title: Tumor necrosis factor-α 238 G/A polymorphism and gastric cancer risk: a meta-analysis.
abstract: Though many studies were performed to assess the association between tumor necrosis factor-α (TNF-α) 238 G/A polymorphism and gastric cancer risk, there were no conclusive findings. A meta-analysis of previous published studies was performed to get a comprehensive assessment of the association between TNF-α 238 G/A polymorphisms and gastric cancer. The pooled odds ratios (ORs) and 95% confidence intervals (95 % CIs) were calculated to assess the association. Fifteen studies with a total of 7,795 participants were finally included into this meta-analysis. Overall, there was an obvious association between TNF-α 238 G/A polymorphism and increased risk of gastric cancer (A vs. G: OR = 1.32, 95% CI 1.02-1.72, P = 0.036; GA vs. GG: OR = 1.32, 95% CI 1.01-1.72, P = 0.042; and AA/GA vs. GG: OR = 1.34, 95% CI 1.02-1.76, P = 0.036). Subgroup analysis by ethnicity showed the statistically significant association between TNF-α 238 G/A polymorphism and gastric cancer was limited to Asian populations (A vs. G: OR = 1.59, 95% CI 1.29-1.97, P < 0.001; GA vs. GG: OR = 1.63, 95% CI 1.29-2.04, P < 0.001; and AA/GA vs. GG: OR = 1.64, 95%CI 1.31-2.05, P < 0.001), and there was no obvious association in Caucasians. In conclusion, TNF-α 238 G/A polymorphism is significantly associated with increased risk of gastric cancer, especially in Asians.
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Cancer Hospital, Jinan, 250117, China.
authors.forename: Jian-yong
authors.initials: JY
authors.lastname: Yu
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Heng
authors.initials: H
authors.lastname: Ma
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Xurui
authors.initials: X
authors.lastname: Cheng
authors.forename: Yan-liang
authors.initials: YL
authors.lastname: Li
authors.forename: Xi-lin
authors.initials: XL
authors.lastname: Song
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha
references.citation: Br J Cancer. 2008 Apr 22;98(8):1443-51
references.pmid: 18319718
references.citation: Gastroenterol Clin North Am. 2013 Jun;42(2):285-98
references.pmid: 23639641
references.citation: Carcinogenesis. 2007 Jan;28(1):118-23
references.pmid: 16885196
references.citation: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references.pmid: 21296855
references.citation: Zhonghua Yi Xue Za Zhi. 2007 Apr 17;87(15):1037-9
references.pmid: 17672967
references.citation: Lancet Oncol. 2013 May;14(6):e218-28
references.pmid: 23639322
references.citation: Carcinogenesis. 2005 Mar;26(3):631-6
references.pmid: 15579481
references.citation: Am J Gastroenterol. 2007 Sep;102(9):1878-92
references.pmid: 17640324
references.citation: Annu Rev Immunol. 2005;23:23-68
references.pmid: 15771565
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: Tumour Biol. 2013 Jun;34(3):1659-65
references.pmid: 23494178
references.citation: Cancer Causes Control. 2006 Feb;17(1):117-25
references.pmid: 16411061
references.citation: Nat Rev Cancer. 2010 Jun;10(6):403-14
references.pmid: 20495574
references.citation: Cancer Lett. 2013 Jan 28;328(2):222-5
references.pmid: 23085193
references.citation: Cancer Lett. 2001 May 10;166(1):41-6
references.pmid: 11295285
references.citation: J Cell Biochem. 2013 Mar;114(3):491-7
references.pmid: 22961880
references.citation: BMC Cancer. 2009 Jul 17;9:238
references.pmid: 19615068
references.citation: Curr Pharm Des. 2012;18(26):3831-52
references.pmid: 22632748
references.citation: Gastroenterology. 2005 May;128(6):1567-78
references.pmid: 15887152
references.citation: Cytokine. 2005 Feb 21;29(4):141-52
references.pmid: 15652446
references.citation: Ann Oncol. 2008 Nov;19(11):1894-902
references.pmid: 18628242
references.citation: Cytokine. 2004 Oct 21;28(2):75-82
references.pmid: 15381184
references.citation: Int J Cancer. 2003 May 1;104(5):617-23
references.pmid: 12594817
references.citation: Breast Cancer Res Treat. 2011 Apr;126(3):763-70
references.pmid: 20882404
references.citation: Am J Epidemiol. 2011 Feb 1;173(3):259-70
references.pmid: 21178102
references.citation: Int J Cancer. 2004 Jul 10;110(5):695-700
references.pmid: 15146559
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120