title: Treatment of patients with HBV-related decompensated cirrhosis and liver transplanted patients.
abstract: Antiviral therapy using newer nucleos(t)ide analogs with lower resistance rates could suppress hepatitis B virus (HBV) replication, improve liver function in patients with compensated or decompensated cirrhosis, delay or obviate liver transplantation in some patients, and reduce the risk of HBV recurrence. Some form of HBV prophylaxis needs to be continued indefinitely posttransplant. However, in patients with a low-risk of HBV recurrence it is possible to discontinue hepatitis B immunoglobulins and maintain long-term nucleos(t)ide analog therapy. Currently, treatment of posttransplantation hepatitis B is a less important clinical problem than it was historically because effective antiviral therapies exist to rescue patients who failed initial prophylaxis.
authors.affiliation: AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Villejuif F-94800, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Roche
authors.forename: Didier
authors.initials: D
authors.lastname: Samuel
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D058625:End Stage Liver Disease / Q000209:etiology / Q000628:therapy; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000628:therapy*; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000209:etiology / Q000628:therapy*; D016031:Liver Transplantation; D012307:Risk Factors; D055502:Secondary Prevention / Q000379:methods / Q000639:trends
chemical_list: D000998:Antiviral Agents; D007136:Immunoglobulins; C045213:hepatitis B hyperimmune globulin
keywords: Antiviral therapy; Cirrhosis; Entecavir; Hepatitis B; Hepatitis B immunoglobulin; Liver transplantation; Tenofovir