title: Hormonal and histological changes in the ovaries with high-doses of methylprednisolone administration for acute spinal cord injury: an experimental study.
abstract: This study was conducted to investigate the hormonal and histological changes in the ovaries with high doses of methylprednisolone administration for acute spinal cord injury (SCI). Group I (trauma group, eight rats) were subjected to laminectomy and SCI but received no treatment. Group II (steroid group, eight rats) were subjected to SCI and received methylprednisolone (30 mg/kg, intraperitoneally). Group III (control group, six rats) underwent a sham operation without trauma and treatment. Malondialdehyde (MDA) levels were significantly decreased in Group II (p < 0.05). The scores of histopathological damage of the ovaries in the three groups were found to be statistically comparable (p > 0.05). Serum anti-Müllerian hormone (AMH) levels in the steroid group was significantly lower compared with the control group (p < 0.05). High-dose methylprednisolone administration may effect ovarian reserve with reversible ovarian damage and can resolve lipid peroxidation in rats with spinal cord injury.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey. drmaosmanaga@gmail.com
authors.forename: M A
authors.initials: MA
authors.lastname: Osmanağaoğlu
authors.forename: H
authors.initials: H
authors.lastname: Usul
authors.forename: E
authors.initials: E
authors.lastname: Yuluğ
authors.forename: M
authors.initials: M
authors.lastname: Kesim
authors.forename: S C
authors.initials: SC
authors.lastname: Karahan
mesh_terms: D000818:Animals; D005260:Female; D008775:Methylprednisolone / Q000009:adverse effects*; D018696:Neuroprotective Agents / Q000009:adverse effects*; D010053:Ovary / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000188:drug therapy*
chemical_list: D018696:Neuroprotective Agents; D008775:Methylprednisolone