title: MYC, metabolism, cell growth, and tumorigenesis.
abstract: The MYC proto-oncogene is frequently activated in human cancers through a variety of mechanisms. Its deregulated expression, unconstrained by inactivation of key checkpoints, such as p53, contributes to tumorigenesis. Unlike its normal counterpart, which is restrained by negative regulators, the unleashed MYC oncogene produces a transcription factor that alters global gene expression through transcriptional regulation, resulting in tumorigenesis. Key genes involved in ribosomal and mitochondrial biogenesis, glucose and glutamine metabolism, lipid synthesis, and cell-cycle progression are robustly activated by MYC, contributing to the acquisition of bioenergetics substrates for the cancer cell to grow and proliferate.
authors.affiliation: Abramson Cancer Center, Abramson Family Cancer Research Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19072, USA. dangvchi@exchange.upenn.edu
authors.forename: Chi V
authors.initials: CV
authors.lastname: Dang
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics; D005947:Glucose / Q000235:genetics; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008928:Mitochondria / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors; D005973:Glutamine; D005947:Glucose
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