title: HLA in a cohort of Brazilian patients with sarcoidosis.
abstract: Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. Hereditary etiology has been proposed as a cause of the sarcoidosis, and some Human Leucocyte Antigen (HLA) alleles have been related to the diagnosis or severity of the disease. Löfgren's syndrome has been linked to patients with the DRB1*03 allele, and non-resolving disease has been associated with the DRB1*07, DRB1*14 and DRB1*15 alleles. However, the results observed in Caucasian patients are not reproducible in other populations, such as in Japanese individuals. The aim of this study is to examine the HLA alleles in Brazilian patients with sarcoidosis confirmed by biopsy. Sixty-three patients were included in the study, and the HLA alleles were compared with 126 control individuals. HLA-A, -B, -C, -DRB1 and -DQB1 genes were typed using a Luminex Multi-analyte profiling system (One Lambda, Inc. Canoga Park, CA). Among sarcoidosis patients, the HLA A*23, A*80, B*08, B*41, DQB1*05 and DRB1*14 antigens tended to be more common than in the controls, whereas the B*44, B*45, B*51, B*58, DRB1*15 and DRB1*16 alleles were more frequently found in control subjects than in the sarcoidosis patients. However, after Bonferroni correction, only the HLA-DRB1*14 allele was found to be significantly different between sarcoidosis patients and controls (pC=0.0047, OR=11.69, CI=2.47-55.22). This allele was more frequent in mestizos and black patients. The presence of an HLA-DRB1*14 allele might determine the risk of sarcoidosis in Brazilian individuals, especially in mestizos and black patients.
authors.affiliation: Department of Pulmonary Medicine, Faculdade de Ciências Médicas, Rio de Janeiro State University, Brazil. Electronic address: ccosta.uerj@gmail.com.
authors.forename: Cláudia Henrique
authors.initials: CH
authors.lastname: da Costa
authors.forename: Vinicius Lemos
authors.initials: VL
authors.lastname: Silva
authors.forename: Gustavo Milson
authors.initials: GM
authors.lastname: Fabricio-Silva
authors.forename: Magaly
authors.initials: M
authors.lastname: Usnayo
authors.forename: Rogério
authors.initials: R
authors.lastname: Rufino
authors.forename: Luís Cristóvão
authors.initials: LC
authors.lastname: Porto
mesh_terms: D000328:Adult; D000483:Alleles; D001938:Brazil; D015331:Cohort Studies; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology
chemical_list: D006680:HLA Antigens