title: Two different hypofractionated breast radiotherapy schedules for 113 patients with ductal carcinoma in situ: preliminary results.
abstract: OBJECTIVE
  To assess local control and cosmetic outcomes for two different hypofractionated radiotherapy schedules after breast-conserving surgery for ductal carcinoma in situ (DCIS).
  
  
  METHODS
  A total of 113 breast-conserving operated patients with DCIS were treated from August 2006 to August 2011: 41 women received 46 Gy in 20 fractions of 2.3 Gy four times a week, for five weeks; the other 72 patients received 39 Gy in 13 fractions of 3 Gy four times a week for 3.5 weeks. Both schedules involved a concomitant boost to the tumor bed, with dose adjustment according to the surgical margins.
  
  
  RESULTS
  The median follow-up is 30.5 months. Overall, the treatments were well-tolerated. The most common acute effect was erythema: grade 1 in 56.1% and 31.9% in the longer and in the shorter hypofractionated treatment, grade 2 in 9.8% and 0% of cases respectively. Late toxicity of fibrosis occurred at grade 1 in 19.6% and 15.3% respectively and at grade 2 in 0% and 2.8%.
  
  
  CONCLUSIONS
  These results suggest that patients with DCIS can be safely treated with a shorter radiotherapy regimen.
authors.affiliation: Oncologia Radioterapica, IRCCS A.O.U. San Martino-IST-Istituto Nazionale per la Ricerca, sul Cancro, Largo R. Benzi, 10, 16132 Genoa, Italy. ale.fozza@libero.it
authors.forename: Marina
authors.initials: M
authors.lastname: Guenzi
authors.forename: Flavio
authors.initials: F
authors.lastname: Giannelli
authors.forename: Davide
authors.initials: D
authors.lastname: Bosetti
authors.forename: Gladys
authors.initials: G
authors.lastname: Blandino
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Milanese
authors.forename: Francesco
authors.initials: F
authors.lastname: Pupillo
authors.forename: Renzo
authors.initials: R
authors.lastname: Corvò
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fozza
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000532:radiotherapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000532:radiotherapy*; D003357:Cosmetic Techniques; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008875:Middle Aged
keywords: Breast cancer; ductal carcinoma in situ; hypofractionated radiotherapy