title: Development of advanced antimicrobial and sterilized plasma polypropylene grafted muga (Antheraea assama) silk as suture biomaterial.
abstract: Surface modification of silk fibroin (SF) materials using environmentally friendly and non-hazardous process to tailor them for specific application as biomaterials has drawn a great deal of interest in the field of biomedical research. To further explore this area of research, in this report, polypropylene (PP) grafted muga (Antheraea assama) SF (PP-AASF) suture is developed using plasma treatment and plasma graft polymerization process. For this purpose, AASF is first sterilized in argon (Ar) plasma treatment followed by grafting PP onto its surface. AASF is a non-mulberry variety having superior qualities to mulberry SF and is still unexplored in the context of suture biomaterial. AASF, Ar plasma treated AASF (AASFAr) and PP-AASF are subjected to various characterization techniques for better comparison and the results are attempted to correlate with their observed properties. Excellent mechanical strength, hydrophobicity, antibacterial behavior, and remarkable wound healing activity of PP-AASF over AASF and AASFAr make it a promising candidate for application as sterilized suture biomaterial.
authors.affiliation: Physical Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati, 781035, India.
authors.forename: Dolly
authors.initials: D
authors.lastname: Gogoi
authors.forename: Arup Jyoti
authors.initials: AJ
authors.lastname: Choudhury
authors.forename: Joyanti
authors.initials: J
authors.lastname: Chutia
authors.forename: Arup Ratan
authors.initials: AR
authors.lastname: Pal
authors.forename: Mojibur
authors.initials: M
authors.lastname: Khan
authors.forename: Manash
authors.initials: M
authors.lastname: Choudhury
authors.forename: Pallabi
authors.initials: P
authors.lastname: Pathak
authors.forename: Gouranga
authors.initials: G
authors.lastname: Das
authors.forename: Dinkar S
authors.initials: DS
authors.lastname: Patil
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology*; D012831:Bombyx; D003460:Crystallization; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D008297:Male; D008422:Materials Testing; D055595:Mechanical Phenomena; D008826:Microbial Sensitivity Tests; D058626:Plasma Gases / Q000737:chemistry*; D011126:Polypropylenes / Q000494:pharmacology*; D011817:Rabbits; D047011:Silk / Q000494:pharmacology*; D013059:Spectrum Analysis, Raman; D013242:Sterilization; D013537:Sutures; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D058626:Plasma Gases; D011126:Polypropylenes; D047011:Silk
keywords: Silk suture; antibacterial; histopathology; plasma graft polymerization; sterilization