title: PUA/PSS multilayer coated CaCO3 microparticles as smart drug delivery vehicles.
abstract: Hybrid CaCO3 microparticles coated by sodium poly(styrene sulfonate) (PSS) and aliphatic poly(urethane-amine) (PUA) were developed as thermal-/pH-responsive drug delivery vehicles via LbL self-assembly technique. The DOX release from the CaCO3 microparticles was higher than 60% within 36 h, whereas the value of PUA/PSS-coated microparticles was only 20%. The results demonstrated that the PUA/PSS multilayer coating could reduce the drug release rate and significantly assuage the initial burst release of DOX. In addition, the drug release of the hybrid microparticles was found to be thermal-/pH-dual responsive. More interestingly, more than 90% of DOX was released in 36 h at pH2.1 and 55 °C owing to the combined action of the dissolution of the CaCO3 core and the shrinkage of aliphatic PUA.
authors.affiliation: School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Du
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.forename: Jin
authors.initials: J
authors.lastname: Shi
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Shaokui
authors.initials: S
authors.lastname: Cao
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004317:Doxorubicin; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011137:Polystyrenes / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013696:Temperature
chemical_list: D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011137:Polystyrenes; D011140:Polyurethanes; C003321:polystyrene sulfonic acid; D004317:Doxorubicin; D002119:Calcium Carbonate
keywords: CaCO(3) microparticles; Drug delivery; Layer-by-layer; Polyelectrolyte; Thermal-/pH-responsive