title: Effect of implantation of biodegradable magnesium alloy on BMP-2 expression in bone of ovariectomized osteoporosis rats.
abstract: The study was focused on the implantation of a biodegradable AZ31 magnesium alloy into the femoral periosteal of the osteoporosis modeled rats. The experimental results showed that after 4weeks implantation of AZ31 alloy in the osteoporosis modeled rats, the expression of BMP-2 in bone tissues of the rats was much enhanced, even higher than the control group, which should promote the bone formation and be beneficial for reducing the harmful effect of osteoporosis. Results of HE stains showed that the implantation of AZ31 alloy did not have obvious pathological changes on both the liver and kidney of the animal.
authors.affiliation: Liaoning Medical University, 40 Songpo Road, Jinzhou, 121000, China. 373073766@qq.com
authors.forename: Yue
authors.initials: Y
authors.lastname: Guo
authors.forename: Ling
authors.initials: L
authors.lastname: Ren
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Yajiang
authors.initials: Y
authors.lastname: Yuan
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.forename: Lili
authors.initials: L
authors.lastname: Tan
authors.forename: Shurui
authors.initials: S
authors.lastname: Chen
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.forename: Xifan
authors.initials: X
authors.lastname: Mei
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D000818:Animals; D001673:Biodegradation, Environmental / Q000187:drug effects; D001706:Biopsy; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D005260:Female; D007150:Immunohistochemistry; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D010006:Osteoblasts / Q000187:drug effects / Q000473:pathology; D010024:Osteoporosis / Q000378:metabolism*; D010052:Ovariectomy; D019919:Prosthesis Implantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling
chemical_list: D000497:Alloys; D055396:Bone Morphogenetic Protein 2; C586533:Mg-Al-Zn-Mn-Si-Cu alloy
keywords: BMP-2; Magnesium alloy; Osteoblast; Osteoporosis