title: Preservation of the native spleen in multivisceral transplantation.
abstract: The native spleen is usually removed in patients undergoing MTV. The consequential asplenic state is associated with a high risk of sepsis, especially in immunosuppressed children. In contrast, the inclusion of an allogeneic spleen in multivisceral grafts has been associated with a high incidence of GVHD. We propose an alternative technique for patients undergoing MTV, consisting of the preservation of the native spleen. This approach avoids the additional risk of infection that characterizes the asplenic state without the detrimental side effects of the allogeneic spleen.
authors.affiliation: Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain. fhernandezo.hulp@salud.madrid.org
authors.forename: F
authors.initials: F
authors.lastname: Hernandez
authors.forename: A M
authors.initials: AM
authors.lastname: Andres
authors.forename: J L
authors.initials: JL
authors.lastname: Encinas
authors.forename: E
authors.initials: E
authors.lastname: Domínguez
authors.forename: M
authors.initials: M
authors.lastname: Gamez
authors.forename: F J
authors.initials: FJ
authors.lastname: Murcia
authors.forename: N
authors.initials: N
authors.lastname: Leal
authors.forename: L
authors.initials: L
authors.lastname: Martinez
authors.forename: M
authors.initials: M
authors.lastname: Molina
authors.forename: E
authors.initials: E
authors.lastname: Ramos
authors.forename: J
authors.initials: J
authors.lastname: Sarria
authors.forename: E
authors.initials: E
authors.lastname: Martinez-Ojinaga
authors.forename: G
authors.initials: G
authors.lastname: Prieto
authors.forename: E
authors.initials: E
authors.lastname: Frauca
authors.forename: M
authors.initials: M
authors.lastname: Lopez-Santamaria
mesh_terms: D002675:Child, Preschool; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000628:therapy; D005260:Female; D005705:Gallbladder Diseases / Q000628:therapy; D006086:Graft vs Host Disease; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007409:Intestinal Atresia / Q000628:therapy; D007418:Intestinal Pseudo-Obstruction / Q000628:therapy; D008297:Male; D016377:Organ Transplantation / Q000379:methods*; D012306:Risk; D012778:Short Bowel Syndrome / Q000628:therapy; D013154:Spleen / Q000473:pathology / Q000601:surgery / Q000637:transplantation*; D013997:Time Factors; D014138:Tracheoesophageal Fistula / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents
keywords: children; multivisceral transplantation; retransplantation; spleen