title: Mussel-inspired modification of dextran for protein-resistant coatings of titanium oxide.
abstract: Surface modification of inorganic materials to prevent non-specific protein adsorption is critically important for developing a biocompatible materials' platform for medical implantation, diagnostics, and therapeutics. Here we report mussel-inspired chemical modification of dextran for anti-fouling coatings of metal oxide. Catechols are conjugated to dextran via a carbamate ester linkage, producing catechol-grafted dextran with a grafting density of 7.3 mol.%. Titanium dioxide (TiO₂) is coated with the catechol-grafted dextran, and the anti-fouling effect of dextran coatings is examined by using the adsorption of human serum albumin. The mussel-inspired dextran coatings show excellent resistance to non-specific protein adsorption: the adsorption equilibrium constant (K) is 0.69 Lg(-1) for dextran-coated TiO₂ while that for pristine TiO₂ surface is 3.53 Lg(-1). This study suggests that catechol-grafted dextran is a promising material for effective anti-fouling coatings of implantable inorganic materials.
authors.affiliation: Department of Material Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea.
authors.forename: Jae Yoon
authors.initials: JY
authors.lastname: Park
authors.forename: Jee Seon
authors.initials: JS
authors.lastname: Kim
authors.forename: Yoon Sung
authors.initials: YS
authors.lastname: Nam
mesh_terms: D000818:Animals; D057219:Biofouling / Q000517:prevention & control; D049872:Bivalvia / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003911:Dextrans / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D056951:Photoelectron Spectroscopy; D012709:Serum Albumin / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature; D014025:Titanium / Q000494:pharmacology*
chemical_list: D020099:Coated Materials, Biocompatible; D003911:Dextrans; D012709:Serum Albumin; C009495:titanium dioxide; D014025:Titanium
keywords: Anti-fouling; Catechol; Dextran; Protein adsorption; Titanium dioxide