title: Association between FAS A670G polymorphism and susceptibility to cervical cancer: evidence from a meta-analysis.
abstract: Previous studies published to evaluate the association between FAS A670G polymorphism and susceptibility to cervical cancer provided conflicting findings. A meta-analysis of published case-control studies was performed to get a comprehensive evidence for the possible association. We searched in PubMed and Wanfang databases for eligible studies published before February 10, 2013. The odds ratio (OR) with 95% confidence interval (95% CI) was used to evaluate the association. Ten studies with a total of 4,904 participants were finally included into the meta-analysis. Overall, there was no obvious association between FAS A670G polymorphism and susceptibility to cervical cancer under all four genetic models (G versus A: OR = 0.97, 95% CI 0.84-1.11, P = 0.64; GG versus AA: OR = 0.92, 95% CI 0.69-1.24, P = 0.60; GG/AG versus AA: OR = 0.99, 95% CI 0.77-1.26, P = 0.92; GG versus AA/AG: OR = 0.92; 95% CI 0.68-1.25, P = 0.59). Subgroup analyses by ethnicity further showed that there was no association between FAS A670G polymorphism and susceptibility to cervical cancer in both Caucasians and Asians. There was no risk of publication bias. In summary, the meta-analysis suggests that there is no association between FAS A670G polymorphism and susceptibility to cervical cancer in both Caucasians and Asians.
authors.affiliation: Department of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.forename: Ning-Xia
authors.initials: NX
authors.lastname: Sun
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics; D019014:fas Receptor / Q000235:genetics*
chemical_list: C491901:FAS protein, human; D019014:fas Receptor
references.citation: Tumour Biol. 2013 Jun;34(3):1659-65
references.pmid: 23494178
references.citation: Hum Cell. 2008 Nov;21(4):95-104
references.pmid: 19067761
references.citation: J Exp Med. 2005 Oct 3;202(7):967-74
references.pmid: 16186185
references.citation: Adv Immunol. 1999;71:163-210
references.pmid: 9917913
references.citation: Immunol Rev. 2006 Oct;213:228-38
references.pmid: 16972907
references.citation: Int J Gynecol Cancer. 2005 Nov-Dec;15 Suppl 3:282-90
references.pmid: 16343245
references.citation: Clin Cancer Res. 2012 Dec 1;18(23):6407-15
references.pmid: 23065429
references.citation: Int J Cancer. 2003 Jan 10;103(2):221-5
references.pmid: 12455036
references.citation: PLoS One. 2013;8(2):e55835
references.pmid: 23431363
references.citation: Eur J Gynaecol Oncol. 2009;30(2):142-4
references.pmid: 19480241
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:179-82
references.pmid: 16515587
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: Lancet. 2007 Sep 8;370(9590):890-907
references.pmid: 17826171
references.citation: J Clin Oncol. 2011 Nov 20;29(33):e812-5
references.pmid: 22025150
references.citation: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references.pmid: 21296855
references.citation: Clin Exp Obstet Gynecol. 2008;35(3):183-6
references.pmid: 18754288
references.citation: Lancet. 2011 Oct 22;378(9801):1461-84
references.pmid: 21924486
references.citation: Blood. 2005 Feb 15;105(4):1396-404
references.pmid: 15486063
references.citation: Lancet. 2011 Nov 26;378(9806):1868-73
references.pmid: 22051739
references.citation: CA Cancer J Clin. 2005 Jan-Feb;55(1):45-54; quiz 57
references.pmid: 15661686
references.citation: BMC Res Notes. 2009 Nov 26;2:238
references.pmid: 19941645
references.citation: Carcinogenesis. 2009 Mar;30(3):487-93
references.pmid: 19168581
references.citation: Cancer Genet Cytogenet. 2008 Jan 1;180(1):1-5
references.pmid: 18068525
references.citation: Ann Intern Med. 2011 Nov 15;155(10):698-705, W216
references.pmid: 22006929
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120