title: A material-sparing method for assessment of powder deformation characteristics using data collected during a single compression-decompression cycle.
abstract: Compressibility profiles, or functions of solid fraction versus applied pressure, are used to provide insight into the fundamental mechanical behavior of powders during compaction. These functions, collected during compression (in-die) or post ejection (out-of-die), indicate the amount of pressure that a given powder formulation requires to be compressed to a given density or thickness. To take advantage of the benefits offered by both methods, the data collected in-die during a single compression-decompression cycle will be used to generate the equivalent of a complete out-of-die compressibility profile that has been corrected for both elastic and viscoelastic recovery of the powder. This method has been found to be both a precise and accurate means of evaluating out-of-die compressibility for four common tableting excipients. Using this method, a comprehensive characterization of powder compaction behavior, specifically in relation to plastic/brittle, elastic and viscoelastic deformation, can be obtained. Not only is the method computationally simple, but it is also material-sparing. The ability to characterize powder compressibility using this approach can improve productivity and streamline tablet development studies.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania, 15282.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Katz
authors.forename: Rahul
authors.initials: R
authors.lastname: Roopwani
authors.forename: Ira S
authors.initials: IS
authors.lastname: Buckner
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D019245:Compressive Strength; D004339:Drug Compounding / Q000379:methods*; D005079:Excipients / Q000737:chemistry; D011208:Powders / Q000737:chemistry*; D011312:Pressure; D013607:Tablets / Q000737:chemistry
chemical_list: D005079:Excipients; D011208:Powders; D013607:Tablets
keywords: compaction; compression; materials science; mechanical properties; porosity; solid dosage form; tablet; tableting