title: Prefrontal cortical microcircuits bind perception to executive control.
abstract: During the perception-to-action cycle, our cerebral cortex mediates the interactions between the environment and the perceptual-executive systems of the brain. At the top of the executive hierarchy, prefrontal cortical microcircuits are assumed to bind perceptual and executive control information to guide goal-driven behavior. Here, we tested this hypothesis by comparing simultaneously recorded neuron firing in prefrontal cortical layers and the caudate-putamen of rhesus monkeys, trained in a spatial-versus-object, rule-based match-to-sample task. We found that during the perception and executive selection phases, cell firing in the localized prefrontal layers and caudate-putamen region exhibited similar location preferences on spatial-trials, but less on object- trials. Then, we facilitated the perceptual-executive circuit by stimulating the prefrontal infra-granular-layers with patterns previously derived from supra-granular-layers, and produced stimulation-induced spatial preference in percent correct performance on spatial trials, similar to neural tuning. These results show that inter-laminar prefrontal microcircuits play causal roles to the perception-to-action cycle.
authors.affiliation: Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. ioopris@wfubmc.edu
authors.forename: Ioan
authors.initials: I
authors.lastname: Opris
authors.forename: Lucas
authors.initials: L
authors.lastname: Santos
authors.forename: Greg A
authors.initials: GA
authors.lastname: Gerhardt
authors.forename: Dong
authors.initials: D
authors.lastname: Song
authors.forename: Theodore W
authors.initials: TW
authors.lastname: Berger
authors.forename: Robert E
authors.initials: RE
authors.lastname: Hampson
authors.forename: Sam A
authors.initials: SA
authors.lastname: Deadwyler
mesh_terms: D000200:Action Potentials; D000818:Animals; D003198:Computer Simulation; D003210:Concept Formation / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology; D056344:Executive Function / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D010465:Perception; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology
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