title: Association between the Pro12Ala polymorphism of PPAR-γ gene and the non-alcoholic fatty liver disease: a meta-analysis.
abstract: Several studies have been conducted to examine the association between PPAR-γ2 Pro12Ala polymorphism and non-alcoholic fatty liver disease (NAFLD), but the results remain inconsistent. In this study, a meta-analysis was performed to assess the association of PPAR-γ Pro12Ala polymorphism with NAFLD risk. A total of 8 case-control studies, including 1697 cases and 2427 controls, were selected. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. Overall, no evidence has indicated that the Pro12Ala polymorphism was associated with the susceptibility to NAFLD. Besides, stratified analysis with ethnicity also indicated that no significant association between PPAR-γ Pro12Ala and the risk of NAFLD under all for genetic model in both Asian and Caucasian populations was observed. This meta-analysis indicated that the Pro12Ala polymorphism is not associated with NAFLD risk. Large and well-designed studies are warranted to validate our findings.
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Xufeng
authors.initials: X
authors.lastname: Guo
authors.forename: Pengbo
authors.initials: P
authors.lastname: Wu
authors.forename: Jia
authors.initials: J
authors.lastname: Song
authors.forename: Chuncui
authors.initials: C
authors.lastname: Ye
authors.forename: Shijie
authors.initials: S
authors.lastname: Yu
authors.forename: Jixiang
authors.initials: J
authors.lastname: Zhang
authors.forename: Weiguo
authors.initials: W
authors.lastname: Dong
mesh_terms: D019943:Amino Acid Substitution; D016022:Case-Control Studies; D005234:Fatty Liver / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease; D016017:Odds Ratio; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D047495:PPAR gamma
keywords: CI; HWE; Hardy–Weinberg equilibrium; MS; Meta-analysis; NAFLD; NASH; Non-alcoholic fatty liver disease; OR; PPAR-γ; Polymorphism; SNP; confidence interval; metabolic syndrome; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; odds ratio; peroxisome proliferator activated receptor-γ; single nucleotide polymorphism