title: A 2-hit model for chronic GVHD.
abstract: In this issue of Blood, Dertschnig and colleagues1 demonstrate in mice that acute graft-versus-host disease (GHVD) results in a marked reduction of autoimmune receptor–expressing medullary thymic epithelial cells (Aire1 mTEC) and a decrease in the diversity of Aire-dependent tissue-restricted peripheral selfantigens (TRAs) required for effective negative thymic selection. Both of these abnormalities are reversed by the peritransplant administration of the epithelial protectant drug, fibroblast growth factor 7(Fgf7).
authors.affiliation: Children's Hospital Los Angeles.
authors.forename: Robertson
authors.initials: R
authors.lastname: Parkman
mesh_terms: D000818:Animals; D000941:Antigens / Q000235:genetics*; D004847:Epithelial Cells / Q000276:immunology*; D005260:Female; D006086:Graft vs Host Disease / Q000235:genetics* / Q000276:immunology*; D013950:Thymus Gland / Q000378:metabolism*
chemical_list: D000941:Antigens