title: Effect of prostaglandin E2 on myometrial electrical activity in women undergoing induction of labor.
abstract: OBJECTIVE
  To investigate the effect of prostaglandin E2 (PGE2) on electrical uterine activity using a novel uterine muscle electromyography device in patients undergoing induction of labor.
  
  
  METHODS
  Electrical uterine myography (EUM) was prospectively measured using a noninvasive nine channels recorder in 31 women undergoing induction of labor with vaginal PGE2 tablets. Women were monitored before and up to 12 hours after vaginal PGE2 application. EUM index was defined as mean electrical activity of the uterine muscle over a period of 10 minutes measured in units of microjoule (µJ, µWs).
  
  
  RESULTS
  The EUM index was not increased significantly during the first 2 hours following PGE2 application (overall increase of 5.3 ± 60.1%, p = 0.7). Peak EUM activity was observed during 2 to 8 hours following PGE2 application, which represented a statistically significant increase compared with the EUM index before PGE2 application (3.3 ± 0.5 µJ vs. 2.5 ± 0.95 µJ, p = 0.01), and with the EUM index 0 to 2 hours following PGE2 application (3.3 ± 0.5 µJ vs. 2.3 ± 0.9 µJ, p = 0.004).
  
  
  CONCLUSIONS
  The data suggests that in women undergoing labor induction with PGE2, uterine activity peaks 2 to 8 hours following PGE2 application. This information may provide more insight into the mechanism of PGE2 action.
authors.affiliation: Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Aviram
authors.affiliation: Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Nir
authors.initials: N
authors.lastname: Melamed
authors.affiliation: Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Hadar
authors.affiliation: Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Oded
authors.initials: O
authors.lastname: Raban
authors.affiliation: Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Liran
authors.initials: L
authors.lastname: Hiersch
authors.affiliation: Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Yogev
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D015232:Dinoprostone; D004576:Electromyography / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D009215:Myometrium / Q000187:drug effects*; D010120:Oxytocics; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D010120:Oxytocics; D015232:Dinoprostone