title: Haemoglobin, neutrophil to lymphocyte ratio and platelet count improve prognosis prediction of the TNM staging system in nasopharyngeal carcinoma: development and validation in 3,237 patients from a single institution.
abstract: OBJECTIVE
  To improve prediction efficiency by incorporating complete blood count (CBC) into the TNM system on 5 year disease-specific survival (DSS) for patients with nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  The CBC of 3237 patients undergoing radiotherapy was retrospectively evaluated. In total, 2820 patients treated with non-intensity-modulated radiotherapy (IMRT) were randomly divided into development (1895 patients) and validation cohorts (925 patients). The association of potential risk factors with 5 year DSS was tested by Cox proportional hazards analysis and a prognostic index was created by assigning weighted scores proportional to a regression coefficient to each factor. Each cohort was divided into low, intermediate and high prognostic index. The prognostic index was validated in the validation cohort and compared with the TNM system on prediction of 5 year DSS. Validation was repeated in another independent group of 417 patients treated with IMRT.
  
  
  RESULTS
  Eight independent prognostic factors were identified: gender, age, T or N stages, anaemia or thrombocytosis during radiotherapy, continuous reduction in haemoglobin, high neutrophil-lymphocyte ratio before radiotherapy. Each was assigned a number of points. The area under curve (AUC) of the prognostic index was larger than that of Union Internationale Contre le Cancer/American Joint Cancer Committee TNM system 2009 (0.697 versus 0.619, P < 0.001).
  
  
  CONCLUSIONS
  A CBC-based prognostic index was developed and had a higher prediction efficiency on 5 year DSS in NPC than the TNM system alone.
authors.affiliation: Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou Guangdong, China; State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Chang
authors.forename: J
authors.initials: J
authors.lastname: Gao
authors.forename: B Q
authors.initials: BQ
authors.lastname: Xu
authors.forename: S P
authors.initials: SP
authors.lastname: Guo
authors.forename: R B
authors.initials: RB
authors.lastname: Lu
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.forename: S M
authors.initials: SM
authors.lastname: Huang
authors.forename: F
authors.initials: F
authors.lastname: Han
authors.forename: Z G
authors.initials: ZG
authors.lastname: Liu
authors.forename: Y L
authors.initials: YL
authors.lastname: Tao
authors.forename: Z W
authors.initials: ZW
authors.lastname: Tu
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: X H
authors.initials: XH
authors.lastname: Li
authors.forename: Y F
authors.initials: YF
authors.lastname: Xia
mesh_terms: D001792:Blood Platelets / Q000473:pathology*; D002277:Carcinoma; D015331:Cohort Studies; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000097:blood* / Q000473:pathology / Q000532:radiotherapy; D009367:Neoplasm Staging; D009504:Neutrophils / Q000473:pathology*; D010976:Platelet Count; D011379:Prognosis; D016016:Proportional Hazards Models; D011897:Random Allocation; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D006454:Hemoglobins
keywords: Complete blood count; development; disease-specific survival; nasopharyngeal carcinoma; prognostic index; validation