title: Spurious elevation of glucose concentration during administration of high dose of ascorbic acid in a patient with type 2 diabetes on hemodialysis.
abstract: We describe herein a case of life-threatening hypoglycemia due to spurious elevation of glucose concentration during the administration of ascorbic acid in a type 2 diabetic patient. A 31-year-old female was admitted for proliferative diabetic retinopathy treatment and prescribed high dose ascorbic acid. During hospitalization, she suddenly lost her consciousness and her glucose concentration was 291 mg/dL, measured using self-monitoring blood glucose (SMBG) device, while venous blood glucose concentration was 12 mg/dL. After intravenous injection of 50% glucose solution, the patient became alert. We reasoned that glucose measurement by SMBG device was interfered by ascorbic acid. Physicians should be aware of this interference; high dose ascorbic acid may cause spurious elevation of glucose concentration when measuring with SMBG devices.
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, 79 Gangnam-ro, Jinju 660-702, Korea.
authors.forename: Soo Kyoung
authors.initials: SK
authors.lastname: Kim
authors.forename: Jong Ryeal
authors.initials: JR
authors.lastname: Hahm
authors.forename: Ho-Su
authors.initials: HS
authors.lastname: Kim
authors.forename: Sungsu
authors.initials: S
authors.lastname: Kim
authors.forename: Tae Sik
authors.initials: TS
authors.lastname: Jung
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Jung
authors.forename: Hye Ryun
authors.initials: HR
authors.lastname: Lee
authors.forename: Deok Ryong
authors.initials: DR
authors.lastname: Kim
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001786:Blood Glucose; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation / Q000592:standards; D000075202:Contraindications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis*; D006435:Renal Dialysis
chemical_list: D001786:Blood Glucose; D001205:Ascorbic Acid
keywords: Self-monitoring of blood glucose; ascorbic acid; hypoglycemia
references.citation: Am J Clin Pathol. 2000 Jan;113(1):75-86
references.pmid: 10631860
references.citation: Sensors (Basel). 2010;10(5):4558-76
references.pmid: 22399892
references.citation: Diabetes Care. 2003 Nov;26(11):3190
references.pmid: 14578265
references.citation: Diabetes Care. 2005 Jun;28(6):1510-7
references.pmid: 15920083
references.citation: Chem Rev. 2008 Jul;108(7):2482-505
references.pmid: 18465900
references.citation: J Diabetes Sci Technol. 2010 Nov 01;4(6):1479-94
references.pmid: 21129345
references.citation: Diabetes Care. 2010 Apr;33(4):728-9
references.pmid: 20351227
references.citation: Diabetes Care. 2004 Sep;27(9):2279
references.pmid: 15333503
references.citation: Isr Med Assoc J. 2010 Feb;12(2):125-6
references.pmid: 20550042
references.citation: Diabetes Care. 2006 Aug;29(8):1764-70
references.pmid: 16873777
references.citation: Curr Med Res Opin. 2006 Nov;22(11):2167-74
references.pmid: 17076977
references.citation: Diabetologia. 2006 Feb;49(2):271-8
references.pmid: 16362814
references.citation: BMJ. 2003 Sep 13;327(7415):608-9
references.pmid: 12969932
references.citation: J Diabetes Sci Technol. 2009 Jul 01;3(4):903-13
references.pmid: 20144340