title: Single nucleotide polymorphisms in cholesteryl ester transfer protein gene and recurrent coronary heart disease or mortality in patients with established atherosclerosis.
abstract: It is not known whether genetic variants in the cholesteryl ester transfer protein (CETP) gene are associated with recurrent coronary heart disease events or mortality in secondary prevention patients. Among 3,717 patients with acute coronary syndrome or coronary artery bypass grafting (CABG) enrolled in a prospective genetic registry, we evaluated whether CETP gene variants previously shown to be associated with reduced CETP activity and high-density lipoprotein cholesterol increase ("A" allele for both TaqIB [rs708272] and rs12149545) are associated with a reduction in recurrent myocardial infarction (MI), recurrent revascularization, or death. At 4.5 years of follow-up, 439 recurrent MI, 698 recurrent revascularizations, and 756 deaths occurred. Using an additive model of inheritance, the "A" allele for rs708272 was not associated with recurrent MI (hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.78 to 1.17 for AG; HR 0.89, 95% CI 0.67 to 1.19 for AA; compared with GG genotype), recurrent revascularization (HR 1.13, 95% CI 0.95 to 1.33 for AG; HR 1.05, 95% CI 0.84 to 1.32 for AA), or mortality (HR 1.02, 95% CI 0.86 to 1.19 for AG; HR 1.11, 95% CI 0.91 to 1.37 for AA) in the overall cohort. Similar results were seen for the "A" allele for rs12149545. In the CABG subgroup, AG genotype for rs708272 was associated with an increased mortality (HR 1.38, 95% CI 1.06 to 1.79) compared with GG genotype. Results remained consistent using dominant model of inheritance. In conclusion, genetic CETP variants were not associated with recurrent MI or recurrent revascularization in overall cohort with a possible mortality increase in patients who underwent CABG.
authors.affiliation: Health Services Research and Development Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas; Section of Cardiovascular Research, Department of Internal Medicine, Baylor College of Medicine, Houston, Texas. Electronic address: virani@bcm.edu.
authors.forename: Salim S
authors.initials: SS
authors.lastname: Virani
authors.forename: Vei-Vei
authors.initials: VV
authors.lastname: Lee
authors.forename: Ariel
authors.initials: A
authors.lastname: Brautbar
authors.forename: Megan L
authors.initials: ML
authors.lastname: Grove
authors.forename: Vijay
authors.initials: V
authors.lastname: Nambi
authors.forename: Mahboob
authors.initials: M
authors.lastname: Alam
authors.forename: MacArthur
authors.initials: M
authors.lastname: Elayda
authors.forename: James M
authors.initials: JM
authors.lastname: Wilson
authors.forename: James T
authors.initials: JT
authors.lastname: Willerson
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.forename: Christie M
authors.initials: CM
authors.lastname: Ballantyne
mesh_terms: D000369:Aged, 80 and over; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood / Q000235:genetics*; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D004247:DNA / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D004247:DNA
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