title: Prenatal bisphenol A and birth outcomes: MOCEH (Mothers and Children's Environmental Health) study.
abstract: Bisphenol A (BPA) is used primarily in the production of polycarbonate plastics and epoxy resins. Widespread exposure to BPA has created a great deal of concern regarding its potential adverse effects on human health. This study examined the relationship between prenatal BPA exposure and birth outcomes, including birth weight, birth length, and ponderal index considering gender difference. A multi-center birth cohort study, Mothers and Children's Environmental Health (MOCEH) has been established in Korea since 2006. Study subjects are 757 pregnant women from the original cohort, who had their urinary BPA level measured during the third trimester, as well as information on birth outcome, prior medical history, psychosocial status, health behavior, environmental exposure as well as socio-demographic characteristics. Regression analysis was performed to assess the effect of BPA on birth outcome. The geometric mean concentration of BPA in pregnant women was 1.29 μg/L (1.87 μg/g creatinine) during late pregnancy. Urinary BPA concentrations were shown to be higher in women with a higher income level. Univariate regression analysis revealed a significant association between BPA levels and birth weight. In adjusted analysis, the second tertile of maternal BPA exposure exhibited an increase in birth weight, relative to the first tertile (p=0.04). These relationships were more pronounced in male neonates. Also, prenatal exposure to BPA was associated with an increase of ponderal index in total, and especially female neonates. This study shows that the association of prenatal exposure to BPA with anthropometric measures, such as birth weight and birth length, differed by gender. Further study is required to more fully elaborate this relationship between prenatal BPA exposure and birth outcome.
authors.affiliation: Environmental Health Research Division, National Institute of Environmental Research, Incheon, Republic of Korea; Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Bo-Eun
authors.initials: BE
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Hyesook
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Yun-Chul
authors.initials: YC
authors.lastname: Hong
authors.affiliation: Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea.
authors.forename: Mina
authors.initials: M
authors.lastname: Ha
authors.affiliation: Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
authors.forename: Yangho
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Namsoo
authors.initials: N
authors.lastname: Chang
authors.affiliation: Division of Child & Adolescent Psychiatry, Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Boong-Nyun
authors.initials: BN
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Environmental Health Research Division, National Institute of Environmental Research, Incheon, Republic of Korea.
authors.forename: Seung-Do
authors.initials: SD
authors.lastname: Yu
authors.affiliation: Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea. Electronic address: eunheeha@ewha.ac.kr.
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Ha
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000009:adverse effects* / Q000652:urine; D001724:Birth Weight; D001827:Body Height; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000652:urine; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004782:Environmental Health; D004785:Environmental Pollutants / Q000009:adverse effects / Q000652:urine; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects* / Q000652:urine; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D009035:Mothers; D010636:Phenols / Q000009:adverse effects* / Q000652:urine; D010969:Plastics / Q000737:chemistry; D011247:Pregnancy; D011256:Pregnancy Outcome; D011297:Prenatal Exposure Delayed Effects; D012044:Regression Analysis; D056910:Republic of Korea; D012737:Sex Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D010969:Plastics; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: BMI; BPA; Birth weight; Bisphenol A; Cr; Endocrine disruptors; Fetal development; GM; LOD; MOCEH; Mothers and Children's Environmental Health; OR; Pregnancy; UGT; bisphenol A; body mass index; creatinine; geometric mean; limits of detection; odds ratio; uridine diphosphate–glucoronosyl transferase