title: A severe case of rat lungworm disease in Hawa'i.
abstract: A 23-year-old man living on the island of Hawa'i developed a life threatening case of eosinophilic meningitis caused by infection with Angiostrongylus cantonensis (rat lungworm disease: RLWD). He was comatose for 3 months, incurring brain and nerve damage sufficiently extensive that he was not expected to recover. The case was complicated by secondary infections of methicillin-resistant Staphylococcus aureus, Clostridium difficile, and pneumonia, which resulted in an empyema requiring a thoracoscopy and decortication. He was treated with prednisone, mebendozal, and pain medication for RLWD, and antibiotics and antifungal medications for the secondary infections. The administration of herbal supplements was requested by the family and approved, and these were administered through a gastric tube. Less than a month after being declared in a persistent vegetative state the man was able to talk, eat, and had regained some muscle functions. After release from the hospital he continued the use of supplements and received treatments of intravenous vitamin therapy. Four years after onset of the illness he is able to ride a bicycle, is a part time student, plays guitar, and is fluent in two foreign languages. RLWD is an emerging tropical disease of growing importance in Hawa'i.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawa'i, Hilo, HI 96720, USA. kehauhowe@gmail.com
authors.forename: Kathleen
authors.initials: K
authors.lastname: Howe
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use; D017185:Angiostrongylus cantonensis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000969:Antinematodal Agents / Q000627:therapeutic use; D016360:Clostridioides difficile; D003128:Coma / Q000469:parasitology / Q000628:therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004761:Enterocolitis, Pseudomembranous / Q000150:complications / Q000188:drug therapy; D004802:Eosinophilia / Q000150:complications / Q000469:parasitology / Q000628:therapy*; D006254:Hawaii; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use; D008581:Meningitis / Q000150:complications / Q000469:parasitology / Q000628:therapy*; D055624:Methicillin-Resistant Staphylococcus aureus; D011241:Prednisone / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy; D017206:Strongylida Infections / Q000150:complications* / Q000628:therapy; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000969:Antinematodal Agents; D004365:Drugs, Chinese Herbal; D008463:Mebendazole; D011241:Prednisone
keywords: Angiostrongyliasis; Angiostrongylus cantonensis; Case report; Chinese medicine; Coma; Eosinophilic meningitis; Herbal supplements; Vitamin therapy
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