title: Hypothyroxinemia induced by mild iodine deficiency deregulats thyroid proteins during gestation and lactation in dams.
abstract: The main object of the present study was to explore the effect on thyroidal proteins following mild iodine deficiency (ID)-induced maternal hypothyroxinemia during pregnancy and lactation. In the present study, we established a maternal hypothyroxinemia model in female Wistar rats by using a mild ID diet. Maternal thyroid iodine content and thyroid weight were measured. Expressions of thyroid-associated proteins were analyzed. The results showed that the mild ID diet increased thyroid weight, decreased thyroid iodine content and increased expressions of thyroid transcription factor 1, paired box gene 8 and Na+/I- symporter on gestational day (GD) 19 and postpartum days (PN) 21 in the maternal thyroid. Moreover, the up-regulated expressions of type 1 iodothyronine deiodinase (DIO1) and type 2 iodothyronine deiodinase (DIO2) were detected in the mild ID group on GD19 and PN21. Taken together, our data indicates that during pregnancy and lactation, a maternal mild ID could induce hypothyroxinemia and increase the thyroidal DIO1 and DIO2 levels.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, China. weiwei840403@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Min
authors.forename: Binbin
authors.initials: B
authors.lastname: Song
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Shan
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng
authors.forename: Qi
authors.initials: Q
authors.lastname: Xi
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D005260:Female; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism; D007453:Iodide Peroxidase / Q000235:genetics / Q000378:metabolism; D007455:Iodine / Q000172:deficiency*; D007774:Lactation / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D009929:Organ Size; D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors / Q000235:genetics / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D027981:Symporters / Q000235:genetics / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism* / Q000502:physiology; D000074482:Thyroid Nuclear Factor 1; D013974:Thyroxine / Q000097:blood*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D000097564:Iodothyronine Deiodinase Type II; D000099209:Sodium-Iodide Symporters
chemical_list: D007453:Iodide Peroxidase; D007455:Iodine; D009687:Nuclear Proteins; D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors; D027981:Symporters; D000074482:Thyroid Nuclear Factor 1; D013974:Thyroxine; D014157:Transcription Factors; D000097564:Iodothyronine Deiodinase Type II; D000099209:Sodium-Iodide Symporters; C000614412:NKX2-1 protein, human; C000614416:Nkx2-1 protein, rat; C499497:Pax8 protein, rat; C109812:iodothyronine deiodinase type I
references.citation: Endocr Rev. 2009 Jun;30(4):376-408
references.pmid: 19460960
references.citation: Physiol Rev. 2000 Jul;80(3):1083-105
references.pmid: 10893432
references.citation: Thyroid Res. 2010 Jun 09;3(1):3
references.pmid: 20529371
references.citation: J Biol Chem. 1995 Sep 29;270(39):23139-42
references.pmid: 7559458
references.citation: Thyroid. 2013 May;23(5):523-8
references.pmid: 23472655
references.citation: Clin Endocrinol (Oxf). 2003 Sep;59(3):282-8
references.pmid: 12919150
references.citation: Clin Endocrinol (Oxf). 2010 Dec;73(6):808-14
references.pmid: 20718765
references.citation: Clin Endocrinol (Oxf). 2007 Jul;67(1):34-40
references.pmid: 17437516
references.citation: Mol Cell Endocrinol. 1997 Aug 8;131(2):195-203
references.pmid: 9296378
references.citation: J Neuroendocrinol. 2013 Sep;25(9):852-62
references.pmid: 23763342
references.citation: Exp Clin Endocrinol Diabetes. 2001;109(1):27-31
references.pmid: 11573135
references.citation: Asia Pac J Clin Nutr. 2007;16(4):731-7
references.pmid: 18042536
references.citation: Mol Cell Endocrinol. 2012 Jul 6;358(1):36-45
references.pmid: 22370158
references.citation: J Clin Endocrinol Metab. 1997 Oct;82(10):3331-6
references.pmid: 9329364
references.citation: Thyroid. 2003 Feb;13(2):141-8
references.pmid: 12699588
references.citation: J Nutr. 1993 Nov;123(11):1939-51
references.pmid: 8229312
references.citation: Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13144-9
references.pmid: 11069301
references.citation: Endocr Rev. 2008 Dec;29(7):898-938
references.pmid: 18815314
references.citation: Endocrinology. 1976 Jul;99(1):270-80
references.pmid: 939196
references.citation: J Thyroid Res. 2010;2010:619013
references.pmid: 21048839
references.citation: Cancer Res. 1994 Sep 1;54(17):4744-9
references.pmid: 8062273
references.citation: Biochem Biophys Res Commun. 1997 Nov 17;240(2):488-91
references.pmid: 9388506
references.citation: Thyroid. 1994 Spring;4(1):107-28
references.pmid: 8054857
references.citation: Development. 1990 Oct;110(2):643-51
references.pmid: 1723950
references.citation: Nat Rev Endocrinol. 2012 Nov;8(11):650-8
references.pmid: 23007317
references.citation: Trends Endocrinol Metab. 2007 Nov;18(9):338-43
references.pmid: 17962037
references.citation: Mol Endocrinol. 1997 Oct;11(11):1747-55
references.pmid: 9328356
references.citation: J Clin Endocrinol Metab. 2010 Sep;95(9):4227-34
references.pmid: 20534757
references.citation: Mol Endocrinol. 2003 Nov;17(11):2295-302
references.pmid: 12907760
references.citation: Mol Endocrinol. 2002 Oct;16(10):2266-82
references.pmid: 12351692
references.citation: J Clin Endocrinol Metab. 2004 Dec;89(12):6054-60
references.pmid: 15579758
references.citation: Prog Nucleic Acid Res Mol Biol. 2001;66:307-56
references.pmid: 11051768
references.citation: Endocrinology. 2001 Sep;142(9):3736-41
references.pmid: 11517148
references.citation: Proc Natl Acad Sci U S A. 1997 May 27;94(11):5568-73
references.pmid: 9159113
references.citation: Development. 1991 Dec;113(4):1093-104
references.pmid: 1811929
references.citation: J Clin Endocrinol Metab. 2000 Nov;85(11):3975-87
references.pmid: 11095417
references.citation: Gene Ther. 2012 Apr;19(4):435-42
references.pmid: 21833035
references.citation: BMC Cancer. 2005 Jul 19;5:80
references.pmid: 16029487
references.citation: Mol Cell Biol. 1999 Mar;19(3):2051-60
references.pmid: 10022892
references.citation: Nat Genet. 1998 May;19(1):87-90
references.pmid: 9590297
references.citation: J Biol Chem. 2003 Jan 31;278(5):3395-402
references.pmid: 12441357
references.citation: Endocrinology. 2006 May;147(5):2098-108
references.pmid: 16455775
references.citation: Endocrinology. 2013 Jan;154(1):529-36
references.pmid: 23142811
references.citation: J Clin Invest. 1973 Oct;52(10):2522-31
references.pmid: 4729046
references.citation: Arch Dis Child Fetal Neonatal Ed. 2004 Sep;89(5):F436-9
references.pmid: 15321965