title: Mathematical modeling of glioma therapy using oncolytic viruses.
abstract: Diffuse infiltrative gliomas are adjudged to be the most common primary brain tumors in adults and they tend to blend in extensively in the brain micro-environment. This makes it difficult for medical practitioners to successfully plan effective treatments. In attempts to prolong the lengths of survival times for patients with malignant brain tumors, novel therapeutic alternatives such as gene therapy with oncolytic viruses are currently being explored. Based on such approaches and existing work, a spatio-temporal model that describes interaction between tumor cells and oncolytic viruses is developed. Conditions that lead to optimal therapy in minimizing cancer cell proliferation and otherwise are analytically demonstrated. Numerical simulations are conducted with the aim of showing the impact of virotherapy on proliferation or invasion of cancer cells and of estimating survival times.
authors.affiliation: Laboratoire Interdisciplinaire des Environnements Continentaux, Universite de Lorraine, CNRS UMR 7360, 8 rue du General Delestraint, 57070 METZ, France. baba-issa.camara@univ-lorraine.fr
authors.forename: Baba Issa
authors.initials: BI
authors.lastname: Camara
authors.forename: Houda
authors.initials: H
authors.lastname: Mokrani
authors.forename: Evans K
authors.initials: EK
authors.lastname: Afenya
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D049109:Cell Proliferation; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein / Q000378:metabolism; D005910:Glioma / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000037:antagonists & inhibitors; D055641:Mathematical Concepts; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D050130:Oncolytic Virotherapy; D011157:Population Dynamics; D049490:Systems Biology
chemical_list: D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D020930:MAP Kinase Kinase Kinases