title: Endothelial microparticles: sophisticated vesicles modulating vascular function.
abstract: Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.
authors.affiliation: Trinity Biomedical Science Institute (TBSI), Dublin, Ireland. acurtis@tcd.ie
authors.forename: Anne M
authors.initials: AM
authors.lastname: Curtis
authors.forename: Jay
authors.initials: J
authors.lastname: Edelberg
authors.forename: Rebecca
authors.initials: R
authors.lastname: Jonas
authors.forename: Wade T
authors.initials: WT
authors.lastname: Rogers
authors.forename: Jonni S
authors.initials: JS
authors.lastname: Moore
authors.forename: Wajihuddin
authors.initials: W
authors.lastname: Syed
authors.forename: Emile R
authors.initials: ER
authors.lastname: Mohler
mesh_terms: D000818:Animals; D002450:Cell Communication; D055252:Cell-Derived Microparticles / Q000378:metabolism* / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D015398:Signal Transduction; D014652:Vascular Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
keywords: endothelial dysfunction; endothelial microparticles; therapeutics; vesiculation
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