title: Development of a metal-ion-mediated base pair for electron transfer in DNA.
abstract: A new C-nucleoside structurally based on the hydroxyquinoline ligand was synthesized that is able to form stable pairs in DNA in both the absence and the presence of metal ions. The interactions between the metal centers in adjacent Cu(II)-mediated base pairs in DNA were probed by electron paramagnetic resonance (EPR) spectroscopy. The metal-metal distance falls into the range of previously reported values. Fluorescence studies with a donor-DNA-acceptor system indicate that photoinduced charge-transfer processes across these metal-ion-mediated base pairs in DNA occur more efficiently than over natural base pairs.
authors.affiliation: Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany), Fax: (+49) 721-608-44825.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ehrenschwender
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schmucker
authors.forename: Christian
authors.initials: C
authors.lastname: Wellner
authors.forename: Timo
authors.initials: T
authors.lastname: Augenstein
authors.forename: Patrick
authors.initials: P
authors.lastname: Carl
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Harmer
authors.forename: Frank
authors.initials: F
authors.lastname: Breher
authors.forename: Hans-Achim
authors.initials: HA
authors.lastname: Wagenknecht
mesh_terms: D020029:Base Pairing; D003300:Copper; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D004579:Electron Transport; D004583:Electrons; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*
chemical_list: D006912:Hydroxyquinolines; D008670:Metals; D009705:Nucleosides; D003300:Copper; D004247:DNA
keywords: DNA; copper; donor-acceptor systems; electron transfer; nucleosides