title: Pattern of mucocutaneous manifestations in human immunodeficiency virus-positive patients in North India.
abstract: BACKGROUND
  Mucocutaneous diseases are among the first-recognized clinical manifestations of acquired immune deficiency syndrome. They function as visual markers in assessing the progression of human immunodeficiency virus (HIV) infection. Given the relative ease of examination of skin, its evaluation remains an important tool in the diagnosis of HIV infection.
  
  
  OBJECTIVE
  To determine the pattern of mucocutaneous manifestations in HIV-positive patients and to correlate their presence with CD4 counts.
  
  
  METHODS
  This cross-sectional study included 352 HIV-infected patients seen at PGIMER, Chandigarh, India, over a period of 1 year. The patients were screened for mucocutaneous disorders by an experienced dermatologist. The patients were classified into different stages according to the World Health Organization clinical and immunological staging system.
  
  
  RESULTS
  The most prevalent infection was candidiasis, seen in 57 patients (16.2%). Prevalence of candidiasis, dermatophytosis, herpes simplex, herpes zoster, molluscum contagiosum (MC), seborrheic dermatitis, adverse drug reaction, nail pigmentation, xerosis and diffuse hair loss differed statistically according to the clinical stages of HIV infection. There was a statistically significant association between immunological stages of HIV infection and dermatophytosis.
  
  
  CONCLUSIONS
  Results of our study suggest that mucocutaneous findings occur throughout the course of HIV infection. Dermatoses like MC and dermatophytosis show an inverse relation with CD4 cell count, and these dermatoses can be used as a proxy indicator of advanced immunosuppression to start highly active anti-retroviral therapy in the absence of facilities to carry out CD4 cell count.
authors.affiliation: Department of Skin and Veneral Diseases, Ashwini Medical College Hospital, Solapur, Maharashtra, India.
authors.forename: Sachin D
authors.initials: SD
authors.lastname: Kore
authors.forename: Amrinder J
authors.initials: AJ
authors.lastname: Kanwar
authors.forename: Keshavamurthy
authors.initials: K
authors.lastname: Vinay
authors.forename: Ajay
authors.initials: A
authors.lastname: Wanchu
keywords: Acquired immune deficiency syndrome; CD4 count; India; human immunodeficiency virus; mucocutaneous manifestation of AIDS
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