title: The interaction between human enteroviruses and type I IFN signaling pathway.
abstract: Human enteroviruses (HEV), very common and important human pathogens, cause infections in diverse ways. Recently, the large epidemic of HFMD caused by HEV infection became a growing threat to public health in China. As the first line of immune response, the type I interferon (IFN-α/β) pathway plays an essential role in antiviral infection, particularly in limiting both the early and late stages of infection. Because of co-evolution with the host, the viruses have evolved multiple strategies to evade or subvert the host immunity to ensure their survival. In this paper, we systematically reviewed and summarized the interaction between HEV infections and host type I IFN responses. We firstly described the recent findings of HEV recognition and IFN induction, specifically on host pattern-recognition receptors (PRRs) in HEV infection. Then we discussed the antiviral effect of IFN in HEV infection. Finally, we timely summarized the mechanisms of HEV to circumvent the IFN responses. Clarification of the complexity in this battle may provide us new strategies for prevention and antiviral treatment.
authors.affiliation: Center for Diseases Control and Prevention of Guangdong Province , Guangzhou , China .
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Lina
authors.initials: L
authors.lastname: Yi
authors.forename: Changwen
authors.initials: C
authors.lastname: Ke
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ren
authors.initials: R
authors.lastname: Liu
authors.forename: Jinfei
authors.initials: J
authors.lastname: Chen
authors.forename: Hsiang-Fu
authors.initials: HF
authors.lastname: Kung
authors.forename: Ming-Liang
authors.initials: ML
authors.lastname: He
mesh_terms: D004770:Enterovirus / Q000276:immunology*; D004769:Enterovirus Infections / Q000453:epidemiology / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D007370:Interferon Type I / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D007370:Interferon Type I
keywords: Antiviral; host-virus interaction; human enterovirus; interferon respons; viral replication