title: Asthma and risk of selective IgA deficiency or common variable immunodeficiency: a population-based case-control study.
abstract: OBJECTIVE
  To determine the association between a history of asthma and a diagnosis of selective IgA deficiency (sIgAD)/common variable immunodeficiency (CVID).
  
  
  METHODS
  This population-based case-control study included residents of Olmsted County, Minnesota, who met the Pan-American Group for Immunodeficiency/European Society for Immunodeficiencies diagnostic criteria for sIgAD/CVID between January 1, 1964, through December 31, 2008. Each case had 4 age- and sex-matched controls (2 from the community and 2 from a list of individuals who had undergone an immune work-up). We ascertained asthma status by applying predetermined criteria for asthma.
  
  
  RESULTS
  We identified 39 cases: 26 (66.7%) had sIgAD and 13 (33.3%) had CVID. Of the 39 cases, 51.3% were men (n=20) and 97.1% were white (33 of 34 patients). The mean age at the index date (the time when criteria were met) of sIgAD/CVID was 34.2 years. Of the 39 cases, 9 (23.1%) had a history of asthma before the index date of sIgAD/CVID; of the 156 controls, 16 (10.3%) had a history of asthma before the index date (odds ratio, 2.77; 95% CI, 1.09-7.06; P=.03). A history of asthma (before or after the index date of sIgAD/CVID) was more prevalent in sIgAD/CVID cases (30.8%; n=12) than in matched controls (11.5%; n=18) (odds ratio, 3.57; 95% CI, 1.50-8.51; P=.01).
  
  
  CONCLUSIONS
  Asthmatic patients are more likely to have a diagnosis of sIgAD/CVID than nonasthmatic individuals. This association may potentially account for the increased risks of bacterial infections in some individuals with asthma.
authors.affiliation: Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Department of Preventive Medicine, Medical College, Inje University, Busan, South Korea.
authors.forename: Sang-Hwa
authors.initials: SH
authors.lastname: Urm
authors.forename: Hyun Don
authors.initials: HD
authors.lastname: Yun
authors.forename: Yilma A
authors.initials: YA
authors.lastname: Fenta
authors.forename: Kwang Ha
authors.initials: KH
authors.lastname: Yoo
authors.forename: Roshini S
authors.initials: RS
authors.lastname: Abraham
authors.forename: John
authors.initials: J
authors.lastname: Hagan
authors.forename: Young J
authors.initials: YJ
authors.lastname: Juhn
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D016022:Case-Control Studies; D017074:Common Variable Immunodeficiency / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D015166:Monitoring, Immunologic; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors
keywords: CVID; ESID; European Society for Immunodeficiencies; OR; PAGID; PID; Pan-American Group for Immunodeficiency; common variable immunodeficiency; odds ratio; primary immunodeficiency; sIgAD; selective IgA deficiency
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