title: RIP3: a molecular switch for necrosis and inflammation.
abstract: The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of programmed necrosis/necroptosis, an inflammatory form of cell death with important functions in pathogen-induced and sterile inflammation. RIP3 activation is tightly regulated by phosphorylation, ubiquitination, and caspase-mediated cleavage. These post-translational modifications coordinately regulate the assembly of a macromolecular signaling complex termed the necrosome. Recently, several reports indicate that RIP3 can promote inflammation independent of its pronecrotic activity. Here, we review our current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases.
authors.affiliation: Department of Pathology, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
authors.forename: Kenta
authors.initials: K
authors.lastname: Moriwaki
authors.forename: Francis Ka-Ming
authors.initials: FK
authors.lastname: Chan
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D009336:Necrosis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D011499:Protein Processing, Post-Translational; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D053422:Receptor-Interacting Protein Serine-Threonine Kinases
keywords: FADD; MLKL; PGAM5; RIP1; caspase 8; inflammation
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