title: EADB: an estrogenic activity database for assessing potential endocrine activity.
abstract: Endocrine-active chemicals can potentially have adverse effects on both humans and wildlife. They can interfere with the body's endocrine system through direct or indirect interactions with many protein targets. Estrogen receptors (ERs) are one of the major targets, and many endocrine disruptors are estrogenic and affect the normal estrogen signaling pathways. However, ERs can also serve as therapeutic targets for various medical conditions, such as menopausal symptoms, osteoporosis, and ER-positive breast cancer. Because of the decades-long interest in the safety and therapeutic utility of estrogenic chemicals, a large number of chemicals have been assayed for estrogenic activity, but these data exist in various sources and different formats that restrict the ability of regulatory and industry scientists to utilize them fully for assessing risk-benefit. To address this issue, we have developed an Estrogenic Activity Database (EADB; http://www.fda.gov/ScienceResearch/BioinformaticsTools/EstrogenicActivityDatabaseEADB/default.htm) and made it freely available to the public. EADB contains 18,114 estrogenic activity data points collected for 8212 chemicals tested in 1284 binding, reporter gene, cell proliferation, and in vivo assays in 11 different species. The chemicals cover a broad chemical structure space and the data span a wide range of activities. A set of tools allow users to access EADB and evaluate potential endocrine activity of chemicals. As a case study, a classification model was developed using EADB for predicting ER binding of chemicals.
authors.affiliation: * Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079;
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Fang
authors.forename: Ann M
authors.initials: AM
authors.lastname: Richard
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Bray
authors.forename: Richard S
authors.initials: RS
authors.lastname: Judson
authors.forename: Guangxu
authors.initials: G
authors.lastname: Zhou
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Colatsky
authors.forename: Jason L
authors.initials: JL
authors.lastname: Aungst
authors.forename: Christina
authors.initials: C
authors.lastname: Teng
authors.forename: Steve C
authors.initials: SC
authors.lastname: Harris
authors.forename: Weigong
authors.initials: W
authors.lastname: Ge
authors.forename: Susie Y
authors.initials: SY
authors.lastname: Dai
authors.forename: Zhenqiang
authors.initials: Z
authors.lastname: Su
authors.forename: Abigail C
authors.initials: AC
authors.lastname: Jacobs
authors.forename: Wafa
authors.initials: W
authors.lastname: Harrouk
authors.forename: Roger
authors.initials: R
authors.lastname: Perkins
authors.forename: Weida
authors.initials: W
authors.lastname: Tong
authors.forename: Huixiao
authors.initials: H
authors.lastname: Hong
mesh_terms: D000818:Animals; D062126:Databases, Chemical; D052244:Endocrine Disruptors / Q000633:toxicity*; D004702:Endocrine Glands / Q000187:drug effects*; D004967:Estrogens / Q000494:pharmacology*; D006801:Humans
chemical_list: D052244:Endocrine Disruptors; D004967:Estrogens
keywords: database.; endocrine disruptor; estrogen receptor; estrogenic activity