title: IDH1 mutation is associated with improved overall survival in patients with glioblastoma: a meta-analysis.
abstract: Previous studies proposed that isocitrate dehydrogenase 1 (IDH1) mutation was associated with improved survival in patients with glioblastoma, but those studies reported varying estimates and yielded inconclusive results. The purpose of the present study was to determine the effect of IDH1 mutation on the prognosis of patients with glioblastoma by performing a meta-analysis. Pubmed and Embase databases were searched for eligible studies. Studies reporting overall survival by IDH1 mutation in patients with glioblastoma were considered potentially eligible for the meta-analysis. For the quantitative aggregation of the survival results, the IDH mutation effect was measured by the pooled hazard ratio (HR) with its 95% confidence interval (95%CI). Nine studies with a total of 1,669 patients with glioblastoma were finally included into this meta-analysis. Overall, the IDH1 mutation was associated with improved survival in patients with glioblastoma (random effects model HR = 0.45, 95%CI 0.29-0.69, P < 0.001). Sensitivity analysis further showed that the pooled estimates were stable in this meta-analysis. Therefore, the findings from this meta-analysis suggest that IDH1 mutation is associated with improved overall survival in patients with glioblastoma.
authors.affiliation: Department of Neurosurgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Cheng
authors.forename: Wu
authors.initials: W
authors.lastname: Yue
authors.forename: Chen
authors.initials: C
authors.lastname: Xie
authors.forename: Ru-You
authors.initials: RY
authors.lastname: Zhang
authors.forename: Shao-Shan
authors.initials: SS
authors.lastname: Hu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D015999:Multivariate Analysis; D009154:Mutation; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human
references.citation: PLoS One. 2012;7(1):e30339
references.pmid: 22291938
references.citation: Ann Neurol. 2011 Jul;70(1):9-21
references.pmid: 21786296
references.citation: Expert Rev Neurother. 2011 Oct;11(10):1399-409
references.pmid: 21955197
references.citation: Neurosurg Clin N Am. 2012 Jul;23(3):471-80
references.pmid: 22748659
references.citation: Cancer Sci. 2012 Mar;103(3):587-92
references.pmid: 22136423
references.citation: Oncol Res. 2000;12(2):107-12
references.pmid: 11132923
references.citation: Cancer. 2013 Feb 15;119(4):806-13
references.pmid: 23184331
references.citation: J Clin Oncol. 2008 Sep 1;26(25):4189-99
references.pmid: 18757334
references.citation: Brain Tumor Pathol. 2012 Jul;29(3):131-9
references.pmid: 22399191
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: J Clin Oncol. 2009 Dec 1;27(34):5743-50
references.pmid: 19805672
references.citation: Acta Neuropathol. 2010 Apr;119(4):487-94
references.pmid: 20127344
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: J Neurooncol. 2011 Nov;105(2):325-35
references.pmid: 21523485
references.citation: J Natl Cancer Inst. 2010 Jul 7;102(13):932-41
references.pmid: 20513808
references.citation: J Neurooncol. 2012 Dec;110(3):325-33
references.pmid: 23015095
references.citation: Lancet Oncol. 2008 Sep;9(9):884-91
references.pmid: 18760244
references.citation: J Clin Pathol. 2011 Oct;64(10):835-44
references.pmid: 21752797
references.citation: Acta Neuropathol. 2010 Dec;120(6):707-18
references.pmid: 21088844
references.citation: Cancer. 2013 Feb 15;119(4):814-24
references.pmid: 22990979
references.citation: Genes Dev. 2012 Apr 15;26(8):756-84
references.pmid: 22508724
references.citation: Br J Neurosurg. 2012 Apr;26(2):189-94
references.pmid: 22176646
references.citation: J Clin Oncol. 2009 Sep 1;27(25):4150-4
references.pmid: 19636000
references.citation: Hematol Oncol Clin North Am. 2012 Aug;26(4):825-53
references.pmid: 22794286
references.citation: Oncogene. 2010 Dec 9;29(49):6409-17
references.pmid: 20972461