title: Ventricular remodeling in growing rats with experimental diabetes: The impact of swimming training.
abstract: Diabetic cardiomyopathy is associated with cardiac muscle remodeling, resulting in myocardial dysfunction, whereas exercise training (ET) is a useful nonpharmacological strategy for the therapy of cardiac diseases. This study tested the effects of low-intensity swimming-training on the structural remodeling of the left ventricle (LV) in growing rats with unmanaged experimental diabetes. Thirty-day-old male Wistar rats were divided into four groups (n=5/group): sedentary-control (SC), exercised-control (EC), sedentary-diabetic (SD), and exercised-diabetic (ED). Swimming-training rats exercised 5 days/week, 90min/day, with a load of 5% BW during 8 weeks. Sections of LV were stained with Periodic acid-Schiff, Sirius Red, and Gomori's reticulin. Seven days and 8 weeks after streptozotocin (STZ) induction (60mgkg(-1) BW), blood glucose (BG) in the diabetic groups (SD=581.40±40.48; ED=558.00±48.89) was greater (p<0.05) than in their controls (SC=88.80±21.70; EC=85.60±11.55). Swimming-training reduced BG by 23mg/dL in the diabetics (p>0.05). The LV of diabetic rats had increased interstitial collagen and reticular fibers on the extracellular matrix and presented glycogen accumulation. More importantly, all these adverse tissue changes induced by STZ were attenuated by ET. Together, these findings support the idea of a beneficial role of exercise in the LV remodeling in rats with unmanaged type-1 diabetes mellitus.
authors.affiliation: Department of General Biology, Federal University of Viçosa, Viçosa, MG, Brazil; Department of Basic Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil.
authors.forename: Edson
authors.initials: E
authors.lastname: Silva
authors.forename: Antônio J
authors.initials: AJ
authors.lastname: Natali
authors.forename: Márcia F
authors.initials: MF
authors.lastname: Silva
authors.forename: Gilton J
authors.initials: GJ
authors.lastname: Gomes
authors.forename: Daise N Q
authors.initials: DN
authors.lastname: Cunha
authors.forename: Regiane M S
authors.initials: RM
authors.lastname: Ramos
authors.forename: Marileila M
authors.initials: MM
authors.lastname: Toledo
authors.forename: Filipe R
authors.initials: FR
authors.lastname: Drummond
authors.forename: Felipe G
authors.initials: FG
authors.lastname: Belfort
authors.forename: Rômulo D
authors.initials: RD
authors.lastname: Novaes
authors.forename: Izabel R S C
authors.initials: IR
authors.lastname: Maldonado
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D058065:Diabetic Cardiomyopathies / Q000473:pathology / Q000517:prevention & control*; D004562:Electrocardiography; D007150:Immunohistochemistry; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming; D020257:Ventricular Remodeling / Q000502:physiology*
keywords: Collagen matrix; Diabetes mellitus; Exercise; Fibrosis; Ventricular remodeling