title: Tumor-to-tumor metastasis (TTM) of breast carcinoma within a solitary renal angiomyolipoma: a case report.
abstract: Angiomyolipomas of the kidney have been known to harbor malignant neoplasms including renal cell carcinoma. We report a case of a tumor-to-tumor metastasis (TTM) involving metastatic breast carcinoma and angiomyolipoma. The patient was a 67-year-old female with a history of invasive ductal carcinoma of the breast. Follow-up positron emission tomography 9 years later revealed a left renal mass, suspicious for a primary renal neoplasm, as well as a suspicious subpectoral lymph node. An ultrasound-guided needle biopsy of the lymph node demonstrated metastatic breast carcinoma. The patient underwent a left radical nephrectomy. Pathologic examination demonstrated an ill-defined 2cm estrogen receptor (ER)-positive metastatic breast carcinoma within a 6cm angiomyolipoma. To our knowledge, this is the first reported case of metastatic breast carcinoma to a solitary renal angiomyolipoma. This case highlights the importance of a patient's prior history of malignancy, as well as appropriate sampling of renal neoplasms.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States. Electronic address: milon.amin@outlook.com.
authors.forename: Milon
authors.initials: M
authors.lastname: Amin
authors.forename: Lisa
authors.initials: L
authors.lastname: Radkay
authors.forename: Liron
authors.initials: L
authors.lastname: Pantanowitz
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Fine
authors.forename: Anil
authors.initials: A
authors.lastname: Parwani
mesh_terms: D000368:Aged; D018207:Angiomyolipoma / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000556:secondary*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000556:secondary; D009378:Neoplasms, Multiple Primary / Q000473:pathology*
keywords: Angiomyolipoma; Breast; Carcinoma; Collision; Renal