title: The effects of advanced paternal age on fertility.
abstract: Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Kovac
authors.forename: Josephine
authors.initials: J
authors.lastname: Addai
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Smith
authors.forename: Robert M
authors.initials: RM
authors.lastname: Coward
authors.forename: Dolores J
authors.initials: DJ
authors.lastname: Lamb
authors.forename: Larry I
authors.initials: LI
authors.lastname: Lipshultz
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D005298:Fertility; D006801:Humans; D008297:Male; D008875:Middle Aged; D010331:Paternal Age
references.citation: Aging Male. 2009 Dec;12(4):100-3
references.pmid: 19883297
references.citation: Mol Psychiatry. 2011 Dec;16(12):1203-12
references.pmid: 21116277
references.citation: JAMA. 2004 Apr 14;291(14):1683-5
references.pmid: 15082678
references.citation: Andrologia. 2007 Apr;39(2):45-50
references.pmid: 17430422
references.citation: Am J Public Health. 2006 May;96(5):862-6
references.pmid: 16571696
references.citation: Nature. 2012 Apr 04;485(7397):246-50
references.pmid: 22495309
references.citation: Hum Reprod. 1998 Feb;13(2):334-8
references.pmid: 9557833
references.citation: Genet Med. 2008 Jun;10(6):457-60
references.pmid: 18496227
references.citation: Nature. 2012 Apr 04;485(7397):242-5
references.pmid: 22495311
references.citation: Fertil Steril. 2009 Nov;92(5):1772-5
references.pmid: 19539905
references.citation: Hum Reprod. 2007 Dec;22(12):3263; author reply 3264
references.pmid: 17947377
references.citation: Br J Cancer. 2002 Feb 1;86(3):356-61
references.pmid: 11875699
references.citation: Andrologia. 1982 Mar-Apr;14(2):164-70
references.pmid: 6808865
references.citation: Fertil Steril. 1996 Aug;66(2):260-4
references.pmid: 8690113
references.citation: Curr Opin Obstet Gynecol. 2012 Jun;24(3):187-93
references.pmid: 22450043
references.citation: Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14952-7
references.pmid: 12397172
references.citation: Fertil Steril. 2001 Feb;75(2):237-48
references.pmid: 11172821
references.citation: Fertil Steril. 1996 May;65(5):1009-14
references.pmid: 8612826
references.citation: Fertil Steril. 2013 Jul;100(1):58-9
references.pmid: 23622887
references.citation: Reprod Biomed Online. 2007 May;14(5):588-92
references.pmid: 17509198
references.citation: Acta Paedopsychiatr. 1968;35(4):100-36
references.pmid: 4880460
references.citation: Reprod Biomed Online. 2007 Nov;15(5):514-9
references.pmid: 18028741
references.citation: Epidemiology. 1999 May;10(3):271-5
references.pmid: 10230837
references.citation: Lancet. 2004 Jul 17-23;364(9430):273-83
references.pmid: 15262106
references.citation: J Androl. 2006 May-Jun;27(3):421-8
references.pmid: 16452528
references.citation: Urology. 2011 Sep;78(3):496-9
references.pmid: 21884897
references.citation: Fertil Steril. 1998 Oct;70(4):625-31
references.pmid: 9797088
references.citation: Fertil Steril. 2011 Jan;95(1):1-8
references.pmid: 20932518
references.citation: Arch Androl. 1994 May-Jun;32(3):197-205
references.pmid: 8074574
references.citation: Int J Epidemiol. 2006 Dec;35(6):1495-503
references.pmid: 17008361
references.citation: Hum Reprod. 1996 Mar;11(3):558-60
references.pmid: 8671265
references.citation: Am J Obstet Gynecol. 2003 Oct;189(4):901-5
references.pmid: 14586322
references.citation: Hum Reprod. 1999 Mar;14(3):731-5
references.pmid: 10221705
references.citation: J Clin Endocrinol Metab. 1982 Oct;55(4):676-81
references.pmid: 6809780
references.citation: Arch Gen Psychiatry. 2008 Sep;65(9):1034-40
references.pmid: 18762589
references.citation: Natl Vital Stat Rep. 2013 Sep;62(3):1-20
references.pmid: 24321416
references.citation: Int J Androl. 1985 Aug;8(4):257-74
references.pmid: 4077284
references.citation: N Engl J Med. 1995 Feb 2;332(5):281-5
references.pmid: 7816062
references.citation: Hum Reprod. 2008 Jun;23(6):1290-6
references.pmid: 18256111
references.citation: Int J Androl. 1980 Jun;3(3):217-28
references.pmid: 7409908
references.citation: Am J Epidemiol. 2010 Jun 15;171(12):1262-9
references.pmid: 20507900
references.citation: J Endocrinol Invest. 1985;8 Suppl 2:87-91
