title: Nerve physiology: mechanisms of injury and recovery.
abstract: Peripheral nerve injuries are common conditions, with broad-ranging groups of symptoms depending on the severity and nerves involved. Although much knowledge exists on the mechanisms of injury and regeneration, reliable treatments that ensure full functional recovery are scarce. This review aims to summarize various ways these injuries are classified in light of decades of research on peripheral nerve injury and regeneration.
authors.affiliation: School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA.
authors.forename: Ron M G
authors.initials: RM
authors.lastname: Menorca
authors.forename: Theron S
authors.initials: TS
authors.lastname: Fussell
authors.forename: John C
authors.initials: JC
authors.lastname: Elfar
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D008264:Macrophages / Q000502:physiology; D023421:Models, Animal; D008954:Models, Biological; D009408:Nerve Compression Syndromes / Q000209:etiology / Q000503:physiopathology; D009412:Nerve Fibers / Q000502:physiology; D009414:Nerve Growth Factors / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D059348:Peripheral Nerve Injuries / Q000145:classification / Q000209:etiology / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000033:anatomy & histology / Q000502:physiology*; D012583:Schwann Cells / Q000502:physiology; D014855:Wallerian Degeneration / Q000503:physiopathology
chemical_list: D009414:Nerve Growth Factors
keywords: Nerve injury; Nerve physiology; Nerve recovery; Peripheral nerve injuries
references.citation: J Hand Surg Am. 2010 Apr;35(4):668-77
references.pmid: 20223605
references.citation: Lancet. 1973 Aug 18;2(7825):359-62
references.pmid: 4124532
references.citation: J Neurosci Res. 2007 Mar;85(4):766-77
references.pmid: 17266098
references.citation: Proc Natl Acad Sci U S A. 1988 Mar;85(5):1701-5
references.pmid: 3422757
references.citation: J Comp Neurol. 2003 Jun 23;461(2):174-86
references.pmid: 12724836
references.citation: J Am Acad Orthop Surg. 2011;19 Suppl 1:S28-34
references.pmid: 21304044
references.citation: Acta Neuropathol. 1997 Mar;93(3):252-9
references.pmid: 9083556
references.citation: J Neurosci. 1991 Aug;11(8):2528-44
references.pmid: 1831228
references.citation: J Cell Biol. 1990 Apr;110(4):1353-60
references.pmid: 2157720
references.citation: J Hand Surg Am. 2013 Apr;38(4):799-801; quiz 801
references.pmid: 23466128
references.citation: Cell Motil Cytoskeleton. 1999;42(4):331-43
references.pmid: 10223638
references.citation: Ann Plast Surg. 1988 Feb;20(2):117-9
references.pmid: 3355055
references.citation: Proc Natl Acad Sci U S A. 1976 Jul;73(7):2424-8
references.pmid: 1065897
references.citation: J Neurosci. 1999 Oct 15;19(20):8945-53
references.pmid: 10516313
references.citation: J Neurosci Res. 1995 Jul 1;41(4):501-9
references.pmid: 7473881
references.citation: Brain Pathol. 1997 Apr;7(2):741-52
references.pmid: 9161725
references.citation: J Neurosci Res. 1995 Jan 1;40(1):99-107
references.pmid: 7714930
references.citation: J Orthop Res. 2005 Jan;23(1):218-23
references.pmid: 15607896
references.citation: J Neurosci. 1998 Nov 1;18(21):8674-81
references.pmid: 9786974
references.citation: Muscle Nerve. 2006 Apr;33(4):445-61
references.pmid: 16228970
references.citation: J Cell Biol. 2008 May 19;181(4):625-37
references.pmid: 18490512
references.citation: J Neurosci Methods. 2003 Jul 15;127(1):43-7
references.pmid: 12865147
references.citation: Clin Neurophysiol. 2008 Sep;119(9):1951-65
references.pmid: 18482862
references.citation: Brain Res. 1985 Aug 19;341(1):16-25
references.pmid: 3929995
references.citation: Nat Neurosci. 2013 Jan;16(1):48-54
references.pmid: 23222914
references.citation: Orthopedics. 2009 Oct;32(10):758
references.pmid: 19835336
references.citation: Neuroscience. 1990;35(1):157-65
references.pmid: 2359492
references.citation: Mol Neurobiol. 1997 Feb-Apr;14(1-2):67-116
references.pmid: 9170101
references.citation: J Cell Biol. 1989 Feb;108(2):647-51
references.pmid: 2918028
references.citation: Diabetes Care. 2004 Jul;27(7):1783-8
references.pmid: 15220266
references.citation: Brain. 1951 Dec;74(4):491-516
references.pmid: 14895767
references.citation: Prog Neurobiol. 2007 Jul;82(4):163-201
references.pmid: 17643733
references.citation: Int Rev Neurobiol. 2009;87:1-7
references.pmid: 19682630
references.citation: J Anat. 1997 Jan;190 ( Pt 1):57-71
references.pmid: 9034882
references.citation: J Hand Surg Am. 1987 Jul;12(4):552-9
references.pmid: 3611653
references.citation: J Exp Biol. 1946 May;22:203-12
