title: Polymorphisms of ERBB2 and breast cancer risk: a meta-analysis of 26 studies involving 35,088 subjects.
abstract: OBJECTIVE
  Several epidemiologic studies have investigated the relationship between the polymorphisms of ERBB2 gene and breast cancer risk. However, the results are inconclusive. This meta-analysis aimed to assess the association between ERBB2 Ile655Val and Ala1170Pro polymorphisms and the susceptibility to breast cancer.
  
  
  METHODS
  Twenty-six studies including 15,940 cases and 19,148 controls were analyzed in this meta-analysis.
  
  
  RESULTS
  Overall, allele contrast (Val vs. Ile) of ERBB2 655 polymorphism produced significant results in worldwide populations (OR = 1.123, 95%CI = 1.01-1.249) and in Caucasian populations (OR = 1.149, 95%CI = 1.002-1.318). In addition, the Val/Val genotype of ERBB2 655 polymorphism was associated with an increase risk of breast cancer in African (Val/Val vs. Ile/Ile OR = 16.031 95%CI = 2.019-127.267; Val/Val vs. Ile/Val + Ile/Ile OR = 16.445 95%CI = 2.059-131.351), but not in Caucasian or Asian individuals.
  
  
  CONCLUSIONS
  ERBB2 655 Val allele would be a risk factor for breast cancer, especially in Caucasian populations. In addition, the Val/Val genotype was a risk factor for breast cancer in African individuals. ERBB2 Ala1170Pro was not associated with breast cancer susceptibility.
authors.affiliation: Mudangjiang Medical University, Mudangjiang, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.forename: Lantao
authors.initials: L
authors.lastname: Liu
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Lang
authors.forename: Shangfu
authors.initials: S
authors.lastname: Guo
authors.forename: Huiling
authors.initials: H
authors.lastname: Gong
authors.forename: Huilin
authors.initials: H
authors.lastname: Guan
authors.forename: Jiutao
authors.initials: J
authors.lastname: Zhang
authors.forename: Binna
authors.initials: B
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000409:Alanine; D000483:Alleles; D044466:Asian People / Q000706:statistics & numerical data; D044383:Black People / Q000706:statistics & numerical data; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007532:Isoleucine; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011392:Proline; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D012307:Risk Factors; D014633:Valine; D044465:White People / Q000706:statistics & numerical data
chemical_list: D000409:Alanine; D007532:Isoleucine; D011392:Proline; D018719:Erb-b2 Receptor Tyrosine Kinases; D014633:Valine; C508053:ERBB2 protein, human
keywords: ERBB2; breast cancer; meta-analysis; polymorphisms