title: Matrix metalloproteinase7 -181A/G polymorphism is associated with increased cancer risk among high-quality studies: Evidence from a meta-analysis.
abstract: OBJECTIVE
  To evaluate the effect of Matrix metalloproteinase 7 -181A/G polymorphism (rs11568818) on the risk of cancer, we performed a meta-analysis.
  
  
  METHODS
  24 case-control studies were identified by searching Pubmed, Embase, ISI, OVID MEDLINE and EBSCO databases. Odd ratios and corresponding 95% confidence intervals were applied to assess the strength of association between MMP7 -181A/G polymorphism and cancer risk.
  
  
  RESULTS
  Between MMP7 -181GG genotype and cancer risk, statistically significant association could be observed from overall cancer risk, evidently noted in Asians, observed in high-quality subgroup, and apparently witnessed in PCR-RFLP genotyping subgroup.
  
  
  CONCLUSIONS
  Our meta-analysis indicates that MMP7 -181GG genotype is associated with overall cancer risk in Asian populations (especially China and India) among high-quality studies.
authors.affiliation: Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Xuan
authors.initials: X
authors.lastname: Guan
authors.forename: Ya-Ting
authors.initials: YT
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Bai
authors.forename: Jin
authors.initials: J
authors.lastname: Wu
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D020783:Matrix Metalloproteinase 7 / Q000235:genetics*; D008957:Models, Genetic; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7
keywords: Cancer risk; Matrix metalloproteinase; Meta-analysis; Polymorphism