title: Biological soliton in multicellular movement.
abstract: Solitons have been observed in various physical phenomena. Here, we show that the distinct characteristics of solitons are present in the mass cell movement of non-chemotactic mutants of the cellular slime mould Dictyostelium discoideum. During starvation, D. discoideum forms multicellular structures that differentiate into spore or stalk cells and, eventually, a fruiting body. Non-chemotactic mutant cells do not form multicellular structures; however, they do undergo mass cell movement in the form of a pulsatile soliton-like structure (SLS). We also found that SLS induction is mediated by adhesive cell-cell interactions. These observations provide novel insights into the mechanisms of biological solitons in multicellular movement.
authors.affiliation: Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Tennodai, 1-1-1, Ibaraki 305-8572, Japan. hidekuwayama@biol.tsukuba.ac.jp
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kuwayama
authors.forename: Shuji
authors.initials: S
authors.lastname: Ishida
mesh_terms: D002110:Caffeine / Q000494:pharmacology; D002448:Cell Adhesion; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D002633:Chemotaxis / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D004023:Dictyostelium / Q000502:physiology*; D017125:Genes, Protozoan / Q000235:genetics; D006588:Hexanones / Q000378:metabolism; D009154:Mutation; D015398:Signal Transduction
chemical_list: D006588:Hexanones; C053433:1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone; D002110:Caffeine; D000242:Cyclic AMP
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