title: Imaging features of sporadic breast cancer in women under 40 years old: 97 cases.
abstract: OBJECTIVE
  To evaluate characteristic features of mammography, ultrasound and magnetic resonance imaging (MRI) of sporadic breast cancer in women <40 years and to determine correlations with pathological and biological factors.
  
  
  METHODS
  A retrospective review of radiological, clinicopathological and biological features of sporadic breast cancers for women under 40 years at our institution between 2007-2012 covering 91 patients. Mammography was available for 97 lesions, ultrasound for 94 and MRI for 38.
  
  
  RESULTS
  The most common imaging features were masses, nearly all classified BI-RADS 4 or 5. On mammography microcalcifications alone accounted for 31 %, all suspicious. There were 42.6 % luminal B, 24.5 % luminal A, 19.1 % HER2-enriched and 10.6 % triple-negative (TN) tumours by immunohistochemistry. HER2 overexpression was correlated with the presence of calcifications at mammography (P = 0.03). TN cancers more often had an oval shape and abrupt interface at ultrasound and rim enhancement on MRI. MRI features were suspicious for all cancers and rim enhancement of a mass was a significant predictor of triple-negative tumours (P = 0.01).
  
  
  CONCLUSIONS
  The imaging characteristics of cancers in patients under 40 years without proven gene mutations do not differ from their older counterparts, but appear correlated to phenotypic profiles, which have a different distribution in young women compared to the general population.
authors.affiliation: Department of Radiology, Institut Bergonié, Comprehensive Cancer Centre, F-33000, Bordeaux, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Bullier
authors.forename: Gaétan
authors.initials: G
authors.lastname: MacGrogan
authors.forename: Hervé
authors.initials: H
authors.lastname: Bonnefoi
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Hurtevent-Labrot
authors.forename: Edouard
authors.initials: E
authors.lastname: Lhomme
authors.forename: Véronique
authors.initials: V
authors.lastname: Brouste
authors.forename: Martine
authors.initials: M
authors.lastname: Boisserie-Lacroix
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002114:Calcinosis / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D044584:Carcinoma, Ductal / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography / Q000379:methods*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012189:Retrospective Studies; D064726:Triple Negative Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D016217:Ultrasonography, Mammary; D055815:Young Adult
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human
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