title: Association of AHSG gene polymorphisms with ischemic stroke in a Han Chinese population.
abstract: Previous studies have shown associations of fetuin-A (alpha2-Heremans-Schmid glycoprotein, AHSG) with various disorders, including insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and atherosclerosis. In this study, genotype and allele frequencies of the rs4918 SNP in the AHSG gene were examined in 380 patients with ischemic stroke and 350 healthy controls from a Northern Han Chinese population via the PCR-RFLP technique. Frequencies of the GG genotype and the G allele in AHSG (rs4918) were significantly higher in patients with ischemic stroke or atherosclerotic cerebral infarction than those in the control group (P < 0.05). Logistic regression analysis demonstrated the significance of rs4918 in these patients, after adjustment for confounding factors (P < 0.05). These findings suggest that rs4918 SNPs of the AHSG gene are associated with a risk for ischemic stroke in a Northern Han Chinese population.
authors.affiliation: Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, 110001, China, haojiemeitao@yahoo.com.cn.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Ma
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: He
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Liying
authors.initials: L
authors.lastname: Yuan
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Dai
authors.forename: Jing
authors.initials: J
authors.lastname: Qiu
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D020521:Stroke / Q000235:genetics*; D060749:alpha-2-HS-Glycoprotein / Q000235:genetics*
chemical_list: C556354:AHSG protein, human; D060749:alpha-2-HS-Glycoprotein