title: Quantification of structural compliance of aged human and porcine aortic root tissues.
abstract: The structural compliance of the aortic root has a significant implication for valve procedures such as transcatheter aortic valve implantation and valve-sparing aortic root replacement. However, a detailed quantification of human aortic root structural compliance, particularly in different regions, has been incomplete. In this study, the structural properties of human aortic roots (81 ± 8.74 years, n = 10) were characterized and compared with those of porcine ones (6-9 months, n = 10) using a vessel pressure-inflation test. The test involved tracking three-dimensional deformation of the markers affixed on the different surface regions of the aortic roots, including the three sinuses: the noncoronary sinus (NCS), the left-coronary sinus (LCS), and the right-coronary sinus (RCS), and at three regions along the longitudinal direction of each sinus: the upper sinus (US), the middle sinus (MS), and the lower sinus (LS), and the ascending aorta (AA) region above the NCS. We found that tissue stiffness in physiological pressure range was similar among the three human sinuses. A variation in regional structural stiffness of human aorta was observed. In the circumferential direction, the LS regions were the stiffest in the LCS and RCS, whereas NCS had relatively uniform stiffness. In the longitudinal direction, the human AA regions were more compliant than all sinuses. There was a significant difference in tissue stiffness between human and porcine aortic tissues, suggesting that the mechanical properties of porcine tissues may not be analogous to aged human ones.
authors.affiliation: Tissue Mechanics Laboratory, Biomedical Engineering Program and Department of Mechanical Engineering, University of Connecticut, Storrs, Connecticut, 06269.
authors.forename: Kewei
authors.initials: K
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Thuy
authors.initials: T
authors.lastname: Pham
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000818:Animals; D001011:Aorta / Q000502:physiology*; D003187:Compliance; D005260:Female; D006801:Humans; D008297:Male; D013552:Swine
keywords: aortic root compliance; direct linear transformation; heart valve mechanics; inflation test; surface deformation
references.citation: Ann Biomed Eng. 2002 Nov-Dec;30(10):1281-90
references.pmid: 12540204
references.citation: Radiology. 1992 Apr;183(1):151-4
references.pmid: 1549662
references.citation: Ann Biomed Eng. 2003 Dec;31(11):1372-82
references.pmid: 14758928
references.citation: Scand Cardiovasc J. 2013 Jun;47(3):145-53
references.pmid: 23098267
references.citation: Phys Med Biol. 1995 Oct;40(10):1577-97
references.pmid: 8532741
references.citation: Eur J Cardiothorac Surg. 2009 Nov;36(5):813-7
references.pmid: 19682918
references.citation: Med Biol Eng Comput. 1999 Mar;37(2):202-7
references.pmid: 10396824
references.citation: Catheter Cardiovasc Interv. 2007 Mar 1;69(4):525-31
references.pmid: 17323355
references.citation: Med Eng Phys. 2009 Mar;31(2):234-43
references.pmid: 18786848
references.citation: J Heart Valve Dis. 2002 Sep;11(5):680-6; discussion 686-7
references.pmid: 12358405
references.citation: Eur J Cardiothorac Surg. 2002 Oct;22(4):497-503
references.pmid: 12297162
references.citation: Circulation. 1999 Nov 9;100(19 Suppl):II54-62
references.pmid: 10567279
references.citation: J Mech Behav Biomed Mater. 2012 Feb;6:21-9
references.pmid: 22301170
references.citation: J Heart Valve Dis. 2008 Nov;17(6):606-13
references.pmid: 19137790
references.citation: J Thorac Cardiovasc Surg. 2009 Jun;137(6):1363-9
references.pmid: 19464449
references.citation: Ann Thorac Surg. 2010 Jun;89(6):1981-8
references.pmid: 20494060
references.citation: Surg Endosc. 2001 Mar;15(3):232-41
references.pmid: 11344421
references.citation: Comput Methods Biomech Biomed Engin. 2009 Jun;12(3):353-69
references.pmid: 19396729
references.citation: Catheter Cardiovasc Interv. 2009 Sep 1;74(3):514-9
references.pmid: 19434747
references.citation: J Appl Physiol (1985). 2009 Apr;106(4):1338-46
references.pmid: 19179652
references.citation: Eur J Cardiothorac Surg. 2006 May;29(5):703-8
references.pmid: 16600616
references.citation: J Biomech Eng. 1996 Feb;118(1):62-73
references.pmid: 8833076
references.citation: Med Eng Phys. 2010 Mar;32(2):212-21
references.pmid: 20060766
references.citation: Ann Biomed Eng. 2001 Nov;29(11):963-73
references.pmid: 11791679
references.citation: Ann Thorac Surg. 2008 May;85(5):1631-8
references.pmid: 18442553
references.citation: J Thorac Cardiovasc Surg. 2002 Apr;123(4):768-76
references.pmid: 11986605
references.citation: Catheter Cardiovasc Interv. 2008 Jul 1;72(1):125-31
references.pmid: 18561162
references.citation: Ann Thorac Surg. 1995 Aug;60(2 Suppl):S384-90
references.pmid: 7646193
references.citation: Ann Thorac Surg. 2006 Jul;82(1):110-6
references.pmid: 16798200
references.citation: Dig Surg. 2011;28(3):205-9
references.pmid: 21540608
references.citation: IEEE Trans Biomed Eng. 2008 Mar;55(3):848-56
references.pmid: 18334376
references.citation: J Med Eng Technol. 2004 May-Jun;28(3):95-103; discussion 104
references.pmid: 15204613
references.citation: J Biomech Eng. 2005 Nov;127(6):905-14
references.pmid: 16438226
references.citation: J Am Coll Cardiol. 2005 Jul 19;46(2):360-5
references.pmid: 16022968
references.citation: IEEE Trans Biomed Eng. 2007 Mar;54(3):349-59
references.pmid: 17355046
references.citation: N Engl J Med. 1997 May 29;336(22):1541-7
references.pmid: 9164809
references.citation: J Heart Valve Dis. 2003 Nov;12(6):781-9
references.pmid: 14658821
references.citation: Stroke. 2009 Jul;40(7):2552-6
references.pmid: 19478233
references.citation: Heart. 2000 Apr;83(4):376-80
references.pmid: 10722531
references.citation: J Card Surg. 1991 Dec;6(4):482-9
references.pmid: 1815773
references.citation: Am J Physiol. 1994 Mar;266(3 Pt 2):H1027-33
references.pmid: 8160806