title: Association between tumor necrosis factor β 252 A/G polymorphism and risk of gastric cancer: a meta-analysis.
abstract: Tumor necrosis factor β (TNF-β) 252 A/G polymorphism has been implicated to be associated with risk of gastric cancer, but previous studies showed inconsistent and inconclusive results. Therefore, we performed a meta-analysis to assess the association between TNF-β 252 A/G polymorphism and gastric cancer risk. Relevant studies were searched from PubMed database. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of the associations between TNF-β 252 A/G polymorphism and gastric cancer risk. Overall, 11 individual case-control studies with 2,270 cases and 4,404 controls were included in the final meta-analysis. Meta-analysis of total 11 studies showed that TNF-β 252 A/G polymorphism was associated with the risk of gastric cancer (G vs. A: OR = 1.10, 95% CI 1.02-1.19, P = 0.015; GG/AG vs. AA: OR = 1.21, 95% CI 1.00-1.47, P = 0.049). Subgroup analysis by ethnicity showed that TNF-β 252 A/G polymorphism was only associated with the risk of gastric cancer in Asians, but not Caucasians. The findings from the current meta-analysis suggest that TNF-β 252 A/G polymorphism is associated with the risk of gastric cancer, especially in Asians.
authors.affiliation: Department of Gastroenterology, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen, 518000, Guangdong Province, China.
authors.forename: Zhenglei
authors.initials: Z
authors.lastname: Xu
authors.forename: Ruiyue
authors.initials: R
authors.lastname: Shi
authors.forename: Ru
authors.initials: R
authors.lastname: Zhang
authors.forename: Dingguo
authors.initials: D
authors.lastname: Zhang
authors.forename: Lisheng
authors.initials: L
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D008233:Lymphotoxin-alpha
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