title: Effects of polymorphisms in nucleotide excision repair genes on glioma risk in a Chinese population.
abstract: We performed a case-control study to assess the relationship between six single nucleotide polymorphisms (SNPs) of xeroderma pigmentosum complementation group F (XPF) on glioma risk in a Chinese population. The six SNPs were genotyped in 330 glioma cases and 652 cancer-free controls using a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). Rs1800067 did not follow the Hardy-Weinberg equilibrium in the control group, and the genotype distributions differed significantly between the two groups for SNPs rs1800067 and rs2276466. For rs1800067, the variant genotype T/T was strongly associated with an increased risk of glioma when compared with the A/A genotype (OR=3.77, 95% CI=2.38-6.01). Individuals with the rs1800067 G allele had a relatively high risk of glioma in a dominant model (OR=3.47, 95% CI=2.26-5.37). The rs2276466 G/G genotype was significantly associated with a moderate increased risk of glioma (OR=1.82, 95% CI=1.10-3.02) in a codominant model, and variation of rs25489 was associated with a 1.31- and 1.78-fold glioma risk in dominant and recessive models, respectively. Our study is the first to identify polymorphisms in rs1800067 and rs2276466 as correlated with glioma susceptibility.
authors.affiliation: Department of Neurosurgery, Fourth Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Zheng-Kai
authors.initials: ZK
authors.lastname: Shao
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000235:genetics*; D002681:China; D005260:Female; D005799:Genes, Dominant; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014983:Xeroderma Pigmentosum / Q000235:genetics*
keywords: BER; CI; DSBR; Glioma; HRR; ICL; IR; MMR; NER; OR; PCR; SBE; SNPs; Single nucleotide polymorphisms; XPF; Xeroderma pigmentosum complementation group F; base-excision repair; credibility intervals; double strand break repair; homologous recombination repair; interstrand cross-links; ionizing radiation; mismatch repair; nucleotide excision repair; odds ratio; polymerase chain reaction; single base extension; single nucleotide polymorphisms; xeroderma pigmentosum complementation group F