title: Potential contribution of interleukin-33 to the development of interstitial lung disease in patients with primary Sjogren's Syndrome.
abstract: OBJECTIVE
  To determine whether interleukin (IL)-33 and soluble ST2 (sST2) are associated with primary Sjogren's Syndrome (pSS).
  
  
  METHODS
  Serum levels of IL-33 and sST2 in 110 pSS patients and 78 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA). Immunoglobulins, rheumatoid factors (RF), antinuclear antibody (ANA), anti-SSA/RO-52 antibody, anti-SSB antibody and erythrocyte sedimentation rate (ESR) were measured by standard laboratory techniques. Interstitial lung disease (ILD) was identified on high-resolution computed tomography (HRCT). Disease activity in pSS was scored with the European League Against Rheumatism Sjogren's Syndrome Disease Activity Index (ESSDAI).
  
  
  RESULTS
  Serum levels of IL-33 and sST2 were significantly elevated in pSS patients, especially in patients with ILD. There was significant positive correlation between IL-33 and RF, anti-SSB antibody.
  
  
  CONCLUSIONS
  IL-33/sST2 may be involved in the pathogenesis of pSS and partly contribute to the ILD in pSS patients.
authors.affiliation: Department of Rheumatology, 1st Affiliated Hospital of China Medical University, Shenyang 110001, PR China; Department of Rheumatology, 2nd Affiliated Hospital of Dalian Medical University, Dalian 116021, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
authors.forename: Lutian
authors.initials: L
authors.lastname: Yao
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.forename: Liping
authors.initials: L
authors.lastname: Xia
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D001799:Blood Sedimentation; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins / Q000097:blood* / Q000378:metabolism; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000097:blood* / Q000378:metabolism; D012217:Rheumatoid Factor / Q000097:blood; D012261:Ribonucleoproteins / Q000097:blood / Q000276:immunology; D012859:Sjogren's Syndrome / Q000097:blood* / Q000378:metabolism; D000099207:SS-A Antigen
chemical_list: D000974:Antibodies, Antinuclear; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins; D011956:Receptors, Cell Surface; D012217:Rheumatoid Factor; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C079241:IL1RL1 protein, human; C506536:IL33 protein, human
keywords: Interleukin-33; Interstitial lung disease; Primary Sjogren’s Syndrome; sST2