title: Loop electrosurgical excision procedure for the treatment of cervical intraepithelial neoplasia: how much excision is enough?
abstract: This is a retrospective observational study to compare outcomes in patients with cervical intraepithelial neoplasia (CIN) treated with loop electrosurgical excision procedure (LEEP) using combined ectocervical/endocervical resection vs ectocervical resection alone. We demonstrated that additional endocervical resection during loop electrosurgical excision procedure did not significantly lower the risk of subsequent recurrence compared with ectocervical resection alone, in the treatment of CIN. With current published data supporting subsequent increased adverse effects of LEEP on future obstetrical outcomes, endocervical excision should be applied selectively. We recommend that additional endocervical excision should be reserved only for patients with a strong suspicion of underlying endocervical canal involvement based on colposcopic assessment or in patients with unsatisfactory colposcopy, where it is essential to evaluate the endocervical canal.
authors.affiliation: Department of Obstetrics, Gynecology and Newborn Care, Division of Gynecologic Oncology, University of Ottawa, Ottawa, Ontario, Canada. tle@ottawahospital.on.ca
authors.forename: T
authors.initials: T
authors.lastname: Le
authors.forename: R
authors.initials: R
authors.lastname: El-Sugi
authors.forename: W
authors.initials: W
authors.lastname: Hicks-Boucher
authors.forename: J
authors.initials: J
authors.lastname: Weberpals
authors.forename: W
authors.initials: W
authors.lastname: Faught
mesh_terms: D000328:Adult; D002170:Canada / Q000453:epidemiology; D004598:Electrosurgery / Q000379:methods / Q000592:standards* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000601:surgery*