title: Malignancy knows no boundaries.
abstract: A 47-year-old woman presented with ascites. There was history of large volume paracentesis and the drained ascitic fluid was found to be positive for malignant cells. Clinical examination revealed a soft tissue nodule over the skin of right iliac fossa and a small umbilical nodule besides presence of ascites. In addition, the patient had a breast lump of 2×2 cm in upper quadrant of right breast. Biopsy from the abdominal wall nodule revealed a malignant tumour with dense desmoplastic response. The tumour cells were pancytokeratin, CA125, WT1 positive and CDX2, CD10, villin, calretinin negative; thus immunohistochemically suggesting a primary tumor arising from ovary. Biopsy from breast lump showed malignant epithelial cells present in sheets with stromal dysplasia. Immunohistochemically tumour cells were positive for CK7. CA125, WT1, thus favouring a metastatic carcinoma to breast with possible primary arising from ovary.
authors.affiliation: Department of Medical Oncology, Medanta, The Medicity, Gurgaon, Haryana, India. sandeepriya2000@yahoo.com
authors.forename: Sandeep
authors.initials: S
authors.lastname: Batra
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Vaid
authors.forename: Rahul
authors.initials: R
authors.lastname: Bhargava
authors.forename: Amanjeet
authors.initials: A
authors.lastname: Singh
mesh_terms: D001943:Breast Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D012878:Skin Neoplasms / Q000556:secondary*
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