title: N-substituted 1,2-dihydroquinolines as anticancer agents: electronic control of redox stability, assessment of antiproliferative effects, and mechanistic insights.
abstract: Redox chemotherapy: Antiproliferative activities of a series of N-substituted 1,2-dihydroquinolines capable of causing redox imbalance in cancer cells are presented. Detailed studies showed that these derivatives arrest the cell cycle in the G2/M phase and induce apoptosis through an intrinsic pathway characterized by loss of mitochondrial membrane potential, DNA fragmentation, cytochrome c release, and activation of caspases 9 and 3.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600 036 (India).
authors.forename: Napoleon
authors.initials: N
authors.lastname: John Victor
authors.forename: Ramasamy
authors.initials: R
authors.lastname: Sakthivel
authors.forename: Kannoth Manheri
authors.initials: KM
authors.lastname: Muraleedharan
authors.forename: Devarajan
authors.initials: D
authors.lastname: Karunagaran
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D059565:G2 Phase Cell Cycle Checkpoints / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints / Q000187:drug effects; D010084:Oxidation-Reduction; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D011804:Quinolines; D017382:Reactive Oxygen Species
keywords: G2/M cell‐cycle arrest; apoptosis; cytotoxic agents; dihydroquinolines; reactive oxygen species