title: Novel approach for bacteremia detection in patients with end-stage renal failure undergoing hemodialysis.
abstract: Severe systemic infections are one of the leading causes of death in patients with end-stage renal disease and are often associated with hospitalization. Since bacteria can be identified in used hemofilters in an ICU setting, it was investigated whether this method might be useful in patients undergoing regular intermittent hemodialysis. By analyzing used hemodialyzers in (n = 13) patients, we identified systemic bacteremia in two patients (15.4%) while corresponding blood cultures were negative. In two further patients, positive microbiological findings from hemodialyzers appeared to be of unclear clinical relevance. Cultures from hemodialyzers might be an add-on approach for the identification of bacteria in the blood stream of patients undergoing regular intermittent hemodialysis.
authors.affiliation: Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena - Germany and Clinic for Anesthesiology and Intensive Care, Jena University Hospital, Jena - Germany.
authors.forename: Gordon P
authors.initials: GP
authors.lastname: Otto
authors.forename: Madlen
authors.initials: M
authors.lastname: Kropf
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rödel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lösche
authors.forename: Christiane
authors.initials: C
authors.lastname: Rüster
authors.forename: Ralf A
authors.initials: RA
authors.lastname: Claus
authors.forename: Maik
authors.initials: M
authors.lastname: Sossdorf
authors.forename: Martin
authors.initials: M
authors.lastname: Busch
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D007688:Kidneys, Artificial / Q000382:microbiology*; D006435:Renal Dialysis