title: Biocompatibility studies of polyacrylonitrile membranes modified with carboxylated polyetherimide.
abstract: Poly (ether-imide) (PEI) was carboxylated and used as the hydrophilic modification agent for the preparation of polyacrylonitrile (PAN) membranes. Membranes were prepared with different blend compositions of PAN and CPEI by diffusion induced precipitation. The modified membranes were characterized by thermo gravimetric analysis (TGA), mechanical analysis, scanning electron microscopy (SEM) and contact angle measurement to understand the influence of CPEI on the properties of the membranes. The biocompatibility studies exhibited reduced plasma protein adsorption, platelet adhesion and thrombus formation on the modified membrane surface. The complete blood count (CBC) results of CPEI incorporated membranes showed stable CBC values and significant decrease in the complement activation were also observed. In addition to good cytocompatibility, monocytes cultured on these modified membranes exhibited improved functional profiles in 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. Thus it could be concluded that PAN/CPEI membranes with excellent biocompatibility can be useful for hemodialysis.
authors.affiliation: Membrane Laboratory, Department of Chemical Engineering, Anna University, Chennai, 600025, India.
authors.forename: S
authors.initials: S
authors.lastname: Senthilkumar
authors.forename: S
authors.initials: S
authors.lastname: Rajesh
authors.forename: A
authors.initials: A
authors.lastname: Jayalakshmi
authors.forename: D
authors.initials: D
authors.lastname: Mohan
mesh_terms: D000180:Acrylic Resins / Q000494:pharmacology*; D000327:Adsorption; D000328:Adult; D017209:Apoptosis / Q000187:drug effects; D001672:Biocompatible Materials / Q000494:pharmacology*; D057219:Biofouling / Q000517:prevention & control; D001772:Blood Cell Count; D001798:Blood Proteins / Q000378:metabolism; D002245:Carbon Dioxide / Q000737:chemistry*; D003167:Complement Activation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D055595:Mechanical Phenomena; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness / Q000187:drug effects; D011108:Polymers / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013194:Staining and Labeling; D013696:Temperature; D013818:Thermogravimetry; D013927:Thrombosis / Q000378:metabolism
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D001798:Blood Proteins; D008567:Membranes, Artificial; D011108:Polymers; C433673:polyetherimide; D002245:Carbon Dioxide; C010504:polyacrylonitrile
keywords: Blood compatibility; Carboxylation; Cytocompatibility; Polyetherimide; Protein adsorption