title: ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor.
abstract: Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω-transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.
authors.affiliation: Department of Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-Gu, 120-749 Seoul, South Korea. enzymo@yonsei.ac.kr.
authors.forename: Eul-Soo
authors.initials: ES
authors.lastname: Park
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Dong
authors.forename: Jong-Shik
authors.initials: JS
authors.lastname: Shin
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis* / Q000737:chemistry; D055162:Biocatalysis; D015394:Molecular Structure; D011437:Propylamines / Q000737:chemistry / Q000378:metabolism*; D000637:Transaminases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D011437:Propylamines; D000637:Transaminases; C035263:2-propylamine