title: [Expression of urea transporters in sweat gland tissue of normal subjects and uremic patients].
abstract: OBJECTIVE
  To explore the expression of urea transporters (UTs) in the skin and sweat glands of normal subjects and patients with uremia.
  
  
  METHODS
  Abdominal skin biopsy samples of patients with uremia and normal patients and apocrine sweat gland tissue from patients with bromidrosis were examined for the expression of UTs using immunohistochemistry and fluorescence immunoassay for quantitative analysis.
  
  
  RESULTS
  Both UT-A1 and UT-B1 proteins were expressed in the skin basal cell layer, eccrine sweat gland and apocrine sweat gland tissues. In uremic patients, N-UT-A1 and UT-B1 expressions were significantly higher than those in the control (P<0.05) but C-UT-A1 expression was similar (P>0.05).
  
  
  CONCLUSIONS
  UTs are expressed in human skin basal cell layer, eccrine sweat gland and apocrine sweat gland tissues, and their expressions are upregulated in uremic patients.
authors.affiliation: Xi'an Jiaotong University College of Medicine, Xi'an Jiaotong University, Xi'an, China. deborahjing0110@126.com
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Liyi
authors.initials: L
authors.lastname: Xie
authors.forename: Aiping
authors.initials: A
authors.lastname: Yin
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D013545:Sweat Glands / Q000166:cytology / Q000378:metabolism*; D014511:Uremia / Q000378:metabolism*; D000096982:Urea Transporters
chemical_list: D026901:Membrane Transport Proteins; D000096982:Urea Transporters