title: Immunostimulating effects of extract of Acanthopanax sessiliflorus.
abstract: As malfunction/absence of immune cells causes a variety of immunosuppressive disorders and chemical synthetic drugs for curing these diseases have many adverse effects, vigorous studies are being conducted. The Acanthopanax family has been used as traditional medicines for gastric ulcer, diabetes, etc. and culinary materials in East-South Asia. In this study, the immunostimulating properties of A. sessiliflorus were evaluated. A. sessiliflorus increased not only the splenocyte number but also immune-related cytokines such as TNF-α. However, it could not upregulate the expressions of IFN-γ and IL-2. A. sessiliflorus increased the swimming time, and comparison of organ weights relative to body weights for immune-related organs such as the spleen and thymus after a forced swim test showed that it could recover the spleen and thymus weights. It also increased the expression of TNF-α and slightly increased the concentration of IFN-γ but not IL-2. From the results, we concluded that as A. sessiliflorus has not only a host defense effect but also a stress-ameliorating property, further study it will be a promising material of immunostimulating material.
authors.affiliation: Huvet Co., Ltd., #203 Wonkwang University Business Incubator Center, 344-2 Shinyoung-dong, Iksan, Jeonbuk 570-749 Korea.
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Shin
authors.forename: Hak-Yong
authors.initials: HY
authors.lastname: Lee
authors.forename: Bong-Gun
authors.initials: BG
authors.lastname: Lee
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Park
authors.forename: Dae-In
authors.initials: DI
authors.lastname: Moon
authors.forename: Gyo-Chang
authors.initials: GC
authors.lastname: Goo
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Kwon
authors.forename: Hye-Jeong
authors.initials: HJ
authors.lastname: Yang
authors.forename: Ok-Jin
authors.initials: OJ
authors.lastname: Kim
authors.forename: Hong-Geun
authors.initials: HG
authors.lastname: Oh
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D049109:Cell Proliferation; D028001:Eleutherococcus; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013312:Stress, Physiological / Q000187:drug effects; D013550:Swimming; D013950:Thymus Gland / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma
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