title: Promising molecular targets and biomarkers for male BPH and LUTS.
abstract: Benign prostatic hyperplasia (BPH) is a major health concern for aging men. BPH is associated with urinary voiding dysfunction and lower urinary tract symptoms (LUTS), which negatively affects quality of life. Surgical resection and medical approaches have proven effective for improving urinary flow and relieving LUTS but are not effective for all men and can produce adverse effects that require termination of the therapeutic regimen. Thus, there is a need to explore other therapeutic targets to treat BPH/LUTS. Complicating the treatment of BPH/LUTS is the lack of biomarkers to effectively identify pathobiologies contributing to BPH/LUTS or to gauge successful response to therapy. This review will briefly discuss current knowledge and will highlight new studies that illuminate the pathobiologies contributing to BPH/LUTS, potential new therapeutic strategies for successfully treating BPH/LUTS, and new approaches for better defining these pathobiologies and response to therapeutics through the development of biomarkers and phenotyping strategies.
authors.affiliation: Center for Personalized Cancer Therapy and the Department of Biology, The University of Massachusetts, Boston, Boston, MA, 02125, USA.
authors.forename: Mehrnaz
authors.initials: M
authors.lastname: Gharaee-Kermani
authors.forename: Jill A
authors.initials: JA
authors.lastname: Macoska
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000627:therapeutic use*; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000726:Androgen Antagonists / Q000627:therapeutic use*; D050034:Antidiuretic Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D005355:Fibrosis; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D058990:Molecular Targeted Therapy / Q000379:methods; D058628:Myofibroblasts / Q000502:physiology; D010936:Plant Extracts / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D058891:5-alpha Reductase Inhibitors; D058668:Adrenergic alpha-1 Receptor Antagonists; D000726:Androgen Antagonists; D050034:Antidiuretic Agents; D015415:Biomarkers; D010936:Plant Extracts; D003094:Collagen; D003894:Deamino Arginine Vasopressin
references.citation: Mol Endocrinol. 1988 Dec;2(12):1265-75
references.pmid: 3216866
references.citation: Int Urol Nephrol. 2012 Aug;44(4):1077-84
references.pmid: 22528586
references.citation: Eur Urol. 2005 Dec;48(6):1031-41
references.pmid: 16054748
references.citation: JAMA. 2011 Sep 28;306(12):1344-51
references.pmid: 21954478
references.citation: Sleep Med Rev. 2011 Apr;15(2):91-7
references.pmid: 20965130
references.citation: J Proteomics. 2012 Feb 2;75(4):1079-88
references.pmid: 22079244
references.citation: Neurourol Urodyn. 2002;21(2):179-83
references.pmid: 11857672
references.citation: Prostate Cancer Prostatic Dis. 2011 Dec;14(4):320-5
references.pmid: 21788967
references.citation: Urology. 2012 Jun;79(6):1385-8
references.pmid: 22482874
references.citation: Urology. 2008 Mar;71(3):475-9; discussion 479
references.pmid: 18342190
references.citation: Drug News Perspect. 2006 Mar;19(2):85-90
references.pmid: 16628263
references.citation: World J Gastroenterol. 2007 Jun 14;13(22):3056-62
references.pmid: 17589920
references.citation: BJU Int. 2013 Aug;112(4):432-41
references.pmid: 23650937
references.citation: Am J Pathol. 2000 Mar;156(3):813-9
references.pmid: 10702397
references.citation: J Clin Invest. 2004 Aug;114(3):438-46
references.pmid: 15286810
references.citation: Liver Int. 2006 Feb;26(1):8-22
references.pmid: 16420505
references.citation: J Cell Physiol. 2007 Jun;211(3):585-9
references.pmid: 17387717
references.citation: J Endocrinol. 1995 Nov;147(2):295-302
references.pmid: 7490559
references.citation: J Med Invest. 2013;60(1-2):127-37
references.pmid: 23614921
references.citation: World J Urol. 2010 Feb;28(1):9-15
references.pmid: 19956956
references.citation: Br J Urol. 1996 Sep;78(3):325-36
references.pmid: 8881937
references.citation: Cancer Res. 2006 Jan 15;66(2):794-802
references.pmid: 16424011
references.citation: J Urol. 2012 Oct;188(4):1375-81
references.pmid: 22906651
references.citation: Am J Respir Crit Care Med. 2005 Apr 15;171(8):889-98
references.pmid: 15563636
references.citation: Eur Respir Rev. 2013 Jun 1;22(128):163-8
references.pmid: 23728871
references.citation: Am J Pathol. 2003 Jun;162(6):1831-43
references.pmid: 12759241
references.citation: J Urol. 2008 May;179(5):1736-40
references.pmid: 18343414
references.citation: Endocrinology. 2007 Mar;148(3):1019-29
references.pmid: 17138653
references.citation: Curr Med Chem. 2009;16(11):1400-17
references.pmid: 19355895
references.citation: N Engl J Med. 2006 Feb 9;354(6):557-66
references.pmid: 16467543
references.citation: Adv Ther. 2012 Jun;29(6):538-50
references.pmid: 22644964
references.citation: Prostate. 2013 Jul;73(10):1123-33
references.pmid: 23532836
references.citation: Neurourol Urodyn. 2012 Apr;31(4):441-7
references.pmid: 22447415
references.citation: Int J Cancer. 2004 Nov 1;112(2):213-8
references.pmid: 15352032
references.citation: Prostate. 2010 Mar 1;70(4):377-89
references.pmid: 19866464
references.citation: J Biol Chem. 1997 Jul 11;272(28):17251-4
references.pmid: 9211859
references.citation: BJU Int. 2011 May;107(10):1550-4
references.pmid: 21518417
references.citation: Prostate. 2013 May;73(6):573-81
references.pmid: 23059958
references.citation: J Sex Med. 2010 Jan;7(1 Pt 1):234-43
references.pmid: 19732303
references.citation: J Sex Med. 2012 Jun;9(6):1624-33
references.pmid: 22510238
references.citation: J Immunol. 1998 Jul 15;161(2):547-51
references.pmid: 9670926
references.citation: Urology. 2006 Apr;67(4):713-8
references.pmid: 16566966
references.citation: J Pathol. 2008 Jan;214(2):199-210
references.pmid: 18161745
references.citation: Lab Invest. 2001 Sep;81(9):1309-18
references.pmid: 11555678
references.citation: BJU Int. 2012 Jun;109(12):1831-40
references.pmid: 21966995
references.citation: N Engl J Med. 1994 Nov 10;331(19):1286-92
references.pmid: 7935686
references.citation: Pharm Res. 2007 May;24(5):819-41
references.pmid: 17333393
references.citation: Urology. 1999 Jul;54(1):86-9
references.pmid: 10414732
references.citation: Mol Cell Biochem. 2003 Nov;253(1-2):89-101
references.pmid: 14619959
references.citation: Mini Rev Med Chem. 2006 Nov;6(11):1255-61
references.pmid: 17100637
references.citation: J Am Soc Nephrol. 2013 Sep;24(9):1387-98
references.pmid: 23723426
references.citation: J Urol. 2000 Sep;164(3 Pt 1):876-81
references.pmid: 10953171
references.citation: J Sex Med. 2010 Jan;7(1 Pt 1):59-69
references.pmid: 19796053
references.citation: Expert Opin Investig Drugs. 2008 Jun;17(6):905-16
references.pmid: 18491991
references.citation: Clin Ther. 2007 Mar;29(3):387-98
references.pmid: 17577460
references.citation: BJU Int. 2012 Jun;109(12):1756-61
references.pmid: 22551330
references.citation: Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2950-4
