title: Associations between bullous pemphigoid and primary malignant cancers: an English national record linkage study, 1999-2011.
abstract: We conducted a nationwide record-linked study using all English NHS hospital admission data and mortality statistics from 1999 to 2011 to evaluate the risk of concurrent or subsequent bullous pemphigoid (BP) in a cohort of 2,873,720 individuals with malignant cancers, when compared with a reference cohort. We calculated standardised rate ratios (RRs) based on person-years at risk, comparing the observed and expected numbers of BP cases in the cancer cohort with those in the reference cohort. Overall, the cohort of people with a record of a malignant cancer was not found to be at greater risk of concurrent or subsequent BP than the cohort of people without a record of a malignant cancer (RR 0.96, 95 % CI 0.88-1.04), although elevated risks of BP were found in sub-cohorts of people with either kidney cancer, laryngeal cancer or lymphoid leukaemia. We also similarly analysed the risk of concurrent and subsequent malignant cancers in a cohort of people with a principal diagnosis of BP, and again found no increased risk as compared with the reference cohort (RR 1.00, 95 % CI 0.92-1.09).
authors.affiliation: Unit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Rosemary Rue Building, Old Road Campus, Oxford, OX3 7LF, UK, Eugene@tutemate.com.
authors.forename: Eugene
authors.initials: E
authors.lastname: Ong
authors.forename: Raph
authors.initials: R
authors.lastname: Goldacre
authors.forename: Uy
authors.initials: U
authors.lastname: Hoang
authors.forename: Rodney
authors.initials: R
authors.lastname: Sinclair
authors.forename: Michael
authors.initials: M
authors.lastname: Goldacre
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008498:Medical Record Linkage; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000453:epidemiology*; D010391:Pemphigoid, Bullous / Q000150:complications / Q000453:epidemiology*; D012306:Risk; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult