title: Oxygen plasma functionalization of parylene C coating for implants surface: nanotopography and active sites for drug anchoring.
abstract: The effect of oxygen plasma treatment (t=0.1-60 min, pO2=0.2 mbar, P=50 W) of parylene C implant surface coating was investigated in order to check its influence on morphology (SEM, AFM observations), chemical composition (XPS analysis), hydrophilicity (contact angle measurements) and biocompatibility (MG-63 cell line and Staphylococcus aureus 24167 DSM adhesion screening). The modification procedure leads to oxygen insertion (up to 20 at.%) into the polymer matrix and together with surface topography changes has a dramatic impact on wettability (change of contact angle from θ=78±2 to θ=33±1.9 for unmodified and 60 min treated sample, respectively). As a result, the hydrophilic surface of modified parylene C promotes MG-63 cells growth and at the same time does not influence S. aureus adhesion. The obtained results clearly show that the plasma treatment of parylene C surface provides suitable polar groups (C=O, C-O, O-C=O, C-O-O and O-C(O)-O) for further development of the coating functionality.
authors.affiliation: Faculty of Chemistry, Jagiellonian University, ul. Ingardena 3, PL-30060 Krakow, Poland. golda@chemia.uj.edu.pl
authors.forename: M
authors.initials: M
authors.lastname: Gołda
authors.forename: M
authors.initials: M
authors.lastname: Brzychczy-Włoch
authors.forename: M
authors.initials: M
authors.lastname: Faryna
authors.forename: K
authors.initials: K
authors.lastname: Engvall
authors.forename: A
authors.initials: A
authors.lastname: Kotarba
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects; D020134:Catalytic Domain; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010100:Oxygen / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D058626:Plasma Gases / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D019736:Prostheses and Implants; D013211:Staphylococcus aureus / Q000166:cytology / Q000187:drug effects; D013499:Surface Properties; D014992:Xylenes / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D004364:Pharmaceutical Preparations; D058626:Plasma Gases; D011108:Polymers; D014992:Xylenes; C011055:parylene; D010100:Oxygen
keywords: Implant surface; MG-63 cells; Oxygen plasma treatment; Parylene C; Staphylococcus aureus