title: Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype.
abstract: Immunoligands for stimulatory natural killer (NK)-cell receptors can be targeted to the surface of malignant cells by fusing them to antibody fragments. Mimicking an "induced-self" phenotype, such recombinant immunoligands signal danger, trigger NK-cell cytotoxicity and synergistically enhance antibody-dependent cellular cytotoxicity. These findings may be translated into novel immunotherapeutic approaches against cancer.
authors.affiliation: Division of Stem Cell Transplantation and Immunotherapy; 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Kellner
authors.forename: Martin
authors.initials: M
authors.lastname: Gramatzki
authors.forename: Matthias
authors.initials: M
authors.lastname: Peipp
keywords: ADCC; NK cells; NKG2D; NKp30; antibody
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