title: Caged Pt nanoclusters exhibiting corrodibility to exert tumor-inside activation for anticancer chemotherapeutics.
abstract: We report on caged Pt nanoclusters that are able to exert tumor-inside activation for anticancer chemotherapeutics and to minimize systemic toxicity. By shrinking the Pt size to 1 nm, it possesses corrodibility for dissolution in weakly acidic organelles to release toxic Pt ions. The therapeutic effect in exerting tumor-inside activation is confirmed in vivo by post-modifying a pH-cleavable PEG corona and mixing it with a tumor-homing peptide for tumour suppression.
authors.affiliation: Center for Nanomedicine Research, National Health Research Institutes, 35 Keyan Road Zhunan, 35053, Taiwan.
authors.forename: Chih-Te
authors.initials: CT
authors.lastname: Chien
authors.forename: Jia-Ying
authors.initials: JY
authors.lastname: Yan
authors.forename: Wan-Ching
authors.initials: WC
authors.lastname: Chiu
authors.forename: Te-Haw
authors.initials: TH
authors.lastname: Wu
authors.forename: Chia-Yeh
authors.initials: CY
authors.lastname: Liu
authors.forename: Shu-Yi
authors.initials: SY
authors.lastname: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity; D016190:Carboplatin / Q000008:administration & dosage / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity; D050091:Dendrimers / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D008819:Mice, Nude; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D010984:Platinum / Q000737:chemistry*; D011859:Radiography; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D004337:Drug Carriers; D010984:Platinum; D016190:Carboplatin; D002945:Cisplatin
keywords: cancer therapy; corrodibility; dendrimers; platinum nanoclusters; tumor-inside activation