title: Neuroinflammation in Alzheimer's disease: an understanding of physiology and pathology.
abstract: Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex etiology. Neuroinflammation has been found to be an underlying cause of the disease, although it demonstrates significant defensive role and renders the brain immunologically secured. This review focuses on the physiology and pathology of this crucial biological process and the diverse factors involved in and acting in a concerted manner to play a pivotal role either in the physiology or pathology of the disease. We used Pubmed, Pubmed Central, and Medline databases for a period of 3 months. It also summarizes the recent advances in neuroinflammation in both in vitro and in vivo. This review eventually warrants further studies on animal models of AD to unravel the complete pathophysiology of the disease and also accentuates the burgeoning need to protect astrocytes which can become a substantial therapeutic avenue.
authors.affiliation: 1Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba , Tsukuba, Ibaraki , Japan.
authors.forename: M
authors.initials: M
authors.lastname: Obulesu
authors.forename: M
authors.initials: M
authors.lastname: Jhansilakshmi
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000502:physiology; D000818:Animals; D001253:Astrocytes / Q000473:pathology / Q000502:physiology; D001792:Blood Platelets / Q000473:pathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D019013:CD40 Antigens / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D017628:Microglia / Q000473:pathology / Q000502:physiology; D016875:tau Proteins / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D019013:CD40 Antigens; D016875:tau Proteins