title: Full functionalization of the 7-azaindole scaffold by selective metalation and sulfoxide/magnesium exchange.
abstract: Filling positions: 7-Azaindoles are important targets in the pharmaceutical industry. All five carbon positions of the azaindole ring system can be functionalized in a predictable manner starting from the appropriately substituted azaindole 1 by directed metalation and halogen/magnesium and sulfoxide/magnesium exchange. The products are fully substituted azaindoles of type 2.
authors.affiliation: Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München (Germany).
authors.forename: Nadja M
authors.initials: NM
authors.lastname: Barl
authors.forename: Elodie
authors.initials: E
authors.lastname: Sansiaume-Dagousset
authors.forename: Konstantin
authors.initials: K
authors.lastname: Karaghiosoff
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D007211:Indoles / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D012451:Safrole / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: C023422:7-azaindole dimer; D007211:Indoles; D008274:Magnesium; D012451:Safrole; C005746:sulfoxide
keywords: 7-azaindoles; magnesium; metalation; regioselectivity; sulfoxides