title: Assessment of the left atrial volume index and plasma NT-proANP level in patients with acute ST-elevation myocardial infarction.
abstract: OBJECTIVE
  Acute ST-elevation myocardial infarction is associated with ventricular dysfunction due to ischemia-induced progressive myocardial damage. The decrease in ventricular compliance causes left atrial dilatation and stretching of the atrial myocardium, which are the main stimuli for the secretion of atrial natriuretic peptide. The aim of this study was to evaluate left atrial dimensions and atrial natriuretic peptide levels in patients early after their first acute ST-elevation myocardial infarction and assess the probable interaction between coronary lesions and these measurements.
  
  
  METHODS
  A total of 110 patients with acute myocardial infarction and 50 controls were studied. Plasma atrial natriuretic peptide was measured at admission. Left ventricular function, diameter, and volume index were evaluated using transthoracic echocardiography. Gensini and vessel scores of the patients who underwent coronary angiography were calculated.
  
  
  RESULTS
  Plasma atrial natriuretic peptide in the patients with myocardial infarction was increased compared with that in controls (3.90±3.75 vs. 1.35±0.72 nmol/L, p<0.001). Although the left atrial diameter was comparable in patients and controls, the left atrial volume index was increased in patients with acute myocardial infarction (26.5±7.1 vs. 21.3±4.9 mL/m2, p<0.01). Multivariate regression analysis showed a strong independent correlation between the left atrial volume index and the plasma atrial natriuretic peptide level (β=0.23, p=0.03).
  
  
  CONCLUSIONS
  The left atrial volume index and plasma atrial natriuretic peptide level were correlated in patients with acute myocardial infarction.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bezmialem Foundation University, Istanbul, Turkey. ahmetbacaxiz@yandex.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bacaksiz
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Vatankulu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kayrak
authors.forename: Hasan Huseyin
authors.initials: HH
authors.lastname: Telli
authors.forename: Selim S
authors.initials: SS
authors.lastname: Ayhan
authors.forename: Osman
authors.initials: O
authors.lastname: Sonmez
authors.forename: Ayse
authors.initials: A
authors.lastname: Alp
authors.forename: Sadik
authors.initials: S
authors.lastname: Buyukbas
mesh_terms: D000368:Aged; D016279:Atrial Function, Left / Q000502:physiology*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D017023:Coronary Angiography; D004452:Echocardiography; D005260:Female; D006325:Heart Atria / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology*; D011446:Prospective Studies; D013318:Stroke Volume / Q000502:physiology*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D009320:Atrial Natriuretic Factor
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