title: The endocannabinoid system and its role in the pathogenesis and treatment of cardiovascular disturbances in cirrhosis.
abstract: It has been known for over half a century that liver cirrhosis is associated with abnormal cardiovascular function. Although the mechanisms underlying the association of portal hypertension and hyperdynamic circulation have been intensively investigated during the past decades, the results are still inconclusive. This review focuses on the role that the endocannabinoids and their receptors could play in the pathogenesis of the cirrhotic cardiomyopathy, as well as on the treatment options that they offer.
authors.affiliation: Lucian Blaga" University,,,Victor Papilian" Faculty of Medicine, Sibiu, Romania. lorenamaries@yahoo.com
authors.forename: L
authors.initials: L
authors.lastname: Măries
authors.forename: I
authors.initials: I
authors.lastname: Manitiu
mesh_terms: D063387:Cannabinoid Receptor Antagonists / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D063388:Endocannabinoids / Q000502:physiology*; D006439:Hemodynamics; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D011379:Prognosis
chemical_list: D063387:Cannabinoid Receptor Antagonists; D063388:Endocannabinoids