title: Associations between polymorphisms in the glucocorticoid-receptor gene and cardiovascular risk factors in a Chinese population.
abstract: BACKGROUND
  Glucocorticoid is an important regulator of energy homeostasis. Glucocorticoid receptor (GR) gene polymorphisms that contribute to variability in glucocorticoid sensitivity have been identified. We explored the associations of single-nucleotide polymorphisms (SNPs) of the GR gene with traditional cardiovascular risk factors in the Chinese Han population.
  
  
  METHODS
  We recruited 762 consecutive adults who underwent a regular physical examination at Beijing Xuanwu Hospital. Blood pressure, glucose, lipid levels (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein [LDL] cholesterol and triglycerides), body mass index (BMI), and waist-to-hip ratio were measured. Fourteen tag SNPs and 5 functional SNPs were selected and genotyped using the high-throughput Sequenom genotyping platform. Differences between genotypes/alleles for each SNP were adjusted for sex and age and tested using a general linear model procedure. Various models of inheritance, including additive, dominant, and recessive, were tested.
  
  
  RESULTS
  Among the 19 SNPs examined, 5 markers were associated with cardiovascular risk factors. The rs41423247 GG genotype and the rs7701443 AA genotype were associated with higher BMI and systolic blood pressure (P < 0.0004), and the rs17209251 GG genotype was associated with higher systolic blood pressure (P < 0.0004). Lower systolic blood pressure, total cholesterol, and LDL cholesterol were observed among rs10052957 A allele carriers (P < 0.0004), and lower plasma glucose and LDL-cholesterol concentrations were observed among rs2963156 TT carriers (P < 0.0004).
  
  
  CONCLUSIONS
  Polymorphism of the GR gene was associated with cardiovascular risk factors and may contribute to susceptibility to cardiovascular disease.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China.
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: Yan
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Wu
authors.forename: Shuang
authors.initials: S
authors.lastname: Shao
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.forename: You-Qin
authors.initials: YQ
authors.lastname: Liu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000235:genetics*; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D011965:Receptors, Glucocorticoid
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