title: [Relationship of oxidative stress and weight loss achieved in morbid obese patients by means of bariatric surgery using the duodenal switch technique].
abstract: BACKGROUND
  Oxidative stress (OS), which is overtly present in morbid obesity, is an indicator of a chronic inflammatory state associated to obesity and possibly related with the associated comorbidities, some of which represent an important risk factor for the occurrence of cardiovascular diseases, so that decreasing its intensity has become a treatment priority.
  
  
  METHODS
  he have consecutively performed the duodenal crossing surgical technique in 28 patients suffering from morbid obesity, assessing the level of oxidative stress by the determination of the products of molecular oxidation and antioxidants before the surgery and throughout one year after the surgery. Weight evolution and the progression of the comorbidities already present were assessed.
  
  
  RESULTS
  the mean age of the patients in this series was 43 ± 1 years and the mean BMI 50.3. 82% had associated comorbidities. After the surgery, all the patients progressively lost weight throughout the study period, with a parallel improvement of the comorbidities and a progressive decrease in OS values and improvement of the antioxidant systems, the OS values being similar to those of a normal population at the end of the study.
  
  
  CONCLUSIONS
  The weight loss achieved allows improving the comorbidities and the oxidative stress values so that at the end of the study the results obtained are similar to those of a normal population.
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Leonardo
authors.initials: L
authors.lastname: De Tursi Ríspoli
authors.forename: Antonio
authors.initials: A
authors.lastname: Vázquez Tarragón
authors.forename: Antonio
authors.initials: A
authors.lastname: Vázquez Prado
authors.forename: Guillermo
authors.initials: G
authors.lastname: Sáez Tormo
authors.forename: Ali Ismail
authors.initials: AI
authors.lastname: Mahmoud
authors.forename: Marcos
authors.initials: M
authors.lastname: Bruna Esteban
authors.forename: Claudia
authors.initials: C
authors.lastname: Mulas Fernández
authors.forename: Verónica
authors.initials: V
authors.lastname: Gumbau Puchol
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015992:Body Mass Index; D004386:Duodenum / Q000601:surgery*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism / Q000601:surgery*; D018384:Oxidative Stress / Q000502:physiology*; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*
chemical_list: D005978:Glutathione