title: Design and synthesis of novel D-ring fused steroidal heterocycles.
abstract: Using dehydroepiandrosterone as the starting material, we have synthesized a series of steroid analogs possessing a D-ring fused with heterocycles which are pyridine, imidazo [2,1-b]thiazoles or substituted thiazole imines. All the final structures are first reported and identified by NMR and MS spectroscopys, the yields of these products are moderate to good and the reaction conditions are mild. The cytotoxicity of the synthesized compounds against EC-109(human esophageal carcinoma), EC-9706(human esophageal carcinoma), MGC-803(human gastric carcinoma) were investigated.
authors.affiliation: School of Pharmaceutical Sciences and New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, PR China.
authors.forename: Bao-Le
authors.initials: BL
authors.lastname: Zhang
authors.forename: En
authors.initials: E
authors.lastname: Zhang
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Pang
authors.forename: Li-Xing
authors.initials: LX
authors.lastname: Song
authors.forename: Ya-Fei
authors.initials: YF
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Liu
mesh_terms: D003500:Cyclization; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D015195:Drug Design; D054879:Halogenation; D007097:Imines / Q000138:chemical synthesis*; D013844:Thiazoles / Q000138:chemical synthesis*
chemical_list: D007097:Imines; D013844:Thiazoles; D003687:Dehydroepiandrosterone
keywords: Dehydroepiandrosterone; Imidazo [2,1-b]thiazole; Imine