title: Incidence of transfusion-related adverse reactions per patient reflects the potential risk of transfusion therapy in Japan.
abstract: OBJECTIVE
  To describe the frequency of adverse reactions (ARs) after transfusion on both per transfused patient and per transfused unit bases.
  
  
  METHODS
  We performed a retrospective analysis of data available from records of 6 hospitals on the total number of transfusions and documented ARs between January 2008 and December 2009 for RBCs, fresh-frozen plasma (FFP), and platelet concentrates (PCs).
  
  
  RESULTS
  The incidence of ARs to RBCs, FFP, and PCs per transfused unit was 0.6%, 1.3%, and 3.8%, respectively. The incidence of ARs to RBCs, FFP, and PCs per patient was 2.6%, 4.3%, and 13.2%, respectively-almost 3-fold higher. Most RBC-ARs were febrile nonhemolytic transfusion reactions and allergic reactions, whereas most FFP-ARs and PC-ARs were allergic reactions.
  
  
  CONCLUSIONS
  The incidence of ARs per transfused patient may reflect better the potential risk of transfusion with blood components, taking into account the characteristics of the transfused patient.
authors.affiliation: Department of Transfusion Medicine, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan. hkato@aichi-med-u.ac.jp
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Kato
authors.forename: Motoaki
authors.initials: M
authors.lastname: Uruma
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujita
authors.forename: Makoto
authors.initials: M
authors.lastname: Handa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tomiyama
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Shimodaira
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kurata
authors.forename: Shigeru
authors.initials: S
authors.lastname: Takamoto
mesh_terms: D005334:Fever / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000209:etiology; D015994:Incidence; D007564:Japan; D009325:Nausea / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D065227:Transfusion Reaction
keywords: Adverse reactions; Hemovigilance; Per transfused patient basis; Transfusion practices