title: Association of plasma visfatin with risk of colorectal cancer: An observational study of Chinese patients.
abstract: OBJECTIVE
  To investigate the association between plasma visfatin levels and risk of early and advanced colorectal cancer (CRC).
  
  
  METHODS
  In total, 358 CRC patients and 286 controls were enrolled. According to the T factor of the TNM system. cancer patients were divided into two subgroups: early and advanced cancer. Levels of visfatin, anthropometric and metabolic parameters, which were classified as low, medium, and high, based on the tertile distributions in the control group, were determined.
  
  
  RESULTS
  The visfatin levels in patients with advanced and early cancer were higher than in controls (least significant difference test, P = 0.004 and 0.013, respectively). The patients in the highest tertile of visfatin concentration presented significantly higher odds for early and advanced CRC, adjusted for potential confounding factors (odds ratio 3.37; 95% CI, 1.93-8.37; P = 0.011; odds ratio 2.38; 95% CI: 1.82-8.35; P = 0.015, respectively). The visfatin level correlated significantly with waist:hip ratio (P < 0.05 for all) among case and control participants. Plasma visfatin levels in early and advanced CRC yielded a receiver operating characteristic curve area of 72 and 86%, respectively. The optimal sensitivity and specificity were 73% and 57% in discriminating between early CRC and normal controls while they were 76% and 68% in discriminating between advanced CRC and normal controls.
  
  
  CONCLUSIONS
  An increased level of visfatin was a strong risk factor for both early and advanced CRC in Chinese patients. Plasma visfatin levels might be a potential biomarker for CRC detection.
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Youming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Division of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Ye
authors.affiliation: Division of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Shenyi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Division of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Changjun
authors.initials: C
authors.lastname: Yu
authors.affiliation: Division of Endoscopy, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Xie
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D016017:Odds Ratio; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: body mass index; colonoscopy; colorectal cancer; insulin resistance; visfatin; waist:hip ratio