title: Insulin resistance possible risk factor for cognitive impairment in fibromialgic patients.
abstract: To evaluate glucose metabolism and/or insulin resistance (IR) in 96 patients with Fibromyalgia (FM), associated or not to cognitive impairment. We investigated glucose metabolism in 96 FM patients. Enrolled patients were divided into two groups: 48 patients with memory deficit (group A) and 48 without memory deficit (control group). We evaluated glucose and insulin levels after a 2 h-Oral-Glucose-Tolerance-Test (2 h-OGTT) and insulin resistance (IR) by the homeostasis model assessment formula (HOMA). Body Mass Index (BMI), waist-to-hip-ratio (WHR), anxiety level, fasting plasma insulin and Non-Steroidal Anti-Inflammatory agents use were higher in patients with FM with memory impairment; while age, sex, waist circumference, education level, fasting plasma glucose, glycate hemoglobin, triglycerides, blood lipid profile, C- Reactivity-Protein (CRP), blood pressure and smoking habits were similar in both groups. Following OGTT the prevalence of glucose metabolism abnormalities was significantly higher in group A. IR was present in 79% patients, of whom 23% had also impaired glucose tolerance, 4% newly diagnosed diabetes mellitus and 52% IR only. Obesity and overweight prevailed in group A. IR, but not BMI or WHR was associated to an increased risk of memory impairment (OR = 2,6; 95% CI: 1,22-3,7). The results of this study suggest that IR may represent a risk factor for memory impairment in fibromialgic patients.
authors.affiliation: Endocrinology, Fondazione UALSI, Catanzaro, 88100, Italy.
authors.forename: Antonietta
authors.initials: A
authors.lastname: Fava
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Plastino
authors.forename: Dario
authors.initials: D
authors.lastname: Cristiano
authors.forename: Antonio
authors.initials: A
authors.lastname: Spanò
authors.forename: Stefano
authors.initials: S
authors.lastname: Cristofaro
authors.forename: Carlo
authors.initials: C
authors.lastname: Opipari
authors.forename: Antonio
authors.initials: A
authors.lastname: Chillà
authors.forename: Fatima
authors.initials: F
authors.lastname: Casalinuovo
authors.forename: Carmen
authors.initials: C
authors.lastname: Colica
authors.forename: Matteo
authors.initials: M
authors.lastname: De Bartolo
authors.forename: Domenico
authors.initials: D
authors.lastname: Pirritano
authors.forename: Domenico
authors.initials: D
authors.lastname: Bosco
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism / Q000523:psychology; D005260:Female; D005356:Fibromyalgia / Q000150:complications* / Q000378:metabolism / Q000523:psychology; D018149:Glucose Intolerance / Q000150:complications* / Q000378:metabolism / Q000523:psychology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin
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