title: Comparison of morphometric analysis based on T1- and T2-weighted MRI data for visualization of focal cortical dysplasia.
abstract: OBJECTIVE
  Focal cortical dysplasias (FCD) are highly epileptogenic lesions frequently accounting for pharmaco-resistant focal epilepsy. Visual MRI analysis combined with morphometric analysis of T1-weighted MRI data was shown to be of higher diagnostic sensitivity in detecting and delineating FCD than conventional visual analysis alone. Here we investigate whether morphometric analysis of T2-weighted MRI volume data sets is of equal benefit or perhaps more helpful for visualizing FCD.
  
  
  METHODS
  Morphometric analysis was applied to T1- and T2-weighted MRI volume data sets of 20 epilepsy patients with FCD using a fully automated MATLAB script with scanner- and sequence-specific normal databases for T1 and T2 images. For each modality, a new feature map (i.e., 'junction image') highlighting the FCD-typical blurring of the gray-white matter junction and quantifying this feature in comparison to the normal database in terms of z-scores was calculated. The resulting T1 and T2 'junction images' were compared for conspicuity and recognizability of the FCD both qualitatively by visual assessment and quantitatively by analysis of the mean z-scores inside and outside the lesions.
  
  
  RESULTS
  In 80% of the cases, the FCD presented with higher contrast and/or clearer delineation in the T2 than in the T1 'junction images' and were thus easier to recognize in these images. The quantitative analysis supported this impression: in 95% of cases, the ratio of mean z-scores inside and outside the FCD was higher in T2- than in T1-based 'junction images'. For the T2 'junction images', this ratio amounted to 8.7 on average and was thus more than twice as high as the corresponding T1 result of 3.7 (p<.003).
  
  
  CONCLUSIONS
  Concerning visualization of FCD by highlighting blurring of the gray-white matter junction, the results of the present study indicate that morphometric analysis of T2-weighted MRI data on average is superior to T1-based morphometry.
authors.affiliation: Hamburg Epilepsy Center, Protestant Hospital Alsterdorf, Bodelschwinghstr. 24, 22337 Hamburg, Germany. Electronic address: p.house@eka.alsterdorf.de.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: House
authors.forename: Michael
authors.initials: M
authors.lastname: Lanz
authors.forename: Brigitte
authors.initials: B
authors.lastname: Holst
authors.forename: Tobias
authors.initials: T
authors.lastname: Martens
authors.forename: Stefan
authors.initials: S
authors.lastname: Stodieck
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Huppertz
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D016208:Databases, Factual; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D054220:Malformations of Cortical Development / Q000473:pathology*; D008875:Middle Aged; D055815:Young Adult
keywords: Focal cortical dysplasia (FCD); Focal epilepsy; MRI; Morphometric analysis; Post-processing; T2