title: Sarcoidosis patient: an unexpected reaction to carbonic anhydrase enzyme inhibitor.
abstract: Ocular diseases are very common in many of the systemic diseases such as sarcoidosis, and may sometimes be the presenting symptom of the disease. In this case report, we present an unusual reaction of the sarcoid granuloma to carbonic anhydrase enzyme inhibitors (CAIs), which was encountered in a patient with ocular sarcoidosis. This observation was taken after a 2-week interval between a CT scan orbits and an MRI orbits which showed a decrease in size from 4×3×4 cm to 2.5×2.5×2 cm, respectively. We suspected the dorzolamide CAI to have had a significant role in the reduction in size. It is suggested that acidotic changes that occur due to the effect of the carbonic anhydrase inhibitor causes electrolyte imbalance, intracellular as well as extracellular, which lead to the reduction in the size of the granuloma.
authors.affiliation: Faculty of Medicine, Ophthalmology, Ain Shams University, Cairo, Egypt. yahya_khedr@hotmail.com
authors.forename: Yahya A H
authors.initials: YA
authors.lastname: Khedr
authors.forename: Abdulla H
authors.initials: AH
authors.lastname: Khedr
mesh_terms: D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use*; D005128:Eye Diseases / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012507:Sarcoidosis / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide
references.citation: Br J Ophthalmol. 2000 Jan;84(1):110-6
references.pmid: 10611110
references.citation: AJNR Am J Neuroradiol. 1998 Feb;19(2):336-7
references.pmid: 9504490