title: Insights into the prognostic value of DJ-1 and MIB-1 in astrocytic tumors.
abstract: BACKGROUND
  The histological grade is the gold standard for the evaluation of prognosis of astrocytic tumors. Nevertheless, morphologic criteria are not always accurate prognostic indicators.
  
  
  OBJECTIVE
  The research investigates the expression of MIB-1 and DJ-1 in different grades of astrocytomas and evaluates the possible prognostic role of DJ-1 in these tumors in relation to other prognostic parameters including the MIB-1 labeling index.
  
  
  METHODS
  Immunohistochemical expression of MIB-1 and DJ-1 was evaluated in 111 samples of astrocytic tumors comprising 28 diffuse astrocytomas, 38 anaplastic astrocytomas and 45 glioblastomas. The univariate survival analysis was done using the Kaplan-Meier method and the multivariate survival analysis was done using Cox proportional hazard model.
  
  
  RESULTS
  The statistical analysis revealed a significant correlation between each of DJ-1 and MIB-1 and the histological grade of astrocytomas. The univariate analysis showed that high grade, high DJ-1 score and MIB-1 labeling index ≥ 10.1 were associated with poor survival. Multivariate analysis for all the studied astrocytomas proved the independent prognostic significance of the histological grade and DJ-1 score. Meanwhile, the multivariate analysis for each grade emphasized that DJ-1 was the only independent prognostic indicator in high-grade astrocytomas.
  
  
  CONCLUSIONS
  This study emphasized the effectiveness of high DJ-1 expression in predicting poor survival of astrocytoma patients, when compared to MIB-1. DJ-1 could be particularly important in cases with discrepancies between the morphologic criteria and clinical parameters.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1070116023943146.
authors.affiliation: Department of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. rashashaban9000@yahoo.com.
authors.forename: Rasha M
authors.initials: RM
authors.lastname: Abd El Atti
authors.forename: Hoda H
authors.initials: HH
authors.lastname: Abou Gabal
authors.forename: Wesam M
authors.initials: WM
authors.lastname: Osman
authors.forename: Amr S
authors.initials: AS
authors.lastname: Saad
mesh_terms: D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis*; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D015513:Oncogene Proteins / Q000032:analysis*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D000071617:Protein Deglycase DJ-1; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; D019394:Ki-67 Antigen; C440408:MIB-1 antibody; D015513:Oncogene Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1
references.citation: Arch Pathol Lab Med. 1998 Jul;122(7):609-19
references.pmid: 9674542
references.citation: Neuropathology. 2009 Apr;29(2):125-31
references.pmid: 18647263
references.citation: Indian J Pathol Microbiol. 2011 Jul-Sep;54(3):520-5
references.pmid: 21934213
references.citation: Neuropathology. 2011 Feb;31(1):29-37
references.pmid: 20497343
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9691-6
references.pmid: 15983381
references.citation: Hum Pathol. 2008 Jan;39(1):87-95
references.pmid: 17949781
references.citation: Neurosurgery. 1994 Apr;34(4):674-8; discussion 678-9
references.pmid: 8008166
references.citation: Indian J Pathol Microbiol. 2007 Oct;50(4):754-8
references.pmid: 18306542
references.citation: Cancer. 1996 Jan 15;77(2):373-80
references.pmid: 8625247
references.citation: Diagn Pathol. 2013 Apr 24;8:67
references.pmid: 23618321
references.citation: Pathol Oncol Res. 2006;12(3):143-7
references.pmid: 16998593
references.citation: Arch Pathol Lab Med. 2008 Jun;132(6):993-1007
references.pmid: 18517285
references.citation: J Neuropathol Exp Neurol. 1999 Jan;58(1):46-53
references.pmid: 10068313
references.citation: Clin Cancer Res. 2001 Nov;7(11):3328-35
references.pmid: 11705844
references.citation: J Biol Chem. 2008 Feb 15;283(7):4022-30
references.pmid: 18042550
references.citation: J Clin Pathol. 2002 Jun;55(6):467-71
references.pmid: 12037032
references.citation: Arch Pathol Lab Med. 2000 Jan;124(1):108-13
references.pmid: 10629140
references.citation: Diagn Pathol. 2011 May 24;6:43
references.pmid: 21609421
references.citation: BMC Cancer. 2008 Aug 16;8:241
references.pmid: 18706098
references.citation: J Neurooncol. 1996 Jan;27(1):65-73
references.pmid: 8699228
references.citation: Clin Neuropathol. 2004 Nov-Dec;23(6):262-70
references.pmid: 15584210
references.citation: Diagn Pathol. 2010 Mar 23;5:18
references.pmid: 20331873
references.citation: J Neurochem. 2008 Jun 1;105(6):2435-53
references.pmid: 18331584
references.citation: Anticancer Res. 2010 Jan;30(1):265-9
references.pmid: 20150646
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3593-602
references.pmid: 19064576
references.citation: J Neurosurg Sci. 2000 Dec;44(4):203-9; discussion 209-10
references.pmid: 11327289
references.citation: J Neurol Neurosurg Psychiatry. 1995 Oct;59(4):413-9
references.pmid: 7561922
references.citation: J Neurooncol. 2002 Jul;58(3):203-15
references.pmid: 12187956
references.citation: Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15091-6
references.pmid: 17015834
references.citation: Cancer. 1998 Jun 15;82(12):2459-66
references.pmid: 9635540
references.citation: J Neuropathol Exp Neurol. 1997 Aug;56(8):857-65
references.pmid: 9258255
references.citation: J Neurooncol. 2006 Jan;76(2):193-200
references.pmid: 16234986
references.citation: Neurochirurgie. 1998 Mar;44(1):25-30
references.pmid: 9757314
references.citation: Brain. 2004 Feb;127(Pt 2):420-30
references.pmid: 14662519
references.citation: Diagn Pathol. 2012 Jan 20;7:8
references.pmid: 22264301
references.citation: J Neuropathol Exp Neurol. 1998 Oct;57(10):931-6
references.pmid: 9786243
references.citation: J Neuropathol Exp Neurol. 1997 Jul;56(7):798-805
references.pmid: 9210876
references.citation: J Neurosci Res. 2009 Jan;87(1):123-9
references.pmid: 18711745
references.citation: Br J Cancer. 1992 Aug;66(2):373-85
references.pmid: 1503912