title: Isochaetomium A2, a new bis(naphthodihydropyran-4-one) with antimicrobial and immunological activities from fungus Chaetomium microcephalum.
abstract: Isochaetomium A2 (1), a new bis(naphthodihydropyran-4-one), along with chaetochromins A (2) and B (3), was isolated from the solid-state fermented rice culture of Chaetomium microcephalum. The structure of compound 1 was elucidated on the basis of 1D and 2D NMR spectral data, and the relative configuration was confirmed by CD spectrum. Compounds 1-3 possessed significant antimicrobial activity against Escherichia coli 1.044, Staphylococcus aureus 1.252, and Bacillus subtilis 1.079. Moreover, compounds 1-3 showed obvious inhibitory effects on mouse spleen cell proliferation with successive IC50 values of 0.52, 0.19, and 0.24 μM.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, People's Republic of China.
authors.forename: Guo-Bo
authors.initials: GB
authors.lastname: Xu
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Jin-Ku
authors.initials: JK
authors.lastname: Bao
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Fang
authors.forename: Guo-You
authors.initials: GY
authors.lastname: Li
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002597:Chaetomium / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005285:Fermentation; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D012275:Oryza / Q000382:microbiology; D012988:Soil Microbiology; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D002867:Chromones; D007155:Immunologic Factors; C000594171:isochaetomium A2