title: Synthesis of an advanced intermediate of the jatrophane diterpene Pl-4: a dibromide coupling approach.
abstract: The preparation of an advanced intermediate toward the synthesis of the jatrophane diterpene Pl-4 is described. The key step is a regioselective chelation-controlled lithiation of the (Z)-configured bromide in the corresponding vinyl dibromide precursor. The method outlined within this Article is suitable for the facile access of sterically hindered internal vinyl halides for further coupling reactions.
authors.affiliation: Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria.
authors.forename: Rita
authors.initials: R
authors.lastname: Fürst
authors.forename: Uwe
authors.initials: U
authors.lastname: Rinner
mesh_terms: D001965:Bromides / Q000737:chemistry*; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D001965:Bromides; D004224:Diterpenes; C530345:jatrophane
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