title: [Corneal neovascularization: epidemiological, physiopathological, and clinical features].
abstract: Corneal neovascularization is defined as the presence of vessels within the normally avascular corneal stroma. This physiopathological process is the consequence of local hyper-expression of pro-angiogenic factors in response to tissue damage. These new vessels (neovessels), initially immature and poorly developed, predispose the cornea to lipid exudation, inflammation, and scarring. Additionally, the influx of vascular cells into the stroma induces a loss of the cornea's immune privilege, resulting in a higher rate of graft rejection. In this literature review, we touch on epidemiological, physiopathological, and clinical aspects of corneal neovascularization, as well as secondary complications.
authors.affiliation: Service d'ophtalmologie, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges cedex 1, France; Service d'ophtalmologie, clinique François-Chénieux, 18, rue du Général-Catroux, 87000 Limoges, France. Electronic address: yohanbenayoun@hotmail.fr.
authors.forename: Y
authors.initials: Y
authors.lastname: Benayoun
authors.forename: G
authors.initials: G
authors.lastname: Casse
authors.forename: R
authors.initials: R
authors.lastname: Forte
authors.forename: B
authors.initials: B
authors.lastname: Dallaudière
authors.forename: J-P
authors.initials: JP
authors.lastname: Adenis
authors.forename: P-Y
authors.initials: PY
authors.lastname: Robert
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D003315:Cornea / Q000098:blood supply / Q000378:metabolism; D016510:Corneal Neovascularization / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D004195:Disease Models, Animal; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology; D012307:Risk Factors; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D003094:Collagen
keywords: Angiogenesis; Angiogenèse; Corneal grafts; Corneal neovascularization; Greffes de cornée; Néovascularisation cornéenne