title: Brain areas and pathways in the regulation of glucose metabolism.
abstract: Glucose is the most important source of fuel for the brain and its concentration must be kept within strict boundaries to ensure the organism's optimal fitness. To maintain glucose homeostasis, an optimal balance between glucose uptake and glucose output is required. Besides managing acute changes in plasma glucose concentrations, the brain controls a daily rhythm in glucose concentrations. The various nuclei within the hypothalamus that are involved in the control of both these processes are well known. However, novel studies indicate an additional role for brain areas that are originally appreciated in other processes than glucose metabolism. Therefore, besides the classic hypothalamic pathways, we will review cortico-limbic brain areas and their role in glucose metabolism.
authors.affiliation: Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: Charlene
authors.initials: C
authors.lastname: Diepenbroek
authors.forename: Mireille J
authors.initials: MJ
authors.lastname: Serlie
authors.forename: Eric
authors.initials: E
authors.lastname: Fliers
authors.forename: Andries
authors.initials: A
authors.lastname: Kalsbeek
authors.forename: Susanne E
authors.initials: SE
authors.lastname: la Fleur
mesh_terms: D000818:Animals; D001786:Blood Glucose; D050260:Carbohydrate Metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D007328:Insulin / Q000502:physiology; D015398:Signal Transduction
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose
keywords: cortico-limbic brain areas; glucose metabolism; hypothalamus