title: Aging and chronic kidney disease: the impact on physical function and cognition.
abstract: Evidence has recently been building that the presence of chronic kidney disease (CKD) is an independent contributor to decline in physical and cognitive functions in older adults. CKD affects 45% of persons older than 70 years of age and can double the risk for physical impairment, cognitive dysfunction, and frailty. To increase awareness of this relatively new concept of CKD as a risk factor for accelerated aging, we review studies on the association of CKD with physical function, frailty, and cognitive function. We also present a summary of the proposed mechanisms for these associations.
authors.affiliation: MD Division of Nephrology, Stanford University School of Medicine, 777 Welch Road, Suite DE, Room D100, Palo Alto, CA 94304. mktamura@stanford.edu.
authors.forename: Shuchi
authors.initials: S
authors.lastname: Anand
authors.forename: Kirsten L
authors.initials: KL
authors.lastname: Johansen
authors.forename: Manjula
authors.initials: M
authors.lastname: Kurella Tamura
mesh_terms: D000375:Aging / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology; D006233:Persons with Disabilities; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology*
keywords: Chronic kidney disease; Cognitive function.; Frailty; Physical function
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