title: Microarc oxidized TiO2 based ceramic coatings combined with cefazolin sodium/chitosan composited drug film on porous titanium for biomedical applications.
abstract: Porous titanium was prepared by pressureless sintering of titanium beads with diameters of 100, 200, 400 and 600 μm. The results indicated that the mechanical properties of porous titanium changed significantly with different bead diameters. Plastic deformations such as necking phenomenon and dimple structure were observed on the fracture surface of porous titanium sintered by beads with diameter of 100 μm. However, it was difficult to find this phenomenon on the porous titanium with a titanium bead diameter of 600 μm. The microarc oxidized coatings were deposited on its surface to improve the bioactivity of porous titanium. Furthermore, the cefazolin sodium/chitosan composited films were fabricated on the microarc oxidized coatings for overcoming the inflammation due to implantation, showing good slow-release ability by addition of chitosan. And the release kinetic process of cefazolin sodium in composited films could be possibly fitted by a polynomial model.
authors.affiliation: Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, PR China. daqingwei@hit.edu.cn
authors.forename: Daqing
authors.initials: D
authors.lastname: Wei
authors.forename: Rui
authors.initials: R
authors.lastname: Zhou
authors.forename: Su
authors.initials: S
authors.lastname: cheng
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.forename: Baoqiang
authors.initials: B
authors.lastname: Li
authors.forename: Yaming
authors.initials: Y
authors.lastname: Wang
authors.forename: Dechang
authors.initials: D
authors.lastname: Jia
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Haifeng
authors.initials: H
authors.lastname: Guo
mesh_terms: D020811:Biomedical Technology / Q000379:methods*; D002118:Calcium / Q000032:analysis; D002437:Cefazolin / Q000494:pharmacology*; D002516:Ceramics / Q000737:chemistry*; D048271:Chitosan / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D016062:Porosity; D013052:Spectrometry, X-Ray Emission; D013314:Stress, Mechanical; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D004364:Pharmaceutical Preparations; C009495:titanium dioxide; D048271:Chitosan; D014025:Titanium; D002437:Cefazolin; D002118:Calcium
keywords: Cefazolin sodium/chitosan; Kinetics; Mechanical properties; Microarc oxidation; Porous titanium