title: Tolerance of a cow's milk-based hydrolyzed formula in patients with eosinophilic esophagitis triggered by milk.
abstract: BACKGROUND
  Cow's milk protein, a major food trigger for EoE in both children and adults, should be continuously avoided once identified as such. This study evaluates tolerance of a cow's milk-based extensively hydrolyzed formula (eHF) with regard to disease remission maintenance in adult patients with milk-triggered EoE.
  
  
  METHODS
  Seventeen adult patients in whom cow's milk was consecutively demonstrated to trigger EoE after an empiric six-food elimination diet-based study protocol and who subsequently maintained disease remission were prospectively recruited. They were given 400 ml of a cow's milk-based eHF daily for 8 weeks. Intraepithelial peak eosinophil and blood eosinophil counts, esophageal-related symptoms, serum total and specific IgE to major milk proteins, and eosinophil cationic protein were monitored before and after eHF intake.
  
  
  RESULTS
  Thirteen male and four female patients aged 17-56 completed the study protocol. 15 patients (88.24%) achieved and maintained EoE remission, while an infiltration of ≥15 eosinophils/hpf reappeared in the remaining two patients. No differences in age, gender, symptoms, and endoscopic appearance at baseline conditions or personal/family allergic background were observed between those patients who tolerated the eHF and those who did not. Symptom scores did not significantly change after eHF intake and were significantly lower than those documented at baseline conditions or after cow's milk challenge. No differences were documented in blood eosinophil counts or serum markers after eHF intake.
  
  
  CONCLUSIONS
  Most adult patients with EoE triggered by cow's milk tolerate a cow's milk-based eHF, thus providing them with a safe, economical alternative to cow's milk.
authors.affiliation: Department of Gastroenterology, Hospital General de Tomelloso, Ciudad Real, Spain. alucendo@vodafone.es
authors.forename: A J
authors.initials: AJ
authors.lastname: Lucendo
authors.forename: Á
authors.initials: Á
authors.lastname: Arias
authors.forename: J
authors.initials: J
authors.lastname: González-Cervera
authors.forename: T
authors.initials: T
authors.lastname: Mota-Huertas
authors.forename: J L
authors.initials: JL
authors.lastname: Yagüe-Compadre
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002417:Cattle; D057765:Eosinophilic Esophagitis / Q000178:diet therapy* / Q000276:immunology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D008875:Middle Aged; D016269:Milk Hypersensitivity / Q000178:diet therapy* / Q000276:immunology* / Q000517:prevention & control; D011446:Prospective Studies; D011492:Protein Hydrolysates / Q000627:therapeutic use*; D012074:Remission Induction; D055815:Young Adult
chemical_list: D011492:Protein Hydrolysates
keywords: eosinophilic esophagitis; food allergy; hydrolyzed formula; milk allergy; milk proteins