title: Effect of eriodictyol on the development of atopic dermatitis-like lesions in ICR mice.
abstract: Atopic dermatitis (AD) is a chronic, allergic, and inflammatory skin disease associated with eczema and dermatitis symptoms. Our previous studies have reported that eriodictyol extract inhibits immunoglobulin E (IgE)/Ag-induced type I hypersensitivity by suppressing the activation of proinflammatory cytokines, such as interleukin-4 (IL-4), and the expression of ceramide kinase. In this study, we investigated the inhibitory effect of eriodictyol on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in ICR mice. Treatment with 2 mg/mL eriodictyol for DNCB-induced AD-like skin lesions in ICR mice improved scratching behavior and skin severity score. Histological analysis demonstrated that thickening of the skin lesions were significantly reduced in the eriodictyol-treated group. Also, eriodictyol suppressed the DNCB-mediated elevation of IgE serum levels. These results suggest that eriodictyol may be a potential therapeutic resource for AD and an adjunctive agent to control itchiness in AD.
authors.affiliation: Division of Biological Science and Technology, College of Science and Technology, Yonsei University, Wonju 220–710, Korea.
authors.forename: Sae-Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Yong-Hyeon
authors.initials: YH
authors.lastname: Lee
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Tack-Joong
authors.initials: TJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D003876:Dermatitis, Atopic / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004137:Dinitrochlorobenzene; D044950:Flavanones / Q000627:therapeutic use*; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011537:Pruritus / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D004137:Dinitrochlorobenzene; D044950:Flavanones; D007073:Immunoglobulin E; C007619:eriodictyol