title: Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality.
abstract: Highly atroposelective Meyers' lactamization promoted by pivalic acid under microwave irradiation is reported which allows the construction of nonracemic substituted-dibenzo(di)azepine derivatives through a center to axial chirality transfer principle, controlling the otherwise configurationally labile biaryl axis. This approach provides a straightforward entry to enantioenriched analogues of biorelevant architectures.
authors.affiliation: Normandie Univ, COBRA, UMR 6014 et FR 3038, Univ Rouen, INSA Rouen, CNRS, IRCOF, 1 rue Tesnière, 76821 Mont Saint Aignan Cedex, France.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Postikova
authors.forename: Mohamad
authors.initials: M
authors.lastname: Sabbah
authors.forename: Daniel
authors.initials: D
authors.lastname: Wightman
authors.forename: Ich Tuan
authors.initials: IT
authors.lastname: Nguyen
authors.forename: Morgane
authors.initials: M
authors.lastname: Sanselme
authors.forename: Thierry
authors.initials: T
authors.lastname: Besson
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Brière
authors.forename: Sylvain
authors.initials: S
authors.lastname: Oudeyer
authors.forename: Vincent
authors.initials: V
authors.lastname: Levacher
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D001381:Azepines