title: An epigenetic trap involved in olfactory receptor gene choice.
abstract: Reporting recently in Cell, Lyons et al. (2013) reveal key roles for transient LSD1 histone demethylase activity in activation of a single olfactory receptor allele and suppression of the rest of the olfactory receptor gene family, thereby locking in the expression of a single olfactory receptor per sensory neuron.
authors.affiliation: Fishberg Department of Neuroscience and Friedman Brain Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Calder
authors.initials: C
authors.lastname: Reinsborough
authors.forename: Andrew
authors.initials: A
authors.lastname: Chess
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D018035:Receptors, Odorant / Q000235:genetics*; D011984:Sensory Receptor Cells / Q000378:metabolism*
chemical_list: D018035:Receptors, Odorant; D010089:Oxidoreductases, N-Demethylating; D000262:Adenylyl Cyclases