title: Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients.
abstract: BACKGROUND
  Helicobacter pylori infection is a basic risk factor for chronic gastritis, and gastric carcinoma. Based on some studies, the reason is binding of H. pylori to H and Le(b) antigens in gastric mucosa. However, some other findings have not determined any association between the infection and these antigens. Because of this controversy and the fact that H. pylori infection and gastric adenocarcinoma are common diseases in Iran, the assessment of the association of H. pylori infection with these blood groups could be valuable.
  
  
  METHODS
  In a cross sectional study on 135 adult dyspeptic patients in Mashhad, Iran, from 2009 to 2010, H. pylori infection was evaluated by using the Heliprobe (14)C-urea breath test and the ABO and Lewis blood group antigens were determined by the tube method. Association between the Lewis and ABO phenotypes with H. pylori infection were analysed by Fisher's exact test. A P ≤ 0.05 was considered to be significant.
  
  
  RESULTS
  68 (50.4%) patients were positive for H. pylori infection. The frequencies of the ABO, Lewis and secretion phenotypes were not significant in the infected and non-infected patients. We also did not find a significant association between Le(a) and Le(b) antigens and this infection.
  
  
  CONCLUSIONS
  We could not establish a significant association between the Lewis, ABO and secretion phenotypes with H. pylori infection. Diversity of sequences of blood group antigen b-binding adhesion (babA gene) of H. pylori may be a reason why our findings are different from other studies in other geographic areas.
authors.affiliation: Department of Nuclear Medicine, Nuclear Medicine Research Center, Mashhad, Iran ; Department of Hematopathology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Aryana
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Keramati
authors.forename: Seyed Rasoul
authors.initials: SR
authors.lastname: Zakavi
authors.forename: Mohammad Hadi
authors.initials: MH
authors.lastname: Sadeghian
authors.forename: Hedieh
authors.initials: H
authors.lastname: Akbari
keywords: ABO blood groups; Helicobacter pylori; Lewis blood group; gastritis; secretor blood group
references.citation: Dig Dis. 2010;28(4-5):604-8
references.pmid: 21088410
references.citation: Ann Nucl Med. 2008 Aug;22(7):611-6
references.pmid: 18756364
references.citation: Helicobacter. 2004 Aug;9(4):324-9
references.pmid: 15270746
references.citation: Eur Rev Med Pharmacol Sci. 2010 Apr;14(4):302-8
references.pmid: 20496539
references.citation: Helicobacter. 2006 Oct;11 Suppl 1:1-5
references.pmid: 16925604
references.citation: Z Gastroenterol. 2002 May;40(5):273-6
references.pmid: 12016560
references.citation: Sao Paulo Med J. 2002 Mar 7;120(2):55-8
references.pmid: 11994774
references.citation: Curr Opin Infect Dis. 2012 Jun;25(3):337-44
references.pmid: 22555448
references.citation: FEMS Immunol Med Microbiol. 1998 Apr;20(4):257-66
references.pmid: 9626930
references.citation: World J Gastroenterol. 2010 Jan 28;16(4):474-8
references.pmid: 20101774
references.citation: Braz J Med Biol Res. 2010 Jul;43(7):611-8
references.pmid: 20521012
references.citation: Clin Lab. 2010;56(3-4):137-42
references.pmid: 20476645
references.citation: Science. 2004 Jul 23;305(5683):519-22
references.pmid: 15273394
references.citation: Biosci Trends. 2010 Oct;4(5):249-53
references.pmid: 21068478
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16923-8
references.pmid: 15557006
references.citation: Gastroenterol Res Pract. 2011;2011:930941
references.pmid: 21760778
references.citation: Nat Rev Mol Cell Biol. 2001 Jun;2(6):457-66
references.pmid: 11389469
references.citation: Rev Gastroenterol Peru. 2008 Jul-Sep;28(3):258-66
references.pmid: 18958142
references.citation: Infect Immun. 2004 Jun;72(6):3429-35
references.pmid: 15155649
references.citation: J Biol Chem. 2011 Jul 15;286(28):25256-64
references.pmid: 21596743
references.citation: J Gastroenterol Hepatol. 2010 Mar;25(3):479-86
references.pmid: 20370726
references.citation: Helicobacter. 2002;7 Suppl 1:8-16
references.pmid: 12197904
references.citation: Arch Iran Med. 2009 Nov;12(6):576-83
references.pmid: 19877751
references.citation: Blood. 2010 Jun 10;115(23):4635-43
references.pmid: 20308598