title: Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles.
abstract: RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.
authors.affiliation: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. zhang@ucsd.edu.
authors.forename: Ronnie H
authors.initials: RH
authors.lastname: Fang
authors.forename: Che-Ming J
authors.initials: CM
authors.lastname: Hu
authors.forename: Kevin N H
authors.initials: KN
authors.lastname: Chen
authors.forename: Brian T
authors.initials: BT
authors.lastname: Luk
authors.forename: Cody W
authors.initials: CW
authors.lastname: Carpenter
authors.forename: Weiwei
authors.initials: W
authors.lastname: Gao
authors.forename: Shulin
authors.initials: S
authors.lastname: Li
authors.forename: Dong-Er
authors.initials: DE
authors.lastname: Zhang
authors.forename: Weiyue
authors.initials: W
authors.lastname: Lu
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry; D001483:Base Sequence; D045744:Cell Line, Tumor; D004910:Erythrocyte Membrane / Q000737:chemistry* / Q000378:metabolism; D005434:Flow Cytometry; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D000097796:Nucleolin
chemical_list: D052157:Aptamers, Nucleotide; D016650:Fluorescein-5-isothiocyanate; D005492:Folic Acid; D008055:Lipids; D010750:Phosphoproteins; D011092:Polyethylene Glycols; D016601:RNA-Binding Proteins; D000097796:Nucleolin
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