title: IgG and IgA response to Simkania negevensis in sera of patients with respiratory and gastrointestinal symptoms.
abstract: The presence of IgG and IgA antibodies to Simkania negevensis in adult Italian patients with respiratory or gastrointestinal symptoms was investigated by the microimmunofluorescence test. In patients with respiratory infections, IgG (50%) and IgA (13%) seropositivity was consistent with previous data. In patients with gastrointestinal disorders, IgG (68%) and IgA (18%) seroprevalence was significantly higher than in healthy controls. These results, in association with the previously described detection of S. negevensis in water sources, could suggest an oral route of infection other than droplets or close contact, and a possible association of S. negevensis with gastrointestinal infections.
authors.affiliation: Section of Microbiology DESOS, Policlinico S. Orsola, University of Bologna, Bologna, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Donati
authors.forename: Natascia
authors.initials: N
authors.lastname: Fiani
authors.forename: Antonietta
authors.initials: A
authors.lastname: Di Francesco
authors.forename: Maria
authors.initials: M
authors.lastname: Di Paolo
authors.forename: Manuela
authors.initials: M
authors.lastname: Vici
authors.forename: Roberto
authors.initials: R
authors.lastname: Cevenini
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D016022:Case-Control Studies; D002695:Chlamydiales / Q000276:immunology*; D003429:Cross Reactions; D005455:Fluorescent Antibody Technique; D005767:Gastrointestinal Diseases / Q000382:microbiology*; D016905:Gram-Negative Bacterial Infections / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000097:blood*; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood*; D007558:Italy; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000382:microbiology*; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G