title: Prognostic value of lymphovascular space invasion in endometrial cancer.
abstract: OBJECTIVE
  To evaluate the prognostic significance of lymphovascular space invasion (LVSI) in endometrial cancer (EC) patients.
  
  
  METHODS
  A total of 73 patients who underwent surgery for endometrial cancer at the University Hospital for Tumors, Zagreb, Croatia and University Hospital Centre Split, Croatia, in the period from 1999 to 2008 were evaluated.
  
  
  RESULTS
  Lymphovascular space invasion was identified in 58 cases (79.5%). Univariate analysis and multivariate analysis demonstrated a significant association between LVSI and EC recurrence (p=0.004; HR 0.241, CI 0.114-0.511). The median time from diagnosis to EC recurrence of patients with positive LVSI was 20 months, and the median time from diagnosis to EC recurrence of patients with negative LVSI was 86 months (relative risk of recurrence 0.24).
  
  
  CONCLUSIONS
  Lymphovascular space invasion identified on routine haematoxylin and eosin stained sections, is a significant independent predictor of endometrial cancer recurrence.
authors.affiliation: 1Department of Gynecologic Oncology, Sestre Milosrdnice University Hospital Centre-University Hospital for Tumors, Zagreb, 2Department of Gastroenterology, University Hospital Centre Split, Split, 3Department of Transfusion Medicine, 4Department of Clinical Pathology, 5Department for Internistic Oncology and Chemotherapy; Sestre Milosrdnice University Hospital Centre-University Hospital for Tumors, Zagreb; Croatia.
authors.forename: Mario
authors.initials: M
authors.lastname: Puljiz
authors.forename: Željko
authors.initials: Ž
authors.lastname: Puljiz
authors.forename: Damir
authors.initials: D
authors.lastname: Danolić
authors.forename: Ilija
authors.initials: I
authors.lastname: Alvir
authors.forename: Darko
authors.initials: D
authors.lastname: Tomica
authors.forename: Ivica
authors.initials: I
authors.lastname: Mamić
authors.forename: Tiha
authors.initials: T
authors.lastname: Vučemilo
authors.forename: Melita
authors.initials: M
authors.lastname: Perić Balja
authors.forename: Robert
authors.initials: R
authors.lastname: Zorica
mesh_terms: D016889:Endometrial Neoplasms / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis