title: ¹³C cross-polarization magic-angle spinning nuclear magnetic resonance analysis of the solid drug forms with low concentration of an active ingredient-propranolol case.
abstract: Solid State NMR is a method that could be widely used for analyzing solid state forms of drugs in their original formulations. However, when the concentration of the active pharmaceutical ingredient (API) in the final drug form is low, (13)C CP MAS NMR methods using standard parameters are not efficient. An example of this situation is propranolol, an important drug from the group of beta-blockers whose concentration in the final drug form is low (below 10%). Basing on the differences in the CP kinetics and relaxation parameters for propranolol and the excipients the authors suggest the proper set of the CP MAS experimental parameters that would allow one to analyze API even in small concentrations in the solid drug formulations.
authors.affiliation: Faculty of Pharmacy, Medical University of Warsaw, Department of Physical Chemistry, Banacha 1, 02-093 Warsaw, Poland. Electronic address: dpisklak@wum.edu.pl.
authors.forename: Dariusz Maciej
authors.initials: DM
authors.lastname: Pisklak
authors.affiliation: Faculty of Pharmacy, Medical University of Warsaw, Department of Inorganic and Analytical Chemistry, Banacha 1, 02-093 Warsaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Zielińska-Pisklak
authors.affiliation: Faculty of Pharmacy, Medical University of Warsaw, Department of Physical Chemistry, Banacha 1, 02-093 Warsaw, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Szeleszczuk
authors.affiliation: Faculty of Pharmacy, Medical University of Warsaw, Department of Physical Chemistry, Banacha 1, 02-093 Warsaw, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Wawer
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D002247:Carbon Isotopes; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005079:Excipients / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011433:Propranolol / Q000737:chemistry*
chemical_list: D000319:Adrenergic beta-Antagonists; D002247:Carbon Isotopes; D005079:Excipients; D011433:Propranolol
keywords: Cross polarization; Propranolol; Solid drug forms; Solid state NMR; Tablets