title: Glucose metabolism during resting state reveals abnormal brain networks organization in the Alzheimer's disease and mild cognitive impairment.
abstract: This paper aims to study the abnormal patterns of brain glucose metabolism co-variations in Alzheimer disease (AD) and Mild Cognitive Impairment (MCI) patients compared to Normal healthy controls (NC) using the Alzheimer Disease Neuroimaging Initiative (ADNI) database. The local cerebral metabolic rate for glucose (CMRgl) in a set of 90 structures belonging to the AAL atlas was obtained from Fluro-Deoxyglucose Positron Emission Tomography data in resting state. It is assumed that brain regions whose CMRgl values are significantly correlated are functionally associated; therefore, when metabolism is altered in a single region, the alteration will affect the metabolism of other brain areas with which it interrelates. The glucose metabolism network (represented by the matrix of the CMRgl co-variations among all pairs of structures) was studied using the graph theory framework. The highest concurrent fluctuations in CMRgl were basically identified between homologous cortical regions in all groups. Significant differences in CMRgl co-variations in AD and MCI groups as compared to NC were found. The AD and MCI patients showed aberrant patterns in comparison to NC subjects, as detected by global and local network properties (global and local efficiency, clustering index, and others). MCI network's attributes showed an intermediate position between NC and AD, corroborating it as a transitional stage from normal aging to Alzheimer disease. Our study is an attempt at exploring the complex association between glucose metabolism, CMRgl covariations and the attributes of the brain network organization in AD and MCI.
authors.affiliation: Neurodiagnostic Department, Cuban Neuroscience Center, Havana, Cuba.
authors.forename: Gretel
authors.initials: G
authors.lastname: Sanabria-Diaz
authors.forename: Eduardo
authors.initials: E
authors.lastname: Martínez-Montes
authors.forename: Lester
authors.initials: L
authors.lastname: Melie-Garcia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000378:metabolism; D001931:Brain Mapping; D016022:Case-Control Studies; D002468:Cell Physiological Phenomena; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D059906:Neuroimaging; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: Alzheimers Dement. 2010 Jan;6(1):54-62
references.pmid: 20129319
references.citation: J Neurosci. 2010 Dec 15;30(50):16876-85
references.pmid: 21159959
references.citation: Neuron. 2012 Mar 22;73(6):1216-27
references.pmid: 22445348
references.citation: Psychiatry Res. 2008 Nov 30;164(2):143-53
references.pmid: 18930634
references.citation: Neurobiol Aging. 2012 Nov;33(11):2533-50
references.pmid: 22365486
references.citation: Nature. 1998 Jun 4;393(6684):440-2
references.pmid: 9623998
references.citation: J Cereb Blood Flow Metab. 1984 Dec;4(4):484-99
references.pmid: 6501442
references.citation: Neuroimage. 2003 Nov;20(3):1894-8
references.pmid: 14642499
references.citation: Brain. 2009 Jan;132(Pt 1):213-24
references.pmid: 18952674
references.citation: Neuroimage. 2012 Feb 1;59(3):2196-207
references.pmid: 22008374
references.citation: J Nucl Med. 2008 Mar;49(3):390-8
references.pmid: 18287270
references.citation: Neurobiol Aging. 2013 Aug;34(8):2014-22
references.pmid: 23561509
references.citation: Neuroimage. 2006 Apr 1;30(2):436-43
references.pmid: 16300968
references.citation: Brain. 2009 Dec;132(Pt 12):3366-79
references.pmid: 19439423
references.citation: Neuroimage. 2002 Apr;15(4):870-8
references.pmid: 11906227
references.citation: Science. 2002 May 3;296(5569):910-3
references.pmid: 11988575
references.citation: IEEE Trans Med Imaging. 1998 Feb;17(1):87-97
references.pmid: 9617910
references.citation: J Neurosci. 2003 Apr 15;23(8):3295-301
references.pmid: 12716936
references.citation: BMC Neurosci. 2009 Aug 21;10:101
references.pmid: 19698093
references.citation: Neuroimage. 2002 Sep;17(1):302-16
references.pmid: 12482085
references.citation: Neuron. 2012 Mar 22;73(6):1204-15
