title: Soluble interleukin-6 receptor is a prognostic marker for relapse-free survival in estrogen receptor-positive breast cancer.
abstract: Considering the protumorigenic roles of interleukin-6 (IL-6) transsignaling, we assessed the serum levels of IL-6, soluble interleukin-6 receptor (sIL-6R), and soluble glycoprotein 130 (sgp130) in 143 patients with breast cancer. Serum levels of IL-6 were elevated with advanced T and N stage. Serum levels of sIL-6R were lower in patients with estrogen receptor-positive cancer. The median values of IL-6 and sgp130 did not differ between patients with recurrence and those without recurrence. However, higher serum levels of sIL-6R at diagnosis were associated with significantly shorter relapse-free survival in patients with estrogen receptor-positive breast cancer.
authors.affiliation: Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Uijeongbu-si, Gyeonggi-do , Korea,1.
authors.forename: Hye Sung
authors.initials: HS
authors.lastname: Won
authors.forename: Young Ae
authors.initials: YA
authors.lastname: Kim
authors.forename: Jun Sang
authors.initials: JS
authors.lastname: Lee
authors.forename: Eun Kyoung
authors.initials: EK
authors.lastname: Jeon
authors.forename: Ho Jung
authors.initials: HJ
authors.lastname: An
authors.forename: Der Sheng
authors.initials: DS
authors.lastname: Sun
authors.forename: Yoon Ho
authors.initials: YH
authors.lastname: Ko
authors.forename: Jeong Soo
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood* / Q000378:metabolism; D001943:Breast Neoplasms / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D050822:Cytokine Receptor gp130 / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000378:metabolism; D019947:Receptors, Interleukin-6 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D015850:Interleukin-6; D011960:Receptors, Estrogen; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130