title: A quantitative model of population dynamics in malaria with drug treatment.
abstract: In this paper we build a population dynamics of malaria including drug treatment. By taking into account both sensitive and resistant parasites, we want to see the effect of treatments on resistance phenomenon and prevent it from overspreading. Our main results include a new dynamics model, its mathematical properties which are found through analysis, the determination of unknown parameters with help of a data set for malaria from Burkina Faso and the numerical simulations of the fitted model. Based on these results, treatment strategies to reduce drug resistance can be elaborated.
authors.affiliation: Interdisciplinary Center for Scientific Computing, Im Neuenheimer Feld 368, 69120 , Heidelberg, Germany, an.lethithanh@iwr.uni-heidelberg.de.
authors.forename: Le Thi Thanh
authors.initials: le TT
authors.lastname: An
authors.forename: Willi
authors.initials: W
authors.lastname: Jäger
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002050:Burkina Faso / Q000453:epidemiology; D003198:Computer Simulation; D009033:Culicidae / Q000469:parasitology; D004351:Drug Resistance / Q000276:immunology; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology / Q000635:transmission; D018448:Models, Immunological; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000276:immunology; D011157:Population Dynamics
chemical_list: D000962:Antimalarials
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