title: [Effect of antipsychotic amisulpride on immune reactivity].
abstract: The effect of atypical antipsychotic solian (amisulpride), binding predominantly to dopamine D2/D3-receptors, on the immune reactivity has been studied in mice of the CBA strain with different psychoemotional states (aggressive and submissive behavior). In addition, the effect of solian on the expression of various CD-markers of lymphocytes in has been analyzed in vitro for patients with schizophrenia diagnosis. Chronic (10 days) administration of solian in mice at a dose of 5.0 mg/kg resulted in a significant suppression of the immune response to T-dependent antigen (sheep red blood cells). This effect was manifested in animals with both psychoemotional states, but was more expressed in aggressive animals. In the in vitro system, solian produced opposite effects on the expression of surface CD receptors in lymphocytes of patients with schizophrenia. It is suggested that solian does not only affects immune function through D2 receptors of the brain, but also directly influences immunocompetent cells.
authors.forename: G V
authors.initials: GV
authors.lastname: Idova
authors.forename: E L
authors.initials: EL
authors.lastname: Al'perina
authors.forename: O A
authors.initials: OA
authors.lastname: Lobacheva
authors.forename: E N
authors.initials: EN
authors.lastname: Zhukova
authors.forename: M A
authors.initials: MA
authors.lastname: Cheĭdo
authors.forename: T A
authors.initials: TA
authors.lastname: Meniavtseva
authors.forename: T P
authors.initials: TP
authors.lastname: Vetlugina
mesh_terms: D000077582:Amisulpride; D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D050637:Receptors, Dopamine D3 / Q000819:agonists* / Q000276:immunology; D012559:Schizophrenia / Q000188:drug therapy / Q000276:immunology; D012756:Sheep; D013312:Stress, Physiological / Q000187:drug effects* / Q000276:immunology; D013469:Sulpiride / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D015703:Antigens, CD; D014150:Antipsychotic Agents; D050637:Receptors, Dopamine D3; D013469:Sulpiride; D000077582:Amisulpride