title: Telomerase gene screening and telomere overhang detection in Chinese patients with myelodysplastic syndrome.
abstract: BACKGROUND
  Telomerase disfunction leads to short telometric overhangs, potentially resulting in chromosome instability.
  
  
  OBJECTIVE
  To better understand the role of overhang length in the progression of myelodysplastic syndrome (MDS).
  
  
  METHODS
  Bone marrow samples of 62 Chinese MDS patients were screened for TERT and TERC gene variants. Overhangs length was investigated.
  
  
  RESULTS
  No mutation was identified. MDS patients had shorter overhangs compared to controls. Abnormal karyotype ones had shorter overhang compared to normal. Telomeric overhang length decreased as IPSS/WPSS value increased.
  
  
  CONCLUSIONS
  Overhang changes in accordance with IPSS/WPSS in MDS. Short overhang may be an independent factor for poor prognosis in MDS.
authors.affiliation: Department of Hematology, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Siyi
authors.initials: S
authors.lastname: Yan
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Yongji
authors.initials: Y
authors.lastname: Wu
authors.forename: Daobin
authors.initials: D
authors.lastname: Zhou
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000235:genetics*; D011379:Prognosis; D019098:Telomerase / Q000235:genetics* / Q000378:metabolism; D016615:Telomere / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: D019098:Telomerase
keywords: Myelodysplatic syndrome; Prognosis; Telomerase gene mutation; Telomere overhang