title: [The effect of hypertension and it's therapy on cognitive performance of asymptomatic hypertensive patients].
abstract: The essential hypertension increases the risk of cognitive impairment even in symptom-free patients. Sixty, non-treated hypertensives were investigated (44 +/- 10.5 év) with nine pszichological tests, measuring the reaction time, attention, short and long-term memory, psychomotor speed etc. The results of nine tests were summarized and compared with those of age-matched control persons (n = 98). All hypertensives had normal CT findings. The carotid intima-media-thickness, the arterial stiffness and the velocities in the middle cerebral arteries were also analyzed (with tilting table test). The sum of the results of cognitive tests was significantly worse than that of controls 14.8 +/- 7.1 vs. 27.8 +/- 5.5 p < 0.0001. The results of intima-media thickness and stiffness measurements were also significantly worse compared with controls while the middle cerebral velocities did not differ. After one year antihypertensive therapy not only the improvement of blood pressure, intima-media thickness and stiffness values could be detected but also the score of summarized cognitive tests improved (from 17.4 +/- 6.0 to 31.6 +/- 6.0 p < 0.0001).
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Neurológiai Klinika, Debrecen. neuro@dote.hu
authors.forename: László
authors.initials: L
authors.lastname: Csiba
authors.forename: Katalin Réka
authors.initials: KR
authors.lastname: Kovács
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001288:Attention; D001794:Blood Pressure / Q000187:drug effects; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D057567:Memory, Long-Term; D008570:Memory, Short-Term; D008875:Middle Aged; D011581:Psychological Tests; D011597:Psychomotor Performance; D011930:Reaction Time; D018667:Tilt-Table Test; D059289:Vascular Stiffness / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents