title: Structure of allergens and structure based epitope predictions.
abstract: The structure determination of major allergens is a prerequisite for analyzing surface exposed areas of the allergen and for mapping conformational epitopes. These may be determined by experimental methods including crystallographic and NMR-based approaches or predicted by computational methods. In this review we summarize the existing structural information on allergens and their classification in protein fold families. The currently available allergen-antibody complexes are described and the experimentally obtained epitopes compared. Furthermore we discuss established methods for linear and conformational epitope mapping, putting special emphasis on a recently developed approach, which uses the structural similarity of proteins in combination with the experimental cross-reactivity data for epitope prediction.
authors.affiliation: European Molecular Biology Laboratory, Hamburg Outstation, Hamburg, Germany.
authors.forename: Fabio
authors.initials: F
authors.lastname: Dall'antonia
authors.affiliation: ACIB (Austrian Centre of Industrial Biotechnology), Petersgasse 14, 8010 Graz, Austria; Institute of Molecular Biosciences, University of Graz, Austria.
authors.forename: Tea
authors.initials: T
authors.lastname: Pavkov-Keller
authors.affiliation: Institute of Chemistry, University of Graz, 8010 Graz, Austria.
authors.forename: Klaus
authors.initials: K
authors.lastname: Zangger
authors.affiliation: Institute of Molecular Biosciences, University of Graz, Austria. Electronic address: walter.keller@uni-graz.at.
authors.forename: Walter
authors.initials: W
authors.lastname: Keller
mesh_terms: D000485:Allergens / Q000737:chemistry* / Q000276:immunology; D000818:Animals; D018360:Crystallography, X-Ray; D018604:Epitope Mapping; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011993:Recombinant Fusion Proteins / Q000737:chemistry; D012984:Software
chemical_list: D000485:Allergens; D000939:Epitopes; D011993:Recombinant Fusion Proteins
keywords: Allergen structure; IgE epitope; NMR; Protein family; Structure based epitope prediction; X-ray
references.citation: PLoS One. 2012;7(9):e44850
references.pmid: 22970319
references.citation: Acta Crystallogr D Biol Crystallogr. 2012 Oct;68(Pt 10):1303-10
references.pmid: 22993084
references.citation: Nature. 1989 Dec 21-28;342(6252):877-83
references.pmid: 2687698
references.citation: PLoS Negl Trop Dis. 2011 Apr 19;5(4):e1040
references.pmid: 21526216
references.citation: J Mol Biol. 2012 Jan 27;415(4):635-48
references.pmid: 22100449
references.citation: Structure. 1997 Feb 15;5(2):291-306
references.pmid: 9032083
references.citation: J Biol Chem. 2003 Sep 26;278(39):37730-5
references.pmid: 12851385
references.citation: J Immunol. 2007 Jan 1;178(1):389-96
references.pmid: 17182577
references.citation: Protein Sci. 1996 Apr;5(4):565-77
references.pmid: 8845747
references.citation: J Biol Chem. 2012 Mar 2;287(10):7388-98
references.pmid: 22210776
references.citation: J Immunol. 2004 Oct 15;173(8):5258-67
references.pmid: 15470071
references.citation: J Mol Biol. 1994 Sep 30;242(4):309-20
references.pmid: 7932691
references.citation: J Allergy Clin Immunol. 2010 Apr;125(4):909-917.e4
references.pmid: 20226507
references.citation: J Biol Chem. 1973 May 10;248(9):3313-26
references.pmid: 4700463
references.citation: Annu Rev Plant Physiol Plant Mol Biol. 1996 Jun;47:627-654
