title: Chalcone derivatives from the fern Cyclosorus parasiticus and their anti-proliferative activity.
abstract: Three new chalcone derivatives, named parasiticins A-C (1-3), were isolated from the leaves of Cyclosorus parasiticus, together with four known chalcones, 5,7-dihydroxy-4-phenyl-8-(3-phenyl-trans-acryloyl)-3,4-dihydro-1-benzopyran-2-one (4), 2'-hydroxy-4',6'-dimethoxychalcone (5), 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (6), 2',4'-dihydroxy-6'-methoxy-3'-methylchalcone (7). The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of compounds 1-7 were evaluated against six human cancer cell lines in vitro. Compounds 3 and 6 exhibited substantial cytotoxicity against all six cell lines, especially toward HepG2 with the IC₅₀ values of 1.60 and 2.82 μM, respectively. Furthermore, we demonstrated that compounds 3 and 6 could induce apoptosis in the HepG2 cell line, which may contribute significantly to their cytotoxicity.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China; Innovation Institute, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Han
authors.initials: H
authors.lastname: Wei
authors.forename: Xuenong
authors.initials: X
authors.lastname: Zhang
authors.forename: Guanghua
authors.initials: G
authors.lastname: Wu
authors.forename: Xian
authors.initials: X
authors.lastname: Yang
authors.forename: Songwei
authors.initials: S
authors.lastname: Pan
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jinlan
authors.initials: J
authors.lastname: Ruan
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002599:Chalcone / Q000494:pharmacology*; D047188:Chalcones / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D029624:Ferns / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C501649:2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone; D047188:Chalcones; D003374:Coumarins; D010936:Plant Extracts; C588133:parasiticin C; D002599:Chalcone
keywords: Anti-proliferative activity; Chalcone; Cyclosorus parasiticus; HepG2 cell