title: Study of 1,3,5-triazine-based catalytic amide-forming reactions: effect of solvents and basicity of reactants.
abstract: Effect of the basic property of reactants (tertiary amine catalysts, a substrate amine, and acid neutralizers) on catalytic dehydrocondensation between a carboxylic acid and an amine by using 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) was studied. The reaction yield was affected by the acid-base equilibrium among reactants. In dichloromethane, a representative aprotic solvent, a strongly basic catalyst gave amides in higher yields than weakly basic catalysts, regardless of the basicity of the acid neutralizer, which is called the proton capture agent (PCA). In contrast, in protic solvents, such as methanol or aqueous methanol, weakly basic catalysts gave amides in somewhat better yields than the strongly basic catalysts. In general, PCAs with weakly basic properties are favorable, because those with strongly basic properties tend to give byproducts arising from the reaction between CDMT and the substrate amine.
authors.affiliation: Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920–1192, Japan. kunisima@p.kanazawa-u.ac.jp
authors.forename: Munetaka
authors.initials: M
authors.lastname: Kunishima
authors.forename: Masanori
authors.initials: M
authors.lastname: Kitamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakakura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Moriya
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Hioki
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D008752:Methylene Chloride / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D014227:Triazines / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D002264:Carboxylic Acids; D012997:Solvents; D014227:Triazines; D008752:Methylene Chloride