title: Risk stratification in critically ill patients: GDF-15 scores in adult respiratory distress syndrome.
abstract: Patients with adult respiratory distress syndrome (ARDS) are highly heterogeneous but current therapies are rather uniform and largely supportive. In the previous issue of Critical Care, Clark and colleagues report that the biomarker GDF-15 provides prognostic information in ARDS that is additive to that provided by the APACHE III score. Patients with high levels of growth-differentiation factor 15 (GDF-15) had a higher mortality and more complicated hospital course. Biomarkers such as GDF-15 may help us to identify patients at higher risk who may eventually benefit from more personalized and targeted therapies.
authors.forename: Tibor
authors.initials: T
authors.lastname: Kempf
authors.forename: Kai C
authors.initials: KC
authors.lastname: Wollert
mesh_terms: D005260:Female; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D006801:Humans; D008297:Male; D012128:Respiratory Distress Syndrome / Q000097:blood*
chemical_list: D055436:Growth Differentiation Factor 15
references.citation: Am J Respir Crit Care Med. 2008 Sep 1;178(5):534-41
references.pmid: 18565955
references.citation: Am J Respir Crit Care Med. 2008 May 1;177(9):1018-25
references.pmid: 18263797
references.citation: Circulation. 2007 Feb 27;115(8):962-71
references.pmid: 17283261
references.citation: Am J Epidemiol. 2012 Sep 15;176(6):473-81
references.pmid: 22875755
references.citation: Circ Cardiovasc Genet. 2009 Jun;2(3):286-92
references.pmid: 20031597
references.citation: Circulation. 2010 Oct 5;122(14):1387-95
references.pmid: 20855664
references.citation: Cerebrovasc Dis. 2011;32(1):72-8
references.pmid: 21613788
references.citation: Crit Care. 2013 May 24;17(3):R92
references.pmid: 23706007
references.citation: Eur J Heart Fail. 2012 Nov;14(11):1249-56
references.pmid: 22843564