title: Use of NMR in profiling of cocaine seizures.
abstract: Cocaine is the most widely used illicit drug, and its origin is always the focus of intense investigation aimed at identifying the trafficking routes. Since NMR represents a unique methodology for performing chemical identification and quantification, here it is proposed a strategy based on (1)H NMR spectral analysis in conjunction with multivariate analysis to identify the chemical "fingerprint" of cocaine samples, and to link cocaine samples based on this information. The most relevant spectral regions containing the fingerprint have been identified: δH 0.86-0.96, 1.50-1.56, 5.90-5.93, 6.48-6.52, 7.31-7.34, 7.61-7.63, 7.68-7.72 ppm. The strategy has been applied on samples seized in different times and places in Naples (Italy). The chemical "fingerprint" depend on what plant they were extracted from, where it was cultivated, and which procedures were used for extraction and purification, thus adding significant information in the process toward identification of the trafficking routes for this drug.
authors.affiliation: Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Pagano
authors.forename: Ilaria
authors.initials: I
authors.lastname: Lauri
authors.forename: Stefano
authors.initials: S
authors.lastname: De Tito
authors.forename: Guido
authors.initials: G
authors.lastname: Persico
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Chini
authors.forename: Anders
authors.initials: A
authors.lastname: Malmendal
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
authors.forename: Antonio
authors.initials: A
authors.lastname: Randazzo
keywords: Cocaine; Multivariate analysis; NMR; Profiling