title: Lipid pools as photolabile "protecting groups": design of light-activatable bioagents.
abstract: Inactive in the membrane: Lipidated light-responsive constructs that sequester bioagents (R, see scheme) to the membranes of organelles and cells have been constructed. When membrane-bound, the bioagent is not susceptible to processing by its biological target. Photolysis releases the bioagent from its membrane anchor and thereby renders it biologically active.
authors.affiliation: Department of Biomedical Engineering, Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA).
authors.forename: Luong T
authors.initials: LT
authors.lastname: Nguyen
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Oien
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Allbritton
authors.forename: David S
authors.initials: DS
authors.lastname: Lawrence
mesh_terms: D005456:Fluorescent Dyes; D008027:Light; D008055:Lipids / Q000032:analysis; D018613:Microscopy, Confocal; D010782:Photolysis; D014357:Trypsin / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D008055:Lipids; D014357:Trypsin
keywords: biosensors; cell adhesion; fluorescent probes; phosphorylation; photolysis
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