title: mpMoRFsDB: a database of molecular recognition features in membrane proteins.
abstract: CONCLUSIONS
  Molecular recognition features (MoRFs) are small, intrinsically disordered regions in proteins that undergo a disorder-to-order transition on binding to their partners. MoRFs are involved in protein-protein interactions and may function as the initial step in molecular recognition. The aim of this work was to collect, organize and store all membrane proteins that contain MoRFs. Membrane proteins constitute ∼30% of fully sequenced proteomes and are responsible for a wide variety of cellular functions. MoRFs were classified according to their secondary structure, after interacting with their partners. We identified MoRFs in transmembrane and peripheral membrane proteins. The position of transmembrane protein MoRFs was determined in relation to a protein's topology. All information was stored in a publicly available mySQL database with a user-friendly web interface. A Jmol applet is integrated for visualization of the structures. mpMoRFsDB provides valuable information related to disorder-based protein-protein interactions in membrane proteins.
  
  
  BACKGROUND
  http://bioinformatics.biol.uoa.gr/mpMoRFsDB
authors.affiliation: Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis, Athens 157 01, Greece.
authors.forename: Foivos
authors.initials: F
authors.lastname: Gypas
authors.forename: Georgios N
authors.initials: GN
authors.lastname: Tsaousis
authors.forename: Stavros J
authors.initials: SJ
authors.lastname: Hamodrakas
mesh_terms: D030541:Databases, Genetic; D020407:Internet; D008565:Membrane Proteins / Q000032:analysis* / Q000737:chemistry; D012984:Software
chemical_list: D008565:Membrane Proteins