title: Distribution of CC-chemokine receptor-5-∆32 allele among the tribal and caste population of Vidarbha region of Maharashtra state.
abstract: BACKGROUND
  Genetic relationships among the ethnic groups are not uniform across the geographical region. Considering this assumption, we analyzed the frequency of the CC-chemokine receptor-5 (CCR5)-∆32 allele of the CCR5 chemokine receptor, which is considered a Caucasian marker, in Bhil tribal and Brahmin caste sample sets from the population.
  
  
  METHODS
  108 blood samples were collected from 6 tribe's populations and a caste population from the district of Vidarbha region.
  
  
  CONCLUSIONS
  The presence of low frequencies of CCR5-Δ32 in an individual of Bhil tribe (0.034, χ(2) value 0.017) in the present study implies that these communities may have a better resistance toward human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) than the other studied tribe sample, as non-show such mutation.
  
  
  CONCLUSIONS
  The marginal presence of the allele seen in the studied tribal population could be due to gene flow from the people of European descent. However, lack of the homozygous CCR5-Δ32 mutation and the low prevalence of heterozygous CCR5-Δ32 mutations suggest that the Indians are highly susceptible to HIV/AIDS, and this correlates with the highest number of HIV/AIDS infected individuals in India.
authors.affiliation: Department of Zoology, Shri Shivaji Science College, Amravati, India ; Department of Zoology, Institute of Science, Nagpur, India.
authors.forename: Arvind B
authors.initials: AB
authors.lastname: Chavhan
authors.forename: Santosh S
authors.initials: SS
authors.lastname: Pawar
authors.forename: Rajusing G
authors.initials: RG
authors.lastname: Jadhao
authors.forename: Kishor G
authors.initials: KG
authors.lastname: Patil
keywords: Allele frequency; CC-chemokine receptor-5-∆32; India; Vidarbha; genetic polymorphism; tribes
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