title: Subarachnoid hemorrhage and cerebral vasospasm - literature review.
abstract: Subarachnoid hemorrhage represents a serious disease with high mortality and morbidity. Two important areas are becoming the central research interest of subarachnoid hemorrhage: cerebral vasospasm and early brain injury. The authors have reviewed the major contributions in experimental subarachnoid hemorrhage documented in the medical literature in the past 5 years. Treatments interfering with nitric oxide - or endothelin-pathways continue to show antispasmotic effects in experimental models of subarachnoid hemorrhage. Inflammation and oxidative stress play a vital role in the pathophysiology of cerebral vasospasm. Apoptosis, a relevant cause of early brain injury after subarachnoid hemorrhage, also underline the etiology of cerebral vasospasm. Future research studies will continue to elucidate the pathophysiological pathways and treatment modalities targeting cerebral vasospasm and early brain injury, enabling an improvement in outcome for patients with subarachnoid hemorrhage.
authors.affiliation: Neurosurgery Clinic, Bagdasar-Arseni Emergency Hospital, Bucharest, Romania.
authors.forename: A V
authors.initials: AV
authors.lastname: Ciurea
authors.forename: C
authors.initials: C
authors.lastname: Palade
authors.forename: D
authors.initials: D
authors.lastname: Voinescu
authors.forename: D A
authors.initials: DA
authors.lastname: Nica
mesh_terms: D017209:Apoptosis / Q000502:physiology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D009609:Nitrous Oxide / Q000378:metabolism; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology*; D020301:Vasospasm, Intracranial / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D051793:Hypoxia-Inducible Factor 1; D009609:Nitrous Oxide
keywords: Apoptosis; Early brain injury; Hypoxia induced factor-1; Nitrous oxide
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