title: Enhanced photodynamic efficiency of an aptamer-guided fullerene photosensitizer toward tumor cells.
abstract: Fullerene-based photosensitizers exhibit great potential in photodynamic therapy (PDT). Based on the high photodynamic efficacy of trimalonic acid-modified C70 fullerene (TF70), we constructed an aptamer-guided TF70 photosensitizer and investigated its photodynamic effect. Conjugation of the novel aptamer (named R13) could effectively enhance the PDT efficiency of TF70 against A549 lung cancer cells in the presence of serum. The lysosomal location of the TF70-R13 conjugate inside cells facilitates the production of intracellular reactive oxygen species (ROS), which can efficiently kill cells, under light irradiation. The enhanced photodynamic efficiency, along with its good biocompatibility in the dark, makes TF70-R13 a highly promising photosensitizer for tumor-specific PDT.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructures and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: (+86) 1062561085.
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Xuejie
authors.initials: X
authors.lastname: Zhang
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Junpeng
authors.initials: J
authors.lastname: Zheng
authors.forename: Mirong
authors.initials: M
authors.lastname: Guan
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Fang
authors.forename: Chunru
authors.initials: C
authors.lastname: Wang
authors.forename: Chunying
authors.initials: C
authors.lastname: Shu
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D008027:Light; D008175:Lung Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide; D037741:Fullerenes; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; C069836:fullerene C70
keywords: aptamers; cancer; fullerenes; nanoparticles; photodynamic therapy