title: Association between single nucleotide polymorphisms of the estrogen receptor 1 and receptor activator of nuclear factor kappa B ligand genes and bone mineral density in postmenopausal Taiwanese.
abstract: OBJECTIVE
  To investigate the relationship between single nucleotide polymorphisms (SNPs) of the genes encoding the estrogen receptor 1 (ESR1) and the receptor activator of nuclear factor kappa B ligand (RANKL) and bone mineral density (BMD) in postmenopausal Taiwanese.
  
  
  METHODS
  Five ESR1 SNPs and three RANKL SNPs in 467 women were genotyped. Results of genotyping were correlated with BMD that had been adjusted for body mass index (BMI), age, and years after menopause.
  
  
  RESULTS
  Those with the ESR1 Crs1884054 allele were found to have a lower BMD at LS2-4/Lateral view (p = 0.005 and permutated p = 0.046), and those with the ESR1 haplotype Trs2234693-Ars922996 had a higher risk for low BMD also at LS2-4/Lat (OR = 1.8, 95% CI = 1.1-2.9). In addition, women without the RANKL haplotype Grs2148072-Crs2200287-Grs922996 had a higher risk for low BMD at LS1-4/AP (OR = 2.09, 95% CI = 1.21 ∼ 3.64). Stratification analyses revealed that those with ESR1 AArs1884054 and RANKL Ars2148072 (p = 0.032) or RANKL Trs2200287 (p = 0.007) had a lower BMD at LS1-4/AP.
  
  
  CONCLUSIONS
  Genotypes of these SNPs of ESR1 and RANKL may help us predict the osteoporosis risk in menopausal women.
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
authors.forename: Bi-Hua
authors.initials: BH
authors.lastname: Cheng
authors.forename: Tzu-Hao
authors.initials: TH
authors.lastname: Wang
authors.forename: Hong-Yo
authors.initials: HY
authors.lastname: Kang
authors.forename: Ying-Chu
authors.initials: YC
authors.lastname: Lin
authors.forename: Chun-Chen
authors.initials: CC
authors.lastname: Huang
authors.forename: Te-Yao
authors.initials: TY
authors.lastname: Hsu
authors.forename: Fu-Tsai
authors.initials: FT
authors.lastname: Kung
authors.forename: Ko-En
authors.initials: KE
authors.lastname: Huang
mesh_terms: D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D015519:Bone Density / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000208:ethnology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000235:genetics; D053245:RANK Ligand / Q000235:genetics*; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D053245:RANK Ligand; C505688:TNFSF11 protein, human
keywords: ESR1; RANKL; TNFSF11; bone mineral density; single nucleotide polymorphism