title: Review: Glycation of human serum albumin.
abstract: Glycation involves the non-enzymatic addition of reducing sugars and/or their reactive degradation products to amine groups on proteins. This process is promoted by the presence of elevated blood glucose concentrations in diabetes and occurs with various proteins that include human serum albumin (HSA). This review examines work that has been conducted in the study and analysis of glycated HSA. The general structure and properties of HSA are discussed, along with the reactions that can lead to modification of this protein during glycation. The use of glycated HSA as a short-to-intermediate term marker for glycemic control in diabetes is examined, and approaches that have been utilized for measuring glycated HSA are summarized. Structural studies of glycated HSA are reviewed, as acquired for both in vivo and in vitro glycated HSA, along with data that have been obtained on the rate and thermodynamics of HSA glycation. In addition, this review considers various studies that have investigated the effects of glycation on the binding of HSA with drugs, fatty acids and other solutes and the potential clinical significance of these effects.
authors.affiliation: Chemistry Department, University of Nebraska, 704 Hamilton Hall, Lincoln, NE 68588-0304, USA.
authors.forename: Jeanethe
authors.initials: J
authors.lastname: Anguizola
authors.forename: Ryan
authors.initials: R
authors.lastname: Matsuda
authors.forename: Omar S
authors.initials: OS
authors.lastname: Barnaby
authors.forename: K S
authors.initials: KS
authors.lastname: Hoy
authors.forename: Chunling
authors.initials: C
authors.lastname: Wa
authors.forename: Erin
authors.initials: E
authors.lastname: DeBolt
authors.forename: Michelle
authors.initials: M
authors.lastname: Koke
authors.forename: David S
authors.initials: DS
authors.lastname: Hage
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000737:chemistry; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000201:enzymology* / Q000473:pathology; D005227:Fatty Acids / Q000097:blood / Q000737:chemistry; D005905:Glyburide / Q000097:blood / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000737:chemistry / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D007004:Hypoglycemic Agents / Q000097:blood / Q000737:chemistry; D007700:Kinetics; D008958:Models, Molecular; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism*; D013453:Sulfonylurea Compounds / Q000097:blood / Q000737:chemistry; D013816:Thermodynamics; D000093423:Glycated Serum Albumin
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D005227:Fatty Acids; D017127:Glycation End Products, Advanced; D007004:Hypoglycemic Agents; D012709:Serum Albumin; D013453:Sulfonylurea Compounds; D005905:Glyburide; D000093423:Glycated Serum Albumin
keywords: Diabetes; Drug–protein binding; Glycated albumin; Glycation; Human serum albumin; Protein modification
references.citation: Drug Saf. 2000 Apr;22(4):313-20
references.pmid: 10789825
references.citation: Ann Intern Med. 1994 Dec 15;121(12):912-8
references.pmid: 7978716
references.citation: Coll Relat Res. 1982 Jan;2(1):81-8
references.pmid: 7105648
references.citation: Clin Chim Acta. 2011 Aug 17;412(17-18):1606-15
references.pmid: 21601565
references.citation: Clin Chem. 1999 May;45(5):593-615
references.pmid: 10222345
references.citation: J Mol Biol. 2000 Nov 10;303(5):721-32
references.pmid: 11061971
references.citation: Clin J Am Soc Nephrol. 2011 Jul;6(7):1520-2
references.pmid: 21734081
references.citation: J Mass Spectrom. 2006 Sep;41(9):1179-85
references.pmid: 16924599
references.citation: Biochemistry. 1993 Jul 27;32(29):7574-80
references.pmid: 8338853
references.citation: Anal Bioanal Chem. 2011 Nov;401(9):2811-9
references.pmid: 21922305
references.citation: J Pharm Sci. 1982 Feb;71(2):235-8
references.pmid: 7062252
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 15;878(30):3193-7
references.pmid: 20974553
references.citation: Ann N Y Acad Sci. 2005 Jun;1043:260-6
references.pmid: 16037246
references.citation: Clin Chim Acta. 2002 Oct;324(1-2):61-71
references.pmid: 12204426
references.citation: Curr Alzheimer Res. 2004 Feb;1(1):39-46
references.pmid: 15975084
references.citation: J Biol Chem. 2005 Feb 18;280(7):5724-32
references.pmid: 15557329
references.citation: J Pharm Biomed Anal. 2011 Jan 25;54(2):426-32
references.pmid: 20880646
references.citation: J Biol Chem. 1999 Oct 8;274(41):29303-10
references.pmid: 10506189
references.citation: J Mass Spectrom. 2003 Feb;38(2):196-205
references.pmid: 12577286
references.citation: Acta Diabetol. 2011 Jun;48(2):167-72
references.pmid: 21153482
references.citation: Kidney Int. 2000 Nov;58(5):2228-34
references.pmid: 11044246
references.citation: J Mol Biol. 2001 Dec 14;314(5):955-60
references.pmid: 11743713
references.citation: Chirality. 2006 Sep;18(9):667-79
references.pmid: 16823814
references.citation: Arch Biochem Biophys. 1983 Mar;221(2):428-37
references.pmid: 6838198
references.citation: Biochimie. 2012 Sep;94(9):1960-7
references.pmid: 22627382
references.citation: J Biol Chem. 1979 Feb 10;254(3):595-7
references.pmid: 762083
references.citation: Diabetes Technol Ther. 1999 Spring;1(1):57-70
references.pmid: 11475306
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jun 1;878(19):1590-8
references.pmid: 20435530
references.citation: Drug Metab Pharmacokinet. 2005 Oct;20(5):309-23
references.pmid: 16272748
references.citation: Med Res Rev. 2003 May;23(3):275-301
references.pmid: 12647311
references.citation: Biochem J. 2003 Nov 1;375(Pt 3):581-92
references.pmid: 12885296
references.citation: J Biol Chem. 2003 Nov 21;278(47):46616-24
references.pmid: 12975371
references.citation: Protein Pept Lett. 2007;14(1):13-8
references.pmid: 17266645
references.citation: J Lipid Res. 1975 May;16(3):165-79
references.pmid: 236351
references.citation: Eur J Clin Chem Clin Biochem. 1992 Dec;30(12):851-9
references.pmid: 1489860
references.citation: Clin Chem. 2001 Feb;47(2):153-63
references.pmid: 11159762
references.citation: Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2218-22
references.pmid: 1549585
references.citation: Horm Metab Res. 1998 Sep;30(9):586-93
references.pmid: 9808329
references.citation: Biochem J. 1989 Aug 1;261(3):871-8
references.pmid: 2803249
references.citation: Diabetes Metab. 2012 Apr;38(2):171-8
references.pmid: 22349032
references.citation: Anal Chem. 2007 Aug 1;79(15):5991-9
references.pmid: 17571855
references.citation: Clin Chim Acta. 2012 Oct 9;413(19-20):1555-61
references.pmid: 22579765
references.citation: Acta Diabetol. 1997 Mar;34(1):49-54
references.pmid: 9134059
references.citation: Arch Biochem Biophys. 2012 Jun 1;522(1):17-25
references.pmid: 22516656
references.citation: J Biol Chem. 1983 May 25;258(10):6142-6
references.pmid: 6853480
references.citation: J Biol Chem. 1984 Mar 25;259(6):3812-7
references.pmid: 6706980
references.citation: Clin Chem. 2012 Dec;58(12):1615-7
references.pmid: 23115055
references.citation: J Biochem Biophys Methods. 1994 Mar;28(2):115-21
