title: Ganglion cell like cells, diagnostic dilemma.
abstract: We report a case of cutaneous swelling found on the left anterior axillary fold of a 41-year-old man. Gross examination of specimen excised from the dermis showed a well-circumscribed nodule histologically composed of spindle cells with interspersed ganglion cell like cells. On hematoxylin and eosine (H and E) staining it was diagnosed as ganglioneuroma. Ganglioneuromas are rare, benign, fully differentiated tumors that contain mature schwann cells, ganglion cells, fibrous tissue, and nerve fibers. They are commonly found along the paravertebral sympathetic ganglia and sometimes in the adrenal medulla. However primary cutaneous ganglioneuroma is an extremely rare tumor. Immunohistochemical workup revealed a fibroblastic origin and hence the case was diagnosed as fibromatosis with ganglion cell like fibroblasts. This case report suggests that the features considered diagnostic of ganglioneuromas can occur in other cutaneous lesions and, therefore, this diagnosis cannot be offered only on the basis of H and E.
authors.affiliation: Department of Pathology, S.N. Medical College, Bagalkot, Karnataka, India.
authors.forename: Anand Shankar
authors.initials: AS
authors.lastname: Ammanagi
authors.forename: Panduranga
authors.initials: P
authors.lastname: Chikkannaiah
authors.forename: Veerabhadrappa Veerappa
authors.initials: VV
authors.lastname: Yenni
authors.forename: Vijay Dhundiraj
authors.initials: VD
authors.lastname: Dombale
keywords: Fibromatosis; ganglion; ganglioneuroma; skin
references.citation: Am J Dermatopathol. 2003 Jun;25(3):239-42
references.pmid: 12775986
references.citation: Cancer. 1954 Sep;7(5):953-78
references.pmid: 13199773
references.citation: J Cytol. 2012 Jan;29(1):57-9
references.pmid: 22438620
references.citation: Am J Surg Pathol. 2001 Nov;25(11):1438-42
references.pmid: 11684963
references.citation: J R Soc Med. 2005 Feb;98(2):63-4
references.pmid: 15684358
references.citation: Cytojournal. 2008 Mar 30;5:5
references.pmid: 18373875
references.citation: J Clin Pathol. 1992 Apr;45(4):353-5
references.pmid: 1577976