title: Possible involvement of human bocavirus 1 in the death of a middle-aged immunosuppressed patient.
abstract: An immunosuppressed 61-year-old man went to the hospital with fever, nonproductive cough, and increasing shortness of breath. The subject died 8 days later of respiratory complications. PCR of respiratory samples as well as a blood sample revealed exceptionally high DNA levels of the emerging pathogen, human bocavirus 1 (HBoV1), a recently found pathogen associated with respiratory symptoms in young children. We describe the clinical progression of the case and discuss the potential role of HBoV1 in the outcome.
authors.affiliation: Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Sadeghi
authors.forename: Kalle
authors.initials: K
authors.lastname: Kantola
authors.forename: Damian P J
authors.initials: DP
authors.lastname: Finnegan
authors.forename: Conall
authors.initials: C
authors.lastname: McCaughey
authors.forename: Lea
authors.initials: L
authors.lastname: Hedman
authors.forename: Maria
authors.initials: M
authors.lastname: Söderlund-Venermo
authors.forename: Klaus
authors.initials: K
authors.lastname: Hedman
mesh_terms: D001769:Blood / Q000821:virology; D012634:Bodily Secretions / Q000821:virology; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D017809:Fatal Outcome; D056661:Human bocavirus / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010322:Parvoviridae Infections / Q000175:diagnosis* / Q000473:pathology* / Q000821:virology; D016133:Polymerase Chain Reaction; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000473:pathology* / Q000821:virology; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral
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