title: Nine generations of selection for high and low nicotine intake in outbred Sprague-Dawley rats.
abstract: Previous animal studies have revealed significant involvement of genetics in nicotine intake; however, the extent of the genetic contribution to this behavior has not been well addressed. We report the first study of nine generations of selection for high and low voluntary nicotine intake in outbred Sprague-Dawley rats. Bidirectional mass selection resulted in progressively greater nicotine consumption in the high nicotine-preferring line but no decrease in nicotine intake in the low nicotine-preferring line across generations. Our estimated realized heritability for high voluntary nicotine intake is 0.26 vs close to zero for low voluntary nicotine intake. In contrast, we found no differences between the lines across generations for saccharine intake. These selected lines may provide useful animal models for identifying susceptibility and resistance genes and variants for controlling voluntary nicotine intake in rodents, although we recognize that more generations of selection of these two lines and independent replication of our selection for high and low nicotine-preferring lines are needed.
authors.affiliation: Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA.
authors.forename: Tanseli
authors.initials: T
authors.lastname: Nesil
authors.forename: Lutfiye
authors.initials: L
authors.lastname: Kanit
authors.forename: Ming D
authors.initials: MD
authors.lastname: Li
authors.forename: Sakire
authors.initials: S
authors.lastname: Pogun
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014029:Tobacco Use Disorder / Q000235:genetics*
references.citation: Neuron. 2011 Feb 24;69(4):618-27
references.pmid: 21338875
references.citation: Am J Med Sci. 2003 Oct;326(4):168-73
references.pmid: 14557728
references.citation: Pharmacol Biochem Behav. 1989 Jun;33(2):469-75
references.pmid: 2813485
references.citation: Behav Pharmacol. 2008 Sep;19(5-6):435-60
references.pmid: 18690102
references.citation: Behav Brain Res. 2009 Jan 23;196(2):207-13
references.pmid: 18831991
references.citation: Curr Psychiatry Rep. 2006 Apr;8(2):158-64
references.pmid: 16539894
references.citation: Pharmacol Biochem Behav. 1984 Dec;21(6):953-9
references.pmid: 6522421
references.citation: Hum Mol Genet. 2006 Sep 15;15(18):2721-31
references.pmid: 16893910
references.citation: Genes Brain Behav. 2005 Oct;4(7):401-11
references.pmid: 16176386
references.citation: Annu Rev Psychol. 2002;53:435-62
references.pmid: 11752492
references.citation: Behav Genet. 2006 Mar;36(2):248-60
references.pmid: 16482403
references.citation: J Neurosci. 2008 Nov 19;28(47):12318-27
references.pmid: 19020025
references.citation: Eur J Pharmacol. 2000 Dec 27;410(2-3):215-226
references.pmid: 11134671
references.citation: Psychopharmacology (Berl). 2006 Mar;184(3-4):401-8
references.pmid: 16485141
references.citation: J Pharmacol Exp Ther. 1983 Jul;226(1):291-302
references.pmid: 6864548
references.citation: Psychopharmacology (Berl). 1997 Jan;129(1):35-43
references.pmid: 9122361
references.citation: Behav Genet. 2006 Sep;36(5):697-712
references.pmid: 16502134
references.citation: Subst Use Misuse. 2004;39(10-12):1515-69
references.pmid: 15587945
references.citation: Brain Res. 2002 Mar 15;930(1-2):12-20
references.pmid: 11879790
references.citation: Pharmacol Biochem Behav. 1996 Apr;53(4):871-6
references.pmid: 8801591
references.citation: PLoS One. 2012;7(8):e44234
references.pmid: 22937166
references.citation: Pain. 1995 Feb;60(2):125-135
references.pmid: 7784097
references.citation: Hum Mol Genet. 2007 Apr 1;16(7):820-36
references.pmid: 17468183
references.citation: Ann N Y Acad Sci. 2012 Feb;1248:39-70
references.pmid: 22304675
references.citation: J Addict Res Ther. 2012 Jun 1;S2:
references.pmid: 23264883
references.citation: Neuropsychobiology. 2000;41(4):200-4
references.pmid: 10828729
references.citation: Brain Res. 2000 Nov 3;882(1-2):196-200
references.pmid: 11056199
references.citation: Psychol Med. 2004 Jul;34(5):865-79
references.pmid: 15500307
references.citation: Psychopharmacology (Berl). 1980;71(1):45-9
references.pmid: 6779324
references.citation: Psychopharmacology (Berl). 2008 Mar;197(1):45-58
references.pmid: 18040666
references.citation: Nat Rev Genet. 2009 Nov;10(11):783-96
references.pmid: 19834483
references.citation: Trends Mol Med. 2001 Feb;7(2):70-6
references.pmid: 11286758
references.citation: Pharmacol Biochem Behav. 2008 Oct;90(4):525-33
references.pmid: 18513787
references.citation: Pharmacol Biochem Behav. 2012 May;101(3):434-42
references.pmid: 22330674
references.citation: J Neurochem. 2003 Mar;84(6):1431-41
references.pmid: 12614343
references.citation: Eur J Pharmacol. 1995 Jun 6;279(1):59-64
references.pmid: 7556383
references.citation: Genes Brain Behav. 2007 Jul;6(5):401-10
references.pmid: 17010155
references.citation: Mamm Genome. 2001 Jul;12(7):546-53
references.pmid: 11420618
references.citation: Behav Brain Res. 2008 Nov 3;193(1):1-16
references.pmid: 18571741
references.citation: Pharmacol Biochem Behav. 2005 Apr;80(4):577-89
references.pmid: 15820527
references.citation: Pharmacogenomics J. 2007 Apr;7(2):81-98
references.pmid: 17224913
references.citation: Genes Brain Behav. 2009 Nov;8(8):758-71
references.pmid: 19689456
references.citation: Psychopharmacology (Berl). 2011 Apr;214(4):791-804
references.pmid: 21088960
references.citation: Behav Genet. 2005 Jul;35(4):397-406
references.pmid: 15971021
references.citation: Neurobehav Toxicol Teratol. 1983 Mar-Apr;5(2):171-8
references.pmid: 6683362
references.citation: Pharmacol Biochem Behav. 1994 Nov;49(3):531-40
references.pmid: 7862704
references.citation: Pharmacol Biochem Behav. 2007 Feb;86(2):297-305
references.pmid: 17141304
references.citation: Psychopharmacology (Berl). 1998 Nov;140(1):42-51
references.pmid: 9862401
references.citation: Behav Genet. 1993 Mar;23(2):163-70
references.pmid: 8099788
references.citation: Psychol Med. 2004 Oct;34(7):1251-61
references.pmid: 15697051
references.citation: Neuropharmacology. 2011 Jul-Aug;61(1-2):189-201
references.pmid: 21504750
references.citation: Behav Genet. 2011 Jul;41(4):565-70
references.pmid: 21184168