title: 45S5 Bioglass®-derived scaffolds coated with organic-inorganic hybrids containing graphene.
abstract: Highly porous 45S5 Bioglass®-based scaffolds fabricated by a foam replication technique were coated with electrically conductive organic-inorganic hybrid layers containing graphene by a solution method. α,ω-Triethoxysilane terminated poly (ethylene glycol) and tetraethoxysilane were used as the precursors of the organic-inorganic hybrid coatings, that contained 1.5 wt.% of homogeneously dispersed graphene nanoplatelets. The resulting coated scaffolds retained their original high porosity and interconnected pore structure after coating. The presence of graphene did not impair the bioactivity of the scaffolds in simulated body fluid. Initial tests carried out using MG-63 cells demonstrated that both uncoated scaffolds and scaffolds coated with organic/inorganic hybrids containing graphene offered the cultured cells an adequate surface for cell attachment, spreading and expression of extracellular matrix. The results showed that scaffolds coated with graphene are biocompatible and they can support cellular activity. The electrical conductivity introduced by the coating might have the potential to increase tissue growth when cell culture is carried out under an applied electric field.
authors.affiliation: Department of Engineering Enzo Ferrari, University of Modena and Reggio Emilia, Strada Vignolese 905/A, 41125 Modena, Italy. paola.fabbri@unimore.it
authors.forename: Paola
authors.initials: P
authors.lastname: Fabbri
authors.forename: Luca
authors.initials: L
authors.lastname: Valentini
authors.forename: Jasmin
authors.initials: J
authors.lastname: Hum
authors.forename: Rainer
authors.initials: R
authors.lastname: Detsch
authors.forename: Aldo R
authors.initials: AR
authors.lastname: Boccaccini
mesh_terms: D002516:Ceramics / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D017886:Durapatite / Q000737:chemistry; D055119:Elastic Modulus / Q000187:drug effects; D005898:Glass; D006108:Graphite / Q000494:pharmacology*; D006244:Hardness / Q000187:drug effects; D006801:Humans; D007287:Inorganic Chemicals / Q000494:pharmacology*; D008422:Materials Testing; D018613:Microscopy, Confocal; D009930:Organic Chemicals / Q000494:pharmacology*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D007287:Inorganic Chemicals; D009930:Organic Chemicals; C425330:bioactive glass 45S5; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D006108:Graphite; D017886:Durapatite
keywords: 45S5 Bioglass®; Cell ingrowth; Graphene; Organic–inorganic hybrid coatings; Scaffolds