title: Acquired Fanconi syndrome in patients with Legionella pneumonia.
abstract: BACKGROUND
  Hyponatremia is often observed in patients with Legionella pneumonia. However, other electrolyte abnormalities are uncommon and the mechanism remains to be clarified.
  
  
  METHODS
  We experienced two male cases of acquired Fanconi syndrome associated with Legionella pneumonia. The laboratory findings at admission showed hypophosphatemia, hypokalemia, hypouricemia and/or hyponatremia. In addition, they had the generalized dysfunction of the renal proximal tubules presenting decreased tubular reabsorption of phosphate (%TRP), increased fractional excretion of potassium (FEK) and uric acid (FEUA), low-molecular-weight proteinuria, panaminoaciduria and glycosuria. Therefore, they were diagnosed as Fanconi syndrome. Treatment for Legionella pneumonia with antibiotics resulted in the improvement of all serum electrolyte abnormalities and normalization of the %TRP, FEK, FEUA, low-molecular-weight proteinuria, panaminoaciduria and glycosuria, suggesting that Legionella pneumophila infection contributed to the pathophysiology of Fanconi syndrome.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first report demonstrating Fanconi syndrome associated with Legionella pneumonia.
authors.affiliation: Renal Division, Department of Internal Medicine, Iwata City Hospital, 512-3 Ohkubo, Iwata, Shizuoka, 438-8550, Japan. knstnk1984@yahoo.co.jp
authors.forename: Naoko
authors.initials: N
authors.lastname: Kinoshita-Katahashi
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Fukasawa
authors.forename: Sayaka
authors.initials: S
authors.lastname: Ishigaki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Isobe
authors.forename: Shiro
authors.initials: S
authors.lastname: Imokawa
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujigaki
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Furuya
mesh_terms: D000368:Aged; D005198:Fanconi Syndrome / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007875:Legionella; D007877:Legionnaires' Disease / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged
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