title: Testicular inflammation as a new manifestation of IgG4-associated disease.
abstract: IgG4-related disease has properties of a systemic disorder but simultaneously is associated with a growing list of organ-specific manifestations including autoimmune pancreatitis, IgG4-associated cholangitis, IgG4-related kidney disease, and IgG4-associated prostatitis. In this study, we present, to the best of our knowledge, the first case of a patient with multiorgan IgG4-related disease who lost his testes because of IgG4-related testicular inflammation. We postulate that IgG4-related disease in the urogenital tract is not restricted to IgG4-related kidney disease and prostatitis, but that this rare disorder may also affect the testis.
authors.affiliation: Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. L.J.Wenniger@amc.uva.nl
authors.forename: Lucas Maillette
authors.initials: LM
authors.lastname: de Buy Wenniger
authors.forename: Johannes M
authors.initials: JM
authors.lastname: Scheltema
authors.forename: Joanne
authors.initials: J
authors.lastname: Verheij
authors.forename: Ulrich
authors.initials: U
authors.lastname: Beuers
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis; D004823:Epididymitis / Q000276:immunology; D006801:Humans; D006869:Hydronephrosis / Q000150:complications / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D009920:Orchitis / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D010195:Pancreatitis / Q000150:complications / Q000276:immunology; D013737:Testis / Q000276:immunology / Q000473:pathology* / Q000601:surgery
chemical_list: D007074:Immunoglobulin G