title: Gene expression profiling of murine T-cell lymphoblastic lymphoma identifies deregulation of S-phase initiating genes.
abstract: In a search for genes and pathways implicated in T-cell lymphoblastic lymphoma (T-LBL) development, we used a murine lymphoma model, where mice of the NMRI-inbred strain were inoculated with murine leukemia virus mutants. The resulting tumors were analyzed by integration analysis and global gene expression profiling to determine the effect of the retroviral integrations on the nearby genes, and the deregulated pathways in the tumors. Gene expression profiling identified increased expression of genes involved in the minichromosome maintenance and origin of recognition pathway as well as downregulation in negative regulators of G1/S transition, indicating increased S-phase initiation in murine T-LBLs.
authors.affiliation: Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. magdalena_dabrowska@ymail.com
authors.forename: Magdalena Julia
authors.initials: MJ
authors.lastname: Dabrowska
authors.forename: Ditte
authors.initials: D
authors.lastname: Ejegod
authors.forename: Louise Berkhoudt
authors.initials: LB
authors.lastname: Lassen
authors.forename: Hans Erik
authors.initials: HE
authors.lastname: Johnsen
authors.forename: Matthias
authors.initials: M
authors.lastname: Wabl
authors.forename: Finn Skou
authors.initials: FS
authors.lastname: Pedersen
authors.forename: Karen
authors.initials: K
authors.lastname: Dybkær
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D018816:Genes, cdc; D009052:Leukemia Virus, Murine / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000821:virology; D016196:S Phase / Q000235:genetics*; D016662:Virus Integration
keywords: Gene expression Profiling; Insertional mutagenesis; MLV; Mouse model; SL3-3; T-LBL; T-cell lymphoblastic lymphoma
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