title: [Effect of anorexia and neuropathic pain induced by cisplatin on hindlimb muscles of rat].
abstract: OBJECTIVE
  The purpose of this study was to examine the effect of anorexia and neuropathic pain induced by cisplatin on hindlimb muscles of rats.
  
  
  METHODS
  Adult male Sprague-Dawley rats were divided into two groups, a cisplatin-treated group (n=10) and a control group (n=10). In the cisplatin-treated group, cisplatin at a dose of 2 mg/kg was injected intraperitoneally two times a week up to a cumulative dose of 20 mg/kg over 5 weeks, and in the control group saline (0.9% NaCl) was injected intraperitoneally at the same dose and duration as the cisplatin-treated group. At 34 days all rats were anesthetized, after which the soleus and plantaris muscles were dissected. Withdrawal threshold, body weight, food intake, activity, muscle weight, Type I and II fiber cross-sectional areas and myofibrillar protein content of the dissected muscles were determined.
  
  
  RESULTS
  Compared with the control group, the cisplatin-treated group showed significant decreases (p<.05) in withdrawal threshold, activity, food intake, body weight, Type I and II fiber cross-sectional areas, myofibrillar protein content and weight of the soleus and plantaris muscles.
  
  
  CONCLUSIONS
  Muscular atrophy in hindlimb occurs due to anorexia and neuropathic pain induced by the cisplatin treatment.
authors.affiliation: School of Nursing, University of Maryland, Baltimore, MD 21201, USA. gsyang@umaryland.edu
authors.forename: Gee Su
authors.initials: GS
authors.lastname: Yang
authors.forename: Myoung-Ae
authors.initials: MA
authors.lastname: Choe
mesh_terms: D000818:Animals; D000855:Anorexia; D001835:Body Weight; D002945:Cisplatin / Q000633:toxicity*; D004435:Eating; D006614:Hindlimb; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000473:pathology; D009124:Muscle Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology; D009437:Neuralgia / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009124:Muscle Proteins; D002945:Cisplatin
keywords: Anorexia; Cisplatin; Muscular atrophy; Neuropathic pain