title: In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats.
abstract: The present study was undertaken to evaluate the in vitro antioxidant and antihyperlipidemic activity of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet-induced hyperlipidemic rats. In in vitro studies T. asiatica leaves ethyl acetate extract showed very good scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC₅₀ 605.34±2.62 μg/ml), hydroxyl (IC₅₀ 694.37±2.12 μg/ml) and nitric oxide (IC₅₀ 897.83±1.48 μg/ml) radicals, as well as high reducing power. In Triton WR-1339 induced hyperlipidemic rats, oral treatment with T. asiatica leaves ethyl acetate extract produced a significant (P≤0.005) decrease in the levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and significant increase in high-density lipoprotein cholesterol (HDL-C) in comparison with hexane and methanol extracts. In high fat diet-fed hyperlipidemic rats, the ethyl acetate extract (200 and 400 mg/kg) significantly altered the plasma and liver lipids levels to near normal.
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India.
authors.forename: Santiagu Stephen
authors.initials: SS
authors.lastname: Irudayaraj
authors.forename: Christudas
authors.initials: C
authors.lastname: Sunil
authors.forename: Veeramuthu
authors.initials: V
authors.lastname: Duraipandiyan
authors.forename: Savarimuthu
authors.initials: S
authors.lastname: Ignacimuthu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D006586:Hexanes / Q000737:chemistry; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000503:physiopathology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D027821:Rutaceae / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006586:Hexanes; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; C026385:n-hexane; D011092:Polyethylene Glycols; C016811:tyloxapol; D000432:Methanol
keywords: Antioxidant; Fenofibrate; High-fat diet; Hyperlipidemia; Toddalia asiatica; Triton WR-1339