title: Well-balanced high-order solver for blood flow in networks of vessels with variable properties.
abstract: We present a well-balanced, high-order non-linear numerical scheme for solving a hyperbolic system that models one-dimensional flow in blood vessels with variable mechanical and geometrical properties along their length. Using a suitable set of test problems with exact solution, we rigorously assess the performance of the scheme. In particular, we assess the well-balanced property and the effective order of accuracy through an empirical convergence rate study. Schemes of up to fifth order of accuracy in both space and time are implemented and assessed. The numerical methodology is then extended to realistic networks of elastic vessels and is validated against published state-of-the-art numerical solutions and experimental measurements. It is envisaged that the present scheme will constitute the building block for a closed, global model for the human circulation system involving arteries, veins, capillaries and cerebrospinal fluid.
authors.affiliation: Laboratory of Applied Mathematics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Via Mesiano 77, I-38100 Trento, Italy.
authors.forename: Lucas O
authors.initials: LO
authors.lastname: Müller
authors.forename: Eleuterio F
authors.initials: EF
authors.lastname: Toro
mesh_terms: D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D012039:Regional Blood Flow / Q000502:physiology*
keywords: ADER framework; DOT Riemann solver; blood flow; high order; path-conservative approach; vessels with variable properties; well-balanced scheme