title: ENCODE and a new landscape for psychiatric genetics.
abstract: Despite rigorous research into the genetics of neuropsychiatric disorders, the mechanism by which polygenic risk leads to complex clinical phenotypes remains unclear. The Encyclopedia of DNA Elements (ENCODE) project gives us new insight into gene regulation, and gene-gene and gene-environment interaction. Better understanding of these key genomic mechanisms may provide the answers we have been searching for.
authors.forename: Akshay
authors.initials: A
authors.lastname: Nair
authors.forename: Robert
authors.initials: R
authors.lastname: Howard
mesh_terms: D030541:Databases, Genetic; D005786:Gene Expression Regulation; D059647:Gene-Environment Interaction; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*