title: Accelerated Aging in HIV Patients.
abstract: Life expectancy has been increasing in the last few decades in the Western world and is accompanied by higher occurrence of age-related diseases like metabolic, cardiovascular, and renal diseases and also with a decline in immune functions. In HIV-infected people, due to the use of combination antiretroviral therapy (cART), life expectancy has increased. As a result, non-AIDS conditions which are age-associated have become more prevalent and appear earlier, resulting in accelerated aging in HIV patients. These non-AIDS conditions in HIV patients are associated with CD4+ T cell counts: lower counts are associated with higher rates of liver, cardiovascular, renal, and neurocognitive disorders. The effect of viral load and cART on the earlier occurrence of age-associated diseases is less significant than the CD4 count effect. Thus, the loss of immune functions in HIV-infected patients may enhance aging.
authors.affiliation: Institute for Allergy, Immunology & AIDS, Rambam Health Care Campus, Haifa, Israel, and the.
authors.forename: Keren
authors.initials: K
authors.lastname: Meir-Shafrir
authors.forename: Shimon
authors.initials: S
authors.lastname: Pollack
keywords: AIDS; Aging; HIV; immune senescence
references.citation: AIDS. 2000 May 5;14(7):771-80
references.pmid: 10839584
references.citation: N Engl J Med. 2007 Apr 26;356(17):1723-35
references.pmid: 17460226
references.citation: J Neurovirol. 2012 Aug;18(4):247-55
references.pmid: 22205585
references.citation: AIDS. 2010 Jun 1;24(9):1243-50
references.pmid: 19996937
references.citation: J Infect Dis. 2003 Jun 15;187(12):1924-33
references.pmid: 12792869
references.citation: Ann Intern Med. 2007 Jan 16;146(2):87-95
references.pmid: 17227932
references.citation: Curr Infect Dis Rep. 2009 Nov;11(6):479-85
references.pmid: 19857388
references.citation: AIDS. 2012 Apr 24;26(7):843-53
references.pmid: 22313961
references.citation: Clin Endocrinol (Oxf). 2007 Aug;67(2):270-5
references.pmid: 17547686
references.citation: J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1279-86
references.pmid: 18000149
references.citation: AIDS. 2009 Jun 1;23(9):1059-67
references.pmid: 19390417
references.citation: AIDS. 1998 May 7;12(7):F51-8
references.pmid: 9619798
references.citation: J Neurovirol. 2011 Feb;17(1):3-16
references.pmid: 21174240
references.citation: Am J Kidney Dis. 2010 Nov;56(5):872-82
references.pmid: 20709438
references.citation: J Infect Dis. 2008 Jan 1;197(1):126-33
references.pmid: 18171295
references.citation: Semin Immunol. 2012 Oct;24(5):342-9
references.pmid: 22560930
references.citation: J Am Geriatr Soc. 2012 Mar;60(3):545-9
references.pmid: 22315957
references.citation: J Acquir Immune Defic Syndr. 2009 Jul 1;51(3):298-304
references.pmid: 19412117
references.citation: AIDS. 2010 Jan 16;24(2):243-53
references.pmid: 19996940
references.citation: J Clin Endocrinol Metab. 2006 Aug;91(8):2938-45
references.pmid: 16735489
references.citation: Clin Infect Dis. 2008 Aug 15;47(4):542-53
references.pmid: 18627268
references.citation: Clin Infect Dis. 2001 Jan;32(1):130-9
references.pmid: 11118392
references.citation: PLoS One. 2011 Jan 26;6(1):e16459
references.pmid: 21298072
references.citation: Clin Trials. 2013;10(1 Suppl):S5-S36
references.pmid: 22547421
references.citation: J Clin Endocrinol Metab. 2008 Sep;93(9):3499-504
references.pmid: 18593764
references.citation: Clin Infect Dis. 2005 Jun 15;40(12):1837-45
references.pmid: 15909274
references.citation: J Biol Chem. 2003 Nov 28;278(48):48251-8
references.pmid: 12975380
references.citation: Clin Infect Dis. 2011 Dec;53(11):1120-6
references.pmid: 21998278
references.citation: N Engl J Med. 2006 Nov 30;355(22):2283-96
references.pmid: 17135583
references.citation: AIDS. 2009 Mar 27;23(6):689-96
references.pmid: 19262355
references.citation: J Biol Chem. 2000 Jul 7;275(27):20251-4
references.pmid: 10806189
references.citation: J Acquir Immune Defic Syndr. 2005 Oct 1;40(2):121-31
references.pmid: 16186728
references.citation: Biogerontology. 2010 Oct;11(5):603-14
references.pmid: 20549351
references.citation: J Gerontol A Biol Sci Med Sci. 2002 May;57(5):M283-8
references.pmid: 11983721
references.citation: Immunol Lett. 2005 Feb 15;97(1):19-29
references.pmid: 15626472
references.citation: J Neurosci Res. 2003 Oct 15;74(2):296-308
references.pmid: 14515359
references.citation: Curr Atheroscler Rep. 2008 Feb;10(1):61-70
references.pmid: 18366987
references.citation: Am J Med. 2007 Sep;120(9):748-53
references.pmid: 17765039
references.citation: J Infect Dis. 2010 Jun 15;201(12):1788-95
references.pmid: 20446848
references.citation: J Acquir Immune Defic Syndr. 2007 Nov 1;46(3):283-90
references.pmid: 18167644
references.citation: J Clin Invest. 2000 Dec;106(12):1481-8
references.pmid: 11120755
references.citation: AIDS. 2010 Jul 17;24(11):1667-78
references.pmid: 20523203
references.citation: J Clin Endocrinol Metab. 2007 Jul;92(7):2506-12
references.pmid: 17456578
references.citation: J Acquir Immune Defic Syndr. 2006 Aug 15;42(5):562-71
references.pmid: 16837863
references.citation: J Acquir Immune Defic Syndr. 2009 Aug 15;51(5):554-61
references.pmid: 19512937
references.citation: AIDS. 1999 Apr 16;13(6):735-7
references.pmid: 10397574
references.citation: J Infect Dis. 2012 Jun;205 Suppl 3:S375-82
references.pmid: 22577211
references.citation: AIDS. 2012 Jan 28;26(3):303-14
references.pmid: 22089377
references.citation: Ann Intern Med. 1982 Jun;96(6 Pt 1):700-4
references.pmid: 6283974
references.citation: Clin Infect Dis. 2010 Oct 15;51(8):963-72
references.pmid: 20828304