title: ZnO nanoparticles induces cell death in malignant human T98G gliomas, KB and non-malignant HEK cells.
abstract: This paper reports the synthesis and characterization of ZnO nanoparticles prepared by soft chemical process. The nanoparticles of ZnO possess wurtzite hexagonal phase and were used for the induction of cell death in malignant human T98G gliomas, KB epithermoids and HEK normal non-malignant kidney cells. By applying ZnO nanoparticles, the cells exhibit that the nanoparticles are more efficacious on T98G cancer cells, moderately effective on KB cells and least toxic on normal human HEK cells. The results demonstrated that the treatment with ZnO nanoparticles sensitize T98G cells by increasing both the mitotic (linked to cytogenetic damage) and interphase (apoptosis) death. The ZnO nanoparticles behave as genotoxic drugs, since they induce a micronucleus formation in cells. The present study could be helpful in designing more potent anticancer agents for the therapeutic uses.
authors.affiliation: Abdul Rahman Al-Jeraisy Chair for DNA Research, Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia rwahab@ksu.edu.sa
authors.forename: Rizwan
authors.initials: R
authors.lastname: Wahab
authors.forename: Nagendra Kumar
authors.initials: NK
authors.lastname: Kaushik
authors.forename: Neha
authors.initials: N
authors.lastname: Kaushik
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Choi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Umar
authors.forename: Sourabh
authors.initials: S
authors.lastname: Dwivedi
authors.forename: Javed
authors.initials: J
authors.lastname: Musarrat
authors.forename: Abdulaziz A
authors.initials: AA
authors.lastname: Al-Khedhairy
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome; D015034:Zinc Oxide / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D015034:Zinc Oxide