title: Empowering scFv with effector cell functions for improved anticancer therapeutics.
abstract: Single chain variable fragment (scFv) constructs have been an important source of high affinity reagents to target cancer cells. Including an immunoglobulin Fc-binding domain can empower scFvs and other tumor antigen-binding proteins with immune effector cell functions and hence significantly increase their therapeutic potential.
authors.affiliation: Department of Pathology and Lab Medicine; University of Pennsylvania Perelman School of Medicine; Philadelphia, PA USA.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Zhang
keywords: Fc binding; effector cell function; grababody; scFv; tumor
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