title: Health-related quality of life and survival in Chinese patients with chronic liver disease.
abstract: BACKGROUND
  To investigate the relationship between health-related quality of life (HRQOL) and survival in Chinese patients with chronic liver disease (CLD).
  
  
  METHODS
  HRQOL was measured with the Chinese version of Short Form 36 (SF-36). SF-36 scores, demographic and clinical data were collected at baseline and after 18 months follow-up. Kaplan-Meier and Cox Proportional Hazard Regression survival analyses were used for interpretation of data. Surviving patients were censored in the analyses.
  
  
  RESULTS
  A total of 415 Chinese patients with CLD and 86 healthy controls were enrolled. During the follow-up period 50 patients died. SF-36 scores in healthy controls and surviving patients were higher compared with those in deceased patients. Scores of physical component summary (PCS) in healthy controls, surviving and deceased patients were 54.1 ± 5.2, 48.9 ± 7.7 and 33.5 ± 8.2 respectively (p < 0.001). Scores of mental component summary (MCS) in healthy controls, surviving and deceased patients were 56.6 ± 8.2, 53.0 ± 5.6 and 37.1 ± 12.1 (p < 0.001) respectively. Survival was significantly associated with PCS and MCS scores, and the presence of ascites.
  
  
  CONCLUSIONS
  HRQOL was associated with survival in patients with CLD. PCS and MCS scores were predictors of survival.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Ru
authors.initials: R
authors.lastname: Gao
authors.forename: Guang
authors.initials: G
authors.lastname: Li
authors.forename: Zhan Min
authors.initials: ZM
authors.lastname: Shang
authors.forename: Jian Yu
authors.initials: JY
authors.lastname: Hao
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008103:Liver Cirrhosis / Q000401:mortality / Q000523:psychology; D008107:Liver Diseases / Q000401:mortality* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D016019:Survival Analysis
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