title: Major peripheral nerve injuries.
abstract: Major peripheral nerve injuries in the upper extremities can result in significant morbidity. Understanding the pathophysiology of these injuries aids in the assessment and planning of appropriate treatment. With limited nerve mobilization, tension-free repairs can often be performed using sutures, fibrin glue, or nerve connectors. Acellular allograft and autograft reconstruction are better for bridging any gaps greater than a few millimeters. Adherence to proper principles of nerve repair improves the chances of achieving a favorable result, although in general these injuries portend a guarded prognosis.
authors.affiliation: Division of Hand Surgery, Department of Orthopaedic Surgery, Virginia Commonwealth University Health System, 1200 East Broad Street, PO Box 980153, Richmond, VA 23298, USA. jisaacs@mcvh-vcu.edu
authors.forename: Jonathan
authors.initials: J
authors.lastname: Isaacs
mesh_terms: D064591:Allografts; D064592:Autografts; D003646:Debridement; D003657:Decision Making; D004576:Electromyography; D015718:Fibrin Tissue Adhesive; D006801:Humans; D008866:Microsurgery; D009121:Muscle Denervation / Q000009:adverse effects; D009133:Muscular Atrophy / Q000209:etiology; D009416:Nerve Regeneration / Q000502:physiology; D059348:Peripheral Nerve Injuries / Q000175:diagnosis / Q000601:surgery*; D010525:Peripheral Nerves / Q000637:transplantation; D019736:Prostheses and Implants; D020127:Recovery of Function / Q000502:physiology; D013536:Suture Techniques; D061665:Time-to-Treatment; D014014:Tissue Adhesives
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives
keywords: Major peripheral nerves; Nerve allograft; Nerve injury; Neurorrhaphy