title: The severe pathogenicity of alveolar macrophage-depleted ferrets infected with 2009 pandemic H1N1 influenza virus.
abstract: The in vivo role of alveolar macrophages in the infections with 2009 pandemic H1N1 influenza virus is not as yet known. Ferret study shows that alveolar macrophages are critical for lowering the risk of severe outcomes in 2009 pandemic H1N1 influenza virus infections. Up to 40% of the infected ferrets depleted of alveolar macrophages died, with elevated body temperature and major loss of body weight in contrast to infected ferrets not depleted of alveolar macrophages. The higher viral titers in the lungs were detected in infected ferrets depleted of alveolar macrophages than infected ferrets not depleted of alveolar macrophages 5 days after infection. The inflammatory chemokines were induced at greater levels in the lungs of infected ferrets depleted of alveolar macrophages than in those of infected ferrets not depleted of alveolar macrophages. Our study implies that alveolar macrophages are important for controlling the infections of 2009 pandemic H1N1 influenza virus.
authors.affiliation: Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea.
authors.forename: Heui Man
authors.initials: HM
authors.lastname: Kim
authors.forename: Young Myong
authors.initials: YM
authors.lastname: Kang
authors.forename: Keun Bon
authors.initials: KB
authors.lastname: Ku
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Park
authors.forename: Jung
authors.initials: J
authors.lastname: Yum
authors.forename: Jeong Cheol
authors.initials: JC
authors.lastname: Kim
authors.forename: Seo Yeon
authors.initials: SY
authors.lastname: Jin
authors.forename: Joo Sub
authors.initials: JS
authors.lastname: Lee
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Sang Heui
authors.initials: SH
authors.lastname: Seo
mesh_terms: D000818:Animals; D001831:Body Temperature; D001835:Body Weight; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005289:Ferrets; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology* / Q000472:pathogenicity*; D047589:Leukocyte Reduction Procedures; D008168:Lung / Q000473:pathology / Q000821:virology; D016676:Macrophages, Alveolar / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D016019:Survival Analysis
chemical_list: D016207:Cytokines
keywords: Alveolar macrophages; Inflammatory responses; Influenza virus