title: Influence of obstructive sleep apnea on serum butyrylcholinesterase activity and ischemia-modified albumin levels.
abstract: OBJECTIVE
  To investigate the effect of obstructive sleep apnea and continuous positive airway pressure treatment on serum butyrylcholinesterase activity and ischemia-modified albumin levels.
  
  
  METHODS
  Thirty-two patients with obstructive sleep apnea and 30 age- and sex-matched controls were enrolled and underwent a diagnostic polysomnogram. The serum butyrylcholinesterase activity, ischemia-modified albumin levels, metabolic parameters, and polysomnography scores were detected and evaluated. Nine patients were studied before and after treatment with continuous positive airway pressure.
  
  
  RESULTS
  The serum ischemia-modified albumin levels were significantly higher and the butyrylcholinesterase activity was significantly lower in patients with obstructive sleep apnea than in the controls (p<0.001). The continuous positive airway pressure treatment decreased the modified albumin levels and elevated the buthrylcholinesterase activity (p=0.019 and p=0.023, respectively). The modified albumin levels were positively correlated with the apnea-hypopnea index (r=0.462, p=0.008) at baseline. Elevated ischemia-modified albumin levels can be more accurate than butyrylcholinesterase activity at reflecting the presence of obstructive sleep apnea. Receiver operating characteristic curves revealed a significant difference between the areas under the curve 0.916 for ischemia-modified albumin and 0.777 for butyrylcholinesterase (z=2.154, p=0.031).
  
  
  CONCLUSIONS
  The elevated ischemia-modified albumin level was significantly associated with obstructive sleep apnea and was more sensitive than butyrylcholinesterase activity in reflecting obstructive sleep apnea. The continuous positive airway pressure treatment helped to ameliorate the imbalance.
authors.affiliation: Guangxi Medical University Graduate School, Guangxi, China.
authors.forename: Liu-Xue
authors.initials: LX
authors.lastname: Yang
authors.forename: Shao-Gang
authors.initials: SG
authors.lastname: Ma
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002091:Butyrylcholinesterase / Q000097:blood*; D016022:Case-Control Studies; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012016:Reference Values; D012044:Regression Analysis; D012307:Risk Factors; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D002091:Butyrylcholinesterase; D000075462:Serum Albumin, Human
references.citation: Prog Neurobiol. 1993 Jul;41(1):31-91
references.pmid: 8321908
references.citation: Sleep Med Rev. 2003 Feb;7(1):35-51
references.pmid: 12586529
references.citation: Clinics (Sao Paulo). 2012;67(6):565-72
references.pmid: 22760893
references.citation: Med Sci Monit. 2007 Dec;13(12):RA214-21
references.pmid: 18049445
references.citation: Thorax. 2009 Jul;64(7):581-6
references.pmid: 19074930
references.citation: Clin Chem Lab Med. 2011 Nov;49(11):1817-21
references.pmid: 21851314
references.citation: Sleep Breath. 2012 Jun;16(2):499-504
references.pmid: 21567336
references.citation: Respir Med. 2007 Jun;101(6):1283-90
references.pmid: 17127049
references.citation: Sleep Breath. 2012 Jun;16(2):511-7
references.pmid: 21614576
references.citation: Chin Med J (Engl). 2011 Dec;124(24):4127-31
references.pmid: 22340373
references.citation: Clin Biochem. 2011 Jun;44(8-9):623-6
references.pmid: 21402063
references.citation: J Nephrol. 2010 May-Jun;23(3):335-40
references.pmid: 20349416
references.citation: Eur Respir J. 2009 Jun;33(6):1467-84
references.pmid: 19483049
references.citation: Clin Biochem. 2005 Sep;38(9):799-805
references.pmid: 15907830
references.citation: Intern Med. 2012;51(4):363-8
references.pmid: 22333370
references.citation: Clinics (Sao Paulo). 2006 Jun;61(3):253-66
references.pmid: 16832559
references.citation: Intern Med. 2009;48(15):1255-62
references.pmid: 19652426
references.citation: Med Sci Monit. 2011 Sep;17(9):CR491-7
references.pmid: 21873945
references.citation: PLoS One. 2010 Aug 11;5(8):e12065
references.pmid: 20711453
references.citation: Semin Thromb Hemost. 2011 Apr;37(3):280-97
references.pmid: 21455862
references.citation: Clin Biochem. 2011 Nov;44(16):1299-303
references.pmid: 21906585
references.citation: J Obstet Gynaecol. 2010 Feb;30(2):122-6
references.pmid: 20143968
references.citation: Clinics (Sao Paulo). 2011;66(10):1677-80
references.pmid: 22012037