title: Stimulation-evoked dopamine release in the nucleus accumbens following cocaine administration in rats perinatally exposed to polychlorinated biphenyls.
abstract: Exposure to polychlorinated biphenyls (PCBs) alters brain dopamine (DA) concentrations and DA receptor/transporter function, suggesting the reinforcing properties of drugs of abuse acting on the DA system may be affected by PCB exposure. Female Long-Evans rats were orally exposed to 0, 3, or 6 mg/kg/day PCBs from 4 weeks prior to breeding until litters were weaned on postnatal day 21. In vivo fixed potential amperometry (FPA) was used in adult anesthetized offspring to determine whether perinatal PCB exposure altered (1) presynaptic DA autoreceptor (DAR) sensitivity, (2) electrically evoked nucleus accumbens (NAc) DA efflux following administration of cocaine, and (3) the rate of depletion of presynaptic DA stores. One adult male and female littermate were tested using FPA following a single injection of cocaine (20 mg/kg ip), whereas a second adult male and female littermate were tested following the last of seven daily cocaine injections of the same dose. The carbon fiber recording microelectrode was positioned in the NAc core, and DA oxidation currents (i.e., DA release) evoked by brief stimulation of the medial forebrain bundle (MFB) were quantified before and after administration of cocaine. PCB-exposed rats exhibited enhanced stimulation-evoked DA release (relative to baseline) following a single injection of cocaine. Although nonexposed controls exhibited typical DA sensitization following repeated cocaine administration, this effect was attenuated in PCB-exposed rats. In addition, DAR sensitivity was higher (males only), and the rate of depletion of presynaptic DA stores was greater in PCB-exposed animals relative to nonexposed controls. These results indicate that perinatal PCB exposure can modify DA synaptic transmission in the NAc in a manner previously shown to alter the reinforcing properties of cocaine.
authors.affiliation: Department of Psychology, University of Memphis, Memphis, Tennessee 38152.
authors.forename: Jenna R
authors.initials: JR
authors.lastname: Fielding
authors.forename: Tiffany D
authors.initials: TD
authors.lastname: Rogers
authors.forename: Abby E
authors.initials: AE
authors.lastname: Meyer
authors.forename: Mellessa M
authors.initials: MM
authors.lastname: Miller
authors.forename: Jenna L
authors.initials: JL
authors.lastname: Nelms
authors.forename: Guy
authors.initials: G
authors.lastname: Mittleman
authors.forename: Charles D
authors.initials: CD
authors.lastname: Blaha
authors.forename: Helen J K
authors.initials: HJ
authors.lastname: Sable
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017660:Autoreceptors / Q000187:drug effects / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D003042:Cocaine / Q000633:toxicity*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005260:Female; D008297:Male; D018811:Maternal Exposure; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors; D014886:Weaning
chemical_list: D017660:Autoreceptors; D000697:Central Nervous System Stimulants; D011954:Receptors, Dopamine; D011078:Polychlorinated Biphenyls; D003042:Cocaine; D004298:Dopamine
keywords: behavioral sensitization.; neurotoxicology
references.citation: Toxicology. 2001 Feb 21;159(1-2):11-21
references.pmid: 11250051
references.citation: Neurotoxicol Teratol. 2011 Mar-Apr;33(2):255-62
references.pmid: 20933596
references.citation: Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3137-46
references.pmid: 18640920
references.citation: Neurotoxicology. 1997;18(3):857-67
references.pmid: 9339832
references.citation: Toxicol Appl Pharmacol. 1999 Dec 15;161(3):274-82
references.pmid: 10620485
references.citation: Neurosci Biobehav Rev. 2006;30(2):215-38
references.pmid: 16099045
references.citation: Neuropharmacology. 1987 Aug;26(8):1053-9
references.pmid: 3658117
references.citation: Neurotoxicology. 1989 Winter;10(4):757-64
references.pmid: 2562550
references.citation: Neurotoxicol Teratol. 1998 Jul-Aug;20(4):391-400
references.pmid: 9697965
references.citation: Acta Paediatr Suppl. 1999 May;88(429):55-63
references.pmid: 10419233
references.citation: Neurotoxicol Teratol. 1997 Nov-Dec;19(6):429-34
references.pmid: 9392778
references.citation: Toxicol Sci. 2004 Aug;80(2):288-95
references.pmid: 15115888
references.citation: NIDA Res Monogr. 1994;145:1-18
