title: Recognition and control of the progression of age-related hearing loss.
abstract: Recent breakthroughs have provided notable insights into both the pathogenesis and therapeutic strategies for age-related hearing loss (ARHL). Simultaneously, these breakthroughs enhance our knowledge about this neurodegenerative disease and raise the question of whether the disorder is preventable or even treatable. Discoveries relating to ARHL have revealed a unique link between ARHL and the underlying pathologies. Therefore, we need to better understand the pathogenesis or the mechanism of ARHL and learn how to take full advantage of various therapeutic strategies to prevent the progression of ARHL.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University , Changsha, Hunan, P.R. China .
authors.forename: Hong Miao
authors.initials: HM
authors.lastname: Ren
authors.forename: Jihao
authors.initials: J
authors.lastname: Ren
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
mesh_terms: D000375:Aging / Q000502:physiology*; D017209:Apoptosis; D018450:Disease Progression; D034381:Hearing Loss / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans; D009154:Mutation; D010085:Oxidative Phosphorylation
references.citation: J Biol Chem. 1987 Apr 25;262(12):5488-91
references.pmid: 3571220
references.citation: J Biol Chem. 2002 Apr 19;277(16):14127-34
references.pmid: 11836241
references.citation: Hear Res. 2010 Jun 1;264(1-2):79-85
references.pmid: 19772906
references.citation: Science. 2009 Jul 10;325(5937):201-4
references.pmid: 19590001
references.citation: Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12922-7
references.pmid: 15328414
references.citation: Mamm Genome. 2006 Aug;17(8):841-50
references.pmid: 16897347
references.citation: Genomics. 2008 Oct;92(4):219-25
references.pmid: 18662770
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18769-70
references.pmid: 16365283
references.citation: J Histochem Cytochem. 1995 Oct;43(10):981-91
references.pmid: 7560888
references.citation: Hear Res. 2008 Jul;241(1-2):26-33
references.pmid: 18508213
references.citation: Genes Dev. 2003 Feb 1;17(3):313-21
references.pmid: 12569120
references.citation: Mol Ther. 2006 Apr;13(4):644-70
references.pmid: 16481219
references.citation: Exp Gerontol. 1997 Jan-Apr;32(1-2):181-95
references.pmid: 9088915
references.citation: Nat Neurosci. 2005 Feb;8(2):149-55
references.pmid: 15643426
references.citation: Cell Stem Cell. 2013 Feb 7;12(2):152-65
references.pmid: 23395443
references.citation: Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14013-8
references.pmid: 22891314
references.citation: Hear Res. 2011 Aug;278(1-2):106-12
references.pmid: 21640179
references.citation: Genomics. 1997 Sep 15;44(3):266-72
references.pmid: 9325047
references.citation: FASEB J. 2003 Mar;17(3):494-6
references.pmid: 12514107
references.citation: J Am Geriatr Soc. 1972 Apr;20(4):145-7
references.pmid: 5016631
references.citation: Ann N Y Acad Sci. 1999 Nov 28;884:381-8
references.pmid: 10842608
references.citation: Cell Transplant. 2012;21(4):763-71
references.pmid: 22305181
references.citation: Nat Neurosci. 2000 Jun;3(6):580-6
references.pmid: 10816314
references.citation: Int J Clin Exp Pathol. 2013;6(2):230-41
references.pmid: 23330008
references.citation: Diabetes. 2013 Mar;62(3):672-8
references.pmid: 23431006
references.citation: Hear Res. 2011 Oct;280(1-2):201-8
references.pmid: 21664445
references.citation: Genes Dev. 2001 Nov 15;15(22):2922-33
references.pmid: 11711427
references.citation: Genomics. 2000 Dec 1;70(2):171-80
references.pmid: 11112345
references.citation: J Neurosci. 2011 Nov 16;31(46):16541-9
references.pmid: 22090480
references.citation: Cell. 2006 Dec 15;127(6):1109-22
references.pmid: 17112576
references.citation: Physiology (Bethesda). 2006 Oct;21:336-45
references.pmid: 16990454
references.citation: Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11800-6
references.pmid: 11050212
references.citation: Nature. 2012 Nov 15;491(7424):374-83
references.pmid: 23151580
references.citation: Hear Res. 2005 Nov;209(1-2):76-85
references.pmid: 16055286
references.citation: Free Radic Biol Med. 2003 Apr 1;34(7):873-80
references.pmid: 12654476
references.citation: Cold Spring Harb Symp Quant Biol. 2007;72:483-8
references.pmid: 18419308
references.citation: Curr Opin Cell Biol. 2006 Dec;18(6):677-84
references.pmid: 17046227
references.citation: Biochem Biophys Res Commun. 2006 May 26;344(1):425-30
references.pmid: 16616000
references.citation: J Assoc Res Otolaryngol. 2000 Nov;1(3):243-54
references.pmid: 11545230
references.citation: Acta Otolaryngol. 1996 Jan;116(1):17-24
references.pmid: 8820345
references.citation: Int J Pediatr Otorhinolaryngol. 2000 Nov 30;56(1):45-51
references.pmid: 11074115
references.citation: Nature. 2012 Feb 29;483(7387):S22-6
references.pmid: 22378125
references.citation: Mutat Res. 1992 Sep;275(3-6):181-93
references.pmid: 1383760
references.citation: Nat Neurosci. 2004 Sep;7(9):974-81
references.pmid: 15286790
references.citation: Adv Otorhinolaryngol. 2009;66:64-86
references.pmid: 19494573
references.citation: Exp Gerontol. 2011 Jun;46(6):413-25
references.pmid: 21211561
references.citation: Ann Otol Rhinol Laryngol. 1993 Jan;102(1 Pt 2):1-16
references.pmid: 8420477
references.citation: Mutat Res. 2008 Apr 2;640(1-2):38-45
references.pmid: 18242646
references.citation: Bone Marrow Transplant. 2001 Aug;28(4):323-8
references.pmid: 11571502
references.citation: Nat Neurosci. 2011 Feb;14(2):246-51
references.pmid: 21170056
references.citation: Neurobiol Dis. 2013 Jul;55:26-35
references.pmid: 23537713
references.citation: Cell Death Differ. 2006 Aug;13(8):1291-5
references.pmid: 16763618
references.citation: Nat Genet. 2001 Feb;27(2):191-4
references.pmid: 11175788
references.citation: Cereb Cortex. 1997 Mar;7(2):157-65
references.pmid: 9087823
references.citation: Annu Rev Genet. 2005;39:359-407
references.pmid: 16285865
references.citation: Gene. 2012 May 15;499(2):309-17
references.pmid: 22326520
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1751-6
references.pmid: 18218777
references.citation: Arch Neurol. 2001 Nov;58(11):1885-8
references.pmid: 11708999
references.citation: Acta Otolaryngol. 2011 Nov;131(11):1160-4
references.pmid: 21970786
references.citation: Exp Gerontol. 2011 Sep;46(9):716-22
references.pmid: 21586320
references.citation: Free Radic Biol Med. 2003 Jun 15;34(12):1507-16
references.pmid: 12788471
references.citation: Neurobiol Aging. 1999 Jan-Feb;20(1):1-8
references.pmid: 10466888
references.citation: Hear Res. 2007 Apr;226(1-2):194-202
references.pmid: 16843623
references.citation: J Histochem Cytochem. 1997 Jun;45(6):773-8
references.pmid: 9199662
references.citation: Hear Res. 1993 Feb;65(1-2):125-32
references.pmid: 8458745
references.citation: Curr Opin Neurobiol. 2009 Aug;19(4):395-401
references.pmid: 19683914
references.citation: Nat Neurosci. 2011 Jul 31;14(9):1189-94
references.pmid: 21804538
references.citation: J Neurosci Res. 2008 Nov 1;86(14):3075-85
references.pmid: 18543340
references.citation: Cell. 2010 Nov 24;143(5):802-12
references.pmid: 21094524
