title: Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172.
abstract: The development of a practical, asymmetric synthesis of the hepatitis C virus (HCV) protease inhibitor MK-5172 (1), an 18-membered macrocycle, is described.
authors.affiliation: Process Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065-0200, USA. Jeffrey_kuethe@merck.com
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kuethe
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Zhong
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Yasuda
authors.forename: Gregory
authors.initials: G
authors.lastname: Beutner
authors.forename: Katherine
authors.initials: K
authors.lastname: Linn
authors.forename: Mary
authors.initials: M
authors.lastname: Kim
authors.forename: Benjamin
authors.initials: B
authors.lastname: Marcune
authors.forename: Spencer Douglas
authors.initials: SD
authors.lastname: Dreher
authors.forename: Guy
authors.initials: G
authors.lastname: Humphrey
authors.forename: Tao
authors.initials: T
authors.lastname: Pei
mesh_terms: D000577:Amides; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002219:Carbamates; D003521:Cyclopropanes; D016174:Hepacivirus / Q000187:drug effects*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013449:Sulfonamides; D047029:Lactams, Macrocyclic
chemical_list: D000577:Amides; D000998:Antiviral Agents; D002219:Carbamates; D003521:Cyclopropanes; D047028:Macrocyclic Compounds; D011480:Protease Inhibitors; D011810:Quinoxalines; D013449:Sulfonamides; C578009:grazoprevir; D047029:Lactams, Macrocyclic