title: Risk factors for midterm cardiac function deterioration after valve replacement surgery in patients with rheumatic mitral stenosis.
abstract: BACKGROUND
  A symptomatic reduction in left ventricular ejection fraction (LVEF) is the main reason for postoperative heart failure after valve replacement surgery. However, postoperative heart failure occurs in patients with normal preoperative LVEF. Therefore, we examined clinical and echocardiographic data of patients with rheumatic heart disease to determine additional risk factors for low LVEF in the postoperative period.
  
  
  RESULTS
  Ninety-seven patients with rheumatic heart disease (RHD) who underwent mitral valve replacement for severe mitral valve stenosis were included retrospectively in this study. All patients had normal LVEF before surgery. Patients were divided into 2 groups based on postoperative LVEF 6 months after surgery. Groups A had normal postoperative LVEF (82 cases, 84.5%), and group B had low postoperative LVEF (15 cases, 15.5%). Clinical and electrocardiographic data were collected to determine risk factors for deterioration in cardiac function. Multivariate analysis revealed that preoperative low systolic peak velocities at the lateral tricuspid annulus (St) and no or mild aortic stenosis were independent risk factors for cardiac deterioration in patients with normal preoperative LVEF. Individuals with preoperative St ≤ 4.8 cm/s were more likely to develop lower LVEF at follow-up (χ(2) = 7.54; P = .006; odds ratio 5.03, 95% confidence interval 1.31-20.82). All 15 patients who had normal preoperative LVEF but abnormal postoperative LVEF had no or only mild aortic valve stenosis.
  
  
  CONCLUSIONS
  Decreased right ventricular function and no or mild aortic stenosis were independent risk factors for low LVEF at follow-up in patients with RHD who had normal preoperative LVEF. The velocity of the tricuspid valve ring should be included in preoperative evaluations to improve the accuracy of postsurgical prognosis and clinical decision making.
authors.affiliation: Cardiovascular Institute and Shenyang Northern Hospital, Shenyang City, China. jinyan4158@vip.sina.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Hui Shan
authors.initials: HS
authors.lastname: Wang
authors.forename: Zeng Wei
authors.initials: ZW
authors.lastname: Wang
authors.forename: Xin Min
authors.initials: XM
authors.lastname: Li
authors.forename: Zong Tao
authors.initials: ZT
authors.lastname: Yin
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000639:trends; D006801:Humans; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D012214:Rheumatic Heart Disease / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery*; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis / Q000503:physiopathology
keywords: Rheumatic heart disease; right ventricular function; valve replacement