title: Prevalence and related risk-factors of peripheral neuropathy in children with insulin-dependent diabetes mellitus.
abstract: BACKGROUND
  Diabetes mellitus (DM) is a common metabolic disorder that can cause various complications including, peripheral neuropathy (PNP). Some possible risk-factors such as blood glucose level, hyperglycemia, duration of diabetes, and lipid profiles are assumed to be important in diabetic PNP incidence. The aim of this study is to evaluate the prevalence and possible risk-factors of PNP in children with insulin dependent DM.
  
  
  METHODS
  Among diabetic children, 146 patients (up to 18-years old) were evaluated in this cross-sectional study. All patients were examined for signs and symptoms of neuropathy and nerve conduction studies were performed. Blood level of glucose and lipid profiles were also tested. The relation between variables was compared by independent t-test and logistic regression test.
  
  
  RESULTS
  The mean age of diabetic children was 11.9 ± 3.3 years whereas mean diabetes duration was 3.8 ± 2.9 years. PNP was detected in 40 patients (27.4%) that 62.5% of them have subclinical and 37.5% have clinical neuropathy. According to logistic regression analysis, duration of diabetes was the most important factor in prevalence of PNP (5.7 ± 3.5 and 3.1 ± 2.5 years in patients with and without neuropathy respectively, P < 0.001, 95% confidence interval [1.15-1.54]).
  
  
  CONCLUSIONS
  As most of the patients had subclinical PN, neurological assessment is recommended to detect subclinical neuropathy in asymptomatic type 1 diabetic children and it seems that the best way to prevent this complication is still rigid blood glucose control and periodic evaluations.
authors.affiliation: Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Nasibeh
authors.initials: N
authors.lastname: Hasani
authors.forename: Saeid
authors.initials: S
authors.lastname: Khosrawi
authors.forename: Mahin
authors.initials: M
authors.lastname: Hashemipour
authors.forename: Mania
authors.initials: M
authors.lastname: Haghighatiyan
authors.forename: Zahra
authors.initials: Z
authors.lastname: Javdan
authors.forename: Mohamad Hadi
authors.initials: MH
authors.lastname: Taheri
authors.forename: Roya
authors.initials: R
authors.lastname: Kelishadi
authors.forename: Massoud
authors.initials: M
authors.lastname: Amini
authors.forename: Reihaneh
authors.initials: R
authors.lastname: Barekatein
keywords: Diabetes mellitus; peripheral neuropathy; prevalence; risk factors; type 1
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