title: KGM and PMAA based pH-sensitive interpenetrating polymer network hydrogel for controlled drug release.
abstract: Sequential interpenetrating polymer networks (IPN) hydrogels based on konjac glucomannan (KGM) and poly(methacrylic acid) (PMAA) were prepared by immersion of a solution of methacrylic acid (MAA) monomer with cross-linker N,N'-methylenebisacrylamide (MBAAm) and initiating into a pre-fabricated dried KGM gel. Polymerization and cross-linking of MAA inside the KGM network resulted in a novel biodegradable pH-sensitive IPN hydrogel. The studies on the swelling behavior of IPN hydrogels reveal their sensitive response to environment pH value. It was possible to modulate the degree of swelling of the IPN gels by changing the KGM/PMAA ratio and the cross-linking density of the PMAA component. The KGM component in the IPN can be degraded by β-glycosidase Mannaway25L. In vitro drug release behavior of IPN hydrogels were investigated under different environments using model drugs 5-fluorouracil. The results suggested that such an IPN hydrogel can be exploited as carrier candidate for colon-specific drug delivery.
authors.affiliation: Key Laboratory of Green Processing and Function Texiles of New Materials of Ministry of Education, Wuhan University of Science and Engineering, Wuhan 430073, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Weijuan
authors.initials: W
authors.lastname: Huang
authors.forename: Linbin
authors.initials: L
authors.lastname: Jiang
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Lei
authors.forename: Xueyong
authors.initials: X
authors.lastname: Li
authors.forename: Hongbing
authors.initials: H
authors.lastname: Deng
mesh_terms: D002021:Buffers; D003692:Delayed-Action Preparations / Q000737:chemistry*; D005472:Fluorouracil / Q000494:pharmacology; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008351:Mannans / Q000737:chemistry*; D008970:Molecular Weight; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D002021:Buffers; D003692:Delayed-Action Preparations; D008351:Mannans; D011109:Polymethacrylic Acids; D012996:Solutions; C030613:polymethacrylic acid; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C022901:(1-6)-alpha-glucomannan; D005472:Fluorouracil
keywords: Controlled drug release; Hydrogel; Interpenetrating polymer network; Konjac glucomannan; Poly(methacrylic acid); pH-sensitivity