title: Bile formation and secretion.
abstract: Bile is a unique and vital aqueous secretion of the liver that is formed by the hepatocyte and modified down stream by absorptive and secretory properties of the bile duct epithelium. Approximately 5% of bile consists of organic and inorganic solutes of considerable complexity. The bile-secretory unit consists of a canalicular network which is formed by the apical membrane of adjacent hepatocytes and sealed by tight junctions. The bile canaliculi (∼1 μm in diameter) conduct the flow of bile countercurrent to the direction of portal blood flow and connect with the canal of Hering and bile ducts which progressively increase in diameter and complexity prior to the entry of bile into the gallbladder, common bile duct, and intestine. Canalicular bile secretion is determined by both bile salt-dependent and independent transport systems which are localized at the apical membrane of the hepatocyte and largely consist of a series of adenosine triphosphate-binding cassette transport proteins that function as export pumps for bile salts and other organic solutes. These transporters create osmotic gradients within the bile canalicular lumen that provide the driving force for movement of fluid into the lumen via aquaporins. Species vary with respect to the relative amounts of bile salt-dependent and independent canalicular flow and cholangiocyte secretion which is highly regulated by hormones, second messengers, and signal transduction pathways. Most determinants of bile secretion are now characterized at the molecular level in animal models and in man. Genetic mutations serve to illuminate many of their functions.
authors.affiliation: Department of Medicine and Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA. james.boyer@yale.edu
authors.forename: James L
authors.initials: JL
authors.lastname: Boyer
mesh_terms: D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D001652:Bile Ducts / Q000166:cytology / Q000378:metabolism; D001692:Biological Transport / Q000502:physiology; D005762:Gastroenterology / Q000266:history; D022781:Hepatocytes / Q000378:metabolism / Q000648:ultrastructure; D049673:History, 20th Century; D006801:Humans; D008099:Liver / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D001647:Bile Acids and Salts; D026901:Membrane Transport Proteins
references.citation: Antioxid Redox Signal. 2003 Aug;5(4):449-56
references.pmid: 13678533
references.citation: Semin Liver Dis. 2000;20(3):339-51
references.pmid: 11076400
references.citation: Am J Physiol. 1997 May;272(5 Pt 1):G1064-74
references.pmid: 9176215
references.citation: Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G126-35
references.pmid: 20395535
references.citation: Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G667-74
references.pmid: 20203059
references.citation: Am J Physiol Renal Physiol. 2005 Feb;288(2):F327-33
references.pmid: 15454390
references.citation: Am J Physiol. 1993 Mar;264(3 Pt 1):G528-34
references.pmid: 8460705
references.citation: Vitam Horm. 1968;26:1-63
references.pmid: 4890102
references.citation: Biol Trace Elem Res. 1996 Oct-Nov;55(1-2):181-9
references.pmid: 8971365
references.citation: Pflugers Arch. 2007 Feb;453(5):643-59
references.pmid: 16847695
references.citation: Biochem Biophys Res Commun. 2004 Oct 1;322(4):1318-25
references.pmid: 15336978
references.citation: J Hepatol. 1996 Mar;24(3):335-42
references.pmid: 8778202
references.citation: Hepatology. 1997 Jul;26(1):155-64
references.pmid: 9214465
references.citation: Mol Pharm. 2009 Nov-Dec;6(6):1644-61
references.pmid: 19558188
references.citation: J Cell Biol. 1999 May 31;145(5):1089-102
references.pmid: 10352024
references.citation: J Clin Invest. 2007 May;117(5):1422-31
references.pmid: 17476361
references.citation: Gut. 2009 Apr;58(4):537-44
references.pmid: 18987030
references.citation: Hepatology. 2001 Jan;33(1):166-76
references.pmid: 11124833
references.citation: World J Gastroenterol. 2006 Jun 14;12(22):3553-63
references.pmid: 16773712
references.citation: Proc Natl Acad Sci U S A. 1984 Oct;81(20):6516-20
references.pmid: 6149546
references.citation: J Endocrinol. 2006 Mar;188(3):635-43
references.pmid: 16522742
references.citation: Am J Physiol. 1991 Sep;261(3 Pt 1):G512-22
references.pmid: 1887897
references.citation: Am J Physiol. 1999 Jan;276(1):G280-6
references.pmid: 9887005
references.citation: Vitam Horm. 2007;76:1-21
references.pmid: 17628169
references.citation: Hepatology. 2005 Sep;42(3):539-48
references.pmid: 16108046
references.citation: Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G58-67
references.pmid: 17947449
references.citation: J Cell Biol. 1992 Dec;119(5):1173-82
references.pmid: 1447295
references.citation: Hepatology. 1982 Nov-Dec;2(6):763-8
references.pmid: 7141386
references.citation: Biochem J. 1992 May 15;284 ( Pt 1):67-74
references.pmid: 1599411
references.citation: Am J Physiol. 1997 Oct;273(4):G849-53
references.pmid: 9357826
references.citation: Am J Physiol Cell Physiol. 2005 May;288(5):C1161-70
references.pmid: 15647389
references.citation: J Cell Sci. 2010 Oct 1;123(Pt 19):3294-302
references.pmid: 20826460
references.citation: Hepatology. 1992 Jan;15(1):107-16
references.pmid: 1727785
references.citation: Biochim Biophys Acta. 2003 Jan 10;1609(1):1-18
references.pmid: 12507753
references.citation: Hepatology. 2000 Dec;32(6):1317-28
references.pmid: 11093739
references.citation: J Cell Sci. 1998 Apr;111 ( Pt 8):1137-45
references.pmid: 9512509
references.citation: Proc Soc Exp Biol Med. 1958 Apr;97(4):780-4
references.pmid: 13554481
references.citation: Hepatology. 2010 Dec;52(6):2167-76
references.pmid: 21049545
references.citation: Am J Physiol. 1997 May;272(5 Pt 1):G1168-74
references.pmid: 9176227
references.citation: Mol Pharmacol. 2000 Aug;58(2):335-40
references.pmid: 10908301
references.citation: Pharm Res. 2007 Oct;24(10):1803-23
references.pmid: 17404808
references.citation: Hepatology. 2004 Jun;39(6):1739-45
references.pmid: 15185318
references.citation: Am J Physiol. 1993 Aug;265(2 Pt 1):G347-53
references.pmid: 8368316
references.citation: J Biol Chem. 2005 Mar 11;280(10):8742-7
references.pmid: 15611112
references.citation: Nat Genet. 1993 Dec;5(4):344-50
references.pmid: 8298641
references.citation: J Clin Invest. 2002 Oct;110(7):965-72
references.pmid: 12370274
references.citation: Nat Genet. 1998 Nov;20(3):233-8
references.pmid: 9806540
references.citation: Semin Liver Dis. 1996 May;16(2):129-36
references.pmid: 8781018
references.citation: J Cell Sci. 1996 Sep;109 ( Pt 9):2287-98
references.pmid: 8886979
references.citation: Hoppe Seylers Z Physiol Chem. 1978 Feb;359(2):181-92
