title: Polypyrrole hollow microspheres as echogenic photothermal agent for ultrasound imaging guided tumor ablation.
abstract: Ultrasound (US) imaging provides a valuable opportunity to administer photothermal therapy (PTT) of cancer with real-time guidance to ensure proper targeting, but only a few theranostic agents were developed by physically grafting near infrared (NIR)-absorbing inorganic nanomaterials to ready-made ultrasound contrast agents (UCAs) for US imaging guided PTT. In this paper, NIR absorbing hollow microspheres were generated from polypyrrole merely using a facile one-step microemulsion method. It was found that the obtained polypyrrole hollow microspheres (PPyHMs) can act as an efficient theranostic agent not only to enhance US imaging greatly, but also exhibit excellent photohyperthermic effects. The contrast consistently sustained the echo signals for no less than 5 min and the NIR laser light ablated the tumor completely within two weeks in the presence of PPyHMs. More importantly, no use of additional NIR absorber substantially minimizes an onetime dose of the theranostic agent.
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Zhengbao
authors.initials: Z
authors.lastname: Zha
authors.forename: Jinrui
authors.initials: J
authors.lastname: Wang
authors.forename: Enze
authors.initials: E
authors.lastname: Qu
authors.forename: Shuhai
authors.initials: S
authors.lastname: Zhang
authors.forename: Yushen
authors.initials: Y
authors.lastname: Jin
authors.forename: Shumin
authors.initials: S
authors.lastname: Wang
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media; D006801:Humans; D008863:Microspheres; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D010789:Phototherapy / Q000379:methods*; D011108:Polymers / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use*; D011817:Rabbits; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D003287:Contrast Media; D017319:Photosensitizing Agents; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole
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