title: Coenzyme Q10 and male infertility: a meta-analysis.
abstract: OBJECTIVE
  To evaluate the effect of coenzyme Q10 treatments in male infertility, specifically in these parameters: live birth and pregnancy rates, CoQ10 seminal concentration, sperm concentration, and sperm motility.
  
  
  METHODS
  Systematic review and meta-analysis in male infertility patients with CoQ10 oral treatments. Three trials were included: 149 males in CoQ10 group and 147 males in placebo group.
  
  
  RESULTS
  None of the included trials provided any data regarding live births. The results of this meta-analysis show that supplementing infertile men with CoQ10 does not increase pregnancy rates. The analysis showed, among patients receiving CoQ10 treatment, a statistically significant increase in: CoQ10 seminal concentration (RR 49.55, 95 % CI 46.44 to 52.66, I(2) = 17 %), sperm concentration (RR 5.33, 95 % CI 4.18 to 6.47, I(2) = 58 %), and sperm motility (RR 4.50, 95 % CI 3.92 to 5.08, I(2) = 0 %)
  
  
  CONCLUSIONS
  There is no evidence in the literature that CoQ10 increases either live birth or pregnancy rates, but there is a global improvement in sperm parameters. Adequately powered, robust trials of individual and combination antioxidant therapies are required to guide clinical practice.
authors.affiliation: Andrology Laboratory, CIRH. Clínica Corachan. ANACER, Eguilaz, 14, bajos, 08017, Barcelona, Spain, rlafuente@cirh.es.
authors.forename: Rafael
authors.initials: R
authors.lastname: Lafuente
authors.forename: Mireia
authors.initials: M
authors.lastname: González-Comadrán
authors.forename: Ivan
authors.initials: I
authors.lastname: Solà
authors.forename: Gemma
authors.initials: G
authors.lastname: López
authors.forename: Mario
authors.initials: M
authors.lastname: Brassesco
authors.forename: Ramón
authors.initials: R
authors.lastname: Carreras
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Checa
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy / Q000235:genetics*; D050498:Live Birth; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D018873:Pregnancy Rate; D016032:Randomized Controlled Trials as Topic; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology*; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; C024989:coenzyme Q10
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