title: Dose-response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats.
abstract: The dose-response efficiency and long-term effect of the hypocholesterolemic effect of octadecylpectinamide was examined in female rats fed diets containing cholesterol at 10 g/kg. In our first experiment, amidated pectin supplied at 20 g/kg, 40 g/kg and 60 g/kg significantly decreased serum cholesterol from 3.32 μmol/ml (control) to 1.23 μmol/ml in a dose-dependent manner. In a second experiment, the hypocholesterolemic effect of amidated pectin supplied at 20 g/kg persisted after 3 months of feeding. In both experiments, the amidated pectin significantly decreased the concentrations of cholesterol in hepatic tissue and triacylglycerols in serum. The serum concentration of aspartate aminotransferase significantly increased in rats fed amidated pectin at 60 g/kg for 4 weeks, and at 20 g/kg for 3 months. In conclusion, amidated pectin at a low dose and used for a period shorter than 3 months might be considered as an effective hypocholesterolemic and lipid-lowering agent that may substitute typical antilipidemic drugs.
authors.affiliation: Institute of Animal Science, Prague CZ-104 00, Czech Republic. marounek.milan@vuzv.cz
authors.forename: Milan
authors.initials: M
authors.lastname: Marounek
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Volek
authors.forename: Dagmar
authors.initials: D
authors.lastname: Dušková
authors.forename: Jan
authors.initials: J
authors.lastname: Tůma
authors.forename: Tomáš
authors.initials: T
authors.lastname: Taubner
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010368:Pectins / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; C586539:octadecylpectinamide; D010368:Pectins; D002784:Cholesterol
keywords: Amidated pectin; Cholesterol; Liver; Rats; Serum