title: Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus.
abstract: Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to infection with LASV and develop lethal disease with pathology similar to that reported in humans.
authors.affiliation: Department of Pathology, Galveston National Laboratory, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA.
authors.forename: Nadezhda E
authors.initials: NE
authors.lastname: Yun
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Seregin
authors.forename: David H
authors.initials: DH
authors.lastname: Walker
authors.forename: Vsevolod L
authors.initials: VL
authors.lastname: Popov
authors.forename: Aida G
authors.initials: AG
authors.lastname: Walker
authors.forename: Jeanon N
authors.initials: JN
authors.lastname: Smith
authors.forename: Milagros
authors.initials: M
authors.lastname: Miller
authors.forename: Juan C
authors.initials: JC
authors.lastname: de la Torre
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Smith
authors.forename: Viktoriya
authors.initials: V
authors.lastname: Borisevich
authors.forename: Joseph N
authors.initials: JN
authors.lastname: Fair
authors.forename: Nadia
authors.initials: N
authors.lastname: Wauquier
authors.forename: Donald S
authors.initials: DS
authors.lastname: Grant
authors.forename: Bayon
authors.initials: B
authors.lastname: Bockarie
authors.forename: Dennis
authors.initials: D
authors.lastname: Bente
authors.forename: Slobodan
authors.initials: S
authors.lastname: Paessler
mesh_terms: D000354:Africa, Western; D000818:Animals; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000821:virology; D007835:Lassa Fever / Q000235:genetics / Q000401:mortality / Q000821:virology*; D007836:Lassa virus / Q000472:pathogenicity*; D051379:Mice; D018345:Mice, Knockout; D053633:Receptor, Interferon alpha-beta / Q000502:physiology; D050794:STAT1 Transcription Factor / Q000502:physiology*; D015996:Survival Rate; D014709:Vero Cells
chemical_list: C508032:Ifnar1 protein, mouse; D050794:STAT1 Transcription Factor; C494080:Stat1 protein, mouse; D053633:Receptor, Interferon alpha-beta
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