title: Role of multilayered amniotic membrane transplantation for the treatment of resistant corneal ulcers in North India.
abstract: To study the role of multilayer amniotic membrane transplantation (AMT) in the treatment of non-healing corneal ulcers. This study included 28 patients with non-healing bacterial corneal ulcers. AMT was performed using the 'overlay on-inlay' technique'. The outcome was assessed in terms of best corrected visual acuity (BCVA), corneal re-epithelization, graft/tissue edema and vascularity, graft melting, graft retraction, infection of graft and surface necrosis. The success rate of ulcer healing was 82.1 % (23 patients) 1 month after surgery, 78.5 % (22 patients) after 3 months and 75 % (21 patients) after 6 months. In the early post-operative period, BCVA deteriorated in all patients (perception of light to hand movement) but improved later. In 26 of the 28 patients (92.8 %) graft retraction occurred after 1 month and neovascularization was seen in 17 of the 28 patients (60.7 %). Multilayer AMT using an overlay on-inlay graft in non-healing bacterial corneal ulcers is a good option in terms of ulcer healing and symptomatic improvement.
authors.affiliation: Cornea & Glaucoma Services, Department of Ophthalmology, GSVM Medical College, Kanpur, Uttar Pradesh, India, drshalinimohan@gmail.com.
authors.forename: Shalini
authors.initials: S
authors.lastname: Mohan
authors.forename: Ina
authors.initials: I
authors.lastname: Budhiraja
authors.forename: Amit
authors.initials: A
authors.lastname: Saxena
authors.forename: Perwez
authors.initials: P
authors.lastname: Khan
authors.forename: S K
authors.initials: SK
authors.lastname: Sachan
mesh_terms: D000328:Adult; D000368:Aged; D000650:Amnion / Q000637:transplantation*; D003320:Corneal Ulcer / Q000601:surgery*; D015818:Eye Infections, Bacterial / Q000601:surgery*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D011446:Prospective Studies; D014792:Visual Acuity; D055815:Young Adult
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