title: A new phenylethanoid glycoside with antioxidant and anti-HBV activity from Tarphochlamys affinis.
abstract: A new phenylethanoid glycoside, named taraffinisoside A (1), together with five known glycosides were isolated from the stems and leaves of Tarphochlamys affinis. The structure of taraffinisoside A was identified on the basis of detailed spectral analysis. Compounds 1-4 and 6 showed potent antioxidant activities with IC50 values of 10.36, 19.73, 43.95, 15.30 and 46.04 μM by 1,1-diphenyl-2-picryhydrazyl radical-scavenging assay. Compounds 1, 2 and 4 showed anti-HBV activities, with IC50 values of 0.50, 0.72 and 0.26 mM for HBsAg and 0.93, 0.42 and 0.07 mM for HBeAg, respectively.
authors.affiliation: Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Xian-Li
authors.initials: XL
authors.lastname: Zhou
authors.forename: Qing-Wei
authors.initials: QW
authors.lastname: Wen
authors.forename: Xing
authors.initials: X
authors.lastname: Lin
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Ying-Xin
authors.initials: YX
authors.lastname: Li
authors.forename: You-Jia
authors.initials: YJ
authors.lastname: Guo
authors.forename: Ren-Bin
authors.initials: RB
authors.lastname: Huang
mesh_terms: D027901:Acanthaceae / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056945:Hep G2 Cells; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006513:Hepatitis B e Antigens / Q000378:metabolism; D006515:Hepatitis B virus / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D015394:Molecular Structure; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves; D018547:Plant Stems; D010946:Plants, Medicinal
chemical_list: D000975:Antioxidants; D000998:Antiviral Agents; D001713:Biphenyl Compounds; D004187:Disaccharides; D006027:Glycosides; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D010851:Picrates; C000594172:taraffinisoside A; C004931:1,1-diphenyl-2-picrylhydrazyl