title: The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth.
abstract: L1 plays a role in neural development. However, it remains unclear how L1 plays this role. In the present study, we have shown extensive outgrowth of long neurites in cerebellar neurons after treatment with either L1 or L1 antibody. Notably, the mRNA level of FGF21 was significantly increased in both L1 and L1 antibody treated neurons compared to control group. Consistently, the neurite outgrowth promoted by L1 was strongly inhibited by siRNA against FGF21 gene or a treatment of cells with FGFR inhibitor. These results demonstrate that FGF21/FGFR signaling promotes the neurite outgrowth in a L1-dependent manner.
authors.affiliation: Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116044, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Huang
authors.forename: Jiliang
authors.initials: J
authors.lastname: Hu
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Zara
authors.initials: Z
authors.lastname: Zhuyun Yang
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Keli
authors.initials: K
authors.lastname: Ma
authors.forename: Melitta
authors.initials: M
authors.lastname: Schachner
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Xiao
authors.forename: Yali
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D051379:Mice; D039842:Neural Cell Adhesion Molecule L1 / Q000378:metabolism*; D016501:Neurites / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D039842:Neural Cell Adhesion Molecule L1; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors
keywords: FGF21; FGFR; L1; Neurite outgrowth