title: Animal vaccines based on orally presented yeast recombinants.
abstract: In veterinary vaccinology, the oral route of administration is an attractive alternative compared to the commonly used parenteral route. Yeasts have a number of properties that make them potential live delivery systems for oral vaccination purposes such as their high expression levels, their GRAS status, adjuvant properties, and post-translational modification possibilities. Consequently, yeasts have been employed for the expression of heterologous genes and for the production of therapeutic proteins. Yeast-based vaccines are reviewed with regard to their ability to express and produce antigens from pathogens for veterinary use. Many of these vaccines have been shown to elicit protective immune responses following oral immunization in animals. Ultimately, yeast-based oral vaccines may offer a potential opportunity for the development of novel ideal vaccines in veterinary medicine.
authors.affiliation: Department of Infectious Diseases, College of Veterinary Medicine and Seoul National University, Seoul, Republic of Korea.
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Shin
authors.forename: Han Sang
authors.initials: HS
authors.lastname: Yoo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D016503:Drug Delivery Systems / Q000379:methods*; D015870:Gene Expression; D019936:Probiotics / Q000627:therapeutic use; D014611:Vaccination / Q000662:veterinary*; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology; D015003:Yeasts / Q000235:genetics*
chemical_list: D000941:Antigens; D014612:Vaccines
keywords: Live delivery system; Oral immunization; Veterinary vaccines; Yeast