title: Normal gray and white matter volume after weight restoration in adolescents with anorexia nervosa.
abstract: OBJECTIVE
  The aim of this study was to determine whether treated, weight-stabilized adolescents with anorexia nervosa (AN) present brain volume differences in comparison with healthy controls.
  
  
  METHODS
  Thirty-five adolescents with weight-recovered AN and 17 healthy controls were assessed by means of psychopathology scales and magnetic resonance imaging. Axial three-dimensional T1-weighted images were obtained in a 1.5 Tesla scanner and analyzed using optimized voxel-based morphometry (VBM).
  
  
  RESULTS
  There were no significant differences between controls and weight-stabilized AN patients with regard to global volumes of either gray or white brain matter, or in the regional VBM study. Differences were not significant between patients with psychopharmacological treatment and without, between those with amenorrhea and without, as well as between patients with restrictive versus purgative AN.
  
  
  CONCLUSIONS
  The present findings reveal no global or regional gray or white matter abnormalities in this sample of adolescents following weight restoration.
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain; IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
authors.forename: Luisa
authors.initials: L
authors.lastname: Lázaro
authors.forename: Susana
authors.initials: S
authors.lastname: Andrés
authors.forename: Anna
authors.initials: A
authors.lastname: Calvo
authors.forename: Clàudia
authors.initials: C
authors.lastname: Cullell
authors.forename: Elena
authors.initials: E
authors.lastname: Moreno
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Plana
authors.forename: Carles
authors.initials: C
authors.lastname: Falcón
authors.forename: Núria
authors.initials: N
authors.lastname: Bargalló
authors.forename: Josefina
authors.initials: J
authors.lastname: Castro-Fornieles
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000473:pathology* / Q000523:psychology; D001835:Body Weight / Q000502:physiology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019964:Mood Disorders / Q000175:diagnosis; D012559:Schizophrenia / Q000175:diagnosis; D013030:Spain; D014888:Wechsler Scales
keywords: adolescents; anorexia nervosa; neuroimaging; statistical parametric mapping