title: Antimutagenic and antioxidant activities of some bioflavours from wine.
abstract: Monoterpenes limonene and its metabolic derivatives, α-terpineol and 1,8-cineol, commonly found as aroma wine components, were studied for their antimutagenicity by the bacterial reverse mutation assay on different strains. Substances were also tested for their antioxidant activity, i.e. radical scavenger, chelation, reduction, and lipid peroxidation inhibition. Limonene and its metabolites, α-terpineol and 1,8-cineol, resulted able to inhibit the chemically-induced mutagenesis, although with a different specificity. The antimutagenicity of limonene has been generally retained by its metabolites and sometimes increased. In particular, α-terpineol exhibited the strongest inhibition, moreover it showed to be a remarkable ferrous ions chelating agent. Limonene and 1,8-cineol were devoid of antioxidant activity. Present results are a starting point in evaluating the potential of α-terpineol as a chemopreventive agent and suggest potential functional dietary benefits of wine.
authors.affiliation: Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy. Electronic address: antonella.disotto@uniroma1.it.
authors.forename: Di Sotto
authors.initials: DS
authors.lastname: Antonella
authors.forename: Durazzi
authors.initials: D
authors.lastname: Federico
authors.forename: Sarpietro Maria
authors.initials: SM
authors.lastname: Grazia
authors.forename: Mazzanti
authors.initials: M
authors.lastname: Gabriela
mesh_terms: D016587:Antimutagenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D000081005:Cyclohexane Monoterpenes; D003511:Cyclohexanols / Q000032:analysis / Q000494:pharmacology; D053138:Cyclohexenes / Q000032:analysis / Q000494:pharmacology; D000077591:Eucalyptol; D000077222:Limonene; D016014:Linear Models; D039821:Monoterpenes / Q000032:analysis / Q000494:pharmacology; D013649:Taste / Q000502:physiology; D013729:Terpenes / Q000032:analysis / Q000494:pharmacology; D014920:Wine / Q000032:analysis*
chemical_list: D016587:Antimutagenic Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D000081005:Cyclohexane Monoterpenes; D003511:Cyclohexanols; D053138:Cyclohexenes; D039821:Monoterpenes; D013729:Terpenes; C016775:alpha-terpineol; D000077222:Limonene; D000077591:Eucalyptol
keywords: 1,8-Cineol; Bioflavor; Chemoprevention; Limonene metabolites; Wine; α-Terpineol