title: Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors.
abstract: A series of O-aryl- and alkyl-substituted phosphorodithioates were designed and synthesized as hydrogen sulfide (H2S) donors. H2S releasing capability of these compounds was evaluated using fluorescence methods. O-aryl substituted donors showed slow and sustained H2S release while O-alkylated compounds showed very weak H2S releasing capability. We also evaluated donors' protective effects against hydrogen peroxide (H2O2)-induced oxidative damage in myocytes and donors' toxicity toward B16BL6 mouse melanoma cells.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA 99164, USA. mxian@wsu.edu.
authors.forename: Chung-Min
authors.initials: CM
authors.lastname: Park
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhu
authors.forename: Armando
authors.initials: A
authors.lastname: Pacheco
authors.forename: Bo
authors.initials: B
authors.lastname: Peng
authors.forename: Nelmi O
authors.initials: NO
authors.lastname: Devarie-Baez
authors.forename: Powell
authors.initials: P
authors.lastname: Bagdon
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry*; D008546:Melanoma, Experimental; D051379:Mice; D015394:Molecular Structure; D032342:Muscle Cells / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress; D010710:Phosphates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D010710:Phosphates; C083120:phosphorodithioic acid; D006862:Hydrogen Sulfide
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