title: Genetic variants at 5p15 are associated with risk and early onset of gastric cancer in Chinese populations.
abstract: Genetic variants at 5p15 have been associated with multiple cancers risk, suggesting pleiotropic effect on cancer. We hypothesized that genetic variants at 5p15 are important in the development of gastric cancer. To test this hypothesis, we evaluated the associations of genetic variants at 5p15 with gastric cancer based on our existing genome-wide association study (GWAS) data set of gastric cancer (1006 cases and 2273 controls), and replicated two promising loci in an independent case-control study with 1681 gastric cancer cases and 1705 controls in a Chinese population. We found that rs10052016 was consistently associated with gastric cancer risk in GWAS discovery stage (odds ratio [OR] = 0.69, 95% confidence interval [95% CI] = 0.55-0.87) and replication stage (OR = 0.80, 95% CI = 0.68-0.94). After combining these two studies, we found that the G allele of rs10052016 (at 132 kb upstream of TERT) was significantly associated with a decreased risk of gastric cancer (OR = 0.76, 95% CI = 0.67-0.87, P = 5.35 × 10(-5)). Moreover, the protective allele of rs10052016-G was also significantly associated with late onset of gastric cancer (P = 0.013). In summary, these findings indicate that genetic variants at 5p15 may contribute to gastric cancer susceptibility and may further advance our understanding of 5p15 locus in cancer development.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China.
authors.forename: Jiangbo
authors.initials: J
authors.lastname: Du
authors.forename: Yaochu
authors.initials: Y
authors.lastname: Xu
authors.forename: Juncheng
authors.initials: J
authors.lastname: Dai
authors.forename: Chuanli
authors.initials: C
authors.lastname: Ren
authors.forename: Chen
authors.initials: C
authors.lastname: Zhu
authors.forename: Ningbin
authors.initials: N
authors.lastname: Dai
authors.forename: Hongxia
authors.initials: H
authors.lastname: Ma
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
authors.forename: Dongxin
authors.initials: D
authors.lastname: Lin
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
authors.forename: Guangfu
authors.initials: G
authors.lastname: Jin
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D015996:Survival Rate; D019098:Telomerase / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C509186:TERT protein, human; D019098:Telomerase