title: Carotid and brachiocephalic arteries stenosis with long term use of sorafenib.
abstract: The risk associated with arterial thromboembolism (ATE) increases with the presence of anti-vascular endothelial growth factor (VEGF). We are reporting a case of transient ischemic attack (TIA) due to stenosis of the carotid and brachiocephalic arteries following long-term treatment with sorafenib for renal cell carcinoma (RCC). The patient is a non-smoker with no known comorbidities and had no history of cardiovascular disease. The patient underwent a right endarterectomy with angioplasty, aortic arch, and brachiocephalic artery angiogram with a stent placed in the brachiocephalic artery.
authors.affiliation: King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, MBC11, Riyadh 11211, Saudi Arabia. Electronic address: FMARAIKI@kfshrc.edu.sa.
authors.forename: Fatma
authors.initials: F
authors.lastname: Maraiki
authors.affiliation: King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, MBC11, Riyadh 11211, Saudi Arabia.
authors.forename: Ali
authors.initials: A
authors.lastname: Aljubran
mesh_terms: D000792:Angiography; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000473:pathology; D016122:Brachiocephalic Trunk / Q000000981:diagnostic imaging / Q000473:pathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D003251:Constriction, Pathologic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000009:adverse effects / Q000031:analogs & derivatives*; D010671:Phenylurea Compounds / Q000009:adverse effects*; D000077157:Sorafenib; D013848:Thigh / Q000098:blood supply / Q000000981:diagnostic imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D010671:Phenylurea Compounds; D009536:Niacinamide; D000077157:Sorafenib
keywords: Anti-vascular endothelial growth factor (VEGF); Arterial thromboembolism (ATE); Arteries; Atherosclerosis; Brachiocephalic; Carotid; Cumulative dose; Long term; Renal cell carcinoma (RCC); Sorafenib; Stenosis; Stroke; Transient ischemic attack (TIA)