title: Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003.
abstract: BACKGROUND
  Case reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system-related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy.
  
  
  METHODS
  Through a case-control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999-2003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy.
  
  
  RESULTS
  Of the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63-1.56 and 2.44; 95% confidence interval, 1.08-5.53 among breech presentation infants. Probabilistic bias analysis supported these findings.
  
  
  CONCLUSIONS
  No association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted.
authors.affiliation: University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Pittsburgh, Pennsylvania; Centers for Disease Control and Prevention, National Center for Injury Research and Control, Division of Unintentional Injury Prevention, Atlanta, Georgia (Currently).
authors.forename: Erin K
authors.initials: EK
authors.lastname: Sauber-Schatz
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Bodnar
authors.forename: Harold B
authors.initials: HB
authors.lastname: Weiss
authors.forename: John W
authors.initials: JW
authors.lastname: Wilson
authors.forename: Mark D
authors.initials: MD
authors.lastname: Pearlman
authors.forename: Nina
authors.initials: N
authors.lastname: Markovic
mesh_terms: D000062:Accidents, Occupational; D000063:Accidents, Traffic; D000328:Adult; D001741:Black or African American; D001946:Breech Presentation / Q000453:epidemiology* / Q000208:ethnology; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D009421:Nervous System Malformations / Q000453:epidemiology* / Q000208:ethnology; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications; D015995:Prevalence; D062486:Public Health Surveillance; D012042:Registries; D012189:Retrospective Studies; D013781:Texas / Q000453:epidemiology; D044465:White People
keywords: Texas; birth defects; central nervous system; injury; pregnancy