title: Determination of vascular permeability coefficients under slow luminal filling.
abstract: This Communication describes a method to obtain the permeability product (permeability coefficient normalized by vascular dimensions) from time-lapse intensity data for which the introduction of labeled solute into the vasculature does not occur at a sharply defined time. This method has an error of ~10% across a wide range of filling times and noise levels, and is particularly well-suited for situations in which the permeability coefficient is greater than 10(-6)cm/s. We show that it is applicable whether the increase in vascular solute concentration is sustained or transient.
authors.affiliation: Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA 02215, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Truslow
authors.forename: Joe
authors.initials: J
authors.lastname: Tien
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000033:anatomy & histology / Q000378:metabolism*; D002199:Capillary Permeability; D003198:Computer Simulation; D006801:Humans; D008955:Models, Cardiovascular; D009716:Numerical Analysis, Computer-Assisted; D013997:Time Factors; D059008:Time-Lapse Imaging
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