title: Evaluation of acepromazine-induced hemodynamic alterations and reversal with norepinephrine infusion in standing horses.
abstract: The effects of norepinephrine (NOR) infusion on hemodynamic alterations induced with sedative doses of acepromazine (ACP) were evaluated. Infusion of NOR at 1 μg/kg body weight (BW)/minute for 15 min was administered to 5 standing horses 45 min (T45) after intravenous injection of ACP at 0.1 mg/kg BW. Systolic arterial blood pressure (SAP) and hemodynamic parameters were evaluated on the median artery. Parameters were evaluated every 5 min from 45 to 65 min (T65) at 75 (T75), 90 (T90), and 105 (T105) minutes after ACP administration, and the vessel's surface (SURF), diameter (DIAM), circumference (CIRC), peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV), volumetric flow (VF) and resistivity index (RI) of the flow were calculated. Acepromazine induced hypotension and vasodilation with a significant rise in SURF, DIAM, CIRC, PSV, EDV, MV, and VF and a reduction in RI and SAP, which were significantly counteracted from T50 to T60 for EDV, VF, MV and RI, and to T65 for SAP, from T50 to T90 for CIRC and SURF and to T60 for DIAM. These findings demonstrate that a 1 μg/kg BW/minute NOR infusion can reverse ACP's vasodilatory effects, restoring hemodynamic parameters and blood pressure in horses.
authors.affiliation: Equine Clinic, Faculty of Veterinary Medicine, Liège University, Belgium. manuelpequito@ulusofona.pt
authors.forename: Manuel
authors.initials: M
authors.lastname: Pequito
authors.forename: Hélène
authors.initials: H
authors.lastname: Amory
authors.forename: Brieuc
authors.initials: B
authors.lastname: de Moffarts
authors.forename: Valeria
authors.initials: V
authors.lastname: Busoni
authors.forename: Didier
authors.initials: D
authors.lastname: Serteyn
authors.forename: Charlotte
authors.initials: C
authors.lastname: Sandersen
mesh_terms: D000075:Acepromazine / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004336:Drug Antagonism; D005260:Female; D006736:Horses / Q000502:physiology*; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D018492:Dopamine Antagonists; D000075:Acepromazine; D009638:Norepinephrine
references.citation: Acta Vet Scand. 2009 May 07;51:22
references.pmid: 19422714
references.citation: Vet Rec. 2008 Jul 5;163(1):21-5
references.pmid: 18603631
references.citation: J Vet Intern Med. 2006 Nov-Dec;20(6):1437-42
references.pmid: 17186862
references.citation: Crit Care. 2001 Dec;5(6):294-8
references.pmid: 11737909
references.citation: Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1186-92
references.pmid: 10194164
references.citation: Vet Radiol Ultrasound. 2000 Jan-Feb;41(1):64-72
references.pmid: 10695883
references.citation: Minerva Anestesiol. 2009 May;75(5):333-7
references.pmid: 19412154
references.citation: Am J Vet Res. 1994 Apr;55(4):445-9
references.pmid: 8017686
references.citation: Crit Care Med. 1996 Jul;24(7):1150-6
references.pmid: 8674327
references.citation: Am J Vet Res. 1986 May;47(5):1075-8
references.pmid: 3521404
references.citation: Equine Vet J. 2000 Jul;32(4):318-26
references.pmid: 10952381
references.citation: Can Vet J. 1994 Jul;35(7):458-9
references.pmid: 8076296
references.citation: Am J Vet Res. 1994 Mar;55(3):375-8
references.pmid: 8192261
references.citation: Vet Anaesth Analg. 2002 Oct;29(4):159-170
references.pmid: 28404360
references.citation: Res Vet Sci. 1987 May;42(3):318-25
references.pmid: 3616147
references.citation: Vet Anaesth Analg. 2011 Mar;38(2):83-93
references.pmid: 21303439
references.citation: Am J Vet Res. 2006 Oct;67(10):1730-7
references.pmid: 17014324
references.citation: J Vet Pharmacol Ther. 2009 Dec;32(6):541-7
references.pmid: 20444008
references.citation: Vet Anaesth Analg. 2001 Oct;28(4):209
references.pmid: 28404253
references.citation: J Am Soc Nephrol. 2009 May;20(5):933-9
references.pmid: 18799718
references.citation: Vet Clin North Am Equine Pract. 2004 Apr;20(1):77-106
references.pmid: 15062460
references.citation: Aust Vet J. 1982 Nov;59(5):148-52
references.pmid: 6131662
references.citation: Adv Physiol Educ. 2002 Dec;26(1-4):309-16
references.pmid: 12444003
references.citation: Vet Radiol Ultrasound. 2000 Mar-Apr;41(2):168-71
references.pmid: 10779078
references.citation: Am J Vet Res. 1975 Sep;36(9):1299-1303
references.pmid: 1172400
references.citation: Vet Surg. 2007 Dec;36(8):717-23
references.pmid: 18067611
references.citation: Crit Care Med. 1999 Feb;27(2):325-31
references.pmid: 10075057
references.citation: Intensive Care Med. 2005 Nov;31(11):1558-63
references.pmid: 16088408
references.citation: Clin Auton Res. 1992 Apr;2(2):133-5
references.pmid: 1638108
references.citation: Vet Radiol Ultrasound. 2001 Mar-Apr;42(2):93-107
references.pmid: 11327368
references.citation: Vet Anaesth Analg. 2007 Nov;34(6):377-87
references.pmid: 17696976
references.citation: Intensive Care Med. 2003 Oct;29(10):1774-81
references.pmid: 12698246
references.citation: Vet Anaesth Analg. 2005 Mar;32(2):83-93
references.pmid: 15762913