title: Takotsubo cardiomyopathy after anti-influenza vaccination: catecholaminergic effects of immune system.
abstract: Takotsubo cardiomyopathy (TTC) is a well-known condition, which leads to sudden transient regional systolic dysfunction. It mostly affects aging women and is usually precipitated by emotional or physical stress. Despite the tremendous amount of literature on TTC, cardiac sympathetic hyperactivity is the only thing known to be associated with pathogenesis. In our case, an elderly woman presented with an acute episode of TTC 24 hours after anti-influenza vaccination without any obvious stressor for sudden rise in the catecholamine level. Sudden postvaccination change in the cardiac sympathetic discharge is the most likely precipitant of TTC in this case.
authors.affiliation: Department of Cardiology, Queen Elizabeth Hospital, Woodville South, SA, Australia. Electronic address: kjaulakh@gmail.com.
authors.forename: Kuljit
authors.initials: K
authors.lastname: Singh
authors.forename: Tina
authors.initials: T
authors.lastname: Marinelli
authors.forename: John D
authors.initials: JD
authors.lastname: Horowitz
mesh_terms: D000369:Aged, 80 and over; D004452:Echocardiography; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology; D008676:Metanephrine / Q000097:blood / Q000502:physiology; D009647:Normetanephrine / Q000097:blood / Q000502:physiology; D054549:Takotsubo Cardiomyopathy / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology
chemical_list: D007252:Influenza Vaccines; D009647:Normetanephrine; D008676:Metanephrine