title: BMP-4 polymorphisms in the susceptibility of cervical spondylotic myelopathy and its outcome after anterior cervical corpectomy and fusion.
abstract: BACKGROUND
  To investigate the association between single nucleotide polymorphisms (SNPs) of bone morphogenic proteins-4 (BMP-4) gene and the susceptibility of cervical spondylotic myelopathy (CSM) and its outcome after surgical treatment.
  
  
  METHODS
  A total of 499 patients with CSM and 602 healthy volunteers were recruited. 425 CSM patients received anterior cervical corpectomy and fusion (ACF) and were follow-up until 12 months. The SNPs of BMP-4 were determined.
  
  
  RESULTS
  For 6007C > T polymorphism, the cases had a significant lower prevalence of TT genotype than controls. With the CC genotype as reference, the TT genotype carriages significantly influence the CSM risk. The T allele carriage represented a higher risk for CSM as well. The TT of 6007C>T polymorphisms is also associated with higher chance to gain improvement from ACF surgery. The T allele carriage of 6007C>T had markedly higher chance to have a better post-operative outcome compared with C allele carriage. The genotype and allele distributions of -5826G>A polymorphism did not show positive association with risk and outcome of CSM in this study.
  
  
  CONCLUSIONS
  BMP-4 genetic polymorphisms may be used as a molecular marker for the CSM susceptibility and its postoperative outcome in those underwent surgical treatment.
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Post Street, Nangang District, Harbin 150001, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Cao
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Guijun
authors.initials: G
authors.lastname: Yao
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Bi
mesh_terms: D000328:Adult; D000483:Alleles; D055415:Bone Morphogenetic Protein 4 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013118:Spinal Cord Diseases / Q000235:genetics* / Q000601:surgery
chemical_list: D055415:Bone Morphogenetic Protein 4