title: Brief communication: Effect of nomadic subsistence practices on lactase persistence associated genetic variation in Kuwait.
abstract: Lactase persistence (LP)-the ability to digest lactose in adulthood-is paradigmatic of Holocenic dietary change affecting the evolutionary trajectory of specific populations. Kuwait represents one location of high LP where the variation in associated genomic regions has not been examined. Here, we present new sequence data from a 427 bp amplicon 14 kb upstream of the LCT (lactase) gene for two Bedouin tribal populations, the Ajman and Mutran. We estimate the frequency of known LP associated alleles and discuss the impact of nomadic-pastoralism on the associated genetic variation. We observe high frequency (56% on average) of the -13,915*G allele in both tribes, which is consistent with the high prevalence of LP in Kuwait. Whilst LP associated alleles occur in Kuwait at a similar frequency to other regional populations, we suggest that the -13,915*G allele frequency among the Kuwaiti Bedouin may be higher than among non-Bedouin Kuwaitis, possibly due to greater historical reliance on milk consumption or genetic drift.
authors.affiliation: Leverhulme Center for Human Evolutionary Studies, University of Cambridge, Cambridge, CB2 1QH, UK.
authors.forename: Sarah Catherine
authors.initials: SC
authors.lastname: Hill
authors.forename: Talal Ramadan
authors.initials: TR
authors.lastname: Mohammad
authors.forename: Toomas
authors.initials: T
authors.lastname: Kivisild
mesh_terms: D018912:Arabs / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D007730:Kuwait / Q000453:epidemiology; D043322:Lactase / Q000235:genetics*; D007787:Lactose Intolerance / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D020641:Polymorphism, Single Nucleotide
chemical_list: D043322:Lactase
keywords: Bedouin; genetics; lactose tolerance; nomadic-pastoralism