title: Importance of adrenergic pathways in women's cancers.
abstract: The importance of adrenergic pathways in cancer has long been suspected, but now there is mounting epidemiological, preclinical, and clinical evidence of its importance in gynecologic cancers. To date, most of these effects are mediated primarily through the beta 2 adrenergic receptor activation of the tumor cell cyclic AMP-protein kinase A signaling pathway. This review will discuss the current knowledge about the neuroendocrine stress response in gynecologic tumor biology.
authors.affiliation: Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, St. Louis, MO 63110, USA. thakerp@wudosis.wustl.edu
authors.forename: Premal H
authors.initials: PH
authors.lastname: Thaker
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sood
authors.forename: Lois M
authors.initials: LM
authors.lastname: Ramondetta
mesh_terms: D000818:Animals; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D011941:Receptors, Adrenergic / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011941:Receptors, Adrenergic
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