title: Has the circulating permeability factor in primary FSGS been found?
abstract: A circulating permeability factor has long been implicated in the pathogenesis of primary focal segmental glomerulosclerosis (FSGS). Evidence in animal models and now in several cohorts of patients with primary FSGS suggests a role for the soluble urokinase-type plasminogen activator receptor (suPAR) as a biomarker and perhaps as a contributing factor. Confirmation of these findings might lead to new diagnostic and therapeutic strategies for FSGS as well as a better understanding of podocyte dysfunction.
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington 98195, USA. jashleyj@uw.edu
authors.forename: J Ashley
authors.initials: JA
authors.lastname: Jefferson
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Shankland
mesh_terms: D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood*; D006801:Humans; D008297:Male; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*
chemical_list: C524898:PLAUR protein, human; D055293:Receptors, Urokinase Plasminogen Activator
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