title: [Promising directions of search for antihypoxants and targets of their action].
abstract: The modem notions about mechanisms of the organism adaptation to hypoxia are reviewed. Promising new directions in the search for effective medicinal agents with antihypoxant action are proposed. Probable targets for antihypoxant action, including mitochondrial ATP-dependent potassium channel (mito-KATP), mitochondrial megapore (mPTP), and hypoxia-inducible factor-1alfa (HIF-1alpha) are discussed.
authors.forename: V E
authors.initials: VE
authors.lastname: Novikov
authors.forename: O S
authors.initials: OS
authors.lastname: Levchenkova
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000627:therapeutic use*; D055808:Drug Discovery; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism
chemical_list: D000975:Antioxidants; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D024101:Mitochondrial Proteins; D017506:H(+)-K(+)-Exchanging ATPase