title: Evoked potentials in the Atlantic cod following putatively innocuous and putatively noxious electrical stimulation: a minimally invasive approach.
abstract: Aspects of peripheral and central nociception have previously been studied through recording of somatosensory evoked potentials (SEPs) to putative noxious stimuli in specific brain regions in a few freshwater fish species. In the present study, we describe a novel, minimally invasive method for recording SEPs from the central nervous system of the Atlantic cod (Gadus morhua). Cutaneous electric stimulation of the tail in 15 fish elicited SEPs at all stimulus intensities (2, 5, 10 and 20 mA) with quantitative properties corresponding to stimulus intensity. In contrast to previous fish studies, the methodological approach used in Atlantic cod in the current study uncovered a number of additional responses that could originate from multiple brain regions. Several of these responses were specific to stimulation at the highest stimulus intensities, possibly representing qualitative differences in central processing between somatosensory and nociceptive stimuli.
authors.affiliation: Department of Arctic and Marine Biology, Faculty of Biosciences, Fisheries and Economics, University of Tromsø, 9037, Tromsö, Norway, stian.ludvigsen@uit.no.
authors.forename: Stian
authors.initials: S
authors.lastname: Ludvigsen
authors.forename: Niels C
authors.initials: NC
authors.lastname: Stenklev
authors.forename: Helge K
authors.initials: HK
authors.lastname: Johnsen
authors.forename: Einar
authors.initials: E
authors.lastname: Laukli
authors.forename: Dagfinn
authors.initials: D
authors.lastname: Matre
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Aas-Hansen
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials; D048389:Gadus morhua / Q000502:physiology*; D059225:Nociception
references.citation: J Clin Neurophysiol. 2000 May;17(3):295-308
references.pmid: 10928641
references.citation: J Pain. 2005 Sep;6(9):561-8
references.pmid: 16139775
references.citation: Neurosci Lett. 2001 Jan 19;297(3):183-6
references.pmid: 11137758
references.citation: Brain Res. 2007 Aug 29;1166:47-54
references.pmid: 17673186
references.citation: Pharmacol Biochem Behav. 1982 Oct;17(4):757-61
references.pmid: 6129644
references.citation: Pain. 1979 Jun;6(3):249
references.pmid: 460932
references.citation: Neuroscience. 2003;120(1):235-48
references.pmid: 12849756
references.citation: J Neurosci Methods. 2003 Jun 15;126(1):79-90
references.pmid: 12788504
references.citation: Pain. 2008 Jul 31;137(3):473-477
references.pmid: 18583048
references.citation: J Neural Transm (Vienna). 2009 Oct;116(10):1237-42
references.pmid: 19728032
references.citation: Eur J Pain. 2010 Mar;14(3):321-6
references.pmid: 19481484
references.citation: J Pain Symptom Manage. 2003 Jan;25(1):64-73
references.pmid: 12565190
references.citation: J Anat. 2005 Jul;207(1):19-33
references.pmid: 16011543
references.citation: Neurosci Lett. 2002 Feb 22;319(3):167-71
references.pmid: 11834319
references.citation: Proc Biol Sci. 2003 Jun 7;270(1520):1115-21
references.pmid: 12816648
references.citation: J Comp Physiol A. 1998 Mar;182(3):307-18
references.pmid: 9528109
references.citation: Lancet. 2010 Oct 9;376(9748):1225-32
references.pmid: 20817247
references.citation: Pain. 1999 Feb;79(2-3):105-11
references.pmid: 10068155
references.citation: Int J Audiol. 2009;48(7):456-64
references.pmid: 19925332
references.citation: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2007 Dec;193(12):1235-42
references.pmid: 17987296
references.citation: Dis Aquat Organ. 2007 May 4;75(2):139-54
references.pmid: 17578253
references.citation: Brain Res. 2003 May 16;972(1-2):44-52
references.pmid: 12711077
references.citation: Clin Neurophysiol. 2005 Apr;116(4):743-63
references.pmid: 15792883
references.citation: Physiol Behav. 2010 Nov 2;101(4):533-40
references.pmid: 20705079
references.citation: Neuroimage. 2010 Aug 15;52(2):583-9
references.pmid: 20438855
references.citation: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 Dec;195(12):1089-106
references.pmid: 19830434
references.citation: Electromyogr Clin Neurophysiol. 1994 Jan-Feb;34(1):49-51
references.pmid: 8168457
references.citation: New Sci. 1992 Apr 25;134(1818):30-3
references.pmid: 11656113
references.citation: Brain Res Bull. 1988 Dec;21(6):923-31
references.pmid: 2906273
references.citation: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2002 Aug;188(7):561-76
references.pmid: 12209344