title: Adverse drug reactions in veterinary patients associated with drug transporters.
abstract: For many drugs used in veterinary practice, plasma and tissue concentrations are highly dependent on the activity of drug transporters. This article describes how functional changes in drug transporters, whether mediated by genetic variability or drug-drug interactions, affect drug disposition and, ultimately, drug safety and efficacy in veterinary patients. A greater understanding of species, breed, and individual (genetic) differences in drug transporter function, as well as drug-drug interactions involving drug transporters, will result in improved strategies for drug design and will enable veterinarians to incorporate individualized medicine in their practices.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA. kmealey@vetmed.wsu.edu
authors.forename: Katrina L
authors.initials: KL
authors.lastname: Mealey
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism; D002415:Cats; D004283:Dog Diseases / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism; D004285:Dogs; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics*; D005786:Gene Expression Regulation; D027361:Organic Anion Transporters / Q000235:genetics / Q000378:metabolism*; D010597:Pharmacogenetics; D013045:Species Specificity
chemical_list: D018528:ATP-Binding Cassette Transporters; D027361:Organic Anion Transporters
keywords: ABCB1; ABCG2; ATP-binding cassette transporters; Pharmacogenetics; Solute carrier