title: [Acute non-traumatic myelopathy in children and adolescents].
abstract: The term 'acute myelopathies'--referred to a spinal cord dysfunction--represent a heterogeneous group of disorders with distinct etiologies, clinical and radiologic features, and prognoses. The objective of this review is to discuss the non-traumatic acute myelopathies. Acute myelopathy can be due to several causes as infective agents or inflammatory processes, such as in acute myelitis, compressive lesions, vascular lesions, etc. The clinical presentation is often dramatic with tetraparesis or paraparesis, sensory disturbances and bladder and/or bowel dysfunction. History and physical examination are used to localize the lesion to the root or specific level of the cord, which can guide imaging. Different syndromes are recognized: complete transverse lesion, central grey matter syndrome, anterior horn syndrome, anterior spinal artery syndrome, etc). The first priority is to rule out a compressive lesion. If a myelopathy is suspected, a gadolinium-enhanced MRI of the spinal cord should be obtained as soon as possible. If there is no structural lesion such as epidural blood or a spinal mass, then the presence or absence of spinal cord inflammation should be documented with a lumbar puncture. The absence of pleocytosis would lead to consideration of non inflammatory causes of myelopathy such as arteriovenous malformations, fibrocartilaginous embolism, or possibly early inflammatory myelopathy. In the presence of an inflammatory process (defined by gadolinium enhancement, cerebrospinal fluid pleocytosis, or elevated cerebrospinal fluid immunoglobulin index), one should determine whether there is an inflammatory or an infectious cause. Different virus, bacterias, parasites and fungi have to be considered as autoimmune and inflammatory diseases that involve the central nervous system.
authors.affiliation: Hospital de Pediatria SAMIC. Prof. Dr. J.P. Garrahan, Buenos Aires, Argentina.
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Arroyo
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D020274:Autoimmune Diseases of the Nervous System / Q000175:diagnosis; D002648:Child; D003711:Demyelinating Diseases / Q000175:diagnosis; D003937:Diagnosis, Differential; D020802:Epidural Abscess / Q000175:diagnosis; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000209:etiology; D009187:Myelitis / Q000175:diagnosis / Q000209:etiology; D009188:Myelitis, Transverse / Q000175:diagnosis; D059906:Neuroimaging; D010146:Pain / Q000209:etiology; D011782:Quadriplegia / Q000209:etiology; D012678:Sensation Disorders / Q000209:etiology; D013116:Spinal Cord / Q000098:blood supply; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000209:etiology; D013118:Spinal Cord Diseases / Q000145:classification / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013120:Spinal Cord Neoplasms / Q000150:complications / Q000175:diagnosis