title: [Ways to personalized medicine for gastric cancer].
abstract: Gastric cancer is the fourth most common tumor and the second most common cause of cancer-related deaths in the world. Approximately 70 % of the patients already have lymph node metastases at the time of the diagnosis leading to a median overall survival time of 16.7 months. Complete resection of the primary tumor with D2 lymphadenectomy offers the only chance of cure in the early stages of the disease. Survival of more locally advanced gastric cancer was improved by the introduction of perioperative, adjuvant and palliative chemotherapy of gastric cancer; however, the identification of novel predictive and diagnostic targets is urgently needed. Our own studies on gastric cancer biology identified several putative tumor biologically relevant G-protein-coupled receptors (e.g. AT1R, AT2R, CXCR4, FZD7, LGR4, LGR5, LGR6). Some of these receptors are also putative stem cell markers and may serve as future targets of an individualized therapy of gastric cancer.
authors.affiliation: Institut für Pathologie, Christian-Albrechts-Universität Kiel, Arnold-Heller-Strasse 3/14, Kiel, Germany. christoph.roecken@uk-sh.de
authors.forename: C
authors.initials: C
authors.lastname: Röcken
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D009367:Neoplasm Staging; D010166:Palliative Care; D057285:Precision Medicine; D011379:Prognosis; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D043562:Receptors, G-Protein-Coupled
references.citation: Lancet. 2010 Aug 28;376(9742):687-97
references.pmid: 20728210
references.citation: Crit Rev Oncol Hematol. 2011 May;78(2):112-26
references.pmid: 20570171
references.citation: Ann Oncol. 2013 Mar;24(3):725-33
references.pmid: 23139264
references.citation: Cancer. 2010 Dec 15;116(24):5592-8
references.pmid: 20737569
references.citation: Genome Biol. 2003;4(8):225
references.pmid: 12914653
references.citation: Lancet Oncol. 2013 May;14(6):490-9
references.pmid: 23594786
references.citation: Virchows Arch. 2010 Sep;457(3):299-307
references.pmid: 20665045
references.citation: Int J Biochem Cell Biol. 2003 Jun;35(6):881-900
references.pmid: 12676174
references.citation: Ann Surg. 2012 Mar;255(3):486-91
references.pmid: 22167003
references.citation: Science. 2004 Nov 26;306(5701):1568-71
references.pmid: 15567866
references.citation: Gastroenterology. 2011 Aug;141(2):476-85, 485.e1-11
references.pmid: 21684283
references.citation: Ann Surg Oncol. 2011 Jul;18(7):1869-76
references.pmid: 21246404
references.citation: Cancer. 2003 Oct 1;98(7):1521-30
references.pmid: 14508841
references.citation: Int J Cancer. 2012 Jun 15;130(12):2845-56
references.pmid: 21780108
references.citation: Virchows Arch. 2012 Jan;460(1):3-8
references.pmid: 22143935
references.citation: Nat Rev Mol Cell Biol. 2002 Sep;3(9):639-50
references.pmid: 12209124
references.citation: Blood Press. 2003;12(2):70-88
references.pmid: 12797627
references.citation: Int J Oncol. 2004 Nov;25(5):1223-32
references.pmid: 15492809
references.citation: Oncology. 2012;83(6):354-60
references.pmid: 23052034
references.citation: Ann Surg. 2011 May;253(5):934-9
references.pmid: 21490451
references.citation: Lancet Oncol. 2013 May;14(6):440-2
references.pmid: 23594785
references.citation: Ann Surg Oncol. 2012 Jun;19(6):1918-27
references.pmid: 22246426
references.citation: Semin Cancer Biol. 2012 Oct;22(5-6):396-403
references.pmid: 22554795
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1206-12
references.pmid: 17548686
references.citation: Br J Cancer. 2012 Jul 10;107(2):325-33
references.pmid: 22644302
references.citation: PLoS One. 2012;7(4):e35486
references.pmid: 22530031
references.citation: Ann Surg. 2012 Dec;256(6):1002-7
references.pmid: 22968067
references.citation: Am J Pathol. 2011 Apr;178(4):1792-804
references.pmid: 21435459
references.citation: Acta Pathol Microbiol Scand. 1965;64:31-49
references.pmid: 14320675
references.citation: Nat Rev Cancer. 2007 Feb;7(2):79-94
references.pmid: 17251915
references.citation: J Gastric Cancer. 2011 Jun;11(2):94-100
references.pmid: 22076209
references.citation: Z Gastroenterol. 2008 Aug;46(8):799-840
references.pmid: 18759205
references.citation: Nat Genet. 2012 May;44(5):570-4
references.pmid: 22484628
references.citation: Front Biosci (Schol Ed). 2012 Jan 01;4:269-76
references.pmid: 22202059
references.citation: Gut. 2012 May;61(5):673-84
references.pmid: 22315472
references.citation: Pathol Annu. 1972;7:349-415
references.pmid: 4557936
references.citation: Eur J Cancer. 2013 Jan;49(1):219-30
references.pmid: 22683307
references.citation: Clin Cancer Res. 2005 Apr 1;11(7):2526-30
references.pmid: 15814629
references.citation: Br J Pharmacol. 2008 Mar;153 Suppl 1:S339-46
references.pmid: 18071299
references.citation: Histol Histopathol. 2006 Dec;21(12):1339-53
references.pmid: 16977585
references.citation: Gastroenterology. 2012 Feb;142(2):281-91
references.pmid: 22062361
references.citation: J Cancer. 2012;3:137-44
references.pmid: 22481979
references.citation: Virchows Arch. 2012 Oct;461(4):355-65
references.pmid: 22855134
references.citation: Z Gastroenterol. 2011 Apr;49(4):461-531
references.pmid: 21476183
references.citation: J Clin Oncol. 2013 Jan 10;31(2):263-71
references.pmid: 23213098
references.citation: Gan. 1968 Jun;59(3):251-8
references.pmid: 5726267
references.citation: Diagn Mol Pathol. 2013 Sep;22(3):127-37
references.pmid: 23846438
references.citation: Gut. 1992 May;33(5):606-12
references.pmid: 1377153
references.citation: Pharmacol Rev. 2000 Sep;52(3):415-72
references.pmid: 10977869
references.citation: N Engl J Med. 2006 Jul 6;355(1):11-20
references.pmid: 16822992
references.citation: PLoS One. 2010 Apr 08;5(4):e10087
references.pmid: 20386750
references.citation: J Clin Oncol. 2011 Jun 10;29(17):2364-71
references.pmid: 21537040
references.citation: Cancer. 1977 Jun;39(6):2475-85
references.pmid: 872047
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2987-9
references.pmid: 16365022
references.citation: World J Surg. 2011 Dec;35(12):2723-9
references.pmid: 21918892
references.citation: Gastroenterology. 2010 May;138(5):1681-96
references.pmid: 20417836