title: Aluminium and breast cancer: Sources of exposure, tissue measurements and mechanisms of toxicological actions on breast biology.
abstract: This review examines recent evidence linking exposure to aluminium with the aetiology of breast cancer. The human population is exposed to aluminium throughout daily life including through diet, application of antiperspirants, use of antacids and vaccination. Aluminium has now been measured in a range of human breast structures at higher levels than in blood serum and experimental evidence suggests that the tissue concentrations measured have the potential to adversely influence breast epithelial cells including generation of genomic instability, induction of anchorage-independent proliferation and interference in oestrogen action. The presence of aluminium in the human breast may also alter the breast microenvironment causing disruption to iron metabolism, oxidative damage to cellular components, inflammatory responses and alterations to the motility of cells. The main research need is now to investigate whether the concentrations of aluminium measured in the human breast can lead in vivo to any of the effects observed in cells in vitro and this would be aided by the identification of biomarkers specific for aluminium action.
authors.affiliation: School of Biological Sciences, University of Reading, Reading RG6 6UB, UK. Electronic address: p.d.darbre@reading.ac.uk.
authors.forename: Philippa D
authors.initials: PD
authors.lastname: Darbre
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Mannello
authors.forename: Christopher
authors.initials: C
authors.lastname: Exley
mesh_terms: D000535:Aluminum / Q000009:adverse effects* / Q000378:metabolism; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D042822:Genomic Instability / Q000187:drug effects*; D006801:Humans; D012307:Risk Factors; D059016:Tumor Microenvironment / Q000187:drug effects / Q000235:genetics
chemical_list: D000535:Aluminum
keywords: Aluminium; Antiperspirant; Breast cancer; Breast cyst fluid; Nipple aspirate fluid