title: Localized salt-dependent aquagenic urticaria: a subtype of aquagenic urticaria?
abstract: Aquagenic urticaria is a rare form of inducible urticaria characterized by wealing at the site of contact of the skin with water, regardless of its temperature, within minutes of exposure. We describe six young women who reported urticarial rashes, triggered mostly by sea bathing, characteristically localized on the inferior facial contours and neck. In four of the six patients, this was the only localization. All six reacted with erythema and wealing to challenge tests with hypertonic saline (3.5% NaCl) applied to the submandibular area and/or neck. Two patients reacted also to tap water or to normal saline, but less intensely. Challenge tests with different hypertonic water solutions, performed in one patient, showed that both salinity and hypertonicity may be pathogenically relevant. Response to antihistamines was poor in three patients. Our experience suggests the existence of a distinct salt-dependent subtype of aquagenic urticaria (SDAU) that affects young women, with a characteristic localization on the inferior facial contours and neck. SDAU is possibly under-recognized and under-reported.
authors.affiliation: Department of Health Sciences (Di.S.Sal), Section of Dermatology, University of Genoa, Genoa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Gallo
authors.forename: M
authors.initials: M
authors.lastname: Gonçalo
authors.forename: E
authors.initials: E
authors.lastname: Cinotti
authors.forename: F
authors.initials: F
authors.lastname: Cecchi
authors.forename: A
authors.initials: A
authors.lastname: Parodi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D012623:Seawater / Q000009:adverse effects*; D012965:Sodium Chloride / Q000009:adverse effects*; D014581:Urticaria / Q000209:etiology*; D014867:Water / Q000009:adverse effects; D055815:Young Adult; D000094482:Chronic Inducible Urticaria
chemical_list: D014867:Water; D012965:Sodium Chloride