title: Fatal herpes encephalitis in a patient with small cell lung cancer following prophylactic cranial radiation--a case report with review of literature.
abstract: Herpes simplex virus 1 (HSV-1) is the principal cause of viral necrotizing encephalitis in developed countries. Small cell carcinoma of the lung accounts for about 15% of all lung cancer. HSV induced encephalitis (HSE) following prophylactic cranial irradiation (PCI) in SCLC is rare. Here, we describe the case of a 58-year-old woman with limited stage SCLC, multiple sclerosis (MS) and cutaneous lupus who developed fatal HSE following PCI. We review the literature to investigate the inter-relationships between these diseases and management of HSE.
authors.affiliation: Department of Internal Medicine, University of Nebraska Medical Center, Omaha. NE 68198-2055, USA. schakra@unmc.edu
authors.forename: Subhankar
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Michael
authors.initials: M
authors.lastname: Donner
authors.forename: David
authors.initials: D
authors.lastname: Colan
mesh_terms: D001921:Brain / Q000473:pathology; D016371:Cranial Irradiation / Q000009:adverse effects*; D020803:Encephalitis, Herpes Simplex / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000517:prevention & control / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D055752:Small Cell Lung Carcinoma / Q000150:complications* / Q000517:prevention & control / Q000532:radiotherapy*
keywords: Herpes simplex virus-1; encephalitis; immunosuppression; radiation; small cell lung cancer