title: Chemical denervation of the renal artery with vincristine for the treatment of resistant arterial hypertension: first-in-man application.
abstract: Renal artery denervation has recently emerged as a novel therapy for patients with resistant hypertension. Clinical results from renal sympathetic denervation support the safety and efficacy of this method over a period of 18 months. However, several limitations have been reported. Previous studies have shown that chemical denervation by vincristine is safe and effective in an experimental model. We describe the first-in-man application of chemical denervation with vincristine in a 74-year-old male patient with resistant arterial hypertension.
authors.affiliation: First Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece. chstefan@med.uoa.gr
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Toutouzas
authors.forename: Charalambos
authors.initials: C
authors.lastname: Vlachopoulos
authors.forename: Costas
authors.initials: C
authors.lastname: Tsioufis
authors.forename: Andreas
authors.initials: A
authors.lastname: Synetos
authors.forename: Panagiota
authors.initials: P
authors.lastname: Pietri
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tousoulis
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Tsiamis
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001794:Blood Pressure; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D012077:Renal Artery / Q000294:innervation*; D013562:Sympathectomy / Q000379:methods*; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine