title: A Critical Evaluation and Comparison of Antimicrobial Prophylaxis in Elective Surgeries Across three Hospitals.
abstract: OBJECTIVE
  1. To evaluate and compare the pattern and rationality of prophylactic antimicrobial therapy in elective surgeries. 2. To evaluate and compare the adherence of hospitals to the standard guidelines on prophylactic antimicrobial therapy.
  
  
  METHODS
  A total of 150 patients each from a government hospital (group I), medical college teaching hospital (group II), and corporate hospital attached to the institution (group III) who had undergone elective, non-complicated surgery were included. The number & types of antimicrobials used along with duration were noted. Rationality was assessed on the basis of Kunin's criteria, ASHP guidelines & SIGN guidelines. Statistical analysis was done using appropriate tests.
  
  
  RESULTS
  Cephalosporins were the most commonly used antimicrobials in all three groups (52.6%,85.7% & 84.8% respectively) followed by nitroimidazoles. Antimicrobial prophylaxis was appropriate in only 14.1%, 23.3% & 32.9% cases in the three groups respectively (p<0.01).The most common problem was prolonged duration of administration in 50.3%,58% & 45% respectively. The implementation of prophylaxis with respect to regimen & duration was erroneous in 20.1%, 12.7% & 4.7% respectively (p<0.01).
  
  
  CONCLUSIONS
  The rationality & regimen of antimicrobial prophylaxis was comparatively better in the corporate hospital followed by medical college hospital and the government hospital. The present study calls for an urgent review on rational use of antimicrobials for prophylaxis in all the 3 hospitals.
authors.affiliation: Post Graduate Student, Department of Pharmacology, Kasturba Medical College , Mangalore, Manipal University India .
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Belagali
authors.forename: Alwar
authors.initials: A
authors.lastname: Mc
authors.forename: Poornachandra
authors.initials: P
authors.lastname: Thejeswi
authors.forename: Ullal
authors.initials: U
authors.lastname: Sheetal D
authors.forename: Vani
authors.initials: V
authors.lastname: Bhagwath
authors.forename: Ashok
authors.initials: A
authors.lastname: Shenoy K
authors.forename: Mukta
authors.initials: M
authors.lastname: Chowta
authors.forename: Sahana D
authors.initials: SD
authors.lastname: Acharya
keywords: ASHP guidelines; Antimicrobial prophylaxis; Kunin’s criteria; Rational antimicrobial use; SIGN guidelines
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