title: Reproducibility of blood pressure responses to dietary sodium and potassium interventions: the GenSalt study.
abstract: Blood pressure responses to dietary sodium and potassium interventions vary among individuals. We studied the long-term reproducibility of blood pressure responses to dietary sodium and potassium intake. We repeated the dietary sodium and potassium interventions among 487 Chinese adults 4.5 years after the original dietary intervention. The identical dietary intervention protocol, which included a 7-day low-sodium feeding (51.3 mmol/d), a 7-day high-sodium feeding (307.8 mmol/d), and a 7-day high-sodium feeding with oral potassium supplementation (60.0 mmol/d), was applied in both the initial and repeated studies. Three blood pressure measurements were obtained during each of the 3 days of baseline observation and on days 5, 6, and 7 of each intervention period. The results from the 24-hour urinary excretion of sodium and potassium showed excellent compliance with the study diet. Blood pressure responses to dietary intervention in the original and repeated studies were highly correlated. For example, the correlation coefficients (95% confidence interval) for systolic blood pressure levels were 0.77 (0.73-0.80) at baseline, 0.79 (0.75-0.82) during low sodium, 0.80 (0.77-0.83) during high sodium, and 0.82 (0.79-0.85) during high sodium and potassium supplementation interventions (all P<0.0001). The correlation coefficients for systolic blood pressure changes were 0.37 (0.29-0.44) from baseline to low sodium, 0.37 (0.29-0.44) from low to high sodium, and 0.28 (0.20-0.36) from high sodium to high sodium plus potassium supplementation (all P<0.0001). These data indicate that blood pressure responses to dietary sodium and potassium interventions have long-term reproducibility and stable characteristics in the general population.
authors.affiliation: Department of Population Genetics and Prevention, Fu Wai Hospital and Cardiovascular Institute, Beijing, China.
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Chen
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Huang
authors.forename: Lydia A
authors.initials: LA
authors.lastname: Bazzano
authors.forename: Fanghong
authors.initials: F
authors.lastname: Lu
authors.forename: Jianjun
authors.initials: J
authors.lastname: Mu
authors.forename: Jianxin
authors.initials: J
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.forename: Katherine
authors.initials: K
authors.lastname: Mills
authors.forename: Chung-Shiuan
authors.initials: CS
authors.lastname: Chen
authors.forename: Treva
authors.initials: T
authors.lastname: Rice
authors.forename: L Lee
authors.initials: LL
authors.lastname: Hamm
authors.forename: Jiang
authors.initials: J
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000503:physiopathology / Q000652:urine; D008875:Middle Aged; D017419:Potassium, Dietary / Q000008:administration & dosage* / Q000652:urine; D012982:Sodium, Dietary / Q000008:administration & dosage* / Q000652:urine
chemical_list: D017419:Potassium, Dietary; D012982:Sodium, Dietary
keywords: blood pressure; potassium, dietary; reproducibility of results; sodium, dietary
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