title: [Results and lessons of an innovating chemotherapy-induced nauseas and vomiting management strategy].
abstract: Current chemotherapy-induced nausea and vomiting management guidelines recommend taking into account the emetogenic potential of the chemotherapy employed as well as individual risk factors to such effects. We performed an interventional prospective study to assess the impact of an innovating therapeutic optimization strategy. The latter combines current guidelines application to a specific consultation in order to individualize the treatment. This study included 170 patients and covered a total of 1,746 days of various chemotherapies. Among these patients, 86.5% never vomited and 53.8% never had any nausea or vomiting. These results seem generally better than the ones found in the literature with all kinds of chemotherapies. Regarding them, we have attempted to highlight the determining criteria for a successful antiemetic treatment.
authors.affiliation: Hôpital d'instruction des armées Percy, service de pharmacie, 101, avenue Henri-Barbusse, 92141 Clamart, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Jandard
authors.forename: Morgane
authors.initials: M
authors.lastname: Guillaudin
authors.forename: Sacha
authors.initials: S
authors.lastname: Bédrossian
authors.forename: David
authors.initials: D
authors.lastname: Breton
authors.forename: Gisèle
authors.initials: G
authors.lastname: Camus
authors.forename: Michel
authors.initials: M
authors.lastname: Paillet
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rivière
authors.forename: Hervé
authors.initials: H
authors.lastname: Le Floch
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Reignier
authors.forename: Hervé
authors.initials: H
authors.lastname: Rimlinger
authors.forename: Marc
authors.initials: M
authors.lastname: Hervouet
authors.forename: Fabien
authors.initials: F
authors.lastname: Vaylet
authors.forename: Jacques
authors.initials: J
authors.lastname: Margery
authors.forename: Xavier
authors.initials: X
authors.lastname: Bohand
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001007:Anxiety / Q000175:diagnosis; D002985:Clinical Protocols; D004334:Drug Administration Schedule; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D057285:Precision Medicine / Q000379:methods; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents
keywords: antiemetic prophylaxis; chemotherapy; emesis; individualized therapy; nausea; supportive care