title: Cu-catalyzed asymmetric borylative cyclization of cyclohexadienone-containing 1,6-enynes.
abstract: The first Cu-catalyzed asymmetric borylative cyclization of cyclohexadienone-containing 1,6-enynes is achieved through a tandem process: selective β-borylation of propargylic ether and subsequent conjugate addition to cyclohexadienone. The reaction proceeds with excellent regioselectivity and enantioselectivity to afford an optically pure cis-hydrobenzofuran framework bearing alkenylboronate and enone substructures. Furthermore, the resulting bicyclic products could be converted to bridged and tricyclic ring structures. This method extends the realm of Cu-catalyzed asymmetric tandem reactions using bis(pinacolato)diboron (B2pin2).
authors.affiliation: Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fukui
authors.forename: Ping
authors.initials: P
authors.lastname: Tian
authors.forename: Zhi-Tao
authors.initials: ZT
authors.lastname: He
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Sun
authors.forename: Nuo-Yi
authors.initials: NY
authors.lastname: Wu
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Lin