title: Prevention of cytomegalovirus following solid organ transplantation: a literature review.
abstract: CMV is the most common opportunistic infection affecting SOT recipients. Although current strategies to prevent both CMV infection and disease have been effective, CMV related complications continue to occur, particularly late-onset CMV disease. This literature review article examines the benefits and disadvantages of different prevention modalities, and presents emerging strategies to better prevent CMV in organ transplant recipients.
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. shanna.kowalsky@mssm.edu
authors.forename: Shanna
authors.initials: S
authors.lastname: Kowalsky
authors.forename: Ronen
authors.initials: R
authors.lastname: Arnon
authors.forename: Roberto
authors.initials: R
authors.lastname: Posada
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000517:prevention & control*; D022482:Cytomegalovirus Vaccines / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016377:Organ Transplantation / Q000009:adverse effects / Q000379:methods*; D011183:Postoperative Complications / Q000821:virology*; D012306:Risk; D013601:T-Lymphocytes / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents; D016207:Cytokines; D022482:Cytomegalovirus Vaccines; D004279:DNA, Viral; D007166:Immunosuppressive Agents; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D015774:Ganciclovir
keywords: CMV; pediatric; prevention; solid organ transplantation; transplantation