title: Contribution and regulation of TRPC channels in store-operated Ca2+ entry.
abstract: Store-operated calcium entry (SOCE) is activated in response to depletion of the endoplasmic reticulum-Ca(2+) stores following stimulation of plasma membrane receptors that couple to PIP2 hydrolysis and IP3 generation. Search for the molecular components of SOCE channels led to the identification of mammalian transient receptor potential canonical (TRPC) family of calcium-permeable channels (TRPC1-TRPC7), which are all activated in response to stimuli that result in PIP2 hydrolysis. While several TRPCs, including TRPC1, TRPC3, and TRPC4, have been implicated in SOCE, the data are most consistent for TRPC1. Extensive studies in cell lines and knockout mouse models have established the contribution of TRPC1 to SOCE. Furthermore, there is a critical functional interaction between TRPC1 and the key components of SOCE, STIM1, and Orai1, which determines the activation of TRPC1. Orai1-mediated Ca(2+) entry is required for recruitment of TRPC1 and its insertion into surface membranes while STIM1 gates the channel. Notably, TRPC1 and Orai1 generate distinct patterns of Ca(2+) signals in cells that are decoded for the regulation of specific cellular functions. Thus, SOCE appears to be a complex process that depends on temporal and spatial coordination of several distinct steps mediated by proteins in different cellular compartments. Emerging data suggest that, in many cell types, the net Ca(2+) entry measured in response to store depletion is the result of the coordinated regulation of different calcium-permeable ion channels. Orai1 and STIM1 are central players in this process, and by mediating recruitment or activation of other Ca(2+) channels, Orai1-CRAC function can elicit rapid changes in global and local [Ca(2+)]i signals in cells. It is most likely that the type of channels and the [Ca(2+)]i signature that are generated by this process reflect the physiological function of the cell that is regulated by Ca(2+).
authors.affiliation: Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Kwong Tai
authors.initials: KT
authors.lastname: Cheng
authors.forename: Hwei Ling
authors.initials: HL
authors.lastname: Ong
authors.forename: Xibao
authors.initials: X
authors.lastname: Liu
authors.forename: Indu S
authors.initials: IS
authors.lastname: Ambudkar
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D000071740:ORAI1 Protein; D055503:Protein Multimerization; D000071737:Stromal Interaction Molecule 1; D050052:TRPC Cation Channels / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C103530:STIM1 protein, human; D000071737:Stromal Interaction Molecule 1; D050052:TRPC Cation Channels; C096351:transient receptor potential cation channel, subfamily C, member 1
keywords: Ca(2+) signaling; Cell function; Orai1; SOCE; STIM1; TRPC channels; TRPC1
references.citation: J Appl Physiol (1985). 2002 Apr;92(4):1594-602
references.pmid: 11896026
references.citation: J Immunol. 2008 Feb 15;180(4):2233-9
references.pmid: 18250430
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3202-6
references.pmid: 19221033
references.citation: Biochimie. 2013 Feb;95(2):347-53
references.pmid: 23079337
references.citation: PLoS Biol. 2011 Mar;9(3):e1001025
references.pmid: 21408196
references.citation: J Biol Chem. 2003 Oct 3;278(40):39014-9
references.pmid: 12857742
references.citation: Physiol Rev. 2005 Apr;85(2):757-810
references.pmid: 15788710
references.citation: Exp Biol Med (Maywood). 2009 Jun;234(6):673-82
references.pmid: 19307462
references.citation: Am J Physiol Cell Physiol. 2010 Jan;298(1):C149-62
references.pmid: 19846750
references.citation: Nat Rev Immunol. 2007 Oct;7(10):778-89
references.pmid: 17853903
references.citation: J Gen Physiol. 2009 May;133(5):525-46
references.pmid: 19398778
references.citation: Cell Calcium. 2013 May-Jun;53(5-6):315-26
references.pmid: 23489970
references.citation: Cell Calcium. 2007 Aug;42(2):205-11
references.pmid: 17517433
references.citation: Annu Rev Physiol. 2006;68:685-717
