title: Development of injectable biocomposites from hyaluronic acid and bioactive glass nano-particles obtained from different sol-gel routes.
abstract: Bioactive glass nano-powders with the same chemical composition and different particle characteristics were synthesized by acid-catalyzed (the glass is called BG1) and acid-base catalyzed (BG2) sol-gel processes. Morphological characteristics of powders were determined by TEM and BET methods. The powders were separately mixed with 3% hyaluronic acid solution to form a paste. In vitro reactivity of pastes was determined by soaking them in simulated body fluid. Rheological behaviors of paste in both rotation and oscillation modes were also measured. The results showed that BG1 particles was microporous with mean pore diameter of 1.6 nm and particle size of ~300 nm while BG2 was mesoporous with average pore diameter of 8 and 17 nm and particle size of 20-30 nm. The paste made of BG2 revealed better washout resistance and in vitro apatite formation ability than BG1. According to the rheological evaluations, both pastes exhibited shear thinning but non-thixotropic behavior, meanwhile paste of BG2 had higher viscosity than BG1. The oscillatory tests revealed that the pastes were viscoelastic materials with more viscous nature. Both pastes could be completely injected through standard syringe using low compressive load of 5-50 N. Overall, The biocomposites can potentially be used as bioactive paste for the treatment of hard and even soft tissues.
authors.affiliation: Nanotechnology and Advanced Materials Department, Materials & Energy Research Center, Alborz, Iran.
authors.forename: Mehri
authors.initials: M
authors.lastname: Sohrabi
authors.forename: Saeed
authors.initials: S
authors.lastname: Hesaraki
authors.forename: Asghar
authors.initials: A
authors.lastname: Kazemzadeh
authors.forename: Masoud
authors.initials: M
authors.lastname: Alizadeh
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D002118:Calcium / Q000032:analysis; D004055:Differential Thermal Analysis; D005898:Glass / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007267:Injections; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D044367:Phase Transition; D016062:Porosity; D011208:Powders; D012212:Rheology; D033081:Shear Strength; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors; D014783:Viscosity; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D011208:Powders; D012996:Solutions; D006820:Hyaluronic Acid; D002118:Calcium
keywords: Bioactive glass; Hydroxyapatite; Injectability; Nano-composite; Rheology