title: Breast Cancer during Pregnancy: An Interdisciplinary Approach in Our Institution.
abstract: BACKGROUND
  Breast cancer is the most common cancer diagnosed during pregnancy.
  
  
  METHODS
  We report on a case of a 26-year-old woman who was diagnosed with right-sided breast cancer in her 15th week of gestation. We discussed possible treatment scenarios and the patient opted for neoadjuvant therapy with taxanes and anthracyclines during pregnancy, followed by delivery and then followed by surgery, antibody therapy, and radiotherapy. The patient received neoadjuvant chemotherapy with paclitaxel 80 mg/m(2) weekly for 12 cycles, followed by 4 cycles of epirubicin and cyclophosphamide (90/600 mg/m(2)) every 3 weeks. Complete clinical response was seen after preoperative chemotherapy. After delivery of a healthy child at 40 weeks of gestation, she received breast-conserving surgery and axillary dissection. Anti-HER2 antibody treatment with trastuzumab was started concomitantly with adjuvant radiotherapy. Endocrine treatment with a gonadotropin-releasing hormone (GnRH) analog and tamoxifen for 5 years was planned to be started after radiotherapy.
  
  
  CONCLUSIONS
  Treatment of breast cancer during pregnancy requires an interdisciplinary approach and careful consideration of the patient's stage of disease, the gestational age, and the preferences of the patient and her family.
authors.affiliation: Department of Gynecology and Obstetrics, Helios Hospital Berlin-Buch, Germany.
authors.forename: Cristina
authors.initials: C
authors.lastname: Pirvulescu
authors.forename: Christine
authors.initials: C
authors.lastname: Mau
authors.forename: Holger
authors.initials: H
authors.lastname: Schultz
authors.forename: Antje
authors.initials: A
authors.lastname: Sperfeld
authors.forename: Annette
authors.initials: A
authors.lastname: Isbruch
authors.forename: Heike
authors.initials: H
authors.lastname: Renner-Lützkendorf
authors.forename: Sybille
authors.initials: S
authors.lastname: Loibl
authors.forename: Ulrike
authors.initials: U
authors.lastname: Freitag
authors.forename: Gabriele
authors.initials: G
authors.lastname: Klühs
authors.forename: Barbara
authors.initials: B
authors.lastname: Fleige
authors.forename: Michael
authors.initials: M
authors.lastname: Untch
keywords: Interdisciplinary care; Neoadjuvant chemotherapy; Outcome of pregnancy; Pregnancy-associated breast cancer
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