title: IL-18 in inflammatory and autoimmune disease.
abstract: Inflammation serves as the first line of defense in response to tissue injury, guiding the immune system to ensure preservation of the host. The inflammatory response can be divided into a quick initial phase mediated mainly by innate immune cells including neutrophils and macrophages, followed by a late phase that is dominated by lymphocytes. Early in the new millennium, a key component of the inflammatory reaction was discovered with the identification of a number of cytosolic sensor proteins (Nod-like receptors) that assembled into a common structure, the 'inflammasome'. This structure includes an enzyme, caspase-1, which upon activation cleaves pro-forms of cytokines leading to subsequent release of active IL-1 and IL-18. This review focuses on the role of IL-18 in inflammatory responses with emphasis on autoimmune diseases.
authors.affiliation: Department of Medicine-Solna, Translational Immunology Unit, Karolinska Institutet, Karolinska University Hospital Solna, L2:04, 171 76, Stockholm, Sweden, Saikiran.Sedimbi@ki.se.
authors.forename: Saikiran K
authors.initials: SK
authors.lastname: Sedimbi
authors.forename: Thomas
authors.initials: T
authors.lastname: Hägglöf
authors.forename: Mikael C I
authors.initials: MC
authors.lastname: Karlsson
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology; D050197:Atherosclerosis / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D003876:Dermatitis, Atopic / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D036341:Intercellular Signaling Peptides and Proteins / Q000276:immunology; D020382:Interleukin-18 / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology; D011565:Psoriasis / Q000276:immunology; D053724:Receptors, Interleukin-18 / Q000276:immunology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D020382:Interleukin-18; D053724:Receptors, Interleukin-18; C118370:interleukin-18 binding protein
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