title: Early diagnosis and treatment of obstructive sleep apnea after stroke: Are we neglecting a modifiable stroke risk factor?
abstract: Sleep-disordered breathing is an increasingly recognized disorder that is particularly prevalent among stroke patients. Obstructive sleep apnea, a form of sleep-disordered breathing, is associated with multiple major stroke risk factors but is also an independent risk factor for stroke. In addition, untreated sleep apnea is associated with poor functional outcome after stroke. Sleep apnea is amenable to treatment and should be considered a modifiable stroke risk factor, though long-term compliance remains a major barrier. A better understanding of the relationship between sleep apnea and stroke may prompt providers to pursue the early diagnosis and treatment of underlying sleep-disordered breathing to both improve the chance of recovery from stroke in the short term and to reduce the risk of recurrent stroke in the long term.
authors.affiliation: Department of Neurology, Harborview Medical Center, University of Washington, Seattle.
authors.forename: Arielle P
authors.initials: AP
authors.lastname: Davis
authors.forename: Martha E
authors.initials: ME
authors.lastname: Billings
authors.forename: W T
authors.initials: WT
authors.lastname: Longstreth
authors.forename: Sandeep P
authors.initials: SP
authors.lastname: Khot
references.citation: Sleep Breath. 2006 Mar;10(1):43-50
references.pmid: 16491391
references.citation: Am J Respir Crit Care Med. 2001 Jan;163(1):19-25
references.pmid: 11208620
references.citation: Am J Respir Crit Care Med. 2006 Apr 15;173(8):910-6
references.pmid: 16424443
references.citation: Stroke. 1996 Feb;27(2):252-9
references.pmid: 8571419
references.citation: JAMA. 2000 Apr 12;283(14):1829-36
references.pmid: 10770144
references.citation: Stroke. 2011 Jan;42(1):227-76
references.pmid: 20966421
references.citation: N Engl J Med. 2005 Nov 10;353(19):2034-41
references.pmid: 16282178
references.citation: Am J Respir Crit Care Med. 2010 Jul 15;182(2):269-77
references.pmid: 20339144
references.citation: Semin Neurol. 2006 Feb;26(1):117-22
references.pmid: 16479450
references.citation: Sleep. 2003 May 1;26(3):293-7
references.pmid: 12749548
references.citation: Neurology. 2009 Oct 20;73(16):1313-22
references.pmid: 19841384
references.citation: Lancet Neurol. 2004 Jun;3(6):333-42
references.pmid: 15157848
references.citation: Lancet. 2005 Mar 19-25;365(9464):1046-53
references.pmid: 15781100
references.citation: Arch Intern Med. 2008 Feb 11;168(3):297-301
references.pmid: 18268171
references.citation: WMJ. 2009 Aug;108(5):246-9
references.pmid: 19743755
references.citation: Sleep Med. 2009 Aug;10(7):717-9
references.pmid: 19168390
references.citation: Stroke. 2012 Apr;43(4):1143-5
references.pmid: 22156693
references.citation: Stroke. 2006 Apr;37(4):967-72
references.pmid: 16543515
references.citation: Am J Epidemiol. 2004 Sep 15;160(6):521-30
references.pmid: 15353412
references.citation: N Engl J Med. 2000 May 11;342(19):1378-84
references.pmid: 10805822