title: ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis.
abstract: Arabidopsis SOG1 (suppressor of gamma response 1) is a plant-specific transcription factor that governs the DNA damage response. Here we report that SOG1 is phosphorylated in response to DNA damage, and that this phosphorylation is mediated by the sensor kinase ataxia telangiectasia mutated (ATM). We show that SOG1 phosphorylation is crucial for the response to DNA damage, including transcriptional induction of downstream genes, transient arrest of cell division and programmed cell death. Although the amino-acid sequences of SOG1 and the mammalian tumour suppressor p53 show no similarity, this study demonstrates that ATM-mediated phosphorylation of a transcription factor has a pivotal role in the DNA damage response in both plants and mammals.
authors.affiliation: 1] Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Nara 630-0192, [2] Department of Bioresource and Environmental Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kyoto 603-8555.
authors.forename: Kaoru O
authors.initials: KO
authors.lastname: Yoshiyama
authors.forename: Junya
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Ogita
authors.forename: Minako
authors.initials: M
authors.lastname: Ueda
authors.forename: Seisuke
authors.initials: S
authors.lastname: Kimura
authors.forename: Hisaji
authors.initials: H
authors.lastname: Maki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Umeda
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D018506:Gene Expression Regulation, Plant; D008969:Molecular Sequence Data; D010766:Phosphorylation; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: C576589:ATM protein, Arabidopsis; D029681:Arabidopsis Proteins; C561308:SOG1 protein, Arabidopsis; D014157:Transcription Factors; D064007:Ataxia Telangiectasia Mutated Proteins
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