title: TNF-alpha promoter region polymorphisms affect HBV virus clearance in southern Chinese.
abstract: BACKGROUND
  There are many cytokines, including TNF-α, TGFβ, PGF, and other factors contributing towards fibrogenesis, that play a role in the control of HBV infection. Among these, TNF-α is the most important cytokine in host immune response to viral infection. This study aimed to determine whether differences in the promoter region of the TNF-α gene may alter the outcomes of HBV infection.
  
  
  METHODS
  Two polymorphisms of tumor necrosis factor-α (TNF-α) gene, -308 G/A (rs1800629) and -863 C/A (rs1800630), were analyzed by DNA sequence in the case-control sample using 171 chronic HBV-infected patients and 227 recovered HBV-infected controls. All subjects were unrelated southern Han Chinese.
  
  
  RESULTS
  For TNF-α-308, healthy controls compared to HBV infection have a significantly higher allele A and GA genotype frequency. For TNF-α-863, no significant differences in allele or genotype frequencies between the case groups and the control group were observed.
  
  
  CONCLUSIONS
  This study provides evidence of a positive association between HBV clearance and TNF-α-308A.
authors.affiliation: Operating Room, The Second Hospital of Nanchang, 90 Bayidadao Road, Nanchang, JiangXi 330003, China; NPFPC Laboratory of Contraception and Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Xu
authors.forename: Sanjiao
authors.initials: S
authors.lastname: Zhang
authors.forename: Zhaofeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Lingyuan
authors.initials: L
authors.lastname: Fu
authors.forename: Qiupeng
authors.initials: Q
authors.lastname: Zheng
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Shengzhen
authors.initials: S
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Du
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006515:Hepatitis B virus / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000821:virology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Hepatitis B virus; Polymorphism; Tumor necrosis factor-α