title: Effect of axial length on retinal nerve fiber layer thickness in children.
abstract: OBJECTIVE
  To investigate the effect of axial length on peripapillary retinal nerve fiber layer (RNFL) thickness in myopic, hyperopic, and emmetropic eyes in children by Cirrus HD spectral-domain optical coherence tomography (OCT).
  
  
  METHODS
  Subjects were divided into 3 groups according to their refractive status: myopic (n = 36), emmetropic (n = 30), and hyperopic (n = 28) eyes. The RNFL thickness measurements were taken from the superior, inferior, nasal, and temporal quadrants in the peripapillary region by Cirrus HD OCT. Axial length was also determined for each patient.
  
  
  RESULTS
  The myopic eyes had thinner average RNFL and RNFLs of temporal, superior, nasal, and inferior quadrants than the hyperopic eyes (p1<0.001, p2 = 0.004, p3 = 0.011, p4 = 0.006, p5 = 0.033, respectively). In addition, average peripapillary RNFL thickness and RNFL thicknesses of all quadrants had significant negative correlations with axial length. On the other hand, after applying modified Littmann formula for correction of magnification effect, the differences among the 3 groups disappeared (all p>0.05).
  
  
  CONCLUSIONS
  We have shown that axial length and accordingly refractive status influenced peripapillary RNFL thickness measurements by Cirrus HD OCT in children. Therefore, to make a correct diagnosis of glaucoma or other optic neuropathies in children, either axial length-induced magnification effect should be corrected by ophthalmologists or the current Cirrus HD OCT database should be revised taking axial length into consideration.
authors.affiliation: Department of Ophthalmology, Recep Tayyip Erdogan University Medical School, Rize - Turkey.
authors.forename: Veysi
authors.initials: V
authors.lastname: Öner
authors.forename: Gökhan
authors.initials: G
authors.lastname: Özgür
authors.forename: Kemal
authors.initials: K
authors.lastname: Türkyilmaz
authors.forename: Berrak
authors.initials: B
authors.lastname: Şekeryapan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Durmus
mesh_terms: D000293:Adolescent; D058452:Axial Length, Eye / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D058453:Emmetropia / Q000502:physiology; D005260:Female; D006801:Humans; D006956:Hyperopia / Q000503:physiopathology*; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D009216:Myopia / Q000503:physiopathology*; D009412:Nerve Fibers / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology