title: From micrograms to grams: scale-up synthesis of eribulin mesylate.
abstract: The synthesis of eribulin mesylate from microgram to multi-gram scale is described in this Highlight. Key coupling reactions include formation of the C30a to C1 carbon-carbon bond and macrocyclic ring closure through an intramolecular Nozaki-Hiyama-Kishi reaction.
authors.affiliation: Eisai Inc., Andover, MA, USA. Melvin_Yu@eisai.com
authors.forename: Melvin J
authors.initials: MJ
authors.lastname: Yu
authors.forename: Wanjun
authors.initials: W
authors.lastname: Zheng
authors.forename: Boris M
authors.initials: BM
authors.lastname: Seletsky
mesh_terms: D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D000095662:Polyether Polyketides
chemical_list: D005663:Furans; D007659:Ketones; C490954:eribulin; D000095662:Polyether Polyketides