title: The interaction between gut microbiota and age-related changes in immune function and inflammation.
abstract: Intestinal microbiota and gut immune systems interact each other, maintaining a condition of homeostasis in the context of the intestinal habitat. However, both systems undergo modifications in elderly, thus accounting for a low grade inflammatory status which, in turn, may evolve toward more severe pathological conditions such as inflammatory bowel disease and colon rectal cancer. In addition, in western societies dietary habits may negatively influence the microbiota composition, also altering gut immune response which is per se impaired in elderly. In order to prevent the outcome of aged-related disease, supplementation of nutraceuticals able to correct abnormalities of both immune system and microbiota has become more frequent than in the past. In this respect, a better identification of components of the aged microbiota as well as a deeper analysis of gut mucosal immunity function should be pursued.
authors.affiliation: Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, Policlinico, Piazza G, Cesare 11, 70124, Bari, Italy. thea.magrone@libero.it.
authors.forename: Thea
authors.initials: T
authors.lastname: Magrone
authors.forename: Emilio
authors.initials: E
authors.lastname: Jirillo
references.citation: PLoS One. 2010 May 17;5(5):e10667
references.pmid: 20498852
references.citation: Nutr Rev. 2011 Jul;69(7):392-403
references.pmid: 21729093
references.citation: Appl Microbiol. 1974 May;27(5):961-79
references.pmid: 4598229
references.citation: Adv Immunol. 2010;108:111-65
references.pmid: 21056730
references.citation: Nature. 2006 Dec 21;444(7122):1022-3
references.pmid: 17183309
references.citation: Curr Pharm Des. 2010;16(6):584-96
references.pmid: 20388068
references.citation: J Agric Food Chem. 2011 Dec 28;59(24):12815-20
references.pmid: 22060186
references.citation: Curr Top Med Chem. 2011;11(14):1767-79
references.pmid: 21506932
references.citation: Curr Opin Gastroenterol. 2007 Nov;23(6):673-8
references.pmid: 17906446
references.citation: Mucosal Immunol. 2012 May;5(3):240-7
references.pmid: 22354322
references.citation: Am J Clin Nutr. 2001 Dec;74(6):833-9
references.pmid: 11722966
references.citation: Am J Clin Nutr. 2012 Jun;95(6):1323-34
references.pmid: 22552027
references.citation: Curr Pharm Des. 2010;16(7):854-8
references.pmid: 20388097
references.citation: Appl Environ Microbiol. 2000 Oct;66(10):4523-7
references.pmid: 11010909
references.citation: Trends Immunol. 2009 Jul;30(7):334-43
references.pmid: 19540811
references.citation: Immunity. 2011 Feb 25;34(2):237-46
references.pmid: 21333554
references.citation: Poult Sci. 2011 Nov;90(11):2663-9
references.pmid: 22010256
references.citation: Endocr Metab Immune Disord Drug Targets. 2012 Dec;12(4):361-7
references.pmid: 23017185
references.citation: Int J Food Microbiol. 2011 Sep 1;149(1):73-80
references.pmid: 21450362
references.citation: Ageing Res Rev. 2010 Apr;9(2):107-16
references.pmid: 19874918
references.citation: Immunology. 2009 Sep;128(1 Suppl):e805-15
references.pmid: 19740342
references.citation: Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):563-4
references.pmid: 22945446
references.citation: Pharmacol Res. 2013 Mar;69(1):11-20
references.pmid: 23079287
references.citation: Nature. 2012 Jul 5;487(7405):104-8
references.pmid: 22722865
references.citation: Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):599-608
references.pmid: 22907164
references.citation: Curr Pharm Des. 2012;18(1):34-42
references.pmid: 22211682
references.citation: Curr Opin Pharmacol. 2009 Aug;9(4):405-10
references.pmid: 19589728
references.citation: Clin Infect Dis. 2005 Jan 1;40(1):28-37
references.pmid: 15614689
references.citation: Digestion. 2011;84(2):89-101
references.pmid: 21494040
references.citation: Clin Exp Immunol. 2012 Mar;167(3):405-12
references.pmid: 22288583
references.citation: Annu Rev Immunol. 2007;25:381-418
references.pmid: 17378762
references.citation: J Exp Med. 2010 Jun 7;207(6):1321-32
references.pmid: 20498021
references.citation: Br J Nutr. 2010 Aug;104 Suppl 2:S1-63
references.pmid: 20920376
references.citation: Trends Immunol. 2012 Jan;33(1):42-8
references.pmid: 22079120
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2159-64
references.pmid: 20080669
references.citation: Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):561-2
references.pmid: 22890110
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9
references.pmid: 20566854
references.citation: Appl Environ Microbiol. 2002 Jul;68(7):3401-7
references.pmid: 12089021
references.citation: Annu Rev Cell Dev Biol. 2000;16:301-32
references.pmid: 11031239
references.citation: Trends Immunol. 2009 Jul;30(7):293-4
references.pmid: 19541534
references.citation: Mutat Res. 2010 Aug 7;690(1-2):50-6
references.pmid: 19666034
references.citation: Curr Pharm Des. 2013;19(7):1329-42
references.pmid: 23151182
references.citation: J Appl Microbiol. 2007 May;102(5):1197-208
references.pmid: 17448155
references.citation: Physiology (Bethesda). 2008 Apr;23:64-74
references.pmid: 18400689
references.citation: Cell Host Microbe. 2008 Jun 12;3(6):344-7
references.pmid: 18541210
references.citation: J Nutr. 2003 Mar;133(3):801-7
references.pmid: 12612156
references.citation: Cell. 2006 Feb 24;124(4):837-48
references.pmid: 16497592
references.citation: Int J Food Microbiol. 2010 Apr 15;138(3):223-31
references.pmid: 20193971
references.citation: Br J Nutr. 2013 May 28;109(10):1856-65
references.pmid: 22947249
references.citation: Science. 2005 Jun 10;308(5728):1635-8
references.pmid: 15831718
references.citation: Gut. 2001 Feb;48(2):198-205
references.pmid: 11156640
references.citation: Cell. 2009 Oct 30;139(3):485-98
references.pmid: 19836068
references.citation: NMR Biomed. 2008 Jul;21(6):615-26
references.pmid: 18085514
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4586-91
references.pmid: 20571116
references.citation: Ageing Res Rev. 2012 Apr;11(2):297-319
references.pmid: 22322094
references.citation: IDrugs. 2003 Jun;6(6):573-80
references.pmid: 12811680