title: HepPar-1 expression in primary lung adenocarcinoma.
abstract: OBJECTIVE
  To study a subset of lung adenocarcinomas with aberrant HepPar-1 antigen expression.
  
  
  METHODS
  We performed a clinicopathologic review of 16 cases.
  
  
  RESULTS
  Of 241 primary lung adenocarcinomas tested for expression of the HepPar-1 antigen, 16 (6.6%) were positive. The cases occurred in older smokers with an equal sex distribution. Morphologically, these pulmonary adenocarcinomas had an acinar-predominant architecture, and prominent cribriform growth, with HepPar-1-expressing tumor cells being uniformly columnar with abundant bipolar lightly eosinophilic cytoplasm. HepPar-1 was coexpressed with thyroid transcription factor 1 in 94% of cases. No EGFR mutations were identified, while 31% of cases were positive for KRAS codon 12 mutations.
  
  
  CONCLUSIONS
  Although aberrant HepPar-1 expression was frequently seen in tumors with visceral pleural and angiolymphatic invasion, its prognostic significance is uncertain.
authors.affiliation: Department of Pathology, UPMC Presbyterian Shadyside, Presbyterian Campus-A610, 200 Lothrop St, Pittsburgh, PA 15213-2582, USA. yousemsa@upmc.edu
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Yousem
authors.forename: Seema
authors.initials: S
authors.lastname: Lale
authors.forename: Sanja
authors.initials: S
authors.lastname: Dacic
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms; D012189:Retrospective Studies; D018631:ras Proteins / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D066246:ErbB Receptors; D018631:ras Proteins
keywords: Adenocarcinoma; HepPar-1 antigen; Lung