title: Heart transplantation in a patient with heteroresistant vancomycin-intermediate Staphylococcus aureus ventricular assist device mediastinitis and bacteremia.
abstract: Vancomycin-intermediate Staphylococcus aureus (VISA) infections are an emerging problem and antibiotic options are limited. We report the first case, to our knowledge, of heteroresistant VISA mediastinitis and bacteremia in a patient with a ventricular assist device who underwent orthotopic heart transplantation with clinical cure.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: T H
authors.initials: TH
authors.lastname: Swartz
authors.forename: S
authors.initials: S
authors.lastname: Huprikar
authors.forename: V
authors.initials: V
authors.lastname: Labombardi
authors.forename: S
authors.initials: S
authors.lastname: Pinney
authors.forename: A
authors.initials: A
authors.lastname: Anyanwu
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: G
authors.initials: G
authors.lastname: Patel
mesh_terms: D000328:Adult; D000617:Aminoglycosides / Q000494:pharmacology / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D003646:Debridement; D017147:Defibrillators, Implantable; D005260:Female; D016027:Heart Transplantation; D006353:Heart-Assist Devices / Q000009:adverse effects / Q000382:microbiology; D006801:Humans; D000077427:Lipoglycopeptides; D008480:Mediastinitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D016896:Treatment Outcome; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use; D020713:Vancomycin Resistance
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077427:Lipoglycopeptides; D014640:Vancomycin; C487637:telavancin
keywords: MRSA; Staphylococcus aureus; hVISA/VISA; orthotopic heart transplantation; telavancin resistance