title: Evaluation of slice accelerations using multiband echo planar imaging at 3 T.
abstract: We evaluate residual aliasing among simultaneously excited and acquired slices in slice accelerated multiband (MB) echo planar imaging (EPI). No in-plane accelerations were used in order to maximize and evaluate achievable slice acceleration factors at 3 T. We propose a novel leakage (L-) factor to quantify the effects of signal leakage between simultaneously acquired slices. With a standard 32-channel receiver coil at 3 T, we demonstrate that slice acceleration factors of up to eight (MB=8) with blipped controlled aliasing in parallel imaging (CAIPI), in the absence of in-plane accelerations, can be used routinely with acceptable image quality and integrity for whole brain imaging. Spectral analyses of single-shot fMRI time series demonstrate that temporal fluctuations due to both neuronal and physiological sources were distinguishable and comparable up to slice-acceleration factors of nine (MB=9). The increased temporal efficiency could be employed to achieve, within a given acquisition period, higher spatial resolution, increased fMRI statistical power, multiple TEs, faster sampling of temporal events in a resting state fMRI time series, increased sampling of q-space in diffusion imaging, or more quiet time during a scan.
authors.affiliation: Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, USA. Electronic address: jxu@umn.edu.
authors.forename: Junqian
authors.initials: J
authors.lastname: Xu
authors.forename: Steen
authors.initials: S
authors.lastname: Moeller
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Auerbach
authors.forename: John
authors.initials: J
authors.lastname: Strupp
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Smith
authors.forename: David A
authors.initials: DA
authors.lastname: Feinberg
authors.forename: Essa
authors.initials: E
authors.lastname: Yacoub
authors.forename: Kâmil
authors.initials: K
authors.lastname: Uğurbil
mesh_terms: D000465:Algorithms; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*
keywords: Blipped CAIPI; Leakage (L-) factor; Residual aliasing; Single-shot fMRI time series; Spectral analysis; g-Factor
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