title: Synthesis, characterization and cell viability test of six vanadyl complexes with acetylacetonate derivatives.
abstract: Vanadium compounds are known to display a number of therapeutic effects, namely insulin-mimetic and cardiovascular effects. Evidence of the antiproliferative and proapoptotic activity of a number of vanadyl complexes, together with their low toxicity, establishes these metal compounds as promising antitumoral therapeutic agents. In the present work, we describe the synthesis and full characterization of six new vanadyl complexes with acetylacetonate derivatives bearing asymmetric substitutions on the β-dicarbonyl moiety: the complexes were characterized in the solid state as well as in solution. Our results show that all complexes are in square pyramidal geometry; cis isomers in the equatorial plane are favored in the presence of strongly coordinating solvents. EPR evidence suggests that all complexes are in the bis-chelate form, although in two cases the mono-chelated complex seems to be present as well. Preliminary tests carried out on non-tumor and tumor cell lines show that these complexes are effective in suppressing cell viability and elicit a distinct response of tumor and non-tumor cells.
authors.affiliation: Dip.to di Chimica, University of Torino, Via Giuria 7, I-10125 Torino, Italy.
authors.forename: Speranza
authors.initials: S
authors.lastname: Sgarbossa
authors.forename: Eliano
authors.initials: E
authors.lastname: Diana
authors.forename: Domenica
authors.initials: D
authors.lastname: Marabello
authors.forename: Annamaria
authors.initials: A
authors.lastname: Deagostino
authors.forename: Silvano
authors.initials: S
authors.lastname: Cadamuro
authors.forename: Alessandro
authors.initials: A
authors.lastname: Barge
authors.forename: Enzo
authors.initials: E
authors.lastname: Laurenti
authors.forename: Margherita
authors.initials: M
authors.lastname: Gallicchio
authors.forename: Valentina
authors.initials: V
authors.lastname: Boscaro
authors.forename: Elena
authors.initials: E
authors.lastname: Ghibaudi
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004578:Electron Spin Resonance Spectroscopy; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D006885:Hydroxybutyrates / Q000737:chemistry*; D015394:Molecular Structure; D010422:Pentanones / Q000737:chemistry*; D050199:Podocytes / Q000166:cytology / Q000187:drug effects; D012996:Solutions / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman; D017968:Vanadium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D056831:Coordination Complexes; D006885:Hydroxybutyrates; D010422:Pentanones; D012996:Solutions; D012997:Solvents; D017968:Vanadium Compounds; C049529:acetyl acetonate; C034028:vanadyl sulfate
keywords: Acetylacetonate derivatives; Antitumoral metal complexes; EPR spectroscopy; Vanadyl compounds; Vibrational spectroscopy; X-ray crystallography