title: Host restriction of lentiviruses and viral countermeasures: APOBEC3 and Vif.
abstract: It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif.
authors.affiliation: Institute for Experimental Pathology, University of Iceland, Keldur, 112 Reykjavik, Iceland. stefanjo@hi.is
authors.forename: Stefán R
authors.initials: SR
authors.lastname: Jónsson
authors.forename: Valgerdur
authors.initials: V
authors.lastname: Andrésdóttir
mesh_terms: D000818:Animals; D043525:Cytosine Deaminase / Q000276:immunology* / Q000378:metabolism*; D016346:Gene Products, vif / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000821:virology; D037521:Virulence Factors / Q000378:metabolism*; D014790:Visna-maedi virus / Q000276:immunology*
chemical_list: D016346:Gene Products, vif; D037521:Virulence Factors; D043525:Cytosine Deaminase
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