title: Direct recordings of grid-like neuronal activity in human spatial navigation.
abstract: Grid cells in the entorhinal cortex appear to represent spatial location via a triangular coordinate system. Such cells, which have been identified in rats, bats and monkeys, are believed to support a wide range of spatial behaviors. Recording neuronal activity from neurosurgical patients performing a virtual-navigation task, we identified cells exhibiting grid-like spiking patterns in the human brain, suggesting that humans and simpler animals rely on homologous spatial-coding schemes.
authors.affiliation: School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA. joshua.jacobs@drexel.edu
authors.forename: Joshua
authors.initials: J
authors.lastname: Jacobs
authors.forename: Christoph T
authors.initials: CT
authors.lastname: Weidemann
authors.forename: Jonathan F
authors.initials: JF
authors.lastname: Miller
authors.forename: Alec
authors.initials: A
authors.lastname: Solway
authors.forename: John F
authors.initials: JF
authors.lastname: Burke
authors.forename: Xue-Xin
authors.initials: XX
authors.lastname: Wei
authors.forename: Nanthia
authors.initials: N
authors.lastname: Suthana
authors.forename: Michael R
authors.initials: MR
authors.lastname: Sperling
authors.forename: Ashwini D
authors.initials: AD
authors.lastname: Sharan
authors.forename: Itzhak
authors.initials: I
authors.lastname: Fried
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kahana
mesh_terms: D000200:Action Potentials / Q000502:physiology; D001931:Brain Mapping; D018728:Entorhinal Cortex / Q000166:cytology* / Q000000981:diagnostic imaging / Q000473:pathology; D004827:Epilepsy / Q000473:pathology / Q000601:surgery; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D009068:Movement; D009474:Neurons / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology*; D014057:Tomography, X-Ray Computed; D014584:User-Computer Interface
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