title: Nongenomic effect of levothyroxine on the synchronous electrical activity of the spinal dorsal horn in the rat.
abstract: Levothyroxine (T4) has a well-known effect on the central nervous system (CNS). This effect requires hours of latency by genetic pathway. We tested for short latency nongenomic effects of T4 superfusion on the spinal dorsal horn (DH) evaluating lumbar somatosensory evoked potentials in rats. T4 increased N and P wave amplitudes and N wave area under the curve, but reduced P wave duration and N-P interval, suggesting that T4 exerts both excitatory and synchronizing effects on DH interneurons in less than 300 s, thus, providing evidence of nongenomic effects of T4 on DH.
authors.affiliation: Dpto. de Biología, Facultad de Ciencias y Tecnología, Universidad de Carabobo , Valencia , Venezuela .
authors.forename: Verónika
authors.initials: V
authors.lastname: Storaci
authors.forename: Antonio
authors.initials: A
authors.lastname: Eblen-Zajjur
mesh_terms: D000818:Animals; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D008297:Male; D020671:Posterior Horn Cells / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013974:Thyroxine / Q000494:pharmacology*
chemical_list: D013974:Thyroxine