title: Toxicity of manganese metallodrugs toward Danio rerio.
abstract: Manganese is an essential metal which can be neurotoxic in some instances. As Mn-based metallodrugs are ever more prevalent in clinical practice, concern regarding the toxic effects of Mn discharges to water bodies on the biota prompted us to study the physicochemical parameters of these complexes and to assess their acute toxicity toward adult Danio rerio individuals, particularly in terms of brain tissue damage. Our results show that the Mn(III)-salen acetate complex EUK108 is toxic, which can be rationalized in terms of its lipophilicity, stability and redox activity.
authors.affiliation: Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo, Brazil.
authors.forename: Anderson
authors.initials: A
authors.lastname: Arndt
authors.forename: Maria Inês
authors.initials: MI
authors.lastname: Borella
authors.forename: Breno Pannia
authors.initials: BP
authors.lastname: Espósito
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D008345:Manganese / Q000633:toxicity*; D009942:Organometallic Compounds / Q000633:toxicity; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations; D018570:Risk Assessment; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish
chemical_list: D009942:Organometallic Compounds; D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical; D008345:Manganese
keywords: Danio rerio; Manganese; Metallodrug; Toxicity