title: Escherichia coli brain abscess in a twin pair associated with TLR4 gene mutation.
abstract: Brain abscesses are uncommon complications of bacterial meningitis or sepsis in neonates and infants. The causative pathogens of brain abscess in newborns are various. Of those, Escherichia coli is rarely seen as a pathogen in brain abscess at this age. Herein we reported brain abscesses in twin infants caused by E. coli sepsis. Interestingly, genetic analysis identified heterozygous Toll-like receptor 4 (TLR4) gene mutation in the twins. Because TLR plays an important role in the natural response to bacterial products and initiates specific immune response against these pathogens, this may explain the development of brain abscess in the present case.
authors.affiliation: Neonatology Clinic, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Erdemir
authors.forename: Zelal
authors.initials: Z
authors.lastname: Kahramaner
authors.forename: Hese
authors.initials: H
authors.lastname: Cosar
authors.forename: Ebru
authors.initials: E
authors.lastname: Turkoglu
authors.forename: Sumer
authors.initials: S
authors.lastname: Sutcuoglu
authors.forename: Dilara Kocacik
authors.initials: DK
authors.lastname: Uygun
authors.forename: Olcay
authors.initials: O
authors.lastname: Yegin
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
authors.forename: Esra Arun
authors.initials: EA
authors.lastname: Ozer
mesh_terms: D001922:Brain Abscess / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D004247:DNA / Q000235:genetics*; D004200:Diseases in Twins; D004926:Escherichia coli / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D051197:Toll-Like Receptor 4 / Q000235:genetics* / Q000378:metabolism
chemical_list: D051197:Toll-Like Receptor 4; D004247:DNA
keywords: Escherichia coli; Toll-like receptor 4; brain abscess; neonates