title: The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality.
abstract: Uric acid is the end product of purine metabolism in humans. High levels are causative in gout and urolithiasis. Hyperuricaemia has also been implicated in the pathophysiology of hypertension, chronic kidney disease (CKD), congestive heart failure (CHF), the metabolic syndrome, type 2 diabetes mellitus (T2DM), and atherosclerosis, with or without cardiovascular events. This article briefly reviews uric acid metabolism and summarizes the current literature on hyperuricaemia in cardiovascular disease and related co-morbidities, and emerging treatment options.
authors.affiliation: Bioscience, CVMD iMED, AstraZeneca R&D Mölndal, Mölndal, Sweden. david.gustafsson@astrazeneca.com
authors.forename: David
authors.initials: D
authors.lastname: Gustafsson
authors.forename: Robert
authors.initials: R
authors.lastname: Unwin
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology*; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology*; D009017:Morbidity
references.citation: BMJ. 2012 Jan 12;344:d8190
references.pmid: 22240117
references.citation: Hypertension. 2011 Jul;58(1):2-7
references.pmid: 21632472
references.citation: PLoS Genet. 2009 Jun;5(6):e1000504
references.pmid: 19503597
references.citation: J Heart Lung Transplant. 2011 Apr;30(4):408-13
references.pmid: 21145258
references.citation: QJM. 2011 Dec;104(12):1015-24
references.pmid: 21908382
references.citation: Blood Press. 2011 Jun;20(3):182-7
references.pmid: 21133824
references.citation: Circulation. 2006 Dec 5;114(23):2508-16
references.pmid: 17130343
references.citation: BMJ Open. 2012 Feb 15;2(1):e000282
references.pmid: 22337813
references.citation: Arthritis Care Res (Hoboken). 2011 Jan;63(1):102-10
references.pmid: 20824805
references.citation: Obesity (Silver Spring). 2013 Jan;21(1):E71-7
references.pmid: 23401248
references.citation: Iran J Kidney Dis. 2010 Apr;4(2):128-32
references.pmid: 20404423
references.citation: Arthritis Rheum. 2009 Jul 15;61(7):885-92
references.pmid: 19565556
references.citation: Am J Kidney Dis. 2006 Jan;47(1):51-9
references.pmid: 16377385
references.citation: Nephrol Dial Transplant. 2013 Sep;28(9):2221-8
references.pmid: 23543594
references.citation: Hypertension. 2003 Oct;42(4):474-80
references.pmid: 12953019
references.citation: JAMA. 1991 Dec 4;266(21):3008-11
references.pmid: 1820474
references.citation: Am J Physiol Renal Physiol. 2002 Jun;282(6):F991-7
references.pmid: 11997315
references.citation: Nephrol Dial Transplant. 2011 Jul;26(7):2175-81
references.pmid: 21148271
references.citation: N Engl J Med. 2008 Oct 23;359(17):1811-21
references.pmid: 18946066
references.citation: Clin J Am Soc Nephrol. 2013 Aug;8(8):1349-57
references.pmid: 23723338
references.citation: Semin Nephrol. 2005 Jan;25(1):39-42
references.pmid: 15660333
references.citation: Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):267-71
references.pmid: 16293798
references.citation: Hypertension. 2003 Sep;42(3):247-52
references.pmid: 12900431
references.citation: Clin J Am Soc Nephrol. 2010 Aug;5(8):1388-93
references.pmid: 20538833
references.citation: Int J Cardiol. 2011 Sep 1;151(2):143-7
references.pmid: 20542341
references.citation: Metabolism. 2006 Oct;55(10):1293-301
references.pmid: 16979398
references.citation: Arthritis Care Res (Hoboken). 2010 Feb;62(2):170-80
references.pmid: 20191515
references.citation: Cardiovasc Ther. 2012 Aug;30(4):217-26
references.pmid: 22099531
references.citation: Adv Chronic Kidney Dis. 2012 Nov;19(6):386-91
references.pmid: 23089273
references.citation: J Am Soc Nephrol. 2006 Jul;17(7):1791-5
references.pmid: 16775029
references.citation: Nat Rev Drug Discov. 2012 Jun 01;11(6):425-6
references.pmid: 22653201
references.citation: J Clin Invest. 2010 Jun;120(6):1791-9
references.pmid: 20516647
references.citation: Intern Med. 2009;48(6):415-20
references.pmid: 19293539
