title: Diastolic dysfunction of the left ventricle is associated with pulmonary edema after renal transplantation.
abstract: BACKGROUND
  Post-operative pulmonary complications are associated with high mortality and graft loss in renal transplantation recipients. Left ventricular diastolic dysfunction is not uncommon in patients with chronic renal failure, including those with preserved left ventricular systolic function. The purpose of this study was to determine the relationship between left ventricular diastolic dysfunction and incidence of post-operative pulmonary edema in renal transplantation recipients with preserved left ventricular systolic function.
  
  
  METHODS
  Pre-operative left ventricular function and incidence of pulmonary edema were retrospectively studied in 209 patients who underwent living-donor renal transplantation between January 2010 and October 2012. Left ventricular systolic and diastolic functions were evaluated by ejection fraction and E/E' ratio, retrospectively, using transthoracic echocardiography. Pulmonary edema was defined by evidence of pulmonary congestion on the chest X-ray together with PaO2 /FiO2 ratio < 300 mmHg.
  
  
  RESULTS
  Eleven out of 190 (5.8%) renal transplantation patients with preserved left ventricular systolic function developed post-operative pulmonary edema. Patients with pulmonary edema had a significantly higher geometric mean (95% confidence interval) of E/E' ratio than those without pulmonary edema [17.8 (14.1-22.5) vs. 11.1 (10.6-11.7), P = 0.001].
  
  
  CONCLUSIONS
  Pre-operative left ventricular diastolic dysfunction correlated with the development of post-operative pulmonary edema in renal transplantation recipients. Meticulous intraoperative volume therapy is important to avoid post-operative pulmonary edema in such patients.
authors.affiliation: Operating Rooms, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Higashi
authors.forename: K
authors.initials: K
authors.lastname: Yamaura
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Shimauchi
authors.forename: H
authors.initials: H
authors.lastname: Saiki
authors.forename: S
authors.initials: S
authors.lastname: Hoka
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D004452:Echocardiography; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000503:physiopathology; D011654:Pulmonary Edema / Q000150:complications / Q000503:physiopathology*; D012189:Retrospective Studies; D013318:Stroke Volume / Q000502:physiology; D017211:Treatment Failure; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology*