title: Transient receptor potential channels and energy homeostasis.
abstract: Transient receptor potential (TRP) channels are members of an ancient class of ion channels that are present in most mammalian tissues. Consistent with their wide tissue distribution, TRPs are capable of influencing diverse physiological processes including adipocyte function, energy intake and energy expenditure. TRPs function as transduction channels downstream of G-protein-coupled receptors (GPCRs) and receptor tyrosine kinases, and some can also be direct sensors of chemical irritants that influence food intake or regulate body temperature and thermogenesis. TRP agonists were shown to reduce body weight and adiposity, suggesting that they might be exploited as therapeutic targets. In this review I discuss the current knowledge of how TRP channels influence energy balance.
authors.affiliation: Department of Pharmacology and Physiology, Georgetown University, Washington DC 20007, USA. Electronic address: gpa3@georgetown.edu.
authors.forename: Gerard P
authors.initials: GP
authors.lastname: Ahern
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: D050051:Transient Receptor Potential Channels
references.citation: Cell. 2006 Mar 24;124(6):1269-82
references.pmid: 16564016
references.citation: Nature. 2007 Jul 12;448(7150):204-8
references.pmid: 17538622
references.citation: Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G130-8
references.pmid: 17975130
references.citation: Circ Res. 2012 Jul 6;111(2):191-200
references.pmid: 22668831
references.citation: Annu Rev Physiol. 2006;68:619-47
references.pmid: 16460286
references.citation: Nature. 1997 Oct 23;389(6653):816-24
references.pmid: 9349813
references.citation: Nat Cell Biol. 2012 Aug;14(8):851-8
references.pmid: 22750945
references.citation: J Appl Physiol (1985). 2003 Dec;95(6):2408-15
references.pmid: 12959953
references.citation: Biosci Biotechnol Biochem. 2009 May;73(5):1021-7
references.pmid: 19420725
references.citation: Biosci Biotechnol Biochem. 2001 Dec;65(12):2735-40
references.pmid: 11826971
references.citation: Differentiation. 1996 Jun;60(3):151-8
references.pmid: 8766594
references.citation: Am J Physiol. 1998 Jul;275(1):R92-8
references.pmid: 9688965
references.citation: J Gastroenterol Hepatol. 1992 Jan-Feb;7(1):52-6
references.pmid: 1543869
references.citation: Pediatrics. 2003 Feb;111(2):321-7
references.pmid: 12563058
references.citation: Br J Nutr. 1999 Aug;82(2):115-23
references.pmid: 10743483
references.citation: Neuron. 2011 Aug 11;71(3):488-97
references.pmid: 21835345
references.citation: J Physiol. 2005 Apr 15;564(Pt 2):541-7
references.pmid: 15695242
references.citation: BMC Genomics. 2006 Jun 20;7:159
references.pmid: 16787531
references.citation: Nat Rev Drug Discov. 2011 Aug 01;10(8):601-20
references.pmid: 21804597
references.citation: Eur J Pharmacol. 2010 Oct 10;644(1-3):61-6
references.pmid: 20637192
references.citation: J Mol Cell Biol. 2012 Apr;4(2):88-96
references.pmid: 22241835
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3408-13
references.pmid: 19211797
references.citation: Am J Physiol. 1992 Apr;262(4 Pt 2):R568-73
references.pmid: 1314515
references.citation: J Physiol Paris. 1999 Nov;93(5):455-60
references.pmid: 10674924
references.citation: Circ Res. 2007 Apr 13;100(7):1063-70
references.pmid: 17347480
references.citation: Physiol Behav. 2009 Jan 8;96(1):149-54
references.pmid: 18938188
references.citation: J Neurosci. 2005 Dec 7;25(49):11322-9
references.pmid: 16339027
references.citation: Biochem Biophys Res Commun. 1987 Jan 15;142(1):259-64
references.pmid: 3814133
references.citation: Neuron. 2004 Mar 25;41(6):849-57
references.pmid: 15046718
references.citation: Aging (Albany NY). 2011 Apr;3(4):450-4
references.pmid: 21483038
references.citation: Int J Obes (Lond). 2007 Jan;31(1):121-30
