title: Registry of gastric cancer treatment evaluation (REGATE): II treatment practice.
abstract: OBJECTIVE
  The objective of the registry of gastric cancer treatment evaluation (REGATE) study was to evaluate approaches to gastric cancer treatment in different geographical regions.
  
  
  METHODS
  REGATE enrolled patients with newly diagnosed gastric cancer at any stage of the disease from the Asia-Pacific region, Europe, the Indian subcontinent, Latin America and North Africa between 2004 and 2008.
  
  
  RESULTS
  Among 9965 patients, 69% received surgery, 40% palliative care, 29% adjuvant therapy and 2% neoadjuvant therapy; 15% received no treatment. Combination treatment (mostly surgery/adjuvant) was used in one-third of patients. Overall, 90% received chemotherapy (mostly fluoropyrimidine/platinum combinations but with marked geographical variation) and 21% received radiotherapy. Curative surgery alone was used most frequently for stages 0-II cancers and was employed more often in Europe (55%) and the Asia-Pacific (48%) than in other regions (27-35%). Asia-Pacific and Indian subcontinent patients were more likely to have a distal subtotal gastrectomy and less likely to undergo total gastrectomy than patients in other regions. Lymph node D2 dissection was favored in the Asia-Pacific, Europe and Latin America, whereas D1 dissection was used more in the Indian subcontinent and North Africa.
  
  
  CONCLUSIONS
  These data showing geographical differences in the approaches to gastric cancer treatment may promote the optimization of the management of gastric cancer globally.
authors.affiliation: Thoraco-abdominal Oncosurgical Department, Clinical Hospital of the President Administration, Moscow, Russia.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Ter-Ovanesov
authors.forename: Suayib
authors.initials: S
authors.lastname: Yalcin
authors.forename: John
authors.initials: J
authors.lastname: Zalcberg
authors.forename: Simon
authors.initials: S
authors.lastname: Hitier
authors.forename: Yung-Jue
authors.initials: YJ
authors.lastname: Bang
authors.forename: Chew-Wun
authors.initials: CW
authors.lastname: Wu
authors.forename: Arnaud
authors.initials: A
authors.lastname: Roth
mesh_terms: D017024:Chemotherapy, Adjuvant / Q000706:statistics & numerical data; D003625:Data Collection; D005260:Female; D005743:Gastrectomy / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D010166:Palliative Care / Q000379:methods / Q000706:statistics & numerical data; D012042:Registries; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*
keywords: adjuvant chemotherapy; data collection; drug therapy; gastrectomy; palliative care; stomach neoplasm