title: Oral chemoprevention with acetyl salicylic Acid, vitamin D and calcium reduces the risk of tobacco carcinogen-induced bladder tumors in mice.
abstract: Bladder cancer is a common urological malignancy with high recurrence rate, which may be reduced by chemoprevention. The aim was to evaluate chemoprevention in a mouse model of tobacco carcinogen-induced bladder tumors. A total of 60 A/J mice were randomized to normal diet, diet with low calcium, and diet with chemoprevention (acetyl salicylic acid, 1-alpha 25(OH)2-vitamin D3 and calcium). There were significantly fewer tumors (0 (0-0) vs. 0 (0-2), p = .045) and fewer animals with tumors (0/20 vs. 5/20, p = .045) in the chemoprevention group compared with controls. Thus, chemoprevention diet effectively reduced the tumor promoting effect of tobacco carcinogens in the mouse bladder.
authors.affiliation: Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark. hcpommergaard@gmail.com
authors.forename: H C
authors.initials: HC
authors.lastname: Pommergaard
authors.forename: J
authors.initials: J
authors.lastname: Burcharth
authors.forename: J
authors.initials: J
authors.lastname: Rosenberg
authors.forename: H
authors.initials: H
authors.lastname: Raskov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage*; D002118:Calcium / Q000008:administration & dosage*; D002136:Calcium, Dietary / Q000008:administration & dosage*; D002273:Carcinogens / Q000633:toxicity; D004195:Disease Models, Animal; D051379:Mice; D012907:Smoking / Q000009:adverse effects; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D002136:Calcium, Dietary; D002273:Carcinogens; D014807:Vitamin D; D001241:Aspirin; D002118:Calcium