title: Maternal bisphenol a exposure during pregnancy and its association with adipokines in Mexican-American children.
abstract: Bisphenol A (BPA) is a high volume production chemical that has been detected in 93% of the United States population. It is thought to have endocrine disrupting activity but human data are limited. In this study, we examined whether prenatal or concurrent urinary BPA concentrations are associated with key metabolism-related hormones, adiponectin and leptin (adipokines), in 9-year-old children. For this analysis, we used 188 mother-child pairs from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) prospective study. BPA was measured in urinary spot samples during early (12.6 ± 3.9 weeks gestation) and late (26.3 ± 2.5 weeks gestation) pregnancy and in 9-year-old children. We found that BPA concentrations during late pregnancy were associated with increased plasma leptin in boys (β = 0.06, P = 0.01), controlling for maternal prepregnancy body mass index (BMI), pregnancy soda consumption, and smoking, years in US prior to pregnancy, maternal education, household poverty status, child BMI and child soda, fast food and sweet snack consumption at 9 years. Additionally, we found that BPA concentrations during early pregnancy are directly associated with plasma adiponectin levels in girls (β = 3.71, P = 0.03). However, we did not find any significant relationships between concurrent BPA concentrations and 9-year child adiponectin or leptin. Overall, our data suggest that prenatal BPA concentrations may influence adipokine levels in 9-year-old children.
authors.affiliation: Center for Environmental Research and Children's Health (CERCH), Environmental Health Sciences, School of Public Health, University of California, Berkeley, California.
authors.forename: Vitaly
authors.initials: V
authors.lastname: Volberg
authors.forename: Kim
authors.initials: K
authors.lastname: Harley
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Calafat
authors.forename: Veronica
authors.initials: V
authors.lastname: Davé
authors.forename: Jessica
authors.initials: J
authors.lastname: McFadden
authors.forename: Brenda
authors.initials: B
authors.lastname: Eskenazi
authors.forename: Nina
authors.initials: N
authors.lastname: Holland
mesh_terms: D054392:Adipokines / Q000097:blood / Q000378:metabolism*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D001559:Benzhydryl Compounds / Q000652:urine*; D002648:Child; D003710:Demography; D004781:Environmental Exposure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D018811:Maternal Exposure; D017058:Mexican Americans; D010636:Phenols / Q000652:urine*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013223:Statistics as Topic; D011795:Surveys and Questionnaires; D000098826:Bisphenol A Compounds
chemical_list: D054392:Adipokines; D052242:Adiponectin; D001559:Benzhydryl Compounds; D020738:Leptin; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: adiponectin; endocrine disruptor; leptin; prenatal; sex-difference
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