title: Cisplatin chemotherapy induces odor perception changes in bronchial cancer patients.
abstract: A study of olfactory function was performed in 15 bronchial cancer patients receiving cisplatin and 15 control subjects. Whereas odor detection and odor identification abilities were not influenced by the administration of cisplatin, a decrease in pleasantness was observed only for food odors, and not for non-food odors. Taken as a whole, these findings suggest that cisplatin therapy in bronchial cancer patients impairs the pleasure of perceived food odors, which may account for disturbances in food intake and quality of life in this population.
authors.affiliation: CNRS, UMR5292, INSERM U1028, Lyon Neuroscience Research Center, University Lyon, F-69000, France. Electronic address: uline.joussain@olfac.univ-lyon1.fr.
authors.forename: P
authors.initials: P
authors.lastname: Joussain
authors.forename: A
authors.initials: A
authors.lastname: Giboreau
authors.forename: M
authors.initials: M
authors.lastname: Fontas
authors.forename: M
authors.initials: M
authors.lastname: Laville
authors.forename: T
authors.initials: T
authors.lastname: Hummel
authors.forename: P J
authors.initials: PJ
authors.lastname: Souquet
authors.forename: M
authors.initials: M
authors.lastname: Bensafi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000188:drug therapy*; D016022:Case-Control Studies; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D009812:Odorants; D000857:Olfaction Disorders / Q000139:chemically induced*; D011788:Quality of Life; D012903:Smell / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: Bronchial cancer; Chemotherapy; Cisplatin; Food; Olfaction; pleasantness