title: Candidate gene analysis: severe intraventricular hemorrhage in inborn preterm neonates.
abstract: Intraventricular hemorrhage (IVH) is a disorder of complex etiology. We analyzed genotypes for 7 genes from 224 inborn preterm neonates treated with antenatal steroids and grade 3-4 IVH and 389 matched controls. Only methylenetetrahydrofolate reductase was more prevalent in cases of IVH, emphasizing the need for more comprehensive genetic strategies.
authors.affiliation: Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Ulrika
authors.initials: U
authors.lastname: Adén
authors.forename: Aiping
authors.initials: A
authors.lastname: Lin
authors.forename: Waldemar
authors.initials: W
authors.lastname: Carlo
authors.forename: Alan
authors.initials: A
authors.lastname: Leviton
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Murray
authors.forename: Mikko
authors.initials: M
authors.lastname: Hallman
authors.forename: Richard P
authors.initials: RP
authors.lastname: Lifton
authors.forename: Heping
authors.initials: H
authors.lastname: Zhang
authors.forename: Laura R
authors.initials: LR
authors.lastname: Ment
mesh_terms: D001724:Birth Weight; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D013256:Steroids / Q000627:therapeutic use
chemical_list: D013256:Steroids; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: AGA; Appropriate for gestational age; BW; Birth weight; COL4A1; Collagen 4A1; Gr; Grade; IL; IVH; Interleukin; Intraventricular hemorrhage; MTHFR; Methylenetetrahydrofolate reductase; TNF; Tumor necrosis factor
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