title: Effects of curcumin on glucose metabolism in the brains of rats subjected to chronic unpredictable stress: a 18 F-FDG micro-PET study.
abstract: BACKGROUND
  Chronic unpredictable stress (CUS) can cause behavioral and physiological abnormalities that are important to the prediction of symptoms of depression that may be associated with cerebral glucose metabolic abnormalities. Curcumin showed potential antidepressant effects, but whether or not it can reverse cerebral functional abnormalities and so ameliorate depression remains unknown.
  
  
  METHODS
  To investigate the effects of curcumin on brain activity in CUS rats, rats were subjected to 3 weeks of CUS and then treated with curcumin orally at a dose of 40 mg/kg/day for one month. 18 F fluorodeoxyglucose (18 F-FDG)-micro positron emission tomography (micro-PET) neuroimaging was used to detect changes in cerebral metabolism. Body weight, sucrose preference, and open field tests were used to record depressive behaviors during CUS and after curcumin treatment.
  
  
  RESULTS
  Three weeks of CUS significantly decreased body weight, sucrose preference, sucrose consumption, total distance travelling, and the number of rearing events. It also induced metabolic alterations in several parts of the brain, showing increased glucose metabolism in the right hemisphere. After curcumin treatment for one month, sucrose preference, sucrose consumption, total distance travelling, and the number of rearing events returned to normal levels. Curcumin treatment also induced strong deactivation of the left primary auditory cortex and activation of amygdalohippocampal cortex.
  
  
  CONCLUSIONS
  Curcumin was found to ameliorate the abnormalities in the behavior and brain glucose metabolism caused by CUS, which may account for its antidepressive effects.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Lin
authors.forename: Ligen
authors.initials: L
authors.lastname: Shi
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Jinhui
authors.initials: J
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Hu
authors.forename: Chuantao
authors.initials: C
authors.lastname: Zuo
authors.forename: Weijun
authors.initials: W
authors.lastname: Tang
authors.forename: Yunrong
authors.initials: Y
authors.lastname: Lu
authors.forename: Aimin
authors.initials: A
authors.lastname: Bao
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism*; D001931:Brain Mapping; D003474:Curcumin / Q000494:pharmacology*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D000928:Antidepressive Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D003474:Curcumin; D005947:Glucose
references.citation: J Psychopharmacol. 2011 Oct;25(10):1329-36
references.pmid: 20829308
references.citation: Brain Res. 2006 Nov 29;1122(1):56-64
references.pmid: 17022948
references.citation: Pharmacol Biochem Behav. 2005 Sep;82(1):200-6
references.pmid: 16171853
references.citation: Neuropsychopharmacology. 2008 Dec;33(13):3221-5
references.pmid: 18463627
references.citation: Neuroscience. 2010 Aug 11;169(1):171-81
references.pmid: 20435098
references.citation: Hum Psychopharmacol. 2010 Jul;25(5):423-7
references.pmid: 20589921
references.citation: Neurosci Res. 2010 Oct;68(2):77-87
references.pmid: 20603163
references.citation: Ann N Y Acad Sci. 2003 Apr;985:420-44
references.pmid: 12724175
references.citation: Biol Psychiatry. 2008 Feb 15;63(4):369-76
references.pmid: 17888408
references.citation: Neuroimage. 2009 Feb 1;44(3):1074-80
references.pmid: 18952183
references.citation: Pharmacol Biochem Behav. 2009 Mar;92(1):39-43
references.pmid: 19000708
references.citation: Neurosci Lett. 2011 Apr 15;493(3):145-8
references.pmid: 21334417
references.citation: Psychiatr Clin North Am. 2012 Mar;35(1):51-71
references.pmid: 22370490
references.citation: J Neurosci Methods. 2003 Oct 30;129(2):105-13
references.pmid: 14511814
references.citation: Arch Gen Psychiatry. 1985 May;42(5):441-7
references.pmid: 3872649
references.citation: Psychopharmacology (Berl). 2008 Dec;201(3):435-42
references.pmid: 18766332
references.citation: Br J Psychiatry. 1993 Aug;163:155-65
references.pmid: 8075905
references.citation: J Nucl Med. 2006 Jun;47(6):999-1006
references.pmid: 16741310
references.citation: Indian J Pharm Sci. 2010 Mar;72(2):149-54
references.pmid: 20838516
references.citation: J Psychopharmacol. 2007 Mar;21(2):134-5
references.pmid: 17329288
references.citation: Neuro Endocrinol Lett. 2009 Mar;30(1):119-24
references.pmid: 19300390
references.citation: Arch Gen Psychiatry. 1994 Sep;51(9):677-86
references.pmid: 8080344
references.citation: Eur J Pharmacol. 2008 Jan 6;578(1):43-50
references.pmid: 17942093
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1785-93
references.pmid: 21741425
references.citation: Acta Pol Pharm. 2011 Sep-Oct;68(5):769-75
references.pmid: 21928724
references.citation: Neuropsychobiology. 2005;52(2):90-110
references.pmid: 16037678
references.citation: Biol Psychiatry. 2000 Oct 15;48(8):813-29
references.pmid: 11063977
references.citation: ScientificWorldJournal. 2009 Nov 01;9:1233-41
references.pmid: 19882093
references.citation: Biol Psychiatry. 2009 Nov 1;66(9):832-9
references.pmid: 19596122
references.citation: Otol Neurotol. 2003 May;24(3):409-17
references.pmid: 12806293
references.citation: Physiol Behav. 1983 Sep;31(3):353-60
references.pmid: 6635005
references.citation: Indian J Physiol Pharmacol. 2011 Jul-Sep;55(3):207-12
references.pmid: 22471226
references.citation: Neurosci Biobehav Rev. 1992 Winter;16(4):525-34
references.pmid: 1480349
references.citation: Neurosci Biobehav Rev. 2012 Oct;36(9):2085-117
references.pmid: 22776763
references.citation: Psychopharmacology (Berl). 2005 Jun;179(4):769-80
references.pmid: 15619113
references.citation: Biol Psychiatry. 2011 Jun 15;69(12):e43-54
references.pmid: 21111403
references.citation: Neurosci Biobehav Rev. 2009 Feb;33(2):171-80
references.pmid: 18703084
references.citation: Science. 2000 Apr 7;288(5463):39-40
references.pmid: 10766633