title: Efficacy of topiramate as add-on therapy in two different types of progressive myoclonic epilepsy.
abstract: The present article describes two unrelated cases of progressive myoclonic epilepsy (PME) of the Lafora's disease and Unverricht-Lundborg types who were treated with topiramate (TPM) as add-on therapy for their myoclonus. After the initiation of topiramate therapy both cases responded with marked decrease in myoclonic seizure frequency and improvement of quality of life. Topiramate appears to be a useful alternative agent in cases of PME and could be consider for adjunctive therapy.
authors.affiliation: Department of Neurology, Firat (Euphrates) University, Elazig, Turkey.
authors.forename: Caner Feyzi
authors.initials: CF
authors.lastname: Demir
authors.forename: Hasan Hüseyin
authors.initials: HH
authors.lastname: Ozdemir
authors.forename: Bülent
authors.initials: B
authors.lastname: Müngen
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D020191:Myoclonic Epilepsies, Progressive / Q000188:drug therapy*; D000077236:Topiramate; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose