title: Microstructure, mechanical and bio-corrosion properties of Mn-doped Mg-Zn-Ca bulk metallic glass composites.
abstract: The effects of Mn substitution for Mg on the microstructure, mechanical properties, and corrosion behavior of Mg69-xZn27Ca4Mnx (x=0, 0.5 and 1at.%) alloys were investigated using X-ray diffraction, compressive tests, electrochemical treatments, and immersion tests, respectively. Microstructural observations showed that the Mg69Zn27Ca4 alloy was mainly amorphous. The addition of Mn decreases the glass-forming ability, which results in a decreased strength from 545 MPa to 364 MPa. However, this strength is still suitable for implant application. Polarization and immersion tests in the simulated body fluid at 37 °C revealed that the Mn-doped Mg-Zn-Ca alloys have significantly higher corrosion resistance than traditional ZK60 and pure Mg alloys. Cytotoxicity test showed that cell viabilities of osteoblasts cultured with Mn-doped Mg-Zn-Ca alloys extracts were higher than that of pure Mg. Mg68.5Zn27Ca4Mn0.5 exhibits the highest bio-corrosion resistance, biocompatibility and has desirable mechanical properties, which could suggest to be used as biomedical materials in the future.
authors.affiliation: National Engineering Research Center for Magnesium Alloys, College of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China. jfwang@cqu.edu.cn
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Song
authors.initials: S
authors.lastname: Huang
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Wei
authors.forename: Xingfeng
authors.initials: X
authors.lastname: Xi
authors.forename: Kaiyong
authors.initials: K
authors.lastname: Cai
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002152:Calorimetry, Differential Scanning; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003343:Corrosion; D005898:Glass / Q000737:chemistry*; D006859:Hydrogen / Q000032:analysis; D007101:Immersion; D008274:Magnesium / Q000494:pharmacology*; D008422:Materials Testing; D055595:Mechanical Phenomena; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011199:Potentiometry; D051381:Rats; D013052:Spectrometry, X-Ray Emission; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; C586528:Mg68.5Zn27Ca4Mn0.5 alloy; D006859:Hydrogen; D008274:Magnesium
keywords: Amorphous; Biocompatibility; Mechanical properties; Mg-based alloy; Microstructure