title: Obligatory role for the immediate early gene NARP in critical period plasticity.
abstract: The immediate early gene neuronal activity-regulated pentraxin (NARP) is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) binding protein that is specifically enriched at excitatory synapses onto fast-spiking parvalbumin-positive interneurons (FS [PV] INs). Here, we show that transgenic deletion of NARP decreases the number of excitatory synaptic inputs onto FS (PV) INs and reduces net excitatory synaptic drive onto FS (PV) INs. Accordingly, the visual cortex of NARP(-/-) mice is hyperexcitable and unable to express ocular dominance plasticity, although many aspects of visual function are unimpaired. Importantly, the number and strength of inhibitory synaptic contacts from FS (PV) INs onto principle neurons in the visual cortex is normal in NARP(-/-) mice, and enhancement of this output recovers the expression of experience-dependent synaptic plasticity. Thus the recruitment of inhibition from FS (PV) INs plays a central role in enabling the critical period for ocular dominance plasticity.
authors.affiliation: Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, MD 20742, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Gu
authors.forename: Shiyong
authors.initials: S
authors.lastname: Huang
authors.forename: Michael C
authors.initials: MC
authors.lastname: Chang
authors.forename: Paul
authors.initials: P
authors.lastname: Worley
authors.forename: Alfredo
authors.initials: A
authors.lastname: Kirkwood
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Quinlan
mesh_terms: D000200:Action Potentials / Q000235:genetics; D000818:Animals; D002097:C-Reactive Protein / Q000172:deficiency* / Q000235:genetics*; D003423:Critical Period, Psychological; D023882:Dominance, Ocular / Q000235:genetics; D017781:Genes, Immediate-Early / Q000502:physiology*; D051379:Mice; D057507:Mice, 129 Strain; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000172:deficiency* / Q000235:genetics*; D009473:Neuronal Plasticity / Q000235:genetics*; D014793:Visual Cortex / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D009419:Nerve Tissue Proteins; D000099153:Pentraxins
references.citation: Curr Biol. 2011 May 24;21(10):876-82
references.pmid: 21549600
references.citation: Nature. 1987 Dec 17-23;330(6149):649-52
references.pmid: 2446147
references.citation: Cell. 2008 Aug 8;134(3):508-20
references.pmid: 18692473
references.citation: Brain Res Bull. 2008 May 15;76(1-2):97-101
references.pmid: 18395617
references.citation: J Neurosci. 1996 Apr 15;16(8):2463-78
references.pmid: 8786423
references.citation: Eur J Neurosci. 2003 Jan;17(1):167-73
references.pmid: 12534981
references.citation: J Neurosci. 2008 Oct 8;28(41):10278-86
references.pmid: 18842887
references.citation: Eur J Neurosci. 2007 Feb;25(3):795-804
references.pmid: 17328775
references.citation: Neuron. 2010 Apr 29;66(2):248-59
references.pmid: 20435001
references.citation: Proc Natl Acad Sci U S A. 2006 May 30;103(22):8517-22
references.pmid: 16709670
references.citation: Neuron. 2003 Jun 19;38(6):977-85
references.pmid: 12818182
references.citation: Cell. 1999 Sep 17;98(6):739-55
references.pmid: 10499792
references.citation: J Neurosci. 2010 Jan 27;30(4):1551-9
references.pmid: 20107082
references.citation: Neuron. 2003 Jul 31;39(3):513-28
references.pmid: 12895424
references.citation: J Neurosci. 2007 Sep 5;27(36):9648-52
references.pmid: 17804625
references.citation: Vision Res. 1994 Mar;34(6):709-20
references.pmid: 8160387
references.citation: J Neurosci. 2010 Dec 8;30(49):16636-42
references.pmid: 21148002
references.citation: Nat Neurosci. 2010 Oct;13(10):1240-8
references.pmid: 20871602
references.citation: Nat Neurosci. 2010 Sep;13(9):1090-7
