title: [Pharmacological therapy of temporomandibular joint pain].
abstract: Pharmacological interventions in temporomandibular joint (TMJ) pain differ from corresponding therapeutic interventions of jaw muscle (myofascial) pain. An actual systematic literature search lists and evaluates available articles on randomised controlled trials for treatment of arthralgia of the TMJ. On the basis of the few available trial reports, non-steroidal anti-inflammatory drugs (NSAIDs) seem to be effective, but side effects and drug interactions need to be considered. In relation to other therapeutic modalities, the rapidity of the onset of action of NSAIDs seems to be different, and the extension of side effects can be varied or reduced by changing the application route (oral versus topical). Palmitoylethanolamide (PEA) as dietary supplement for special medical purposes can apparently evoke positive therapeutic effects in TMJ arthralgia which need to be analysed in further studies.
authors.affiliation: Poliklinik für Zahnärztliche Prothetik, Westdeutsche Kieferklinik, Heinrich-Heine-Universität Düsseldorf. hugger@uni-duesseldorf.de
authors.forename: Alfons
authors.initials: A
authors.lastname: Hugger
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Schindler
authors.forename: Jens C
authors.initials: JC
authors.lastname: Türp
authors.forename: Sybille
authors.initials: S
authors.lastname: Hugger
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000577:Amides; D000700:Analgesics / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D019587:Dietary Supplements; D004347:Drug Interactions; D063388:Endocannabinoids / Q000009:adverse effects / Q000627:therapeutic use; D004983:Ethanolamines / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D017090:Occlusal Splints; D010147:Pain Measurement / Q000187:drug effects; D010169:Palmitic Acids / Q000009:adverse effects / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000577:Amides; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D063388:Endocannabinoids; D004983:Ethanolamines; D010169:Palmitic Acids; C005958:palmidrol
keywords: Arthralgia; Arthralgie; Kiefergelenkschmerz; Myoarthropathie; Therapieempfehlung; kraniomandibuläre Dysfunktion; medikamentöse Behandlung; pharmacological intervention; temporomandibular disorders; temporomandibular joint pain; therapeutic recommendation