title: Bud building by septin patch hole punching.
abstract: Small GTPase Cdc42 triggers polarity establishment in budding yeast. In this issue of Developmental Cell, Okada et al. (2013) combine in silico modeling and cell biology to show that Cdc42, septins, and the exocytosis pathway are integrated in a feedback system to define and insulate the site of polarity in the membrane.
authors.affiliation: Department of Biology, Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Caudron
authors.forename: Yves
authors.initials: Y
authors.lastname: Barral
mesh_terms: D005089:Exocytosis / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D058112:Septins / Q000378:metabolism*; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / Q000378:metabolism*
chemical_list: D058112:Septins; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae