title: The effect of L-carnosine on erythrocyte deformability and aggregation according to the cell age in young and aged rats.
abstract: This study aimed to investigate alterations in hemorheology induced by L-carnosine, an anti- oxidant dipeptide, and to determine their relationship to oxidative stress in density-separated erythrocytes of aged and young rats. 28 male Sprague Dawley rats were divided into 4 groups as aged (Aca), young (Yca) L-carnosine groups (250 mg/kg L-carnosine, i.p.) and aged (As), young (Ys) control groups (saline, i.p.). Density separation was further performed to these groups in order to separate erythrocytes according to their age. Blood samples were used for the determination of erythrocyte deformability, aggregation; and oxidative stress parameters. Erythrocyte deformability of Yca group measured at 0.53 Pa was lower than Aca group. Similarly, deformability of least-dense (young) erythrocytes of Yca group was decreased compared to least-dense erythrocytes of Aca groups. Total antioxidant capacity (TAC) of Aca group was higher and oxidative stress index (OSI) lower than As group. Although L-carnosine resulted in an enhancement in TAC of aged rats, this favorable effect was not observed in erythrocyte deformability and aggregation in the dose applied in this study.
authors.affiliation: Balikesir University, Faculty of Medicine, Department of Physiology, Balikesir, Turkey. gulemmun@gmail.com
authors.forename: Gülten
authors.initials: G
authors.lastname: Erken
authors.forename: Melek
authors.initials: M
authors.lastname: Bor-Kucukatay
authors.forename: Emine
authors.initials: E
authors.lastname: KilicToprak
authors.forename: Beyza
authors.initials: B
authors.lastname: Akdag
authors.forename: Vural
authors.initials: V
authors.lastname: Kucukatay
mesh_terms: D000367:Age Factors; D000818:Animals; D002336:Carnosine / Q000494:pharmacology*; D016922:Cellular Senescence / Q000502:physiology*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002336:Carnosine