title: Genetics of ankylosing spondylitis.
abstract: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that affects the spine and sacroiliac joints. It causes significant disability and is associated with a number of other features including peripheral arthritis, anterior uveitis, psoriasis and inflammatory bowel disease (IBD). Significant progress has been made in the genetics of AS have in the last five years, leading to new treatments in trial, and major leaps in understanding of the aetiopathogenesis of the disease.
authors.affiliation: University of Queensland Diamantina Institute, Translational Research Institute, 37 Kent Road, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Robinson
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Brown
mesh_terms: D000626:Aminopeptidases / Q000235:genetics; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000235:genetics* / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications; D053759:Interleukin-23 / Q000235:genetics; D008285:Major Histocompatibility Complex / Q000235:genetics; D015778:Minor Histocompatibility Antigens; D011565:Psoriasis / Q000150:complications; D012446:Sacroiliac Joint / Q000473:pathology; D013131:Spine / Q000473:pathology; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000473:pathology*; D014606:Uveitis, Anterior / Q000150:complications
chemical_list: D015796:HLA-B27 Antigen; D053759:Interleukin-23; D015778:Minor Histocompatibility Antigens; D000626:Aminopeptidases; C464841:ERAP1 protein, human
keywords: Ankylosing spondylitis; Single nucleotide polymorphism association; Spondyloarthritis