title: Phoslactomycins from Streptomyces sp. MLA1839 and their biological activities.
abstract: Phoslactomycins H (1) and I (2), two new members of the phoslactomycin class of chemistry, were isolated from Streptomyces sp. MLA1839 on the basis of their antifungal activities. Their structures were elucidated using extensive NMR spectroscopy and mass spectrometry. Phoslactomycin H (1) featured a rare and unprecedented N,N-dimethylamine substitution at C-4 and existed as a hydroxy acid rather than the more common lactone. Herein, we report the structure of these compounds and their biological activities.
authors.affiliation: Discovery Research, Dow AgroSciences , 9330 Zionsville Road, Indianapolis, Indiana 46268, USA. SFotso@dow.com
authors.forename: Serge
authors.initials: S
authors.lastname: Fotso
authors.forename: Paul
authors.initials: P
authors.lastname: Graupner
authors.forename: Quanbo
authors.initials: Q
authors.lastname: Xiong
authors.forename: Don
authors.initials: D
authors.lastname: Hahn
authors.forename: Cruz
authors.initials: C
authors.lastname: Avila-Adame
authors.forename: George
authors.initials: G
authors.lastname: Davis
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D007783:Lactones; D009943:Organophosphorus Compounds; C584599:phoslactomycin H; C584600:phoslactomycin I