title: Influence of PLGA concentrations on structural and mechanical properties of carbonate apatite foam.
abstract: Reinforcement with bioresorbable polymer such as PLGA is one of the useful ways to improve the mechanical property of brittle carbonate apatite (CO3Ap) foam. In the present study, CO3Ap foam was reinforced with various concentrations of PLGA solution (5, 10, 15 and 20 wt%) using vacuum infiltration method and its influence on structure, porosity and mechanical property was investigated. It was found that the amount of PLGA inside the hollow space of the CO3Ap foam strut increased with the concentration of PLGA. Porosity likewise was significantly (p<0.05) reduced from 94% (CO3Ap foam without PLGA) down to 82% (CO3Ap foam reinforced with 20 wt% PLGA). Compressive strength of CO3Ap foam significantly (p<0.05) increased from 0.02 MPa (CO3Ap foam without PLGA) up to 1.5 MPa (CO3Ap foam reinforced with 20 wt% PLGA).
authors.affiliation: Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Girlie M
authors.initials: GM
authors.lastname: Munar
authors.forename: Melvin L
authors.initials: ML
authors.lastname: Munar
authors.forename: Kanji
authors.initials: K
authors.lastname: Tsuru
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D000465:Algorithms; D001031:Apatites / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D019245:Compressive Strength; D003799:Dental Stress Analysis / Q000295:instrumentation; D006358:Hot Temperature; D006801:Humans; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011100:Polyglycolic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D013314:Stress, Mechanical; D013499:Surface Properties; D013997:Time Factors; D054457:Tissue Scaffolds / Q000737:chemistry*; D014618:Vacuum
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C485828:alpha-tricalcium phosphate; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C030782:carboapatite