title: How to switch a master switch.
abstract: The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras.
authors.affiliation: is at the Institute of Biophysical Chemistry and the Buchmann Institute of Molecular Life Sciences , Goethe University , Frankfurt , Germany hein@bpc.uni-frankfurt.de.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hein
authors.forename: Alfred
authors.initials: A
authors.lastname: Wittinghofer
authors.forename: Volker
authors.initials: V
authors.lastname: Dötsch
mesh_terms: D004268:DNA-Binding Proteins / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006801:Humans
chemical_list: D004268:DNA-Binding Proteins; D020662:Guanine Nucleotide Exchange Factors
keywords: Human; cell signalling; diacylglycerol; nucleotide exchange factor
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