title: Automatic sleep staging using empirical mode decomposition, discrete wavelet transform, time-domain, and nonlinear dynamics features of heart rate variability signals.
abstract: The conventional method for sleep staging is to analyze polysomnograms (PSGs) recorded in a sleep lab. The electroencephalogram (EEG) is one of the most important signals in PSGs but recording and analysis of this signal presents a number of technical challenges, especially at home. Instead, electrocardiograms (ECGs) are much easier to record and may offer an attractive alternative for home sleep monitoring. The heart rate variability (HRV) signal proves suitable for automatic sleep staging. Thirty PSGs from the Sleep Heart Health Study (SHHS) database were used. Three feature sets were extracted from 5- and 0.5-min HRV segments: time-domain features, nonlinear-dynamics features and time-frequency features. The latter was achieved by using empirical mode decomposition (EMD) and discrete wavelet transform (DWT) methods. Normalized energies in important frequency bands of HRV signals were computed using time-frequency methods. ANOVA and t-test were used for statistical evaluations. Automatic sleep staging was based on HRV signal features. The ANOVA followed by a post hoc Bonferroni was used for individual feature assessment. Most features were beneficial for sleep staging. A t-test was used to compare the means of extracted features in 5- and 0.5-min HRV segments. The results showed that the extracted features means were statistically similar for a small number of features. A separability measure showed that time-frequency features, especially EMD features, had larger separation than others. There was not a sizable difference in separability of linear features between 5- and 0.5-min HRV segments but separability of nonlinear features, especially EMD features, decreased in 0.5-min HRV segments. HRV signal features were classified by linear discriminant (LD) and quadratic discriminant (QD) methods. Classification results based on features from 5-min segments surpassed those obtained from 0.5-min segments. The best result was obtained from features using 5-min HRV segments classified by the LD classifier. A combination of linear/nonlinear features from HRV signals is effective in automatic sleep staging. Moreover, time-frequency features are more informative than others. In addition, a separability measure and classification results showed that HRV signal features, especially nonlinear features, extracted from 5-min segments are more discriminative than those from 0.5-min segments in automatic sleep staging.
authors.affiliation: Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.
authors.forename: Farideh
authors.initials: F
authors.lastname: Ebrahimi
authors.forename: Seyed-Kamaledin
authors.initials: SK
authors.lastname: Setarehdan
authors.forename: Jose
authors.initials: J
authors.lastname: Ayala-Moyeda
authors.forename: Homer
authors.initials: H
authors.lastname: Nazeran
mesh_terms: D000465:Algorithms; D000704:Analysis of Variance; D016208:Databases, Factual; D004562:Electrocardiography / Q000706:statistics & numerical data; D004569:Electroencephalography / Q000706:statistics & numerical data; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D017711:Nonlinear Dynamics; D017286:Polysomnography / Q000706:statistics & numerical data*; D012894:Sleep Stages / Q000502:physiology*; D058067:Wavelet Analysis
keywords: Automatic sleep staging; Discrete wavelet transform (DWT); Discriminant classifiers; Empirical mode decomposition (EMD); Heart rate variability; Nonlinear dynamics analysis