title: 4-Hydroxyphenylpyruvate dioxygenase inhibitors in combination with safeners: solutions for modern and sustainable agriculture.
abstract: Inhibitors of 4-hydroxyphenylpyruvate dioxygenase (HPPD) prevent plant carotenoid pigment formation, which in turn leads to chlorophyll degradation. This "bleaching" herbicide mode of action provides weed-control products for various crops, such as rice, corn, and cereals. Combinations with suitable safeners allow the full exploitation of the potential of this compound class to selectively control major weed problems, including rapidly increasing cases of resistance against other important herbicide classes.
authors.affiliation: Small Molecules Research, Bayer CropScience AG, Industriepark Höchst, 65926 Frankfurt a.M., Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Ahrens
authors.forename: Gudrun
authors.initials: G
authors.lastname: Lange
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
authors.forename: Chris
authors.initials: C
authors.lastname: Rosinger
authors.forename: Lothar
authors.initials: L
authors.lastname: Willms
authors.forename: Andreas
authors.initials: A
authors.lastname: van Almsick
mesh_terms: D015111:4-Hydroxyphenylpyruvate Dioxygenase / Q000037:antagonists & inhibitors*; D000383:Agriculture / Q000639:trends*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006540:Herbicides / Q000737:chemistry* / Q000494:pharmacology; D010858:Pigmentation / Q000187:drug effects; D010944:Plants / Q000187:drug effects; D058728:Weed Control / Q000639:trends
chemical_list: D004791:Enzyme Inhibitors; D006540:Herbicides; D015111:4-Hydroxyphenylpyruvate Dioxygenase
keywords: HPPD inhibitors; crop protection agents; drug discovery; herbicides; safeners