references.citation: Semin Arthritis Rheum. 2013 Jun;42(6):551-61
references.pmid: 23312548
references.citation: Am J Physiol Cell Physiol. 2007 Aug;293(2):C584-96
references.pmid: 17428837
references.citation: Eur Heart J. 2011 Mar;32(6):712-20
references.pmid: 21199831
references.citation: Hypertension. 2001 Nov;38(5):1101-6
references.pmid: 11711505
references.citation: Am J Physiol. 1995 Jan;268(1 Pt 1):E1-5
references.pmid: 7840165
references.citation: Cochrane Database Syst Rev. 2013 Jan 31;(1):CD008652
references.pmid: 23440832
references.citation: Curr Opin Rheumatol. 2013 Mar;25(2):210-6
references.pmid: 23370374
references.citation: Kidney Blood Press Res. 2012;35(3):153-60
references.pmid: 22116196
references.citation: Adv Chronic Kidney Dis. 2012 Nov;19(6):358-71
references.pmid: 23089270
references.citation: Diabetes Care. 2008 Feb;31(2):361-2
references.pmid: 17977935
references.citation: Arthritis Care Res (Hoboken). 2012 Oct;64(10):1431-46
references.pmid: 23024028
references.citation: Kidney Blood Press Res. 2012;35(6):477-82
references.pmid: 22688828
references.citation: Congest Heart Fail. 2011 Jan-Feb;17(1):25-30
references.pmid: 21272224
references.citation: Am J Hypertens. 1996 Aug;9(8):746-52
references.pmid: 8862220
references.citation: Diabetes Care. 2009 Sep;32(9):1737-42
references.pmid: 19549729
references.citation: J Am Soc Nephrol. 2010 Jan;21(1):64-72
references.pmid: 19926891
references.citation: Aliment Pharmacol Ther. 2011 Oct;34(7):757-66
references.pmid: 21790685
references.citation: Nephrol Dial Transplant. 2012 Feb;27(2):608-12
references.pmid: 21613382
references.citation: Ann Intern Med. 1999 Jul 6;131(1):7-13
references.pmid: 10391820
references.citation: J Am Soc Nephrol. 2002 Dec;13(12):2888-97
references.pmid: 12444207
references.citation: BMJ. 2008 Feb 9;336(7639):309-12
references.pmid: 18244959
references.citation: Circ Heart Fail. 2010 Jan;3(1):73-81
references.pmid: 19933411
references.citation: Nucleosides Nucleotides Nucleic Acids. 2011 Dec;30(12):1018-29
references.pmid: 22132951
references.citation: Ann Intern Med. 2005 Oct 4;143(7):499-516
references.pmid: 16204163
references.citation: Liver Int. 2012 Oct;32(9):1443-50
references.pmid: 22764879
references.citation: Lancet. 2010 Jun 19;375(9732):2161-7
references.pmid: 20542554
references.citation: Diabetologia. 2007 Dec;50(12):2572-9
references.pmid: 17928991
references.citation: JAMA. 2008 Aug 27;300(8):924-32
references.pmid: 18728266
references.citation: Arthritis Res Ther. 2010;12(2):R63
references.pmid: 20370912
references.citation: J Am Coll Cardiol. 2011 Aug 16;58(8):820-8
references.pmid: 21835317
references.citation: Diabetes Obes Metab. 2012 Apr;14(4):299-303
references.pmid: 21992452
references.citation: Circ Cardiovasc Genet. 2010 Dec;3(6):523-30
references.pmid: 20884846
references.citation: Hypertension. 2012 Nov;60(5):1148-56
references.pmid: 23006736
references.citation: Ann Rheum Dis. 2010 Oct;69(10):1738-43
references.pmid: 20858623
references.citation: J Card Fail. 2012 Sep;18(9):694-701
references.pmid: 22939038
references.citation: PLoS One. 2012;7(2):e30456
references.pmid: 22348008
references.citation: J Clin Pharmacol. 2013 Feb;53(2):211-6
references.pmid: 23436266
references.citation: Diabetes. 2011 Apr;60(4):1258-69
references.pmid: 21346177
references.citation: Annu Rev Med. 2013;64:325-37
references.pmid: 23327525
references.citation: J Biol Chem. 2008 Oct 3;283(40):26834-8
references.pmid: 18701466
references.citation: J Clin Hypertens (Greenwich). 2013 Jun;15(6):435-42
references.pmid: 23730993
references.citation: Congest Heart Fail. 2012 May-Jun;18(3):179-82
references.pmid: 22587748
references.citation: Am J Physiol Renal Physiol. 2009 Sep;297(3):F612-9
references.pmid: 19587147
references.citation: Drugs. 2011 Jul 30;71(11):1413-39
references.pmid: 21812506
references.citation: Nat Genet. 2013 Feb;45(2):145-54
references.pmid: 23263486