title: Oral premalignancy: the roles of early detection and chemoprevention.
abstract: Premalignancy and chemoprevention studies in head and neck cancer typically focus on the oral cavity. Avoiding or cessation of alcohol and smoking, early detection of potentially malignant disorders or cancer, and early detection of recurrent and/or second primary tumor form the basis of prevention of oral cancer. Analysis of tissue prospectively collected in evaluation of retinoids for chemoprevention trials allowed identification of molecular biomarkers of risk to develop oral cancer, loss of heterozygosity being the most validated one. Improving risk assessment and identification of new targets for chemoprevention represent the main challenges in this field.
authors.affiliation: Department of Maxillofacial Surgery, Pitié-Salpêtrière Hospital, 47-83 boulevard de l' Hôpital, Paris 75013, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Foy
authors.forename: Chloé
authors.initials: C
authors.lastname: Bertolus
authors.forename: William N
authors.initials: WN
authors.lastname: William
authors.forename: Pierre
authors.initials: P
authors.lastname: Saintigny
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D018890:Chemoprevention; D042241:Early Diagnosis; D006801:Humans; D007972:Leukoplakia, Oral / Q000473:pathology* / Q000628:therapy*; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D012176:Retinoids / Q000627:therapeutic use
chemical_list: D012176:Retinoids
keywords: Biomarkers of risk; Chemoprevention; Head and neck cancer; Head and neck squamous cell carcinoma; Loss of heterozygocity; Oral squamous cell carcinoma; Potentially malignant disorder
references.citation: Cancer Sci. 2003 Apr;94(4):365-71
references.pmid: 12824906
references.citation: N Engl J Med. 1993 Jan 7;328(1):15-20
references.pmid: 8416267
references.citation: Clin Cancer Res. 2000 Feb;6(2):357-62
references.pmid: 10690511
references.citation: Nat Med. 1996 Jun;2(6):682-5
references.pmid: 8640560
references.citation: J Oral Pathol Med. 2008 Mar;37(3):127-33
references.pmid: 18251935
references.citation: Cancer Res. 1994 Jul 1;54(13):3580-7
references.pmid: 8012985
references.citation: N Engl J Med. 2011 Aug 4;365(5):395-409
references.pmid: 21714641
references.citation: Head Neck. 2008 Jan;30(1):75-84
references.pmid: 17694557
references.citation: Anticancer Res. 1998 Nov-Dec;18(6B):4779-86
references.pmid: 9891557
references.citation: Cancer. 2001 Oct 1;92(7):1888-95
references.pmid: 11745262
references.citation: Cancer Res. 2000 Jul 15;60(14):3893-8
references.pmid: 10919665
references.citation: Lancet Oncol. 2007 May;8(5):439-43
references.pmid: 17466901
references.citation: J Otolaryngol. 1984 Feb;13(1):1-6
references.pmid: 6716542
references.citation: Cancer Prev Res (Phila). 2010 Aug;3(8):900-9
references.pmid: 20663981
references.citation: Cancer Prev Res (Phila). 2010 Apr;3(4):393
references.pmid: 20354167
references.citation: Cancer Res. 1993 Aug 1;53(15):3579-84
references.pmid: 8339264
references.citation: Cochrane Database Syst Rev. 2010 Nov 10;(11):CD004150
references.pmid: 21069680
references.citation: Nature. 2008 Apr 3;452(7187):633-7
references.pmid: 18385738
references.citation: Carcinogenesis. 2006 Mar;27(3):619-30
references.pmid: 16219633
references.citation: Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):595-601
references.pmid: 11401908
references.citation: J Clin Oncol. 2007 Jun 1;25(16):2164-70
references.pmid: 17538160
references.citation: Science. 2011 Aug 26;333(6046):1157-60
references.pmid: 21798893
references.citation: Lancet. 2005 Jun 4-10;365(9475):1927-33
references.pmid: 15936419
references.citation: Lasers Surg Med. 2011 Mar;43(3):192-9
references.pmid: 21412802
references.citation: Acta Otorhinolaryngol Ital. 2012 Feb;32(1):1-11
references.pmid: 22500060
references.citation: J Oral Pathol Med. 2007 Nov;36(10):575-80
references.pmid: 17944749
references.citation: Cancer Prev Res (Phila). 2011 Jul;4(7):962-72
references.pmid: 21733820
references.citation: J Natl Cancer Inst. 1994 Jan 19;86(2):140-1
