title: Ascending paresis as presentation of an unusual association between necrotizing autoimmune myopathy and systemic lupus erythematosus.
abstract: A 45 year-old man went to the emergency room due to disease duration of 15 days of insidious onset and progressive course. It began with symmetrical weakness and pain in feet and ankles that extends upward to the knees. Later, this progressed to paraparesis with Creatine phosphokinase levels of 44,270 U/L and respiratory failure that required mechanical ventilation. Electromyography and muscle biopsy of quadriceps were made. The patient responded to corticotherapy in pulses and supporting management. The presentation of ascending paresis suggested the diagnosis of Guillain-Barré syndrome. However, the degree of muscle involvement with rhabdomyolysis explains the neurological damage by itself. The biopsy revealed pathological criteria for necrotizing autoimmune myopathy (NAM), as well as other clinical and laboratory evidence. Patient disease continued and reached criteria for systemic lupus erythematosus (SLE). To our best knowledge, this is the first report of the NAM and SLE association.
authors.affiliation: Departamento de Inmuno-Reumatología, Hospital Nacional Arzobispo Loayza, Lima, Perú
authors.forename: Marco Julio
authors.initials: MJ
authors.lastname: García-Reynoso
authors.affiliation: Facultad de Medicina Humana, Universidad Nacional Mayor de San Marcos (UNMSM), Lima, Perú. Electronic address: veramendi.le@gmail.com.
authors.forename: Liz Eliana
authors.initials: LE
authors.lastname: Veramendi-Espinoza
authors.affiliation: Facultad de Medicina Humana, Universidad Nacional Mayor de San Marcos (UNMSM), Lima, Perú
authors.forename: Henry Jeison
authors.initials: HJ
authors.lastname: Ruiz-Garcia
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications* / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology*; D009135:Muscular Diseases / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D009336:Necrosis / Q000150:complications; D010291:Paresis / Q000209:etiology*
keywords: Guillain-Barre Syndrome; Lupus eritematoso sistémico; Miositis; Myositis; Rabdomiólisis; Rhabdomyolysis; Systemic lupus erythematosus; Síndrome de Guillain-Barré