title: Genetic variability of inflammatory genes in the Brazilian population.
abstract: Inflammatory gene variants have been associated with several diseases, including cancer, diabetes, vascular diseases, neurodegenerative diseases, arthritis, and others. Therefore, determining the population genetic composition of inflammation-related genes can be useful for the determination of general risk, prognostic and therapeutic strategies to prevent or cure specific diseases. We have aimed to identify polymorphism genotype frequencies in genes related to the inflammatory response in the Brazilian population, namely, IκBL -62AT, IκBL -262CT, tumor necrosis factors alpha (TNFa) -238GA, TNFa -308GA, lymphotoxin-alpha (LTa) +80AC, LTa +252AG, FAS -670AG, and FASL -844TC, considering the white, black, and Pardo ethnicities of the São Paulo State. Our results suggest that the Brazilian population is under a miscegenation process at the current time, since some genotypes are not in the Hardy-Weinberg equilibrium. In addition, we conclude that the Pardo ethnicity is derived from a complex mixture of ethnicities, including the native Indian population.
authors.affiliation: 1 Programa de Pós Graduação em Biotecnologia, Universidade Federal do Espírito Santo , Vitória, Espírito Santo, Brazil .
authors.forename: Marcelo
authors.initials: M
authors.lastname: dos Santos
authors.forename: Elaine
authors.initials: E
authors.lastname: Stur
authors.forename: Lucas Lima
authors.initials: LL
authors.lastname: Maia
authors.forename: Lidiane Pignaton
authors.initials: LP
authors.lastname: Agostini
authors.forename: Gabriela Tonini
authors.initials: GT
authors.lastname: Peterle
authors.forename: Suzanny Oliveira
authors.initials: SO
authors.lastname: Mendes
authors.forename: Eloiza Helena
authors.initials: EH
authors.lastname: Tajara
authors.forename: Marcos Brasilino
authors.initials: MB
authors.lastname: de Carvalho
authors.forename: Iúri Drumond
authors.initials: ID
authors.lastname: Louro
authors.forename: Adriana Madeira Álvares
authors.initials: AM
authors.lastname: Silva-Conforti
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D053222:Fas Ligand Protein / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D008233:Lymphotoxin-alpha / Q000235:genetics; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D000949:Histocompatibility Antigens Class II; D008233:Lymphotoxin-alpha; C120111:NFKBIL1 protein, human; D014409:Tumor Necrosis Factor-alpha
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