title: Endometrioid adenocarcinoma with simultaneous endocervical and intestinal-type mucinous differentiation: report of a rare phenomenon and the immunohistochemical profile.
abstract: Intestinal differentiation in the endometrium is rare with only case reports in the international literature. We describe a case of simultaneous endocervical and intestinal-type mucinous differentiation with goblet cells arising in a FIGO grade 1 endometrioid adenocarcinoma. The patient had no involvement of the myometrium, cervix, or extra-uterine sites. There were no intestinal metaplastic changes of the endocervical canal. The etiology of this change is unknown, although recent reports suggest an association with hyperestrogenism.
  The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1209512176931698.
authors.affiliation: Department of Pathology and Laboratory Medicine, Women & Infants Hospital and the Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA. mquddus@wihri.org.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Buell-Gutbrod
authors.forename: C James
authors.initials: CJ
authors.lastname: Sung
authors.forename: W Dwayne
authors.initials: WD
authors.lastname: Lawrence
authors.forename: M Ruhul
authors.initials: MR
authors.lastname: Quddus
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018269:Carcinoma, Endometrioid / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D004717:Endometrium / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D020397:Goblet Cells / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D007150:Immunohistochemistry; D010535:Laparoscopy; D008875:Middle Aged; D009077:Mucins / Q000032:analysis*; D060787:Neoplasm Grading; D010052:Ovariectomy / Q000379:methods; D058994:Salpingectomy / Q000379:methods; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D009077:Mucins
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