title: Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
abstract: OBJECTIVE
  This genome-wide association study (GWAS) investigated the relationship between molar-incisor hypomineralization (MIH) and possible genetic loci. Clinical and genetic data from the 10-year follow-up of 668 children from the Munich GINI-plus and LISA-plus birth cohort studies were analyzed.
  
  
  METHODS
  The dental examinations included the diagnosis of MIH according to the criteria of the European Academy of Paediatric Dentistry (EAPD). Children with MIH were categorized as those with a minimum of one hypomineralized first permanent molar. A GWAS was implemented following a quality-control step and an additive genetic effect was assumed.
  
  
  RESULTS
  A total of 2,013,491 single-nucleotide polymorphisms (SNPs) were available for analysis. Rs13058467, which is located near the SCUBE1 gene on chromosome 22 (p < 3.72E-7), was identified as a possible locus linked to MIH when using a threshold of p value <1E-6.
  
  
  CONCLUSIONS
  After considering the limitations of the present study (e.g., limited sample size and lack of an independent replication sample), it can be concluded that (1) replication analyses in an independent cohort study are strongly recommended and (2) large-scale and well-powered studies are needed to investigate a possible genetic link to MIH.
authors.affiliation: Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians University of Munich, Goethestraße70, Munich, 80336, Germany, jkuehn@dent.med.uni-muenchen.de.
authors.forename: Jan
authors.initials: J
authors.lastname: Kühnisch
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Thiering
authors.forename: Daniela
authors.initials: D
authors.lastname: Heitmüller
authors.forename: Carla M T
authors.initials: CM
authors.lastname: Tiesler
authors.forename: Harald
authors.initials: H
authors.lastname: Grallert
authors.forename: Roswitha
authors.initials: R
authors.lastname: Heinrich-Weltzien
authors.forename: Reinhard
authors.initials: R
authors.lastname: Hickel
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
mesh_terms: D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003744:Dental Enamel Hypoplasia / Q000235:genetics*; D055106:Genome-Wide Association Study; D005858:Germany; D006801:Humans; D007223:Infant
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