title: Autism spectrum disorders in babies born to mothers with antiphospholipid syndrome.
abstract: OBJECTIVE
  To evaluate the outcomes of babies born to mothers with primary antiphospholipid syndrome and to compare to the outcomes of babies of mothers with systemic lupus erythematosus.
  
  
  METHODS
  A retrospective study from 2003 to 2010 assessing the clinical characteristics and psychomotor development, as well as the immunological data, of children born to mothers with antiphospholipid syndrome (APS) (group 1) and systemic lupus erythematosus (group 2).
  
  
  RESULTS
  Group 1 consisted of 36 children born to mothers (n = 26) with a primary APS. Autism spectrum disorders occurred in 3 children from group 1 and all of them had persistent anti-β2GP1 IgG antibodies. Group 2 consisted of 12 children born to mothers (n = 9) with lupus erythematosus. Three children experienced cutaneous neonatal lupus, but there were no neurodevelopmental disorders. Comparing children of groups 1 and 2, no significant difference was found with regard to the parameters at birth or during follow-up. The children in group 2 had antinuclear antibodies more frequently (p < 0.05).
  
  
  CONCLUSIONS
  Autism spectrum disorders could be observed in babies born to mothers with antiphospholipid syndrome, but there is no risk of thrombosis.
  
  
  CONCLUSIONS
  Neonatal lupus is well-known complication in children born to mothers with systemic lupus erythematosus, but there is no risk of thrombosis in APS-exposed children. In children of APS mothers the rate of prematurity and small-for-gestational age weight remain high even in treated pregnancy. The presence of several cases of autism spectrum disorders in APS-exposed children could be related to mother's antibodies exposition, but need to be confirmed.
authors.affiliation: Service de médecine interne, Université Paris 13, AP-HP, Hôpital Jean Verdier Bondy, France.
authors.forename: Noémie
authors.initials: N
authors.lastname: Abisror
authors.forename: Arsène
authors.initials: A
authors.lastname: Mekinian
authors.forename: Eric
authors.initials: E
authors.lastname: Lachassinne
authors.forename: Pascale
authors.initials: P
authors.lastname: Nicaise-Roland
authors.forename: Loic
authors.initials: L
authors.lastname: De Pontual
authors.forename: Sylvie
authors.initials: S
authors.lastname: Chollet-Martin
authors.forename: Nathalie
authors.initials: N
authors.lastname: Boddaert
authors.forename: Lionel
authors.initials: L
authors.lastname: Carbillon
authors.forename: Olivier
authors.initials: O
authors.lastname: Fain
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis*; D016241:Child of Impaired Parents; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies
keywords: Antiphospholipid syndrome; Autism; Lupus; Offspring; Outcome