title: Diabetic ketoacidosis secondary to L-asparaginase in acute lymphoblastic leukaemia.
abstract: We describe a case of severe hyperglycaemia resulting in diabetic ketoacidosis secondary to L-asparaginase. There are few reports of this potentially life-threatening complication, particularly in the English literature. Awareness and recognition of this preventable and manageable problem will improve safe delivery of this anti-leukaemic drug.
authors.affiliation: Department of Haematology, St Vincent's Public Hospital, Sydney, New South Wales, Australia. grace.cheung@unswalumni.com
authors.forename: G
authors.initials: G
authors.lastname: Gifford
authors.forename: S
authors.initials: S
authors.lastname: Milliken
authors.forename: J
authors.initials: J
authors.lastname: Greenfield
mesh_terms: D000293:Adolescent; D001215:Asparaginase / Q000009:adverse effects*; D016883:Diabetic Ketoacidosis / Q000139:chemically induced* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D001215:Asparaginase
keywords: L-asparaginase; diabetes; diabetic ketoacidosis; hyperglycaemia; insulin; leukaemia