title: [Morphometric analysis of follicular structure of the thyroid gland after chronic low-dose gamma-irradiation].
abstract: A quantitative study of follicle average cross-sectional diameter distribution was conducted in the thyroid gland (TG) of mouse like rodents (25 tundra voles, 24 CBA mice, 16 Wistar rats) after chronic exposure to low-level external y-radiation both in the environment and under the experimental condition (absorbed dose range 0.05-0.5 Gy). Spectrum analysis of TG follicle cross-sectional diameter distribution in the irradiated animals has demonstrated a universal regularity: in comparison with the unirradiated animals there was a significant (1.3-1.7-fold) increase in content of small follicles (with a cross-sectional diameter lower than 36-41 microm in the studied animal species). A similar phenomenon was reproduced in the model experiments (TG regeneration in rats after hemithyroidectomy). The observed activation of the folliculogenesis processes after chronic low-dose irradiation in small doses may be interpreted as a nonspecific adaptive reaction of TG to radiation induced damage of its parenchyma.
authors.forename: A V
authors.initials: AV
authors.lastname: Pavlov
authors.forename: O V
authors.initials: OV
authors.lastname: Ermakova
authors.forename: T V
authors.initials: TV
authors.lastname: Korableva
authors.forename: O V
authors.initials: OV
authors.lastname: Raskosha
mesh_terms: D000818:Animals; D003411:Arvicolinae; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D051379:Mice; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000254:growth & development / Q000528:radiation effects* / Q000648:ultrastructure*