title: Use of OMIC technologies to study arsenic exposure in human populations.
abstract: Exposure to arsenic (As) in drinking water is a major health concern. More than 100 million individuals are exposed to levels over the current World Health Organization standard of 10 µg/L worldwide. Arsenic is one of the few agents established as a human carcinogen prior to understanding its mechanism of carcinogenicity. OMIC technologies have enabled researchers to utilize agnostic approaches to explore new, unknown mechanisms through which As causes disease in exposed human populations. In this article, we present recent studies in which OMIC technologies have been used to explore differences in human biological samples to identify markers of exposure, disease susceptibility, and effect in As-exposed and/or diseased tissues.
authors.affiliation: Division of Cancer Epidemiology and Genetics (DCEG), US National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. moorele@mail.nih.gov
authors.forename: Lee E
authors.initials: LE
authors.lastname: Moore
authors.forename: Sara
authors.initials: S
authors.lastname: Karami
authors.forename: Craig
authors.initials: C
authors.lastname: Steinmaus
authors.forename: Kenneth P
authors.initials: KP
authors.lastname: Cantor
mesh_terms: D001151:Arsenic / Q000633:toxicity*; D004781:Environmental Exposure; D023281:Genomics; D006801:Humans; D055432:Metabolomics; D040901:Proteomics; D059467:Transcriptome
chemical_list: D001151:Arsenic
keywords: OMICS; arsenic; epigenetics; transciptonics proteomics