title: Effect of nucleic acid amplification testing on population-based incidence rates of Clostridium difficile infection.
abstract: Nucleic acid amplification testing (NAAT) is increasingly being adopted for diagnosis of Clostridium difficile infection (CDI). Data from 3 states conducting population-based CDI surveillance showed increases ranging from 43% to 67% in CDI incidence attributable to changing from toxin enzyme immunoassays to NAAT. CDI surveillance requires adjustment for testing methods.
authors.affiliation: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention.
authors.forename: Carolyn V
authors.initials: CV
authors.lastname: Gould
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Edwards
authors.forename: Jessica
authors.initials: J
authors.lastname: Cohen
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Bamberg
authors.forename: Leigh Ann
authors.initials: LA
authors.lastname: Clark
authors.forename: Monica M
authors.initials: MM
authors.lastname: Farley
authors.forename: Helen
authors.initials: H
authors.lastname: Johnston
authors.forename: Joelle
authors.initials: J
authors.lastname: Nadle
authors.forename: Lisa
authors.initials: L
authors.lastname: Winston
authors.forename: Dale N
authors.initials: DN
authors.lastname: Gerding
authors.forename: L Clifford
authors.initials: LC
authors.lastname: McDonald
authors.forename: Fernanda C
authors.initials: FC
authors.lastname: Lessa
mesh_terms: D003015:Clostridium Infections / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D012680:Sensitivity and Specificity
keywords: Clostridium difficile; clinical laboratory techniques; incidence; nucleic acid amplification techniques; surveillance
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