title: GSTM1 null polymorphisms and oral cancer risk: a meta-analysis.
abstract: Many studies have examined the association between the GSTM1 null gene polymorphism and oral cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. The PubMed and Embase databases were searched for case-control studies published up to May 2013. Data were extracted and pooled odds ratio (OR) with 95% confidence intervals (CI) were calculated. Ultimately, 39 studies, comprising of 4,704 oral cancer cases and 7,090 controls, were included. Overall, for null versus present, the pooled OR was 1.29 (95% CI = 1.20-1.40), and the heterogeneity was found in all studies. In the stratified analysis by ethnicity, significant risks were found among Asians (OR = 1.39, 95% CI = 1.27-1.53; P = 0.000 for heterogeneity), but not in Caucasians (OR = 0.99, 95% CI = 0.83-1.18; P = 0.677 for heterogeneity). In conclusion, this meta-analysis demonstrates that the GSTM1 null gene polymorphism may be an increased risk of oral cancer in Asians but not in Caucasians.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing University Medical School, 30# Zhong Yang Road, Nanjing, 210008, China.
authors.forename: Su-Feng
authors.initials: SF
authors.lastname: Zhao
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Yang
authors.forename: Ming-Xing
authors.initials: MX
authors.lastname: Lu
authors.forename: Guo-Wen
authors.initials: GW
authors.lastname: Sun
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Wang
authors.forename: Yin-Kai
authors.initials: YK
authors.lastname: Zhang
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Pu
authors.forename: En-Yi
authors.initials: EY
authors.lastname: Tang
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D009062:Mouth Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012306:Risk
chemical_list: D005982:Glutathione Transferase
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