title: [Prolonged curarisation following succinylcholine injection on butyrylcholinesterase deficiency and potentiated by a lithium treatment: a case report].
abstract: Succinylcholine is a short-term curare which degradation depends on its quick hydrolysis by butyrylcholinesterase (or pseudocholinesterase). Thus, a butyrycholinesterase deficiency, congenital or acquired, is a cause of a prolonged neuromuscular block. From an autosomal recessive inheritance, genetic deficiency remains the first etiology. The most frequently discussed variant is the atypical variant which caused a 2 hours prolonged curarisation after administration of succinylcholine. We report a patient who had a prolonged curarisation after succinylcholine's injection, due to a congenital butyrylcholinestérase deficiency and contributed by a lithium treatment. Extubation was only possible 7 hours after administration of curare.
authors.affiliation: Fédération d'anesthésie, réanimation et des urgences, Hôpital d'instruction des armées Clermont-Tonnerre, Brest, France. sophiehuynh@gmail.com
authors.forename: Sophie
authors.initials: S
authors.lastname: Huynh-Moynot
authors.forename: Jean-Clair
authors.initials: JC
authors.lastname: Moynot
authors.forename: Chloé
authors.initials: C
authors.lastname: Thill
authors.forename: Diane
authors.initials: D
authors.lastname: Commandeur
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ould-Ahmed
authors.forename: Isabelle
authors.initials: I
authors.lastname: Drouillard
mesh_terms: D000368:Aged; D001049:Apnea; D001714:Bipolar Disorder / Q000188:drug therapy; D001999:Bronchoscopy / Q000379:methods; D002091:Butyrylcholinesterase / Q000172:deficiency; D004357:Drug Synergism; D006801:Humans; D007442:Intubation, Intratracheal; D018020:Lithium Compounds / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000175:diagnosis; D008297:Male; D008661:Metabolism, Inborn Errors / Q000150:complications*; D019148:Neuromuscular Blockade / Q000009:adverse effects*; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects*; D013390:Succinylcholine / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D018020:Lithium Compounds; D009467:Neuromuscular Depolarizing Agents; D002091:Butyrylcholinesterase; D013390:Succinylcholine
keywords: butyrylcholinesterase; lithium; paraneoplastic syndrome; pseudocholinesterase; sevoflurane