title: Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Blvd. MC 210-41, Pasadena, CA 91125, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: McIntosh
authors.forename: Pedro S
authors.initials: PS
authors.lastname: Coelho
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Farwell
authors.forename: Z Jane
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Jared C
authors.initials: JC
authors.lastname: Lewis
authors.forename: Tristan R
authors.initials: TR
authors.lastname: Brown
authors.forename: Frances H
authors.initials: FH
authors.lastname: Arnold
mesh_terms: D000586:Amination; D055162:Biocatalysis; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D015202:Protein Engineering; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry / Q000378:metabolism*
chemical_list: D013449:Sulfonamides; C480101:beta-sultam; D003577:Cytochrome P-450 Enzyme System
keywords: CH activation; cytochromes; enzyme catalysis; protein engineering; synthetic biology
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