title: Use of local mitomycin C in enhancing laryngeal healing after laser cordotomy: a prospective controlled study.
abstract: BACKGROUND
  The purpose of this study was to investigate the role of intraoperative application of mitomycin C in prevention of glottic restenosis after posterior transverse CO2 laser cordotomy (PTLC) for patients with post-thyroidectomy bilateral vocal fold paralysis.
  
  
  METHODS
  Twenty-five patients with an impaired airway because of bilateral vocal fold paralysis were treated with PTLC. Patients were divided into groups: the mitomycin C group (13 patients) had PTLC and topical mitomycin C; and the control group (12 patients) had PTLC only.
  
  
  RESULTS
  No patients in the mitomycin C group developed glottic granulation or laryngeal scarring, whereas 5 of 12 patients in the control group developed granulation (p = .014) and 2 of 12 patients had laryngeal scarring (p = .28). Ten of 13 patients in the mitomycin C group ended up with mild dyspnea with no limitation to normal everyday activities whereas only a third of the control group achieved this outcome (p = .05).
  
  
  CONCLUSIONS
  The use of topical mitomycin C has been shown to decrease postoperative laryngeal granulation, scarring, restenosis, and the need for revision surgery.
authors.affiliation: Department of Otorhinolaryngology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Samya A
authors.initials: SA
authors.lastname: Fawaz
authors.forename: Sabri M
authors.initials: SM
authors.lastname: Sabri
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Sweed
authors.forename: Mona A
authors.initials: MA
authors.lastname: Hegazi
authors.forename: Magdi A
authors.initials: MA
authors.lastname: Riad
mesh_terms: D000328:Adult; D000477:Alkylating Agents / Q000008:administration & dosage*; D002921:Cicatrix / Q000517:prevention & control; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D007829:Laryngostenosis / Q000517:prevention & control*; D053685:Laser Therapy; D054020:Lasers, Gas / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D011446:Prospective Studies; D012008:Recurrence; D014826:Vocal Cord Paralysis / Q000601:surgery*; D014945:Wound Healing
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin
keywords: bilateral vocal fold paralysis; dyspnea grade; posterior cordotomy; topical mitomycin C; transverse laser cordotomy