title: PTPN22 in autoimmunity: different cell and different way.
abstract: The tyrosine phosphatase PTPN22 regulates T cell receptor signaling. In this issue of Immunity, Wang et al. (2013) show that in myeloid cells PTPN22 potentiates TLR-induced type I interferon production and that autoimmunity-associated allele PTPN22W encodes a reduced-function variant.
authors.affiliation: Arthritis and Tissue Degeneration Program and Genomics Center, Hospital for Special Surgery, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA. ivashkivl@hss.edu
authors.forename: Lionel B
authors.initials: LB
authors.lastname: Ivashkiv
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D006801:Humans; D007109:Immunity / Q000276:immunology*; D007370:Interferon Type I / Q000276:immunology*; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D007370:Interferon Type I; D051193:Toll-Like Receptors; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; C516766:Ptpn22 protein, mouse
references.citation: Arthritis Rheum. 2012 Oct;64(10):3119-28
references.pmid: 22614743
references.citation: Nat Rev Immunol. 2011 Jun 10;11(7):457-68
references.pmid: 21660053
references.citation: Immunity. 2013 Jul 25;39(1):111-22
references.pmid: 23871208
references.citation: J Biol Chem. 2010 Aug 20;285(34):26506-18
references.pmid: 20538612
references.citation: FEBS Lett. 2011 Dec 1;585(23):3689-98
references.pmid: 21515266
references.citation: Immunity. 2008 May;28(5):675-86
references.pmid: 18424188
references.citation: J Clin Invest. 2005 Mar;115(3):695-702
references.pmid: 15765149
references.citation: Genes Immun. 2012 Dec;13(8):641-52
references.pmid: 23076337
references.citation: J Immunol. 2007 Feb 15;178(4):2204-11
references.pmid: 17277125
references.citation: Arthritis Res Ther. 2010;12 Suppl 1:S1
references.pmid: 20392288