title: Role of adipocytokines and its correlation with endocrine pancreatic function in patients with pancreatic cancer.
abstract: BACKGROUND
  Some authors suggest that adipocytokines contribute to the induction of pancreatic carcinogenesis as well as the development of endocrine insufficiency.
  
  
  OBJECTIVE
  We evaluate the circulating concentrations of leptin, resistin and visfatin in patients with newly diagnosed pancreatic cancer (PC) and relationship between serum adipocytokines level and clinicopathological features of PC. Moreover the usefulness of those adipocytokines as possible biomarkers of endocrine pancreatic function in PC has been assessed.
  
  
  METHODS
  The pilot study group consisted of 45 individuals (mean age 65.6 ± 11.5 years, BMI 21.8 ± 3.4 kg/m(2)) with newly diagnosed PC (within last 1-3 months) and 13 healthy individuals with age, gender and BMI matched to the study group. Among PC patients 18 (40%) had recently diagnosed diabetes. Fasting plasma leptin, resistin, visfatin concentrations were determined with ELISA (R&D Systems, Phoenix Pharmaceuticals) and insulin by RIA (DakoCytomation).
  
  
  RESULTS
  Patients with PC as compared to controls had significantly lower plasma leptin (40.6 ± 21.3 vs 63.2 ± 16.3 pg/mL; p < 0,0008). In contrast PC patients showed more than six fold higher level of resistin (126.2 ± 143.2 vs 18.9 ± 7.2 ng/mL; p < 0.009) than controls. The median plasma visfatin was 2.8 ± 1.8 ng/mL, which was not significantly different from the controls (3.8 ± 1.1 ng/mL). When PC patients with and without diabetes were considered separately, plasma leptin concentrations among nondiabetic patients were slightly, but not significantly higher (44.6 ± 21.0) as compared to diabetics (34.5 ± 20.7). Moreover there was no difference between visfatin and resistin level in PC, among patients with and without diabetes. No significant differences between serum level of leptin, visfatin and resistin and age, gender, BMI, smoking status, tumor localization, distant metastases and pain has been found.
  
  
  CONCLUSIONS
  The results of this study confirm previous findings that patients with newly diagnosed pancreatic cancer are characterized with lower level of leptin. This pilot study showed significantly higher resistin concentrations in patients with PC in comparison to healthy controls, which may be helpful in PC early diagnosis. Changes in leptin and resistin level in PC are not likely related to endocrine disorders.
authors.affiliation: Department of Digestive Tract Diseases, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, Poland. anita@sofcom.pl
authors.forename: Anita
authors.initials: A
authors.lastname: Gąsiorowska
authors.forename: Renata
authors.initials: R
authors.lastname: Talar-Wojnarowska
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kaczka
authors.forename: Anna
authors.initials: A
authors.lastname: Borkowska
authors.forename: Leszek
authors.initials: L
authors.lastname: Czupryniak
authors.forename: Ewa
authors.initials: E
authors.lastname: Małecka-Panas
mesh_terms: D054392:Adipokines / Q000097:blood*; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D007515:Islets of Langerhans / Q000502:physiology*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D010190:Pancreatic Neoplasms / Q000503:physiopathology*; D052243:Resistin / Q000097:blood
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D020738:Leptin; D052243:Resistin; D054409:Nicotinamide Phosphoribosyltransferase
keywords: Diabetes; Leptin; Pancreatic cancer; Resistin; Visfatin