title: Toward understanding the genetics of regulatory T cells in ovarian cancer.
abstract: Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.
authors.affiliation: Department of Health Sciences Research; Mayo Clinic; Rochester, MN, USA.
authors.forename: Melissa S
authors.initials: MS
authors.lastname: Derycke
authors.forename: Bridget
authors.initials: B
authors.lastname: Charbonneau
authors.forename: Claudia C
authors.initials: CC
authors.lastname: Preston
authors.forename: Kimberly R
authors.initials: KR
authors.lastname: Kalli
authors.forename: Keith L
authors.initials: KL
authors.lastname: Knutson
authors.forename: David N
authors.initials: DN
authors.lastname: Rider
authors.forename: Ellen L
authors.initials: EL
authors.lastname: Goode
keywords: CD134; CD80; GARP; GITR; LRRC32; OX40; RGS1; TNFRSF18; TNFRSF4; inherited variants; ovarian cancer; regulatory T cells
references.citation: Pharmacol Rev. 2002 Sep;54(3):527-59
references.pmid: 12223533
references.citation: Immunology. 2009 Apr;126(4):466-74
references.pmid: 19278420
references.citation: Nat Rev Immunol. 2004 May;4(5):336-47
references.pmid: 15122199
references.citation: Cytokine Growth Factor Rev. 2008 Jun-Aug;19(3-4):253-62
references.pmid: 18508403
references.citation: Nat Rev Cancer. 2011 Sep 23;11(10):719-25
references.pmid: 21941283
references.citation: Clin Dev Immunol. 2011;2011:430394
references.pmid: 22110524
references.citation: J Exp Med. 2008 Sep 1;205(9):1975-81
references.pmid: 18710931
references.citation: PLoS One. 2013;8(1):e53903
references.pmid: 23382860
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18538-43
references.pmid: 16344461
references.citation: Nat Med. 2004 Sep;10(9):942-9
references.pmid: 15322536