title: Synthesis of 24-phenyl-24-oxo steroids derived from bile acids by palladium-catalyzed cross coupling with phenylboronic acid. NMR characterization and X-ray structures.
abstract: Palladium-catalyzed cross coupling of phenyboronic acid with acetylated bile acids in which the carboxyl functions have been activated by formation of a mixed anhydride with pivalic anhydride afforded moderate to good yield of 24-phenyl-24-oxo-steroids. Unambiguous assignments of the NMR signals were made with the aid of combined 1D and 2D NMR techniques. X-ray diffraction studies confirmed the obtained structures.
authors.affiliation: Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México, DF, México.
authors.forename: Martha C
authors.initials: MC
authors.lastname: Mayorquín-Torres
authors.forename: Margarita
authors.initials: M
authors.lastname: Romero-Ávila
authors.forename: Marcos
authors.initials: M
authors.lastname: Flores-Álamo
authors.forename: Martin A
authors.initials: MA
authors.lastname: Iglesias-Arteaga
mesh_terms: D001647:Bile Acids and Salts / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D018360:Crystallography, X-Ray; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001647:Bile Acids and Salts; D001897:Boronic Acids; D007659:Ketones; D013256:Steroids; D010165:Palladium; C010686:benzeneboronic acid
keywords: 24-Phenyl-24-oxo steroids; Bile acids; Palladium-catalyzed cross coupling; Phenylboronic acid