title: Urticarial vasculitis: a retrospective study of 15 cases.
abstract: BACKGROUND
  Urticarial vasculitis is a subtype of vasculitis characterized clinically by urticarial lesions and histologically by necrotizing vasculitis.
  
  
  OBJECTIVE
  To study the clinical and histologic features of urticarial vasculitis in patients seen in the dermatology department of Hospital Universitario Virgen de Rocío in Seville, Spain, and to examine the association between hypocomplementemia and systemic disease.
  
  
  METHODS
  We performed a chart review of histologically confirmed cases of urticarial vasculitis in the database of our department covering a period of 10 years.
  
  
  RESULTS
  Fifteen patients (9 women and 6 men with a median age of 51 years) were included. In 14 patients (93%), the lesions persisted for more than 24hours, and in 9 cases (60%) the lesions resolved leaving residual purpura or hyperpigmentation. Seven patients (47%) had low complement levels in the blood, 12 (80%) had extracutaneous symptoms, and 8 (53%) had associated systemic disease, the most common of which was systemic lupus erythematosus.
  
  
  CONCLUSIONS
  Urticarial vasculitis may be underdiagnosed. Response to treatment is variable, and hypocomplementemia and extracutaneous symptoms may indicate the presence of associated systemic disease.
authors.affiliation: Servicio de Dermatología, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain. fatimacordoba@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: Moreno-Suárez
authors.forename: Á
authors.initials: Á
authors.lastname: Pulpillo-Ruiz
authors.forename: T
authors.initials: T
authors.lastname: Zulueta Dorado
authors.forename: J
authors.initials: J
authors.lastname: Conejo-Mir Sánchez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018771:Arthralgia / Q000150:complications; D002648:Child; D003165:Complement System Proteins / Q000172:deficiency; D003240:Connective Tissue Diseases / Q000150:complications; D005260:Female; D005334:Fever / Q000150:complications; D006633:Histamine Antagonists / Q000627:therapeutic use; D006785:Hospitals, University; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D063189:Symptom Assessment; D014581:Urticaria / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D006633:Histamine Antagonists; D007166:Immunosuppressive Agents; D003165:Complement System Proteins
keywords: Autoimmune disease; Enfermedad autoinmune; Hipocomplementemia; Hypocomplementemia; Urticaria vasculitis; Urticarial vasculitis