title: CYFRA21-1 as a serum tumor marker for follow-up patients with squamous cell lung carcinoma and oropharynx squamous cell carcinoma.
abstract: OBJECTIVE
  To evaluate serum soluble fragments of cytokeratin 19 (i.e., CYFRA21-1) as a tumor marker for patients with squamous cell lung carcinoma (SCLC) and oropharynx squamous cell carcinoma (OSCC).
  
  
  METHODS
  A total of 152 patients with SCLC and OSCC, and 84 control patients were included in the study. CYFRA21-1 concentration was measured using electrochemiluminescence immunoassays.
  
  
  RESULTS
  As the disease stages increased, concentrations and sensitivity of CYFRA21-1 increased significantly in patients with SCLC and OSCC. A significant difference in sensitivity between the pretherapeutic group and recurrence group of OSCC (p = 0.001) was observed, as well as for SCLC (p = 0.024). A positive correlation (p = 0.042) existed between CYFRA21-1 concentrations and cancer stage of SCLC and OSCC. There was no significant correlation between CYFRA21-1 concentrations and different organ types with squamous cell cancer (p = 0.51).
  
  
  CONCLUSIONS
  The CYFRA21-1 assay demonstrated a greater sensitivity for recurrent stages of SCLC and OSCC, and may prove beneficial in the prediction of SCLC and OSCC recurrence at an earlier date.
authors.affiliation: Department of Respiratory Medicine, the Fourth Affiliated Hospital of Harbin Medical University, No 37, Yi Yuan Street, Nan Gang District, Harbin 150001, China. liulei110052@163.com
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhu
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053539:Keratin-19 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018307:Neoplasms, Squamous Cell / Q000097:blood* / Q000473:pathology; D009959:Oropharyngeal Neoplasms / Q000097:blood* / Q000473:pathology; D012372:ROC Curve; D055815:Young Adult
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053539:Keratin-19; C102012:antigen CYFRA21.1