title: [Research on the incompatibility of Radix adenophora, Radix glehniae combined with Veratrum nigrum L. by uniform designed toxicity assay].
abstract: OBJECTIVE
  To study the toxicity changes of different proportions of Radix Adenophora, Radix Glehniae combined with Veratrum nigrum L., thus providing acute toxicity data and investigating whether decoction factors were correlated with toxicity.
  
  
  METHODS
  The uniform design method was used by two factors and seven levels to investigate the toxicity changes in different proportions of Radix Adenophora, Radix Glehniae combined with Veratrum nigrum L. The decoction factors were also investigated.
  
  
  RESULTS
  The compatibility toxicity was affected mainly by Veratrum nigrum L. and the toxicity increased along with increased doses of Veratrum nigrum L. The toxicity of co-decoction was higher than mixed decoction in the same dosage of Radix Glehniae and Veratrum nigrum L. The promotion of the dissolution of the toxic component of Veratrum nigrum L. in co-decoction may be the cause of the higher toxicity.
  
  
  CONCLUSIONS
  Radix Adenophora and Radix Glehniae combined with Veratrum nigrum L. resulted in higher toxicity, which indicated that the incompatibility between Radix Adenophora, Radix Glehniae, and Veratrum nigrum L. In clinic practice, a prescription contained these drugs should be avoided.
authors.affiliation: School of Pharmacy, Central South University, Changsha 410013, China.
authors.forename: Guan-xiu
authors.initials: GX
authors.lastname: Zhu
authors.forename: Yu-Guang
authors.initials: YG
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Yang
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Lu
authors.forename: Zeng-Chun
authors.initials: ZC
authors.lastname: Ma
authors.forename: Qian-De
authors.initials: QD
authors.lastname: Liang
authors.forename: Cheng-Rong
authors.initials: CR
authors.lastname: Xiao
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Tan
authors.forename: Xiang-lin
authors.initials: XL
authors.lastname: Tang
authors.forename: Bo-li
authors.initials: BL
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000818:Animals; D004336:Drug Antagonism; D004344:Drug Incompatibility; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice
chemical_list: D004365:Drugs, Chinese Herbal