title: Management of unruptured intracranial aneurysms.
abstract: Unruptured intracranial aneurysms (UIA) are a common finding, occurring in about 2% of the population, making them very likely to be seen by most practitioners, and present a challenge in the recommendations for optimal management and screening. The consequences of aneurysm rupture are dire, with high likelihood of significant morbidity and mortality. Most aneurysms do not rupture and patients harboring these lesions often remain asymptomatic. There are effective surgical and endovascular interventions to prevent rupture, but these procedures carry a risk of adverse complications. This article addresses the challenges of screening and management of UIAs.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN.
authors.forename: Lindsy N
authors.initials: LN
authors.lastname: Williams
authors.forename: Robert D
authors.initials: RD
authors.lastname: Brown
references.citation: J Neurosurg. 1999 Sep;91(3):396-401
references.pmid: 10470813
references.citation: J Vasc Surg. 2011 Mar;53(3):826-36.e1
references.pmid: 21236620
references.citation: J Neurosurg. 1990 Dec;73(6):859-63
references.pmid: 2230969
references.citation: J Neurosurg. 1994 Dec;81(6):837-42
references.pmid: 7965113
references.citation: Lancet. 2003 Jul 12;362(9378):103-10
references.pmid: 12867109
references.citation: Lancet. 2007 Jan 27;369(9558):306-18
references.pmid: 17258671
references.citation: Lancet. 2005 Sep 3-9;366(9488):809-17
references.pmid: 16139655
references.citation: Neurology. 1999 Sep 22;53(5):982-8
references.pmid: 10496256
references.citation: Arch Neurol. 1993 Mar;50(3):265-8
references.pmid: 8442705
references.citation: J Neurosurg. 2004 Dec;101(6):921-5
references.pmid: 15597751
references.citation: Stroke. 2009 Feb;40(2):406-11
references.pmid: 19023101
references.citation: Stroke. 1998 Aug;29(8):1531-8
references.pmid: 9707188
references.citation: Neurosurg Focus. 2001 Aug 15;11(2):E4
references.pmid: 16602677
references.citation: Stroke. 2011 Jan;42(1):204-6
references.pmid: 21164130
references.citation: N Engl J Med. 1999 Oct 28;341(18):1344-50
references.pmid: 10536126
references.citation: Lancet Neurol. 2011 Jul;10(7):626-36
references.pmid: 21641282
references.citation: N Engl J Med. 2012 Jun 28;366(26):2474-82
references.pmid: 22738097
references.citation: Neurology. 2004 Feb 10;62(3):369-75
references.pmid: 14872015
references.citation: Stroke. 2011 Nov;42(11):3156-62
references.pmid: 21980208
references.citation: Stroke. 2010 Sep;41(9):1969-77
references.pmid: 20671254
references.citation: Radiology. 2012 Jun;263(3):828-35
references.pmid: 22623696
references.citation: Lancet Neurol. 2009 Jul;8(7):635-42
references.pmid: 19501022
references.citation: Radiology. 2010 Sep;256(3):887-97
references.pmid: 20634431
references.citation: Stroke. 2007 Apr;38(4):1404-10
references.pmid: 17332442
references.citation: AJNR Am J Neuroradiol. 2011 Jun-Jul;32(6):1071-5
references.pmid: 21511860
references.citation: Stroke. 1997 Jan;28(1):6-9
references.pmid: 8996479
references.citation: Mayo Clin Proc. 2003 Dec;78(12):1491-9
references.pmid: 14661678
references.citation: J Neurosurg. 2008 Jun;108(6):1132-8
references.pmid: 18518716
references.citation: Circulation. 2000 Oct 31;102(18):2300-8
references.pmid: 11056108
references.citation: Arch Neurol. 2001 Apr;58(4):559-64
references.pmid: 11295985
references.citation: Stroke. 1998 Feb;29(2):359-62
references.pmid: 9472874
references.citation: Lancet Neurol. 2005 Feb;4(2):122-8
references.pmid: 15664544
references.citation: J Thromb Haemost. 2010 Jul;8(7):1468-74
references.pmid: 20345728
references.citation: J Neurointerv Surg. 2013 Sep 1;5(5):405-9
references.pmid: 22679130