supply / Q000502:physiology*; D006179:Gyrus Cinguli / Q000098:blood supply / Q000502:physiology*; D006624:Hippocampus / Q000098:blood supply / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D010100:Oxygen / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012146:Rest / Q000502:physiology
chemical_list: D010100:Oxygen
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