title: Epidemiology of bacteremia in young hospitalized infants in Vientiane, Laos, 2000-2011.
abstract: As data about the causes of neonatal sepsis in low-income countries are inadequate, we reviewed the etiology and antibiotic susceptibilities of bacteremia in young infants in Laos. As Staphylococcus aureus is the leading cause of bacteremia in Lao infants, we also examined risk factors for this infection, in particular the local practice of warming mothers during the first weeks postpartum with hot coals under their beds (hot beds). Clinical and laboratory data regarding infants aged 0-60 days evaluated for sepsis within 72 h of admission to Mahosot Hospital in Vientiane, Laos, were reviewed, and 85 of 1438 (5.9%) infants' blood cultures grew a clinically significant organism. Most common were S. aureus, Escherichia coli and Klebsiella pneumoniae. Whereas no methicillin-resistant S. aureus was found, only 18% of E. coli isolates were susceptible to ampicillin. A history of sleeping on a hot bed with mother was associated with S. aureus bacteremia (odds ratio 4.8; 95% confidence interval 1.2-19.0).
authors.affiliation: Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.
authors.forename: Margot
authors.initials: M
authors.lastname: Anderson
authors.forename: Khonesavanh
authors.initials: K
authors.lastname: Luangxay
authors.forename: Kongkham
authors.initials: K
authors.lastname: Sisouk
authors.forename: Latdavan
authors.initials: L
authors.lastname: Vorlasan
authors.forename: Bandith
authors.initials: B
authors.lastname: Soumphonphakdy
authors.forename: Vanmaly
authors.initials: V
authors.lastname: Sengmouang
authors.forename: Vilada
authors.initials: V
authors.lastname: Chansamouth
authors.forename: Koukeo
authors.initials: K
authors.lastname: Phommasone
authors.forename: Russell
authors.initials: R
authors.lastname: Van Dyke
authors.forename: Euming
authors.initials: E
authors.lastname: Chong
authors.forename: David A B
authors.initials: DA
authors.lastname: Dance
authors.forename: Rattanaphone
authors.initials: R
authors.lastname: Phetsouvanh
authors.forename: Paul N
authors.initials: PN
authors.lastname: Newton
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007710:Klebsiella Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000302:isolation & purification; D007812:Laos / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D012307:Risk Factors; D018805:Sepsis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: Laos; Neonatal sepsis; S. aureus; developing countries; post-partum behavior
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