title: Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination model.
abstract: Cuprizone is a copper-chelating mitochondrial toxin that causes oligodendrocyte apoptosis and demyelination preferentially in the corpus callosum (CC) and the superior cerebellar peduncles, but not in the spinal cord (SC) of C57BL/6 mice. Here we aimed to determine the activities of copper-containing enzymes in correlation with the distribution of demyelination during exposure to cuprizone. The study revealed mitochondrial complex IV and superoxide dismutase activity alterations in both the pathology-affected CC and the non-affected SC. This observation raises the possibility that regionally different subcellular molecular interactions lead to the selective oligodendrocyte loss induced by the nonselective mitochondrial toxin, cuprizone.
authors.affiliation: Department of Neurology, University of Pécs, Hungary. Electronic address: acspeti@yahoo.com.
authors.forename: P
authors.initials: P
authors.lastname: Acs
authors.forename: M A
authors.initials: MA
authors.lastname: Selak
authors.forename: S
authors.initials: S
authors.lastname: Komoly
authors.forename: B
authors.initials: B
authors.lastname: Kalman
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002614:Chelating Agents / Q000633:toxicity*; D003337:Corpus Callosum / Q000187:drug effects / Q000201:enzymology; D003471:Cuprizone / Q000633:toxicity*; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D009836:Oligodendroglia / Q000187:drug effects* / Q000201:enzymology; D013116:Spinal Cord / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D013482:Superoxide Dismutase / Q000187:drug effects
chemical_list: D002614:Chelating Agents; D003471:Cuprizone; D013482:Superoxide Dismutase
keywords: Copper chelation; Cuprizone; Demyelination; Mitochondrial toxicity; Multiple sclerosis; Selective vulnerability