title: Host-pathogen interaction in HIV infection.
abstract: The host-pathogen interaction is strikingly complex during HIV infection. While several immune effector mechanisms (i.e. cytotoxic T cells, neutralizing antibodies, NK cells, among others) can play a strong antiviral role in vivo, the virus is remarkably able to evade these responses. In addition, the virus preferentially infects and kills activated memory CD4+ T cells, thus exploiting the host antiviral immune response as a source of new cellular targets for infection. Recent advances in understanding (i) how HIV perturbs the host immune system, (ii) how the immune system fights HIV; and (iii) how HIV disease persists when virus replication is suppressed by antiretroviral drugs may hopefully lead to better prevention and treatment strategies for this deadly viral infection.
authors.affiliation: Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.
authors.forename: Ankita
authors.initials: A
authors.lastname: Chowdhury
authors.forename: Guido
authors.initials: G
authors.lastname: Silvestri
mesh_terms: D000375:Aging; D000818:Animals; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D016662:Virus Integration; D014779:Virus Replication
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