title: Protein sumoylation in brain development, neuronal morphology and spinogenesis.
abstract: Small ubiquitin-like modifiers (SUMOs) are polypeptides resembling ubiquitin that are covalently attached to specific lysine residue of target proteins through a specific enzymatic pathway. Sumoylation is now seen as a key posttranslational modification involved in many biological processes, but little is known about how this highly dynamic protein modification is regulated in the brain. Disruption of the sumoylation enzymatic pathway during the embryonic development leads to lethality revealing a pivotal role for this protein modification during development. The main aim of this review is to briefly describe the SUMO pathway and give an overview of the sumoylation regulations occurring in brain development, neuronal morphology and synapse formation.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, Laboratory of Excellence 'Network for Innovation on Signal Transduction Pathways in Life Sciences', UMR7275, Centre National de la Recherche Scientifique, University of Nice-Sophia-Antipolis, 660 route des lucioles, 06560, Valbonne, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Gwizdek
authors.forename: Frédéric
authors.initials: F
authors.lastname: Cassé
authors.forename: Stéphane
authors.initials: S
authors.lastname: Martin
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000502:physiology; D001921:Brain / Q000196:embryology*; D047108:Embryonic Development; D005057:Eukaryotic Cells / Q000378:metabolism; D005136:Eye Proteins / Q000502:physiology; D051528:Guanylate Kinases / Q000502:physiology; D006801:Humans; D064326:MEF2 Transcription Factors / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D051761:Paired Box Transcription Factors / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology; D025841:Small Ubiquitin-Related Modifier Proteins / Q000502:physiology*; D013116:Spinal Cord / Q000196:embryology*; D058207:Sumoylation / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D005136:Eye Proteins; D064326:MEF2 Transcription Factors; D009419:Nerve Tissue Proteins; D051761:Paired Box Transcription Factors; D018094:Receptors, Metabotropic Glutamate; D025841:Small Ubiquitin-Related Modifier Proteins; C111435:metabotropic glutamate receptor 8; D043743:Ubiquitin-Protein Ligase Complexes; C106868:CASK kinases; D051528:Guanylate Kinases
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