title: Age and sex effects on the single- and multiple-dose safety and pharmacokinetics of the new rennin inhibitor ACT-178882.
authors.affiliation: Janssen Biologics BV, Leiden, Netherlands.
authors.forename: Dick E
authors.initials: DE
authors.lastname: de Vries
authors.forename: Hiddo J
authors.initials: HJ
authors.lastname: Lambers Heerspink
mesh_terms: D000367:Age Factors; D003521:Cyclopropanes / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D011725:Pyridines / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D012737:Sex Factors; D000092502:Renin Inhibitors
chemical_list: D003521:Cyclopropanes; D011725:Pyridines; D000092502:Renin Inhibitors; C571787:MK-1597