title: Ag-silica composite nanotube with controlled wall structures for biomedical applications.
abstract: A range of Ag-silica composite nanotubes with tailored wall structures were successfully synthesized in situ by single-nozzle electrospinning. By increasing AgNO3 concentration, the wall structure of Ag-silica tubes changes from dense to porous, and eventually turns into a 'lace-like' structure. This is attributed to Ag ions doping into the SiOSi network of precursors, as illustrated in FTIR study. More importantly, Ag-silica composite nanotubes show robust antibacterial activity against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli microorganisms. Therefore, it is a breakthrough of the nanostructure biomaterial research for future medical applications that require strong antibacterial properties.
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: He
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.affiliation: College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Chang
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Xiwen
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. Electronic address: xiang.li@zju.edu.cn.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Weng
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Gaorong
authors.initials: G
authors.lastname: Han
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D020811:Biomedical Technology / Q000379:methods*; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D056951:Photoelectron Spectroscopy; D012822:Silicon Dioxide / Q000494:pharmacology*; D012834:Silver / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver; D012822:Silicon Dioxide
keywords: Ag-silica nanotube; Antibacterial; Controlled wall-structure; Electrospinning