title: A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis.
abstract: We present a case of a boy who developed obsessive-compulsive disorder (OCD) shortly after an episode of acute disseminated encephalomyelitis (ADEM). To our knowledge, this is the first report of the development of OCD in a child who has had ADEM. This presentation is consistent with our understanding of OCD as a complex genetic disease involving the cerebral white matter tracts, and may indicate a potential pathway for the development of OCD in genetically vulnerable individuals or a shared trigger for the development of pediatric acute-onset neuropsychiatric syndrome and ADEM.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, University of British Columbia, Canada.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Muir
authors.forename: Katherine S
authors.initials: KS
authors.lastname: McKenney
authors.forename: Mary B
authors.initials: MB
authors.lastname: Connolly
authors.forename: S Evelyn
authors.initials: SE
authors.lastname: Stewart
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003337:Corpus Callosum / Q000473:pathology; D004292:Dominance, Cerebral / Q000502:physiology; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000188:drug therapy; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis*; D014888:Wechsler Scales; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone
keywords: demyelinating diseases; obsessive-compulsive disorder; pediatrics