title: Lysosomal exoglycosidases in nasal polyps.
abstract: BACKGROUND
  Nasal polyps are smooth outgrowths assuming a shape of grapes, formed from the nasal mucosa, limiting air flow by projecting into a lumen of a nasal cavity. Up to now the surgical resection is the best method of their treatment, but etiology and pathogenesis of the nasal polyps is not yet fully established.
  
  
  OBJECTIVE
  The aim of the study was the assessment of the selected lysosomal exoglycosidases activity in the nasal polyps. In this study the activity of β-galactosidase, α-mannosidase and α-fucosidase was determined in the tissue of the nasal polyps obtained from 40 patients (10F, 30M) and control tissues derived from mucosa of lower nasal conchas obtained during mucotomy from 20 patients (10F, 10M).
  
  
  RESULTS
  We observed significant lower values of GAL, FUC and tendency to decrease of MAN and GLU concentration in nasal polyps (P) in comparison to control healthy nasal mucosa (C). In nasal polyp tissue (P) no differences of GAL, MAN and FUC specific activity in comparison to control mucosa (C) were found.
  
  
  CONCLUSIONS
  Our research supports bioelectrical theory of the nasal polyps pathogenesis and directs attention at research on glycoconjugates and glycosidases of the nasal mucosa extracellular matrix.
authors.affiliation: Medical Institute, College of Computer Science and Business Administration, Lomza, Poland. sylwiachoj@o2.pl
authors.forename: Sylwia
authors.initials: S
authors.lastname: Chojnowska
authors.forename: Alina
authors.initials: A
authors.lastname: Minarowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Knaś
authors.forename: Anna
authors.initials: A
authors.lastname: Niemcunowicz-Janica
authors.forename: Paweł
authors.initials: P
authors.lastname: Kołodziejczyk
authors.forename: Beata
authors.initials: B
authors.lastname: Zalewska-Szajda
authors.forename: Alina
authors.initials: A
authors.lastname: Kępka
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Minarowski
authors.forename: Napoleon
authors.initials: N
authors.lastname: Waszkiewicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zwierz
authors.forename: Sławomir Dariusz
authors.initials: SD
authors.lastname: Szajda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005109:Extracellular Matrix / Q000201:enzymology; D005260:Female; D006801:Humans; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000201:enzymology* / Q000473:pathology; D009298:Nasal Polyps / Q000201:enzymology* / Q000473:pathology; D055815:Young Adult; D005644:alpha-L-Fucosidase / Q000378:metabolism*; D043323:alpha-Mannosidase / Q000378:metabolism*; D001616:beta-Galactosidase / Q000378:metabolism*
chemical_list: D001616:beta-Galactosidase; D043323:alpha-Mannosidase; D005644:alpha-L-Fucosidase
keywords: Lysosomal exoglycosidases; Nasal polyps; α-Fucosidase; α-Mannosidase; β-Galactosidase