title: Successful treatment of infliximab-associated immune-mediated sensory polyradiculopathy with intravenous immunoglobulin.
abstract: Infliximab, a tumor necrosis factor-alpha antagonist, is used to treat many inflammatory diseases. Various forms of demyelinating neuropathies have been reported as neurological complications associated with infliximab use. There have been few reports of pure sensory neuropathy associated with infliximab. We report the clinical, electrophysiological, and pathological findings of a patient with subacute sensory polyradiculopathy 1 month after infliximab therapy for psoriasis vulgaris. Immune-mediated pathogenesis was suggested by positive anti-ganglioside antibodies and rapid response to intravenous immunoglobulin. This is the first reported case of sensory polyradiculopathy with positive anti-ganglioside antibodies following infliximab therapy. Our findings suggest the clinical importance of immunological investigations and treatment in demyelinating neuropathies following infliximab therapy.
authors.affiliation: Department of Neurology, Tokyo Teishin Hospital, 2-14-23, Fujimi, Chiyoda-ku, Tokyo 102-8798, Japan. Electronic address: hinaruse-tky@umin.ac.jp.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Naruse
authors.forename: Yu
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Risa
authors.initials: R
authors.lastname: Maekawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Etoh
authors.forename: Ayumi
authors.initials: A
authors.lastname: Hida
authors.forename: Jun
authors.initials: J
authors.lastname: Shimizu
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Kaida
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shiio
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D011128:Polyradiculopathy / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D011565:Psoriasis / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D016756:Immunoglobulins, Intravenous; D000069285:Infliximab
keywords: Anti-ganglioside antibodies; IVIg; Infliximab; Intravenous immunoglobulin; Sensory polyradiculopathy; Tumor necrosis factor-alpha antagonist