title: The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma.
abstract: BACKGROUND
  Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expression in both HCC and matched adjacent non-tumor tissue.
  
  
  METHODS
  Sixty-three patients with HCC who underwent hepatic resection were enrolled in this study. Aurora B expression in tumor and non-tumor tissue was examined by use of quantitative reverse transcription-polymerase chain reaction. The patients were divided into high and low gene expression groups by median value, and clinicopathological data were compared between the two groups.
  
  
  RESULTS
  Aurora B expression was significantly higher in tumor tissue than in non-cancerous tissue (P < 0.001). Disease-free survival was not significantly different between groups with high and low expression in the tumor tissues. For non-tumor tissues, disease-free survival of the low-expression group was significantly better than that of the high-expression group (P < 0.05). The gene expression level of Aurora B correlated with results from liver function tests, for example prothrombin time.
  
  
  CONCLUSIONS
  Aurora B expression in non-cancerous tissues may be a prognostic factor for HCC.
authors.affiliation: Department of Surgery, The University of Tokushima, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
authors.forename: Lkhagva-Ochir
authors.initials: LO
authors.lastname: Tovuu
authors.forename: Tohru
authors.initials: T
authors.lastname: Utsunomiya
authors.forename: Satoru
authors.initials: S
authors.lastname: Imura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Morine
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ikemoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Mori
authors.forename: Jun
authors.initials: J
authors.lastname: Hanaoka
authors.forename: Mami
authors.initials: M
authors.lastname: Kanamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Yu
authors.initials: Y
authors.lastname: Saito
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yamada
authors.forename: Michihito
authors.initials: M
authors.lastname: Asanoma
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D064107:Aurora Kinase B / Q000096:biosynthesis* / Q000235:genetics; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011517:Prothrombin Time
chemical_list: D014408:Biomarkers, Tumor; C576921:AURKB protein, human; D064107:Aurora Kinase B
references.citation: J Hepatol. 2009 Mar;50(3):518-27
references.pmid: 19155085
references.citation: Oncogene. 2005 Nov 10;24(49):7266-72
references.pmid: 16027732
references.citation: Cancer Res. 1998 Nov 1;58(21):4811-6
references.pmid: 9809983
references.citation: Eur J Obstet Gynecol Reprod Biol. 2009 Jan;142(1):57-63
references.pmid: 19059698
references.citation: J Hepatol. 2010 Jan;52(1):63-71
references.pmid: 19913935
references.citation: Mol Cancer Ther. 2006 Nov;5(11):2905-13
references.pmid: 17121938
references.citation: Virchows Arch. 2007 Mar;450(3):297-302
references.pmid: 17235564
references.citation: Nat Rev Mol Cell Biol. 2007 Oct;8(10):798-812
references.pmid: 17848966
references.citation: Curr Opin Cell Biol. 2009 Feb;21(1):51-8
references.pmid: 19185479
references.citation: Mol Cancer Res. 2007 Jan;5(1):1-10
references.pmid: 17259342
references.citation: Int J Clin Oncol. 2013 Aug;18(4):651-6
references.pmid: 22706704
references.citation: J Gastroenterol. 2010 Feb;45(2):146-52
references.pmid: 19997856
references.citation: N Engl J Med. 2011 Sep 22;365(12):1118-27
references.pmid: 21992124
references.citation: Biochim Biophys Acta. 2008 Sep;1786(1):60-72
references.pmid: 18662747
references.citation: Lancet. 2003 Dec 6;362(9399):1907-17
references.pmid: 14667750
references.citation: BMC Cancer. 2010 Aug 28;10:461
references.pmid: 20799978
references.citation: Br J Surg. 2008 May;95(5):611-9
references.pmid: 18311747
references.citation: Cancer Res. 2002 Sep 15;62(18):5168-77
references.pmid: 12234980
references.citation: Virchows Arch. 2009 Nov;455(5):431-40
references.pmid: 19838728
references.citation: Prostate. 2006 Feb 15;66(3):326-33
references.pmid: 16267859
references.citation: Cancer Sci. 2009 Mar;100(3):472-80
references.pmid: 19134008
references.citation: J Clin Oncol. 2009 Mar 20;27(9):1485-91
references.pmid: 19224838