title: Patterned high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus.
abstract: Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that requires coactivation of GABA(A)Rs and muscarinic acetylcholine receptors (mAChRs), and endocytosis of AMPARs. Thus, we disclose that a patterned high-frequency stimulation triggers GABAAR and mAChR-dependent LTD in the hippocampus.
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Zhu
authors.forename: L
authors.initials: L
authors.lastname: Jing
authors.forename: T-T
authors.initials: TT
authors.lastname: Duan
authors.forename: Q
authors.initials: Q
authors.lastname: Yuan
authors.forename: J
authors.initials: J
authors.lastname: Cao
authors.forename: Q-X
authors.initials: QX
authors.lastname: Zhou
authors.forename: L
authors.initials: L
authors.lastname: Xu
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D056547:CA1 Region, Hippocampal / Q000187:drug effects; D004558:Electric Stimulation; D055724:Electrophysiological Phenomena; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D018756:GABA Antagonists / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*
chemical_list: D001565:Benzoates; D018691:Excitatory Amino Acid Antagonists; D018756:GABA Antagonists; D011500:Protein Synthesis Inhibitors; D011950:Receptors, Cholinergic; D011963:Receptors, GABA-A; C079694:alpha-methyl-4-carboxyphenylglycine; D000841:Anisomycin; D015763:2-Amino-5-phosphonovalerate; D005998:Glycine
keywords: (RS)-α-methyl-4-carboxyphenylglycine; ACSF; ACh; Atrp; BIC; D-AP5; DMSO; GABA(A) receptors; HFS; IBI; LFS; LTD; LTP; MCPG; N-methyl-d-aspartic acid receptor; NMDAR; PHS; PTX; Scopo; Sti; TBS; acetylcholine; artificial cerebrospinal fluid; atropine; bicuculline; d-(−)-2-amino-5-phosphonopentanoic acid; dimethyl sulfoxide; fEPSPs; field excitatory postsynaptic potentials; high-frequency stimulation; hippocampal CA1; inter-burst interval; long-term depression; long-term potentiation; low-frequency stimulation; mACh receptors; mAChR; mGluR; metabotropic glutamate receptor; muscarinic acetylcholine receptor; patterned high-frequency stimulation; picrotoxin; scopolamine; stimulation; theta burst stimulation