title: The G-triplex DNA could function as a new variety of DNA peroxidase.
abstract: This study is the first to investigate the interactions of hemin with a G-triplex DNA of T1 using different DNA binding assays. The low intrinsic peroxidatic activity of hemin could be significantly enhanced using T1. Furthermore, much decreased oxidation enhancement by T2 or T3 with one key guanine mutation was observed, and the observed peroxidatic activity of T1 should be directly due to the G-triplex complexed with hemin.
authors.affiliation: College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei 430072, PR China.
authors.forename: Shaoru
authors.initials: S
authors.lastname: Wang
authors.forename: Boshi
authors.initials: B
authors.lastname: Fu
authors.forename: Shuang
authors.initials: S
authors.lastname: Peng
authors.forename: Xiaoe
authors.initials: X
authors.lastname: Zhang
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D001665:Binding Sites; D001681:Biological Assay; D004247:DNA / Q000737:chemistry*; D021881:DNA, Catalytic; D008954:Models, Biological; D008958:Models, Molecular; D009195:Peroxidase / Q000737:chemistry*
chemical_list: D021881:DNA, Catalytic; C051802:triplex DNA; D004247:DNA; D009195:Peroxidase