title: [Pituitary functional recovery and hormone replacement therapy of patients with pituitary adenoma surgery].
abstract: OBJECTIVE
  To study the pituitary functional recovery of patients with pituitary adenoma surgery and to identify appropriate dosages of hormone replacement for those patients.
  
  
  METHODS
  Serum hormone levels of 187 patients with pituitary adenoma were detected before and after surgery.
  
  
  RESULTS
  The lowest serum hormone levels were detected on the 3rd day after surgery (P < 0.05). The hormone levels were partly recovered on the 30th day (P < 0.05) and continued to rise to a relatively high level on the 90th day and one year after surgery (P < 0.05). Patients with older ages were more likely to suffer from hypopituitarism and had less satisfying recovery (P < 0.05) than their younger counterparts. The dosages of Euthyrox and Prednisone that were needed for hormone replacement therapy reached a relatively stable level on the 90th day after surgery (P < 0.05).
  
  
  CONCLUSIONS
  Most patients with pituitary adenoma experienced hypopituitarism shortly after surgery, especially for the elderly who recovered more slowly. Low dosage of hormone replacement therapy based on their symptoms can help the patients reach a stable level of hormone within three months. As a result, the 90th day after surgery can be regarded as a cut-off time for measuring functional recovery of glandula pituitaria.
authors.affiliation: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Fu
authors.forename: Xin-Cheng
authors.initials: XC
authors.lastname: Xue
authors.forename: Pei-Zhi
authors.initials: PZ
authors.lastname: Zhou
authors.forename: Sen-Lin
authors.initials: SL
authors.lastname: Yin
authors.forename: Shu
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000236:Adenoma / Q000188:drug therapy* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010901:Pituitary Function Tests; D010902:Pituitary Gland / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D011184:Postoperative Period; D011241:Prednisone / Q000627:therapeutic use; D013974:Thyroxine / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D013974:Thyroxine; D011241:Prednisone