references.pmid: 15012303
references.citation: Structure. 1995 Feb 15;3(2):189-99
references.pmid: 7735835
references.citation: J Mol Biol. 2001 Jan 12;305(2):291-305
references.pmid: 11124907
references.citation: Eur J Biochem. 1972 Dec 4;31(2):221-5
references.pmid: 4647176
references.citation: Chem Rev. 2004 Aug;104(8):3623-40
references.pmid: 15303831
references.citation: J Biol Chem. 2008 Aug 15;283(33):22806-14
references.pmid: 18519566
references.citation: Protein Sci. 1993 May;2(5):753-61
references.pmid: 7684291
references.citation: Immunome Res. 2006 Apr 24;2:2
references.pmid: 16635264
references.citation: Endocr Rev. 2008 Dec;29(7):865-97
references.pmid: 18824526
references.citation: Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt 9):1071-3
references.pmid: 20823529
references.citation: Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jan 1;64(Pt 1):25-8
references.pmid: 18097096
references.citation: Structure. 2006 Feb;14(2):185-95
references.pmid: 16472738
references.citation: Crit Rev Food Sci Nutr. 2004;44(5):379-407
references.pmid: 15540651
references.citation: EMBO J. 1986 Feb;5(2):409-13
references.pmid: 2423325
references.citation: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D777-80
references.pmid: 16381978
references.citation: J Allergy Clin Immunol. 2012 Jul;130(1):241-7.e9
references.pmid: 22664167
references.citation: J Allergy Clin Immunol. 2001 Dec;108(6):1045-52
references.pmid: 11742287
references.citation: Proteins. 2006 Oct 1;65(1):40-8
references.pmid: 16894596
references.citation: Biochimie. 2010 Aug;92(8):985-93
references.pmid: 20420880
references.citation: Science. 1990 Dec 14;250(4987):1563-6
references.pmid: 2274788
references.citation: J Mol Recognit. 2008 Jul-Aug;21(4):243-55
references.pmid: 18496882
references.citation: Proteins. 2013 Feb;81(2):300-15
references.pmid: 23011803
references.citation: J Mol Biol. 2005 Sep 2;351(5):1101-9
references.pmid: 16051263
references.citation: Biochemistry. 1992 Jun 9;31(22):5172-6
references.pmid: 1606141
references.citation: Genome Biol. 2005;6(12):242
references.pmid: 16356276
references.citation: J Mol Biol. 2007 Jun 15;369(4):1079-86
references.pmid: 17481656
references.citation: Allergy. 2004 May;59(5):479-81
references.pmid: 15080826
references.citation: Biochemistry. 1990 Feb 13;29(6):1404-12
references.pmid: 2334704
references.citation: J Mol Biol. 2003 Jun 13;329(4):721-30
references.pmid: 12787673
references.citation: J Allergy Clin Immunol. 2007 Feb;119(2):414-20
references.pmid: 17166572
references.citation: Biochem J. 2006 May 1;395(3):463-72
references.pmid: 16372900
references.citation: Plant Cell. 2006 Oct;18(10):2622-34
references.pmid: 16998071
references.citation: Clin Exp Allergy. 2006 Jul;36(7):920-9
references.pmid: 16839408
references.citation: Biochem Soc Trans. 2002 Nov;30(Pt 6):906-10
references.pmid: 12440943
references.citation: Int Arch Allergy Immunol. 2000 Jul;122(3):155-66
references.pmid: 10899758
references.citation: Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1863-9
references.pmid: 11717500
references.citation: J Mol Evol. 1991 Sep;33(3):283-94
references.pmid: 1757999
references.citation: J Mol Biol. 1987 Aug 5;196(3):641-56
references.pmid: 3681970
references.citation: J Allergy Clin Immunol. 2013 Sep;132(3):696-703.e10
references.pmid: 23683465
references.citation: Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12366-71