references.citation: Science. 1989 Apr 21;244(4902):346-9
references.pmid: 2711184
references.citation: Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13900-5
references.pmid: 20643928
references.citation: Physiology (Bethesda). 2006 Apr;21:103-14
references.pmid: 16565476
references.citation: Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59
references.pmid: 18097445
references.citation: Expert Opin Investig Drugs. 2004 Oct;13(10):1327-38
references.pmid: 15461561
references.citation: Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7370-4
references.pmid: 1502147
references.citation: Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4333-8
references.pmid: 10760300
references.citation: Mol Cell. 2000 Dec;6(6):1389-99
references.pmid: 11163212
references.citation: Nature. 2006 Nov 16;444(7117):337-42
references.pmid: 17086191
references.citation: Exp Gerontol. 2000 May;35(3):299-305
references.pmid: 10832051
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19432-7
references.pmid: 19901338
references.citation: Mutat Res. 1994 Aug;316(2):69-78
references.pmid: 7521004
references.citation: J Assoc Res Otolaryngol. 2010 Sep;11(3):419-34
references.pmid: 20372958
references.citation: Neurobiol Aging. 2007 Oct;28(10):1613-22
references.pmid: 16890326
references.citation: J Neurosci. 2010 Jul 21;30(29):9782-7
references.pmid: 20660260
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18724-9
references.pmid: 16344488
references.citation: EMBO J. 2006 Nov 1;25(21):5071-82
references.pmid: 17036048
references.citation: Psychol Rev. 1996 Jul;103(3):403-28
references.pmid: 8759042
references.citation: FEBS Lett. 2007 Feb 6;581(3):483-8
references.pmid: 17240370
references.citation: Gerontology. 2010;56(3):351-8
references.pmid: 20090297
references.citation: J Neurosci. 2006 Feb 1;26(5):1378-85
references.pmid: 16452661
references.citation: Acta Otolaryngol Suppl. 2004 May;(552):16-24
references.pmid: 15219042
references.citation: Neurobiol Aging. 2009 Oct;30(10):1693-705
references.pmid: 18280008
references.citation: Laryngoscope. 1987 Aug;97(8 Pt 1):984-91
references.pmid: 3613802
references.citation: Nat Genet. 1992 Dec;2(4):324-9
references.pmid: 1303288
references.citation: Philos Trans R Soc Lond B Biol Sci. 2009 Feb 12;364(1515):301-11
references.pmid: 18977731
references.citation: Hear Res. 2006 Feb;212(1-2):128-39
references.pmid: 16426780
references.citation: Ann Neurol. 1993 Oct;34(4):609-16
references.pmid: 8215249
references.citation: Recent Pat CNS Drug Discov. 2008 Jan;3(1):61-9
references.pmid: 18221243
references.citation: Nature. 2006 Oct 12;443(7112):651-7
references.pmid: 17035995
references.citation: Curr Opin Neurol. 2002 Feb;15(1):11-5
references.pmid: 11796945
references.citation: Prog Neurobiol. 2012 May;97(2):101-26
references.pmid: 22033150
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17993-8
references.pmid: 16332961
references.citation: Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29
references.pmid: 12838335
references.citation: Am J Otol. 1997 Jul;18(4):449-53
references.pmid: 9233484
references.citation: Biochem Biophys Res Commun. 2007 Mar 30;355(1):117-21
references.pmid: 17291455
references.citation: Otolaryngol Head Neck Surg. 2003 Nov;129(5):463-70
references.pmid: 14595267
references.citation: Otolaryngol Head Neck Surg. 2002 Sep;127(3):138-44
references.pmid: 12297801
references.citation: Lancet. 1989 Mar 25;1(8639):642-5
references.pmid: 2564461
references.citation: J Clin Invest. 2010 Jan;120(1):29-40
references.pmid: 20051634
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18770-5
