title: Photochemical and antimicrobial properties of silver nanoparticle-encapsulated chitosan functionalized with photoactive groups.
abstract: Chitosan was functionalized with 4-((E)-2-(3-hydroxynaphthalen-2-yl)diazen-1-yl)benzoic acid by the coupling of the hydroxyl functional groups of chitosan with carboxylic acid group of the dye by DCC coupling method. The silver nanoparticles were prepared by sol-gel method of nanoparticle synthesis. Silver nanoparticle-encapsulated functionalized chitosan was prepared by the phase transfer method. The products were characterized by FTIR, UV-Vis, fluorescence and NMR spectroscopic methods and by SEM and TEM analysis. The photochemical properties of silver nanoparticle-encapsulated chitosan functionalized with 4-((E)-2-(3-hydroxynaphthalen-2-yl)diazen-1-yl)benzoic acid was studied in detail. The light-fastening properties of the chromophoric system was enhanced when attached to chitosan, and it can be further improved by the encapsulation of silver nanoparticles. The antibacterial analysis of silver nanoparticle-encapsulated functionalized chitosan was carried out against Staphylococcus aureus and Escherichia coli and against fungal species such as Aspergillus flavus and Aspergillus terreus. This study showed that silver nanoparticles-encapsulated functionalized chitosan can be used for antibacterial and antifungal applications.
authors.affiliation: Research and Post Graduate Department of Chemistry, St. Thomas College, Palai, Mahatma Gandhi University, Arunapuram P.O., Kottayam, Kerala, 686574, India. majothomas@gmail.com
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Mathew
authors.forename: Sunny
authors.initials: S
authors.lastname: Kuriakose
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D001565:Benzoates / Q000737:chemistry; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D055668:Photochemical Processes; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001565:Benzoates; D012834:Silver; D048271:Chitosan
keywords: Antimicrobial activity; Chitosan; Photophysical studies; Silver nanoparticles