title: Adult T-cell leukemia/lymphoma triggered by adalimumab.
abstract: Here, we describe a 48-year-old woman infected by the human T-cell lymphotropic virus type 1 (HTLV-1) with spondyloarthritis, uveitis, bilateral episcleritis and neurogenic bladder. She had a history of a probable infective dermatitis associated with HTLV-1 (IDH) in childhood. After the use of adalimumab, she developed lymphocytosis and a cutaneous lymphoma associated with IDH. She had the diagnoses of IDH and of chronic adult T-cell leukemia/lymphoma, supported by the demonstration of proviral integration in the cutaneous lesion.
authors.affiliation: Laboratory of Pathology. Complexo Hospitalar Universitário Prof. Edgard Santos, Federal University of Bahia, Rua Dr. Augusto Viana, s/n, Canela, CEP:40.110-060, Salvador, Bahia, Brazil.
authors.forename: Achilea L
authors.initials: AL
authors.lastname: Bittencourt
authors.forename: Pedro D
authors.initials: PD
authors.lastname: Oliveira
authors.forename: Valeria G
authors.initials: VG
authors.lastname: Bittencourt
authors.forename: Edgar M
authors.initials: EM
authors.lastname: Carvalho
authors.forename: Lourdes
authors.initials: L
authors.lastname: Farre
mesh_terms: D000068879:Adalimumab; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000009:adverse effects*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000139:chemically induced*; D008875:Middle Aged
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007155:Immunologic Factors; D000068879:Adalimumab
keywords: Adalimumab; Adult T-cell leukemia/lymphoma; Anti-TNF-α drugs; Infective dermatitis associated with HTLV-1