title: Rise of the selective inhibitors of anti-apoptotic Bcl-2 family proteins.
abstract: No trivial pursuit! It is not trivial to develop effective small-molecule regulators of protein-protein interactions (PPIs). Moreover, anti-apoptotic Bcl-2 family proteins share similar binding grooves, making it particularly difficult to target them selectively. Despite these challenges, potent and selective inhibitors of individual members of the Bcl-2 family have been successfully developed.
authors.affiliation: State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Renxiao
authors.initials: R
authors.lastname: Wang
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D057166:High-Throughput Screening Assays; D008969:Molecular Sequence Data; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016415:Sequence Alignment; D054852:Small Molecule Libraries / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry / Q000378:metabolism
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D054852:Small Molecule Libraries; D013449:Sulfonamides
keywords: Bcl-2 family proteins; apoptosis inducers; protein-protein interactions; small-molecule regulators