title: Haloperidol for severe anorexia nervosa restricting type with delusional body image disturbance: a nine-case chart review.
abstract: Here we report on a case series chart review conducted on nine severe and treatment-resistant patients with anorexia nervosa, body mass index < 13 kg/m(2), and a delusional body image disturbance. Patients received low doses of haloperidol during hospitalization. Haloperidol was well tolerated. The delusional body image disturbance and the drive for thinness were subjectively perceived as less intense. BMI increased from the initial 12.2 ± 0.5 to 16.0 ± 1.5 kg/m(2). Mean pulse rate and blood pressure did not change significantly from admission to discharge (66 ± 11.6 bpm; 91/56 mmHg vs 77 ± 12.0 bpm; 102/66 mmHg). Mean of QTc, available from electrocardiograms performed during hospitalization, was 413 ± 38.5 ms (range 342-469 ms). Further investigations are warranted to elucidate clinical usefulness and safety of low doses of haloperidol for patients with treatment-resistant anorexia and delusional body image disturbance.
authors.affiliation: Department of Clinical and Experimental Medicine, Psychiatric Clinic, University of Pisa, 57 Roma Street, Pisa, 56100, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Mauri
authors.forename: Mario
authors.initials: M
authors.lastname: Miniati
authors.forename: Michela Giorgi
authors.initials: MG
authors.lastname: Mariani
authors.forename: Agnese
authors.initials: A
authors.lastname: Ciberti
authors.forename: Liliana
authors.initials: L
authors.lastname: Dell'Osso
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D057215:Body Dysmorphic Disorders / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D001828:Body Image / Q000523:psychology*; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol
references.citation: Int J Eat Disord. 2002 Sep;32(2):206-12
references.pmid: 12210663
references.citation: Int J Eat Disord. 2003 Mar;33(2):172-7
references.pmid: 12616583
references.citation: Int J Eat Disord. 2010 Nov 1;43(7):577-83
references.pmid: 19728374
references.citation: Int J Eat Disord. 2013 May;46(4):332-9
references.pmid: 23001863