title: Deep brain stimulation of the globus pallidus suppresses post-traumatic dystonic tremor.
abstract: Dystonic tremor is an unusual movement disorder that is highly disabling and difficult to treat medically. We describe an 18-year-old patient with dystonic tremor whose medical treatment failed, and was considered for surgery. The patient had a long-standing dystonic tremor and was recommended for globus pallidus (GP) deep brain stimulation. At 2 year follow-up, we observed substantial tremor suppression and best clinical effect with contact three, which, radiographically, is located in the internal globus pallidus/external globus pallidus transition area. The stimulation was more rostral than expected. We conclude that the GP is a potentially useful therapeutic target for dystonic tremor.
authors.affiliation: St Christopher's Hospital For Children, Department of Neurology, Philadelphia, PA, USA.
authors.forename: Karen S
authors.initials: KS
authors.lastname: Carvalho
authors.affiliation: Temple University, Department of Neurosurgery, 3401 N. Broad Street, Suite C540, Philadelphia, PA 19140, USA.
authors.forename: Vishad V
authors.initials: VV
authors.lastname: Sukul
authors.affiliation: Temple University, Department of Neurosurgery, 3401 N. Broad Street, Suite C540, Philadelphia, PA 19140, USA.
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Bookland
authors.affiliation: Bromedicon, Inc., Yardley, PA, USA.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Koch
authors.affiliation: Temple University, Department of Neurosurgery, 3401 N. Broad Street, Suite C540, Philadelphia, PA 19140, USA. Electronic address: patrconn@temple.edu.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Connolly
mesh_terms: D000293:Adolescent; D001930:Brain Injuries / Q000150:complications; D046690:Deep Brain Stimulation / Q000379:methods*; D020821:Dystonic Disorders / Q000209:etiology / Q000628:therapy*; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D014202:Tremor / Q000209:etiology / Q000628:therapy*
keywords: Brain trauma; Dystonia; Dystonic tremor; Stimulation; Surgery