title: Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy.
abstract: Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the corresponding mRNAs, may further enhance vaccine-induced antitumor responses.
authors.affiliation: Department of Tumor Immunology; Nijmegen Centre for Molecular Life Sciences; Radboud University Nijmegen Medical Centre; Nijmegen, the Netherlands.
authors.forename: Gerty
authors.initials: G
authors.lastname: Schreibelt
authors.forename: Kalijn F
authors.initials: KF
authors.lastname: Bol
authors.forename: Erik Hjg
authors.initials: EH
authors.lastname: Aarntzen
authors.forename: Winald R
authors.initials: WR
authors.lastname: Gerritsen
authors.forename: Cornelis Ja
authors.initials: CJ
authors.lastname: Punt
authors.forename: Carl G
authors.initials: CG
authors.lastname: Figdor
authors.forename: I Jolanda M
authors.initials: IJ
authors.lastname: de Vries
keywords: cancer immunotherapy; dendritic cell vaccination; helper T cells; metastatic melanoma
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