title: RACK1 to the future--a historical perspective.
abstract: This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1's role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.
authors.affiliation: Department of Life Sciences, Materials and Surface Science Institute and Stokes Institute, University of Limerick, Limerick, Ireland. Patrick.Kiely@ul.ie.
authors.forename: Dorit
authors.initials: D
authors.lastname: Ron
authors.forename: David R
authors.initials: DR
authors.lastname: Adams
authors.forename: George S
authors.initials: GS
authors.lastname: Baillie
authors.forename: Aideen
authors.initials: A
authors.lastname: Long
authors.forename: Rosemary
authors.initials: R
authors.lastname: O'Connor
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Kiely
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000378:metabolism; D057890:Epigenomics; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D014176:Protein Biosynthesis; D000075370:Receptors for Activated C Kinase; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D003598:Cytoskeletal Proteins; D009363:Neoplasm Proteins; C419368:RACK1 protein, human; D000075370:Receptors for Activated C Kinase; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins
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