title: Biosynthesis: a sulfonate relay revealed.
abstract: Biological sulfonate incorporation is mediated by 3′-phosphoadenosine-5′-phosphosulfate-dependent sulfotransferases and, to a lesser extent, arylsulfate sulfotransferases. An unusual two-enzyme strategy for sulfonate mobilization involving both types of sulfotransferases has been revealed during antibiotic biosynthesis, which uses a new polyketide as the sulfonate shuttle.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Van Lanen
mesh_terms: D000217:Acyltransferases / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D013431:Sulfates / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D013431:Sulfates; D000217:Acyltransferases; C020141:flavanone synthetase
references.citation: Chem Biol. 2002 Jul;9(7):767-76
references.pmid: 12144918
references.citation: Arch Biochem Biophys. 1986 Mar;245(2):537-9
references.pmid: 3456739
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19217-22
references.pmid: 19036922
references.citation: Curr Opin Drug Discov Devel. 2000 Sep;3(5):502-15
references.pmid: 19649879
references.citation: J Bacteriol. 2013 Jan;195(1):167-71
references.pmid: 23104813
references.citation: Nat Chem Biol. 2013 Oct;9(10):610-5
references.pmid: 23912167
references.citation: Antioxid Redox Signal. 2010 Oct;13(8):1247-59
references.pmid: 20136513
references.citation: ACS Chem Biol. 2012 Dec 21;7(12):1994-2003
references.pmid: 22991895
references.citation: J Biol Chem. 2010 Apr 23;285(17):12684-94
references.pmid: 20157116
references.citation: Chembiochem. 2010 Jan 25;11(2):184-90
references.pmid: 20043306