title: Bariatric surgery decreases carotid intima-media thickness in obese subjects.
abstract: BACKGROUND
  Obesity has long been associated with an increased risk of cardiovascular disease (CVD). The aim of this study was to evaluate the impact of substantial weight loss induced by bariatric surgery on carotid intima media thickness (C-IMT) (surrogate marker of early atherosclerosis) and classic factors of cardiovascular risk (CVRFs).
  
  
  METHODS
  thirty-one obesity patients were evaluated for bariatric surgery. Twenty-seven were undergone surgery, 14 Roux-en-Y gastric bypass surgery (GBS) and 13 sleeve gastrectomy. The four obese patients who did not undergo surgery, were performed the same evaluations.
  
  
  METHODS
  Body weight, BMI, blood pressure, total cholesterol, TC levels, LDL-C, HDL-C, TG, fasting plasma glucose and insulin, HOMA IR, and US B-mode C-IMT was measured.
  
  
  RESULTS
  After 354 ± 92 days follow up, 27 patients that underwent bariatric surgery evidenced a mean body mass index decrease from 38 to 27 k/m² (p < 0.001), simultaneously was observed improvement in CVRFs, 10 years Framingham risk and a significant reduction of therapeutic requirements. C-IMT diminished from a mean of 0.58 ± 0.14 mm to 0.49 ± 0.09 mm (p = 0.0001). Four patients that did not undergo surgery increased C-IMT from 0.52 ± 0.12 to 0.58 ± 0.13 mm (p = 0.03) with no significant changes in CVRFs.
  
  
  CONCLUSIONS
  Weight loss, one year after bariatric surgery, GBS and sleeve gastrectomy, decreases C-IMT; improve CVRFs and 10 years Framingham risk.
authors.affiliation: Nutrition Department, Clínica Dávila, Chile. ggarciabravo@vtr.net
authors.forename: Gonzalo
authors.initials: G
authors.lastname: García
authors.forename: Daniel
authors.initials: D
authors.lastname: Bunout
authors.forename: Javiera
authors.initials: J
authors.lastname: Mella
authors.forename: Erik
authors.initials: E
authors.lastname: Quiroga
authors.forename: María Pía
authors.initials: MP
authors.lastname: de la Maza
authors.forename: Gabriel
authors.initials: G
authors.lastname: Cavada
authors.forename: Sandra
authors.initials: S
authors.lastname: Hirsch
mesh_terms: D000328:Adult; D000886:Anthropometry; D050110:Bariatric Surgery; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000000981:diagnostic imaging* / Q000601:surgery*; D011446:Prospective Studies; D018570:Risk Assessment; D016896:Treatment Outcome; D015431:Weight Loss; D055815:Young Adult
chemical_list: D007328:Insulin; D008055:Lipids