title: Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers.
abstract: The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair. Over the past decades, numerous pathological conditions and developmental syndromes have emerged as a consequence of deregulation in the FGFRs signaling network. This review aims to provide an overview of FGFR family, their complex signaling pathways in tumorigenesis, and the current development and application of therapeutics targeting the FGFRs signaling for treatment of refractory human cancers.
authors.affiliation: School of Postgraduate Studies and Research, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia, kaihung_tiong@imu.edu.my.
authors.forename: Kai Hung
authors.initials: KH
authors.lastname: Tiong
authors.forename: Li Yen
authors.initials: LY
authors.lastname: Mah
authors.forename: Chee-Onn
authors.initials: CO
authors.lastname: Leong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D017468:Receptors, Fibroblast Growth Factor
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