title: Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver: a multi-institutional study by the Japan Biliary Association.
abstract: BACKGROUND
  The aim of this study was to determine the clinicopathological features and surgical outcomes of mucinous cystic neoplasm of the liver (MCN) and mucin-producing intraductal papillary neoplasm of the intrahepatic bile duct (M-IPNB).
  
  
  METHODS
  We performed a multi-institutional, retrospective study of patients with MCN or M-IPNB pathologically defined by the presence or absence of an ovarian-like stroma.
  
  
  RESULTS
  The M-IPNB and MCN were diagnosed in 119 and nine patients, respectively. MCN was observed in female patients, while M-IPNB produced symptoms of cholangitis. M-IPNBs were classed as low or intermediate grade in 53 cases, high grade in 23 and invasive carcinoma in 43. Fifty-one of the M-IPNBs were the pancreatobiliary type (PT), 33 were the intestinal type (IT), 23 were the oncocytic type (OT), and 12 were the gastric type (GT). The 1-, 5- and 10-year survival rates for the 105 patients with M-IPNB were 96%, 84% and 81%, respectively, while the 5-year survival rate for patients with MCN was 100%. OT and GT M-IPNB had better 10-year survival rates than PT and IT M-IPNB.
  
  
  CONCLUSIONS
  Although MCN has different features from M-IPNB, both diseases have a good prognosis after resection. The cellular type of M-IPNB appears to predict outcome.
authors.affiliation: Second Department of Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0283, Japan. kubotak@dokkyomed.ac.jp.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kubota
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma
authors.forename: Fukuo
authors.initials: F
authors.lastname: Kondo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hachiya
authors.forename: Masaru
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Masato
authors.initials: M
authors.lastname: Nagino
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Isayama
authors.forename: Masami
authors.initials: M
authors.lastname: Tabata
authors.forename: Hisafumi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Terumi
authors.initials: T
authors.lastname: Kamisawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Inui
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D018282:Cystadenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D009077:Mucins
keywords: Mucin-producing intraductal papillary neoplasm of the intrahepatic bile duct; Mucinous cystic neoplasm of the liver; Mucobilia; Ovarian-like stroma