title: Adverse events following transarterial chemoembolization for hepatocellular carcinoma and factors predicting such events.
abstract: OBJECTIVE
  To document the adverse events after transarterial chemoembolisation and factors predicting such events.
  
  
  METHODS
  The prospective observational study was conducted at the Sindh Institute of Urology and Transplantation, Karachi, from November 2009 to November 2011. All patients diagnosed as hepatocellular carcinoma were included in this study. Complications developing within the first 6 weeks of the procedure were recorded. SPSS version 16 was used for statistical analysis.
  
  
  RESULTS
  Of the total 80 patients, 59 (73.8%) were male. The overall mean age was 52.25 +/- 9.24 (range: 28-76 years). Most common etiology was hepatitis C related cirrhosis in 55 (68.8%). Adverse events developed in 46 (57.5%) patients. Post transarterial chemoembolisation syndrome was seen in 37 (46.3%). Of those with the syndrome, 24 (64.8%) patients had no additional complications, while 3 (8%) had renal dysfunction, 2 (5%) hypertensive crisis, and 1 (2.7%) patient each had urinary tract infection, pneumonia and sepsis. Decompensation of cirrhosis occurred in 6 (7.5%) patients of whom 3 (50%) developed sepsis and died. The syndrome was associated with tumour size > 5cm (p = 0.001) and higher dose of lipoidol (p = 0.0001). Decompensation of cirrhosis was associated with low basal albumin (p = 0.002), advanced basal child turcotte pugh (p = 0.005) and model for end-stage liver disease (p = 0.006) scores.
  
  
  CONCLUSIONS
  Transarterial chemoembolisation, though generally safe, may lead to serious complications in patients with advanced liver disease. Post-procedure syndrome was associated with increased tumour size and lipoidol dose.
authors.affiliation: Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SLUT), Karachi, Pakistan. draayt@yahoo.com
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Tasneem
authors.forename: Zaigham
authors.initials: Z
authors.lastname: Abbas
authors.forename: Nasir Hassan
authors.initials: NH
authors.lastname: Luck
authors.forename: Syed Mujahid
authors.initials: SM
authors.lastname: Hassan
authors.forename: Syed Muhammad
authors.initials: SM
authors.lastname: Faiq
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects*; D004998:Ethiodized Oil / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents; D004998:Ethiodized Oil