title: Ovarian pulmonary-type small cell carcinoma: case report and review of the literature.
abstract: Ovarian pulmonary-type small cell carcinoma is a rare and extremely aggressive neoplasm. We report the occurrence of an ovarian small cell carcinoma of pulmonary type in a 54-year-old woman. She underwent a total abdominal hysterectomy with a bilateral salpingo-oophorectomy and infracolic omentectomy. A diagnosis of stage IIIA pulmonary-type small cell carcinoma was rendered. The tumor appeared to be composed of a solid growth of small cells arranged in sheets and closely packed nests with insular arrangements separated by a fibrous stroma. The tumor cells had hyperchromatic nuclei with inconspicuous nucleoli and scanty cytoplasm. Rosette and rosette-like structures were scattered. Immunohistochemical staining showed positivity for synaptophysin, neural cell adhesion molecule (NCAM), and focally for chromogranin. Cytokeratin and neuron-specific enolase (NSE) were also positive. Over 80% of the tumor cells showed strong reactivity for MIB-1. Electron microscopy showed neuroendocrine granules. She was effectively treated with paclitaxel plus carboplatin after the surgery.
authors.affiliation: Department of Obstetrics and Gynecology, Keiyu Hospital, Yokohama City, Japan. sputnik0621@yahoo.co.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Kurasaki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sakurai
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Taoka
authors.forename: Kei
authors.initials: K
authors.lastname: Takahashi
authors.forename: Kaneyuki
authors.initials: K
authors.lastname: Kubushiro
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use; D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000077216:Carcinoma, Ovarian Epithelial; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002352:Carrier Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008168:Lung / Q000473:pathology; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D017239:Paclitaxel / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D002352:Carrier Proteins; C533270:NSMCE1 protein, human; D019006:Neural Cell Adhesion Molecules; D007633:Keratins; D016190:Carboplatin; C513496:MIB1 ligase, human; D044767:Ubiquitin-Protein Ligases; D017239:Paclitaxel