title: Association of single nucleotide polymorphisms in the gene encoding platelet endothelial cell adhesion molecule-1 with the risk of myocardial infarction: a systematic review and meta-analysis.
abstract: BACKGROUND
  Single nucleotide polymorphisms (SNPs) within the platelet endothelial cell adhesion molecule-1 (PECAM-1) gene have been proposed as predisposing factors for myocardial infarction (MI) but published reports have given conflicting findings.
  
  
  OBJECTIVE
  The present study aimed to clarify the association between SNPs in PECAM-1 and MI using a meta-analysis of published studies.
  
  
  METHODS
  Medline, HuGE Navigator and SCOPUS Library databases were searched to identify case-control studies which examined the association of SNPs in PECAM-1 and MI. Data were extracted using standardized methods. Combined odds ratios (OR) with 95% confidence intervals (CI) for the association of SNPs with MI were calculated using a random effect approach and under additive, dominant and recessive models of inheritance.
  
  
  RESULTS
  A total of 7 studies comprising 3886 cases and 4097 controls fulfilled the inclusion criteria. Three SNPs in PECAM-1 were investigated, namely rs668 (Leu125Val), rs12953 (Ser563Asn) and rs1131012 (Arg670Gly). The GG genotype of rs1131012 was associated with a reduced risk of MI under a recessive (OR: 0.81; 95%CI: 0.69-0.94; p=0.010), but not additive and dominant models (p>0.05). This association was robust in sensitivity analyses and not subject to heterogeneity. No significant association was detected between rs668 and rs12953 with MI under any of the inheritance models.
  
  
  CONCLUSIONS
  The results of the current meta-analysis suggest that homozygous polymorphic genotype (GG) of the rs1131012 SNP may confer protection against MI. The impact of this variant on the expression and function of PECAM-1 needs to be elucidated in future investigations.
authors.affiliation: Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.forename: Dylan R
authors.initials: DR
authors.lastname: Morris
authors.forename: Erik
authors.initials: E
authors.lastname: Biros
authors.forename: Jonathan
authors.initials: J
authors.lastname: Golledge
mesh_terms: D002448:Cell Adhesion / Q000235:genetics; D042783:Endothelial Cells / Q000473:pathology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics* / Q000473:pathology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019408:Platelet Endothelial Cell Adhesion Molecule-1
keywords: Cardiovascular disease; atherothrombosis; cell adhesion molecule; meta-analysis; systematic review