title: Mean platelet volume in patients with carbon monoxide poisoning.
abstract: Carbon monoxide (CO) poisoning is frequent and can lead to high morbidity and mortality. Some studies have indicated increased platelet activation and aggregation in CO poisoning. Thus, we investigated mean platelet volume (MPV), an indicator of platelet activation, in patients with CO poisoning. We included 193 (117 women) patients who presented with a diagnosis of CO poisoning between June 2011 and March 2013. Control group was composed of 39 (15 women) patients. Troponin and creatine kinase MB levels were significantly higher in the CO poisoning group. Platelet counts were significantly higher in patients with CO poisoning (281 ± 76 vs 248 ± 65 × 10(9), respectively; P = .01). Similarly, MPV was significantly higher in the CO poisoning group (8.9 ± 0.8 vs 7.9 ± 0.9 fL, respectively; P < .001). Elevated MPV values may indicate that patients with CO poisoning have a higher risk of thromboembolic and cardiovascular complications due to platelet activation.
authors.affiliation: 1Department of Cardiology, Isparta State Hospital, Isparta, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karabacak
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
authors.forename: Kenan Ahmet
authors.initials: KA
authors.lastname: Türkdogan
authors.forename: Ali
authors.initials: A
authors.lastname: Duman
authors.forename: Orhan
authors.initials: O
authors.lastname: Akpinar
authors.forename: Pinar
authors.initials: P
authors.lastname: Karabacak
mesh_terms: D002249:Carbon Monoxide Poisoning / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D010979:Platelet Function Tests; D012737:Sex Factors
keywords: carbon monoxide; creatine kinase; mean platelet volume; platelet count; poisoning; troponin