title: Pharmacology of TRP channels in the vasculature.
abstract: The TRP family of cation-permeable channels owes its name to a Drosophila TRP mutant with impaired vision due to transient rather than sustained receptor potential. Mammalian TRP channels can be grouped into 6 subfamilies, including TRPC, TRPM, TRPV, TRPA, TRPP and TRPML and a number of TRP family members have been identified in the vasculature. TRP channels play an important functional role in the vasculature as mediators of cation influx across the plasma membrane, thus contributing to a large number of processes such as vascular smooth muscle contraction and vascular pressure or the responses to oxidative stress, mechanical stimuli, heat and hypoxia-induced vascular remodelling. TRP channelopaties are involved in the pathogenesis of different disorders including hypertension and cardiomyopathy. A number of identified natural compounds and synthetic agents have been reported to modulate TRP function, and are the base for therapeutical strategies.
authors.affiliation: Department of Physiology, Cell Physiology Research Group, University of Extremadura, 10003, Cáceres, Spain.
authors.forename: Isaac
authors.initials: I
authors.lastname: Jardín
authors.forename: Natalia
authors.initials: N
authors.lastname: Dionisio
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Lopez
authors.forename: Gines M
authors.initials: GM
authors.lastname: Salido
authors.forename: Juan A
authors.initials: JA
authors.lastname: Rosado
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000503:physiopathology; D002462:Cell Membrane / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D058990:Molecular Targeted Therapy; D009119:Muscle Contraction / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D018384:Oxidative Stress; D050051:Transient Receptor Potential Channels / Q000187:drug effects / Q000378:metabolism*
chemical_list: D050051:Transient Receptor Potential Channels