references.pmid: 8040561
references.citation: Anal Biochem. 2011 Mar 15;410(2):248-56
references.pmid: 21112314
references.citation: Ther Drug Monit. 1987 Dec;9(4):389-91
references.pmid: 3122377
references.citation: Pharm Res. 1988 May;5(5):261-5
references.pmid: 3149736
references.citation: J Pharm Biomed Anal. 2010 Nov 2;53(3):811-8
references.pmid: 20537832
references.citation: Diabetes Care. 1989 Jan;12(1):24-31
references.pmid: 2714164
references.citation: Clin Chim Acta. 2007 Oct;385(1-2):48-60
references.pmid: 17707360
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17958-63
references.pmid: 16330771
references.citation: J Chromatogr A. 2009 Apr 17;1216(16):3492-500
references.pmid: 18926542
references.citation: Biol Pharm Bull. 1993 Feb;16(2):195-8
references.pmid: 8364455
references.citation: Clin Biochem. 2007 Dec;40(18):1398-405
references.pmid: 17919531
references.citation: Mol Diagn Ther. 2010 Feb 1;14(1):49-51
references.pmid: 20121290
references.citation: Drug Metabol Drug Interact. 2008;23(1-2):125-50
references.pmid: 18533367
references.citation: Biochim Biophys Acta. 2003 Oct 13;1623(2-3):88-97
references.pmid: 14572906
references.citation: Am J Dis Child. 1976 Oct;130(10):1113-7
references.pmid: 973614
references.citation: Biopharm Drug Dispos. 1997 Dec;18(9):791-801
references.pmid: 9429743
references.citation: PLoS One. 2012;7(2):e32406
references.pmid: 22393405
references.citation: J Biol Chem. 1998 Sep 25;273(39):25272-8
references.pmid: 9737992
references.citation: Biochem Pharmacol. 1984 Oct 1;33(19):2967-71
references.pmid: 6487349
references.citation: J Immunol Methods. 1989 Sep 1;122(2):279-83
references.pmid: 2794522
references.citation: Eur J Heart Fail. 2007 Dec;9(12):1146-55
references.pmid: 18023248
references.citation: Methods Enzymol. 1984;106:88-98
references.pmid: 6436646
references.citation: Biomed Chromatogr. 1998 Jul-Aug;12(4):203-10
references.pmid: 9667024
references.citation: Anal Chem. 2013 May 7;85(9):4453-60
references.pmid: 23544441
references.citation: Anal Bioanal Chem. 2010 Jul;397(6):2349-56
references.pmid: 20496030
references.citation: J Clin Chem Clin Biochem. 1981 Feb;19(2):81-7
references.pmid: 6783732
references.citation: Anal Chem. 1998 Nov 1;70(21):4602-9
references.pmid: 9823719
references.citation: Biol Pharm Bull. 1994 Jan;17(1):16-21
references.pmid: 8148809
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15;878(28):2775-81
references.pmid: 20829128
references.citation: Clin Chem. 1984 Mar;30(3):446-9
references.pmid: 6697494
references.citation: J Am Soc Mass Spectrom. 2004 Apr;15(4):496-509
references.pmid: 15047055
references.citation: Mass Spectrom Rev. 2006 Sep-Oct;25(5):775-97
references.pmid: 16625652
references.citation: Mol Pharmacol. 1976 Nov;12(6):1052-61
references.pmid: 1004490
references.citation: Biochem Biophys Res Commun. 2001 Jun 1;284(1):83-9
references.pmid: 11374874
references.citation: Biochem J. 1999 Nov 15;344 Pt 1:109-16
references.pmid: 10548540
references.citation: J Chromatogr. 1992 Apr 24;597(1-2):271-5
references.pmid: 1517327
references.citation: J Chromatogr B Biomed Sci Appl. 1999 Mar 5;724(1):91-100
references.pmid: 10202961
references.citation: J Chromatogr. 1993 Aug 20;645(2):241-50
references.pmid: 8408417
references.citation: Clin Chim Acta. 2010 Aug 5;411(15-16):1102-10
references.pmid: 20394739
references.citation: Mol Pharmacol. 1975 Nov;11(6):824-32
references.pmid: 1207674
references.citation: J Protein Chem. 1995 Jul;14(5):359-72
