title: Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation.
abstract: OBJECTIVE
  Age-related metabolic diseases are often associated with low-grade inflammation. The aim of the present study was to investigate the role of the transcriptional co-activator PGC-1α in the potential beneficial effects of exercise training and/or resveratrol in the prevention of age-associated low-grade inflammation. To address this, a long-term voluntary exercise training and resveratrol supplementation study was conducted.
  
  
  METHODS
  Three month old whole body PGC-1α KO and WT mice were randomly assigned to four groups: untrained chow-fed, untrained chow-fed supplemented with resveratrol, chow-fed voluntarily exercise trained and chow-fed supplemented with resveratrol and voluntarily exercise trained. The intervention lasted 12 months and three month old untrained chow-fed mice served as young controls.
  
  
  RESULTS
  Voluntary exercise training prevented an age-associated increase (p<0.05) in systemic IL-6 and adiposity in WT mice. PGC-1α expression was required for a training-induced prevention of an age-associated increase (p<0.05) in skeletal muscle TNFα protein. Independently of PGC-1α, both exercise training and resveratrol prevented an age-associated increase (p<0.05) in skeletal muscle protein carbonylation.
  
  
  CONCLUSIONS
  The present findings highlight that exercise training is a more effective intervention than resveratrol supplementation in reducing age-associated inflammation and that PGC-1α in part is required for the exercise training-induced anti-inflammatory effects.
authors.affiliation: Centre of Inflammation and Metabolism, August Krogh Centre, August Krogh Building, Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: jolesen@bio.ku.dk.
authors.forename: Jesper
authors.initials: J
authors.lastname: Olesen
authors.forename: Stine
authors.initials: S
authors.lastname: Ringholm
authors.forename: Maja M
authors.initials: MM
authors.lastname: Nielsen
authors.forename: Christina T
authors.initials: CT
authors.lastname: Brandt
authors.forename: Jesper T
authors.initials: JT
authors.lastname: Pedersen
authors.forename: Jens F
authors.initials: JF
authors.lastname: Halling
authors.forename: Laurie J
authors.initials: LJ
authors.lastname: Goodyear
authors.forename: Henriette
authors.initials: H
authors.lastname: Pilegaard
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005260:Female; D007249:Inflammation / Q000473:pathology / Q000517:prevention & control*; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010805:Physical Conditioning, Animal / Q000502:physiology*; D050050:Protein Carbonylation / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015850:Interleukin-6; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D012333:RNA, Messenger; D013267:Stilbenes; D014157:Transcription Factors; D014409:Tumor Necrosis Factor-alpha; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D000077185:Resveratrol
keywords: Aging; Exercise training; Low-grade inflammation; PGC-1α; Resveratrol
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