title: The invisible arm of immunity in common cancer chemoprevention agents.
abstract: Immunoprevention refers to a strategy of preventing pathogen-associated and spontaneous cancers through the use of vaccines, antibodies, and immune modulators. Immune modulators function by enhancing the endogenous ability of the immune system to monitor for malignancy, so-called "immunosurveillance." There is growing evidence that many of the most promising cancer chemoprevention agents including aspirin, COX-2 inhibitors, aromatase inhibitors, and bisphosphonates mediate their effects, in part, by enhancing immunosurveillance and reversing the immune evasive mechanisms that premalignant lesions use. In the following review, we introduce critical components of the human immune surveillance system-dendritic cells, T cells, and immune suppressive cells-and discuss the emerging data suggesting that common chemoprevention agents may modulate the function of these immunologic cells.
authors.affiliation: Tumor Vaccine Group, University of Washington, Box 358050, Seattle, WA 98109, USA. marzbani@u.washington.edu
authors.forename: Edmond
authors.initials: E
authors.lastname: Marzbani
authors.forename: Carol
authors.initials: C
authors.lastname: Inatsuka
authors.forename: Hailing
authors.initials: H
authors.lastname: Lu
authors.forename: Mary L
authors.initials: ML
authors.lastname: Disis
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents
references.citation: J Immunol. 2006 Jul 1;177(1):246-54
references.pmid: 16785520
references.citation: Nat Rev Cancer. 2012 Mar 15;12(4):298-306
references.pmid: 22419253
references.citation: Cancer Res. 2011 Jul 1;71(13):4562-72
references.pmid: 21646473
references.citation: Nat Rev Immunol. 2008 Jan;8(1):59-73
references.pmid: 18097448
references.citation: Gastroenterology. 2006 Oct;131(4):1086-95
references.pmid: 17030179
references.citation: Am J Med. 2012 Jun;125(6):560-7
references.pmid: 22513195
references.citation: Clin Cancer Res. 2010 Feb 1;16(3):784-9
references.pmid: 20103670
references.citation: Cancer Prev Res (Phila). 2011 Mar;4(3):354-64
references.pmid: 21372035
references.citation: Clin Cancer Res. 2008 Dec 15;14(24):8270-8
references.pmid: 19088044
references.citation: Lancet. 2011 Jan 1;377(9759):31-41
references.pmid: 21144578
references.citation: Cancer Prev Res (Phila). 2010 Nov;3(11):1451-61
references.pmid: 20947488
references.citation: Cancer Res. 2007 May 1;67(9):4507-13
references.pmid: 17483367
references.citation: J Natl Cancer Inst. 2009 Jan 21;101(2):107-13
references.pmid: 19141783
references.citation: J Exp Med. 2003 Jan 20;197(2):163-8
references.pmid: 12538656
references.citation: Gastroenterology. 1994 Oct;107(4):1183-8
references.pmid: 7926468
references.citation: Cell. 2011 Mar 4;144(5):646-74
references.pmid: 21376230
references.citation: Curr Opin Immunol. 2011 Apr;23(2):293-8
references.pmid: 21295956
references.citation: Science. 2006 Sep 29;313(5795):1960-4
references.pmid: 17008531
references.citation: Lancet. 2012 Apr 28;379(9826):1602-12
references.pmid: 22440946
references.citation: Cancer Immunol Immunother. 2009 Jun;58(6):941-53
references.pmid: 18979098
references.citation: Int Immunopharmacol. 2007 Feb;7(2):140-51
references.pmid: 17178380
references.citation: Cancer Prev Res (Phila). 2012 Feb;5(2):205-15
references.pmid: 22030090
references.citation: Anticancer Res. 2003 Jan-Feb;23(1A):363-98
references.pmid: 12680238
references.citation: Nat Immunol. 2003 Mar;4(3):201
references.pmid: 12605223
references.citation: Clin Exp Immunol. 2010 Aug;161(2):290-7
references.pmid: 20491785
references.citation: J Cell Mol Med. 2010 Dec;14(12):2803-15
references.pmid: 19818098
references.citation: Blood. 2000 Jul 15;96(2):384-92
references.pmid: 10887096
references.citation: Br J Cancer. 2008 Apr 22;98(8):1380-8
references.pmid: 18362934
references.citation: Cancer Res. 2011 Dec 15;71(24):7463-70
references.pmid: 22025564
references.citation: Blood. 2002 Aug 15;100(4):1399-403
references.pmid: 12149223
references.citation: J Clin Oncol. 2011 Mar 20;29(9):1146-50
references.pmid: 21321296
references.citation: J Clin Oncol. 2005 Mar 10;23(8):1636-43
references.pmid: 15755971
references.citation: N Engl J Med. 1986 Dec 11;315(24):1501-5
references.pmid: 3537787
references.citation: Cancer Immunol Immunother. 2007 Feb;56(2):227-36
references.pmid: 16783578
references.citation: Cancer Res. 2011 Apr 1;71(7):2664-74
references.pmid: 21324923
references.citation: Cancer Prev Res (Phila). 2009 Sep;2(9):823-9
references.pmid: 19737986
references.citation: Cancer Immunol Immunother. 2009 Apr;58(4):603-14
references.pmid: 18802697
references.citation: J Clin Oncol. 2010 Aug 1;28(22):3577-81
references.pmid: 20567021
references.citation: Clin Cancer Res. 2009 Feb 1;15(3):1046-51
references.pmid: 19188178
