title: Cylindroside A, a new triterpenoid saponin from Cylindrokelupha dalatensis and its cytotoxic activity.
abstract: A new triterpenoid saponin, named cylindroside A (1), was isolated from the seeds of Cylindrokelupha dalatensis (Kosterm.) T.L. Wu by using chromatographic method. The structure of 1 was established by comprehensive spectroscopic analysis and chemical degradation. Compound 1 displayed significant antitumor activity in vitro against BCG and MCF-7 cancer cell lines and IC₅₀ values were 4.17 ± 0.23 and 3.07 ± 0.66 μM by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method, respectively.
authors.affiliation: a Department of Pharmacy , Hainan Branch of Chinese People's Liberation Army General Hospital , Hainan , 572013 , China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Shuang
authors.initials: S
authors.lastname: Xing
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Guo-Ling
authors.initials: GL
authors.lastname: Xiong
authors.forename: Qing-Liang
authors.initials: QL
authors.lastname: Luo
authors.forename: Bai-Ping
authors.initials: BP
authors.lastname: Ma
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Yang
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013778:Tetrazolium Salts; D013844:Thiazoles; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; D013778:Tetrazolium Salts; D013844:Thiazoles; D014315:Triterpenes; C586969:cylindroside A; C022616:thiazolyl blue