title: Immunity to betanodavirus infections of marine fish.
abstract: Betanodaviruses cause viral nervous necrosis in numerous fish species, but some species are resistant to infection by these viruses. It is essential to fully characterize the immune responses that underlie this protective response. Complete characterization of the immune responses against nodaviruses may allow the development of methods that stimulate fish immunity and of an effective betanodavirus vaccine. Such strategies could include stimulation of specific immune system responses or blockage of factors that decrease the immune response. The innate immune system clearly provides a front-line defense, and this includes the production of interferons and other cytokines. Interferons that are released inside infected cells and that suppress viral replication may be the most ancient form of innate immunity. This review focuses on the immune responses of fish to betanodavirus infection.
authors.affiliation: Laboratory of Molecular Genetics, Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan; Translational Center for Marine Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan; Agriculture Biotechnology Research Center, National Cheng Kung University, Tainan 70101, Taiwan.
authors.forename: Young-Mao
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Laboratory of Molecular Genetics, Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan; Translational Center for Marine Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan.
authors.forename: Ting-Yu
authors.initials: TY
authors.lastname: Wang
authors.affiliation: Laboratory of Molecular Genetics, Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan; Translational Center for Marine Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan; Agriculture Biotechnology Research Center, National Cheng Kung University, Tainan 70101, Taiwan; University Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan; Research Center of Ocean Environment and Technology, National Cheng Kung University, Tainan 70101, Taiwan. Electronic address: ibcty@mail.ncku.edu.tw.
authors.forename: Tzong-Yueh
authors.initials: TY
authors.lastname: Chen
mesh_terms: D000818:Animals; D005393:Fish Diseases / Q000276:immunology*; D029941:Fish Proteins / Q000276:immunology*; D005399:Fishes / Q000276:immunology*; D007113:Immunity, Innate; D007372:Interferons / Q000276:immunology*; D030381:Nodaviridae / Q000276:immunology*; D012327:RNA Virus Infections / Q000276:immunology*
chemical_list: D029941:Fish Proteins; D007372:Interferons
keywords: Betanodavirus; Immunity; Marine fish