title: Evaluation of the clinical performance of the cobas 4800 HPV test in patients referred for colposcopy.
abstract: The clinical performance of the cobas human papillomavirus (HPV) test for detection of high-grade disease in a colposcopy-referred population was compared with that of Hybrid Capture 2 (HC2). The overall agreement between the tests was 92.3%. Clinical sensitivity and specificity for detection of cervical intraepithelial neoplasia grade 2 or greater (CIN2+) were 90.0% and 55.5% for cobas and 90.5% and 50.2% for HC2, respectively. In conclusion, both tests showed comparable performance for detection of CIN2+.
authors.affiliation: Department of Histopathology, Trinity College Dublin, Dublin, Ireland.
authors.forename: Christine
authors.initials: C
authors.lastname: White
authors.forename: Helen
authors.initials: H
authors.lastname: Keegan
authors.forename: Loretto
authors.initials: L
authors.lastname: Pilkington
authors.forename: Carmel
authors.initials: C
authors.lastname: Ruttle
authors.forename: Patrick
authors.initials: P
authors.lastname: Kerr
authors.forename: Linda
authors.initials: L
authors.lastname: Sharp
authors.forename: Sharon
authors.initials: S
authors.lastname: O'Toole
authors.forename: Michael
authors.initials: M
authors.lastname: Turner
authors.forename: Walter
authors.initials: W
authors.lastname: Prendiville
authors.forename: Tom
authors.initials: T
authors.lastname: D'Arcy
authors.forename: Myra
authors.initials: M
authors.lastname: Fitzpatrick
authors.forename: Peter
authors.initials: P
authors.lastname: Lenehan
authors.forename: Grainne
authors.initials: G
authors.lastname: Flannelly
authors.forename: John J
authors.initials: JJ
authors.lastname: O'Leary
authors.forename: Cara M
authors.initials: CM
authors.lastname: Martin
mesh_terms: D000328:Adult; D003127:Colposcopy; D005260:Female; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000821:virology*; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000821:virology; D014773:Virology / Q000379:methods*; D002578:Uterine Cervical Dysplasia / Q000821:virology
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