title: Peripartum cardiomyopathy: moving towards a more central role of genetics.
abstract: Peripartum cardiomyopathy (PCM) is a relatively rare disease with potentially devasting consequences requiring prompt identification and correct treatment. Overall prognosis is good in majority of the cases, although some patients may progress to irreversible heart failure. Early diagnosis is important and effective treatment reduces mortality rates and increases the chance of complete recovery of ventricular systolic function. The aetiology and pathogenesis seems to be multifactorial and poorly understood, with the available literature rather conflicting. In recent years, there has been increased interest in the role played by genetic predisposition in the development of PCM. It probably develops as a result of a complex interaction of pregnancy-associated factors and genetic factors and recently there have been many observations pointing out the central role played by a genetic predisposition. The direct and indirect observations on genetic susceptibility may offer new insights into the pathogenesis of PCM. However, larger studies are needed before advising routine genetic testing in these patients.
authors.affiliation: Department of Cardiology, San Maurizio Regional Hospital of Bolzano, Italy. roberto.cemin@asbz.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Cemin
authors.forename: Rajesh
authors.initials: R
authors.lastname: Janardhanan
authors.forename: Luca
authors.initials: L
authors.lastname: Donazzan
authors.forename: Massimo
authors.initials: M
authors.lastname: Daves
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001971:Bromocriptine / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics*; D004452:Echocardiography; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000235:genetics / Q000517:prevention & control; D006801:Humans; D058725:Peripartum Period; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000000981:diagnostic imaging / Q000209:etiology / Q000235:genetics*; D059285:Pregnancy, Twin / Q000276:immunology; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001971:Bromocriptine
references.citation: Lancet. 2000 Sep 9;356(9233):930-3
references.pmid: 11036910
references.citation: Am J Obstet Gynecol. 2008 Oct;199(4):e5-6
references.pmid: 18928969
references.citation: J Med Case Rep. 2010 Mar 04;4:80
references.pmid: 20202212
references.citation: Circulation. 2005 Apr 26;111(16):2050-5
references.pmid: 15851613
references.citation: J Am Coll Cardiol. 2000 Mar 1;35(3):701-5
references.pmid: 10716473
references.citation: Am Heart J. 2006 Sep;152(3):509-13
references.pmid: 16923422
references.citation: J Am Coll Cardiol. 2007 Dec 11;50(24):2354-5
references.pmid: 18068047
references.citation: N Engl J Med. 1982 Sep 16;307(12):731-4
references.pmid: 7110225
references.citation: Mayo Clin Proc. 2005 Dec;80(12):1602-6
references.pmid: 16342653
references.citation: Int J Cardiol. 1997 Jun 27;60(1):111-4
references.pmid: 9209949
references.citation: Circulation. 2010 May 25;121(20):2169-75
references.pmid: 20458010
references.citation: Am J Obstet Gynecol. 2002 May;186(5):1005-10
references.pmid: 12015528
references.citation: Circulation. 1971 Nov;44(5):964-8
references.pmid: 4255967
references.citation: Am J Cardiol. 1994 Sep 1;74(5):474-7
references.pmid: 8059728
references.citation: Minerva Cardioangiol. 2006 Jun;54(3):331-6
references.pmid: 16733507
references.citation: J Am Coll Cardiol. 2008 May 27;51(21):2083; author reply 2083-4
references.pmid: 18498970
references.citation: Am J Cardiol. 2007 Jul 15;100(2):302-4
references.pmid: 17631087
references.citation: Circulation. 2010 Apr 6;121(13):1465-73
references.pmid: 20308616
references.citation: Anesth Analg. 2004 Mar;98(3):822-4, table of contents
references.pmid: 14980944
references.citation: J Am Coll Cardiol. 2010 Feb 16;55(7):654-9
references.pmid: 20170791
references.citation: J Am Coll Cardiol. 1986 Jul;8(1):52-6
references.pmid: 3711532
references.citation: Int J Cardiol. 2007 Jun 12;118(3):295-303
references.pmid: 17208320
references.citation: J Am Coll Cardiol. 2007 Aug 21;50(8):727-37
references.pmid: 17707176
references.citation: J Cardiovasc Transl Res. 2008 Jun;1(2):137-43
references.pmid: 20559908
references.citation: Minerva Cardioangiol. 2003 Feb;51(1):41-8
references.pmid: 12652259
references.citation: Lancet. 2006 Aug 19;368(9536):687-93
references.pmid: 16920474
references.citation: Circulation. 2005 Sep 27;112(13):1965-70
references.pmid: 16172268
references.citation: Heart. 2011 Dec;97(23):1970-81
references.pmid: 22058286
references.citation: Hum Reprod. 2005 Sep;20(9):2666-8
references.pmid: 16093265
references.citation: Circulation. 2010 May 25;121(20):2176-82
references.pmid: 20458009
references.citation: Br J Anaesth. 2004 Sep;93(3):428-39
references.pmid: 15194627
references.citation: Circ Cardiovasc Genet. 2011 Aug 1;4(4):359-66
references.pmid: 21665988
references.citation: Am Heart J. 2005 Aug;150(2):263-9
references.pmid: 16086928
references.citation: Obstet Gynecol. 2005 Jun;105(6):1303-8
references.pmid: 15932821
references.citation: Br Heart J. 1986 Sep;56(3):285-91
references.pmid: 3756045
references.citation: Int J Cardiol. 2002 Dec;86(2-3):311-6
references.pmid: 12419571
references.citation: N Engl J Med. 2001 May 24;344(21):1567-71
references.pmid: 11372007
references.citation: Obstet Gynecol. 1999 Aug;94(2):311-6
references.pmid: 10432149
references.citation: Eur Heart J. 2006 Feb;27(4):441-6
references.pmid: 16143707
references.citation: Int J Gynaecol Obstet. 2006 Nov;95(2):104-9
references.pmid: 16935289
references.citation: J Am Soc Echocardiogr. 2005 Jan;18(1):45-8
references.pmid: 15637488
references.citation: Eur J Heart Fail. 2008 Nov;10(11):1149-51
references.pmid: 18926768
references.citation: Eur J Heart Fail. 2010 Aug;12(8):767-78
references.pmid: 20675664
references.citation: Ann Thorac Surg. 2007 Jul;84(1):262-4
references.pmid: 17588427
references.citation: Cell. 2007 Feb 9;128(3):589-600
references.pmid: 17289576
references.citation: Am J Med Genet. 2000 Mar 6;91(1):22-8
references.pmid: 10751084
references.citation: Clin Rev Allergy Immunol. 2002 Dec;23(3):301-24
references.pmid: 12402414
references.citation: Curr Cardiol Rev. 2009 Nov;5(4):268-72
references.pmid: 21037843
references.citation: Arch Intern Med. 1963 May;111:651-5
references.pmid: 13943404
references.citation: N Engl J Med. 2000 Apr 13;342(15):1077-84
references.pmid: 10760308
references.citation: JAMA. 2000 Mar 1;283(9):1183-8
references.pmid: 10703781
references.citation: Circulation. 2010 May 25;121(20):2157-9
references.pmid: 20458008