title: Epidermal growth factor, its receptor and transforming growth factor-β1 in the diagnosis of HCV-induced hepatocellular carcinoma.
abstract: In this article, we present a study on the levels of epidermal growth factor (EGF), its phosphorylated receptor (p-EGFR) and transforming growth factor-β1 (TGF-β1) in the sera of patients with hepatocellular carcinoma (HCC) and chronic hepatitis C (CHC) infection. The results reveal significant higher serum levels of EGF and TGF-β1 in patients with HCC compared to their level in patients with CHC infection and control subjects. The levels of p-EGFR in HCC and CHC patients show a highly significant difference between patients. Based on the best cutoff value of 914 pg/ml, EGF shows 63.3 % sensitivity and 87.5 % specificity for HCC patients where the area under the curve is 0.81. The p-EGFR shows sensitivity of 63.3 % and specificity of 100 % where the area under the curve is 0.87 for HCC patients based on the best cutoff value of 39 U/mg protein. The best cutoff value (370 pg/ml) for serum TGF-β1 displays sensitivity of 86.7 % and specificity of 100 %, where the area under the curve is 0.97 for HCC patients.
authors.affiliation: Oncology Diagnostic Unit, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Fatma
authors.initials: F
authors.lastname: Shehata
authors.forename: Nihad
authors.initials: N
authors.lastname: Abdel Monem
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sakr
authors.forename: Samar
authors.initials: S
authors.lastname: Kasem
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Balbaa
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000175:diagnosis* / Q000821:virology; D004815:Epidermal Growth Factor / Q000097:blood*; D066246:ErbB Receptors / Q000097:blood*; D016174:Hepacivirus; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000821:virology; D008875:Middle Aged; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D055815:Young Adult
chemical_list: D053773:Transforming Growth Factor beta1; D004815:Epidermal Growth Factor; C512478:EGFR protein, human; D066246:ErbB Receptors
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