title: Macrophages in pancreatic cancer: starting things off on the wrong track.
abstract: Chronic inflammation drives initiation and progression of many malignancies, including pancreatic cancer. In this issue, Liou et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201301001) report that inflammatory macrophages are major players in the earliest stages of pancreatic cancer. They show that paracrine signals from the macrophages activate the nuclear factor κB transcriptional program in normal pancreatic acinar cells, resulting in acinar-ductal metaplasia, a dedifferentiated state that is poised for oncogenic transformation.
authors.affiliation: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Xavier
authors.initials: X
authors.lastname: Deschênes-Simard
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Mizukami
authors.forename: Nabeel
authors.initials: N
authors.lastname: Bardeesy
mesh_terms: D061354:Acinar Cells / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism*
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D020782:Matrix Metalloproteinases
references.citation: Cancer Cell. 2011 Apr 12;19(4):441-55
references.pmid: 21481787
references.citation: Science. 2011 Mar 25;331(6024):1612-6
references.pmid: 21436454
references.citation: Cancer Lett. 2010 Sep 28;295(2):214-28
references.pmid: 20350779
references.citation: Cancer Res. 2012 Mar 1;72(5):1290-300
references.pmid: 22253230
references.citation: Cancer Cell. 2007 Mar;11(3):291-302
references.pmid: 17349585
references.citation: J Clin Invest. 2011 Dec;121(12):4685-99
references.pmid: 22056382
references.citation: Cancer Cell. 2011 Jun 14;19(6):728-39
references.pmid: 21665147
references.citation: Cancer Cell. 2012 Jan 17;21(1):105-20
references.pmid: 22264792
references.citation: Differentiation. 2013 Oct;86(3):126-32
references.pmid: 23660532
references.citation: Cell. 2012 Jan 20;148(1-2):349-61
references.pmid: 22265420
references.citation: Cancer Res. 2007 Oct 1;67(19):9518-27
references.pmid: 17909062
references.citation: Cancer Cell. 2011 Apr 12;19(4):456-69
references.pmid: 21481788
references.citation: J Cell Biol. 2013 Aug 5;202(3):563-77
references.pmid: 23918941
references.citation: Cancer Cell. 2012 Dec 11;22(6):737-50
references.pmid: 23201164
references.citation: Stem Cells. 2013 Aug;31(8):1454-66
references.pmid: 23592398
references.citation: Genes Dev. 2006 Jun 1;20(11):1435-40
references.pmid: 16751181
references.citation: Gastroenterology. 2013 Jun;144(6):1252-61
references.pmid: 23622135
references.citation: Nature. 2008 Jul 24;454(7203):428-35
references.pmid: 18650913
references.citation: Gut. 2012 Dec;61(12):1723-32
references.pmid: 22271799
references.citation: J Clin Invest. 2012 Apr;122(4):1519-28
references.pmid: 22406536