title: An analysis of 372 patients with anterior uveitis in a large Ibero-American cohort of spondyloarthritis: the RESPONDIA Group.
abstract: OBJECTIVE
  This study analysed the frequency of anterior uveitis (AU) and its correlations in a large cohort of patients with spondyloarthritis (SpA).
  
  
  METHODS
  A common protocol of investigation was prospectively applied to 2012 SpA patients in 85 centres from 10 Ibero-American countries. Clinical and demographic variables and disease indexes were investigated. Categorical variables were compared by χ2 and Fisher's exact test, and continuous variables were compared by ANOVA or Kruskal-Wallis test. A value of p<0.05 was considered significant.
  
  
  RESULTS
  AU was referred by 372 SpA patients (18.5%). AU was statistically associated with inflammatory low back pain (p<0.001), radiographic sacroiliitis (p<0.001), enthesopathies (p=0.004), urethritis/acute diarrhoea (p<0.001), balanitis (p=0.002), hip involvement (p=0.002), HLA-B27 (p=0.003), and higher C-reactive protein (p=0.001), whilst it was negatively associated with the number of painful (p=0.03) and swollen (p=0.005) peripheral joints, psoriatic arthritis (p<0.001), psoriasis (p<0.001), nail involvement (p<0.001), and dactilitis (p=0.062; trend). No association with gender, race, and indices (disease activity, functionality and quality of life) was observed. Logistic regression showed that ankylosing spondylitis (p=0.001) and HLA-B27 (p=0.083; trend) was significantly associated with AU, while extra-articular manifestations (predominantly psoriasis) were negatively associated (p=0.016).
  
  
  CONCLUSIONS
  Anterior uveitis is a frequent extra-articular manifestation in SpA patients, positively associated with axial involvement and HLA-B27 and negatively associated with peripheral involvement and psoriatic arthritis.
authors.affiliation: Disciplina de Reumatologia, Universidade de São Paulo, Brazil. pdsampaiobarros@uol.com.br
authors.forename: Percival D
authors.initials: PD
authors.lastname: Sampaio-Barros
authors.forename: Ivanio A
authors.initials: IA
authors.lastname: Pereira
authors.forename: Claudia
authors.initials: C
authors.lastname: Hernández-Cuevas
authors.forename: Alberto
authors.initials: A
authors.lastname: Berman
authors.forename: Ruben
authors.initials: R
authors.lastname: Burgos-Vargas
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Gutierrez
authors.forename: Anabela
authors.initials: A
authors.lastname: Barcelos
authors.forename: José E
authors.initials: JE
authors.lastname: Chávez-Corrales
authors.forename: Mario
authors.initials: M
authors.lastname: Moreno
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Palleiro
authors.forename: Ricardo
authors.initials: R
authors.lastname: Saénz-Castro
authors.forename: Ivan
authors.initials: I
authors.lastname: Stekman
authors.forename: Valderilio F
authors.initials: VF
authors.lastname: Azevedo
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Braga-da-Silva
authors.forename: Gustavo
authors.initials: G
authors.lastname: Citera
authors.forename: Diana
authors.initials: D
authors.lastname: Flores-Alvarado
authors.forename: Célio R
authors.initials: CR
authors.lastname: Gonçalves
authors.forename: César
authors.initials: C
authors.lastname: Graf
authors.forename: Alejandro
authors.initials: A
authors.lastname: Nitsche
authors.forename: Jorge
authors.initials: J
authors.lastname: Saavedra
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Ximenes
authors.forename: Janitzia
authors.initials: J
authors.lastname: Vázquez-Mellado
authors.forename: Eduardo
authors.initials: E
authors.lastname: Collantes-Estevez
mesh_terms: D000293:Adolescent; D000328:Adult; D002489:Central America / Q000453:epidemiology; D005260:Female; D015796:HLA-B27 Antigen / Q000378:metabolism*; D006801:Humans; D007596:Joints / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D011565:Psoriasis / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology; D012042:Registries / Q000706:statistics & numerical data; D013020:South America / Q000453:epidemiology; D025241:Spondylarthritis / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology; D014606:Uveitis, Anterior / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D015796:HLA-B27 Antigen