title: In vitro susceptibility of dermatophytes isolated from patients with end-stage renal disease: a case-control study.
abstract: Although the therapeutic efficacy of antifungals is well known for dermatophytosis in general population, limited data exist for patients with chronic kidney disease. The objectives of this study were to determine the dermatophyte species causing infection in patients with end-stage renal disease (ESRD) and in vitro susceptibility of isolated dermatophytes to antifungals. A total of 87 patients with ESRD who undergoing haemodialysis and 105 patients with normal renal function suspected with dermatophytosis were included. Skin scrapings or nail clippings were examined by direct microscopy and cultured on Sabouraud agar. In vitro antifungal susceptibility tests were performed using a broth microdilution method. Dermatophyte infections were identified in 32.2% of haemodialysis patients and in 29.5% of controls (P > 0.05). In both groups, Trichophyton rubrum was the most frequently isolated. Mean MIC values of the all studied antifungals for all of isolated dermatophyte strains from patients with ESRD were similar to those obtained in control group (P > 0.05). Terbinafine (TBF) had the lowest mean MIC values for all tested dermatophytes in both groups. We consider that TBF should be the treatment of choice for dermatophytosis in patients with chronic kidney disease, but the dose should be adjusted according to creatinine clearance and should be monitored for side effects.
authors.affiliation: Department of Dermatology, Transilvania University, Brasov, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Irimie
authors.forename: Alexandru
authors.initials: A
authors.lastname: Tătaru
authors.forename: Alexandru
authors.initials: A
authors.lastname: Oantă
authors.forename: Marius
authors.initials: M
authors.lastname: Moga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D003404:Creatinine / Q000378:metabolism; D003881:Dermatomycoses / Q000175:diagnosis* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use; D006435:Renal Dialysis; D000077291:Terbinafine; D014249:Trichophyton / Q000187:drug effects* / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D003404:Creatinine; D000077291:Terbinafine
keywords: Dermatophyte; antifungals; chronic kidney disease; in vitro susceptibility