title: Genetic associations with coronary heart disease: meta-analyses of 12 candidate genetic variants.
abstract: OBJECTIVE
  The aim of this study was to evaluate the combined contribution of 12 genetic variants to the risk of coronary heart disease (CHD).
  
  
  METHODS
  Through a comprehensive literature search for genetic variants involved in the CHD association study, we harvested a total of 10 genes (12 variants) for the current meta-analyses. These genes consisted of GPX1 (rs1050450), PPARD (rs2016520), ALOX15 (rs34210653), SELPLG (rs2228315), FCGR2A (rs1801274), CCL5 (rs2107538), CYP1A1 (rs4646903), TP53 (rs1042522), CX37 (rs1764391), and PECAM1 (rs668, rs12953, and rs1131012).
  
  
  RESULTS
  A total of 45 studies among 23,314 cases and 28,430 controls were retrieved for the meta-analyses of 12 genetic variants. The results showed a significant association between the GPX1 rs1050450 polymorphism and CHD (odd ratio (OR)=1.61, 95% confidence interval (CI)=1.25-2.07, P=0.0002). Other meta-analyses of the rest 11 variants suggested a lack of association with the risk of CHD.
  
  
  CONCLUSIONS
  Our results confirmed that GPX1 rs1050450 was associated with susceptibility to CHD in Chinese and Indian populations.
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China; The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315000, China.
authors.forename: Huadan
authors.initials: H
authors.lastname: Ye
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Li
authors.forename: Lingyan
authors.initials: L
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Liao
authors.forename: Leiting
authors.initials: L
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Liming
authors.initials: L
authors.lastname: Xu
authors.forename: Xuting
authors.initials: X
authors.lastname: Xu
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Hangyu
authors.initials: H
authors.lastname: Wu
authors.forename: Yanping
authors.initials: Y
authors.lastname: Le
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liu
authors.forename: Meng
authors.initials: M
authors.lastname: Ye
authors.forename: Changzheng
authors.initials: C
authors.lastname: Dong
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics*; D056726:Genetic Association Studies; D014644:Genetic Variation; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
keywords: (12/15-LOX); (95% CI); (CHD); (CNKI); (GPx); (GWAS); (MAF); (OR); (QC); 12/15-lipoxygenases; 95% confidence interval; China National Knowledge Infrastructure; Coronary heart disease; GPX1; Genome-wide association studies; Glutathione peroxidase; Meta-analysis; Minor allele frequency; Odd ratio; Polymorphism; Quality control