title: Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?
abstract: The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated with increased serum soluble CEACAM1. In conclusion our data demonstrate increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis in VLBW-infants, and increased circulating soluble CEACAM1 in children with meningococcal sepsis. Increased T-cell CEACAM1 expression and increased circulating soluble CEACAM1 may contribute to sepsis-associated immune suppression.
authors.affiliation: Department of Pediatric Infectious Diseases and Immunology, Erasmus MC - Sophia, Rotterdam, The Netherlands. m.flier@cukz.umcn.nl
authors.forename: Michiel
authors.initials: M
authors.lastname: van der Flier
authors.forename: Dyana B
authors.initials: DB
authors.lastname: Sharma
authors.forename: Silvia
authors.initials: S
authors.lastname: Estevão
authors.forename: Marieke
authors.initials: M
authors.lastname: Emonts
authors.forename: Denise
authors.initials: D
authors.lastname: Rook
authors.forename: Jan A
authors.initials: JA
authors.lastname: Hazelzet
authors.forename: Johannes B
authors.initials: JB
authors.lastname: van Goudoever
authors.forename: Nico G
authors.initials: NG
authors.lastname: Hartwig
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D007230:Infant, Low Birth Weight / Q000097:blood / Q000276:immunology; D007231:Infant, Newborn; D008297:Male; D008589:Meningococcal Infections / Q000150:complications*; D018805:Sepsis / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000378:metabolism*; D012995:Solubility
chemical_list: D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules
references.citation: J Immunol. 2010 Feb 1;184(3):1401-9
references.pmid: 20026737
references.citation: Nat Rev Immunol. 2006 Jun;6(6):433-46
references.pmid: 16724098
references.citation: J Immunol. 2004 Mar 15;172(6):3544-52
references.pmid: 15004155
references.citation: Clin Exp Immunol. 1979 Oct;38(1):9-15
references.pmid: 118835
references.citation: Crit Care. 2012 Jun 28;16(3):R112
references.pmid: 22742734
references.citation: Am J Respir Crit Care Med. 2003 Mar 1;167(5):695-701
references.pmid: 12433670
references.citation: J Hosp Infect. 2005 Dec;61(4):300-11
references.pmid: 16221510
references.citation: Nat Rev Immunol. 2008 Oct;8(10):776-87
references.pmid: 18802444
references.citation: Nat Rev Immunol. 2001 Dec;1(3):220-8
references.pmid: 11905831
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1751-9
references.pmid: 17234957
references.citation: JAMA. 2011 Dec 21;306(23):2594-605
references.pmid: 22187279
references.citation: Eur J Immunol. 2005 Jun;35(6):1949-59
references.pmid: 15909305
references.citation: Nat Immunol. 2002 Mar;3(3):229-36
references.pmid: 11850628
references.citation: J Biol Chem. 2006 Dec 22;281(51):39179-93
references.pmid: 17071610
references.citation: Am J Respir Crit Care Med. 2008 Feb 1;177(3):301-8
references.pmid: 17989345
references.citation: Infect Immun. 2009 Nov;77(11):5170-80
references.pmid: 19720754
references.citation: Eur J Immunol. 2000 Sep;30(9):2593-603
references.pmid: 11009093
references.citation: J Immunol. 2010 Apr 1;184(7):3768-79
references.pmid: 20200277
references.citation: Crit Care Med. 2003 Jun;31(6):1839-47
references.pmid: 12794428
references.citation: Eur J Immunol. 2004 Aug;34(8):2138-48
references.pmid: 15259011
references.citation: J Immunol. 1999 Aug 1;163(3):1363-70
references.pmid: 10415036
references.citation: Science. 2000 Oct 6;290(5489):84-9
references.pmid: 11021804
references.citation: PLoS Pathog. 2012;8(4):e1002597
references.pmid: 22496641
references.citation: Pediatr Crit Care Med. 2005 Jan;6(1):2-8
references.pmid: 15636651
references.citation: Nat Immunol. 2008 Nov;9(11):1270-8
references.pmid: 18836450
references.citation: J Infect Dis. 2001 Jan 1;183(1):149-53
references.pmid: 11106541
references.citation: Ann N Y Acad Sci. 2006 Aug;1072:155-75
references.pmid: 17057197