title: The use of salivary protein secretions as an in vivo model to study Mantel cell lymphoma progression and treatment.
abstract: OBJECTIVE
  The objective of this study was to compare the salivary protein profiles from an individual diagnosed with MCL before, during, and after chemotherapy.
  
  
  METHODS
  Saliva specimens acquire prior, during, and after chemotherapy. Specimens were analyzed using a LC-MS/MS mass spectrometer.
  
  
  RESULTS
  The results of the study suggest salivary protein alterations secondary to MCL and that a number of the proteins were changed as a result of chemotherapeutic intervention suggesting that the treatment, from a proteomic perspective, was efficacious. The study suggests that salivary secretions may be used as in vivo model for studying MCL progression and treatment efficacy.
authors.affiliation: Dental Branch, Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center (UTHSC), Houston, Texas 77054, USA. charles.streckfus@uth.tmc.edu
authors.forename: Charles F
authors.initials: CF
authors.lastname: Streckfus
authors.forename: Jorge
authors.initials: J
authors.lastname: Romaguera
authors.forename: Cynthia
authors.initials: C
authors.lastname: Guajardo-Streckfus
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols; D018450:Disease Progression; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008297:Male; D040901:Proteomics / Q000379:methods*; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis*
chemical_list: D012471:Salivary Proteins and Peptides