title: Semisynthesis and quantitative structure-activity relationship (QSAR) study of some cholesterol-based hydrazone derivatives as insecticidal agents.
abstract: In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, four series of novel cholesterol-based hydrazone derivatives were synthesized, and their insecticidal activity was tested against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1mg/mL. All the derivatives showed the better insecticidal activity than their precursor cholesterol. Quantitative structure-activity relationship (QSAR) model demonstrated that six descriptors such as RDF085v, Mor06u, Mor11u, Dv, HATS0v and H-046, are likely to influence the insecticidal activity of these compounds. Among them, two important ones are the Mor06u and RDF085v.
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Shao
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhi
authors.forename: Qu
authors.initials: Q
authors.lastname: Huan
authors.forename: Xiang
authors.initials: X
authors.lastname: Yu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Yao
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D002784:Cholesterol / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D008958:Models, Molecular; D009036:Moths / Q000187:drug effects* / Q000254:growth & development; D021281:Quantitative Structure-Activity Relationship
chemical_list: D001688:Biological Products; D006835:Hydrazones; D007306:Insecticides; D002784:Cholesterol
keywords: Botanical insecticide; Cholesterol; Insecticidal activity; Mythimna separata (Walker); QSAR; Structural modification