title: Impact of human papillomavirus on oropharyngeal cancer biology and response to therapy: implications for treatment.
abstract: Oropharyngeal squamous cell carcinoma (OPSCC) originating from human papillomavirus infection has emerged as a new entity in head and neck cancer, defining a subset of patients with distinct carcinogenesis, risk factor profiles, and clinical presentation that show markedly improved survival than patients with classic OPSCC. De-escalation of therapy and identification of relevant biomarkers to aid in patient selection are actively being investigated. This review addresses the implications of these findings in clinical care.
authors.affiliation: Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
authors.forename: Juliana
authors.initials: J
authors.lastname: Bonilla-Velez
authors.forename: Edmund A
authors.initials: EA
authors.lastname: Mroz
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Hammon
authors.forename: James W
authors.initials: JW
authors.lastname: Rocco
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy* / Q000821:virology*; D006801:Humans; D009856:Oncogene Proteins, Viral; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology*; D027383:Papillomaviridae / Q000502:physiology*; D030361:Papillomavirus Infections / Q000473:pathology* / Q000628:therapy; D053918:Papillomavirus Vaccines
chemical_list: D000970:Antineoplastic Agents; D009856:Oncogene Proteins, Viral; D053918:Papillomavirus Vaccines
keywords: Clinical implications; HPV-positive oropharyngeal cancer; Treatment implications
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