title: Coupled domino processes: synthesis of 3,5,8-trisubstituted coumarins from propargyl vinyl ethers.
abstract: The generation of a small and representative library of 3,5,8-trisubstituted coumarins (21 compounds, 7 families, 3 groups) is described. The library was built from the corresponding propargyl vinyl ethers and three different 1,3-dicarbonyl derivatives using a one-pot coupled domino strategy. These coumarins constitute a novel chemotype defined by the presence of a chemical handle in the pyranone ring and a varied substitution pattern adorning the aromatic ring, which includes fluorine- or oxygen-containing functionalities.
authors.affiliation: Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Astrofísico Francisco Sánchez 3, 38206, La Laguna, Tenerife, Spain. dtejedor@ipna.csic.es
authors.forename: David
authors.initials: D
authors.lastname: Tejedor
authors.forename: Leandro
authors.initials: L
authors.lastname: Cotos
authors.forename: Fernando
authors.initials: F
authors.lastname: García-Tellado
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D004987:Ethers / Q000737:chemistry*; D015394:Molecular Structure; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D003374:Coumarins; D004987:Ethers; D014753:Vinyl Compounds; C531209:propargyl ether; C100195:vinyl ether