title: Idiosyncratic drug toxicity affecting the liver, skin, and bone marrow in dogs and cats.
abstract: Idiosyncratic drug toxicity reactions are, by definition, uncommon, but can lead to serious or even fatal organ toxicity. The liver, skin, and peripheral blood cells/bone marrow are common targets. Most of these reactions are the result of reactive metabolites, which may cause local cell or organelle damage, or may be amplified by a systemic immune response. Individual risk may depend on differences in drug biotransformation, levels of oxidative stress, or antigen presentation.
authors.affiliation: School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706-1102, USA. latrepanier@svm.vetmed.wisc.edu
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Trepanier
mesh_terms: D000818:Animals; D001855:Bone Marrow Diseases / Q000139:chemically induced / Q000662:veterinary*; D002371:Cat Diseases / Q000139:chemically induced*; D002415:Cats; D056486:Chemical and Drug Induced Liver Injury / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D003875:Drug Eruptions / Q000662:veterinary*
keywords: Adverse drug reaction; Blood dyscrasia; Hepatotoxicity; Skin eruption