title: Laryngopharyngeal reflux disease in children.
abstract: Extraesophageal reflux disease, commonly called laryngopharyngeal reflux disease (LPRD), continues to be an entity with more questions than answers. Although the role of LPRD has been implicated in various pediatric diseases, it has been inadequately studied in others. LPRD is believed to contribute to failure to thrive, laryngomalacia, recurrent respiratory papillomatosis, chronic cough, hoarseness, esophagitis, and aspiration among other pathologies. Thus, LPRD should be considered as a chronic disease with a variety of presentations. High clinical suspicion along with consultation with an otolaryngologist, who can evaluate for laryngeal findings, is necessary to accurately diagnose LPRD.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Naren N
authors.initials: NN
authors.lastname: Venkatesan
authors.forename: Harold S
authors.initials: HS
authors.lastname: Pine
authors.forename: Michael
authors.initials: M
authors.lastname: Underbrink
mesh_terms: D002648:Child; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007828:Laryngoscopy; D012307:Risk Factors
keywords: Diagnosis; Extraesophageal reflux disease; Laryngopharyngeal reflux disease
references.citation: Adv Neonatal Care. 2004 Aug;4(4):235-47
references.pmid: 15368216
references.citation: Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004823
references.pmid: 15846735
references.citation: Otolaryngol Head Neck Surg. 1999 Feb;120(2):208-14
references.pmid: 9949354
references.citation: Curr Opin Allergy Clin Immunol. 2006 Feb;6(1):7-11
references.pmid: 16505605
references.citation: J Pediatr Gastroenterol Nutr. 1987 Mar-Apr;6(2):220-4
references.pmid: 3694346
references.citation: Curr Opin Otolaryngol Head Neck Surg. 2010 Dec;18(6):564-70
references.pmid: 20962644
references.citation: Arch Otolaryngol Head Neck Surg. 2005 Jan;131(1):68-70; discussion 71-2
references.pmid: 15655190
references.citation: Int J Pediatr Otorhinolaryngol. 2006 Apr;70(4):579-90
references.pmid: 16359734
references.citation: Ann Otol Rhinol Laryngol. 2000 Oct;109(10 Pt 1):899-905
references.pmid: 11051429
references.citation: Pediatrics. 2010 Apr;125(4):e925-30
references.pmid: 20351005
references.citation: Ann Otol Rhinol Laryngol. 2011 Feb;120(2):116-22
references.pmid: 21391424
references.citation: Arch Otolaryngol Head Neck Surg. 2001 Apr;127(4):369-74
references.pmid: 11296043
references.citation: Int J Pediatr Otorhinolaryngol. 2005 Aug;69(8):1109-12
references.pmid: 15878205
references.citation: Int J Pediatr Otorhinolaryngol. 1997 Aug 20;41(2):145-54
references.pmid: 9306171
references.citation: J Pediatr. 1987 Feb;110(2):181-6
references.pmid: 3806287
references.citation: Ann Otol Rhinol Laryngol. 2000 Nov;109(11):1000-6
references.pmid: 11089989
references.citation: Int J Pediatr Otorhinolaryngol. 1999 Aug 20;49(3):225-30
references.pmid: 10519702
references.citation: Am J Otolaryngol. 2006 May-Jun;27(3):200-3
references.pmid: 16647985
references.citation: Int J Pediatr Otorhinolaryngol. 2007 Sep;71(9):1361-9
references.pmid: 17644193
references.citation: Ann Otol Rhinol Laryngol Suppl. 1997 Jul;169:1-16
references.pmid: 9228867
references.citation: Laryngoscope. 1998 Aug;108(8 Pt 1):1146-9
references.pmid: 9707233
references.citation: Pulm Pharmacol Ther. 2004;17(6):361-8
references.pmid: 15564077
references.citation: Rev Gastroenterol Disord. 2003 Spring;3(2):59-69
references.pmid: 12776003
references.citation: Pediatr Clin North Am. 2003 Apr;50(2):487-502
