title: A novel equilibrium relating to the helix handedness in G-quadruplexes formed by heterochiral oligonucleotides with an inversion of polarity site.
abstract: Investigations of heterochiral oligodeoxynucleotides 5'-TD1GD2GD3-3'-3'-GL3GL2TL1-5' (L33) and 3'-TD1GD2GD3-5'-5'-GL3GL2TL1-3' (L55) forming quadruplex structures are reported. Data indicate the presence of enantiomeric left- and right-handed quadruplex helices. In the case of L55, NMR experiments point to an unusual equilibrium between them.
authors.affiliation: Department of Pharmacy, University of Naples "Federico II", Via D. Montesano, 49, 80131 Naples, Italy. galeone@unina.it.
authors.forename: Antonella
authors.initials: A
authors.lastname: Virgilio
authors.forename: Veronica
authors.initials: V
authors.lastname: Esposito
authors.forename: Alfonso
authors.initials: A
authors.lastname: Mangoni
authors.forename: Luciano
authors.initials: L
authors.lastname: Mayol
authors.forename: Aldo
authors.initials: A
authors.lastname: Galeone
mesh_terms: D054856:G-Quadruplexes; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009841:Oligonucleotides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009841:Oligonucleotides