title: Acute eosinophilic myocarditis with dramatic response to steroid therapy: the central role of echocardiography in diagnosis and follow-up.
abstract: Acute eosinophilic myocarditis is a rare cause of acute heart failure. We present the case of a 32-year-old woman who had presumptive eosinophilic myocarditis as part of a generalized hypersensitivity reaction (Drug Rash with Eosinophilia and Systemic Symptoms [DRESS] syndrome) that exhibited a dramatic response to steroid therapy. We highlight the central role of 2-dimensional and tissue-Doppler echocardiography in the diagnosis of myocarditis and the serial evaluation of left ventricular systolic and diastolic function in this setting.
authors.affiliation: Cardiology Division, Kantonsspital, CH-9007 St. Gallen, Switzerland.
authors.forename: Manuela
authors.initials: M
authors.lastname: Eppenberger
authors.forename: Dietrich
authors.initials: D
authors.lastname: Hack
authors.forename: Peter
authors.initials: P
authors.lastname: Ammann
authors.forename: Hans
authors.initials: H
authors.lastname: Rickli
authors.forename: Micha T
authors.initials: MT
authors.lastname: Maeder
mesh_terms: D000208:Acute Disease; D000328:Adult; D003971:Diastole; D063926:Drug Hypersensitivity Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D015150:Echocardiography, Doppler; D018618:Echocardiography, Doppler, Color; D018619:Echocardiography, Doppler, Pulsed; D004802:Eosinophilia / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D009205:Myocarditis / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D011237:Predictive Value of Tests; D020127:Recovery of Function; D013256:Steroids / Q000627:therapeutic use*; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D013256:Steroids
keywords: Cardiomyopathy, infiltrative; Doppler, pulsed; drug complications; echocardiography, two-dimensional, transthoracic; eosinophils; myocarditis
references.citation: Circ J. 2010 Jun;74(6):1205-13
references.pmid: 20453384
references.citation: N Engl J Med. 2007 Nov 22;357(21):2167-78
references.pmid: 18032767
references.citation: Heart. 2011 May;97(9):709-14
references.pmid: 21134904
references.citation: Int J Cardiol. 2008 May 23;126(2):279-80
references.pmid: 17466393
references.citation: Heart Fail Clin. 2005 Oct;1(3):419-29
references.pmid: 17386864
references.citation: Can J Cardiol. 2006 Dec;22(14):1233-7
references.pmid: 17151774
references.citation: J Am Soc Echocardiogr. 2009 Feb;22(2):107-33
references.pmid: 19187853
references.citation: J Am Soc Echocardiogr. 2012 Mar;25(3):294-303
references.pmid: 22101088
references.citation: J Am Acad Dermatol. 2012 Jun;66(6):e229-36
references.pmid: 21658796
references.citation: J Am Coll Cardiol. 2009 Mar 17;53(11):905-18
references.pmid: 19281919
references.citation: J Am Coll Cardiol. 2010 Apr 27;55(17):1769-79
references.pmid: 20413025
references.citation: J Am Coll Cardiol. 2009 Apr 28;53(17):1475-87
references.pmid: 19389557