title: Anemia and type 2 diabetes mellitus associated with peripheral arterial disease progression in Chinese male patients.
abstract: OBJECTIVE
  Peripheral arterial disease (PAD) is a chronic occlusive disease mainly occurred in elderly adults. Arteriosclerosis obliterans (ASO) mainly occurring from small or medium sized arteries of the lower extremities is one of the most common causes of PAD. The gender-related differences of circulating risk factors in diabetic patients with ASO in China remain unknown. The aim of this study is to investigate the gender-related differences in the pattern of several potential risk factors between male and female patients with ASO and type 2 diabetes mellitus (T2D).
  
  
  METHODS
  Clinical profiles and risk factors were analyzed in 323 Chinese patients with ASO and 112 patients were confirmed with T2D. Severities of limb ischemia were staged according to Fontaine classification.
  
  
  RESULTS
  The significant inverse correlation was seen between the increased age and hemoglobin. The significant positive correlation was seen between the increased age, urea and creatinine both in the non-diabetic and diabetic male patients. The expression levels of hemoglobin significantly correlate with the classification of Fontaine clinical symptoms in Chinese male patients with T2D/ASO.
  
  
  CONCLUSIONS
  The study is the first report indicating that the gender-related differences of circulating risk factors are associated with T2D patients with ASO in China. Anemia in Chinese male patients with T2D/ASO may play an important role in peripheral arterial disease progression.
authors.affiliation: Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Dang
authors.forename: Yin
authors.initials: Y
authors.lastname: Xia
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Li
authors.forename: Danny C W
authors.initials: DC
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000150:complications*; D044466:Asian People; D002681:China; D003710:Demography; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D018450:Disease Progression; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000150:complications* / Q000473:pathology*; D018709:Statistics, Nonparametric
chemical_list: D006454:Hemoglobins
keywords: Anemia and type 2 diabetes mellitus; Arteriosclerosis obliterans; Peripheral arterial disease