title: Comorbid depression in heart failure.
abstract: Heart failure (HF) is highly prevalent and associated with adverse outcomes and high costs. Compared with the general population, depression is up to five times more common in HF patients. Comorbid depression increases morbidity and mortality risk and health-care expenditures even further and decreases quality of life. Possible, often interrelated, mediators of these effects include biological, behavioral, and psychosocial factors. Screening instruments such as the self-administered PHQ-2 facilitate detection of patients at risk. Although antidepressants may improve psychological well-being, no positive effects on hard clinical endpoints have been demonstrated to date.
authors.affiliation: Department of Internal Medicine I, University Hospital and University of Würzburg, Würzburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Wallenborn
authors.forename: C E
authors.initials: CE
authors.lastname: Angermann
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D019317:Evidence-Based Medicine; D006333:Heart Failure / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D015995:Prevalence; D012307:Risk Factors
chemical_list: D000928:Antidepressive Agents
references.citation: Am J Med. 2000 Jan;108(1):2-8
references.pmid: 11059434
references.citation: J Am Coll Cardiol. 2001 Jul;38(1):199-205
references.pmid: 11451275
references.citation: Eur J Heart Fail. 2002 Aug;4(4):541-51
references.pmid: 12167395
references.citation: Heart Lung. 2012 Sep-Oct;41(5):469-83
references.pmid: 22938627
references.citation: Int J Cardiol. 2013 Jul 31;167(2):502-7
references.pmid: 22341693
references.citation: J Am Coll Cardiol. 2004 May 5;43(9):1542-9
references.pmid: 15120809
references.citation: Arch Intern Med. 2007 Feb 26;167(4):367-73
references.pmid: 17325298
references.citation: Circ Heart Fail. 2012 Jan;5(1):25-35
references.pmid: 21956192
references.citation: Heart. 2007 Sep;93(9):1137-46
references.pmid: 17699180
references.citation: Brain Behav Immun. 2003 Apr;17(2):69-85
references.pmid: 12676570
references.citation: Psychosom Med. 2005 May-Jun;67 Suppl 1:S37-41
references.pmid: 15953799
references.citation: Psychiatry Res. 1997 Jan 15;66(1):1-11
references.pmid: 9061799
references.citation: Neurosci Biobehav Rev. 2002 Dec;26(8):941-62
references.pmid: 12667498
references.citation: J Card Fail. 2005 Aug;11(6):455-63
references.pmid: 16105637
references.citation: Gen Hosp Psychiatry. 2011 May-Jun;33(3):203-16
references.pmid: 21601716
references.citation: Psychosom Med. 2004 May-Jun;66(3):305-15
references.pmid: 15184688
references.citation: Cochrane Database Syst Rev. 2012 Sep 12;(9):CD002752
references.pmid: 22972058
references.citation: Eur J Heart Fail. 2003 Jun;5(3):399-400
references.pmid: 12798840
references.citation: J Am Coll Cardiol. 2005 May 17;45(10):1654-64
references.pmid: 15893183
references.citation: J Am Coll Cardiol. 2010 Aug 24;56(9):692-9
references.pmid: 20723799
references.citation: Int J Cardiol. 2012 Nov 29;161(3):143-50
references.pmid: 21982700
references.citation: J Psychosom Res. 2005 Feb;58(2):163-71
references.pmid: 15820844
references.citation: Psychosom Med. 2004 Mar-Apr;66(2):165-73
references.pmid: 15039500
references.citation: Psychosom Med. 2005 May-Jun;67 Suppl 1:S29-33
references.pmid: 15953797
references.citation: Arch Intern Med. 2002 Sep 9;162(16):1860-6
references.pmid: 12196084
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2005 Feb;29(2):201-17
references.pmid: 15694227
references.citation: Eur J Heart Fail. 2007 Oct;9(10):1018-23
references.pmid: 17660002
references.citation: Int J Cardiol. 2011 Feb 17;147(1):66-73
references.pmid: 19716613
references.citation: Histopathology. 2007 Apr;50(5):535-46
references.pmid: 17394488
references.citation: Eur Heart J. 2002 Jan;23(2):139-46
references.pmid: 11785996
references.citation: Circ Heart Fail. 2013 May;6(3):387-94
references.pmid: 23512984
references.citation: Biol Psychiatry. 2007 Aug 15;62(4):302-8
references.pmid: 17210140
references.citation: J Card Fail. 2009 May;15(4):286-292.e2
references.pmid: 19398075
references.citation: Circulation. 2009 Jul 14;120(2):134-40, 3p following 140
references.pmid: 19564557
references.citation: JAMA. 2012 Aug 1;308(5):465-74
references.pmid: 22851113
references.citation: J Am Geriatr Soc. 2007 Oct;55(10):1585-91
references.pmid: 17714458
references.citation: J Am Coll Cardiol. 2006 Oct 17;48(8):1527-37
references.pmid: 17045884
references.citation: Psychother Psychosom. 2004 Nov-Dec;73(6):386-90
references.pmid: 15479995
references.citation: Am J Cardiol. 2011 Feb 15;107(4):545-51
references.pmid: 21295172
references.citation: Neuropsychobiology. 1990-1991;24(3):115-20
references.pmid: 2135065
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):769-83
references.pmid: 20561554
references.citation: J Am Coll Cardiol. 2005 Mar 1;45(5):637-51
references.pmid: 15734605
references.citation: J Am Geriatr Soc. 2010 Aug;58(8):1441-8
references.pmid: 20533964
references.citation: Arch Intern Med. 2008 Feb 11;168(3):316-24
references.pmid: 18268174
references.citation: J Affect Disord. 1992 Mar;24(3):183-92
references.pmid: 1573127
references.citation: Circulation. 2008 Oct 21;118(17):1768-75
references.pmid: 18824640
references.citation: Arch Intern Med. 2001 Aug 13-27;161(15):1849-56
references.pmid: 11493126
references.citation: Arch Intern Med. 2008 Nov 10;168(20):2232-7
references.pmid: 19001200
references.citation: Int J Cardiol. 2010 Jul 9;142(2):133-7
references.pmid: 19162345
references.citation: Am J Prev Med. 2002 Jul;23(1):51-61
references.pmid: 12093424
references.citation: J Am Coll Cardiol. 2010 Apr 27;55(17):1837-43
references.pmid: 20413035
references.citation: J Am Coll Cardiol. 2004 Dec 21;44(12):2333-8
references.pmid: 15607395
references.citation: Clin Res Cardiol. 2013 Apr;102(4):269-78
references.pmid: 23262494
references.citation: Patient Educ Couns. 2006 Feb;60(2):187-93
references.pmid: 16253468
references.citation: Eur J Heart Fail. 2007 Dec;9(12):1212-22
references.pmid: 18029292
references.citation: N Engl J Med. 1996 May 30;334(22):1441-7
references.pmid: 8618584
references.citation: Int J Cardiol. 2011 Jan 7;146(1):64-7
references.pmid: 20188426
references.citation: Am Heart J. 2007 Jul;154(1):102-8
references.pmid: 17584561
references.citation: Expert Opin Investig Drugs. 2005 May;14(5):567-77
references.pmid: 15926864
references.citation: Eur Heart J. 2012 Jul;33(14):1787-847
references.pmid: 22611136