title: Recruitment of transcription complexes to enhancers and the role of enhancer transcription.
abstract: Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Medicine, Genetics Institute, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610, USA.
authors.forename: Jared S
authors.initials: JS
authors.lastname: Stees
authors.forename: Fred
authors.initials: F
authors.lastname: Varn
authors.forename: Suming
authors.initials: S
authors.lastname: Huang
authors.forename: John
authors.initials: J
authors.lastname: Strouboulis
authors.forename: Jörg
authors.initials: J
authors.lastname: Bungert
keywords: RNA; enhancer; locus control region; looping; transcription; transcription factor
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