title: Genome-wide association study of the five-factor model of personality in young Korean women.
abstract: Personality is a determinant of behavior and lifestyle associated with health and human diseases. Although personality is known to be a heritable trait, its polygenic nature has made the identification of genetic variants elusive. We performed a genome-wide association study on 1089 Korean women aged 18-40 years whose personality traits were measured with the Revised NEO Personality Inventory for the five-factor model of personality. To reduce environmental factors that may influence personality traits, this study was restricted to young adult women. In the discovery phase, we identified variants of PTPRD (protein tyrosine phosphatase, receptor type D) that associated this gene with the Openness domain. Other genes that were previously reported to be associated with neurological phenotypes were also associated with personality traits. In particular, DRD1 and OR1A2 were linked to Neuroticism, NKAIN2 with Extraversion, HTR5A with Openness and DRD3 with Agreeableness. Data from our replication study of 2090 subjects confirmed the association between OR1A2 and Neuroticism. We first identified and confirmed a novel region on OR1A2 associated with Neuroticism [corrected]. Candidate genes for psychiatric disorders were also enriched. These findings contribute to our understanding of the genetic architecture of personality traits and provide critical clues to the neurobiological mechanisms that influence them.
authors.affiliation: Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, Korea.
authors.forename: Han-Na
authors.initials: HN
authors.lastname: Kim
authors.forename: Seung-Ju
authors.initials: SJ
authors.lastname: Roh
authors.forename: Yeon Ah
authors.initials: YA
authors.lastname: Sung
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Chung
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Juhee
authors.initials: J
authors.lastname: Cho
authors.forename: Hocheol
authors.initials: H
authors.lastname: Shin
authors.forename: Hyung-Lae
authors.initials: HL
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D000075384:Neuroticism; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D017447:Receptors, Dopamine D1 / Q000235:genetics; D050637:Receptors, Dopamine D3 / Q000235:genetics; D056910:Republic of Korea; D055815:Young Adult
chemical_list: C583260:DRD1 protein, human; C493593:DRD3 protein, human; D008565:Membrane Proteins; C460140:NKAIN2 protein, human; D017447:Receptors, Dopamine D1; D050637:Receptors, Dopamine D3