title: Ability of lactic acid bacteria isolated from mink to remove cholesterol: in vitro and in vivo studies.
abstract: This study evaluated the cholesterol-lowering property of lactic acid bacteria (LAB) isolated from mink. Two strains, Enterococcus faecium MDF1104 and Lactobacillus plantarum MDL1118, were shown to remove cholesterol from broths of natural hen egg yolk and skimmed milk. The cholesterol in hen egg yolk was reduced by 58.15% and 38% by L. plantarum and E. faecium, respectively. When the bacteria were used in combination, 48.95% (p < 0.01) of cholesterol was removed from skimmed milk. Experimental mice remained healthy when fed different doses of the LAB, and the total serum cholesterol concentration was the lowest (0.90 mmol/L) (p < 0.01) when a combination of L. plantarum and E. faecium was used. Based on our results, we suggest that L. plantarum MDL1118, E. faecium MDF1104, or a combination of the 2 strains could be considered as promising cholesterol-lowering probiotics.
authors.affiliation: Institute of Special Animal and Plant Science, Chinese Academy of Agricultural Sciences, Jilin 130122, People's Republic of China.
authors.forename: Hanlu
authors.initials: H
authors.lastname: Liu
authors.forename: Chenjie
authors.initials: C
authors.lastname: Yang
authors.forename: Yi
authors.initials: Y
authors.lastname: Jing
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhong
authors.forename: Guangyu
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D004530:Egg Yolk / Q000737:chemistry; D016984:Enterococcus faecium / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D005516:Food Microbiology; D048191:Lactiplantibacillus plantarum / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008892:Milk / Q000737:chemistry / Q000382:microbiology; D008907:Mink / Q000382:microbiology*; D019936:Probiotics; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol