title: Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.
abstract: The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.
authors.affiliation: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.
authors.forename: Duncan
authors.initials: D
authors.lastname: Wilson
authors.forename: Betty
authors.initials: B
authors.lastname: Hebecker
authors.forename: David L
authors.initials: DL
authors.lastname: Moyes
authors.forename: Pedro
authors.initials: P
authors.lastname: Miramón
authors.forename: Nadja
authors.initials: N
authors.lastname: Jablonowski
authors.forename: Stephanie
authors.initials: S
authors.lastname: Wisgott
authors.forename: Stefanie
authors.initials: S
authors.lastname: Allert
authors.forename: Julian R
authors.initials: JR
authors.lastname: Naglik
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hube
mesh_terms: D002176:Candida albicans / Q000187:drug effects / Q000472:pathogenicity; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000276:immunology; D002460:Cell Line; D003022:Clotrimazole / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D020556:Neutrophil Infiltration / Q000187:drug effects*
chemical_list: D003022:Clotrimazole
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