title: Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor.
abstract: We describe an electrochemical analog of fluorescence polarization that supports the quantitative measurement of a specific protein, the chemokine IP-10, directly in undiluted blood serum. The sensor is label-free, wash-free, and electronic, suggesting it could support point-of-care detection of diagnostic proteins in largely unprocessed clinical samples.
authors.affiliation: Department of Chemistry, Metropolitan State University of Denver, Denver, CO 80217, USA. abonham@msudenver.edu.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Bonham
authors.forename: Nicole G
authors.initials: NG
authors.lastname: Paden
authors.forename: Francesco
authors.initials: F
authors.lastname: Ricci
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Plaxco
mesh_terms: D015415:Biomarkers / Q000097:blood; D054357:Chemokine CXCL10 / Q000032:analysis* / Q000097:blood; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D055664:Electrochemical Techniques / Q000379:methods*; D006801:Humans; D017433:Protein Structure, Secondary; D044967:Serum / Q000737:chemistry* / Q000378:metabolism
chemical_list: D015415:Biomarkers; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D004247:DNA
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