title: [Interobserver reproducibility of Gleason grading in prostate biopsy samples].
abstract: BACKGROUND
  Gleason grading is the most common method of prostate cancer classification.
  
  
  OBJECTIVE
  The aim of the authors was to assess the reproducibility of Gleason grading among pathologists using the same needle biopsy samples.
  
  
  METHODS
  23 pathologists examined 37 prostate cancer biopsies stained with hematoxylin and eosin. Gleason scores were categorised into 4 groups (2-4, 5-6, 7 and 8-10). Kappa statistics were used to reflect interobserver agreement.
  
  
  RESULTS
  Considering all participating pathologists, grouping into one of the 4 categories resulted in an overall kappa value of 0.49. For the individual categories, the worst agreement (kappa = 0.15) was seen with well differentiated carcinomas, and the best (kappa = 0.65) with poorly differentiated ones.
  
  
  CONCLUSIONS
  These results suggest that Gleason grading in biopsy samples is moderately reproducible. The kappa values vary according to the differentiation of the cancer, and there is not much difference between the results of the present study and those published in the literature. To increase reproducibility, trainings should be organised, and this could improve the quality of grading.
authors.affiliation: Bács-Kiskun Megyei Kórház Kecskemét Nyíri. boririta@hotmail.com
authors.forename: Rita
authors.initials: R
authors.lastname: Bori
authors.forename: Ferenc
authors.initials: F
authors.lastname: Salamon
authors.forename: Csaba
authors.initials: C
authors.lastname: Móczár
authors.forename: Gábor
authors.initials: G
authors.lastname: Cserni
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D015588:Observer Variation; D010336:Pathology / Q000592:standards; D010820:Physicians / Q000706:statistics & numerical data*; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D000078329:Workforce