title: Antibacterial activity and cytocompatibility of Cu-Ti-O nanotubes.
abstract: TiO2 nanotubes (NTs) have favorable biological properties, but the poor antibacterial activity limits their application especially in orthopedics fields. In this article, Cu-Ti-O nanotubes with different Cu contents are fabricated on sputtered TiCu films. Scanning electron microscopy reveals the NTs can be formed on sputtered TiCu films when the Cu content is less than 14.6 at %. X-ray photoelectron spectroscopy results indicate the NTs are consist of CuO mixed with TiO2 and the Cu content in NTs decreases dramatically compared with that in TiCu films. Biological experiments show that although these NTs have poor release antibacterial activity, their contact antibacterial activity has proven to be excellent, indicating the NT surface can effectively inhibit biomaterial-associated infections. The cytocompatibility of the NTs is closely related to the Cu content and when its content is relatively low (1.01 at %), there is no appreciable cytotoxicity. So Cu-Ti-O NTs with 1 at % Cu may be suitable to achieve proper antibacterial activity and desired cytocompatibility. The Cu-Ti-O NTs integrate the favorable antibacterial activity of Cu and excellent biological properties of TiO2 NTs therefore have potential applications in orthopedics, dentistry, and other biomedical fields.
authors.affiliation: Research Institute of Surface Engineering, Taiyuan University of Technology, 030024, Taiyuan, China.
authors.forename: Ruiqiang
authors.initials: R
authors.lastname: Hang
authors.forename: Ang
authors.initials: A
authors.lastname: Gao
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Huang
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Wang
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Qin
authors.forename: Bin
authors.initials: B
authors.lastname: Tang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000517:prevention & control; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry* / Q000494:pharmacology; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D010087:Oxides; D003300:Copper; D014025:Titanium
keywords: Cu-Ti-O nanotubes; antibacterial activity; cytocompatibility