title: Tentative evidence for striatal hyperactivity in adolescent cannabis-using boys: a cross-sectional multicenter fMRI study.
abstract: Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences.
authors.affiliation: Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
authors.forename: Gerry
authors.initials: G
authors.lastname: Jager
authors.forename: Robert I
authors.initials: RI
authors.lastname: Block
authors.forename: Maartje
authors.initials: M
authors.lastname: Luijten
authors.forename: Nick F
authors.initials: NF
authors.lastname: Ramsey
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D000367:Age Factors; D001479:Basal Ganglia / Q000503:physiopathology*; D016739:Behavior, Addictive; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003463:Cues; D006801:Humans; D007484:Iowa; D008279:Magnetic Resonance Imaging; D008297:Male; D002189:Marijuana Abuse / Q000503:physiopathology* / Q000523:psychology; D008385:Marijuana Smoking / Q000503:physiopathology* / Q000523:psychology; D009042:Motivation; D009426:Netherlands; D011930:Reaction Time; D012737:Sex Factors; D013647:Task Performance and Analysis; D014040:Token Economy; D055815:Young Adult
references.citation: J Am Acad Child Adolesc Psychiatry. 2010 Jun;49(6):561-72, 572.e1-3
references.pmid: 20494266
references.citation: Neuroreport. 1993 Feb;4(2):135-8
references.pmid: 8453049
references.citation: Eur Neuropsychopharmacol. 2010 Mar;20(3):153-63
references.pmid: 20061126
references.citation: Ann N Y Acad Sci. 2008 Mar;1124:111-26
references.pmid: 18400927
references.citation: Behav Pharmacol. 2009 Feb;20(1):1-17
references.pmid: 19179847
references.citation: Addict Behav. 2007 May;32(5):977-90
references.pmid: 16930850
references.citation: Neuropsychopharmacology. 2002 Apr;26(4):520-9
references.pmid: 11927176
references.citation: Mol Cell Endocrinol. 2006 Jul 25;254-255:154-62
references.pmid: 16765510
references.citation: J Neurosci. 2012 Jul 18;32(29):10093-100
references.pmid: 22815523
references.citation: J Neurophysiol. 2006 Feb;95(2):948-59
references.pmid: 16192338
references.citation: Neuroimage. 2010 Jan 1;49(1):1133-43
references.pmid: 19631753
references.citation: J Am Acad Child Adolesc Psychiatry. 2000 Jan;39(1):28-38
references.pmid: 10638065
references.citation: Trends Neurosci. 2000 Jan;23(1):14-20
references.pmid: 10631784
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: J Neurosci. 2004 Feb 25;24(8):1793-802
references.pmid: 14985419
references.citation: J Anal Toxicol. 2008 Oct;32(8):562-9
references.pmid: 19007504
references.citation: Curr Drug Abuse Rev. 2008 Jun;1(2):114-23
references.pmid: 19630711
references.citation: Pharmacol Biochem Behav. 2009 Sep;93(3):212-21
references.pmid: 19593842
references.citation: Am J Psychiatry. 2011 May;168(5):540-9
references.pmid: 21362742
references.citation: Curr Pharm Des. 2012;18(1):113-8
references.pmid: 22236117
references.citation: Psychol Med. 2006 Mar;36(3):299-312
references.pmid: 16472412
references.citation: Child Neuropsychol. 2005 Oct;11(5):471-5
references.pmid: 16306021
references.citation: Neuroimage. 2006 Oct 1;32(4):1656-68
references.pmid: 16875843
references.citation: J Abnorm Psychol. 2009 Feb;118(1):203-13
references.pmid: 19222326
references.citation: J Neurosci. 2001 Aug 15;21(16):RC159
references.pmid: 11459880
references.citation: Neurosci Lett. 2006 Sep 25;405(3):196-201
references.pmid: 16901644