title: The critical role of STIM1-dependent Ca2+ signalling during T-cell development and activation.
abstract: T lymphocytes are key cellular effectors of adaptive immunity able to recognize a virtually limitless number of antigenic peptides and mount an immune response. Ca(2+) signals are crucial to the development and activation of T cells and Stromal Interaction Molecule 1 (STIM1) has been identified as a critical modulator of intracellular Ca(2+) levels in T cells. Although the role of STIM1 in T cell activation has been extensively investigated, the role of STIM1 in T cell development has been somewhat controversial. Indeed, deficiencies in STIM1 expression and function lead to both developmental defects associated with the development of autoimmunity yet also interfere with T cell activation leading to severe combined immunodeficiency signifying a multifaceted role of STIM1 in T cell physiology and pathophysiology.
authors.affiliation: Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, United States.
authors.forename: Elsie
authors.initials: E
authors.lastname: Samakai
authors.forename: Robert
authors.initials: R
authors.lastname: Hooper
authors.forename: Jonathan
authors.initials: J
authors.lastname: Soboloff
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000276:immunology*; D004194:Disease; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008565:Membrane Proteins / Q000378:metabolism*; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D008565:Membrane Proteins
keywords: Calcium signalling; Orai1; PMCA; STIM1; T-cell
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