title: Impact of oral meloxicam administration before and after band castration on feedlot performance and behavioral response in weanling beef bulls.
abstract: Two experiments evaluated the effects of band castration and oral administration of an analgesic in association with castration on performance and behavioral and physiological responses in yearling beef bulls. In Exp. 1 Angus and Charolais-crossbred bull calves (n = 127; 309.8 ± 59.04 kg BW) and in Exp. 2 Hereford, Angus, and Hereford × Angus crossbred bulls (n = 30; 300.8 ± 4.96 kg BW) were stratified by BW and randomly assigned to 1 of 3 treatments: 1) band castration (BAND), 2) band castration with oral administration of meloxicam (BAND-MEL), and 3) sham castration (SHAM). The BAND and SHAM procedures were completed on d 0. The SHAM treatment consisted of all animal manipulations associated with band castration without band application. Meloxicam was administered on d -1, 0, and 1 (1.0, 0.5, and 0.5 mg/kg, respectively) via an oral bolus. Body weight and a subjective chute score (CS) were collected on d -1, 0, 1, 7, 14, and 21 (d 28 Exp. 1 only). In Exp. 2, jugular blood samples were collected immediately before castration and 24 h postcastration for substance P (SP) analysis. In Exp. 2, video documentation on d 0 was used to determine range of vertical head motion (DIST) on a subset of animals during treatment administration. In both experiments, ADG was similar (P ≥ 0.50) between BAND and BAND-MEL, but ADG in SHAM cattle was greater (P < 0.001) and tended (P = 0.07) to be greater than castrates in Exp. 1 and 2, respectively. In Exp. 1, CS did not differ (P ≥ 0.26) between BAND and BAND-MEL on any day, but castrates exhibited less desirable CS on d 1 and 28 than SHAM cattle. In Exp. 2, CS was not affected (P ≥ 0.41) by castration or the presence of meloxicam. In Exp. 2, DIST did not differ (P = 0.57) between BAND and BAND-MEL, but when pooled, castrates exhibited greater (P = 0.04) DIST than SHAM. In Exp. 2, plasma SP concentrations were similar between BAND and BAND-MEL (P = 0.81) and between castrates vs. sham cattle (P = 0.67). Results indicate no impact of meloxicam administration on performance or behavioral and physiological responses to band castration. However, there was a negative impact of castration on ADG and DIST.
authors.affiliation: Department of Animal Sciences, Colorado State University, Fort Collins 80523.
authors.forename: P E
authors.initials: PE
authors.lastname: Repenning
authors.forename: J K
authors.initials: JK
authors.lastname: Ahola
authors.forename: R J
authors.initials: RJ
authors.lastname: Callan
authors.forename: J T
authors.initials: JT
authors.lastname: French
authors.forename: R L
authors.initials: RL
authors.lastname: Giles
authors.forename: B J
authors.initials: BJ
authors.lastname: Bigler
authors.forename: J F
authors.initials: JF
authors.lastname: Coetzee
authors.forename: L W
authors.initials: LW
authors.lastname: Wulf
authors.forename: R K
authors.initials: RK
authors.lastname: Peel
authors.forename: J C
authors.initials: JC
authors.lastname: Whittier
authors.forename: J T
authors.initials: JT
authors.lastname: Fox
authors.forename: T E
authors.initials: TE
authors.lastname: Engle
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001522:Behavior, Animal; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D006799:Housing, Animal; D008297:Male; D000077239:Meloxicam; D009919:Orchiectomy / Q000379:methods / Q000662:veterinary*; D010146:Pain / Q000517:prevention & control / Q000662:veterinary*; D013843:Thiazines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D013997:Time Factors; D014886:Weaning
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam