title: Increasing prevalence of blaOXA-23-carrying Acinetobacter baumannii and the emergence of blaOXA-182-carrying Acinetobacter nosocomialis in Korea.
abstract: Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent bla(OXA) genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of bla(OXA) genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of bla(OXA)-23-like, ISAba1-associated bla(OXA-51)-like, and bla(OXA-182) genes were 44.0%, 49.7%, and 5.1%, respectively. The bla(OXA-58)-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with bla(OXA-23)-like genes and a decrease in isolates harboring ISAba1-associated bla(OXA-51)-like genes have been observed since the mid-2000s. The bla(OXA-23)-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that bla(OXA-182)-carrying Acinetobacter nosocomialis has emerged and caused outbreaks of infection.
authors.affiliation: Severance Hospital, Yonsei University College of Medicine, Seoul 120-752, South Korea; National Health Insurance Service Ilsan Hospital, Goyang 410-719, South Korea.
authors.forename: Yangsoon
authors.initials: Y
authors.lastname: Lee
authors.forename: Young-Ree
authors.initials: YR
authors.lastname: Kim
authors.forename: Jayoung
authors.initials: J
authors.lastname: Kim
authors.forename: Yeon-Joon
authors.initials: YJ
authors.lastname: Park
authors.forename: Wonkeun
authors.initials: W
authors.lastname: Song
authors.forename: Jong-Hee
authors.initials: JH
authors.lastname: Shin
authors.forename: Young
authors.initials: Y
authors.lastname: Uh
authors.forename: Kyutaeg
authors.initials: K
authors.lastname: Lee
authors.forename: Seong Hee
authors.initials: SH
authors.lastname: Lee
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Cho
authors.forename: Dongeun
authors.initials: D
authors.lastname: Yong
authors.forename: Seok Hoon
authors.initials: SH
authors.lastname: Jeong
authors.forename: Kyungwon
authors.initials: K
authors.lastname: Lee
authors.forename: Yunsop
authors.initials: Y
authors.lastname: Chong
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010802:Phylogeny; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases
keywords: Acinetobacter baumannii; Acinetobacter nosocomialis; bla(OXA-182); bla(OXA-23)