title: Biodegradability engineering of biodegradable Mg alloys: tailoring the electrochemical properties and microstructure of constituent phases.
abstract: Crystalline Mg-based alloys with a distinct reduction in hydrogen evolution were prepared through both electrochemical and microstructural engineering of the constituent phases. The addition of Zn to Mg-Ca alloy modified the corrosion potentials of two constituent phases (Mg + Mg2Ca), which prevented the formation of a galvanic circuit and achieved a comparable corrosion rate to high purity Mg. Furthermore, effective grain refinement induced by the extrusion allowed the achievement of much lower corrosion rate than high purity Mg. Animal studies confirmed the large reduction in hydrogen evolution and revealed good tissue compatibility with increased bone deposition around the newly developed Mg alloy implants. Thus, high strength Mg-Ca-Zn alloys with medically acceptable corrosion rate were developed and showed great potential for use in a new generation of biodegradable implants.
authors.affiliation: School of Advanced Materials Engineering, Kookmin University, Seoul, South Korea.
authors.forename: Pil-Ryung
authors.initials: PR
authors.lastname: Cha
authors.forename: Hyung-Seop
authors.initials: HS
authors.lastname: Han
authors.forename: Gui-Fu
authors.initials: GF
authors.lastname: Yang
authors.forename: Yu-Chan
authors.initials: YC
authors.lastname: Kim
authors.forename: Ki-Ha
authors.initials: KH
authors.lastname: Hong
authors.forename: Seung-Cheol
authors.initials: SC
authors.lastname: Lee
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Jung
authors.forename: Jae-Pyeong
authors.initials: JP
authors.lastname: Ahn
authors.forename: Young-Yul
authors.initials: YY
authors.lastname: Kim
authors.forename: Sung-Youn
authors.initials: SY
authors.lastname: Cho
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Byun
authors.forename: Kang-Sik
authors.initials: KS
authors.lastname: Lee
authors.forename: Seok-Jo
authors.initials: SJ
authors.lastname: Yang
authors.forename: Hyun-Kwang
authors.initials: HK
authors.lastname: Seok
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D003343:Corrosion; D004553:Electric Conductivity; D019544:Equipment Failure Analysis; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D044367:Phase Transition; D011474:Prosthesis Design; D013499:Surface Properties
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D008274:Magnesium
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