title: Rs12218 In SAA1 gene was associated with serum lipid levels.
abstract: BACKGROUND
  Serum amyloid A (SAA) is a kind of apolipoprotein. Several studies indicated that SAA genetic polymorphism rs12218 was associated with carotid atherosclerosis, peripheral arterial disease, and serum uric acid levels. However, the relation between rs12218 and lipid levels remains unclear. This study assessed the correlation between SAA1 gene rs12218 polymorphism and lipid levels in a Chinese population.
  
  
  METHODS
  A total of 823 participants were selected from the subjects for health check in Shanghai Huashan hospital from Jan. 2013 to Mach. 2013. Correlations between rs12218 polymorphism and lipid levels were investigated through the identification of rs12218 genotypes using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  We found that the SNP rs12218 was associated with triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL-C) levels by analyses of a dominant model (P<0.001, P=0.002, P=0.003, respectively), a recessive model (P<0.001, P=0.001, P=0.005, respectively) and an additive model (P<0.001, P=0.001, P=0.002, respectively), and the difference remained significant after the adjustment of sex, age, alcohol intake, and smoking (All P<0.01).
  
  
  CONCLUSIONS
  Our results indicated that the rs12218 in the SAA1gene was associated with lipid levels in a Chinese population.
authors.affiliation: Department of Cardiothoracic Surgery, Huashan Hospital, Fudan University, Shanghai 200032, PR China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Xu
authors.forename: Xiao-Tian
authors.initials: XT
authors.lastname: Sun
authors.forename: Liewen
authors.initials: L
authors.lastname: Pang
authors.forename: Guoqian
authors.initials: G
authors.lastname: Huang
authors.forename: Jiechun
authors.initials: J
authors.lastname: Huang
authors.forename: Meng
authors.initials: M
authors.lastname: Shi
authors.forename: Yi-Qing
authors.initials: YQ
authors.lastname: Wang
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000685:Serum Amyloid A Protein / Q000235:genetics*; D014280:Triglycerides / Q000097:blood / Q000235:genetics
chemical_list: D008055:Lipids; C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein; D014280:Triglycerides
references.citation: PLoS One. 2013 Jun 04;8(6):e64974
references.pmid: 23750222
references.citation: Rev Iberoam Micol. 2015 Jan-Mar;32(1):25-9
references.pmid: 23603100
references.citation: PLoS One. 2010 Dec 02;5(12):e15181
references.pmid: 21152041
references.citation: Eur J Prev Cardiol. 2012 Jun;19(3):314-21
references.pmid: 21450566
references.citation: Scand J Immunol. 1999 Aug;50(2):183-7
references.pmid: 10447923
references.citation: Clin Biochem. 1993 Dec;26(6):505-11
references.pmid: 8124866
references.citation: Blood Press. 2011 Aug;20(4):232-8
references.pmid: 21449704
references.citation: J Lipid Res. 2011 Dec;52(12):2255-2261
references.pmid: 21957202
references.citation: Lipids Health Dis. 2013 Mar 22;12:39
references.pmid: 23522429
references.citation: Arthritis Rheum. 2001 Jun;44(6):1266-72
references.pmid: 11407685
references.citation: Am J Respir Crit Care Med. 2013 Jul 15;188(2):179-86
references.pmid: 23627303
references.citation: Atherosclerosis. 2013 Jun;228(2):370-9
references.pmid: 23623642
references.citation: PLoS One. 2010 Nov 16;5(11):e13997
references.pmid: 21103356
references.citation: Hepatol Res. 2014 May;44(5):584-90
references.pmid: 23607539
references.citation: J Atheroscler Thromb. 2009 Aug;16(4):419-30
references.pmid: 19729864
references.citation: Amyloid. 1999 Mar;6(1):37-47
references.pmid: 10211410
references.citation: PLoS One. 2012;7(6):e40263
references.pmid: 22768267