title: Clinical improvement of striae distensae in Korean patients using a combination of fractionated microneedle radiofrequency and fractional carbon dioxide laser.
abstract: BACKGROUND
  Striae distensae are dermal scars with flattening and atrophy of the epidermis.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of combination therapy with fractionated microneedle radiofrequency (RF) and fractional carbon dioxide (CO2) laser in the treatment of striae distensae.
  
  
  METHODS
  Thirty patients (30 female; mean age 33, range 21-51, Fitzpatrick skin type IV) with moderate to severe striae distensae were enrolled in this study. Patients were divided into three groups: fractional CO2 laser only (n = 10), microneedle RF only (n = 10), and combination (n = 10).
  
  
  RESULTS
  Improvement was evaluated using a visual analogue scale (range 1-4). Mean clinical improvement score of the dermatologist was 2.2 in the fractional CO2 laser-treated group, 1.8 in the microneedle RF-treated group, and 3.4 in the combination group. Through skin biopsy, we observed thickened epidermis and a clear increase in the number of collagen fibers in the microneedle RF- and fractional CO2 combination-treated sites. Consistent with these results, greater expression of transforming growth factor-β1 and stratifin was observed in treated sites.
  
  
  CONCLUSIONS
  Combination therapy of fractionated microneedle RF and fractional CO2 laser is a safe treatment protocol with a positive therapeutic effect on striae distensae.
authors.affiliation: Department of Dermatology, Keimyung University School of Medicine, Daegu, South Korea.
authors.forename: Han-Won
authors.initials: HW
authors.lastname: Ryu
authors.forename: Sung-Ae
authors.initials: SA
authors.lastname: Kim
authors.forename: Hye Ra
authors.initials: HR
authors.lastname: Jung
authors.forename: Young-Wook
authors.initials: YW
authors.lastname: Ryoo
authors.forename: Kyu-Suk
authors.initials: KS
authors.lastname: Lee
authors.forename: Jae-We
authors.initials: JW
authors.lastname: Cho
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002245:Carbon Dioxide; D017115:Catheter Ablation; D003131:Combined Modality Therapy; D005092:Exonucleases / Q000378:metabolism; D005095:Exoribonucleases; D005260:Female; D006801:Humans; D054020:Lasers, Gas / Q000627:therapeutic use*; D008875:Middle Aged; D056910:Republic of Korea; D057896:Striae Distensae / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; D053773:Transforming Growth Factor beta1; D002245:Carbon Dioxide; D005092:Exonucleases; D005095:Exoribonucleases; C413442:SFN protein, human