title: Aerobic exercise attenuates inhibitory avoidance memory deficit induced by paradoxical sleep deprivation in rats.
abstract: The deleterious effects of paradoxical sleep deprivation (SD) on memory processes are well documented. Physical exercise improves many aspects of brain functions and induces neuroprotection. In the present study, we investigated the influence of 4 weeks of treadmill aerobic exercise on both long-term memory and the expression of synaptic proteins (GAP-43, synapsin I, synaptophysin, and PSD-95) in normal and sleep-deprived rats. Adult Wistar rats were subjected to 4 weeks of treadmill exercise training for 35 min, five times per week. Twenty-four hours after the last exercise session, the rats were sleep-deprived for 96 h using the modified multiple platform method. To assess memory after SD, all animals underwent training for the inhibitory avoidance task and were tested 24h later. The aerobic exercise attenuated the long-term memory deficit induced by 96 h of paradoxical SD. Western blot analysis of the hippocampus revealed increased levels of GAP-43 in exercised rats. However, the expression of synapsin I, synaptophysin, and PSD-95 was not modified by either exercise or SD. Our results suggest that an aerobic exercise program can attenuate the deleterious effects of SD on long-term memory and that this effect is not directly related to changes in the expression of the pre- and post-synaptic proteins analyzed in the study.
authors.affiliation: Department of Physiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: Jansen
authors.initials: J
authors.lastname: Fernandes
authors.forename: Luiz Guilherme Zaccaro
authors.initials: LG
authors.lastname: Baliego
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Peixinho-Pena
authors.forename: Alexandre Aparecido
authors.initials: AA
authors.lastname: de Almeida
authors.forename: Daniel Paulino
authors.initials: DP
authors.lastname: Venancio
authors.forename: Fulvio Alexandre
authors.initials: FA
authors.lastname: Scorza
authors.forename: Marco Tulio
authors.initials: MT
authors.lastname: de Mello
authors.forename: Ricardo Mario
authors.initials: RM
authors.lastname: Arida
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D000076122:Disks Large Homolog 4 Protein; D005080:Exercise Test; D019922:GAP-43 Protein / Q000378:metabolism; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000378:metabolism; D007266:Inhibition, Psychological; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008569:Memory Disorders / Q000209:etiology* / Q000534:rehabilitation*; D010805:Physical Conditioning, Animal / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000150:complications*; D016704:Synapsins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D000076122:Disks Large Homolog 4 Protein; C501449:Dlg4 protein, rat; D019922:GAP-43 Protein; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D016704:Synapsins; D016708:Synaptophysin
keywords: Hippocampus; Memory; Neuroplasticity; Sleep deprivation; Synaptic proteins; Treadmill exercise