title: [A case of neuromyelitis optica spectrum disorder developing a fulminant course with multiple white-matter lesions following fingolimod treatment].
abstract: A 49-year-old female neuromyelitis optica spectrum disorder (NMOSD) patient with positive anti-aquaporin 4 (AQP4) antibody was treated with fingolimod (FTY720). Ten days later, she developed acute disturbance of consciousness, aphasia, right hemi-spatial neglect, and right hemiparesis. Brain MRI showed multiple white-matter lesions with slight Gadolinium enhancement. She was diagnosed of acute exacerbation of NMOSD. Thus, fingolimod may be associated with the development of a fulminant course in NMOSD patients with positive anti-AQP4 antibody.
authors.affiliation: Department of Neurology, Saitama Medical Center.
authors.forename: Shoko
authors.initials: S
authors.lastname: Izaki
authors.forename: Shinya
authors.initials: S
authors.lastname: Narukawa
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kubota
authors.forename: Takao
authors.initials: T
authors.lastname: Mitsui
authors.forename: Hikoaki
authors.initials: H
authors.lastname: Fukaura
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Nomura
mesh_terms: D051401:Aquaporin 4 / Q000276:immunology; D001921:Brain / Q000473:pathology; D005260:Female; D000068876:Fingolimod Hydrochloride; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000139:chemically induced* / Q000473:pathology; D011409:Propylene Glycols / Q000009:adverse effects*; D013110:Sphingosine / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine