title: Plasticization and antiplasticization of an acrylic pressure sensitive adhesive by ibuprofen and their effect on the adhesion properties.
abstract: In transdermal patches, an unpredictable alteration of the mechanical behavior of the pressure sensitive adhesive (PSA) can occur if a drug is added. In the present study, the suitability of Dynamic Mechanical Analysis (DMA)/Dynamic Mechanical Thermal Analysis (DMTA) as methodologies to detect the change in adhesion properties caused by the addition of an API was examined. With DMA/DMTA, time- and temperature-dependent viscoelastic properties were determined. Tack and shear adhesion of blends of the acrylic adhesive DuroTak® 87-4287 and ibuprofen at increasing concentrations were investigated. Interestingly, the probe tack test showed highest values at 1% ibuprofen concentration in the PSA and decreasing values with increasing ibuprofen concentrations. The shear adhesion of the PSA was decreased at all investigated ibuprofen concentrations. With DMA/DMTA, it could be demonstrated that antiplasticization and plasticization are responsible for the change in tack. The main reason for the decrease in shear adhesion is a shift of the Tg to lower temperatures, while antiplasticization only has a marginal effect. The term "antiplasticizing space" was introduced because antiplasticization depends on time, temperature, stress, strain, and API concentration. In general, this antiplasticizing space can have an impact on processing, stability, and in vivo behavior of API/polymer blends in drug formulations.
authors.affiliation: Department of Chemistry, Division of Pharmaceutical Technology, University of Hamburg, Hamburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Michaelis
authors.affiliation: Beiersdorf AG, Analytics Department, Hamburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Brummer
authors.affiliation: Department of Chemistry, Division of Pharmaceutical Technology, University of Hamburg, Hamburg, Germany. Electronic address: Claudia.Leopold@pharmaceutical-technology.de.
authors.forename: C S
authors.initials: CS
authors.lastname: Leopold
mesh_terms: D000269:Adhesives / Q000008:administration & dosage* / Q000737:chemistry*; D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical / Q000379:methods; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry*; D010968:Plasticizers / Q000008:administration & dosage* / Q000737:chemistry*; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry; D011312:Pressure; D013696:Temperature; D057968:Transdermal Patch
chemical_list: D000269:Adhesives; D010968:Plasticizers; D011108:Polymers; D007052:Ibuprofen
keywords: Antiplasticization; Dynamic Mechanical Analysis (DMA); Dynamic Mechanical Thermal Analysis (DMTA); Ibuprofen; Plasticization; Pressure sensitive adhesive (PSA); Shear adhesion; Tack; Transdermal patch