title: Pulmonary arterial hypertension and pregnancy.
abstract: This is the case report of a pregnant woman who refused pregnancy termination when diagnosed with pulmonary arterial hypertension (PAH) functional class 2-3 at the 24th week of gestation and of her newborn. A pregnant woman with PAH functional class 2-3 was treated with inhaled prostacyclin analog (iloprost), oral sildenafil, oxygen, and low molecular weight heparin. She delivered at 32nd week by Cesarean section. The infant required oxygen up to 36th week postconceptional age and had a short steroid treatment. The mother needed close cardiovascular monitorization, intensive oxygen and pulmonary vasodilator therapy for 2 months and was discharged with oxygen and oral iloprost treatment. A multidisciplinary approach together with pulmonary vasodilator therapy may be succesful in such a high-risk pregnant woman.
authors.affiliation: Department of Pediatrics, Division of Neonatology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Terek
authors.forename: Meral
authors.initials: M
authors.lastname: Kayikcioglu
authors.forename: Hakan
authors.initials: H
authors.lastname: Kultursay
authors.forename: Mete
authors.initials: M
authors.lastname: Ergenoglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yalaz
authors.forename: Oktay
authors.initials: O
authors.lastname: Musayev
authors.forename: Nesrin
authors.initials: N
authors.lastname: Mogulkoc
authors.forename: Ilkben
authors.initials: I
authors.lastname: Gunusen
authors.forename: Mete
authors.initials: M
authors.lastname: Akisu
authors.forename: Nilgun
authors.initials: N
authors.lastname: Kultursay
keywords: Iloprost; newborn; pregnancy; pulmonary hypertension; sildenafil; survival; therapy
references.citation: Am J Cardiol. 1997 Dec 1;80(11):1469-73
references.pmid: 9399724
references.citation: J Am Coll Cardiol. 1998 Jun;31(7):1650-7
references.pmid: 9626847
references.citation: Am J Obstet Gynecol. 1989 Dec;161(6 Pt 1):1439-42
references.pmid: 2603895
references.citation: Eur Heart J. 2009 Oct;30(20):2493-537
references.pmid: 19713419
references.citation: Obstet Gynecol. 2005 Nov;106(5 Pt 2):1206-10
references.pmid: 16260574
references.citation: Crit Care Nurse. 2010 Apr;30(2):45-52
references.pmid: 20360450
references.citation: Int J Obstet Anesth. 2009 Apr;18(2):156-64
references.pmid: 19223169
references.citation: Surg Clin North Am. 2008 Apr;88(2):391-401, vii
references.pmid: 18381119
references.citation: Intern Med J. 2009 Nov;39(11):766-70
references.pmid: 19912403
references.citation: Anesthesiology. 2005 Jun;102(6):1133-7; discussion 5A-6A
references.pmid: 15915025
references.citation: Eur Respir J. 2005 Jul;26(1):168-73
references.pmid: 15994404
references.citation: Eur Respir J. 2007 Dec;30(6):1103-10
references.pmid: 17804449
references.citation: Chest. 2004 Sep;126(3 Suppl):627S-644S
references.pmid: 15383488
references.citation: Am J Health Syst Pharm. 2007 Sep 15;64(18):1922-6
references.pmid: 17823103
references.citation: BJOG. 2010 Apr;117(5):565-74
references.pmid: 20374595
references.citation: Chest. 2001 Mar;119(3):973-5
references.pmid: 11243988
references.citation: Int J Cardiol. 2004 Dec;97 Suppl 1:11-3
references.pmid: 15590074
references.citation: Circulation. 2009 Apr 28;119(16):2250-94
references.pmid: 19332472
references.citation: J Am Coll Cardiol. 2008 Apr 22;51(16):1527-38
references.pmid: 18420094
references.citation: Vascul Pharmacol. 2007 Aug-Sep;47(2-3):184-8
references.pmid: 17627899