title: Virulence, genomic features, and plasticity of Aeromonas salmonicida subsp. salmonicida, the causative agent of fish furunculosis.
abstract: The bacterium Aeromonas salmonicida subsp. salmonicida is the causative agent of furunculosis, a systemic disease of fish in the salmonid family. Furunculosis is a ubiquitous disease that affects aquaculture operations worldwide and is characterized by high mortality and morbidity. A better understanding of the bacterium is required to find a cure. Thereby, this review centers on A. salmonicida subsp. salmonicida, its major virulence factors, and its genome. The classification and characteristics of A. salmonicida subsp. salmonicida, the virulence factors, such as the A-layer, extracellular molecules, and type three secretion system as well as the characteristics and plasticity of its genome are described.
authors.affiliation: Institut de biologie intégrative et des systèmes, Pavillon Charles-Eugène-Marchand, Université Laval, 1030 avenue de la Médecine, Quebec City, QC, Canada G1V 0A6; Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Hôpital Laval), 2725 Chemin Sainte-Foy, Quebec City, QC, Canada G1V 4G5.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Dallaire-Dufresne
authors.affiliation: Institut de biologie intégrative et des systèmes, Pavillon Charles-Eugène-Marchand, Université Laval, 1030 avenue de la Médecine, Quebec City, QC, Canada G1V 0A6; Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Hôpital Laval), 2725 Chemin Sainte-Foy, Quebec City, QC, Canada G1V 4G5.
authors.forename: Katherine H
authors.initials: KH
authors.lastname: Tanaka
authors.affiliation: Institut de biologie intégrative et des systèmes, Pavillon Charles-Eugène-Marchand, Université Laval, 1030 avenue de la Médecine, Quebec City, QC, Canada G1V 0A6; Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Hôpital Laval), 2725 Chemin Sainte-Foy, Quebec City, QC, Canada G1V 4G5.
authors.forename: Mélanie V
authors.initials: MV
authors.lastname: Trudel
authors.affiliation: Faculté de Médecine Vétérinaire, Université de Montréal, 3200 rue Sicotte, St-Hyacinthe, QC, Canada J2S 7C6.
authors.forename: Andrée
authors.initials: A
authors.lastname: Lafaille
authors.affiliation: Institut de biologie intégrative et des systèmes, Pavillon Charles-Eugène-Marchand, Université Laval, 1030 avenue de la Médecine, Quebec City, QC, Canada G1V 0A6; Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Hôpital Laval), 2725 Chemin Sainte-Foy, Quebec City, QC, Canada G1V 4G5; Département de biochimie, de microbiologie et de bio-informatique, Faculté des sciences et de génie, Université Laval, 1045 avenue de la Médecine, Quebec City, QC, Canada G1V 0A6. Electronic address: steve.charette@bcm.ulaval.ca.
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Charette
mesh_terms: D048409:Aeromonas salmonicida / Q000235:genetics* / Q000472:pathogenicity* / Q000502:physiology; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D058947:Bacterial Secretion Systems / Q000502:physiology; D005393:Fish Diseases / Q000382:microbiology*; D005667:Furunculosis / Q000382:microbiology / Q000662:veterinary*; D016680:Genome, Bacterial; D012487:Salmonidae / Q000382:microbiology*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D037521:Virulence Factors
keywords: Aeromonas salmonicida; Antibiotic resistance; Furunculosis; Genome; Insertion sequences; Plasmid; Type three secretion system; Virulence