title: Lifetime and current mood and anxiety disorders in short-term and long-term abstinent alcoholics.
abstract: BACKGROUND
  A high prevalence of comorbid mood and anxiety disorders has been demonstrated in alcoholics. We examined lifetime and current mood and anxiety diagnoses and symptoms in long-term (mean 7.6 years; n = 110) and short-term (mean 10.1 weeks; n = 101) abstinent alcoholics (LTAA and STAA) and nonsubstance abusing controls (NSAC; n = 82). All alcoholics met DSM-IV lifetime alcohol dependence criteria. About half of each alcoholic group had lifetime drug dependence.
  
  
  METHODS
  Alcohol use was assessed using timeline follow-back methodology, and drug and alcohol use disorders were diagnosed using the AUDADIS-IV. Lifetime and current mood and anxiety disorder diagnoses and symptom counts were gathered using the computerized Diagnostic Interview Schedule.
  
  
  RESULTS
  Over 60% of STAA and LTAA had a lifetime internalizing diagnosis versus about 15% of NSAC, with no difference between STAA and LTAA. The group effect on lifetime diagnoses was independent of comorbid drug dependence or gender and was of comparable size for mood and anxiety disorders. Current diagnoses showed a similar pattern, except that STAA had more current mood diagnoses than LTAA. Excluding individuals with lifetime internalizing diagnoses, alcoholics still had more mood and anxiety symptoms than controls.
  
  
  CONCLUSIONS
  (i) The presence of a lifetime mood or anxiety diagnosis or of a current anxiety diagnosis did not differ between STAA and LTAA, suggesting that such diagnoses do not impact one's ability to achieve or maintain abstinence. (ii) Prevalence of mood and anxiety diagnoses was unaffected by presence of a comorbid substance use disorder, and (iii) excluding individuals with a mood or anxiety diagnosis does not eliminate mood and anxiety symptom count differences between groups.
authors.affiliation: Neurobehavioral Research, Inc. (GF), Honolulu, Hawaii; Department of Psychology (GF), University of Hawaii, Honolulu, Hawaii.
authors.forename: George
authors.initials: G
authors.lastname: Fein
mesh_terms: D000328:Adult; D064829:Alcohol Abstinence / Q000523:psychology* / Q000706:statistics & numerical data; D000437:Alcoholism / Q000150:complications / Q000453:epidemiology / Q000523:psychology*; D001008:Anxiety Disorders / Q000150:complications* / Q000453:epidemiology; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence
keywords: Abstinence; Alcohol; Anxiety Disorder; Mood Disorder
references.citation: Arch Gen Psychiatry. 1997 Apr;54(4):313-21
references.pmid: 9107147
references.citation: Addiction. 2005 Jun;100(6):787-96
references.pmid: 15918809
references.citation: Arch Gen Psychiatry. 2004 Aug;61(8):807-16
references.pmid: 15289279
references.citation: J Psychiatr Res. 1991;25(3):117-29
references.pmid: 1941708
references.citation: Can J Psychiatry. 1991 Dec;36(10):728-31
references.pmid: 1790517
references.citation: Acta Psychiatr Scand. 1995 Nov;92(5):378-85
references.pmid: 8619343
references.citation: Mol Psychiatry. 2009 Nov;14(11):1051-66
references.pmid: 18427559
references.citation: Addiction. 2005 Mar;100(3):405-13
references.pmid: 15733254
references.citation: Am J Psychiatry. 1983 Jun;140(6):711-4
references.pmid: 6846629
references.citation: J Abnorm Child Psychol. 1995 Oct;23(5):641-59
references.pmid: 8568085
references.citation: Arch Gen Psychiatry. 2002 Sep;59(9):794-800
references.pmid: 12215078
references.citation: Br J Psychiatry. 2012 Jun;200(6):476-84
references.pmid: 22322459
references.citation: Arch Gen Psychiatry. 1998 Mar;55(3):259-65
references.pmid: 9510220
references.citation: Addict Behav. 1998 Nov-Dec;23(6):893-907
references.pmid: 9801724
references.citation: J Psychiatr Res. 1992 Jan;26(1):85-95
references.pmid: 1560412
references.citation: Alcohol Clin Exp Res. 2006 May;30(5):851-9
references.pmid: 16634854
references.citation: Psychiatry Res. 1988 Mar;23(3):335-44
references.pmid: 3387505
references.citation: BMC Psychiatry. 2006 Oct 20;6:44
references.pmid: 17054775
references.citation: J Abnorm Psychol. 1982 Jun;91(3):199-209
references.pmid: 7096790
references.citation: J Stud Alcohol. 1988 May;49(3):219-24
references.pmid: 3374135
references.citation: Alcohol Clin Exp Res. 2007 May;31(5):795-803
references.pmid: 17378917
references.citation: JAMA. 1990 Nov 21;264(19):2511-8
references.pmid: 2232018
references.citation: Drug Alcohol Depend. 1985 May;15(1-2):61-7
references.pmid: 4017879
references.citation: J Stud Alcohol. 1982 Nov;43(11):1157-70
references.pmid: 7182675
references.citation: Arch Gen Psychiatry. 2004 Nov;61(11):1107-15
references.pmid: 15520358
references.citation: Arch Gen Psychiatry. 1987 Jun;44(6):505-13
references.pmid: 3579499
references.citation: Alcohol Clin Exp Res. 2013 Jan;37 Suppl 1:E271-80
references.pmid: 22834935
references.citation: Arch Gen Psychiatry. 2004 Apr;61(4):361-8
references.pmid: 15066894
references.citation: Arch Gen Psychiatry. 1985 Nov;42(11):1050-5
references.pmid: 4051682
references.citation: Arch Gen Psychiatry. 2007 Jul;64(7):830-42
references.pmid: 17606817
references.citation: Am J Psychiatry. 1990 Dec;147(12):1662-6
references.pmid: 2123079