title: Deconstructing sex differences in pain sensitivity.
authors.affiliation: Psychiatry Department, Harvard Medical School, Charlestown, MA, USA Massachusetts General Hospital, Charlestown, MA, USA Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada Department of Surgery and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
authors.forename: Javeria A
authors.initials: JA
authors.lastname: Hashmi
authors.forename: Karen D
authors.initials: KD
authors.lastname: Davis
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000503:physiopathology* / Q000523:psychology*; D017288:Pain Threshold / Q000502:physiology*; D012727:Sex Characteristics
references.citation: Abramov I, Gordon J, Feldman O, Chavarga A. Sex & vision I: spatio-temporal resolution. Biol Sex Differ 2012;3:20.
references.citation: Atherton K, Power C. Health inequalities with the National Statistics-Socioeconomic classification: disease risk factors and health in the 1958 British birth cohort. Eur J Publ Health 2007;17:486-491.
references.citation: Bartoshuk LM, Duffy VB, Miller IJ. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav 1994;56:1165-1171.
references.citation: Berkley KJ. Sex differences in pain. Behav Brain Sci 1997;20:371-380.
references.citation: Bernardes SF, Lima ML. Being less of a man or less of a woman: perceptions of chronic pain patients' gender identities. Eur J Pain 2010;14:194-199.
references.citation: Bingefors K, Isacson D. Epidemiology, co-morbidity, and impact on health-related quality of life of self-reported headache and musculoskeletal pain—a gender perspective. Eur J Pain 2004;8:435-450.
references.citation: Boles DB, Givens SM. Laterality and sex differences in tactile detection and two-point thresholds modified by body surface area and body fat ratio. Somatosens Mot Res 2011;28:102-109.
references.citation: Burgess DJ, van Ryn M, Crowley-Matoka M, Malat J. Understanding the provider contribution to race/ethnicity disparities in pain treatment: insights from dual process models of stereotyping. Pain Med 2006;7:119-134.
references.citation: Crombez G, Van Damme S, Eccleston C. Hypervigilance to pain: an experimental and clinical analysis. PAIN® 2005;116:4-7.
references.citation: Dalton P, Doolittle N, Breslin PA. Gender-specific induction of enhanced sensitivity to odors. Nat Neurosci 2002;5:199-200.
references.citation: Defrin R, Pope G, Davis KD. Interactions between spatial summation, 2-point discrimination and habituation of heat pain. Eur J Pain 2008;12:900-909.
references.citation: Feine JS, Bushnell MC, Miron D, Duncan GH. Sex differences in the perception of noxious heat stimuli. PAIN® 1991;44:255-262.
references.citation: Fillingim RB. Sex, gender, and pain: women and men really are different. Curr Rev Pain 2000;4:24-30.
references.citation: Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL 3rd. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 2009;10:447-485.
references.citation: Frenzel HBJ, Pinsker K, Wohlleben B, Tank J, Lechner SG, Schiska D, Jaijo T, Rüschendorf F, Saar K, Jordan J, Millán JM, Gross M, Lewin GR. A genetic basis for mechanosensory traits in humans. PLoS Biol 2012;10:e1001318.
references.citation: Genetta-Wadley A, Swirsky-Sacchetti T. Sex differences and handedness in hemispheric lateralization of tactile-spatial functions. Percept Mot Skills 1990;70:579-590.
references.citation: Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB, Gold MS, Holdcroft A, Lautenbacher S, Mayer EA, Mogil JS, Murphy AZ, Traub RJ. Consensus Working Group of the Sex G, Pain SIGotI. Studying sex and gender differences in pain and analgesia: a consensus report. PAIN® 2007;132:S26-S45.
references.citation: Greenspan JD, Slade GD, Bair E, Dubner R, Fillingim RB, Ohrbach R, Knott C, Mulkey F, Rothwell R, Maixner W. Pain sensitivity risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case control study. J Pain 2011;12:T61-T74.
references.citation: Hardy JD, Du Bois EF. Differences between men and women in their response to heat and cold. Proc Natl Acad Sci USA 1940;26:389-398.
references.citation: Hashmi JA, Davis KD. Effect of static and dynamic heat pain stimulus profiles on the temporal dynamics and interdependence of pain qualities, intensity, and affect. J Neurophysiol 2008;100:1706-1715.
