title: Early pregnancy failure as a training tool for chorionic villus sampling.
abstract: OBJECTIVE
  The goal of this study is to evaluate the success of a training program in chorionic villus sampling (CVS) of early pregnancy failure (EPF) for maternal-fetal medicine (MFM) fellows.
  
  
  METHODS
  We conducted a retrospective review of a new training program in CVS for MFM fellows. Women with EPF up to 13 weeks estimated gestational age were offered inclusion in our program and counseled on alternatives. Transcervical CVS was performed for both fellow education and cytogenetic diagnosis. The primary outcome was a successful diagnosis, and the secondary outcome was cell growth by fellow experience.
  
  
  RESULTS
  Thirty-nine patients diagnosed with EPF from December 2011 to March 2013 underwent CVS. Villi obtained via CVS yielded a diagnosis in 62% of cases. CVS samples with successful karyotype had more villi but were otherwise similar. CVS by experience showed a trend towards increased success and villi volume after the first five procedures. Abnormal results were obtained in 72% of cases, 15% of which led to changes in care.
  
  
  CONCLUSIONS
  CVS of EPF is an option for the training of MFM fellows as it was acceptable to most patients, and the majority of CVS specimens yielded a karyotype diagnosis.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Thomas Jefferson University, PA, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Nicholas
authors.forename: Kelly
authors.initials: K
authors.lastname: Orzechowski
authors.forename: Sushma
authors.initials: S
authors.lastname: Potti
authors.forename: Jason
authors.initials: J
authors.lastname: Baxter
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Berghella
authors.forename: Stuart
authors.initials: S
authors.lastname: Weiner
mesh_terms: D000328:Adult; D015193:Chorionic Villi Sampling / Q000592:standards / Q000706:statistics & numerical data; D002983:Clinical Competence / Q000706:statistics & numerical data; D020732:Cytogenetic Analysis; D004501:Education, Medical / Q000379:methods*; D020964:Embryo Loss / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods; D012189:Retrospective Studies; D055815:Young Adult