title: [Macular choroidal thickness assessment with SD-OCT in high myopia with or without choroidal neovascularization].
abstract: OBJECTIVE
  To measure macular choroidal thickness (CT) using spectral-domain optical coherence tomography (SD-OCT) in eyes with myopic macular choroidal neovascularization (CNV), and to compare choroidal thickness in these eyes with highly myopic eyes without CNV.
  
  
  METHODS
  Sixty-four eyes with myopic CNV matched with 64 highly myopic eyes without CNV by age and axial length (AL) were examined between January 2010 and November 2011. OCT scans were performed with spectral-domain OCT (TOPCON OCT 2000). The reference position was changed from the vitreous to the choroid. OCT scan patterns consisted of seven sections; the subfoveal CT was measured manually between Bruch's membrane and the internal portion of the sclera in eyes with CNV and from the pigment epithelium to the scleral interface in eyes without CNV.
  
  
  RESULTS
  In the subgroup with CNV, the mean subfoveal CT was 51.71 μm ± 17.35. A statistically significant negative correlation was found between CT and AL (r=-0.615, P=0.0001). Regression analysis demonstrated a decrease of 8.4 μm per mm of AL. In the subgroup without CNV, matched with the CNV subgroup by age (P=0.597), and AL (P=0.813), the mean subfoveal CT was 93.35 μm ± 34.81 μm. The difference between the two subgroups was statistically significant (P<10(-4)).
  
  
  CONCLUSIONS
  Macular choroidal thickness is reduced in high myopia, especially when complicated by CNV. It has not yet been shown that choroidal thinning may be a risk factor for choroidal neovascularization, but our results may suggest that macular choroidal thinning may lead to hypoxic retinal changes resulting in secretion of VEGF and thus CNV.
  
  
  CONCLUSIONS
  Macular choroidal thinning observed in high myopia with CNV. These findings may suggest that choroidal changes may play a role in the pathogenesis of choroidal neovascularization.
authors.affiliation: Service d'ophtalmologie B, institut Hédi Rais, boulevard 9-Avril, 1006 Tunis, Tunisie. Electronic address: leila.elmatri@rns.tn.
authors.forename: L
authors.initials: L
authors.lastname: El Matri
authors.forename: M
authors.initials: M
authors.lastname: Bouladi
authors.forename: A
authors.initials: A
authors.lastname: Chebil
authors.forename: F
authors.initials: F
authors.lastname: Kort
authors.forename: L
authors.initials: L
authors.lastname: Largueche
authors.forename: F
authors.initials: F
authors.lastname: Mghaieth
mesh_terms: D000328:Adult; D002829:Choroid / Q000473:pathology*; D020256:Choroidal Neovascularization / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D009929:Organ Size; D012160:Retina / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: Choroid; Choroidal neovascularization; Choroïde; High myopia; Myopie forte; Néovaisseaux choroïdiens; SD-OCT