title: Expression of moesin and CD44 is associated with poor prognosis in gastric adenocarcinoma.
abstract: OBJECTIVE
  CD44 has been reported as a negative prognostic marker in gastric cancer. It interacts with moesin in epithelial-mesenchymal transition. To date, to our knowledge, there has been no clinical study dealing with the relationship between moesin and gastric adenocarcinoma. We analysed the expression of moesin and CD44 in gastric adenocarcinoma tissue, and correlations with clinicopathological factors.
  
  
  RESULTS
  A retrospective analysis was made of 430 patients who had undergone gastrectomy at the Korea University Guro Hospital between 2002 and 2005 for gastric adenocarcinoma. Using tissue microarray and immunohistochemical staining, moesin expression was observed in 192 (44.7%) cases; it was associated significantly with poorly differentiated histology, invasion depth, lymph node metastasis, lymphatic invasion and advanced pathological TNM stage. CD44 expression was not correlated with clinicopathological features or moesin expression. Moesin expression was a strong predictor of lymph node metastasis in logistic regression analysis. Both moesin expression and CD44 expression were associated significantly with poor overall survival in univariate analysis. Furthermore, in multivariate analysis, moesin and CD44 were independent markers of poor prognosis, along with pathological TNM stage and older patient age.
  
  
  CONCLUSIONS
  Moesin expression and CD44 expression might be useful markers of poor prognosis in gastric adenocarcinoma.
authors.affiliation: Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Woon Yong
authors.initials: WY
authors.lastname: Jung
authors.forename: Youngran
authors.initials: Y
authors.lastname: Kang
authors.forename: Hyunjoo
authors.initials: H
authors.lastname: Lee
authors.forename: Young-Jae
authors.initials: YJ
authors.lastname: Mok
authors.forename: Han Kyeom
authors.initials: HK
authors.lastname: Kim
authors.forename: Aeree
authors.initials: A
authors.lastname: Kim
authors.forename: Baek-Hui
authors.initials: BH
authors.lastname: Kim
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008840:Microfilament Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D008840:Microfilament Proteins; C071058:moesin
keywords: CD44; adenocarcinoma; epithelial-mesenchymal transition; moesin; stomach