title: Quantitative assessment of 2q35-rs13387042 polymorphism and hormone receptor status with breast cancer risk.
abstract: BACKGROUND
  The association between rs13387042 polymorphism on 2q35 and breast cancer (BC) has been widely evaluated since it was first identified through genome-wide association approach. However, the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the relationship between the 2q35-rs13387042 polymorphism and BC.
  
  
  METHODS
  Databases including MEDLINE, PubMed, EMBASE, ISI web of science and CNKI (China National Knowledge Infrastructure) were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The random-effects model was applied, addressing heterogeneity and publication bias.
  
  
  RESULTS
  A total of 24 articles involving 99,772 cases and 164,985 controls were included. In a combined analysis, the summary per-allele odds ratio (OR) for BC of 2q35-rs13387042 polymorphism was 1.13 (95% CI: 1.11-1.16; P<10(-5)). Significant associations were also detected under co-dominant, dominant and recessive genetic models. In the subgroup analysis by ethnicity, significantly increased risks were found in Asians, Caucasians and Hispanic whites for the polymorphism in all comparisons; whereas no significant associations were found among Africans. In addition, we find 2q35-rs13387042 polymorphism conferred significantly risks for both ER-positive and ER-negative tumors. Furthermore, significant associations were also detected both in PR-positive and PR-negative cancer.
  
  
  CONCLUSIONS
  Our findings demonstrated that rs13387042-A allele is a risk-conferring factors for the development of BC, especially in Asians, Caucasians and Hispanic whites.
authors.affiliation: Department of General Surgery, Jinshan Hospital, Fudan University, Shanghai, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Gu
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Jianping
authors.initials: J
authors.lastname: Yu
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011987:Receptors, Steroid / Q000378:metabolism*
chemical_list: D011987:Receptors, Steroid
references.citation: Cancer Epidemiol Biomarkers Prev. 2011 Sep;20(9):1950-9
references.pmid: 21795501
references.citation: Ann Intern Med. 2009 Aug 18;151(4):264-9, W64
references.pmid: 19622511
references.citation: JAMA. 2006 Mar 22;295(12):1379-88
references.pmid: 16551709
references.citation: Future Oncol. 2012 Jun;8(6):697-702
references.pmid: 22764767
references.citation: Nat Genet. 2007 Jul;39(7):870-4
references.pmid: 17529973
references.citation: Mutagenesis. 2011 Mar;26(2):309-14
references.pmid: 21059810
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Nat Genet. 2009 Mar;41(3):324-8
references.pmid: 19219042
references.citation: Breast Cancer Res. 2012 Jan 23;14(1):R17
references.pmid: 22269215
references.citation: Cancer Epidemiol. 2009 Nov;33(5):315-8
references.pmid: 19896917
references.citation: Breast Cancer Res Treat. 2012 Oct;135(3):715-24
references.pmid: 22910930
references.citation: Breast Cancer Res Treat. 2011 Sep;129(2):531-9
references.pmid: 21475998
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: Breast Cancer Res Treat. 2011 Apr;126(3):717-27
references.pmid: 20872241
references.citation: Breast Cancer Res Treat. 2012 Apr;132(2):711-21
references.pmid: 22160591
references.citation: Breast Cancer Res Treat. 2011 Jul;128(1):251-7
references.pmid: 21197568
references.citation: Biometrics. 1994 Dec;50(4):1088-101
references.pmid: 7786990
references.citation: J Natl Cancer Inst. 2011 Aug 17;103(16):1252-63
references.pmid: 21791674
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2761-4
references.pmid: 19789366
references.citation: Breast Cancer Res. 2012 Mar 20;14(2):R54
references.pmid: 22433456
references.citation: N Engl J Med. 2000 Jul 13;343(2):78-85
references.pmid: 10891514
references.citation: Hum Mol Genet. 2009 Nov 15;18(22):4442-56
references.pmid: 19656774
references.citation: Nat Genet. 2008 Jun;40(6):703-6
references.pmid: 18438407
references.citation: Br J Cancer. 2012 Jan 17;106(2):389-96
references.pmid: 22045194
references.citation: PLoS Genet. 2008 Apr 25;4(4):e1000054
references.pmid: 18437204
references.citation: Hum Mol Genet. 2011 Nov 15;20(22):4491-503
references.pmid: 21852243
references.citation: Carcinogenesis. 2010 Aug;31(8):1417-23
references.pmid: 20554749
references.citation: Breast Cancer Res Treat. 2012 Dec;136(3):847-57
references.pmid: 23117855
references.citation: J Oncol. 2010;2010:595167
references.pmid: 21253541
references.citation: Nature. 2007 Jun 28;447(7148):1087-93
references.pmid: 17529967
references.citation: J Natl Cancer Inst. 2011 Mar 2;103(5):425-35
references.pmid: 21263130
references.citation: Breast Cancer Res. 2012 Mar 27;14(2):R56
references.pmid: 22452962
references.citation: Nat Genet. 2007 Jul;39(7):865-9
references.pmid: 17529974
references.citation: Anticancer Res. 2012 Feb;32(2):475-82
references.pmid: 22287734
references.citation: Carcinogenesis. 2012 Apr;33(4):835-40
references.pmid: 22357627
references.citation: Cancer Res. 2011 Oct 1;71(19):6240-9
references.pmid: 21844186
references.citation: JAMA. 2010 Jul 28;304(4):426-34
references.pmid: 20664043
references.citation: Hum Mol Genet. 2006 Jun 15;15(12):1995-2002
references.pmid: 16687441
references.citation: Breast Cancer Res Treat. 2013 Jan;137(2):511-22
references.pmid: 23184080
references.citation: Stat Med. 1999 Oct 30;18(20):2693-708
references.pmid: 10521860
references.citation: J Natl Cancer Inst. 2009 Jul 15;101(14):1012-8
references.pmid: 19567422
references.citation: Breast Cancer Res Treat. 2011 Jan;125(2):479-87
references.pmid: 20549339
references.citation: J Natl Cancer Inst. 2010 Jul 7;102(13):972-81
references.pmid: 20484103
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12629-33
references.pmid: 20616022
references.citation: Breast Cancer Res. 2011;13(6):R114
references.pmid: 22087758