title: Effects of aerobic conditioning on cardiovascular sympathetic response to and recovery from challenge.
abstract: Exercise has widely documented cardioprotective effects, but the mechanisms behind these effects are still poorly understood. Here, we test the hypothesis that aerobic training lowers cardiovascular sympathetic responses to and speeds recovery from challenge. We conducted a randomized, controlled trial contrasting aerobic versus strength training on indices of cardiac (pre-ejection period, PEP) and vascular (low-frequency blood pressure variability, LF-BPV) sympathetic responses to and recovery from psychological and orthostatic challenge in 149 young, healthy, sedentary adults. Aerobic and strength training did not alter PEP or LF-BPV reactivity to or recovery from challenge. These findings, from a large randomized, controlled trial using an intent-to-treat design, show that moderate aerobic exercise training has no effect on PEP and LF-BPV reactivity to or recovery from psychological or orthostatic challenge. In healthy young adults, the cardioprotective effects of exercise training are unlikely to be mediated by changes in sympathetic activity.
authors.affiliation: Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Lindgren
authors.affiliation: Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Alex
authors.affiliation: Department of Psychiatry, Columbia University Medical Center, New York, New York, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Shapiro
authors.affiliation: Department of Psychiatry, Columbia University Medical Center, New York, New York, USA.|New York State Psychiatric Institute, New York, New York, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: McKinley
authors.affiliation: St. John's University, Jamaica, New York, USA.
authors.forename: E N
authors.initials: EN
authors.lastname: Brondolo
authors.affiliation: Department of Psychiatry, Columbia University Medical Center, New York, New York, USA.|New York State Psychiatric Institute, New York, New York, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Myers
authors.affiliation: New York State Psychiatric Institute, New York, New York, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Choi
authors.affiliation: Mailman School of Public Health, Columbia University, New York, New York, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lopez-Pintado
authors.affiliation: Department of Psychiatry, Columbia University Medical Center, New York, New York, USA.|New York State Psychiatric Institute, New York, New York, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Sloan
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002307:Cardiography, Impedance; D002319:Cardiovascular System; D004562:Electrocardiography; D015444:Exercise; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D064797:Physical Conditioning, Human / Q000379:methods*; D055070:Resistance Training / Q000379:methods*; D013312:Stress, Physiological / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000502:physiology*
keywords: Aerobic training; Normal subjects; Sympathetic nervous system reactivity and recovery
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