title: Genetic polymorphisms of XRCC1 gene and susceptibility to gastric cancer in Chinese Han population.
abstract: This study aims to evaluate whether the c.1471G > A and c.1686C > G genetic polymorphisms of XRCC1 gene influencing gastric cancer susceptibility. A total of 813 subjects with Chinese Han ethnicity were enrolled. Our data suggest that the allele and genotype frequencies are significantly different from gastric cancer patients with cancer-free controls. We find that c.1471G > A and c.1686C > G genetic polymorphisms statistically increase the risk of gastric cancer. Our findings indicate these two genetic polymorphisms are related with the susceptibility to gastric cancer, and could be used as molecular markers for detecting gastric cancer in Chinese Han ethnicity.
authors.affiliation: Department of General Surgery, Changhai Hospital, The Second Military Medical University , Shanghai , People's Republic of China.
authors.forename: Zhengmao
authors.initials: Z
authors.lastname: Lu
authors.forename: Tianhang
authors.initials: T
authors.lastname: Luo
authors.forename: Mingming
authors.initials: M
authors.lastname: Nie
authors.forename: Jianwei
authors.initials: J
authors.lastname: Bi
authors.forename: Chongwei
authors.initials: C
authors.lastname: Ke
authors.forename: Xuchao
authors.initials: X
authors.lastname: Xue
authors.forename: Liye
authors.initials: L
authors.lastname: Ma
authors.forename: Guoen
authors.initials: G
authors.lastname: Fang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human