title: Cogan syndrome presenting after uneventful laser in situ keratomileusis.
abstract: We report 2 cases of Cogan syndrome that developed after uneventful laser in situ keratomileusis. In the first case, an 8-month postoperative biomicroscopy revealed bilateral interface neovascularization, white intrastromal deposits, and anterior chamber cells and flare. In the second case, white cell infiltration and neovascularization were observed in the deep corneal stroma of the patient's right eye 18 months postoperatively. Based on these observations, which are consistent with typical interstitial keratitis, and the patients' history of Meniere-like disease, such as vertigo and mild hearing loss, Cogan syndrome was diagnosed in both patients. Topical steroids were prescribed. Intensive treatments with corneal irrigation and topical steroids showed effective outcomes in both cases.
authors.affiliation: Shinagawa LASIK Center, Chiyoda-ku, Tokyo, Japan. tomita@shinagawa.com
authors.forename: Minoru
authors.initials: M
authors.lastname: Tomita
authors.forename: Ayako
authors.initials: A
authors.lastname: Chiba
authors.forename: Naoko
authors.initials: N
authors.lastname: Inoue
authors.forename: Tukezban
authors.initials: T
authors.lastname: Huseynova
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Tsuru
authors.forename: George O
authors.initials: GO
authors.lastname: Waring
mesh_terms: D000328:Adult; D055952:Cogan Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D016510:Corneal Neovascularization / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D019781:Corneal Topography; D003907:Dexamethasone / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D054018:Lasers, Excimer; D008297:Male; D009883:Ophthalmic Solutions; D011183:Postoperative Complications; D041623:Tomography, Optical Coherence; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids; D009883:Ophthalmic Solutions; C016356:dexamethasone sulfate ester; D003907:Dexamethasone