references.pmid: 20729843
references.citation: Biophys J. 2001 Oct;81(4):1970-89
references.pmid: 11566771
references.citation: Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1311-6
references.pmid: 22232689
references.citation: J Neurosci. 2010 Dec 1;30(48):16304-13
references.pmid: 21123576
references.citation: Neuron. 2008 May 8;58(3):387-400
references.pmid: 18466749
references.citation: Science. 1998 Nov 20;282(5393):1504-8
references.pmid: 9822384
references.citation: Nat Neurosci. 2007 Jun;10(6):679-81
references.pmid: 17468749
references.citation: Nat Neurosci. 2005 Mar;8(3):380-8
references.pmid: 15723060
references.citation: J Neurosci. 2006 Jun 7;26(23):6269-81
references.pmid: 16763034
references.citation: J Neurosci. 1996 May 15;16(10):3274-86
references.pmid: 8627365
references.citation: Neuron. 2004 Dec 16;44(6):917-23
references.pmid: 15603735
references.citation: Nat Neurosci. 2011 Jul 12;14(9):1121-3
references.pmid: 21750548
references.citation: Neuron. 1999 Jun;23(2):309-23
references.pmid: 10399937
references.citation: Nat Neurosci. 2007 Sep;10(9):1134-6
references.pmid: 17694050
references.citation: Nature. 2009 Nov 12;462(7270):218-21
references.pmid: 19907494
references.citation: Learn Mem. 2004 Nov-Dec;11(6):738-47
references.pmid: 15537732
references.citation: Science. 2002 Nov 8;298(5596):1248-51
references.pmid: 12424383
references.citation: J Neurosci. 2002 Jul 1;22(13):5271-6
references.pmid: 12097476
references.citation: PLoS One. 2008 Sep 01;3(9):e3120
references.pmid: 18769674
references.citation: Cereb Cortex. 1997 Sep;7(6):476-86
references.pmid: 9276173
references.citation: Vision Res. 2004 Dec;44(28):3411-8
references.pmid: 15536009
references.citation: J Neurosci. 2006 Mar 15;26(11):2951-5
references.pmid: 16540572
references.citation: Vision Res. 1999 Sep;39(18):3071-81
references.pmid: 10664805
references.citation: J Neurosci. 1994 Mar;14(3 Pt 2):1634-45
references.pmid: 8126560
references.citation: Philos Trans R Soc Lond B Biol Sci. 2009 Feb 12;364(1515):357-67
references.pmid: 18977732
references.citation: J Neurosci. 2009 May 20;29(20):6514-25
references.pmid: 19458222
references.citation: Neuron. 2006 Aug 3;51(3):339-49
references.pmid: 16880128
references.citation: Science. 2001 Aug 10;293(5532):1159-63
references.pmid: 11498596
references.citation: J Neurophysiol. 2009 Jan;101(1):269-75
references.pmid: 18971296
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16797-802
references.pmid: 18940923
references.citation: J Neurosci. 2001 Sep 1;21(17):6791-801
references.pmid: 11517267
references.citation: Neuroscience. 2009 Jun 30;161(2):561-71
references.pmid: 19327388
references.citation: Pharmacol Rev. 1995 Jun;47(2):181-234
references.pmid: 7568326
references.citation: PLoS Comput Biol. 2010 Jun 03;6(6):e1000797
references.pmid: 20532211
references.citation: Nat Neurosci. 2007 Mar;10(3):370-5
references.pmid: 17293862
references.citation: Learn Mem. 2007 Apr 06;14(4):277-86
references.pmid: 17522016
references.citation: Nat Rev Neurosci. 2008 Jul;9(7):557-68
references.pmid: 18568015
references.citation: J Neurosci. 2010 Jan 6;30(1):361-71
references.pmid: 20053917
references.citation: Proc Natl Acad Sci U S A. 2001 May 22;98(11):6453-8
references.pmid: 11344259
references.citation: Nature. 2000 Mar 9;404(6774):183-6
references.pmid: 10724170
references.citation: Nature. 2006 Sep 7;443(7107):81-4
references.pmid: 16929304
references.citation: J Neurosci. 2002 Sep 15;22(18):8084-90
references.pmid: 12223562
references.citation: Nat Neurosci. 2007 Dec;10(12):1569-77
references.pmid: 18026099
references.citation: Nat Neurosci. 2010 Apr;13(4):450-7
references.pmid: 20228806
references.citation: Neuron. 2009 Jan 15;61(1):35-41
references.pmid: 19146811