title: Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease.
abstract: The important role of monocytes and macrophages in diseases like cancer and atherosclerosis has started to get uncovered in the last decade. In addition, subsets of these cell types are believed to participate in the initiation and aggravation of several diseases including cancer and cardiovascular disease. For this reason, monocytes and macrophages have recently been identified as interesting targets for both diagnosis and treatment of the aforementioned pathologies. Compared with free therapeutic or imaging agents, nanoparticle formulations provide several advantages that improve the pharmacokinetics and bioavailability of these agents. In addition, the possibility of surface functionalization creates numerous ways to optimize nanoparticle delivery. Recent advances in nanomedicine have led to the development of multifunctional nanoparticles that allow simultaneous diagnosis and treatment of monocytes and macrophages with high specificity. Relying on the inherent ability of monocytes and macrophages to easily take up foreign particles, the use of nanoparticles provides a precious opportunity for the management of several inflammatory diseases.
authors.affiliation: Department of Cell Biology and immunology, VU University Medical Center, van der Boechorsstraat 7, 1081 BT Amsterdam, The Netherlands.
authors.forename: Marnix A
authors.initials: MA
authors.lastname: Lameijer
authors.forename: Jun
authors.initials: J
authors.lastname: Tang
authors.forename: Matthias
authors.initials: M
authors.lastname: Nahrendorf
authors.forename: Robert H J
authors.initials: RH
authors.lastname: Beelen
authors.forename: Willem J M
authors.initials: WJ
authors.lastname: Mulder
mesh_terms: D050197:Atherosclerosis / Q000175:diagnosis / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000188:drug therapy; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000378:metabolism*; D009000:Monocytes / Q000166:cytology / Q000378:metabolism*; D050997:Nanomedicine; D053758:Nanoparticles; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D057089:Pathology, Molecular
references.citation: Immunity. 2013 Jan 24;38(1):79-91
references.pmid: 23273845
references.citation: J Magn Reson Imaging. 2005 Apr;21(4):432-42
references.pmid: 15779033
references.citation: Annu Rev Biomed Eng. 2012;14:1-16
references.pmid: 22524388
references.citation: J Pathol. 2008 Jan;214(2):161-78
references.pmid: 18161744
references.citation: J Control Release. 2002 Feb 19;79(1-3):29-40
references.pmid: 11853916
references.citation: Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):1-18
references.pmid: 19782542
references.citation: Arthritis Rheum. 2011 Sep;63(9):2671-80
references.pmid: 21618461
references.citation: Atherosclerosis. 2007 Aug;193(2):245-58
references.pmid: 16996518
references.citation: Nat Med. 2011 Nov 07;17(11):1410-22
references.pmid: 22064431
references.citation: Nat Rev Drug Discov. 2011 Oct 21;10(11):835-52
references.pmid: 22015921
references.citation: Nat Rev Immunol. 2010 Jun;10(6):453-60
references.pmid: 20467425
references.citation: Small. 2010 Sep 20;6(18):2041-9
references.pmid: 20721949
references.citation: Clin Cancer Res. 2011 Sep 1;17(17):5695-704
references.pmid: 21791632
references.citation: Nat Immunol. 2006 Mar;7(3):311-7
references.pmid: 16462739
references.citation: Lancet. 1966 Jun 4;1(7449):1225-8
references.pmid: 4161205
references.citation: J Clin Invest. 2011 Jan;121(1):442-5
references.pmid: 21123946
references.citation: Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10340-10345
references.pmid: 16801531
references.citation: Nat Rev Immunol. 2011 Oct 10;11(11):762-74
references.pmid: 21984070
references.citation: ACS Nano. 2011 Apr 26;5(4):2493-502
references.pmid: 21391720
references.citation: Circ Res. 2010 Sep 17;107(6):737-46
references.pmid: 20651288
references.citation: Cell. 2010 Apr 2;141(1):39-51
references.pmid: 20371344
