title: Design of a nitrogen-implanted titanium-based superelastic alloy with optimized properties for biomedical applications.
abstract: In this study, a superelastic Ni-free Ti-based biomedical alloy was treated in surface by the implantation of nitrogen ions for the first time. The N-implanted surface was characterized by X-ray diffraction, X-ray photoelectron spectroscopy, and secondary ion mass spectroscopy, and the superficial mechanical properties were evaluated by nano-indentation and by ball-on-disk tribological tests. To investigate the biocompatibility, the corrosion resistance of the N-implanted Ti alloy was evaluated in simulated body fluids (SBF) complemented by in-vitro cytocompatibility tests on human fetal osteoblasts. After implantation, surface analysis methods revealed the formation of a titanium-based nitride on the substrate surface. Consequently, an increase in superficial hardness and a significant reduction of friction coefficient were observed compared to the non-implanted sample. Also, a better corrosion resistance and a significant decrease in ion release rates have been obtained. Cell culture experiments indicated that the cytocompatibility of the N-implanted Ti alloy was superior to that of the corresponding non-treated sample. Thus, this new functional N-implanted titanium-based superelastic alloy presents the optimized properties that are required for various medical devices: superelasticity, high superficial mechanical properties, high corrosion resistance and excellent cytocompatibility.
authors.affiliation: INSA de Rennes, Laboratoire Chimie-Métallurgie, UMR CNRS 6226 Institut des Sciences Chimiques de Rennes, 20 avenue des Buttes de Coësmes, 35708 Rennes Cedex 7, France.
authors.forename: D M
authors.initials: DM
authors.lastname: Gordin
authors.forename: D
authors.initials: D
authors.lastname: Busardo
authors.forename: A
authors.initials: A
authors.lastname: Cimpean
authors.forename: C
authors.initials: C
authors.lastname: Vasilescu
authors.forename: D
authors.initials: D
authors.lastname: Höche
authors.forename: S I
authors.initials: SI
authors.lastname: Drob
authors.forename: V
authors.initials: V
authors.lastname: Mitran
authors.forename: M
authors.initials: M
authors.lastname: Cornen
authors.forename: T
authors.initials: T
authors.lastname: Gloriant
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D020811:Biomedical Technology / Q000379:methods*; D001826:Body Fluids / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003343:Corrosion; D004548:Elasticity; D005333:Fetus / Q000166:cytology; D005353:Fibronectins / Q000096:biosynthesis; D017276:Friction; D006244:Hardness; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009584:Nitrogen / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D056951:Photoelectron Spectroscopy; D011199:Potentiometry; D013314:Stress, Mechanical; D013499:Surface Properties; D013718:Tensile Strength / Q000187:drug effects; D014025:Titanium / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D005353:Fibronectins; D014025:Titanium; D007770:L-Lactate Dehydrogenase; D009584:Nitrogen
keywords: Biocompatibility; Corrosion resistance; Ion implantation; Surface analysis; Titanium alloy