title: Peptide sharing between Bordetella pertussis proteome and human sudden death proteins: a hypothesis for a causal link.
abstract: OBJECTIVE
  To explore the molecular basis of the relationship between Bordetella pertussis infection and sudden death.
  
  
  METHODS
  B. pertussis proteins were analyzed for amino acid sequence identity to a set of 67 human proteins that, when altered, have been associated with sudden death.
  
  
  RESULTS
  More than 82,000 pentapeptides are shared between B. pertussis proteins and sudden death-associated antigens.
  
  
  CONCLUSIONS
  Results suggest that a possible link between B. pertussis infection and sudden death might be represented by potential immunological cross-reactions occurring between B. pertussis proteins and human proteins associated to sudden death.
authors.affiliation: Department of Biosciences, Biotechnologies & Biopharmaceutics, University of Bari, Bari, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Capone
authors.forename: Darja
authors.initials: D
authors.lastname: Kanduc
mesh_terms: D000907:Antibodies, Bacterial / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001426:Bacterial Proteins / Q000032:analysis* / Q000276:immunology; D001886:Bordetella pertussis / Q000737:chemistry* / Q000276:immunology; D003429:Cross Reactions; D003645:Death, Sudden / Q000209:etiology*; D006801:Humans; D010455:Peptides / Q000032:analysis* / Q000276:immunology; D020543:Proteome / Q000032:analysis*; D017386:Sequence Homology, Amino Acid
chemical_list: D000907:Antibodies, Bacterial; D001323:Autoantibodies; D001426:Bacterial Proteins; D010455:Peptides; D020543:Proteome