title: A new phenoxazine derivative isolated from marine sediment actinomycetes, Nocardiopsis sp. 236.
abstract: During screening of marine actinomycetes for anti-mycobacterial activity, a new phenoxazine derivative (1) was isolated, along with 6-phenazinediol (2), 6-methoxy-1-phenazinol (3), nocardamin (4), and 3-pyridinecarboxylic acid (5), from a culture of Nocardiopsis sp. 236 collected from the west Pacific. The chemical structure of 1 was established on the basis of 1D-, 2D-NMR, and HRQ-TOF MS data. All compounds were evaluated for their anti-mycobacterial activity in vitro, and only compounds 2 and 3 exhibited weak activity.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China.
authors.forename: C H
authors.initials: CH
authors.lastname: Lu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Li
authors.forename: H X
authors.initials: HX
authors.lastname: Wang
authors.forename: B M
authors.initials: BM
authors.lastname: Wang
authors.forename: Y M
authors.initials: YM
authors.lastname: Shen
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D019015:Geologic Sediments / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009615:Nocardia / Q000737:chemistry / Q000378:metabolism*; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010078:Oxazines; C039203:phenoxazine