title: Linking HSCs to their youth.
abstract: Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Pietras
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Passegué
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D025743:HMGA2 Protein / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D016601:RNA-Binding Proteins
chemical_list: D004268:DNA-Binding Proteins; D025743:HMGA2 Protein; C516326:LIN28B protein, human; D035683:MicroRNAs; D016601:RNA-Binding Proteins; C542687:mirnlet7 microRNA, mouse
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