title: A fluorescent guanosine dinucleoside as a selective switch-on sensor for c-myc G-quadruplex DNA with potent anticancer activities.
abstract: Like likes like! A novel fluorescent C2 -symmetric guanosine-based dinucleoside has been engineered by chemical ligation of two guanosine units with a biocompatible dansyl tag. The nucleoside exhibits high selectivity for c-myc G-quadruplex DNA through fluorescence enhancement over duplex DNA and other promoter G-quadruplexes (see scheme). It stains the nucleus preferentially, arrests the cell cycle at the G2/M phase, inhibits cell growth, and induces apoptosis in A375 cancer cells.
authors.affiliation: Department of Organic Chemistry, Indian Association for the Cultivation of Science Jadavpur, Kolkata 700032, India.
authors.forename: Y Pavan
authors.initials: YP
authors.lastname: Kumar
authors.forename: Sudipta
authors.initials: S
authors.lastname: Bhowmik
authors.forename: Rabindra Nath
authors.initials: RN
authors.lastname: Das
authors.forename: Irene
authors.initials: I
authors.lastname: Bessi
authors.forename: Sushovan
authors.initials: S
authors.lastname: Paladhi
authors.forename: Rita
authors.initials: R
authors.lastname: Ghosh
authors.forename: Harald
authors.initials: H
authors.lastname: Schwalbe
authors.forename: Jyotirmayee
authors.initials: J
authors.lastname: Dash
mesh_terms: D004247:DNA / Q000235:genetics / Q000378:metabolism; D054856:G-Quadruplexes / Q000187:drug effects*; D006151:Guanosine / Q000235:genetics*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000737:chemistry* / Q000628:therapy; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D016271:Proto-Oncogene Proteins c-myc; D006151:Guanosine; D004247:DNA
keywords: G-quadruplex DNA; cell cycles; click chemistry; fluorescence; nucleosides