title: Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: a call for standardization.
abstract: Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting-edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well-defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization.
authors.affiliation: Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Hester N
authors.initials: HN
authors.lastname: Blufpand
authors.forename: Nicole
authors.initials: N
authors.lastname: Hes
authors.forename: Arend
authors.initials: A
authors.lastname: Bökenkamp
authors.forename: Marianne D
authors.initials: MD
authors.lastname: van de Wetering
authors.forename: Gertjan J L
authors.initials: GJ
authors.lastname: Kaspers
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007677:Kidney Function Tests; D008991:Monitoring, Physiologic / Q000592:standards*; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy*; D017410:Practice Guidelines as Topic / Q000592:standards*
chemical_list: D000970:Antineoplastic Agents
keywords: adverse effects; chemotherapy induced nephrotoxicity; childhood cancer; dose modifications in case of renal dysfunction; renal function