title: Ace I/D polymorphism is associated with habitual physical activity in pubertal boys.
abstract: We investigated the association between the angiotensin I-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and physical activity levels in boys at early pubertal stage (calendar age 12.04 ± 0.77 years). Body composition by DXA, pubertal stage and cardiovascular fitness on cycle ergometer were measured in addition to 7-day accelerometry. DNA was separated from the whole blood. Sedentary behaviour level was significantly lower in DD subjects compared to I allele carriers. A significant main effect of the D allele was found on total physical activity (F 1,256 = 5,453; p = 0.020; η (2) = 0.021] and on light physical activity (F 1,256 = 4.74; p = 0.030; η (2) = 0.018). Adding screen time as a covariate did not change ACE I/D polymorphism effect on total physical activity levels (F 2,256 = 3,326; p = 0.041; η (2) = 0.025). Carriers of the D allele had significantly higher light physical activity (F 1,256 = 4,710; p = 0.031; η (2) = 0.20), with screen time as covariate. In conclusion, ACE gene has a significant effect on sedentary, light and total physical activity levels in healthy 12-year-old boys.
authors.affiliation: Department of Coaching Sciences, Centre of Social, Behavioural and Health Sciences, University of Tartu, Ravila 14a, 50411, Tartu, Estonia, jarek.maestu@ut.ee.
authors.forename: Jarek
authors.initials: J
authors.lastname: Mäestu
authors.forename: Evelin
authors.initials: E
authors.lastname: Lätt
authors.forename: Triin
authors.initials: T
authors.lastname: Rääsk
authors.forename: Katrin
authors.initials: K
authors.lastname: Sak
authors.forename: Kariina
authors.initials: K
authors.lastname: Laas
authors.forename: Jaak
authors.initials: J
authors.lastname: Jürimäe
authors.forename: Toivo
authors.initials: T
authors.lastname: Jürimäe
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D006801:Humans; D008297:Male; D009043:Motor Activity; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011627:Puberty / Q000502:physiology; D057185:Sedentary Behavior
chemical_list: D007703:Peptidyl-Dipeptidase A
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