title: Haematological acclimation and re-acclimation to hypoxia in the mouse.
abstract: Haematological responses throughout 4 w of initial acclimation (IA) and three paradigms of re-acclimation (RA) to hypoxia (FI(O₂)) were examined in female mice. We hypothesised that (i) haematological responses would be increased during re-exposure, resulting in greater O₂-carrying capacity in RA compared to IA; and (ii) further improvements would occur when abbreviating the de-acclimation period to 1 w (RA↓DA) or extending the IA period to 8 w (RA↑IA). The serum [EPO] response was blunted in all RA groups compared to IA but the resulting reticulocyte response was similar in all experimental groups. The [Hb] response was the same in RA and RA↓DA as in IA but was blunted in RA↑IA due to a reduction in mean corpuscular Hb. The sensitivity of EPO-producing cells appears blunted but the sensitivity of erythroid precursors to EPO is enhanced by recent hypoxic exposure. Erythropoietic regulation is altered during RA in a manner that is dependent on the paradigm of initial exposure.
authors.affiliation: School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Meaghan J
authors.initials: MJ
authors.lastname: MacNutt
authors.forename: James L
authors.initials: JL
authors.lastname: Rupert
authors.forename: A William
authors.initials: AW
authors.lastname: Sheel
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000818:Animals; D001772:Blood Cell Count; D004797:Enzyme-Linked Immunosorbent Assay; D004920:Erythropoiesis / Q000502:physiology; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D000860:Hypoxia / Q000097:blood*; D051379:Mice; D008810:Mice, Inbred C57BL; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D004921:Erythropoietin
keywords: De-acclimation; Erythropoiesis; Erythropoietic control; Hypoxic re-exposure; Intermittent sustained hypoxia