title: On your (methyl) mark, get TET1, go!
abstract: Tet proteins and DNA demethylation are key regulators of embryonic stem cells, but their roles in development and tissue stem cells remain unclear. In this issue, Zhang et al. (2013) show that Tet1 regulates adult hippocampal neurogenesis by controlling progenitor proliferation, and Tet1 deficiency generates defects in learning and memory.
authors.affiliation: Department of Molecular Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Shradha
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Jenny
authors.initials: J
authors.lastname: Hsieh
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D003071:Cognition; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006624:Hippocampus / Q000254:growth & development* / Q000378:metabolism*; D055495:Neurogenesis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C540839:TET1 protein, mouse