title: Fracture healing in elderly patients: new challenges for antiosteoporotic drugs.
abstract: Osteoporosis is a major public health concern, characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fracture. Fracture repair progresses through different pathways, striking a balance between bone formation and bone remodeling mechanisms. Conventionally, fracture repair is divided into defined stages, each characterized by a specific set of cellular and molecular events. In postmenopausal women and elderly patients, bone healing rates are conditioned by cellular and molecular alterations to bone tissue that result in a progressive deterioration of fracture healing ability. In addition, in elderly patients, comorbidities and drugs therapies may also affect fracture healing. For this reason, pharmacological research is now focused on the possible use of antiosteoporotic drugs to promote bone healing in frail patients.
authors.affiliation: Department of Orthopedic and Traumatology, University of Rome "Tor Vergata", Policlinico Tor Vergata Foundation, Viale Oxford 81, 00133, Rome, Italy, umberto.tarantino@uniroma2.it.
authors.forename: Umberto
authors.initials: U
authors.lastname: Tarantino
authors.forename: Luca
authors.initials: L
authors.lastname: Saturnino
authors.forename: Alessandro
authors.initials: A
authors.lastname: Scialdoni
authors.forename: Maurizio
authors.initials: M
authors.lastname: Feola
authors.forename: Federico Maria
authors.initials: FM
authors.lastname: Liuni
authors.forename: Valerio
authors.initials: V
authors.lastname: Tempesta
authors.forename: Pietro
authors.initials: P
authors.lastname: Pistillo
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001842:Bone and Bones / Q000187:drug effects; D005260:Female; D005593:Fracture Fixation, Internal / Q000379:methods; D017102:Fracture Healing; D016330:Frail Elderly; D006801:Humans; D006810:Humeral Fractures / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy*; D058866:Osteoporotic Fractures / Q000188:drug therapy*; D011859:Radiography; D013876:Thiophenes / Q000627:therapeutic use
chemical_list: D050071:Bone Density Conservation Agents; D013876:Thiophenes; C081587:strontium ranelate