title: Preparation of metallic pivot-based imprinted monolith for polar template.
abstract: One of the main challenges in MIPs preparation is the proper MIP monolith design for water-soluble compounds due to the difficulty in satisfying the demands of both good column permeability and affinity to polar template. A new strategy of metallic pivot in a ternary porogenic system of dimethyl sulfoxide (DMSO)-dimethylformamide (DMF)-1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF4) was suggested to solve this problem. An imprinted monolithic column with high porosity and good permeability was synthesized using a mixture of methyl gallate (template), 4-vinylpyridine, ethylene glycol dimethacrylate, and cobalt acetate. Some polymerization factors, such as template-monomer molar ratio and the composition of the ionic liquid, on the imprinting effect of the resulting MIPs monoliths were systematically investigated. In a mobile phase of acetonitrile-buffer, the greatest imprinting factor of 10.9 was obtained on the MIPs monolith with the optimized polymerization parameters. Thermodynamic analysis for separation demonstrated that the separation between the template and its analogs on the ion-mediated MIPs monolith is an enthalpy-controlled process.
authors.affiliation: Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Road, Urumqi 830011, Xinjiang, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Zhong
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Huang
authors.forename: Xue-Lei
authors.initials: XL
authors.lastname: Xin
authors.forename: Zhao-Sheng
authors.initials: ZS
authors.lastname: Liu
authors.forename: Haji Akber
authors.initials: HA
authors.lastname: Aisa
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation; D054802:Molecular Imprinting; D010539:Permeability; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D016062:Porosity; D013816:Thermodynamics
chemical_list: D011108:Polymers
keywords: Ionic liquid; Metal ions; Methyl gallate; Molecular recognition; Molecularly imprinted polymer; Monolith