title: Carbon nanotubes as vaccine scaffolds.
abstract: Carbon nanotubes display characteristics that are potentially useful in their development as scaffolds for vaccine compositions. These features include stability in vivo, lack of intrinsic immunogenicity, low toxicity, and the ability to be appended with multiple copies of antigens. In addition, the particulate nature of carbon nanotubes and their unusual properties of rapid entry into antigen-presenting cells, such as dendritic cells, make them especially useful as carriers of antigens. Early attempts demonstrating carbon nanotube-based vaccines can be used in both infectious disease settings and cancer are promising.
authors.affiliation: Molecular Pharmacology and Chemistry Program, Departments of Medicine and Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. Electronic address: d-scheinberg@ski.mskcc.org.
authors.forename: David A
authors.initials: DA
authors.lastname: Scheinberg
authors.forename: Michael R
authors.initials: MR
authors.lastname: McDevitt
authors.forename: Tao
authors.initials: T
authors.lastname: Dao
authors.forename: J Justin
authors.initials: JJ
authors.lastname: Mulvey
authors.forename: Evan
authors.initials: E
authors.lastname: Feinberg
authors.forename: Simone
authors.initials: S
authors.lastname: Alidori
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology; D003141:Communicable Diseases / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D037742:Nanotubes, Carbon; D009369:Neoplasms / Q000276:immunology; D014612:Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000941:Antigens; D037742:Nanotubes, Carbon; D014612:Vaccines
keywords: Carbon nanotubes; adjuvants; antigen presenting cells; vaccines
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