title: Clinical significance of serum CA-125 in Korean females with ascites.
abstract: OBJECTIVE
  Mycobacterium tuberculosis is endemic in Korea. Because tuberculous peritonitis is characterized by ascites, abdominal pain, abdominal mass and elevation of serum CA-125, it can be confused with ovarian malignancies. The aim of this study was to evaluate the significance of serum CA-125 level in the differential diagnosis of tuberculous peritonitis and ovarian malignancy in a Mycobacterium tuberculosis-endemic area.
  
  
  METHODS
  The medical records of patients diagnosed with tuberculous peritonitis (n=48) or epithelial ovarian malignancy (n=370) at Samsung Medical Center from January 2000 to October 2009 were retrospectively reviewed.
  
  
  RESULTS
  Median serum CA-125 level in the epithelial ovarian cancer group was significantly higher than that in the tuberculous peritonitis group (p ≤ 0.01). Only one patient (2.1%) in the tuberculous peritonitis group had a serum CA-125 level over 2000 U/mL. However, 109 patients (29.5%) in the epithelial ovarian cancer group had a serum CA-125 level over 2000 U/mL. At the CA-125 ranges of 400 to 599 and 600 to 799, the proportions of those with tuberculous peritonitis were 24% and 21.9%, respectively. At a serum CA-125 level over 1000 U/mL, however, the proportion of tuberculous peritonitis was much lower (2.1%).
  
  
  CONCLUSIONS
  Tuberculous peritonitis should be considered in the evaluation of female patients with ascites and high serum CA-125.
authors.affiliation: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Bae
authors.forename: Jun Haeng
authors.initials: JH
authors.lastname: Lee
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Park
authors.forename: Da-min
authors.initials: DM
authors.lastname: Kim
authors.forename: Byung-Hoon
authors.initials: BH
authors.lastname: Min
authors.forename: Poong-Lyul
authors.initials: PL
authors.lastname: Rhee
authors.forename: Jae J
authors.initials: JJ
authors.lastname: Kim
mesh_terms: D001201:Ascites / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015999:Multivariate Analysis; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis*; D014395:Peritonitis, Tuberculous / Q000097:blood / Q000175:diagnosis*; D056910:Republic of Korea; D012189:Retrospective Studies
chemical_list: D018394:CA-125 Antigen
keywords: Ascites; epithelial ovarian cancer; serum CA-125; tuberculous peritonitis
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