title: No Evidence of Human Papillomaviruses in Non-genital Seborrheic Keratosis.
abstract: BACKGROUND
  Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR.
  
  
  OBJECTIVE
  The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR.
  
  
  METHODS
  Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR).
  
  
  RESULTS
  No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type.
  
  
  CONCLUSIONS
  Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects.
authors.affiliation: Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Naser Tayyebi
authors.initials: NT
authors.lastname: Meibodi
authors.forename: Yalda
authors.initials: Y
authors.lastname: Nahidi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Meshkat
authors.forename: Habibollah
authors.initials: H
authors.lastname: Esmaili
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Gharib
authors.forename: Aida
authors.initials: A
authors.lastname: Gholoobi
keywords: Human papillomaviruses; polymerase chain reaction; seborrheic keratosis
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