title: Improvement of schistosomal portal hypertensive colopathy after surgical treatment.
abstract: BACKGROUND
  Data on vascular alterations in patients with hepatosplenic schistosomiasis and portal hypertensive colopathy and changes in these after surgery to decrease portal hypertension are limited.
  
  
  OBJECTIVE
  The purpose of this study was to analyse the alterations of portal hypertensive colopathy previously and 6-12 months after splenectomy and gastric devascularization.
  
  
  METHODS
  Twelve patients with hepatosplenic schistosomiasis who also had upper gastrointestinal bleeding were studied prospectively. Their endoscopic findings before and 6-12 months after the surgery were analysed. In addition, mucosal biopsies from ascending colon, sigmoid colon and rectum at these time points were subjected to histological and histomorphometric assessment. It was used a control group due to lack of normal pattern of the histomorphometric measures of vessels in individuals without portal hypertension. The critical level of significance adopted in all tests was of a maximum probability error of 5%.
  
  
  RESULTS
  Surgery did not lead to significant improvement in histological and endoscopic findings. However, on histomorphometry, there was a significant decrease in the area, diameter and thickness of the vessels in mucosa at all colonic sites.
  
  
  CONCLUSIONS
  Surgery for decompression of schistosomal portal hypertension has a beneficial effect on the associated colopathy, being best indicated in patients with gastrointestinal bleeding and esophageal varices.
authors.affiliation: Department of Gastrointestinal Surgery, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil. drangelinamiranda@hotmail.com
authors.forename: Maria Angelina Carvalho
authors.initials: MA
authors.lastname: Miranda
authors.forename: Álvaro Antônio Bandeira
authors.initials: ÁA
authors.lastname: Ferraz
authors.forename: Ana Lúcia Coutinho
authors.initials: AL
authors.lastname: Domingues
authors.forename: Renata Carvalho Miranda
authors.initials: RC
authors.lastname: Chaves
authors.forename: Norma
authors.initials: N
authors.lastname: Jucá
authors.forename: Diógenes Luiz da
authors.initials: DL
authors.lastname: Mota
mesh_terms: D003108:Colonic Diseases / Q000469:parasitology* / Q000601:surgery; D003113:Colonoscopy; D004932:Esophageal and Gastric Varices / Q000469:parasitology* / Q000601:surgery; D006471:Gastrointestinal Hemorrhage / Q000469:parasitology* / Q000601:surgery; D006801:Humans; D006975:Hypertension, Portal / Q000469:parasitology* / Q000601:surgery; D011446:Prospective Studies; D012555:Schistosomiasis mansoni / Q000150:complications* / Q000601:surgery; D012720:Severity of Illness Index; D013156:Splenectomy; D016896:Treatment Outcome