title: Developmental fluoxetine exposure facilitates sexual behavior in female offspring.
abstract: BACKGROUND
  A growing number of infants are being exposed to selective serotonin reuptake inhibitor (SSRI) medications during the perinatal period. SSRIs target the serotoninergic system and are a popular treatment for maternal mood disorders. Serotonin itself plays a key role in the sexual differentiation through its role in the development of the hypothalamic-pituitary-gonadal axis, and previous research has shown that developmental SSRI exposure has an effect on sexual behavior in male offspring.
  
  
  OBJECTIVE
  Our aim was to determine the role of developmental exposure to a popular SSRI medication, fluoxetine, on sexual differentiation of the brain and behavior in female offspring using a rodent model of maternal adversity.
  
  
  METHODS
  Stressed and non-stressed Sprague-Dawley rat dams were chronically treated with either fluoxetine (5 mg/kg/day) or vehicle beginning on postnatal day 1. Four groups of female offspring were used: (1) control + vehicle, (2) control + fluoxetine, (3) prenatal stress + vehicle, and (4) prenatal stress + fluoxetine.
  
  
  RESULTS
  Primary results show that in adult female offspring, developmental fluoxetine exposure facilitates proceptive and receptive behaviors with a significant increase in the number of proceptive behaviors, a significant increase in the lordosis quotient, and a significant decrease in the rejection quotient.
  
  
  CONCLUSIONS
  This research contributes in the understanding of the long-term impact developmental fluoxetine exposure on the hypothalamus-pituitary-gonadal (HPG) system in adult female offspring.
authors.affiliation: School for Mental Health and Neuroscience, Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
authors.forename: Ine
authors.initials: I
authors.lastname: Rayen
authors.forename: Harry W M
authors.initials: HW
authors.lastname: Steinbusch
authors.forename: Thierry D
authors.initials: TD
authors.lastname: Charlier
authors.forename: Jodi L
authors.initials: JL
authors.lastname: Pawluski
mesh_terms: D001003:Anal Canal / Q000033:anatomy & histology; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000254:growth & development; D004958:Estradiol / Q000494:pharmacology; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D005836:Genitalia, Female / Q000033:anatomy & histology; D007150:Immunohistochemistry; D009043:Motor Activity / Q000187:drug effects; D011187:Posture; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012733:Sex Differentiation / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D004958:Estradiol; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors; D014446:Tyrosine 3-Monooxygenase
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