references.pmid: 649053
references.citation: Hepatology. 2001 Aug;34(2):351-9
references.pmid: 11481620
references.citation: J Biol Chem. 2001 Apr 13;276(15):12147-52
references.pmid: 11278499
references.citation: J Lab Clin Med. 1968 Jul;72(1):169-76
references.pmid: 4968980
references.citation: Gastroenterology. 2007 Nov;133(5):1726-8
references.pmid: 17983816
references.citation: Lab Invest. 1978 Aug;39(2):110-9
references.pmid: 682596
references.citation: J Biol Chem. 2009 Apr 10;284(15):9947-54
references.pmid: 19228692
references.citation: J Biol Chem. 1984 Aug 25;259(16):10614-22
references.pmid: 6469975
references.citation: Cancer Res. 1995 May 15;55(10):2029-34
references.pmid: 7538046
references.citation: Gastroenterology. 1990 Jul;99(1):216-28
references.pmid: 2344927
references.citation: Proteomics. 2011 Dec;11(23):4443-53
references.pmid: 22114102
references.citation: J Clin Invest. 1994 Mar;93(3):1326-31
references.pmid: 8132774
references.citation: J Clin Invest. 1995 Jan;95(1):412-6
references.pmid: 7814642
references.citation: J Biol Chem. 1994 Jan 14;269(2):1340-7
references.pmid: 8288599
references.citation: J Mol Biol. 2001 Feb 9;306(1):37-46
references.pmid: 11178892
references.citation: Am J Physiol. 1990 Nov;259(5 Pt 1):G736-44
references.pmid: 2173415
references.citation: Biochem Biophys Res Commun. 2009 Nov 20;389(3):431-6
references.pmid: 19732748
references.citation: World J Gastroenterol. 2008 Nov 28;14(44):6786-801
references.pmid: 19058304
references.citation: Handb Exp Pharmacol. 2011;(201):373-402
references.pmid: 21103976
references.citation: Biochem J. 1994 Oct 1;303 ( Pt 1):33-6
references.pmid: 7945260
references.citation: Gastroenterology. 1988 Sep;95(3):793-804
references.pmid: 3396824
references.citation: J Clin Invest. 1993 Dec;92(6):2984-93
references.pmid: 8254052
references.citation: Wien Med Wochenschr. 2008;158(19-20):565-9
references.pmid: 18998074
references.citation: Pflugers Arch. 2007 Feb;453(5):745-52
references.pmid: 16440216
references.citation: Xenobiotica. 2008 Jul;38(7-8):1107-18
references.pmid: 18668441
references.citation: Proc Natl Acad Sci U S A. 1990 May;87(9):3557-61
references.pmid: 2333302
references.citation: J Biol Chem. 1983 Mar 25;258(6):3602-7
references.pmid: 6833218
references.citation: Br J Pharmacol. 2011 Dec;164(7):1817-25
references.pmid: 21457222
references.citation: Gastroenterology. 2001 Feb;120(2):525-33
references.pmid: 11159893
references.citation: Gastroenterology. 1981 May;80(5 pt 1):1037-41
references.pmid: 7202962
references.citation: J Biol Chem. 2004 Dec 24;279(52):54348-57
references.pmid: 15471871
references.citation: Dig Dis. 2011;29(1):45-7
references.pmid: 21691103
references.citation: Annu Rev Biochem. 2003;72:137-74
references.pmid: 12543708
references.citation: Science. 2002 Apr 5;296(5565):138-41
references.pmid: 11935026
references.citation: Gastroenterology. 1980 Jul;79(1):82-9
references.pmid: 7380227
references.citation: Am J Physiol. 1997 Aug;273(2 Pt 1):G303-13
references.pmid: 9277408
references.citation: Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G831-41
references.pmid: 15860642
references.citation: Dig Dis Sci. 1986 Apr;31(4):361-8
references.pmid: 3956332
references.citation: Mol Biol Cell. 2004 Jul;15(7):3485-96
references.pmid: 15121884
references.citation: Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):4-6
references.pmid: 12509503
references.citation: Biochem J. 1981 Apr 15;196(1):11-6
references.pmid: 7306064
references.citation: J Clin Invest. 2007 Jul;117(7):1968-78
references.pmid: 17571164
references.citation: Biochem J. 1999 Mar 1;338 ( Pt 2):393-401
references.pmid: 10024515
references.citation: Cell. 1994 May 20;77(4):491-502
references.pmid: 7910522
references.citation: Am J Physiol Gastrointest Liver Physiol. 2006 Mar;290(3):G476-85
references.pmid: 16269519
references.citation: Gastroenterology. 2008 Apr;134(4):1215-23
references.pmid: 18395099
references.citation: J Biol Chem. 2001 Mar 9;276(10):7218-24
references.pmid: 11113123
references.citation: Lab Invest. 2009 Apr;89(4):456-69
references.pmid: 19204666
references.citation: Hepatology. 2010 Jan;51(1):286-96
references.pmid: 19918981
references.citation: Gastroenterology. 1986 Apr;90(4):837-52
references.pmid: 3949115
references.citation: Arch Intern Med. 1972 Oct;130(4):533-41
references.pmid: 4562150
references.citation: Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9
references.pmid: 12835412
references.citation: Hepatology. 1997 Apr;25(4):976-85
references.pmid: 9096607
references.citation: Scand J Gastroenterol. 2006 Apr;41(4):445-50
references.pmid: 16635913
references.citation: J Lipid Res. 1990 Feb;31(2):289-98
references.pmid: 2324648
references.citation: J Hepatol. 2012 Sep;57(3):695-8
references.pmid: 22609309
references.citation: Hepatology. 2004 Mar;39(3):779-91
references.pmid: 14999697
references.citation: Arch Biochem Biophys. 1998 Feb 15;350(2):183-92
references.pmid: 9473291
references.citation: J Hepatol. 1996 May;24(5):631-44
references.pmid: 8773922
references.citation: Annu Rev Biochem. 1993;62:385-427
references.pmid: 8102521
references.citation: Gastroenterology. 2003 Mar;124(3):737-53
references.pmid: 12612912
references.citation: Semin Liver Dis. 2011 Aug;31(3):245-59
references.pmid: 21901655
references.citation: Am J Physiol. 1986 Dec;251(6 Pt 1):C872-82
references.pmid: 2431623
references.citation: J Biol Chem. 1997 Jun 13;272(24):15174-83
references.pmid: 9182539
references.citation: J Biol Chem. 2000 Mar 24;275(12):8835-43
references.pmid: 10722729
references.citation: Gastroenterology. 2004 Aug;127(2):379-84
references.pmid: 15300568
references.citation: Semin Liver Dis. 2000;20(3):373-84
references.pmid: 11076403
references.citation: Drug Metab Dispos. 2006 Sep;34(9):1582-99
references.pmid: 16763017
references.citation: J Hepatol. 2010 Jul;53(1):170-8
references.pmid: 20447715
references.citation: J Hepatol. 1996 Nov;25(5):725-32
references.pmid: 8938552
references.citation: Nat Genet. 2002 Jul;31(3):320-5
references.pmid: 12068294
references.citation: Hepatology. 2012 Feb;55(2):575-83
references.pmid: 21953282
references.citation: Annu Rev Physiol. 2002;64:635-61
references.pmid: 11826283
references.citation: Biochim Biophys Acta. 1999 Dec 6;1461(2):347-57
references.pmid: 10581366
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G612-25
references.pmid: 11518673
references.citation: Am J Physiol. 1989 Mar;256(3 Pt 1):G482-90
references.pmid: 2564253
references.citation: J Clin Invest. 1979 Jul;64(1):83-8
references.pmid: 447863
