title: Three-dimensional anterior segment imaging in patients with type 1 Boston Keratoprosthesis with switchable full depth range swept source optical coherence tomography.
abstract: A high-speed (100 kHz A-scans/s) complex conjugate resolved 1 μm swept source optical coherence tomography (SS-OCT) system using coherence revival of the light source is suitable for dense three-dimensional (3-D) imaging of the anterior segment. The short acquisition time helps to minimize the influence of motion artifacts. The extended depth range of the SS-OCT system allows topographic analysis of clinically relevant images of the entire depth of the anterior segment of the eye. Patients with the type 1 Boston Keratoprosthesis (KPro) require evaluation of the full anterior segment depth. Current commercially available OCT systems are not suitable for this application due to limited acquisition speed, resolution, and axial imaging range. Moreover, most commonly used research grade and some clinical OCT systems implement a commercially available SS (Axsun) that offers only 3.7 mm imaging range (in air) in its standard configuration. We describe implementation of a common swept laser with built-in k-clock to allow phase stable imaging in both low range and high range, 3.7 and 11.5 mm in air, respectively, without the need to build an external MZI k-clock. As a result, 3-D morphology of the KPro position with respect to the surrounding tissue could be investigated in vivo both at high resolution and with large depth range to achieve noninvasive and precise evaluation of success of the surgical procedure.
authors.affiliation: University of California Davis, Vision Science and Advanced Retinal Imaging Laboratory (VSRI), Sacramento, California 95817, USA.
authors.forename: Raju
authors.initials: R
authors.lastname: Poddar
authors.forename: Poddar
authors.initials: P
authors.lastname: Raju
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Cortés
authors.forename: John S
authors.initials: JS
authors.lastname: Werner
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mannis
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Zawadzki
mesh_terms: D000869:Anterior Eye Segment / Q000473:pathology* / Q000601:surgery*; D003316:Corneal Diseases / Q000473:pathology* / Q000601:surgery*; D016039:Corneal Transplantation / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005137:Eye, Artificial; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D007834:Lasers; D019721:Ophthalmoscopes; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation*; D016896:Treatment Outcome
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