title: Determinants of suicidal ideation in patients with breast cancer.
abstract: BACKGROUND
  Breast cancer survivors are at higher risk of psychological problems including suicidal ideation. However, studies on suicidal ideation in breast cancer survivors have been rare and have not been investigated prospectively. This study aimed to investigate the prevalence and independent risk factors for suicidal ideation within 1 week and at 1 year after breast surgery for breast cancer.
  
  
  METHODS
  A total of 284 patients with breast cancer were evaluated within 1 week after breast surgery, and 244 (84%) were followed up 1 year later. Suicidal ideation was ascertained using the item 'suicidal thoughts' from the Beck Depression Inventory. Various factors potentially related to suicidal ideation were evaluated including sociodemographic and clinical characteristics, and genetic polymorphisms on serotonin and brain-derived neurotrophic factor (BDNF) systems.
  
  
  RESULTS
  Suicidal ideation was present in 10.9% of participants at 1 week and 11.4% at 1 year after breast surgery. Suicidal ideation was independently associated with depression and physical disability at 1 week and with living alone, anxiety, advanced cancer stage, and the BDNF met allele (but not with genetic polymorphisms on serotonergic system) at 1 year after breast surgery.
  
  
  CONCLUSIONS
  Suicidal ideation was common and had similar prevalences in both short-term and longer-term follow-ups after breast cancer. However, associated factors were substantially different between the two evaluation points, which suggest that time-specific programs may be needed for identifying and managing suicidal risk in patients with breast cancer.
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Jang
authors.forename: Robert
authors.initials: R
authors.lastname: Stewart
authors.forename: Seon-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Sung-Wan
authors.initials: SW
authors.lastname: Kim
authors.forename: Hee-Ju
authors.initials: HJ
authors.lastname: Kang
authors.forename: Il-Seon
authors.initials: IS
authors.lastname: Shin
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Park
authors.forename: Jung-Han
authors.initials: JH
authors.lastname: Yoon
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
mesh_terms: D000328:Adult; D001007:Anxiety / Q000523:psychology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D001943:Breast Neoplasms / Q000473:pathology / Q000523:psychology* / Q000601:surgery; D003866:Depressive Disorder / Q000523:psychology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D012111:Residence Characteristics; D012307:Risk Factors; D016728:Self-Injurious Behavior / Q000235:genetics / Q000523:psychology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D059020:Suicidal Ideation; D017741:Survivors / Q000523:psychology*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C579455:BDNF protein, human
keywords: BDNF; cancer; depression; oncology; suicidal ideation