references.citation: Arch Biochem Biophys. 2012 Jan 15;517(2):123-30
references.pmid: 22093699
references.citation: Annu Rev Physiol. 1998;60:121-42
references.pmid: 9558457
references.citation: Gastroenterology. 1986 Nov;91(5):1278-88
references.pmid: 3758619
references.citation: Hepatology. 2002 Jun;35(6):1409-19
references.pmid: 12029626
references.citation: J Pharmacol Exp Ther. 2009 Apr;329(1):252-61
references.pmid: 19141712
references.citation: Am J Physiol Gastrointest Liver Physiol. 2011 Feb;300(2):G364-70
references.pmid: 21109590
references.citation: Gastroenterology. 2000 Oct;119(4):1113-22
references.pmid: 11040198
references.citation: J Biol Chem. 1986 Jun 15;261(17):7860-5
references.pmid: 2872220
references.citation: Annu Rev Pharmacol Toxicol. 2012;52:135-51
references.pmid: 21854228
references.citation: FASEB J. 1997 Jan;11(1):19-28
references.pmid: 9034162
references.citation: Am J Physiol. 1988 Jan;254(1 Pt 1):G1-7
references.pmid: 2892423
references.citation: J Exp Biol. 2009 Jun;212(Pt 11):1630-7
references.pmid: 19448073
references.citation: Science. 1981 May 29;212(4498):1041-2
references.pmid: 7015506
references.citation: Drug Metab Dispos. 2008 Aug;36(8):1616-23
references.pmid: 18490433
references.citation: Hepatology. 1997 May;25(5):1184-91
references.pmid: 9141437
references.citation: Hepatology. 1999 Feb;29(2):483-93
references.pmid: 9918926
references.citation: Gastroenterology. 1996 May;110(5):1636-43
references.pmid: 8613073
references.citation: Annu Rev Physiol. 2002;64:595-608
references.pmid: 11826281
references.citation: Mol Cell Endocrinol. 2013 Apr 10;368(1-2):59-70
references.pmid: 22579755
references.citation: Handb Exp Pharmacol. 2011;(201):205-59
references.pmid: 21103971
references.citation: Am J Physiol. 1992 Jun;262(6 Pt 1):G1027-32
references.pmid: 1377450
references.citation: Am J Physiol. 1995 Nov;269(5 Pt 1):G789-99
references.pmid: 7491972
references.citation: Gastroenterology. 1988 Aug;95(2):417-24
references.pmid: 3391369
references.citation: Gastroenterology. 1982 Mar;82(3):569-73
references.pmid: 7054049
references.citation: Science. 1996 Apr 12;272(5259):227-34
references.pmid: 8602507
references.citation: Drug Metab Rev. 1976;5(2):165-96
references.pmid: 802467
references.citation: J Biol Chem. 1994 Aug 5;269(31):19731-7
references.pmid: 8051053
references.citation: Lab Anim Sci. 1992 Feb;42(1):27-34
references.pmid: 1316504
references.citation: J Clin Invest. 2010 Aug;120(8):2942-52
references.pmid: 20644253
references.citation: Physiol Rev. 1980 Apr;60(2):303-26
references.pmid: 6247725
references.citation: J Biol Chem. 2010 May 28;285(22):16504-12
references.pmid: 20177056
references.citation: Biochem J. 2005 Nov 1;391(Pt 3):549-60
references.pmid: 15984932
references.citation: J Hepatol. 2006 Apr;44(4):768-75
references.pmid: 16225954
references.citation: Xenobiotica. 2008 Jul;38(7-8):778-801
references.pmid: 18668430
references.citation: J Biol Chem. 1998 Apr 17;273(16):10046-50
references.pmid: 9545351
references.citation: J Lipid Res. 1987 May;28(5):589-95
references.pmid: 3598401
references.citation: Am J Physiol. 1992 May;262(5 Pt 1):G806-12
references.pmid: 1590390
references.citation: Gastroenterology. 1999 May;116(5):1176-83
references.pmid: 10220510
references.citation: Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16237-42
references.pmid: 12444248
references.citation: J Pharm Sci. 1967 Jan;56(1):58-62
references.pmid: 6030496
references.citation: Am J Physiol. 1999 Dec;277(6):G1165-72
references.pmid: 10600813
references.citation: Dev Dyn. 2008 Aug;237(8):2007-12
references.pmid: 18407555
references.citation: Am J Physiol. 1984 Sep;247(3 Pt 1):G199-205
references.pmid: 6383073
references.citation: Hepatology. 1993 May;17(5):854-60
references.pmid: 8098315
references.citation: Hepatology. 1997 Jun;25(6):1539-42
references.pmid: 9185779
references.citation: Pharm Res. 2002 Jan;19(1):34-41
references.pmid: 11837698
references.citation: Curr Drug Metab. 2011 Feb;12(2):139-53
references.pmid: 21395542
references.citation: Gastroenterology. 1999 Aug;117(2):420-8
references.pmid: 10419925
references.citation: Nat Genet. 1998 Mar;18(3):219-24
references.pmid: 9500542
references.citation: World J Gastroenterol. 2008 Oct 7;14(37):5641-9
references.pmid: 18837079
references.citation: Biochem J. 2000 May 15;348 Pt 1:183-8
references.pmid: 10794730
references.citation: Pharmacogenet Genomics. 2007 Jan;17(1):47-60
references.pmid: 17264802
references.citation: Lab Invest. 1985 Sep;53(3):275-9
references.pmid: 4033067
references.citation: Nat Med. 1999 Sep;5(9):1048-51
references.pmid: 10470083
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G438-46
references.pmid: 11447024
references.citation: Am J Physiol. 1992 Nov;263(5 Pt 1):G617-24
references.pmid: 1443136
references.citation: Hepatology. 2002 Sep;36(3):641-51
references.pmid: 12198656
references.citation: Biochem Pharmacol. 2012 Jan 15;83(2):279-85
references.pmid: 22062654
references.citation: Expert Opin Drug Metab Toxicol. 2008 Jan;4(1):1-15
references.pmid: 18370855
references.citation: Biol Chem. 2010 Jul;391(7):785-9
references.pmid: 20623999
references.citation: J Biol Chem. 2005 Mar 11;280(10):9610-7
references.pmid: 15632119
references.citation: J Clin Invest. 1979 Jul;64(1):312-20
references.pmid: 109471
references.citation: Am J Physiol. 1993 Sep;265(3 Pt 1):G579-86
references.pmid: 8105696
references.citation: Am J Physiol. 1996 Feb;270(2 Pt 1):G246-52
references.pmid: 8779965
references.citation: Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1403-8
references.pmid: 21220320
references.citation: Am J Physiol. 1996 Jan;270(1 Pt 1):G1-5
references.pmid: 8772494
references.citation: Pflugers Arch. 2007 Feb;453(5):611-20
references.pmid: 17051391
references.citation: Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):511-6
references.pmid: 9892664
references.citation: Hepatology. 2006 Jul;44(1):195-204
references.pmid: 16799980
references.citation: J Hepatol. 2003 Jun;38(6):717-27
references.pmid: 12763363
references.citation: J Clin Invest. 1985 Apr;75(4):1256-63
references.pmid: 2985654
references.citation: Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):792-6
references.pmid: 8290601
references.citation: Gastroenterology. 2003 Apr;124(4):1037-42
references.pmid: 12671900
references.citation: Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10629-33
references.pmid: 1961729
references.citation: Biochim Biophys Acta. 2005 Jun 30;1741(1-2):11-24
references.pmid: 15919184
references.citation: Methods Enzymol. 1990;192:534-45
references.pmid: 1963666
references.citation: Hepatology. 2001 May;33(5):1206-16
