title: A noncovalent, fluoroalkyl coating monomer for phosphonate-covered nanoparticles.
abstract: Gadolinium-containing phosphonate-coated gold nanoparticles were prepared and then non-covalently coated with an amphiphilic fluorous monomer. The monomer spontaneously self-assembles into a non-covalent monolayer shell around the particle. The binding of the shell utilizes a guanidinium-phosphonate interaction analogous to the one exploited by the Wender molecular transporter system. Particle-shell binding was characterized by a 27% decrease in19F T1of the fluorous shell upon exposure to the paramagnetic gadolinium in the particle and a corresponding increase in hydrodynamic diameter from 3 nm to 4 nm. Interestingly, a much smaller modulation of19F T1is observed when the shell monomer is treated with a phosphonate-free particle. By contrast, the phosphonate-free particle is a much more relaxive1H T1agent for water. Together, these observations show that the fluoroalkylguanidinium shell binds selectively to the phosphonate-covered particle. The system's relaxivity and selectivity give it potential for use in19F based nanotheranostic agents.
authors.affiliation: Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, 837 Bloom Walk, Los Angeles, CA 90089-1661, USA.
authors.forename: Vincent
authors.initials: V
authors.lastname: Li
authors.forename: Andy Y
authors.initials: AY
authors.lastname: Chang
authors.forename: Travis J
authors.initials: TJ
authors.lastname: Williams
keywords: Fluorine; Gold nanoparticle; Relaxivity; Surfaces; Theranostic
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