title: Skin toxicity of targeted cancer agents: mechanisms and intervention.
abstract: In recent years, targeted agents have rapidly evolved as effective tools in the clinical management of a broad range of malignant diseases. These agents disrupt molecular mechanisms and signaling modules that drive the malignant phenotype in defined subsets of malignancies. Beyond the intended cellular targets crucial to tumor growth and progression, these agents also affect signal transduction in normal cells and tissues. The resulting adverse events and their clinical management continue to change, as newer agents with an ever-increasing target spectrum are developed. We provide a succinct overview of dermatologic toxicities arising from the targeting of receptor tyrosine kinases and downstream effectors. Emergent insights into the pathomechanisms involved and the use of this knowledge base to alleviate cutaneous adverse events are discussed.
authors.affiliation: Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Rockefeller Outpatient Pavilion Suite 248, 160 East 53rd Street, New York, NY 10022, USA.
authors.forename: Viswanath Reddy
authors.initials: VR
authors.lastname: Belum
authors.forename: Hiral
authors.initials: H
authors.lastname: Fontanilla Patel
authors.forename: Mario E
authors.initials: ME
authors.lastname: Lacouture
authors.forename: Ulrich
authors.initials: U
authors.lastname: Rodeck
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D020794:Receptor Protein-Tyrosine Kinases / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D012868:Skin Abnormalities / Q000139:chemically induced / Q000145:classification / Q000378:metabolism* / Q000473:pathology*
chemical_list: D047428:Protein Kinase Inhibitors; D020794:Receptor Protein-Tyrosine Kinases