title: Synthesis of azomethine imines using an intramolecular alkyne hydrohydrazination approach.
abstract: Azomethine imines can be accessed upon heating appropriate alkynylhydrazide precursors. This simple thermal hydroamination approach allows the formation of five- and six-membered dipoles in modest to excellent yields. The structure of the acyl group is important to minimize side reactions and allow the isolation of the azomethine imines by column chromatography.
authors.affiliation: Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie-Curie, Ottawa, ON, K1N 6N5, Canada.
authors.forename: Ashley D
authors.initials: AD
authors.lastname: Hunt
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dion
authors.forename: Nicolas
authors.initials: N
authors.lastname: Das Neves
authors.forename: Sandrine
authors.initials: S
authors.lastname: Taing
authors.forename: André M
authors.initials: AM
authors.lastname: Beauchemin
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006830:Hydralazine / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001391:Azo Compounds; D007097:Imines; D013882:Thiosemicarbazones; C512188:azomethine; D006830:Hydralazine