title: On the role of tyrosine phosphatases as negative regulators of STAT signaling in breast cancers: new findings and future perspectives.
abstract: The increasing importance of signal transducer and activator of transcription 3 (STAT3) expression in human cancers has led several laboratories to examine in detail the expression of one of its major negative regulators in oncogenesis--the T-cell protein tyrosine phosphatase, nonreceptor type 2 (PTPN2). A recent paper by Shields and colleagues points to the associate depletion of PTPN2 in STAT3-positive breast cancers. We examine these findings and reflect on the mechanism of action of PTPN2 and the consequences of its modulation for STAT3 downstream signaling.
authors.forename: Michel L
authors.initials: ML
authors.lastname: Tremblay
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D001943:Breast Neoplasms / Q000378:metabolism; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2 / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000378:metabolism
chemical_list: D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2; D019061:src-Family Kinases; D050796:STAT3 Transcription Factor
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