title: Severity of tegumentary leishmaniasis is not exclusively associated with Leishmania RNA virus 1 infection in Brazil.
abstract: Leishmania RNA virus (LRV) has been shown to be a symbiotic component of Leishmania parasites in South America. Nested retro-transcription polymerase chain reaction was employed to investigate LRV1 presence in leishmaniasis lesions from Brazil. In endemic areas of Rio de Janeiro (RJ), no LRV1 infection was observed even with mucosal involvement. LRV1 was only detected in Leishmania (V.) guyanensis cutaneous lesions from the northern region, which were obtained from patients presenting with disease reactivation after clinical cure of their primary lesions. Our results indicated that the severity of leishmaniasis in some areas of RJ, where Leishmania (V.) brazi-liensis is the primary etiological agent, was not associated with Leishmania LRV1 infection.
authors.affiliation: Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
authors.forename: Luiza de Oliveira Ramos
authors.initials: Lde O
authors.lastname: Pereira
authors.forename: Ana Cláudia
authors.initials: AC
authors.lastname: Maretti-Mira
authors.forename: Káris Maria
authors.initials: KM
authors.lastname: Rodrigues
authors.forename: Rosimar Baptista
authors.initials: RB
authors.lastname: Lima
authors.forename: Manoel Paes de
authors.initials: MP
authors.lastname: Oliveira-Neto
authors.forename: Elisa
authors.initials: E
authors.lastname: Cupolillo
authors.forename: Claude
authors.initials: C
authors.lastname: Pirmez
authors.forename: Márcia Pereira
authors.initials: MP
authors.lastname: de Oliveira
mesh_terms: D001938:Brazil; D005260:Female; D006801:Humans; D007892:Leishmania braziliensis / Q000821:virology*; D016773:Leishmaniasis, Cutaneous / Q000469:parasitology*; D016133:Polymerase Chain Reaction; D012328:RNA Viruses / Q000145:classification / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics; D012720:Severity of Illness Index
chemical_list: D012367:RNA, Viral
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