title: Synthesis of temperature-dependent elastin-like peptide-modified dendrimer for drug delivery.
abstract: Dendrimers are synthetic macromolecules with a unique structure that are potential unimolecular drug carriers and potential scaffolds for peptides. Elastin is one of the main components of the extracellular matrix, as well as a temperature-sensitive biomacromolecule. Val-Pro-Gly-Val-Gly repeats, an elastin-like peptide, have been used for designing artificial elastin molecules. In this study, we have synthesized a novel type of temperature-dependent drug carrier by conjugating Ac-Val-Pro-Gly-Val-Gly to a dendrimer, named elastin-mimetic dendrimer. The elastin-mimetic dendrimer formed β-turn structure by heating. The elastin-mimetic dendrimer exhibited the inverse phase transition, depending on pH and NaCl concentration in addition to temperature. The elastin-mimetic dendrimer could encapsulate a model drug, rose bengal, even though the complex stability was similar to the dendrimer without elastin-like peptide. Therefore, the elastin-mimetic dendrimer is a potential drug carrier with temperature- and pH-dependent properties.
authors.affiliation: Nanoscience and Nanotechnology Research Center, Research Organization for the 21st Century, Osaka Prefecture University, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Kojima
authors.forename: Kotaro
authors.initials: K
authors.lastname: Irie
mesh_terms: D050091:Dendrimers / Q000737:chemistry; D004337:Drug Carriers; D004549:Elastin / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D013696:Temperature
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D010455:Peptides; D004549:Elastin
keywords: dendrimer; drug delivery; elastin; pH; peptide; temperature-sensitive