title: Septins set the stage for Orai1 to bind STIM1 at ER-PM junctions.
abstract: The endoplasmic reticulum (ER) Ca(2+) sensor STIM1 recruits and activates the plasma membrane (PM) Ca(2+) channel Orai1 at ER-PM junctions for store-operated Ca(2+) entry (SOCE). Reporting in Nature, Sharma et al. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding proteins in signaling at ER-PM junctions.
authors.affiliation: Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. jen.liou@utsouthwestern.edu
authors.forename: Jen
authors.initials: J
authors.lastname: Liou
authors.forename: Tobias
authors.initials: T
authors.lastname: Meyer
mesh_terms: D002118:Calcium / Q000378:metabolism*; D006801:Humans; D050778:NFATC Transcription Factors / Q000378:metabolism*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics*; D058112:Septins / Q000378:metabolism*
chemical_list: D050778:NFATC Transcription Factors; D034741:RNA, Small Interfering; D058112:Septins; D002118:Calcium
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