title: [Angioimmunoblastic T cell lymphoma complicated with endocapillary proliferative glomerulonephritis].
abstract: A 30-year-old female developed fever and multiple lymphadenopathy in September 2011. Her symptoms improved with antibiotic treatment. However, she again presented with fever and multiple lymphadenopathy in December 2011. In addition, she suffered from nephrotic syndrome with severe edema. She was therefore hospitalized to undergo detailed examinations. Renal biopsy revealed endocapillary proliferative glomerulonephritis. Since her renal function deteriorated rapidly, she was given steroid pulse therapy with methylprednisolone, followed by maintenance therapy with prednisolone. After treatment, her renal function improved but multiple lymphadenopathy persisted. Biopsy of a left axillary lymph node was then performed and revealed angioimmunoblastic T-cell lymphoma (AITL). She received CHOP therapy but showed no response. Therefore, she was given ESHAP therapy. A partial response was achieved and the nephrotic syndrome also resolved completely. We report this extremely rare case of renal dysfunction due to endocapillary proliferative glomerulonephritis complicated by AITL.
authors.affiliation: Hematology, Graduate School of Medicine, Osaka City University.
authors.forename: Satoru
authors.initials: S
authors.lastname: Nanno
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Nakamae
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Kuwamura
authors.forename: Eiji
authors.initials: E
authors.lastname: Ishimura
authors.forename: Manami
authors.initials: M
authors.lastname: Sakabe
authors.forename: Akiko
authors.initials: A
authors.lastname: Inaba
authors.forename: Shiro
authors.initials: S
authors.lastname: Koh
authors.forename: Takuro
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Nishimoto
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Terada
authors.forename: Takahiko
authors.initials: T
authors.lastname: Nakane
authors.forename: Hideo
authors.initials: H
authors.lastname: Koh
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nakao
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ohsawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy / Q000379:methods; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications / Q000473:pathology / Q000628:therapy*; D016399:Lymphoma, T-Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000150:complications / Q000628:therapy*; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone