title: Polymorphisms in the N acetyltransferase 1 NAT1 gene and lung cancer risk in a minority population.
abstract: One of the most consistently observed exposure-disease relationship is the one between cigarette smoking and lung cancer. Aromatic amines and their metabolites are found in tobacco smoke and may be a class of carcinogen involved in lung carcinogenesis. T he human N -acetyltransferase 1 (NAT 1) enzyme can activate or deactivate aromatic amines, making it a candidate genetic susceptibility gene. We evaluated the potential role of the NAT 1 gene in lung cancer risk in a hospital-based case-control study in a minority population composed of Mexican- and African-Americans. We also assessed the potential interaction between NAT 1 and other environmental exposures such as cigarette smoking. T here was no overall association between the NAT1*10 genotypes and lung cancer risk. T he adjusted odds ratio for the rapid acetylation genotypes was 0 72 (95 % CI 0 37-1 39) for NAT1 defined as the presence of at least one copy of the NAT1*10 allele when compared with all genotypes without the NAT1*10 allele. Analyses by histological subtype or smoking history did not alter these findings. Other NAT 1 alleles will need to be studied for more conclusive results regarding the relevance of NAT 1 activity to lung carcinogenesis.
authors.forename: N
authors.initials: N
authors.lastname: Ishibe
authors.forename: J K
authors.initials: JK
authors.lastname: Wiencke
authors.forename: Z F
authors.initials: ZF
authors.lastname: Zuo
authors.forename: A
authors.initials: A
authors.lastname: McMillan
authors.forename: M R
authors.initials: MR
authors.lastname: Spitz
authors.forename: K T
authors.initials: KT
authors.lastname: Kelsey