title: Adsorption, inhibition, and biotransformation of ciprofloxacin under aerobic conditions.
abstract: The adsorption, inhibition, and biotransformation of the fluoroquinolone antibiotic ciprofloxacin (CIP) under aerobic conditions were investigated in this study. The maximum adsorption capacity and the Langmuir constant were 37.9 mg CIP/g VSS and 37 L/g, respectively. A glucose-fed aerobic culture was inhibited by CIP at 10mg/L or higher and the degree of inhibition increased with increasing CIP concentration. However, the microbial activity recovered to some extent with prolonged incubation under a semi-continuous feeding mode. A low extent of CIP biotransformation was observed in an aerobic, glucose-fed culture derived from poultry litter extract. LC/UV/MS analysis of the biotransformation product showed that only the piperazine ring was oxidized, while the antibiotic quinolone part of CIP was intact.
authors.affiliation: Key Laboratory of Yangtze Water Environment of Ministry of Education, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai 200092, China.
authors.forename: Zhanguang
authors.initials: Z
authors.lastname: Liu
authors.forename: Peizhe
authors.initials: P
authors.lastname: Sun
authors.forename: Spyros G
authors.initials: SG
authors.lastname: Pavlostathis
authors.forename: Xuefei
authors.initials: X
authors.lastname: Zhou
authors.forename: Yalei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000327:Adsorption; D000332:Aerobiosis; D061249:Batch Cell Culture Techniques; D001673:Biodegradation, Environmental; D057919:Biological Oxygen Demand Analysis; D018533:Biomass; D001711:Biotransformation; D002245:Carbon Dioxide / Q000032:analysis; D002939:Ciprofloxacin / Q000302:isolation & purification* / Q000378:metabolism*; D010100:Oxygen / Q000032:analysis; D013696:Temperature; D014835:Volatilization
chemical_list: D002245:Carbon Dioxide; D002939:Ciprofloxacin; D010100:Oxygen
keywords: Adsorption; Aerobic biotransformation; Ciprofloxacin; Inhibition; Mineralization