title: Anti-obesity effect of Artemisia capillaris extracts in high-fat diet-induced obese rats.
abstract: This study evaluated the anti-obesity effects of Artemisia capillaris extracts in high-fat diet (HFD)-induced obese rats. After six weeks feeding with HFD, Wistar male rats (12-weeks-old) were divided into three groups: HFD-control group and HFD mixed with 0.4% and 0.8% Artemisia capillaris extracts treated groups. After seven weeks of treatments, the body weight gain of the 0.4% and 0.8% A. capillaris extracts treated groups were significantly less than that of the HFD-control group by 11.8% and 15.4%, respectively. Also, A. capillaris extracts treated groups showed significantly lower serum TG, TC and LDL-c levels in a dose-related manner, while causing the reverse effect in serum HDL-c, and exhibited a hepatoprotective effects in vivo, indicated by reduced hepatic lipid contents, and serum ALT and AST levels. These results show that A. capillaris extracts may prevent body weight increases and improve dyslipidemia in HFD-induced obese rats by enhancing their lipid metabolism.
authors.affiliation: Functionality Evaluation Research Group, Korea Food Research Institute, Seongnam 463-746, Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Lim
authors.forename: Yun Tai
authors.initials: YT
authors.lastname: Kim
authors.forename: Yu-Jung
authors.initials: YJ
authors.lastname: Jang
authors.forename: Young-Eon
authors.initials: YE
authors.lastname: Kim
authors.forename: Daeseok
authors.initials: D
authors.lastname: Han
mesh_terms: D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects*; D059305:Diet, High-Fat; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D010936:Plant Extracts
references.citation: Best Pract Res Clin Gastroenterol. 2002 Oct;16(5):709-31
references.pmid: 12406441
references.citation: Planta Med. 2005 Feb;71(2):186-90
references.pmid: 15729631
references.citation: J Biol Chem. 1957 May;226(1):497-509
references.pmid: 13428781
references.citation: Exp Toxicol Pathol. 2013 Sep;65(6):837-44
references.pmid: 23298556
references.citation: Molecules. 2012 Dec 11;17(12):14765-77
references.pmid: 23519251
references.citation: Molecules. 2012 Mar 02;17(3):2518-28
references.pmid: 22388965
references.citation: Zhong Yao Cai. 1998 Aug;21(8):408-11
references.pmid: 12569848
references.citation: J Agric Food Chem. 2002 Jan 2;50(1):81-6
references.pmid: 11754547
references.citation: J Physiol Biochem. 2011 Dec;67(4):569-76
references.pmid: 21656273
references.citation: BMJ. 1996 Feb 24;312(7029):478-81
references.pmid: 8597679
references.citation: Arteriosclerosis. 1988 May-Jun;8(3):207-11
references.pmid: 3370018
references.citation: Br J Pharmacol. 1993 Dec;110(4):1508-14
references.pmid: 8306094
references.citation: J Ethnopharmacol. 2007 Jan 19;109(2):318-24
references.pmid: 16989967
references.citation: J Ethnopharmacol. 2012 Mar 6;140(1):179-85
references.pmid: 22265746
references.citation: Am J Pathol. 2011 Jul;179(1):240-7
references.pmid: 21703406
references.citation: Phytochemistry. 2010 Oct;71(14-15):1625-41
references.pmid: 20732701
references.citation: BMC Evol Biol. 2002 Sep 26;2:17
references.pmid: 12350234
references.citation: Clin Pharmacol Ther. 2011 Jul;90(1):40-51
references.pmid: 21654742
references.citation: Biosci Biotechnol Biochem. 2004 Apr;68(4):942-4
references.pmid: 15118329
references.citation: J Food Sci. 2008 Jan;73(1):T16-20
references.pmid: 18211378
references.citation: J Ethnopharmacol. 1988 Dec;24(2-3):123-6
references.pmid: 3253482
references.citation: J Ethnopharmacol. 2010 Jul 20;130(2):307-14
references.pmid: 20471465
references.citation: Nutrition. 2006 Sep;22(9):956-64
references.pmid: 16814985
references.citation: Prog Lipid Res. 2009 Sep;48(5):275-97
references.pmid: 19464318
references.citation: Eur J Pharmacol. 1992 Jul 21;218(1):123-8
references.pmid: 1327821
references.citation: Obesity (Silver Spring). 2006 Jul;14(7):1118-23
references.pmid: 16899792
references.citation: Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G852-8
references.pmid: 16603729
references.citation: Am J Med Genet A. 2007 Dec 15;143A(24):3016-34
references.pmid: 18000969
references.citation: J Ethnopharmacol. 2008 Jan 17;115(2):263-70
references.pmid: 18023310
references.citation: Eur J Pharmacol. 1991 Jun 6;198(2-3):211-3
references.pmid: 1830846
references.citation: Biochem Pharmacol. 2008 Mar 15;75(6):1402-10
references.pmid: 18237716
references.citation: Int J Mol Med. 2007 Mar;19(3):535-40
references.pmid: 17273805
references.citation: Z Naturforsch C J Biosci. 2007 Jan-Feb;62(1-2):61-4
references.pmid: 17425107
references.citation: J Clin Invest. 2003 Jul;112(1):91-100
references.pmid: 12840063
references.citation: Lancet. 1993 Oct 23;342(8878):1007-11
references.pmid: 8105262
references.citation: PLoS Comput Biol. 2009 Mar;5(3):e1000324
references.pmid: 19325873
references.citation: Eur J Biochem. 1974 Sep 16;47(3):469-74
references.pmid: 4215654
references.citation: Biol Pharm Bull. 2007 Feb;30(2):242-6
references.pmid: 17268059
references.citation: J Ultrastruct Mol Struct Res. 1988 Nov-Dec;101(2-3):109-22
references.pmid: 3268608