title: Prevalence of congenital toxoplasmosis among a series of Turkish women.
abstract: BACKGROUND
  Toxoplasma gondii infection during pregnancy causes congenital malformations. Pregnant women should be screened for this infection since it is preventable and treatable.
  
  
  OBJECTIVE
  To study the sero prevalence of Toxoplasma gondii infection among pregnant women living in lzmir, Turkey.
  
  
  METHODS
  A blood sample was obtained from 4651 women aged between 15 and 45 years, during their first trimester of pregnancy. IgM and IgG antibodies against Toxoplasma gondii were measured using an ELISA assay. Among women with both IgG and IgM antibodies positive, an IgG avidity test was performed, using a VIDAS kit.
  
  
  RESULTS
  IgG antibodies were positive in 1871 (39.9%) participants. Of these, 48 (2.5%) also had positive IgM antibodies. In 41 of these 48 women, the IgG avidity test was performed and only one woman had a low avidity. This woman was treated with Spiramycin. Her offspring had an intrauterine growth retardation and oligohydramnios. A chorioretinitis was diagnosed in the offspring of other woman with both antibodies positive.
  
  
  CONCLUSIONS
  In this series, the prevalence of congenital toxoplasmosis was low. However, women with positive antibodies against Toxoplasma Gondii should be further studied and followed during their pregnancy.
authors.affiliation: Seferihisar Necat Hepkon State Hospital, Izmir, Turkey. drahmetuysal@hotmail.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Uysal
authors.forename: Mete
authors.initials: M
authors.lastname: Cüce
authors.forename: Cüneyt E
authors.initials: CE
authors.lastname: Tañer
authors.forename: Fatma
authors.initials: F
authors.lastname: Uysal
authors.forename: Sabri
authors.initials: S
authors.lastname: Atalay
authors.forename: Basak
authors.initials: B
authors.lastname: Göl
authors.forename: Sükran
authors.initials: S
authors.lastname: Köse
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008875:Middle Aged; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000453:epidemiology*; D011261:Pregnancy Trimester, First; D015995:Prevalence; D014125:Toxoplasmosis, Congenital / Q000097:blood / Q000453:epidemiology*; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M