title: Prevalence of celiac disease in omani children with type 1 diabetes mellitus: a cross sectional study.
abstract: OBJECTIVE
  Published studies on the prevalence of celiac disease in type 1 diabetes mellitus from the Arab World are scant. We aim to report the prevalence of celiac disease in Omani children with type 1 diabetes mellitus.
  
  
  METHODS
  Children with type 1 diabetes mellitus were prospectively screened for celiac disease, at Sultan Qaboos University Hospital, Muscat, Oman over a period of one year (June 2011 - May 2012). Serum anti tissue transglutaminase IgA, endomysial IgA antibodies and total IgA were measured for screening of celiac disease. Children with positive anti-tissue transglutaminase and/or endomysial IgA antibodies underwent endoscopy.
  
  
  RESULTS
  A total of 103 children with type 1 diabetes mellitus were initially included. Ten patients were lost to follow up. Ninety-three patients aged 2-17 years underwent screening for celiac disease. Sixteen patients had positive anti-tissue transglutaminase (17%). Fourteen patients underwent endoscopy with duodenal biopsies, while two were lost to follow-up. Five patients with positive anti-tissue transglutaminase had intestinal biopsy proven celiac disease. The prevalence of celiac disease is 5.5% in our cohort of children and adolescents with type 1 diabetes mellitus.
  
  
  CONCLUSIONS
  The prevalence of celiac disease in Omani children and adolescents with type 1 diabetes mellitus is similar to the World's reported prevalence, but is less than that reported for Middle Eastern Arab children. To our knowledge, this is the first reported study on the prevalence of celiac disease in Omani children with type 1 diabetes mellitus.
authors.affiliation: Gastroenterology Unit, Department of Child Health, Sultan Qaboos University Hospital, Muscat, PC 123, Sultanate of Oman.
authors.forename: Siham
authors.initials: S
authors.lastname: Al-Sinani
authors.forename: Sharef Waadallah
authors.initials: SW
authors.lastname: Sharef
authors.forename: Saif
authors.initials: S
authors.lastname: Al-Yaarubi
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Al-Zakwani
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Naamani
authors.forename: Aisha
authors.initials: A
authors.lastname: Al-Hajri
authors.forename: Said
authors.initials: S
authors.lastname: Al-Hasani
keywords: Anti-tissue transglutaminase; Celiac Disease; Oman; Type 1 Diabetes Mellitus
references.citation: World J Gastroenterol. 2009 Oct 14;15(38):4775-80
references.pmid: 19824110
references.citation: Diabetes Metab Res Rev. 2003 Jan-Feb;19(1):69-75
references.pmid: 12592646
references.citation: Lancet. 1997 Jun 14;349(9067):1755-9
references.pmid: 9193393
references.citation: J Pediatr Gastroenterol Nutr. 2001 Oct;33(4):462-5
references.pmid: 11698764
references.citation: J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):136-60
references.pmid: 22197856
references.citation: Dig Liver Dis. 2004 Mar;36(3):191-4
references.pmid: 15046188
references.citation: Evid Rep Technol Assess (Summ). 2004 Jun;(104):1-6
references.pmid: 15346868
references.citation: Saudi Med J. 2003 Oct;24(10):1113-5
references.pmid: 14578980
references.citation: Gastroenterol Clin Biol. 2007 May;31(5):462-6
references.pmid: 17541335
references.citation: J Pediatr Gastroenterol Nutr. 2009 May;48(5):544-9
references.pmid: 19367177
references.citation: Can J Gastroenterol. 2001 May;15(5):297-301
references.pmid: 11381296
references.citation: Pediatr Diabetes. 2008 Aug;9(4 Pt 2):354-9
references.pmid: 18774995
references.citation: Saudi Med J. 2003 Jul;24(7):791
references.pmid: 12883621
references.citation: J Pediatr Gastroenterol Nutr. 2010 Feb;50(2):140-6
references.pmid: 19841593
references.citation: Pediatrics. 2001 Jan;107(1):E8
references.pmid: 11134472
references.citation: Diabetes Care. 2004 Jun;27(6):1294-8
references.pmid: 15161778
references.citation: Acta Paediatr. 2001 Nov;90(11):1238-43
references.pmid: 11808892
references.citation: Niger Postgrad Med J. 2006 Mar;13(1):53-6
references.pmid: 16633380
references.citation: Gut. 1989 Mar;30(3):333-8
references.pmid: 2707633
references.citation: Diabetologia. 2000 Aug;43(8):1005-11
references.pmid: 10990078
references.citation: BMC Gastroenterol. 2012 Dec 23;12:180
references.pmid: 23259699
references.citation: Saudi Med J. 2012 May;33(5):541-6
references.pmid: 22588816
references.citation: Eur J Gastroenterol Hepatol. 1999 Oct;11(10):1185-94
references.pmid: 10524652
references.citation: Oman Med J. 2013 Jan;28(1):70-2
references.pmid: 23386952
references.citation: Indian Pediatr. 2010 Mar;47(3):268-70
references.pmid: 19430065
references.citation: Acta Paediatr Suppl. 1996 May;412:58-60
references.pmid: 8783762