title: [Microsurgery for parasellar menningiomas and impact factors of recurrence].
abstract: OBJECTIVE
  To study the effect of microsurgery for parasellar menningiomas and to analyze the impact factors of recurrence.
  
  
  METHODS
  Clinical and follow-up data in a consecutive series of 134 patients with parasellar meningiomas were retrospectively analyzed.
  
  
  RESULTS
  A total of 109 patients (81.3%) had radical removal (Simpson grade I and II), and 116 patients were followed up for an average period of 81.6 months. The mean quality of life score (KPS) was 91.9, 90 patients regained full daily activity and 16 patients were able to take care of themselves. Oculomotor paralysis occurred in 7 patients, epilepsy in 8, and another 9 patients suffered hemispheral paralysis. Tumor recurred after the radical removal in 12 out of the 96 followup patients (12.5%). Tumor progressed after subtotal removal in 12 out of the 20 follow-up patients (60%). Tumor with cavernous sinus (CS) invasion had significantly higher risk of recurrence campared with non-CS invasion (P=0.043). The recurrence rate increased with the pathological grade (P<0.01).
  
  
  CONCLUSIONS
  Patients with parasellar meningiomas undergoing microsurgical resection may have a good long-term function outcome. For most patients, total removal by microsurgery is the first choice. Careful follow-up is needed if tumor invaded the CS and radiosurgery is proposed for WHO grade 1 and 2.
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Dun
authors.initials: D
authors.lastname: Yuan
authors.forename: Dingyang
authors.initials: D
authors.lastname: Liu
authors.forename: Xianrui
authors.initials: X
authors.lastname: Yuan
authors.forename: Weixi
authors.initials: W
authors.lastname: Jiang
authors.forename: Duanwu
authors.initials: D
authors.lastname: Luo
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Zefeng
authors.initials: Z
authors.lastname: Peng
authors.forename: Xiping
authors.initials: X
authors.lastname: Ding
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology / Q000601:surgery*; D008579:Meningioma / Q000473:pathology / Q000601:surgery*; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D019635:Neurosurgical Procedures / Q000379:methods; D011183:Postoperative Complications / Q000453:epidemiology; D012658:Sella Turcica; D055815:Young Adult