references.pmid: 16652130
references.citation: Cell. 2000 Oct 27;103(3):525-35
references.pmid: 11081638
references.citation: Br J Pharmacol. 2012 Mar;165(5):1476-86
references.pmid: 21883144
references.citation: FEBS Lett. 2008 Jun 25;582(15):2257-62
references.pmid: 18503767
references.citation: J Appl Physiol (1985). 2011 Mar;110(3):789-98
references.pmid: 21071592
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R2128-35
references.pmid: 17761510
references.citation: Neuron. 1998 Sep;21(3):531-43
references.pmid: 9768840
references.citation: Am J Clin Nutr. 2009 Jan;89(1):45-50
references.pmid: 19056576
references.citation: Am J Physiol. 1988 Jul;255(1 Pt 1):E23-7
references.pmid: 2898892
references.citation: Obes Res. 1995 Jul;3(4):337-44
references.pmid: 8521150
references.citation: Nature. 2004 Jan 15;427(6971):260-5
references.pmid: 14712238
references.citation: Br J Pharmacol. 2012 Feb;165(4):787-801
references.pmid: 21797839
references.citation: Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1494-505
references.pmid: 21430076
references.citation: Nature. 1969 Oct 18;224(5216):285-7
references.pmid: 5344615
references.citation: Cell. 2003 Feb 7;112(3):293-301
references.pmid: 12581520
references.citation: J Nutr Sci Vitaminol (Tokyo). 2012;58(1):9-13
references.pmid: 23007061
references.citation: Physiol Rev. 2007 Jan;87(1):165-217
references.pmid: 17237345
references.citation: J Neurosci. 2010 Jan 27;30(4):1560-5
references.pmid: 20107083
references.citation: Biosci Biotechnol Biochem. 2006 Dec;70(12):2824-35
references.pmid: 17151481
references.citation: J Nutr. 1986 Jul;116(7):1272-8
references.pmid: 2875141
references.citation: J Neurosci. 2007 Jul 11;27(28):7459-68
references.pmid: 17626206
references.citation: Pharmacol Rev. 2012 Oct;64(4):939-71
references.pmid: 23023032
references.citation: J Neurosci. 2012 Feb 8;32(6):2086-99
references.pmid: 22323721
references.citation: Nat Neurosci. 2008 Mar;11(3):255-61
references.pmid: 18297068
references.citation: J Neurosci. 2005 Feb 16;25(7):1674-81
references.pmid: 15716403
references.citation: Neuron. 2007 May 3;54(3):371-8
references.pmid: 17481391
references.citation: Neuron. 2007 May 3;54(3):379-86
references.pmid: 17481392
references.citation: Cell. 2012 Sep 28;151(1):96-110
references.pmid: 23021218
references.citation: Nature. 2006 Sep 21;443(7109):289-95
references.pmid: 16988703
references.citation: Physiol Behav. 2012 Aug 20;107(1):50-8
references.pmid: 22683548
references.citation: Pain. 2000 Nov;88(2):205-215
references.pmid: 11050376
references.citation: Neuron. 1992 Apr;8(4):643-51
references.pmid: 1314617
references.citation: J Physiol. 1970 Mar;206(3):495-507
references.pmid: 5498502
references.citation: Annu Rev Biochem. 2007;76:387-417
references.pmid: 17579562
references.citation: Am J Physiol Endocrinol Metab. 2012 Apr 1;302(7):E807-16
references.pmid: 22275755
references.citation: BMC Neurosci. 2007 Jul 04;8:49
references.pmid: 17610722
references.citation: Physiol Genomics. 2000 Aug 09;3(2):75-82
references.pmid: 11015602
references.citation: Int J Obes (Lond). 2005 Jun;29(6):682-8
references.pmid: 15611784
references.citation: Chem Senses. 2012 Feb;37(2):103-21
references.pmid: 22038945
references.citation: Dig Dis Sci. 1998 Jun;43(6):1165-71
references.pmid: 9635602
references.citation: Nat Neurosci. 2005 May;8(5):626-34
references.pmid: 15852009
references.citation: J Neurosci. 2011 Feb 2;31(5):1721-33
references.pmid: 21289181
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 2009 Oct;380(4):353-7
references.pmid: 19629446
references.citation: Aliment Pharmacol Ther. 2000 Jan;14(1):129-34
references.pmid: 10632656
references.citation: Eur J Hum Genet. 2005 Jan;13(1):102-8
references.pmid: 15470360
references.citation: Planta Med. 2001 Oct;67(7):628-33
references.pmid: 11582540