title: Lactobacillus plantarum TN8 exhibits protective effects on lipid, hepatic and renal profiles in obese rat.
abstract: This study aimed to first investigate the immuno-modulatory effects of six newly isolated lactic acid bacteria (LAB) on the peripheral blood mononuclear cells (PBMC) of Wistar rats. Except for Lactobacillus plantarum TN8, all the other strains were noted to induce high levels of pro-inflammatory cytokine IL-12 and low levels of anti-inflammatory cytokine IL-10. The strains also generated low ratios of IL-10/IL-12 cytokine. Strain TN8 was, on the other hand, noted to induce an increase in anti-inflammatory IL-10 cytokine secretion rates and a decrease in pro-inflammatory IL-12, IFN-γ and TNF-α cytokine production. The oral administration of TN8 improved the hepatic and urinary functions of obese rats by inducing decreases (P < 0.05) in alanine amino transferase (ALAT), gamma glutamyl transferase (GGT), plasmatic triglycerides, total cholesterol concentrations, creatinine, urea, and body weight when compared to the control group of animals that underwent an increase in aspartate amino transferase (ASAT) and high density lipoprotein (HDL). Overall, the findings indicate that strain TN8 exhibited a number of attractive properties that might open new promising opportunities for the improvement of various parameters related to animal health performance and the avoidance of antibiotics and drugs as promoting factors.
authors.affiliation: Laboratory of Microorganisms and Biomolecules (LMB), Centre of Biotechnology of Sfax, Road of Sidi Mansour Km 6, P.O. Box 1177, Sfax 3018, Tunisia. Electronic address: riadh_fss@yahoo.fr.
authors.forename: Riadh
authors.initials: R
authors.lastname: Ben Salah
authors.forename: Imen
authors.initials: I
authors.lastname: Trabelsi
authors.forename: Khaled
authors.initials: K
authors.lastname: Hamden
authors.forename: Hichem
authors.initials: H
authors.lastname: Chouayekh
authors.forename: Samir
authors.initials: S
authors.lastname: Bejar
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D048191:Lactiplantibacillus plantarum / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000502:physiology*; D008111:Liver Function Tests; D008297:Male; D009765:Obesity / Q000628:therapy*; D019936:Probiotics / Q000008:administration & dosage* / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D008055:Lipids
keywords: Blood; Cytokines; Kidney; Lactic acid bacteria; Liver; Obesity