title: Orbital Rosai-Dorfman disease: a literature review.
abstract: BACKGROUND
  Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder with a predilection for the head and neck. Isolated orbital involvement without systemic clinical features is very uncommon.
  
  
  BACKGROUND
  Classic histopathologic features include phagocytized but intact lymphocytes within large histiocytes; a conditioned termed emperipolesis. Immunohistochemical stains are strongly positive for S-100 and CD68 but negative for CD1a in most cases. Orbital cases are often amenable to complete surgical resection.
  
  
  CONCLUSIONS
  RDD should be considered in the differential diagnosis of a young patient in good health who presents with a marked but benign enlargement of an orbital mass. A review of the literature regarding this disease entity and its orbital manifestations is discussed.
authors.affiliation: Bayne-Jones Army Community Hospital, Ophthalmology Clinic, Fort Polk , Louisiana 71459 , USA and.
authors.forename: Scott F
authors.initials: SF
authors.lastname: McClellan
authors.forename: Darryl J
authors.initials: DJ
authors.lastname: Ainbinder
mesh_terms: D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D009916:Orbital Diseases / Q000175:diagnosis* / Q000628:therapy*