title: Adipokines during early abstinence of crack cocaine in dependent women reporting childhood maltreatment.
abstract: Childhood maltreatment has been associated with addiction and immune dysregulation, although neurobiological substrates underlying this association remain largely unknown. The aim of the study was to compare plasma levels of adipokines during early abstinence in crack cocaine dependent women with (CM+) and without history of childhood maltreatment (CM-). One hundred four crack cocaine female users were followed for 20 days in a detoxification inpatient treatment unit. Plasma levels of adiponectin, resistin and leptin were assessed every 7 days during 3 weeks of follow-up. The Childhood Trauma Questionnaire (CTQ) retrospectively assessed childhood maltreatment history. A healthy control group was included to provide adipokines reference values (HC). All crack users increased leptin plasma levels during early abstinence despite concentrations remained lower in comparison with non-users group. Crack users reporting childhood maltreatment exhibited a significant reduction in plasma levels of adiponectin and resistin when compared to CM- group. In addition, only CM- participants increased plasma levels of adiponectin during detoxification. This is the first study evaluating adipokines during crack cocaine abstinence. Our results suggest a modulator effect of childhood maltreatment on inflammatory status in treatment-seeking crack cocaine dependents during early abstinence.
authors.affiliation: Centre of Studies and Research in Traumatic Stress, Pontifical Catholic University of Rio Grande do Sul, Av. Ipiranga, 6681 Prédio 11 Sala 936, Porto Alegre, RS 90619-900, Brazil.
authors.forename: Mateus L
authors.initials: ML
authors.lastname: Levandowski
authors.forename: Thiago W
authors.initials: TW
authors.lastname: Viola
authors.forename: Saulo G
authors.initials: SG
authors.lastname: Tractenberg
authors.forename: Antônio L
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Elisa
authors.initials: E
authors.lastname: Brietzke
authors.forename: Moisés E
authors.initials: ME
authors.lastname: Bauer
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Grassi-Oliveira
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D054523:Adult Survivors of Child Abuse; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D019970:Cocaine-Related Disorders / Q000097:blood / Q000523:psychology / Q000628:therapy; D016578:Crack Cocaine / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D052243:Resistin / Q000097:blood*; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
chemical_list: D054392:Adipokines; D015415:Biomarkers; D016578:Crack Cocaine; D020738:Leptin; D052243:Resistin
keywords: Adiponectin; Child abuse; Follow-up study; Immune system; Inflammation; Leptin; Substance-related disorders