title: Does the bipolar disorder-associated CACNA1C gene confer susceptibility to schizophrenia in Han Chinese?
abstract: The gene coding for the calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) has been reported to be associated with bipolar disorder (BD) in our previous study. Broad evidence suggests some degree of shared genetic susceptibility between BD and schizophrenia. In this study, we aimed to determine whether the BD-associated gene CACNA1C confers susceptibility to schizophrenia. The association was assessed using a cross section study of 696 schizophrenia patients and 1,114 matched control subjects of Han Chinese origin. Between-group comparisons of genotypic or allelic frequencies showed no statistically significant differences. CACNA1C is unlikely to play a major role in the pathophysiology of schizophrenia in Han Chinese. Further large-scale replication studies using a haplotype-tagging single-nucleotide polymorphism selection approach are required to obtain more conclusive results of any potential association.
authors.affiliation: First Geriatric Department, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Cai
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Jianliang
authors.initials: J
authors.lastname: Ni
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Guo
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Weihong
authors.initials: W
authors.lastname: Lu
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics; D020746:Calcium Channels, L-Type / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C079146:CACNA1C protein, human; D020746:Calcium Channels, L-Type
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