title: Cortical sources of resting state electroencephalographic alpha rhythms deteriorate across time in subjects with amnesic mild cognitive impairment.
abstract: Cortical sources of resting state electroencephalographic (EEG) rhythms are abnormal in subjects with mild cognitive impairment (MCI). Here, we tested the hypothesis that these sources in amnesic MCI subjects further deteriorate over 1 year. To this aim, the resting state eyes-closed EEG data were recorded in 54 MCI subjects at baseline (Mini Mental State Examination I = 26.9; standard error [SE], 0.2) and at approximately 1-year follow-up (13.8 months; SE, 0.5; Mini Mental State Examination II = 25.8; SE, 0.2). As a control, EEG recordings were also performed in 45 normal elderly and in 50 mild Alzheimer's disease subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), and beta2 (20-30 Hz). Cortical EEG sources were estimated using low-resolution brain electromagnetic tomography. Compared with the normal elderly and mild Alzheimer's disease subjects, the MCI subjects were characterized by an intermediate power of posterior alpha1 sources. In the MCI subjects, the follow-up EEG recordings showed a decreased power of posterior alpha1 and alpha2 sources. These results suggest that the resting state EEG alpha sources were sensitive-at least at the group level-to the cognitive decline occurring in the amnesic MCI group over 1 year, and might represent cost-effective, noninvasive and widely available markers to follow amnesic MCI populations in large clinical trials.
authors.affiliation: Department of Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy. Electronic address: claudio.babiloni@uniroma1.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.forename: Claudio
authors.initials: C
authors.lastname: Del Percio
authors.forename: Roberta
authors.initials: R
authors.lastname: Lizio
authors.forename: Nicola
authors.initials: N
authors.lastname: Marzano
authors.forename: Francesco
authors.initials: F
authors.lastname: Infarinato
authors.forename: Andrea
authors.initials: A
authors.lastname: Soricelli
authors.forename: Elena
authors.initials: E
authors.lastname: Salvatore
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferri
authors.forename: Cinzia
authors.initials: C
authors.lastname: Bonforte
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Tedeschi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Montella
authors.forename: Annalisa
authors.initials: A
authors.lastname: Baglieri
authors.forename: Guido
authors.initials: G
authors.lastname: Rodriguez
authors.forename: Francesco
authors.initials: F
authors.lastname: Famà
authors.forename: Flavio
authors.initials: F
authors.lastname: Nobili
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vernieri
authors.forename: Francesca
authors.initials: F
authors.lastname: Ursini
authors.forename: Ciro
authors.initials: C
authors.lastname: Mundi
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Frisoni
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Rossini
mesh_terms: D000368:Aged; D000513:Alpha Rhythm; D002540:Cerebral Cortex / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012146:Rest / Q000502:physiology*; D013997:Time Factors
keywords: Disease tracking; Electroencephalography (EEG); Low resolution brain electromagnetic tomography (LORETA); Mild cognitive impairment (MCI)