references.pmid: 9356455
references.citation: Biomol NMR Assign. 2009 Jun;3(1):103-6
references.pmid: 19636957
references.citation: Nucleic Acids Res. 2000 Jan 1;28(1):235-42
references.pmid: 10592235
references.citation: Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):679-88
references.pmid: 11320308
references.citation: Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):366-80
references.pmid: 17327674
references.citation: Biochemistry. 1996 Dec 10;35(49):15672-82
references.pmid: 8961930
references.citation: BMC Bioinformatics. 2009 Sep 14;10:287
references.pmid: 19751513
references.citation: J Mol Biol. 1999 Feb 5;285(5):2177-98
references.pmid: 9925793
references.citation: J Biol Chem. 2009 Jan 30;284(5):3148-3157
references.pmid: 19056737
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3728-33
references.pmid: 19234127
references.citation: Nucleic Acids Res. 2003 Jan 1;31(1):359-62
references.pmid: 12520022
references.citation: Proc Natl Acad Sci U S A. 1981 Jun;78(6):3824-8
references.pmid: 6167991
references.citation: Structure. 1996 Jul 15;4(7):837-52
references.pmid: 8805570
references.citation: Nucleic Acids Res. 2009 Jul;37(Web Server issue):W612-6
references.pmid: 19465377
references.citation: BMC Genomics. 2005 May 29;6:79
references.pmid: 15921533
references.citation: J Immunol. 2005 Sep 15;175(6):3835-45
references.pmid: 16148130
references.citation: Anal Biochem. 2006 Oct 15;357(2):289-98
references.pmid: 16962548
references.citation: J Am Chem Soc. 2010 Jun 30;132(25):8704-19
references.pmid: 20527753
references.citation: J Mol Biol. 1990 Oct 20;215(4):635-51
references.pmid: 2231724
references.citation: J Mol Biol. 1977 Sep 25;115(3):263-77
references.pmid: 592367
references.citation: Protein Sci. 1995 Sep;4(9):1666-9
references.pmid: 8528065
references.citation: Nucleic Acids Res. 2012 Jan;40(Database issue):D343-50
references.pmid: 22086950
references.citation: PLoS One. 2011;6(5):e20020
references.pmid: 21647452
references.citation: Nucleic Acids Res. 2009 Jan;37(Database issue):D233-8
references.pmid: 18838391
references.citation: BMC Immunol. 2006 Apr 07;7:7
references.pmid: 16603068
references.citation: J Mol Biol. 1978 Nov 5;125(3):357-86
references.pmid: 731698
references.citation: J Agric Food Chem. 2008 Jul 9;56(13):5352-8
references.pmid: 18553996
references.citation: Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):880-2
references.pmid: 10089322
references.citation: Biochem J. 1996 Aug 15;318 ( Pt 1):1-14
references.pmid: 8761444
references.citation: Biochemistry. 2003 Dec 2;42(47):13839-47
references.pmid: 14636051
references.citation: J Biol Chem. 1982 Jun 10;257(11):6010-5
references.pmid: 7076661
references.citation: Genes Cells. 2009 Sep;14(9):1055-65
references.pmid: 19678854
references.citation: J Biol Chem. 2001 Mar 23;276(12):9359-65
references.pmid: 11134039
references.citation: Int Arch Allergy Immunol. 1998 Nov;117(3):160-6
references.pmid: 9935306
references.citation: Biochemistry. 1992 Jun 9;31(22):5117-27
references.pmid: 1606135
references.citation: Structure. 1999 Aug 15;7(8):943-52
references.pmid: 10467147
references.citation: J Biol Chem. 2000 Nov 24;275(47):37021-9
references.pmid: 10896943
references.citation: J Mol Biol. 2009 Feb 20;386(2):520-30
references.pmid: 19136006
references.citation: Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W168-71
references.pmid: 15980448
references.citation: J Mol Biol. 1979 Jan 25;127(3):309-38
references.pmid: 430568
references.citation: J Immunol. 2008 Aug 15;181(4):2586-96
references.pmid: 18684949
references.citation: J Agric Food Chem. 2013 Feb 20;61(7):1573-8
references.pmid: 23350842
references.citation: Int Arch Allergy Immunol. 2000 Oct;123(2):99-106
references.pmid: 11060481
references.citation: J Biol Chem. 1982 Jun 10;257(11):6016-22
references.pmid: 7076662
references.citation: J Mol Biol. 2006 Feb 24;356(3):684-94
references.pmid: 16388823
references.citation: J Allergy Clin Immunol. 2011 Oct;128(4):872-879.e8
references.pmid: 21872913
references.citation: Allergy Asthma Proc. 2007 Mar-Apr;28(2):210-5
references.pmid: 17479607
references.citation: Structure. 2010 Aug 11;18(8):1011-21
references.pmid: 20696401
references.citation: J Mol Biol. 2002 Apr 19;318(1):189-97
references.pmid: 12054778
references.citation: J Immunol. 2002 Feb 1;168(3):1267-72
references.pmid: 11801664
references.citation: Structure. 1997 Jan 15;5(1):33-45
references.pmid: 9016715
references.citation: Immunochemistry. 1978 Aug;15(8):609-10
references.pmid: 83294
references.citation: Nat Struct Biol. 1996 Dec;3(12):1040-5
references.pmid: 8946858
references.citation: J Mol Biol. 1980 Aug 25;141(4):441-84
references.pmid: 7003158
references.citation: Perspect Drug Discov Des. 1996;6(1):1-11
references.pmid: 32288275
references.citation: J Mol Biol. 2005 Apr 29;348(2):433-44
references.pmid: 15811379
references.citation: Annu Rev Immunol. 1992;10:97-121
references.pmid: 1591006
references.citation: Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14664-71
references.pmid: 16984999
references.citation: J Immunol. 2011 Jan 1;186(1):333-40
references.pmid: 21123808
references.citation: Acta Crystallogr D Biol Crystallogr. 2009 Nov;65(Pt 11):1206-12
references.pmid: 19923716
references.citation: Protein Eng. 2000 Jan;13(1):67-71
references.pmid: 10679532
references.citation: Bioinformatics. 2008 Jun 15;24(12):1459-60
references.pmid: 18443018
references.citation: Acta Crystallogr B. 1992 Feb 1;48 ( Pt 1):67-75
references.pmid: 1616693
references.citation: J Mol Biol. 2002 Jan 11;315(2):113-20
references.pmid: 11779232
references.citation: Biochemistry. 1985 May 21;24(11):2747-53
references.pmid: 4027223
references.citation: Mol Immunol. 1980 Apr;17(4):519-25
references.pmid: 6156406
references.citation: BMC Bioinformatics. 2011 Aug 17;12:341
references.pmid: 21846404
references.citation: J Allergy Clin Immunol. 2006 Mar;117(3):571-6
references.pmid: 16522455
references.citation: J Mol Biol. 2008 Oct 31;383(1):178-85
references.pmid: 18761353
references.citation: J Immunol. 2003 Sep 15;171(6):3084-90
references.pmid: 12960334
references.citation: J Biochem. 2005 Mar;137(3):255-63
references.pmid: 15809326
references.citation: Plant Mol Biol. 1998 Sep;38(1-2):77-99
references.pmid: 9738961
references.citation: J Mol Biol. 2010 Aug 6;401(1):68-83
references.pmid: 20621650
references.citation: J Comput Aided Mol Des. 1993 Oct;7(5):503-14
references.pmid: 8294943
references.citation: Biochem Biophys Res Commun. 2004 Jan 30;314(1):123-30
references.pmid: 14715255
references.citation: Biochemistry. 1993 Feb 16;32(6):1407-22
references.pmid: 8431421
references.citation: J Allergy Clin Immunol. 2008 Apr;121(4):847-52.e7
references.pmid: 18395549
references.citation: Biotechnol Genet Eng Rev. 1998;15:1-32
references.pmid: 9573603
references.citation: Allergy. 2001;56 Suppl 67:43-4
references.pmid: 11298007
references.citation: Biochemistry. 1997 Sep 9;36(36):10837-45
references.pmid: 9283074
references.citation: J Allergy Clin Immunol. 2000 Aug;106(2):228-38
references.pmid: 10932064
references.citation: Methods. 2004 Mar;32(3):241-8
references.pmid: 14962758
references.citation: Cell Immunol. 2006 Dec;244(2):97-100
references.pmid: 17434469
references.citation: Nature. 1984 Sep 13-19;311(5982):123-6
references.pmid: 6206398
references.citation: Acta Crystallogr D Biol Crystallogr. 2002 Jul;58(Pt 7):1175-81
references.pmid: 12077438
references.citation: J Biol Chem. 1977 Oct 10;252(19):6609-16
references.pmid: 408353
references.citation: J Immunol. 2009 Feb 15;182(4):2141-51
references.pmid: 19201867
references.citation: Pediatr Allergy Immunol. 2001;12 Suppl 14:10-4
references.pmid: 11380891
references.citation: J Immunol. 2006 Apr 15;176(8):4852-60
references.pmid: 16585580
references.citation: Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10037-41
references.pmid: 11517324
references.citation: Protein Sci. 2005 Jan;14(1):246-8
references.pmid: 15576553
references.citation: Annu Rev Immunol. 1984;2:67-101
references.pmid: 6085753
references.citation: Curr Allergy Asthma Rep. 2005 Jan;5(1):74-9
references.pmid: 15659268
references.citation: J Agric Food Chem. 2009 Sep 23;57(18):8643-51
references.pmid: 19694440
references.citation: J Mol Biol. 2002 Jun 21;319(5):1223-34
references.pmid: 12079359
references.citation: J Biol Chem. 2001 Jun 22;276(25):22756-63
references.pmid: 11287426
references.citation: Protein Sci. 2008 Feb;17(2):371-6
references.pmid: 18096638
references.citation: J Biol Chem. 1999 Jan 22;274(4):2337-43
references.pmid: 9891000
references.citation: J Biol Chem. 2004 Sep 10;279(37):39035-41
references.pmid: 15247256
references.citation: Amino Acids. 2007 Sep;33(3):423-8
references.pmid: 17252308
references.citation: Mol Immunol. 2009 May;46(8-9):1796-804
references.pmid: 19251323
references.citation: J Virol. 1985 Sep;55(3):836-9
references.pmid: 2991600
references.citation: J Biol Chem. 2005 Feb 4;280(5):3740-6
references.pmid: 15539389
references.citation: Proteins. 2006 Feb 1;62(2):343-55
references.pmid: 16315316
references.citation: Acta Crystallogr D Biol Crystallogr. 2010 May;66(Pt 5):604-15
references.pmid: 20445236
references.citation: J Biol Chem. 2002 Jun 28;277(26):23684-92
references.pmid: 11953433
references.citation: J Biol Chem. 2012 Oct 5;287(41):34776-85
references.pmid: 22887997
references.citation: Adv Appl Bioinform Chem. 2012;5:11-21
references.pmid: 22888263
references.citation: FEBS J. 2005 Oct;272(20):5182-90
references.pmid: 16218950
references.citation: Immunome Res. 2010 Oct 20;6:6
references.pmid: 20961417
references.citation: Structure. 1997 Jan 15;5(1):19-32
references.pmid: 9016723
references.citation: Proc Natl Acad Sci U S A. 1986 Jan;83(2):226-30
references.pmid: 2417241
references.citation: Biochimie. 2006 Jan;88(1):45-52
references.pmid: 16085352
references.citation: J Biol Chem. 1998 Jan 2;273(1):356-60
references.pmid: 9417088
references.citation: Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Feb 1;61(Pt 2):186-8
references.pmid: 16510989
references.citation: J Mol Biol. 1993 Jul 20;232(2):620-38
references.pmid: 8345526
references.citation: BMC Bioinformatics. 2010 Jul 16;11:381
references.pmid: 20637083
references.citation: J Mol Recognit. 2003 Jan-Feb;16(1):20-2
