title: Serous carcinoma of the ovary with squamous differentiation: a case report and a literature review.
abstract: Serous carcinoma of the ovary showing squamous differentiation is a rarely reported neoplasm. We present 1 case of such a tumor extensively involving the adnexa and the pelvis, which shows these 2 intimately entwined, yet with morphologically and immunohistochemically distinct patterns of differentiation. We also report immunohistochemical evidence of protein expression changes in areas of this carcinoma that provide evidence for differentiation from a serous to a squamous phenotype.
authors.affiliation: Department of Pathology, Stanford University, Stanford El Camino Hospital, Mountain View, CA, USA.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Roberts
authors.forename: Charles M
authors.initials: CM
authors.lastname: Lombard
mesh_terms: D000290:Adnexa Uteri / Q000378:metabolism / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008679:Metaplasia / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D010053:Ovary / Q000378:metabolism / Q000473:pathology; D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors / Q000378:metabolism; D010388:Pelvis / Q000473:pathology; D010641:Phenotype; D025721:WT1 Proteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D051761:Paired Box Transcription Factors; D025721:WT1 Proteins; C583751:WT1 protein, human