title: Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis.
abstract: OBJECTIVE
  To analyze the prevalence of myositis-specific and myositis-associated autoantibodies and their clinical correlations in a large series of patients with dermatomyositis/polymyositis.
  
  
  METHODS
  This cross-sectional study enrolled 127 dermatomyositis cases and 95 polymyositis cases. The disease-related autoantibody profiles were determined using a commercially available blood testing kit.
  
  
  RESULTS
  The prevalence of myositis-specific autoantibodies in all 222 patients was 34.4%, whereas myositis-associated autoantibodies were found in 41.4% of the patients. The most frequently found autoantibody was anti-Ro-52 (36.9%), followed by anti-Jo-1 (18.9%), anti-Mi-2 (8.1%), anti-Ku (4.1%), anti-SRP (3.2%), anti-PL-7 (3.2%), anti-PL-12 (2.7%), anti-PM/Scl75 (2.7%), and anti-PM/Scl100 (2.7%). The distributions of these autoantibodies were comparable between polymyositis and dermatomyositis, except for a higher prevalence of anti-Jo-1 in polymyositis. Anti-Mi-2 was more prevalent in dermatomyositis. Notably, in the multivariate analysis, anti-Mi-2 and anti-Ro-52 were associated with photosensitivity and pulmonary disorders, respectively, in dermatomyositis. Anti-Jo-1 was significantly correlated with pulmonary disorders in polymyositis. Moreover, anti-Ro-52 was associated with anti-Jo-1 in both diseases. No significant correlation was observed between the remaining autoantibodies and the clinical and/or laboratory findings.
  
  
  CONCLUSIONS
  Our data are consistent with those from other published studies involving other populations, although certain findings warrant consideration. Anti-Ro-52 and anti-Jo-1 were strongly associated with one another. Anti-Ro-52 was correlated with pulmonary disorders in dermatomyositis, whereas anti-Jo-1 was correlated with pulmonary alterations in polymyositis.
authors.affiliation: Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Marcela Gran Pina
authors.initials: MG
authors.lastname: Cruellas
authors.forename: Vilma dos Santos Trindade
authors.initials: Vdos S
authors.lastname: Viana
authors.forename: Maurício
authors.initials: M
authors.lastname: Levy-Neto
authors.forename: Fernando Henrique Carlos de
authors.initials: FH
authors.lastname: Souza
authors.forename: Samuel Katsuyuki
authors.initials: SK
authors.lastname: Shinjo
mesh_terms: D000328:Adult; D017668:Age of Onset; D001323:Autoantibodies / Q000097:blood*; D003430:Cross-Sectional Studies; D003882:Dermatomyositis / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008171:Lung Diseases / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D009220:Myositis / Q000097:blood / Q000276:immunology*; D012261:Ribonucleoproteins / Q000097:blood; D018709:Statistics, Nonparametric; D013997:Time Factors; D000099207:SS-A Antigen
chemical_list: D001323:Autoantibodies; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C045760:Mi-2 antibodies
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