title: A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fat to modulate serum HDL-cholesterol concentrations.
abstract: There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common LPL polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40-69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genome-wide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (S447×) mutation (D' = 0.99) of LPL. We found that carrying the T allele reflecting the LPL ×447 allele was positively associated with follow-up measurement of HDL-C concentrations (P < 0.001). In the linear regression model adjusted for baseline HDL-C concentration and potential risk factors, we observed interactive effects of the polymorphism and consumption of alcohol (P-interaction < 0.01) and unsaturated fat (P-interaction < 0.05) on follow-up measurement of HDL-C concentrations. We also observed interactive effects of the polymorphism and body mass index (P-interaction < 0.01) on follow-up measurement of TG concentrations after adjusting for the baseline level and potential risk factors. Our findings suggest that carriers of the LPL ×447 allele benefit from moderate alcohol consumption and a diet high in unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the LPL ×447 allele need to control body weight to prevent hypertriglyceridemia.
authors.affiliation: Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, Seoul, Korea.
authors.forename: Inkyung
authors.initials: I
authors.lastname: Baik
authors.forename: Seungku
authors.initials: S
authors.lastname: Lee
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Chol
authors.initials: C
authors.lastname: Shin
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000483:Alleles; D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics*; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000209:etiology / Q000235:genetics; D015810:Linkage Disequilibrium; D008071:Lipoprotein Lipase / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009765:Obesity / Q000097:blood / Q000150:complications / Q000235:genetics; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D056910:Republic of Korea; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; D000431:Ethanol; D008071:Lipoprotein Lipase