title: Controllable in situ synthesis of magnetite coated silica-core water-dispersible hybrid nanomaterials.
abstract: Magnetite nanoparticle coated silica (Fe3O4@SiO2) hybrid nanomaterials hold an important position in the fields of cell imaging and drug delivery. Here we report a large scale synthetic procedure that allows attachment of magnetite nanoparticles onto a silica surface in situ. Many different silica nanomaterials such as Stöber silica nanospheres, mesoporous silica nanoparticles, and hollow silica nanotubes have been coated with a high density layer of water-dispersible magnetite nanoparticles. The size and attachment efficiency of the magnetite nanoparticle can be well tuned by adjusting the precursor concentration and reflux time. The functionalization of Fe3O4@SiO2 nanoparticles with dye molecules and biocompatible polymers impart optical imaging modality and good colloidal stability in either buffer solution or serum. The functionalized materials also exhibited strong potential as negative contrast agents in T2 weighted magnetic resonance imaging.
authors.affiliation: Advanced Materials Research Institute, University of New Orleans, New Orleans 70148, USA. haiou.qu@fda.hhs.gov
authors.forename: Haiou
authors.initials: H
authors.lastname: Qu
authors.forename: Sheng
authors.initials: S
authors.lastname: Tong
authors.forename: Kejing
authors.initials: K
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
authors.forename: Gang
authors.initials: G
authors.lastname: Bao
authors.forename: Seth
authors.initials: S
authors.lastname: Pincus
authors.forename: Weilie
authors.initials: W
authors.lastname: Zhou
authors.forename: Charles
authors.initials: C
authors.lastname: O'Connor
mesh_terms: D052203:Ferrosoferric Oxide / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water; D012822:Silicon Dioxide; D052203:Ferrosoferric Oxide
references.citation: J Am Chem Soc. 2003 Jul 2;125(26):7860-5
references.pmid: 12823004
references.citation: ACS Nano. 2012 Apr 24;6(4):3327-38
references.pmid: 22435911
references.citation: Eur J Med Chem. 2007 Jul;42(7):1032-8
references.pmid: 17336426
references.citation: Nano Lett. 2006 Nov;6(11):2427-30
references.pmid: 17090068
references.citation: J Am Chem Soc. 2008 Jan 9;130(1):28-9
references.pmid: 18076180
references.citation: J Am Chem Soc. 2010 Jan 20;132(2):552-7
references.pmid: 20017538
references.citation: J Phys Chem B. 2008 Nov 20;112(46):14390-4
references.pmid: 18671367
references.citation: Langmuir. 2011 Jun 7;27(11):7185-91
references.pmid: 21553827
references.citation: ACS Nano. 2008 Mar;2(3):477-84
references.pmid: 19206573
references.citation: Angew Chem Int Ed Engl. 2004 Dec 17;44(1):123-6
references.pmid: 15599914
references.citation: Angew Chem Int Ed Engl. 2006 Dec 11;45(48):8160-2
references.pmid: 17103471
references.citation: ACS Nano. 2011 Feb 22;5(2):1122-40
references.pmid: 21218795
references.citation: ACS Appl Mater Interfaces. 2012 Feb;4(2):1003-9
references.pmid: 22235867
references.citation: ACS Nano. 2013 Jun 25;7(6):5142-50
references.pmid: 23659350
references.citation: Langmuir. 2013 Jan 29;29(4):1286-94
references.pmid: 23281806
references.citation: Langmuir. 2008 Mar 4;24(5):1714-20
references.pmid: 18225928
references.citation: J Am Chem Soc. 2005 Nov 9;127(44):15362-3
references.pmid: 16262387
references.citation: Angew Chem Int Ed Engl. 2006 Jul 17;45(29):4789-93
references.pmid: 16802396
references.citation: ACS Nano. 2013 Jan 22;7(1):330-8
references.pmid: 23199030
references.citation: Langmuir. 2011 Mar 15;27(6):2271-8
references.pmid: 21284390
references.citation: ACS Nano. 2008 Feb;2(2):197-202
references.pmid: 19206619
references.citation: ACS Appl Mater Interfaces. 2011 Jul;3(7):2479-86
references.pmid: 21604817