title: [The child's brain: normal (unaltered) development and development altered by perinatal injury].
abstract: In this study we analyse some of the morphological and functional aspects of normal and altered development (the latter due to perinatal injury) in the child's brain. Both normal and altered development are developmental processes that progressively interconnect the different regions. The neuropathological development of subpial and periventricular haemorrhages, as well as that of white matter infarct, are analysed in detail. Any kind of brain damage causes a local lesion with possible remote repercussions. All the components (neurons, fibres, blood capillaries and neuroglias) of the affected region undergo alterations. Those that are destroyed are eliminated by the inflammatory process and those that survive are transformed. The pyramidal neurons with amputated apical dendrites are transformed and become stellate cells, the axonal terminals and those of the radial glial cells are regenerated and the region involved is reinnervated and revascularised with an altered morphology and function (altered local corticogenesis). The specific microvascular system of the grey matter protects its neurons from infarction of the white matter. Although it survives, the grey matter is left disconnected from the afferent and efferent fibres, amputated by the infarct with alterations affecting its morphology and possibly its functioning (altered local corticogenesis). Any local lesion can modify the morphological and functional development of remote regions that are functionally interconnected with it (altered remote corticogenesis). We suggest that any local brain injury can alter the morphology and functioning of the regions that are morphologically and functionally interconnected with it and thus end up affecting the child's neurological and psychological development. These changes can cross different regions of the brain (epileptic auras) and, if they eventually reach the motor region, will give rise to the motor storm that characterises epilepsy.
authors.affiliation: Dartmouth Medical School, NH 03755 Hanover, EE.UU.
authors.forename: Miguel
authors.initials: M
authors.lastname: Marín-Padilla
mesh_terms: D000293:Adolescent; D000818:Animals; D001921:Brain / Q000166:cytology / Q000196:embryology / Q000254:growth & development* / Q000473:pathology; D001925:Brain Damage, Chronic / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000473:pathology; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology; D006652:Histological Techniques; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000473:pathology; D008322:Mammals / Q000196:embryology / Q000254:growth & development; D008578:Meninges / Q000473:pathology; D009474:Neurons / Q000145:classification / Q000166:cytology; D013194:Staining and Labeling