title: Noncovalent intracellular drug delivery of hydrophobic drugs on Au NPs.
abstract: The successful delivery of hydrophobic drugs to cellular targets continues to present challenges to the pharmaceutical industry. The advances made by nanotechnology have generated new avenues for selectively loading, delivering, and targeting these drugs to their biological targets without compromising efficacy. Here, we describe how gold nanoparticles (Au NPs) functionalized with polyethylene glycol (PEG) can be evaluated for the delivery of hydrophobic drugs in aqueous systems. Specifically, we describe Au NP synthesis, ligand exchange, and delivery evaluation at-the-bench for screening of potential drug candidates.
authors.affiliation: Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Tennyson
authors.initials: T
authors.lastname: Doane
authors.forename: Clemens
authors.initials: C
authors.lastname: Burda
mesh_terms: D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D006046:Gold / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry; D012996:Solutions; D014867:Water
chemical_list: D012996:Solutions; D014867:Water; D011092:Polyethylene Glycols; D006046:Gold