title: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome secondary to antituberculosis drugs and associated with human herpes virus-7 (HHV-7).
abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious reaction to drugs with a clinical presentation of rash, fever, lymph node enlargement and internal organ involvement. Reports have described the reactivation of human herpes virus 6 (HHV-6) and other HHVs in association with this syndrome. We report a 41-year-old woman who developed a rash, fever, liver dysfunction, eosinophilia and atypical monocytosis 21 days after initiation of the quadruple therapy for tuberculous cervical lymphadnitis. HHV-7 DNA was detected in blood by PCR suggesting infection with or more likely reactivation of HHV-7 as a contributing factor or consequence of this serious adverse drug reaction.
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK. nehal.draz@nhs.net
authors.forename: Nehal
authors.initials: N
authors.lastname: Draz
authors.forename: Sumona
authors.initials: S
authors.lastname: Datta
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Webster
authors.forename: Ian
authors.initials: I
authors.lastname: Cropley
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D005260:Female; D016199:Herpesvirus 7, Human; D006801:Humans; D019349:Roseolovirus Infections / Q000150:complications*
chemical_list: D000995:Antitubercular Agents
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