title: [Deep brain stimulation. New target areas and new indications].
abstract: Many patients with neurological movement disorders and psychiatric diseases cannot yet be adequately treated with conventional methods. Deep brain stimulation represents an important extension of therapeutic options by which invasive electrodes are implanted in various subcortical brain areas in order to achieve an improvement in motor and psychiatric symptoms by high frequency stimulation. Up to 2012 approximately 100,000 patients had been treated with deep brain stimulation worldwide. The indications for deep brain stimulation were essentially already established indications, such as idiopathic Parkinson's syndrome, dystonia and tremors. The newer indications which include in particular psychiatric symptoms, such as depression, obsessive diseases, addiction and Tourette syndrome, are as yet limited to approximately 5 % of treated patients. An increasingly better understanding of the system physiology of neurological and psychiatric diseases has promoted the search for new target areas and indications for treatment by neuromodulation. This article gives an overview of the latest developments in the established and also the developing application areas of deep brain stimulation.
authors.affiliation: Neurologische Klinik und Poliklinik, Universitätsklinik Würzburg, Würzburg, Deutschland.
authors.forename: M M
authors.initials: MM
authors.lastname: Reich
authors.forename: A A
authors.initials: AA
authors.lastname: Kühn
authors.forename: J
authors.initials: J
authors.lastname: Volkmann
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods* / Q000639:trends*; D003937:Diagnosis, Differential; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis* / Q000209:etiology / Q000534:rehabilitation*; D019636:Neurodegenerative Diseases / Q000150:complications / Q000175:diagnosis* / Q000534:rehabilitation*
references.citation: Neurosurgery. 2012 Jan;70(1):66-9
references.pmid: 21768914
references.citation: J Neurol Neurosurg Psychiatry. 2011 Aug;82(8):899-904
references.pmid: 21285454
references.citation: Lancet. 1999 Feb 27;353(9154):724
references.pmid: 10073521
references.citation: Mov Disord. 2008 Jul 15;23(9):1289-92
references.pmid: 18512756
references.citation: N Engl J Med. 2010 Jun 3;362(22):2077-91
references.pmid: 20519680
references.citation: Acta Neurochir Suppl. 2007;97(Pt 2):207-14
references.pmid: 17691306
references.citation: J Neurosurg. 2006 Apr;104(4):506-12
references.pmid: 16619653
references.citation: Mov Disord. 2008;23 Suppl 2:S482-8
references.pmid: 18668620
references.citation: Neurology. 2011 Sep 27;77(13):1295-304
references.pmid: 21917777
references.citation: Nervenarzt. 2010 Jun;81(6):680-7
references.pmid: 20495777
references.citation: Neurosci Biobehav Rev. 2013 Jul;37(6):1178-85
references.pmid: 23041074
references.citation: Brain. 2007 Jun;130(Pt 6):1596-607
references.pmid: 17251240
references.citation: J Neurosurg. 2006 Apr;104(4):513-24
references.pmid: 16619654
references.citation: Neurosurgery. 2006 Feb;58(2):E383; discussion E383
references.pmid: 16462466
references.citation: Mov Disord. 2010 Jul 30;25(10):1350-6
references.pmid: 20544817
references.citation: N Engl J Med. 2013 Feb 14;368(7):610-22
references.pmid: 23406026
references.citation: Ann Neurol. 2010 Oct;68(4):521-34
references.pmid: 20687206
references.citation: Arch Gen Psychiatry. 2007 Feb;64(2):170-6
references.pmid: 17283284
references.citation: Neurology. 2012 Apr 3;78(14):1090-5
references.pmid: 22402859
references.citation: Brain. 2010 Jan;133(Pt 1):205-14
references.pmid: 19773356
references.citation: Lancet Neurol. 2013 Jan;12(1):37-44
references.pmid: 23168021
references.citation: Lancet Neurol. 2010 Jun;9(6):581-91
references.pmid: 20434403
references.citation: Eur J Neurosci. 2010 Oct;32(7):1128-34
references.pmid: 21039952
references.citation: Lancet. 2013 Apr 20;381(9875):1361-1370
references.pmid: 23473846
references.citation: J Clin Psychiatry. 2012 Nov;73(11):1434-8
references.pmid: 23218160
references.citation: J Neurosurg. 2007 Jul;107(1):29-36
references.pmid: 17639870
references.citation: Can J Neurol Sci. 2004 Aug;31(3):333-42
references.pmid: 15376477
references.citation: J Neural Transm (Vienna). 2011 Oct;118(10):1453-60
references.pmid: 21448675
references.citation: Biol Psychiatry. 2013 Jun 15;73(12):1204-12
references.pmid: 23562618
references.citation: Ann Neurol. 2013 Aug;74(2):223-31
references.pmid: 23613463
references.citation: Rev Neurol (Paris). 1970 Aug;123(2):89-100
references.pmid: 4932913
references.citation: N Engl J Med. 2006 Aug 31;355(9):896-908
references.pmid: 16943402
references.citation: Neurosurgery. 2011 Dec;69(6):1248-53; discussion 1254
references.pmid: 21725254
references.citation: J Neurol Neurosurg Psychiatry. 2011 Mar;82(3):272-7
references.pmid: 20974647
references.citation: Br J Neurosurg. 2007 Oct;21(5):504-9
references.pmid: 17922323
references.citation: Lancet Neurol. 2012 Dec;11(12):1029-38
references.pmid: 23123071
references.citation: J Neural Transm (Vienna). 2001;108(1):53-61
references.pmid: 11261746
references.citation: Cleve Clin J Med. 2010 Jul;77 Suppl 3:S77-80
references.pmid: 20622083
references.citation: Arch Neurol. 2009 Jun;66(6):781-5
references.pmid: 19506141
references.citation: Brain. 2010 Jan;133(Pt 1):215-24
references.pmid: 19846583
references.citation: Neurology. 2011 Mar 8;76(10):870-8
references.pmid: 21383323
references.citation: JAMA. 2009 Jan 7;301(1):63-73
references.pmid: 19126811
references.citation: Brain. 2012 May;135(Pt 5):1463-77
references.pmid: 22508959
references.citation: Arch Gen Psychiatry. 2012 Feb;69(2):150-8
references.pmid: 22213770
references.citation: J Neurol. 2011 Jun;258(6):1183-5
references.pmid: 21287187
references.citation: Neurology. 2009 Jul 7;73(1):53-8
references.pmid: 19564584
references.citation: Stereotact Funct Neurosurg. 2009;87(1):37-44
references.pmid: 19174619
references.citation: Eur J Neurol. 2012 May;19(5):764-8
references.pmid: 22248187
references.citation: J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):258-62
references.pmid: 22205676
references.citation: J Neurol Neurosurg Psychiatry. 2003 Oct;74(10):1387-91
references.pmid: 14570831
references.citation: Am J Psychiatry. 2011 May;168(5):502-10
references.pmid: 21285143
references.citation: Neuropsychopharmacology. 2012 Aug;37(9):1975-85
references.pmid: 22473055
references.citation: Brain. 2013 Jul;136(Pt 7):2098-108
references.pmid: 23757762
references.citation: Ann Neurol. 2004 Aug;56(2):290-4
references.pmid: 15293283
references.citation: Neurology. 2008 Jul 8;71(2):80-4
references.pmid: 18420482
references.citation: Epilepsia. 2010 May;51(5):899-908
references.pmid: 20331461