title: Sensory nerves are frequently involved in the spectrum of fisher syndrome.
abstract: BACKGROUND
  Differing patterns of neurophysiological abnormalities have been reported in patients with Fisher syndrome. Fisher syndrome is rare, and few series have incorporated prospective serial studies to define the natural history of nerve conduction studies in Guillain-Barré syndrome.
  
  
  METHODS
  In an ongoing prospective study of Guillain-Barré syndrome patients, patients who presented with Fisher syndrome and its spectrum of illness were assessed through serial neurological examinations, nerve conduction studies, and serological testing of IgG against gangliosides and ganglioside complexes.
  
  
  RESULTS
  Of the 36 Guillain-Barré syndrome patients identified within 2 years, 17 had features of Fisher syndrome. Serial nerve conduction studies detected significant abnormalities in sensory nerve action potential amplitude in 94% of patients associated with 2 patterns of recovery-non-demyelinating reversible distal conduction failure and axonal regeneration. Similar changes were seen in motor nerves of 5 patients.
  
  
  CONCLUSIONS
  Patients with the Fisher syndrome spectrum of illness have significant sensory involvement, which may only be evident with serial neurophysiological studies.
authors.affiliation: Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors.forename: Nortina
authors.initials: N
authors.lastname: Shahrizaila
authors.forename: Khean J
authors.initials: KJ
authors.lastname: Goh
authors.forename: Norito
authors.initials: N
authors.lastname: Kokubun
authors.forename: Ai H
authors.initials: AH
authors.lastname: Tan
authors.forename: Cheng Y
authors.initials: CY
authors.lastname: Tan
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology*; D011446:Prospective Studies; D011984:Sensory Receptor Cells / Q000473:pathology* / Q000502:physiology*; D055815:Young Adult
keywords: Fisher syndrome; Guillain-Barré syndrome; anti-ganglioside antibody; nerve conduction study; sensory neuropathy