title: Organocatalytic oxa/aza-Michael-Michael cascade strategy for the construction of spiro [chroman/tetrahydroquinoline-3,3'-oxindole] scaffolds.
abstract: A new useful and effective chiral amine-catalyzed oxa- and aza-Michael-Michael cascade methodology for the construction of enantiomerically enriched indolinones spiro-fused with chromans or tetrahydroquinolines is reported. By employing suitable organocatalysts depending on the different Michael donors (Ar-OH/Ar-NHR), the processes offered excellent stereocontrol (dr >20:1, >99% ee) under mild conditions.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, China.
authors.forename: Haibin
authors.initials: H
authors.lastname: Mao
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin
authors.forename: Yang
authors.initials: Y
authors.lastname: Tang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Hongwen
authors.initials: H
authors.lastname: Hu
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu
mesh_terms: D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002839:Chromans; D007211:Indoles; D000078183:Oxindoles; D011804:Quinolines; D013141:Spiro Compounds; C585704:tetrahydroquinoline-3,3'-oxindole