title: Immunoarchitectural patterns of germinal center antigens including LMO2 assist in the differential diagnosis of marginal zone lymphoma vs follicular lymphoma.
abstract: OBJECTIVE
  To examine the immunoarchitectural patterns of the germinal center (GC)-associated markers CD10, BCL6, and LMO2 and their utility in the differential diagnosis of marginal zone lymphoma (MZL) vs follicular lymphoma (FL).
  
  
  METHODS
  Forty-two cases of MZL involving lymph nodes and 88 cases of FL were examined.
  
  
  RESULTS
  Interfollicular staining for GC markers was uncommon in MZL but common in FL, including BCL2-positive and BCL2-negative cases. Two atypical patterns of intrafollicular GC staining were identified that were more common in MZL than in FL.
  
  
  CONCLUSIONS
  Staining for LMO2 in addition to CD10 and BCL6 facilitates the detection of a GC phenotype in FL. Lymph nodes involved by MZL frequently show characteristic alterations of GC immunoarchitecture. Recognizing these altered patterns assists in the distinction between MZL and FL.
authors.affiliation: Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Kathryn S
authors.initials: KS
authors.lastname: Dyhdalo
authors.forename: Christopher
authors.initials: C
authors.lastname: Lanigan
authors.forename: Raymond R
authors.initials: RR
authors.lastname: Tubbs
authors.forename: James R
authors.initials: JR
authors.lastname: Cook
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D018858:Germinal Center / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D060588:LIM Domain Proteins / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D015260:Neprilysin / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C411984:BCOR protein, human; D014408:Biomarkers, Tumor; D060588:LIM Domain Proteins; C085117:LMO2 protein, human; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D015260:Neprilysin
keywords: Follicular lymphoma; Germinal center; Immunohistochemistry; LMO2; Lymphoma; Marginal zone lymphoma