title: Stimulus-specific adaptation in auditory thalamus of young and aged awake rats.
abstract: Novel stimulus detection by single neurons in the auditory system, known as stimulus-specific adaptation (SSA), appears to function as a real-time filtering/gating mechanism in processing acoustic information. Particular stimulus paradigms allowing for quantification of a neuron's ability to detect novel or deviant stimuli have been used to examine SSA in the inferior colliculus, medial geniculate body (MGB), and auditory cortex of anesthetized rodents. However, the study of SSA in awake animals is limited to auditory cortex. The present study used individually advanceable tetrodes to record single-unit responses from auditory thalamus (MGB) of awake young adult and aged Fischer Brown Norway (FBN) rats to 1) examine the presence of SSA in the MGB of awake rats and 2) determine whether SSA is altered by aging in MGB. MGB single units in awake FBN rats displayed SSA in response to two stimulus paradigms: the oddball paradigm and a random blocked/interleaved presentation of a set of frequencies. SSA levels were modestly, but nonsignificantly, increased in the nonlemniscal regions of the MGB and at lower stimulus intensities, where 27 of 57 (47%) young adult MGB units displayed SSA. The present findings provide the initial description of SSA in the MGB of awake rats and support SSA as being qualitatively independent of arousal level or anesthetized state. Finally, contrary to previous studies in auditory cortex of anesthetized rats, MGB units in aged rats showed SSA levels indistinguishable from SSA levels in young adult rats, suggesting that SSA in MGB was not impacted by aging in an awake preparation.
authors.affiliation: Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois;
authors.forename: Ben D
authors.initials: BD
authors.lastname: Richardson
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Hancock
authors.forename: Donald M
authors.initials: DM
authors.lastname: Caspary
mesh_terms: D000161:Acoustic Stimulation; D000222:Adaptation, Physiological; D000367:Age Factors; D000758:Anesthesia; D000818:Animals; D005072:Evoked Potentials, Auditory; D005829:Geniculate Bodies / Q000502:physiology*; D008959:Models, Neurological; D051381:Rats; D014851:Wakefulness
keywords: aging; auditory thalamus; awake animals; medial geniculate body; stimulus-specific adaptation
references.citation: J Neurosci. 2004 Nov 17;24(46):10440-53
references.pmid: 15548659
references.citation: J Physiol. 2014 Feb 15;592(4):729-43
references.pmid: 24099802
references.citation: J Neurosci. 2009 Jun 3;29(22):7359-63
references.pmid: 19494157
references.citation: J Neurophysiol. 2009 Sep;102(3):1483-90
references.pmid: 19571199
references.citation: J Neurosci. 2007 Jun 6;27(23):6091-102
references.pmid: 17553982
references.citation: Clin Neurophysiol. 2002 Mar;113(3):396-406
references.pmid: 11897540
references.citation: J Neurosci. 2010 Dec 8;30(49):16475-84
references.pmid: 21147987
references.citation: Hear Res. 2010 Jun 1;264(1-2):79-85
references.pmid: 19772906
references.citation: J Neurosci. 2013 Jan 16;33(3):1218-27a
references.pmid: 23325258
references.citation: Anesth Analg. 2002 Feb;94(2):313-8, table of contents
references.pmid: 11812690
references.citation: J Neurosci. 2012 Dec 5;32(49):17762-74
references.pmid: 23223296
references.citation: Neuroscience. 2011 May 5;181:163-74
references.pmid: 21284952
references.citation: J Neurosci. 2009 Apr 29;29(17):5483-93
references.pmid: 19403816
references.citation: Hear Res. 2010 Jun 1;264(1-2):21-9
references.pmid: 19800958
references.citation: J Neurophysiol. 1994 Sep;72(3):1270-7
references.pmid: 7807210
references.citation: Psychophysiology. 2011 Mar;48(3):377-84
references.pmid: 20636288
references.citation: Brain Res. 2010 Sep 10;1351:115-129
references.pmid: 20615398
references.citation: J Speech Lang Hear Res. 2007 Aug;50(4):857-64
references.pmid: 17675591
references.citation: J Neurosci. 1983 Nov;3(11):2365-80
references.pmid: 6313877
references.citation: Br J Audiol. 2001 Jun;35(3):173-82
references.pmid: 11548044
references.citation: PLoS One. 2012;7(3):e34297
references.pmid: 22479591
references.citation: J Speech Hear Res. 1995 Jun;38(3):706-13
references.pmid: 7674661
references.citation: J Neurophysiol. 1968 Jan;31(1):44-61
references.pmid: 5640739
references.citation: Front Neural Circuits. 2013 Jan 14;6:119
references.pmid: 23335885
references.citation: J Neurosci. 2009 Nov 4;29(44):13837-49
references.pmid: 19889995
references.citation: J Neurosci. 2010 Nov 3;30(44):14795-804
references.pmid: 21048138
references.citation: Neuroscience. 2005;132(4):1103-13
references.pmid: 15857714
references.citation: Neuroscience. 2008 Jun 23;154(2):784-95
references.pmid: 18485606
references.citation: J Speech Hear Res. 1995 Oct;38(5):1150-6
references.pmid: 8558883
references.citation: Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13900-5
references.pmid: 20643928
references.citation: Proc Natl Acad Sci U S A. 1984 Jul;81(14):4586-90
references.pmid: 6589612
references.citation: PLoS One. 2010 Nov 19;5(11):e14071
references.pmid: 21124913
references.citation: Zh Vyssh Nerv Deiat Im I P Pavlova. 1977 Sep-Oct;27(5):1075-82
references.pmid: 930404
references.citation: J Neurophysiol. 1951 Sep;14(5):409-22
references.pmid: 14861675
references.citation: Trends Neurosci. 1998 Jan;21(1):28-32
references.pmid: 9464683
references.citation: Psychol Aging. 1999 Sep;14(3):507-19
references.pmid: 10509703
references.citation: J Neurosci. 2011 Nov 23;31(47):17306-16
references.pmid: 22114297
references.citation: Neurosci Biobehav Rev. 2011 Nov;35(10):2046-57
references.pmid: 21645541
references.citation: Nat Neurosci. 2003 Apr;6(4):391-8
references.pmid: 12652303
references.citation: Front Neural Circuits. 2013 Jan 17;6:89
references.pmid: 23335883
references.citation: Neuroscience. 2009 Apr 21;160(1):227-39
references.pmid: 19217931
references.citation: Front Neural Circuits. 2012 Dec 27;6:107
references.pmid: 23293586
references.citation: Neuroscience. 2008 Oct 15;156(3):748-57
references.pmid: 18775477
references.citation: Eur J Neurosci. 2010 Sep;32(5):859-65
references.pmid: 20626459
references.citation: Clin Neurophysiol. 2007 Dec;118(12):2544-90
references.pmid: 17931964
references.citation: Eur J Neurosci. 2013 Jan;37(1):52-62
references.pmid: 23121128
references.citation: J Neurosci. 2012 Jan 25;32(4):1447-52
references.pmid: 22279229
references.citation: J Neurosci. 2011 Jun 29;31(26):9708-22
references.pmid: 21715636
references.citation: J Comp Neurol. 2012 May 1;520(7):1457-80
references.pmid: 22101990
references.citation: Brain Res Brain Res Rev. 2004 Aug;46(1):1-31
references.pmid: 15297152
references.citation: Cereb Cortex. 2009 Sep;19(9):1957-67
references.pmid: 19037080
references.citation: Nat Neurosci. 2009 Sep;12(9):1165-70
references.pmid: 19684591
references.citation: J Neurosci. 2006 Apr 19;26(16):4444-50
references.pmid: 16624964
references.citation: J Exp Biol. 2008 Jun;211(Pt 11):1781-91
references.pmid: 18490394
references.citation: Eur J Neurosci. 2005 Dec;22(11):2879-85
references.pmid: 16324123
references.citation: J Neurosci. 2005 Nov 23;25(47):10952-9
references.pmid: 16306408
references.citation: Neurobiol Aging. 1998 Sep-Oct;19(5):447-59
references.pmid: 9880047
references.citation: J Assoc Res Otolaryngol. 2005 Sep;6(3):207-22
references.pmid: 16027962