title: Synchronous apoptosis in established tumors leads to the induction of adaptive immunity.
abstract: Understanding the immune response to the death of malignant cells is critical for the development of therapeutic strategies designed to stimulate the immune system against cancer. We have developed an inducible caspase-3-mediated death switch model to explore the effects of apoptosis on the host immune system, demonstrating that the synchronous apoptotic demise of established tumors can be immunogenic and elicit anticancer T-cell responses.
authors.affiliation: Targeted Therapy Group; Institute of Cancer Science; Paterson Institute for Cancer Research; Manchester University; Manchester Cancer Research Centre; Manchester Academic Health Sciences Centres; Manchester UK.
authors.forename: Jamie
authors.initials: J
authors.lastname: Honeychurch
authors.forename: Caroline
authors.initials: C
authors.lastname: Dive
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Illidge
keywords: HMGB1; apoptosis; cancer; caspase 3; death switch; immunogenic cell death
references.citation: Nat Med. 2007 Jan;13(1):54-61
references.pmid: 17187072
references.citation: Nat Med. 2009 Oct;15(10):1170-8
references.pmid: 19767732
references.citation: J Biol Chem. 1998 Apr 24;273(17):10107-11
references.pmid: 9553057
references.citation: Cancer Metastasis Rev. 2011 Mar;30(1):61-9
references.pmid: 21249425
references.citation: Nat Med. 2007 Sep;13(9):1050-9
references.pmid: 17704786
references.citation: Oncoimmunology. 2012 Nov 1;1(8):1323-1343
references.pmid: 23243596
references.citation: Nature. 2000 Oct 12;407(6805):784-8
references.pmid: 11048729
references.citation: Nat Protoc. 2006;1(2):803-11
references.pmid: 17406311
references.citation: Cell Death Differ. 2013 May;20(5):765-73
references.pmid: 23412345
references.citation: Trends Immunol. 2006 May;27(5):244-50
references.pmid: 16584921