title: Association of serum uric acid with proteinuria in type 2 diabetic patients.
abstract: BACKGROUND
  Various findings suggest that uric acid is an inflammatory factor and may have a role in endothelial dysfunction and act as a mediator of diabetic nephropathy. The objective of this study was to evaluate the relationships between serum uric acid level and level of proteinuria in type 2 diabetic (T2D) patients.
  
  
  METHODS
  A cross-sectional analytical study was conducted in 60 patients with T2D without a history of gout. None was treated with allopurinol. Venous blood samples were obtained in fasting state for determinations of serum creatinine, uric acid, and hemoglobin A1c (HbA1c) (reference range 3.8-5.5%); 24-h urine proteinuria was also measured.
  
  
  RESULTS
  Mean age of the patients was 57 ± 8.3 years. Mean ± standard error (SE) of serum creatinine was 0.98 ± 0.028 mg/dL, mean ± SE of serum uric acid was 4.5 ± 0.15 mg/dL, and mean ± SE of proteinuria was 388 ± 28.7 mg/day (median = 303.5 mg/day). There was no significant difference in serum uric acid, HbA1c, and creatinine level between males and females (P > 0.05). There was a significant positive association between body mass index (BMI) and serum uric acid levels (r = 0.428, P = 0.001). After adjustment for weight, a significant positive association of serum uric acid with level of proteinuria was seen (r = 0.47, P < 0.001).
  
  
  CONCLUSIONS
  Serum uric acid had a significant positive association with diabetic nephropathy. It might be hypothesized that serum uric acid plays a role in diabetic nephropathy in T2D.
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Behradmanesh
authors.forename: Mohammad Karami
authors.initials: MK
authors.lastname: Horestani
authors.forename: Azar
authors.initials: A
authors.lastname: Baradaran
authors.forename: Hamid
authors.initials: H
authors.lastname: Nasri
keywords: Proteinuria; renal failure; type 2 diabetes mellitus; uric acid
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