title: In-vitro investigation of a potential wave pumping effect in human aorta.
abstract: An impedance pump - also known as Liebau pump - is a simple valveless pump that operates based on the principles of wave propagation and reflection. It has been shown in embryonic zebrafish that a similar mechanism is responsible for the pumping action in the embryonic heart during the early stages before valve formation. Recent studies suggest that the cardiovascular system is designed to take advantage of wave propagation and reflection phenomena in the arterial network. In this study we report the results of an in-vitro study that examines the hypothesis that the adult human aorta acts as a passive pump based on Liebau effect. A hydraulic model with different compliant models of an artificial aorta was used for a series of in-vitro experiments. Our result indicates that wave propagation and reflection can result in a pumping mechanism in a compliant aorta.
authors.affiliation: Option of Bioengineering, Division of Engineering & Applied Sciences, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Niema M
authors.initials: NM
authors.lastname: Pahlevan
authors.forename: Morteza
authors.initials: M
authors.lastname: Gharib
mesh_terms: D001011:Aorta / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012039:Regional Blood Flow
keywords: Aortic waves; Arterial wave reflection; Impedance pump; Left ventricular workload; Liebau effect