title: Pantothenate kinase-associated neurodegeneration causing paradoxical vocal fold motion.
abstract: We report a patient with paradoxical vocal fold motion (PVFM) due to pantothenate kinase-associated neurodegeneration, a rare neurodegenerative disease and a subclass of neurodegeneration with brain iron accumulation disorders. PVFM is marked by normal vocal fold anatomy and physiology with intermittent adduction during the respiratory cycle. Many etiologies have been reported and include laryngeal hypersensitivity such as asthma and gastroesophageal reflux, functional disorders, and neurologic disorders such as focal respiratory dystonia. This case highlights the occasional association of PVFM with underlying neurologic disorders, especially those that disrupt autonomic functioning.
authors.affiliation: Department of Head and Neck Surgery, University of California, Los Angeles, CA, USA.
authors.forename: Sassan
authors.initials: S
authors.lastname: Rafizadeh
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Long
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000201:enzymology / Q000235:genetics; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D064706:Vocal Cord Dysfunction / Q000201:enzymology / Q000209:etiology*
chemical_list: D017853:Phosphotransferases (Alcohol Group Acceptor); C023088:pantothenate kinase
keywords: Neurodegeneration with brain iron accumulation; Pantothenate kinase-associated neurodegeneration; Paradoxical vocal fold motion