title: CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis.
abstract: The systemic inflammatory response represents the core pathogenic event of sepsis, underlying clinical manifestations and laboratory findings in patients. Numerous studies have shown that CD4+CD25+ T lymphocytes, also known as regulatory T lymphocytes (Treg), participate in the development of sepsis due to their ability to suppress the immune response. The present article discusses the role of Treg lymphocytes in sepsis based on a specific search strategy (Latin American and Caribbean Health Sciences / Literatura Latino-americana e do Caribe em Ciências da Saúde - LILACS, PubMed, and Scientific Electronic Library Online - SciELO) focusing on two main topics: the participation of Treg cells in inflammation and immunity as well as perspectives in the computational physiological investigation of sepsis.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Siqueira-Batista
authors.forename: Andréia Patrícia
authors.initials: AP
authors.lastname: Gomes
authors.forename: Sarah Fumian Milward
authors.initials: SF
authors.lastname: Azevedo
authors.forename: Rodrigo Roger
authors.initials: RR
authors.lastname: Vitorino
authors.forename: Eduardo Gomes de
authors.initials: EG
authors.lastname: Mendonça
authors.forename: Flávio Oliveira de
authors.initials: FO
authors.lastname: Sousa
authors.forename: Alcione de Paiva
authors.initials: Ade P
authors.lastname: Oliveira
authors.forename: Fábio Ribeiro
authors.initials: FR
authors.lastname: Cerqueira
authors.forename: Sérgio Oliveira de
authors.initials: SO
authors.lastname: Paula
authors.forename: Maria Goreti de Almeida
authors.initials: MG
authors.lastname: Oliveira