title: Cyclotron Production of (99m)Tc using (100)Mo2C targets.
abstract: An investigative study of the (100)Mo (p,2n)(99m)Tc reaction on a medical cyclotron using (100)Mo2C is reported. This is the first report of this compound being used as a target for this reaction. (100)Mo2C, a refractory carbide with high thermal conductivity, properties which underscore its use on a cyclotron, was synthesized using (100)MoO3. Its ease of oxidation back to (100)MoO3 under air at elevated temperatures facilitates the use of thermo-chromatography, a high temperature gas phase separation technique for the separation and isolation of (99m)Tc. Activity yields for (99m)Tc averaged 84% of the calculated theoretical yields. Additionally, the percent recovery of MoO3, the precursor for Mo2C, was consistently high at 85% ensuring a good life cycle for this target material. The produced (99m)Tc was radio-chemically pure and easily labeled MDP for imaging purposes.
authors.affiliation: Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
authors.forename: Vernal N
authors.initials: VN
authors.lastname: Richards
authors.forename: Efrem
authors.initials: E
authors.lastname: Mebrahtu
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Lapi
mesh_terms: D000818:Animals; D017357:Cyclotrons; D007554:Isotopes / Q000737:chemistry; D051379:Mice; D008982:Molybdenum / Q000737:chemistry*; D011854:Radiochemistry / Q000295:instrumentation*; D013667:Technetium / Q000737:chemistry*; D013669:Technetium Tc 99m Medronate / Q000737:chemistry; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007554:Isotopes; C574181:molybdenum carbide; D013667:Technetium; D008982:Molybdenum; D013669:Technetium Tc 99m Medronate
keywords: (99m)Tc; Cyclotron; Mo(2)C; Thermochromatography