references.pmid: 22445347
references.citation: Neuroimage. 2010 Jun;51(2):654-64
references.pmid: 20202480
references.citation: J Neurosci. 2005 Aug 24;25(34):7709-17
references.pmid: 16120771
references.citation: PLoS One. 2012;7(2):e31302
references.pmid: 22312444
references.citation: Dementia. 1993 Mar-Apr;4(2):94-101
references.pmid: 8358518
references.citation: Neuroimage. 2013 Jan 1;64:173-84
references.pmid: 22975159
references.citation: Neuroscientist. 2006 Dec;12(6):512-23
references.pmid: 17079517
references.citation: Neuroimage. 2007 Oct 1;37(4):1083-90; discussion 1097-9
references.pmid: 17719799
references.citation: Ann N Y Acad Sci. 2009 Jul;1170:736-44
references.pmid: 19686221
references.citation: J Nucl Med. 2000 Jul;41(7):1155-62
references.pmid: 10914904
references.citation: J Neurosci. 2003 Feb 1;23(3):986-93
references.pmid: 12574428
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: Neuroimage. 2010 May 1;50(4):1497-510
references.pmid: 20083210
references.citation: Hum Brain Mapp. 2005 Dec;26(4):231-9
references.pmid: 15954139
references.citation: Neurobiol Aging. 2012 Aug;33(8):1564-78
references.pmid: 21813210
references.citation: Eur J Nucl Med Mol Imaging. 2009 May;36(5):811-22
references.pmid: 19142633
references.citation: Brain. 1988 Dec;111 ( Pt 6):1425-39
references.pmid: 3208064
references.citation: Alzheimers Dement. 2005 Jul;1(1):55-66
references.pmid: 17476317
references.citation: Brain Connect. 2012;2(5):275-83
references.pmid: 23025619
references.citation: Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18760-5
references.pmid: 18003904
references.citation: Front Comput Neurosci. 2011 Feb 08;5:5
references.pmid: 21369354
references.citation: PLoS Biol. 2008 Jul 1;6(7):e159
references.pmid: 18597554
references.citation: Neurobiol Aging. 2013 Aug;34(8):2023-36
references.pmid: 23541878
references.citation: J Neurosci. 2009 Feb 11;29(6):1860-73
references.pmid: 19211893
references.citation: Biomark Med. 2010 Feb;4(1):3-14
references.pmid: 20383319
references.citation: Zhongguo Yi Liao Qi Xie Za Zhi. 2011 May;35(3):164-8
references.pmid: 21954571
references.citation: Neuroimage. 2011 Apr 1;55(3):1132-46
references.pmid: 21194570
references.citation: J Cereb Blood Flow Metab. 2006 Sep;26(9):1213-21
references.pmid: 16525414
references.citation: Neuroimage. 2012 Mar;60(1):221-9
references.pmid: 22236449
references.citation: J Magn Reson Imaging. 2008 Apr;27(4):685-91
references.pmid: 18302232
references.citation: Neurology. 1996 Mar;46(3):692-700
references.pmid: 8618669
references.citation: Neurobiol Aging. 2012 May;33(5):899-913
references.pmid: 20724031
references.citation: Hum Brain Mapp. 2012 Nov;33(11):2535-49
references.pmid: 21922601
references.citation: Brain Res. 1987 Mar 31;407(2):294-306
references.pmid: 3494486
references.citation: Alzheimers Dement. 2012 Feb;8(1 Suppl):S1-68
references.pmid: 22047634
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53
references.pmid: 16945915
references.citation: JAMA. 2001 Nov 7;286(17):2120-7
references.pmid: 11694153
references.citation: Neurology. 2007 Aug 28;69(9):871-7
references.pmid: 17724289
references.citation: J Neurosci. 2011 Nov 2;31(44):15775-86
references.pmid: 22049421
references.citation: J Alzheimers Dis. 2011;26 Suppl 3:321-9
references.pmid: 21971471
references.citation: J Neurosci. 2008 Jun 11;28(24):6174-81
references.pmid: 18550759
references.citation: Brain. 2010 Feb;133(Pt 2):529-39
references.pmid: 19914928
references.citation: Alzheimer Dis Assoc Disord. 2006 Jul-Sep;20(3 Suppl 2):S69-74
references.pmid: 16917199
references.citation: Alzheimer Dis Assoc Disord. 2007 Apr-Jun;21(2):77-84
references.pmid: 17545731
references.citation: Neuroimage. 2011 Jun 1;56(3):1382-5
references.pmid: 21338696
references.citation: Neurobiol Aging. 2009 Feb;30(2):186-97
references.pmid: 17651869
references.citation: Eur J Nucl Med Mol Imaging. 2005 Apr;32(4):486-510
references.pmid: 15747152
references.citation: Neuroimage. 2010 Mar;50(1):48-55
references.pmid: 20006713
references.citation: PLoS One. 2010 Nov 01;5(11):e13788
