title: Zonisamide in the treatment of bulimia nervosa: an open-label, pilot, prospective study.
abstract: OBJECTIVE
  To assess preliminarily the effectiveness of zonisamide in bulimia nervosa.
  
  
  METHODS
  This was an open-label, prospective, 12-week, flexible dose study of zonisamide in bulimia nervosa. The primary outcome was binge-purge episode frequency.
  
  
  RESULTS
  Twelve individuals received zonisamide, 10 completed at least one post-baseline evaluation, and six completed the study. Mean dose at endpoint was 420 (SD = 215) mg/day. Zonisamide was associated with significant reductions in frequency of binge-purge episodes and binge-purge days as well as measures of binge eating behavior, purging behavior, clinical severity, obsessive-compulsive features, and depressive symptoms. Weight was unchanged.
  
  
  CONCLUSIONS
  In this open-label trial, zonisamide was effective in bulimia nervosa, but associated with a high discontinuation rate.
authors.affiliation: Lindner Center of HOPE, Mason, Ohio; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio.
authors.forename: Anna I
authors.initials: AI
authors.lastname: Guerdjikova
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Blom
authors.forename: Brian E
authors.initials: BE
authors.lastname: Martens
authors.forename: Paul E
authors.initials: PE
authors.lastname: Keck
authors.forename: Susan L
authors.initials: SL
authors.lastname: McElroy
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D015992:Body Mass Index; D052018:Bulimia Nervosa / Q000188:drug therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D055118:Medication Adherence; D011446:Prospective Studies; D000078305:Zonisamide
chemical_list: D000927:Anticonvulsants; D007555:Isoxazoles; D000078305:Zonisamide
keywords: antiepileptic; bulimia nervosa; eating disorder; zonisamide