title: Clinical features and sera anti-aquaporin 4 antibody positivity in patients with demyelinating disorders of the central nervous system from Tianjin, China.
abstract: OBJECTIVE
  To investigate the clinical characteristics and sera anti-aquaporin 4 (AQP4) antibody positivity in patients with inflammatory demyelinating disorders (IDDs) of the central nervous system (CNS) in Tianjin, China.
  
  
  METHODS
  We retrospectively evaluated 234 patients with IDDs including neuromyelitis optica (NMO), recurrent optic neuritis (rON), longitudinally extensive transverse myelitis (LETM), clinically isolated syndrome (CIS), and multiple sclerosis (MS) groups. Sera from 217 patients were determined for AQP4-Ab. The clinical characteristics and sera anti-AQP4 positivity were compared.
  
  
  RESULTS
  The IDDS comprised 63 MS, 51 NMO, 56 LETM, 10 rON, and 54 CIS. Compared with MS, NMO had a higher frequency of occurrence in women, intractable hiccup and nausea (IHN), medullospinal lesion, longitudinally extensive spinal cord lesions (LESCL) and bilateral ON, disease onset at a later age, and worsening residual disability. AQP4-Ab-positive rates were 84.1% and 69% in NMO and NMO spectrum disorders (NMOSD), respectively, whereas it was undetectable in all of the MS sera samples.
  
  
  CONCLUSIONS
  We comprehensively contrast the distinct clinical features of MS, NMO, and NMOSD in our center. A sensitive AQP4-Ab assay is necessary for the early diagnosis of NMOSD in our patients. Neither medullospinal lesion nor IHN is unique in NMO.
authors.affiliation: Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Chun-Sheng
authors.initials: CS
authors.lastname: Yang
authors.forename: Da-Qi
authors.initials: DQ
authors.lastname: Zhang
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Wang
authors.forename: Wei-Na
authors.initials: WN
authors.lastname: Jin
authors.forename: Min-Shu
authors.initials: MS
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Cun-Jin
authors.initials: CJ
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.forename: Fu-Dong
authors.initials: FD
authors.lastname: Shi
authors.forename: Li
authors.initials: L
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D051401:Aquaporin 4 / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000473:pathology; D002681:China / Q000453:epidemiology; D020278:Demyelinating Autoimmune Diseases, CNS / Q000453:epidemiology* / Q000276:immunology* / Q000473:pathology; D003711:Demyelinating Diseases / Q000453:epidemiology* / Q000276:immunology* / Q000473:pathology; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D009188:Myelitis, Transverse / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D009471:Neuromyelitis Optica / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D009902:Optic Neuritis / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D012189:Retrospective Studies; D013116:Spinal Cord / Q000473:pathology; D055815:Young Adult
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies
keywords: Anti-aquaporin 4 antibody; Chinese; Clinical features; Multiple sclerosis; Neuromyelitis optica
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