title: The potential role of small heat shock proteins in mitochondria.
abstract: Mitochondria play a central role in cellular metabolism, calcium homeostasis, redox signaling and cell fates. Mitochondrial homeostasis is tightly regulated, and mitochondrial dysfunction is frequently associated with severe human pathologies. Small heat shock proteins are molecular chaperones that play major roles in development, stress responses, and diseases, and have been envisioned as targets for therapy. The mechanisms that lie behind the cytoprotection of small heat shock proteins are related to the regulation of mitochondrial functions. This review recapitulates the current knowledge of the expression of various small heat shock proteins in mitochondria and discusses their implication in the role of mitochondria and their regulation. Based on their involvement in mitochondrial normal physiology and pathology, a better understanding of their roles and regulation will pave the way for innovative approaches for the successful treatment of a range of stress-related syndromes whose etiology is based upon dysfunction of mitochondria.
authors.affiliation: Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
authors.forename: Liuwang
authors.initials: L
authors.lastname: Zeng
authors.forename: Jieqiong
authors.initials: J
authors.lastname: Tan
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Tonglin
authors.initials: T
authors.lastname: Lu
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Hu
mesh_terms: D000818:Animals; D017209:Apoptosis; D003459:Crystallins / Q000235:genetics / Q000378:metabolism*; D019610:Cytoprotection / Q000235:genetics; D005786:Gene Expression Regulation; D050888:Heat-Shock Proteins, Small / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018979:Myositis, Inclusion Body / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D003459:Crystallins; D050888:Heat-Shock Proteins, Small
keywords: Apoptosis; Cardioprotection; Cytoprotection; Mitochondria; Small heat shock proteins (sHsps)