title: Bioassay-guided isolation of neo-clerodane diterpenoids from Scutellaria barbata.
abstract: Bioassay-guided isolation of the aerial part of Scutellaria barbata yielded three new neo-clerodane diterpenoids scutebatas P-R (1-3), together with two known ones: scutebata E (4) and scutebarbatine B (5). The chemical structures of the isolated compounds were elucidated by spectroscopic methods (NMR and MS) and by comparison with the spectroscopic data reported in the literature. All compounds except 3 showed weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines, and compounds 1, 2, and 5 also displayed weak activities against HL60 cell lines.
authors.affiliation: a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , 266003 , China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Li
authors.forename: Xu-Li
authors.initials: XL
authors.lastname: Tang
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Pei-Fen
authors.initials: PF
authors.lastname: Li
authors.forename: Ping-Lin
authors.initials: PL
authors.lastname: Li
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D031363:Scutellaria / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; C585691:scutebata P; C585692:scutebata Q; C585693:scutebata R