title: MRI features of inflammatory hepatocellular adenomas on hepatocyte phase imaging with liver-specific contrast agents.
abstract: OBJECTIVE
  To evaluate the presentation of inflammatory hepatocellular adenomas (HCAs) on hepatocyte phase MRI.
  
  
  METHODS
  We retrospectively reviewed the MRI features of histologically proven HCAs on hepatocyte phase imaging. Twenty-one lesions (17 with inflammatory subtype) were scanned with gadobenate dimeglumine. Signal intensities of the lesions were assessed in the hepatocyte phase and on the T1-weighted sequences before contrast.
  
  
  RESULTS
  After gadobenate dimeglumine injection, 71% (12/17) of the inflammatory HCAs showed areas of iso- or hyperintensity to the surrounding liver in the hepatocyte phase. In 82% (10/12) of the iso- or hyperintense lesions, this was found over more than 75% of the lesion surface. None of the noninflammatory HCAs showed areas of iso- or hyperintensity to the surrounding liver in the hepatocyte phase. From these 12, 7 were hyperintense on T1-weighting before contrast due to liver steatosis, 2 due to intrinsic hyperintensity (on the in-phase sequence), and 3 were isointense.
  
  
  CONCLUSIONS
  In contrast to noninflammatory HCAs, inflammatory HCAs can show areas of iso- to hyperintensity to the surrounding liver in the hepatocyte phase; therefore, other typical imaging features should also be used to distinguish between HCAs and FNHs.
authors.affiliation: Department of Radiology, Erasmus MC, CA Rotterdam, The Netherlands.
authors.forename: Maarten G
authors.initials: MG
authors.lastname: Thomeer
authors.forename: Francois E
authors.initials: FE
authors.lastname: Willemssen
authors.forename: Katharina K
authors.initials: KK
authors.lastname: Biermann
authors.forename: Haroun
authors.initials: H
authors.lastname: El Addouli
authors.forename: Rob A
authors.initials: RA
authors.lastname: de Man
authors.forename: Jan N
authors.initials: JN
authors.lastname: Ijzermans
authors.forename: Roy S
authors.initials: RS
authors.lastname: Dwarkasing
mesh_terms: D018248:Adenoma, Liver Cell / Q000473:pathology*; D000328:Adult; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000473:pathology*; D006505:Hepatitis / Q000150:complications / Q000473:pathology*; D022781:Hepatocytes / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008113:Liver Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D008875:Middle Aged; D009942:Organometallic Compounds; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine
keywords: MRI; gadobenate dimeglumine; gadoxetate disodium; hepatocellular adenoma