title: Phenolic glycosides and other constituents from the bark of Magnolia officinalis.
abstract: A new phenolic glycoside, syringic acid 4-O-β-D-glucopyranosyl-(1 → 5)-α-L-rhamnopyranoside (1), together with 12 known compounds consisting of eight phenolic glycosides (2-9), two phenolic acids (10 and 11), and two norsesquiterpenoids (12 and 13), was isolated from the methanol extract of the bark of Magnolia officinalis. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. Compounds 1-11 were evaluated for their inhibitory activities against fructose-1,6-bisphosphatase, aldose reductase, lipase, dipeptidyl peptidase-IV, α-glucosidase, and three cancer cell lines. However, all the compounds showed weak or no activities in these tests.
authors.affiliation: a Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700 , China.
authors.forename: Ren-Yi
authors.initials: RY
authors.lastname: Yan
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Liu
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
mesh_terms: D000449:Aldehyde Reductase / Q000187:drug effects; D018819:Dipeptidyl Peptidase 4 / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008049:Lipase / Q000187:drug effects; D031566:Magnolia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D000520:alpha-Glucosidases / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D010636:Phenols; C000588519:syringic acid 4-O-beta-D-glucopyranosyl-(1-5)-alpha-L-rhamnopyranoside; D000449:Aldehyde Reductase; D008049:Lipase; D000520:alpha-Glucosidases; D018819:Dipeptidyl Peptidase 4