references.pmid: 12557235
references.citation: Biochem Biophys Res Commun. 2006 Jan 13;339(2):679-86
references.pmid: 16313885
references.citation: Science. 1997 Nov 7;278(5340):1111-4
references.pmid: 9353189
references.citation: J Immunol. 1982 Jul;129(1):212-6
references.pmid: 7086131
references.citation: Structure. 2008 Jan;16(1):125-36
references.pmid: 18184590
references.citation: J Biol Chem. 1996 Nov 1;271(44):27193-6
references.pmid: 8910284
references.citation: Biopolymers. 2008 May;89(5):392-400
references.pmid: 17896349
references.citation: Plant Cell. 1995 Jul;7(7):945-56
references.pmid: 7640527
references.citation: Angew Chem Int Ed Engl. 2003 Feb 24;42(8):864-90
references.pmid: 12596167
references.citation: Biochim Biophys Acta. 2010 Jul;1804(7):1432-42
references.pmid: 20215054
references.citation: J Biol Chem. 2000 Jul 14;275(28):21572-7
references.pmid: 10787420
references.citation: Proteins. 2006 Apr 1;63(1):235-42
references.pmid: 16421930
references.citation: J Mol Biol. 1984 Oct 25;179(2):233-56
references.pmid: 6502713
references.citation: Angew Chem Int Ed Engl. 1999 Jun 14;38(12):1784-1788
references.pmid: 29711196
references.citation: FEBS Lett. 2005 Feb 14;579(5):1208-12
references.pmid: 15710415
references.citation: J Allergy Clin Immunol. 2005 Jan;115(1):163-70
references.pmid: 15637564
references.citation: Nucleic Acids Res. 2012 Jan;40(Database issue):D290-301
references.pmid: 22127870
references.citation: Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):848-51
references.pmid: 17909286
references.citation: Genome Biol. 2005;6(7):226
references.pmid: 15998457
references.citation: Proteins. 2005 Apr 1;59(1):38-48
references.pmid: 15688434
references.citation: Nature. 1992 Nov 12;360(6400):186-8
references.pmid: 1279439
references.citation: Annu Rev Immunol. 1999;17:369-97
references.pmid: 10358763
references.citation: Allergy. 2011 Jul;66(7):878-85
references.pmid: 21255036
references.citation: Structure. 2000 Oct 15;8(10):1025-35
references.pmid: 11080624
references.citation: Nat Protoc. 2006;1(6):2876-90
references.pmid: 17406547
references.citation: J Biol Chem. 2011 Nov 11;286(45):39318-27
references.pmid: 21917921
references.citation: J Protein Chem. 2002 May;21(4):243-53
references.pmid: 12168695
references.citation: Int Arch Allergy Immunol. 2010;152(1):1-11
references.pmid: 19940500
references.citation: Biochemistry. 1992 Sep 22;31(37):8697-705
references.pmid: 1390654
references.citation: Biol Chem. 2008 Jul;389(7):919-23
references.pmid: 18627309
references.citation: Bioinformatics. 2005 Dec 1;21(23):4201-4
references.pmid: 16204345
references.citation: J Mol Recognit. 2006 May-Jun;19(3):200-8
references.pmid: 16598694
references.citation: Angew Chem Int Ed Engl. 2009;48(44):8259-62
references.pmid: 19774576
references.citation: Nature. 1992 Apr 2;356(6368):456-7
references.pmid: 1313552
references.citation: J Struct Biol. 1998 Nov;123(3):265-8
references.pmid: 9878581
references.citation: J Mol Recognit. 2007 Mar-Apr;20(2):113-21
references.pmid: 17421048
references.citation: J Mol Biol. 2001 Apr 27;308(2):263-78
references.pmid: 11327766
references.citation: J Biol Chem. 1984 Nov 10;259(21):13431-5
references.pmid: 6541653
references.citation: J Mol Biol. 2012 Sep 7;422(1):109-23
references.pmid: 22634284
references.citation: Mol Nutr Food Res. 2006 Jul;50(7):638-44
references.pmid: 16764019
