title: Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly.
abstract: Long chain polyunsaturated fatty acids (LC-PUFA), especially the Omega 3, modulate key functions in the body. Their circulating levels are representative of their "status", and may vary at different ages. We have compared the FA status in Italian subjects from neonates to adulthood, assessed through FA analysis of blood drops from fingertips. Data from four cohorts of Italian subjects (total number 1835), have been pooled in four age-groups: neonates (4 days, n=81), children (2-9 years, n=728), adults (40-59 years, n=434) and elderly (60-79 years, n=592). LC-PUFA of both series (Omega 3 and 6) are higher in the blood of neonates than at subsequent ages, reflecting the efficient transfer of these FA from mothers to the fetus. In contrast, the lowest levels of Omega 3 PUFA, especially of DHA, are found in children, probably reflecting inadequate dietary intakes, with possible consequences on the health status at subsequent ages.
authors.affiliation: DiSFeB, Department of Pharmacological and Biomolecular Sciences, University of Milan, via Balzaretti 9, Milan, Italy. Electronic address: patrizia.rise@unimi.it.
authors.forename: P
authors.initials: P
authors.lastname: Risé
authors.forename: E
authors.initials: E
authors.lastname: Tragni
authors.forename: S
authors.initials: S
authors.lastname: Ghezzi
authors.forename: C
authors.initials: C
authors.lastname: Agostoni
authors.forename: F
authors.initials: F
authors.lastname: Marangoni
authors.forename: A
authors.initials: A
authors.lastname: Poli
authors.forename: A L
authors.initials: AL
authors.lastname: Catapano
authors.forename: A
authors.initials: A
authors.lastname: Siani
authors.forename: L
authors.initials: L
authors.lastname: Iacoviello
authors.forename: C
authors.initials: C
authors.lastname: Galli
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016718:Arachidonic Acid / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005229:Fatty Acids, Monounsaturated / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D019787:Linoleic Acid / Q000097:blood; D008875:Middle Aged
chemical_list: D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D016718:Arachidonic Acid; D019787:Linoleic Acid
keywords: AA; ALA; Adults; Blood lipids; Children; DHA; EPA; Elderly; FA; Fatty acid status; LA; LC-PUFA; MUFA; Neonates; PL; Polyunsaturated fatty acids; SFA; WB; alpha-linolenic acid; arachidonic acid; docosahexaenoic acid; eicosapentaenoic acid; fatty acids; linoleic acid; long-chain polyunsaturated fatty acids; monounsaturated fatty acids; phospholipids; saturated fatty acids; whole blood