title: Rheumatoid arthritis. Triple therapy or etanercept after methotrexate failure in RA?
abstract: Since the 1990s, patients with rheumatoid arthritis have been treated with at least one DMARD. Methotrexate, which is usually the first-line treatment, elicits good or even excellent clinical results in 20–30% of patients—but in most patients it does not. Thus, an important question is what to do after methotrexate failure.
authors.affiliation: Unit for Clinical Therapy Research, Inflammatory Diseases, The Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. ronald.van.vollenhoven@ki.se
authors.forename: Ronald F
authors.initials: RF
authors.lastname: van Vollenhoven
authors.forename: Katerina
authors.initials: K
authors.lastname: Chatzidionysiou
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D000068800:Etanercept; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use*; D007074:Immunoglobulin G / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use*; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D012460:Sulfasalazine / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D012460:Sulfasalazine; D006886:Hydroxychloroquine; D000068800:Etanercept; D008727:Methotrexate
references.citation: Lancet. 2009 Aug 8;374(9688):459-66
references.pmid: 19665644
references.citation: Ann Intern Med. 2007 Mar 20;146(6):406-15
references.pmid: 17371885
references.citation: Ann Rheum Dis. 2009 Apr;68(4):456-9
references.pmid: 19286904
references.citation: Lancet. 2012 May 5;379(9827):1712-20
references.pmid: 22464340
references.citation: Arthritis Rheum. 2012 Sep;64(9):2824-35
references.pmid: 22508468
references.citation: Arthritis Rheum. 2002 May;46(5):1164-70
references.pmid: 12115219
references.citation: Lancet. 1999 May 8;353(9164):1568-73
references.pmid: 10334255
references.citation: N Engl J Med. 1996 May 16;334(20):1287-91
references.pmid: 8609945
references.citation: Ann Rheum Dis. 2010 Jun;69(6):964-75
references.pmid: 20444750
references.citation: N Engl J Med. 2013 Jul 25;369(4):307-18
references.pmid: 23755969