title: [Elevated levels of leptin and LDL-cholesterol in patients with well controlled congenital adrenal hyperplasia].
abstract: OBJECTIVE
  The objective of this study was to evaluate patients with classic CAH before and after treatment with glucocorticoids/mineralocorticoid and compare the metabolic profile of the well controlled (WC) and poorly controlled (PC) group.
  
  
  METHODS
  We selected newly diagnosed patients and patients monitored for CAH, classical form, regularly using or not glucocorticoids/mineralocorticoid in the Genetics Service Hupes-UFBA, seen from March/2004 to May/2006. All patients underwent detailed clinical evaluation and laboratory tests (glucose, sodium and potassium; total cholesterol, HDL, LDL, triglycerides and uric acid; leptin, 17-hydroxyprogesterone, total testosterone, C peptide, and insulin). Patients with normal androgens were classified as well controlled (WC), and those with high levels of androgens either using or not glucocorticoids/mineralocorticoids were classified as poorly controlled (PC).
  
  
  RESULTS
  We studied 41 patients with CAH: 11 in the WC group and 30 in PC group. Leptin and LDL cholesterol levels were higher in WC than in the PC group (p < 0.05). Uric acid values were lower in WC compared with the PC group (p < 0.05).
  
  
  CONCLUSIONS
  Adequate control of CAH with steroids seems safe, as it is associated with only mild changes in lipid profile and leptin values. No other metabolic abnormality was associated with glucocorticoid use. The reason for lower uric acid levels found in WC CAH patients is unknown and should be further studied.
authors.affiliation: Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BA, Brasil. lmboliveira@hotmail.com
authors.forename: Luciana Mattos Barros
authors.initials: LM
authors.lastname: Oliveira
authors.forename: José Antônio Diniz
authors.initials: JA
authors.lastname: Faria
authors.forename: Daniela
authors.initials: D
authors.lastname: Nunes-Silva
authors.forename: Renata
authors.initials: R
authors.lastname: Lago
authors.forename: Maria Betânia Pereira
authors.initials: MB
authors.lastname: Toralles
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood* / Q000188:drug therapy; D000328:Adult; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D020738:Leptin / Q000097:blood*; D008297:Male; D055442:Metabolome / Q000187:drug effects*; D008901:Mineralocorticoids / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D008078:Cholesterol, LDL; D005938:Glucocorticoids; D020738:Leptin; D008901:Mineralocorticoids; D014527:Uric Acid