title: Metabolic syndrome in pediatric cancer survivors: a mechanistic review.
abstract: Pediatric cancer survivors have increased risk of obesity, hypertension, dyslipidemia, and type 2 diabetes, leading to premature cardiovascular disease (CVD). Multiple tissues that are involved in glucose homeostasis and lipid metabolism are adversely affected by chemotherapy. This review highlights the relevant tissue and molecular end-organ effects of therapy exposures and synthesizes the current understanding of the mechanisms underlying CVD risk in this vulnerable population. The review also approaches the topic from a developmental perspective, with the goal of providing a translational approach to identifying the antecedents of overt CVD among survivors of pediatric cancer.
authors.affiliation: Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona; Department of Child Health, UA College of Medicine-Phoenix, Phoenix, Arizona.
authors.forename: Galit P
authors.initials: GP
authors.lastname: Rosen
authors.forename: Hoai-Trinh
authors.initials: HT
authors.lastname: Nguyen
authors.forename: Gabriel Q
authors.initials: GQ
authors.lastname: Shaibi
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D024821:Metabolic Syndrome / Q000209:etiology* / Q000503:physiopathology*; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D017741:Survivors
chemical_list: D000970:Antineoplastic Agents
keywords: adolescents; cardiovascular disease; children; metabolic syndrome; pediatric cancer survivor