title: An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?
abstract: Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SRA), hence promoting tumor progression. We demonstrated that SRA can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.
authors.affiliation: Sir William Dunn School of Pathology; University of Oxford; Oxford, UK.
authors.forename: Claudine
authors.initials: C
authors.lastname: Neyen
authors.forename: Subhankar
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: Siamon
authors.initials: S
authors.lastname: Gordon
authors.forename: Thorsten
authors.initials: T
authors.lastname: Hagemann
keywords: apo A-I mimetic peptide; co-culture; ligand; scavenger receptor; tumor-associated macrophage
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