title: Distinct expression of Mas1-related G-protein-coupled receptor B4 in dorsal root and trigeminal ganglia--implications for altered behaviors in acid-sensing ion channel 3-deficient mice.
abstract: Mas1-related G-protein-coupled receptors (Mrgprs), comprising more than 50 distinct members, are specifically expressed in primary sensory neurons. Reflecting the diversity and specificity of stimuli they detect, Mrgprs are involved in pain, touch, and itch-related behaviors. Sensory-neuron-specific acid-sensing ion channel 3 (ASIC3) is essential for touch and inflammatory pain, but mice lacking ASIC3 have complex behavioral alterations in various modalities of pain and touch. To understand whether Mrgprs are involved in complex behavioral alterations found in ASIC3-deficient mice, we examined Mrgpr gene expression in ASIC3(-/-) mice. Only MrgprB4 expression has shown significant change. MrgprB4 expression was increased in ASIC3(-/-) dorsal root ganglia (DRG) but decreased in ASIC3(-/-) trigeminal ganglia. The distinct alterations in DRG and trigeminal ganglia imply that MrgprB4 could have multiple functions. Given that MrgprB4 is expressed in neurons that may detect gentle touch and that ASIC3(-/-) mice have altered sensitivity of mechanoreceptors for light touch, the expression change of MrgprB4 is more likely related to the altered touch behaviors of ASIC3(-/-) mice.
authors.affiliation: Department of Life Sciences, National Central University, Jhongda Road 300, 32054, Jhongli, Taiwan.
authors.forename: Ya-Han
authors.initials: YH
authors.lastname: Huang
authors.forename: Chin-Yu
authors.initials: CY
authors.lastname: Chang
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Chen
authors.forename: Chih-Dong
authors.initials: CD
authors.lastname: Yang
authors.forename: Wei-Hsin
authors.initials: WH
authors.lastname: Sun
mesh_terms: D062565:Acid Sensing Ion Channels / Q000235:genetics*; D000818:Animals; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D008297:Male; D008465:Mechanoreceptors / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009619:Nociceptors / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D014110:Touch; D012668:Trigeminal Ganglion / Q000166:cytology / Q000378:metabolism* / Q000502:physiology
chemical_list: C508378:ASIC3 protein, mouse; D062565:Acid Sensing Ion Channels; C000715471:Mas1 protein, mouse; C524074:MrgprB4 protein, mouse; D000090063:Proto-Oncogene Mas; D043562:Receptors, G-Protein-Coupled
references.citation: Br J Pharmacol. 2004 Feb;141(3):423-30
references.pmid: 14718254
references.citation: Cell. 2001 Sep 7;106(5):619-32
references.pmid: 11551509
references.citation: Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10240-5
references.pmid: 9707631
references.citation: Nature. 2013 Jan 31;493(7434):669-73
references.pmid: 23364746
references.citation: Cell. 2009 Dec 24;139(7):1353-65
references.pmid: 20004959
references.citation: J Neurophysiol. 2003 Jan;89(1):513-24
references.pmid: 12522198
references.citation: Nature. 1997 Oct 23;389(6653):816-24
references.pmid: 9349813
references.citation: Proc Natl Acad Sci U S A. 2004 May 4;101(18):7175-80
references.pmid: 15118101
references.citation: J Biol Chem. 2003 Nov 7;278(45):44400-4
references.pmid: 12915402
references.citation: EMBO J. 2008 Nov 19;27(22):3047-55
references.pmid: 18923424
references.citation: J Biol Chem. 1997 Aug 22;272(34):20975-8
references.pmid: 9261094
references.citation: Circ Res. 2006 Sep 1;99(5):501-9
references.pmid: 16873722
references.citation: Mol Pain. 2008 Jan 15;4:2
references.pmid: 18197975
references.citation: Pain. 2003 Dec;106(3):229-239
references.pmid: 14659506
references.citation: Nature. 1997 Mar 13;386(6621):173-7
references.pmid: 9062189
references.citation: Nat Neurosci. 2007 Aug;10(8):946-8
references.pmid: 17618277
references.citation: Mol Cell Neurosci. 2007 Oct;36(2):195-210
references.pmid: 17720533
references.citation: J Physiol. 1991 Apr;435:41-63
references.pmid: 1770443
references.citation: J Neurosci Res. 1991 Sep;30(1):92-104
references.pmid: 1795410
references.citation: Brain Res. 1993 Nov 19;628(1-2):301-4
references.pmid: 8313159
references.citation: J Biol Chem. 2007 Jun 15;282(24):17325-9
references.pmid: 17430882
references.citation: Neuron. 2005 Jan 6;45(1):17-25
references.pmid: 15629699
references.citation: Mol Pain. 2005 Nov 23;1:35
references.pmid: 16305749
references.citation: Nat Neurosci. 2002 Mar;5(3):201-9
references.pmid: 11850634
references.citation: Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8992-7
references.pmid: 12060708
references.citation: J Neurosci. 2003 Nov 26;23(34):10988-97
references.pmid: 14645495
references.citation: Prog Neurobiol. 2002 Jan;66(1):19-59
references.pmid: 11897404
references.citation: J Biol Chem. 2004 May 28;279(22):23559-64
references.pmid: 15037633
references.citation: Neuron. 1998 Apr;20(4):629-32
references.pmid: 9581756
references.citation: J Neurosci. 2007 Apr 18;27(16):4492-6
references.pmid: 17442834
references.citation: Neuron. 1997 Oct;19(4):849-61
references.pmid: 9354331
references.citation: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):711-6
references.pmid: 11120882
references.citation: Neuron. 1998 Sep;21(3):531-43
references.pmid: 9768840
references.citation: Brain Res. 1990 May 7;515(1-2):331-5
references.pmid: 2113415
references.citation: J Cell Biol. 1999 Feb 8;144(3):435-46
references.pmid: 9971739
references.citation: Neuron. 2001 Dec 20;32(6):1071-83
references.pmid: 11754838
references.citation: J Physiol. 1990 Jul;426:229-40
references.pmid: 2231398
references.citation: J Neurosci. 2002 May 15;22(10):4057-65
references.pmid: 12019325
references.citation: J Neurosci. 2005 Oct 26;25(43):9893-901
references.pmid: 16251436
references.citation: Eur J Neurosci. 1999 Mar;11(3):946-58
references.pmid: 10103088
references.citation: Pain. 2007 May;129(1-2):102-12
references.pmid: 17134831
references.citation: J Neurosci. 1999 Aug 1;19(15):6497-505
references.pmid: 10414978
references.citation: Trends Neurosci. 2003 Sep;26(9):477-83
references.pmid: 12948658
references.citation: Behav Brain Res. 2007 Mar 12;178(1):154-9
references.pmid: 17227682
references.citation: Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8573-8
references.pmid: 12084918
references.citation: Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2326-31
references.pmid: 11842212
references.citation: Brain Res. 2002 Jul 12;943(2):287-91
references.pmid: 12101052
references.citation: Nat Neurosci. 2002 Sep;5(9):900-4
references.pmid: 12145636
references.citation: PLoS One. 2009 Aug 04;4(8):e6508
references.pmid: 19652708
references.citation: Somatosens Mot Res. 2001;18(4):312-21
references.pmid: 11794733
references.citation: Brain Res Mol Brain Res. 2005 May 20;136(1-2):125-33
references.pmid: 15893596
references.citation: J Neurophysiol. 1999 Jun;81(6):2753-63
references.pmid: 10368395
references.citation: Pain. 2005 May;115(1-2):37-49
references.pmid: 15836968
references.citation: Mol Pain. 2009 Jan 07;5:1
references.pmid: 19126241
references.citation: J Cell Mol Med. 2013 Mar;17(3):337-49
references.pmid: 23490035
references.citation: J Neurosci. 2011 Jan 26;31(4):1410-8
references.pmid: 21273425
references.citation: Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10043-8
references.pmid: 12909716
references.citation: Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14740-5
references.pmid: 12397184
references.citation: Neuron. 2002 Jul 3;35(1):135-46
references.pmid: 12123614