title: Training-induced behavioral and brain plasticity in inhibitory control.
abstract: Deficits in inhibitory control, the ability to suppress ongoing or planned motor or cognitive processes, contribute to many psychiatric and neurological disorders. The rehabilitation of inhibition-related disorders may therefore benefit from neuroplasticity-based training protocols aiming at normalizing inhibitory control proficiency and the underlying brain networks. Current literature on training-induced behavioral and brain plasticity in inhibitory control suggests that improvements may follow either from the development of automatic forms of inhibition or from the strengthening of top-down, controlled inhibition. Automatic inhibition develops in conditions of consistent and repeated associations between inhibition-triggering stimuli and stopping goals. Once established, the stop signals directly elicit inhibition, thereby bypassing slow, top-down executive control and accelerating stopping processes. In contrast, training regimens involving varying stimulus-response associations or frequent inhibition failures prevent the development of automatic inhibition and thus strengthen top-down inhibitory processes rather than bottom-up ones. We discuss these findings in terms of developing optimal inhibitory control training regimens for rehabilitation purposes.
authors.affiliation: Neurology Unit, Department of Medicine, Faculty of Sciences, University of Fribourg Fribourg, Switzerland ; Psychiatry Unit, Department of Medicine, Faculty of Sciences, University of Fribourg Fribourg, Switzerland.
authors.forename: Lucas
authors.initials: L
authors.lastname: Spierer
authors.forename: Camille F
authors.initials: CF
authors.lastname: Chavan
authors.forename: Aurelie L
authors.initials: AL
authors.lastname: Manuel
keywords: frontal; inhibitory control; plasticity; rehabilitation; training
references.citation: J Exp Psychol Gen. 2008 Nov;137(4):649-72
references.pmid: 18999358
references.citation: J Exp Soc Psychol. 2010 Mar 1;46(2):465-468
references.pmid: 20401323
references.citation: Neuroimage. 2003 Nov;20(3):1649-60
references.pmid: 14642475
references.citation: J Cogn Neurosci. 2000 Sep;12(5):721-8
references.pmid: 11054915
references.citation: Acta Psychol (Amst). 1969;30:412-31
references.pmid: 5811531
references.citation: Psychol Sci. 2012 Jul 1;23(7):805-15
references.pmid: 22692336
references.citation: J Cogn Neurosci. 2012 Jun;24(6):1331-43
references.pmid: 21981672
references.citation: J Neurosci. 2006 Jun 14;26(24):6469-72
references.pmid: 16775134
references.citation: J Cogn Neurosci. 2007 Jan;19(1):69-80
references.pmid: 17214564
references.citation: J Neurophysiol. 1996 Jan;75(1):233-47
references.pmid: 8822554
references.citation: Neurosci Biobehav Rev. 2009 May;33(5):631-46
references.pmid: 18835296
references.citation: Percept Mot Skills. 2007 Dec;105(3 Pt 2):1275-88
references.pmid: 18380128
references.citation: Int J Psychophysiol. 2013 Sep;89(3):342-8
references.pmid: 23623953
references.citation: Electroencephalogr Clin Neurophysiol. 1990 Sep;76(3):249-57
references.pmid: 1697256
references.citation: J Neurosci. 2007 Oct 31;27(44):11860-4
references.pmid: 17978025
references.citation: Neuroreport. 1992 Sep;3(9):761-4
references.pmid: 1421133
references.citation: Neuroimage. 2013 Jun;73:225-36
references.pmid: 22484409
references.citation: Int J Psychophysiol. 2013 Mar;87(3):301-12
references.pmid: 23247193
references.citation: Neuroimage. 2010 Apr 15;50(3):1313-9
references.pmid: 20056157
references.citation: Exp Clin Psychopharmacol. 2013 Feb;21(1):8-16
references.pmid: 23181512
references.citation: J Exp Psychol Gen. 2005 May;134(2):163-91
references.pmid: 15869344
references.citation: J Behav Ther Exp Psychiatry. 2011 Sep;42(3):384-8
references.pmid: 21450264
references.citation: Neurosci Lett. 2006 Nov 13;408(2):113-8
references.pmid: 17018246
references.citation: Neuroimage. 2008 Jun;41(2):493-503
references.pmid: 18420424
references.citation: Cortex. 2013 Apr;49(4):1141-7
references.pmid: 23313010
references.citation: Science. 2007 Jul 13;317(5835):215-9
references.pmid: 17626877
references.citation: Trends Cogn Sci. 2004 Apr;8(4):170-7
references.pmid: 15050513
references.citation: Addiction. 2012 Jul;107(7):1280-7
references.pmid: 22296168
references.citation: Appetite. 2012 Aug;59(1):96-9
references.pmid: 22521403
references.citation: Neuroreport. 2002 Nov 15;13(16):2053-7
references.pmid: 12438925
references.citation: Mem Cognit. 2013 May;41(4):611-24
references.pmid: 23263879
references.citation: J Neurosci. 1998 Jul 1;18(13):5026-34
references.pmid: 9634568
references.citation: Proc Natl Acad Sci U S A. 2008 May 13;105(19):6829-33
references.pmid: 18443283
