title: Gene polymorphism of matrix metalloproteinase-12 and -13 and association with colorectal cancer in Swedish patients.
abstract: BACKGROUND
  It has been widely reported that matrix metalloproteinases (MMPs) have fundamental roles in pathological processes in cancer through degradation of basal membranes and extracellular matrix. For MMP12 and MMP13, a functional single nucleotide polymorphism (SNP) has been detected -82A →G (rs2276109) and -77A →G (rs2252070), respectively. These SNPs are suggested to have an influence on different diseases. The present study evaluated the association between these SNPs in patients with colorectal cancer (CRC) patients and healthy controls.
  
  
  METHODS
  Using the TaqMan system, these SNPs were screened in 385 patients with CRC and 619 controls.
  
  
  RESULTS
  No significant difference in genotype distribution or in allelic frequencies was found between the two groups. However, we showed that the AA MMP-12 genotype is connected with a higher risk of disseminated CRC (Odds Ratio=1.77; 95% Confidence Interval=1.11-2.81, p=0.018).
  
  
  CONCLUSIONS
  The results of this study suggest that the -82A →G (rs2276109) polymorphism of the MMP12 gene reflects clinical outcome of patients with CRC.
authors.affiliation: Department of Natural Science and Biomedicine, University College of Health Sciences, Jönköping, Sweden.
authors.forename: Song
authors.initials: S
authors.lastname: VAN Nguyen
authors.forename: Marita
authors.initials: M
authors.lastname: Skarstedt
authors.forename: Sture
authors.initials: S
authors.lastname: Löfgren
authors.forename: Niklas
authors.initials: N
authors.lastname: Zar
authors.forename: Roland E
authors.initials: RE
authors.lastname: Andersson
authors.forename: Mikael
authors.initials: M
authors.lastname: Lindh
authors.forename: Andreas
authors.initials: A
authors.lastname: Matussek
authors.forename: Jan
authors.initials: J
authors.lastname: Dimberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D053508:Matrix Metalloproteinase 12 / Q000235:genetics*; D053509:Matrix Metalloproteinase 13 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013548:Sweden
chemical_list: C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13; C507122:MMP12 protein, human; D053508:Matrix Metalloproteinase 12
keywords: MMP12; MMP13; SNP; colorectal cancer