title: Can matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF) enhance antimicrobial stewardship efforts in the acute care setting?
abstract: We evaluated 222 hospitalized patients whose clinical isolates were tested using standard methods and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF). MALDI-TOF could have reduced time to appropriate therapy for 28.8% and 44.6% patients based on the treating physician's choices and stewardship team recommendations, respectively. Clinicians should be aware of scenarios in which MALDI-TOF can optimize antibiotic therapy.
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA. ptamma1@jhmi.edu
authors.forename: Pranita D
authors.initials: PD
authors.lastname: Tamma
authors.forename: Kennard
authors.initials: K
authors.lastname: Tan
authors.forename: Veronique R
authors.initials: VR
authors.lastname: Nussenblatt
authors.forename: Alison E
authors.initials: AE
authors.lastname: Turnbull
authors.forename: Karen C
authors.initials: KC
authors.lastname: Carroll
authors.forename: Sara E
authors.initials: SE
authors.lastname: Cosgrove
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D001424:Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D017723:Drug Utilization Review / Q000379:methods*; D006801:Humans; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents