title: Prevalence of associated disorders in Indian patients with celiac disease.
abstract: Celiac disease (CD) is an immune-mediated disorder that may be associated with various diseases that share a similar pathogenic immune mechanism. This study reports on the prevalence of various diseases in a cohort of CD patients in northern India. Patients diagnosed with CD based on modified ESPGHAN criteria were prospectively evaluated for associated concomitant diseases. Of the 363 patients evaluated, 207 (57.0 %) were male. The mean age was 19 years. Seventy-one percent of patients presented with typical diarrheal disease, while 29 % presented with atypical nondiarrheal disease. One or more associated diseases were noted in 70 (19.2 %) patients. Liver diseases were the most common association. Portal hypertension was present in 33 (9 %) patients; chronic liver disease was the underlying cause in 17 patients, while noncirrhotic causes were noted in 16 patients. Type 1 diabetes was seen in 13 and hypothyroidism in 11 patients. Other unreported or rarely reported associated diseases were also found in some of the patients. Associated comorbid diseases are common, and may need to be actively screened, in Indian CD patients.
authors.affiliation: Department of Gastroenterology, Sawai Man Singh Medical College, J L N Marg, Jaipur 302 004, India. dr_nijhawan@yahoo.com
authors.forename: Sandeep
authors.initials: S
authors.lastname: Nijhawan
authors.forename: Prashant
authors.initials: P
authors.lastname: Katiyar
authors.forename: Neeraj
authors.initials: N
authors.lastname: Nagaich
authors.forename: Vimal
authors.initials: V
authors.lastname: Saradava
authors.forename: Manisha
authors.initials: M
authors.lastname: Nijhawan
authors.forename: Gaurav
authors.initials: G
authors.lastname: Gupta
authors.forename: Amit
authors.initials: A
authors.lastname: Mathur
authors.forename: Radha
authors.initials: R
authors.lastname: Sharma
authors.forename: Subhash
authors.initials: S
authors.lastname: Nepalia
mesh_terms: D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000178:diet therapy / Q000453:epidemiology*; D002648:Child; D015897:Comorbidity; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D055050:Diet, Gluten-Free; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000453:epidemiology*; D007037:Hypothyroidism / Q000453:epidemiology*; D007194:India / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D055815:Young Adult
references.citation: Scand J Gastroenterol. 1988 Oct;23(8):1000-4
references.pmid: 3201123
references.citation: N Engl J Med. 2002 Jan 17;346(3):180-8
references.pmid: 11796853
references.citation: Indian J Gastroenterol. 2013 Mar;32(2):98-102
references.pmid: 22903368
references.citation: Indian J Gastroenterol. 2007 May-Jun;26(3):122-6
references.pmid: 17704578
references.citation: Eur J Gastroenterol Hepatol. 1999 Oct;11(10):1185-94
references.pmid: 10524652
references.citation: Gut. 1997 Apr;40(4):492-6
references.pmid: 9176077
references.citation: Gut. 1994 Sep;35(9):1215-8
references.pmid: 7959226
references.citation: Br J Rheumatol. 1996 Dec;35(12):1314-8
references.pmid: 9010064
references.citation: Gut. 2001 Oct;49(4):502-5
references.pmid: 11559646
references.citation: Am J Gastroenterol. 2001 Mar;96(3):751-7
references.pmid: 11280546
references.citation: Arch Dis Child. 1990 Aug;65(8):909-11
references.pmid: 2205160
references.citation: Gut. 1998 Mar;42(3):362-5
references.pmid: 9577342
references.citation: Epilepsia. 2004 Oct;45(10):1291-3
references.pmid: 15461685
references.citation: Gastroenterology. 1999 Aug;117(2):297-303
references.pmid: 10419909
references.citation: N Engl J Med. 2008 Dec 25;359(26):2767-77
references.pmid: 19073967
references.citation: J Gastroenterol Hepatol. 2011 May;26(5):894-900
references.pmid: 21182543
references.citation: N Engl J Med. 2003 Jun 19;348(25):2517-24
references.pmid: 12815137
references.citation: Indian J Gastroenterol. 2007 Jul-Aug;26(4):162-6
references.pmid: 17986741