title: Association of epicardial fat thickness with TIMI risk score in NSTEMI/USAP patients.
abstract: BACKGROUND
  The association of epicardial adipose tissue (EAT) with coronary artery disease has been shown in previous studies. Furthermore, the relationship between EAT and acute coronary syndrome was studied recently. Herein, we investigated the relationship between EAT thickness and the thrombolysis in myocardial infarction (TIMI) risk score for non-ST-elevation myocardial infarction (NSTEMI) and unstable angina pectoris (USAP).
  
  
  METHODS
  The study included 144 patients with NSTEMI/USAP. The study population was divided into two subgroups according to TIMI risk scores as group I (≤ 4, n = 86) and group II (> 4, n = 58). Stepwise multivariable logistic regression analysis was used to assess the independent association of clinical parameters with TIMI risk score.
  
  
  RESULTS
  EAT thickness was higher in group II than in group I (8.2 ± 2.1 vs. 6.2 ± 2.2, p < 0.001). Moreover, patients in group II had higher rates of multivessel disease and Gensini score (p < 0.001). In univariate linear regression analysis, EAT was positively correlated with TIMI risk score and Gensini score. Multivariate regression analysis showed that EAT thickness (OR: 1.56, 95 % CI: 1.17-2.08, p = 0.003), LVEF (OR: 0.93, 95 % CI: 0.85-0.98, p = 0.03), and Gensini score (OR: 1.36, 95 % CI: 1.24-1.98, p = 0.002) were independently associated with a higher TIMI risk score.
  
  
  CONCLUSIONS
  In conclusion, EAT thickness is independently associated with TIMI risk score and may be an emerging risk factor for adverse events in NSTEMI/USAP patients.
authors.affiliation: Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, 06100, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Ozcan
authors.forename: O
authors.initials: O
authors.lastname: Turak
authors.forename: U
authors.initials: U
authors.lastname: Canpolat
authors.forename: S
authors.initials: S
authors.lastname: Kanat
authors.forename: I
authors.initials: I
authors.lastname: Kadife
authors.forename: S
authors.initials: S
authors.lastname: Avcı
authors.forename: A
authors.initials: A
authors.lastname: Işleyen
authors.forename: M
authors.initials: M
authors.lastname: Cebeci
authors.forename: D
authors.initials: D
authors.lastname: Tok
authors.forename: F N
authors.initials: FN
authors.lastname: Başar
authors.forename: D
authors.initials: D
authors.lastname: Aras
authors.forename: S
authors.initials: S
authors.lastname: Topaloğlu
authors.forename: S
authors.initials: S
authors.lastname: Aydoğdu
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000789:Angina, Unstable / Q000175:diagnosis* / Q000401:mortality*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000401:mortality*; D010496:Pericardium / Q000000981:diagnostic imaging*; D015995:Prevalence; D011859:Radiography; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity; D015996:Survival Rate; D014421:Turkey / Q000453:epidemiology; D014463:Ultrasonography
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