title: Nanotechnology for computed tomography: a real potential recently disclosed.
abstract: In the last decade, nanomaterials have gained considerable attention and interest in the development of new and efficient molecular probes for medical diagnosis and imaging. Compared to traditional contrast agents used from the 70s, this comes from the new possibilities offered by the increased half-life of nanosystems in blood stream, as well as by the specific accumulation in organ of lesions through passive or active targeting mechanisms. Heavy metal or iodinated-loaded nanoparticles are excellent absorbers of X-rays and can offer excellent improvement in medical diagnosis and X-ray imaging. This review aims to propose an accurate state-of-the-art of the emerging applications of nanotechnology in X-ray imaging. Likewise we will discuss and compare all the solutions proposed, and the impact of their composition, formulation methods, and physicochemical properties on their applications, efficiency, and potential industrial scaling-up.
authors.affiliation: CNRS 7199, Laboratoire de Conception et Application de Molecules Bioactives, équipe de Pharmacie Biogalénique, Faculte de Pharmacie, University of Strasbourg, 74 route du Rhin, BP, 60024, F 67401 Illkirch Cedex, France, nanton@unistra.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Anton
authors.forename: Thierry F
authors.initials: TF
authors.lastname: Vandamme
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
references.citation: Biochim Biophys Acta. 1985 Mar 29;839(1):1-8
references.pmid: 3978117
references.citation: Contrast Media Mol Imaging. 2007 Mar-Apr;2(2):88-93
references.pmid: 17444558
references.citation: Acad Radiol. 2008 Oct;15(10):1282-90
references.pmid: 18790400
references.citation: Lancet Oncol. 2006 Aug;7(8):657-67
references.pmid: 16887483
references.citation: Biomaterials. 2007 Oct;28(30):4461-8
references.pmid: 17644171
references.citation: J Am Chem Soc. 2007 Jun 20;129(24):7661-5
references.pmid: 17530850
references.citation: Acad Radiol. 2008 Mar;15(3):342-9
references.pmid: 18280932
references.citation: Acad Radiol. 1999 Mar;6(3):176-83
references.pmid: 10898037
references.citation: Chembiochem. 2011 Mar 21;12(5):777-83
references.pmid: 21370375
references.citation: Nucl Instrum Methods Phys Res A. 2007 Oct 1;580(2):968-970
references.pmid: 18836514
references.citation: Nat Mater. 2006 Feb;5(2):118-22
references.pmid: 16444262
references.citation: Cancer Res. 2005 Jun 15;65(12):5231-7
references.pmid: 15958568
references.citation: Acad Radiol. 1999 Jan;6(1):61-5
references.pmid: 9891154
references.citation: Clin Cancer Res. 2001 Feb;7(2):243-54
references.pmid: 11234875
references.citation: Radiology. 1984 Sep;152(3):759-62
references.pmid: 6611564
references.citation: J Pharm Sci. 1996 Sep;85(9):908-14
references.pmid: 8877877
references.citation: Curr Pharm Biotechnol. 2000 Sep;1(2):183-215
references.pmid: 11467336
references.citation: Clin Cancer Res. 1999 Oct;5(10):2918-24
references.pmid: 10537361
references.citation: Radiology. 2009 Feb;250(2):398-406
references.pmid: 19188313
references.citation: Int J Nanomedicine. 2009;4:277-82
references.pmid: 20011244
references.citation: Proc Natl Acad Sci U S A. 2010 May 11;107(19):8760-5
references.pmid: 20410458
references.citation: J Am Chem Soc. 2003 Apr 9;125(14):4253-8
references.pmid: 12670247
references.citation: Bioconjug Chem. 2006 Jul-Aug;17(4):1043-56
references.pmid: 16848414
references.citation: Chemistry. 2009 Dec 14;15(48):13341-7
references.pmid: 19902441
references.citation: Radiology. 1995 Mar;194(3):775-81
references.pmid: 7862978
references.citation: Contrast Media Mol Imaging. 2006 Jul-Aug;1(4):153-64
references.pmid: 17193692
references.citation: J Nucl Med. 2009 May;50(5):667-70
references.pmid: 19372476
references.citation: FEBS Lett. 1980 Sep 22;119(1):43-6
