title: Regional, but not total, body composition changes in overweight and obese adults consuming a higher protein, energy-restricted diet are sex specific.
abstract: Secondary analyses of data from 2 studies were used to assess the effects of protein intake and sex on diet-induced changes in body composition. The primary hypothesis was that the changes of body composition via energy restriction (ie, lean body mass [LBM], fat mass [FM], and bone) would be sex and diet specific. For 12 weeks, 43 male (study 1) and 45 female (study 2) overweight and obese adults consumed an energy-deficit diet (750 kcal/d less than energy needs) containing either 0.8 (normal protein [NP], 21 men and 23 women) or 1.4 g protein∙kg(-1)∙d(-1) (high protein [HP], 22 men and 22 women). Body composition measurements were performed at preintervention and postintervention. Over time, all research participants lost weight, LBM, and FM. Independent of protein intake, the men lost more LBM in the trunk (-0.9 vs -0.5 kg) and less in the legs (-1.5 vs -1.1 kg) compared with the women (P < .05). Independent of sex, the HP group lost less LBM in the trunk and legs than the NP group. These sex and protein intake responses resulted in the NP men losing the most LBM in the legs and the NP women losing the most LBM in the trunk. Over time, men lost more FM (-5.0 vs -3.9 kg) from the trunk and less from legs (-1.7 vs -2.1 kg) than women (P < .05), which resulted in a greater decrease of the android-to-gynoid fat ratio for the men. Protein intake did not influence these sex-specific responses or have any independent effects on changes in FM. In addition, protein intake did not influence bone mineral density responses over time; bone mineral density was reduced in women, but not in men. These findings indicate that higher protein intake during weight loss promotes the retention of LBM in both the trunk and legs despite the sex-specific changes in these body regions.
authors.affiliation: Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Minghua
authors.initials: M
authors.lastname: Tang
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Leidy
authors.forename: Wayne W
authors.initials: WW
authors.lastname: Campbell
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D001823:Body Composition; D001825:Body Fluid Compartments; D015519:Bone Density; D001842:Bone and Bones; D031204:Caloric Restriction; D004038:Diet, Reducing; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D002149:Energy Intake; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy*; D050177:Overweight; D012737:Sex Factors; D060726:Torso; D015431:Weight Loss / Q000502:physiology*
chemical_list: D004044:Dietary Proteins
keywords: BMD; BMI; BUN; Body composition; Bone mineral density; DXA; Dietary protein; Energy restriction; FM; HP; LBM; NP; Weight loss; blood urea nitrogen; body mass index; bone mineral density; dual-energy x-ray absorptiometry; fat mass; high-protein diet; lean body mass; normal-protein diet
references.citation: Metabolism. 2001 Apr;50(4):425-35
references.pmid: 11288037
references.citation: J Nutr. 2005 Aug;135(8):1903-10
references.pmid: 16046715
references.citation: Am J Clin Nutr. 2006 Feb;83(2):260-74
references.pmid: 16469983
references.citation: Am J Clin Nutr. 2003 Jun;77(6):1368-73
references.pmid: 12791611
references.citation: J Nutr. 2004 Mar;134(3):568-73
references.pmid: 14988448
references.citation: Int J Obes Relat Metab Disord. 1999 Mar;23(3):312-9
references.pmid: 10193878
references.citation: Am J Clin Nutr. 2005 Nov;82(5):923-34
references.pmid: 16280421
references.citation: J Am Diet Assoc. 1999 Oct;99(10):1228-33
references.pmid: 10524386
references.citation: Obesity (Silver Spring). 2010 Jan;18(1):214-8
references.pmid: 19543208
references.citation: J Nutr. 2004 Mar;134(3):586-91
references.pmid: 14988451
references.citation: J Gerontol A Biol Sci Med Sci. 2010 Oct;65(10):1115-22
references.pmid: 20605872
references.citation: Curr Opin Clin Nutr Metab Care. 2010 Jul;13(4):382-90
references.pmid: 20495453
references.citation: Int J Obes Relat Metab Disord. 2004 Jan;28(1):57-64
references.pmid: 14710168
references.citation: Eur J Clin Nutr. 1999 Jun;53(6):495-502
references.pmid: 10403587
references.citation: Obesity (Silver Spring). 2013 Mar;21(3):E204-10
references.pmid: 23592676
references.citation: J Nutr. 2009 Mar;139(3):514-21
references.pmid: 19158228
references.citation: Nutr Res. 2011 Feb;31(2):104-12
references.pmid: 21419314
references.citation: Am J Clin Nutr. 1998 Oct;68(4):859-65
references.pmid: 9771863
references.citation: Am J Clin Nutr. 1998 Apr;67(4):734-8
references.pmid: 9537621
references.citation: Am J Health Promot. 1993 May-Jun;7(5):342-53
references.pmid: 10148711
references.citation: J Gerontol A Biol Sci Med Sci. 2001 Nov;56(11):M724-30
references.pmid: 11682582
references.citation: Obesity (Silver Spring). 2007 Feb;15(2):421-9
references.pmid: 17299116
references.citation: Am J Clin Nutr. 2001 Sep;74(3):315-21
references.pmid: 11522554
references.citation: Nutr Metab (Lond). 2004 Nov 08;1(1):13
references.pmid: 15533250
references.citation: Am J Clin Nutr. 2003 Jul;78(1):31-9
references.pmid: 12816768
references.citation: J Nutr. 2003 Feb;133(2):411-7
references.pmid: 12566476
references.citation: J Bone Miner Res. 2011 Jun;26(6):1339-48
references.pmid: 21611972
references.citation: J Bone Miner Res. 1998 Jun;13(6):1045-50
references.pmid: 9626637
references.citation: Ann Intern Med. 1998 May 15;128(10):801-9
references.pmid: 9599191
references.citation: Proc Natl Acad Sci U S A. 1918 Dec;4(12):370-3
references.pmid: 16576330
references.citation: Nutr J. 2010 Dec 31;9:72
references.pmid: 21194471
references.citation: Am J Clin Nutr. 2005 Jun;81(6):1298-306
references.pmid: 15941879