title: Scalable graphene field-effect sensors for specific protein detection.
abstract: We demonstrate that micron-scale graphene field-effect transistor biosensors can be fabricated in a scalable fashion from large-area chemical vapor deposition derived graphene. We electrically detect the real-time binding and unbinding of a protein biomarker, thrombin, to and from aptamer-coated graphene surfaces. Our sensors have low background noise and high transconductance, comparable to exfoliated graphene devices. The devices are reusable and have a shelf-life greater than one week.
authors.affiliation: Department of Physics, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Grant
authors.initials: G
authors.lastname: Saltzgaber
authors.forename: Peter
authors.initials: P
authors.lastname: Wojcik
authors.forename: Tal
authors.initials: T
authors.lastname: Sharf
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Leyden
authors.forename: Jenna L
authors.initials: JL
authors.lastname: Wardini
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Heist
authors.forename: Adeniyi A
authors.initials: AA
authors.lastname: Adenuga
authors.forename: Vincent T
authors.initials: VT
authors.lastname: Remcho
authors.forename: Ethan D
authors.initials: ED
authors.lastname: Minot
mesh_terms: D052157:Aptamers, Nucleotide / Q000378:metabolism; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D013499:Surface Properties; D013917:Thrombin / Q000032:analysis* / Q000378:metabolism; D014173:Transistors, Electronic
chemical_list: D052157:Aptamers, Nucleotide; D006108:Graphite; D013917:Thrombin