title: Practical considerations for the dosing and adjustment of continuous renal replacement therapy in the intensive care unit.
abstract: Familiarity with the initiation, dosing, adjustment, and termination of continuous renal replacement therapy (CRRT) is a core skill for contemporary intensivists. Guidelines for how to administer CRRT in the intensive care unit are not well documented. The purpose of this review is to discuss the modalities, terminology, and components of CRRT, with an emphasis on the practical aspects of dosing, adjustments, and termination. Management of electrolyte and acid-base derangements commonly encountered with acute renal failure is emphasized. Knowledge regarding the practical aspects of managing CRRT in the intensive care unit is a prerequisite for achieving desired physiological end points.
authors.affiliation: Division of Critical Care Medicine, Department of Anesthesiology, University of Maryland Medical School, Baltimore, MD; Division of Trauma Anesthesiology, Program in Trauma, R Adams Cowley Shock Trauma Center, University of Maryland Medical School, Baltimore, MD. Electronic address: sgalvagno@anes.umm.edu.
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Galvagno
authors.forename: Caron M
authors.initials: CM
authors.lastname: Hong
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Lissauer
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Baker
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Murthi
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Herr
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Stein
mesh_terms: D000136:Acid-Base Equilibrium; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D007362:Intensive Care Units; D017582:Renal Replacement Therapy / Q000379:methods*; D014882:Water-Electrolyte Balance
keywords: Continuous renal replacement therapy; Dosing; Intensive care unit