title: Hyalinizing clear cell carcinoma of the parotid gland: report of a recurrent case with aggressive cytomorphology and behavior diagnosed on fine-needle cytology sample.
abstract: A case of recurrent hyalinizing clear cell carcinoma (HCCC) of the parotid gland in a 46-year-old female is here introduced. The patient had undergone a left superficial parotidectomy 6 months ago in another institution for an alleged benign, circumscribed mass 2.4 cm in diameter of the left parotid gland. Histopathological examination revealed a poorly differentiated HCCC bearing a EWSR-1 translocation on FISH examination. Fine Needle Cytology (FNC) was performed on three separate soft tissue masses in the pre-masseterine area and a cytological diagnosis of recurrent, poorly differentiated, possibly aggressive variant of HCCC, was rendered. FISH performed on a destained Diff Quik stained smear demonstrated an ESWR-1 translocation, which supported the cytopathological diagnosis. The cytomorphologic features and the differential diagnosis of this aggressive variant of HCCC are briefly discussed.
authors.affiliation: S.S.D. di Citopatologia, S.C. di Anatomia Patologica e Citopatologia, Naples, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Fulciniti
authors.forename: Maria
authors.initials: M
authors.lastname: Pia Curcio
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Liguori
authors.forename: Gabriella
authors.initials: G
authors.lastname: Aquino
authors.forename: Gerardo
authors.initials: G
authors.lastname: Botti
authors.forename: Anna Cipolletta
authors.initials: AC
authors.lastname: Campanile
authors.forename: Rossella
authors.initials: R
authors.lastname: De Cecio
authors.forename: Ettore
authors.initials: E
authors.lastname: Pavone
authors.forename: Corrado
authors.initials: C
authors.lastname: Aversa
authors.forename: Francesco
authors.initials: F
authors.lastname: Perri
authors.forename: Francesco
authors.initials: F
authors.lastname: Caponigro
authors.forename: Franco
authors.initials: F
authors.lastname: Ionna
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010307:Parotid Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D035583:Rare Diseases; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor; C526516:cytokeratin MNF116, human; D007633:Keratins
keywords: Fine needle cytology; aggressive tumors of salivary glands; carcinoma of the parotid gland; hyalinizing clear cell; rare salivary gland tumors; salivary gland tumors