title: Obstetric outcomes of patients undergoing total laparoscopic radical trachelectomy for early stage cervical cancer.
abstract: OBJECTIVE
  To assess the obstetric outcomes of our total laparoscopic radical trachelectomy (TLRT) cases for early stage cervical cancer.
  
  
  METHODS
  A total of 56 patients who underwent TLRT between December 2001 and August 2012 were reviewed retrospectively using clinicopathological, surgical, and follow-up data from patients' medical records.
  
  
  RESULTS
  We performed this operation on 56 patients during the study period. The mean age of these 56 patients was 31.9 years (range 22-42 years). Fifty-three patients' fertility was preserved without requiring post-operative adjuvant treatment. Twenty-five women attempted to conceive, of whom 13 succeeded for a total of 21 pregnancies (52% pregnancy rate). Ten of these 21 pregnancies were the result of assisted reproductive technologies. Of those, 5 resulted in first trimester miscarriages, 2 in second trimester miscarriages, and 13 in live births. Ten pregnancies reached the third trimester. Preterm premature rupture of membranes (8/13, 61.5%) was the most common complication during pregnancy. The rate of preterm delivery was 47.6%. Three patients delivered at 22-28 weeks of gestational age. Two of these babies showed permanent damage: one has cerebral palsy; the other has developmental retardation. One pregnancy is ongoing.
  
  
  CONCLUSIONS
  TLRT is a useful technique associated with an excellent pregnancy rate in fertility-preserving surgery to treat early stage cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Kurashiki Medical Center, Japan. Electronic address: eastfield@mac.com.
authors.forename: Keiko
authors.initials: K
authors.lastname: Ebisawa
authors.forename: Mizuki
authors.initials: M
authors.lastname: Takano
authors.forename: Mika
authors.initials: M
authors.lastname: Fukuda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Tomonori
authors.initials: T
authors.lastname: Hada
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ota
authors.forename: Shozo
authors.initials: S
authors.lastname: Kurotsuchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kanao
authors.forename: Masaaki
authors.initials: M
authors.lastname: Andou
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000230:Adenocarcinoma / Q000188:drug therapy / Q000601:surgery*; D000328:Adult; D018196:Carcinoma, Adenosquamous / Q000188:drug therapy / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000601:surgery*; D002821:Chorioamnionitis / Q000209:etiology; D005260:Female; D059247:Fertility Preservation; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D010535:Laparoscopy; D050498:Live Birth; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000601:surgery*; D055815:Young Adult
keywords: Cervical cancer; Total laparoscopic radical trachelectomy