references.pmid: 11343250
references.citation: Gastroenterology. 1999 Feb;116(2):401-10
references.pmid: 9922322
references.citation: Gastroenterology. 1993 Aug;105(2):554-71
references.pmid: 8335210
references.citation: J Biol Chem. 1999 Sep 10;274(37):26416-24
references.pmid: 10473600
references.citation: Biochem J. 1989 Feb 1;257(3):759-68
references.pmid: 2930484
references.citation: Hepatology. 1993 Feb;17(2):318-29
references.pmid: 8428731
references.citation: Hepatology. 2005 Dec;42(6):1270-9
references.pmid: 16317684
references.citation: Am J Physiol. 1976 Apr;230(4):974-81
references.pmid: 1267029
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9709-14
references.pmid: 19478059
references.citation: J Biol Chem. 1995 Jan 20;270(3):1074-81
references.pmid: 7836362
references.citation: FEBS Lett. 1994 Apr 25;343(2):168-72
references.pmid: 7909523
references.citation: Int J Biochem Cell Biol. 2004 Jan;36(1):39-77
references.pmid: 14592533
references.citation: Expert Rev Proteomics. 2009 Jun;6(3):285-301
references.pmid: 19489700
references.citation: J Lab Clin Med. 1983 Feb;101(2):317-26
references.pmid: 6822766
references.citation: Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7674-7
references.pmid: 1502182
references.citation: Am J Dis Child. 1969 Jan;117(1):112-24
references.pmid: 5762004
references.citation: Gut. 2002 Jul;51(1):113-9
references.pmid: 12077103
references.citation: Am J Physiol. 1992 Oct;263(4 Pt 1):G527-32
references.pmid: 1329554
references.citation: Mol Cell Proteomics. 2004 Jul;3(7):715-28
references.pmid: 15084671
references.citation: Hepatology. 1991 Oct;14(4 Pt 1):655-9
references.pmid: 1916666
references.citation: Gastroenterology. 1995 Mar;108(3):824-33
references.pmid: 7875485
references.citation: Hepatology. 2011 Nov;54(5):1790-9
references.pmid: 21748767
references.citation: Front Biosci (Landmark Ed). 2011 Jun 01;16:2642-52
references.pmid: 21622200
references.citation: Hepatology. 1995 Oct;22(4 Pt 1):1273-8
references.pmid: 7557881
references.citation: Biochem J. 2001 Aug 15;358(Pt 1):1-5
references.pmid: 11485545
references.citation: BMC Evol Biol. 2010 May 06;10:133
references.pmid: 20444292
references.citation: Biochem J. 1991 Sep 15;278 ( Pt 3):637-41
references.pmid: 1716882
references.citation: Hepatology. 2009 Apr;49(4):1218-27
references.pmid: 19185004
references.citation: Hepatology. 2004 May;39(5):1382-9
references.pmid: 15122767
references.citation: Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G179-G186
references.pmid: 18497332
references.citation: Hepatology. 2007 Jun;45(6):1506-16
references.pmid: 17538928
references.citation: Cell. 1996 Nov 1;87(3):507-17
references.pmid: 8898203
references.citation: Am J Physiol. 1998 Jan;274(1):G157-69
references.pmid: 9458785
references.citation: J Biol Chem. 2003 Sep 19;278(38):36688-98
references.pmid: 12837754
references.citation: Drug Resist Updat. 2006 Aug-Oct;9(4-5):227-46
references.pmid: 17092765
references.citation: Hepatology. 2009 Nov;50(5):1597-605
references.pmid: 19731236
references.citation: J Surg Res. 1975 Apr;18(4):391-7
references.pmid: 1142754
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 1974;285(2):165-74
references.pmid: 4281067
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 Feb;280(2):G247-54
references.pmid: 11208547
references.citation: J Clin Invest. 1993 Jan;91(1):319-28
references.pmid: 7678606
references.citation: Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6590-4
references.pmid: 1862084
references.citation: Am J Physiol. 1997 May;272(5 Pt 1):G1268-75
references.pmid: 9176239
references.citation: Pharmacol Rev. 1984 Mar;36(1):1-67
references.pmid: 6144113
references.citation: Nutr Rev. 1985 Aug;43(8):250-2
references.pmid: 3900824
references.citation: Pflugers Arch. 2004 Feb;447(5):653-65
references.pmid: 14579113
references.citation: J Pharmacol Exp Ther. 2006 May;317(2):778-85
references.pmid: 16436500
references.citation: J Cell Biol. 1991 Jun;113(5):1069-80
references.pmid: 2040644
references.citation: Gastroenterology. 2006 Aug;131(2):624-9
references.pmid: 16890614
references.citation: Am J Physiol. 1995 Jul;269(1 Pt 1):G110-8
references.pmid: 7631787
references.citation: Gastroenterology. 2004 Jul;127(1):261-74
references.pmid: 15236191
references.citation: N Engl J Med. 1998 Oct 22;339(17):1217-27
references.pmid: 9780343
references.citation: Semin Liver Dis. 2010 May;30(2):125-33
references.pmid: 20422495
references.citation: Gastroenterology. 1997 Jul;113(1):255-64
references.pmid: 9207286
references.citation: J Clin Invest. 1995 Aug;96(2):665-75
references.pmid: 7635959
references.citation: Cell. 2000 Sep 15;102(6):731-44
references.pmid: 11030617
references.citation: Cell. 1993 Nov 5;75(3):451-62
references.pmid: 8106172
references.citation: J Pharmacol Exp Ther. 2005 Aug;314(2):876-82
references.pmid: 15901796
references.citation: C R Biol. 2011 Feb;334(2):100-17
references.pmid: 21333941
references.citation: Hepatology. 2009 Feb;49(2):553-67
references.pmid: 19101985
references.citation: Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1252-8
references.pmid: 15650133
references.citation: J Cell Biol. 1987 May;104(5):1239-48
references.pmid: 3032985
references.citation: Am J Physiol Gastrointest Liver Physiol. 2004 Apr;286(4):G538-46
references.pmid: 14604861
references.citation: Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G937-47
references.pmid: 22345554
references.citation: Gastroenterology. 1995 Mar;108(3):841-9
references.pmid: 7875487
references.citation: Semin Cancer Biol. 1997 Jun;8(3):161-70
references.pmid: 9441946
references.citation: J Pathol. 2012 Jan;226(2):300-15
references.pmid: 21984474
references.citation: J Hepatol. 2003 Sep;39(3):447-52
references.pmid: 12927934
references.citation: Gastroenterology. 2002 Apr;122(4):1058-69
references.pmid: 11910357
references.citation: Hepatology. 2009 May;49(5):1673-82
references.pmid: 19197976
references.citation: Hepatology. 2007 Apr;45(4):1046-55
references.pmid: 17393504
references.citation: Gastroenterology. 2002 Nov;123(5):1659-66
references.pmid: 12404240
references.citation: Hepatology. 1983 Jul-Aug;3(4):614-7
references.pmid: 6345333
references.citation: Hepatology. 2005 May;41(5):1160-72
references.pmid: 15841457
references.citation: Annu Rev Physiol. 1989;51:755-70
references.pmid: 2653204
references.citation: Hepatology. 2007 Nov;46(5):1597-610
references.pmid: 17668877
references.citation: Am J Physiol. 1968 Apr;214(4):866-74
references.pmid: 5642950
references.citation: J Cell Biol. 1984 Mar;98(3):991-1000
references.pmid: 6699096
references.citation: J Lipid Res. 1994 Oct;35(10):1738-48
references.pmid: 7852851
references.citation: Science. 2004 Feb 20;303(5661):1201-4
references.pmid: 14976318
references.citation: Liver. 2001 Aug;21(4):247-53
references.pmid: 11454187
references.citation: Nat Genet. 1993 Dec;5(4):327-37
references.pmid: 8298639
references.citation: Semin Liver Dis. 2000;20(3):307-21
references.pmid: 11076398
references.citation: Hum Mutat. 2010 May;31(5):569-77
references.pmid: 20333758
references.citation: Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4028-33
references.pmid: 9108099
references.citation: J Pharmacol Exp Ther. 2006 Aug;318(2):521-9
references.pmid: 16702441
references.citation: Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1221-7
references.pmid: 17272513
references.citation: Adv Enzyme Regul. 1997;37:321-33
references.pmid: 9381978
references.citation: J Clin Invest. 1974 Feb;53(2):526-35
references.pmid: 11344566
references.citation: Hepatology. 2012 Mar;55(3):953-64
references.pmid: 22095670
references.citation: Hepatology. 2004 Mar;39(3):581-90
references.pmid: 14999673
references.citation: Pharmacol Rev. 2010 Mar;62(1):1-96
references.pmid: 20103563
references.citation: Curr Drug Metab. 2004 Feb;5(1):21-53
references.pmid: 14965249
references.citation: Proc Natl Acad Sci U S A. 1987 Nov;84(21):7735-8
references.pmid: 2444983
references.citation: Am J Physiol. 1997 Nov;273(5):G1061-70
references.pmid: 9374703
references.citation: Hepatology. 2001 Apr;33(4):783-91
references.pmid: 11283840
references.citation: J Biol Chem. 1997 May 16;272(20):12984-8
references.pmid: 9148905
references.citation: J Biol Chem. 2003 Dec 19;278(51):51085-90
references.pmid: 14527955
references.citation: J Biol Chem. 1996 Dec 20;271(51):32599-604
references.pmid: 8955087
references.citation: Experientia. 1977 Aug 15;33(8):1055-6
references.pmid: 891809
references.citation: Hepatology. 1987 Mar-Apr;7(2):216-23
references.pmid: 3557300
references.citation: Mol Pharmacol. 2005 May;67(5):1629-38
references.pmid: 15692145
references.citation: J Biol Chem. 2010 Jun 18;285(25):19299-307
references.pmid: 20404332
references.citation: J Gastrointest Surg. 2011 Jun;15(6):996-1004
references.pmid: 21359593
references.citation: J Biol Chem. 2003 May 16;278(20):17664-71
references.pmid: 12637526
references.citation: J Biol Chem. 2001 Aug 3;276(31):28857-65
references.pmid: 11387316
references.citation: Clin Pharmacol Ther. 2001 Apr;69(4):223-31
references.pmid: 11309550
references.citation: Am J Physiol. 1966 May;210(5):1153-9
references.pmid: 5947262
references.citation: J Biol Chem. 1997 Oct 17;272(42):26340-5
references.pmid: 9334206
references.citation: J Clin Invest. 1995 Jan;95(1):31-8
references.pmid: 7814632
references.citation: Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6914-9
references.pmid: 10359813
references.citation: Pharmacol Rev. 1959 Mar;11(1):109-34
references.pmid: 13633440
references.citation: J Gastroenterol Hepatol. 2000 Mar;15(3):244-53
references.pmid: 10764023
references.citation: Nature. 1994 Dec 8;372(6506):549-52
references.pmid: 7990927
references.citation: Hepatology. 2009 Aug;50(2):510-7
references.pmid: 19642168
references.citation: J Clin Invest. 1997 Sep 15;100(6):1349-62
references.pmid: 9294100
references.citation: J Lipid Res. 2010 Feb;51(2):226-46
references.pmid: 19638645
references.citation: Hepatology. 2009 Oct;50(4):1227-40
references.pmid: 19591196
references.citation: Am J Physiol. 1994 Mar;266(3 Pt 1):G382-7
references.pmid: 8166278
references.citation: Am J Physiol. 1996 Dec;271(6 Pt 1):G1043-52
references.pmid: 8997249
references.citation: J Hepatol. 2004 Oct;41(4):528-37
references.pmid: 15464232
references.citation: Gastroenterology. 2009 Mar;136(3):1060-9
references.pmid: 19027009
references.citation: Methods Enzymol. 1990;192:517-33
references.pmid: 2074806
references.citation: J Biol Chem. 1986 May 15;261(14):6216-21
references.pmid: 2871024
references.citation: Gastroenterology. 2001 Jul;121(1):140-7
references.pmid: 11438503
references.citation: Annu Rev Pharmacol Toxicol. 2006;46:381-410
references.pmid: 16402910
references.citation: Am J Physiol. 1995 Oct;269(4 Pt 1):G467-75
references.pmid: 7485497
references.citation: J Biol Chem. 1996 Jun 21;271(25):15211-21
references.pmid: 8662994
references.citation: Am J Physiol. 1980 Jan;238(1):G10-7
references.pmid: 7356024
references.citation: Am J Physiol. 1996 Mar;270(3 Pt 1):G418-24
references.pmid: 8638707
references.citation: Gastroenterology. 2001 May;120(6):1459-67
references.pmid: 11313316
references.citation: J Biol Chem. 2005 Feb 25;280(8):6960-8
references.pmid: 15563450
references.citation: Hepatology. 2007 Mar;45(3):695-704
references.pmid: 17326144
references.citation: Am J Physiol. 1954 Apr;177(1):103-12
references.pmid: 13148351
references.citation: Hepatology. 1997 Feb;25(2):263-9
references.pmid: 9021932
references.citation: J Hepatol. 2006 Jan;44(1):240-2
references.pmid: 16290310
references.citation: BMJ. 2001 Feb 3;322(7281):290-2
references.pmid: 11157536
references.citation: J Nutr. 1983 Apr;113(4):893-8
references.pmid: 6834154
references.citation: Science. 2009 Jan 23;323(5913):474-7
references.pmid: 19164740
references.citation: Gastroenterology. 2002 Jun;122(7):1954-66
references.pmid: 12055601
references.citation: Hepatology. 2003 Nov;38(5):1199-209
references.pmid: 14578858
references.citation: Pharm Res. 2008 May;25(5):1134-41
references.pmid: 18080173
references.citation: Gastroenterology. 1999 Dec;117(6):1370-9
references.pmid: 10579978
references.citation: J Cell Biol. 1997 Jul 28;138(2):307-21
references.pmid: 9230073
references.citation: Hoppe Seylers Z Physiol Chem. 1975 Aug;356(8):1225-44
references.pmid: 1176090
references.citation: Am J Physiol. 1995 Jul;269(1 Pt 1):G167-71
references.pmid: 7631796
references.citation: Biol Res. 2008;41(1):33-42
references.pmid: 18769761
references.citation: Gastroenterology. 1996 Jan;110(1):199-209
references.pmid: 8536857
references.citation: Gastroenterology. 1999 Nov;117(5):1173-80
references.pmid: 10535881
references.citation: J Biol Chem. 1993 May 15;268(14):10448-57
references.pmid: 8486699
references.citation: Proc Natl Acad Sci U S A. 2004 May 18;101(20):7711-5
references.pmid: 15128933
references.citation: J Biol Chem. 1998 Jun 12;273(24):14659-62
references.pmid: 9614059
references.citation: Hepatology. 2008 Jan;47(1):268-78
references.pmid: 17948906
references.citation: Am J Physiol. 1992 Jun;262(6 Pt 1):G1079-86
references.pmid: 1616038
references.citation: Hum Mol Genet. 2000 May 1;9(8):1209-17
references.pmid: 10767346
references.citation: Hepatology. 2009 Nov;50(5):1588-96
