title: Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.
abstract: Exposure to bisphenol A (BPA) is implicated in many aspects of metabolic disease in humans and experimental animals. We fed pregnant CD-1 mice BPA at doses ranging from 5 to 50,000μg/kg/day, spanning 10-fold below the reference dose to 10-fold above the currently predicted no adverse effect level (NOAEL). At BPA doses below the NOAEL that resulted in average unconjugated BPA between 2 and 200pg/ml in fetal serum (AUC0-24h), we observed significant effects in adult male offspring: an age-related change in food intake, an increase in body weight and liver weight, abdominal adipocyte mass, number and volume, and in serum leptin and insulin, but a decrease in serum adiponectin and in glucose tolerance. For most of these outcomes non-monotonic dose-response relationships were observed; the highest BPA dose did not produce a significant effect for any outcome. A 0.1-μg/kg/day dose of DES resulted in some but not all low-dose BPA outcomes.
authors.affiliation: Division of Biological Sciences, 114 Lefevre Hall, University of Missouri, Columbia, MO 65211, USA. Electronic address: brittanyangle@mail.missouri.edu.
authors.forename: Brittany M
authors.initials: BM
authors.lastname: Angle
authors.forename: Rylee Phuong
authors.initials: RP
authors.lastname: Do
authors.forename: Davide
authors.initials: D
authors.lastname: Ponzi
authors.forename: Richard W
authors.initials: RW
authors.lastname: Stahlhut
authors.forename: Bertram E
authors.initials: BE
authors.lastname: Drury
authors.forename: Susan C
authors.initials: SC
authors.lastname: Nagel
authors.forename: Wade V
authors.initials: WV
authors.lastname: Welshons
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Besch-Williford
authors.forename: Paola
authors.initials: P
authors.lastname: Palanza
authors.forename: Stefano
authors.initials: S
authors.lastname: Parmigiani
authors.forename: Frederick S
authors.initials: FS
authors.lastname: vom Saal
authors.forename: Julia A
authors.initials: JA
authors.lastname: Taylor
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects; D052242:Adiponectin / Q000097:blood; D000818:Animals; D001559:Benzhydryl Compounds / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002452:Cell Count; D048429:Cell Size; D004435:Eating / Q000187:drug effects; D052244:Endocrine Disruptors / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D010636:Phenols / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D011247:Pregnancy; D000098826:Bisphenol A Compounds
chemical_list: D052242:Adiponectin; D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D005947:Glucose; D007328:Insulin; D020738:Leptin; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Adipocytes; Endocrine disruption; Food intake; Glucose tolerance; Metabolic syndrome
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