title: A case of cannabinoid hyperemesis syndrome caused by synthetic cannabinoids.
abstract: BACKGROUND
  Cannabinoid hyperemesis syndrome (CHS) was initially described in 2004 and remains an under-recognized clinical entity that occurs in chronic heavy marijuana smokers.
  
  
  METHODS
  We describe the first report of CHS in an abuser of synthetic cannabinoids. CHS is thought to be caused by over-stimulation of the cannabinoid 1 receptor. The synthetic cannabinoids found in K2, Spice, and other commonly abused designer cannabinoids, including those used by our patient (JWH-018, JWH-073, JWH-122, AM-2201, and AM-694), are potent agonists of the cannabinoid 1 receptor.
  
  
  CONCLUSIONS
  Our report suggests that frequent habitual smoking of synthetic cannabinoids can cause cannabinoid hyperemesis syndrome.
authors.affiliation: Department of Emergency Medicine, University of Florida - Jacksonville Health Science Center, Jacksonville, Florida.
authors.forename: Christopher Y
authors.initials: CY
authors.lastname: Hopkins
authors.forename: Brandi L
authors.initials: BL
authors.lastname: Gilchrist
mesh_terms: D000328:Adult; D063386:Cannabinoid Receptor Agonists / Q000009:adverse effects*; D002186:Cannabinoids / Q000009:adverse effects*; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000150:complications; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists; D014839:Vomiting / Q000139:chemically induced*
chemical_list: C571130:CNR1 protein, human; D063386:Cannabinoid Receptor Agonists; D002186:Cannabinoids; D043884:Receptor, Cannabinoid, CB1
keywords: JWH-073; K2; Spice; cannabinoid hyperemesis syndrome; synthetic cannabinoid