title: Obesity in kidney transplant recipients: association with decline in glomerular filtration rate.
abstract: In this study we aimed to evaluate the influence of obesity in kidney and patient survival and graft function. Retrospective cohort study of kidney transplant recipients performed between 2001 and 2009. The body mass index was calculated at time of transplantation, one and five years after. The main outcomes studied were incidence of delayed graft function, new onset diabetes after transplantation, patient and graft survival, and glomerular filtration rate. The prevalence of obesity and overweight patients were 10.7% and 26.8% respectively, with an increase to 16.9% and 32.5% one year after transplantation. Underweight and obese recipients presented a higher incidence of early graft loss. The incidence of new onset diabetes after transplantation was significantly higher at one and five years in overweight or obese recipients at baseline. Overweight and obese recipients presented significantly lower estimated glomerular filtration rate at five years posttransplantation (p = 0.002). In the Kaplan-Meier analyses no statistically significant differences in patients or grafts survivals were observed. Obese patients have a higher rate of early graft failure and a higher new onset diabetes after transplantation incidence. Also, the finding of decreased glomerular filtration rate is worrisome and perhaps longer follow-up will reveal more graft failures and patients deaths in the group of obese recipients.
authors.affiliation: Post-Graduate Medical Sciences Program, School of Medicine, Universidade Federal do Rio Grande do Sul , Porto Alegre, RS , Brazil .
authors.forename: Thaís Rodrigues
authors.initials: TR
authors.lastname: Moreira
authors.forename: Tayron
authors.initials: T
authors.lastname: Bassani
authors.forename: Gizele
authors.initials: G
authors.lastname: de Souza
authors.forename: Roberto Ceratti
authors.initials: RC
authors.lastname: Manfro
authors.forename: Luiz Felipe Santos
authors.initials: LF
authors.lastname: Gonçalves
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000401:mortality / Q000503:physiopathology*; D012189:Retrospective Studies; D019737:Transplants / Q000503:physiopathology; D055815:Young Adult