title: Caveolin-1 and migration of bone-marrow derived cells in the mouse eye.
abstract: Bone marrow derived cells (BMDCs) can be found in almost every tissue showing a distinct turnover and density. Since caveolin-1 regulates junction-associated proteins in endothelial and epithelial cells, its role for BMDC was investigated in the eyes of caveolin-1 knock-out mice transplanted with GFP-marked BMDC. Distribution and turnover of BMDC in connective tissues (cornea, iris, ciliary body and choroid) was not altered. The absence of caveolin-1, however, caused a significant decrease of BMDC turnover in cornea epithelium, ciliary epithelium, and in the retina. This finding emphasizes an important, hitherto unknown role of caveolin-1 in neuronal and epithelial tissues.
authors.affiliation: Department of Anatomy, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany. Electronic address: Albrecht.May@mailbox.tu-dresden.de.
authors.forename: Christian-Albrecht
authors.initials: CA
authors.lastname: May
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D051242:Caveolin 1 / Q000235:genetics / Q000378:metabolism*; D002465:Cell Movement; D003315:Cornea / Q000166:cytology / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D005123:Eye / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D012160:Retina / Q000166:cytology / Q000378:metabolism
chemical_list: D051242:Caveolin 1
keywords: Caveolin; Leucocytes; Mouse; Turnover