title: Cardiac injury after 10 gy total body irradiation: indirect role of effects on abdominal organs.
abstract: The objective of this study was to determine whether radiation-induced injury to the heart after 10 Gy total body irradiation (TBI) is direct or indirect. Young male WAG/RijCmcr rats received a 10 Gy single dose using TBI, upper hemi-body (UHB) irradiation, lower hemi-body (LHB) irradiation, TBI with the kidneys shielded or LHB irradiation with the intestines shielded. Age-matched, sham-irradiated rats served as controls. The lipid profile, kidney injury, heart and liver morphology and cardiac function were determined up to 120 days after irradiation. LHB, but not UHB irradiation, increased the risk factors for cardiac disease as well as the occurrence of cardiac and kidney injury in a way that was quantitatively and qualitatively similar to that observed after TBI. Shielding of the kidneys prevented the increases in risk factors for cardiac disease. Shielding of the intestines did not prevent the increases in risk factors for cardiac disease. There was no histological evidence of liver injury 120 days after irradiation. Injury to the heart from irradiation appears to be indirect, supporting the notion that injury to abdominal organs, principally the kidneys, is responsible for the increased risk factors for and the occurrence of cardiac disease after TBI and LHB irradiation.
authors.affiliation: a Division of Cardiothoracic Surgery, Departments of.
authors.forename: Marek
authors.initials: M
authors.lastname: Lenarczyk
authors.forename: Vy
authors.initials: V
authors.lastname: Lam
authors.forename: Eric
authors.initials: E
authors.lastname: Jensen
authors.forename: Brian L
authors.initials: BL
authors.lastname: Fish
authors.forename: Jidong
authors.initials: J
authors.lastname: Su
authors.forename: Stacy
authors.initials: S
authors.lastname: Koprowski
authors.forename: Richard A
authors.initials: RA
authors.lastname: Komorowski
authors.forename: Leanne
authors.initials: L
authors.lastname: Harmann
authors.forename: Raymond Q
authors.initials: RQ
authors.lastname: Migrino
authors.forename: X Allen
authors.initials: XA
authors.lastname: Li
authors.forename: John W
authors.initials: JW
authors.lastname: Hopewell
authors.forename: John E
authors.initials: JE
authors.lastname: Moulder
authors.forename: John E
authors.initials: JE
authors.lastname: Baker
mesh_terms: D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D006321:Heart / Q000528:radiation effects*; D007422:Intestines / Q000528:radiation effects; D007668:Kidney / Q000528:radiation effects; D008297:Male; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000209:etiology*; D051381:Rats; D012307:Risk Factors; D014916:Whole-Body Irradiation
chemical_list: D017931:DNA Primers
references.citation: Cardiovasc Ultrasound. 2008 Apr 29;6:17
references.pmid: 18445286
references.citation: J Am Soc Echocardiogr. 2007 Apr;20(4):342-51
references.pmid: 17400112
references.citation: Int J Radiat Oncol Biol Phys. 1992;23(3):681-6
references.pmid: 1612975
references.citation: Radiat Res. 2013 Jan;179(1):46-52
references.pmid: 23148507
references.citation: Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):170-81
references.pmid: 20056636
references.citation: Infect Immun. 2009 Jul;77(7):2741-53
references.pmid: 19380465
references.citation: Pediatr Transplant. 2012 Jun;16(4):385-91
references.pmid: 22471896
references.citation: Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):170-7
references.pmid: 18632215
references.citation: Int J Radiat Oncol Biol Phys. 1989 Jun;16(6):1501-9
references.pmid: 2656600
references.citation: Circulation. 2008 Feb 5;117(5):698-701
references.pmid: 18250280
references.citation: Am J Med. 2005 Nov;118(11):1287
references.pmid: 16271914
references.citation: Radiat Res. 2004 Mar;161(3):312-7
references.pmid: 14982483
references.citation: Radiat Res. 2012 Feb;177(2):220-8
references.pmid: 22149958
references.citation: BMJ. 2009 Dec 08;339:b4606
references.pmid: 19996459
references.citation: Ultrasound Med Biol. 2008 Feb;34(2):208-14
references.pmid: 17935867
references.citation: J Thromb Haemost. 2004 Nov;2(11):2027-35
references.pmid: 15550035
references.citation: Radiat Res. 2012 May;177(5):573-83
references.pmid: 22439602
references.citation: Cancer Biother Radiopharm. 2004 Jun;19(3):378-87
references.pmid: 15285886
references.citation: Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):656-65
references.pmid: 20159360
references.citation: Circ Res. 2011 Mar 4;108(5):619-28
references.pmid: 21372293
references.citation: Kidney Int. 2000 Aug;58(2):903-18
references.pmid: 10916120
references.citation: Radiat Res. 1993 Nov;136(2):205-13
references.pmid: 8248477
references.citation: Int J Radiat Biol. 2009 Dec;85(12):1089-100
references.pmid: 19995235
references.citation: Am J Physiol. 1956 Nov;187(2):378-80
references.pmid: 13372798
references.citation: Cancer Res. 2005 Apr 15;65(8):3100-7
references.pmid: 15833839
references.citation: Am J Cardiol. 2009 Oct 15;104(8):1023-9
references.pmid: 19801018
references.citation: Transl Res. 2007 Aug;150(2):106-15
references.pmid: 17656330
references.citation: Radiat Res. 2003 Jun;159(6):812-34
references.pmid: 12751965
references.citation: Radiat Res. 2004 Jun;161(6):622-32
references.pmid: 15161358
references.citation: Radiother Oncol. 1985 Jun;3(4):339-45
references.pmid: 4011953
references.citation: J Heart Lung Transplant. 2010 Sep;29(9):1039-46
references.pmid: 20488730
references.citation: Radiat Res. 2003 Oct;160(4):381-407
references.pmid: 12968934
references.citation: Science. 1952 May 16;115(2994):547-8
references.pmid: 17731965
references.citation: Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1415-8
references.pmid: 3759566
references.citation: N Engl J Med. 1970 Aug 13;283(7):374
references.pmid: 4988599