title: [Novel morphological and molecular aspects of lung cancer].
abstract: In recent years the classification of pulmonary cancer has seen a paradigm shift with respect to both morphological as well as molecular aspects. On the morphological side this includes novel criteria for tumor classification from biopsy material based on morphological and immunohistochemical aspects as well as a novel classification based on morphological patterns for pulmonary adenocarcinomas. In addition, this new classification now includes adenocarcinoma in situ as well as minimally invasive adenocarcinoma as novel entities and a variety of novel adenocarcinoma subtypes. This reclassification was accompanied and complemented by tremendous developments in the field of lung cancer genomics which paved the way for now widely established predictive molecular markers, e.g. epidermal growth factor receptor (EGFR) mutations and EML4-ALK translocations and will certainly lead to a variety of novel predictive markers not only for pulmonary adenocarcinoma but also for other pulmonary neoplasms.
authors.affiliation: Institut für Pathologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Warth
authors.forename: A
authors.initials: A
authors.lastname: Stenzinger
authors.forename: W
authors.initials: W
authors.lastname: Weichert
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000235:genetics*; D001706:Biopsy; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology; D018797:Cell Cycle Proteins / Q000235:genetics; D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins / Q000235:genetics; D066246:ErbB Receptors / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D053555:Keratin-5 / Q000235:genetics; D053553:Keratin-6 / Q000235:genetics; D053552:Keratin-7 / Q000235:genetics; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008565:Membrane Proteins / Q000235:genetics; D008869:Microtubule-Associated Proteins / Q000235:genetics; D011237:Predictive Value of Tests; D012697:Serine Endopeptidases / Q000235:genetics; D014157:Transcription Factors
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D005819:Genetic Markers; D053555:Keratin-5; D053553:Keratin-6; D053552:Keratin-7; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; C504003:TTF1 protein, human; D014157:Transcription Factors; C512478:EGFR protein, human; D066246:ErbB Receptors; C415585:EML4 protein, human; D012697:Serine Endopeptidases
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