title: Pre-diagnosis cigarette smoking and overall survival in non-Hodgkin lymphoma.
abstract: We examined whether smoking prior to non-Hodgkin lymphoma (NHL) diagnosis was associated with overall survival (OS) and conducted a meta-analysis to assess the evidence relating pre-diagnosis cigarette smoking with OS. Among 523 NHL patients, worse OS was suggested for greater pre-diagnostic smoking habits when compared to never smokers. In the meta-analysis (n = 5 patient populations), inferior OS was observed for greater number of cigarettes smoked per day, years of cigarette smoking, and pack-years of cigarette smoking. The inferior survival was more pronounced for follicular than for diffuse large B cell lymphoma. Pre-diagnosis cigarette smoking may adversely impact the survival of NHL patients.
authors.affiliation: Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Health Studies, University of Chicago, Chicago, IL, USA.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Ollberding
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Evens
authors.forename: Briseis
authors.initials: B
authors.lastname: Aschebrook-Kilfoy
authors.forename: Donne Bennett D
authors.initials: DB
authors.lastname: Caces
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Weisenburger
authors.forename: Sonali M
authors.initials: SM
authors.lastname: Smith
authors.forename: Brian C-H
authors.initials: BC
authors.lastname: Chiu
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology*; D016019:Survival Analysis
keywords: cigarettes; meta-analysis; non-Hodgkin lymphoma; pooled analysis; smoking
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