title: [Treatment of premature ovarian failure by bushen huoxue recipe combined estrogen and progesterone: a clinical research].
abstract: OBJECTIVE
  To observe the clinical efficacy of bushen huoxue recipe (BHR) combined estrogen and progesterone in treating premature ovarian failure (POF), and to explore an effective treatment program of POF by integrative medicine.
  
  
  METHODS
  Totally 265 POF patients were randomly assigned to 3 groups, i.e., Group I (86 cases, treated by BHR),Group II (88 cases,treated by conjugated estrogens and medroxyprogesterone acetate), and Group III (91 cases,treated by BHR +conjugated estrogens and medroxyprogesterone acetate). The therapeutic course for each group was 6 months. The main symptoms (including menstrual cycle, hectic fever, night sweat, vaginal dryness, and low libido), laboratory indices [including follicle stimulating hormone (FSH), luteotropic hormone (LH), estradiol (E2), and inhibin B (INH-B)], B-ultrasound indicators (including endometrial thickness, ovarian volume, and antral follicle count), and adverse reactions were observed in the three groups at the end of treatment and 6 months after treatment.
  
  
  RESULTS
  Compared with before treatment, the main symptoms, laboratory indices, and B-ultrasound indicators were statistically improved in the three groups at the end of treatment and 6 months after treatment (P <0.05, P <0.01). Better effects were obtained in Group III in improving symptoms of the menstrual cycle, vaginal dryness, and low libido, lowering levels of FSH and LH, elevating levels of E2and INH-B, and ameliorating the endometrial thickness, the ovarian volume, and the antral follicle count (P <0.05, P <0.01). No obvious adverse reaction occurred in the three groups.
  
  
  CONCLUSIONS
  BHR combined estrogen and progesterone showed better clinical efficacy than use of BHR or estrogen/progesterone alone, indicating it was an effective treatment program for POF.
authors.affiliation: Department of Integrative Medicine, Hubei Province Hospital of Maternal and Children Health Care, Wuhan 430070, China. jzc88@163.com
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Jin
authors.forename: Xiao-Tao
authors.initials: XT
authors.lastname: Huang
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Yang
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Dan-Juan
authors.initials: DJ
authors.lastname: He
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Liu
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006801:Humans; D055048:Integrative Medicine; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy*; D011374:Progesterone / Q000627:therapeutic use
chemical_list: D004365:Drugs, Chinese Herbal; D004967:Estrogens; C527851:bushen huoxue; D011374:Progesterone