title: Prophylaxis and treatment of GVHD: EBMT-ELN working group recommendations for a standardized practice.
abstract: GVHD remains the major impediment to broader application of allogeneic haematopoietic SCT. It can be prevented completely, but at the expense of other complications, rejection, relapse or delayed immune reconstitution. No optimal prevention or treatment method has been defined. This is reflected by enormous heterogeneity in approaches in Europe. Retrospective comparisons between different policies, although warranted, do not give definite answers. In order to improve the present situation, an European Group for Blood and Marrow Transplantation and the European LeukemiaNet working group has developed in a Delphi-like approach recommendations for prophylaxis and treatment of GVHD in the most common allogeneic transplant setting, transplantation from an HLA-identical sibling or unrelated donor for standard risk malignant disease. The working group proposes these guidelines to be adopted as routine standard in transplantation centres and to be used as comparator in systematic studies evaluating the advantages and disadvantages of practices differing from these recommendations.
authors.affiliation: Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Ruutu
authors.affiliation: Hematology, Medical Faculty, University of Basel, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Gratwohl
authors.affiliation: Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: de Witte
authors.affiliation: R. Gorbacheva Memorial Institute of Oncology, Hematology and Transplantation, St Petersburg State Medical I.P.Pavlov University, St Petersburg, Russia.
authors.forename: B
authors.initials: B
authors.lastname: Afanasyev
authors.affiliation: Department of Haematology, Hammersmith Hospital, Imperial College London, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Apperley
authors.affiliation: Division of Hematology, IRCCS San Martino, Genova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bacigalupo
authors.affiliation: Department of Medicine, Imperial College London, Hammersmith Campus, London, UK.
authors.forename: F
authors.initials: F
authors.lastname: Dazzi
authors.affiliation: Department of Medicine V, University of Heidelberg, Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Dreger
authors.affiliation: Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Duarte
authors.affiliation: Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center, Freiburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Finke
authors.affiliation: Service d'Hematologie, Hôpital Saint Antoine, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Garderet
authors.affiliation: Department of Internal Medicine I, Medical University, Vienna, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Greinix
authors.affiliation: Department of Haematology/Oncology, University Hospital Regensburg, Regensburg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Holler
authors.affiliation: Department of Stem Cell Transplantation, University Cancer Centre Hamburg, Hamburg, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Kröger
authors.affiliation: St Anna Children's Hospital, Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Lawitschka
authors.affiliation: Service d'Hématologie Clinique et de Thérapie Cellulaire, Hopital Saint Antoine, Universite Pierre et Marie Curie, INSERM, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Hematology Division, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Nagler
authors.affiliation: Center for Stem Cell Transplantation, University Hospital Basel, Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Passweg
authors.affiliation: Center for Allogeneic Stem Cell Transplantation, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Ringdén
authors.affiliation: Department of Hematology-Transplantation, Saint-Louis Hospital, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Socié
authors.affiliation: Haematology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Sierra
authors.affiliation: Haematology Department, Addenbrookes Hospital, Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Sureda
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Wiktor-Jedrzejczak
authors.affiliation: Anthony Nolan Research Institute, Royal Free Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Madrigal
authors.affiliation: Department of Hematology/Oncology and Hemostasiology, University of Leipzig, Leipzig, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Niederwieser
mesh_terms: D006086:Graft vs Host Disease / Q000517:prevention & control* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014182:Transplantation, Autologous / Q000009:adverse effects*
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