title: A rapid route to aminocyclopropanes via carbamatoorganozinc carbenoids.
abstract: Easy as 1,2,3: Reaction of methyl carbamate, triethyl orthoformate, and readily available alkenes provides a highly practical preparation of protected aminocyclopropanes. The reaction proceeds with preferential cis addition to alkenes, and cleavage of the methyl carbamate gives the free aminocyclopropanes as their HI salts.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon St, London, WC1H 0AJ (UK) http://www.ucl.ac.uk/chemistry; Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, Ube 755-8611 (Japan).
authors.forename: Shingo
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Tom D
authors.initials: TD
authors.lastname: Sheppard
authors.forename: Jarryl M
authors.initials: JM
authors.lastname: D'Oyley
authors.forename: Akio
authors.initials: A
authors.lastname: Kamimura
authors.forename: William B
authors.initials: WB
authors.lastname: Motherwell
mesh_terms: D000475:Alkenes; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D003521:Cyclopropanes; D003300:Copper
keywords: carbenoids; copper; small ring systems; synthetic methods; zinc
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