title: Reversion and conversion of interferon-γ release assay results in HIV-1-infected individuals.
abstract: In this prospective study, human immunodeficiency virus type 1 (HIV-1)-infected subjects underwent QuantiFERON-TB Gold In-Tube interferon-γ release assay (IGRA) testing at baseline and after 24 months in a low tuberculosis incidence country. Concordant baseline and follow-up results were observed in 86% (n = 686 of 794) of subjects. IGRA conversions occurred in 9% (n = 63 of 718), whereas IGRA reversions were seen in 33% (n = 25 of 76) of individuals. Of the 10 active tuberculosis cases during follow-up, 5 had concordant positive IGRA results and 2 were IGRA converters. Although the clinical significance of IGRA conversions and reversions remains to be established, repeated IGRA testing seems to be of value in HIV-1-infected individuals.
authors.affiliation: Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases (DIAID).
authors.forename: Maximilian C
authors.initials: MC
authors.lastname: Aichelburg
authors.forename: Thomas
authors.initials: T
authors.lastname: Reiberger
authors.forename: Florian
authors.initials: F
authors.lastname: Breitenecker
authors.forename: Mattias
authors.initials: M
authors.lastname: Mandorfer
authors.forename: Athanasios
authors.initials: A
authors.lastname: Makristathis
authors.forename: Armin
authors.initials: A
authors.lastname: Rieger
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications*; D015497:HIV-1; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D059425:Interferon-gamma Release Tests / Q000379:methods; D008297:Male; D011446:Prospective Studies; D014376:Tuberculosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*
chemical_list: D007371:Interferon-gamma
keywords: conversion; human immunodeficiency virus type 1; interferon-gamma release assay; reversion; serial testing