title: Decreased plasma apolipoprotein A-IV levels in patients with acute coronary syndrome.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the relationship between apolipoprotein A-IV (apoA-IV) plasma concentrations and acute coronary syndrome (ACS).
  
  
  METHODS
  Plasma apoA-IV concentrations were measured in 115 patients with different types of ACS and in 68 gender- and age-matched control subjects using Enzyme-Linked Immunosorbent Assay (ELISA) kits. The clinical data were collected by an internist, who was blinded to plasma apoA-IV concentrations.
  
  
  RESULTS
  Plasma apoA-IV levels in ACS patients were significantly decreased compared to the levels in control subjects (437.0±157.5 μg/mL vs. 590.2±183.7 μg/mL, P<0.001). An statistically significant decreasing trend of plasma apoA-IV levels from the control subjects, to patients with unstable angina pectoris (UAP) (457.3±152.9 μg/mL), to patients with acute myocardial infarction (AMI) (311.7±127.8 μg/mL), was observed. Moreover, plasma apoA-IV level was negatively associated with New York Heart Association (NYHA) functional class. NYHA class II (467.2±142.1 μg/mL, P<0.001) and class III/IV (368.1±170.8 μg/mL, P<0.001) patients had statistically decreased levels of plasma apoA-IV when compared to the control subjects. A stepwise multivariate regression analysis identified types of ACS, NYHA classes, and plasma fibrinogen levels as the most important determinants of plasma apoA-IV levels in ACS patients.
  
  
  CONCLUSIONS
  Low plasma apoA-IV levels are associated with ACS, and plasma apoA-IV levels may be a potential treatment target for ACS patients.
authors.affiliation: Institute of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China
authors.forename: Jiabei
authors.initials: J
authors.lastname: Li
authors.forename: Mingbao
authors.initials: M
authors.lastname: Song
authors.forename: Dehui
authors.initials: D
authors.lastname: Qian
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Guoyan
authors.initials: G
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Jin
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wu
authors.forename: Lan
authors.initials: L
authors.lastname: Huang
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D001054:Apolipoproteins A / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001054:Apolipoproteins A; C022205:apolipoprotein A-IV