title: The distinct expression patterns of claudin-2, -6, and -11 between human gastric neoplasms and adjacent non-neoplastic tissues.
abstract: BACKGROUND
  Cancers have a multifactorial etiology a part of which is genetic. Recent data indicate that expression of the tight junction claudin proteins is involved in the etiology and progression of cancer.
  
  
  METHODS
  To explore the correlations of the tight junction proteins claudin-2,-6, and -11 in the pathogenesis and clinical behavior of gastric cancer, 40 gastric cancer tissues and 28 samples of non-neoplastic tissues adjacent to the tumors were examined for expression of claudin-2,-6, and -11 by streptavidin-perosidase immunohistochemical staining method.
  
  
  RESULTS
  The positive expression rates of claudin-2 in gastric cancer tissues and adjacent tissues were 25% and 68% respectively (P<0.001). The positive expression rates of claudin-6 in gastric cancer tissues and adjacent tissues were 55% and 79% respectively (P=0.045<0.05). In contrast, the positive expression rates of claudin-11 in gastric cancer tissues and gastric cancer adjacent tissues were 80% and 46% (P=0.004<0.01). Thus in our study, the expression of claudin-2, and claudin-6 was down regulated in gastric cancer tissue while the expression of claudin-11 was up regulated. Correlations between claudin expression and clinical behavior were not observed.
  
  
  CONCLUSIONS
  Our study provides the first evidence that claudin-2,-6, and -11 protein expression varies between human gastric cancers and adjacent non-neoplastic tissues.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5470513569630744.
authors.affiliation: Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Lin
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhijing
authors.initials: Z
authors.lastname: Liu
authors.forename: Qihui
authors.initials: Q
authors.lastname: Liu
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Minlan
authors.initials: M
authors.lastname: Yang
authors.forename: Xiangshu
authors.initials: X
authors.lastname: Jin
authors.forename: Chengshi
authors.initials: C
authors.lastname: Quan
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000556:secondary; D057167:Claudins / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C120453:CLDN11 protein, human; C491875:CLDN2 protein, human; D057167:Claudins; C122101:claudin 6
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