title: AEG-1/MTDH/LYRIC: clinical significance.
abstract: "Gain-of-function" and "loss-of-function" studies in human cancer cells and analysis of a transgenic mouse model have convincingly established that AEG-1/MTDH/LYRIC performs a seminal role in regulating proliferation, invasion, angiogenesis, metastasis, and chemoresistance, the salient defining hallmarks of cancer. These observations are strongly buttressed by clinicopathologic correlations of AEG-1/MTDH/LYRIC expression in a diverse array of cancers distinguishing AEG-1/MTDH/LYRIC as an independent biomarker for highly aggressive metastatic disease with poor prognosis. AEG-1/MTDH/LYRIC has been shown to be a marker predicting response to chemotherapy, and serum anti-AEG-1/MTDH/LYRIC antibody titer also serves as a predictor of advanced stages of aggressive cancer. However, inconsistent findings have been reported regarding the localization of AEG-1/MTDH/LYRIC protein in the nucleus or cytoplasm of cancer cells and the utility of nuclear or cytoplasmic AEG-1/MTDH/LYRIC to predict the course and prognosis of disease. This chapter provides a comprehensive analysis of the existing literature to emphasize the common and conflicting findings relative to the clinical significance of AEG-1/MTDH/LYRIC in cancer.
authors.affiliation: Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA. dsarkar@vcu.edu
authors.forename: Devanand
authors.initials: D
authors.lastname: Sarkar
authors.forename: Paul B
authors.initials: PB
authors.lastname: Fisher
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000473:pathology / Q000502:physiology; D006258:Head and Neck Neoplasms / Q000209:etiology; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics; D009420:Nervous System / Q000473:pathology; D009424:Nervous System Physiological Phenomena; D011379:Prognosis; D016601:RNA-Binding Proteins; D012143:Respiratory Physiological Phenomena; D014566:Urogenital System / Q000473:pathology / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins
keywords: AEG-1/MTDH/LYRIC; Cancer; Clinicopathological correlation; Metastasis; Prognosis
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