references.pmid: 19821532
references.citation: Antioxid Redox Signal. 2005 May-Jun;7(5-6):788-94
references.pmid: 15890026
references.citation: Gastroenterology. 1993 Dec;105(6):1857-64
references.pmid: 7504645
references.citation: Drug Metab Dispos. 2001 Nov;29(11):1467-72
references.pmid: 11602523
references.citation: Am J Physiol. 1997 Aug;273(2 Pt 1):G518-29
references.pmid: 9277433
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 Oct;281(4):G1059-67
references.pmid: 11557527
references.citation: Gastroenterology. 1993 Feb;104(2):604-12
references.pmid: 8425704
references.citation: Am J Pathol. 1994 Nov;145(5):1237-45
references.pmid: 7977654
references.citation: Hepatology. 1998 Aug;28(2):286-95
references.pmid: 9695989
references.citation: Hepatology. 2000 Mar;31(3):555-61
references.pmid: 10706542
references.citation: Hum Mutat. 2001 Oct;18(4):359-60
references.pmid: 11668628
references.citation: Handb Exp Pharmacol. 2011;(201):299-323
references.pmid: 21103974
references.citation: Exp Cell Res. 2007 Oct 1;313(16):3517-25
references.pmid: 17825285
references.citation: Annu Rev Physiol. 1989;51:161-76
references.pmid: 2653179
references.citation: Am J Physiol. 1991 Aug;261(2 Pt 1):G305-11
references.pmid: 1872399
references.citation: Biometals. 2011 Feb;24(1):159-70
references.pmid: 20981470
references.citation: J Biomed Sci. 2005 Oct;12(5):741-61
references.pmid: 16132117
references.citation: Am J Physiol. 1979 May;236(5):E539-44
references.pmid: 35981
references.citation: Pharmacogenet Genomics. 2010 Jan;20(1):45-57
references.pmid: 20010382
references.citation: Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G640-9
references.pmid: 16282361
references.citation: Hepatology. 2009 Jan;49(1):141-50
references.pmid: 19085910
references.citation: World J Gastroenterol. 2008 Dec 14;14(46):7059-67
references.pmid: 19084912
references.citation: Drug Metab Dispos. 2010 Oct;38(10):1673-8
references.pmid: 20601550
references.citation: J Neurochem. 2010 Oct;115(1):220-33
references.pmid: 20649839
references.citation: Hepatology. 1996 May;23(5):1061-6
references.pmid: 8621134
references.citation: Gastroenterology. 2011 Nov;141(5):1927-37.e1-4
references.pmid: 21820390
references.citation: J Biol Chem. 1998 Aug 14;273(33):20828-36
references.pmid: 9694828
references.citation: Am J Physiol. 1989 May;256(5 Pt 1):G826-32
references.pmid: 2719107
references.citation: Am J Physiol. 1995 Sep;269(3 Pt 1):G319-27
references.pmid: 7573441
references.citation: Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1124-30
references.pmid: 16423920
references.citation: Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G570-80
references.pmid: 18635603
references.citation: Science. 2000 Dec 1;290(5497):1771-5
references.pmid: 11099417
references.citation: J Hepatol. 2004 Jan;40(1):24-30
references.pmid: 14672610
references.citation: J Hepatol. 2004 Feb;40(2):212-8
references.pmid: 14739090
references.citation: Nat Genet. 2001 Apr;27(4):375-82
references.pmid: 11279518
references.citation: Hepatology. 2008 Nov;48(5):1665-70
references.pmid: 18688880
references.citation: Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2011-6
references.pmid: 11172067
references.citation: Gastroenterology. 2012 Jun;142(7):1581-91.e6
references.pmid: 22370478
references.citation: Hepatology. 2000 Mar;31(3):684-93
references.pmid: 10706559
references.citation: Semin Liver Dis. 2002 Aug;22(3):251-62
references.pmid: 12360419
references.citation: Eur J Clin Invest. 1975 Feb;5(1):1-6
references.pmid: 1122919
references.citation: J Biol Chem. 2003 Nov 28;278(48):48275-82
references.pmid: 14504269
references.citation: J Hepatol. 1991 Sep;13(2):169-78
references.pmid: 1744421
references.citation: Am J Physiol Gastrointest Liver Physiol. 2006 Jan;290(1):G66-73
references.pmid: 16081764
references.citation: Drug Metab Pharmacokinet. 2009;24(1):37-52
references.pmid: 19252335
references.citation: Am J Physiol. 1991 Jan;260(1 Pt 1):G58-69
references.pmid: 1987808
references.citation: Gastroenterology. 1996 May;110(5):1553-63
references.pmid: 8613063
references.citation: J Membr Biol. 1987;95(3):241-54
references.pmid: 3585979
references.citation: Gastroenterology. 1970 Dec;59(6):853-9
references.pmid: 5486271
references.citation: Mol Pharmacol. 2005 Aug;68(2):551-8
references.pmid: 15911693
references.citation: J Lipid Res. 2003 Feb;44(2):399-407
references.pmid: 12576522
references.citation: Br J Pharmacol. 2012 Jun;166(3):1183-91
references.pmid: 22242910
references.citation: Hepatol Res. 2004 Oct;30(2):91-95
references.pmid: 15519273
references.citation: J Hepatol. 2003 Feb;38(2):148-55
references.pmid: 12547402
references.citation: J Clin Invest. 2002 Sep;110(5):659-69
references.pmid: 12208867
references.citation: Biochim Biophys Acta. 1999 Dec 6;1461(2):377-94
references.pmid: 10581368
references.citation: Dig Dis. 2011;29(1):6-12
references.pmid: 21691098
references.citation: Hepatology. 1983 May-Jun;3(3):433-6
references.pmid: 6682398
references.citation: Am J Physiol. 1984 Dec;247(6 Pt 1):G736-48
references.pmid: 6507626
references.citation: Semin Liver Dis. 1996 May;16(2):169-89
references.pmid: 8781022
references.citation: Physiol Rev. 1985 Apr;65(2):238-309
references.pmid: 3885271
references.citation: Mol Pharmacol. 2011 Feb;79(2):241-50
references.pmid: 21056966
references.citation: Gastroenterology. 2006 Sep;131(3):878-84
references.pmid: 16952556
references.citation: Gastroenterology. 2000 Feb;118(2):422-30
references.pmid: 10648470
references.citation: Cancer Res. 1984 Aug;44(8):3454-66
references.pmid: 6204745
references.citation: Hepatology. 2006 May;43(5):1013-21
references.pmid: 16628672
references.citation: J Biol Chem. 2003 Sep 26;278(39):38084-93
references.pmid: 12867411
references.citation: Dig Dis Sci. 1997 Jun;42(6):1290-4
references.pmid: 9201097
references.citation: Hepatology. 2011 Apr;53(4):1377-87
references.pmid: 21480339
references.citation: Am J Physiol. 1976 Apr;230(4):970-3
references.pmid: 4983
references.citation: Gastroenterology. 2001 Aug;121(2):407-19
references.pmid: 11487550
references.citation: Hepatology. 1995 Jul;22(1):262-6
references.pmid: 7601420
references.citation: Hepatology. 1985 Jul-Aug;5(4):573-9
references.pmid: 4018730
references.citation: J Biol Chem. 2005 Sep 30;280(39):33687-92
references.pmid: 16027164
references.citation: Auk. 2010 Oct;127(4):820-831
references.pmid: 21113274
references.citation: J Biol Chem. 1996 Jun 21;271(25):15091-8
references.pmid: 8662992
references.citation: J Hepatol. 2005 Sep;43(3):472-7
references.pmid: 15922475
references.citation: Gastroenterology. 2002 Nov;123(5):1649-58
references.pmid: 12404239
references.citation: J Hepatol. 2006 Dec;45(6):825-35
references.pmid: 16935383
references.citation: Am J Physiol Gastrointest Liver Physiol. 2012 Feb 15;302(4):G447-59
references.pmid: 22135310
references.citation: Nat Clin Pract Gastroenterol Hepatol. 2006 Oct;3(10):574-85
references.pmid: 17008927
references.citation: Mol Cell Biol. 2009 Dec;29(23):6170-81
references.pmid: 19805516
references.citation: Cochrane Database Syst Rev. 2000;(2):CD000222
references.pmid: 10796703
references.citation: Biochim Biophys Acta. 1976 Nov 11;455(1):152-62
references.pmid: 990323
references.citation: J Biol Chem. 1999 Apr 16;274(16):10852-62
references.pmid: 10196162
references.citation: Drug Metab Dispos. 2005 Mar;33(3):434-9
references.pmid: 15608127
references.citation: J Biol Chem. 1997 Aug 22;272(34):21461-6
references.pmid: 9261163
references.citation: J Hepatol. 1996 Sep;25(3):349-61
references.pmid: 8895015
references.citation: FEBS Lett. 2007 Oct 2;581(24):4616-20
references.pmid: 17825296
references.citation: Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G268-76
references.pmid: 10915634
references.citation: Br J Pharmacol. 2012 Mar;165(5):1260-87
references.pmid: 22013971
references.citation: J Cell Biol. 1985 Dec;101(6):2113-23
references.pmid: 4066752
references.citation: Gastroenterology. 1981 Oct;81(4):773-6
references.pmid: 7262521
references.citation: J Biol Chem. 2000 Jan 28;275(4):2905-10
references.pmid: 10644759
references.citation: Biochem Pharmacol. 1980 Feb;29(2):213-9
references.pmid: 6767480
references.citation: Hepatology. 1984 Sep-Oct;4(5 Suppl):46S-50S
references.pmid: 6384005
references.citation: Physiol Biochem Zool. 2010 Mar-Apr;83(2):308-21
references.pmid: 20113173
references.citation: J Biol Chem. 2000 Aug 4;275(31):23530-9
references.pmid: 10918072
references.citation: Hepatology. 2005 Jan;41(1):168-76
references.pmid: 15619241
references.citation: J Clin Invest. 1974 Oct;54(4):773-81
references.pmid: 4610005
references.citation: Cell Mol Life Sci. 2008 Aug;65(16):2461-83
references.pmid: 18488143
references.citation: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9948-53
references.pmid: 8790437
references.citation: Handb Exp Pharmacol. 2011;(201):105-67
references.pmid: 21103969
references.citation: Pharmacogenomics J. 2008 Feb;8(1):42-52
references.pmid: 17404579
references.citation: Mol Cell Biol. 2001 Feb;21(4):1393-403
references.pmid: 11158324
references.citation: Hepatology. 2012 May;55(5):1485-94
references.pmid: 22105759
references.citation: Hepatology. 1995 Nov;22(5):1469-73
references.pmid: 7590665
references.citation: Biochem J. 2000 Aug 15;350 Pt 1:207-13
references.pmid: 10926845
references.citation: Nature. 1997 May 22;387(6631):414-7
references.pmid: 9163428
references.citation: Gastroenterology. 2011 May;140(5):1664-74
references.pmid: 21315718
references.citation: Hepatology. 2003 Jun;37(6):1435-41
references.pmid: 12774023
references.citation: Semin Liver Dis. 1996 May;16(2):221-9
references.pmid: 8781026
references.citation: Gastroenterology. 2004 Feb;126(2):541-53
references.pmid: 14762791
references.citation: Cancer Metastasis Rev. 2007 Mar;26(1):5-14
references.pmid: 17273943
references.citation: Experientia. 1975 Oct 15;31(10):1191-3
references.pmid: 1204737
references.citation: Biochim Biophys Acta. 2008 May;1783(5):673-94
references.pmid: 18302942
references.citation: Life Sci. 1982 Nov 1;31(18):1973-85
references.pmid: 7176806
references.citation: Gastroenterology. 1997 Nov;113(5):1734-40
references.pmid: 9352879
references.citation: Biochemistry. 2005 Sep 20;44(37):12598-605
references.pmid: 16156672
references.citation: J Clin Invest. 1982 Sep;70(3):505-17
references.pmid: 6286725
references.citation: Hepatology. 2000 Dec;32(6):1342-56
references.pmid: 11093742
references.citation: J Lipid Res. 2008 May;49(5):973-84
references.pmid: 18270374
references.citation: J Biol Chem. 1998 Jun 26;273(26):16184-91
references.pmid: 9632674
references.citation: Cell. 1994 Jul 1;77(7):1071-81
references.pmid: 7912658
references.citation: J Clin Invest. 1991 May;87(5):1503-12
references.pmid: 2022723
references.citation: Hepatology. 1994 Jun;19(6):1400-6
references.pmid: 8188169
references.citation: Am J Physiol Gastrointest Liver Physiol. 2002 Jul;283(1):G222-9
references.pmid: 12065310
references.citation: Hepatology. 2000 Jun;31(6):1313-7
references.pmid: 10827157
references.citation: Physiol Rev. 2003 Apr;83(2):633-71
references.pmid: 12663868
references.citation: Am J Physiol. 1989 Jan;256(1 Pt 1):G22-30
references.pmid: 2912148
references.citation: Gastroenterology. 1997 Jul;113(1):311-21
references.pmid: 9207292
references.citation: J Physiol. 1975 Mar;245(3):567-82
references.pmid: 1142218
references.citation: Mol Pharmacol. 2005 May;67(5):1758-64
references.pmid: 15709111
references.citation: N Engl J Med. 2009 Oct 1;361(14):1359-67
references.pmid: 19797282
references.citation: J Biol Chem. 1993 Aug 25;268(24):17734-41
references.pmid: 8394349
references.citation: Am J Physiol. 1996 Jul;271(1 Pt 1):G137-46
references.pmid: 8760117
references.citation: J Clin Invest. 1997 Jun 15;99(12):2906-14
references.pmid: 9185514
references.citation: Semin Liver Dis. 1987 Nov;7(4):280-92
references.pmid: 3324347
references.citation: Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15087-92
references.pmid: 16214890
references.citation: Hepatology. 2012 Jun;55(6):1901-11
references.pmid: 22161577
references.citation: J Biol Chem. 1991 Oct 5;266(28):18920-6
references.pmid: 1918007
references.citation: Gastroenterology. 2001 Mar;120(4):967-74
references.pmid: 11231950
references.citation: J Pediatr. 2007 May;150(5):556-9
references.pmid: 17452236
references.citation: J Biol Chem. 2008 Oct 17;283(42):28401-12
references.pmid: 18694937
references.citation: J Clin Invest. 1993 Sep;92(3):1314-25
references.pmid: 8397224
references.citation: Gastroenterology. 2005 Aug;129(2):735-40
references.pmid: 16083726
references.citation: Gastroenterology. 1995 Nov;109(5):1600-11
references.pmid: 7557144
references.citation: Gastroenterology. 1994 May;106(5):1349-64
references.pmid: 8174894
references.citation: Hepatology. 2003 Mar;37(3):622-31
references.pmid: 12601360
references.citation: Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G327-36
references.pmid: 15374814
references.citation: Hepatology. 1996 Apr;23(4):904-8
references.pmid: 8666348
references.citation: N Engl J Med. 1991 May 16;324(20):1408-11
references.pmid: 2020296
references.citation: Pharm Res. 2007 Jul;24(7):1227-51
references.pmid: 17473959
references.citation: Mol Pharmacol. 2005 Jul;68(1):160-8
