title: Personalization of multiple sclerosis treatments: using the chelation therapy approach.
abstract: Though Multiple Sclerosis (MS) sufferers are probably genetically predisposed, toxic metal poisoning (TMP) does seem an increasingly likely environmental trigger. The technique for measuring and clearing TMP was chelation therapy using ethylene-diamine-tetracetic acid (EDTA), which revealed aluminum accumulation in both cases. The first patient, initially benefiting from removing dental fillings that had leaked mercury, also showed gadolinium accumulation from scan contrast medium, and a genomic deficiency of glutathione transferase M1. Glutathione production was impaired and hence also liver detoxification functions. The personal protocol involved glutathione administration and deutrosulfazyme to enhance oxygenation and alleviate oxidative stress. As aluminum began to clear with EDTA infusion, the extracellular/intracellular water ratio was carefully monitored, and carbohydrates limited. In the second case, aluminum poisoning responded to EDTA chelation therapy with eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA), multivitamins, and glutathione administration, again followed by deutrosulfazyme, water ratio control, and dietary correction. The two personalized protocols presented here tend to confirm the hypothesis of TMP as an environmental or iatrogenic trigger for MS, especially when inadequate detoxification lies at the root. Cleansing by chelation therapy, properly understood, can be efficacious, especially bearing in mind the altered cellular water ratio.
authors.affiliation: Charity Association for Person-Centered Medicine, Bologna, Italy. santeguidozanella@gmail.com
authors.forename: Sante Guido
authors.initials: SG
authors.lastname: Zanella
authors.forename: Paolo
authors.initials: P
authors.lastname: Roberti di Sarsina
mesh_terms: D000535:Aluminum / Q000378:metabolism / Q000633:toxicity*; D002614:Chelating Agents / Q000627:therapeutic use*; D015913:Chelation Therapy; D004492:Edetic Acid / Q000627:therapeutic use*; D005260:Female; D005682:Gadolinium / Q000378:metabolism / Q000633:toxicity; D000075322:Heavy Metal Poisoning; D006801:Humans; D008297:Male; D019216:Metals, Heavy / Q000378:metabolism; D009103:Multiple Sclerosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D011041:Poisoning / Q000150:complications / Q000378:metabolism / Q000628:therapy*
chemical_list: D002614:Chelating Agents; D019216:Metals, Heavy; D004492:Edetic Acid; D005682:Gadolinium; D000535:Aluminum
keywords: MS; aluminum poisoning; personalized EDTA chelation