title: Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder.
abstract: OBJECTIVE
  Autism spectrum disorder (ASD) is a brain-based pervasive developmental disorder, which-by growing consensus-is associated with abnormal organization of functional networks. Several previous studies of ASD have indicated atypical hemispheric asymmetries for language.
  
  
  OBJECTIVE
  To examine the asymmetry of functional networks using a data-driven approach for a comprehensive investigation of hemispheric asymmetry in ASD.
  
  
  METHODS
  This cross-sectional study involved 24 children with ASD and 26 matched typically developing children at San Diego State University and the University of California, San Diego. Data from 10 children had to be excluded for excessive motion, resulting in final samples of 20 participants per group.
  
  
  METHODS
  Asymmetry indices of functional networks identified from independent component analysis of resting-state functional magnetic resonance imaging data.
  
  
  RESULTS
  Temporal concatenation independent component analysis, performed separately in each group, showed significant group differences in asymmetry indices for 10 out of 17 functional networks. Without exception, these networks (visual, auditory, motor, executive, language, and attentional) showed atypical rightward asymmetry shifts in the ASD group.
  
  
  CONCLUSIONS
  Atypical rightward asymmetry may be a pervasive feature of functional brain organization in ASD, affecting sensorimotor, as well as higher cognitive, domains.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Cardinale
authors.forename: Patricia
authors.initials: P
authors.lastname: Shih
authors.forename: Inna
authors.initials: I
authors.lastname: Fishman
authors.forename: Leanne M
authors.initials: LM
authors.lastname: Ford
authors.forename: Ralph-Axel
authors.initials: RA
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D025341:Principal Component Analysis
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