title: Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway.
abstract: Tetramethylpyrazine is used in the treatment of many neurological diseases because of its neuroprotective effect. Here, we demonstrate that administration of tetramethylpyrazine effectively reverses memory deficits induced by scopolamine. Moreover, tetramethylpyrazine preserves postsynaptic protein synthesis and restores cAMP/PKA/CREB pathway signaling deficits. Our study not only explores the actions of tetramethylpyrazine on synapses, but also provides novel evidence for the possible therapeutic use of tetramethylpyrazine in dementia.
authors.affiliation: Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Xiao
authors.initials: X
authors.lastname: Yu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Luo
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Yang
authors.forename: Dong
authors.initials: D
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics; D000242:Cyclic AMP / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000096:biosynthesis / Q000187:drug effects* / Q000235:genetics; D017868:Cyclic AMP-Dependent Protein Kinases / Q000096:biosynthesis / Q000187:drug effects* / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D000072233:Homer Scaffolding Proteins; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced* / Q000517:prevention & control* / Q000523:psychology; D018727:Muscarinic Antagonists; D018696:Neuroprotective Agents; D016133:Polymerase Chain Reaction; D011719:Pyrazines / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis / Q000235:genetics / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D002352:Carrier Proteins; D017362:Cyclic AMP Response Element-Binding Protein; D000072233:Homer Scaffolding Proteins; D018727:Muscarinic Antagonists; D018696:Neuroprotective Agents; D011719:Pyrazines; D012313:RNA; D012601:Scopolamine; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; C017953:tetramethylpyrazine
keywords: Memory; Scopolamine; Synapse; Tetramethylpyrazine