title: [Role of androgen in the elderly. Dementia and androgen].
abstract: It has been shown that age-related decline in androgen secretion is associated with cognitive impairment and the risk of dementia. Epidemiological studies using community-dwelling older people and observational studies enrolling subjects with cognitive impairment have demonstrated that older men with lower androgen levels have lower cognitive function and are likely to develop dementia. In contrast, the efficacy of androgen replacement therapy on cognitive function or dementia remains to be addressed, although some preliminary studies have reported positive effects on cognitive function. Randomized controlled trials and mechanistic clarification are required in the future.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Akishita
mesh_terms: D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000378:metabolism; D000728:Androgens / Q000378:metabolism*; D003072:Cognition Disorders / Q000378:metabolism*; D003704:Dementia / Q000378:metabolism*; D006801:Humans
chemical_list: D000728:Androgens