title: Skeletal involvement in Langerhans cell histiocytosis.
abstract: Langerhans cell histiocytosis (LCH) represents a disorder characterised by an abnormal accumulation of histiocytes in miscellaneous tissues. The bone is commonly affected, especially the flat bones, the spine and the long bones. Some lesions in children such as a "vertebra plana" or a solitary lytic lesion of the skull may be suggestive for LCH, whereas others can be confused with a malignant tumour or osteomyelitis. This pictorial essay presents the main usual and unusual skeletal manifestations observed in LCH.
  
  
  CONCLUSIONS
  • Osseous involvement in children with LCH is very similar to that seen in multiple myeloma. • A solitary lytic lesion of the cranial vault is a typical radiographic finding of LCH. • A vertebra plana appearance in the spine is another typical radiographic finding. • Extensive signal intensity changes within bone marrow on MRI are a helpful sign for the diagnosis. • In long bones, endosteal scalloping may be responsible for a "budding appearance".
authors.affiliation: Department of Pediatric Radiology, Hôpital Jeanne de Flandre, Université de Lille 2, CHRU de Lille, Lille, France.
authors.forename: Suonita
authors.initials: S
authors.lastname: Khung
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Budzik
authors.forename: Elisa
authors.initials: E
authors.lastname: Amzallag-Bellenger
authors.forename: Anne
authors.initials: A
authors.lastname: Lambilliote
authors.forename: Gustavo
authors.initials: G
authors.lastname: Soto Ares
authors.forename: Anne
authors.initials: A
authors.lastname: Cotten
authors.forename: Nathalie
authors.initials: N
authors.lastname: Boutry
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