title: Use of a KIT-specific monoclonal antibody to bypass imatinib resistance in gastrointestinal stromal tumors.
abstract: Acquired resistance to imatinib is a significant problem for the clinical management of gastrointestinal stromal tumor (GIST) patients, and second-line small molecules have shown limited efficacy in this setting. We have recently demonstrated that a monoclonal antibody targeting KIT could potentially bypass imatinib resistance in preclinical models of GIST.
authors.affiliation: Department of Pathology; Stanford University School of Medicine; Stanford, CA USA ; Department of Genetics; Stanford University School of Medicine; Stanford, CA USA.
authors.forename: Badreddin
authors.initials: B
authors.lastname: Edris
authors.forename: Stephen
authors.initials: S
authors.lastname: Willingham
authors.forename: Kipp
authors.initials: K
authors.lastname: Weiskopf
authors.forename: Anne K
authors.initials: AK
authors.lastname: Volkmer
authors.forename: Jens-Peter
authors.initials: JP
authors.lastname: Volkmer
authors.forename: Thomas
authors.initials: T
authors.lastname: Mühlenberg
authors.forename: Irving L
authors.initials: IL
authors.lastname: Weissman
authors.forename: Matt
authors.initials: M
authors.lastname: van de Rijn
keywords: CD117; KIT; gastrointestinal stromal tumor; imatinib; monoclonal antibody-based cancer therapy; receptor tyrosine kinase
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