title: Pregnancy Complications and Later Development of Hypertension.
abstract: Pregnancy complications such as preeclampsia and diabetes affect approximately 5 to 10 % of all pregnancies and compromise maternal and fetal health during gestation. Complications during pregnancy may also contribute to the development of hypertension and future cardiovascular risk in the mother. Moreover, fetal exposure to hypertension and diabetes during pregnancy can program hypertension and cardiovascular disease in the offspring. Transgenerational transmission of programmed cardiovascular risk highlights the importance of understanding the mechanisms that link complications during pregnancy with later hypertension in her offspring and subsequent generations. However, experimental studies are needed to investigate the cause and effect of increased blood pressure in the mother following a complicated pregnancy and provide insight into the development of preventative measures that may improve the long-term cardiovascular health of women and their offspring.
authors.affiliation: Department of Physiology and Biophysics and the Women's Health Research Center, University of Mississippi Medical Center, Jackson, MS, 39216.
authors.forename: Suttira
authors.initials: S
authors.lastname: Intapad
authors.forename: Barbara T
authors.initials: BT
authors.lastname: Alexander
keywords: Diabetes; Fetal programming; Hypertension; Preeclampsia; Pregnancy complications; Transgenerational
references.citation: Life Sci. 2012 Apr 20;90(15-16):571-7
references.pmid: 22365957
references.citation: Epigenomics. 2010 Aug;2(4):539-49
references.pmid: 22121973
references.citation: Am J Obstet Gynecol. 2013 Apr;208(4):301.e1-6
references.pmid: 23159698
references.citation: J Pharmacol Exp Ther. 2002 May;301(2):402-9
references.pmid: 11961037
references.citation: Circulation. 2010 Sep 21;122(12):1192-9
references.pmid: 20823385
references.citation: Hypertension. 2012 Jul;60(1):114-22
references.pmid: 22585945
references.citation: Obstet Gynecol. 2009 Nov;114(5):961-970
references.pmid: 20168095
references.citation: Acta Obstet Gynecol Scand. 2007;86(5):565-71
references.pmid: 17464585
references.citation: J Clin Hypertens (Greenwich). 2007 Jul;9(7):560-6
references.pmid: 17617769
references.citation: Hypertens Pregnancy. 2000;19(2):199-209
references.pmid: 10877988
references.citation: Circulation. 2010 Nov 2;122(18):1846-53
references.pmid: 20956209
references.citation: Sao Paulo Med J. 2010 Jan;128(1):10-3
references.pmid: 20512274
references.citation: Hypertension. 2007 Mar;49(3):612-7
references.pmid: 17210828
references.citation: Gend Med. 2008;5 Suppl A:S121-32
references.pmid: 18395678
references.citation: Am J Hypertens. 2002 Feb;15(2 Pt 1):170-5
references.pmid: 11863253
references.citation: Exp Cell Res. 2012 May 15;318(9):1049-56
references.pmid: 22410251
references.citation: Clin Sci (Lond). 2012 Jan;122(2):53-61
references.pmid: 21745185
references.citation: Clin Exp Hypertens. 2012;34(5):334-41
references.pmid: 22468840
references.citation: Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R80-4
references.pmid: 15458966
references.citation: J Womens Health (Larchmt). 2011 Feb;20(2):287-93
references.pmid: 21265636
references.citation: Pediatrics. 2012 Jun;129(6):e1552-61
references.pmid: 22614768
references.citation: Circulation. 2010 Aug 3;122(5):478-87
references.pmid: 20644016
references.citation: Am J Public Health. 2011 Dec;101(12):2317-24
references.pmid: 22021306
references.citation: Kidney Int. 2005 Nov;68(5):2180-8
references.pmid: 16221217
references.citation: Neurol Clin. 2012 Aug;30(3):781-9
references.pmid: 22840789
references.citation: Hypertension. 2012 Aug;60(2):437-43
references.pmid: 22733460
references.citation: Am J Physiol Renal Physiol. 2008 Jul;295(1):F29-34
references.pmid: 18400872
references.citation: Clin Endocrinol (Oxf). 2012 Dec;77(6):808-15
references.pmid: 22642564
references.citation: JAMA. 2002 May 15;287(19):2534-41
references.pmid: 12020334
references.citation: Curr Diab Rep. 2012 Feb;12(1):43-52
references.pmid: 22037824
references.citation: Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H466-74
references.pmid: 18567715
references.citation: Diabetes Care. 1998 Dec;21(12):2111-5
references.pmid: 9839102
references.citation: Minerva Ginecol. 2012 Aug;64(4):259-80
references.pmid: 22728572
references.citation: Circ Res. 2007 Mar 2;100(4):520-6
references.pmid: 17255528
references.citation: Am J Obstet Gynecol. 1989 Nov;161(5):1200-4
references.pmid: 2589440
references.citation: Arch Cardiovasc Dis. 2012 Feb;105(2):99-113
