title: Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia.
abstract: Sickle cell anaemia (SCA) is associated with silent cerebral infarction (SCI), affecting white and cortical grey matter, but there are few data on subcortical volumes. We analysed retrospective magnetic resonance imaging (MRI) data in 26 SCA patients and 20 controls, comparing mean subcortical volumes between three groups: controls, SCA with SCI (n = 13) and SCA without visible abnormality (n = 13). Specific volumetric differences were found in the hippocampus, amygdala, pallidum, caudate, putamen, thalamus, and cerebellum. This is the first study to demonstrate subcortical volume change in SCA, with the most severe volumetric deficits occurring in children with SCI seen on MRI.
authors.affiliation: Imaging & Biophysics Unit, Institute of Child Health, University College London, London, UK.
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Kawadler
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Clayden
authors.forename: Fenella J
authors.initials: FJ
authors.lastname: Kirkham
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Cox
authors.forename: Dawn E
authors.initials: DE
authors.lastname: Saunders
authors.forename: Chris A
authors.initials: CA
authors.lastname: Clark
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000473:pathology; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D020520:Brain Infarction / Q000209:etiology* / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008032:Limbic System / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D012189:Retrospective Studies; D013788:Thalamus / Q000473:pathology; D055815:Young Adult
keywords: magnetic resonance imaging; sickle cell anaemia; sickle cell radiology; stroke