title: Protective effect of dimethyl sulfoxide on stricture formation in corrosive esophageal burns in rats.
abstract: BACKGROUND
  The aim of this study was to investigate the effects of dimethyl sulfoxide (DMSO) on stricture formation in corrosive esophageal burns.
  
  
  METHODS
  A total of 21 male rats were divided equally into three groups. In Group 1 (burn) and Group 2 (burn + DMSO) burns were induced in the distal esophagi with a 30% NaOH solution. In Group 3 (control), a saline solution was applied to the esophageal lumen. In Group 2, DMSO was administered intraperitoneally (3 mg/kg) 15 minutes after the burn was induced and then every 24 hours for 7 days. All rats were humanely killed at the end of Day 22. Distal esophagi were harvested for analysis. The stenosis index (SI) and histopathologic damage score were evaluated in addition to malondialdehyde (MDA), myeloperoxidase (MPO), nitric oxide (NO), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) levels.
  
  
  RESULTS
  DMSO significantly decreased the levels of MDA, NO, TNF-α, and IL-6 in the rats with burned esophagi. Furthermore, the SI and histopathologic scores decreased significantly in the burn + DMSO group relative to the burn group (p < 0.05).
  
  
  CONCLUSIONS
  Our results suggest that DMSO can decrease the occurrence of stricture formation and could represent a beneficial alternative therapy for the treatment of corrosive esophagitis.
authors.affiliation: Department of Pediatric Surgery, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Kilincaslan
authors.affiliation: Department of Pediatrics, Zeynep Kamil Research and Education Hospital, Istanbul, Turkey.
authors.forename: Hande Ozgun
authors.initials: HO
authors.lastname: Karatepe
authors.affiliation: Department of Pediatric Surgery, Haseki Research and Education Hospital, Istanbul, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Sarac
authors.affiliation: Department of Pathology, Istanbul University, Institute of Oncology, Istanbul, Turkey.
authors.forename: Vakur
authors.initials: V
authors.lastname: Olgac
authors.affiliation: Department of Biochemistry, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Ahu Sarbay
authors.initials: AS
authors.lastname: Kemik
authors.affiliation: Department of Pediatrics, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Ahmet Hakan
authors.initials: AH
authors.lastname: Gedik
authors.affiliation: Department of Biostatistics, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Uysal
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000150:complications* / Q000473:pathology; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D004940:Esophageal Stenosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004947:Esophagus / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D008315:Malondialdehyde; D009195:Peroxidase; D004121:Dimethyl Sulfoxide