title: Novel NGF-potentiating limonoids from the fruits of Melia toosendan.
abstract: Four new limonoids (1-4), together with five known limonoids (5-9), were isolated from the fruits of Melia toosendan. Their structures were elucidated based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, IR, [α](D)). The isolated compounds were evaluated for their neurite outgrowth-promoting activities. Compounds 2 and 6 significantly enhanced NGF-mediated neurite outgrowth in PC12 cells at concentrations ranging from 0.1 to 50.0 μM.
authors.affiliation: Department of Pharmaceutical Science, Shanxi Medical University, No.56 Xinjian South Road, Taiyuan 030001, Shanxi, PR China. Electronic address: zhangqiong_83@hotmail.com.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jian-Kuan
authors.initials: JK
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Ge
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Liang
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Li
authors.forename: Zhi-Da
authors.initials: ZD
authors.lastname: Min
mesh_terms: D000818:Animals; D005638:Fruit; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031585:Melia / Q000737:chemistry*; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000378:metabolism*; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D036701:Limonins; D010936:Plant Extracts; D020932:Nerve Growth Factor
keywords: Limonoid; Melia toosendan; Meliaceae; Neurite outgrowth-promoting activity; Nimbolinin