title: Current status and prospects for development of a vaccine against Trichomonas vaginalis infections.
abstract: Trichomonas vaginalis is a sexually transmitted pathogen with an annual worldwide incidence of over 276 million infections, the highest of all curable and non-viral STI. A large proportion of cases are asymptomatic and under-diagnosed with conventional diagnostic tools. Infection has important maternal and fetal health consequences and can lead to a higher probability of HIV transmission and susceptibility. Lack of affordable accurate diagnostic tests globally and metronidazole resistance hinder T. vaginalis control efforts. Based on data from current vaccination studies in animal models, a human vaccine is achievable to intervene on the substantial incidence of infection.
authors.affiliation: University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Smith
authors.affiliation: University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Division of Infectious Disease and Public Health Ontario, Ottawa, ON, Canada. Electronic address: ggarber@ohri.ca.
authors.forename: Gary E
authors.initials: GE
authors.lastname: Garber
mesh_terms: D000818:Animals; D005260:Female; D015658:HIV Infections / Q000635:transmission; D006801:Humans; D008297:Male; D014247:Trichomonas Vaginitis / Q000517:prevention & control*; D014246:Trichomonas vaginalis; D014611:Vaccination / Q000639:trends; D014612:Vaccines
chemical_list: D014612:Vaccines
keywords: HIV susceptibility; Immune response; Trichomonas vaginalis; Vaccine development; Vaginitis