title: Studies on the anti-diarrheal properties of leaf extract of Desmodium puchellum.
abstract: OBJECTIVE
  To evaluate the pharmacological activity against diarrhea of methanol and petroleum ether extract of Desmodium puchellum (Family: Fabaceae) leaves.
  
  
  METHODS
  The extract was evaluated for castor oil-induced diarrhea and enteropooling as well as intestinal motility in rats. Both of the extracts were given to the rats at 200 mg/kg orally. Loperamide was used as a standard drug for diarrhea.
  
  
  RESULTS
  The diarrheal severity was reduced significantly (P<0.05) by methanol and petroleum ether extracts by 31.95% and 28.33%, respectively, whereas 54.75% inhibition was found for standard drug loperamide at 5 mg/kg. The two extracts also significantly (P<0.05) reduced the intestinal volume in case of castor oil induced enteropooling.
  
  
  CONCLUSIONS
  It is concluded that both fractions contain some biologically active ingredients that are active for anti-diarrheal actions whereas methanol fraction has better potential.
authors.affiliation: Department of Pharmacy, International Islamic University Chittagong, Bangladesh.
authors.forename: Md Khalilur
authors.initials: MK
authors.lastname: Rahman
authors.forename: Soumitra
authors.initials: S
authors.lastname: Barua
authors.forename: Md Fokhrul
authors.initials: MF
authors.lastname: Islam
authors.forename: Md Rafikul
authors.initials: MR
authors.lastname: Islam
authors.forename: Mohammed Abu
authors.initials: MA
authors.lastname: Sayeed
authors.forename: Mst Shahnaj
authors.initials: MS
authors.lastname: Parvin
authors.forename: Md Ekramul
authors.initials: ME
authors.lastname: Islam
mesh_terms: D000473:Alkanes / Q000737:chemistry; D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D002368:Castor Oil / Q000009:adverse effects; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D008139:Loperamide / Q000494:pharmacology; D008297:Male; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats
chemical_list: D000473:Alkanes; D000930:Antidiarrheals; D005343:Fibrinolytic Agents; D010936:Plant Extracts; D008139:Loperamide; D002368:Castor Oil; C004544:naphtha; D000432:Methanol
keywords: Antidiarrhea; Desmodium puchellum; Loperamide; Thrombolysis
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