title: [Mid-term follow-up results of laparoscopic radiofrequency ablation for renal cell carcinoma of T1aN0M0 stage].
abstract: OBJECTIVE
  To determine the effect of laparoscopic radiofrequency ablation of T1aN0M0 renal cell carcinoma (RCC) with regular follow-up.
  
  
  METHODS
  All patients underwent surgery from March 2006 to March 2009. Eight cases were solitary kidney. Twenty-two cases of left RCC and 18 cases of right RCC were diagnozed by ultrasonography and CT scanning.All of the cases were T1aN0M0 stage. No metastasis was found by iconography test. By ultrasound positioning, laparoscopic radiofrequency were performed on the renal tumor. All patients were followed up with eGFR and enhanced-CT.
  
  
  RESULTS
  All patients underwent laparoscopic radiofrequency ablation surgery successfully. The mean operation time was (101 ± 19) minutes and the mean blood loss was (90 ± 14) ml (no blood transfusion pre- and post-operation). During postoperative follow-up, enhanced CT revealed complete ablation in 39 cases (the success rate was 97.5%), and 1 residue tumor was confirmed by enhanced CT 7 days post operation. This patient was under close surveillance because of solitary kidney. No progression of the residue tumor was found during the follow-up. One case of recurrence was confirmed by enhanced CT in 6 month after operation. The 3-year recurrence rate was 2.5%. No further intervation was performed on this patient and no change was found in the recurrence area during the follow-up. Both 3-year total survival rate and 3-year cancer specific survival rate were 100%. The mean eGFR was (72 ± 9) ml/(min·1.73 m(2)) in 3 years after surgery. There was no significant difference between pre-and post-operation (P > 0.05).
  
  
  CONCLUSIONS
  Mid-term follow-up results show the effectiveness and safety of laparoscopic radiofrequency ablation in the treatment for T1aN0M0 RCC and have no negative influence on the renal function.
authors.affiliation: Department of Urology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing 210008, China.
authors.forename: Jian-nan
authors.initials: JN
authors.lastname: Song
authors.forename: Xiao-zhi
authors.initials: XZ
authors.lastname: Zhao
authors.forename: Hui-bo
authors.initials: HB
authors.lastname: Lian
authors.forename: Guang-xiang
authors.initials: GX
authors.lastname: Liu
authors.forename: Xiao-gong
authors.initials: XG
authors.lastname: Li
authors.forename: Gu-tian
authors.initials: GT
authors.lastname: Zhang
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Gan
authors.forename: Hong-qian
authors.initials: HQ
authors.lastname: Guo
mesh_terms: D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000601:surgery*; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D016896:Treatment Outcome