title: A case of severe thallium poisoning successfully treated with hemoperfusion and continuous veno-venous hemofiltration.
abstract: Thallium poisoning is a rare condition that is often misdiagnosed, delaying appropriate treatment. Left untreated, thallium toxicity can permanently damage the nervous and digestive systems or, in severe cases, lead to paralysis and death. It is most often treated by an oral administration of Prussian blue. Thallium has a long physiological half-life, and Prussian blue cannot sequester thallium outside the digestive tract. Therefore, the first priority in treating severe thallium poisoning is to lower blood levels as soon as possible. We report the case of a patient with supralethal blood levels of thallium treated successfully using combined hemoperfusion (HP) and continuous veno-venous hemofiltration (CVVH). Three rounds of HP alone decreased blood thallium levels by 20.2%, 34.8%, and 32.2%, while each of the five subsequent rounds of CVVH reduced thallium blood levels by 63.5%, 64.2%, 42.1%, 18.6%, and 22.6%. The reversal of symptoms and prevention of lasting neurological damage indicates that HP, CVVH, 2,3-dimercaptopropane-1-sulfonate, neuroprotective agents along with supportive therapy were used successfully to treat a case of severe thallium poisoning.
authors.affiliation: 1Department of Emergency, 307 Hospital of PLA, Beijing, China.
authors.forename: C
authors.initials: C
authors.lastname: Huang
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Tian
mesh_terms: D000328:Adult; D006440:Hemofiltration / Q000379:methods*; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D011041:Poisoning / Q000628:therapy; D013793:Thallium / Q000097:blood / Q000506:poisoning*; D016896:Treatment Outcome
chemical_list: D013793:Thallium
keywords: Thallium poisoning; continuous veno-venous hemofiltration; hemoperfusion