title: [Protective effect of shenfu injection pretreatment on brain of patients receiving aortic valve replacement undergoing cardiopulmonary bypass].
abstract: OBJECTIVE
  To observe the protective effect of Shenfu Injection (SFI) pretreatment on brain of patients receiving aortic valve replacement (AVR) undergoing cardiopulmonary bypass (CPB).
  
  
  METHODS
  Thirty AVR patients undergoing CPB were randomly assigned to 2 groups, the control group and the experimental group, 15 cases in each group. SFI at 1.5 mL/kg (dissolved in 250 mL 5% glucose solution) was intravenously dripped to those in the experimental group 5 days before operation, once daily for 5 successive days. SFI at 1.5 mL/kg (dissolved in 250 mL 5% glucose solution) was intravenously dripped to those 30 min before anesthesia induction. Equal dose of normal saline was intravenously dripped to those in the control group, and the other procedures were the same as those for patients in the experimental group. The venous blood sample (2 mL) was drawn from the right internal carotid vein immediately after induction of anesthesia (T1),10 min after CPB (T2), 30 min after GPB (T3), 2 h after CPB (T4), 24 h after CPB (T5), and 48 h after CPB (T6), thus detecting the plasma levels of S100beta and neuron specific enolase (NSE). And patients' cognitive function was assessed with mini-mental state examination (MMSE) scale on the day before operation, the 2nd and the 7th day after operation.
  
  
  RESULTS
  There was no statistical difference in the levels of S1001 and NSE between the two groups at T1 (P > 0.05). There was statistical difference in the levels of S100beta and NSE between the two groups at T2, T3, T4, T5, T6, when compared with those at T1 (P <0.05). Besides, the levels of S100beta and NSE at T2, T3, T4, T5, T6 were lower in the experimental group than in the control group, showing statistical difference (P <0.05). The MMSE scores decreased on the 2nd day after operation in the two groups, showing statistical difference when compared with those on the day before operation (P <0.05). It was lowered more obviously in the control group. There was no statistical difference in the MMSE score between the 7th day post-operation and the day before operation (P >0.05).
  
  
  CONCLUSIONS
  SFI pretreatment had protective effect on brain in AVR patients undergoing CPB.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, Medical College of Shihezi University, Xinjiang 832000, China. dengchao0993@sina.com
authors.forename: Chao
authors.initials: C
authors.lastname: Deng
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Dai
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Chen
authors.forename: Xi-wei
authors.initials: XW
authors.lastname: Dong
mesh_terms: D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D003071:Cognition / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007432:Intraoperative Period; D019194:Ischemic Preconditioning / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D064568:S100 Calcium Binding Protein beta Subunit / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; C492793:Shen-Fu; D010751:Phosphopyruvate Hydratase