title: Behavioural and psychological symptoms of dementia in an Alzheimer's disease case successfully treated with natural medicine: association with gonadotropins.
abstract: Pharmacotherapies for the behavioural and psychological symptoms of dementia are limited; novel agents for the symptoms are still needed. Herein, we report the case of an 80-year-old male patient with Alzheimer's disease whose severe agitation, insomnia and sexual delusions were successfully treated with a traditional natural Japanese (Kampo) medicine, keishi-ka-ryukotsu-borei-to. We found that administrating keishi-ka-ryukotsu-borei-to increased his serum luteinizing hormone level, which could be inversely associated with his behavioural and psychological symptoms. This report suggests that keishi-ka-ryukotsu-borei-to is a possible alternative treatment for the behavioural and psychological symptoms of dementia, especially sexual delusions.
authors.affiliation: Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan. niitsu@chiba-u.jp
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Niitsu
authors.forename: Hideki
authors.initials: H
authors.lastname: Okamoto
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000523:psychology; D001526:Behavioral Symptoms / Q000188:drug therapy* / Q000209:etiology* / Q000523:psychology; D003702:Delusions / Q000209:etiology / Q000523:psychology; D003704:Dementia / Q000150:complications* / Q000523:psychology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D011595:Psychomotor Agitation / Q000209:etiology / Q000523:psychology; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology / Q000523:psychology; D013739:Testosterone / Q000097:blood; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D006062:Gonadotropins; C095444:saiko-ka-ryukotsu-borei-to; D013739:Testosterone; D007986:Luteinizing Hormone
keywords: BPSD; Kampo; keishi-ka-ryukotsu-borei-to; luteinizing hormone; sexual behaviour; testosterone