title: In vivo whole animal fluorescence imaging of a microparticle-based oral vaccine containing (CuInSe(x)S(2-x))/ZnS core/shell quantum dots.
abstract: Zinc sulfide-coated copper indium sulfur selenide (CuInSexS2-x/ZnS core/shell) nanocrystals were synthesized with size-tunable red to near-infrared (NIR) fluorescence with high quantum yield (40%) in water. These nanocrystals were tested as an imaging agent to track a microparticle-based oral vaccine administered to mice. Poly(lactic-co-glycolic acid) (PLGA) microparticle-encapsulated CuInSexSe2-x/ZnS quantum dots were orally administered to mice and were found to provide a distinct visible fluorescent marker in the gastrointestinal tract of living mice.
authors.affiliation: Department of Chemical Engineering, Texas Materials Institute, and Center for Nano- and Molecular Science and Technology, The University of Texas at Austin , Austin, Texas 78712, United States.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Panthani
authors.forename: Tarik A
authors.initials: TA
authors.lastname: Khan
authors.forename: Dariya K
authors.initials: DK
authors.lastname: Reid
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Hellebusch
authors.forename: Michael R
authors.initials: MR
authors.lastname: Rasch
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Maynard
authors.forename: Brian A
authors.initials: BA
authors.lastname: Korgel
mesh_terms: D000818:Animals; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging*; D007204:Indium / Q000737:chemistry; D019344:Lactic Acid / Q000008:administration & dosage / Q000737:chemistry; D051379:Mice; D061848:Optical Imaging; D011100:Polyglycolic Acid / Q000008:administration & dosage / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D045663:Quantum Dots / Q000737:chemistry*; D011859:Radiography; D018036:Selenium Compounds / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry; D014867:Water / Q000737:chemistry; D051598:Whole Body Imaging; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D018036:Selenium Compounds; D013440:Sulfides; D017967:Zinc Compounds; D007204:Indium; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C044696:zinc selenide
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