title: Catechins and antitumor immunity: Not MDSC's cup of tea.
abstract: Numerous laboratory and clinical studies have reported that the green tea catechin extract Polyphenon E exert anticancer activity, but the underlying mechanism of action was elusive. We have recently shown that Polyphenon E exerts antineoplastic effects by antagonizing tumor-induced myeloid derived suppressor cells (MDSCs).
authors.affiliation: Molecular Immunology Unit; UCL Institute of Child Health; London, UK.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Santilli
authors.forename: John
authors.initials: J
authors.lastname: Anderson
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Thrasher
authors.forename: Arturo
authors.initials: A
authors.lastname: Sala
keywords: MDSC; Tregs; mouse models; neuroblastoma; polyphenol
references.citation: Clin Cancer Res. 2013 Mar 1;19(5):1116-25
references.pmid: 23322899
references.citation: Cancer Res. 2007 Jan 15;67(2):802-11
references.pmid: 17234792
references.citation: Fetal Pediatr Pathol. 2013 Jul;32(4):298-307
references.pmid: 23438791
references.citation: Int J Cancer. 2010 Sep 1;127(5):1141-50
references.pmid: 20039320
references.citation: Carcinogenesis. 2013 May;34(5):1081-8
references.pmid: 23349014
references.citation: Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(3):66-80
references.pmid: 21422740
references.citation: J Clin Oncol. 2012 Oct 1;30(28):3525-32
references.pmid: 22927533
references.citation: N Engl J Med. 2010 Sep 30;363(14):1324-34
references.pmid: 20879881
references.citation: Cancer Immunol Immunother. 2007 Sep;56(9):1443-58
references.pmid: 17597331
references.citation: Trends Immunol. 2011 Jan;32(1):19-25
references.pmid: 21067974