title: Antibody-drug conjugate payloads.
abstract: Toxin payloads, or drugs, are the crucial components of therapeutic antibody-drug conjugates (ADCs). This review will give an introduction on the requirements that make a toxic compound suitable to be used in an antitumoral ADC and will summarize the structural and mechanistic features of four drug families that yielded promising results in preclinical and clinical studies.
authors.affiliation: Heidelberg Pharma GmbH, Ladenburg, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Anderl
authors.forename: Heinz
authors.initials: H
authors.lastname: Faulstich
authors.forename: Torsten
authors.initials: T
authors.lastname: Hechler
authors.forename: Michael
authors.initials: M
authors.lastname: Kulke
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry / Q000494:pharmacology*; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D018796:Immunoconjugates; D004364:Pharmaceutical Preparations