title: The atypical lipopolysaccharide of Francisella.
abstract: Bacterial lipopolysaccharides (LPSs) are ubiquitous molecules that are prominent components of the outer membranes of most gram-negative bacteria. Genetic and structural characterizations of Francisella LPS have revealed substantial differences when compared to more commonly studied LPSs of the Enterobacteriaceae. This review discusses both the general characteristics and the unusual features of Francisella LPS.
authors.affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States.
authors.forename: Nihal A
authors.initials: NA
authors.lastname: Okan
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Kasper
mesh_terms: D005603:Francisella / Q000378:metabolism; D008050:Lipid A / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D008070:Lipopolysaccharides / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D019081:O Antigens / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism
chemical_list: D008050:Lipid A; D008070:Lipopolysaccharides; D019081:O Antigens
keywords: 2,4-diacetamido-2,4,6-trideoxy-d-glucose; 2-acetamido-2,6-dideoxy-d-glucose; 2-acetamido-2-deoxy-d-galacturonamide; 3-deoxy-d-manno-octulosonic acid; 4,6-dideoxy-4-formamido-d-glucose; Francisella tularensis; GalNAcAN; Kdo; Kdo hydrolase; LPS; Lipid A; Lipopolysachharide; O-antigen; Qui2NAc4NAc; Qui4NFm; QuiNAc; Structure; lipopolysachharide
references.citation: PLoS One. 2010 Jul 06;5(7):e11060
references.pmid: 20625403
references.citation: Infect Immun. 2007 May;75(5):2591-602
references.pmid: 17296751
references.citation: J Bacteriol. 1999 Apr;181(8):2648-51
references.pmid: 10198035
references.citation: FEMS Microbiol Immunol. 1992 Oct;5(4):201-10
references.pmid: 1419118
references.citation: Annu Rev Microbiol. 2006;60:167-85
references.pmid: 16704343
references.citation: Annu Rev Biochem. 2006;75:39-68
references.pmid: 16756484
references.citation: J Bacteriol. 1951 May;61(5):557-69
references.pmid: 14832199
references.citation: Nat Rev Microbiol. 2005 Jan;3(1):36-46
references.pmid: 15608698
references.citation: Infect Immun. 2004 Sep;72(9):5340-8
references.pmid: 15322031
references.citation: Mol Microbiol. 2010 Nov;78(4):820-36
references.pmid: 20662782
references.citation: J Am Soc Mass Spectrom. 2007 Jun;18(6):1080-92
references.pmid: 17446084
references.citation: Cell Microbiol. 2011 Oct;13(10):1586-600
references.pmid: 21883803
references.citation: Innate Immun. 2014 Jan;20(1):88-103
references.pmid: 23729477
references.citation: J Biol Chem. 2004 Nov 19;279(47):49470-8
references.pmid: 15339914
references.citation: Infect Immun. 2011 Feb;79(2):581-94
references.pmid: 21078861
references.citation: Infect Immun. 2007 Jan;75(1):371-8
references.pmid: 17074846
references.citation: J Biol Chem. 2010 Sep 3;285(36):27839-49
references.pmid: 20605777
references.citation: Mol Microbiol. 2010 Nov;78(4):837-52
references.pmid: 20659292
references.citation: J Biol Chem. 1972 Jun 25;247(12):3973-86
references.pmid: 4624447
references.citation: Clin Microbiol Rev. 2002 Oct;15(4):631-46
references.pmid: 12364373
references.citation: Biochemistry. 2006 Dec 5;45(48):14427-40
references.pmid: 17128982
references.citation: Biochemistry. 2011 Dec 20;50(50):10941-50
references.pmid: 22091710
references.citation: J Clin Microbiol. 1989 Jul;27(7):1601-8
references.pmid: 2671019
references.citation: PLoS Pathog. 2008 Feb 8;4(2):e24
references.pmid: 18266468
references.citation: Anal Chem. 2007 Feb 1;79(3):1034-42
references.pmid: 17263332
references.citation: Vaccine. 2006 Feb 13;24(7):989-96
references.pmid: 16257097
references.citation: Mol Microbiol. 1996 May;20(4):867-74
references.pmid: 8793882
references.citation: J Lipid Res. 2009 Apr;50 Suppl:S103-8
references.pmid: 18974037
references.citation: J Biol Chem. 2010 Nov 5;285(45):34330-6
references.pmid: 20801884
references.citation: Carbohydr Res. 2004 Feb 25;339(3):649-54
references.pmid: 15013402
references.citation: Biochemistry. 2009 Feb 17;48(6):1173-82
references.pmid: 19166326
references.citation: J Med Microbiol. 2005 Jul;54(Pt 7):693-695
references.pmid: 15947437
references.citation: PLoS One. 2010 Jul 29;5(7):e11857
references.pmid: 20686600
references.citation: Infect Immun. 2006 Dec;74(12):6730-8
references.pmid: 16982824
references.citation: Proc Natl Acad Sci U S A. 2012 May 29;109(22):8716-21
references.pmid: 22586119
references.citation: Ann N Y Acad Sci. 2007 Jun;1105:202-18
references.pmid: 17395723
references.citation: Immunology. 2012 Jul;136(3):352-60
references.pmid: 22486311
references.citation: Proc Natl Acad Sci U S A. 1983 Mar;80(5):1159-63
references.pmid: 6338498
references.citation: Front Microbiol. 2010 Nov 19;1:129
references.pmid: 21687776
references.citation: J Med Microbiol. 2003 Oct;52(Pt 10):845-851
references.pmid: 12972577
references.citation: Annu Rev Biochem. 2002;71:635-700
references.pmid: 12045108
references.citation: Innate Immun. 2012 Apr;18(2):268-78
references.pmid: 21709054
references.citation: Mol Microbiol. 2012 Nov;86(3):611-27
references.pmid: 22966934
references.citation: Eur J Biochem. 2002 Dec;269(24):6112-8
references.pmid: 12473106
references.citation: Infect Immun. 2007 Nov;75(11):5518-31
references.pmid: 17724076
references.citation: J Am Chem Soc. 2012 Aug 29;134(34):14255-62
references.pmid: 22867268
references.citation: Carbohydr Res. 2004 Jun 22;339(9):1643-8
references.pmid: 15183739
references.citation: Biochemistry. 2010 Jun 8;49(22):4565-7
references.pmid: 20446753
references.citation: J Biol Chem. 2000 Nov 10;275(45):34954-62
references.pmid: 10952982
references.citation: mBio. 2013 Feb 12;4(1):e00638-12
references.pmid: 23404403
references.citation: J Immunol. 2006 Jun 1;176(11):6888-99
references.pmid: 16709849
references.citation: Biochemistry. 2012 Jul 17;51(28):5684-94
references.pmid: 22747335
references.citation: Infect Immun. 2007 Jan;75(1):536-41
references.pmid: 17030571
references.citation: J Biol Chem. 2006 Apr 7;281(14):9321-30
references.pmid: 16467300
references.citation: Carbohydr Res. 1991 Jul 30;214(2):289-97
references.pmid: 1769021
references.citation: J Endotoxin Res. 2006;12(4):205-23
references.pmid: 16953973