references.pmid: 16460288
references.citation: Hum Mol Genet. 2009 Apr 1;18(7):1238-51
references.pmid: 19193631
references.citation: Circ Res. 2009 Nov 6;105(10):1023-30
references.pmid: 19797170
references.citation: Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H746-55
references.pmid: 11158974
references.citation: Nat Cell Biol. 2001 Feb;3(2):121-7
references.pmid: 11175743
references.citation: J Mol Endocrinol. 2010 May;44(5):285-94
references.pmid: 20194530
references.citation: J Biol Chem. 2005 Jun 3;280(22):21600-6
references.pmid: 15834157
references.citation: J Biol Chem. 2003 Aug 29;278(35):33492-500
references.pmid: 12766172
references.citation: J Biol Chem. 2004 May 14;279(20):20941-9
references.pmid: 15016832
references.citation: Nat Rev Mol Cell Biol. 2012 Sep;13(9):549-65
references.pmid: 22914293
references.citation: Science. 2012 Dec 7;338(6112):1308-13
references.pmid: 23180775
references.citation: Biochim Biophys Acta. 2011 Dec;1808(12):2789-97
references.pmid: 21871867
references.citation: J Biol Chem. 2010 Dec 3;285(49):38666-73
references.pmid: 20926378
references.citation: Proc Natl Acad Sci U S A. 2002 May 28;99(11):7461-6
references.pmid: 12032305
references.citation: J Membr Biol. 2004 Jul 15;200(2):93-104
references.pmid: 15520907
references.citation: Science. 2010 Oct 1;330(6000):101-5
references.pmid: 20929812
references.citation: Channels (Austin). 2011 Sep-Oct;5(5):424-31
references.pmid: 21747233
references.citation: Circ Res. 2012 May 25;110(11):1435-44
references.pmid: 22534489
references.citation: Mol Pharmacol. 2012 Apr;81(4):510-26
references.pmid: 22210847
references.citation: J Cell Biol. 2010 Nov 1;191(3):523-35
references.pmid: 21041445
references.citation: J Biol Chem. 2008 Jun 20;283(25):17333-40
references.pmid: 18430726
references.citation: J Biol Chem. 2004 Oct 15;279(42):43392-402
references.pmid: 15297455
references.citation: Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G782-92
references.pmid: 16282360
references.citation: Gastroenterology. 2009 Oct;137(4):1509-17
references.pmid: 19622358
references.citation: J Biol Chem. 2000 Aug 4;275(31):23965-72
references.pmid: 10816590
references.citation: Nature. 2006 May 11;441(7090):179-85
references.pmid: 16582901
references.citation: PLoS One. 2012;7(10):e47146
references.pmid: 23115638
references.citation: Science. 2006 May 26;312(5777):1220-3
references.pmid: 16645049
references.citation: Amino Acids. 2010 Jun;39(1):195-204
references.pmid: 19997763
references.citation: Microcirculation. 2006 Dec;13(8):693-708
references.pmid: 17085428
references.citation: Biochem Pharmacol. 2011 Aug 15;82(4):400-10
references.pmid: 21640715
references.citation: Neuron. 2001 Mar;29(3):645-55
references.pmid: 11301024
references.citation: J Cell Biol. 2002 Sep 16;158(6):1089-96
references.pmid: 12235126
references.citation: Clin Exp Pharmacol Physiol. 2005 Aug;32(8):597-603
references.pmid: 16120184
references.citation: J Biol Chem. 2006 Oct 27;281(43):32540-9
references.pmid: 16887806
references.citation: J Vasc Res. 2013;50(1):11-20
references.pmid: 23095462
references.citation: Physiol Rev. 1997 Oct;77(4):901-30
references.pmid: 9354808
references.citation: Immunol Rev. 2009 Sep;231(1):189-209
references.pmid: 19754898
references.citation: Pflugers Arch. 2006 Apr;452(1):43-52
references.pmid: 16283206
references.citation: Traffic. 2011 Feb;12(2):232-45
references.pmid: 21054717
references.citation: J Hypertens. 2007 Apr;25(4):799-808
references.pmid: 17351372
references.citation: Semin Immunol. 1990 Mar;2(2):107-17
references.pmid: 1717052
references.citation: J Cell Physiol. 2008 Jul;216(1):162-71
references.pmid: 18247362
references.citation: Nat Cell Biol. 2007 Jun;9(6):636-45
references.pmid: 17486119
references.citation: J Biol Chem. 2000 Apr 21;275(16):11934-42
references.pmid: 10766822
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20087-92
references.pmid: 19897728
references.citation: Neuron. 2008 Aug 14;59(3):392-8
references.pmid: 18701065
references.citation: Circ Res. 2002 Jul 12;91(1):70-6
