title: Applying pharmacokinetics to veterinary clinical practice.
abstract: This article describes clinical examples in which pharmacokinetic parameters can be used to optimize veterinary patient care. Specific applications include extrapolating drug dosages, optimizing therapy with therapeutic drug monitoring, interpreting pharmacokinetic information provided by drug labels and pharmaceutical companies, and adjusting drug dosages in patients with hepatic or renal failure.
authors.affiliation: School of Veterinary Medicine, Department of Medical Sciences, University of Wisconsin-Madison, Madison, WI 53706-1102, USA. latrepanier@svm.vetmed.wisc.edu
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Trepanier
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006801:Humans; D008826:Microbial Sensitivity Tests; D056687:Off-Label Use; D019155:Veterinary Drugs / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D014730:Veterinary Medicine / Q000592:standards*
chemical_list: D019155:Veterinary Drugs
keywords: Bioavailability; Drug biotransformation; Drug dose adjustment; Therapeutic drug monitoring