title: Hearing loss effects of administering boric alcohol solution prepared with alcohol in various degrees on guinea pigs (an experimental study).
abstract: OBJECTIVE
  To investigate the ototoxic effect of boric acid solution prepared with different degree of alcohol.
  
  
  METHODS
  This study was performed on 28 young albino guinea pigs. After the animals divided four groups prior to the application of the solution an auditory brainstem response (ABR) test was applied to the each animal under general anesthesia. Their tympanic membranes perforated and test solutions were administrated to the middle ear through the perforation. On 15th day, ABR measurements were carried out and comparison was made with preadministration values.
  
  
  RESULTS
  The degrees of hearing loss occurring as a result of the administration of 4% boric alcohol solutions prepared with 60° and 40° alcohol differed significantly (p < 0.001).
  
  
  CONCLUSIONS
  It was established that 4% boric acid solution prepared with 60 alcohol affected hearing in guinea pigs more negatively and an increase in degree of alcohol also increased the ototoxicity of the boric acid solution.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, İzmir Private Su Hospital, İzmir, Turkey.
authors.forename: Sinem
authors.initials: S
authors.lastname: Aktas
authors.forename: Mehmet Sinan
authors.initials: MS
authors.lastname: Basoglu
authors.forename: Hale
authors.initials: H
authors.lastname: Aslan
authors.forename: Ali Ekber
authors.initials: AE
authors.lastname: Ilknur
authors.forename: Riza
authors.initials: R
authors.lastname: Dundar
authors.forename: Huseyin
authors.initials: H
authors.lastname: Katilmis
authors.forename: Sedat
authors.initials: S
authors.lastname: Ozturkcan
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D001888:Boric Acids / Q000494:pharmacology / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004432:Ear, Middle / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology / Q000633:toxicity*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D006168:Guinea Pigs; D034381:Hearing Loss / Q000139:chemically induced* / Q000175:diagnosis; D007322:Instillation, Drug; D011897:Random Allocation; D012016:Reference Values
chemical_list: D001888:Boric Acids; D004338:Drug Combinations; D000431:Ethanol; C032688:boric acid
keywords: ABRs; Boric alcohol solution; Ototopical use; Ototoxicity