title: Oxidative stress and immunological alteration in women with preeclampsia.
abstract: OBJECTIVE
  To determine plasma concentrations of malondialdehyde (MDA) and of inflammatory markers in women with preeclampsia.
  
  
  METHODS
  A case-control study was conducted on 50 preeclamptic and 50 healthy pregnant women. The concentrations of MDA were determined by the method of thiobarbituric acid reactive substances. Markers of inflammation were determined by the multiplex method.
  
  
  RESULTS
  The concentrations of MDA did not differ between groups (p > 0.05) and the preeclampsia group had significantly higher IL-6, IL-10, TNF-α and IL-6/IL-10 ratio, compared to those with normal pregnancy.
  
  
  CONCLUSIONS
  The MDA is a nonspecific marker for oxidative stress in preeclampsia, and the gestantes with preeclampsia have immune dysfunction.
authors.affiliation: Nutrition Department, Federal University of Piauí, Teresina, Brazil.
authors.forename: Danilla Michelle Costa e
authors.initials: DM
authors.lastname: Silva
authors.forename: Dilina do Nascimento
authors.initials: Ddo N
authors.lastname: Marreiro
authors.forename: José Machado
authors.initials: JM
authors.lastname: Moita Neto
authors.forename: José Araújo
authors.initials: JA
authors.lastname: Brito
authors.forename: Eunice Alves da Silva
authors.initials: EA
authors.lastname: Neta
authors.forename: Juliana Paz
authors.initials: JP
authors.lastname: Matias
authors.forename: Fabiane Araújo
authors.initials: FA
authors.lastname: Sampaio
authors.forename: Nadir do Nascimento
authors.initials: Ndo N
authors.lastname: Nogueira
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D008315:Malondialdehyde