title: Triple dissociation of attention networks in stroke according to lesion location.
abstract: OBJECTIVE
  To determine whether behavioral dissociations and interactions occur between the attentional functions-alerting, orienting, and conflict resolution-depending upon stroke location and to determine the approximate proportion of patients who can be classified into 1 of these 3 anatomical networks.
  
  
  METHODS
  We recruited 110 anatomically unselected acute stroke patients and 62 age-matched controls. Subjects underwent the attention network test (ANT), which provides a measure of each attention type. Their performance was related to lesion anatomy on MRI using a voxel-lesion mapping approach.
  
  
  RESULTS
  Patients as a whole performed poorer than controls, but there were no group differences in the size of attentional effects. Specific deficits in 1 of the 3 ANT-tested functions were found in the following lesion locations: alerting deficiency with bilateral anteromedial thalamus and upper brainstem (17% of patients); orienting impairment with right pulvinar and right temporoparietal cortex (15%); conflict resolution with bilateral prefrontal and premotor areas (23%). Lesions to right frontoparietal regions also modified interactions among the 3 types of attention.
  
  
  CONCLUSIONS
  More than half of all stroke patients can be expected to have a lesion location classifiable into 1 of the 3 principal attention networks. Our results have potential implications for therapy personalization in focal brain diseases including stroke.
authors.affiliation: Division of Brain Sciences, Imperial College London, Charing Cross Hospital Campus, London, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Rinne
authors.forename: Mursyida
authors.initials: M
authors.lastname: Hassan
authors.forename: Despina
authors.initials: D
authors.lastname: Goniotakis
authors.forename: Kiran
authors.initials: K
authors.lastname: Chohan
authors.forename: Pankaj
authors.initials: P
authors.lastname: Sharma
authors.forename: Dawn
authors.initials: D
authors.lastname: Langdon
authors.forename: David
authors.initials: D
authors.lastname: Soto
authors.forename: Paul
authors.initials: P
authors.lastname: Bentley
mesh_terms: D000328:Adult; D000368:Aged; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time; D020521:Stroke / Q000473:pathology*
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