title: Characterizations and functions of regulator of G protein signaling (RGS) in fungi.
abstract: Proteins that serve as regulator of G protein signaling (RGS) primarily function as GTPase accelerators that promote GTP hydrolysis by the Gα subunits, thereby inactivating the G protein and rapidly switching off G protein-coupled signaling pathways. Since the first RGS protein was identified from the budding yeast Saccharomyces cerevisiae, more than 30 RGS and RGS-like proteins have been characterized from several model fungi, such as Aspergillus nidulans, Beauveria bassiana, Candida albicans, Fusarium verticillioides, Magnaporthe oryzae, and Metarhizium anisopliae. In this review, the partial biochemical properties and functional domains of RGS and RGS-like proteins were predicted and compared, and the roles of RGS and RGS-like proteins in different fungi were summarized. Moreover, the phylogenetic relationship among RGS and RGS-like proteins from various fungi was analyzed and discussed.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: Yunchuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Zongyi
authors.initials: Z
authors.lastname: Geng
authors.forename: Dewei
authors.initials: D
authors.lastname: Jiang
authors.forename: Fangfang
authors.initials: F
authors.lastname: Long
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hao
authors.initials: H
authors.lastname: Su
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
authors.forename: Jinkui
authors.initials: J
authors.lastname: Yang
mesh_terms: D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005658:Fungi / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D020710:RGS Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D020710:RGS Proteins