title: Chemical properties of a polysaccharide purified from solid-state fermentation of Auricularia auricular and its biological activity as a hypolipidemic agent.
abstract: A water-soluble crude polysaccharide was extracted by hot water from Auricularia auricular mycelium grown under solid-state fermentation (SSF). The crude polysaccharide was purified by DEAE Sephadex A-50 and Sephadex G-200 chromatography. Fourier transform infrared spectroscopy and nuclear magnetic resonance ((1) H NMR) spectroscopy were used to investigate the structure of the purified A. auricular polysaccharide (AAP-I) and revealed that it is α-glycosidically linked. After 14 and 28 days of AAP-I orally administered, the AAP-I significantly decreased the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in mice in which hyperlipidemia had been induced by a high fat diet (P < 0.05). The results revealed that AAP-I from SSF of A. auricular mycelium possesses potent hypolipidemic properties. The polysaccharide may be useful as a functional food additive and a hypolipidemic agent.
authors.affiliation: College of Food Science, Fujian Agriculture and Forestry Univ. Fuzhou, Fujian 350002, China; Natl. Engineering Research Center of Juncao, Fuzhou, Fujian 350002, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zeng
authors.forename: Chao
authors.initials: C
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Pang
authors.forename: Zhanxi
authors.initials: Z
authors.lastname: Lin
authors.forename: Yifan
authors.initials: Y
authors.lastname: Huang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001487:Basidiomycota / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D003911:Dextrans / Q000737:chemistry; D059305:Diet, High-Fat; D005285:Fermentation; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008970:Molecular Weight; D025282:Mycelium / Q000378:metabolism; D011134:Polysaccharides / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D014280:Triglycerides / Q000097:blood
chemical_list: D003911:Dextrans; D000960:Hypolipidemic Agents; D011134:Polysaccharides; D014280:Triglycerides; C025614:sephadex; D002784:Cholesterol
keywords: Auricularia auricula; chemical properties; hypolipidemic; polysaccharide; solid-state fermentation