title: Internal fixation of radiation-induced pathological fractures of the femur has a high rate of failure.
abstract: We investigated the clinical outcome of internal fixation for pathological fracture of the femur after primary excision of a soft-tissue sarcoma that had been treated with adjuvant radiotherapy. A review of our database identified 22 radiation-induced fractures of the femur in 22 patients (seven men, 15 women). We noted the mechanism of injury, fracture pattern and any complications after internal fixation, including nonunion, hardware failure, secondary fracture or deep infection. The mean age of the patients at primary excision of the tumour was 58.3 years (39 to 86). The mean time from primary excision to fracture was 73.2 months (2 to 195). The mean follow-up after fracture fixation was 65.9 months (12 to 205). Complications occurred in 19 patients (86%). Nonunion developed in 18 patients (82%), of whom 11 had a radiological nonunion at 12 months, five a nonunion and hardware failure and two an infected nonunion. One patient developed a second radiation-associated fracture of the femur after internal fixation and union of the initial fracture. A total of 13 patients (59%) underwent 24 revision operations. Internal fixation of a pathological fracture of the femur after radiotherapy for a soft-tissue sarcoma has an extremely high rate of complication and requires specialist attention.
authors.affiliation: Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, Canada. amirsternheim@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Sternheim
authors.forename: K
authors.initials: K
authors.lastname: Saidi
authors.forename: J
authors.initials: J
authors.lastname: Lochab
authors.forename: P W
authors.initials: PW
authors.lastname: O'Donnell
authors.forename: W C
authors.initials: WC
authors.lastname: Eward
authors.forename: A
authors.initials: A
authors.lastname: Griffin
authors.forename: J S
authors.initials: JS
authors.lastname: Wunder
authors.forename: P
authors.initials: P
authors.lastname: Ferguson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004868:Equipment Failure; D005260:Female; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D005500:Follow-Up Studies; D005593:Fracture Fixation, Internal / Q000009:adverse effects* / Q000379:methods; D017102:Fracture Healing; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D005599:Fractures, Ununited / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D011859:Radiography; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012086:Reoperation; D012509:Sarcoma / Q000532:radiotherapy / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000532:radiotherapy / Q000601:surgery; D017211:Treatment Failure
keywords: Femur; Nonunion; Pathologic femur fractures; Radiation-induced complications