title: Investigation on the properties of linear PLA-poloxamer and star PLA-poloxamine copolymers for temporary biomedical applications.
abstract: The objective of this work was to develop and study new biodegradable thermoplastics with improved mechanical properties for potential use as temporary implantable biomaterials. Linear poloxamer and star-shaped poloxamine have been used as macroinitiators for the ring-opening polymerization (ROP) of lactide to yield high molecular weight PLA-based thermoplastic block copolymers. The influence of the nature of the macroinitiator, PLA crystallinity and initial molecular weight on the copolymers properties was investigated by performing a 7-week degradation test in PBS. The evaluation of water uptakes and molecular weights during the degradation pointed out an early hydrolytic degradation of the 100-kg∙mol(-1) copolymers compared to the 200-kg∙mol(-1) ones (molecular weight decrease of ca. 40% and 20%, respectively). A dramatic loss of tensile mechanical properties was also observed for the 100-kg∙mol(-1) copolymers, whereas the 200-kg∙mol(-1) copolymers showed stable or even slightly improved properties with Young's moduli around 500 MPa and yield strains around 3% to 4%. Finally, the cytocompatibility of the more stable 200 kg∙mol(-1) copolymers was confirmed by murine mesenchymal stem cells (MSCs) culture.
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2-Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier, 34093, France.
authors.forename: Adrien
authors.initials: A
authors.lastname: Leroy
authors.forename: Coline
authors.initials: C
authors.lastname: Pinese
authors.forename: Claire
authors.initials: C
authors.lastname: Bony
authors.forename: Xavier
authors.initials: X
authors.lastname: Garric
authors.forename: Danièle
authors.initials: D
authors.lastname: Noël
authors.forename: Benjamin
authors.initials: B
authors.lastname: Nottelet
authors.forename: Jean
authors.initials: J
authors.lastname: Coudane
mesh_terms: D000818:Animals; D020811:Biomedical Technology / Q000379:methods*; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002850:Chromatography, Gel; D005029:Ethylenediamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D055595:Mechanical Phenomena / Q000187:drug effects; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008856:Microscopy, Fluorescence; D008970:Molecular Weight; D020442:Poloxamer / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D005029:Ethylenediamines; D011091:Polyesters; D011108:Polymers; C112299:Tetronic 1107; D014867:Water; D020442:Poloxamer; D019344:Lactic Acid; C033616:poly(lactide)
keywords: Cytocompatibility; Degradation properties; Mesenchymal stem cells; Poloxamer; Poloxamine; Poly(lactide)