title: Acute porphyria presenting as epilepsia partialis continua.
abstract: OBJECTIVE
  The porphyrias are a defect in the biosynthesis of heme which can be associated with different neurological symptoms during acute attacks such as peripheral neuropathy, mental disturbance and seizures. So far, there have only been a few case reports of status epilepticus, none of which were of epilepsia partialis continua (EPC). We present here two cases of hereditary coproporphyria (HCP) manifesting EPC as part of the clinical presentation.
  
  
  METHODS
  The patients' medical charts, EEG and imaging studies were carefully reviewed.
  
  
  RESULTS
  Case 1 is a 49-year-old male who first presented a tonic-clonic seizure. Case 2 is a 30-year-old male who came to the emergency room for a convulsive status epilepticus. Both evolved to EPC over the next days. EPC persisted despite several antiepileptic drug trials. Diagnosis of HCP was confirmed by a high level of urine, fecal and serum porphyrins in both cases and by genetic testing in one. Over the last 3 years, the first patient has continued to present non-disabling EPC and has had four tonic-clonic seizures associated with alcohol consumption. The second patient died from brain edema one month and half after admission.
  
  
  CONCLUSIONS
  Acute porphyrias should be included in the differential diagnosis of new onset status epilepticus, including EPC. Their recognition is important as it modifies significantly patient management, since many anticonvulsants are porphyrogenic.
authors.affiliation: Service de Neurologie, Hôpital Notre-Dame, Centre Hospitalier Universitaire de Montréal, Montréal, Qué., Canada.
authors.forename: Thi Phuoc Yen
authors.initials: TP
authors.lastname: Tran
authors.forename: Karine
authors.initials: K
authors.lastname: Leduc
authors.forename: Martin
authors.initials: M
authors.lastname: Savard
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupré
authors.forename: Donald
authors.initials: D
authors.lastname: Rivest
authors.forename: Dang Khoa
authors.initials: DK
authors.lastname: Nguyen
keywords: Acute porphyria; Epilepsia partialis continua; Status epilepticus
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