title: Association of STAT4 rs7574865 with susceptibility to systemic lupus erythematosus in Iranian population.
abstract: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex genetic inheritance that affecting different organs and systems. STAT4 has been newly identified as a susceptible gene in the development of SLE. According to recent studies, STAT4 has been associated with SLE in various populations. We investigated whether STAT4 single nucleotide polymorphisms (SNPs) were associated with susceptibility and clinical features of SLE in Iranian patients. The study group comprised 280 patients with SLE and 281 sex-, age-, and ethnicity-matched healthy controls of Iranian ancestry. Two SNPs (rs7574865 and rs7601754) were genotyped using the TaqMan MGB Allelic Discrimination method. Our results showed a significant association between rs7574865 T allele (odds ratio (OR) = 1.50, 95 % CI = 1.18-1.92, P = 0.002) and susceptibility to SLE. The rs7574865TT genotype (P = 0.02, OR = 1.94, 95 % CI = 1.74-3.19) and GT genotype (P = 0.008, OR = 1.71, 95 % CI = 1.19-2.45) showed a significant association with the risk of SLE in the Iranian population. We concluded that STAT4 rs7574865 is associated with SLE susceptibility in the Iranian population and this SNP might be a factor in the pathogenesis of SLE. However, further studies are required to investigate the mechanism by which polymorphisms in this gene lead to SLE.
authors.affiliation: Immunology Department, Shahid Sadoughi University of Medical Sciences (International Campus), Yazd, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Mirkazemi
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Akbarian
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Jamshidi
authors.forename: Reza
authors.initials: R
authors.lastname: Mansouri
authors.forename: Shima
authors.initials: S
authors.lastname: Ghoroghi
authors.forename: Yahya
authors.initials: Y
authors.lastname: Salimi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Tahmasebi
authors.forename: Mahdi
authors.initials: M
authors.lastname: Mahmoudi
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007492:Iran; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D050797:STAT4 Transcription Factor / Q000235:genetics*
chemical_list: D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human
references.citation: J Immunol. 2004 Jun 1;172(11):6775-82
references.pmid: 15153495
references.citation: Blood. 2003 Dec 1;102(12):4084-9
references.pmid: 12893768
references.citation: Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5
references.pmid: 12604793
references.citation: Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12281-6
references.pmid: 12213961
references.citation: Immunol Rev. 2004 Dec;202:139-56
references.pmid: 15546391
references.citation: Genes Immun. 2011 Jan;12(1):51-8
references.pmid: 20962850
references.citation: Hum Mol Genet. 2008 Sep 15;17(18):2868-76
references.pmid: 18579578
references.citation: Arthritis Rheum. 2003 Sep;48(9):2396-401
references.pmid: 13130457
references.citation: Arthritis Rheum. 1996 Mar;39(3):363-9
references.pmid: 8607884
references.citation: Nat Genet. 2009 Nov;41(11):1234-7
references.pmid: 19838193
references.citation: Arthritis Rheum. 1997 Sep;40(9):1725
references.pmid: 9324032
references.citation: Arthritis Res Ther. 2008;10(5):R113
references.pmid: 18803832
references.citation: Ann Rheum Dis. 2010 May;69(5):883-6
references.pmid: 19717398
references.citation: PLoS Genet. 2008 May 30;4(5):e1000084
references.pmid: 18516230
references.citation: Mol Biol Rep. 2012 Sep;39(9):8861-6
references.pmid: 22729903
references.citation: Hum Immunol. 2011 Dec;72(12):1210-3
references.pmid: 21968398
references.citation: Ann Rheum Dis. 2010 Apr;69(4):625-6
references.pmid: 20237121
references.citation: Arthritis Rheum. 2008 Sep;58(9):2598-602
references.pmid: 18759272
references.citation: J Biol Chem. 2000 Jan 28;275(4):2693-7
references.pmid: 10644731
references.citation: Immunol Res. 2005;31(3):231-42
references.pmid: 15888914
references.citation: Arthritis Res Ther. 2010;12 Suppl 1:S5
references.pmid: 21303493
references.citation: Hum Immunol. 2011 Mar;72(3):249-55
references.pmid: 21167895
references.citation: J Immunol. 2008 Oct 1;181(7):5062-70
references.pmid: 18802110
references.citation: Genes Immun. 2009 Apr;10(3):219-26
references.pmid: 19225526
references.citation: Immunity. 2006 Sep;25(3):383-92
references.pmid: 16979570
references.citation: N Engl J Med. 2007 Sep 6;357(10):977-86
references.pmid: 17804842
references.citation: Lupus. 2004;13(4):217-22
references.pmid: 15176655
references.citation: Arthritis Rheum. 2008 Jul;58(7):1940-6
references.pmid: 18576330
references.citation: Genes Immun. 2009 Jul;10(5):373-9
references.pmid: 19440199
references.citation: Mod Rheumatol. 2010 Jun;20(3):257-62
references.pmid: 20169389
references.citation: Lupus. 2010 Oct;19(12):1374-83
references.pmid: 20947545
references.citation: PLoS Genet. 2010 Feb 12;6(2):e1000841
references.pmid: 20169177
references.citation: Mol Med. 2007 Sep-Oct;13(9-10):455-60
references.pmid: 17932559
references.citation: Nat Rev Genet. 2009 May;10(5):285-90
references.pmid: 19337289
references.citation: Ann Rheum Dis. 1994 Oct;53(10):675-80
references.pmid: 7979581
references.citation: Curr Opin Rheumatol. 2010 Mar;22(2):119-25
references.pmid: 20035223
references.citation: Chin Med J (Engl). 2010 Nov;123(22):3173-7
references.pmid: 21163111
references.citation: Genes Immun. 2007 Sep;8(6):445-55
references.pmid: 17581625