title: Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans.
abstract: Many animal species live in close association with commensal and symbiotic microbes (microbiota). Recent studies have revealed that the status of gastrointestinal tract microbiota can influence nutrition-related syndromes such as obesity and type-2 diabetes, and perhaps aging. These morbidities have a profound impact in terms of individual suffering, and are an increasing economic burden to modern societies. Several theories have been proposed for the influence of microbiota on host metabolism, but these largely remain to be proven. In this article we discuss how microbiota may be manipulated (via pharmacology, diet, or gene manipulation) in order to alter metabolism, immunity, health and aging in the host. The nematode Caenorhabditis elegans in combination with one microbial species is an excellent, defined model system to investigate the mechanisms of host-microbiota interactions, particularly given the combined power of worm and microbial genetics. We also discuss the multifaceted nature of the worm-microbe relationship, which likely encompasses predation, commensalism, pathogenicity and necromeny.
authors.affiliation: Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK. f.cabreiro@ucl.ac.uk
authors.forename: Filipe
authors.initials: F
authors.lastname: Cabreiro
authors.forename: David
authors.initials: D
authors.lastname: Gems
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000382:microbiology* / Q000502:physiology*; D064307:Microbiota; D023421:Models, Animal; D013559:Symbiosis
keywords: C. elegans; aging; metformin; microbiota; type-2 diabetes
references.citation: Mech Ageing Dev. 1977 Nov-Dec;6(6):413-29
references.pmid: 926867
references.citation: Cell. 2012 Mar 16;148(6):1258-70
references.pmid: 22424233
references.citation: Science. 2012 Jun 8;336(6086):1253-5
references.pmid: 22674325
references.citation: EMBO J. 2003 Apr 1;22(7):1451-60
references.pmid: 12660152
references.citation: Cell. 2013 Mar 28;153(1):228-39
references.pmid: 23540700
references.citation: Science. 2011 Nov 4;334(6056):670-4
references.pmid: 22053049
references.citation: Nature. 2010 Mar 25;464(7288):504-12
references.pmid: 20336132
references.citation: J Food Prot. 2011 Jan;74(1):86-93
references.pmid: 21219766
references.citation: Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10892-7
references.pmid: 11535834
references.citation: Biogerontology. 2013 Feb;14(1):73-87
references.pmid: 23291976
references.citation: BMC Biol. 2012 Jun 25;10:59
references.pmid: 22731941
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703
references.pmid: 19234110
references.citation: Oncogene. 2013 Mar 21;32(12):1475-87
references.pmid: 22665053
references.citation: Immunol Rev. 2004 Apr;198:36-58
references.pmid: 15199953
references.citation: Cell Cycle. 2008 Sep 1;7(17):2769-73
references.pmid: 18728386
references.citation: BMC Biol. 2012 Jul 31;10:67
references.pmid: 22849329
references.citation: Brief Bioinform. 2012 Nov;13(6):751-68
references.pmid: 22445903
references.citation: Dis Model Mech. 2011 May;4(3):300-4
references.pmid: 21504910
references.citation: Aging Cell. 2011 Aug;10(4):699-710
references.pmid: 21501374
references.citation: J Diabetes Complications. 2007 Mar-Apr;21(2):118-23
references.pmid: 17331860
references.citation: Curr Biol. 2007 Oct 9;17(19):1646-56
references.pmid: 17900900
references.citation: Appl Environ Microbiol. 2007 Oct;73(20):6404-9
references.pmid: 17704266
references.citation: Trends Endocrinol Metab. 2011 Apr;22(4):117-23
references.pmid: 21353592
references.citation: Jikken Dobutsu. 1991 Oct;40(4):517-22
references.pmid: 1748169
references.citation: Mol Microbiol. 2013 Mar;87(5):939-50
references.pmid: 23350972
references.citation: Science. 2012 Jun 8;336(6086):1262-7
references.pmid: 22674330
references.citation: Science. 2011 May 20;332(6032):970-4
references.pmid: 21596990
references.citation: PLoS Biol. 2012;10(11):e1001424
references.pmid: 23185130
references.citation: J Nutr. 2012 Feb;142(2):213-20
references.pmid: 22223580
references.citation: Cell. 2011 Nov 11;147(4):840-52
references.pmid: 22035958
references.citation: PLoS Biol. 2010 May 25;8(5):e1000376
references.pmid: 20520844
references.citation: BMC Med. 2011 Apr 06;9:33
references.pmid: 21470407
references.citation: Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13091-6
references.pmid: 9789046
references.citation: Ageing Res Rev. 2013 Jan;12(1):436-44
references.pmid: 22706186
references.citation: Birth Defects Res C Embryo Today. 2011 Mar;93(1):56-66
references.pmid: 21425442
references.citation: BMC Microbiol. 2012 Mar 27;12:49
references.pmid: 22452899
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4596-601
references.pmid: 15070763
references.citation: Biogerontology. 2011 Dec;12(6):599-609
references.pmid: 21814818
references.citation: PLoS One. 2011;6(10):e25482
references.pmid: 22022402
references.citation: Curr Opin Immunol. 2012 Feb;24(1):3-9
references.pmid: 22236697
references.citation: Trends Immunol. 2012 Sep;33(9):459-66
references.pmid: 22677185
references.citation: Dis Model Mech. 2011 Jul;4(4):447-56
references.pmid: 21669933
references.citation: Nat Rev Genet. 2012 Mar 13;13(4):260-70
references.pmid: 22411464
references.citation: Aliment Pharmacol Ther. 2001 Jan;15(1):137-42
references.pmid: 11136287
references.citation: Genetics. 2002 Jul;161(3):1101-12
references.pmid: 12136014
references.citation: Dig Liver Dis. 2005 Nov;37(11):838-49
references.pmid: 16169298
references.citation: Cell. 2013 Feb 14;152(4):818-30
references.pmid: 23415229
references.citation: BMC Evol Biol. 2012 Sep 21;12:187
references.pmid: 22998555
references.citation: Science. 2003 Jun 20;300(5627):1921
references.pmid: 12817143
references.citation: J Bacteriol. 2008 Sep;190(18):6197-203
references.pmid: 18586932
references.citation: Clin Microbiol Rev. 2006 Apr;19(2):315-37
references.pmid: 16614252
references.citation: Exp Anim. 1998 Jul;47(3):151-8
references.pmid: 9816490
references.citation: Cell. 2013 Jan 17;152(1-2):109-19
references.pmid: 23332749
references.citation: Annu Rev Microbiol. 1977;31:107-33
references.pmid: 334036
references.citation: Exp Gerontol. 1989;24(3):251-64
references.pmid: 2731582
references.citation: Genetics. 2000 Apr;154(4):1597-610
references.pmid: 10747056
references.citation: BMC Dev Biol. 2008 May 05;8:49
references.pmid: 18457595
references.citation: J Proteome Res. 2007 May;6(5):1846-54
references.pmid: 17411081
references.citation: Aging Cell. 2008 Jun;7(3):291-304
references.pmid: 18267002
references.citation: Mech Ageing Dev. 2005 Sep;126(9):929-37
references.pmid: 15896824
references.citation: Genetics. 1974 May;77(1):71-94
references.pmid: 4366476
references.citation: J Gerontol A Biol Sci Med Sci. 2008 Mar;63(3):242-52
references.pmid: 18375873
references.citation: Infect Immun. 2012 Jul;80(7):2500-8
references.pmid: 22585961
references.citation: Nat Commun. 2012;3:1073
references.pmid: 23011127
references.citation: PLoS One. 2009 Oct 21;4(10):e7545
references.pmid: 19844570
references.citation: BMC Microbiol. 2012 Dec 20;12:300
references.pmid: 23256533
references.citation: Aging Cell. 2006 Dec;5(6):487-94
references.pmid: 17081160
references.citation: Mol Genet Metab. 2010 Jul;100(3):274-82
references.pmid: 20400348
references.citation: Bioessays. 2010 Jul;32(7):571-80
references.pmid: 20544735
references.citation: Drug Metab Dispos. 2008 Aug;36(8):1650-8
references.pmid: 18458049
references.citation: Int J Food Microbiol. 2011 Aug 2;148(2):80-6
references.pmid: 21652104
references.citation: Nature. 2012 Aug 9;488(7410):178-84
references.pmid: 22797518
references.citation: Nature. 2011 Jun 15;474(7351):327-36
references.pmid: 21677749
references.citation: Curr Pharm Des. 2009;15(13):1546-58
references.pmid: 19442172
references.citation: PLoS One. 2009;4(2):e4535
references.pmid: 19229346
references.citation: Exp Gerontol. 2002 Dec;37(12):1371-8
references.pmid: 12559406
references.citation: PLoS Biol. 2008 Dec 9;6(12):2736-52
references.pmid: 19071962
references.citation: Nat Neurosci. 2011 Nov 13;15(1):107-12
references.pmid: 22081161
references.citation: Int J Parasitol. 2012 Jul;42(8):747-53
references.pmid: 22705203
references.citation: Nature. 2007 May 31;447(7144):545-9
references.pmid: 17538612
references.citation: PLoS Genet. 2011 May;7(5):e1002082
references.pmid: 21625567
references.citation: Aging Cell. 2009 Apr;8(2):113-27
references.pmid: 19239417
references.citation: EMBO Rep. 2006 Jul;7(7):688-93
references.pmid: 16819463
references.citation: Cell. 2013 Mar 28;153(1):240-52
references.pmid: 23540701
references.citation: Diabetes Obes Metab. 2012 Feb;14(2):112-20
references.pmid: 21812894
references.citation: Mech Ageing Dev. 2005 Sep;126(9):913-22
references.pmid: 15885745
references.citation: Biogerontology. 2010 Feb;11(1):53-65
references.pmid: 19444640
references.citation: Cell. 2013 Jan 17;152(1-2):39-50
references.pmid: 23332745
references.citation: Curr Opin Biotechnol. 2012 Apr;23(2):192-201
references.pmid: 22137452
references.citation: Clin Exp Allergy. 2000 Sep;30(9):1230-4
references.pmid: 10971468
references.citation: Trends Microbiol. 2005 Mar;13(3):119-27
references.pmid: 15737730
references.citation: PLoS One. 2010 Jan 18;5(1):e8758
references.pmid: 20090912
references.citation: Infect Immun. 2012 Mar;80(3):1288-99
references.pmid: 22184417
references.citation: Dis Model Mech. 2009 May-Jun;2(5-6):224-9
references.pmid: 19407330
references.citation: J Gerontol. 1990 Mar;45(2):B52-8
references.pmid: 2313040
references.citation: FASEB J. 2013 Feb;27(2):760-8
references.pmid: 23085995
references.citation: Diabetologia. 2008 Aug;51(8):1552-3
references.pmid: 18528677
references.citation: Biochem Soc Trans. 2011 Aug;39(4):1073-8
references.pmid: 21787350