title: A prospective, randomised study of a novel transforming methacrylate dressing compared with a silver-containing sodium carboxymethylcellulose dressing on partial-thickness skin graft donor sites in burn patients.
abstract: This prospective, randomised study compares a new transforming methacrylate dressing (TMD) with a silver-containing carboxymethylcellulose dressing (CMC-Ag) after application to split-thickness skin graft (STSG) donor sites. This was an unblinded, non-inferiority, between-patient, comparison study that involved patients admitted to a single-centre burn unit who required two skin graft donor sites. Each patient's donor sites were covered immediately after surgery: one donor site with TMD and the other with CMC-Ag. The donor sites were evaluated until healing or until 24 days post-application, whichever came first. Study endpoints were time to healing, daily pain scores, number of dressing changes, patient comfort and physicians' and patients' willingness to use the dressings in the future. Nineteen patients had both the dressings applied. No statistically significant difference was noted in time to healing between the two dressings (14·2 days using TMD compared with 13·2 days using CMC-Ag). When pain scores were compared, TMD resulted in statistically significantly less pain at three different time periods (2-5 days, 6-10 days and 11-15 days; P < 0·001 at all time periods). Patients also reported greater comfort with TMD (P < 0·001). Users rated TMD as being less easy to use because of the time and technique required for application. Reductions in pain and increased patient comfort with the use of the TMD dressing, compared with CMC-Ag, were seen as clinical benefits as these are the major issues in donor site management.
authors.affiliation: Department for Hospital Hygiene, Medical University of Vienna, Vienna General Hospital, Vienna, Austria.
authors.forename: Ojan
authors.initials: O
authors.lastname: Assadian
authors.affiliation: Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Brett
authors.initials: B
authors.lastname: Arnoldo
authors.affiliation: Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Purdue
authors.affiliation: Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Agnes
authors.initials: A
authors.lastname: Burris
authors.affiliation: Department for Vascular and Endovascular Surgery, Wilhelminen-Hospital, Vienna, Austria.
authors.forename: Edda
authors.initials: E
authors.lastname: Skrinjar
authors.affiliation: Department for Vascular and Endovascular Surgery, Wilhelminen-Hospital, Vienna, Austria.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Duschek
authors.affiliation: Department of Surgery, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Leaper
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002056:Burns / Q000628:therapy*; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D011446:Prospective Studies; D018030:Silver Compounds / Q000008:administration & dosage*; D016038:Skin Transplantation / Q000379:methods*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D060053:Transplant Donor Site / Q000601:surgery*; D014945:Wound Healing; D055815:Young Adult
chemical_list: D018030:Silver Compounds; D002266:Carboxymethylcellulose Sodium
keywords: Altrazeal; Burns; Carboxymethylcellulose dressing; Dressing change; Pain; Silver dressings; Split-thickness skin graft donor sites; Transforming methacrylate dressing
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