title: Incidence trends in pathogen-specific central line-associated bloodstream infections in US intensive care units, 1990-2010.
abstract: OBJECTIVE
  To quantify historical trends in rates of central line-associated bloodstream infections (CLABSIs) in US intensive care units (ICUs) caused by major pathogen groups, including Candida spp., Enterococcus spp., specified gram-negative rods, and Staphylococcus aureus.
  
  
  METHODS
  Active surveillance in a cohort of participating ICUs through the Centers for Disease Control and Prevention, the National Nosocomial Infections Surveillance system during 1990-2004, and the National Healthcare Safety Network during 2006-2010. Setting. ICUs. Participants. Patients who were admitted to participating ICUs.
  
  
  RESULTS
  The CLABSI incidence density rate for S. aureus decreased annually starting in 2002 and remained lower than for other pathogen groups. Since 2006, the annual decrease for S. aureus CLABSIs in nonpediatric ICU types was -18.3% (95% confidence interval [CI], -20.8% to -15.8%), whereas the incidence density rate for S. aureus among pediatric ICUs did not change. The annual decrease for all ICUs combined since 2006 was -17.8% (95% CI, -19.4% to -16.1%) for Enterococcus spp., -16.4% (95% CI, -18.2% to -14.7%) for gram-negative rods, and -13.5% (95% CI, -15.4% to -11.5%) for Candida spp.
  
  
  CONCLUSIONS
  Patterns of ICU CLABSI incidence density rates among major pathogen groups have changed considerably during recent decades. CLABSI incidence declined steeply since 2006, except for CLABSI due to S. aureus in pediatric ICUs. There is a need to better understand CLABSIs that still do occur, on the basis of microbiological and patient characteristics. New prevention approaches may be needed in addition to central line insertion and maintenance practices.
authors.affiliation: National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA. fev3@cdc.gov
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Fagan
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Edwards
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Park
authors.forename: Scott K
authors.initials: SK
authors.lastname: Fridkin
authors.forename: Shelley S
authors.initials: SS
authors.lastname: Magill
mesh_terms: D002177:Candidiasis / Q000453:epidemiology / Q000209:etiology; D055499:Catheter-Related Infections / Q000453:epidemiology* / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000209:etiology; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000209:etiology; D014481:United States / Q000453:epidemiology
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