title: Serum fatty acids and incidence of ischemic stroke among postmenopausal women.
abstract: OBJECTIVE
  Although studies have linked types of fatty acids with coronary heart disease, data on individual fatty acids and risk of ischemic stroke are limited. We aimed to examine the associations between serum fatty acid concentrations and incidence of ischemic stroke and its subtypes.
  
  
  METHODS
  We conducted a prospective case-control study nested in the Women's Health Initiative Observational Study cohort of postmenopausal US women aged 50 to 79 years. Between 1993 and 2003, incident cases of ischemic stroke were matched 1:1 to controls on age, race, and length of follow-up (964 matched pairs). Conditional logistic regression was used to estimate odds ratios and 99.9% confidence intervals (CI) for ischemic stroke and its subtypes.
  
  
  RESULTS
  The multivariable-adjusted odds ratios and 99.9% CI of ischemic stroke associated with a 1-SD increment in serum fatty acid concentration were 1.38 (99.9% CI, 1.05-1.83) for linoelaidic acid (18:2tt, SD=0.04%), 1.27 (99.9% CI, 1.06-1.51) for palmitic acid (16:0, SD=2.74%), 1.20 (99.9% CI, 1.01-1.43) for oleic acid (18:1n9, SD=2.32%), 0.72 (99.9% CI, 0.59-0.87) for docosapentaenoic acid (22:5n3, SD=0.18%), 0.72 (99.9% CI, 0.59-0.87) for docosahexaenoic acid (22:6n3, SD=0.91%), and 0.81 (99.9% CI, 0.67-0.98) for arachidonic acid (20:4n6, SD=2.02%). These associations were generally consistent for atherothrombotic and lacunar stroke but not cardioembolic stroke.
  
  
  CONCLUSIONS
  These findings suggest that individual serum trans, saturated, and monounsaturated fatty acids are positively associated with particular ischemic stroke subtypes, whereas individual n3 and n6 polyunsaturated fatty acids are inversely associated.
authors.affiliation: From the Department of Epidemiology, University of North Carolina, Chapel Hill, NC (S.Y., W.R.R., W.R., K.H.); National Centers for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD (S.Y.); Department of Neurology, University of South Carolina, Columbia, SC (S.S.); Fred Hutchinson Cancer Research Center, Seattle, WA (L.F.T.); Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA (R.W.E.); Department of Epidemiology, Albert Einstein College of Medicine, Bronx, NY (S.W.S.); and Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN (K.H.).
authors.forename: Sirin
authors.initials: S
authors.lastname: Yaemsiri
authors.forename: Souvik
authors.initials: S
authors.lastname: Sen
authors.forename: Lesley F
authors.initials: LF
authors.lastname: Tinker
authors.forename: Whitney R
authors.initials: WR
authors.lastname: Robinson
authors.forename: Rhobert W
authors.initials: RW
authors.lastname: Evans
authors.forename: Wayne
authors.initials: W
authors.lastname: Rosamond
authors.forename: Sylvia
authors.initials: S
authors.lastname: Wasserthiel-Smoller
authors.forename: Ka
authors.initials: K
authors.lastname: He
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000453:epidemiology; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D012189:Retrospective Studies; D020521:Stroke / Q000097:blood* / Q000453:epidemiology
chemical_list: D005227:Fatty Acids
keywords: omega-3; omega-6; postmenopausal; serum fatty acids; women
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