title: Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
abstract: OBJECTIVE
  Epidemiologic and experimental studies suggest that dietary fat intake may affect risk of pancreatic cancer, but published results are inconsistent.
  
  
  METHODS
  We examined risk associations for specific types of dietary fat intakes and related food sources among 111,416 participants in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We used Cox proportional hazards regression to examine associations between fat intake and pancreatic cancer risk.
  
  
  RESULTS
  Over a mean 8.4 years of follow-up, 411 pancreatic cancer cases were identified. We observed an inverse association between saturated fat intake and pancreatic cancer risk (hazard ratio [HR], 0.64 comparing extreme quintiles; 95% confidence interval [CI], 0.46-0.88), but the association became weaker and nonsignificant when individuals with fewer than 4 years of follow-up were excluded to avoid possible reverse causation (HR, 0.88; 95% CI, 0.58-1.33). Total fat intake showed a similar pattern of association, whereas intakes of monounsaturated and polyunsaturated fats and fats from animal or plant sources showed no associations with risk.
  
  
  CONCLUSIONS
  These results do not support the hypothesis of increased pancreatic cancer risk with higher fat consumption overall or by specific fat type or source. Dietary changes owing to undetected disease may explain the observed inverse association with saturated fat.
authors.affiliation: Department of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, CT, USA. aremhe2@mail.nih.gov
authors.forename: Hannah
authors.initials: H
authors.lastname: Arem
authors.forename: Susan T
authors.initials: ST
authors.lastname: Mayne
authors.forename: Joshua
authors.initials: J
authors.lastname: Sampson
authors.forename: Harvey
authors.initials: H
authors.lastname: Risch
authors.forename: Rachael Z
authors.initials: RZ
authors.lastname: Stolzenberg-Solomon
mesh_terms: D000368:Aged; D015992:Body Mass Index; D016001:Confidence Intervals; D004034:Diet Surveys; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D055088:Early Detection of Cancer; D005247:Feeding Behavior; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D004041:Dietary Fats
keywords: Cohort studies; Dietary fats; Epidemiology; Pancreatic neoplasms
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