title: Human parvovirus B19 associated dilated cardiomyopathy.
abstract: We describe two children presenting with acute left ventricular dysfunction. Both cases had evidence of dilated cardiomyopathy, requiring inotropic support and were tested for cardiotropic viruses by conventional or real-time polymerase chain reaction using specific primers for enteroviruses, human parvovirus B19, Adenoviruses, Epstein-Barr virus (EBV), herpes simplex viruses 1 and 2 (HSV), human herpes virus-6 (HHV-6) and cytomegalovirus (CMV). IgG and IgM antibodies against parvovirus B19, EBV, HSV and CMV were also tested by ELISA. One case tested positive for parvovirus B19 infection and recovered completely within 6 months in absence of any specific therapy. The other case tested positive for parvovirus B19 infection in association with hypocalcaemia and was cured following standard heart failure therapy along with calcium and vitamin D supplementation. Sequence analysis of DNA products from both patients revealed genotype 3. To best of our knowledge this is first report of circulating genotype 3 from India.
authors.affiliation: Department of Microbiology, KG Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Parul
authors.initials: P
authors.lastname: Jain
authors.forename: Amita
authors.initials: A
authors.lastname: Jain
authors.forename: Danish Nasar
authors.initials: DN
authors.lastname: Khan
authors.forename: Mala
authors.initials: M
authors.lastname: Kumar
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000821:virology*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human
references.citation: Autoimmun Rev. 2004 Nov;3(7-8):476-86
references.pmid: 15546794
references.citation: J Med Virol. 2011 Oct;83(10):1818-25
references.pmid: 21837800
references.citation: Indian Pediatr. 2010 Sep;47(9):781-3
references.pmid: 21048260
references.citation: J Med Virol. 2008 Jul;80(7):1243-51
references.pmid: 18461615
references.citation: Hum Pathol. 2003 Jul;34(7):725-8
references.pmid: 12874772
references.citation: N Engl J Med. 2010 Apr 1;362(13):1248-9
references.pmid: 20357294
references.citation: Antivir Ther. 2010;15(2):193-201
references.pmid: 20386074
references.citation: Case Rep Cardiol. 2012;2012:180871
references.pmid: 24826236
references.citation: Clin Infect Dis. 1998 Feb;26(2):355-8
references.pmid: 9502455