title: A transition-metal-free synthesis of arylcarboxyamides from aryl diazonium salts and isocyanides.
abstract: A transition-metal-free carboxyamidation process, using aryl diazonium tetrafluoroborates and isocyanides under mild conditions, has been developed. This novel conversion was initiated by a base and solvent induced aryl radical, followed by radical addition to isocyanide and single electron transfer (SET) oxidation, affording the corresponding arylcarboxyamide upon hydration of the nitrilium intermediate.
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Xia
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D003979:Diazonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012492:Salts / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D003486:Cyanides; D003979:Diazonium Compounds; D012492:Salts