title: Green tea catechin induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2 (TRPM2).
abstract: The major polyphenols in green tea, (-)-epigallocatechin and (-)-epigallocatechin gallate, have been shown to enhance the phagocytic activity of macrophage-like cells; however, the mechanism involved was not clarified. In this study, we have identified that the catechins induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2.
authors.affiliation: NARO Institute of Vegetable and Tes Science, 2769 Kanaya-Shishidoi, Shimada, Shizuoka, 428-8501, Japan, monobe@affrc.go.jp.
authors.forename: Manami
authors.initials: M
authors.lastname: Monobe
authors.forename: Kaori
authors.initials: K
authors.lastname: Ema
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Tokuda
authors.forename: Mari
authors.initials: M
authors.lastname: Maeda-Yamamoto
references.citation: Nat Med. 2008 Jul;14(7):738-47
references.pmid: 18542050
references.citation: Biochem Biophys Res Commun. 2007 Dec 7;364(1):79-85
references.pmid: 17927962
references.citation: Free Radic Res. 2003 Aug;37(8):881-90
references.pmid: 14567448
references.citation: Nat Immunol. 2011 Nov 20;13(1):29-34
references.pmid: 22101731
references.citation: Toxicol In Vitro. 2004 Oct;18(5):555-61
references.pmid: 15251172
references.citation: Biol Pharm Bull. 2004 Mar;27(3):277-81
references.pmid: 14993788
references.citation: FEBS Lett. 2000 Sep 22;481(3):245-8
references.pmid: 11007972
references.citation: J Immunol. 2010 Mar 1;184(5):2386-93
references.pmid: 20107186
references.citation: J Clin Invest. 2000 Dec;106(12):1521-30
references.pmid: 11120759
references.citation: Blood. 2001 Oct 1;98(7):2152-9
references.pmid: 11568002
references.citation: Cytotechnology. 2010 Jul;62(3):201-3
references.pmid: 20502963
references.citation: J Agric Food Chem. 2007 Apr 4;55(7):2543-7
references.pmid: 17338546
references.citation: J Clin Invest. 2001 Jan;107(1):23-5
references.pmid: 11134174
references.citation: Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6745-50
references.pmid: 22493272
references.citation: J Nutr. 2002 Jul;132(7):1836-9
references.pmid: 12097656
references.citation: Biochem Pharmacol. 2003 Nov 1;66(9):1769-78
references.pmid: 14563487
references.citation: Nat Struct Mol Biol. 2004 Apr;11(4):380-1
references.pmid: 15024383