references.citation: Nat Rev Immunol. 2008 Oct;8(10):802-15
references.pmid: 18825131
references.citation: Circulation. 2008 Jan 22;117(3):379-87
references.pmid: 18158358
references.citation: Neurosurgery. 2007 Mar;60(3):524-9; discussion 529-30
references.pmid: 17327798
references.citation: J Clin Invest. 2007 Jan;117(1):175-84
references.pmid: 17200717
references.citation: Hematology Am Soc Hematol Educ Program. 2009;:708-19
references.pmid: 20008257
references.citation: J Exp Med. 2007 Nov 26;204(12):3037-47
references.pmid: 18025128
references.citation: Proc Am Thorac Soc. 2005;2(5):403-11
references.pmid: 16322590
references.citation: Mol Ther. 2009 Jan;17(1):162-8
references.pmid: 18827803
references.citation: Oncoimmunology. 2012 Sep 1;1(6):798-809
references.pmid: 23162747
references.citation: Drug Dev Ind Pharm. 2006 Jan;32(1):125-35
references.pmid: 16455611
references.citation: Annu Rev Immunol. 2009;27:165-97
references.pmid: 19302038
references.citation: Acta Pharm. 2008 Mar;58(1):61-74
references.pmid: 18337208
references.citation: Curr Cancer Drug Targets. 2006 Mar;6(2):123-33
references.pmid: 16529542
references.citation: Endocr Rev. 2011 Feb;32(1):31-63
references.pmid: 20851921
references.citation: Immunobiology. 2006;211(6-8):609-18
references.pmid: 16920499
references.citation: Liver Int. 2006 Dec;26(10):1175-86
references.pmid: 17105582
references.citation: Immunity. 2003 Jul;19(1):71-82
references.pmid: 12871640
references.citation: Exp Mol Pathol. 2009 Jun;86(3):215-23
references.pmid: 19186176
references.citation: Arthritis Res Ther. 2007;9(6):224
references.pmid: 18177511
references.citation: Clin Pharmacol Ther. 2008 May;83(5):761-9
references.pmid: 17957183
references.citation: Immunobiology. 2011 Jul;216(7):753-62
references.pmid: 21281986
references.citation: Mol Pharm. 2013 Mar 4;10(3):831-47
references.pmid: 23360440
references.citation: J Exp Med. 2005 Jun 6;201(11):1761-9
references.pmid: 15928200
references.citation: N Engl J Med. 2005 Oct 20;353(16):1711-23
references.pmid: 16236742
references.citation: Semin Liver Dis. 2010 Aug;30(3):245-57
references.pmid: 20665377
references.citation: Science. 2011 Jun 10;332(6035):1268-9
references.pmid: 21659591
references.citation: NMR Biomed. 2013 Jul;26(7):766-80
references.pmid: 23303729
references.citation: J Leukoc Biol. 2006 Nov;80(5):1165-74
references.pmid: 16908517
references.citation: Nat Immunol. 2012 Feb 26;13(4):361-8
references.pmid: 22366893
references.citation: Cancer Res. 2012 Aug 15;72(16):4165-77
references.pmid: 22719068
references.citation: J Exp Med. 2009 Aug 31;206(9):1883-97
references.pmid: 19652016
references.citation: Curr Cardiovasc Imaging Rep. 2012 Feb;5(1):19-25
references.pmid: 22308199
references.citation: Nano Lett. 2007 Dec;7(12):3759-65
references.pmid: 17979310
references.citation: Thromb Haemost. 2004 Aug;92(2):419-24
references.pmid: 15269840
references.citation: Int J Pharm. 2004 Jan 9;269(1):37-49
references.pmid: 14698575
references.citation: Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2491-6
references.pmid: 22308361
references.citation: Nat Rev Immunol. 2011 Oct 14;11(11):723-37
references.pmid: 21997792
references.citation: Chem Soc Rev. 2012 Apr 7;41(7):2539-44
references.pmid: 22310807
references.citation: Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):750-7
references.pmid: 21252070
references.citation: Nat Biotechnol. 2005 Nov;23(11):1418-23
references.pmid: 16244656
references.citation: Mol Pharm. 2010 Dec 6;7(6):2020-9
references.pmid: 21028895
references.citation: Med Oncol. 2011 Dec;28(4):1447-52
references.pmid: 20676804
references.citation: Trends Immunol. 2002 Nov;23(11):549-55
references.pmid: 12401408
references.citation: Immunity. 2012 Dec 14;37(6):1076-90
references.pmid: 23219392
references.citation: Blood. 1989 Nov 15;74(7):2527-34
references.pmid: 2478233
references.citation: Annu Rev Med. 2012;63:185-98
references.pmid: 21888516
references.citation: Pharmacol Res. 2010 Aug;62(2):90-9
