title: Diffuse capillary malformation with overgrowth: a clinical subtype of vascular anomalies with hypertrophy.
abstract: BACKGROUND
  Categorization of vascular anomalies with overgrowth is evolving rapidly with the aid of massively parallel genomic sequencing; however, accurate clinical diagnosis is still essential. We identified a group of patients with an extensive, diffuse, reticulate capillary malformation (CM) and variable hypertrophy without major complications.
  
  
  OBJECTIVE
  We sought to study a subset of patients with diffuse CM to better define prognosis and management.
  
  
  METHODS
  Chart review identified 73 patients with diffuse CM who did not fit the criteria for known disorders with CM and/or overgrowth.
  
  
  RESULTS
  Soft-tissue or bony overgrowth did not correlate with location, morphology, or intensity of the vascular stain. Patients required periodic follow-up to monitor for leg length discrepancy. They were found to exhibit normal neurologic development and proportionate overgrowth rather than progressive, disproportionate asymmetry or vascular complications.
  
  
  CONCLUSIONS
  This retrospective review was limited to observations documented at clinic visits; these patients require long-term assessment. Further studies are necessary to accurately assess Wilms tumor risk and clinical outcomes in older adults.
  
  
  CONCLUSIONS
  We propose the term "diffuse capillary malformation with overgrowth" to designate this extensive reticular vascular staining with proportionate overgrowth. We differentiate diffuse capillary malformation with overgrowth from other disorders with CM and hypertrophy.
authors.affiliation: Dermatology Program, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: margaret.lee@childrens.harvard.edu.
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Lee
authors.forename: Marilyn G
authors.initials: MG
authors.lastname: Liang
authors.forename: John B
authors.initials: JB
authors.lastname: Mulliken
mesh_terms: D000015:Abnormalities, Multiple / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D000328:Adult; D000367:Age Factors; D002196:Capillaries / Q000002:abnormalities*; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000473:pathology* / Q000503:physiopathology; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D009626:Terminology as Topic; D054079:Vascular Malformations / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology
keywords: CLOVES; CLVM; CM; CMTC; DCMO; KTS; Klippel-Trenaunay syndrome; LM; M-CM; VM; capillary malformation; capillary-lymphatic-venous malformation; congenital lipomatous overgrowth and vascular malformation with epidermal nevus and skeletal abnormalities; cutis marmorata telangiectatica congenita; diffuse capillary malformation with overgrowth; hemihyperplasia; hemihypertrophy; hyperplasia; hypertrophy; lymphatic malformation; macrocephaly-capillary malformation syndrome; overgrowth; venous malformation