references.pmid: 21072180
references.citation: Eur J Nucl Med Mol Imaging. 2008 Sep;35(9):1681-91
references.pmid: 18491089
references.citation: Neurology. 1984 Jul;34(7):939-44
references.pmid: 6610841
references.citation: J Neurosci. 2006 Jan 4;26(1):63-72
references.pmid: 16399673
references.citation: Neuroimage. 2010 Apr 15;50(3):935-49
references.pmid: 20079441
references.citation: J Cereb Blood Flow Metab. 1984 Dec;4(4):500-6
references.pmid: 6238975
references.citation: Neurobiol Aging. 2012 Apr;33(4):831.e11-9
references.pmid: 21880397
references.citation: Neurology. 1999 Mar 23;52(5):958-65
references.pmid: 10102412
references.citation: Ann Neurol. 1997 Jul;42(1):85-94
references.pmid: 9225689
references.citation: Psychiatry Res. 2009 Jul 15;173(1):8-14
references.pmid: 19443186
references.citation: Hum Brain Mapp. 2012 Mar;33(3):552-68
references.pmid: 21391279
references.citation: Neuropsychol Rev. 2003 Jun;13(2):79-92
references.pmid: 12887040
references.citation: Neurobiol Aging. 2011 Jul;32(7):1207-18
references.pmid: 19660834
references.citation: J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):58-66
references.pmid: 20639384
references.citation: Hum Brain Mapp. 2007 Oct;28(10):967-78
references.pmid: 17133390
references.citation: Neuroimage. 2009 May 1;45(4):1107-16
references.pmid: 19349228
references.citation: Neuroimage. 1996 Dec;4(3 Pt 1):194-200
references.pmid: 9345509
references.citation: Neuroimage. 2009 Jul 15;46(4):981-8
references.pmid: 19303935
references.citation: PLoS Comput Biol. 2007 Feb 2;3(2):e17
references.pmid: 17274684
references.citation: Neurology. 2004 Dec 28;63(12):2332-40
references.pmid: 15623696
references.citation: Dementia. 1996 Sep-Oct;7(5):239-45
references.pmid: 8872413
references.citation: Alzheimers Dement. 2010 May;6(3):221-9
references.pmid: 20451870
references.citation: Am J Psychiatry. 2002 May;159(5):738-45
references.pmid: 11986126
references.citation: PLoS Comput Biol. 2010 Nov 18;6(11):e1001006
references.pmid: 21124954
references.citation: Arch Neurol. 2001 Dec;58(12):1985-92
references.pmid: 11735772
references.citation: PLoS One. 2011;6(7):e21976
references.pmid: 21818285
references.citation: Cereb Cortex. 2007 Oct;17(10):2407-19
references.pmid: 17204824
references.citation: Neuroimage. 2009 Jan 1;44(1):43-50
references.pmid: 18691659
references.citation: Trends Neurosci. 2009 Oct;32(10):548-57
references.pmid: 19765835
references.citation: Ann N Y Acad Sci. 2008 Mar;1124:1-38
references.pmid: 18400922
references.citation: Biochim Biophys Acta. 2012 Mar;1822(3):457-66
references.pmid: 21958592
references.citation: Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8
references.pmid: 12506194
references.citation: Neuroimage. 2012 Nov 1;63(2):936-46
references.pmid: 22510256
references.citation: J Comp Neurol. 1988 Oct 15;276(3):313-42
references.pmid: 3192766
references.citation: Neurology. 1993 Nov;43(11):2412-4
references.pmid: 8232972
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
references.pmid: 15070770
references.citation: Alzheimers Dement. 2011 May;7(3):263-9
references.pmid: 21514250
references.citation: J Cogn Neurosci. 2000 Jan;12(1):1-47
references.pmid: 10769304
references.citation: Adv Exp Med Biol. 1991;291:231-48
references.pmid: 1927686
references.citation: Schizophr Res. 2013 Jan;143(1):165-71
references.pmid: 23182443
references.citation: PLoS Comput Biol. 2008 Jun 27;4(6):e1000100
references.pmid: 18584043
references.citation: J Neurosci. 2008 Apr 30;28(18):4756-66
references.pmid: 18448652
references.citation: Neuroimage. 2003 Mar;18(3):675-84
references.pmid: 12667845
references.citation: PLoS One. 2011;6(7):e21570
references.pmid: 21829437
references.citation: Science. 2002 Oct 25;298(5594):824-7
references.pmid: 12399590
references.citation: Neuropsychologia. 2000;38(8):1157-69
references.pmid: 10838150
references.citation: Annu Rev Psychol. 2009;60:173-96
references.pmid: 19035823
references.citation: Phys Rev Lett. 2001 Nov 5;87(19):198701
references.pmid: 11690461
references.citation: Alzheimers Dement. 2011 May;7(3):280-92
references.pmid: 21514248