title: Apraxia and Alzheimer's disease: review and perspectives.
abstract: Apraxia is one of the cognitive deficits that characterizes Alzheimer's disease. Despite its prevalence and relevance to diagnosing Alzheimer's disease, this topic has received little attention and is without comprehensive review. The review herein is aimed to fill this gap by first presenting an overview of the impairment caused in different clinical situations: pantomime of tool use, single tool use, real tool use, mechanical problem solving, function and manipulation knowledge tasks, and symbolic/meaningless gestures. On the basis of these results, we then propose alternative interpretations regarding the nature of the underlying mechanisms impaired by the disease. Also presented are principal methodological issues precluding firm conclusions from being drawn.
authors.affiliation: Laboratoire d'Étude des Mécanismes Cognitifs (EA 3082), Institut de Psychologie, Université Lyon 2, 5, avenue Pierre Mendès-France, 69676 Bron Cedex, France. mathieu.lesourd@chu-lyon.fr
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lesourd
authors.forename: Didier
authors.initials: D
authors.lastname: Le Gall
authors.forename: Josselin
authors.initials: J
authors.lastname: Baumard
authors.forename: Bernard
authors.initials: B
authors.lastname: Croisile
authors.forename: Christophe
authors.initials: C
authors.lastname: Jarry
authors.forename: François
authors.initials: F
authors.lastname: Osiurak
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D001072:Apraxias / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D001519:Behavior / Q000502:physiology; D006801:Humans; D019359:Knowledge; D019563:Mechanics; D008606:Mental Processes / Q000502:physiology; D009483:Neuropsychological Tests; D009633:Nonverbal Communication; D015995:Prevalence; D011597:Psychomotor Performance / Q000502:physiology; D053001:Tool Use Behavior
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