title: Treatment of hepatitis B and C through national programme--an audit.
abstract: OBJECTIVE
  To evaluate the response to treatment given on a large scale for hepatitis B and C through a nationwide programme.
  
  
  METHODS
  Records of patients who received treatment of hepatitis B and C during past 2 years through the Prime Minister's programme for the Prevention and Control of Hepatitis Viral Infection was retrieved randomly from 12 sites after taking consent from the management and the site managers. Data confidentiality was ensured. All data was photocopied and brought to the Pakistan Medical Research Centre at the Jinnah Postgraduate Medical Centre, Karachi, where it was entered and analysed. The inclusion/exclusion criteria and the followup tests that were to be done before, during and after treatment were taken from the National programme manager so that actual data could be matched with the guidelines. Data was analysed through a specially developed programme.
  
  
  RESULTS
  A total of 7752 patients received treatment at the 12 sites for hepatitis C. Adherence to inclusion/exclusion criteria or protocol was followed in 7572 (97.6%) patients. Out of 7572 patients, 3440 (45.4%) completed 6 months of interferon therapy, but the polymerase chain reaction test at the end of 6 months was available in 1686 (49%) cases. It was not detected at 6 months in 1133/1686 (67%) cases, while in 553 (33%) cases there was no response. Data for hepatitis B was collected from 8 sites. A total of 454 cases received treatment and 85 (18.72%) fulfilled the inclusion criteria. Treatment was completed by 9 (10.58%) cases, with 3 (3.52%) cases showing Hepatitis B 'e' antigen clearance and anti-HBe (antibody to hepatitis B 'e' antigen) production.
  
  
  CONCLUSIONS
  Poor followup and inadequate documentation of serological/biochemical tests were the major drawbacks in both hepatitis B and C patients, resulting in wastage of huge human and financial resources without proper planning and accountability.
authors.affiliation: Pakistan Medical Research Council, PMRC Research Centre, JPMC, Karachi.
authors.forename: Huma
authors.initials: H
authors.lastname: Qureshi
authors.forename: Bile Khalif
authors.initials: BK
authors.lastname: Mohamud
authors.forename: Syed Ejaz
authors.initials: SE
authors.lastname: Alam
authors.forename: Ambreen
authors.initials: A
authors.lastname: Arif
authors.forename: Waquaruddin
authors.initials: W
authors.lastname: Ahmed
mesh_terms: D019983:Guideline Adherence / Q000706:statistics & numerical data; D006509:Hepatitis B / Q000188:drug therapy*; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D008485:Medical Audit; D009313:National Health Programs / Q000592:standards; D010154:Pakistan; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome