title: [Surveillance of schistosome antibodies in population in mountainous schistosomiasis endemic regions in China].
abstract: OBJECTIVE
  To understand the dynamics of schistosome antibodies in population in mountainous schistosomiasis low endemic regions, China, so as to provide the evaluation reference for immunodiagnosis.
  
  
  METHODS
  The people who consecutively received the indirect heamagglutination assay (IHA) for schistosomiasis and Kato-Katz technique were enrolled in this study in Guixiang Village, Danling County, Sichuan Province from 2006 to 2011. The positive rates for schistosome antibodies, antibody titers and eggs per gram (EPG) were analyzed.
  
  
  RESULTS
  A total of 353 people were investigated in this study from 2006 to 2011. The positive rates for schistosome antibodies decreased from 20.73% to 13.67%, and the geometric mean reciprocal titer (GMRT) decreased from 1.63 to 1.06. The antibodies tended to be negative in most antibody-positive people and the GMRT decreased gradually. The antibodies remained negative in most antibody-negative people. After chemotherapy in parasitology confirmed patients, the positive rate for schistosome antibodies decreased from 100% to 20%, and the GMRT decreased from 34.29 to 1.58. There was a highly positive correlation between GMRT and EPG (r = 0.94, P < 0.05).
  
  
  CONCLUSIONS
  The positive rate for schistosome antibodies in population in mountainous schistosomiasis low endemic regions is relatively high (13.67%). The standardization of immunodiagnostic methods is necessary and the suitable diagnostic reagents should be developed in this region.
authors.affiliation: Sichuan Center for Disease Prevention and Control, Chengdu 610041, China.
authors.forename: Zi-Song
authors.initials: ZS
authors.lastname: Wu
authors.forename: Meng
authors.initials: M
authors.lastname: Tang
authors.forename: Han-Gang
authors.initials: HG
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.forename: Hui-Bin
authors.initials: HB
authors.lastname: Zhu
authors.forename: Jian-Ru
authors.initials: JR
authors.lastname: Fan
authors.forename: Ping
authors.initials: P
authors.lastname: Mao
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Mao
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhong
authors.forename: Dong-Chuan
authors.initials: DC
authors.lastname: Qiu
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology* / Q000302:isolation & purification; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007159:Immunologic Tests / Q000379:methods; D010270:Parasite Egg Count / Q000379:methods; D012547:Schistosoma / Q000276:immunology* / Q000302:isolation & purification; D012552:Schistosomiasis / Q000453:epidemiology / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth