title: Development of a new tissue-equivalent material applied to optimizing surgical accuracy.
abstract: The precision of orientation to target placement during invasive therapy is mainly influenced by tool-tissue interaction. In this study, we aim to investigate a transparent Poly (vinyl alcohol) (PVA) hydrogel as tissue-equivalent material which is used in accurate surgical insertion research. The PVA hydrogel with specified formula was prepared by means of physical and chemical crosslink. The effects of chemical composition and synthesis technique on the biomechanical property, density and micro-structure morphology of PVA materials have been investigated in detail. It can be concluded that when PVA concentration is 8 g/dl, the NaCl concentration is 4 wt.%, with mix water/DMSO solvent, prepared under 7 freeze/thaw cycles, the material has the most similar properties with kidney tissue. Experimental results demonstrate that this tissue-equivalent material could be used in the ex vivo insertion accuracy test for robot-assisted percutaneous intervention and surgical training in minimally invasive surgery (MIS).
authors.affiliation: Centre for Advanced Mechanisms and Robotics, School of Mechanical Engineering, Tianjin University, Tianjin 300072, China. shanjmri@tju.edu.cn
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Su
authors.forename: Xingji
authors.initials: X
authors.lastname: Wang
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000494:pharmacology; D007672:Kidney Cortex / Q000187:drug effects / Q000601:surgery / Q000648:ultrastructure; D008422:Materials Testing; D019060:Minimally Invasive Surgical Procedures; D019047:Phantoms, Imaging; D011142:Polyvinyl Alcohol / Q000494:pharmacology*; D012371:Robotics; D013314:Stress, Mechanical; D034421:Sus scrofa; D013718:Tensile Strength / Q000187:drug effects; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011142:Polyvinyl Alcohol
keywords: Deflection; Kidney; Mechanical properties; Polyvinyl alcohol (PVA) hydrogel; Tissue-equivalent material