title: Pretransplant Epstein-Barr virus serostatus and incidence of posttransplant lymphoproliferative disorder in pediatric renal transplants.
abstract: OBJECTIVE
  Pediatric renal transplant recipients are at increased risk of Epstein-Barr virus infection which may be due to the high percentage of Epstein-Barr virus seronegative recipients at the time of transplant in the pediatric age group. We aimed to assess the Epstein-Barr virus serostatus of recipients and donors and the incidence of posttransplant lymphoproliferative disorder in pediatric renal transplant at the Labafinejad Hospital in Tehran, Iran.
  
  
  METHODS
  We reviewed the clinical records of 183 children who had a renal transplant at the Labafinejad Hospital in Tehran, Iran, between 2003 and 2011.
  
  
  RESULTS
  Of all the patients, 61.2% were Epstein-Barr virus seropositive at the time of transplant. Graft survival rate and the rate of acute rejection episodes were not statistically different between the seropositive and seronegative recipients. Three patients (0.005%) had posttransplant lymphoproliferative disorder after transplant.
  
  
  CONCLUSIONS
  We showed that the rate of seronegative recipients in our cohort is similar to other studies, but the rate of posttransplant lymphoproliferative disorder was low in our recipients.
authors.affiliation: Transplantation Dialysis Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Rahimzadeh
authors.forename: Hasan
authors.initials: H
authors.lastname: Otukesh
authors.forename: Rozita
authors.initials: R
authors.lastname: Hoseini
authors.forename: Azam
authors.initials: A
authors.lastname: Riahifard
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016009:Chi-Square Distribution; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome