title: Cardiac condition in young chagasic women.
abstract: BACKGROUND
  Chagas disease is a complex disorder caused by Trypanosoma cruzi. Most patients remain asymptomatic for several years and 30% of them progress quietly to developing cardiomyopathy. The factors that lead to chronic myocardial lesions are not fully understood.
  
  
  OBJECTIVE
  To investigate the association between clinical symptoms and single nucleotide polymorphisms in chagasic and non-chagasic women younger and older than 55 years of age.
  
  
  RESULTS
  we analyzed Ala-9Val and Ile58Thr polymorphisms of the SOD-Mn gene, 138ex1ins/del A of the endothelin-1 gene (ET-1) and H323H (T/C) of the endothelin receptor A gene (ETA), by PCR-RFLP using genomic DNA from leukocyte of 85 women. We also evaluated serum lipid profile, renal and liver function, chest X-rays, electrocardiograms (ECGs) and echocardiography (EchoCG). Biochemical profiling did not show differences between chagasic and non-chagasic patients. The polymorphisms analyses showed a significant association in the distribution of frequencies of the Mn-SOD Ile58Thr gene between both groups. Young chagasic patients had a significantly higher prevalence of abnormalities in X-rays, in ECGs and they showed grade II and III of NYHA functional classes. The chance of having an abnormal EchoCG was 5.87 higher in young chagasic patients (OR=5.87, 95% CI 1.47-23.4).
  
  
  CONCLUSIONS
  We concluded that the parasite affects young females by accelerating the deterioration of cardiac function, independent of other cardiovascular risk factors and the cardioprotective action of estrogens present in the premenopausal stage.
authors.affiliation: Semiology Department UHMI 3, Chagas and Hypertension Office, Cordoba Hospital, Argentine.
authors.forename: O
authors.initials: O
authors.lastname: Lassen
authors.forename: G
authors.initials: G
authors.lastname: Dotto
authors.forename: S
authors.initials: S
authors.lastname: Ojeda
authors.forename: A
authors.initials: A
authors.lastname: Garutti
authors.forename: P
authors.initials: P
authors.lastname: Bertolotto
authors.forename: S
authors.initials: S
authors.lastname: Tabares
authors.forename: R
authors.initials: R
authors.lastname: Gallerano
authors.forename: A
authors.initials: A
authors.lastname: Sembaj
mesh_terms: D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000378:metabolism / Q000469:parasitology*; D014355:Chagas Disease / Q000150:complications*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D017697:Premenopause; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism
chemical_list: D013482:Superoxide Dismutase
keywords: EchoCG alterations; chagasic disease; premenopausal women
references.citation: Exp Mol Pathol. 2002 Dec;73(3):230-3
references.pmid: 12565798
references.citation: Cardiovasc Res. 2006 Mar 1;69(4):836-44
references.pmid: 16403479
references.citation: Am J Cardiol. 2001 May 15;87(10):1217-20; A7
references.pmid: 11356406
references.citation: Clin Chim Acta. 2004 Jul;345(1-2):151-9
references.pmid: 15193990
references.citation: Rev Esp Cardiol. 2009 Nov;62(11):1211-6
references.pmid: 19889330
references.citation: Biochem Biophys Res Commun. 1999 Aug 2;261(2):332-9
references.pmid: 10425186
references.citation: Cardiology. 2006;105(4):246-52
references.pmid: 16582543
references.citation: Rev Saude Publica. 2002 Dec;36(6):755-8
references.pmid: 12488945
references.citation: Free Radic Biol Med. 2006 Jul 15;41(2):270-6
references.pmid: 16814107
references.citation: Arch Med Res. 1998 Autumn;29(3):241-6
references.pmid: 9775458
references.citation: N Engl J Med. 2002 Dec 12;347(24):1916-23
references.pmid: 12477941