title: Dynamic regulation of ubiquitin-dependent cell cycle control.
abstract: Recent work revealed that cullin-RING ligases and the anaphase-promoting complex, two classes of ubiquitin ligases that are essential for cell division in all eukaryotes, are regulated in a highly dynamic manner. Here, we describe mechanisms that establish the dynamic regulation of these crucial ubiquitylation enzymes and discuss the functional consequences for cell division control.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, United States.
authors.forename: Allison
authors.initials: A
authors.lastname: Craney
authors.forename: Michael
authors.initials: M
authors.lastname: Rape
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome / Q000378:metabolism*; D000818:Animals; D059447:Cell Cycle Checkpoints; D002455:Cell Division; D044842:Cullin Proteins / Q000378:metabolism; D006801:Humans; D013379:Substrate Specificity; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D044842:Cullin Proteins; D025801:Ubiquitin; D064173:Anaphase-Promoting Complex-Cyclosome; D044767:Ubiquitin-Protein Ligases