title: Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks.
abstract: DNA double strand breaks (DSBs) constitute one of the most dangerous forms of DNA damage. In actively replicating cells, these breaks are first recognized by specialized proteins that initiate a signal transduction cascade that modulates the cell cycle and results in the repair of the breaks by homologous recombination (HR). Protein signaling in response to double strand breaks involves phosphorylation and ubiquitination of chromatin and a variety of associated proteins. Here we review the emerging structural principles that underlie how post-translational protein modifications control protein signaling that emanates from these DNA lesions.
authors.affiliation: Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
authors.forename: Inbal
authors.initials: I
authors.lastname: Mermershtain
authors.forename: J N Mark
authors.initials: JN
authors.lastname: Glover
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000235:genetics*; D059765:Homologous Recombination / Q000235:genetics / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology
chemical_list: D018797:Cell Cycle Proteins; D009687:Nuclear Proteins
keywords: BRCA1 C-terminal domain; BRCT; BRCT domains; DSB; Double-strand break signaling; FHA domains; FHAf; HR; MRN; Mre11–Rad50–NBS1; OTUB; Phosphorylation signaling; RIDDLE syndrome; UIM; Ubc13; Ubiquitin; double strand break; homologous recombination; orkhead-associated domain.; otubain or ovarian tumor domain protein; radiosensitivity, immunodeficiency, dysmorphic features and learning difficulties; ubiquitin interaction motif
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