title: Host signal transduction and protein kinases implicated in Legionella infection.
abstract: Modulation of the phosphorylation status of proteins by both kinases and phosphatases plays an important role in cellular signal transduction. Challenge of host cells by Legionella pneumophila manipulates the phosphorylation state of multiple host factors. These changes play roles in bacterial uptake, vacuole modification, cellular survival, and the immune response. In addition to modification by host cell kinases in response to the bacterium, L. pneumophila translocates bacterial kinases into the host cell that may contribute to further signaling modifications. Proper regulation of host cell signaling by L. pneumophila is necessary for its ability to replicate intracellulary, while avoiding host defenses.
authors.affiliation: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, 02111, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hempstead
authors.forename: Ralph R
authors.initials: RR
authors.lastname: Isberg
mesh_terms: D006801:Humans; D016952:Legionella pneumophila / Q000472:pathogenicity*; D020935:MAP Kinase Signaling System / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D016328:NF-kappa B; D011494:Protein Kinases; D011493:Protein Kinase C
references.citation: Mol Microbiol. 1993 Jan;7(1):7-19
references.pmid: 8382332
references.citation: Genes Dev. 2012 Feb 1;26(3):203-34
references.pmid: 22302935
references.citation: Science. 2012 Dec 14;338(6113):1440-4
references.pmid: 23239729
references.citation: Cytokine. 2009 Dec;48(3):161-9
references.pmid: 19740675
references.citation: Crit Rev Eukaryot Gene Expr. 2001;11(1-3):243-67
references.pmid: 11693964
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13725-30
references.pmid: 19666608
references.citation: PLoS Pathog. 2009 Jul;5(7):e1000501
references.pmid: 19578436
references.citation: Mol Microbiol. 1999 Jun;32(5):990-1001
references.pmid: 10361301
references.citation: Science. 1998 May 1;280(5364):734-7
references.pmid: 9563949
references.citation: Cell Mol Life Sci. 2013 Sep;70(17):3057-66
references.pmid: 23096778
references.citation: Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000224
references.pmid: 20066094
references.citation: PLoS Pathog. 2008 Aug 01;4(8):e1000117
references.pmid: 18670632
references.citation: PLoS One. 2011 Mar 09;6(3):e17638
references.pmid: 21408005
references.citation: Mol Cell Biol. 1994 Oct;14(10):6996-7012
references.pmid: 7935416
references.citation: Biochem J. 2009 Mar 15;418(3):475-89
references.pmid: 19228121
references.citation: PLoS Pathog. 2008 Nov;4(11):e1000220
references.pmid: 19043549
references.citation: PLoS Pathog. 2012 Feb;8(2):e1002546
references.pmid: 22383880
references.citation: Proc Natl Acad Sci U S A. 1988 Jun;85(11):3753-7
references.pmid: 3287375
references.citation: Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L267-77
references.pmid: 17012371
references.citation: Nature. 2002 Mar 14;416(6877):194-9
references.pmid: 11894098
references.citation: Pharmacol Ther. 2002 Feb-Mar;93(2-3):307-17
references.pmid: 12191622
references.citation: J Leukoc Biol. 2002 Dec;72(6):1092-108
references.pmid: 12488490
references.citation: Cell Microbiol. 2010 Aug;12(8):1083-97
references.pmid: 20148897
references.citation: PLoS One. 2008 Oct 02;3(10):e3324
references.pmid: 18830409
references.citation: J Immunol. 1999 Nov 15;163(10):5505-11
references.pmid: 10553077
references.citation: Eur J Biochem. 2001 Oct;268(19):5001-10
references.pmid: 11589691
references.citation: Mol Microbiol. 2000 Nov;38(4):719-36
references.pmid: 11115108
references.citation: J Cell Biol. 1995 Feb;128(3):405-13
references.pmid: 7844154
references.citation: J Exp Med. 1996 Dec 1;184(6):2399-404
references.pmid: 8976194
references.citation: Science. 2007 Feb 16;315(5814):1000-3
references.pmid: 17303758
references.citation: Science. 2002 Dec 6;298(5600):1911-2
references.pmid: 12471242
references.citation: Infect Immun. 2001 Aug;69(8):5157-61
references.pmid: 11447198
references.citation: J Exp Med. 1997 Aug 18;186(4):537-47
references.pmid: 9254652
references.citation: J Mol Biol. 1999 Dec 17;294(5):1351-62
references.pmid: 10600390
references.citation: PLoS Pathog. 2011 Feb;7(2):e1001289
references.pmid: 21390206
references.citation: Cell Microbiol. 2011 Feb;13(2):227-45
references.pmid: 20880356
references.citation: Science. 1990 Aug 3;249(4968):553-6
references.pmid: 2166336
references.citation: Mol Microbiol. 2005 Feb;55(3):912-26
