title: A comparative study of positive rate of placental α-microglobulin-1 test in pre-term pregnant women with and without uterine contraction.
abstract: The aim of this study was to compare positive placental alpha-microglobulin-1 (PAMG-1) test rates with clinical significance of pre-term pregnant women, intact membrane with and without uterine contraction. A prospective analytic study was performed including 100 pre-term pregnant women with intact membranes. Patients were classified into two groups, patients with uterine contraction (n = 50) and patients without contraction (n = 50). Conventional standard methods were performed to exclude rupture of membranes. PAMG-1 test was performed. Positive results of the tests and clinical significance (including time from test to delivery, route of delivery and outcomes of the fetuses) were determined. PAMG-1 positive rate was 10% (5/50) and 0% in contraction group and no contraction group, respectively (p = 0.028). Gestational age at delivery and test-to-delivery interval were less in contraction group than those in no-contraction group. When compared between positive test (n = 5) and negative test (n = 45) in pre-term contraction. Test-to-delivery interval was shorter positive group (20 vs. 720 h, p = 0.025). In conclusion, in pre-term pregnant women with intact membranes, PAMG-1 test rates are more positive in cases of uterine contraction. Pre-term pregnant women in labour with a positive PAMG-1 test had a significantly shorter test-to-delivery interval than those with a negative test.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Sukchaya
authors.forename: V
authors.initials: V
authors.lastname: Phupong
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D011247:Pregnancy; D047928:Premature Birth / Q000378:metabolism*; D011446:Prospective Studies; D014590:Uterine Contraction / Q000378:metabolism*; D014626:Vaginal Smears; D055815:Young Adult
chemical_list: C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1