title: Emerging trends in the discovery of natural product antibacterials.
abstract: This article highlights current trends and advances in exploiting natural sources for the deployment of novel and potent anti-infective countermeasures. The key challenge is to therapeutically target bacterial pathogens that exhibit a variety of puzzling and evolutionarily complex resistance mechanisms. Special emphasis is given to the strengths, weaknesses, and opportunities in the natural product antibacterial drug discovery arena, and to emerging applications driven by advances in bioinformatics, chemical biology, and synthetic biology in concert with exploiting bacterial phenotypes. These efforts have identified a critical mass of natural product antibacterial lead compounds and discovery technologies with high probability of successful implementation against emerging bacterial pathogens.
authors.affiliation: Center for Molecular Discovery, University of New Mexico, Albuquerque, USA; Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
authors.forename: Cristian G
authors.initials: CG
authors.lastname: Bologa
authors.forename: Oleg
authors.initials: O
authors.lastname: Ursu
authors.forename: Tudor I
authors.initials: TI
authors.lastname: Oprea
authors.forename: Charles E
authors.initials: CE
authors.lastname: Melançon
authors.forename: George P
authors.initials: GP
authors.lastname: Tegos
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D001688:Biological Products; D055808:Drug Discovery / Q000639:trends*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products
references.citation: J Am Chem Soc. 2012 Feb 15;134(6):2981-7
references.pmid: 22224500
references.citation: Biochemistry. 2012 Dec 11;51(49):9779-81
references.pmid: 23181847
references.citation: Curr Pharm Des. 2011;17(13):1291-302
references.pmid: 21470111
references.citation: Ann N Y Acad Sci. 2013 Jan;1277:29-53
references.pmid: 23278681
references.citation: J Am Chem Soc. 2011 Nov 16;133(45):18010-3
references.pmid: 21999343
references.citation: Lancet Infect Dis. 2011 May;11(5):381-93
references.pmid: 21530894
references.citation: Curr Opin Microbiol. 2004 Oct;7(5):466-76
references.pmid: 15451501
references.citation: PLoS One. 2011 Apr 04;6(4):e18127
references.pmid: 21483731
references.citation: Antimicrob Agents Chemother. 2012 May;56(5):2314-25
references.pmid: 22314537
references.citation: Appl Environ Microbiol. 2013 Mar;79(6):1882-8
references.pmid: 23315747
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D1130-6
references.pmid: 23193280
references.citation: J Am Chem Soc. 2011 May 18;133(19):7316-9
references.pmid: 21520944
references.citation: Microbiol Mol Biol Rev. 2013 Mar;77(1):112-43
references.pmid: 23471619
references.citation: J Am Chem Soc. 2012 Jan 11;134(1):418-25
references.pmid: 22107593
references.citation: Open Microbiol J. 2013;7:34-52
references.pmid: 23569468
references.citation: Science. 2012 Aug 31;337(6098):1111-5
references.pmid: 22821982
references.citation: Mymensingh Med J. 2011 Jan;20(1):159-64
references.pmid: 21240183
references.citation: Lancet Infect Dis. 2005 Feb;5(2):115-9
references.pmid: 15680781
references.citation: ACS Chem Biol. 2012 Nov 16;7(11):1791-5
references.pmid: 22920239
references.citation: J Antimicrob Chemother. 2012 Dec;67(12):2785-7
references.pmid: 22899807
references.citation: Nat Prod Rep. 2012 Oct;29(10):1074-98
references.pmid: 22802156
references.citation: PLoS One. 2012;7(3):e34064
references.pmid: 22479523
references.citation: BMC Biol. 2013 May 17;11:51
references.pmid: 23683650
references.citation: J Nat Prod. 2012 Mar 23;75(3):311-35
references.pmid: 22316239
references.citation: Nat Biotechnol. 2012 May;30(5):440-6
references.pmid: 22544021
references.citation: Chem Biol. 2012 May 25;19(5):589-98
references.pmid: 22633410
references.citation: Chem Biol. 2012 Nov 21;19(11):1483-95
references.pmid: 23177202
references.citation: Nat Prod Rep. 2013 Jan;30(1):108-60
references.pmid: 23165928
references.citation: Curr Pharm Des. 2013;19(14):2552-60
references.pmid: 23116394
references.citation: J Am Chem Soc. 2012 Dec 5;134(48):19552-5
references.pmid: 23157252
references.citation: Chem Biol. 2012 Oct 26;19(10):1278-87
references.pmid: 23021914
references.citation: Nat Prod Rep. 2011 Oct;28(11):1783-9
references.pmid: 21909580
references.citation: J Bacteriol. 2013 Jan;195(1):167-71
references.pmid: 23104813
references.citation: Chem Biol. 2012 May 25;19(5):559-71
references.pmid: 22633408
references.citation: J Am Chem Soc. 2012 Jul 25;134(29):12259-65
references.pmid: 22741553
references.citation: EMBO Mol Med. 2012 Oct;4(10):1032-42
references.pmid: 22987724
references.citation: Science. 2012 Sep 7;337(6099):1228-31
references.pmid: 22955834
references.citation: Nat Prod Rep. 2012 Oct;29(10):1050-73
references.pmid: 22858605
references.citation: Nucleic Acids Res. 2011 Jul;39(Web Server issue):W339-46
references.pmid: 21672958
references.citation: PLoS Negl Trop Dis. 2011 Nov;5(11):e1411
references.pmid: 22140592
references.citation: Nat Chem Biol. 2011 Dec 15;8(1):6-9
references.pmid: 22173343
references.citation: Methods Enzymol. 2012;517:387-406
references.pmid: 23084949
references.citation: Annu Rev Phytopathol. 2012;50:403-24
references.pmid: 22681451
references.citation: Curr Opin Biotechnol. 2012 Oct;23(5):727-35
references.pmid: 22244790
references.citation: Angew Chem Int Ed Engl. 2011 Oct 4;50(41):9651-4
references.pmid: 21948600
references.citation: Pharmacotherapy. 2010 Nov;30(11):1136-49
references.pmid: 20973687
references.citation: Curr Opin Microbiol. 2005 Oct;8(5):498-503
references.pmid: 16125445