title: Delayed Liver Function Impairment Secondary to Interferon β-1a Use in Multiple Sclerosis.
abstract: Interferon β-1a is a widely used immunomodulation treatment for multiple sclerosis. Liver function impairment is a common side effect and usually develops in the first 6 months after interferon use. Here, we describe 2 multiple sclerosis patients who developed delayed liver function impairment 5 years after receiving interferon β-1a treatment. Their liver function recovered after discontinuing interferon use, and further detailed hepatological evaluations excluded other etiologies of liver function impairment. Our case reports illustrate that liver function impairment induced by interferon β-1a can be delayed for 5 years after starting treatment and, probably, this is an idiosyncratic reaction. Regular liver function monitoring in multiple sclerosis patients who receive interferon β is necessary even after the first 6 months of treatment, especially in those patients with concomitant use of other liver-toxic medications.
authors.affiliation: Department of Neurology, Chang-Gung University, Taipei, Taiwan, ROC ; College of Medicine, Chang-Gung University, Taipei, Taiwan, ROC.
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Liao
authors.forename: Su-Chen
authors.initials: SC
authors.lastname: Yen
authors.forename: Lin
authors.initials: L
authors.lastname: Chun-Yen
authors.forename: Lyu
authors.initials: L
authors.lastname: Rong-Kuo
keywords: Azathioprine; Hepatitis; Interferon β; Liver function impairment; Multiple sclerosis
references.citation: Mult Scler. 2009 Aug;15(8):965-76
references.pmid: 19465443
references.citation: Drug Saf. 2003;26(11):815-27
references.pmid: 12908850
references.citation: J Clin Epidemiol. 1993 Nov;46(11):1323-30
references.pmid: 8229110
references.citation: Mult Scler. 2005 Apr;11(2):169-74
references.pmid: 15794390
references.citation: Ann Hepatol. 2006 Jan-Mar;5(1):56-9
references.pmid: 16531969
references.citation: Ann Neurol. 2011 Feb;69(2):292-302
references.pmid: 21387374
references.citation: Eur Neurol. 2004;51(1):15-20
references.pmid: 14631124
references.citation: J Neurol Neurosurg Psychiatry. 2004 May;75(5):706-10
references.pmid: 15090564
references.citation: Neurology. 2006 Oct 10;67(7):1291-3
references.pmid: 17030771
references.citation: Neurology. 2006 May 23;66(10):1485-9
references.pmid: 16717206
references.citation: J Neurol. 2005 Jul;252(7):855-6
references.pmid: 15742101
references.citation: Lancet. 1998 Nov 7;352(9139):1498-504
references.pmid: 9820297
references.citation: Mult Scler. 2011 Mar;17(3):361-7
references.pmid: 21148660
references.citation: Neurology. 2001 Jun 26;56(12):1628-36
references.pmid: 11425926