title: High-grade squamous intraepithelial lesion could be managed conservatively in women up to 25 years: results from a retrospective cohort study.
abstract: OBJECTIVE
  The aim of this study was to compare histologic findings and clinical outcomes of women up to 25 years with a high-grade squamous intraepithelial lesion (HSIL) compared to women older than 25 years.
  
  
  METHODS
  Sixty-three women up to 25 years and 245 women older than 25 years with HSIL, diagnosed from June 1991 to September 2008, were examined and treated following the official Spanish guidelines. Colposcopic and histologic findings and needs for treatment were recorded, and patients were followed up for a minimum of 12 months.
  
  
  RESULTS
  A total of 308 patients were evaluated; 63.49% of women up to 25 years and 77.10% of women older than 25 years with HSIL had cervical intraepithelial neoplasia (CIN) 2+ histology (p = .04). Also, 74.60% of women up to 25 years and 99.24% of women older than 25 years underwent an excisional procedure (p < .001). No significant or clinical differences were found in the 1-year follow-up outcomes (82.54% vs 78.37% had normal results; p = ns).
  
  
  CONCLUSIONS
  Women up to 25 years have less CIN 2+ histologic findings and less need for conization compared to older women. Our findings support the feasibility to design an adequate protocol for these younger women, which would be less aggressive and would, consequently, minimize obstetric long-term secondary effects.
authors.affiliation: 1Obstetrics and Gynecology and 2Pathology Departments, Hospital del Mar, Barcelona, Spain.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Agramunt
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Checa
authors.forename: Mireia
authors.initials: M
authors.lastname: González-Comadrán
authors.forename: Fernando
authors.initials: F
authors.lastname: Larrazabal
authors.forename: Alèxia
authors.initials: A
authors.lastname: Arbós
authors.forename: Francesc
authors.initials: F
authors.lastname: Alameda
authors.forename: Gemma
authors.initials: G
authors.lastname: Mancebo
authors.forename: Ramon
authors.initials: R
authors.lastname: Carreras
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D003127:Colposcopy; D019092:Conization; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain; D016896:Treatment Outcome; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*