title: Respiratory infections in adults with atopic disease and IgE antibodies to common aeroallergens.
abstract: BACKGROUND
  Atopic diseases, including allergic rhinitis, allergic dermatitis and asthma, are common diseases with a prevalence of 30-40% worldwide and are thus of great global public health importance. Allergic inflammation may influence the immunity against infections, so atopic individuals could be susceptible to respiratory infections. No previous population-based study has addressed the relation between atopy and respiratory infections in adulthood. We assessed the relation between atopic disease, specific IgE antibodies and the occurrence of upper and lower respiratory infections in the past 12 months among working-aged adults.
  
  
  RESULTS
  A population-based cross-sectional study of 1008 atopic and non-atopic adults 21-63 years old was conducted. Information on atopic diseases, allergy tests and respiratory infections was collected by a questionnaire. Specific IgE antibodies to common aeroallergens were measured in serum. Adults with atopic disease had a significantly increased risk of lower respiratory tract infections (LRTI; including acute bronchitis and pneumonia) with an adjusted risk ratio (RR) 2.24 (95% confidence interval [CI] 1.43, 3.52) and upper respiratory tract infections (URTI; including common cold, sinusitis, tonsillitis, and otitis media) with an adjusted RR 1.55 (1.14, 2.10). The risk of LRTIs increased with increasing level of specific IgE (linear trend P = 0.059).
  
  
  CONCLUSIONS
  This study provides new evidence that working-aged adults with atopic disease experience significantly more LRTIs and URTIs than non-atopics. The occurrence of respiratory infections increased with increasing levels of specific IgE antibodies to common aeroallergens, showing a dose-response pattern with LRTIs. From the clinical point of view it is important to recognize that those with atopies are a risk group for respiratory infections, including more severe LRTIs.
authors.affiliation: Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland.
authors.forename: Aino
authors.initials: A
authors.lastname: Rantala
authors.forename: Jouni J K
authors.initials: JJ
authors.lastname: Jaakkola
authors.forename: Maritta S
authors.initials: MS
authors.lastname: Jaakkola
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications* / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D062486:Public Health Surveillance; D015203:Reproducibility of Results; D012141:Respiratory Tract Infections / Q000150:complications*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
references.citation: Allergy. 1998 Aug;53(8):763-8
references.pmid: 9722225
references.citation: Am J Epidemiol. 2006 Oct 15;164(8):742-9
references.pmid: 16877535
references.citation: Lancet. 2002 Mar 9;359(9309):831-4
references.pmid: 11897281
references.citation: Am J Epidemiol. 2003 Nov 15;158(10):981-7
references.pmid: 14607806
references.citation: Clin Exp Immunol. 2008 Sep;153 Suppl 1:22-6
references.pmid: 18721325
references.citation: Allergy. 2007 Sep;62(9):1087-90
references.pmid: 17578494
references.citation: Pediatr Allergy Immunol. 2006 Aug;17(5):389-91
references.pmid: 16846459
references.citation: J Allergy Clin Immunol. 2006 Mar;117(3):642-8
references.pmid: 16522465
references.citation: Am J Epidemiol. 1999 Dec 1;150(11):1223-8
references.pmid: 10588083
references.citation: PLoS One. 2011;6(12):e27912
references.pmid: 22205932
references.citation: Am J Epidemiol. 1995 Apr 15;141(8):755-65
references.pmid: 7709918
references.citation: Arch Otolaryngol Head Neck Surg. 2000 Oct;126(10):1201-6
references.pmid: 11031406
references.citation: Environ Health Perspect. 2002 May;110(5):543-7
references.pmid: 12003761
references.citation: Am J Public Health. 2003 Dec;93(12):2055-60
references.pmid: 14652334
references.citation: Allergy. 2010 Nov;65(11):1351-6
references.pmid: 20659076
references.citation: N Engl J Med. 2001 Jan 4;344(1):30-7
references.pmid: 11136958
references.citation: Br J Dermatol. 1975 Jun;92(6):611-8
references.pmid: 1101939
references.citation: Toxicol Pathol. 2012;40(2):312-4
references.pmid: 22222885
references.citation: Eur Respir J. 2004 Nov;24(5):734-9
references.pmid: 15516665
references.citation: J Allergy Clin Immunol. 2002 May;109(5):784-8
references.pmid: 11994700
references.citation: J Allergy Clin Immunol. 2010 Jan;125(1):217-21
references.pmid: 20109748
references.citation: J Allergy Clin Immunol. 1993 Nov;92(5):757-66
references.pmid: 8227868