references.pmid: 15814571
references.citation: J Pharmacol Exp Ther. 2006 May;317(2):579-89
references.pmid: 16421286
references.citation: Am J Physiol Cell Physiol. 2007 Nov;293(5):C1709-16
references.pmid: 17855769
references.citation: Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G771-81
references.pmid: 21330447
references.citation: Biochem J. 2003 Apr 15;371(Pt 2):361-7
references.pmid: 12523936
references.citation: Gastroenterology. 2008 Apr;134(4):1203-14
references.pmid: 18395098
references.citation: Hepatology. 2008 Nov;48(5):1558-69
references.pmid: 18798335
references.citation: Gastroenterology. 1996 Jul;111(1):193-8
references.pmid: 8698199
references.citation: J Biol Chem. 2001 Oct 5;276(40):37206-14
references.pmid: 11483603
references.citation: Hepatology. 2000 Aug;32(2):348-56
references.pmid: 10915742
references.citation: Hepatology. 1994 May;19(5):1208-13
references.pmid: 8175143
references.citation: Prog Liver Dis. 1995;13:63-99
references.pmid: 9224498
references.citation: Mol Pharmacol. 2010 Oct;78(4):617-30
references.pmid: 20631053
references.citation: J Clin Invest. 1988 Feb;81(2):569-78
references.pmid: 2448343
references.citation: Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G316-24
references.pmid: 12702492
references.citation: Hepatology. 2002 Jul;36(1):65-71
references.pmid: 12085350
references.citation: Am J Physiol. 1997 Oct;273(4):G842-8
references.pmid: 9357825
references.citation: Gastroenterology. 2001 Jul;121(1):156-69
references.pmid: 11438505
references.citation: Hepatology. 2003 Aug;38(2):374-84
references.pmid: 12883481
references.citation: Gastroenterology. 2001 Dec;121(6):1473-84
references.pmid: 11729126
references.citation: J Clin Invest. 1997 Dec 1;100(11):2714-21
references.pmid: 9389734
references.citation: Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6527-31
references.pmid: 7541542
references.citation: Hepatology. 1999 Feb;29(2):506-8
references.pmid: 9918928
references.citation: Semin Liver Dis. 2010 May;30(2):134-46
references.pmid: 20422496
references.citation: Microsc Res Tech. 2006 Sep;69(9):693-707
references.pmid: 16886231
references.citation: Hepatology. 2003 Dec;38(6):1477-88
references.pmid: 14647059
references.citation: World J Gastroenterol. 2008 Jan 7;14(1):38-45
references.pmid: 18176959
references.citation: Lab Invest. 1986 Jun;54(6):593-608
references.pmid: 2423777
references.citation: Pflugers Arch. 2007 Feb;453(5):601-10
references.pmid: 16622704
references.citation: Gastroenterology. 1979 May;76(5 Pt 1):988-96
references.pmid: 220132
references.citation: Front Biosci (Landmark Ed). 2009 Jan 01;14:2829-44
references.pmid: 19273238
references.citation: Life Sci. 1996;59(15):1237-46
references.pmid: 8845010
references.citation: Hepatology. 2012 Jun;55(6):1889-900
references.pmid: 22262466
references.citation: Am J Physiol. 1984 Jan;246(1 Pt 1):G67-71
references.pmid: 6696069
references.citation: Am J Physiol. 1971 Oct;221(4):1156-63
references.pmid: 4255749
references.citation: Hepatology. 2010 Aug;52(2):667-77
references.pmid: 20683964
references.citation: Biochem J. 1996 Jun 15;316 ( Pt 3):901-4
references.pmid: 8670169
references.citation: Am J Physiol. 1978 Nov;235(5):E570-6
references.pmid: 727257
references.citation: J Biol Chem. 2006 Sep 22;281(38):27669-73
references.pmid: 16737964
references.citation: J Lipid Res. 2009 Nov;50(11):2139-47
references.pmid: 19357427
references.citation: Physiol Rev. 1953 Jul;33(3):387-423
references.pmid: 13088295
references.citation: Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):282-7
references.pmid: 9419367
references.citation: J Biol Chem. 2004 Jul 30;279(31):32761-70
references.pmid: 15159385
references.citation: Annu Rev Pharmacol Toxicol. 1999;39:361-98
references.pmid: 10331089
references.citation: Mol Pharmacol. 2009 Jan;75(1):143-50
references.pmid: 18829893
references.citation: J Physiol. 1976 Oct;261(2):337-57
references.pmid: 978576
references.citation: Hepatology. 1991 Sep;14(3):551-66
references.pmid: 1874500
references.citation: J Physiol. 2006 Jun 15;573(Pt 3):611-25
references.pmid: 16581855
references.citation: J Biol Chem. 2003 Oct 31;278(44):43157-62
references.pmid: 12939275
references.citation: J Cell Biol. 1995 Oct;131(1):137-50
references.pmid: 7559771
references.citation: Drug Metab Pharmacokinet. 2008;23(4):223-35
references.pmid: 18762709
references.citation: J Biol Chem. 1998 Oct 9;273(41):26638-44
references.pmid: 9756904
references.citation: Gastroenterology. 2007 Nov;133(5):1592-602
references.pmid: 17916355
references.citation: Hepatology. 1998 Apr;27(4):893-9
references.pmid: 9537426
references.citation: Am J Physiol. 1990 Nov;259(5 Pt 1):G727-35
references.pmid: 2173414
references.citation: J Immunol. 1982 Mar;128(3):1181-7
references.pmid: 7057034
references.citation: J Clin Invest. 1980 Feb;65(2):277-84
references.pmid: 7356679
references.citation: Am J Physiol. 1988 Aug;255(2 Pt 1):G253-9
references.pmid: 3407780
references.citation: Biochem Biophys Res Commun. 2000 Apr 21;270(3):728-32
references.pmid: 10772892
references.citation: World J Gastroenterol. 2010 Dec 21;16(47):5936-45
references.pmid: 21157969
references.citation: J Pharmacol Exp Ther. 2006 Dec;319(3):1485-91
references.pmid: 16988054
references.citation: Liver Int. 2007 Sep;27(7):920-9
references.pmid: 17696930
references.citation: J Pharmacol Exp Ther. 2007 Feb;320(2):559-64
references.pmid: 17135346
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R1809-22
references.pmid: 17761511
references.citation: Mol Pharmacol. 2006 May;69(5):1554-63
references.pmid: 16449384
references.citation: Semin Liver Dis. 2000;20(3):265-72
references.pmid: 11076395
references.citation: Trends Pharmacol Sci. 2008 Apr;29(4):200-7
references.pmid: 18353444
references.citation: J Clin Invest. 2012 Feb;122(2):519-28
references.pmid: 22232210
references.citation: Hepatology. 1989 Jul;10(1):8-13
references.pmid: 2737605
references.citation: J Clin Invest. 1997 Nov 15;100(10):2562-7
references.pmid: 9366571
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G316-22
references.pmid: 11447010
references.citation: J Clin Invest. 1991 Aug;88(2):712-6
references.pmid: 1713921
references.citation: Biochem J. 1998 Nov 15;336 ( Pt 1):33-7
references.pmid: 9806881
references.citation: Gastroenterology. 2001 May;120(6):1448-58
references.pmid: 11313315
references.citation: J Clin Invest. 1978 Nov;62(5):1104-8
references.pmid: 213446
references.citation: Hepatology. 2004 Jul;40(1):27-38
references.pmid: 15239083
references.citation: Hepatology. 2010 May;51(5):1645-55
references.pmid: 20232290