references.pmid: 19047635
references.citation: Nat Genet. 2003 Sep;35(1):21-3
references.pmid: 12910270
references.citation: Cell. 2005 Feb 25;120(4):483-95
references.pmid: 15734681
references.citation: Proc Natl Acad Sci U S A. 1991 May 1;88(9):3633-6
references.pmid: 1673789
references.citation: Nature. 1959 Dec 12;184:1851-4
references.pmid: 13820680
references.citation: Laryngoscope. 2000 May;110(5 Pt 1):727-38
references.pmid: 10807352
references.citation: Nature. 2012 Oct 11;490(7419):278-82
references.pmid: 22972191
references.citation: Eur Arch Otorhinolaryngol. 2010 Aug;267(8):1179-91
references.pmid: 20464410
references.citation: J Gerontol. 1994 Nov;49(6):B247-54
references.pmid: 7963272
references.citation: Hear Res. 2002 Mar;165(1-2):1-9
references.pmid: 12031509
references.citation: Brain Res. 2004 Nov 26;1028(1):92-104
references.pmid: 15518646
references.citation: Aging Cell. 2007 Jun;6(3):285-96
references.pmid: 17517039
references.citation: Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5785-90
references.pmid: 22451939
references.citation: Nature. 2002 Oct 10;419(6907):634-7
references.pmid: 12374983
references.citation: J Comp Neurol. 1999 Oct 11;413(1):101-12
references.pmid: 10464373
references.citation: Chem Rev. 2006 Jun;106(6):1995-2044
references.pmid: 16771441
references.citation: Med Electron Microsc. 2000;33(2):51-6
references.pmid: 11810458
references.citation: Trends Neurosci. 1999 Jun;22(6):263-9
references.pmid: 10354604
references.citation: J Agric Food Chem. 2002 May 22;50(11):3337-40
references.pmid: 12010007
references.citation: Neurobiol Learn Mem. 2009 May;91(4):382-92
references.pmid: 19028592
references.citation: J Comp Neurol. 2004 Feb 9;469(3):377-90
references.pmid: 14730589
references.citation: Nat Neurosci. 2011 Jun;14(6):791-6
references.pmid: 21552275
references.citation: Eur J Neurosci. 2007 Jul;26(1):134-41
references.pmid: 17573922
references.citation: Nat Neurosci. 2005 Sep;8(9):1148-50
references.pmid: 16116456
references.citation: Nature. 1989 Oct 5;341(6241):397-404
references.pmid: 2677742
references.citation: Proc Natl Acad Sci U S A. 2012 May 22;109(21):8292-7
references.pmid: 22566618
references.citation: J Assoc Res Otolaryngol. 2007 Dec;8(4):422-34
references.pmid: 17674100
references.citation: PLoS One. 2013;8(2):e55092
references.pmid: 23390514
references.citation: Curr Opin Neurobiol. 1996 Aug;6(4):533-41
references.pmid: 8794105
references.citation: Hear Res. 2012 Jan;283(1-2):80-8
references.pmid: 22138310
references.citation: Lancet Neurol. 2009 May;8(5):491-500
references.pmid: 19375666
references.citation: Biophys J. 2000 Nov;79(5):2572-82
references.pmid: 11053131
references.citation: Brain Pathol. 2012 Jan;22(1):110-6
references.pmid: 22150926
references.citation: Antioxid Redox Signal. 2012 Feb 1;16(3):263-74
references.pmid: 21923553
references.citation: Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):181-6
references.pmid: 23248276
references.citation: Hear Res. 1998 Apr;118(1-2):1-12
references.pmid: 9606057
references.citation: Neurobiol Aging. 2007 Oct;28(10):1605-12
references.pmid: 16920227
references.citation: Cell Reprogram. 2013 Feb;15(1):43-54
references.pmid: 23379581
references.citation: Genomics. 2002 Nov;80(5):461-4
references.pmid: 12408962
references.citation: Biochem Biophys Res Commun. 2004 Nov 26;324(4):1283-8
references.pmid: 15504353
references.citation: Neurosci Lett. 1997 Dec 12;239(1):1-4
references.pmid: 9547159
references.citation: Hear Res. 2010 Jun 1;264(1-2):93-7
references.pmid: 19854255