references.pmid: 8271298
references.citation: Cancer Prev Res (Phila). 2011 Feb;4(2):185-93
references.pmid: 21292633
references.citation: Cancer Res. 2002 Nov 15;62(22):6447-50
references.pmid: 12438233
references.citation: Infect Agent Cancer. 2012 May 30;7(1):13
references.pmid: 22647139
references.citation: J Clin Oncol. 2003 Dec 15;21(24):4546-52
references.pmid: 14597742
references.citation: Head Neck. 2006 Oct;28(10):945-54
references.pmid: 16721744
references.citation: Acta Derm Venereol. 1982;62(2):164-7
references.pmid: 6179345
references.citation: Cancer. 2006 Aug 1;107(3):563-9
references.pmid: 16804930
references.citation: Otolaryngol Head Neck Surg. 2004 Dec;131(6):986-93
references.pmid: 15577802
references.citation: Cancer Res. 1999 Jan 1;59(1):14-8
references.pmid: 9892176
references.citation: Int J Cancer. 2005 Jul 1;115(4):625-9
references.pmid: 15700313
references.citation: Oral Oncol. 2006 Nov;42(10):987-93
references.pmid: 16731030
references.citation: CA Cancer J Clin. 2012 Mar-Apr;62(2):129-42
references.pmid: 22261986
references.citation: Cancer Prev Res (Phila). 2008 Jun;1(1):39-44
references.pmid: 19138934
references.citation: Head Neck. 1996 Sep-Oct;18(5):433-40
references.pmid: 8864734
references.citation: J Am Dent Assoc. 2008 Oct;139(10):1346-52
references.pmid: 18832270
references.citation: Clin Cancer Res. 2000 May;6(5):1702-10
references.pmid: 10815888
references.citation: Eur J Cancer B Oral Oncol. 1993 Jan;29B(1):23-8
references.pmid: 8180572
references.citation: Curr Opin Oncol. 2012 May;24(3):205-10
references.pmid: 22273549
references.citation: Oral Oncol. 1998 Mar;34(2):77-83
references.pmid: 9682768
references.citation: Oral Oncol. 1997 Sep;33(5):332-7
references.pmid: 9415332
references.citation: Science. 2011 Aug 26;333(6046):1154-7
references.pmid: 21798897
references.citation: CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29
references.pmid: 22237781
references.citation: J Oral Pathol Med. 2008 Feb;37(2):63-9
references.pmid: 18197849
references.citation: Cancer Prev Res (Phila). 2009 Jul;2(7):617-24
references.pmid: 19584075
references.citation: Cancer Prev Res (Phila). 2012 Sep;5(9):1081-9
references.pmid: 22911111
references.citation: Cancer Res. 2008 Jun 15;68(12):4525-30
references.pmid: 18559496
references.citation: J Natl Cancer Inst. 1997 Feb 5;89(3):257-8
references.pmid: 9017007
references.citation: Cancer Prev Res (Phila). 2009 Nov;2(11):931-41
references.pmid: 19892663
references.citation: Cancer Lett. 1989 Dec;48(3):177-82
references.pmid: 2514039
references.citation: N Engl J Med. 1986 Dec 11;315(24):1501-5
references.pmid: 3537787
references.citation: Cancer Prev Res (Phila). 2009 Sep;2(9):823-9
references.pmid: 19737986
references.citation: Cancer Prev Res (Phila). 2010 Jul;3(7):800-9
references.pmid: 20570883
references.citation: J Pathol. 2008 Jul;215(3):347-8
references.pmid: 18421698
references.citation: Nat Genet. 2008 May;40(5):616-22
references.pmid: 18385676
references.citation: Clin Cancer Res. 2009 Oct 1;15(19):6284-91
references.pmid: 19773378
references.citation: Int J Epidemiol. 2010 Feb;39(1):182-96
references.pmid: 19805488
references.citation: Histopathology. 1999 Mar;34(3):226-33
references.pmid: 10217563
references.citation: J Oral Pathol Med. 1998 Nov;27(10):489-95
references.pmid: 9831962
references.citation: J Natl Cancer Inst. 2005 Apr 6;97(7):481-8
references.pmid: 15812073
references.citation: Clin Cancer Res. 2001 Jul;7(7):1860-6
references.pmid: 11448897
references.citation: Cancer Res. 1996 Jun 1;56(11):2488-92
references.pmid: 8653682
references.citation: Proc Am Thorac Soc. 2011 May;8(2):173-9
references.pmid: 21543797
references.citation: J Clin Oncol. 2008 Jan 20;26(3):354-60
references.pmid: 18202409
references.citation: Eur J Oral Sci. 2009 Oct;117(5):541-6
references.pmid: 19758250
references.citation: J Oral Pathol Med. 2012 Oct;41(9):682-8
references.pmid: 22697318
references.citation: Clin Cancer Res. 2004 Mar 1;10(5):1565-73
references.pmid: 15014005
