title: The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling.
abstract: In urine specimens that were collected from pregnant women in a large cohort, 24% contained more than 10 ng/ml of total bisphenol A (BPA), suggesting external contamination. Therefore, we conducted an investigation of the source(s) of extraneous BPA in the specimens. We found that under the conditions used to collect urine specimens in the epidemiologic study, contamination with BPA occurred, and by two separate mechanisms.
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NIH/DHHS/USA, PO Box 12233, MD A3-05, NC 27709, USA. Electronic address: Longnec1@niehs.nih.gov.
authors.forename: M P
authors.initials: MP
authors.lastname: Longnecker
authors.forename: K
authors.initials: K
authors.lastname: Harbak
authors.forename: G E
authors.initials: GE
authors.lastname: Kissling
authors.forename: J A
authors.initials: JA
authors.lastname: Hoppin
authors.forename: M
authors.initials: M
authors.lastname: Eggesbo
authors.forename: T A
authors.initials: TA
authors.lastname: Jusko
authors.forename: J
authors.initials: J
authors.lastname: Eide
authors.forename: H M
authors.initials: HM
authors.lastname: Koch
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000652:urine*; D005260:Female; D006801:Humans; D010636:Phenols / Q000652:urine*; D011247:Pregnancy; D013048:Specimen Handling; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: BPA; Bisphenol A; Contamination; LOD; LOQ; MoBa; Norwegian Mother and Child Cohort Study; QC; SD; Urine specimen collection; bisphenol A; limit of detection; limit of quantitation; quality control; standard deviation
references.citation: Environ Health Perspect. 2013 Mar;121(3):283-6
references.pmid: 23458838
references.citation: Anal Bioanal Chem. 2011 Jan;399(3):1071-9
references.pmid: 21058032
references.citation: Int J Epidemiol. 2006 Oct;35(5):1146-50
references.pmid: 16926217
references.citation: Eur J Epidemiol. 2006;21(8):619-25
references.pmid: 17031521
references.citation: Anal Bioanal Chem. 2005 Oct;383(4):638-44
references.pmid: 16132150
references.citation: J Expo Sci Environ Epidemiol. 2012 Nov;22(6):610-6
references.pmid: 22617719
references.citation: J Expo Sci Environ Epidemiol. 2006 Jan;16(1):39-48
references.pmid: 16007114
references.citation: Environ Health Perspect. 2008 Jan;116(1):39-44
references.pmid: 18197297
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jan 25;784(1):169-82
references.pmid: 12504195
references.citation: J Expo Sci Environ Epidemiol. 2007 Sep;17(6):567-72
references.pmid: 17410114
references.citation: J Anal Toxicol. 2010 Jul-Aug;34(6):293-303
references.pmid: 20663281
references.citation: Environ Res. 2011 Aug;111(6):761-4
references.pmid: 21684541
references.citation: Int J Hyg Environ Health. 2009 Sep;212(5):481-91
references.pmid: 19394271
references.citation: Rapid Commun Mass Spectrom. 2010 Oct 30;24(20):3011-20
references.pmid: 20872634