title: Protein resistance and pH-responsive controlled release from the modification of single-walled carbon nanotubes with a double polymer layer.
abstract: A reliable and easy method is developed to confer protein resistance and drug controlled release dual functions to single-walled carbon nanotubes (SWNTs) by modification with a polydopamine (Pdop) layer and poly(oligo(ethylene glycol) methacrylate) (POEGMA) brushes. The study of protein resistance demonstrates that POEGMA-modified SWNTs exhibit higher protein resistance than pristine SWNTs, and the protein resistance ability is dependant on the length of the POEGMA molecule. Furthermore, the Pdop layer can serve as a pH-responsive switch for controlled loading and release of rhodamine 6G. The integration of protein resistance and pH-responsive controlled release make the double-layer modified SWNTs attractive for drug delivery in cancer therapy.
authors.affiliation: School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi, 832003, China.
authors.forename: Guoxiang
authors.initials: G
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Jia
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Liu
authors.forename: Jiamei
authors.initials: J
authors.lastname: Hu
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Ma
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry*; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids; D012235:Rhodamines / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013818:Thermogravimetry
chemical_list: D003692:Delayed-Action Preparations; D007211:Indoles; D008689:Methacrylates; D037742:Nanotubes, Carbon; D011108:Polymers; D011109:Polymethacrylic Acids; D012235:Rhodamines; C528061:poly(poly(ethylene glycol)methacrylate); C568283:polydopamine; C026188:rhodamine 6G; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols
keywords: controlled release; pH-responsivity; protein resistance; single-walled carbon nanotubes; surface modification