references.pmid: 22424328
references.citation: Microcirculation. 2011 May;18(4):256-62
references.pmid: 21418376
references.citation: J Hypertens. 2012 Jun;30(6):1203-10
references.pmid: 22473021
references.citation: Mediators Inflamm. 2010;2010:908649
references.pmid: 21253506
references.citation: Gynecol Endocrinol. 2003 Apr;17(2):133-6
references.pmid: 12737674
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R758-63
references.pmid: 16917022
references.citation: Nat Med. 2006 Jun;12(6):642-9
references.pmid: 16751767
references.citation: PLoS One. 2012;7(9):e45188
references.pmid: 23028837
references.citation: Hypertension. 2010 May;55(5):1239-45
references.pmid: 20308605
references.citation: Atherosclerosis. 2004 Aug;175(2):189-202
references.pmid: 15262174
references.citation: PLoS One. 2012;7(8):e43637
references.pmid: 22952728
references.citation: J Clin Invest. 1999 Apr;103(7):945-52
references.pmid: 10194466
references.citation: Circulation. 2012 Mar 20;125(11):1367-80
references.pmid: 22344039
references.citation: J Clin Endocrinol Metab. 2005 Jul;90(7):3983-8
references.pmid: 15840749
references.citation: Circulation. 2010 Aug 10;122(6):579-84
references.pmid: 20660802
references.citation: Am Heart J. 2008 Nov;156(5):918-30
references.pmid: 19061708
references.citation: Exp Diabetes Res. 2011;2011:906154
references.pmid: 21804818
references.citation: J Matern Fetal Neonatal Med. 2010 Aug;23(8):880-6
references.pmid: 20441409
references.citation: Public Health. 2012 Jul;126(7):561-5
references.pmid: 22607982
references.citation: J Hypertens. 2012 Feb;30(2):351-8
references.pmid: 22179081
references.citation: Horm Behav. 2011 Mar;59(3):279-89
references.pmid: 20591431
references.citation: Hypertension. 2005 Apr;45(4):754-8
references.pmid: 15699462
references.citation: Vasa. 2012 Mar;41(2):96-104
references.pmid: 22403127
references.citation: Diabetes Care. 1996 Dec;19(12):1351-6
references.pmid: 8941463
references.citation: Br J Nutr. 2008 Oct;100(4):760-6
references.pmid: 18304387
references.citation: Adv Chronic Kidney Dis. 2008 Apr;15(2):101-6
references.pmid: 18334233
references.citation: Biomark Med. 2010 Jun;4(3):351-60
references.pmid: 20550469
references.citation: CMAJ. 2012 Nov 6;184(16):1777-84
references.pmid: 23008489
references.citation: Environ Health Perspect. 2006 Mar;114(3):A160-7
references.pmid: 16507447
references.citation: Hypertension. 2012 Jul;60(1):206-13
references.pmid: 22585946
references.citation: Am J Obstet Gynecol. 2003 Aug;189(2):494-500
references.pmid: 14520224
references.citation: Eur J Prev Cardiol. 2012 Oct;19(5):1138-44
references.pmid: 21859777
references.citation: Hypertension. 2003 Jul;42(1):39-42
references.pmid: 12743016
references.citation: Hypertension. 2008 Apr;51(4):970-5
references.pmid: 18259009
references.citation: Br J Nutr. 2007 Mar;97(3):435-9
references.pmid: 17313703
references.citation: Curr Opin Nephrol Hypertens. 2002 Mar;11(2):197-200
references.pmid: 11856913
references.citation: Hypertension. 2010 Jul;56(1):166-71
references.pmid: 20516394
references.citation: Placenta. 2010 Mar;31 Suppl:S40-6
references.pmid: 20116093
references.citation: Hypertension. 2011 Jul;58(1):57-62
references.pmid: 21606389
references.citation: J Hypertens. 2010 Oct;28(10):2046-52
references.pmid: 20616754
references.citation: Curr Hypertens Rep. 2007 Dec;9(6):480-5
references.pmid: 18367011
references.citation: Diabetes Care. 2006 Jan;29 Suppl 1:S43-8
references.pmid: 16373932
references.citation: Clin Sci (Lond). 2008 Jan;114(1):1-17
references.pmid: 18047465
references.citation: Reprod Sci. 2012 Dec;19(12):1332-42
references.pmid: 22902744
references.citation: Hypertension. 2011 Jul;58(1):63-9
references.pmid: 21606387
references.citation: Curr Hypertens Rep. 2011 Aug;13(4):269-75
references.pmid: 21465139
references.citation: J Physiol. 2008 Oct 1;586(19):4709-20
references.pmid: 18669533
references.citation: Lancet. 2005 Feb 26-Mar 4;365(9461):785-99
references.pmid: 15733721
references.citation: Hypertension. 2012 Feb;59(2):226-34
references.pmid: 22158643
references.citation: Hypertension. 2008 Jul;52(1):44-50
references.pmid: 18474830
references.citation: Diabetologia. 2012 Nov;55(11):3114-27
references.pmid: 22948491
references.citation: Epidemiology. 1999 Mar;10(2):153-60
references.pmid: 10069251
references.citation: DNA Cell Biol. 2011 Feb;30(2):79-84
references.pmid: 21043832
references.citation: J Hypertens. 2007 Nov;25(11):2301-7
references.pmid: 17921826
references.citation: Diabetologia. 2011 Mar;54(3):504-7
references.pmid: 21153896