title: Strategic targeting of multiple water-mediated interactions: a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors.
authors.affiliation: Institute for Chemistry and Biological Chemistry, Zurich University of Applied Sciences-ZHAW, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Fischer
authors.forename: Rainer
authors.initials: R
authors.lastname: Riedl
mesh_terms: D001665:Binding Sites; D015195:Drug Design; D006860:Hydrogen Bonding; D053509:Matrix Metalloproteinase 13 / Q000737:chemistry* / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors / Q000737:chemistry* / Q000378:metabolism; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry*
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D010797:Phthalimides; D014867:Water; C037431:phthalimide; D053509:Matrix Metalloproteinase 13
keywords: chemical biology; matrix metalloproteinase inhibitors; structure-activity relationships; structure-based drug design; water-mediated interactions
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