title: Type 1 diabetes.
abstract: Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge of lifelong insulin administration. Agents that show promise for averting debilitating disease-associated complications have also been identified. However, despite broad organisational, intellectual, and fiscal investments, no means for preventing or curing type 1 diabetes exists, and, globally, the quality of diabetes management remains uneven. This Seminar discusses current progress in epidemiology, pathology, diagnosis, and treatment of type 1 diabetes, and prospects for an improved future for individuals with this disease.
authors.affiliation: Department of Pathology and Department of Pediatrics, University of Florida, Gainesville, FL, USA. Electronic address: atkinson@ufl.edu.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Atkinson
authors.affiliation: Barbara Davis Center for Childhood Diabetes, Aurora, CO, USA.
authors.forename: George S
authors.initials: GS
authors.lastname: Eisenbarth
authors.affiliation: Barbara Davis Center for Childhood Diabetes, Aurora, CO, USA.
authors.forename: Aaron W
authors.initials: AW
authors.lastname: Michels
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000473:pathology; D019397:Pancreas, Artificial
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
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