title: Effects of Gosha-jinki-gan (Chinese herbal medicine: Niu-Che-Sen-Qi-Wan) on hyperinsulinemia and hypertriglyceridemia in prediabetic Zucker fatty rats.
abstract: The Chinese herbal medicine, Goshajinki-gan (GJ) (Niu-Che-Sen-Qi-Wan), has been widely used for treating patients with melalgia, lower back pain, numbness, and diabetic neuropathy. We investigated the effects of GJ on the regulation of serum insulin and triglyceride levels in obese Zucker fatty rats (fa/fa; ZFR). We administrated GJ to 6-week-old ZFR and non-obese lean rats (LR) for 12 weeks. Body weight and serum glucose, insulin, total cholesterol, and triglyceride levels were significantly increased at 18 weeks in ZFR as compared to the LR. GJ treatment in ZFR significantly suppressed elevation in serum glucose, insulin, and triglyceride levels, but no significant differences were observed in body weight and serum cholesterol levels in the ZFR group with GJ treatment compared to the ZFR group without GJ treatment. These results suggest that GJ may improve hyperinsulinemia and hypertriglyceridemia in ZFR and that GJ may be useful for preventing or delaying the onset of diabetes mellitus in a pre-diabetic state.
authors.affiliation: Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohatani University, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hirotani
authors.forename: K
authors.initials: K
authors.lastname: Okumura
authors.forename: U
authors.initials: U
authors.lastname: Yoko
authors.forename: M
authors.initials: M
authors.lastname: Myotoku
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D003920:Diabetes Mellitus / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006946:Hyperinsulinism / Q000188:drug therapy*; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D008297:Male; D008517:Phytotherapy; D051381:Rats; D011924:Rats, Zucker; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007328:Insulin; D014280:Triglycerides; C119642:gosha-jinki-gan