title: Cytotoxic flavanes from Uraria clarkei.
abstract: Two new flavanes, (2R)-4'-hydroxy-2',5,7-trimethoxyflavane (1) and (2R,4R)-2',4'-dihydroxy-5,7-dimethoxyflavan-4-ol (2), were isolated from Uraria clarkei, together with two known compounds 5,7-dimethoxy-4'-hydroxyflavan (3) and 5,7,4'-trimethoxyflavan (4). The structures of the new flavanes were characterized by analyses of the MS, IR, UV, CD, 1D, and 2D NMR data. Cytotoxicity test suggested that compounds 1-4 possessed slight activity against K-562 and Hela cell lines, with the IC50 values ranging from 26.6 to 56.3 μM.
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities , Kunming , 650500 , China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Jiang
authors.forename: Xi-Shan
authors.initials: XS
authors.lastname: Bai
authors.forename: Hui
authors.initials: H
authors.lastname: Liang
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Li
authors.forename: Jun-Ming
authors.initials: JM
authors.lastname: Guo
authors.forename: Xiang-Zhong
authors.initials: XZ
authors.lastname: Huang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C585797:(2R)-4'-hydroxy-2',5,7-trimethoxyflavane; C585798:(2R,4R)-2',4'-dihydroxy-5,7-dimethoxyflavan-4-ol; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids