title: Teichoic acid biosynthesis as an antibiotic target.
abstract: The relentless spread of antibiotic-resistant pathogens makes it imperative to develop new chemotherapeutic strategies to overcome infection. The bacterial cell wall has served as a rich source for both validated and unexploited pathways that are essential for virulence and survival. Lipoteichoic acids (LTAs) and wall teichoic acids (WTAs) are cell wall polymers that play fundamental roles in Gram-positive bacterial physiology and pathogenesis, and both have been proposed as novel antibacterial targets. Here we describe recent progress toward the discovery of teichoic acid biosynthesis inhibitors and their potential as antibiotics to combat Staphylococcus aureus infections.
authors.affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States.
authors.forename: Lincoln W
authors.initials: LW
authors.lastname: Pasquina
authors.forename: John P
authors.initials: JP
authors.lastname: Santa Maria
authors.forename: Suzanne
authors.initials: S
authors.lastname: Walker
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D053898:Biosynthetic Pathways / Q000187:drug effects*; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism*; D013682:Teichoic Acids / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D013682:Teichoic Acids
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