title: Subclinical myocardial dysfunction in multiple sclerosis patients remotely treated with mitoxantrone: evidence of persistent diastolic dysfunction.
abstract: BACKGROUND
  Mitoxantrone is an effective disease-modifying therapy in multiple sclerosis (MS), but its use is limited by cardiotoxicity. We evaluated global myocardial function, including myocardial performance index (MPI), on echocardiography in MS patients after remote mitoxantrone treatment.
  
  
  RESULTS
  Consecutive patients (n = 50) treated with standard-protocol mitoxantrone from 2002 to 2010 in our center were identified. After exclusion of those who had died (n = 4; all noncardiac) or had developed interim cardiovascular disease or risk factors (n = 3), 33 (mean age 49 ± 11 years, 45% male, median follow-up 77 months, mean cumulative dose 72 mg/m(2)) of the remaining patients (77%) underwent 2-dimensional echocardiography. A comparison group of 17 age- and sex-matched control subjects were included. No significant differences occurred in standard echocardiographic parameters between groups. However, mean MPI (defined as isovolumic contraction time plus isovolumic relaxation time (IVRT) divided by ejection time) was significantly higher in patients (0.51 ± 0.12 vs 0.39 ± 0.06; P = .02) owing to a significantly prolonged IVRT (81 ± 25 vs 60 ± 9 ms; P = .04). Overall MPI was >0.5 in 18 patients compared with none of the control subjects (54.5% vs 0%; P < .001).
  
  
  CONCLUSIONS
  A subclinical form of global myocardial dysfunction reflecting primarily diastolic dysfunction may be present in MS patients after remote standard-dose mitoxantrone treatment.
authors.affiliation: Department of Cardiology, Mater Misericordiae University Hospital, Dublin, Ireland. emerjoyce@yahoo.co.uk
authors.forename: Emer
authors.initials: E
authors.lastname: Joyce
authors.forename: Eoin
authors.initials: E
authors.lastname: Mulroy
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Scott
authors.forename: Jane
authors.initials: J
authors.lastname: Melling
authors.forename: Carole
authors.initials: C
authors.lastname: Goggin
authors.forename: Catherine
authors.initials: C
authors.lastname: McGorrian
authors.forename: Killian
authors.initials: K
authors.lastname: O'Rourke
authors.forename: Timothy
authors.initials: T
authors.lastname: Lynch
authors.forename: Niall
authors.initials: N
authors.lastname: Mahon
mesh_terms: D000328:Adult; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D003971:Diastole / Q000187:drug effects / Q000502:physiology; D015150:Echocardiography, Doppler / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D008942:Mitoxantrone
keywords: Echocardiography; Tei index; cardiotoxicity; diastolic function