title: Synthesis and SAR studies of praziquantel derivatives with activity against Schistosoma japonicum.
abstract: The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.
authors.affiliation: School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China.
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Wang
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Song
authors.forename: Xia
authors.initials: X
authors.lastname: Chen
authors.forename: Xu-Ren
authors.initials: XR
authors.lastname: Yin
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Fan
authors.forename: Gu-Ping
authors.initials: GP
authors.lastname: Wang
authors.forename: Chuan-Xin
authors.initials: CX
authors.lastname: Yu
authors.forename: Bainian
authors.initials: B
authors.lastname: Feng
mesh_terms: D000818:Animals; D015394:Molecular Structure; D011223:Praziquantel / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D012549:Schistosoma japonicum / Q000187:drug effects* / Q000472:pathogenicity; D012552:Schistosomiasis / Q000188:drug therapy* / Q000469:parasitology; D012556:Schistosomicides / Q000008:administration & dosage; D013329:Structure-Activity Relationship
chemical_list: D012556:Schistosomicides; D011223:Praziquantel
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