title: Virological rebound in human immunodeficiency virus-infected patients with or without residual viraemia: results from an extended follow-up.
abstract: Human immunodeficiency virus (HIV) -infected patients with HIV RNA loads of < 50 copies/mL were followed-up for a median (interquartile range) of 30.8 (11.7-32.9) months to study the effect of residual viraemia (RV) on virological rebound (VR). At baseline, 446 (60.3%) patients had undetectable HIV RNA (group A) and 293 (39.7%) had RV (1-49 HIV RNA copies/mL, group B) by kinetic PCR. VR occurred in 4 (0.9%) patients in group A and in 12 (4.1%) patients in group B (p 0.007). Time to VR was shorter among patients of group B (Log-rank test: p 0.003). However, the proportion of VR was extremely low also among patients with RV.
authors.affiliation: Infectious Diseases Department, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Gianotti
authors.forename: L
authors.initials: L
authors.lastname: Galli
authors.forename: S
authors.initials: S
authors.lastname: Salpietro
authors.forename: M
authors.initials: M
authors.lastname: Cernuschi
authors.forename: S
authors.initials: S
authors.lastname: Bossolasco
authors.forename: M
authors.initials: M
authors.lastname: Maillard
authors.forename: V
authors.initials: V
authors.lastname: Spagnuolo
authors.forename: F
authors.initials: F
authors.lastname: Canducci
authors.forename: M
authors.initials: M
authors.lastname: Clementi
authors.forename: A
authors.initials: A
authors.lastname: Lazzarin
authors.forename: A
authors.initials: A
authors.lastname: Castagna
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D005260:Female; D005500:Follow-Up Studies; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012367:RNA, Viral / Q000097:blood*; D019562:Viral Load; D014766:Viremia
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral
keywords: Antiretroviral therapy; human immunodeficiency virus type 1viral load; kinetic PCR; virological failure; virological rebound