title: Prognostic significance of extracellular matrix degrading enzymes-cathepsin L and matrix metalloproteases-2 [MMP-2] in human pancreatic cancer.
abstract: In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor tissues examined. Staining intensity of cathepsin L was significantly higher in the tumor stroma compared to tumor epithelium while MMP-2 staining showed no such difference. Both proteases showed correlation with some of the clinicopathological parameters but only cathepsin L expression in tumor epithelium predicted a poor prognosis for the disease.
authors.affiliation: Department of Gastroenterology & Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Singh
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Das
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Datta Gupta
authors.forename: Peush
authors.initials: P
authors.lastname: Sahni
authors.forename: R M
authors.initials: RM
authors.lastname: Pandey
authors.forename: Surabhi
authors.initials: S
authors.lastname: Gupta
authors.forename: Shyam S
authors.initials: SS
authors.lastname: Chauhan
authors.forename: Anoop
authors.initials: A
authors.lastname: Saraya
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000401:mortality; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D056668:Cathepsin L / Q000032:analysis* / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000032:analysis* / Q000096:biosynthesis; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000201:enzymology* / Q000401:mortality; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D014408:Biomarkers, Tumor; D056668:Cathepsin L; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2