title: Linear and micronodular neuroendocrine cell hyperplasia in an ovarian mucinous cystadenoma.
abstract: We report a rare case of an ovarian mucinous cystadenoma in which there were peculiar neuroendocrine micronests composed of gastrin-immunoreactive cells. There was no clinical evidence of hypergastrinemia. The mucinous component of the neoplasm was represented by columnar cells mostly expressing a gastric phenotype with MUC5AC and claudin 18 positivity, which was consistent with the presence of interspersed gastrin cells. The tumoral stroma displayed areas of luteinization with cells intensely positive for α-inhibin, MART-1 and calretinin.
authors.affiliation: Surgical Pathology Division, Department of Laboratory, A. Manzoni Hospital, Lecco, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Dainese
authors.forename: Laura
authors.initials: L
authors.lastname: Cimetti
authors.forename: Carlo
authors.initials: C
authors.lastname: Capella
authors.forename: Cristina
authors.initials: C
authors.lastname: Riva
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D018291:Cystadenoma, Mucinous / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005755:Gastrins / Q000096:biosynthesis; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008875:Middle Aged; D055099:Neuroendocrine Cells / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D005755:Gastrins
keywords: Gastric foveolar differentiation; Gastrin cells; Neuroendocrine micronests; Ovarian mucinous cystadenoma; Stromal luteinization