title: [Gd(CyPic3A)(H2O)2]-: a stable, bis(aquated) and high-relaxivity Gd(III) complex.
abstract: We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(III) complexes of hydration state q = 2. [Gd(CyPic3A)(H2O)2](-) affords an r1 value of 5.70 mM(-1) s(-1) at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Gale
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Kenton
authors.forename: Peter
authors.initials: P
authors.lastname: Caravan
mesh_terms: D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry*; D004355:Drug Stability; D005682:Gadolinium / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D002614:Chelating Agents; D056831:Coordination Complexes; D014867:Water; D005682:Gadolinium
references.citation: Inorg Chem. 2008 Sep 15;47(18):8357-66
references.pmid: 18714983
references.citation: Inorg Chem. 2004 Nov 29;43(24):7588-90
references.pmid: 15554621
references.citation: Inorg Chem. 2001 Apr 23;40(9):2170-6
references.pmid: 11304163
references.citation: Inorg Chem. 2013 Apr 1;52(7):4084-96
references.pmid: 23517079
references.citation: J Am Chem Soc. 2011 Apr 13;133(14):5329-37
references.pmid: 21413801
references.citation: J Am Chem Soc. 2011 Sep 21;133(37):14704-9
references.pmid: 21800868
references.citation: Inorg Chem. 2007 Aug 6;46(16):6632-9
references.pmid: 17625839
references.citation: Acc Chem Res. 2009 Jul 21;42(7):851-62
references.pmid: 19222207
references.citation: Inorg Chem. 2006 Oct 16;45(21):8719-28
references.pmid: 17029383
references.citation: Contrast Media Mol Imaging. 2010 Nov-Dec;5(6):305-8
references.pmid: 20803503
references.citation: Chemistry. 2009;15(7):1696-705
references.pmid: 19130509
references.citation: Anal Chem. 2012 Aug 7;84(15):6278-87
references.pmid: 22624599
references.citation: Chem Soc Rev. 2006 Jun;35(6):512-23
references.pmid: 16729145
references.citation: J Am Chem Soc. 2012 Dec 5;134(48):19858-68
references.pmid: 23157602
references.citation: Chem Rev. 1999 Sep 8;99(9):2293-352
references.pmid: 11749483
references.citation: J Med Chem. 1998 Aug 27;41(18):3546-9
references.pmid: 9719608
references.citation: Invest Radiol. 2010 Oct;45(10):600-12
references.pmid: 20808235
references.citation: Inorg Chem. 2012 Feb 20;51(4):2597-607
references.pmid: 22313334
references.citation: Chemistry. 2004 Jul 19;10(14):3579-90
references.pmid: 15252806
references.citation: Chem Rev. 2005 Jun;105(6):1923-59
references.pmid: 15941206
references.citation: Contrast Media Mol Imaging. 2009 Mar-Apr;4(2):89-100
references.pmid: 19177472
references.citation: Chem Commun (Camb). 2008 Dec 28;(48):6591-3
references.pmid: 19057789
references.citation: Chem Rev. 2010 May 12;110(5):2921-59
references.pmid: 20067234
references.citation: Inorg Chem. 2003 Aug 11;42(16):4930-7
references.pmid: 12895117
references.citation: Acc Chem Res. 2009 Jul 21;42(7):938-47
references.pmid: 19505089