title: AIDS alters the commensal plasma virome.
abstract: We compared the plasma viromes of HIV-infected subjects with low versus high CD4(+) T cell counts from the United States and Uganda by using deep sequencing and detected HIV, hepatitis C virus, hepatitis B virus, GB virus C, anellovirus, and human endogenous retrovirus (HERV) reads. An increase in the proportion of reads for anelloviruses, a family of highly prevalent and genetically diverse human viruses, was seen in subjects with AIDS from both countries. The proportion of endogenous human retrovirus reads was increased in AIDS subjects from Uganda but not the United States. Progression to AIDS is therefore associated with changes in the plasma concentration of commensal viruses.
authors.affiliation: Blood Systems Research Institute, San Francisco, California, USA.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.forename: Xutao
authors.initials: X
authors.lastname: Deng
authors.forename: Piyada
authors.initials: P
authors.lastname: Linsuwanon
authors.forename: David
authors.initials: D
authors.lastname: Bangsberg
authors.forename: Mwebesa Bosco
authors.initials: MB
authors.lastname: Bwana
authors.forename: Peter
authors.initials: P
authors.lastname: Hunt
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Martin
authors.forename: Steven G
authors.initials: SG
authors.lastname: Deeks
authors.forename: Eric
authors.initials: E
authors.lastname: Delwart
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000821:virology; D000328:Adult; D049811:Anelloviridae / Q000472:pathogenicity; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000235:genetics; D018450:Disease Progression; D005260:Female; D018178:Flaviviridae Infections / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D029407:GB virus C / Q000378:metabolism / Q000472:pathogenicity; D006678:HIV / Q000378:metabolism / Q000472:pathogenicity*; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D014454:Uganda / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D019562:Viral Load; D014779:Virus Replication; D055815:Young Adult
chemical_list: D004279:DNA, Viral
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