title: The clinical profile of Kawasaki disease of children from three Polish centers: a retrospective study.
abstract: Kawasaki disease (KD) is one of the most common vasculitides of childhood. The aim of this retrospective study is to determine the incidence of KD and to evaluate its presenting symptoms, clinical course, laboratory tests, and treatment in patients with complete KD and incomplete KD at three pediatric rheumatology centers in Poland from January 2011 to December 2012. A total of 27 Caucasian children (12 boys and 15 girls) with median age of 3 years (range 4 months-12 years) were included in this study. The incidence of complete versus incomplete KD was 17 (63 %) versus 10 (37 %) children, respectively. Patients with incomplete KD significantly less presented cervical lymphadenopathy (20 vs. 88.2 %; p = 0.00075), changes in extremities (30 vs. 76.5 %; p = 0.04), and bilateral nonpurulent conjunctivitis (60 vs. 100 %; p = 0.01). Cardiac assessments show that the majority of patients with KD have not got coronary artery aneurysms (CAA). The median time from the onset of symptoms to intravenous immunoglobulin (IVIG) infusion was 7 days for complete KD and 11 days for incomplete KD. IVIG delay in the incomplete KD had no effect on the incidence of CAA. In conclusion, there were no differences in demographic features, age of onset, and laboratory tests of patients with complete and incomplete KD. Patients with incomplete KD significantly rarely presented cervical lymphadenopathy, changes in extremities, and conjunctival injection. Electrocardiography is a sensitive test to recognize cardiac involvement in the acute phase of KD. Despite the fact that incomplete forms of presentation often delay diagnosis, in most patients treatment with IVIG can avoid complication of CAA.
authors.affiliation: 3rd Department and Clinic of Paediatrics, Immunology and Rheumatology of Developmental Age, Wroclaw Medical University, ul. Koszarowa 5, 51-149, Wrocław, Poland, daiva.gorczyca@am.wroc.pl.
authors.forename: Daiva
authors.initials: D
authors.lastname: Gorczyca
authors.forename: Jacek
authors.initials: J
authors.lastname: Postępski
authors.forename: Edyta
authors.initials: E
authors.lastname: Olesińska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Lubieniecka
authors.forename: Iwona
authors.initials: I
authors.lastname: Lachór-Motyka
authors.forename: Violetta
authors.initials: V
authors.lastname: Opoka-Winiarska
authors.forename: Anna
authors.initials: A
authors.lastname: Gruenpeter
mesh_terms: D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003231:Conjunctivitis / Q000453:epidemiology; D003323:Coronary Aneurysm / Q000453:epidemiology; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D015994:Incidence; D007223:Infant; D008206:Lymphatic Diseases / Q000453:epidemiology; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D061665:Time-to-Treatment
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors
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