title: EEG characterization of audiogenic seizures in the hamster strain GASH:Sal.
abstract: The study was performed to characterize GASH:SAL audiogenic seizures as true epileptic activity based on electroencephalographic markers acquired with a wireless implanted radiotelemetry system. We analyzed cortical EEG patterns synchronized with video recordings of convulsive behavior of the GASH:Sal hamster following an acoustic stimulus. All GASH:Sal presented archetypal motor symptoms comparable to current animal models of generalized tonic-clonic epilepsy. Seizures consisted of an initial bout of wild running, followed by opisthotonus, tonic-clonic convulsions, tonic limb extension, and terminated in postictal depression. EEG patterns correlated with behavior and displayed phase appropriate spike-wave complexes, low-amplitude desynchronized activity, and high frequency large-amplitude peaks. Our results confirm that electroencephalographic profiles of the audiogenic seizures of the hamster GASH:Sal are parallel to EEG patterns of other animal models of generalized tonic-clonic seizures. Therefore, this animal may serve as an appropriate model for epilepsy research.
authors.affiliation: Instituto de Neurociencias de Castilla y León/IBSAL, C/ Pintor Fernando Gallego, n° 1, 37007 Salamanca, Spain; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Room 2-34, Miami, FL 33136, USA.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Carballosa-Gonzalez
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Muñoz
authors.forename: Tomás
authors.initials: T
authors.lastname: López-Alburquerque
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Pardal-Fernández
authors.forename: Eduardo
authors.initials: E
authors.lastname: Nava
authors.forename: Carlos
authors.initials: C
authors.lastname: de Cabo
authors.forename: Consuelo
authors.initials: C
authors.lastname: Sancho
authors.forename: Dolores E
authors.initials: DE
authors.lastname: López
mesh_terms: D000818:Animals; D016477:Artifacts; D002540:Cerebral Cortex / Q000503:physiopathology; D006224:Cricetinae; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D020195:Epilepsy, Reflex / Q000235:genetics* / Q000503:physiopathology*; D004830:Epilepsy, Tonic-Clonic / Q000503:physiopathology; D005583:Fourier Analysis; D007700:Kinetics; D008647:Mesocricetus; D009043:Motor Activity / Q000502:physiology; D009068:Movement / Q000502:physiology; D012640:Seizures / Q000503:physiopathology; D013686:Telemetry
keywords: Animal model of epilepsy; Electroencephalography; Radiotelemetry recordings; Video-EEG