references.pmid: 1557400
references.citation: Eur Urol. 2007 Jul;52(1):221-9
references.pmid: 17280773
references.citation: J Urol. 2005 Oct;174(4 Pt 1):1334-8
references.pmid: 16145414
references.citation: BJU Int. 2005 Jun;95 Suppl 4:29-36
references.pmid: 15871733
references.citation: Eur Urol. 2007 Jun;51(6):1522-33
references.pmid: 17416456
references.citation: Prostate. 2009 Dec 1;69(16):1774-80
references.pmid: 19670242
references.citation: J Clin Invest. 2005 Feb;115(2):209-18
references.pmid: 15690074
references.citation: Int J Antimicrob Agents. 2008 Feb;31 Suppl 1:S85-90
references.pmid: 18164907
references.citation: Expert Opin Emerg Drugs. 2007 Nov;12(4):627-46
references.pmid: 17979604
references.citation: Urology. 2006 Aug;68(2):352-6
references.pmid: 16904451
references.citation: Rev Urol. 2009 Fall;11(Suppl 1):S19-25
references.pmid: 20126608
references.citation: J Urol. 2002 Jun;167(6):2484-7; discussion 2487-8
references.pmid: 11992063
references.citation: JAMA. 2006 Nov 15;296(19):2319-28
references.pmid: 17105794
references.citation: Steroids. 1994 Nov;59(11):616-20
references.pmid: 7535480
references.citation: Med Care. 1995 Apr;33(4 Suppl):AS145-55
references.pmid: 7536866
references.citation: Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L562-74
references.pmid: 10956632
references.citation: PLoS One. 2012;7(11):e49278
references.pmid: 23173053
references.citation: J Urol. 1992 Nov;148(5):1549-57; discussion 1564
references.pmid: 1279218
references.citation: Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):389-402
references.pmid: 18471794
references.citation: Eur Urol. 1996;29(3):345-54
references.pmid: 8740022
references.citation: Urology. 2006 Jun;67(6):1188-92
references.pmid: 16750254
references.citation: Br J Nutr. 2007 Dec;98(6):1237-42
references.pmid: 17640419
references.citation: Eur Urol. 2003 Nov;44(5):549-55
references.pmid: 14572753
references.citation: Lancet. 1993 Nov 13;342(8881):1209-10
references.pmid: 7901532
references.citation: J Exp Med. 2011 Jul 4;208(7):1339-50
references.pmid: 21727191
references.citation: Acta Oncol. 1991;30(2):133-40
references.pmid: 2029395
references.citation: Nat Rev Cancer. 2008 Apr;8(4):268-78
references.pmid: 18337732
references.citation: Eur Urol. 1998;34 Suppl 2:37-45
references.pmid: 9732827
references.citation: Arthritis Rheum. 2005 Mar;52(3):710-21
references.pmid: 15751074
references.citation: J Nat Med. 2012 Jul;66(3):476-85
references.pmid: 22101440
references.citation: Urology. 1999 Mar;53(3):581-9
references.pmid: 10096388
references.citation: Nature. 2012 Nov 15;491(7424):384-92
references.pmid: 23151581
references.citation: Eur Urol. 2012 May;61(5):994-1003
references.pmid: 22405510
references.citation: Eur Urol. 2007 Feb;51(2):524-33; discussion 533
references.pmid: 16905241
references.citation: Eur Urol. 2007 May;51(5):1202-16
references.pmid: 17182170
references.citation: Lancet Neurol. 2004 Jan;3(1):46-53
references.pmid: 14693111
references.citation: Curr Opin Investig Drugs. 2006 Jun;7(6):513-21
references.pmid: 16784021
references.citation: Nat Med. 2012 Jul 06;18(7):1028-40
references.pmid: 22772564
references.citation: J Urol. 2004 Sep;172(3):1021-5
references.pmid: 15311028
references.citation: Front Biosci. 2003 Sep 01;8:s740-9
references.pmid: 12957826
references.citation: BJU Int. 2002 Jun;89(9):855-62
references.pmid: 12010228
references.citation: Biochim Biophys Acta. 2009 Aug;1792(8):746-56
references.pmid: 19539753