title: Expression of steroidogenic factor 1 and pituitary specific transcription factor 1 in rat pituitary adenomas.
abstract: The protein expressions of steroidogenic factor l (SF-l) and pituitary-specific transcription factor 1 (Pit-1) were investigated immunohistochemically for 53 spontaneous pituitary adenomas of the pars distalis from male Crl:CD(SD) rats. Luteinizing hormone (LH)-positive/prolactin (PRL)-negative and LH-negative/PRL-positive adenomas showed that the expression of SF-1 and Pit-1 was exclusively related to the immunoreactivity of LH and PRL, respectively. All double-positive adenomas (positive for both LH and PRL) were positive for Pit-1 and were supposed to be derived from PRL cells, although some of them also showed SF-1 immunoreactivity. In addition, all null cell adenomas (negative for all anterior pituitary hormones) were positive for SF-1 and negative for Pit-1, indicating that they originated from the gonadotroph cell lineage. This is the first report focusing on the application of transcription factors for the classification of rat pituitary adenomas.
authors.affiliation: Drug Safety Research Laboratories, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yasuno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kandori
authors.forename: Hideki
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Ryo
authors.initials: R
authors.lastname: Fukuda
keywords: pituitary adenoma; pituitary-specific transcription factor 1; rat; steroidogenic factor 1
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