title: Comparison of current recommended regimens of atropinization in organophosphate poisoning.
abstract: Atropine is the mainstay of therapy in organophosphate (OP) toxicity, though research and consensus on dosing is lacking. In 2004, as reported by Eddleston et al. (J Toxicol Clin Toxicol 42(6):865-75, 2004), they noted variation in recommended regimens. We assessed revisions of original references, additional citations, and electronic sources to determine the current variability in atropine dosing recommendations. Updated editions of references from Eddleston et al.'s work, texts of Internal and Emergency Medicine, and electronic resources were reviewed for atropine dosing recommendations. For comparison, recommendations were assessed using the same mean dose (23.4 mg) and the highest dose (75 mg) of atropine as used in the original paper. Recommendations were also compared with the dosing regimen from the World Health Organization (WHO). Thirteen of the original recommendations were updated and 15 additional references were added giving a convenience sample of 28. Sufficient information to calculate time to targeted dose was provided by 24 of these samples. Compared to 2004, current recommendations have greatly increased the speed of atropinization with 13/24 able to reach the mean and high atropine dose within 30 min compared to 1/36 in 2004. In 2004, there were 13 regimens where the maximum time to reach 75 mg was over 18 h, whereas now, there are 2. While only one recommendation called for doubling the dose for faster escalation in 2004, 15 of the 24 current works include dose doubling. In 2004, Eddleston et al. called for an evidence-based guideline for the treatment of OP poisoning that could be disseminated worldwide. Many current recommendations can adequately treat patients within 1 h. While the WHO recommendations remain slow to treat patients with OP poisoning, other authorities are close to a consensus on rapid atropinization.
authors.affiliation: NYU/Bellevue Hospital Center, 455 First Ave, New York, NY, USA, Nicholas.Connors@nyumc.org.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Connors
authors.forename: Zachary H
authors.initials: ZH
authors.lastname: Harnett
authors.forename: Robert S
authors.initials: RS
authors.lastname: Hoffman
mesh_terms: D000931:Antidotes / Q000008:administration & dosage* / Q000627:therapeutic use; D001285:Atropine / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D062025:Organophosphate Poisoning / Q000188:drug therapy*; D017410:Practice Guidelines as Topic
chemical_list: D000931:Antidotes; D001285:Atropine
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