title: Gastric lipase secretion in children with gastritis.
abstract: Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL) in gastric juice in healthy adolescents and in patients with gastritis. The adolescents were allocated to three groups: the first including patients with Helicobacter pylori gastritis (HPG; n = 10), the second including patients with superficial gastritis caused by pathogens other than H. pylori (non-HPG; n = 14) and the control group including healthy adolescents (n = 14). Activity of HGL was measured in gastric juice collected during endoscopy. Plasma concentrations of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured in all adolescents. Activity of HGL in the non-HPG group was significantly lower than in the HPG group (p < 0.005) and the control group (p < 0.005). Mean plasma GIP levels in the control group were lower than in the non-HPG group (p < 0.003) and the HPG group (p < 0.01). We conclude that the regulation of HGL secretion by GLP-1 and CCK is altered in patients with gastritis. Moreover, GIP is a potent controller of HGL activity, both in healthy subjects and in patients with gastritis.
authors.affiliation: Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Wielicka St. 265, Krakow 30-663, Poland. p.tomasik@uj.edu.pl
authors.forename: Przemyslaw J
authors.initials: PJ
authors.lastname: Tomasik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wędrychowicz
authors.forename: Iwona
authors.initials: I
authors.lastname: Rogatko
authors.forename: Andrzej
authors.initials: A
authors.lastname: Zając
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Fyderek
authors.forename: Krystyna
authors.initials: K
authors.lastname: Sztefko
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D002766:Cholecystokinin / Q000097:blood; D005215:Fasting; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D005756:Gastritis / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000201:enzymology* / Q000382:microbiology; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D016481:Helicobacter Infections / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008049:Lipase / Q000378:metabolism*; D055815:Young Adult
chemical_list: D002766:Cholecystokinin; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1; D008049:Lipase; C485982:LIPF protein, human
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