title: Genetic and epigenetic variations in iPSCs: potential causes and implications for application.
abstract: The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine. However, recent studies on the genetic and epigenetic variations in iPSCs have raised concerns that these variations may compromise the utility of iPSCs. In this Perspective, we review the current understanding of genetic and epigenetic variations in iPSCs, trace their causes, discuss the implications of these variations for iPSC applications, and propose approaches to cope with these variations.
authors.affiliation: Howard Hughes Medical Institute, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Gaoyang
authors.initials: G
authors.lastname: Liang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D014644:Genetic Variation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism*; D033581:Stem Cell Transplantation
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