title: Nitric oxide-releasing silica nanoparticle-doped polyurethane electrospun fibers.
abstract: Electrospun polyurethane fibers doped with nitric oxide (NO)-releasing silica particles are presented as novel macromolecular scaffolds with prolonged NO-release and high porosity. Fiber diameter (119-614 nm) and mechanical strength (1.7-34.5 MPa of modulus) were varied by altering polyurethane type and concentration, as well as the NO-releasing particle composition, size, and concentration. The resulting NO-releasing electrospun nanofibers exhibited ~83% porosity with flexible plastic or elastomeric behavior. The use of N-diazeniumdiolate- or S-nitrosothiol-modified particles yielded scaffolds exhibiting a wide range of NO release totals and durations (7.5 nmol mg(-1)-0.12 μmol mg(-1) and 7 h to 2 weeks, respectively). The application of NO-releasing porous materials as coatings for subcutaneous implants may improve tissue biocompatibility by mitigating the foreign body response and promoting cell integration.
authors.affiliation: Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
authors.forename: Ahyeon
authors.initials: A
authors.lastname: Koh
authors.forename: Alexis W
authors.initials: AW
authors.lastname: Carpenter
authors.forename: Danielle L
authors.initials: DL
authors.lastname: Slomberg
authors.forename: Mark H
authors.initials: MH
authors.lastname: Schoenfisch
mesh_terms: D001391:Azo Compounds / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D006801:Humans; D057139:Nanofibers / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D001391:Azo Compounds; D001672:Biocompatible Materials; D011140:Polyurethanes; C452539:diazeniumdiolate; D009569:Nitric Oxide; D012822:Silicon Dioxide
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