title: Weighted model-based optoacoustic reconstruction in acoustic scattering media.
abstract: Model-based optoacoustic inversion methods are capable of eliminating image artefacts associated with the widely adopted back-projection reconstruction algorithms. Yet, significant image artefacts might also occur due to reflections and scattering of optoacoustically-induced waves from strongly acoustically-mismatched areas in tissues. Herein, we modify the model-based reconstruction methodology to incorporate statistically-based weighting in order to minimize these artefacts. The method is compared with another weighting procedure termed half-image reconstruction, yielding generally better results. The statistically-based weighting is subsequently verified experimentally, attaining quality improvement of the optoacoustic image reconstructions in the presence of acoustic mismatches in tissue phantoms and small animals ex-vivo.
authors.affiliation: Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany.
authors.forename: X Luís
authors.initials: XL
authors.lastname: Deán-Ben
authors.forename: Rui
authors.initials: R
authors.lastname: Ma
authors.forename: Amir
authors.initials: A
authors.lastname: Rosenthal
authors.forename: Vasilis
authors.initials: V
authors.lastname: Ntziachristos
authors.forename: Daniel
authors.initials: D
authors.lastname: Razansky
mesh_terms: D000162:Acoustics; D000465:Algorithms; D000818:Animals; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D015027:Zebrafish