title: Conflict of interest in the assessment of hyaluronic acid injections for osteoarthritis of the knee: an updated systematic review.
abstract: The search results of a recent systematic review of prospective, randomized, placebo-controlled trials on hyaluronic acid injections for knee arthritis were updated and reviewed for funding source and qualitative conclusions. Forty-eight studies were identified; 30 (62.5%) were industry funded, and 3 (6.25%) were not. Fifteen (31.3%) studies did not identify a funding source. An association was observed between a reported potential financial conflict of interest of the author and the qualitative conclusion (P=0.018). None of the studies with a reported financial conflict of interest of at least one author had an unfavorable conclusion; 11 (35%) of the 31 studies with no industry-affiliated authors indicated that hyaluronic acid injection for knee osteoarthritis was no more effective than a placebo injection.
authors.affiliation: Department of Orthopaedic Surgery, University of Michigan, 2912 Taubman Center, Ann Arbor, Michigan.
authors.forename: Jonathon O
authors.initials: JO
authors.lastname: Printz
authors.forename: John J
authors.initials: JJ
authors.lastname: Lee
authors.forename: Michael
authors.initials: M
authors.lastname: Knesek
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Urquhart
mesh_terms: D016265:Conflict of Interest / Q000191:economics*; D004345:Drug Industry / Q000191:economics; D037921:Gift Giving; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007270:Injections, Intra-Articular; D020370:Osteoarthritis, Knee / Q000188:drug therapy* / Q000191:economics; D063868:Patient Outcome Assessment; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D006820:Hyaluronic Acid
keywords: hyaluronic acid injections; knee osteoarthritis; systematic review