title: Chiral α-amino phosphonates via rhodium-catalyzed asymmetric 1,4-addition reactions.
abstract: A new approach for the preparation of enantioenriched α-amino phosphonates and derivatives is described. Indeed, the rhodium-catalyzed asymmetric 1,4-addition of potassium organotrifluoroborates to dehydroaminophosphonates afforded α-amino phosphonates in good yields and high enantioselectivities (up to 96%) using Difluorphos as a chiral ligand.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Paris, Laboratoire Charles Friedel (UMR 7223, CNRS), 11 rue Pierre et Marie Curie, 75231 Paris cedex 05, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lefevre
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Brayer
authors.forename: Benoît
authors.initials: B
authors.lastname: Folléas
authors.forename: Sylvain
authors.initials: S
authors.lastname: Darses
mesh_terms: D001881:Borates / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001881:Borates; D008024:Ligands; D063065:Organophosphonates; D012238:Rhodium