title: Relationships between absorption efficiency of elements in mammals and chemical properties.
abstract: Oral absorption efficiency is an important factor to consider in human risk assessment and varies widely between elements. Linking absorption efficiency to chemical properties facilitates the understanding of underlying processes and enables extrapolation across elements. In our study, oral absorption efficiency in humans was predicted for a number of elements based on their ionization energy and electronegativity. Data on oral absorption efficiency in humans were retrieved via a literature survey. A model was developed based on the assumption that ionic species readily react with biotic ligands. Accordingly, ionization energy was presumed to represent the reactivity and absorption of atoms in the gastrointestinal tract. The coefficients of the model were parameterized by fitting the quantitative relationship between absorption efficiency and ionization energy to data collected from well-standardized studies. Generally, absorption efficiency was strongly related to ionization energy, explaining 94% of the variability in absorption efficiency between elements reported by the International Commission on Radiological Protection (ICRP). In addition, the absorption efficiencies predicted based on ionization energy were within a factor of two of those given by the ICRP (ME = -0.05; RMSE = 0.31). However, the model is not applicable to alkaline metals and molybdenum because of the uniquely high solubility of their compounds or the flexible electron configuration of these elements. Approximately 56% of the variability in absorption efficiency between elements could be explained by electronegativity. These strong relationships between absorption efficiency and ionization energy and, to a lesser extent, electronegativity indicate potential for extrapolation across elements using atomic properties.
authors.affiliation: Department of Environmental Science, Institute for Water and Wetland Research, Faculty of Science, Radboud University Nijmegen , The Netherlands.
authors.forename: T T Yen
authors.initials: TT
authors.lastname: Le
authors.forename: A Jan
authors.initials: AJ
authors.lastname: Hendriks
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D006801:Humans; D007408:Intestinal Absorption; D008322:Mammals; D008962:Models, Theoretical; D013329:Structure-Activity Relationship