title: [The progression of applying transgenic mice as an animal model of high myopia].
abstract: Gene engineering technology provides new methods for medical research. The application of transgenic animals and knock out animals makes it possible to study the biological characteristics of genes associated with some human diseases in vivo. Transgenic mice were first achieved in the early 1980s, while they were used extensively in the field of ophthalmology doing some research a few years later after that. Therefore, it can possibly be a new path to investigate the pathogenesis by establishing transgenic mouse model of candidate gene of high myopia.
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China.
authors.forename: Yan-zheng
authors.initials: YZ
authors.lastname: Song
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Zhao
authors.forename: Feng-ju
authors.initials: FJ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D008822:Mice, Transgenic; D009216:Myopia