title: The OGG1 Ser326Cys polymorphism and the risk of esophageal cancer: a meta-analysis.
abstract: BACKGROUND
  The oxoguanine DNA glycosylase (OGG1) Ser326Cys polymorphism has been implicated in susceptibility to esophageal cancer. Several studies investigated the association of this polymorphism with esophageal cancer in different populations. However, the results were contradictory. A meta-analysis was conducted to assess the association between the OGG1 Ser326Cys polymorphism and esophageal cancer susceptibility.
  
  
  METHODS
  Databases, including PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. A random-effects model was used.
  
  
  RESULTS
  Twelve studies involving 2363 cases and 3621 controls were included. Overall, a significant association between the OGG1 Ser326Cys polymorphism and esophageal cancer was observed for Cys/Cys versus Cys/Ser+Ser/Ser (OR=1.40; 95% CI 1.12-1.74; p=0.003; Pheterogeneity=0.18). In the subgroup analysis by ethnicity, a significant association was found among Asians (OR=1.51; 95% CI 1.15-1.96; p=0.002; Pheterogeneity=0.22), but not among Caucasians (OR=1.21; 95% CI 0.81-1.81; p=0.35; Pheterogeneity=0.21). In the subgroup analysis by pathologic type, we found that the Cys/Cys genotype was associated with increased esophageal squamous cell carcinoma risk (OR=1.86; 95% CI 1.36-2.53; p<0.0001; Pheterogeneity=0.73).
  
  
  CONCLUSIONS
  This meta-analysis suggested that the OGG1 Ser326Cys polymorphism was a risk factor of esophageal cancer.
authors.affiliation: 1 Department of Oncology, Shanghai Changzheng Hospital, Second Military Medical University , Shanghai, China .
authors.forename: Zhan
authors.initials: Z
authors.lastname: Wang
authors.forename: Lu
authors.initials: L
authors.lastname: Gan
authors.forename: Wei
authors.initials: W
authors.lastname: Nie
authors.forename: Yan
authors.initials: Y
authors.lastname: Geng
mesh_terms: D019943:Amino Acid Substitution; D045647:DNA Glycosylases / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008957:Models, Genetic; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D039781:PubMed; D012307:Risk Factors
chemical_list: D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human