title: Osteonecrosis of the jaw - prevention and treatment strategies for oral health professionals.
abstract: Patients diagnosed with multiple myeloma and metastatic breast, prostate and renal cancers have a better opportunity for longer survival due to a myriad of chemotherapies regimens that attempt to manage disease progression while decreasing treatment-related side effects. Osteonecrosis of the jaws (ONJ) is a known side effect of bisphosphonates and other anti-neoplastic drugs. This complication can lead to oncologic treatment interruptions as well as diminished quality of life. Most recommendations for treatment of ONJ are based on position papers and case reports, while evidence-based treatment paradigms are lacking. With cancer survivorship on the rise, long-term chemotherapeutic side effects are becoming more prevalent and attention to untoward oral complications cannot be understated. In this review, the accepted recommendations for dental clearance prior to head and neck chemo-radiation therapy are put forth as a means of possibly preventing and treating drug induced ONJ.
authors.affiliation: Department of Dentistry & Maxillofacial Prosthetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Nicole V
authors.initials: NV
authors.lastname: Hinchy
authors.affiliation: Department of Dentistry & Maxillofacial Prosthetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Vijayvel
authors.initials: V
authors.lastname: Jayaprakash
authors.affiliation: Department of Dentistry & Maxillofacial Prosthetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Rachael A
authors.initials: RA
authors.lastname: Rossitto
authors.affiliation: Department of Oral Diagnostic Sciences, School of Dental Medicine, State University of New York at Buffalo, NY, USA.
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Anders
authors.affiliation: Department of Dentistry & Maxillofacial Prosthetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Kathryn C
authors.initials: KC
authors.lastname: Korff
authors.affiliation: Department of Dentistry & Maxillofacial Prosthetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Canallatos
authors.affiliation: Department of Dentistry & Maxillofacial Prosthetics, Roswell Park Cancer Institute, Buffalo, NY, USA. Electronic address: Maureen.Sullivan@RoswellPark.org.
authors.forename: Maureen A
authors.initials: MA
authors.lastname: Sullivan
mesh_terms: D003752:Dental Health Services; D006801:Humans; D007571:Jaw Diseases / Q000188:drug therapy / Q000517:prevention & control*; D010020:Osteonecrosis / Q000188:drug therapy / Q000517:prevention & control*; D012307:Risk Factors; D000078329:Workforce
keywords: Aging population; Antiangiogenics; Antiresorptives; Bisphosphonates; Cancer survivorship; Dental clearance; ONJ; Osteonecrosis; Osteoporosis; osteonecrosis of the jaws