title: [Abnormal expressions of positive cell cycle control factors and thyroid carcinoma occurrence and progression].
abstract: OBJECTIVE
  To explore the relationship between abnormal expressions of positive cell cycle control factors and thyroid carcinoma occurrence and progression, and assess the value of these factors in evaluating tumor cell proliferation activity and the prognosis of the patients.
  
  
  METHODS
  Immunohistochemical SP method was used to detect the expressions of MCM7, CDK2 and Ki-67 proteins in 50 cases of thyroid carcinoma, 30 cases of thyroid adenoma, 30 cases of nodular goiter and 20 cases of normal thyroid gland tissues.
  
  
  RESULTS
  The positive rates of MCM7, CDK2 and Ki-67 expressions in thyroid carcinoma were 100% (50/50), 80.00% (40/50) and 84.00% (42/50), significantly higher than the rates in thyroid adenoma, nodular goiter and normal thyroid tissue (P<0.01). In thyroid carcinoma tissues, positive correlations were observed between the expressions of MCM7 and CDK2 proteins (r=0.637, P<0.01), MCM7 and Ki-67 proteins (r=0.633, P<0.01), and CDK2 and Ki-67 proteins (r=0.862, P<0.01).
  
  
  CONCLUSIONS
  The high expressions of MCM7, CDK2 and Ki-67 protein may contribute to the development of thyroid carcinoma, and their combined examination may serve as useful index for early diagnosis and prognostic evaluation of thyroid carcinoma. MCM7 is superior to Ki-67 in the evaluation of the thyroid tumor cell proliferation activity.
authors.affiliation: Department of Pathology, Medical College of Guangxi University of Science and Technology, Liuzhou, China. shilin19811120@163.com
authors.forename: Lin
authors.initials: L
authors.lastname: Shi
authors.forename: Anwen
authors.initials: A
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Luo
authors.forename: Shimei
authors.initials: S
authors.lastname: Zhao
authors.forename: Haiyan
authors.initials: H
authors.lastname: Tian
authors.forename: Yanchu
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D064168:Minichromosome Maintenance Complex Component 7 / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: D019394:Ki-67 Antigen; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2; C101624:MCM7 protein, human; D064168:Minichromosome Maintenance Complex Component 7