title: Determination of pK(a) of felodipine using UV-Visible spectroscopy.
abstract: In the present study, for the first time, experimental pKa value of felodipine is reported. Dissociation constant, pKa, is one of the very important physicochemical properties of drugs. It is of paramount significance from the perspective of pharmaceutical analysis and dosage form design. The method used for the pKa determination of felodipine was essentially a UV-Visible spectrophotometric method. The spectrophotometric method for the pKa determination was opted by acknowledging the established fact that spectrophotometric determination of pKa produces most precise values. The pKa of felodipine was found to be 5.07. Furthermore, the ruggedness of the determined value is also validated in this study in order to produce exact pKa of the felodipine.
authors.affiliation: Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science, Pilani, Rajasthan 333031, India.
authors.forename: M M
authors.initials: MM
authors.lastname: Pandey
authors.forename: A
authors.initials: A
authors.lastname: Jaipal
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: R
authors.initials: R
authors.lastname: Malik
authors.forename: S Y
authors.initials: SY
authors.lastname: Charde
mesh_terms: D000042:Absorption; D002021:Buffers; D015736:Felodipine / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D015203:Reproducibility of Results; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002021:Buffers; D012996:Solutions; D015736:Felodipine
keywords: Absorbance diagram; Dissociation constant; Felodipine; UV–Visible spectrophotometry; pK(a)