title: Facile surface modification of silicone rubber with zwitterionic polymers for improving blood compatibility.
abstract: A facile approach to modify silicone rubber (SR) membrane for improving the blood compatibility was investigated. The hydrophobic SR surface was firstly activated by air plasma, after which an initiator was immobilized on the activated surface for atom transfer radical polymerization (ATRP). Three zwitterionic polymers were then grafted from SR membrane via surface-initiated atom transfer radical polymerization (SI-ATRP). The surface composition, wettability, and morphology of the membranes before and after modification were characterized by X-ray photoelectron spectroscopy (XPS), static water contact angle (WCA) measurement, and atomic force microscopy (AFM). Results showed that zwitterionic polymers were successfully grafted from SR surfaces, which remarkably improved the wettability of the SR surface. The blood compatibility of the membranes was evaluated by protein adsorption and platelet adhesion tests in vitro. As observed, all the zwitterionic polymer modified surfaces have improved resistance to nonspecific protein adsorption and have excellent resistance to platelet adhesion, showing significantly improved blood compatibility. This work should inspire many creative uses of SR based materials for biomedical applications such as vessel, catheter, and microfluidics.
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Pingsheng
authors.initials: P
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Yuan
authors.forename: Mengzhou
authors.initials: M
authors.lastname: Chen
authors.forename: Shishan
authors.initials: S
authors.lastname: Wu
authors.forename: Sicong
authors.initials: S
authors.lastname: Lin
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000327:Adsorption / Q000187:drug effects; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D007477:Ions; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D056951:Photoelectron Spectroscopy; D010973:Platelet Adhesiveness / Q000187:drug effects; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry; D012826:Silicone Elastomers / Q000737:chemistry* / Q000494:pharmacology*; D014867:Water / Q000737:chemistry; D017155:Wettability / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D007477:Ions; D011108:Polymers; D012826:Silicone Elastomers; D014867:Water; D012825:Silicon
keywords: ATRP; Platelet adhesion; Protein adsorption; Silicone rubber; Zwitterionic polymers