references.citation: Dev Sci. 2009 Jan;12(1):106-13
references.pmid: 19120418
references.citation: Behav Res Ther. 2011 Nov;49(11):771-80
references.pmid: 21906724
references.citation: J Exp Child Psychol. 2008 Aug;100(4):252-63
references.pmid: 18430433
references.citation: J Neural Transm (Vienna). 2008;115(1):127-33
references.pmid: 17885723
references.citation: Behav Brain Funct. 2010 Oct 28;6:66
references.pmid: 21029446
references.citation: Nat Neurosci. 2012 Mar 18;15(4):528-36
references.pmid: 22426254
references.citation: Curr Opin Psychiatry. 2010 May;23(3):267-72
references.pmid: 20308899
references.citation: Psychol Sci. 2007 Apr;18(4):292-7
references.pmid: 17470250
references.citation: Cereb Cortex. 2005 Aug;15(8):1089-102
references.pmid: 15616134
references.citation: Biol Psychiatry. 2011 Jun 15;69(12):e55-68
references.pmid: 20932513
references.citation: Hum Factors. 1988 Oct;30(5):583-98
references.pmid: 3065212
references.citation: Biol Psychiatry. 2005 Jun 1;57(11):1285-92
references.pmid: 15950000
references.citation: J Neurophysiol. 1998 Feb;79(2):817-34
references.pmid: 9463444
references.citation: J Exp Psychol Hum Percept Perform. 1994 Oct;20(5):1015-36
references.pmid: 7964527
references.citation: J Exp Psychol Hum Percept Perform. 1984 Apr;10(2):276-91
references.pmid: 6232345
references.citation: Exp Brain Res. 1991;84(2):393-402
references.pmid: 2065746
references.citation: Hum Brain Mapp. 2010 Jun;31(6):879-90
references.pmid: 20496379
references.citation: Dev Neuropsychol. 2004;26(2):571-93
references.pmid: 15456685
references.citation: Trends Cogn Sci. 2010 Jul;14(7):317-24
references.pmid: 20630350
references.citation: Neuroscientist. 2007 Jun;13(3):214-28
references.pmid: 17519365
references.citation: Psychon Bull Rev. 2008 Feb;15(1):108-15
references.pmid: 18605489
references.citation: Appetite. 2011 Apr;56(2):345-9
references.pmid: 21185896
references.citation: J Neural Transm (Vienna). 2007;114(12):1595-601
references.pmid: 17610122
references.citation: Memory. 2006 Jul;14(5):553-69
references.pmid: 16754241
references.citation: J Neurosci. 2006 Mar 1;26(9):2424-33
references.pmid: 16510720
references.citation: Electroencephalogr Clin Neurophysiol. 1995 Jan;96(1):36-43
references.pmid: 7530187
references.citation: Appl Prev Psychol. 2007 Dec;12(3):99-114
references.pmid: 19050749
references.citation: Brain Res. 1992 Jan 20;570(1-2):134-43
references.pmid: 1617405
references.citation: Psychol Aging. 2008 Dec;23(4):731-42
references.pmid: 19140644
references.citation: Drug Alcohol Depend. 2011 Jul 1;116(1-3):132-6
references.pmid: 21288663
references.citation: J Cogn Neurosci. 2012 Sep;24(9):1908-18
references.pmid: 22624606
references.citation: Neuropsychol Rev. 2007 Sep;17(3):337-45
references.pmid: 17680368
references.citation: J Exp Psychol Gen. 2004 Mar;133(1):101-135
references.pmid: 14979754
references.citation: Annu Rev Neurosci. 1997;20:303-30
references.pmid: 9056716
references.citation: Neuroimage. 2001 Feb;13(2):250-61
references.pmid: 11162266
references.citation: Atten Defic Hyperact Disord. 2012 Mar;4(1):11-23
references.pmid: 22179720
references.citation: Science. 2001 Jan 12;291(5502):260-3
references.pmid: 11253215
references.citation: Int J Obes (Lond). 2008 Apr;32(4):708-14
references.pmid: 18059403
references.citation: Cognition. 2009 May;111(2):275-9
references.pmid: 19285310
references.citation: J Neurosci. 2010 Oct 13;30(41):13670-8
references.pmid: 20943907
references.citation: Psychol Aging. 2008 Dec;23(4):720-30
references.pmid: 19140643
references.citation: J Exp Psychol. 1966 Feb;71(2):264-72
references.pmid: 5948188
references.citation: Cereb Cortex. 2008 Aug;18(8):1923-32
references.pmid: 18245044
references.citation: Science. 2012 Sep 21;337(6101):1492-5
references.pmid: 22997327
references.citation: Mem Cognit. 2000 Jan;28(1):8-17
references.pmid: 10714133
references.citation: Psychol Aging. 2004 Dec;19(4):581-91
references.pmid: 15584784
references.citation: Acta Psychol (Amst). 1999 Apr;101(2-3):267-91
references.pmid: 10344188
references.citation: J Cogn Neurosci. 2011 Nov;23(11):3388-99
references.pmid: 21452946
references.citation: Psychol Med. 2002 Feb;32(2):287-97
references.pmid: 11866323
references.citation: Nat Neurosci. 2004 Jan;7(1):75-9
references.pmid: 14699419
references.citation: Acta Psychol (Amst). 2003 Feb;112(2):105-42
references.pmid: 12521663
references.citation: Neuropsychopharmacology. 2010 Jan;35(1):258-77
references.pmid: 19693005
references.citation: Neuropsychologia. 2008 Jan 31;46(2):632-9
references.pmid: 17959204
references.citation: Neuroimage. 2000 Jul;12(1):1-13
references.pmid: 10875897
references.citation: Psychol Rev. 2007 Apr;114(2):376-97
references.pmid: 17500631