title: Evaluation of cardiac dyssynchrony with longitudinal strain analysis in 4-chamber cine MR imaging.
abstract: OBJECTIVE
  We investigated the clinical performance of evaluation of cardiac mechanical dyssynchrony with longitudinal strain analysis using four-chamber (4CH) cine magnetic resonance imaging (MRI).
  
  
  METHODS
  We retrospectively enrolled 73 chronic heart failure patients (41 men, 32 women; mean age, 57 years, NYHA 2, 3, and 4) who underwent a cardiac MRI in the present study. The left ventricular dyssynchrony (LVD) and interventricular dyssynchrony (IVD) indices were calculated by longitudinal strain analysis using 4 CH cine MRI. The LVD and IVD indices were compared by the Wilcoxon rank-sum test between the patients with indication for cardiac resynchronization therapy (CRT) (n = 13) and without indication for CRT (n = 60), with LGE (n = 40) and without LGE (n = 27), the CRT responders (n = 8) and non-responders (n = 6), respectively.
  
  
  RESULTS
  LVD in the patients with indication for CRT were significantly longer than those without indication for CRT (LVD: 92 ± 65 vs. 28 ± 40 ms, P<.01). LVD and IVD were significantly longer in the patients with LGE than those without LGE (LVD: 54 ± 58 vs. 21 ± 30 ms, P<.01 and IVD: 51 ± 39 vs. 23 ± 34 ms, P<.01). LVD and IVD in the CRT responders were significantly longer than the CRT non-responders (LVD: 126 ± 55 vs. 62 ± 55 ms, P<.01 and IVD: 96 ± 39 vs. 52 ± 40 ms, P<.05).
  
  
  CONCLUSIONS
  Longitudinal strain analysis with 4CH cine MRI could be useful for clinical examination in the evaluation of cardiac mechanical dyssynchrony.
authors.affiliation: Division of Radiology, Department of Medical Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-Ku Fukuoka-city, Fukuoka 812-8582, Japan; Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku Fukuoka-city, Fukuoka 812-8582, Japan. Electronic address: masateru@med.kyushu-u.ac.jp.
authors.forename: Masateru
authors.initials: M
authors.lastname: Kawakubo
authors.forename: Michinobu
authors.initials: M
authors.lastname: Nagao
authors.forename: Seiji
authors.initials: S
authors.lastname: Kumazawa
authors.forename: Akiko S
authors.initials: AS
authors.lastname: Chishaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Mukai
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
authors.forename: Junji
authors.initials: J
authors.lastname: Morishita
mesh_terms: D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013718:Tensile Strength; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*
keywords: Cardiac resynchronization therapy; Cine magnetic resonance imaging; Interventricular dyssynchrony; Left ventricular dyssynchrony; Longitudinal strain analysis