title: Rh(III)-catalyzed synthesis of multisubstituted isoquinoline and pyridine N-oxides from oximes and diazo compounds.
abstract: Multisubstituted isoquinoline and pyridine N-oxides have been prepared by Rh(III)-catalyzed cyclization of oximes and diazo compounds via aryl and vinylic C-H activation. This intermolecular annulation involving tandem C-H activation, cyclization, and condensation steps proceeds under mild conditions, obviates the need for oxidants, releases N2 and H2O as the byproducts, and displays a broad substituent scope.
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Zhuangzhi
authors.initials: Z
authors.lastname: Shi
authors.forename: Dennis C
authors.initials: DC
authors.lastname: Koester
authors.forename: Mélissa
authors.initials: M
authors.lastname: Boultadakis-Arapinis
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D007546:Isoquinolines / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D001391:Azo Compounds; D007546:Isoquinolines; D010091:Oximes; D011725:Pyridines; C013229:pyridine N-oxide; D012238:Rhodium