title: Higher serum levels of rheumatoid factor and anti-nuclear antibodies in helicobacter pylori-infected peptic ulcer patients.
abstract: OBJECTIVE
  H. pylori infection has been associated with some autoimmune disorders. The aim of this study was to evaluate the serum concentrations of rheumatoid factor and anti-nuclear antibodies in H. pylori-infected peptic ulcer patients, H. pylori-infected asymptomatic carriers and a healthy control group.
  
  
  METHODS
  A Total of 100 H. pylori-infected peptic ulcer patients, 65 asymptomatic carriers and 30 healthy H. pylori-negative subjects (as a control group) were enrolled into study. Serum samples of participants tested for the levels of rheumatoid factor and anti-nuclear antibodies by use of ELISA.
  
  
  RESULTS
  The mean serum levels of rheumatoid factor and anti-nuclear antibodies in peptic ulcer group was significantly higher in comparison to the control group (p<0.05). Although, the mean serum levels of rheumatoid factor and anti-nuclear antibodies in the asymptomatic carriers group was higher than those in the control group, the difference was not statistically significant. No significant differences were observed between peptic ulcer patients and asymptomatic carriers groups regarding the mean serum levels of rheumatoid factor and anti-nuclear antibodies. The mean serum levels of rheumatoid factor in men with peptic ulcer was significantly higher compared to the group of healthy men (p<0.05). Although in female of peptic ulcer patients or asymptomatic carriers groups, the mean serum levels of rheumatoid factor was higher than that in healthy women, but the differences were not statistically significant. Also, no significant differences were observed between men and women with peptic ulcer, asymptomatic carriers control groups based on the serum levels of anti-nuclear antibodies.
  
  
  CONCLUSIONS
  The results showed higher serum levels of rheumatoid factor and anti-nuclear antibodies in H. pylori-infected patients with peptic ulcer disease which represent the H. pylori-related immune disturbance in these patients. Additional follow-up studies are necessary to clarify the clinical significance of these autoantibodies in patients with H. pylori infection.
authors.affiliation: Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Microbiology and Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Abdollah
authors.initials: A
authors.lastname: Jafarzadeh
authors.forename: Maryam
authors.initials: M
authors.lastname: Nemati
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Rezayati
authors.forename: Mansooreh
authors.initials: M
authors.lastname: Nabizadeh
authors.forename: Medhi
authors.initials: M
authors.lastname: Ebrahimi
keywords: Anti-nuclear antibody; Helicobacter pylori; Peptic ulcer; Rheumatoid factor
references.citation: Expert Rev Clin Immunol. 2010 Sep;6(5):721-33
references.pmid: 20828280
references.citation: Autoimmun Rev. 2008 Feb;7(4):322-30
references.pmid: 18295738
references.citation: J Gastrointest Cancer. 2009;40(3-4):83-90
references.pmid: 19859834
references.citation: Curr Opin Rheumatol. 2004 May;16(3):246-53
references.pmid: 15103252
references.citation: Int J Infect Dis. 2009 Sep;13(5):647-54
references.pmid: 19233700
references.citation: J Autoimmun. 2009 Nov-Dec;33(3-4):290-9
references.pmid: 19682858
references.citation: Endocrinology. 2008 Sep;149(9):4554-66
references.pmid: 18499763
references.citation: J Clin Endocrinol Metab. 2006 Jan;91(1):176-9
references.pmid: 16263823
references.citation: Helicobacter. 2009 Sep;14 Suppl 1:15-20
references.pmid: 19712163
references.citation: Clin Endocrinol (Oxf). 2004 Nov;61(5):650-2
references.pmid: 15521972
references.citation: Oral Dis. 2011 Oct;17(7):621-7
references.pmid: 21902767
references.citation: Immunobiology. 2011 Dec;216(12):1256-63
references.pmid: 21840621
references.citation: Med Hypotheses. 2005;64(1):41-3
references.pmid: 15533608
references.citation: PLoS One. 2008;3(11):e3751
references.pmid: 19015732
references.citation: Helicobacter. 2011 Sep;16 Suppl 1:19-25
references.pmid: 21896081
references.citation: Int J Epidemiol. 1996 Jun;25(3):638-43
references.pmid: 8671567
references.citation: BMC Cancer. 2010 Aug 11;10:419
references.pmid: 20699000
references.citation: Autoimmune Dis. 2011;2011:815038
references.pmid: 21915375
references.citation: Infect Immun. 2006 Jan;74(1):248-56
references.pmid: 16368978
references.citation: Clin Exp Rheumatol. 2008 Jul-Aug;26(4):627-31
references.pmid: 18799094
references.citation: Recenti Prog Med. 2000 Apr;91(4):175-80
references.pmid: 10804750
references.citation: Arthritis Res Ther. 2008;10(5):218
references.pmid: 18947369
references.citation: Aliment Pharmacol Ther. 2002 Jul;16(7):1291-9
references.pmid: 12144579
references.citation: Diabetol Metab Syndr. 2011 Oct 26;3(1):28
references.pmid: 22029731
references.citation: J Physiol Pharmacol. 2004 Jul;55 Suppl 2:91-104
references.pmid: 15608364
references.citation: Indian J Med Microbiol. 2008 Apr-Jun;26(2):127-31
references.pmid: 18445947
references.citation: Saudi Med J. 2005 Sep;26(9):1372-7
references.pmid: 16155650
references.citation: Singapore Med J. 2006 Apr;47(4):291-6
references.pmid: 16572240
references.citation: Expert Rev Gastroenterol Hepatol. 2008 Aug;2(4):577-85
references.pmid: 19072405
references.citation: World J Gastroenterol. 2007 Jun 14;13(22):3117-21
references.pmid: 17589930
references.citation: Infect Immun. 2011 Dec;79(12):4791-801
references.pmid: 21947775
references.citation: Clin Microbiol Rev. 2006 Jul;19(3):449-90
references.pmid: 16847081
references.citation: Recenti Prog Med. 2010 Jan;101(1):27-33
references.pmid: 20391683
references.citation: Oman Med J. 2009 Jul;24(3):208-11
references.pmid: 22224187
references.citation: Kansenshogaku Zasshi. 2010 Jan;84(1):1-8
references.pmid: 20170006