title: Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen.
abstract: With millions of humans infected yearly with HCV, leading to cirrhosis and cancer, a vaccine is urgently needed. Cultured virus particles constitute the antigen in most antiviral vaccines. A study in mice demonstrated induction of neutralizing antibodies by immunization with cell-culture-derived HCV, providing new possibilities for vaccine development.
authors.affiliation: Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK-2650 Hvidovre, Denmark and Department of International Health, Immunology and Micobiology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen N., Denmark.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Gottwein
authors.forename: Jens
authors.initials: J
authors.lastname: Bukh
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology*; D005260:Female; D006526:Hepatitis C / Q000517:prevention & control*; D018937:Hepatitis C Antibodies / Q000276:immunology*; D006801:Humans; D007114:Immunization; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D018937:Hepatitis C Antibodies; D014761:Viral Hepatitis Vaccines
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