title: Metabolic syndrome and mean platelet volume variation in patients with chest pain and negative cardiac enzymes.
abstract: BACKGROUND
  The mean platelet volume (MPV) is an easily measurable parameter directly correlated with platelet aggregation function, proven to be increased in acute coronary syndromes, but also in the presence of cardiovascular risk factors such as the metabolic syndrome, dyslipidemia, diabetes mellitus, arterial hypertension.
  
  
  OBJECTIVE
  This study intended to assess the role of the metabolic syndrome in MPV variation in patients presenting with chest pain.
  
  
  METHODS
  We retrospectively analyzed data from 122 patients with chest pain and negative cardiac enzymes admitted consecutively to our clinic from September 1st 2011 to January 30th 2012. Our group included 27 (22.13%) patients with stable angina (SA), 74 (60.65%) patients with unstable angina (UA) and 21 (17.22%) patients with non-coronary chest pain.
  
  
  RESULTS
  Patients with UA had a higher mean value of the MPV 9.31 ± 1.19 fL compared to patients with SA 8.72 ± 1.14 fL (p=0.0279) and patients with non-coronary chest pain 8.85 ± 0.90 L (p=0.0908). All the patients with metabolic syndrome had increased MPVs, regardless of the etiology of chest pain. Patients with non-coronary chest pain presented significantly higher MPVs if associated with metabolic syndrome or arterial hypertension.
  
  
  CONCLUSIONS
  Patients with cardiovascular risk factors, especially complex ones like the metabolic syndrome had an increased MPV, as did the patients with UA whether or not associated with the risk factors. In patients without such comorbidities, the MPV could be useful in distinguishing unstable angina from non-coronary chest pain.
authors.affiliation: 1st Internal Medicine and Cardiology Department, Sfantul Pantelimon Clinical Emergency Hospital Bucharest, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Nechita
authors.forename: C
authors.initials: C
authors.lastname: Delcea
authors.forename: V
authors.initials: V
authors.lastname: Enache
authors.forename: R L
authors.initials: RL
authors.lastname: Ploesteanu
authors.forename: C
authors.initials: C
authors.lastname: Cazacu
authors.forename: A M
authors.initials: AM
authors.lastname: Andronescu
authors.forename: A M
authors.initials: AM
authors.lastname: Stroi
authors.forename: C S
authors.initials: CS
authors.lastname: Stamate
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000503:physiopathology; D002637:Chest Pain / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D012189:Retrospective Studies
keywords: MPV; mean platelet volume; metabolic syndrome; unstable angina
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