title: The cytological grading of malignant neoplasms of the breast and its correlation with the histological grading.
abstract: OBJECTIVE
  Breast carcinoma is one of the leading causes of malignancy in females. The diagnosis of breast carcinoma is often made by fine needle aspiration cytology. Nuclear grading is an important prognostic factor. It is important to grade breast carcinomas, which will provide valuable information to the treating oncologists to plan their management. The purpose of this study was to compare the cytological grading and typing with the histological grading and typing and the regional lymph node metastasis.
  
  
  METHODS
  This retrospective and prospective study was done on 60 cases with malignant and suspicious diagnoses on FNAC, which had histopathological correlations, from January 2004 to December 2007. The cytological grading was done by Robinson's Method and the histopathological grading was done by the modified Scarff Bloom Richardson method. Cytological and histological typings were also done. The statistical analysis was done by using the SPSS software: The Chi square test was used and a contingency tale analysis (cross tabs procedure) was also done.
  
  
  RESULTS
  The cytohistological grading correlation was accurate in 7 cases (100%) of grade 1, 22 cases (71%) of grade 3 and 9 cases (42.9%) of grade 2 cancers. The accuracy was 62.7% (P < 0.001). A higher cytological grade was associated with a nodal metastasis. (cc : 0.399, P < .006) The cytological typing was accurate in 44 cases out of the 60 cases.
  
  
  CONCLUSIONS
  The cytological grade correlated well with the histological grading accuracy (62.7%) and a higher grade was associated with a nodal metastasis (P < 0.006), Hence the cytological grading and typing should be routinely incorporated in the cytology reports and they can be of great value in guiding the choice of the treatment protocols.
authors.affiliation: Assistant Professor, Department of Pathology, Mysore Medical College & Research Institute , Mysore, Karnataka, India .
authors.forename: Vidya
authors.initials: V
authors.lastname: Vasudev
authors.forename: Rangaswamy
authors.initials: R
authors.lastname: R
authors.forename: Geethamani
authors.initials: G
authors.lastname: V
keywords: Breast Carcinoma; Cytological Grading; Cytological Typing; Nodal Metastasis
references.citation: Acta Cytol. 1997 Mar-Apr;41(2):302-6
references.pmid: 9100758
references.citation: Indian J Pathol Microbiol. 1991 Oct;34(4):259-64
references.pmid: 1667922
references.citation: Acta Cytol. 1997 Mar-Apr;41(2):313-20
references.pmid: 9100760
references.citation: Indian J Pathol Microbiol. 1998 Oct;41(4):397-401
references.pmid: 9866898
references.citation: Lancet. 1994 Apr 16;343(8903):947-9
references.pmid: 7909010
references.citation: Acta Cytol. 1993 May-Jun;37(3):361-6
references.pmid: 8498137
references.citation: Am J Clin Pathol. 1995 Feb;103(2):195-8
references.pmid: 7856562
references.citation: Acta Cytol. 1997 May-Jun;41(3):701-4
references.pmid: 9167687
references.citation: Indian J Pathol Microbiol. 1989 Apr;32(2):133-7
references.pmid: 2807438
references.citation: J Indian Med Assoc. 1995 Oct;93(10):372-4
references.pmid: 9053408
references.citation: Acta Cytol. 2005 Mar-Apr;49(2):149-53
references.pmid: 15839618
references.citation: Acta Cytol. 2000 Jul-Aug;44(4):587-91
references.pmid: 10934952
references.citation: Acta Cytol. 2001 Jul-Aug;45(4):658-9
references.pmid: 11480737
references.citation: Acta Cytol. 2005 Nov-Dec;49(6):605-10
references.pmid: 16450899
references.citation: Cancer. 1995 Jan 1;75(1 Suppl):406-21
references.pmid: 8001011
references.citation: Indian J Pathol Microbiol. 2006 Apr;49(2):199-202
references.pmid: 16933714
references.citation: Histopathology. 1991 Nov;19(5):403-10
references.pmid: 1757079
references.citation: Indian J Pathol Microbiol. 2006 Apr;49(2):208-13
references.pmid: 16933716