references.citation: Hashmi JA, Davis KD. Women experience greater heat pain adaptation and habituation than men. PAIN® 2009;145:350-357.
references.citation: Hashmi JA, Davis KD. Effects of temperature on heat pain adaptation and habituation in men and women. PAIN® 2010;151:737-743.
references.citation: Hashmi JA, Davis KD. Noxious heat evokes stronger sharp and annoying sensations in women than men in hairy skin but not in glabrous skin. PAIN® 2010;151:323-329.
references.citation: Jameson KA, Highnote SM, Wasserman LM. Richer color experience in observers with multiple photopigment opsin genes. Psychon Bull Rev 2001;8:244-261.
references.citation: Jensen MT, Petersen KL. Gender differences in pain and secondary hyperalgesia after heat/capsaicin sensitization in healthy volunteers. J Pain 2006;7:211-217.
references.citation: Juni A, Cai M, Stankova M, Waxman AR, Arout C, Klein G, Dahan A, Hruby VJ, Mogil JS, Kest B. Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology 2010;112:181-188.
references.citation: Lee W, Reveille JD, Davis JC Jr, Learch TJ, Ward MM, Weisman MH. Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort. Ann Rheum Dis 2007;66:633-638.
references.citation: Leresche L. Defining gender disparities in pain management. Clin Orthop Relat Res 2011;469:1871-1877.
references.citation: Lillefjell M. Gender differences in psychosocial influence and rehabilitation outcomes for work-disabled individuals with chronic musculoskeletal pain. J Occup Rehabil 2006;16:659-674.
references.citation: Lundstrom JN, Hummel T. Sex-specific hemispheric differences in cortical activation to a bimodal odor. Behav Brain Res 2006;166:197-203.
references.citation: Mendell LM. Physiological properties of unmyelinated fiber projection to the spinal cord. Exp Neurol 1966;16:316-332.
references.citation: Mogil JS. Pain genetics: past, present and future. Trends Genet 2012;28:258-266.
references.citation: Mogil JS. Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon. Nat Rev Neurosci 2012;13:859-866.
references.citation: Mogil JS, Bailey AL. Sex and gender differences in pain and analgesia. Prog Brain Res 2010;186:141-157.
references.citation: Pickford RW. Frequencies of sex-linked red green colour vision defects. Nature 1947;160:335.
references.citation: Racine M, Tousignant-Laflamme Y, Kloda LA, Dion D, Dupuis G, Choiniere M. A systematic literature review of 10 years of research on sex/gender and experimental pain perception – part 1: are there really differences between women and men? PAIN® 2012;153:602-618.
references.citation: Racine M, Tousignant-Laflamme Y, Kloda LA, Dion D, Dupuis G, Choiniere M. A systematic literature review of 10 years of research on sex/gender and pain perception – part 2: do biopsychosocial factors alter pain sensitivity differently in women and men? PAIN® 2012;153:619-635.
references.citation: Richardson J, Holdcroft A. Gender differences and pain medication. Women Health (Lond Engl) 2009;5:79-90.
references.citation: Riley JL 3rd, Robinson ME, Wise EA, Myers CD, Fillingim RB. Sex differences in the perception of noxious experimental stimuli: a meta-analysis. PAIN® 1998;74:181-187.
references.citation: Rodriguez-Carmona M, Sharpe LT, Harlow JA, Barbur JL. Sex-related differences in chromatic sensitivity. Vis Neurosci 2008;25:433-440.
references.citation: Rolke R, Baron R, Maier C, Tolle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Botefur IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihofner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. PAIN® 2006;123:231-243.
references.citation: Sadato N, Ibanez V, Deiber MP, Hallett M. Gender difference in premotor activity during active tactile discrimination. Neuroimage 2000;11:532-540.
references.citation: Sarlani E, Grace EG, Reynolds MA, Greenspan JD. Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation. PAIN® 2004;109:115-123.
references.citation: Tubaldi F, Ansuini C, Tirindelli R, Castiello U. Odours grab his hand but not hers. Perception 2008;37:1886-1889.
references.citation: Wandner LD, Scipio CD, Hirsh AT, Torres CA, Robinson ME. The perception of pain in others: how gender, race, and age influence pain expectations. J Pain 2012;13:220-227.
references.citation: Wiesenfeld-Hallin Z. Sex differences in pain perception. Gender Med 2005;2:137-145.