title: Cancer immunotherapy with exosomes requires B-cell activation.
abstract: Exosomes derived from dendritic cells (dexosomes) induce potent antitumor immune responses in mice. We have shown that the efficacy of dexosome-elicited antitumor immunity relies on the presence of both T- and B-cell dexosome-associated epitopes. Hence, the inclusion of B-cell epitopes in anticancer vaccines is crucial for the success of this immunotherapeutic intervention.
authors.affiliation: Karolinska Institutet; Department of Medicine; Translational Immunology Unit L2:04; Karolinska University Hospital Solna; Stockholm, Sweden.
authors.forename: Tanja I
authors.initials: TI
authors.lastname: Näslund
authors.forename: Ulf
authors.initials: U
authors.lastname: Gehrmann
authors.forename: Susanne
authors.initials: S
authors.lastname: Gabrielsson
keywords: B cells; CD4+ T cells; CD8+ T cells; dexosomes; exosomes; marginal zone B cells; melanoma
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