title: Comparison of clinical characteristics and survival after surgery in patients with non-B and non-C hepatocellular carcinoma and hepatitis virus-related hepatocellular carcinoma.
abstract: OBJECTIVE
  We compared clinicopathologic data and long-term clinical outcomes among patients with non-B and non-C hepatocellular carcinoma (NBNC-HCC) who underwent curative resection (group A, n=129), those with hepatitis B virus-related HCC (group B, n=62) and those with hepatitis C virus-related HCC (group C, n=284).
  
  
  METHODS
  Clinicopathologic characteristics and cumulative overall survival (OS) and recurrence-free survival (RFS) after curative resection were compared among the three groups.
  
  
  RESULTS
  The proportion of patients with non-liver cirrhosis (LC) or diabetes mellitus in group A was significantly higher than that in group B or group C. The mean maximum tumor size in group A was significantly larger than that of group B or group C. Cumulative 3-year OS rates after resection were 76% in group A, 79% in group B and 72% in group C (A vs. B, P=0.638; A vs. C, P=0.090; B vs. C, P=0.091; overall significance, P=0.088). The corresponding RFS rates after resection were 38% in group A, 36% in group B and 36% in group C (A vs. B, P=0.528; A vs. C, P=0.281; B vs. C, P=0.944; overall significance, P=0.557). In subgroup analyses in patients with LC, in those without LC and in those who satisfied the Milan criteria, similar results were obtained, i.e., the difference among the three groups did not reach significance in terms of OS and RFS.
  
  
  CONCLUSIONS
  Long-term clinical outcomes in patients NBNC-HCC after curative resection were comparable to those in patients with hepatitis virus-related HCC after curative resection.
authors.affiliation: 1. Departments of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka 543-0027, Japan;
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Arimoto
authors.forename: Tomoko
authors.initials: T
authors.lastname: Wakasa
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kita
authors.forename: Toru
authors.initials: T
authors.lastname: Kimura
authors.forename: Yukio
authors.initials: Y
authors.lastname: Osaki
keywords: Non-B and non-C hepatocellular carcinoma; overall survival; prognostic factor.; recurrence-free survival; surgery
references.citation: Jpn J Surg. 1989 Jan;19(1):98-129
references.pmid: 2659865
references.citation: Am J Surg. 2012 Sep;204(3):300-7
references.pmid: 22591698
references.citation: Gastroenterology. 2012 May;142(6):1264-1273.e1
references.pmid: 22537432
references.citation: Cancer. 2000 Feb 15;88(4):761-9
references.pmid: 10679644
references.citation: Intervirology. 2007;50(1):24-31
references.pmid: 17164554
references.citation: Eur J Gastroenterol Hepatol. 2011 Sep;23(9):787-93
references.pmid: 21730869
references.citation: J Gastroenterol Hepatol. 2011 Sep;26(9):1417-24
references.pmid: 21884248
references.citation: Ann Surg. 2009 Feb;249(2):195-202
references.pmid: 19212170
references.citation: Br J Surg. 1997 Nov;84(11):1525-31
references.pmid: 9393270
references.citation: Semin Liver Dis. 1986 Aug;6(3):259-66
references.pmid: 3022387
references.citation: Hepatology. 2012 Jun;55(6):1809-19
references.pmid: 22183968
references.citation: J Gastroenterol. 2009;44(6):635-42
references.pmid: 19387533
references.citation: Hepatology. 2009 Mar;49(3):851-9
references.pmid: 19115377
references.citation: Ann Surg. 2011 Jul;254(1):108-13
references.pmid: 21527845
references.citation: Oncogene. 2011 Apr 28;30(17):1969-83
references.pmid: 21258404
references.citation: J Clin Gastroenterol. 2013 Apr;47(4):359-66
references.pmid: 23090049
references.citation: Clin Microbiol Infect. 2009 Nov;15(11):964-70
references.pmid: 19874379
references.citation: J Viral Hepat. 2007 Dec;14(12):821-9
references.pmid: 18070284
references.citation: Hepatol Res. 2007 Sep;37 Suppl 2:S95-S100
references.pmid: 17877503
references.citation: Scand J Surg. 2011;100(1):22-9
references.pmid: 21482502
references.citation: Oncol Rep. 2010 May;23(5):1317-23
references.pmid: 20372846
references.citation: Cancer. 2013 Jan 1;119(1):126-35
references.pmid: 22736338
references.citation: Int J Oncol. 2012 Sep;41(3):903-9
references.pmid: 22692851
references.citation: Clin Gastroenterol Hepatol. 2011 Jul;9(7):617-23.e1
references.pmid: 21459158
references.citation: Hepatol Res. 2014 Mar;44(3):302-12
references.pmid: 23607614
references.citation: Oncology. 2010 Jul;78 Suppl 1:113-24
references.pmid: 20616593
references.citation: Hepatology. 2010 May;51(5):1820-32
references.pmid: 20432259
references.citation: Hepatology. 2005 Nov;42(5):1208-36
references.pmid: 16250051
references.citation: World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253
references.pmid: 11234459
references.citation: J Gastroenterol. 2013 Aug;48(8):951-65
references.pmid: 23065022
references.citation: Hepatol Res. 2011 Aug;41(8):711-21
references.pmid: 21682827