title: Effect of Bridging Anions on the Structure and Stability of Phenoxide Bridged Zinc Dipicolylamine Coordination Complexes.
abstract: A series of four related phenol derivatives, with 2,2'-dipicolylamine substituents at the ortho positions, were prepared and their Zn2+coordination complexes studied by spectroscopic methods. X-ray crystal diffraction analysis of a dinuclear zinc complex with two bridging acetate anions showed a ternary structure with highly charged interior and lipophilic exterior, which helps explain why this class of water-soluble complexes can effectively diffuse through cell membranes. The stability of the dinuclear zinc complexes in aqueous solution was found to be strongly anion dependent; that is, bridging oxyanions, such as acetate and pyrophosphate, lock the two Zn2+cations to the surrounding ligand and greatly enhance ligand/zinc affinity. Overall, the results provide new insight into the structural and mechanistic factors that control the recognition and chemosensing performance of phenoxide bridged dipicolylamine molecular probes.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, 2365 Nieuwland Science Hall, Notre Dame, IN 46556.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: O'Neil
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Bradley D
authors.initials: BD
authors.lastname: Smith
keywords: Anion recognition; X-ray crystallography; nuclear magnetic resonance; spectroscopic analysis; titration; zinc coordination
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