title: Role of COMT in ADHD: a systematic meta-analysis.
abstract: Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable childhood-onset psychiatric disorder with significant genetic contribution. Considerable evidence has implicated involvement of dopaminergic system and the prefrontal cortex (PFC) in the pathomechanism of ADHD. The catechol-O-methyltransferase (COMT) gene is of particular interest for ADHD as its crucial role in the degradation of dopamine in the PFC. We summarized the reported findings investigating associations between COMT gene and ADHD and performed a meta-analysis of previous studies to assess the overall magnitude and significance of the association.
authors.affiliation: Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Sun
authors.forename: Fangfen
authors.initials: F
authors.lastname: Yuan
authors.forename: Xuemei
authors.initials: X
authors.lastname: Shen
authors.forename: Guanglian
authors.initials: G
authors.lastname: Xiong
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
mesh_terms: D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000201:enzymology* / Q000235:genetics*; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000502:physiology*; D004298:Dopamine / Q000009:adverse effects / Q000378:metabolism; D059647:Gene-Environment Interaction; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017397:Prefrontal Cortex / Q000201:enzymology / Q000473:pathology
chemical_list: C588010:COMT protein, human; D002394:Catechol O-Methyltransferase; D004298:Dopamine
references.citation: Psychiatr Genet. 2000 Sep;10(3):117-24
references.pmid: 11204347
references.citation: J Psychosom Res. 2002 Aug;53(2):647-54
references.pmid: 12169339
references.citation: J Clin Psychiatry. 2010 Jul;71(7):e17
references.pmid: 20667287
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1392-8
references.pmid: 18988193
references.citation: Biol Psychiatry. 2005 Jun 1;57(11):1313-23
references.pmid: 15950004
references.citation: Eur J Neurosci. 2002 Jan;15(2):246-56
references.pmid: 11849292
references.citation: Proc Natl Acad Sci U S A. 2003 May 13;100(10):6186-91
references.pmid: 12716966
references.citation: J Neural Transm Suppl. 1995;45:35-45
references.pmid: 8748607
references.citation: Am J Med Genet. 1999 Dec 15;88(6):628-33
references.pmid: 10581481
references.citation: Am J Hum Genet. 2003 Jul;73(1):152-61
references.pmid: 12802784
references.citation: J Comput Aided Mol Des. 1998 May;12(3):301-7
references.pmid: 9749372
references.citation: Pharmacol Rev. 1999 Dec;51(4):593-628
references.pmid: 10581325
references.citation: Brain Res. 1980 Aug 4;194(2):556-60
references.pmid: 7388632
references.citation: Nucleic Acids Res. 2012 Jan;40(Database issue):D1003-9
references.pmid: 22080511
references.citation: Arch Gen Psychiatry. 1992 Sep;49(9):728-38
references.pmid: 1514878
references.citation: J Biol Chem. 2011 Oct 7;286(40):34752-60
references.pmid: 21846718
references.citation: PLoS One. 2012;7(2):e28839
references.pmid: 22363396
references.citation: Biol Psychiatry. 2001 Feb 15;49(4):333-9
references.pmid: 11239904
references.citation: J Atten Disord. 2014 Apr;18(3):202-11
references.pmid: 22451510
references.citation: Cereb Cortex. 2007 May;17(5):1206-12
references.pmid: 16835293
references.citation: Neuroendocrinology. 1980 Sep;31(3):222-7
references.pmid: 6774278
references.citation: Aust N Z J Psychiatry. 2007 Jan;41(1):10-6
references.pmid: 17464676
references.citation: Mol Psychiatry. 1996 May;1(2):121-4
references.pmid: 9118321
references.citation: Prog Brain Res. 1990;85:325-35; discussion 335-6
references.pmid: 2094903
references.citation: J Biol Chem. 1998 Dec 4;273(49):32776-86
references.pmid: 9830022
references.citation: Biol Psychiatry. 2011 Aug 1;70(3):216-21
references.pmid: 21550019
references.citation: Arch Gen Psychiatry. 1973 Jun;28(6):888-91
references.pmid: 4707995
references.citation: Science. 2006 Dec 22;314(5807):1930-3
references.pmid: 17185601
references.citation: Lancet. 1999 Dec 18-25;354(9196):2132-3
references.pmid: 10609822
references.citation: Genomics. 1992 Apr;12(4):822-5
references.pmid: 1572656
references.citation: Child Adolesc Psychiatr Clin N Am. 2001 Apr;10(2):299-316, viii-ix
references.pmid: 11351800
references.citation: J Neural Transm Gen Sect. 1995;101(1-3):83-94
references.pmid: 8695059
