title: Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia.
abstract: A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Richter
authors.forename: Pär
authors.initials: P
authors.lastname: Halje
authors.forename: Per
authors.initials: P
authors.lastname: Petersson
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000009:adverse effects*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D010300:Parkinson Disease / Q000188:drug therapy
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa