title: Effect of selenium and Q10 on the cardiac biomarker NT-proBNP.
abstract: OBJECTIVE
  To investigate whether the effect of 48-month usage of coenzyme Q10 and selenium on cardiac function was different for participants with different levels of cardiac wall tension as measured by plasma levels of N-terminal natriuretic peptide (NT-proBNP) at baseline.
  
  
  METHODS
  A 48-month randomized double-blind controlled trial in a cohort of community-dwelling elderly (mean age 78 years) was carried out. A total of 443 participants were given coenzyme Q10 combined with selenium, or a placebo. NT-proBNP measured at baseline and 48 months was used to evaluate the cardiac wall tension.
  
  
  RESULTS
  After 48 months, supplementation of coenzyme Q10 and selenium had varying impacts depending on the severity of impairment of cardiac function. Analyses of the responses in the different quintiles of baseline NT-proBNP showed that those with active supplementation, and a plasma level of NT-proBNP in the second to fourth quintiles demonstrated significantly reduced NT-proBNP levels (p = 0.022) as well as cardiovascular mortality after 48 months (p = 0.006).
  
  
  CONCLUSIONS
  Long-term supplementation of coenzyme Q10/selenium reduces NT-proBNP levels and cardiovascular mortality in those with baseline NT-proBNP in the second to fourth quintiles indicating those who gain from supplementation are patients with mild to moderate impaired cardiac function.
authors.affiliation: Department of Cardiology, County Council of Östergötland , Linköping , Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Johansson
authors.forename: Örjan
authors.initials: Ö
authors.lastname: Dahlström
authors.forename: Ulf
authors.initials: U
authors.lastname: Dahlström
authors.forename: Urban
authors.initials: U
authors.lastname: Alehagen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012643:Selenium / Q000627:therapeutic use*; D013548:Sweden / Q000453:epidemiology; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D010446:Peptide Fragments; D014815:Vitamins; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014451:Ubiquinone; C024989:coenzyme Q10; D012643:Selenium