title: Rhodococcus jostii porin A (RjpA) functions in cholate uptake.
abstract: RjpA in Rhodococcus jostii is the ortholog of a channel-forming porin, MspA. Deletion of rjpA delayed growth of R. jostii on cholate but not on cholesterol. Eventual growth on cholate involved increased expression of other porins, namely, RjpB, RjpC, and RjpD. Porins appear essential for the uptake of bile acids by mycolic acid bacteria.
authors.affiliation: Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Vijayakumar
authors.initials: V
authors.lastname: Somalinga
authors.forename: William W
authors.initials: WW
authors.lastname: Mohn
mesh_terms: D020355:Cholates / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D003470:Culture Media / Q000737:chemistry; D017353:Gene Deletion; D018272:Porins / Q000235:genetics / Q000378:metabolism*; D012240:Rhodococcus / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
chemical_list: D020355:Cholates; D003470:Culture Media; D018272:Porins; D002784:Cholesterol
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