title: Investigation of emulsified, acid and acid-alkali catalyzed mesoporous bioactive glass microspheres for bone regeneration and drug delivery.
abstract: Acid-catalyzed mesoporous bioactive glass microspheres (MBGMs-A) and acid-alkali co-catalyzed mesoporous bioactive glass microspheres (MBGMs-B) were successfully synthesized via combination of sol-gel and water-in-oil (W/O) micro-emulsion methods. The structural, morphological and textural properties of mesoporous bioactive glass microspheres (MBGMs) were characterized by various techniques. Results show that both MBGMs-A and MBGMs-B exhibit regularly spherical shape but with different internal porous structures, i.e., a dense microstructure for MBGMs-A and internally porous structure for MBGMs-B. (29)Si NMR data reveal that MGBMs have low polymerization degree of silica network. The in vitro bioactivity tests indicate that the apatite formation rate of MBGMs-B was faster than that of MBGMs-A after soaking in simulated body fluid (SBF) solution. Furthermore, the two kinds of MBGMs have similar storage capacity of alendronate (AL), and the release behaviors of AL could be controlled due to their unique porous structure. In conclusion, the microspheres are shown to be promising candidates as bone-related drug carriers and filling materials of composite scaffold for bone repair.
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 China.
authors.forename: Guohou
authors.initials: G
authors.lastname: Miao
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Dong
authors.forename: Liming
authors.initials: L
authors.lastname: Fang
authors.forename: Cong
authors.initials: C
authors.lastname: Mao
authors.forename: Yuli
authors.initials: Y
authors.lastname: Li
authors.forename: Zhengmao
authors.initials: Z
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Hu
mesh_terms: D000143:Acids / Q000494:pharmacology*; D019386:Alendronate / Q000494:pharmacology*; D000468:Alkalies / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology; D001826:Body Fluids / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects*; D002118:Calcium / Q000032:analysis; D002384:Catalysis / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry*; D016503:Drug Delivery Systems; D004655:Emulsions; D005898:Glass / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009584:Nitrogen; D010316:Particle Size; D010758:Phosphorus / Q000032:analysis; D016062:Porosity; D012825:Silicon / Q000032:analysis; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000143:Acids; D000468:Alkalies; D001672:Biocompatible Materials; D004655:Emulsions; C416205:calcium oxide-silicon dioxide-diphosphorus pentoxide glass; D010758:Phosphorus; D009584:Nitrogen; D002118:Calcium; D019386:Alendronate; D012825:Silicon
keywords: Bioactivity; Bone repair; Drug delivery; Emulsion; Hydroxyapatite; Mesoporous bioactive glasses