title: RNA helicase DHX33 puts a new twist on NLRP3 inflammasome activation.
abstract: The mechanisms by which NLRP3 senses inflammasome-activating stimuli remain poorly defined. In this issue of Immunity, Mitoma et al. (2013) demonstrate that the RNA helicase DHX33 binds to cytosolic dsRNAs to trigger NLRP3 inflammasome activation.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ibrodsky@vet.upenn.edu
authors.forename: Igor E
authors.initials: IE
authors.lastname: Brodsky
mesh_terms: D002352:Carrier Proteins / Q000276:immunology*; D053487:DEAD-box RNA Helicases / Q000276:immunology*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D012313:RNA / Q000276:immunology*
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D012313:RNA; C568925:DHX33 protein, human; D053487:DEAD-box RNA Helicases