title: How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study.
abstract: The impact of calcification on the carotid atherosclerotic plaque vulnerability remains controversial and unclear. This study assesses the critical mechanical conditions induced by the calcium at the lumen surface, i.e., juxtaluminal calcification (JLCa), within human carotid atherosclerotic plaque. Eleven patients with evidence of JLCa were included for the analysis. The plaque geometry was reconstructed based on computed tomography and magnetic resonance images and 3-D fluid-structure interaction simulation was used for mechanical analysis. The presence of JLCa increased local stresses compared to when calcification was artificially covered with a 0.2-mm-thick fibrous cap (107.87 kPa [76.99, 129.14] versus 63.17 kPa [34.55, 75.13]; Median, [interquartile range]; ). Stretch ratio decreased from 1.18 [1.07, 1.27] to 1.13 [1.10, 1.18] (p = 0.03). The presence of JLCa significantly elevates local stress and stretch level. Further exploration of this plaque feature is warranted as a possible risk factor causing plaque vulnerability.
authors.lastname: Zhongzhao Teng
authors.lastname: Jing He
authors.forename: Umar
authors.initials: U
authors.lastname: Sadat
authors.forename: John R
authors.initials: JR
authors.lastname: Mercer
authors.lastname: Xiaoyan Wang
authors.forename: Nasim S
authors.initials: NS
authors.lastname: Bahaei
authors.forename: Owen M
authors.initials: OM
authors.lastname: Thomas
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Gillard
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000503:physiopathology; D001696:Biomechanical Phenomena / Q000502:physiology; D002114:Calcinosis / Q000503:physiopathology*; D002118:Calcium; D016893:Carotid Stenosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D058226:Plaque, Atherosclerotic / Q000473:pathology / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed
chemical_list: D002118:Calcium