title: Reduction in Framingham risk of cardiovascular disease in obese patients undergoing laparoscopic adjustable gastric banding.
abstract: BACKGROUND
  Obesity is a major risk factor for cardiovascular disease (CVD), with weight loss offering improvement in CVD risk factors.
  
  
  OBJECTIVE
  To examine whether weight loss in laparoscopic adjustable gastric band (LAGB)-treated obese patients is associated with meaningful reductions in estimated 10- and 30- year Framingham CVD risk 12-15 months post-LAGB.
  
  
  METHODS
  Obese adult patients [body mass index (BMI) ≥30 kg/m²] treated with LAGB were identified in a large US healthcare database. Patients without CVD at baseline and with measures of BMI, systolic blood pressure, diabetes, and smoking status at baseline and follow-up were eligible. Non-LAGB patients were propensity score matched to LAGB patients on baseline BMI, age, and gender. Estimated 10- and 30-year risk of developing CVD using office-based data, including BMI, was calculated at baseline and 12-15 months follow-up.
  
  
  RESULTS
  Mean BMI in LAGB patients (n = 647, average age 45.66 years, 81.1% female) decreased from 42.7 to 33.4 kg/m² (P < 0.0001), with 35.4% no longer obese; 10- and 30-year estimated CVD risk decreased from 10.8 to 7.6% (P < 0.0001) and 44.34 to 32.30% (P < 0.0001), respectively, 12-15 months post-LAGB. Improvements were significantly greater than in non-LAGB patients (N = 4,295) (P < 0.0001). In the subset with lipid data (n = 74), improvements in total (-20.6 mg/dL; P < 0.05) and high-density lipoprotein (+10.6 mg/dL, P < 0.0001) cholesterol 1 year post-LAGB were also observed.
  
  
  CONCLUSIONS
  Data from a US healthcare database show that individuals undergoing LAGB have significant weight loss and reductions in estimated 10- to 30-year CVD risk within 1 year post-LAGB.
authors.affiliation: Global Safety and Epidemiology, Allergan, Inc., 2525 Dupont Drive, MS AND-150, Irvine, CA 92612, USA. largent_joan@allergan.com
authors.forename: Joan A
authors.initials: JA
authors.lastname: Largent
authors.forename: Joseph
authors.initials: J
authors.lastname: Vasey
authors.forename: Leona
authors.initials: L
authors.lastname: Bessonova
authors.forename: Ted
authors.initials: T
authors.lastname: Okerson
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Wong
mesh_terms: D000328:Adult; D000368:Aged; D050110:Bariatric Surgery; D002318:Cardiovascular Diseases / Q000150:complications; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000601:surgery*; D012306:Risk; D016896:Treatment Outcome
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