title: [Biomarkers of cardiorenal syndrome].
abstract: Complex interactions existing between cardiac and renal diseases led to define 5 types of so-called cardiorenal syndromes. This classification is based on the organ primarily involved and the acute or chronic failure. The mutual impact of renal and cardiac functions makes it difficult to evaluate and manage patients with cardiorenal syndromes and worsen morbidity and mortality. This review seeks to discuss the place of biomarkers in diagnosis, management and follow-up of patients with cardiorenal syndromes. Biomarkers can be classified as functional (creatinine, cystatin C…) or lesional (neutrophil gelatinase-associated lipocalin, urinary cystatin C…) renal markers and functional (natriuretic peptides…) or lesional (troponin, fatty acid binding protein) cardiac markers. A last kind of biomarkers reflects the dialogue between heart and kidney (renin-angiotensin-aldosteron-system, indicators of activation of arginine vasopressin system) or the systemic impact (inflammation, oxidative stress…). In order to evaluate accurately the complex interactions that are the basis of cardiorenal syndromes, a multi-marker approach seems nowadays necessary.
authors.affiliation: Département de biochimie, CHU de Montpellier, Université de Montpellier I, France.
authors.forename: Nils
authors.initials: N
authors.lastname: Kuster
authors.forename: Marion
authors.initials: M
authors.lastname: Moréna
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Bargnoux
authors.forename: Hélène
authors.initials: H
authors.lastname: Leray
authors.forename: Leila
authors.initials: L
authors.lastname: Chenine
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Dupuy
authors.forename: Bernard
authors.initials: B
authors.lastname: Canaud
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis; D001127:Arginine Vasopressin / Q000032:analysis; D015415:Biomarkers / Q000032:analysis*; D059347:Cardio-Renal Syndrome / Q000175:diagnosis* / Q000628:therapy; D003404:Creatinine / Q000032:analysis; D055316:Cystatin C / Q000032:analysis; D050556:Fatty Acid-Binding Proteins / Q000032:analysis; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000032:analysis; D045265:Natriuretic Peptides / Q000032:analysis; D011518:Proto-Oncogene Proteins / Q000032:analysis; D012084:Renin-Angiotensin System / Q000502:physiology; D014336:Troponin / Q000032:analysis
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D050556:Fatty Acid-Binding Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D045265:Natriuretic Peptides; D011518:Proto-Oncogene Proteins; D014336:Troponin; D001127:Arginine Vasopressin; D003404:Creatinine
keywords: biomarker; cardiorenal syndrome; natriuretic peptides; neutrophil gelatinase-associated lipocalin; troponin