title: Palladium-catalyzed direct intermolecular α-arylation of amides with aryl chlorides.
abstract: An efficient catalytic system for the direct intermolecular α-arylation of acetamide derivatives with aryl chlorides is presented. Chemoselectivities up to 10:1 in the mono- and diarylation of acetamides were achieved by careful selection of bases, solvents, and stoichiometry. Bis-arylated amides were prepared in up to 95% yield.
authors.affiliation: Department of Applied Chemistry, China Agricultural University, Beijing 100193, P. R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zheng
authors.forename: Tiezheng
authors.initials: T
authors.lastname: Jia
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Walsh
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; D000577:Amides; D002712:Chlorides; D010165:Palladium