title: Explore the influence of BMI in the optimal time of weaning from sequential mechanical ventilation for severity chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  To study the clinical effect of body mass index (BMI) in the optimal time of weaning from sequential invasive-noninvasive mechanical ventilation (MV) by treating severity chronic obstructive pulmonary disease (COPD) patients.
  
  
  METHODS
  94 patients with severity COPD were divided into the control group (BMI<21) and the study group (BMI>21). These two groups were treated by similar symptomatic therapies such as mechanical ventilation, antibacterial, antispasmodic, relieving asthma, antitussive, expectorant, correction of electrolyte imbalance and acid-base balance disorders, strengthen nutritional support, etc.
  
  
  RESULTS
  Compared with the control group, the study group had shorter duration of invasive mechanical ventilation, non-invasive mechanical ventilation time, total mechanical ventilation time, total hospital stay (P<0.01). There are significant differences between these two groups in re-intubation rate, VAP occurred in the number of case, hospital mortality rate in 28 days (P<0.05).
  
  
  CONCLUSIONS
  It is difficult to wean successfully from sequential mechanical ventilation for severity COPD patients (BMI<21), so BMI as one of important reference index can be used to estimate the optimal time for weaning from sequential mechanical ventilation for severity COPD patients.
authors.affiliation: Emergency Department of PLA NO.155 Central Hospital, Kaifeng 475003, China.
authors.forename: Sun
authors.initials: S
authors.lastname: Li-dong
authors.forename: Guo
authors.initials: G
authors.lastname: Chang-sheng
authors.forename: Zhao
authors.initials: Z
authors.lastname: Zi-yu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007442:Intubation, Intratracheal; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D053717:Pneumonia, Ventilator-Associated / Q000209:etiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000628:therapy*; D012121:Respiration, Artificial / Q000009:adverse effects; D012720:Severity of Illness Index; D013997:Time Factors; D015300:Ventilator Weaning
references.citation: Zhonghua Jie He He Hu Xi Za Zhi. 2000 Apr;23(4):212-6
references.pmid: 11778207
references.citation: Thorax. 2011 Jan;66(1):66-73
references.pmid: 20980246