title: Recent development of new substituted indole and azaindole derivatives as anti-HIV agents.
abstract: Human immunodeficiency virus-1 (HIV-1) infections cause global health problems. Indole derivatives have been considered as one of the promising HIV inhibitors. Recent inventions have focused on substituted indole and azaindole derivatives that possess unique antiviral activities against HIV-1. In this review, the evaluation of recent advances in substituted indole and azaindole derivatives for the treatment or prevention of HIV-1 and acquired immune deficiency syndrome (AIDS) has been focused. In this respect, compounds having drug and bio-active properties, including their synthesis and pharmacologic properties have been reported. In addition, anti-HIV properties of compounds, the structural features of inhibitors, the current progress in terms of therapeutic interventions and the leading groups in the field are discussed. Moreover, clinical and ADME (Absorption, Distribution, Metabolism, Elimination) properties of some clinically important compounds such as BMS-378806, L-737126 and IDX899 are reported.
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, 06100, Turkey. olgen@ankara.edu.tr.
authors.forename: Süreyya
authors.initials: S
authors.lastname: Ölgen
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000627:therapeutic use*; D001372:Aza Compounds / Q000737:chemistry; D015658:HIV Infections / Q000188:drug therapy*; D054303:HIV Reverse Transcriptase / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D010330:Patents as Topic; D011485:Protein Binding; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D001372:Aza Compounds; D007211:Indoles; D018894:Reverse Transcriptase Inhibitors; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase