title: Dextran-functionalized magnetic fluid mediating magnetohyperthermia combined with preventive antioxidant pequi-oil supplementation: potential use against cancer.
abstract: This work aimed to test a dextran-functionalized magnetic fluid (DexMF) sample in mediating magnetohyperthermia to treat an advanced clinical Ehrlich-solid-tumor, to verify the effects of oral antioxidant administration of pequi-oil on this treatment and to investigate the potential of these treatments for future use as an adjuvant in cancer therapy. Animals received the treatments: (a) filtered water (control); (b) tumor implantation and no treatment (tumor group); (c) tumor implantation followed by intratumoral injection of DexMF and alternating current magnetic field exposure (MHT group) for three consecutive days; (d) oral pequi-oil supplementation followed by tumor implantation and the same treatment as group MHT (PMHT group). Analyses took place 1 and 2 weeks after tumor implantation. Both treatments were effective in increasing the tumor necrosis process and controlling tumor growth, besides keeping lymphocyte-dependent immunity. Although the MHT treatment was more efficient after the first week in reducing DNA damage to blood peripheral leucocytes, PMHT therapy appeared to be more effective with the advance of the carcinogenesis process after the second week. Our findings evidence the potential use of DexMF mediating magnetohyperthermia in cancer treatment and also suggest that the preventive pequi oil administration could increase the efficiency of this process.
authors.affiliation: Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil. mirandavilela@unb.br
authors.forename: Ana Luisa
authors.initials: AL
authors.lastname: Miranda-Vilela
authors.forename: Raphael Cândido Apolinário
authors.initials: RC
authors.lastname: Peixoto
authors.forename: Joāo Paulo Figueiró
authors.initials: JP
authors.lastname: Longo
authors.forename: Débora de Oliveira
authors.initials: Dde O
authors.lastname: Silva e Cintra
authors.forename: Flávia Arruda
authors.initials: FA
authors.lastname: Portilho
authors.forename: Kely Lopes Caiado
authors.initials: KL
authors.lastname: Miranda
authors.forename: Patrícia Pommé Confessori
authors.initials: PP
authors.lastname: Sartoratto
authors.forename: Sônia Nair
authors.initials: SN
authors.lastname: Báo
authors.forename: Ricardo Bentes
authors.initials: RB
authors.lastname: de Azevedo
authors.forename: Zulmira Guerrero Marques
authors.initials: ZG
authors.lastname: Lacava
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy / Q000379:methods; D003911:Dextrans / Q000737:chemistry*; D005240:Feasibility Studies; D006979:Hyperthermia, Induced / Q000379:methods*; D055909:Magnetic Field Therapy / Q000379:methods*; D010938:Plant Oils / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D003911:Dextrans; D010938:Plant Oils