title: Directing transcription to the right way.
abstract: How cells ensure that productive transcription from divergent promoters is limited to the downstream protein-coding region is an important question in the transcription field. A recent study in Nature proposed an answer by revealing that the upstream antisense transcripts undergo early termination through the polyadenylation signal-dependent pathway, and the downstream sense transcripts are protected from premature cleavage by U1 small nuclear ribonucleoprotein (snRNP).
authors.affiliation: Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
authors.forename: Fu
authors.initials: F
authors.lastname: Huang
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Workman
mesh_terms: D000818:Animals; D006801:Humans; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism; D016372:RNA, Antisense / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000378:metabolism; D015398:Signal Transduction; D015533:Transcriptional Activation
chemical_list: D016372:RNA, Antisense; D012333:RNA, Messenger; D017412:Ribonucleoprotein, U1 Small Nuclear; D012319:RNA Polymerase II
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