title: Prevention of contamination by biopsy needle track contamination using a novel adriamycin-loaded gelatin sponge.
abstract: BACKGROUND
  The gold standard of tumor diagnosis is histological examination of a biopsy; however, there is concern that tumor cell dissemination along the needle track during percutaneous biopsy can cause local tumor relapse. We aimed to evaluate the value of an adriamycin (ADM)-loaded gelatin sponge in preventing tumor cell contamination along the biopsy needle track.
  
  
  METHODS
  Data were obtained from 40 patients who were diagnosed by core needle biopsy as having osteosarcoma and who were followed up at our hospital between 2008 and 2011. Of the 40 patients, 20 had the needle biopsy tracks filled with ADM-loaded absorbable gelatin sponge immediately after the biopsy specimen was obtained, while the other 20 did not. All 40 patients underwent limb-salvage surgery, and specimens were obtained from the biopsy track for histopathologic examination of multiple sections.
  
  
  RESULTS
  On histological examination, there was less tumor cell contamination along the biopsy tracks in the ADM group.
  
  
  CONCLUSIONS
  Use of ADM-loaded absorbable gelatin sponge may prevent tumor cell contamination of a biopsy track, and reduce the possibility of consequent tumor relapse.
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, 107 Wenhuaxilu, Jinan, Shandong Province 250012, China.
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Li
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Yan
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D001707:Biopsy, Needle / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000601:surgery; D016022:Case-Control Studies; D002648:Child; D004317:Doxorubicin / Q000008:administration & dosage*; D004866:Equipment Contamination / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D005781:Gelatin Sponge, Absorbable; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009366:Neoplasm Seeding; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000175:diagnosis* / Q000601:surgery; D011379:Prognosis; D055815:Young Adult
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin
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