title: Dioxin sensitivity-related two critical amino acids of arylhydrocarbon receptor may not correlate with the taxonomy or phylogeny in avian species.
abstract: There are two arylhydrocarbon receptor (AhR) isoforms in birds, AhR1 and AhR2. The varying sensitivity of AhR is reported to be related to two critical amino acids at positions 325 and 381 in the AhR1 ligand-binding domain. In this study, seven avian species whose in vivo dioxin sensitivity was known, and 13 species with no data regarding their in vivo dioxin sensitivity were examined. The two critical amino acids in the ligand-binding domain were investigated in avian species, and the results were compared with the taxonomy or phylogenetic trees for the bird AhR proteins. We found that the two critical amino acids did not correlate with the taxonomy or phylogeny of these proteins, suggesting that dioxin sensitivity was independent of taxonomy.
authors.affiliation: Laboratory of Toxicology, Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Fujisawa
authors.forename: Yusuke K
authors.initials: YK
authors.lastname: Kawai
authors.forename: Shouta M M
authors.initials: SM
authors.lastname: Nakayama
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ikenaka
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ishizuka
mesh_terms: D000596:Amino Acids / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D001717:Birds / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D004147:Dioxins / Q000633:toxicity*; D016013:Likelihood Functions; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010802:Phylogeny; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics* / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D013045:Species Specificity
chemical_list: D000596:Amino Acids; D017931:DNA Primers; D018076:DNA, Complementary; D004147:Dioxins; D018336:Receptors, Aryl Hydrocarbon
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