title: Second harmonic microscopic imaging and spectroscopic characterization in prostate pathological tissue.
abstract: Second harmonic microscopic imaging and spectroscopy technology has become a powerful tool for biomedical studies, especially in cancer research. In this paper, second harmonic generation in benign prostatic hyperplasia (BPH) and prostate cancer (PC) tissues in mouse model (C57BL6) have been reported. Excitated samples with different wavelength near-infrared laser from 780 to 850 nm we found that second harmonic signals from BPH nuclei stronger than that from PC, and a wavelength sensitivity was also observed in this experiment. Providing useful help for prostate malignancy diagnosis and identifying tissue components on clinic.
authors.affiliation: Laboratory of Photonic Information Technology, South China Normal University, Guangzhou, Guangdong, China.
authors.forename: Yanyue
authors.initials: Y
authors.lastname: Huang
authors.forename: Zhengfei
authors.initials: Z
authors.lastname: Zhuang
mesh_terms: D000818:Animals; D003955:Diagnostic Tests, Routine / Q000379:methods; D004195:Disease Models, Animal; D006965:Hyperplasia / Q000473:pathology*; D008297:Male; D008810:Mice, Inbred C57BL; D008853:Microscopy / Q000379:methods*; D061848:Optical Imaging / Q000379:methods*; D010340:Pathology, Surgical / Q000379:methods; D011467:Prostate / Q000737:chemistry* / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D013057:Spectrum Analysis / Q000379:methods*
keywords: prostate cancer; prostatic hyperplasia; second harmonic generation; wavelength sensitivity