title: Association between serum fetuin-A levels, carotid artery stiffness, and intima-media thickness in patients with normotensive obstructive sleep apnea syndrome.
abstract: Increased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 ± 6.5 vs 68.2 ± 5.8 ng/mL, P = .029), higher mean cIMT (0.73 ± 0.2 vs 0.63 ± 0.3 mm, P < .001), and greater stiffness (β) index (7.45 ± 0.9 vs 5.2 ± 0.7, P = .001) in the OSAS group. The cIMT and stiffness (β) index were inversely correlated with fetuin-A levels (r = -.324, P = .033; r = -.466, P < .001, respectively) and positively correlated with apnea hypopnea index (r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey ayakyuzq5@gmail.com.
authors.forename: Aydın
authors.initials: A
authors.lastname: Akyuz
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Oran
authors.affiliation: Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Seref
authors.initials: S
authors.lastname: Alpsoy
authors.affiliation: Department of Chest Disease, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Levent Cem
authors.initials: LC
authors.lastname: Mutlu
authors.affiliation: Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Dursun Cayan
authors.initials: DC
authors.lastname: Akkoyun
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Savas
authors.initials: S
authors.lastname: Guzel
authors.affiliation: Department of Neurology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Alp
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D002339:Carotid Arteries / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications*; D059289:Vascular Stiffness / Q000502:physiology*; D060749:alpha-2-HS-Glycoprotein / Q000096:biosynthesis*
chemical_list: C556354:AHSG protein, human; D015415:Biomarkers; D060749:alpha-2-HS-Glycoprotein
keywords: carotid atherosclerosis; fetuin-A; intima–media thickness; obstructive sleep apnea