title: Costly Class-1 integrons and the domestication of the the functional integrase.
abstract: Class-1 integrons play an important role in the emergence and spread of antimicrobial resistance determinants. In a recent study we showed that host fitness was dramatically reduced following acquisition of these elements. These fitness costs were due to the presence of an active integrase and we suggested that the mechanistic explanation was due to reduced genetic stability through IntI1 mediated recombination events betweenattI/attCand non-canonical sites in the chromosome. Here we demonstrate that theattIdegenerated target sequence is highly prevalent in our model organismAcinetobacter baylyiadding support to the hypothesis that IntI1 is costly due to genomic instability.
authors.affiliation: Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Norway.
authors.forename: Klaus
authors.initials: K
authors.lastname: Harms
authors.forename: Irina
authors.initials: I
authors.lastname: Starikova
authors.forename: Pål J
authors.initials: PJ
authors.lastname: Johnsen
keywords: Class-1 integrons; fitness cost of resistance
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