title: Anti-oxidant and anti-inflammatory activities of Inonotus obliquus and germinated brown rice extracts.
abstract: Inonotus obliquus (IO) is parasitic mushroom that grows on birch and other trees in Russia, Korea, Europe and United States. However, IO is not readily available for consumption due to its high cost and difficult growth. In this regard, IO was inoculated on germinated brown rice (GBR) in the present study and the antioxidant and anti-inflammatory activities of the IO grown on germinated brown rice (IOGBR) extracts were evaluated extensively and compared with those for IO and GBR. IOGBR showed highest antioxidant activities with scavenging total intracellular ROS and MDA levels as well as increasing the antioxidant enzymes activity in the H₂O₂-stimulated mice liver. It also exhibited best inflammatory activities by suppressing the proinflammatory mediators such as NO, PGE₂, iNOS, COX-2, TNF-α, IL-1β, and IL-6 in an LPS-stimulated RAW 264.7 cell line. This study provides a comparative approach to find out an excellent natural source of antioxidants and anti-inflammatory agent as a dietary supplement.
authors.affiliation: Department of Life Science, College of Biomedical and Health Science, Research Institute of Inflammatory Disease, Konkuk University, Chungju 380-701, Korea.
authors.forename: Trishna
authors.initials: T
authors.lastname: Debnath
authors.forename: Sa Ra
authors.initials: SR
authors.lastname: Park
authors.forename: Da Hye
authors.initials: DH
authors.lastname: Kim
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Jo
authors.forename: Beong Ou
authors.initials: BO
authors.lastname: Lim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry / Q000254:growth & development; D019587:Dietary Supplements; D018525:Germination / Q000502:physiology; D006861:Hydrogen Peroxide / Q000633:toxicity; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D012275:Oryza / Q000737:chemistry* / Q000254:growth & development; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D008070:Lipopolysaccharides; D010936:Plant Extracts; D006861:Hydrogen Peroxide
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