title: Castration-resistant prostate cancer: a strategy to enhance response to androgen deprivation.
abstract: A new research study evaluated the mechanisms of prostate cancer (PCa) resistance to androgen deprivation therapy (ADT) and progression to castrate-resistant disease. Using a coclinical approach, the investigators were able to identify key genetic determinants of ADT resistance, gain insight into the molecular pathways that play a key role in this transition and propose a potential management strategy to overcome ADT resistance in select cancers. This represents a step forward towards personalized medicine guided by specific molecular markers of prostate cancer enabling more effective therapies targeted towards altered metabolic pathways.
authors.affiliation: Department of Urologic Surgery, The E. Wolfson Medical Center, Holon and Sackler school of Medicine, Tel Aviv University, Tel Aviv 53000, Israel.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Stanevsky
authors.forename: Alexander
authors.initials: A
authors.lastname: Tsivian
authors.forename: Matvey
authors.initials: M
authors.lastname: Tsivian
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use*; D000728:Androgens / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000628:therapy*; D035703:Therapies, Investigational
chemical_list: D000726:Androgen Antagonists; D000728:Androgens
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