title: Treatment strategy for cutaneous apocrine carcinoma.
abstract: BACKGROUND
  Cutaneous apocrine carcinoma (CAC) is a rare adnexal carcinoma with only scattered reports about long-term follow-up. The aim of this study is to demonstrate clinical findings in the prognosis of CAC and discuss the treatment procedure.
  
  
  METHODS
  The subjects were nine patients with a histological diagnosis of CAC who underwent wide excision and regional lymph node dissection as the initial treatment at Shizuoka Cancer Center Hospital. We examined the gender, age, site of involvement, additional treatment to prevent recurrence/metastasis, additional treatment after metastasis, and the follow-up data of the study patients. Then, we calculated the recurrence and 5-year (overall/recurrence-free) survival rates.
  
  
  RESULTS
  The men-to-women ratio was 8:1. The patients ranged in age from 47 to 81 years (median, 67 years). The primary lesion was in the axilla in five patients and in the vulva in the other four patients. The follow-up period ranged from 9 to 204 months (median, 44 months). The recurrence-free 5-year survival rate was 63 %, and the overall 5-year survival rate was 75 %.
  
  
  CONCLUSIONS
  We recommend wide local excision for a primary lesion and prophylactic regional lymph node dissection at initial therapy because of the high frequency of regional metastasis of CAC. Although CAC responds poorly to chemotherapy and radiotherapy, adjuvant radiotherapy may be used in advanced local or regional disease.
authors.affiliation: Department of Dermatology, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan, dai.ogata@gmail.com.
authors.forename: Dai
authors.initials: D
authors.lastname: Ogata
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kiyohara
authors.forename: Shusuke
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Masako
authors.initials: M
authors.lastname: Kasami
mesh_terms: D000291:Adnexal Diseases / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D001050:Apocrine Glands / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D009367:Neoplasm Staging
references.citation: Am J Surg Pathol. 2008 May;32(5):682-90
references.pmid: 18347508
references.citation: Scand J Plast Reconstr Surg Hand Surg. 1989;23(2):157-8
references.pmid: 2814387
references.citation: Cancer. 1993 Jan 15;71(2):375-81
references.pmid: 7678545