title: A comparison of two commercial volumetry software programs in the analysis of pulmonary ground-glass nodules: segmentation capability and measurement accuracy.
abstract: OBJECTIVE
  To compare the segmentation capability of the 2 currently available commercial volumetry software programs with specific segmentation algorithms for pulmonary ground-glass nodules (GGNs) and to assess their measurement accuracy.
  
  
  METHODS
  In this study, 55 patients with 66 GGNs underwent unenhanced low-dose CT. GGN segmentation was performed by using 2 volumetry software programs (LungCARE, Siemens Healthcare; LungVCAR, GE Healthcare). Successful nodule segmentation was assessed visually and morphologic features of GGNs were evaluated to determine factors affecting segmentation by both types of software. In addition, the measurement accuracy of the software programs was investigated by using an anthropomorphic chest phantom containing simulated GGNs.
  
  
  RESULTS
  The successful nodule segmentation rate was significantly higher in LungCARE (90.9%) than in LungVCAR (72.7%) (p = 0.012). Vascular attachment was a negatively influencing morphologic feature of nodule segmentation for both software programs. As for measurement accuracy, mean relative volume measurement errors in nodules ≥ 10 mm were 14.89% with LungCARE and 19.96% with LungVCAR. The mean relative attenuation measurement errors in nodules ≥ 10 mm were 3.03% with LungCARE and 5.12% with LungVCAR.
  
  
  CONCLUSIONS
  LungCARE shows significantly higher segmentation success rates than LungVCAR. Measurement accuracy of volume and attenuation of GGNs is acceptable in GGNs ≥ 10 mm by both software programs.
authors.affiliation: Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul 110-744, Korea.
authors.forename: Hyungjin
authors.initials: H
authors.lastname: Kim
authors.forename: Chang Min
authors.initials: CM
authors.lastname: Park
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Lee
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jin Mo
authors.initials: JM
authors.lastname: Goo
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012984:Software; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*
keywords: Lung neoplasms; Multidetector computed tomography; Phantoms, imaging; Solitary pulmonary nodule; Technology, radiologic
references.citation: Radiology. 2009 Apr;251(1):26-37
references.pmid: 19332844
references.citation: AJR Am J Roentgenol. 2002 May;178(5):1053-7
references.pmid: 11959700
references.citation: Radiology. 2007 Oct;245(1):267-75
references.pmid: 17885195
references.citation: Phys Med Biol. 2011 Jul 21;56(14):4557-77
references.pmid: 21725140
references.citation: AJR Am J Roentgenol. 2010 Feb;194(2):398-406
references.pmid: 20093602
references.citation: Eur Radiol. 2007 Aug;17(8):1979-84
references.pmid: 17206420
references.citation: Korean J Radiol. 2011 Mar-Apr;12(2):145-55
references.pmid: 21430930
references.citation: IEEE Trans Med Imaging. 2003 Oct;22(10):1259-74
references.pmid: 14552580
references.citation: Radiographics. 2007 Mar-Apr;27(2):391-408
references.pmid: 17374860
references.citation: J Comput Assist Tomogr. 2008 Sep-Oct;32(5):792-8
references.pmid: 18830114
references.citation: Radiology. 2009 Dec;253(3):606-22
references.pmid: 19952025
references.citation: World J Surg. 2007 Feb;31(2):314-7
references.pmid: 17219276
references.citation: Eur Radiol. 2009 Apr;19(4):800-8
references.pmid: 19018537
references.citation: Radiology. 2008 Aug;248(2):625-31
references.pmid: 18641255
references.citation: IEEE Trans Med Imaging. 2004 Jul;23(7):903-21
references.pmid: 15250643
references.citation: Eur Radiol. 2009 Mar;19(3):552-60
references.pmid: 18925404
references.citation: J Thorac Oncol. 2011 Feb;6(2):244-85
references.pmid: 21252716
references.citation: AJR Am J Roentgenol. 2007 Feb;188(2):306-12
references.pmid: 17242235
references.citation: AJR Am J Roentgenol. 2010 Dec;195(6):W408-14
references.pmid: 21098172
references.citation: Radiology. 2010 Apr;255(1):199-206
references.pmid: 20123896