title: Systems medicine: helping us understand the complexity of disease.
abstract: Advances in genomics and other -omic fields in the last decade have resulted in unprecedented volumes of complex data now being available. These data can enable physicians to provide their patients with care that is more personalized, predictive, preventive and participatory. The expertise required to manage and understand this data is to be found in fields outside of medical science, thus multidisciplinary collaboration coupled to a systems approach is key to unlocking its potential, with concomitant new ways of working. Systems medicine can build on the successes in the field of systems biology, recognizing the human body as the multidimensional network of networks that it is. While systems medicine can provide a conceptual and theoretical framework, its practical goal is to provide physicians the tools necessary for harnessing the rapid advances in basic biomedical science into their routine clinical arsenal.
authors.affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. drieke.vandamme@ucd.ie.
authors.forename: D
authors.initials: D
authors.lastname: Vandamme
authors.forename: W
authors.initials: W
authors.lastname: Fitzmaurice
authors.forename: B
authors.initials: B
authors.lastname: Kholodenko
authors.forename: W
authors.initials: W
authors.lastname: Kolch
mesh_terms: D015510:Clinical Medicine / Q000639:trends*; D019468:Disease Management; D023281:Genomics / Q000379:methods*; D006801:Humans; D057285:Precision Medicine / Q000639:trends; D011315:Preventive Medicine; D012106:Research; D049490:Systems Biology / Q000379:methods*