title: Umbilical cord blood IL-6 as predictor of early-onset neonatal sepsis in women with preterm prelabour rupture of membranes.
abstract: OBJECTIVE
  To evaluate umbilical cord interleukin (IL)-6 and funisitis as independent predictors of early-onset neonatal sepsis (EONS) in preterm prelabor rupture of membranes (PPROM).
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Evaluation of umbilical cord IL-6 and funisitis as predictors of early-onset neonatal sepsis in PPROM.
  
  
  METHODS
  176 women with PPROM between 23+0-36+6 weeks of gestation.
  
  
  METHODS
  Umbilical cord IL-6 was assayed by ELISA. Funisitis was defined according to the Salafia classification. Data was adjusted by gestational age at delivery and prenatal administration of corticosteroids and antibiotics.
  
  
  METHODS
  Binary logistic regression was performed to assess the independence of umbilical cord IL-6 and funisitis to predict EONS in women complicated with PPROM.
  
  
  RESULTS
  The rate of EONS was 7%. Funisitis was present in 18% of women. Umbilical cord IL-6 was significantly higher in women complicated with EONS than without [median (range) 389.5 pg/mL (13.9-734.8) vs 5.2 (0.1-801-4), p<0.001]. Umbilical cord IL-6 was the only independent predictor of early-onset neonatal sepsis (odds ratio 13.6, p = 0.004).
  
  
  CONCLUSIONS
  Umbilical cord IL-6 was the only predictor of early-onset neonatal sepsis in PPROM. Contrary to what is reported, funisitis was not.
authors.affiliation: Maternal Fetal Medicine Department, Hospital Clinic, Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. tcobo@clinic.ub.es
authors.forename: Teresa
authors.initials: T
authors.lastname: Cobo
authors.forename: Marian
authors.initials: M
authors.lastname: Kacerovsky
authors.forename: Ctirad
authors.initials: C
authors.lastname: Andrys
authors.forename: Marcela
authors.initials: M
authors.lastname: Drahosova
authors.forename: Ivana
authors.initials: I
authors.lastname: Musilova
authors.forename: Helena
authors.initials: H
authors.lastname: Hornychova
authors.forename: Bo
authors.initials: B
authors.lastname: Jacobsson
mesh_terms: D000328:Adult; D002821:Chorioamnionitis / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies; D018805:Sepsis / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015850:Interleukin-6
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