title: A novel human coronavirus: Middle East respiratory syndrome human coronavirus.
abstract: In 2012, a novel coronavirus, initially named as human coronavirus EMC (HCoV-EMC) but recently renamed as Middle East respiratory syndrome human coronavirus (MERS-CoV), was identified in patients who suffered severe acute respiratory infection and subsequent renal failure that resulted in death. Ongoing epidemiological investigations together with retrospective studies have found 61 laboratory-confirmed cases of infection with this novel coronavirus, including 34 deaths to date. This novel coronavirus is culturable and two complete genome sequences are now available. Furthermore, molecular detection and indirect immunofluorescence assay have been developed. The present paper summarises the limited recent advances of this novel human coronavirus, including its discovery, genomic characterisation and detection.
authors.affiliation: Biotech Center for Viral Disease Emergency, Key Laboratory of Medical Virology and Viral Diseases Prevention and Control, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: HeYuan
authors.initials: H
authors.lastname: Geng
authors.forename: WenJie
authors.initials: W
authors.lastname: Tan
mesh_terms: D000328:Adult; D000368:Aged; D001483:Base Sequence; D017934:Coronavirus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D018352:Coronavirus Infections / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D016679:Genome, Viral; D006801:Humans; D008297:Male; D008875:Middle Aged; D008877:Middle East; D010802:Phylogeny; D012141:Respiratory Tract Infections / Q000821:virology*; D013577:Syndrome
chemical_list: D004279:DNA, Viral
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