title: KOtBu-mediated stereoselective addition of quinazolines to alkynes under mild conditions.
abstract: A facile alkenylation of quinazolines with unactivated terminal alkynes has been achieved in the presence of KOtBu without the aid of any transition metal catalysts. The reaction is carried out under very mild conditions and shows a high stereoselectivity. A possible radical-based mechanism is also explored.
authors.affiliation: State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China. lijxnju@nju.edu.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Qi
authors.initials: Q
authors.lastname: Shen
authors.forename: Yu-Ren
authors.initials: YR
authors.lastname: Zhou
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Li