title: Free radicals and acute pancreatitis: much ado about … something.
abstract: There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic damage. Oxidative stress is also involved in the progression of the disease from a local damage to a systemic organ failure. However, therapeutic use of antioxidants failed to clearly show a clinical benefit in different trials. Therefore, although antioxidants alone seem to be not enough for the treatment of severe acute pancreatitis, future combined therapeutic strategies should include antioxidants in its composition.
authors.affiliation: Department of Experimental Pathology, IIBB-CSIC-IDIBAPS, CIBEREHD , Barcelona , Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Closa
mesh_terms: D000208:Acute Disease; D000818:Animals; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D018384:Oxidative Stress / Q000502:physiology; D010195:Pancreatitis / Q000188:drug therapy / Q000378:metabolism*; D019283:Pancreatitis, Acute Necrotizing / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D005609:Free Radicals; D017382:Reactive Oxygen Species