title: Seropositivity and risk factors for herpes simplex virus type 2 infection among female sex workers in Guangxi, China.
abstract: OBJECTIVE
  To determine seropositivity of herpes simplex virus type 2 (HSV-2) infection and associated risk factors among female sex workers (FSWs) in Guangxi, China.
  
  
  METHODS
  A convenience sample of FSWs was recruited from different types of sex work venues in two cities (Wuzhou and Hezhou) in Guangxi. Blood specimens were collected for ELISA-based detection of HSV-2 antibodies to examine the seropositivity of HSV-2 infection. Socio-demographic and behavioral data were collected through a structured questionnaire interview. Association of HSV-2 seropositivity with socio-demographic and behavioral characteristics and HIV status was analyzed.
  
  
  RESULTS
  The overall prevalence of HSV-2 seropositivity among 2453 FSWs was 54.9% (95% confidence interval [CI], 52.9-56.9%). The HSV-2 seropositivity was independently associated with older age, low education level, non-Han minority, migration status, working in lower-tier venues and positive HIV status.
  
  
  CONCLUSIONS
  The study indicates a high prevalence of HSV-2 infection among FSWs, particularly in those working in low-tier venues in study areas, suggesting the needs to further emphasize the inclusion of HSV-2 in surveillance and intervention programs in this population.
authors.affiliation: National Center for STD Control, and the Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China.
authors.forename: Shaochun
authors.initials: S
authors.lastname: Chen
authors.forename: Yueping
authors.initials: Y
authors.lastname: Yin
authors.forename: Xiangsheng
authors.initials: X
authors.lastname: Chen
authors.forename: Hongchun
authors.initials: H
authors.lastname: Wang
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Yu
authors.forename: Wanhui
authors.initials: W
authors.lastname: Wei
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
authors.forename: Ning
authors.initials: N
authors.lastname: Jiang
authors.forename: Baoxi
authors.initials: B
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D002947:Cities / Q000453:epidemiology; D005260:Female; D006558:Herpes Genitalis / Q000453:epidemiology*; D018258:Herpesvirus 2, Human / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D012309:Risk-Taking; D016036:Seroepidemiologic Studies; D060386:Sex Workers / Q000706:statistics & numerical data*; D012959:Socioeconomic Factors; D055815:Young Adult
references.citation: AIDS Educ Prev. 2006 Aug;18(4):333-47
references.pmid: 16961450
references.citation: N Engl J Med. 2007 Feb 22;356(8):854-6
references.pmid: 17314346
references.citation: BMJ. 1994 Nov 19;309(6965):1325-9
references.pmid: 7866079
references.citation: J Infect Dis. 2012 Sep 15;206(6):907-14
references.pmid: 22807520
references.citation: Ann Intern Med. 2005 Nov 15;143(10):707-13
references.pmid: 16287791
references.citation: Sex Health. 2004;1(3):141-4
references.pmid: 16335301
references.citation: Nat Med. 2009 Aug;15(8):886-92
references.pmid: 19648930
references.citation: Sex Transm Dis. 2008 Jun;35(6):558-65
references.pmid: 18354344
references.citation: J Infect Dis. 2003 Jan 1;187(1):19-25
references.pmid: 12508142
references.citation: Int J STD AIDS. 2008 Oct;19(10):694-7
references.pmid: 18824623
references.citation: Arch Intern Med. 2009 Jul 13;169(13):1233-40
references.pmid: 19597073
references.citation: J Infect Dis. 2007 May 1;195(9):1260-9
references.pmid: 17396994
references.citation: AIDS Patient Care STDS. 2005 Dec;19(12):853-60
references.pmid: 16375618
references.citation: Chin Med J (Engl). 2010 Dec;123(23):3495-500
references.pmid: 22166538
references.citation: Bull World Health Organ. 2004 Jun;82(6):454-61
references.pmid: 15356939
references.citation: J Infect Dis. 2002 Jan 1;185(1):45-52
references.pmid: 11756980
references.citation: Int J STD AIDS. 2008 Sep;19(9):635-9
references.pmid: 18725558
references.citation: Cell Res. 2005 Nov-Dec;15(11-12):852-7
references.pmid: 16354559
references.citation: AIDS Care. 2011 Jun;23 Suppl 1:37-44
references.pmid: 21660749