title: [Model of high-fat diet-induced obesity associated to insulin resistance and glucose intolerance].
abstract: OBJECTIVE
  Validate a model of high-fat diet-induced obesity, of low cost, easy reproducibility, that could express characteristics observed in human, and would enable subsequent therapy proposals.
  
  
  METHODS
  Sixteen Swiss mice received a standard diet (DP) or high-fat diet (DH) for 10 weeks.
  
  
  RESULTS
  Although the DP group had greater water (p < 0.01) and feed (p < 0.001) consumption, the DH group had greater body weight (p < 0.5) and adipose tissue gain (p < 0.001), favoring higher adiposity index (p < 0.001), glucose (p < 0.01), and area under the curve in the insulin (p < 0.001) and glucose (p < 0.01) tolerance tests.
  
  
  CONCLUSIONS
  A high-fat diet-induced obesity model has been validated, which was also associated with insulin resistance and glucose intolerance after a period of 10 weeks.
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.
authors.forename: Pollyanna A S
authors.initials: PA
authors.lastname: White
authors.forename: Luana M
authors.initials: LM
authors.lastname: Cercato
authors.forename: Jéssica M D
authors.initials: JM
authors.lastname: Araújo
authors.forename: Lucas A
authors.initials: LA
authors.lastname: Souza
authors.forename: Andréa F
authors.initials: AF
authors.lastname: Soares
authors.forename: Ana Paula O
authors.initials: AP
authors.lastname: Barbosa
authors.forename: José M de R
authors.initials: JM
authors.lastname: Neto
authors.forename: Anderson C
authors.initials: AC
authors.lastname: Marçal
authors.forename: Ubiratan F
authors.initials: UF
authors.lastname: Machado
authors.forename: Enilton A
authors.initials: EA
authors.lastname: Camargo
authors.forename: Márcio R V
authors.initials: MR
authors.lastname: Santos
authors.forename: Luciana C
authors.initials: LC
authors.lastname: Brito
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D004195:Disease Models, Animal; D018149:Glucose Intolerance / Q000209:etiology*; D044882:Glucose Metabolism Disorders / Q000209:etiology*; D007333:Insulin Resistance; D051379:Mice; D009765:Obesity / Q000209:etiology* / Q000503:physiopathology