title: Churg-Strauss syndrome associated with rapid deterioration of left ventricular diastolic dysfunction and conduction disturbance.
abstract: Cardiac involvement in Churg-Strauss syndrome (CSS) is a major cause of mortality. Here we report a case of a 75-year-old woman with eosinophilic endomyocarditis due to CSS. An electrocardiogram showed intraventricular conduction delay, and echocardiography showed an impaired relaxation pattern and biventricular apical thickening. Magnetic resonance imaging revealed subendocardial delayed enhancement with biventricular apical thrombi. Endomyocardial biopsy showed perivascular eosinophilic infiltration. Despite resolution of the hypereosinophilia after steroid therapy, her left ventricular (LV) diastolic function worsened into a restrictive pattern and she died with a ventricular escape rhythm on her 14th day in the hospital. This case is unusual in that there was rapid progression of the LV diastolic dysfunction and conduction disturbance due to CSS.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jung Yeon
authors.initials: JY
authors.lastname: Chin
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Yi
authors.forename: Ho-Joong
authors.initials: HJ
authors.lastname: Youn
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000628:therapy*; D001706:Biopsy; D053840:Brugada Syndrome; D000075224:Cardiac Conduction System Disease; D015267:Churg-Strauss Syndrome / Q000175:diagnosis* / Q000628:therapy*; D003937:Diagnosis, Differential; D004452:Echocardiography / Q000379:methods*; D017809:Fatal Outcome; D005260:Female; D006329:Heart Conduction System / Q000002:abnormalities*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009206:Myocardium / Q000473:pathology; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000628:therapy*
keywords: Churg-Strauss syndrome; cardiac conduction defect; left ventricular dysfunction