title: The calcium-sensing receptor directly regulates proximal tubular functions.
abstract: Capasso et al. show a role of the calcium-sensing receptor (CaSR) in enhancing proximal tubular fluid absorption and urinary acidification by stimulation of luminal Na(+)/H(+) exchanger (NHE) activity. NHE3 is required for sodium and fluid absorption, and its activity is coupled to passive reabsorption of a major fraction of calcium through the paracellular route. These data shed new light on the regulation of the kidney by the CaSR and whether it directly affects proximal tubular functions.
authors.affiliation: Institute of Physiology, University of Zurich, Zurich, Switzerland. Wagnerca@access.uzh.ch
authors.forename: Carsten A
authors.initials: CA
authors.lastname: Wagner
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008297:Male; D044169:Receptors, Calcium-Sensing / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: C577923:CASR protein, mouse; D044169:Receptors, Calcium-Sensing; D043562:Receptors, G-Protein-Coupled; C473605:extracellular calcium cation-sensing receptor, rat; D002118:Calcium