title: [Inter-individual and intra-individual pharmacokinetic variability during teicoplanin therapy in geriatric patients].
abstract: OBJECTIVE
  The authors had for aim to assess the inter- and intra-individual variability of teicoplanin pharmacokinetic parameters in geriatric patients.
  
  
  METHODS
  A cohort of 90 geriatric patients, treated with teicoplanin, was used to build two models describing the pharmacokinetics of teicoplanin, at the beginning and at the end of treatment respectively.
  
  
  RESULTS
  The inter- and intra-individual variability of parameters were important as shown respectively by the coefficients of variation of pharmacokinetic parameters ranging from 125 to 694% and the half-life change during the treatment (by a factor of three to more than 30) for 60% of patients.
  
  
  CONCLUSIONS
  The results revealed that elderly patients presented significant variability, which was only partly explained by the renal function. Therapeutic monitoring of teicoplanin in geriatric patients should be undertaken at the end of the loading dose and repeatedly during the maintenance phase to prevent over- or underexposure.
authors.affiliation: Service pharmaceutique, hôpital Antoine-Charial, Hospices Civils de Lyon, groupement hospitalier de gériatrie, 40, avenue de la Table-de-Pierre, 69340 Francheville, France. uhart.mathieu@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Uhart
authors.forename: B
authors.initials: B
authors.lastname: Leroy
authors.forename: A
authors.initials: A
authors.lastname: Michaud
authors.forename: P
authors.initials: P
authors.lastname: Maire
authors.forename: L
authors.initials: L
authors.lastname: Bourguignon
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015331:Cohort Studies; D016903:Drug Monitoring; D014644:Genetic Variation; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000502:physiology; D008954:Models, Biological; D012189:Retrospective Studies; D017334:Teicoplanin / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin
keywords: Antibiotic monitoring; Dosage d’antibiotiques; Geriatrics; Gériatrie; Teicoplanin; Teicoplanine