title: Direct transformation of amides into α-amino phosphonates via a reductive phosphination process.
abstract: The first general method for the reductive phosphination of amides in one pot has been developed. The reactions described provide a novel access to α-amino phosphonates in good to excellent yields, cover a broad scope of substrates such as secondary and tertiary amides, and do not require a low temperature.
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Gao
authors.forename: Zhongbin
authors.initials: Z
authors.lastname: Huang
authors.forename: Rongqiang
authors.initials: R
authors.lastname: Zhuang
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Pengbo
authors.initials: P
authors.lastname: Zhang
authors.forename: Guo
authors.initials: G
authors.lastname: Tang
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000577:Amides / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000577:Amides; D063065:Organophosphonates; D009943:Organophosphorus Compounds