title: STIM-ORAI interactions that control the CRAC channel.
abstract: The Ca(2+) sensor STIM1 and the Ca(2+) channel ORAI1 are the fundamental working machinery of the CRAC channel, a classical pathway for store-operated Ca(2+) entry. This chapter focuses on the protein-protein interactions of STIM and ORAI proteins that control the channel.
authors.affiliation: La Jolla Institute for Allergy & Immunology, La Jolla, California, USA.
authors.forename: Aparna
authors.initials: A
authors.lastname: Gudlur
authors.forename: Yubin
authors.initials: Y
authors.lastname: Zhou
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Hogan
mesh_terms: D000595:Amino Acid Sequence; D015220:Calcium Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002147:Calmodulin / Q000378:metabolism; D017124:Conserved Sequence; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D009363:Neoplasm Proteins / Q000737:chemistry / Q000378:metabolism*; D000071740:ORAI1 Protein; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D017433:Protein Structure, Secondary; D016511:Severe Combined Immunodeficiency / Q000235:genetics; D000071737:Stromal Interaction Molecule 1
chemical_list: C551025:CRACR2A protein, human; D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C103530:STIM1 protein, human; D000071737:Stromal Interaction Molecule 1
keywords: CRAC channel; CRAC current; ORAI1; ORAI3; STIM1; calcium; gating; interaction; mutation; protein; store-operated calcium entry; structure