title: Validation of the Polish version of the EORTC QLQ-BM22 module for the assessment of health-related quality of life in patients with bone metastases.
abstract: OBJECTIVE
  The aim of our study was to undertake a prospective validation study of the Polish version of the European Organization for Research and Treatment of Cancer (EORTC) bone metastases (QLQ-BM22) module used alongside the EORTC core measure.
  
  
  METHODS
  The translated module was pilot-tested according to the established EORTC guidelines. Patients with histological confirmation of malignancy and bone metastases, diagnosed by imaging studies, were eligible for the study. All patients filled out the Polish version of the QLQ-BM22 module in addition to QLQ-C30 and a demographic questionnaire. Standard validity and reliability analyses were performed.
  
  
  RESULTS
  One hundred and fifty-five patients were enrolled into the study, including 94 women (60.7 %) and 61 men (mean age ± SD; 59.1 ± 12.1). Cronbach's alpha coefficients, range 0.68-0.93, showed positive internal consistency. Re-test was undertaken with fifty patients (32.3 %). Interclass correlations for the EORTC QLQ-BM22 ranged from 0.91 to 0.93 and proved sufficient test-retest reliability. Satisfactory convergent and discriminant validity in multi-trait scaling analyses was seen.
  
  
  CONCLUSIONS
  Our study provides new and robust evidence which shows that the Polish version of the QLQ-BM22 module is a valid and reliable instrument for measuring health-related quality of life in patients with bone metastases. It is suitable for use in clinical trials and in research.
authors.affiliation: Department of Clinical Oncology, University Hospital in Krakow, Krakow, Poland.
authors.forename: Mirosława
authors.initials: M
authors.lastname: Püsküllüoğlu
authors.forename: Krzysztof A
authors.initials: KA
authors.lastname: Tomaszewski
authors.forename: Andrew
authors.initials: A
authors.lastname: Bottomley
authors.forename: Lori
authors.initials: L
authors.lastname: Holden
authors.forename: Iwona M
authors.initials: IM
authors.lastname: Tomaszewska
authors.forename: Roman
authors.initials: R
authors.lastname: Głowacki
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Bereza
authors.forename: Edward B
authors.initials: EB
authors.lastname: Golec
authors.forename: Edward
authors.initials: E
authors.lastname: Chow
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Krzemieniecki
mesh_terms: D001859:Bone Neoplasms / Q000523:psychology* / Q000556:secondary*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D011446:Prospective Studies; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014177:Translations
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