title: [Correlation study of auto-immune antibodies and rheumatoid arthritis patients of Shen deficiency syndrome].
abstract: OBJECTIVE
  To investigate the correlation between auto-immune antibodies and rheumatoid arthritis (RA) patients of Shen deficiency syndrome (SDS), thus providing clinical evidence for further researches on molecular biological mechanisms of RA patients of SDS.
  
  
  METHODS
  Totally 451 RA patients were assigned to the SDS group and the non-SDS group. Their general conditions (including gender, age, duration, and age of onset), C reactive protein (CRP), erythrocyte sedimentation rate (ESR), platelet (PLT), disease activities (DAS28), auto-antibodies [rheumatoid factor (RF), anti-CCP antibodies, anti-nuclear antibody (ANA)] were compared between the two groups.
  
  
  RESULTS
  (1) The scores for EST, PLT, and DAS28 were obviously higher in the SDS group than in the non-SDS group (P < 0.05, P <0. 01). (2) The level of average RF was (697.32 +/-1 061.38 IU/mL) in the SDS group, higher than that in the non-SDS group (439.91 +/- 672.24 IU/mL, P <0.01). There was no statistical difference in anti-CCP antibody between the two groups (P >0.05).(3) The ANA positive rate of RA patients was 29. 63% (120/405). It was 37.19% (74/199) in RA patients of SDS and 22. 33% (46/206) in RA patients of non-SDS, showing statistical difference between the two groups (P <0.01). (4) The odds ratio for high level RF positive and ANA positive was 1. 574 and 2. 059 folds in RA patients of SDS as high as that in RA patients of non-SDS.
  
  
  CONCLUSIONS
  RA patients of SDS would have higher risk of having auto-immune antibodies, fastened development, more worsen joint damage, and more poor prognosis. Its mechanisms might be closely associated with autoimmune tolerance.
authors.affiliation: Department of Rheumatology, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China.
authors.forename: Lin-Kai
authors.initials: LK
authors.lastname: Guo
authors.forename: Shi-Zhi
authors.initials: SZ
authors.lastname: Luo
authors.forename: Qian-Hua
authors.initials: QH
authors.lastname: Liao
authors.forename: Ruo-Gu
authors.initials: RG
authors.lastname: Lai
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Liu
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Liu
authors.forename: Guang-xing
authors.initials: GX
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis*; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D055815:Young Adult
chemical_list: D001323:Autoantibodies