title: Acute stress show great influences on liver function and the expression of hepatic genes associated with lipid metabolism in rats.
abstract: BACKGROUND
  The theory of Chinese medicine believes rage harms normal liver function, namely 'raged impairing liver' in short. The purpose of this study is to investigate the impact of acute stress on liver lipid metabolism in rats.
  
  
  RESULTS
  Comparison of liver function indicators, serum lipid level of rats under acute stress and normal rats, as well as detection of liver tissue in the SR - BI, ABCG5 and ABCG8 protein and gene expression changes. Acute stressed rats had shown a lower serum levels of albumin (P<0.01), HDL- cholesterol (P<0.01) than normal rats, with higher serum levels of globulin (P<0.01) and LDL-cholesterol (P<0.05). Acute stressed rat's liver tissue exhibited a lower protein expression of ABCG5 (P<0.05), ABCG8 (P<0.01) and a higher level of SR-BI (P<0.05), compared with to normal rats. Furthermore, liver gene expression of ABCG5 (P<0.01) and ABCG8 (P<0.05) were lower in acute stressed rats than in normal rats, while SR-BI was higher in acute stressed rats than in normal rats (P<0.01).
  
  
  CONCLUSIONS
  Acute stress had a direct influence on rat's liver lipid metabolism.
authors.affiliation: School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Gao
authors.forename: Yuaner
authors.initials: Y
authors.lastname: Zeng
authors.forename: Shuqiang
authors.initials: S
authors.lastname: Liu
authors.forename: Shuling
authors.initials: S
authors.lastname: Wang
mesh_terms: D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D000071019:ATP Binding Cassette Transporter, Subfamily G, Member 8; D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis; D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005786:Gene Expression Regulation; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000096:biosynthesis; D008099:Liver / Q000378:metabolism / Q000503:physiopathology*; D011889:Rage; D051381:Rats; D051122:Scavenger Receptors, Class B / Q000096:biosynthesis; D013315:Stress, Psychological / Q000503:physiopathology*
chemical_list: D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D000071019:ATP Binding Cassette Transporter, Subfamily G, Member 8; D018528:ATP-Binding Cassette Transporters; C480692:Abcg5 protein, rat; C480693:Abcg8 protein, rat; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; C495125:Scarb1 protein, rat; D051122:Scavenger Receptors, Class B
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