title: Endoscopic full-thickness resection of colonic submucosal tumors originating from the muscularis propria: an evolving therapeutic strategy.
abstract: Endoscopic resection of colonic submucosal tumors (SMTs) is challenging and carries a high risk of perforation. In this prospective pilot study we aimed to evaluate the feasibility, safety, and efficacy of endoscopic full-thickness resection of colonic SMTs. The study enrolled 19 consecutive patients with colonic SMTs 3 cm in size or smaller. In 18 of the 19 patients full-thickness resection was carried out endoscopically with the entire tumor capsule intact. In 16 of these18 patients, full-thickness resection was carried out and the colonic wall defect closed all endoscopically; in the other 2 patients, laparoscopic closure was needed. Two cases of local peritonitis were managed with conservative treatment. No deaths occurred within 30 days, and no recurrence was detected after a median of 18 months' follow-up. Endoscopic full-thickness resection is a novel method enabling resection of colonic SMTs. The colonic wall mucosal defect can be closed endoscopically in the majority of cases. It appears to be a safe and effective endoscopic technique for managing these tumors, which traditionally are managed by colonic resection.
authors.affiliation: Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Meidong
authors.initials: M
authors.lastname: Xu
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Wang
authors.forename: Ping-Hong
authors.initials: PH
authors.lastname: Zhou
authors.forename: Quan-Lin
authors.initials: QL
authors.lastname: Li
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yunshi
authors.initials: Y
authors.lastname: Zhong
authors.forename: Weifeng
authors.initials: W
authors.lastname: Chen
authors.forename: Lili
authors.initials: L
authors.lastname: Ma
authors.forename: S
authors.initials: S
authors.lastname: Ishaq
authors.forename: Wenzheng
authors.initials: W
authors.lastname: Qin
authors.forename: Jianwei
authors.initials: J
authors.lastname: Hu
authors.forename: Liqing
authors.initials: L
authors.lastname: Yao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000601:surgery*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000209:etiology*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000209:etiology*; D058106:Wound Closure Techniques