title: The Need for Integrative Computational Oncology: An Illustrated Example through MMP-Mediated Tissue Degradation.
abstract: PHYSICAL ONCOLOGY IS A GROWING FORCE IN CANCER RESEARCH, AND IT IS ENHANCED BY INTEGRATIVE COMPUTATIONAL ONCOLOGY: the fusion of novel experiments with mathematical and computational modeling. Computational models must be assessed with accurate numerical methods on correctly scaled tissues to avoid numerical artifacts that can cloud analysis. Simulation-driven analyses can only be validated by careful experiments. In this perspectives piece, we evaluate a current, widespread model of matrix metalloproteinase-driven tissue degradation during cancer invasion to illustrate that integrative computational oncology may not realize its fullest potential if either of these critical steps is neglected.
authors.affiliation: Center for Applied Molecular Medicine, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Mumenthaler
authors.forename: Gianluca
authors.initials: G
authors.lastname: D'Antonio
authors.forename: Luigi
authors.initials: L
authors.lastname: Preziosi
authors.forename: Paul
authors.initials: P
authors.lastname: Macklin
keywords: cancer; computational oncology; integrative modeling; matrix metalloproteinase; tissue degradation
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