title: Apolipoprotein A1 as a potential biomarker in the ascitic fluid for the differentiation of advanced ovarian cancers.
abstract: BACKGROUND
  Primary ovarian cancer and ovarian metastasis from non-ovarian cancers in advanced stage are closely mimicking conditions whose therapeutics and prognosis are different.
  
  
  OBJECTIVE
  To identify biomarkers that can differentiate the two variants of advanced ovarian cancers.
  
  
  METHODS
  Gel-based proteomics and antibody-based assays were used to study the differentially expressed proteins in the ascitic fluid of fourteen patients with advanced ovarian cancers.
  
  
  RESULTS
  Programmed Cell Death 1-Ligand 2, apolipoprotein A1, apolipoprotein A4 and anti-human fas antibody are differentially expressed proteins.
  
  
  CONCLUSIONS
  Apolipoprotein A1 with a 61.8 ng/ml cut-off is a potential biomarker with the best differentiating statistical parameters.
authors.affiliation: Department of Biophysics, All India Institute of Medical Sciences , Ansari nagar, New Delhi, 110029 , India.
authors.forename: Gururao
authors.initials: G
authors.lastname: Hariprasad
authors.forename: Roopa
authors.initials: R
authors.lastname: Hariprasad
authors.forename: Lalit
authors.initials: L
authors.lastname: Kumar
authors.forename: Alagiri
authors.initials: A
authors.lastname: Srinivasan
authors.forename: Srujana
authors.initials: S
authors.lastname: Kola
authors.forename: Amit
authors.initials: A
authors.lastname: Kaushik
mesh_terms: D016632:Apolipoprotein A-I / Q000378:metabolism*; D001202:Ascitic Fluid / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D040901:Proteomics
chemical_list: D016632:Apolipoprotein A-I; D014408:Biomarkers, Tumor