title: [New treatment for sepsis: stem cell therapy].
abstract: Sepsis is the systemic inflammatory response to infection and a major cause of mortality in critical patients. The severe disorder of immune system is the common pathophysiological changes in septic patients. Mesenchymal stem cells (MSCs) have shown great immunoloregulation properties in recent studies. It can increase the level of IL-10, an anti-inflammatory cytokine, promote the secretion of prostaglandin E2 (PGE2), indolamine 2,3-dioxygenase (IDO), and regulate the proliferation, differentiation and function of the immune cells such as mononuclear macrophage, t-lymphocytes, natural killer cells and so on. MSCs may provide new ideas for the treatment of sepsis.
authors.affiliation: Critical Medicine Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Shangping
authors.initials: S
authors.lastname: Zhao
authors.forename: Mingshi
authors.initials: M
authors.lastname: Yang
mesh_terms: D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology; D018805:Sepsis / Q000276:immunology* / Q000628:therapy*