title: A Study of Various Histopathological Features and their Relevance in Pathogenesis of Psoriasis.
abstract: BACKGROUND
  The pathogenesis of psoriasis is still to be fully unraveled. The immunological theory with T cells at the centre of attraction and peripherally acting cytokines are the present favourites among aetiopathological factors. Histopathology of the skin lesions offers a good study model to understand the pathogenesis of this complex disease.
  
  
  OBJECTIVE
  To study the various histopathological parameters of psoriatic lesions, and to establish their correlation with the pathogenesis of the disorder.
  
  
  METHODS
  Eighty eight consecutive histopathologically proven cases of psoriasis were included in the study. Eight common histopathological parameters of psoriasis present in these biopsies were assessed and graded. We then statistically analyzed the relationship of the factors with one another and attempted to establish a better understanding of the pathogenesis of disease.
  
  
  RESULTS
  Significant correlations were found between degree of epidermal hyperplasia and inflammatory infiltrate, grade of inflammation and pustules of Kogoj, inflammatory infiltrate and grade of capillary proliferation as also between epidermal hyperplasia and the presence of parakeratosis.
  
  
  CONCLUSIONS
  The study suggests that the immunopathogenesis of psoriasis is predominantly based on the inflammatory response. This is in consonance with other studies which have suggested that psoriasis is primarily a T lymphocyte based disease. Several treatment modalities are now based on this concept and it is hoped that the future treatment modalities will focus on the central role of inflammatory cells in the pathogenesis of this enigmatic disease.
authors.affiliation: Departments of Pathology and Dermatology, Armed Forces Medical College, Pune, India.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Moorchung
authors.forename: Js
authors.initials: J
authors.lastname: Khullar
authors.forename: Ns
authors.initials: N
authors.lastname: Mani
authors.forename: Manas
authors.initials: M
authors.lastname: Chatterjee
authors.forename: Biju
authors.initials: B
authors.lastname: Vasudevan
authors.forename: Tanu
authors.initials: T
authors.lastname: Tripathi
keywords: Epidermal hyperplasia; histopathology; inflammation pathogenesis; psoriasis
references.citation: J Neuroimmunol. 1998 Aug 14;89(1-2):43-50
references.pmid: 9726824
references.citation: Ann Rheum Dis. 2005 Mar;64 Suppl 2:ii30-6
references.pmid: 15708932
references.citation: Arch Dermatol. 1992 Nov;128(11):1479-85
references.pmid: 1359841
references.citation: Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4):751-60
references.pmid: 17166397
references.citation: Indian J Dermatol. 2009;54(1):7-12
references.pmid: 20049260
references.citation: J Immunol. 2004 Apr 1;172(7):4618-23
references.pmid: 15034080
references.citation: Arch Dermatol Res. 1983;275(3):181-9
references.pmid: 6604503
references.citation: Br J Dermatol. 1999 Apr;140 Suppl 54:1-7
references.pmid: 10731127
references.citation: Lancet. 2001 Jun 9;357(9271):1842-7
references.pmid: 11410193
references.citation: J Immunol. 1991 Jun 1;146(11):3815-23
references.pmid: 1827816
references.citation: J Am Acad Dermatol. 2003 Aug;49(2 Suppl):S87-97
references.pmid: 12894131
references.citation: Int Arch Allergy Immunol. 1996 Jul;110(3):199-206
references.pmid: 8688665
references.citation: Immunol Today. 1999 Jan;20(1):40-6
references.pmid: 10081229
references.citation: N Engl J Med. 2005 May 5;352(18):1899-912
references.pmid: 15872205
references.citation: Curr Opin Pharmacol. 2004 Jun;4(3):306-10
references.pmid: 15140425