title: Metaplastic mammary carcinoma with discrepant hormone receptor results by IHC and RT-PCR.
abstract: This is a young premenopausal woman with a T1cN0 metaplastic breast cancer that is ER/PR Allred score 3, but negative by mRNA. Our recommendations are: adjuvant chemotherapy with TAC x 6 or dose-dense doxorubicin and cyclophosphamide followed by paclitaxel (ddAC-T). Whole-breast radiation therapy would follow. The patient could try tamoxifen, although the likelihood of benefit is very small.
authors.affiliation: Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Elias
authors.forename: Sharon
authors.initials: S
authors.lastname: Sams
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009362:Neoplasm Metastasis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods*
chemical_list: D018394:CA-125 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human