title: [Dynamics of IL-22-producing cells of mice infected with Schistosoma japonicum].
abstract: OBJECTIVE
  To study the dynamics of IL-22-producing cells and analyze the main source of IL-22 of mice infected with Schistosoma japonicum.
  
  
  METHODS
  The lymphocytes and splenocytes were prepared from lymphnodes and spleens of mice with S. japonicum infection at different stages (0 w, 3 w, 5w, 8 w, 13 w after infection). The proportions of IL-22-producing cells were determined by FACS.
  
  
  RESULTS
  The proportions of IL-22-producing cells increased significantly in the lymphocytes and splenocytes from the mice infected with S. japonicum. The IL-22-producing T cells accounted 80% of the total IL-22-producing cells. The IL-22-producing CD4- T cells increased obviously in the 3rd week after S. japonicum infection. However, the proportion of the IL-22-producing CD4+ T cells began to rise since the 3rd week post-infection, and increased significantly at the 8th week after infection.
  
  
  CONCLUSIONS
  In the lymphnodes and spleens of mice infected with S. japonicum, IL-22 is produced by both T cells and non-T cells, and T cells are the most important source of IL-22. The IL-22-producing CD4- T cells increase rapidly in the early acute inflammatory response, and the IL-22-producing CD4+ T cells increase significantly during the chronic inflammatory phase.
authors.affiliation: Department of Pathogen Biology, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Yang
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Dong
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Chen
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Xu
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Zhang
authors.forename: Xue
authors.initials: X
authors.lastname: Xue
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Kong
authors.forename: Sha
authors.initials: S
authors.lastname: Zhou
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Chuan
authors.initials: C
authors.lastname: Su
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000469:parasitology; D005260:Female; D007378:Interleukins / Q000096:biosynthesis* / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012549:Schistosoma japonicum / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000276:immunology* / Q000469:parasitology; D013154:Spleen / Q000276:immunology / Q000469:parasitology; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D000097043:Interleukin-22