title: Dedifferentiated liposarcoma of the spermatic cord with a hemangioendothelioma-like component: a case report and review of the literature.
abstract: Atypical lipomatous tumor or well-differentiated liposarcoma/dedifferentiated liposarcoma (DDLPS) is the most frequent subtype of malignant adipocytic tumor. This tumor typically presents in late adult life, most commonly in the retroperitoneum, extremities, or spermatic cord. It has been reported that the dedifferentiated component consists mainly of high-grade sarcoma, including undifferentiated pleomorphic sarcoma, fibrosarcoma, and myxofibrosarcoma, and it has been recently reported that the dedifferentiated component can be also made up of a low-grade sarcomatous component. Therefore, the dedifferentiated areas exhibit a wide morphological spectrum that commonly includes fibroblastic/myofibroblastic and fibrohistiocytic tumors but very rarely includes vascular tumors. We present here the first reported case of DDLPS with a hemangioendothelioma-like component in the spermatic cord.
authors.affiliation: Department of Innovative Applied Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Division of Diagnostic pathology, Kyushu University Hospital, Fukuoka 812-8582, Japan. Electronic address: okap@surg2.med.kyushu-u.ac.jp.
authors.forename: Shinji
authors.initials: S
authors.lastname: Okano
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Shinji
authors.initials: S
authors.lastname: Kono
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujii
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005834:Genital Neoplasms, Male / Q000378:metabolism / Q000473:pathology*; D006390:Hemangioendothelioma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008080:Liposarcoma / Q000378:metabolism / Q000473:pathology*; D008297:Male; D013085:Spermatic Cord / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: CDK4; D2-40; Dedifferentiated liposarcoma; Hemangioendothelioma; MDM2