references.pmid: 20380880
references.citation: Expert Rev Mol Med. 2009 May 14;11:e14
references.pmid: 19439108
references.citation: Nature. 2008 Jul 24;454(7203):436-44
references.pmid: 18650914
references.citation: Cell. 2011 Apr 29;145(3):341-55
references.pmid: 21529710
references.citation: Mol Pharmacol. 2008 Nov;74(5):1183-92
references.pmid: 18669445
references.citation: Nat Rev Drug Discov. 2010 Aug;9(8):615-27
references.pmid: 20616808
references.citation: Nat Rev Immunol. 2005 Aug;5(8):606-16
references.pmid: 16056254
references.citation: J Cereb Blood Flow Metab. 2010 Jan;30(1):15-35
references.pmid: 19756021
references.citation: Am J Pathol. 1995 Sep;147(3):668-77
references.pmid: 7677178
references.citation: Acc Chem Res. 2008 Dec;41(12):1842-51
references.pmid: 19053240
references.citation: Nanomedicine. 2011 Feb;7(1):88-96
references.pmid: 20887813
references.citation: J Immunol. 2005 Jul 1;175(1):342-9
references.pmid: 15972667
references.citation: Adv Drug Deliv Rev. 2010 Aug 30;62(11):1005-22
references.pmid: 20851156
references.citation: Rheumatology (Oxford). 2013 Apr;52(4):590-8
references.pmid: 23204551
references.citation: Cancer Res. 1980 Dec;40(12):4460-6
references.pmid: 7002293
references.citation: Bioconjug Chem. 2011 Dec 21;22(12):2383-9
references.pmid: 22035047
references.citation: Nature. 2011 May 19;473(7347):317-25
references.pmid: 21593864
references.citation: Sci Transl Med. 2012 Apr 4;4(128):128ra39
references.pmid: 22491949
references.citation: Cell. 2013 Apr 11;153(2):362-75
references.pmid: 23582326
references.citation: Arterioscler Thromb Vasc Biol. 2006 May;26(5):987-94
references.pmid: 16497993
references.citation: Curr Opin Hematol. 2010 Jan;17(1):53-9
references.pmid: 19770654
references.citation: J Clin Invest. 2007 Jan;117(1):185-94
references.pmid: 17200718
references.citation: Nat Rev Clin Oncol. 2010 Nov;7(11):653-64
references.pmid: 20838415
references.citation: Curr Opin Rheumatol. 2007 May;19(3):289-95
references.pmid: 17414958
references.citation: Nano Lett. 2008 Nov;8(11):3715-23
references.pmid: 18939808
references.citation: Methods Enzymol. 2012;508:211-28
references.pmid: 22449928
references.citation: Nat Biotechnol. 2011 Oct 09;29(11):1005-10
references.pmid: 21983520
references.citation: FASEB J. 2005 Mar;19(3):311-30
references.pmid: 15746175
references.citation: Science. 2009 Jul 31;325(5940):612-6
references.pmid: 19644120
references.citation: Science. 2013 Jan 11;339(6116):161-6
references.pmid: 23307733
references.citation: Annu Rev Pathol. 2012;7:353-84
references.pmid: 22054143
references.citation: Nat Immunol. 2010 Oct;11(10):889-96
references.pmid: 20856220
references.citation: J Drug Deliv. 2011;2011:727241
references.pmid: 21512579
references.citation: Neoplasia. 2009 May;11(5):459-68, 2 p following 468
references.pmid: 19412430
references.citation: COPD. 2004 Apr;1(1):59-70
references.pmid: 16997739
references.citation: J Control Release. 2010 Sep 1;146(2):182-95
references.pmid: 20359513
references.citation: Blood. 1995 May 15;85(10):2910-7
references.pmid: 7742551
references.citation: J Nucl Med. 2013 May;54(5):807-14
references.pmid: 23447654
references.citation: J Immunol. 2008 Nov 1;181(9):5829-35
references.pmid: 18941170
references.citation: Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1412-8
references.pmid: 19759373
references.citation: Pharm Res. 2007 Jan;24(1):1-16
references.pmid: 17109211
references.citation: Clin Exp Immunol. 2005 Dec;142(3):481-9
references.pmid: 16297160
references.citation: J Exp Med. 2008 Jun 9;205(6):1261-8
references.pmid: 18490490
references.citation: Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):992-1000
references.pmid: 19057023
references.citation: Diabetes. 2005 Dec;54 Suppl 2:S97-107
references.pmid: 16306347
references.citation: Cancer Lett. 2008 Aug 28;267(2):271-85
references.pmid: 18439751
references.citation: Nat Rev Drug Discov. 2005 Feb;4(2):145-60
references.pmid: 15688077