title: Regulatory T cells as a therapeutic tool to induce solid-organ transplant tolerance: current clinical experiences.
abstract: Long-term tolerance is potentially an ideal in organ transplant. Achieving this leads us to eliminate immunosuppressive therapies and their associated side effects. Although most succession in this field belongs to mixed chimerism methods of tolerance induction, regulatory T cells and (T-reg)-based methods also have been demonstrated to prevent organ rejection and lead to transplant tolerance through different mechanisms. In contrast to chimeric protocols (which require bone marrow transplant), T-reg-mediated protocols do not aggressively manipulate blood and the immune system. Most treatment has been done for graft-versus-host disease after hematopoietic stem cell transplant. This review describes different types and mechanisms of action and clinical strategies using T-regs to induce transplant tolerance.
authors.affiliation: Department of Nephrology and Urology Research Center, Bagiyatallah University of Medical Sciences, Bagiyatallah Hospital, Tehran, I.R. Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Nikoueinejad
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Sharif
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Amirzargar
authors.forename: Abbas
authors.initials: A
authors.lastname: Mirshafiey
authors.forename: Behzad
authors.initials: B
authors.lastname: Einollahi
mesh_terms: D019264:Adoptive Transfer; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016377:Organ Transplantation / Q000009:adverse effects*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology / Q000637:transplantation*; D013997:Time Factors; D023001:Transplantation Tolerance; D016896:Treatment Outcome
chemical_list: D007155:Immunologic Factors; D007166:Immunosuppressive Agents