title: Fragment-based hit identification: thinking in 3D.
abstract: The identification of high-quality hits during the early phases of drug discovery is essential if projects are to have a realistic chance of progressing into clinical development and delivering marketed drugs. As the pharmaceutical industry goes through unprecedented change, there are increasing opportunities to collaborate via pre-competitive networks to marshal multifunctional resources and knowledge to drive impactful, innovative science. The 3D Fragment Consortium is developing fragment-screening libraries with enhanced 3D characteristics and evaluating their effect on the quality of fragment-based hit identification (FBHI) projects.
authors.affiliation: College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, UK. Electronic address: a.morley@dundee.ac.uk.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Morley
authors.forename: Angelo
authors.initials: A
authors.lastname: Pugliese
authors.forename: Kristian
authors.initials: K
authors.lastname: Birchall
authors.forename: Justin
authors.initials: J
authors.lastname: Bower
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Nathan
authors.initials: N
authors.lastname: Brown
authors.forename: Tim
authors.initials: T
authors.lastname: Chapman
authors.forename: Martin
authors.initials: M
authors.lastname: Drysdale
authors.forename: Ian H
authors.initials: IH
authors.lastname: Gilbert
authors.forename: Swen
authors.initials: S
authors.lastname: Hoelder
authors.forename: Allan
authors.initials: A
authors.lastname: Jordan
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Andy
authors.initials: A
authors.lastname: Merritt
authors.forename: David
authors.initials: D
authors.lastname: Miller
authors.forename: Martin E
authors.initials: ME
authors.lastname: Swarbrick
authors.forename: Paul G
authors.initials: PG
authors.lastname: Wyatt
mesh_terms: D003299:Cooperative Behavior; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D004345:Drug Industry / Q000458:organization & administration / Q000639:trends; D006801:Humans; D008968:Molecular Conformation; D054852:Small Molecule Libraries / Q000737:chemistry*
chemical_list: D054852:Small Molecule Libraries