title: Breast cancer metastasis: issues for the personalization of its prevention and treatment.
abstract: Despite important progress in adjuvant and neoadjuvant therapies, metastatic disease often develops in breast cancer patients and remains the leading cause of their deaths. For patients with established metastatic disease, therapy is palliative, with few breaks and with mounting adverse effects. Many have hypothesized that a personalized or precision approach (the terms are used interchangeably) to cancer therapy, in which treatment is based on the individual characteristics of each patient, will provide better outcomes. Here, we discuss the molecular basis of breast cancer metastasis and the challenges in personalization of treatment. The instability of metastatic tumors remains a leading obstacle to personalization, because information from a patient's primary tumor may not accurately reflect the metastasis, and one metastasis may vary from another. Furthermore, the variable presence of tumor subpopulations, such as stem cells and dormant cells, may increase the complexity of the targeted treatments needed. Although molecular signatures and circulating biomarkers have been identified in breast cancer, there is lack of validated predictive molecular markers to optimize treatment choices for either prevention or treatment of metastatic disease. Finally, to maximize the information that can be obtained, increased attention to clinical trial design in the metastasis preventive setting is needed.
authors.affiliation: Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: marinon@mail.nih.gov.
authors.forename: Natascia
authors.initials: N
authors.lastname: Marino
authors.affiliation: Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Stephan
authors.initials: S
authors.lastname: Woditschka
authors.affiliation: Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: L Tiffany
authors.initials: LT
authors.lastname: Reed
authors.affiliation: Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Joji
authors.initials: J
authors.lastname: Nakayama
authors.affiliation: AdvancedBC.org, New York, New York.
authors.forename: Musa
authors.initials: M
authors.lastname: Mayer
authors.affiliation: Michigan Breast Cancer Coalition, Baldwin, Michigan.
authors.forename: Maria
authors.initials: M
authors.lastname: Wetzel
authors.affiliation: Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Patricia S
authors.initials: PS
authors.lastname: Steeg
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis / Q000517:prevention & control* / Q000628:therapy*; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D057285:Precision Medicine
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