title: Association between serum cystatin C levels and cardiovascular disease in type 2 diabetic patients.
abstract: Serum cystatin C concentration was recently reported as a marker of cardiovascular disease (CVD). In the present study, we evaluated the association between the increase of serum cystatin C levels and the risk of CVD in type 2 diabetes. 42 patients with type 2 diabetes were included in the present study; 27 of them have CVD. The control group consisted of 30 healthy adults. Cystatin C, creatinine, microalbuminuria and CRP were measured on Cobas 6000(TM). Cystatine C level was significantly higher in patients with CVD. A significant difference in serum cystatin C was found in patients with and without CVD among albuminuria. No difference in serum cystatin C levels was found according to number of affected vessels. A cystatin C level above 1.10 mg/L was associated with increase of risk of CVD with significant difference (OR = 42.52; IC 95% 1.455 to 1242.827 and p = 0.029). Our results suggested that the increase of serum cystatin C concentrations is a potential marker for CVD in diabetes.
authors.affiliation: Department of biochemistry-toxicology, Fattouma Bourguiba university hospital, Monastir, Tunisia. triki_sony@yahoo.fr
authors.forename: Sonia
authors.initials: S
authors.lastname: Triki
authors.forename: Ons
authors.initials: O
authors.lastname: Fekih
authors.forename: Ilhem
authors.initials: I
authors.lastname: Hellara
authors.forename: Fadoua
authors.initials: F
authors.lastname: Neffati
authors.forename: Wahiba
authors.initials: W
authors.lastname: Douki
authors.forename: Khaldoun Ben
authors.initials: KB
authors.lastname: Hamda
authors.forename: Faouzi
authors.initials: F
authors.lastname: Maatouk
authors.forename: Mohamed Fadhel
authors.initials: MF
authors.lastname: Najjar
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000652:urine; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood*; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D013972:Thyrotropin; D002097:C-Reactive Protein; D003404:Creatinine
keywords: cardiovascular disease; cystatin C; microalbuminuria; type 2 diabete