title: Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis.
authors.affiliation: Latvian Institute of Organic Synthesis, Riga, Latvia; Riga Stradins University, Riga, Latvia.
authors.forename: Maija
authors.initials: M
authors.lastname: Dambrova
authors.forename: Elina
authors.initials: E
authors.lastname: Skapare-Makarova
authors.forename: Ilze
authors.initials: I
authors.lastname: Konrade
authors.forename: Osvalds
authors.initials: O
authors.lastname: Pugovics
authors.forename: Solveiga
authors.initials: S
authors.lastname: Grinberga
authors.forename: Dace
authors.initials: D
authors.lastname: Tirzite
authors.forename: Ramona
authors.initials: R
authors.lastname: Petrovska
authors.forename: Ivars
authors.initials: I
authors.lastname: Kalvins
authors.forename: Edgars
authors.initials: E
authors.lastname: Liepins
mesh_terms: D000328:Adult; D050197:Atherosclerosis; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002331:Carnitine / Q000378:metabolism; D004032:Diet; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D008744:Methylamines / Q000097:blood* / Q000652:urine; D008763:Methylhydrazines / Q000494:pharmacology*; D027701:Organic Cation Transport Proteins / Q000378:metabolism; D017747:Seafood; D000074058:Solute Carrier Family 22 Member 5
chemical_list: D002317:Cardiovascular Agents; D008744:Methylamines; D008763:Methylhydrazines; D027701:Organic Cation Transport Proteins; C492020:SLC22A5 protein, human; D000074058:Solute Carrier Family 22 Member 5; C050147:3-(2,2,2-trimethylhydrazine)propionate; C005855:trimethyloxamine; D002331:Carnitine
keywords: UPLC/MS/MS; meldonium; trimethylamine; trimethylamine N-oxide; urinary excretion