title: p63, Sharp1, and HIFs: master regulators of metastasis in triple-negative breast cancer.
abstract: Metastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior.
authors.affiliation: Department of Molecular Medicine, School of Medicine, University of Padua, Padua, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Piccolo
authors.forename: Elena
authors.initials: E
authors.lastname: Enzo
authors.forename: Marco
authors.initials: M
authors.lastname: Montagner
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009362:Neoplasm Metastasis; D064726:Triple Negative Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051793:Hypoxia-Inducible Factor 1; D008565:Membrane Proteins; C422085:BHLHE41 protein, human; C081876:CKAP4 protein, human