title: Genetic polymorphisms in XRCC1 gene and susceptibility to glioma in Chinese Han population.
abstract: Glioma is the most common type of primary brain malignancy in adults. The X-ray repair cross-complementing group 1 (XRCC1) is an important candidate gene for influencing the pathogenesis of glioma. This study aimed to evaluate the potential association between XRCC1 genetic polymorphisms and glioma susceptibility. This case-control study was conducted in Chinese Han populations consisting of 620 glioma cases and 630 cancer-free controls. XRCC1 genetic polymorphisms were detected by the polymerase chain reaction-restriction fragment length polymorphism and verified using DNA sequencing methods. The c.910A>G and c.1779C>G genetic polymorphisms were identified in this study. Our data suggested that the genotypes/alleles of these two genetic polymorphisms were statistically associated with the increased risk of glioma. As for c.910A>G, the risk of glioma for genotype GG was significantly higher than wild genotype AA (odds ratio (OR) = 1.98, 95% confidence interval (CI) 1.33-2.94, P = 0.001). As for c.1779C>G, the genotype GG was statistically associated with the increased risk of glioma compared to wild genotype CC (OR = 1.80, 95% CI 1.17-2.78, P = 0.007). Both of alleles G in c.910A>G and c.1779C>G may contribute to glioma susceptibility (G versus (vs.) A, OR = 1.30, 95% CI 1.09-1.54, P = 0.003; G vs. C, OR = 1.19, 95% CI 1.00-1.42, P = 0.045). Our findings indicate that the c.910A>G and c.1779C>G genetic polymorphisms are associated with the susceptibility to glioma in Chinese Han populations and might be used as molecular markers for evaluating glioma risk.
authors.affiliation: Department of Neurosurgery, The First Bethune Hospital, Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin Province, People's Republic of China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jin
authors.forename: Haiyang
authors.initials: H
authors.lastname: Xu
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human
references.citation: Br J Neurosurg. 2010 Oct;24(5):561-5
references.pmid: 20868244
references.citation: Gene. 2012 Nov 10;509(2):223-7
references.pmid: 22951806
references.citation: Asian Pac J Cancer Prev. 2013;14(1):449-52
references.pmid: 23534771
references.citation: Neuroepidemiology. 2007;29(1-2):55-8
references.pmid: 17898525
references.citation: Curr Opin Oncol. 2011 Nov;23(6):643-7
references.pmid: 21825990
references.citation: Neuro Oncol. 2010 Jan;12(1):37-48
references.pmid: 20150366
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):204-14
references.pmid: 19124499
references.citation: BMC Med Genet. 2012 Oct 26;13:97
references.pmid: 23101479
references.citation: PLoS One. 2013;8(1):e55597
references.pmid: 23383237
references.citation: Cancer Res. 2004 Aug 15;64(16):5560-3
references.pmid: 15313891
references.citation: Asian Pac J Cancer Prev. 2011;12(10):2547-50
references.pmid: 22320953
references.citation: Mol Biol Rep. 2013 Jan;40(1):567-72
references.pmid: 23096083
references.citation: Acta Neuropathol. 2005 Jan;109(1):93-108
references.pmid: 15685439
references.citation: Lancet. 2012 May 26;379(9830):1984-96
references.pmid: 22510398
references.citation: Asian Pac J Cancer Prev. 2011;12(11):2981-4
references.pmid: 22393975
references.citation: Mol Biol Rep. 2012 Sep;39(9):8695-9
references.pmid: 22699883
references.citation: J Neurooncol. 2008 Jun;88(2):135-42
references.pmid: 18330515
references.citation: Mol Aspects Med. 2007 Jun-Aug;28(3-4):258-75
references.pmid: 17628657
references.citation: Exp Ther Med. 2012 Dec;4(6):1057-1062
references.pmid: 23226774
references.citation: Nat Clin Pract Neurol. 2006 Sep;2(9):494-503; quiz 1 p following 516
references.pmid: 16932614
references.citation: Asian Pac J Cancer Prev. 2012;13(9):4783-8
references.pmid: 23167420
references.citation: N Engl J Med. 2008 Jul 31;359(5):492-507
references.pmid: 18669428
references.citation: Int J Mol Sci. 2013 Feb 05;14(2):3314-24
references.pmid: 23385236
references.citation: Asian Pac J Cancer Prev. 2012;13(10):4905-8
references.pmid: 23244079
references.citation: DNA Repair (Amst). 2011 Dec 10;10(12):1282-93
references.pmid: 22041025