title: Analysis of oxidative stress during the menstrual cycle.
abstract: BACKGROUND
  Few data concerning the oxidative stress (OS) in plasma during the entire menstrual cycle of eumenorrheic women are available.
  
  
  METHODS
  OS was assessed in 20 healthy volunteers during the phase of the menstrual cycle by determining the plasmatic hydroperoxides levels (d-ROMs test). The assessment was performed every three days, starting from the first day (t1) up the end of the menstrual phase (t27). Concomitantly, the estrogen (E2) and progestin (P4) levels were determined at the same time intervals.
  
  
  RESULTS
  From a base value (t1) of 284 +/- 38.0 CARR.U., which is essentially within the normal range (<300 Carratelli units or CARR.U.), the OS levels progressively increased to 378 +/- 115 CARR.U. at t15, and then slightly decreased over the subsequent time but with average values >300 CARR.U. Analysis of the E2 levels showed that the maximum OS values were noticed near the estrogen peak, while remaining above the base levels, and then decreased during the progestin phase until returning to normal at the end of the menstrual cycle.
  
  
  CONCLUSIONS
  It may concludes that the healthy women go into OS for 2/3 of the menstrual cycle.
authors.affiliation: Loyola University School of Medicine-Chicago, Chicago, USA.
authors.forename: Umberto
authors.initials: U
authors.lastname: Cornelli
authors.forename: Gianni
authors.initials: G
authors.lastname: Belcaro
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Cesarone
authors.forename: Annarosa
authors.initials: A
authors.lastname: Finco
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood*; D018384:Oxidative Stress; D011374:Progesterone / Q000097:blood; D017382:Reactive Oxygen Species / Q000097:blood*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D011374:Progesterone; D004958:Estradiol; D008315:Malondialdehyde; D007986:Luteinizing Hormone
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