title: Culcitiolides E-J, six new eremophilane-type sesquiterpene derivatives from Senecio culcitioides.
abstract: Culcitiolides E-J (1-6), six new eremophilane-type sesquiterpenes, were isolated from the stem of Senecio culcitioides SCH. BIP. (Asteraceae). The structures were determined by detailed NMR spectral analysis. The inhibitory activities of these compounds against nuclear factor κB (NF-κB)-dependent gene expression were assessed. Culcitiolides E, H, and I potently inhibited NF-κB-induced gene expression at 20 µM.
authors.affiliation: Department of Biological Chemistry, Faculty of Science, Okayama University of Science, Okayama 700–0005, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Mitsui
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Mikiko
authors.initials: M
authors.lastname: Kawai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kido
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tani
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takaoka
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Matsuura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nozaki
mesh_terms: D005786:Gene Expression Regulation / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012674:Senecio / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D016328:NF-kappa B; D009281:Naphthalenes; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C018286:eremophilane compounds