title: Aspirin: a potential therapeutic approach in pancreatic cancer.
abstract: Inflammation has become a research hotspot in solid tumours and has been confirmed as a key factor in tumour development through the interactions of inflammatory mediators with gene expression, cell proliferation, and apoptosis. Pancreatic cancer (PC) is one of the most aggressive and deadliest forms of gastrointestinal cancer. A large case-control study found that aspirin, an anti-inflammatory drug, was associated with a decreased risk of PC. Moreover, aspirin has been shown to have inhibitory effects on PC in both in vitro and in vivo studies. However, the clinical data analysis has not been similarly promising. Results from genetic and pharmacological studies suggest that the anti-tumour effects of aspirin are mediated, at least in part, through the inhibition of COXs. Furtermore, other results suggest that the chemopreventive and therapeutic effects of aspirin are also mediated through COX-independent mechanisms. The COX-dependent and COX-independent mechanisms will be described in this review. In addition, we will discuss future research directions on the risks and benefits of the use of aspirin to treat PC and the potential cellular/molecular.
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, Shaanxi, China. qyma56@mail.xjtu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Shen
authors.forename: Liang
authors.initials: L
authors.lastname: Han
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Ma
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Wanxing
authors.initials: W
authors.lastname: Duan
authors.forename: Shuo
authors.initials: S
authors.lastname: Yu
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.forename: Lun
authors.initials: L
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Qinhong
authors.initials: Q
authors.lastname: Xu
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Ma
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D051545:Cyclooxygenase 1 / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D001241:Aspirin