title: Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions: potent urease enzyme inhibition and nitric oxide scavenging activities of the products.
abstract: In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC₅₀ value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100 µg/mL.
authors.affiliation: Department of Chemistry, Governament College University, Faisalabad 38000, Pakistan.
authors.forename: Yasmeen
authors.initials: Y
authors.lastname: Gull
authors.forename: Nasir
authors.initials: N
authors.lastname: Rasool
authors.forename: Mnaza
authors.initials: M
authors.lastname: Noreen
authors.forename: Faiz-Ul-Hassan
authors.initials: FU
authors.lastname: Nasim
authors.forename: Asma
authors.initials: A
authors.lastname: Yaqoob
authors.forename: Shazia
authors.initials: S
authors.lastname: Kousar
authors.forename: Umer
authors.initials: U
authors.lastname: Rasheed
authors.forename: Iftikhar Hussain
authors.initials: IH
authors.lastname: Bukhari
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zubair
authors.forename: Md Saiful
authors.initials: MS
authors.lastname: Islam
mesh_terms: D000588:Amines; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D016166:Free Radical Scavengers / Q000737:chemistry; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D014510:Urease / Q000037:antagonists & inhibitors / Q000737:chemistry*
chemical_list: D000588:Amines; D052160:Benzothiazoles; D001897:Boronic Acids; D016166:Free Radical Scavengers; D009569:Nitric Oxide; D010165:Palladium; D014510:Urease
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