references.citation: EMBO J. 2002 Oct 1;21(19):5007-16
references.pmid: 12356717
references.citation: J Biol Chem. 2003 Sep 12;278(37):35524-30
references.pmid: 12840013
references.citation: Biochemistry. 1997 Dec 9;36(49):15073-80
references.pmid: 9398234
references.citation: Nat Struct Biol. 2003 Jun;10(6):482-8
references.pmid: 12740607
references.citation: Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):595-604
references.pmid: 16699186
references.citation: Biochemistry. 1986 Sep 23;25(19):5425-32
references.pmid: 2430611
references.citation: Protein Sci. 2006 Nov;15(11):2558-67
references.pmid: 17001032
references.citation: Protein Sci. 1998 Dec;7(12):2490-8
references.pmid: 9865943
references.citation: Allergy. 2001 Jun;56(6):478-90
references.pmid: 11421891
references.citation: Science. 1990 Aug 17;249(4970):755-9
references.pmid: 1697101
references.citation: J Immunol. 2008 Feb 15;180(4):2313-21
references.pmid: 18250440
references.citation: PLoS One. 2012;7(10):e46435
references.pmid: 23056307
references.citation: J Allergy Clin Immunol. 2002 Jul;110(1):160-6
references.pmid: 12110836
references.citation: Mol Immunol. 2011 Oct;49(1-2):115-23
references.pmid: 21903274
references.citation: J Mol Biol. 2004 Mar 5;336(5):1141-57
references.pmid: 15037075
references.citation: Structure. 1999 Feb 15;7(2):227-36
references.pmid: 10368289
references.citation: Curr Allergy Asthma Rep. 2008 Sep;8(5):425-32
references.pmid: 18682111
references.citation: Bioinformatics. 2003 Jan;19(1):163-4
references.pmid: 12499312
references.citation: J Mol Biol. 2007 May 4;368(3):742-52
references.pmid: 17374540
references.citation: Proteins. 2001 Dec 1;45(4):438-48
references.pmid: 11746691
references.citation: Mol Immunol. 2008 Jul;45(12):3477-89
references.pmid: 18023478
references.citation: Biochem J. 2006 May 15;396(1):41-9
references.pmid: 16483252
references.citation: J Biol Chem. 2010 Aug 13;285(33):25394-401
references.pmid: 20534590
references.citation: J Mol Biol. 1992 Dec 5;228(3):893-908
references.pmid: 1469722
references.citation: Eur J Biochem. 2001 Jun;268(12):3595-604
references.pmid: 11422391
references.citation: Biochemistry. 1998 Sep 15;37(37):12707-14
references.pmid: 9737847
references.citation: Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):753-62
references.pmid: 10089305
references.citation: FEBS Lett. 1998 Nov 6;438(3):272-8
references.pmid: 9827560
references.citation: J Mol Biol. 2007 Jul 20;370(4):714-27
references.pmid: 17543334
references.citation: Allergy. 1978 Feb;33(1):3-14
references.pmid: 77135
references.citation: J Mol Biol. 2008 May 16;378(5):1040-51
references.pmid: 18406424
references.citation: Eur J Biochem. 1999 Dec;266(3):1210-8
references.pmid: 10583419
references.citation: BMC Bioinformatics. 2008 Dec 02;9:514
references.pmid: 19055730
references.citation: J Immunol. 2000 Jul 1;165(1):331-8
references.pmid: 10861069
references.citation: FEBS J. 2005 Jan;272(1):217-27
references.pmid: 15634345
references.citation: J Mol Recognit. 2006 May-Jun;19(3):183-7
references.pmid: 16680720
references.citation: J Mol Biol. 2003 Jan 3;325(1):123-33
references.pmid: 12473456
references.citation: Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7395-400
references.pmid: 12771376
references.citation: Biosci Rep. 2009 Jun;29(3):183-92
references.pmid: 18834331
references.citation: J Biol Chem. 1989 Oct 5;264(28):16620-8
references.pmid: 2777802