title: Collaborative multicenter trials in Latin America: challenges and opportunities in orthopedic and trauma surgery.
abstract: CONTEXT AND OBJECTIVE Orthopedic research agendas should be considered from a worldwide perspective. Efforts should be planned as the means for obtaining evidence that is valid for health promotion with global outreach. DESIGN AND SETTING Exploratory study conducted at Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil, and McMaster University, Hamilton, Canada. METHODS We identified and analyzed collaborative and multicenter research in Latin America, taking into account American and Canadian efforts as the reference points. We explored aspects of the data available from official sources and used data from traffic accidents as a model for discussing collaborative research in these countries. RESULTS The evaluation showed that the proportion of collaborative and multicenter studies in our setting is small. A brief analysis showed that the death rate due to traffic accidents is very high. Thus, it seems clear to us that initiatives involving collaborative studies are important for defining and better understanding the patterns of injuries resulting from orthopedic trauma and the forms of treatment. Orthopedic research may be an important tool for bringing together orthopedic surgeons, researchers and medical societies for joint action. CONCLUSIONS We have indicated some practical guidelines for initiatives in collaborative research and have proposed some solutions with a summarized plan of action for conducting evidence-based research involving orthopedic trauma.
authors.affiliation: Department of Orthopedics and Traumatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil. vymoraes@gmail.com
authors.forename: Vinicius Ynoe de
authors.initials: VY
authors.lastname: Moraes
authors.forename: Joao Carlos
authors.initials: JC
authors.lastname: Belloti
authors.forename: Flavio
authors.initials: F
authors.lastname: Faloppa
authors.forename: Mohit
authors.initials: M
authors.lastname: Bhandari
mesh_terms: D000063:Accidents, Traffic / Q000706:statistics & numerical data; D002170:Canada / Q000453:epidemiology; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data* / Q000639:trends; D009985:Orthopedics; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D014194:Traumatology; D014481:United States / Q000453:epidemiology; D014947:Wounds and Injuries / Q000191:economics / Q000453:epidemiology
references.citation: Control Clin Trials. 1998 Aug;19(4):314-35
references.pmid: 9683309
references.citation: Inj Control Saf Promot. 2003 Mar-Jun;10(1-2):13-20
references.pmid: 12772481
references.citation: J Orthop Res. 2012 Oct;30(10):1523-8
references.pmid: 22508437
references.citation: J Bone Joint Surg Am. 2009 May;91 Suppl 3:80-6
references.pmid: 19411504
references.citation: Sao Paulo Med J. 2011 Mar;129(2):94-8
references.pmid: 21603786
references.citation: Rev Bras Ortop. 2015 Nov 16;45(6):601-5
references.pmid: 27026971
references.citation: Lancet. 2005 Aug 27-Sep 2;366(9487):703-4
references.pmid: 16130228
references.citation: Indian J Orthop. 2009 Apr;43(2):111-6
references.pmid: 19838358
references.citation: J Am Coll Cardiol. 2005 Feb 15;45(4):525-30
references.pmid: 15708698
references.citation: Patient Saf Surg. 2011 Sep 25;5:23
references.pmid: 21943304
references.citation: Injury. 2012 Jun;43(6):891-7
references.pmid: 22204774
references.citation: J Orthop Trauma. 2009 Jul;23(6):479-84
references.pmid: 19550238
references.citation: J Bone Joint Surg Am. 2005 Jan;87(1):214-7
references.pmid: 15634834
references.citation: Trop Med Int Health. 1997 May;2(5):445-60
references.pmid: 9217700
references.citation: J Bone Joint Surg Am. 2011 Mar 2;93(5):e15
references.pmid: 21368069
references.citation: Lancet. 2009 Apr 4;373(9670):1175-82
references.pmid: 19329177