title: Atom economical, one-pot, three-reaction cascade to novel tricyclic 2,4-dihydro-1H-benzo[f]isochromenes.
abstract: Reaction of 6-methyl-1-phenylhept-3-yne-2,6-diol with various aldehydes under Lewis acid conditions provides an atom economical, two-component cascade reaction sequence to novel 2,4-dihydro-1H-benzo[f]isochromene compounds. Aliphatic aldehydes as well as electron-deficient and -rich aromatic aldehydes can be used.
authors.affiliation: Department of Chemistry, The College of William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187-8795, USA. rjhink@wm.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hinkle
authors.forename: Shane E
authors.initials: SE
authors.lastname: Lewis
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000929:Antidepressive Agents, Tricyclic / Q000138:chemical synthesis* / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: C585705:2,4-dihydro-1H-benzo(f)isochromene; D000447:Aldehydes; D000929:Antidepressive Agents, Tricyclic; D001578:Benzopyrans; D058116:Lewis Acids
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