title: Biogenic gold nanoparticles as fotillas to fire berberine hydrochloride using folic acid as molecular road map.
abstract: Use of biologically modified gold nanoparticles (GNPs) as molecular vehicle to ferry potential anti-cancer drug berberine hydrochloride (BHC) using folic acid (FA) as targeting molecule is reported in this work. A tropical fruit peel, Trapa bispinosa is used to fabricate highly monodispersed GNPs, passivated with essential functional groups which were used as linkers to attach FA and BHC via amide linkage. Flocculation Parameter (FP) of biologically synthesized GNPs was calculated under different salt concentrations which were found to be very ideal under a physiological condition. Various statistical models were used to find drug release profile out of which Higuchi was found to be the most ideal. GNP-FA-BHC complexes were found to be active against folic acid expressing HeLa cells.
authors.affiliation: N. S. N. Research Centre for Nanotechnology and Bionanotechnology, Jambhul Phata, Ambernath (W), 421 505, Maharashtra, India. gurus.spandey@gmail.com
authors.forename: Sunil
authors.initials: S
authors.lastname: Pandey
authors.forename: Ashmi
authors.initials: A
authors.lastname: Mewada
authors.forename: Mukeshchand
authors.initials: M
authors.lastname: Thakur
authors.forename: Ritu
authors.initials: R
authors.lastname: Shah
authors.forename: Goldie
authors.initials: G
authors.lastname: Oza
authors.forename: Madhuri
authors.initials: M
authors.lastname: Sharon
mesh_terms: D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002522:Chlorocebus aethiops; D005427:Flocculation / Q000187:drug effects; D005492:Folic Acid / Q000494:pharmacology*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007700:Kinetics; D029561:Lythraceae / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013818:Thermogravimetry; D014709:Vero Cells
chemical_list: D010936:Plant Extracts; D001599:Berberine; D006046:Gold; D005492:Folic Acid
keywords: Berberine; Drug delivery; Drug release; Folic acid; Nanoparticle; Targeting