title: Predictors of methamphetamine psychosis: history of ADHD-relevant childhood behaviors and drug exposure.
abstract: The goal of this study was to extend our previous research that reported a significant association between Attention Deficit Hyperactivity Disorder (ADHD)-relevant childhood behaviors and the frequency of methamphetamine (MA)-induced psychotic symptoms in an expanded sample. 190 participants who met DSM-IV criteria for MA dependence were administered the Methamphetamine Experience Questionnaire that assessed MA-induced psychosis. Data related to MA exposure, comorbid drug use, education, familial psychiatric history and assessments of ADHD-relevant childhood behaviors as measured by the Wender Utah Rating Scale (WURS) were collected. Although WURS scores did not differ between 145 MAP+ and 45 MAP- subjects, MAP+ subjects with higher WURS scores were significantly more likely to report more frequent psychosis. Although mean daily MA dosage did not differ between the MAP+ and MAP- subjects, MAP+ subjects who consumed larger doses of MA were significantly more likely to experience frequent psychosis. These data suggest that ADHD-relevant childhood behaviors may interact with MA exposure to reflect a neurobiological vulnerability related to the emergence of frequent MA-induced psychotic symptoms. These results may elucidate factors that contribute to the psychiatric sequelae of MA abuse.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2230 Stockton Blvd, Sacramento, CA 95817, USA; Imaging Research Center, University of California, Davis, 4701 X Street, Sacramento, CA 95817, USA. Electronic address: resalo@ucdavis.edu.
authors.forename: Ruth
authors.initials: R
authors.lastname: Salo
authors.forename: Catherine
authors.initials: C
authors.lastname: Fassbender
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Iosif
authors.forename: Stefan
authors.initials: S
authors.lastname: Ursu
authors.forename: Martin H
authors.initials: MH
authors.lastname: Leamon
authors.forename: Cameron
authors.initials: C
authors.lastname: Carter
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000523:psychology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000523:psychology*; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D011795:Surveys and Questionnaires
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine
keywords: ADHD; Attention; Methamphetamine; Predictors; Prefrontal cortex; Psychosis; Substance abuse
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