title: [Clinical analysis of nasal and laryngeal neuroendocrine carcinoma].
abstract: OBJECTIVE
  To investigate the clinicopathological features, therapeutic methods and therapeutic effects of neuroendocrine carcinoma in nasal and laryngeal region.
  
  
  METHODS
  Six cases with neuroendocrine carcinoma of the nose and the larynx were analyzed retrospectively. All cases were proved by pathology and immunohistochemistry. One case was treated by only radiotherapy, and five cases by combined treatment (surgery followed by radiotherapy and chemotherapy).
  
  
  RESULTS
  All the patients were followed up for a period of 11-84 months. Two cases showed recurrence after operation. Three cases occurred cervical lymph node metastasis, of which 2 cases received neck dissection and 1 case received chemotherapy and radiotherapy due to no surgical indications. Three cases occurred local recurrence, cervical lymphadenopathy, liver or lung metastases. Until the last follow up, four patients died of tumor, while two patients lived with no evidence of disease.
  
  
  CONCLUSIONS
  Nasal and laryngeal neuroendocrine carcinoma is composed of a group of different morphology and prognosis lesions. Corrent diagnosis depends on clinical characteristic, electron microscopic and immunohistochemical examination. CT and MRI examination could be helpful to understand the extent of disease and lesion nature. The prognosis and treatment method of neuroendocrine carcinoma were vary with different pathological types. Combined treatment based on surgery should be adopted to the disease.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Sichuan Provincial People's Hospital, Chengdu, 610072, China.
authors.forename: Qingjia
authors.initials: Q
authors.lastname: Gu
authors.forename: Jingxian
authors.initials: J
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Feng
authors.forename: Jiangang
authors.initials: J
authors.lastname: Fan
authors.forename: Gang
authors.initials: G
authors.lastname: He
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Shuihong
authors.initials: S
authors.lastname: Zhou
authors.forename: Shenqing
authors.initials: S
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D018278:Carcinoma, Neuroendocrine; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms; D012189:Retrospective Studies