title: Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.
abstract: BACKGROUND
  It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease.
  
  
  METHODS
  We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.
  
  
  RESULTS
  We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.
  
  
  CONCLUSIONS
  Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Scientific-Research Centre, Sechenov First Moscow State Medical University, Moscow, Russia. azimova.j@mail.ru
authors.forename: Julia E
authors.initials: JE
authors.lastname: Azimova
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Sergeev
authors.forename: Liubov A
authors.initials: LA
authors.lastname: Korobeynikova
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Kondratieva
authors.forename: Zarema G
authors.initials: ZG
authors.lastname: Kokaeva
authors.forename: Gadji O
authors.initials: GO
authors.lastname: Shaikhaev
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Skorobogatykh
authors.forename: Natalia M
authors.initials: NM
authors.lastname: Fokina
authors.forename: Gyusal R
authors.initials: GR
authors.lastname: Tabeeva
authors.forename: Eugene A
authors.initials: EA
authors.lastname: Klimov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004252:DNA Mutational Analysis; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020325:Migraine with Aura / Q000235:genetics* / Q000503:physiopathology; D020326:Migraine without Aura / Q000235:genetics* / Q000503:physiopathology; D010775:Photic Stimulation; D011110:Polymorphism, Genetic / Q000235:genetics*; D055815:Young Adult
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
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