title: [Research progress in the structure and fuction of Orthopoxvirus host range genes].
abstract: Orthopoxvirus vector has a broad prospect in recombinant vaccine research, but the rarely severe side-effect impedes its development. Vaccinia virus and Cowpox virus of Orthopoxvirus have broad host range, and they have typical host range genes as K1L, CP77 and C7L. These three genes affect host range of Vaccinia virus, disturb the cell signaling pathways, suppress immune response and are related to virulence.
authors.affiliation: China Center for Disease Control and Prevention, Beijing 102206, China. 285022750@qq.com
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shao
mesh_terms: D002460:Cell Line; D015608:Cowpox virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D005822:Genetic Vectors; D058507:Host Specificity / Q000235:genetics*; D018155:Orthopoxvirus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D015398:Signal Transduction; D014614:Vaccines, Synthetic / Q000276:immunology; D014616:Vaccinia virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*; D014765:Viral Vaccines / Q000276:immunology*; D014774:Virulence
chemical_list: C082283:C7L protein, Vaccinia virus; C083205:K1L protein, Vaccinia virus; D014614:Vaccines, Synthetic; D014764:Viral Proteins; D014765:Viral Vaccines