title: Relationship between oxidative stress parameters and cystatin C levels in patients with severe preeclampsia.
abstract: OBJECTIVE
  Oxidative stress is believed to play a role in the development of preeclampsia (PE). It is known that an increased cystatin C level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and cystatin C levels in patients with severe PE.
  
  
  METHODS
  Forty-four patients with severe PE and 40 healthy pregnant women were recruited for the study. All study subjects were divided into 2 groups: group 1 (n=44) consisted of patients with severe PE, and group 2 (n=40) included healthy pregnant subjects. Blood samples were obtained from all subjects in order to measure the cystatin C level, total antioxidant status, and total oxidant status. The oxidative stress index was calculated.
  
  
  RESULTS
  The group 1 had significantly higher cystatin C, total oxidant status, oxidative stress index levels and lower total antioxidant status level as compared with the group 2 (P=0.001, P<0.001, P<0.001, P=0.036, respectively). The serum cystatin C level was significantly correlated with the oxidative stress index (r=0.609, P<0.001).
  
  
  CONCLUSIONS
  The present study demonstrated that both oxidative stress and cystatin C levels were increased in patients with PE, and the increased cystatin C levels seem to be a consequence of oxidative stress.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Harran University, Turkey.
authors.forename: Saban
authors.initials: S
authors.lastname: Yalcin
authors.forename: Turgay
authors.initials: T
authors.lastname: Ulas
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Eren
authors.forename: Harun
authors.initials: H
authors.lastname: Aydogan
authors.forename: Aysun
authors.initials: A
authors.lastname: Camuzcuoglu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kucuk
authors.forename: Hasan Husnu
authors.initials: HH
authors.lastname: Yuce
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Demir
authors.forename: Mehmet
authors.initials: M
authors.lastname: Vural
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000328:Adult; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D055316:Cystatin C