title: Resistance by allostery: a novel perspective for eg5-targeted drug design.
abstract: Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon "resistance by allostery", which could have far-reaching consequences from a rational drug design perspective.
authors.affiliation: Center for Neuro-Medicine, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.
authors.forename: Ambily Nath Indu
authors.initials: AN
authors.lastname: Viswanath
authors.forename: Ae Nim
authors.initials: AN
authors.lastname: Pae
mesh_terms: D000494:Allosteric Regulation; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D016547:Kinesins / Q000737:chemistry / Q000187:drug effects*; D008958:Models, Molecular
chemical_list: D001549:Benzamides; D002867:Chromones; C470243:KIF11 protein, human; C557279:SB 743921; D016547:Kinesins