title: Role of microRNA-mediated MMP regulation in the treatment and diagnosis of malignant tumors.
abstract: Matrix metalloproteinases (MMPs) play important roles in tumor cell proliferation and apoptosis and contribute to tumor growth, angiogenesis, migration, and invasion primarily via extracellular matrix (ECM) degradation and/or the activation of pre-pro-growth factors. Recently, there has been considerable interest in the posttranscriptional regulation of MMPs via microRNAs (miRs). In this review, we highlight the complicated interactive network comprised of different MMPs and their regulating microRNAs, as well as the ways in which these interactions influence cancer development, including tumor angiogenesis, growth, invasion, and metastasis. Based on the conclusive roles that microRNAs play in the regulation of MMPs during cancer progression, we discuss the potential use of microRNA-mediated MMP regulation in the diagnosis and treatment of tumors from the clinical perspective. In particular, microRNA-mediated MMP regulation may lead to the development of promising new MMP inhibitors that target MMPs more selectively, and this approach may also target multiple molecules in a network, leading to the efficient regulation of distinct biological processes relevant to malignant tumors. A thorough understanding of the mechanisms underlying microRNA-mediated MMP regulation during tumor progression will help to provide new insights into the diagnosis and treatment of malignant tumors.
authors.affiliation: Huzhou Key Laboratory of Molecular Medicine; Huzhou Central Hospital; Huzhou, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital of Huzhou Teachers College; The First People's Hospital of Huzhou; Huzhou, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018450:Disease Progression; D045683:Furin / Q000378:metabolism; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000627:therapeutic use; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D061965:Matrix Metalloproteinase Inhibitors; D035683:MicroRNAs; D045683:Furin; D020782:Matrix Metalloproteinases
keywords: angiogenesis; extracellular matrix; invasion; matrix metalloproteinase; microRNAs; migration; tumor growth
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