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2003 Apr 1;118B(1):103-9
references.pmid: 12627475
references.citation: Int J Neuropsychopharmacol. 2007 Jun;10(3):301-8
references.pmid: 16734939
references.citation: Am J Psychiatry. 2007 Jun;164(6):942-8
references.pmid: 17541055
references.citation: Am J Hum Genet. 1995 Apr;56(4):993-8
references.pmid: 7717410
references.citation: Biol Psychiatry. 2005 Jun 1;57(11):1215-20
references.pmid: 15949990
references.citation: Nat Neurosci. 2005 May;8(5):594-6
references.pmid: 15821730
references.citation: J Neurochem. 2010 Sep;114(6):1745-55
references.pmid: 20626558
references.citation: Science. 1999 Jan 15;283(5400):397-401
references.pmid: 9888856
references.citation: Neuroreport. 1998 May 11;9(7):1305-8
references.pmid: 9631418
references.citation: Neuroscience. 2008 Sep 9;155(4):1021-9
references.pmid: 18674597
references.citation: Eur J Neurosci. 1999 Oct;11(10):3499-511
references.pmid: 10564358
references.citation: Biol Psychiatry. 2005 Jun 1;57(11):1442-51
references.pmid: 15950019
references.citation: NeuroRx. 2006 Jan;3(1):97-105
references.pmid: 16490416
references.citation: Biol Psychiatry. 2006 Sep 15;60(6):578-84
references.pmid: 16730334
references.citation: Nat Rev Neurosci. 2006 Jun;7(6):477-84
references.pmid: 16688123
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1345-54
references.pmid: 18821565
references.citation: Biol Psychiatry. 2005 Jun 1;57(11):1336-46
references.pmid: 15950006
references.citation: Gene. 1990 Sep 14;93(2):241-7
references.pmid: 2227437
references.citation: J Am Acad Child Adolesc Psychiatry. 2000 Nov;39(11):1432-7
references.pmid: 11068899
references.citation: Neurosci Biobehav Rev. 2000 Jan;24(1):133-6
references.pmid: 10654669
references.citation: Neuropsychopharmacology. 2004 Nov;29(11):1943-61
references.pmid: 15305167
references.citation: DNA Cell Biol. 1993 Apr;12(3):253-63
references.pmid: 8466648
references.citation: Pharmacol Rev. 1975 Jun;27(2):135-206
references.pmid: 1103160
references.citation: Eur J Biochem. 1997 Jan 15;243(1-2):452-9
references.pmid: 9030772
references.citation: J Consult Clin Psychol. 2004 Oct;72(5):757-66
references.pmid: 15482034
references.citation: J Neural Transm. 1976;38(3-4):271-6
references.pmid: 956813
references.citation: DNA Cell Biol. 1991 Apr;10(3):181-9
references.pmid: 1707278
references.citation: Nat Struct Biol. 2001 Mar;8(3):271-9
references.pmid: 11224575
references.citation: Neurosci Biobehav Rev. 2004 Nov;28(7):771-84
references.pmid: 15555683
references.citation: Trends Cogn Sci. 1998 Nov 1;2(11):436-47
references.pmid: 21227275
references.citation: Thromb Haemost. 1978 Feb 28;39(1):238-9
references.pmid: 580500
references.citation: Pharmacogenetics. 1996 Jun;6(3):243-50
references.pmid: 8807664
references.citation: Am J Med Genet. 2000 Oct 9;96(5):599-603
references.pmid: 11054766
references.citation: Biochim Biophys Acta. 1995 Aug 16;1251(1):1-10
references.pmid: 7647086
references.citation: Nature. 1996 Feb 15;379(6566):606-12
references.pmid: 8628395
references.citation: J Neural Transm (Vienna). 2010 Feb;117(2):259-67
references.pmid: 19946713
references.citation: Clin Exp Pharmacol Physiol. 2001 Apr;28(4):285-9
references.pmid: 11251641
references.citation: Biol Psychiatry. 2005 Jun 1;57(11):1367-73
references.pmid: 15950009
references.citation: Int J Biochem. 1983;15(5):733-8
references.pmid: 6862087
references.citation: Proteins. 1991;11(3):233-6
references.pmid: 1749777
references.citation: J Neural Transm. 1976;38(3-4):277-301
references.pmid: 956814
references.citation: Can J Psychiatry. 1996 Aug;41(6):350-60
references.pmid: 8862854
references.citation: Basic Clin Pharmacol Toxicol. 2012 Apr;110(4):307-13
references.pmid: 21851556
references.citation: Hum Genet. 2009 Jul;126(1):51-90
references.pmid: 19506906
references.citation: Brain Res. 2002 May 17;936(1-2):58-67
references.pmid: 11988230
references.citation: J Child Psychol Psychiatry. 1975 Jul;16(3):261-4
references.pmid: 1171894
references.citation: Biol Psychiatry. 2006 Jul 15;60(2):141-51
references.pmid: 16476412
references.citation: Eur J Biochem. 1994 Aug 1;223(3):1049-59
references.pmid: 8055944
references.citation: Neurosci Lett. 2000 May 12;285(2):107-10
references.pmid: 10793238
references.citation: Am J Med Genet. 1997 Jul 25;74(4):439-42
