title: A comparison of deconvolution and the Rutland-Patlak plot in parenchymal renal uptake rate.
abstract: BACKGROUND
  Deconvolution and the Rutland-Patlak (R-P) plot are two of the most commonly used methods for analyzing dynamic radionuclide renography. Both methods allow estimation of absolute and relative renal uptake of radiopharmaceutical and of its rate of transit through the kidney.
  
  
  METHODS
  Seventeen patients (32 kidneys) were referred for further evaluation by renal scanning. All patients were positioned supine with their backs to the scintillation gamma camera, so that the kidneys and the heart are both in the field of view. Approximately 5-7 mCi of (99m)Tc-DTPA (diethylinetriamine penta-acetic acid) in about 0.5 ml of saline is injected intravenously and sequential 20 s frames were acquired, the study on each patient lasts for approximately 20 min. The time-activity curves of the parenchymal region of interest of each kidney, as well as the heart were obtained for analysis. The data were then analyzed with deconvolution and the R-P plot.
  
  
  RESULTS
  A strong positive association (n = 32; r = 0.83; R (2) = 0.68) was found between the values that obtained by applying the two methods. Bland-Altman statistical analysis demonstrated that ninety seven percent of the values in the study (31 cases from 32 cases, 97% of the cases) were within limits of agreement (mean ± 1.96 standard deviation).
  
  
  CONCLUSIONS
  We believe that R-P analysis method is expected to be more reproducible than iterative deconvolution method, because the deconvolution technique (the iterative method) relies heavily on the accuracy of the first point analyzed, as any errors are carried forward into the calculations of all the subsequent points, whereas R-P technique is based on an initial analysis of the data by means of the R-P plot, and it can be considered as an alternative technique to find and calculate the renal uptake rate.
authors.affiliation: Department of Physics, University of Jordan, Amman, Jordan.
authors.forename: Issa A
authors.initials: IA
authors.lastname: Al-Shakhrah
keywords: Iterative deconvolution; Rutland-Patlak plot; renal retention function; renal uptake; renogram
references.citation: Q J Nucl Med. 1997 Mar;41(1):42-5
references.pmid: 9195852
references.citation: Eur J Nucl Med. 1978 Apr 1;3(2):145-6
references.pmid: 750202
references.citation: J Nucl Med. 1996 Nov;37(11):1876-82
references.pmid: 8917196
references.citation: Nucl Med Commun. 2003 Jan;24(1):101-6
references.pmid: 12501026
references.citation: Br J Urol. 1978 Dec;50(7):433-6
references.pmid: 753492
references.citation: Br J Radiol. 1982 Jun;55(654):419-33
references.pmid: 7049298
references.citation: Br J Radiol. 1975 Jun;48(570):481-6
references.pmid: 1227704
references.citation: Med Biol Eng. 1975 Jan;13(1):123-5
references.pmid: 1195794
references.citation: Radiat Med. 1989 Sep-Oct;7(5):236-42
references.pmid: 2697894
references.citation: Clin Sci (Lond). 1981 Oct;61(4):385-9
references.pmid: 7285491
references.citation: AJR Am J Roentgenol. 1982 Mar;138(3):565-70
references.pmid: 7039273
references.citation: Transplant Proc. 1995 Aug;27(4):2221
references.pmid: 7652780
references.citation: Nuklearmedizin. 1990 Aug;29(4):170-6
references.pmid: 2145552
references.citation: J Nucl Med. 1993 May;34(5):845-8
references.pmid: 8478722
references.citation: Br J Radiol. 1979 Feb;52(614):134-7
references.pmid: 427364
references.citation: Phys Med Biol. 1974 Jul;19(4):546-9
references.pmid: 4445227
references.citation: Nucl Med Commun. 2002 Jan;23(1):91-6
references.pmid: 11748443
references.citation: Nucl Med Commun. 1994 Sep;15(9):669-72
references.pmid: 7816377
references.citation: J Nucl Med. 1976 May;17(5):352-5
references.pmid: 1262936
references.citation: Eur J Nucl Med. 1985;11(6-7):265-74
references.pmid: 3908109
references.citation: Clin Sci Mol Med. 1974 Oct;47(4):317-30
references.pmid: 4426164
references.citation: J Nucl Med. 1999 Sep;40(9):1503-7
references.pmid: 10492372
references.citation: J Nucl Med. 1996 Feb;37(2):403-4
references.pmid: 8667088
references.citation: Clin Sci Mol Med. 1978 Sep;55(3):277-83
references.pmid: 699503
references.citation: Eur J Nucl Med. 1996 Nov;23(11):1541-6
references.pmid: 8854856
references.citation: J Nucl Med. 1995 Jan;36(1):147-52
references.pmid: 7799069
references.citation: Eur J Nucl Med. 1995 Dec;22(12):1372-8
references.pmid: 8586081
references.citation: Br J Urol. 1981 Dec;53(6):500-3
references.pmid: 7317730
references.citation: J Cereb Blood Flow Metab. 1983 Mar;3(1):1-7
references.pmid: 6822610
references.citation: Nucl Med Commun. 2001 Nov;22(11):1255-60
references.pmid: 11606893
references.citation: Nucl Med Commun. 1985 Jan;6(1):11-20
references.pmid: 3916534