references.pmid: 8742805
references.citation: J Neurosci. 2002 Jul 15;22(14):6272-81
references.pmid: 12122086
references.citation: Environ Health Perspect. 1993 Apr;100:259-68
references.pmid: 8354174
references.citation: Toxicology. 1994 Jan 26;86(1-2):71-87
references.pmid: 8134924
references.citation: Eur J Neurosci. 2006 Feb;23(4):1005-14
references.pmid: 16519665
references.citation: Environ Health Perspect. 2006 Dec;114(12):1923-9
references.pmid: 17185286
references.citation: Eur J Pharmacol. 2003 Oct 31;479(1-3):139-52
references.pmid: 14612145
references.citation: Biochem Pharmacol. 2009 Dec 1;78(11):1401-11
references.pmid: 19615345
references.citation: Toxicol Appl Pharmacol. 2002 Jan 15;178(2):71-81
references.pmid: 11814327
references.citation: Neuroreport. 2008 Jun 11;19(9):991-5
references.pmid: 18521007
references.citation: Neurotoxicol Teratol. 2009 May-Jun;31(3):149-58
references.pmid: 19344642
references.citation: Crit Rev Toxicol. 1996 Nov;26(6):709-37
references.pmid: 8958469
references.citation: J Pharm Pharmacol. 1972 Sep;24(9):744-7
references.pmid: 4404084
references.citation: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4029-34
references.pmid: 9520487
references.citation: Environ Health Perspect. 2003 Oct;111(13):1670-7
references.pmid: 14527849
references.citation: Neurotoxicol Teratol. 2005 Nov-Dec;27(6):771-80
references.pmid: 16198536
references.citation: Toxicol Sci. 2006 Aug;92(2):490-9
references.pmid: 16702228
references.citation: J Pediatr. 1990 Jan;116(1):38-45
references.pmid: 2104928
references.citation: J Pediatr. 2003 Dec;143(6):780-8
references.pmid: 14657828
references.citation: Toxicol Sci. 2007 May;97(1):128-39
references.pmid: 17324953
references.citation: Arch Toxicol. 2011 Oct;85(10):1281-94
references.pmid: 21331603
references.citation: J Neurochem. 1999 Jan;72(1):148-56
references.pmid: 9886065
references.citation: J Neurosci Methods. 2001 Dec 15;112(2):163-72
references.pmid: 11716951
references.citation: Behav Brain Res. 1998 Jul;94(1):213-24
references.pmid: 9708851
references.citation: Arch Toxicol Suppl. 1994;16:128-37
references.pmid: 8192574
references.citation: J Toxicol Environ Health A. 2006 Jan 8;69(1-2):21-35
references.pmid: 16291560
references.citation: Neurotoxicol Teratol. 2013 Jul-Aug;38:6-12
references.pmid: 23623962
references.citation: Synapse. 2008 Jul;62(7):544-50
references.pmid: 18435424
references.citation: Methods. 2004 Aug;33(4):322-9
references.pmid: 15183181
references.citation: Toxicol Appl Pharmacol. 1990 Oct;106(1):136-44
references.pmid: 2123577
references.citation: Toxicol Sci. 2005 Dec;88(2):400-11
references.pmid: 16177234
references.citation: Eur J Neurosci. 2000 Aug;12(8):2985-92
references.pmid: 10971639
references.citation: Science. 2005 Mar 4;307(5714):1476-9
references.pmid: 15746431
references.citation: Neuroscience. 1994 Oct;62(3):647-54
references.pmid: 7870296
references.citation: Behav Cogn Neurosci Rev. 2002 Dec;1(4):281-96
references.pmid: 17712985
references.citation: J Pharmacol Exp Ther. 1999 Apr;289(1):266-77
references.pmid: 10087014
references.citation: Toxicol Appl Pharmacol. 1997 Sep;146(1):95-103
references.pmid: 9299601
references.citation: J Neurochem. 2001 Dec;79(5):1070-9
references.pmid: 11739621
references.citation: AAPS J. 2005 Dec 20;7(4):E847-51
references.pmid: 16594636
references.citation: Nat Neurosci. 2011 Jul 10;14(8):1033-8
references.pmid: 21743470
references.citation: Acta Physiol Scand Suppl. 1971;371:35-44
references.pmid: 4112831
references.citation: Neurotoxicol Teratol. 2006 Sep-Oct;28(5):548-56
references.pmid: 16930942
references.citation: Toxicol Lett. 2004 Mar 14;148(1-2):29-40
references.pmid: 15019086
references.citation: Biochem Pharmacol. 2008 Sep 1;76(5):569-81
references.pmid: 18555207
references.citation: Curr Opin Pharmacol. 2009 Feb;9(1):65-73
references.pmid: 19162544
references.citation: J Neurosci. 1998 Mar 15;18(6):2231-8
references.pmid: 9482807
references.citation: Toxicol Appl Pharmacol. 1999 Aug 1;158(3):231-43
references.pmid: 10438656
references.citation: Environ Health Perspect. 2002 Nov;110(11):1113-7
references.pmid: 12417482
references.citation: Neurobehav Toxicol Teratol. 1986 Mar-Apr;8(2):131-8
references.pmid: 3086763
references.citation: Toxicology. 1991 Feb;66(2):145-63
references.pmid: 2014516
references.citation: J Pediatr. 1984 Aug;105(2):315-20
references.pmid: 6431068