title: Highly aggressive pathology of non-functional parathyroid carcinoma.
abstract: Parathyroid carcinoma is a rare malignant endocrine tumor accounting for only 0.5% to 5% of all primary hyperparathyroidism. Among these malignancies, only 10-25% are nonfunctioning. After the review of the literature we could only ascertain a number of 25 cases reported worldwide, since 1929, our case being the 26th, but the first with a very aggressive pathology, treated with chemotherapy scheme usually used for neuroendocrine tumors. Considering these facts, every single case presented is a step forward in defying the clinical presentation, for the awareness of the clinicians, and also in establishing standard adjuvant therapies.
authors.affiliation: Department of Nuclear Medicine and Endocrine Tumours, Ion Chiricuţă Institute of Oncology, 34-36, Republicii St, 400015, Cluj-Napoca, România. doina.piciu@gmail.com
authors.forename: Doina
authors.initials: D
authors.lastname: Piciu
authors.forename: Alexandru
authors.initials: A
authors.lastname: Irimie
authors.forename: George
authors.initials: G
authors.lastname: Kontogeorgos
authors.forename: Andra
authors.initials: A
authors.lastname: Piciu
authors.forename: Rares
authors.initials: R
authors.lastname: Buiga
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005047:Etoposide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016105:Parathyroidectomy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D016190:Carboplatin
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