title: Natural killer cell response to BK virus infection in polyoma virus-associated nephropathy of renal transplant recipients.
abstract: The mechanisms of injury and advantage secured by opportunistic infection with polyoma virus in renal transplant patients are not completely known. Patient virus-specific T cells play a large role in elimination of reactivated polyoma virus. Natural killer (NK) cells are early responders in antiviral response. Inflammatory NK-cell antiviral responses involve activation receptors such as killer-cell immunoglobulin-like receptors (KIRs) interacting with host-cell major histocompatibility complex class I molecules, altering cell sensitivity to lysis by NK cells.
authors.affiliation: Pediatrics, University, Halifax, Nova Scotia, Canada. Philip.acott@iwk.nshealth.ca
authors.forename: Philip D
authors.initials: PD
authors.lastname: Acott
mesh_terms: D001739:BK Virus / Q000472:pathogenicity*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics*; D016030:Kidney Transplantation / Q000009:adverse effects*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D027601:Polyomavirus Infections / Q000235:genetics*; D054349:Receptors, KIR3DS1 / Q000235:genetics*; D014412:Tumor Virus Infections / Q000235:genetics*
chemical_list: D054349:Receptors, KIR3DS1