title: PEG-silica-modified gold nanorods that retain their optical properties in tumor tissues.
abstract: Gold nanorods modified with polyethylene glycol (PEG) chains via Au-S bonds form aggregates, and their absorption spectra broaden in tumor tissues. In contrast, the gold nanorods modified here via the crosslinking of PEG chains on the silica shell on gold nanorods showed enhanced permeability and retention effects and retained the optical properties of the original gold nanorods in tumor tissues.
authors.affiliation: a Department of Applied Chemistry , Faculty of Engineering Kyushu University , 744 Motooka, Nishi-ku, Fukuoka , 819-0395 , Japan .
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Akiyama
authors.forename: Yasuro
authors.initials: Y
authors.lastname: Niidome
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
authors.forename: Takuro
authors.initials: T
authors.lastname: Niidome
mesh_terms: D000042:Absorption; D000818:Animals; D001692:Biological Transport; D006046:Gold / Q000737:chemistry*; D008297:Male; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D055620:Optical Phenomena; D011092:Polyethylene Glycols / Q000737:chemistry*; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D011092:Polyethylene Glycols; D006046:Gold; D012822:Silicon Dioxide