title: Intermittent heterochronic plasma exchange as a modality for delaying cellular senescence-a hypothesis.
abstract: The population of baby boomers (age 60-65) is rapidly increasing globally. The aging of the human body is associated with the decline of cellular function which leads to the development of a variety of diseases. The increased demand for health care for the aging population creates significant financial burden to any healthcare system. Developing strategies and health intervention methods to ameliorate this situation is paramount. Experiments utilizing heterochronic parabiosis in mice have demonstrated that replacing the aging cellular milieu with the plasma of a young experimental animal leads to reversal of cellular senescence. This article describes a hypothetical model of intermittent heterochronic plasma exchange in humans as a modality for heterochronic parabiosis in an attempt to delay cellular senescence.
authors.affiliation: Division of Immunotherapy, California Pacific Medical Center, San Francisco, California; Apheresis Care Group and Fresenius Medical Care, San Francisco, California.
authors.forename: Dobri D
authors.initials: DD
authors.lastname: Kiprov
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood* / Q000276:immunology; D000818:Animals; D016922:Cellular Senescence; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D051379:Mice; D008875:Middle Aged; D008954:Models, Biological; D010227:Parabiosis; D010951:Plasma Exchange; D011157:Population Dynamics / Q000639:trends; D012060:Rejuvenation
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: cellular senescence; parabiosis; plasma exchange