title: Lanostane triterpenoids with cytotoxic activities from the fruiting bodies of Ganoderma hainanense.
abstract: Twelve lanostane triterpenoids (1-12) including a new one 16α,26-dihydroxylanosta-8,24-dien-3-one (1) were isolated from the fruiting bodies of Ganoderma hainanense. The structure of the new compound was elucidated by 1D and 2D NMR and MS spectroscopic analyses. All isolates were evaluated for their cytotoxicities against human tumor cell lines K-562, SMMC-7721, and SGC-7901 and five compounds (1, 2, 5,7, and 9) showed definite cytotoxicities against K-562 cell line. Meanwhile, compounds 2, 5,7, and 9 exhibited cytotoxic activities against SMMC-7721 and SGC-7901 cell lines.
authors.affiliation: a Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou , 571101 , China.
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Ma
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.forename: Sheng-Zhuo
authors.initials: SZ
authors.lastname: Huang
authors.forename: Zhi-Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D032902:Ganoderma / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C586930:16alpha,26-dihydroxylanosta-8,24-dien-3-one; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes