title: The relationship between coenzyme Q10 and severity of coronary artery disease.
abstract: OBJECTIVE
  To evaluate the relationship between the levels of plasma coenzyme Q10 (CoQ10), a known antioxidant, and severity of the coronary atherosclerosis (AS) measured by Gensini score.
  
  
  METHODS
  Patients with coronary artery disease (CAD) were enrolled to the study between 2010 and 2011 in cardiology outpatient clinics. They were admitted for diagnostic coronary angiography or angioplasty for typical indications. The Gensini scoring system was used to calculate CAD severity. Serum CoQ10, total cholesterol (TC), HDL cholesterol, LDL cholesterol, and triglyceride levels were assessed.
  
  
  RESULTS
  One hundred thirteen subjects (83 CAD, 30 controls) were included. The patients with CAD were separated into three groups according to Gensini score. The serum levels of CoQ10, CoQ10/ TC, CoQ10/LDL-C, CoQ10/TG rates in the subjects of mild and severe AS groups were significantly lower than the control group ( p less than 0.016 for all control vs. AS group comparisons). There were no significant differences in serum levels of CoQ10 and CoQ10/ TC, CoQ10/LDL-C, CoQ10/TG rates between the mild and severe AS groups.
  
  
  CONCLUSIONS
  This study revealed that although the serum CoQ10 levels were lower in stable CAD, there was no relationship between the severity of CAD and serum CoQ10 levels in patients with stable angina pectoris.
authors.affiliation: 1Department of Cardiology , School of Medicine of Mustafa Kemal University, Hatay, 2Department of Medical Biochemistry, School of Medicine of Dicle University, Diyarbakır, 3Department of Cardiology, School of Medicine of Dicle University, Diyarbakır; Turkey.
authors.forename: Eyüp
authors.initials: E
authors.lastname: Büyükkaya
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoğlu
authors.forename: Yahya
authors.initials: Y
authors.lastname: Islamoğlu
authors.forename: Habib
authors.initials: H
authors.lastname: Cil
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Karakaş
authors.forename: Adnan Burak
authors.initials: AB
authors.lastname: Akçay
authors.forename: Perihan
authors.initials: P
authors.lastname: Bilen
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kurt
authors.forename: Nihat
authors.initials: N
authors.lastname: Şen
authors.forename: Faruk
authors.initials: F
authors.lastname: Ertas
authors.forename: Nuriye
authors.initials: N
authors.lastname: Mete
mesh_terms: D002784:Cholesterol; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood; D006801:Humans
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol