title: Interaction of calcium sulfate with xanthan gum: effect on in vitro bioadhesion and drug release behavior from xanthan gum based buccal discs of buspirone.
abstract: Bioadhesive polymers in buccal drug delivery systems play an important role in delivery of therapeutic drug molecules for local and systemic action. Xanthan gum, a GRAS listed natural polymer was used to design buccal discs of buspirone hydrochloride by direct compression method. Effect of calcium sulfate on bioadhesive and drug release behavior of xanthan gum buccal discs was studied. Varying amount of calcium sulfate (0%, 5%, 10%, 20%, 30%, 40% and 50%, w/w) in combination with xanthan gum was used to prepare buccal bioadhesive discs. Increase in calcium sulfate concentration resulted in faster drug release and decreased the bioadhesive strength of the designed discs. Further, in rheological evaluation it was observed that viscosity of xanthan gum gel reduces with increasing concentration of calcium sulfate. Compatibility of drug with various excipients was assessed using DSC and FTIR techniques.
authors.affiliation: Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India. Electronic address: jaipala@pilani.bits-pilani.ac.in.
authors.forename: A
authors.initials: A
authors.lastname: Jaipal
authors.affiliation: Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.
authors.forename: M M
authors.initials: MM
authors.lastname: Pandey
authors.affiliation: Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.
authors.forename: A
authors.initials: A
authors.lastname: Abhishek
authors.affiliation: Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.
authors.forename: S
authors.initials: S
authors.lastname: Vinay
authors.affiliation: Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.
authors.forename: S Y
authors.initials: SY
authors.lastname: Charde
mesh_terms: D000269:Adhesives; D000284:Administration, Oral; D002065:Buspirone / Q000737:chemistry / Q000494:pharmacology*; D002133:Calcium Sulfate / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D014783:Viscosity / Q000187:drug effects; D014867:Water / Q000737:chemistry
chemical_list: D000269:Adhesives; D005079:Excipients; D011135:Polysaccharides, Bacterial; D014867:Water; D002065:Buspirone; C002563:xanthan gum; D002133:Calcium Sulfate
keywords: Bioadhesion; Buccal discs; Calcium sulfate; Drug delivery; Viscosity; Xanthan gum