references.pmid: 4031398
references.citation: Birth Defects Res A Clin Mol Teratol. 2007 Jan;79(1):27-34
references.pmid: 17120236
references.citation: BMJ. 1996 Feb 24;312(7029):471-2
references.pmid: 8597677
references.citation: Fertil Steril. 1999 Nov;72(5):803-8
references.pmid: 10560981
references.citation: Int J Epidemiol. 1999 Aug;28(4):711-6
references.pmid: 10480700
references.citation: Fertil Steril. 2012 Aug;98(2):274-83
references.pmid: 22732737
references.citation: Hum Reprod. 1995 May;10(5):1090-7
references.pmid: 7657747
references.citation: Am J Hum Genet. 2001 Nov;69(5):1046-54
references.pmid: 11582569
references.citation: Cancer Epidemiol Biomarkers Prev. 1997 Mar;6(3):151-4
references.pmid: 9138656
references.citation: Natl Vital Stat Rep. 2011 Nov 3;60(1):1-70
references.pmid: 22670489
references.citation: BMC Cancer. 2005 Oct 31;5:143
references.pmid: 16259637
references.citation: Fertil Steril. 2003 Jun;79 Suppl 3:1520-7
references.pmid: 12801554
references.citation: Asian J Androl. 2013 Mar;15(2):179-83
references.pmid: 23334199
references.citation: Lancet. 1955 Aug 13;269(6885):312-3
references.pmid: 13243724
references.citation: Hum Mol Genet. 1994 Aug;3(8):1365-71
references.pmid: 7987316
references.citation: Fertil Steril. 1983 Apr;39(4):530-5
references.pmid: 6832409
references.citation: Am J Obstet Gynecol. 2001 Apr;184(5):818-22; discussion 822-4
references.pmid: 11303188
references.citation: J Assist Reprod Genet. 2009 Jan;26(1):41-6
references.pmid: 19030983
references.citation: Am J Hum Genet. 2012 Feb 10;90(2):175-200
references.pmid: 22325359
references.citation: Urology. 2008 Mar;71(3):490-4
references.pmid: 18342194
references.citation: Hum Reprod. 2000 Aug;15(8):1703-8
references.pmid: 10920089
references.citation: Dan Med Bull. 1990 Jun;37(3):281-2
references.pmid: 2357909
references.citation: Nature. 2012 Aug 23;488(7412):471-5
references.pmid: 22914163
references.citation: BMJ. 1996 Feb 24;312(7029):467-71
references.pmid: 8597676
references.citation: Ann Saudi Med. 1999 May-Jun;19(3):197-200
references.pmid: 17283452
references.citation: Int J Androl. 1996 Jun;19(3):135-42
references.pmid: 8876262
references.citation: Asian J Androl. 2012 Jan;14(1):69-76
references.pmid: 22157982
references.citation: Hum Reprod Update. 2004 Jul-Aug;10(4):327-39
references.pmid: 15192059
references.citation: Arch Androl. 1989;23(3):275-7
references.pmid: 2694997
references.citation: Arch Gen Psychiatry. 2006 Sep;63(9):1026-32
references.pmid: 16953005
references.citation: Am J Hum Genet. 1998 Sep;63(3):711-6
references.pmid: 9718331
references.citation: Hum Reprod Update. 2010 Jan-Feb;16(1):65-79
references.pmid: 19696093
references.citation: Hum Reprod. 1997 May;12(5):1002-5
references.pmid: 9194654
references.citation: Am J Hum Genet. 1987 Aug;41(2):218-48
references.pmid: 3618593
references.citation: J Assist Reprod Genet. 1998 Jul;15(6):359-64
references.pmid: 9673879
references.citation: Am Fam Physician. 2000 Aug 15;62(4):825-32, 837-8
references.pmid: 10969860
references.citation: Obstet Gynecol. 2004 Jan;103(1):51-6
references.pmid: 14704244
references.citation: Fertil Steril. 2003 Dec;80(6):1420-30
references.pmid: 14667878
references.citation: Int J Androl. 1997 Jun;20(3):144-52
references.pmid: 9354183
references.citation: Andrologia. 2002 Sep;34(4):209-17
references.pmid: 12220228
references.citation: J Epidemiol Community Health. 2006 Oct;60(10):851-3
references.pmid: 16973530
references.citation: Fertil Steril. 2008 Jul;90(1):97-103
references.pmid: 17765235
references.citation: Am J Obstet Gynecol. 2004 Aug;191(2):507-14
references.pmid: 15343228
references.citation: J Assist Reprod Genet. 2007 Oct;24(10):437-43
references.pmid: 17768675
references.citation: Am J Mens Health. 2012 Sep;6(5):427-35
references.pmid: 22564913
references.citation: Nature. 2012 Apr 04;485(7397):237-41
references.pmid: 22495306
references.citation: Hum Reprod. 2003 Feb;18(2):447-54
references.pmid: 12571189
references.citation: Hum Reprod. 2007 Jan;22(1):180-7
references.pmid: 17053003
references.citation: Br J Psychiatry. 2003 Nov;183:405-8
references.pmid: 14594914