title: An in vivo study of osteoplastic properties of resorbable poly-3-hydroxybutyrate in models of segmental osteotomy and chronic osteomyelitis.
abstract: A series of 3D implants and filling materials prepared from powdered biodegradable polymers, polyhydroxyalkanoates (PHAs), have been designed for the purposes of reparative osteogenesis. The 3D implants are made of resorbable polymer of hydroxybutyric acid (poly-3-hydroxybutyrate, P3HB) and a composite of this polymer with hydroxyapatite (HA) (P3HB/HA). The properties of the implants were studied in vivo in a model of segmental osteotomy and compared with commercial material Bio-Oss(®). All implants containing P3HB as the main component facilitate reconstructive osteogenesis. P3HB and P3HB/HA show pronounced osteoplastic properties; their in vivo degradation is slow and corresponds to the growth of a new bone tissue, facilitating normal reparative osteogenesis. Also, powdered P3HB and P3HB/tienam can be used as filling materials for osteoplasty of bone cavities infected by Staphylococcus aureus. Biodegradable 3D implants and P3HB-based filling materials show pronounced osteoplastic properties and degrade in vivo at a slow rate, enabling normal reparative osteogenesis.
authors.affiliation: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , Akademgorodok, Krasnoyarsk , Russia.
authors.forename: Ekaterina I
authors.initials: EI
authors.lastname: Shishatskaya
authors.forename: Igor V
authors.initials: IV
authors.lastname: Kamendov
authors.forename: Sergey I
authors.initials: SI
authors.lastname: Starosvetsky
authors.forename: Yuri S
authors.initials: YS
authors.lastname: Vinnik
authors.forename: Nadya N
authors.initials: NN
authors.lastname: Markelova
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Shageev
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Khorzhevsky
authors.forename: Olga V
authors.initials: OV
authors.lastname: Peryanova
authors.forename: Anna A
authors.initials: AA
authors.lastname: Shumilova
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism* / Q000494:pharmacology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D006885:Hydroxybutyrates / Q000378:metabolism* / Q000494:pharmacology*; D010012:Osteogenesis / Q000187:drug effects; D010019:Osteomyelitis / Q000382:microbiology / Q000503:physiopathology*; D010027:Osteotomy; D011091:Polyesters / Q000378:metabolism* / Q000494:pharmacology*; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000502:physiology; D000094122:Polyhydroxybutyrates
chemical_list: D001672:Biocompatible Materials; D006885:Hydroxybutyrates; D011091:Polyesters; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates
keywords: 3D implants; P3HB; bone substitute; histological analysis and radiography; hydroxyapatite; polymer of 3-hydroxybutyric acid; reconstructive osteogenesis