title: Chemopreventive effects of combination of honokiol and magnolol with α-santalol on skin cancer developments.
abstract: α-Santalol is active component of sandalwood oil and has been shown to have chemopreventive effects against chemically and UVB-induced skin cancer development in mice. α-Santalol is also shown to have skin permeation enhancing effects. Honokiol and magnolol isolated from Magnolia officinalis bark extract have also been shown to have chemopreventive effects against chemically and UVB-induced skin cancer in mice. This study was conducted to investigate the combination effects of α-santalol, honokiol and magnolol to study any additive/synergistic effects to lower the doses required for chemoprevention. Pretreatment of combinations of α-santalol with honokiol and magnolol significantly decreased tumor multiplicity upto 75% than control, α-santalol, honokiol and magnolol alone in SKH-1 mice. Combination of α-santalol with honokiol and magnolol also decreased cell viability, proliferation, and enhanced apotosis in comparison to α-santalol, honokiol and magnolol alone in Human epidrmoid carcinoma A431 cells. Overall, the results of present study indicated combinations of α-santalol with honokiol and magnolol could provide chemoprevention of skin cancer at lower doses than given alone.
authors.affiliation: Departments of Pharmaceutical Sciences, South Dakota State University, Brookings, SD, USA.
authors.forename: C
authors.initials: C
authors.lastname: Chilampalli
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: R S
authors.initials: RS
authors.lastname: Kaushik
authors.forename: A
authors.initials: A
authors.lastname: Young
authors.forename: D
authors.initials: D
authors.lastname: Zeman
authors.forename: M B
authors.initials: MB
authors.lastname: Hildreth
authors.forename: H
authors.initials: H
authors.lastname: Fahmy
authors.forename: C
authors.initials: C
authors.lastname: Dwivedi
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects; D001713:Biphenyl Compounds / Q000008:administration & dosage*; D049109:Cell Proliferation / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D017705:Lignans / Q000008:administration & dosage*; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000008:administration & dosage*; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control*; D014466:Ultraviolet Rays; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D016588:Anticarcinogenic Agents; D001713:Biphenyl Compounds; D017705:Lignans; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols; C043206:santalol