title: Combined effect of PLGA and curcumin on wound healing activity.
abstract: Wound healing is a complex process involving many interdependent and overlapping sequences of physiological actions. The application of exogenous lactate released from poly (lactic-co-glycolic acid) (PLGA) polymer accelerated angiogenesis and wound healing processes. Curcumin is a well-known topical wound healing agent for both normal and diabetic-impaired wounds. Hence, we hypothesized that the PLGA nanoparticles encapsulating curcumin could much potentially accelerate the wound healing. In a full thickness excisional wound healing mouse model, PLGA-curcumin nanoparticles showed a twofold higher wound healing activity compared to that of PLGA or curcumin. Histology and RT-PCR studies confirmed that PLGA-curcumin nanoparticles exhibited higher re-epithelialization, granulation tissue formation and anti-inflammatory potential. PLGA nanoparticles offered various benefits for the encapsulated curcumin like protection from light degradation, enhanced water solubility and showed a sustained release of curcumin over a period of 8 days. In conclusion, we demonstrated the additive effect of lactic acid from PLGA and encapsulated curcumin for the active healing of wounds.
authors.affiliation: Pharmaceutics and Drug Delivery, Louvain Drug Research Institute, Université catholique de Louvain, 1200 Brussels, Belgium.
authors.forename: Kiran Kumar
authors.initials: KK
authors.lastname: Chereddy
authors.forename: Régis
authors.initials: R
authors.lastname: Coco
authors.forename: Patrick B
authors.initials: PB
authors.lastname: Memvanga
authors.forename: Bernard
authors.initials: B
authors.lastname: Ucakar
authors.forename: Anne
authors.initials: A
authors.lastname: des Rieux
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Vandermeulen
authors.forename: Véronique
authors.initials: V
authors.lastname: Préat
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003094:Collagen / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry; D005260:Female; D005979:Glutathione Peroxidase / Q000235:genetics; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D019344:Lactic Acid / Q000008:administration & dosage* / Q000737:chemistry; D051379:Mice; D016328:NF-kappa B / Q000235:genetics; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009195:Peroxidase / Q000378:metabolism; D011100:Polyglycolic Acid / Q000008:administration & dosage* / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012867:Skin / Q000293:injuries / Q000378:metabolism; D013778:Tetrazolium Salts / Q000378:metabolism; D013844:Thiazoles / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D013778:Tetrazolium Salts; D013844:Thiazoles; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003094:Collagen; D007770:L-Lactate Dehydrogenase; D009195:Peroxidase; D005979:Glutathione Peroxidase; C022616:thiazolyl blue; D003474:Curcumin
keywords: Curcumin; Drug delivery; Nanoparticles; Poly (lactic-co-glycolic acid); Skin wound healing