title: The association of hydrogel and biphasic calcium phosphate in the treatment of dehiscence-type peri-implant defects: an experimental study in dogs.
abstract: Hydrogel polymers have many applications in regenerative medicine. The aim of this study in dogs was to investigate bone regeneration in dehiscence-type peri-implant defects created surgically and treated with (i) biphasic calcium phosphate (BCP) granules alone; (ii) a composite putty hydroxypropyl methylcellulose (HPMC)/BCP (MBCP/putty); and (iii) a polymer crosslinked membrane of silanized-HPMC (Si-HPMC/BCP) compared with empty controls. At 3 months, new bone formation was significantly more important in defects filled with HPMC/BCP or Si-HPMC/BCP compared with spontaneous healing in control (P = 0.032 and P = 0.046 respectively) and more substantial compared with BCP alone. Furthermore, new bone formation in direct contact with the implant surface was observed in all three groups treated with BCP. The addition of HPMC to the BCP granules may have enhanced the initial stability of the material within the blood clot in these large and complex osseous defects. The Si-HPMC hydrogel may also act as an occlusive membrane covering the BCP, which could improve the stability of the granules in the defect area. However, the crosslinking time of the Si-HPMC is too long for easy handling and the mechanical properties remain to be improved. The composite MBCP/putty appears to be a valuable bone-graft material in complex defects in periodontology and implantology. These encouraging results should now be confirmed in clinical studies.
authors.affiliation: Laboratory of Osteo-Articular and Dental Tissue Engineering (LIOAD), INSERM, U791, 1 Place Alexis Ricordeau, 44042, Nantes, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Struillou
authors.forename: Mia
authors.initials: M
authors.lastname: Rakic
authors.forename: Zahi
authors.initials: Z
authors.lastname: Badran
authors.forename: Laure
authors.initials: L
authors.lastname: Macquigneau
authors.forename: Caroline
authors.initials: C
authors.lastname: Colombeix
authors.forename: Paul
authors.initials: P
authors.lastname: Pilet
authors.forename: Christian
authors.initials: C
authors.lastname: Verner
authors.forename: Olivier
authors.initials: O
authors.lastname: Gauthier
authors.forename: Pierre
authors.initials: P
authors.lastname: Weiss
authors.forename: Assem
authors.initials: A
authors.lastname: Soueidan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004285:Dogs; D020100:Hydrogels / Q000737:chemistry*; D006882:Hydroxyapatites / Q000737:chemistry*; D065347:Hypromellose Derivatives; D008567:Membranes, Artificial; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D016348:Osseointegration; D011108:Polymers / Q000737:chemistry; D019736:Prostheses and Implants; D013314:Stress, Mechanical; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D003432:Cross-Linking Reagents; D020100:Hydrogels; D006882:Hydroxyapatites; D008567:Membranes, Artificial; D011108:Polymers; C074950:hydroxyapatite-beta tricalcium phosphate; D065347:Hypromellose Derivatives; D008747:Methylcellulose; C020243:calcium phosphate
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