title: Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders.
abstract: BACKGROUND
  Autism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, we have investigated changes in protein biomarkers in blood during childhood and adolescent development.
  
  
  METHODS
  We carried out a multiplex immunoassay profiling analysis of serum samples from 37 individuals with a diagnosis of ASD and their matched, non-affected siblings, aged between 4 and 18 years, to identify molecular pathways affected over the course of ASDs.
  
  
  RESULTS
  This analysis revealed age-dependent differences in the levels of 12 proteins involved in inflammation, growth and hormonal signaling.
  
  
  CONCLUSIONS
  These deviations in age-related molecular trajectories provide further insight into the progression and pathophysiology of the disorder and, if replicated, may contribute to better classification of ASD individuals, as well as to improved treatment and prognosis. The results also underline the importance of stratifying and analyzing samples by age, especially in ASD and potentially other developmental disorders.
authors.affiliation: Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QT, UK. sb209@cam.ac.uk.
authors.forename: Jordan M
authors.initials: JM
authors.lastname: Ramsey
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
authors.forename: Jantine Ac
authors.initials: JA
authors.lastname: Broek
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Glennon
authors.forename: Nanda
authors.initials: N
authors.lastname: Rommelse
authors.forename: Barbara
authors.initials: B
authors.lastname: Franke
authors.forename: Hassan
authors.initials: H
authors.lastname: Rahmoune
authors.forename: Jan K
authors.initials: JK
authors.lastname: Buitelaar
authors.forename: Sabine
authors.initials: S
authors.lastname: Bahn
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