references.citation: Cancer. 1984 Feb 1;53(3):563-8
references.pmid: 6537892
references.citation: Int J Cancer. 2007 Mar 15;120(6):1318-23
references.pmid: 17163423
references.citation: Lancet Oncol. 2010 Aug;11(8):781-9
references.pmid: 20451455
references.citation: Cancer Prev Res (Phila). 2011 Feb;4(2):218-29
references.pmid: 21292635
references.citation: N Engl J Med. 1996 May 2;334(18):1150-5
references.pmid: 8602180
references.citation: Clin Cancer Res. 2009 Nov 1;15(21):6724-31
references.pmid: 19861457
references.citation: Clin Cancer Res. 2008 Apr 1;14(7):2095-101
references.pmid: 18381950
references.citation: BMC Cancer. 2010 Dec 16;10:685
references.pmid: 21159209
references.citation: Blood. 2003 Feb 15;101(4):1249-56
references.pmid: 12393516
references.citation: Curr Oncol Rep. 2011 Apr;13(2):145-52
references.pmid: 21249481
references.citation: Cancer Res. 1995 Feb 15;55(4):853-61
references.pmid: 7850799
references.citation: Int J Cancer. 2005 Dec 10;117(5):831-6
references.pmid: 15957167
references.citation: Nat Clin Pract Oncol. 2009 Mar;6(3):132-3
references.pmid: 19190590
references.citation: Cancer. 1953 Sep;6(5):963-8
references.pmid: 13094644
references.citation: Cancer Res. 2009 Mar 1;69(5):1712-6
references.pmid: 19223530
references.citation: CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
references.pmid: 15761078
references.citation: J Maxillofac Surg. 1975 Mar;3(1):41-9
references.pmid: 47884
references.citation: Genes Chromosomes Cancer. 2000 Nov;29(3):201-6
references.pmid: 10992294
references.citation: N Engl J Med. 1994 Apr 14;330(15):1029-35
references.pmid: 8127329
references.citation: J Natl Cancer Inst. 2000 Jun 21;92(12):977-86
references.pmid: 10861309
references.citation: Nat Rev Drug Discov. 2009 Mar;8(3):213-25
references.pmid: 19247304
references.citation: Proc Soc Exp Biol Med. 1999 Apr;220(4):218-24
references.pmid: 10202392
references.citation: Head Neck. 2009 Dec;31(12):1600-9
references.pmid: 19455705
references.citation: J Clin Oncol. 2007 Apr 20;25(12):1476-81
references.pmid: 17442990
references.citation: J Laryngol Otol. 1993 Dec;107(12):1140-5
references.pmid: 8289004
references.citation: J Surg Oncol. 1988 Apr;37(4):232-4
references.pmid: 3361914
references.citation: J Am Dent Assoc. 2010 May;141(5):509-20
references.pmid: 20436098
references.citation: Oral Oncol. 2002 Feb;38(2):125-30
references.pmid: 11854058
references.citation: Cancer Prev Res (Phila). 2011 Feb;4(2):230-7
references.pmid: 21163936
references.citation: Oral Oncol. 2001 Sep;37(6):477-92
references.pmid: 11435174
references.citation: Oral Oncol. 2001 Sep;37(6):505-12
references.pmid: 11435177
references.citation: Nature. 2008 Apr 3;452(7187):638-642
references.pmid: 18385739
references.citation: Int J Epidemiol. 2010 Apr;39(2):563-77
references.pmid: 19776245
references.citation: J Oral Pathol Med. 2008 Jan;37(1):1-10
references.pmid: 18154571
references.citation: J Cell Biochem Suppl. 1995;22:11-7
references.pmid: 8538187
references.citation: Oral Dis. 1995 Mar;1(1):54-8
references.pmid: 7553382
references.citation: Oral Dis. 2010 May;16(4):333-42
references.pmid: 20233328
references.citation: J Natl Cancer Inst. 2006 Apr 5;98(7):441-50
references.pmid: 16595780
references.citation: Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):658-64
references.pmid: 21335511
references.citation: N Engl J Med. 1990 Sep 20;323(12):795-801
references.pmid: 2202902
references.citation: Int J Cancer. 2008 Sep 1;123(5):1005-14
references.pmid: 18546267
references.citation: J Clin Oncol. 2009 Feb 1;27(4):599-604
references.pmid: 19075276
references.citation: J Natl Cancer Inst. 1998 Oct 21;90(20):1545-51
references.pmid: 9790547
references.citation: J Am Dent Assoc. 1999 Jul;130(7):945-54
references.pmid: 10422398
references.citation: Clin Cancer Res. 2005 Sep 15;11(18):6505-11
references.pmid: 16166426
references.citation: Cancer Epidemiol Biomarkers Prev. 2001 Apr;10(4):391-5
references.pmid: 11319181
references.citation: Oral Oncol. 2003 Dec;39(8):759-69
references.pmid: 13679199