references.pmid: 20988224
references.citation: J Neurotrauma. 2009 Dec;26(12):2245-56
references.pmid: 19645529
references.citation: J Bone Joint Surg Am. 2008 Aug;90(8):1644-53
references.pmid: 18676893
references.citation: J Neurosci. 1996 Sep 15;16(18):5698-703
references.pmid: 8795625
references.citation: Microsurgery. 1998;18(7):397-405
references.pmid: 9880154
references.citation: Ann Plast Surg. 1987 Nov;19(5):430-5
references.pmid: 3688790
references.citation: J Cell Biol. 1993 Oct;123(2):455-65
references.pmid: 8408225
references.citation: J Cell Sci. 2009 Oct 15;122(Pt 20):3595-604
references.pmid: 19812305
references.citation: Brain Res. 1977 Oct 7;134(2):367-71
references.pmid: 19130
references.citation: Nature. 1994 Oct 27;371(6500):796-9
references.pmid: 7935840
references.citation: Histol Histopathol. 2008 Feb;23(2):157-66
references.pmid: 17999372
references.citation: Science. 1995 May 19;268(5213):971-3
references.pmid: 7754391
references.citation: Ann Plast Surg. 1991 Mar;26(3):259-64
references.pmid: 2029136
references.citation: J Comp Neurol. 2009 Jul 20;515(3):295-312
references.pmid: 19425080
references.citation: J Neurol. 2005 Apr;252(4):448-52
references.pmid: 15726259
references.citation: Ann Anat. 2011 Jul;193(4):321-33
references.pmid: 21640570
references.citation: Scand J Plast Reconstr Surg Hand Surg. 2003;37(1):14-7
references.pmid: 12625389
references.citation: J Neurol Sci. 1984 May;64(2):193-8
references.pmid: 6747666
references.citation: J Physiol. 1974 Feb;236(3):517-38
references.pmid: 4822574
references.citation: Cell Mol Biol (Noisy-le-grand). 2005 Sep 05;51(3):255-67
references.pmid: 16191393
references.citation: J Hand Surg Br. 1990 Feb;15(1):5-10
references.pmid: 2407794
references.citation: Cell. 2003 Jun 27;113(7):867-79
references.pmid: 12837245
references.citation: Neurosurg Focus. 2009 Feb;26(2):E7
references.pmid: 19435447
references.citation: Annu Rev Neurosci. 1996;19:341-77
references.pmid: 8833447
references.citation: J Neurochem. 2008 May;105(4):1244-52
references.pmid: 18194437
references.citation: J Neurotrauma. 2006 Feb;23(2):216-26
references.pmid: 16503805
references.citation: Neuron. 1992 May;8(5):865-8
references.pmid: 1316763
references.citation: Exp Neurol. 2006 Aug;200(2):418-29
references.pmid: 16764860
references.citation: Neuroscience. 1989;29(3):659-66
references.pmid: 2500618
references.citation: Brain Res. 1972 Oct 13;45(1):49-65
references.pmid: 4561629
references.citation: J Neurosci Res. 1991 Jul;29(3):396-400
references.pmid: 1833560
references.citation: J Physiol. 1970 Apr;207(2):507-28
references.pmid: 5499034
references.citation: Cell. 1996 May 17;85(4):525-35
references.pmid: 8653788
references.citation: Ann N Y Acad Sci. 1999 Sep 14;883:215-33
references.pmid: 10586247
references.citation: J Reconstr Microsurg. 2005 Apr;21(3):179-86
references.pmid: 15880297
references.citation: Glia. 2008 Nov 1;56(14):1491-1497
references.pmid: 18803318
references.citation: J Neuropathol Exp Neurol. 1973 Apr;32(2):256-70
references.pmid: 4576231
references.citation: Int Rev Neurobiol. 2009;87:27-46
references.pmid: 19682632
references.citation: J Mol Neurosci. 2003;21(1):65-72
references.pmid: 14500997
references.citation: Nihon Seikeigeka Gakkai Zasshi. 1983 Nov;57(11):1773-86
references.pmid: 6676393
references.citation: Mol Cell Neurosci. 1998 May;11(1-2):1-8
references.pmid: 9608528
references.citation: J Neurosci Res. 1998 Jul 15;53(2):260-7
references.pmid: 9671983
references.citation: J Neurosci Methods. 2008 Mar 30;169(1):119-27
references.pmid: 18201767
references.citation: J Orthop Sci. 2003;8(1):69-74
references.pmid: 12560889
references.citation: J Neurocytol. 1994 Nov;23(11):657-67
references.pmid: 7861182
references.citation: Neurosurg Focus. 2004 May 15;16(5):E1
references.pmid: 15174821
references.citation: J Neurosci. 1994 May;14(5 Pt 2):3231-45
references.pmid: 8182468
references.citation: J Neurocytol. 1989 Oct;18(5):671-83
references.pmid: 2614485
references.citation: Neurosurgery. 2007 Apr;60(4):723-32; discussion 732-3
references.pmid: 17415210
references.citation: Muscle Nerve. 2012 Feb;45(2):231-41
references.pmid: 22246880
references.citation: Eur J Neurosci. 2009 Aug;30(3):366-75
references.pmid: 19656172
references.citation: J Neurocytol. 1978 Oct;7(5):555-69
references.pmid: 722316
references.citation: Scand J Plast Reconstr Surg. 1977;11(3):179-87
references.pmid: 609900
references.citation: J Neurosci. 1998 Aug 1;18(15):5891-900
references.pmid: 9671676
references.citation: Microsurgery. 2004;24(3):182-7
references.pmid: 15160375