title: CO₂-based in-line phase contrast imaging of small intestine in mice.
abstract: The objective of this study was to explore the potential of CO₂ single contrast in-line phase contrast imaging (PCI) for pre-clinical small intestine investigation. The absorption and phase contrast images of CO₂ gas production were attained and compared. A further increase in image contrast was observed in PCI. Compared with CO₂-based absorption contrast imaging (ACI), CO₂-based PCI significantly enhanced the detection of mucosal microstructures, such as pits and folds. The CO₂-based PCI could provide sufficient image contrast for clearly showing the intestinal mucosa in living mice without using barium. We concluded that CO₂-based PCI might be a novel and promising imaging method for future studies of gastrointestinal disorders.
authors.affiliation: Department of Radiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PRC. tangme8688258@sina.com
authors.forename: Rongbiao
authors.initials: R
authors.lastname: Tang
authors.forename: Wei-Xia
authors.initials: WX
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Fuhua
authors.initials: F
authors.lastname: Yan
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Chai
authors.forename: Guo-Yuan
authors.initials: GY
authors.lastname: Yang
authors.forename: Ke-Min
authors.initials: KM
authors.lastname: Chen
mesh_terms: D000818:Animals; D002245:Carbon Dioxide; D003287:Contrast Media; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology; D007421:Intestine, Small / Q000000981:diagnostic imaging*; D051379:Mice; D008858:Microscopy, Phase-Contrast; D008875:Middle Aged; D011859:Radiography
chemical_list: D003287:Contrast Media; D002245:Carbon Dioxide
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