title: Response surface methodology applied to SPE for the determination of ibuprofen in various types of water samples.
abstract: Over the last few years, there has been a growing concern about the presence of pharmaceuticals in the environment. The main objective of this study was to develop and validate an SPE method using surface response methodology for the determination of ibuprofen in different types of water samples. The influence of sample pH and sample volume on the ibuprofen recovery was studied. The effect of each studied independent variable is pronounced on the dependent variable (ibuprofen recovery). Good selectivity, extraction efficiency, and precision were achieved using 600 mL of sample volume with the pH adjusted to 2.2. LC with fluorescence detection was employed. The optimized method was applied to 20 water samples from the North and South of Portugal.
authors.affiliation: REQUIMTE, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Porto, Portugal.
authors.forename: Paula
authors.initials: P
authors.lastname: Paíga
authors.forename: Cristina
authors.initials: C
authors.lastname: Delerue-Matos
mesh_terms: D002853:Chromatography, Liquid; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000032:analysis*; D045483:Rivers / Q000737:chemistry*; D052616:Solid Phase Extraction; D013499:Surface Properties; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D014874:Water Pollutants, Chemical; D007052:Ibuprofen
keywords: Ibuprofen; Response Surface Methodology; SPE; Water samples