title: Ultrasound assisted particle and cell manipulation on-chip.
abstract: Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.
authors.affiliation: School of Engineering, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
authors.forename: Helen
authors.initials: H
authors.lastname: Mulvana
authors.forename: Sandy
authors.initials: S
authors.lastname: Cochran
authors.forename: Martyn
authors.initials: M
authors.lastname: Hill
mesh_terms: D000162:Acoustics; D000818:Animals; D002470:Cell Survival; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D056656:Lab-On-A-Chip Devices; D045423:Microbubbles; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics; D010316:Particle Size; D014465:Ultrasonics
keywords: Acoustic streaming; Acoustofluidics; Lab-on-chip; Microfluidics; Ultrasonic radiation forces