title: Combinatorial synthesis of pyrrolo[3,2-f]quinoline and pyrrolo[3,2-a]acridine derivatives via a three-component reaction under catalyst-free conditions.
abstract: A combinatorial synthesis of pyrrolo[3,2-f]quinoline and pyrrolo[3,2-a]acridine derivatives is described as a three-component reaction of aromatic aldehyde, 1H-indol-5-amine, and 1,3-dicarbonyl compounds under catalyst-free conditions. The 1,3-dicarbonyl compounds include 5,5-dimethylcyclohexane-1,3-dione, cyclopentane-1,3-dione, and 2H-indene-1,3-dione. It is interesting that the designed reactions gave aromatized or unaromatized products, which depend on the reaction temperature and reactants of 1,3-dicarbonyl compounds.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou Jiangsu 221116, P. R. China.
authors.forename: Yu-Jing
authors.initials: YJ
authors.lastname: Zhou
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Chen
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiang-Shan
authors.initials: XS
authors.lastname: Wang
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000166:Acridines; D000447:Aldehydes; D007211:Indoles; D007659:Ketones; D011758:Pyrroles; D011804:Quinolines; C579451:pyrrolo(2,3-f)quinoline