title: Anorgasmia during pregabalin add-on therapy for partial seizures.
abstract: Anorgasmia is the inability to reach orgasm during sexual intercourse, and, although it is believed that around 90% of anorgasmia problems are related to psychological issues, the use of serotoninergic drugs, including antidepressants and atypical antipsychotics, is a common cause of situational anorgasmia. Pregabalin is a new antiepileptic drug, structurally related to gabapentin, and commonly used as adjunctive therapy for partial epilepsy and treatment of neuropathic pain in adults. Herein, we describe three men with epilepsy, who experienced severe anorgasmia after pregabalin add-on treatment.
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo" Messina, Italy.
authors.forename: Rocco Salvatore
authors.initials: RS
authors.lastname: Calabrò
authors.forename: Rosaria
authors.initials: R
authors.lastname: De Luca
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pollicino
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009948:Orgasm / Q000187:drug effects*; D000069583:Pregabalin; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000150:complications; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid