title: Ifosfamide induced renal rickets.
abstract: Ifosfamide is commonly used as a chemotherapeutic agent in children. The authors report a 4-y-old boy who developed proximal renal tubulopathy with florid rickets a year after completion of ifosfamide therapy for Ewing's sarcoma. After initiation of treatment, there was complete healing of rickets and he did not need supplements beyond 18 mo. Growth monitoring and musculoskeletal system examination is important in all children who have received ifosfamide therapy. Routine monitoring for nephrotoxicity during and after ifosfamide therapy helps in early identification and intervention.
authors.affiliation: Department of Pediatrics, Pediatric Endocrinology & Pediatric 1, Christian Medical College Hospital, Vellore, Tamil Nadu, 632004, India.
authors.forename: Arul P
authors.initials: AP
authors.lastname: Lionel
authors.forename: Girish
authors.initials: G
authors.lastname: Chinnaswamy
authors.forename: Rikki R
authors.initials: RR
authors.lastname: John
authors.forename: Sarah
authors.initials: S
authors.lastname: Mathai
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy; D002675:Child, Preschool; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000139:chemically induced*; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D012512:Sarcoma, Ewing / Q000188:drug therapy
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide
references.citation: Br J Cancer. 2000 May;82(10):1636-45
references.pmid: 10817497
references.citation: Pediatr Blood Cancer. 2010 Jul 1;54(7):983-9
references.pmid: 20405516
references.citation: Oncology. 2003;65 Suppl 2:7-10
references.pmid: 14586140
references.citation: Drug Metab Dispos. 2005 Jul;33(7):1074-81
references.pmid: 15821045
references.citation: J Clin Oncol. 2009 Nov 10;27(32):5350-5
references.pmid: 19826134
references.citation: Pediatr Blood Cancer. 2007 Apr;48(4):447-52
references.pmid: 16628552
references.citation: J Appl Toxicol. 1997 Jan-Feb;17(1):75-9
references.pmid: 9048231
references.citation: Med Pediatr Oncol. 2003 Sep;41(3):190-7
references.pmid: 12868118
references.citation: Med Pediatr Oncol. 1999 Mar;32(3):177-82
references.pmid: 10064184