title: Cervical squamous cell carcinoma metastatic to placenta.
abstract: A pregnant 29-year-old gravida 4, para 3 woman with Stage IIB cervical cancer was admitted at 33 weeks and 4 days of gestation and delivered a healthy neonate. Her placenta was small but otherwise grossly unremarkable. Microscopic examination revealed metastatic squamous cell carcinoma. An immunohistochemical stain for p16 was positive in the carcinoma cells, supporting metastasis from the cervical tumor. Cervical squamous cell carcinoma metastatic to placenta is very rare. We report a case and discuss metastatic cancer during pregnancy with recommendations for infant follow-up.
authors.affiliation: Department of Pathology, University of Chicago, Chicago, IL 94143-0102, USA.
authors.forename: Nhu Thuy T
authors.initials: NT
authors.lastname: Can
authors.forename: Patricia
authors.initials: P
authors.lastname: Robertson
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Zaloudek
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Gill
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D002584:Cervix Uteri / Q000473:pathology; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009363:Neoplasm Proteins / Q000378:metabolism; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D009363:Neoplasm Proteins