title: [Epidemiological study of cytopenia among benzene-exposed workers and its influential factors].
abstract: OBJECTIVE
  To evaluate the benzene exposure level and cytopenia among the benzene exposed workers in Shanghai, China and to analyze the influential factors for the health of benzene-exposed workers.
  
  
  METHODS
  A total of 3314 benzene-exposed workers, who were from 85 benzene-related enterprises selected by stratified random sampling based on enterprise sizes and industries, were included in the study. The time-weighted average (TWA) concentration of benzene in each workshop was measured by individual sampling and fixed point sampling, and the benzene exposure level in workshop was evaluated accordingly. The occupational health examination results and health status of benzene-exposed workers were collected.
  
  
  RESULTS
  The median of TW A concentrations of benzene was 0.3 mg/m3. The TWA concentrations measured at 7 ( 1.4%) of the 504 sampling points were above the safety limit. Of the 7 points, 3 were from large enterprises, 2 from medium enterprises, and 2 from small enterprises; 3 were from shipbuilding industry, 1 from chemical industry, and 3 from light industry. Of the 3314 benzene-exposed workers, 451 ( 13.6%) had cytopenia, including 339 males ( 339/2548, 13.3%) and 112 females ( 112/766, 14.6% ). There were significant differences in the incidence rates of leukopenia and neutropenia among the benzene-exposed workers of different sexes and ages (P<0.05); there were significant differences in the incidence rate of cytopenia among the benzene-exposed workers of different ages and working years ( P<0.05 ); there were significant differences in the incidence of neutropenia among the benzene exposed workers of different working years ( P<0.05).
  
  
  CONCLUSIONS
  Monitoring and intervention measures should be enhanced to protect the benzene-exposed workers in the large enterprises in shipbuilding industry and medium and private enterprises in chemical industry from occupational hazards.
authors.affiliation: Shanghai Municipal Center For Disease Control And Prevention, Shanghai, China.
authors.forename: Juan-juan
authors.initials: JJ
authors.lastname: Peng
authors.forename: Mei-xia
authors.initials: MX
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Guo
authors.forename: Ran
authors.initials: R
authors.lastname: Zhuang
authors.forename: Xian-dong
authors.initials: XD
authors.lastname: Jia
mesh_terms: D000293:Adolescent; D000328:Adult; D001554:Benzene / Q000633:toxicity*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010198:Pancytopenia / Q000139:chemically induced* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001554:Benzene