title: Spontaneous Rhabdomyosarcoma in a Common Marmoset ( Callithrix jacchus ).
abstract: The common marmoset (Callithrix jacchus) is now widely used in various research fields, including toxicology. However, information about the background pathology of this species is scarce. Here, we report a case of rhabdomyosarcoma that spontaneously occurred in a common marmoset. A 44-month-old male common marmoset was euthanized due to bilateral hind limb paralysis. At necropsy, a 2×2×5-cm intramuscular mass was observed in the lower right back. Histologically, the mass was mainly composed of interlacing bundles of spindle-shaped tumor cells. Immunohistochemically, the tumor cells were positive for myogenin, desmin, vimentin and alpha-smooth muscle actin. Ultrastructurally, the tumor cells contained bundles of myofilaments with Z-band-like structures. Thus, the tumor was diagnosed as a rhabdomyosarcoma. To our knowledge, this is the first report of spontaneous rhabdomyosarcoma that was definitely diagnosed in the common marmoset.
authors.affiliation: Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Tochitani
authors.forename: Izumi
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Kohei
authors.initials: K
authors.lastname: Hoshino
authors.forename: Kaoru
authors.initials: K
authors.lastname: Toyosawa
authors.forename: Mami
authors.initials: M
authors.lastname: Kouchi
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Koujitani
authors.forename: Juki
authors.initials: J
authors.lastname: Kimura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Funabashi
keywords: Callithrix jacchus; immunohistochemistry; pathology; rhabdomyosarcoma
references.citation: Lab Anim Sci. 1990 Mar;40(2):210-2
references.pmid: 2157108
references.citation: ORL J Otorhinolaryngol Relat Spec. 1999 Jan-Feb;61(1):52-4
references.pmid: 9892872
references.citation: Arch Pathol Lab Med. 2006 Dec;130(12):1878-81
references.pmid: 17149968
references.citation: Am J Surg Pathol. 2001 Sep;25(9):1150-7
references.pmid: 11688574
references.citation: Vet Pathol. 2008 Jan;45(1):80-4
references.pmid: 18192583
references.citation: Vet Pathol. 2010 Sep;47(5):969-76
references.pmid: 20460447
references.citation: J Med Primatol. 1998 Dec;27(6):319-24
references.pmid: 10203013
references.citation: Exp Toxicol Pathol. 2006 Jul;57(5-6):405-10
references.pmid: 16616834
references.citation: BMC Cancer. 2011 Feb 17;11:76
references.pmid: 21329505
references.citation: Cancer. 1995 Sep 15;76(6):1073-85
references.pmid: 8625211
references.citation: J Med Primatol. 2009 Oct;38(5):347-59
references.pmid: 19522731
references.citation: J Med Primatol. 1996 Dec;25(6):424-34
references.pmid: 9210028
references.citation: Vet Pathol. 1985 Jan;22(1):86-8
references.pmid: 3919492
references.citation: Cancer Res. 1969 Dec;29(12):2237-48
references.pmid: 4313005
references.citation: Pediatr Dev Pathol. 2005 Jul-Aug;8(4):427-34
references.pmid: 16220232
references.citation: Virchows Arch. 2010 Feb;456(2):167-79
references.pmid: 19688222
references.citation: Toxicol Pathol. 2003 Jan-Feb;31 Suppl:123-7
references.pmid: 12597440