title: Role of TSH on Urinary Calcium Excretion In Post Menopausal Women of South Indian Population.
abstract: BACKGROUND
  Unforeseen aberrations in the hormonal status during the early postmenopausal period are responsible for several complications including osteoporosis. Thyroid Stimulating Hormone (TSH) receptors are isolated from various tissues including the bone. A low serum TSH level is known to stimulate osteoclastic activity in bone and accelerate bone resorption. Urinary calcium/creatinine (UCa/Cr) excretion ratio could be an indirect and an early indicator of loss of Bone Mineral Density (BMD). With this background, this study was planned to explore the association of serum TSH levels with the UCa/Cr excretion ratio.
  
  
  METHODS
  Forty eight women in the postmenopausal age group, with their menopausal age not more than seven years of duration were included in this study. Based on their TSH values, these subjects were divided into two groups A (TSH<0.5 mIU/L) and B (TSH>0.5mIU/L). Urinary calcium, UCa/Cr excretion ratio, serum phosphorous, calcium and calcium phosphorous multiplication products were estimated and compared between the two groups.
  
  
  RESULTS
  Twenty two (46%) women were biochemically asymptomatic hyperthyroid cases and Twenty six (54%) were euthyroid. This study documents high UCa/Cr in Group A compared to that of Group B (p<0.05). We also observed significant negative correlation of TSH with UCa/Cr excretion ratio (p=0.041, r = -0.43).
  
  
  CONCLUSIONS
  Low serum TSH levels were associated with increased UCa/Cr excretion ratio in postmenopausal women of South Indian population.
authors.affiliation: Assistant Professor, Department of Biochemistry.
authors.forename: Niranjan
authors.initials: N
authors.lastname: G
authors.forename: Amrutha
authors.initials: A
authors.lastname: P V
authors.forename: Srinivasan
authors.initials: S
authors.lastname: A R
authors.forename: Ramesh
authors.initials: R
authors.lastname: R
authors.forename: Sathishbabu
authors.initials: S
authors.lastname: M
authors.forename: Sathiya
authors.initials: S
authors.lastname: R
keywords: Post Menopausal Women; Thyroid Stimulating Hormone; Urinary Calcium/creatinine ratio; Urinary calcium
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