title: The impact of darwinian evolution on medicine: the maternal side of the story.
abstract: Complex disorders are common in the human population and are caused by interplay between genetic and environmental factors. Therefore the quest for the genetic basis of such disorders has much similarity to deciphering the genetic basis of macro-evolutionary processes, such as speciation. Here I discuss conceptual connections between the principles underlying and processes occurring in disease and evolution. Special focus is given to the tremendous mitochondrial genetic variability in the population and within individuals and the impact of both types of variability on evolutionary processes and diseases.
authors.affiliation: Department of Life Sciences and the National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Dan
authors.initials: D
authors.lastname: Mishmar
keywords: disease; evolution; evolutionary medicine; mitochondria; next-generation sequencing
references.citation: Nature. 2009 Sep 10;461(7261):272-6
references.pmid: 19684571
references.citation: Genome Res. 2009 Apr;19(4):576-80
references.pmid: 19211544
references.citation: Am J Hum Genet. 1962 Dec;14:353-62
references.pmid: 13937884
references.citation: Nat Genet. 2008 Feb;40(2):249-54
references.pmid: 18223651
references.citation: PLoS Genet. 2009 Dec;5(12):e1000756
references.pmid: 19997484
references.citation: PLoS Genet. 2006 Aug;2(8):e128
references.pmid: 16895436
references.citation: Brain. 2004 Oct;127(Pt 10):2153-72
references.pmid: 15358637
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17993-8
references.pmid: 16332961
references.citation: Am J Hum Genet. 2008 Aug;83(2):254-60
references.pmid: 18674747
references.citation: BMC Med Genet. 2009 Jun 18;10:60
references.pmid: 19534826
references.citation: Philos Ethics Humanit Med. 2007 Apr 03;2:4
references.pmid: 17407602
references.citation: Trends Genet. 2004 Nov;20(11):578-85
references.pmid: 15475118
references.citation: Science. 2004 Jan 9;303(5655):223-6
references.pmid: 14716012
references.citation: Bioessays. 2009 Jun;31(6):642-50
references.pmid: 19408245
references.citation: Oncogene. 2006 Aug 7;25(34):4647-62
references.pmid: 16892079
references.citation: Curr Opin Genet Dev. 2009 Jun;19(3):212-9
references.pmid: 19481926
references.citation: Nature. 2010 Mar 25;464(7288):610-4
references.pmid: 20200521
references.citation: Trends Genet. 2001 Sep;17(9):502-10
references.pmid: 11525833
references.citation: Annu Rev Genet. 2005;39:359-407
references.pmid: 16285865
references.citation: Nucleic Acids Res. 2004 Jun 04;32(10):3053-64
references.pmid: 15181170
references.citation: Mol Genet Metab. 2009 Apr;96(4):189-95
references.pmid: 19185523
references.citation: Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1099-104
references.pmid: 20074547
references.citation: J Evol Biol. 2010 Mar;23(3):528-38
references.pmid: 20070459
references.citation: Trends Ecol Evol. 2004 Dec;19(12):645-53
references.pmid: 16701327
references.citation: BMC Genomics. 2008 Apr 29;9:198
references.pmid: 18445251
references.citation: Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12382-7
references.pmid: 8901590
references.citation: Nat Genet. 2008 Dec;40(12):1484-8
references.pmid: 19029901
references.citation: PLoS Genet. 2009 May;5(5):e1000474
references.pmid: 19424428
references.citation: Oncogene. 2006 Aug 7;25(34):4768-76
references.pmid: 16892089
references.citation: Nature. 2004 May 27;429(6990):417-23
references.pmid: 15164064
references.citation: Lancet. 2006 Jul 1;368(9529):70-82
references.pmid: 16815381
references.citation: Am J Hum Genet. 2007 Mar;80(3):407-15
references.pmid: 17273962
references.citation: Forensic Sci Int. 2008 Mar 5;175(2-3):155-9
references.pmid: 17646069