title: Rh(III)-catalyzed halogenation of vinylic C-H Bonds: rapid and general access to Z-halo acrylamides.
abstract: Herein, the regio- and stereoselective iodination, along with some examples for the bromination, of readily available acrylamides to access a variety of differently substituted Z-haloacrylic acid derivatives is reported. The reaction proceeds under mild conditions via a Rh(III)-catalyzed C-H-activation/halogenation mechanism and represents a rare example of a direct halogenation of electron-poor acrylic acid derivatives.
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Nadine
authors.initials: N
authors.lastname: Kuhl
authors.forename: Nils
authors.initials: N
authors.lastname: Schröder
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius