title: Tango7 directs cellular remodeling by the Drosophila apoptosome.
abstract: It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling.
authors.affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
authors.forename: Alejandro
authors.initials: A
authors.lastname: D'Brot
authors.forename: Po
authors.initials: P
authors.lastname: Chen
authors.forename: Mahesh
authors.initials: M
authors.lastname: Vaishnav
authors.forename: Shujun
authors.initials: S
authors.lastname: Yuan
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Akey
authors.forename: John M
authors.initials: JM
authors.lastname: Abrams
mesh_terms: D000818:Animals; D053478:Apoptosomes / Q000378:metabolism*; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000235:genetics / Q000378:metabolism*; D020169:Caspases / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology* / Q000201:enzymology*; D005298:Fertility / Q000235:genetics; D014644:Genetic Variation; D008297:Male; D009154:Mutation; D013091:Spermatogenesis / Q000235:genetics; D013094:Spermatozoa / Q000201:enzymology / Q000378:metabolism
chemical_list: D053478:Apoptosomes; D029721:Drosophila Proteins; C542954:eIF3m protein, Drosophila; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D020169:Caspases
keywords: apoptosis; apoptosome; caspase activity; cell death; cellular remodeling
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