title: Serum insulin-like growth factor 1 correlates with the risk of nodal metastasis in endocrine-positive breast cancer.
abstract: Increased insulin-like growth factor (igf) signalling has been observed in breast cancer, including endocrine-responsive cancers, and has been linked to disease progression and recurrence. In particular, igf-1 has the ability to induce and promote lymphangiogenesis through the induction of vascular endothelial growth factor C (vegfc). In the present study, we analyzed serum and tumour samples from 60 patients with endocrine-positive breast cancer to determine the expression and the possible relationship of circulating igf-1, igf binding protein 3 (igfbp3), and vegfc with the presence of lymphatic metastasis and other immunohistochemical parameters. The analysis revealed a clear and significant correlation between high basal levels of igf-1, igfbp3, and vegfc and lymph node metastasis in endocrine-responsive breast cancer. In addition, expression of those molecules was significantly higher in breast cancer patients than in healthy control subjects. Those findings may enable more accurate prediction of prognosis in patients with breast cancer.
authors.affiliation: Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale "F.Magrassi e A. Lanzara", Seconda Università degli Studi di Napoli, Napoli, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Morgillo
authors.forename: F
authors.initials: F
authors.lastname: De Vita
authors.forename: G
authors.initials: G
authors.lastname: Antoniol
authors.forename: M
authors.initials: M
authors.lastname: Orditura
authors.forename: P P
authors.initials: PP
authors.lastname: Auriemma
authors.forename: M R
authors.initials: MR
authors.lastname: Diadema
authors.forename: E
authors.initials: E
authors.lastname: Lieto
authors.forename: B
authors.initials: B
authors.lastname: Savastano
authors.forename: L
authors.initials: L
authors.lastname: Festino
authors.forename: M M
authors.initials: MM
authors.lastname: Laterza
authors.forename: A
authors.initials: A
authors.lastname: Fabozzi
authors.forename: J
authors.initials: J
authors.lastname: Ventriglia
authors.forename: A
authors.initials: A
authors.lastname: Petrillo
authors.forename: F
authors.initials: F
authors.lastname: Ciardiello
authors.forename: A
authors.initials: A
authors.lastname: Barbarisi
authors.forename: F
authors.initials: F
authors.lastname: Iovino
keywords: Breast cancer; igf-1; vegfc
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