title: Bridging the gap between systems biology and synthetic biology.
abstract: Systems biology is an inter-disciplinary science that studies the complex interactions and the collective behavior of a cell or an organism. Synthetic biology, as a technological subject, combines biological science and engineering, allowing the design and manipulation of a system for certain applications. Both systems and synthetic biology have played important roles in the recent development of microbial platforms for energy, materials, and environmental applications. More importantly, systems biology provides the knowledge necessary for the development of synthetic biology tools, which in turn facilitates the manipulation and understanding of complex biological systems. Thus, the combination of systems and synthetic biology has huge potential for studying and engineering microbes, especially to perform advanced tasks, such as producing biofuels. Although there have been very few studies in integrating systems and synthetic biology, existing examples have demonstrated great power in extending microbiological capabilities. This review focuses on recent efforts in microbiological genomics, transcriptomics, proteomics, and metabolomics, aiming to fill the gap between systems and synthetic biology.
authors.affiliation: Department of Energy, Environmental and Chemical Engineering, Washington University St. Louis, MO, USA.
authors.forename: Di
authors.initials: D
authors.lastname: Liu
authors.forename: Allison
authors.initials: A
authors.lastname: Hoynes-O'Connor
authors.forename: Fuzhong
authors.initials: F
authors.lastname: Zhang
keywords: cell factory; metabolic engineering; microbial engineering; synthetic biology; systems biology
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