title: No acute suppression of cerebrospinal fluid corticotropin-releasing hormone in man by cortisol administration.
abstract: Corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) is regarded as index of brain endocrine and behavioral functioning. We investigated the acute effects of intravenous cortisol (100mg) vs. placebo on serial CSF CRH in ten healthy men. CSF CRH concentrations were not significantly suppressed by cortisol within 3h. The origin and regulation of CSF CRH need further research.
authors.affiliation: University Hospital Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany. Electronic address: kellner@uke.uni-hamburg.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Kellner
authors.forename: Cornelie
authors.initials: C
authors.lastname: Salzwedel
authors.forename: Viola
authors.initials: V
authors.lastname: Wortmann
authors.forename: Tatiana
authors.initials: T
authors.lastname: Urbanowicz
authors.forename: Kai
authors.initials: K
authors.lastname: Boelmans
authors.forename: Alexander
authors.initials: A
authors.lastname: Yassouridis
authors.forename: Günter K
authors.initials: GK
authors.lastname: Stalla
authors.forename: Klaus
authors.initials: K
authors.lastname: Wiedemann
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D001519:Behavior / Q000502:physiology; D001921:Brain / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid*; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D008297:Male
chemical_list: D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone
keywords: Cerebrospinal fluid (CSF); Corticotropin-releasing hormone (CRH); Cortisol