references.pmid: 9259381
references.citation: Biol Psychiatry. 1998 Nov 15;44(10):951-8
references.pmid: 9821559
references.citation: J Abnorm Psychol. 1995 May;104(2):334-345
references.pmid: 7790635
references.citation: Mol Pharmacol. 1998 Aug;54(2):342-52
references.pmid: 9687576
references.citation: Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4572-5
references.pmid: 9114031
references.citation: J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):858-68
references.pmid: 8083143
references.citation: Biol Psychiatry. 2007 Oct 15;62(8):847-55
references.pmid: 17544382
references.citation: Mol Neurobiol. 2012 Jun;45(3):605-20
references.pmid: 22610946
references.citation: Biol Psychiatry. 1999 May 1;45(9):1178-89
references.pmid: 10331110
references.citation: Ann N Y Acad Sci. 2001 Jun;931:50-83
references.pmid: 11462757
references.citation: Neuroscience. 2003;116(1):127-37
references.pmid: 12535946
references.citation: Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9991-6
references.pmid: 9707588
references.citation: Lancet. 1998 Feb 7;351(9100):429-33
references.pmid: 9482319
references.citation: Biochemistry. 1982 Apr 13;21(8):1740-2
references.pmid: 7082642
references.citation: Eur Child Adolesc Psychiatry. 2006 Mar;15(2):118-25
references.pmid: 16523253
references.citation: Neuroreport. 1998 Aug 24;9(12):2861-4
references.pmid: 9760135
references.citation: Behav Brain Res. 2012 Mar 17;228(2):351-8
references.pmid: 22192380
references.citation: J Neurochem. 1994 Sep;63(3):972-9
references.pmid: 7914228
references.citation: Clin Ther. 2009 Oct;31(10):2258-71
references.pmid: 19922897
references.citation: Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6917-22
references.pmid: 11381111
references.citation: Am J Hum Genet. 1997 Sep;61(3):620-9
references.pmid: 9326327
references.citation: J Neurochem. 1991 Jun;56(6):1940-8
references.pmid: 1709201
references.citation: Int J Dev Neurosci. 1995 Dec;13(8):825-34
references.pmid: 8770656
references.citation: Biochemistry. 1995 Apr 4;34(13):4202-10
references.pmid: 7703232
references.citation: Rev Physiol Biochem Pharmacol. 1992;120:1-29
references.pmid: 1519017
references.citation: J Neurochem. 1993 Oct;61(4):1369-75
references.pmid: 8104232
references.citation: Biol Psychiatry. 2000 Jul 1;48(1):9-20
references.pmid: 10913503
references.citation: J Biol Chem. 1980 Oct 10;255(19):9124-7
references.pmid: 6997310
references.citation: J Neurosci. 2001 Jan 1;21(1):35-44
references.pmid: 11150317
references.citation: J Neurosci. 2008 Aug 27;28(35):8709-23
references.pmid: 18753372
references.citation: Nat Genet. 2008 Jul;40(7):827-34
references.pmid: 18583979
references.citation: J Neural Transm (Vienna). 2008 Nov;115(11):1573-85
references.pmid: 18839057
references.citation: Biol Psychiatry. 1994 Mar 15;35(6):398-402
references.pmid: 8018786
references.citation: Brain Res. 1999 Oct 2;843(1-2):136-44
references.pmid: 10528120
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2003 Nov 15;123B(1):64-9
references.pmid: 14582147
references.citation: Eur Child Adolesc Psychiatry. 2004 Aug;13(4):243-8
references.pmid: 15365895
references.citation: Biol Psychiatry. 1998 Mar 15;43(6):425-31
references.pmid: 9532347
references.citation: J Neurochem. 1993 Aug;61(2):637-47
references.pmid: 8336146
references.citation: Neurosci Biobehav Rev. 2011 Aug;35(8):1665-86
references.pmid: 21527290
references.citation: Pharmacol Toxicol. 2003 Jun;92(6):272-8
references.pmid: 12787259
references.citation: Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1416-20
references.pmid: 1847521
references.citation: Biol Psychiatry. 1999 Aug 15;46(4):557-67
references.pmid: 10459407
references.citation: Am J Hum Genet. 1977 Mar;29(2):125-35
references.pmid: 848488
references.citation: Mol Psychiatry. 1998 Jul;3(4):342-5
references.pmid: 9702744
references.citation: J Neurosci. 1998 Apr 1;18(7):2697-708
references.pmid: 9502827
references.citation: Mol Psychiatry. 2007 Jun;12(6):556-61
references.pmid: 17264842
references.citation: Pharmacogenetics. 1997 Oct;7(5):349-53
references.pmid: 9352569
references.citation: Am J Hum Genet. 2002 Dec;71(6):1296-302
references.pmid: 12402217
references.citation: Nature. 1994 Mar 24;368(6469):354-8
references.pmid: 8127373
references.citation: Mol Pharmacol. 2002 Oct;62(4):795-805
references.pmid: 12237326