title: Migratory conventional dendritic cells in the induction of peripheral T cell tolerance.
abstract: Conventional DCs are an extremely heterogeneous cell population that comprises several different subsets. A major distinction can be made between lymphoid-resident DCs that are present in the lymphoid tissues and the blood and migratory DCs that reside in the nonlymphoid tissues and migrate to the lymph nodes, both in homeostatic conditions and during the course of an infection. Migratory DCs differ from tissue to tissue but share the unique ability to transport antigens to the draining lymph nodes-in particular, tissue-restricted antigens in homeostatic conditions and microbial antigens after an infection. Recently, steady-state migratory DCs have gained much attention after the discovery of their high tolerogenic potential. The purpose of this review is to give a picture of the recent finding regarding steady-state migratory DCs with particular interest in their role in inducing T cell tolerance.
authors.affiliation: 1.University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. francesca.granucci@unimib.it or ivan.zanoni@unimib.it.
authors.forename: Achille
authors.initials: A
authors.lastname: Broggi
authors.forename: Ivan
authors.initials: I
authors.lastname: Zanoni
authors.forename: Francesca
authors.initials: F
authors.lastname: Granucci
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D002465:Cell Movement; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D039001:Integrin alpha Chains / Q000032:analysis; D008168:Lung / Q000276:immunology; D012867:Skin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D039001:Integrin alpha Chains; C091367:alpha E integrins
keywords: lamina propria; mesenteric lymph nodes; retinoic acid; skin-draining lymph nodes