title: Tandem modifications of an epoxyquinone C7N pharmacophore.
abstract: C7N moieties are wildly present as pharmacophores in natural products. In this issue of Chemistry & Biology, Rui and colleagues biochemically reproduced the initiation event of asukamycin biosynthesis and characterized tandem enzymatic oxygenations of the epoxyquinone C7N moiety.
authors.affiliation: State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China. bailq@sjtu.edu.cn
authors.forename: Linquan
authors.initials: L
authors.lastname: Bai
mesh_terms: D016227:Benzoquinones / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D011090:Polyenes / Q000378:metabolism*; D053284:Polyunsaturated Alkamides / Q000378:metabolism*
chemical_list: D016227:Benzoquinones; D011090:Polyenes; D053284:Polyunsaturated Alkamides; C004532:quinone; D010088:Oxidoreductases; C054474:manumycin; D010100:Oxygen