title: Childhood pheochromocytoma in a survivor of central primitive neuroectodermal tumor.
abstract: Pheochromocytoma and central nervous system primitive neuroectodermal tumor are both neural crest-derived tumors. The former is usually benign and develops mainly in adulthood and the latter brain tumor mainly occurs in childhood and has a poor prognosis. We report a case of a 15-year-old boy who developed pheochromocytoma after more than 10 years of complete remission of central primitive neuroectodermal tumor. Thus far, there have been no reports of childhood cancer survivors who developed pheochromocytoma. This quite rare occurrence of two tumors in a single patient may imply some unidentified linkage or common genetic background.
authors.affiliation: Department of Pediatrics, Osaka City General Hospital, Osaka, Japan. nakanolp@gmail.com
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Nakano
authors.forename: Rika
authors.initials: R
authors.lastname: Fujimaru
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ishii
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sako
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamada
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000628:therapy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary; D018242:Neuroectodermal Tumors, Primitive; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed
keywords: hypertension; neural crest; pheochromocytoma; primitive neuroectodermal tumor