references.pmid: 7428926
references.citation: Acad Radiol. 2010 Apr;17(4):410-7
references.pmid: 20207313
references.citation: Acad Radiol. 2007 Mar;14(3):355-62
references.pmid: 17307669
references.citation: Nature. 1997 Jan 2;385(6611):81-3
references.pmid: 8985251
references.citation: Fortschr Geb Rontgenstrahlen Nuklearmed Erganzungsbd. 1983;118:11-7
references.pmid: 6195966
references.citation: Angew Chem Int Ed Engl. 2009;48(52):9901-4
references.pmid: 19937883
references.citation: Invest Radiol. 2007 Dec;42(12):797-806
references.pmid: 18007151
references.citation: J Med Chem. 1995 Feb 17;38(4):636-46
references.pmid: 7861412
references.citation: Adv Drug Deliv Rev. 2002 Sep 13;54(5):631-51
references.pmid: 12204596
references.citation: Radiology. 1997 May;203(2):465-70
references.pmid: 9114106
references.citation: Nature. 1994 Feb 10;367(6463):532-8
references.pmid: 7509040
references.citation: Acad Radiol. 2003 May;10(5):475-83
references.pmid: 12755534
references.citation: Pharm Res. 2007 Jun;24(6):1193-201
references.pmid: 17373581
references.citation: Nanoscale. 2010 Apr;2(4):582-6
references.pmid: 20644762
references.citation: Biochim Biophys Acta. 1991 Feb 25;1062(2):142-8
references.pmid: 2004104
references.citation: Eur J Med Chem. 2009 Mar;44(3):1155-66
references.pmid: 18760863
references.citation: Mol Pharm. 2009 Mar-Apr;6(2):571-80
references.pmid: 19298061
references.citation: Exp Mol Pathol. 2009 Jun;86(3):215-23
references.pmid: 19186176
references.citation: Eur Radiol. 2009 Oct;19(10):2487-94
references.pmid: 19440717
references.citation: Biomaterials. 2010 Aug;31(24):6249-68
references.pmid: 20510444
references.citation: Chem Rev. 1999 Jul 14;99(7):1665-1688
references.pmid: 11849007
references.citation: Mol Imaging Biol. 2009 Mar-Apr;11(2):128-35
references.pmid: 19067081
references.citation: Urol Oncol. 2008 Jan-Feb;26(1):57-64
references.pmid: 18190833
references.citation: Clin Orthop Relat Res. 2011 Aug;469(8):2179-93
references.pmid: 21344275
references.citation: J Med Chem. 1986 Dec;29(12):2457-65
references.pmid: 3783605
references.citation: Biomaterials. 2013 Jan;34(2):481-91
references.pmid: 23083930
references.citation: Biomaterials. 2010 Sep;31(25):6537-44
references.pmid: 20541800
references.citation: Nano Lett. 2010 Jul 14;10(7):2318-22
references.pmid: 20496900
references.citation: Biomaterials. 2012 Feb;33(4):1107-19
references.pmid: 22061490
references.citation: Small. 2007 Feb;3(2):333-41
references.pmid: 17262759
references.citation: Invest Radiol. 2006 Apr;41(4):384-90
references.pmid: 16523021
references.citation: Mol Imaging. 2005 Apr-Jun;4(2):110-6
references.pmid: 16105509
references.citation: Invest Radiol. 2007 Sep;42(9):652-8
references.pmid: 17700281
references.citation: Int J Pharm. 2010 Oct 15;398(1-2):204-9
references.pmid: 20674723
references.citation: Drug Metab Dispos. 1999 Oct;27(10):1205-13
references.pmid: 10497149
references.citation: Radiology. 2000 Sep;216(3):865-71
references.pmid: 10966724
references.citation: Pharm Res. 2010 Jul;27(7):1408-15
references.pmid: 20424895
references.citation: Nanomedicine. 2009 Mar;5(1):42-5
references.pmid: 18783999
references.citation: Radiology. 1981 Aug;140(2):507-11
references.pmid: 7255729
references.citation: Eur Radiol. 2001;11(4):698-704
references.pmid: 11354769
references.citation: J Control Release. 2008 Jun 24;128(3):185-99
references.pmid: 18374443
references.citation: Langmuir. 2004 Dec 21;20(26):11726-31
references.pmid: 15595804
references.citation: Acad Radiol. 1999 Mar;6(3):164-9
references.pmid: 10898035
references.citation: Invest Radiol. 2001 Jun;36(6):303-8
references.pmid: 11410749
references.citation: Nanotechnology. 2010 Jun 18;21(24):245104
references.pmid: 20498528
references.citation: Pharmacol Rev. 1999 Dec;51(4):691-743
references.pmid: 10581328