references.citation: N Engl J Med. 2006 Aug 31;355(9):873-84
references.pmid: 16943400
references.citation: N Engl J Med. 1999 Mar 4;340(9):737-8
references.pmid: 10068336
references.citation: BMJ. 2010 Jul 20;341:c3493
references.pmid: 20647284
references.citation: Cell Cycle. 2012 Mar 1;11(5):865-70
references.pmid: 22333588
references.citation: J Clin Invest. 2004 Sep;114(5):623-33
references.pmid: 15343380
references.citation: J Immunother. 2007 May-Jun;30(4):370-7
references.pmid: 17457212
references.citation: Ann Intern Med. 2007 Mar 6;146(5):361-4
references.pmid: 17339621
references.citation: Cancer Res. 2011 Nov 15;71(22):6965-75
references.pmid: 21948958
references.citation: Cancer Res. 2002 Mar 15;62(6):1676-81
references.pmid: 11912139
references.citation: J Clin Oncol. 2010 Oct 10;28(29):4531-8
references.pmid: 20516428
references.citation: Lancet Oncol. 2009 May;10(5):501-7
references.pmid: 19410194
references.citation: Cancer Prev Res (Phila). 2012 Apr;5(4):544-52
references.pmid: 22467080
references.citation: J Immunol. 2010 Sep 15;185(6):3498-503
references.pmid: 20729331
references.citation: Annu Rev Immunol. 2011;29:235-71
references.pmid: 21219185
references.citation: J Virol. 2011 Aug;85(16):8316-27
references.pmid: 21653670
references.citation: Br J Cancer. 2007 Jun 18;96(12):1849-54
references.pmid: 17565340
references.citation: J Clin Oncol. 2011 Feb 20;29(6):610-8
references.pmid: 21245428
references.citation: J Immunol. 2005 Dec 15;175(12):7916-29
references.pmid: 16339527
references.citation: Cancer Res. 2006 Jan 15;66(2):605-12
references.pmid: 16423985
references.citation: Oral Oncol. 2009 Aug;45(8):696-702
references.pmid: 19097930
references.citation: Anticancer Res. 2009 Nov;29(11):4615-9
references.pmid: 20032411
references.citation: EMBO J. 2004 Apr 7;23(7):1669-78
references.pmid: 15014433
references.citation: N Engl J Med. 2005 Dec 22;353(25):2654-66
references.pmid: 16371631
references.citation: Trends Immunol. 2012 May;33(5):199-206
references.pmid: 22364810
references.citation: Cancer Res. 2006 Dec 1;66(23):11238-46
references.pmid: 17114237
references.citation: Cancer Res. 2006 Sep 15;66(18):9299-307
references.pmid: 16982775
references.citation: Semin Cancer Biol. 2012 Feb;22(1):50-9
references.pmid: 22257681
references.citation: N Engl J Med. 2011 Jun 23;364(25):2381-91
references.pmid: 21639806
references.citation: Exp Gerontol. 2009 Jun-Jul;44(6-7):398-405
references.pmid: 19298850
references.citation: Cancer Res. 2007 Nov 15;67(22):11021-8
references.pmid: 18006848
references.citation: Carcinogenesis. 2011 Sep;32(9):1333-9
references.pmid: 21730361
references.citation: J Immunol. 2009 Apr 15;182(8):4499-506
references.pmid: 19342621
references.citation: Nature. 2009 Jul 2;460(7251):103-7
references.pmid: 19494812
references.citation: J Exp Med. 2003 Dec 1;198(11):1741-52
references.pmid: 14657224
references.citation: Science. 2001 Oct 19;294(5542):605-9
references.pmid: 11567106
references.citation: J Immunol. 2008 May 1;180(9):6044-53
references.pmid: 18424725
references.citation: Cancer Res. 2007 Aug 1;67(15):7450-7
references.pmid: 17671215
references.citation: Cell Mol Immunol. 2010 Jul;7(4):306-15
references.pmid: 20305684
references.citation: Blood. 2011 Nov 17;118(20):5498-505
references.pmid: 21972293
references.citation: Int J Cancer. 2009 Aug 1;125(3):541-7
references.pmid: 19431205
references.citation: J Immunol. 2005 Aug 1;175(3):1483-90
references.pmid: 16034085
references.citation: N Engl J Med. 2000 Jun 29;342(26):1946-52
references.pmid: 10874062
references.citation: N Engl J Med. 1997 Jun 26;336(26):1855-9
references.pmid: 9197213
references.citation: J Transl Med. 2011 Oct 17;9:177
references.pmid: 22005011
references.citation: Cancer Prev Res (Phila). 2010 Sep;3(9):1077-83
references.pmid: 20810669
references.citation: Cancer Prev Res (Phila). 2011 Aug;4(8):1198-208
references.pmid: 21576350
references.citation: Cancer Res. 2010 Oct 15;70(20):7800-9
references.pmid: 20924111
references.citation: Br J Cancer. 1993 Jun;67(6):1372-80
references.pmid: 8390286
references.citation: Annu Rev Immunol. 2009;27:83-117
references.pmid: 19007331
references.citation: Nat Rev Clin Oncol. 2012 Apr 03;9(5):259-67
references.pmid: 22473097
references.citation: J Am Soc Nephrol. 2010 Jan;21(1):181-8
references.pmid: 19713314
references.citation: Blood. 2000 Jun 1;95(11):3349-56
references.pmid: 10828015
references.citation: Cancer. 2009 Jan 15;115(2):454-64
references.pmid: 19110997
references.citation: J Surg Res. 2000 Apr;89(2):169-75
references.pmid: 10729246
references.citation: Cancer Prev Res (Phila). 2010 Sep;3(9):1066-76
references.pmid: 20810672
references.citation: Blood. 2003 Sep 15;102(6):2310-1
references.pmid: 12959943
references.citation: Cancer Sci. 2009 Feb;100(2):334-40
references.pmid: 19068090