title: Aspergillosis sinusitis with cranio-orbital spread in an apparently immunocompetent patient.
abstract: Intracranial fungal infections are unusual and typically described in immunocompromised hosts. The authors describe a rare case of an immunocompetent white man presenting with blindness after Aspergillus fumigatus infection of the ethmoidal air sinus with spread to the orbital apex and the frontal lobe. This was successfully treated by surgical drainage via a frontal craniotomy and long-term antifungal therapy with voriconazole.
authors.affiliation: Department of Neurosurgery, Manchester Skull Base Unit, Greater Manchester Neurosciences Centre, Salford Royal Hospital, Manchester, United Kingdom.
authors.forename: Navneet
authors.initials: N
authors.lastname: Singh
authors.affiliation: Department of Neurosurgery, Manchester Skull Base Unit, Greater Manchester Neurosciences Centre, Salford Royal Hospital, Manchester, United Kingdom.
authors.forename: Adarsh
authors.initials: A
authors.lastname: Nadig
authors.affiliation: Department of Neuropathology, Manchester Skull Base Unit, Greater Manchester Neurosciences Centre, Salford Royal Hospital, Manchester, United Kingdom.
authors.forename: Piyali
authors.initials: P
authors.lastname: Pal
authors.affiliation: Department of Microbiology, Manchester Skull Base Unit, Greater Manchester Neurosciences Centre, Salford Royal Hospital, Manchester, United Kingdom.
authors.forename: Chinari P K
authors.initials: CP
authors.lastname: Subudhi
authors.affiliation: Department of Neurosurgery, Manchester Skull Base Unit, Greater Manchester Neurosciences Centre, Salford Royal Hospital, Manchester, United Kingdom.
authors.forename: Kanna
authors.initials: K
authors.lastname: Gnanalingham
mesh_terms: D000368:Aged; D000935:Antifungal Agents; D001228:Aspergillosis / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D001232:Aspergillus fumigatus; D001766:Blindness / Q000209:etiology; D001921:Brain / Q000473:pathology*; D003131:Combined Modality Therapy; D003646:Debridement; D006801:Humans; D016867:Immunocompromised Host; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures; D009886:Ophthalmoplegia / Q000209:etiology; D009915:Orbit / Q000473:pathology*; D011743:Pyrimidines / Q000627:therapeutic use; D012852:Sinusitis / Q000209:etiology / Q000382:microbiology / Q000628:therapy*; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole