title: Multifunctional bioactive glass scaffolds coated with layers of poly(D,L-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin.
abstract: A new family of multifunctional scaffolds, incorporating selected biopolymer coatings on basic Bioglass® derived foams has been developed. The polymer coatings were investigated as carrier of vancomycin which is a suitable drug to impart antibiotic function to the scaffolds. It has been proved that coating with PLGA (poly(lactic-co-glycolic acid)) with dispersed vancomycin-loaded microgels provides a rapid delivery of drug to give antibacterial effects at the wound site and a further sustained release to aid mid to long-term healing. Furthermore, the microgels also improved the bioactivity of the scaffolds by acting as nucleation sites for the formation of HA crystals in simulated body fluid.
authors.affiliation: TECNALIA Health Division and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 20009 San Sebastián, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Olalde
authors.forename: N
authors.initials: N
authors.lastname: Garmendia
authors.forename: V
authors.initials: V
authors.lastname: Sáez-Martínez
authors.forename: N
authors.initials: N
authors.lastname: Argarate
authors.forename: P
authors.initials: P
authors.lastname: Nooeaid
authors.forename: F
authors.initials: F
authors.lastname: Morin
authors.forename: A R
authors.initials: AR
authors.lastname: Boccaccini
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D002118:Calcium / Q000032:analysis; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005782:Gels / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000737:chemistry; D010758:Phosphorus / Q000032:analysis; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D054457:Tissue Scaffolds / Q000737:chemistry*; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000178:Acrylamides; D020099:Coated Materials, Biocompatible; D005782:Gels; D008903:Minerals; C090629:N-isopropylacrylamide-acrylic acid copolymer; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D010758:Phosphorus; D019344:Lactic Acid; D014640:Vancomycin; D002118:Calcium
keywords: Bioglass®; Drug delivery; Microgel; PLGA; Scaffold; Vancomycin