title: Vitamin D - pivotal nutraceutical in the regulation of cancer metastasis and angiogenesis.
abstract: Various epidemiological studies have demonstrated that vitamin D may play important roles in the pathogenesis and progression of cancer. Vitamin D is one of the most pivotal nutraceuticals whose active metabolite, calcitriol (1,25-dihydroxyvitamin D3), possesses anti-proliferative, pro-apoptotic, and pro-differentiating capabilities. Accumulating evidence indicates that the potential benefits of using vitamin D in cancer are not only anti-cancer cell proliferation which is linked with its anti-inflammatory effects, including the suppression of prostaglandin metabolism and inhibition of NF-κB signaling, but also suppressing tumor metastasis and angiogenesis. Here, we present a systematic summary of the effects of vitamin D in the chemoprevention and chemotherapy of cancer, especially anti-metastatic and anti-angiogenic actions.
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, China. qyma56@mail.xjtu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jiguang
authors.initials: J
authors.lastname: Ma
authors.forename: Jiangbo
authors.initials: J
authors.lastname: Liu
authors.forename: Huanchen
authors.initials: H
authors.lastname: Sha
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhou
authors.forename: Fengfei
authors.initials: F
authors.lastname: Wang
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Ma
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy / Q000517:prevention & control*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D018167:Receptors, Calcitriol / Q000378:metabolism; D047488:Retinoid X Receptors / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D018167:Receptors, Calcitriol; D047488:Retinoid X Receptors; C579457:VDR protein, human; D014807:Vitamin D