title: Effect of statin pretreatment on myocardial perfusion in patients undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis.
abstract: BACKGROUND
  To achieve sufficient myocardial perfusion in ST-segment elevation myocardial infarction (STEMI) patients receiving primary percutaneous coronary intervention (PPCI), many adjunctive therapies have been proposed. Previous trials have reported variances in myocardial perfusion improvement for statin pretreatment, which made it inconvincible to confirm the beneficial effects of statins. Therefore, we performed a systematic review and meta-analysis to determine whether statin pretreatment was effective in improving myocardial perfusion.
  
  
  OBJECTIVE
  Statin pretreatment could improve myocardial perfusion in STEMI patients undergoing PPCI.
  
  
  METHODS
  We searched the PubMed, Web of Knowledge, and the Cochrane Library databases for studies evaluating the impact of statin pretreatment on myocardial perfusion in STEMI patients receiving PPCI.
  
  
  RESULTS
  Twelve trials were finally included in our meta-analysis. There were no significant differences in patients' baseline characteristics between the statin pretreatment and control groups. Overall pooled analysis showed that patients in the statin pretreatment groups had significantly better epicardial coronary blood flow (measured by Thrombosis in Myocardial Infarction [TIMI] grade, odds ratio [OR]: 0.49, 95% confidence interval [CI]: 0.28 to 0.84; measured by corrected TIMI frame count, mean difference: -5.63; 95% CI: -9.66 to -1.6). A trend toward myocardial tissue level perfusion improvement was seen in the statin pretreatment arm rather than the control arm (measured by myocardial blush grade, OR: 0.74; 95% CI: 0.50 to 1.09).
  
  
  CONCLUSIONS
  This present meta-analysis suggests that statin pretreatment might be effective in improving myocardial perfusion in STEMI patients.
authors.affiliation: Department of Cardiology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lyu
authors.forename: Yichao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Tuo
authors.initials: T
authors.lastname: Zhang
authors.forename: Wen
authors.initials: W
authors.lastname: Zhou
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Ancai
authors.initials: A
authors.lastname: Yuan
authors.forename: Tianbao
authors.initials: T
authors.lastname: Yao
authors.forename: Jun
authors.initials: J
authors.lastname: Pu
authors.forename: Ben
authors.initials: B
authors.lastname: He
mesh_terms: D003326:Coronary Circulation / Q000187:drug effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D011300:Preoperative Care / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
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