title: Multiple myeloma following essential thrombocythemia.
abstract: The association of essential thrombocythemia and multiple myeloma is extremely rare, with only three patients previously treated with hydroxyurea reported in the literature until now. In this paper, we report the case of a 66 year old male who developed IgG-kappa M six years after the diagnosis of essential thrombocythemia, for which he had received hydroyurea. The possible etiological and pathogenic link between both these entities is here discussed.
authors.affiliation: Department of clinical hematology Farhat Hached, University Hospital, Sousse, Tunisia. yosra.benyoussef@laposte.net
authors.forename: Yosra
authors.initials: Y
authors.lastname: Ben Youssef
authors.forename: Abir
authors.initials: A
authors.lastname: Gmidène
authors.forename: Zahreddine
authors.initials: Z
authors.lastname: Bouabid
authors.forename: Sonia
authors.initials: S
authors.lastname: Bouallegui
authors.forename: Badreddine
authors.initials: B
authors.lastname: Sriha
authors.forename: Monia
authors.initials: M
authors.lastname: Zaier
authors.forename: Hlima
authors.initials: H
authors.lastname: Sennana
authors.forename: Abserrahim
authors.initials: A
authors.lastname: Khelif
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007155:Immunologic Factors / Q000032:analysis; D008297:Male; D009101:Multiple Myeloma / Q000209:etiology*; D019384:Nucleic Acid Synthesis Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D010950:Plasma Cells / Q000473:pathology; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000188:drug therapy
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007155:Immunologic Factors; D019384:Nucleic Acid Synthesis Inhibitors; D006918:Hydroxyurea
keywords: essential thrombocythemia; hydroxyurea; multiple myeloma