title: Effect of carrageenans of different chemical structures in biointerfaces: a Langmuir film study.
abstract: Carrageenans have unique properties in the pharmaceutical and food industries that involve interactions with lipid interfaces, which may be accessed if surface chemistry techniques are employed. The interaction between three different types of carrageenans with dipalmitoylphosphatidylcholine (DPPC) was investigated using Langmuir monolayers as biointerface models. With a combination of data on Surface Pressure-Area Isotherms and Polarization Modulation Infrared Reflection-Absorption Spectroscopy (PM-IRRAS), the effect of different fractions on DPPC monolayers was compared by considering the chemical and structural differences as well as the anticoagulant activity of each fraction. Thus, a model is proposed in which carrageenans can encompass interactions that are maximized due to geometrical adaptations on behalf of the interactions between polysaccharide sulfate groups and lipid polar heads.
authors.affiliation: Institute of Environmental, Chemical and Phamaceutical Sciences, Federal University of São Paulo, Diadema, SP, Brazil.
authors.forename: Ricardo F
authors.initials: RF
authors.lastname: Lopez
authors.affiliation: São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil.
authors.forename: Thatyane M
authors.initials: TM
authors.lastname: Nobre
authors.affiliation: Departament of Biochemistry, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Camila de Melo
authors.initials: Cde M
authors.lastname: Accardo
authors.affiliation: Institute of Environmental, Chemical and Phamaceutical Sciences, Federal University of São Paulo, Diadema, SP, Brazil; Departament of Biochemistry, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Pernambuco Filho
authors.affiliation: Departament of Biochemistry, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Helena B
authors.initials: HB
authors.lastname: Nader
authors.affiliation: Institute of Environmental, Chemical and Phamaceutical Sciences, Federal University of São Paulo, Diadema, SP, Brazil; Departament of Biochemistry, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Carla C
authors.initials: CC
authors.lastname: Lopes
authors.affiliation: Institute of Environmental, Chemical and Phamaceutical Sciences, Federal University of São Paulo, Diadema, SP, Brazil. Electronic address: lcaseli@unifesp.br.
authors.forename: Luciano
authors.initials: L
authors.lastname: Caseli
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D000925:Anticoagulants / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry*; D002351:Carrageenan / Q000737:chemistry / Q000494:pharmacology*; D019245:Compressive Strength / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D013696:Temperature
chemical_list: D000925:Anticoagulants; D001672:Biocompatible Materials; D015060:1,2-Dipalmitoylphosphatidylcholine; D002351:Carrageenan; D006493:Heparin
keywords: Anti-coagulant; Biointerfaces; Carrageenans; Langmuir monolayers