title: Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during HIV-associated tuberculosis.
abstract: The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCG-immunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.
authors.affiliation: Geisel School of Medicine at Dartmouth.
authors.forename: Timothy
authors.initials: T
authors.lastname: Lahey
authors.forename: Tom
authors.initials: T
authors.lastname: Czechura
authors.forename: Scott
authors.initials: S
authors.lastname: Crabtree
authors.forename: Robert D
authors.initials: RD
authors.lastname: Arbeit
authors.forename: Mecky
authors.initials: M
authors.lastname: Matee
authors.forename: C Robert
authors.initials: CR
authors.lastname: Horsburgh
authors.forename: Todd
authors.initials: T
authors.lastname: MacKenzie
authors.forename: Muhammad
authors.initials: M
authors.lastname: Bakari
authors.forename: Kisali
authors.initials: K
authors.lastname: Pallangyo
authors.forename: C Fordham
authors.initials: CF
authors.lastname: von Reyn
mesh_terms: D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology*; D001500:BCG Vaccine / Q000276:immunology*; D058491:Bacterial Load; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology*; D059425:Interferon-gamma Release Tests; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013183:Sputum / Q000276:immunology / Q000382:microbiology; D013636:Tanzania; D014376:Tuberculosis / Q000150:complications* / Q000382:microbiology / Q000517:prevention & control*; D019562:Viral Load; D055815:Young Adult
chemical_list: D000942:Antigens, Bacterial; D001500:BCG Vaccine; D007371:Interferon-gamma
keywords: HIV; antigen; interferon gamma; tuberculosis; vaccine
references.citation: N Engl J Med. 1996 Dec 26;335(26):1956-61
references.pmid: 8960475
references.citation: Lancet. 2001 Oct 20;358(9290):1348
references.pmid: 11684228
references.citation: Eur Respir J. 2010 Sep;36(3):594-600
references.pmid: 20075047
references.citation: PLoS One. 2012;7(5):e37436
references.pmid: 22629395
references.citation: N Engl J Med. 1999 Feb 4;340(5):367-73
references.pmid: 9929528
references.citation: AIDS. 2010 Mar 13;24(5):675-85
references.pmid: 20118767
references.citation: Clin Infect Dis. 2004 Mar 1;38(5):754-6
references.pmid: 14986262
references.citation: J Infect Dis. 2010 Oct 15;202(8):1265-72
references.pmid: 20812851
references.citation: Int J Tuberc Lung Dis. 2008 Sep;12(9):1037-41
references.pmid: 18713501
references.citation: Am J Respir Crit Care Med. 2013 May 1;187(9):1007-15
references.pmid: 23306539
references.citation: PLoS One. 2011;6(7):e22074
references.pmid: 21799772
references.citation: Clin Infect Dis. 2004 Mar 1;38(5):757-9
references.pmid: 14986263
references.citation: Vaccine. 2010 Nov 10;28(48):7652-8
references.pmid: 20875492