title: Regulation of transient receptor potential channels by the phospholipase C pathway.
abstract: Transient Receptor Potential (TRP) channels were discovered while analyzing visual mutants in Drosophila. The protein encoded by the transient receptor potential (trp) gene is a Ca(2+) permeable cation channel activated downstream of the phospholipase C (PLC) pathway. While searching for homologs in other organisms, a surprisingly large number of mammalian TRP channels was cloned. The regulation of TRP channels is quite diverse, but many of them are either activated downstream of PLC, or modulated by it. This review will summarize the current knowledge on regulation of TRP channels by PLC, with special focus on TRPC-s, which can be considered as effectors of PLC and the heat- and capsaicin-sensitive TRPV1, which is modulated by the PLC pathway in a complex manner.
authors.affiliation: Rutgers, New Jersey Medical School, Newark, NJ, USA. Electronic address: rohacsti@njms.rutgers.edu.
authors.forename: Tibor
authors.initials: T
authors.lastname: Rohacs
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000378:metabolism*; D010738:Type C Phospholipases / Q000235:genetics / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D050051:Transient Receptor Potential Channels; C063169:trp protein, Drosophila; D010738:Type C Phospholipases; D002118:Calcium
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