title: [Correlation between MCP-1, HbA1c and glomerular filtration in nondiabetic patients].
abstract: OBJECTIVE
  This study aims investigate if nondiabetic subjects with fasting glucose < 126 mg/dL but altered HbA1c already have lower estimated glomerular filtration (eGFR) and high serum MCP-1 levels in comparison to nondiabetics with normal HbA1c, independent of other metabolic changes.
  
  
  METHODS
  Data were derived from the database of the CAMELIA (cardio-metabolic-renal family) study, a cross sectional study performed between July 2006 and December 2007, with participants recruited from the Family Doctor Program, Niterói, RJ.
  
  
  RESULTS
  An independent association between changes in HbA1c (≥ 5.7 and < 6.5% versus < 5.7%) and decreased eGFR rate was found. The HbA1c was shown to be a marker of metabolic changes in nondiabetic subjects with fasting glucose < 126 mg/dL, particularly in women and blacks.
  
  
  CONCLUSIONS
  These observations support the use of HbA1c levels in strategies for early intervention and prevention of chronic diseases such as diabetes mellitus and chronic kidney disease.
authors.affiliation: Universidade Federal do Rio de Janeiro, Macaé, Faculdade de Medicina, Macaé, RJ, Brasil.
authors.forename: Verônica Alcoforado de
authors.initials: VA
authors.lastname: Miranda
authors.forename: Maria Luiza Garcia
authors.initials: ML
authors.lastname: Rosa
authors.forename: Jocemir Ronaldo
authors.initials: JR
authors.lastname: Lugon
authors.forename: Rubens Antunes
authors.initials: RA
authors.lastname: Cruz Filho
authors.forename: Talita Sposito de
authors.initials: TS
authors.lastname: Oliveira
authors.forename: Adriana Neves Ladeira da
authors.initials: AN
authors.lastname: Silva
authors.forename: Hye Chung
authors.initials: HC
authors.lastname: Kang
authors.forename: Denizar Vianna
authors.initials: DV
authors.lastname: Araújo
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D018932:Chemokine CCL2 / Q000097:blood*; D002648:Child; D003404:Creatinine / Q000032:analysis*; D005215:Fasting / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000652:urine; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D018932:Chemokine CCL2; D003404:Creatinine; D006442:Glycated Hemoglobin; D012964:Sodium; C111835:CCL2 protein, human; C517652:hemoglobin A1c protein, human