title: AMGET, an R-Based Postprocessing Tool for ADAPT 5.
abstract: ADAPT 5 is a powerful modeling software for population pharmacokinetic and pharmacodynamic systems analysis, but provides limited built-in functionality for creating pre- and post-analysis diagnostic plots. ADAPT 5 Model Evaluation Graphical Toolkit (AMGET), an external package written in the open source R programming language, was developed specifically to support efficient postprocessing of ADAPT 5 runs, as well as NONMEM and S-ADAPT runs. Using interactive navigational menus, users of AMGET are able to rapidly create informative diagnostic plots enriched by the display of numerical and graphical elements with a high degree of customization using a simple settings spreadsheet. This article describes each feature of the AMGET package and illustrates how it allows users to utilize the powerful numerical routines of the ADAPT 5 package in a more efficient manner through the use of a simulated dataset and a simple pharmacokinetic model optimized using the maximum likelihood expectation maximization (MLEM) algorithm of ADAPT 5.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e61; doi:10.1038/psp.2013.36; published online 31 July 2013.
authors.affiliation: Department of Pharmacy Practice, School of Pharmacy, University at Buffalo, SUNY, Buffalo, New York, USA.
authors.forename: B
authors.initials: B
authors.lastname: Guiastrennec
authors.forename: L
authors.initials: L
authors.lastname: Wollenberg
authors.forename: A
authors.initials: A
authors.lastname: Forrest
authors.forename: S
authors.initials: S
authors.lastname: Ait-Oudhia
references.citation: Comput Methods Programs Biomed. 1999 Jan;58(1):51-64
references.pmid: 10195646
references.citation: Comput Methods Programs Biomed. 2005 Jun;78(3):259-67
references.pmid: 15899310
references.citation: AAPS J. 2011 Jun;13(2):201-11
references.pmid: 21369876
references.citation: Comput Methods Programs Biomed. 2011 Dec;104(3):461-71
references.pmid: 21555161