title: Novel electrospun nanotholits/PHB scaffolds for bone tissue regeneration.
abstract: Nanotholits is an osteoinductor or be, stimulates the bone regeneration, enabling bigger migration of the cells for formation of the bone tissue regeneration mainly because nanotholits are rich in minerals considered essential to the bone mineralization process on a protein matrix (otolin) as hydroxiapatite. In order to improve its biodegrability and bioresorption in new platforms for tissue engineering, it was electrospun PHB/nanotholits from aqueous solutions of this polymer at concentrations of nanotholits 1% (w/v) and compared morphological and thermal properties with PHB/nanotholits casting films. Electrospun PHB/nanotholits mats presents more symmetric nanopore structure than casting films mats observed by SEM images mainly because the orientation of pores along the longitudinal direction of the electrospun fibers. Nanotholits influences in PHB electrospun/casting was analyzed using transmission infrared spectroscopy (FTIR). TGA showed similar thermal properties but DSC showed distinct thermal properties and crystallinity process of the developed bionanocomposite mainly because of different processing.
authors.affiliation: Department of Nanoscience and Advanced Materials-UFABC, Rua Santa Adélia, 166, Santo André-SP 09291-210, Brazil.
authors.forename: Lauro
authors.initials: L
authors.lastname: Xavier Filho
authors.forename: Gabriel Molina
authors.initials: GM
authors.lastname: Olyveira
authors.forename: Pierre
authors.initials: P
authors.lastname: Basmaji
authors.forename: Ligia Maria Manzine
authors.initials: LM
authors.lastname: Costa
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D004563:Electrochemistry / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006801:Humans; D006885:Hydroxybutyrates / Q000737:chemistry*; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D011091:Polyesters / Q000737:chemistry*; D000091402:Prohibitins; D012399:Rotation; D054457:Tissue Scaffolds; D000094122:Polyhydroxybutyrates
chemical_list: D006885:Hydroxybutyrates; D011091:Polyesters; D000091402:Prohibitins; C000717328:PHB protein, human; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates