title: Lung cancer during pregnancy: an unusual case.
abstract: The incidence of pregnancy-associated cancer is relatively low, complicating only 0.02-0.1% of all pregnancies. The authors describe a case of a 36-year-old woman, a light smoker, who was admitted to the hospital at 27 weeks of pregnancy, with respiratory symptoms since second trimester. Chest-X ray showed total left lung opacity with contralateral mediastinal deviation, suggestive of pleural effusion, and the pleural biopsy revealed invasion by lung adenocarcinoma. EGFR mutation test was negative. After a multidisciplinary meeting, it was decided to start fetal lung maturation and cesarean section at 29 weeks gestation. The patient received two lines of chemotherapy and bone metastasis radiotherapy, but there was progression of the disease. An EML4-ALK translocation was identified in an additional genetic test. Crizotinib 250mg BID was started. The patient showed a progression-free survival of 9 months and died 19 months after lung adenocarcinoma was diagnosed.
authors.affiliation: Serviço de Pneumologia, Centro Hospitalar de São João, EPE - Porto, Porto, Portugal. Electronic address: inesneves.porto@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Neves
authors.affiliation: Serviço de Pneumologia, Centro Hospitalar de São João, EPE - Porto, Porto, Portugal; Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
authors.forename: P C
authors.initials: PC
authors.lastname: Mota
authors.affiliation: Serviço de Pneumologia, Centro Hospitalar de São João, EPE - Porto, Porto, Portugal; Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
authors.forename: V P
authors.initials: VP
authors.lastname: Hespanhol
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000628:therapy; D000077192:Adenocarcinoma of Lung; D000328:Adult; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000628:therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000628:therapy
keywords: Cancro do pulmão; Crizotinib; EML4-AKL; Gravidez; Lung cancer; Pregnancy; Tratamento; Treatment