title: Principle and evolving role of intraperitoneal chemotherapy in ovarian cancer.
abstract: BACKGROUND
  Intraperitoneal (i.p.) chemotherapy has been extensively studied in the ovarian cancer field. Despite the fact that three large randomized trials that were conducted in the United States showed survival benefit, meta-analysis also showed survival benefit and the National Cancer Institute (NCI) released a clinical announcement recommending i.p. chemotherapy for optimally debulked advanced stage ovarian cancer in 2006, i.p. chemotherapy has not been widely accepted by the gynecologic oncology community, mainly because of its toxicities.
  
  
  METHODS
  In this review, previously available evidence, new evidence published since the NCI clinical announcement and ongoing clinical trials will be discussed.
  
  
  CONCLUSIONS
  Three currently ongoing randomized Phase III trials will provide extremely important information about whether a less toxic i.p. regimen using carboplatin will be beneficial for patients with advanced ovarian cancer. They are important because it may be possible to solve many of the questions or unmet needs in i.p. chemotherapy by combining these three trials.
authors.affiliation: Saitama Medical University International Medical Center, Department of Gynecologic Oncology, 1397-1 Yamane, Hidaka-City, Saitama 350-1298, Japan. fujiwara@saitama-med.ac.jp
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Shoji
authors.initials: S
authors.lastname: Nagao
authors.forename: Eriko
authors.initials: E
authors.lastname: Aotani
authors.forename: Kosei
authors.initials: K
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000068258:Bevacizumab; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068258:Bevacizumab; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin