title: [Relationship between dynamic contrast-enhanced and perfusion magnetic resonance imaging and T-staging of nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To perform the dynamic contrast-enhanced and perfusion magnetic resonance imaging (MRI) of nasopharyngeal carcinoma (NPC) and analyze the correlation with T-staging.
  
  
  METHODS
  A total of 46 naïve NPC patients underwent MRI. The parameters of dynamic contrast-enhanced and perfusion MRI included time to peak (TTP), Slopemax and area under the curve (AUC).
  
  
  RESULTS
  The increasing period of signal intensity-time curve of all cases was steep. And the perfusion image of AUC could reflect the blood perfusion of tumor tissue. Parameters (TTP/Slopemax/AUC) in different T-staging were T1-staging (60.45/10.59/20 619.56), T2-staging (58.12/12.47/23 037.23), T3-staging (70.61/15.06/26 507.23) and T4-staging (41.72/19.87/30 092.27). Their statistical results were r = -0.247, P > 0.05 and r = 0.859, P < 0.050 and r = 0.963, P < 0.05 respectively. And statistical significance existed in Slopemax, AUC with T-staging.
  
  
  CONCLUSIONS
  Dynamic contrast-enhanced and perfusion MRI can reflect angiogenesis of NPC. And there is a positive correlation between the parameters of dynamic contrast-enhanced and perfusion MRI (Slopemax, AUC) and T-staging.
authors.affiliation: Department of Radiology, Shenzhen People's Hospital, Shenzhen 518020, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Yang
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Xu
authors.forename: Jing-shan
authors.initials: JS
authors.lastname: Gong
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Jiang-bo
authors.initials: JB
authors.lastname: Yu
authors.forename: Shao-peng
authors.initials: SP
authors.lastname: Zhou
mesh_terms: D000328:Adult; D002277:Carcinoma; D005260:Female; D006801:Humans; D007089:Image Enhancement; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*; D009367:Neoplasm Staging; D055815:Young Adult