title: Engineering Grp170-based immune modulators for cancer immunotherapy.
abstract: We have recently demonstrated that glucose-regulated protein 170 (Grp170), a stress-responsive molecular chaperone of the endoplasmic reticulum, can be exploited to stimulate anticancer immunity due to its superior antigen chaperoning and delivering capacity. The immune remodeling of the tumor microenvironment induced by a Grp170-based chaperone leads to immune responses that effectively control the progression of both primary neoplasms and their metastases. Our findings support the development of Grp170-based immunomodulating strategies to potentiate antitumor immune responses.
authors.affiliation: Department of Human and Molecular Genetics; Virginia Commonwealth University School of Medicine; Richmond, VA USA ; VCU Institute of Molecular Medicine; Virginia Commonwealth University School of Medicine; Richmond, VA USA ; VCU Massey Cancer Center; Virginia Commonwealth University School of Medicine; Richmond, VA USA.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Yu
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Wang
keywords: dendritic cells; glucose-regulated protein 170; immune modulator molecular chaperone; tumor microenvironment; vaccine
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