title: Prognostic significance of mucinous differentiation of endometrioid adenocarcinoma of the endometrium.
abstract: Using Surveillance, Epidemiology, and End Results database we identified 43,882 (97.0%) women with endometrioid adenocarcinomas and 1,374 (3.0%) with mucinous adenocarcinomas. Women with mucinous tumors were older (P < .0001), more often white (P = .04), and more often to present at advanced stage (P = .001). Survival was similar for both histologies; the hazard ratio for cancer-specific survival for mucinous compared to endometrioid tumors was 0.90 (95% CI, 0.74-1.09) while the hazard ratio for overall survival was 0.95 (95% CI, 0.85-1.07). Five-year survival for stage I mucinous tumors was 89.9% (95% CI, 87.6-91.9%) compared to 89.0% (95% CI, 88.6-89.4%) for endometrioid tumors.
authors.affiliation: Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
authors.forename: Vijaya
authors.initials: V
authors.lastname: Galic
authors.forename: Maria B
authors.initials: MB
authors.lastname: Schiavone
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Herzog
authors.forename: Kevin
authors.initials: K
authors.lastname: Holcomb
authors.forename: Sharyn N
authors.initials: SN
authors.lastname: Lewin
authors.forename: Yu-Shiang
authors.initials: YS
authors.lastname: Lu
authors.forename: Alfred I
authors.initials: AI
authors.lastname: Neugut
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Hershman
authors.forename: Jason D
authors.initials: JD
authors.lastname: Wright
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality* / Q000473:pathology*; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000401:mortality* / Q000473:pathology*; D002454:Cell Differentiation; D016889:Endometrial Neoplasms / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D018426:SEER Program
references.citation: J Clin Oncol. 2009 Mar 10;27(8):1214-9
references.pmid: 19171707
references.citation: Cancer. 2006 Feb 15;106(4):812-9
references.pmid: 16400639
references.citation: Hum Pathol. 1995 Nov;26(11):1260-7
references.pmid: 7590702
references.citation: Mod Pathol. 2012 Nov;25(11):1496-507
references.pmid: 22766790
references.citation: Obstet Gynecol. 1980 Feb;55(2):244-7
references.pmid: 6243410
references.citation: Obstet Gynecol. 1996 Dec;88(6):919-26
references.pmid: 8942828
references.citation: J Natl Cancer Inst. 2012 Oct 3;104(19):1503-13
references.pmid: 22923510
references.citation: Am J Surg Pathol. 1983 Dec;7(8):715-29
references.pmid: 6318581
references.citation: Cancer. 1997 Apr 15;79(8):1581-6
references.pmid: 9118042
references.citation: Cancer. 2009 Mar 15;115(6):1276-85
references.pmid: 19204905
references.citation: Gynecol Oncol. 2012 Jun;125(3):541-5
references.pmid: 22410328
references.citation: Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5932-5
references.pmid: 17062663
references.citation: JAMA. 2002 Apr 24;287(16):2106-13
references.pmid: 11966385
references.citation: J Clin Oncol. 2004 Jun 1;22(11):2159-66
references.pmid: 15169803
references.citation: Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1117-21
references.pmid: 10613347
references.citation: Obstet Gynecol. 2010 Mar;115(3):585-590
references.pmid: 20177290
references.citation: Am J Surg Pathol. 2011 Apr;35(4):537-44
references.pmid: 21378544
references.citation: Am J Obstet Gynecol. 2011 Nov;205(5):480.e1-8
references.pmid: 21861962
references.citation: Cancer. 1992 May 1;69(9):2349-60
references.pmid: 1562983
references.citation: Cancer. 1985 Jul 15;56(2):403-12
references.pmid: 4005805
references.citation: Cancer. 2009 Sep 15;115(18):4118-26
references.pmid: 19670446
references.citation: PLoS One. 2012;7(2):e30801
references.pmid: 22383975
references.citation: Cancer. 1998 Dec 15;83(12):2629-37
references.pmid: 9874471