title: β-Cyclodextrin as the suitable molecular container for isopulegol enantiomers.
abstract: Isopulegol, an insoluble in water and highly volatile compound, due to its neuroactive properties is a potentially important agent for medical applications. Formation of "host-guest" molecular complexes with cyclodextrins would lead to the increase of its water solubility and bioavailability. Interactions between native cyclodextrins (α, β and γ) and isopulegol enantiomers were studied in solution proving the formation of inclusion complexes for β- and γ-cyclodextrins. For the more stable complexes with β-cyclodextrin crystal structures were obtained showing the formation of molecular capsules forming molecular container able to accommodate two guest molecules.
authors.affiliation: Institute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland. mceborska@ichf.edu.pl
authors.forename: Magdalena
authors.initials: M
authors.lastname: Ceborska
authors.forename: Kamila
authors.initials: K
authors.lastname: Szwed
authors.forename: Kinga
authors.initials: K
authors.lastname: Suwinska
mesh_terms: D000081005:Cyclohexane Monoterpenes; D019281:Dimerization; D006860:Hydrogen Bonding; D008958:Models, Molecular; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry*; D013816:Thermodynamics; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000081005:Cyclohexane Monoterpenes; D013729:Terpenes; D047392:beta-Cyclodextrins; C409816:isopulegol; C031215:betadex
keywords: Cyclodextrin; Highly volatile compounds; Inclusion complex; Molecular container