title: Stereocontrolled total synthesis of natural products with characteristic molecular structures and biological activities.
abstract: Total synthetic studies on natural products with promising biological profiles, coupled with their intriguing structural features, are described. The target molecules dealt with in this article are five helianane-type sesquiterpenes (heliannuols A, D and K and heliespirones A and C) and three meroterpenes (breviones A, B and C) with allelopathic activity, as well as four cytotoxic polyketides (lasonolide A and aspergillides A, B and C) and two pyrrolidinoindoline alkaloids (physostigmine and psychotrimine) with acetylcholine esterase inhibitory and antibacterial activities.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1–78–1 Sho-machi, Tokushima 770–8505, Japan. shishido@ph.tokushima-u.ac.jp
authors.forename: Kozo
authors.initials: K
authors.lastname: Shishido
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006801:Humans; D061065:Polyketides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D001688:Biological Products; D061065:Polyketides; D012717:Sesquiterpenes; D013729:Terpenes