title: Evaluation of gadolinium-EOB-DTPA uptake after portal vein embolization: value of an increased flip angle.
abstract: BACKGROUND
  The optimal sequence for Gd-EOB-DTPA uptake measurement in the liver with the purpose of liver function measurement is still not defined.
  
  
  OBJECTIVE
  To prospectively evaluate the effect of an increased flip angle (FA) of a T1-weighted fat-saturated 3D sequence for the measurement of hepatocyte uptake of Gd-EOB-DTPA magnetic resonance imaging (MRI) after right portal vein embolization (PVE).
  
  
  METHODS
  Ten patients who received a PVE prior to an extended hemihepatectomy were examined 14 days after PVE using Gd-EOB-DTPA enhanced MRI of the liver using the standard FA of 10° and the increased FA of 30°.
  
  
  RESULTS
  Relative enhancement of the right liver lobe (RLL) was 0.52 ± 0.12 for 10° and 1.41 ± 0.39 for 30°. Relative enhancement of the left liver lobe (LLL) was 0.58 ± 0.11 for 10° and 2.05 ± 0.61 for 30°. Relative enhancement of the RLL was significantly higher for 30° than for 10° (P = 0.009) and significantly higher in the 30° than in the 10° sequences (P = 0.005) for the LLL.
  
  
  CONCLUSIONS
  A flip angle of 30° increases the contrast between liver partitions with and without portal venous embolization. Thereby, the sensitivity for differences in uptake intensity is increased. This could be of value for a more exact determination of differences in regional liver function and, consequently, the estimation of the future remnant liver function.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Charité, Campus Virchow-Klinikum, Berlin, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Geisel
authors.forename: Lutz
authors.initials: L
authors.lastname: Lüdemann
authors.forename: Clemens
authors.initials: C
authors.lastname: Wagner
authors.forename: Lars
authors.initials: L
authors.lastname: Stelter
authors.forename: Christian
authors.initials: C
authors.lastname: Grieser
authors.forename: Maciej
authors.initials: M
authors.lastname: Malinowski
authors.forename: Martin
authors.initials: M
authors.lastname: Stockmann
authors.forename: Daniel
authors.initials: D
authors.lastname: Seehofer
authors.forename: Bernd
authors.initials: B
authors.lastname: Hamm
authors.forename: Bernhard
authors.initials: B
authors.lastname: Gebauer
authors.forename: Timm
authors.initials: T
authors.lastname: Denecke
mesh_terms: D000328:Adult; D000368:Aged; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000628:therapy; D003287:Contrast Media / Q000493:pharmacokinetics*; D004621:Embolization, Therapeutic; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Gd-EOB-DTPA; MRI; flip angle; liver function; portal vein embolization