title: Accumulation and detoxification of metals and arsenic in tissues of cattle (Bos taurus), and the risks for human consumption.
abstract: The aim of this study was to investigate metal accumulation and detoxification processes in cattle from polluted and unpolluted areas. Therefore dairy cows from farms and free ranging Galloway cows from nature reserves were used as study animals. The concentrations of Ag, Cd, Pb, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn and As were determined in muscle, kidney, liver and lungs of cattle from polluted and reference areas in Belgium. In kidney and liver also the metallothionein concentrations were measured. For Ag, Mn, Co, Cu, Zn and As the concentrations in the different tissues were significantly higher in the sampled Galloways than in the sampled dairy cows. On the other hand Cd and Pb were significantly higher in tissues of both cattle breeds from polluted sites. Cadmium seemed to be the most important metal for metallothionein induction in kidneys whereas Zn seemed to be the most important metal for the induction of metallothionein in the liver. This study also suggested that only for Mn and Cd a significant part of the uptake occurs via the lungs. Although in muscle none of the Cd and Pb levels exceeded the European limits for human consumption, 40% of the livers and 85% of the kidneys of all examined cows were above the European limit for cadmium. Based on the existing minimum risk levels (MRLs) for chronic oral exposure, the present results suggested that a person of 70kg should not eat more than 150g cow meat per day because of the Cr levels in the muscles.
authors.affiliation: Laboratory for Systemic Physiological and Ecotoxicological Research (SPHERE), Department of Biology, University of Antwerp, Groenenborgerlaan 171/U7, 2020 Antwerp, Belgium. Electronic address: saskiaroggeman@gmail.com.
authors.forename: Saskia
authors.initials: S
authors.lastname: Roggeman
authors.forename: Gudrun
authors.initials: G
authors.lastname: de Boeck
authors.forename: Hilde
authors.initials: H
authors.lastname: De Cock
authors.forename: Ronny
authors.initials: R
authors.lastname: Blust
authors.forename: Lieven
authors.initials: L
authors.lastname: Bervoets
mesh_terms: D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D001151:Arsenic / Q000378:metabolism / Q000493:pharmacokinetics*; D001530:Belgium; D002417:Cattle / Q000235:genetics / Q000378:metabolism*; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D005506:Food Contamination; D006801:Humans; D008658:Inactivation, Metabolic; D013058:Mass Spectrometry; D008668:Metallothionein / Q000378:metabolism; D008670:Metals / Q000378:metabolism / Q000493:pharmacokinetics*; D018570:Risk Assessment; D014018:Tissue Distribution
chemical_list: D008670:Metals; D008668:Metallothionein; D001151:Arsenic
keywords: Accumulation; Cattle; Human consumption; Metallothionein; Metals