references.pmid: 8590604
references.citation: J Pharm Biomed Anal. 2012 Oct;69:93-105
references.pmid: 22305083
references.citation: Eur J Clin Pharmacol. 1993;45(6):577-9
references.pmid: 8157046
references.citation: Anal Chem. 1994 Nov 1;66(21):3814-22
references.pmid: 7802261
references.citation: Clin Chim Acta. 2011 Jan 30;412(3-4):277-85
references.pmid: 21034726
references.citation: Ann N Y Acad Sci. 2008 Apr;1126:253-6
references.pmid: 18448825
references.citation: Biochem Pharmacol. 1992 Apr 15;43(8):1829-34
references.pmid: 1575775
references.citation: Ann N Y Acad Sci. 2005 Jun;1043:111-7
references.pmid: 16037229
references.citation: Neuro Endocrinol Lett. 2006 Feb-Apr;27(1-2):277-80
references.pmid: 16648799
references.citation: J Diabetes Sci Technol. 2008 Nov;2(6):1114-21
references.pmid: 19885300
references.citation: J Proteome Res. 2011 Jul 1;10(7):3076-88
references.pmid: 21612289
references.citation: Pharmacol Rep. 2005;57 Suppl:156-68
references.pmid: 16415497
references.citation: Mol Cell Proteomics. 2010 Mar;9(3):579-92
references.pmid: 19955080
references.citation: Anal Biochem. 2010 May 15;400(2):237-43
references.pmid: 20156417
references.citation: Clin Chim Acta. 1992 Nov 16;212(1-2):3-15
references.pmid: 1486680
references.citation: J Proteome Res. 2009 Feb;8(2):754-69
references.pmid: 19093874
references.citation: Clin Chem. 1998 Feb;44(2):256-63
references.pmid: 9474021
references.citation: Diabetologia. 2001 Feb;44(2):129-46
references.pmid: 11270668
references.citation: Clin Chem. 1987 Dec;33(12):2153-63
references.pmid: 3319287
references.citation: Proteomics. 2010 Jan;10(1):48-58
references.pmid: 19899078
references.citation: Arch Biochem Biophys. 2005 Dec 15;444(2):92-9
references.pmid: 16309624
references.citation: Recent Prog Horm Res. 2001;56:1-21
references.pmid: 11237208
references.citation: Clin Chem. 1994 Sep;40(9):1766-73
references.pmid: 8070089
references.citation: J Proteome Res. 2008 May;7(5):2025-32
references.pmid: 18396901
references.citation: Vet Clin Pathol. 2006 Sep;35(3):307-10
references.pmid: 16967414
references.citation: Biochem J. 2002 May 15;364(Pt 1):15-24
references.pmid: 11988071
references.citation: Clin Chem. 1994 Oct;40(10):1950-5
references.pmid: 7923778
references.citation: Eur Heart J. 2004 Feb;25(4):342-8
references.pmid: 14984924
references.citation: Prog Clin Biol Res. 1989;304:69-84
references.pmid: 2780681
references.citation: J Chromatogr. 1992 Jun 10;577(2):305-15
references.pmid: 1400761
references.citation: J Biol Chem. 1986 Oct 15;261(29):13542-5
references.pmid: 3759977
references.citation: Clin Chim Acta. 2007 Jul;382(1-2):59-64
references.pmid: 17482589
references.citation: Anal Bioanal Chem. 2013 Jul;405(17):5833-41
references.pmid: 23657448
references.citation: Clin Pharmacol Ther. 1984 Nov;36(5):691-5
references.pmid: 6488690
references.citation: J Chromatogr A. 2012 Nov 23;1265:114-22
references.pmid: 23092871
references.citation: J Mass Spectrom. 2005 Jul;40(7):969-72
references.pmid: 15768376
references.citation: Nat Struct Biol. 1998 Sep;5(9):827-35
references.pmid: 9731778
references.citation: Nature. 1992 Jul 16;358(6383):209-15
references.pmid: 1630489
references.citation: J Sep Sci. 2009 Apr;32(8):1145-55
references.pmid: 19296478
references.citation: Clin Chem. 2005 Oct;51(10):1991-2
references.pmid: 16299899
references.citation: Biochem J. 2002 May 15;364(Pt 1):1-14
references.pmid: 11988070
references.citation: J Biol Chem. 2005 Jun 17;280(24):22582-9
references.pmid: 15837789