title: A trial of intraoperative low-tidal-volume ventilation in abdominal surgery.
abstract: BACKGROUND
  Lung-protective ventilation with the use of low tidal volumes and positive end-expiratory pressure is considered best practice in the care of many critically ill patients. However, its role in anesthetized patients undergoing major surgery is not known.
  
  
  METHODS
  In this multicenter, double-blind, parallel-group trial, we randomly assigned 400 adults at intermediate to high risk of pulmonary complications after major abdominal surgery to either nonprotective mechanical ventilation or a strategy of lung-protective ventilation. The primary outcome was a composite of major pulmonary and extrapulmonary complications occurring within the first 7 days after surgery.
  
  
  RESULTS
  The two intervention groups had similar characteristics at baseline. In the intention-to-treat analysis, the primary outcome occurred in 21 of 200 patients (10.5%) assigned to lung-protective ventilation, as compared with 55 of 200 (27.5%) assigned to nonprotective ventilation (relative risk, 0.40; 95% confidence interval [CI], 0.24 to 0.68; P=0.001). Over the 7-day postoperative period, 10 patients (5.0%) assigned to lung-protective ventilation required noninvasive ventilation or intubation for acute respiratory failure, as compared with 34 (17.0%) assigned to nonprotective ventilation (relative risk, 0.29; 95% CI, 0.14 to 0.61; P=0.001). The length of the hospital stay was shorter among patients receiving lung-protective ventilation than among those receiving nonprotective ventilation (mean difference, -2.45 days; 95% CI, -4.17 to -0.72; P=0.006).
  
  
  CONCLUSIONS
  As compared with a practice of nonprotective mechanical ventilation, the use of a lung-protective ventilation strategy in intermediate-risk and high-risk patients undergoing major abdominal surgery was associated with improved clinical outcomes and reduced health care utilization. (IMPROVE ClinicalTrials.gov number, NCT01282996.).
authors.affiliation: Département d'Anesthésie et Réanimation, Hôpital Estaing, Clermont-Ferrand, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Futier
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Constantin
authors.forename: Catherine
authors.initials: C
authors.lastname: Paugam-Burtz
authors.forename: Julien
authors.initials: J
authors.lastname: Pascal
authors.forename: Mathilde
authors.initials: M
authors.lastname: Eurin
authors.forename: Arthur
authors.initials: A
authors.lastname: Neuschwander
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Marret
authors.forename: Marc
authors.initials: M
authors.lastname: Beaussier
authors.forename: Christophe
authors.initials: C
authors.lastname: Gutton
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Lefrant
authors.forename: Bernard
authors.initials: B
authors.lastname: Allaouchiche
authors.forename: Daniel
authors.initials: D
authors.lastname: Verzilli
authors.forename: Marc
authors.initials: M
authors.lastname: Leone
authors.forename: Audrey
authors.initials: A
authors.lastname: De Jong
authors.forename: Jean-Etienne
authors.initials: JE
authors.lastname: Bazin
authors.forename: Bruno
authors.initials: B
authors.lastname: Pereira
authors.forename: Samir
authors.initials: S
authors.lastname: Jaber
mesh_terms: D000005:Abdomen / Q000601:surgery*; D013505:Digestive System Surgical Procedures; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D057194:Intention to Treat Analysis; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D011175:Positive-Pressure Respiration / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control* / Q000628:therapy; D012131:Respiratory Insufficiency / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D013990:Tidal Volume