title: Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?
abstract: Terahertz (THz) radiation lies between the infrared and microwave regions of the electromagnetic spectrum and is non-ionizing. We show that exposure of artificial human skin tissue to intense, picosecond-duration THz pulses affects expression levels of numerous genes associated with non-melanoma skin cancers, psoriasis and atopic dermatitis. Genes affected by intense THz pulses include nearly half of the epidermal differentiation complex (EDC) members. EDC genes, which are mapped to the chromosomal human region 1q21, encode for proteins that partake in epidermal differentiation and are often overexpressed in conditions such as psoriasis and skin cancer. In nearly all the genes differentially expressed by exposure to intense THz pulses, the induced changes in transcription levels are opposite to disease-related changes. The ability of intense THz pulses to cause concerted favorable changes in the expression of multiple genes implicated in inflammatory skin diseases and skin cancers suggests potential therapeutic applications of intense THz pulses.
authors.affiliation: Department of Physics, University of Alberta, Edmonton, Alberta, Canada. lyubov.titova@gmail.com
authors.forename: Lyubov V
authors.initials: LV
authors.lastname: Titova
authors.forename: Ayesheshim K
authors.initials: AK
authors.lastname: Ayesheshim
authors.forename: Andrey
authors.initials: A
authors.lastname: Golubov
authors.forename: Rocio
authors.initials: R
authors.lastname: Rodriguez-Juarez
authors.forename: Rafal
authors.initials: R
authors.lastname: Woycicki
authors.forename: Frank A
authors.initials: FA
authors.lastname: Hegmann
authors.forename: Olga
authors.initials: O
authors.lastname: Kovalchuk
mesh_terms: D015536:Down-Regulation / Q000528:radiation effects; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D011565:Psoriasis / Q000378:metabolism*; D011829:Radiation Dosage; D012867:Skin / Q000378:metabolism* / Q000528:radiation effects*; D055053:Terahertz Radiation
chemical_list: D009363:Neoplasm Proteins; D020543:Proteome
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