title: DW MRI at 3.0 T versus FDG PET/CT for detection of malignant pulmonary tumors.
abstract: Emerging evidence suggests that diffusion-weighted magnetic resonance imaging (DW MRI) could be useful for tumor detection with N and M staging of lung cancer in place of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). DW MRI at 3.0 T and FDG PET/CT were performed before therapy in 113 patients with pulmonary nodules. Mean apparent diffusion coefficient (ADC), maximal standardized uptake value (SUVmax ) and Ki-67 scores were assessed. Quantitatively, specificity and accuracy of ADC (91.7 and 92.9%, respectively) were significantly higher than those of SUVmax (66.7 and 77.9% respectively, p < 0.05), although sensitivity was not significantly different between them (93.5 and 83.1%, p > 0.05). Qualitatively, sensitivity, specificity and accuracy of DW MRI (96.1, 83.3 and 92.0%, respectively) were also not significantly different from that of FDG PET/CT (88.3, 83.3 and 86.7%, respectively, p > 0.05). Significant negative correlation was found between Ki-67 score and ADC (r = -0.66, p < 0.05), ADC and SUVmax (r = -0.37, p < 0.05), but not between Ki-67 score and SUVmax (r = -0.11, p > 0.05). In conclusion, quantitative and qualitative assessments for detection of malignant pulmonary tumors with DW MRI at 3.0 T are superior to those with FDG PET/CT. Furthermore, ADC could predict the malignancy of lung cancer.
authors.affiliation: Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Long-Biao
authors.initials: LB
authors.lastname: Cui
authors.forename: Xing
authors.initials: X
authors.lastname: Tang
authors.forename: Xin-Ling
authors.initials: XL
authors.lastname: Ren
authors.forename: Jie-Ran
authors.initials: JR
authors.lastname: Shi
authors.forename: Hai-Nan
authors.initials: HN
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhi-Kui
authors.initials: ZK
authors.lastname: Li
authors.forename: Chang-Gui
authors.initials: CG
authors.lastname: Wu
authors.forename: Wen
authors.initials: W
authors.lastname: Jian
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Ti
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
mesh_terms: D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: DW MRI; FDG PET/CT; assessment; lung cancer