title: Incidence of Cholangiocarcinoma with or without Previous Resection of Liver for Hepatolithiasis.
abstract: OBJECTIVE
  To investigate the incidence of cholangiocarcinoma in patients with hepatolithiasis with or without previous resection of liver.
  
  
  METHODS
  From 2002 to 2009, we retrospectively reviewed 117 patients who were diagnosed and treated for hepatolithiasis in Korea University Guro Hospital. Among the 117 patients, 55 patients who were lost during follow-up were excluded, and 62 patients were eligible for analysis. The hepatic resection group (n=25) included patients who underwent left hemihepatectomy (n=2); left lateral segmentectomy (n=10); left lobectomy (n=9); right lobectomy (n=3); or wedge resection (n=1). The nonhepatic resection group (n=37) included transhepatic cholangiographic lithotomy and endoscopic retrograde cholangiopancreatography-treated patients. The mean follow-up period was 47 months.
  
  
  RESULTS
  The incidence of cholangiocarcinoma while patients were followed for hepatolithiasis was 12.9% (8/62) (hepatic resection group, three cases [12%] vs nonhepatic resection group, five cases [13.5%]; p=1.000). The mean follow-up period was 53 months (47±11 months) until the diagnosis of cholangiocarcinoma.
  
  
  CONCLUSIONS
  There was no difference in the incidence of cholangiocarcinoma according to previous liver resections. Patients with hepatolithiasis should be carefully followed up for detection of cholangiocarcinoma even after a previous liver resection.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Jae Seon
authors.initials: JS
authors.lastname: Kim
authors.forename: Ji Mi
authors.initials: JM
authors.lastname: Moon
authors.forename: Sang-Ah
authors.initials: SA
authors.lastname: Lim
authors.forename: Wonho
authors.initials: W
authors.lastname: Chung
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Lim
authors.forename: Beom Jae
authors.initials: BJ
authors.lastname: Lee
authors.forename: Jong-Jae
authors.initials: JJ
authors.lastname: Park
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Bak
keywords: Cholangiocarcinoma; Hepatolithiasis; Liver resection
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