references.citation: J Pharmacol Exp Ther. 1984 Apr;229(1):267-75
references.pmid: 6707942
references.citation: AJR Am J Roentgenol. 2006 Feb;186(2):300-7
references.pmid: 16423931
references.citation: Biochim Biophys Acta. 1979 Oct 19;557(1):9-23
references.pmid: 95096
references.citation: Int J Pharm. 2009 Jul 30;377(1-2):142-7
references.pmid: 19454306
references.citation: Br J Radiol. 2006 Mar;79(939):248-53
references.pmid: 16498039
references.citation: Clin Pharmacokinet. 1997 Mar;32(3):180-93
references.pmid: 9084958
references.citation: Biochim Biophys Acta. 1980 Oct 2;601(3):559-71
references.pmid: 6251878
references.citation: Biochim Biophys Acta. 1991 Sep 30;1068(2):133-41
references.pmid: 1911826
references.citation: Biomaterials. 2007 Dec;28(36):5555-61
references.pmid: 17904632
references.citation: Phys Med Biol. 2010 Aug 7;55(15):4389-97
references.pmid: 20647599
references.citation: Invest Radiol. 2006 Mar;41(3):339-48
references.pmid: 16481918
references.citation: Langmuir. 2005 Nov 8;21(23):10644-54
references.pmid: 16262332
references.citation: Adv Healthc Mater. 2012 Jul;1(4):413-31
references.pmid: 23184772
references.citation: Small. 2005 Mar;1(3):325-7
references.pmid: 17193451
references.citation: Annu Rev Phys Chem. 2012;63:493-518
references.pmid: 22475339
references.citation: J Med Chem. 1986 Sep;29(9):1674-82
references.pmid: 3746816
references.citation: J Nucl Med. 2010 May 1;51 Suppl 1:18S-32S
references.pmid: 20457793
references.citation: Thromb Res. 1981 Feb 15-Mar 1;21(4-5):383-90
references.pmid: 7268690
references.citation: Pharm Res. 2011 May;28(5):978-85
references.pmid: 21057856
references.citation: Adv Drug Deliv Rev. 2004 May 7;56(9):1273-89
references.pmid: 15109769
references.citation: Acad Radiol. 1998 Apr;5 Suppl 1:S16-9; discussion S28-30
references.pmid: 9561034
references.citation: J Pharm Sci. 1984 Dec;73(12):1751-5
references.pmid: 6527250
references.citation: J Angiogenes Res. 2010 Mar 05;2:7
references.pmid: 20298533
references.citation: Methods. 2010 Jan;50(1):26-35
references.pmid: 19772922
references.citation: J Control Release. 2000 Mar 1;65(1-2):133-48
references.pmid: 10699277
references.citation: Pharm Res. 2002 Jul;19(7):960-7
references.pmid: 12180548
references.citation: Acad Radiol. 2011 Jan;18(1):20-30
references.pmid: 21145026
references.citation: Biochim Biophys Acta. 1992 Sep 22;1128(1):44-9
references.pmid: 1390877
references.citation: Phys Med Biol. 2008 Oct 7;53(19):R319-50
references.pmid: 18758005
references.citation: Eur J Pharm Biopharm. 2013 Jan;83(1):54-62
references.pmid: 23010566
references.citation: J Pharmacol Exp Ther. 1999 Feb;288(2):665-70
references.pmid: 9918573
references.citation: J Biomed Mater Res. 1996 Jan;30(1):53-65
references.pmid: 8788106
references.citation: Res Commun Chem Pathol Pharmacol. 1985 Nov;50(2):281-90
references.pmid: 2417296
references.citation: PLoS One. 2011;6(9):e25692
references.pmid: 21984939
references.citation: Biochim Biophys Acta. 1981 Dec 23;666(3):493-503
references.pmid: 7034780
references.citation: Br J Radiol. 2011 Jun;84(1002):526-33
references.pmid: 21081567
references.citation: Int J Cancer. 2006 Nov 1;119(9):2236-41
references.pmid: 16841334
references.citation: J Control Release. 2001 Jun 15;73(2-3):137-72
references.pmid: 11516494
references.citation: Adv Drug Deliv Rev. 1999 Apr 5;37(1-3):81-88
references.pmid: 10837728
references.citation: Nanomedicine. 2005 Sep;1(3):193-212
references.pmid: 17292079
references.citation: Can J Physiol Pharmacol. 1987 Feb;65(2):185-90
references.pmid: 2436731
references.citation: J Drug Target. 1997;4(6):381-8
references.pmid: 9239578
references.citation: Biomaterials. 2008 Dec;29(36):4815-22
references.pmid: 18814908
references.citation: Methods. 2010 Jan;50(1):20-5
references.pmid: 19520168
references.citation: J Surg Res. 2004 Jun 1;119(1):41-5
references.pmid: 15126080