title: Quantitative analysis of subfoveal choroidal thickness using enhanced depth imaging optical coherence tomography in normal eyes.
abstract: To evaluate subfoveal choroidal thickness of normal eyes with the use of the enhanced depth imaging technique of optical coherence tomography (EDI-OCT) and correlation of choroidal thickness with patient age. A retrospective analysis of 123 healthy eyes was performed. Age, gender, refractive state and spheric equivalencies were noted. Subfoveal choroidal thickness was measured and noted manually by two independent observers. A total of 72 patients (123 eyes) were included in this study. The mean age of the patients was 47.47 (15-84). The mean spheric equivalent of the refractive error was -0.24 D. According to LogMAR, the mean visual acuity was -0.006. The mean subfoveal choroidal thickness was 280.23 μm (SD ± 81.15, range 124-527 μm). The choroidal thickness showed a negative correlation with age for the subfoveal location (p = 0.000(a)). Regression analysis showed that subfoveal choroidal thickness decreased 3.14 μm for each year of age. The regression formulation was choroidal thickness = 429 - 3.14 × age. When we compared eyes according to their spheric equivalencies, there was no statistically significant correlation between spheric equivalency and subfoveal choroidal thickness. (p = 0.14). In this study, we report choroidal thickness measurement among healthy eyes within the Turkish population to demonstrate that EDI-OCT imaging can give cross-sectional information regarding the choroid, thereby facilitating quantitative imaging.
authors.affiliation: Istanbul Education and Research Hospital, Istanbul, Turkey, sezino@hotmail.com.
authors.forename: Sezin
authors.initials: S
authors.lastname: Ozdogan Erkul
authors.forename: Ziya
authors.initials: Z
authors.lastname: Kapran
authors.forename: O Murat
authors.initials: OM
authors.lastname: Uyar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012044:Regression Analysis; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
references.citation: Ophthalmology. 2012 May;119(5):1017-23
references.pmid: 22281089
references.citation: Ophthalmic Surg Lasers Imaging. 2012 Jul 1;43(4):296-301
references.pmid: 22589335
references.citation: Ophthalmic Surg Lasers Imaging. 2012 Mar-Apr;43(2):109-14
references.pmid: 22320414
references.citation: Auton Neurosci. 2002 Apr 18;97(1):35-41
references.pmid: 12036184
references.citation: Ophthalmology. 2012 Dec;119(12):2572-8
references.pmid: 22921388
references.citation: Am J Ophthalmol. 2008 Oct;146(4):496-500
references.pmid: 18639219
references.citation: Retina. 2009 Nov-Dec;29(10):1469-73
references.pmid: 19898183
references.citation: Am J Ophthalmol. 2009 Apr;147(4):644-52
references.pmid: 19152869
references.citation: Invest Ophthalmol Vis Sci. 2012 Jan 25;53(1):261-6
references.pmid: 22167095
references.citation: J Glaucoma. 1997 Feb;6(1):23-32
references.pmid: 9075077
references.citation: Retina. 2011 Sep;31(8):1603-8
references.pmid: 21487334
references.citation: Invest Ophthalmol Vis Sci. 2011 Oct 31;52(11):8438-41
references.pmid: 21917938
references.citation: Am J Ophthalmol. 2009 May;147(5):811-5
references.pmid: 19232559
references.citation: Ophthalmology. 2013 Jan;120(1):175-80
references.pmid: 23009895
references.citation: Am J Ophthalmol. 2009 May;147(5):801-10
references.pmid: 19232561
references.citation: Retina. 2011 Feb;31(2):332-5
references.pmid: 20975620
references.citation: Am J Ophthalmol. 2009 Sep;148(3):445-50
references.pmid: 19541286
references.citation: Retina. 2011 Oct;31(9):1904-11
references.pmid: 21878855
references.citation: Invest Ophthalmol Vis Sci. 2011 Dec 20;52(13):9555-60
references.pmid: 22058342
references.citation: Retina. 2012 Nov-Dec;32(10):2061-9
references.pmid: 23095726
references.citation: Invest Ophthalmol Vis Sci. 2004 Mar;45(3):900-5
references.pmid: 14985308
references.citation: Curr Eye Res. 2001 Nov;23(5):352-6
references.pmid: 11910524
references.citation: Retina. 2012 Oct;32(9):1781-90
references.pmid: 22869022
references.citation: Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2173-6
references.pmid: 19892874
references.citation: Invest Ophthalmol Vis Sci. 1995 Mar;36(3):579-85
references.pmid: 7890489
references.citation: Ophthalmology. 2004 Jul;111(7):1344-51
references.pmid: 15234135