title: Association of biomarkers of inflammation, cartilage and bone turnover with gender, disease activity, radiological damage and sacroiliitis by magnetic resonance imaging in patients with early spondyloarthritis.
abstract: To assess the association between biomarkers of inflammation, cartilage and bone turnover with gender, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Spondylitis Disease Activity Score (ASDAS) and bone marrow oedema in resonance magnetic imaging (MRI) of sacroiliac joints (SIJs) and radiological damage in early spondyloarthritis (SpA). Cross-sectional study of 60 patients (56.7 % females; mean age, 32.4 years) with early SpA. Sociodemographic data, clinical features, serum matrix metalloproteinase 3 (MMP-3), high sensitivity C-reactive protein (hsCRP), C-terminal cross-linking telopeptides of type I collagen (CTX-I) and urinary deoxypyridinoline, ASDAS, BASDAI, BASFI, BASRI and MRI of the SIJs were collected. The mean (SD) disease duration was 12.4 (6.8 months). Twenty-two (68.7 %) of the 32 patients had active sacroiliitis by MRI. MMP-3 and CTX I correlated with swollen joint (r = 0.515, r = 0.386, p = 0.01). hsCRP correlated with ESR (r = 0.303, p = 0.05), with CRP (r = 0.455, p = 0.01) and with total BASRI (r = 0.95, p = 0.05). Biomarkers were unrelated with the rest of variables. Levels of MMP-3 (44.3 ± 52.4 vs 24.7 ± 33.4, p < 0.05) and CTX-I (0.53 ± 0.45 vs 0.24 ± 0.38; p < 0.05) were higher in men. Our study shows that CTX-I and MMP-3 are a marker of peripheral disease activity in early SpA. Male gender had higher levels of CTX-I and MMP-3, which may indicate higher disease activity. Higher hsCRP levels trended towards correlation with more baseline radiographic damage. Therefore, these biomarkers may help identify a subgroup of patients who will need closer monitoring and more intensive treatment.
authors.affiliation: Rheumatology Unit, Hospital Universitario Fundación Alcorcón, Avda. Budapest s/n, 28922, Alcorcón, Madrid, Spain, ralmodovar@fhalcorcon.es.
authors.forename: Raquel
authors.initials: R
authors.lastname: Almodóvar
authors.forename: Valeria
authors.initials: V
authors.lastname: Ríos
authors.forename: Sara
authors.initials: S
authors.lastname: Ocaña
authors.forename: Milena
authors.initials: M
authors.lastname: Gobbo
authors.forename: María-Luisa
authors.initials: ML
authors.lastname: Casas
authors.forename: Pedro
authors.initials: P
authors.lastname: Zarco-Montejo
authors.forename: Xavier
authors.initials: X
authors.lastname: Juanola
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000097:blood; D008875:Middle Aged; D010455:Peptides / Q000097:blood; D058566:Sacroiliitis / Q000097:blood* / Q000473:pathology; D012737:Sex Factors; D013167:Spondylitis, Ankylosing / Q000097:blood* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; C036020:deoxypyridinoline; D002097:C-Reactive Protein; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3
references.citation: Arthritis Rheum. 1998 Dec;41(12):2263-70
references.pmid: 9870884
references.citation: Rheumatology (Oxford). 1999 Jan;38(1):21-7
references.pmid: 10334678
references.citation: Eur J Med Res. 2000 Dec 29;5(12):507-11
references.pmid: 11147993
references.citation: Best Pract Res Clin Rheumatol. 2010 Oct;24(5):671-82
references.pmid: 21035087
references.citation: Arthritis Rheum. 2011 Dec;63(12):3789-800
references.pmid: 22127697
references.citation: J Rheumatol. 1994 Dec;21(12):2281-5
references.pmid: 7699629
references.citation: Ann Rheum Dis. 2011 Jan;70(1):25-31
references.pmid: 21109520
references.citation: Arthritis Rheum. 2007 Jun;56(6):1846-53
references.pmid: 17530713
references.citation: Rheumatology (Oxford). 1999 Sep;38(9):878-82
references.pmid: 10515650
references.citation: Arthritis Rheum. 2004 Sep;50(9):2942-53
references.pmid: 15457463
references.citation: Ann Rheum Dis. 2011 May;70(5):827-30
references.pmid: 21242234
references.citation: Reumatol Clin. 2010 Mar;6 Suppl 1:6-10
references.pmid: 21794746
references.citation: Br J Rheumatol. 1997 Jan;36(1):50-3
references.pmid: 9117174
references.citation: Ann Rheum Dis. 2009 Jan;68(1):18-24
references.pmid: 18625618
references.citation: J Rheumatol. 2011 Aug;38(8):1644-50
references.pmid: 21632677
references.citation: J Rheumatol. 2008 Oct;35(10):2030-7
references.pmid: 18785308
references.citation: Arthritis Rheum. 1991 Oct;34(10):1218-27
references.pmid: 1930310
references.citation: Arthritis Rheum. 2004 Oct 15;51(5):691-9
references.pmid: 15478146
references.citation: Ann Rheum Dis. 2009 Jun;68(6):777-83
references.pmid: 19297344
references.citation: Arthritis Res Ther. 2012 Apr 30;14(2):R98
references.pmid: 22546520
references.citation: Arthritis Res. 2002;4 Suppl 3:S39-49
references.pmid: 12110122
references.citation: Ann Rheum Dis. 2010 Jul;69(7):1338-41
references.pmid: 20498207
references.citation: Yonsei Med J. 2008 Apr 30;49(2):288-94
references.pmid: 18452267
references.citation: Ann Rheum Dis. 2009 Dec;68(12):1811-8
references.pmid: 19060001
references.citation: Ann Rheum Dis. 2011 Aug;70(8):1375-81
references.pmid: 21551511
references.citation: Ann Rheum Dis. 2009 Oct;68(10):1520-7
references.pmid: 19454404
references.citation: Curr Rheumatol Rep. 2010 Oct;12(5):318-24
references.pmid: 20714832
references.citation: Ann Rheum Dis. 2008 Apr;67(4):511-7
references.pmid: 17644552
references.citation: Rheumatology (Oxford). 2006 Apr;45(4):414-20
references.pmid: 16287916
references.citation: Arthritis Rheum. 2000 Apr;43(4):852-8
references.pmid: 10765930
references.citation: Ann Rheum Dis. 2002 Feb;61(2):161-6
references.pmid: 11796404