title: Comparison between 1.5 and 3.0 Tesla magnetic resonance enterography for the assessment of disease activity and complications in ileo-colonic Crohn's disease.
abstract: BACKGROUND
  Magnetic resonance imaging (MRI) can assess disease activity and severity in Crohn's disease (CD). Three-Tesla magnetic resonance (3T) increases signal-to-noise ratio (SNR) and reduces time of image acquisition (IAT). Whether 3T increases the accuracy of MRI in CD compared to 1.5T is unknown.
  
  
  OBJECTIVE
  We aimed to compare prospectively the accuracy of 3 and 1.5T in ileo-colonic CD patients.
  
  
  METHODS
  Twenty-six patients with ileo-colonic CD underwent 1.5 and 3T MR enterography at the same time. Ileocolonoscopy was the reference standard for luminal disease. Sensitivity, specificity and accuracy of MRI in evaluating six signs of active and complicated disease (localization, thickening, enhancement, strictures, entero-enteric fistulas, and ulcers) were calculated for both techniques.
  
  
  RESULTS
  Three-Tesla resulted as sensitive, specific, and accurate as 1.5T in detecting disease location (accuracy 0.93 vs. 0.86), bowel wall thickening and enhancement (accuracy 0.92 vs. 0.80 for both parameters), strictures (accuracy 0.90 vs. 0.80) and entero-enteric fistulas (accuracy 0.92 vs. 0.92). 3T was superior to 1.5T in detecting ulcers (0.76 vs. 0.42, P < 0.05). SNR resulted higher in 3T, and IAT resulted shorter than 1.5.
  
  
  CONCLUSIONS
  We found that 3T is equally accurate as 1.5T in evaluating ileo-colonic CD. Because of superiority in detecting mucosal ulcers, 3T should be preferred in patients with ileo-colonic CD.
authors.affiliation: IBD Center, Gastroenterology, IRCCS Humanitas, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Gionata
authors.initials: G
authors.lastname: Fiorino
authors.forename: Cristiana
authors.initials: C
authors.lastname: Bonifacio
authors.forename: Mauro
authors.initials: M
authors.lastname: Padrenostro
authors.forename: Federica Mrakic
authors.initials: FM
authors.lastname: Sposta
authors.forename: Antonino
authors.initials: A
authors.lastname: Spinelli
authors.forename: Alberto
authors.initials: A
authors.lastname: Malesci
authors.forename: Luca
authors.initials: L
authors.lastname: Balzarini
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
authors.forename: Silvio
authors.initials: S
authors.lastname: Danese
mesh_terms: D000328:Adult; D000368:Aged; D003424:Crohn Disease / Q000145:classification / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D055815:Young Adult
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