title: Septo-hippocampal GABAergic signaling across multiple modalities in awake mice.
abstract: Hippocampal interneurons receive GABAergic input from the medial septum. Using two-photon Ca(2+) imaging of axonal boutons in hippocampal CA1 of behaving mice, we found that populations of septo-hippocampal GABAergic boutons were activated during locomotion and salient sensory events; sensory responses scaled with stimulus intensity and were abolished by anesthesia. We found similar activity patterns among boutons with common putative postsynaptic targets, with low-dimensional bouton population dynamics being driven primarily by presynaptic spiking.
authors.affiliation: Department of Neuroscience, Columbia University, New York, New York, USA. pwk2108@columbia.edu
authors.forename: Patrick
authors.initials: P
authors.lastname: Kaifosh
authors.forename: Matthew
authors.initials: M
authors.lastname: Lovett-Barron
authors.forename: Gergely F
authors.initials: GF
authors.lastname: Turi
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Reardon
authors.forename: Attila
authors.initials: A
authors.lastname: Losonczy
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D002147:Calmodulin / Q000235:genetics / Q000378:metabolism; D000075402:Channelrhodopsins; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003213:Conditioning, Psychological; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology*; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism; D037121:Plant Lectins / Q000378:metabolism; D011506:Proteins / Q000235:genetics; D022661:RNA, Untranslated; D020665:Septum of Brain / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014851:Wakefulness / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D000779:Anesthetics, Local; D002147:Calmodulin; D000075402:Channelrhodopsins; D004268:DNA-Binding Proteins; C499942:Grhl3 protein, mouse; C110853:Gt(ROSA)26Sor non-coding RNA, mouse; D010320:Parvalbumins; D037121:Plant Lectins; D011506:Proteins; D022661:RNA, Untranslated; D014157:Transcription Factors; C034981:tomato lectin; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2
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