title: Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach.
abstract: Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, CB #3290, Caudill Labs, Chapel Hill, NC, 27599.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Moga
authors.forename: Lissett R
authors.initials: LR
authors.lastname: Bickford
authors.forename: Robert D
authors.initials: RD
authors.lastname: Geil
authors.forename: Stuart S
authors.initials: SS
authors.lastname: Dunn
authors.forename: Ashish A
authors.initials: AA
authors.lastname: Pandya
authors.forename: Yapei
authors.initials: Y
authors.lastname: Wang
authors.forename: John H
authors.initials: JH
authors.lastname: Fain
authors.forename: Christine F
authors.initials: CF
authors.lastname: Archuleta
authors.forename: Adrian T
authors.initials: AT
authors.lastname: O'Neill
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Desimone
keywords: PRINT; drug delivery; microneedles; microprojections; soft lithography
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