references.pmid: 12809336
references.citation: Ann Otol Rhinol Laryngol. 1985 Sep-Oct;94(5 Pt 1):516-9
references.pmid: 4051410
references.citation: Am J Med. 2003 Aug 18;115 Suppl 3A:166S-168S
references.pmid: 12928095
references.citation: Int J Pediatr Otorhinolaryngol. 2001 Oct 19;61(1):31-8
references.pmid: 11576629
references.citation: Curr Opin Otolaryngol Head Neck Surg. 2004 Dec;12(6):519-24
references.pmid: 15548911
references.citation: Int J Pediatr Otorhinolaryngol. 1998 Feb;43(1):11-20
references.pmid: 9596365
references.citation: Ear Nose Throat J. 2002 Sep;81(9 Suppl 2):27-31
references.pmid: 12353430
references.citation: Laryngoscope. 2006 Jan;116(1):144-8
references.pmid: 16481828
references.citation: Clin Invest Med. 1990 Oct;13(5):237-46
references.pmid: 2276217
references.citation: Otolaryngol Head Neck Surg. 1999 Jun;120(6):860-4
references.pmid: 10352440
references.citation: Laryngoscope. 2000 Sep;110(9):1560-2
references.pmid: 10983962
references.citation: Eur Arch Otorhinolaryngol. 1999;256(7):370-2
references.pmid: 10473833
references.citation: Laryngoscope. 1968 Nov;78(11):1941-7
references.pmid: 5722897
references.citation: Am J Gastroenterol. 1995 Aug;90(8):1212-20
references.pmid: 7639217
references.citation: Otolaryngol Head Neck Surg. 1999 May;120(5):683-8
references.pmid: 10229593
references.citation: Med J Aust. 2006 Apr 17;184(8):398-403
references.pmid: 16618239
references.citation: Laryngoscope. 2002 Nov;112(11):1926-9
references.pmid: 12439156
references.citation: J Asthma. 2006 Sep;43(7):539-42
references.pmid: 16939995
references.citation: Otolaryngol Head Neck Surg. 2012 Oct;147(4):619-26
references.pmid: 22745201
references.citation: Ann Otol Rhinol Laryngol. 1980 Sep-Oct;89(5 Pt 1):397-400
references.pmid: 7436240
references.citation: J Thorac Cardiovasc Surg. 1986 Apr;91(4):511-7
references.pmid: 3959569
references.citation: Arch Otolaryngol Head Neck Surg. 1998 May;124(5):545-9
references.pmid: 9604981
references.citation: Curr Opin Pulm Med. 2010 Jan;16(1):60-3
references.pmid: 19887939
references.citation: Am J Med. 2000 Mar 6;108 Suppl 4a:131S-138S
references.pmid: 10718466
references.citation: JAMA. 1994 Oct 5;272(13):1025-30
references.pmid: 8089884
references.citation: Ann Otol Rhinol Laryngol. 2007 Aug;116(8):571-5
references.pmid: 17847723
references.citation: Arch Surg. 1984 May;119(5):553-7
references.pmid: 6712468
references.citation: Laryngoscope. 2007 Jun;117(6 Pt 2 Suppl 114):1-33
references.pmid: 17513991
references.citation: Arch Dis Child. 2011 May;96(5):468-72
references.pmid: 20515960
references.citation: Chest. 2009 Sep;136(3):811-815
references.pmid: 19567488
references.citation: Int J Pediatr Otorhinolaryngol. 2005 May;69(5):597-605
references.pmid: 15850681
references.citation: Curr Opin Otolaryngol Head Neck Surg. 2011 Jun;19(3):204-9
references.pmid: 21499103
references.citation: Int J Pediatr Otorhinolaryngol. 2003 Jun;67(6):621-6
references.pmid: 12745155
references.citation: Laryngoscope. 2006 Aug;116(8):1397-403
references.pmid: 16885743
references.citation: Am J Gastroenterol. 2003 Dec;98(12):2616-20
references.pmid: 14687806
references.citation: Int J Pediatr Otorhinolaryngol. 2013 Mar;77(3):341-5
references.pmid: 23277300
references.citation: Digestion. 2004;69 Suppl 1:3-8
references.pmid: 15001829
references.citation: J Laryngol Otol. 1998 Jan;112(1):49-54
references.pmid: 9538446
references.citation: Ann Otol Rhinol Laryngol. 2004 Jun;113(6):488-97
references.pmid: 15224835