title: Transport of macrocyclic compounds across phospholipid bilayers by umbrella-rotaxanes.
abstract: We report the synthesis and assembly of umbrella-rotaxanes with transmembrane transport properties. We describe their amphomorphism and validate their ability to penetrate and cross phospholipid bilayers. Furthermore we present the strategy to release the macrocyclic compound by enzymatic cleavage inside egg yolk phosphatidylcholine (EYPC) liposomes.
authors.affiliation: Department of Chemistry-Université de Montréal, 2900 Edouard Montpetit, CP 6128 Succursalle Centre ville, Montréal, QC, Canada H3C3J7.
authors.forename: Christine
authors.initials: C
authors.lastname: Chhun
authors.forename: Josée
authors.initials: J
authors.lastname: Richard-Daniel
authors.forename: Julie
authors.initials: J
authors.lastname: Kempf
authors.forename: Andreea R
authors.initials: AR
authors.lastname: Schmitzer
mesh_terms: D008051:Lipid Bilayers / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D047028:Macrocyclic Compounds; D010743:Phospholipids; D043862:Rotaxanes