title: 18F-FDG PET and PET/CT in the Localization and Characterization of Lesions in Patients with Ovarian Cancer.
abstract: OBJECTIVE
  The aim was to compare the imaging findings of (18)F-fluorodeoxyglucose ((18)F-FDG) PET and integrated PET/CT in patients with primary, recurrent or metastatic ovarian cancer.
  
  
  METHODS
  21 women with ovarian cancer were evaluated. All patients had a integrated PET/CT scan. Localization, infiltration and uptake intensity of [(18)F]FDG were evaluated on PET and PET/CT. The certainty of localisation and characterisation was scored on a 3 point scale (L1 definite localisation; L2 probable localisation; L3 uncertain localisation; C1 benign; C2 equivocal; C3 malignant).
  
  
  RESULTS
  PET scored as L1 54 lesions (44%), as L2 51 (42%), and as L3 17 (14%). On the other hand, PET/CT scored as L1 120 lesions (98%), as L2 2 (2%), and none as L3. Thus PET/CT allowed a better localization in 54% of lesions. Moreover, PET scored as C1 25 lesions (20%), as C2 62 (51%), and as C3 35 (29%). On the other hand, PET/CT scored as C1 57 lesions (47%), as C2 13 (11%), and as C3 52 (42%). Thus PET/CT allowed a sensible reduction in the number of equivocal lesions (40%). Even when patients were subgrouped on the basis of clinical stage of the disease, PET/CT was capable of better definition of the lesions either for localization and for characterization.
  
  
  CONCLUSIONS
  In patients with ovarian cancer, PET/CT allows better anatomical localisation of pathologic uptake providing high accuracy for staging and restaging of ovarian cancer when compared with PET alone.
authors.affiliation: Azienda Ospedaliera Universitaria Federico II, Napoli, Italia.
authors.forename: M G
authors.initials: MG
authors.lastname: Caprio
authors.forename: D
authors.initials: D
authors.lastname: Capacchione
authors.forename: C
authors.initials: C
authors.lastname: Mainolfi
authors.forename: A M
authors.initials: AM
authors.lastname: Spera
authors.forename: B
authors.initials: B
authors.lastname: Salvatore
authors.forename: L
authors.initials: L
authors.lastname: Cella
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
authors.forename: L
authors.initials: L
authors.lastname: Pace
keywords: 18F-FDG; Ovarian Cancer; PET/CT
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