title: Pulsed electrodeposition for the synthesis of strontium-substituted calcium phosphate coatings with improved dissolution properties.
abstract: Strontium-substituted calcium phosphate coatings are synthesized by pulsed electrodeposition on titanium alloy (Ti6Al4V) substrates. Experimental conditions of the process are optimized in order to obtain a coating with a 5% atomic substitution of calcium by strontium which corresponds to the best observations on the osteoblast cells activity and on the osteoclast cells proliferation. The physical and chemical characterizations of the obtained coating are carried out by scanning electron microscopy associated to energy dispersive X-ray spectroscopy (EDXS) for X-ray microanalysis and the structural characterization of the coating is carried out by X-ray diffraction. The in vitro dissolution/precipitation properties of the coated substrates are investigated by immersion into Dulbecco's Modified Eagle Medium (DMEM) from 1h to 14 days. The calcium, phosphorus and strontium concentrations variations in the biological liquid are assessed by Induced Coupled Plasma - Atomic Emission Spectroscopy for each immersion time. The results show that under specific experimental conditions, the electrodeposition process is suitable to synthesize strontium-substituted calcium phosphate coatings. Moreover, the addition of hydrogen peroxide (H2O2) into the electrolytic solution used in the process allows us to observe a control of the strontium release during the immersion of the prosthetic materials into DMEM.
authors.affiliation: LISM EA 4695, Université de Reims Champagne-Ardenne, 21 rue Clément ADER, 51685 Reims, BP 138 Cedex 02, France. richard.drevet@univ-reims.fr
authors.forename: Richard
authors.initials: R
authors.lastname: Drevet
authors.forename: Hicham
authors.initials: H
authors.lastname: Benhayoune
mesh_terms: D002118:Calcium / Q000032:analysis; D002130:Calcium Phosphates / Q000138:chemical synthesis*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D004560:Electricity; D004595:Electroplating / Q000379:methods*; D006861:Hydrogen Peroxide / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010758:Phosphorus / Q000032:analysis; D013052:Spectrometry, X-Ray Emission; D013324:Strontium / Q000032:analysis / Q000737:chemistry*; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D010758:Phosphorus; C020243:calcium phosphate; D006861:Hydrogen Peroxide; D002118:Calcium; D013324:Strontium
keywords: Biomaterial; Calcium phosphate coating; Electrodeposition; Physiological solution; Strontium substitution; Titanium alloy