title: A Comparison of 2 L of Polyethylene Glycol and 45 mL of Sodium Phosphate versus 4 L of Polyethylene Glycol for Bowel Cleansing: A Prospective Randomized Trial.
abstract: OBJECTIVE
  Polyethylene glycol (PEG)-based gut lavage solutions are safe and effective, but require the intake of large volumes of fluid. The use of 2 L PEG plus 45 mL sodium phosphate (PEG2 plus NaP) was compared with 4 L PEG (PEG4) for bowel cleansing before colonoscopy.
  
  
  METHODS
  Patients were randomized to the PEG2 plus NaP group or PEG4 group between January 1, 2009 and March 31, 2010. One hundred and thirty patients were included in the PEG2 plus NaP group, and 141 patients in the PEG4 group.
  
  
  RESULTS
  The qualities of the bowel preparation, based on the Ottawa scale were not significantly different between the groups (4.8±2.25 for the PEG2 plus NaP group vs. 5.11±2.26 for the PEG4). In addition, there were no significant differences in side effects. Laboratory findings after bowel preparation, including electrolyte, phosphorus and creatinine levels, were within the normal ranges in both groups.
  
  
  CONCLUSIONS
  PEG2 plus NaP provides good cleansing that is similar to PEG4, but with a lower volume. However, because PEG2 plus NaP can cause serious side effects such as calcium deposition in the kidneys (i.e., nephrocalcinosis), this solution might be considered for the outpatients who cannot tolerate PEG4.
authors.affiliation: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Suh Eun
authors.initials: SE
authors.lastname: Bae
authors.forename: Kyung-Jo
authors.initials: KJ
authors.lastname: Kim
authors.forename: Jun Bum
authors.initials: JB
authors.lastname: Eum
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Yang
authors.forename: Byong Duk
authors.initials: BD
authors.lastname: Ye
authors.forename: Jeong-Sik
authors.initials: JS
authors.lastname: Byeon
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Myung
authors.forename: Suk-Kyun
authors.initials: SK
authors.lastname: Yang
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Kim
keywords: Cathartics; Colonoscopy; Polyethylene glycols; Sodium phosphate
references.citation: Endoscopy. 2005 Jun;37(6):537-41
references.pmid: 15933926
references.citation: Gastrointest Endosc. 2002 Dec;56(6):895-902
references.pmid: 12447305
references.citation: Hum Pathol. 2004 Jun;35(6):675-84
references.pmid: 15188133
references.citation: Gastrointest Endosc. 2006 Jun;63(7):894-909
references.pmid: 16733101
references.citation: Endoscopy. 2007 Jul;39(7):616-9
references.pmid: 17611916
references.citation: Gastrointest Endosc. 1998 Sep;48(3):276-82
references.pmid: 9744604
references.citation: Am J Gastroenterol. 2008 Apr;103(4):883-93
references.pmid: 18190651
references.citation: Gastrointest Endosc. 2004 Apr;59(4):482-6
references.pmid: 15044882
references.citation: Arch Pathol Lab Med. 2006 Jan;130(1):101-6
references.pmid: 16390223
references.citation: Dis Colon Rectum. 1994 Mar;37(3):229-33; discussion 233-4
references.pmid: 8137669
references.citation: Aliment Pharmacol Ther. 2010 Jul;32(2):171-81
references.pmid: 20384609
references.citation: Aliment Pharmacol Ther. 2006 Dec;24(11-12):1631-42
references.pmid: 17094774
references.citation: Aliment Pharmacol Ther. 2009 Jan;29(1):15-28
references.pmid: 18729847
references.citation: Gastrointest Endosc. 2008 Jun;67(7):1091-6
references.pmid: 18513551
references.citation: Gastrointest Endosc. 2005 Mar;61(3):378-84
references.pmid: 15758907
references.citation: Aliment Pharmacol Ther. 2007 Feb 15;25(4):373-84
references.pmid: 17269992
references.citation: Am J Gastroenterol. 2010 Jun;105(6):1319-26
references.pmid: 20485282
references.citation: Korean J Gastroenterol. 2010 Nov;56(5):299-306
references.pmid: 21099237
references.citation: Gastrointest Endosc. 2009 Mar;69(3 Pt 2):700-6
references.pmid: 19251013
references.citation: Can J Gastroenterol. 2009 Mar;23(3):210-4
references.pmid: 19319385