title: Fluorescence turn-on chemodosimeter for rapid detection of mercury (II) ions in aqueous solution and blood from mice with toxicosis.
abstract: The heavy metal mercury (Hg) is a threat to the health of people and wildlife in many environments. Among various chemical forms, Hg(2+) salts are usually more toxic than their counterparts because of their greater solubility in water; thus, they are more readily absorbed from the gastrointestinal tract into circulation. Therefore, new chemical receptors for detecting Hg(2+) ions in circulation are needed. In this study, we developed a rhodamine-based turn-on fluorescence probe to monitor Hg(2+) in aqueous solution and in blood of mice with toxicosis. The chemodosimeter responds to Hg(2+) ions stoichiometrically, rapidly, and irreversibly at room temperature as a result of a chemical reaction that produces strongly fluorescent oxadiazole. The new fluorescent probe shows good fluorescence response, with high sensitivity and selectivity, toward Hg(2+) ions in aqueous solution and in blood from mice with toxicosis and facilitates the naked-eye detection of Hg(2+) ions.
authors.affiliation: Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
authors.forename: Wei-Yong
authors.initials: WY
authors.lastname: Liu
authors.forename: Shi-Li
authors.initials: SL
authors.lastname: Shen
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Li
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Miao
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Zhao
mesh_terms: D000818:Animals; D005453:Fluorescence; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008628:Mercury / Q000032:analysis* / Q000097:blood / Q000633:toxicity; D008630:Mercury Poisoning / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D021241:Spectrometry, Mass, Electrospray Ionization; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D008628:Mercury
keywords: Fluorescence probe; Hg(2+) ions; Rhodamine B; Toxicosis mice