title: Inflammation and thrombosis in cardiovascular disease.
abstract: OBJECTIVE
  This article will summarize recent observations that provide mechanistic insight into the molecular and cellular links between inflammation and thrombosis in the context of cardiovascular and other thromboinflammatory disease states.
  
  
  RESULTS
  Several disease conditions are characterized by a thromboinflammatory state in which interactions of blood cells and components with the vascular wall perpetuate both thrombotic and inflammatory pathways. Targeting these pathways may be of benefit in inflammatory conditions and cardiovascular disease.
  
  
  CONCLUSIONS
  Ongoing clinical trials should provide additional insight into the hypothesis that the thromboinflammatory state contributes to adverse clinical outcomes.
authors.affiliation: Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, Lexington, Kentucky 40536-0200, USA.
authors.forename: Prabhakara
authors.initials: P
authors.lastname: Nagareddy
authors.forename: Susan S
authors.initials: SS
authors.lastname: Smyth
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000502:physiology; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000503:physiopathology*; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D009504:Neutrophils / Q000502:physiology; D013927:Thrombosis / Q000503:physiopathology*
chemical_list: D000893:Anti-Inflammatory Agents; D005343:Fibrinolytic Agents
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