title: Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals.
abstract: A new rhodamine fluorescent probe for monitoring ˙OH has been developed based on the oxidative C-H abstraction reaction of rhodamine cyclic hydrazide. The probe exhibits excellent selectivity for ˙OH with virtually no interference by other ROS/RNS species. Fluorescent imaging of A549 and RAW264.7 cells is also successfully demonstrated to detect intracellular ˙OH in live cells.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Korea. jstae@yonsei.ac.kr injae@yonsei.ac.kr.
authors.forename: Minjeong
authors.initials: M
authors.lastname: Kim
authors.forename: Sung-Kyun
authors.initials: SK
authors.lastname: Ko
authors.forename: Hyemi
authors.initials: H
authors.lastname: Kim
authors.forename: Injae
authors.initials: I
authors.lastname: Shin
authors.forename: Jinsung
authors.initials: J
authors.lastname: Tae
mesh_terms: D002478:Cells, Cultured; D003500:Cyclization; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006834:Hydrazines / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000032:analysis* / Q000737:chemistry; D057230:Limit of Detection; D015394:Molecular Structure; D012235:Rhodamines / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D006834:Hydrazines; D012235:Rhodamines; D017665:Hydroxyl Radical