title: Therapeutic polymers for dental adhesives: loading resins with bio-active components.
abstract: OBJECTIVE
  Many recent adhesives on the market exhibit reasonable clinical performance. Future innovations in adhesive materials should therefore seek out novel properties rather than simply modifying existing technologies. It is proposed that adhesive materials that are "bio-active" could contribute to better prognosis of restorative treatments.
  
  
  METHODS
  This review examines the recent approaches used to achieve therapeutic polymers for dental adhesives by incorporating bio-active components. A strategy to maintain adhesive restorations is the focus of this paper.
  
  
  RESULTS
  Major trials on therapeutic dental adhesives have looked at adding antibacterial activities or remineralization effects. Applications of antibacterial resin monomers based on quaternary ammonium compounds have received much research attention, and the loading of nano-sized bioactive particles or multiple ion-releasing glass fillers have been perceived as advantageous since they are not expected to influence the mechanical properties of the carrier polymer.
  
  
  CONCLUSIONS
  The therapeutic polymer approaches described here have the potential to provide clinical benefits. However, not many technological applications in this category have been successfully commercialized. Clinical evidence as well as further advancement of these technologies can be a driving force to make these new types of materials clinically available.
authors.affiliation: Department of Biomaterials Science, Osaka University Graduate School of Dentistry, Osaka, Japan. Electronic address: imazato@dent.osaka-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Imazato
authors.affiliation: Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
authors.forename: Sai
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
authors.forename: Ji-hua
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, USA.
authors.forename: Hockin H K
authors.initials: HH
authors.lastname: Xu
mesh_terms: D003738:Dental Cements; D003793:Dental Restoration, Permanent; D005139:Eyeglasses; D046529:Microscopy, Electron, Transmission; D011108:Polymers / Q000627:therapeutic use*
chemical_list: D003738:Dental Cements; D011108:Polymers
keywords: Adhesives; Antibacterial; Bio-active; Dental polymers; Nano-particle; QAC; Remineralization
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