references.pmid: 12114324
references.citation: J Biol Chem. 2001 Mar 16;276(11):7782-90
references.pmid: 11113149
references.citation: Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2060-4
references.pmid: 10051594
references.citation: J Biol Chem. 2007 Mar 23;282(12):9105-16
references.pmid: 17224452
references.citation: J Biol Chem. 2002 Dec 13;277(50):48303-10
references.pmid: 12377790
references.citation: J Exp Med. 2002 Mar 18;195(6):673-81
references.pmid: 11901194
references.citation: J Cell Biol. 2005 May 9;169(3):435-45
references.pmid: 15866891
references.citation: Annu Rev Immunol. 2010;28:491-533
references.pmid: 20307213
references.citation: J Biol Chem. 2009 Dec 4;284(49):34423-32
references.pmid: 19815560
references.citation: Cell Calcium. 2007 Aug;42(2):213-23
references.pmid: 17350680
references.citation: Proc Natl Acad Sci U S A. 2012 May 29;109(22):8682-7
references.pmid: 22586105
references.citation: Immunol Rev. 2009 Sep;231(1):88-98
references.pmid: 19754891
references.citation: Cell Calcium. 2012 Jan;51(1):12-21
references.pmid: 22050845
references.citation: Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1303-13
references.pmid: 15347566
references.citation: J Physiol. 2004 May 1;556(Pt 3):805-17
references.pmid: 14966303
references.citation: Curr Biol. 2005 Jul 12;15(13):1235-41
references.pmid: 16005298
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2895-900
references.pmid: 18287061
references.citation: Nat Cell Biol. 2006 Sep;8(9):1003-10
references.pmid: 16906149
references.citation: Acta Physiol (Oxf). 2012 Feb;204(2):238-47
references.pmid: 21518270
references.citation: Pflugers Arch. 2007 Dec;455(3):465-77
references.pmid: 17647013
references.citation: Mol Pharmacol. 2006 Oct;70(4):1174-83
references.pmid: 16822931
references.citation: Adv Exp Med Biol. 2012;740:383-410
references.pmid: 22453951
references.citation: J Physiol. 1993 Jun;465:359-86
references.pmid: 8229840
references.citation: Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29
references.pmid: 12838335
references.citation: Cell Calcium. 2009 Jun;45(6):625-33
references.pmid: 19324409
references.citation: J Biol Chem. 2008 May 9;283(19):12935-40
references.pmid: 18326500
references.citation: Trends Biochem Sci. 2011 Feb;36(2):78-87
references.pmid: 20810284
references.citation: J Neurosci. 2005 Mar 9;25(10):2687-701
references.pmid: 15758179
references.citation: Nat Cell Biol. 2009 Mar;11(3):337-43
references.pmid: 19182790
references.citation: Pflugers Arch. 2005 Oct;451(1):72-80
references.pmid: 15971081
references.citation: J Biol Chem. 2005 Aug 19;280(33):29559-69
references.pmid: 15972814
references.citation: Biochem Biophys Res Commun. 2004 Oct 1;322(4):1352-8
references.pmid: 15336983
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17542-7
references.pmid: 17956991
references.citation: Mol Cell. 2002 Apr;9(4):739-50
references.pmid: 11983166
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4682-7
references.pmid: 17360584
references.citation: Cell Calcium. 2006 Nov-Dec;40(5-6):495-504
references.pmid: 17030060
references.citation: Mol Cell. 2008 Nov 7;32(3):439-48
references.pmid: 18995841
references.citation: J Biol Chem. 2009 Apr 10;284(15):9733-41
references.pmid: 19228695
references.citation: Annu Rev Biochem. 2007;76:387-417
references.pmid: 17579562
references.citation: Pharmacol Ther. 2006 Dec;112(3):744-60
references.pmid: 16842858
references.citation: J Biol Chem. 2000 Feb 4;275(5):3403-11
references.pmid: 10652333
references.citation: J Physiol. 2009 Jun 1;587(Pt 11):2429-42
references.pmid: 19332490
references.citation: Science. 2010 Oct 1;330(6000):105-9
references.pmid: 20929813
references.citation: Pflugers Arch. 2008 Nov;457(2):377-87
references.pmid: 18546016
references.citation: Biochem J. 2009 May 13;420(2):267-76
references.pmid: 19260825
references.citation: J Biol Chem. 2003 Mar 28;278(13):11337-43
references.pmid: 12536150
references.citation: Proc Natl Acad Sci U S A. 2007 May 29;104(22):9301-6
references.pmid: 17517596