title: First total synthesis of the proposed structure of batatin VI.
abstract: The first total synthesis of batatin VI, an architecturally novel resin glycoside dimer, has been achieved via a convergent [5 + 3] glycosidic coupling approach. An improved protocol for the construction of the key 18-membered macrolactone core using a Keck macrolactonization method was introduced. However, the synthesized compound was not identical to the natural batatin VI.
authors.affiliation: Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, Department of Chemistry of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: San-Yong
authors.initials: SY
authors.lastname: Zhu
authors.forename: Jia-Sheng
authors.initials: JS
authors.lastname: Huang
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Zheng
authors.forename: Kai
authors.initials: K
authors.lastname: Zhu
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Yang
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D012116:Resins, Plant / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D018942:Macrolides; D009844:Oligosaccharides; D012116:Resins, Plant; C585753:batatin VI