title: Star-shaped poly(styrene)-block-poly(4-vinyl-N-methylpyridiniumiodide) for semipermanent antimicrobial coatings.
abstract: Goal of the present work is to develop an antimicrobial coating that can be applied from an aqueous solution and resists short washing cycles, but can be rinsed off by thorough washing. To this end, a series of star-shaped polystyrene-block-poly(4-vinyl-N-methylpyridinium iodide) polymers are synthesized by anionic polymerization using a core-first approach. The optimal resulting polymers are applied as coatings on glass slides, showing high antimicrobial efficiency against Staphylococcus aureus as well as Escherichia coli. The coatings, characterized by atomic force microscopy and transmission electron microscopy, stay at the surface even after at least 20 flush-like washings with water, and retain their antimicrobial activity.
authors.affiliation: Department of Bio- and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, D-44227, Dortmund, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Siedenbiedel
authors.forename: Andreas
authors.initials: A
authors.lastname: Fuchs
authors.forename: Thorsten
authors.initials: T
authors.lastname: Moll
authors.forename: Mirko
authors.initials: M
authors.lastname: Weide
authors.forename: Roland
authors.initials: R
authors.lastname: Breves
authors.forename: Joerg C
authors.initials: JC
authors.lastname: Tiller
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D018625:Microscopy, Atomic Force; D011137:Polystyrenes / Q000008:administration & dosage / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry; D011726:Pyridinium Compounds / Q000008:administration & dosage / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D020058:Styrene / Q000737:chemistry; D013499:Surface Properties / Q000187:drug effects; D014867:Water / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D011137:Polystyrenes; D011726:Pyridinium Compounds; D014867:Water; D020058:Styrene; D011143:Polyvinyl Chloride
keywords: anionic polymerization; antimicrobial; coating; semipermanent; star-shaped polymers