references.pmid: 15661013
references.citation: PLoS Pathog. 2007 Dec;3(12):e188
references.pmid: 18069892
references.citation: Nature. 2002 Mar 14;416(6877):190-4
references.pmid: 11894097
references.citation: Trends Microbiol. 1996 Jul;4(7):286-90
references.pmid: 8829338
references.citation: Immunity. 1998 Mar;8(3):297-303
references.pmid: 9529147
references.citation: Infect Immun. 1998 Jun;66(6):2905-13
references.pmid: 9596766
references.citation: Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18745-50
references.pmid: 17124169
references.citation: J Exp Med. 1998 Aug 3;188(3):505-14
references.pmid: 9687528
references.citation: Biochem J. 2003 Dec 15;376(Pt 3):545-52
references.pmid: 14570590
references.citation: Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9607-11
references.pmid: 1409673
references.citation: Eur Respir J. 2009 Nov;34(5):1171-9
references.pmid: 19324950
references.citation: Mol Microbiol. 2005 Apr;56(1):90-103
references.pmid: 15773981
references.citation: Immunology. 1996 Oct;89(2):281-8
references.pmid: 8943727
references.citation: Cell Microbiol. 2009 Nov;11(11):1638-51
references.pmid: 19573161
references.citation: PLoS Pathog. 2009 Jul;5(7):e1000508
references.pmid: 19593377
references.citation: Biochem Biophys Res Commun. 1998 Jul 30;248(3):706-11
references.pmid: 9703991
references.citation: Cell Host Microbe. 2009 Sep 17;6(3):253-67
references.pmid: 19748467
references.citation: Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L687-95
references.pmid: 20154223
references.citation: Cell. 1995 Jun 2;81(5):727-36
references.pmid: 7774014
references.citation: J Biol Chem. 2004 Dec 10;279(50):51953-7
references.pmid: 15459200
references.citation: J Mol Evol. 1999 Nov;49(5):567-82
references.pmid: 10552038
references.citation: Front Microbiol. 2011 Apr 04;2:64
references.pmid: 21747787
references.citation: Microbes Infect. 2000 Jul;2(8):867-75
references.pmid: 10962269
references.citation: Infect Immun. 1999 Sep;67(9):4490-8
references.pmid: 10456891
references.citation: Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83
references.pmid: 21372320
references.citation: Nat Rev Mol Cell Biol. 2007 Jul;8(7):530-41
references.pmid: 17585314
references.citation: Front Biosci. 2000 Apr 01;5:D406-23
references.pmid: 10762593
references.citation: Science. 2002 Jan 25;295(5555):679-82
references.pmid: 11809974
references.citation: J Biol Chem. 1992 Jul 25;267(21):14955-62
references.pmid: 1321821
references.citation: J Bacteriol. 2005 Nov;187(22):7716-26
references.pmid: 16267296
references.citation: J Protozool. 1990 Nov-Dec;37(6):581-3
references.pmid: 2086787
references.citation: Enzyme Res. 2011;2011:537821
references.pmid: 21876792
references.citation: J Exp Med. 2006 Sep 4;203(9):2177-89
references.pmid: 16940169
references.citation: Infect Immun. 2012 Oct;80(10):3570-5
references.pmid: 22851749
references.citation: Trends Biochem Sci. 2002 Oct;27(10):514-20
references.pmid: 12368087
references.citation: Biochem J. 2010 Mar 15;427(1):57-67
references.pmid: 20102336
references.citation: J Biol Chem. 2001 Feb 16;276(7):4812-8
references.pmid: 11087742
references.citation: Mol Microbiol. 2008 Mar;67(6):1307-19
references.pmid: 18284575
references.citation: Infect Immun. 2004 Mar;72(3):1512-8
references.pmid: 14977957
references.citation: Nat Immunol. 2006 Dec;7(12):1250-7
references.pmid: 17110941
references.citation: Cell Microbiol. 2007 Jan;9(1):246-64
references.pmid: 16911566
references.citation: Nat Rev Immunol. 2002 Oct;2(10):725-34
references.pmid: 12360211
references.citation: Infect Immun. 2011 May;79(5):1936-50
references.pmid: 21321072
references.citation: Science. 2005 Feb 4;307(5710):731-4
references.pmid: 15692051
references.citation: EMBO Rep. 2001 Aug;2(8):736-42
references.pmid: 11463746
references.citation: Lancet. 1993 Jan 2;341(8836):17-9
references.pmid: 7678048
references.citation: J Immunol. 2000 Apr 15;164(8):4301-6
references.pmid: 10754329
references.citation: Helicobacter. 2010 Jun;15(3):163-76
references.pmid: 20557357
references.citation: Cell Mol Life Sci. 2008 Oct;65(19):2964-78
references.pmid: 18535784
references.citation: Can J Microbiol. 2012 Feb;58(2):151-7
references.pmid: 22260247
references.citation: PLoS Pathog. 2006 Apr;2(4):e34
references.pmid: 16652170
references.citation: Immunity. 2008 Feb;28(2):183-96
references.pmid: 18249142
references.citation: Semin Immunol. 2007 Feb;19(1):24-32
references.pmid: 17275323