title: The antibiotic susceptibility patterns of uropathogenic Escherichia coli, with special reference to the fluoroquinolones.
abstract: BACKGROUND
  The emergence of drug resistance to trimethoprim-sulfamethoxazole, the penicillins, cephalosporins, and fluoroquinolones by Uropathogenic Escherichia coli (UPEC) has limited the options for selecting the appropriate antibiotic for the treatment of urinary tract infections.
  
  
  OBJECTIVE
  The The E. coli isolates, which were obtained from the culture of urine samples,were studied for their antibiotic resistance patterns, with special reference to the antimicrobial activity of the fluoroquinolones and the production of the extended spectrum β-lactamases. (ESBL), Settings and Design: This was a hospital based, prospective study which was done for a period of eighteen months.
  
  
  METHODS
  This study was done by using the standard culture techniques for urine samples, the modified Kirby-Bauer disk diffusion method for the antibiotic susceptibility testing and the disk diffusion method to confirm the ESBL production by the clinical isolates of E. coli in urine. The sensitivity pattern was correlated with the clinical condition and the presence of the risk factors. The statistical analysis which was used: The statistical analysis was done by using the proportions of sensitive, resistant and intermediates. Descriptive statistics like the total, mean and percentage were done by using the Statistical Package for the Social Sciences (SPSS), version 15.0.
  
  
  RESULTS
  The hospital isolates showed high degrees of resistance to the penicillins, cephalosporins, nalidixic acid and the fluoroquinolones, with 59% of the isolates being ESBL producers.
  
  
  CONCLUSIONS
  The incidence of the multidrug resistant strains of Escherichia coli has been steadily increasing over the past few years. The knowledge on the resistance pattern of the bacterial strains in a geographical area will help in guiding the appropriate and the judicious use of antibiotics. Also, the formulation of an appropriate hospital antibiotic policy will go a long way in controlling these infections.
authors.affiliation: Assistant Professor,Department of Microbiology, Bangalore Medical College , Bangalore, India .
authors.forename: Abdul Rahaman
authors.initials: AR
authors.lastname: Shariff V A
authors.forename: Suchitra
authors.initials: S
authors.lastname: Shenoy M
authors.forename: Taruna
authors.initials: T
authors.lastname: Yadav
authors.forename: Radhakrishna
authors.initials: R
authors.lastname: M
keywords: ESBL; Escherichia coli; Fluoroquinolones; UPEC
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