title: Evaluation of Albizia procera gum as compression coating material for colonic delivery of budesonide.
abstract: The purpose of this research was to develop and evaluate Albizia procera gum as compression-coating polymer for colonic delivery of budesonide. Tablets were prepared by direct compression method using spray-dried lactose and microcrystalline cellulose as filler binders. The compatibility between the drug and the polymer was studied through TGA and FTIR spectroscopy. In vitro drug release were studied in dissolution media with or without 2% rat cecal contents while in vivo X-ray study was conducted on rabbits. The results indicate that procera gum and the drug were compatible with each other and tablet coated with procera gum was suitable for colonic delivery of drugs.
authors.affiliation: Department of Pharmaceutical Sciences, Dibrugarh University, Assam, 786004, India.
authors.forename: Lalduhsanga
authors.initials: L
authors.lastname: Pachuau
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Mazumder
mesh_terms: D000285:Administration, Rectal; D031289:Albizzia / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D019819:Budesonide / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D008297:Male; D053149:Plant Gums / Q000737:chemistry*; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets / Q000008:administration & dosage / Q000737:chemistry; D013818:Thermogravimetry
chemical_list: D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D053149:Plant Gums; D013607:Tablets; D019819:Budesonide
keywords: Albizia procera gum; Colon targeting; Compression-coated tablets