title: Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste.
abstract: Electronic waste recycling produces Polycyclic Aromatic Hydrocarbons (PAHs) and Polybrominated Diphenyl Ethers (PBDEs) which may affect fetal growth and development by altering the insulin-like-growth factor (IGF) system. Questionnaires were administered to pregnant women (Guiyu, an e-waste site, n = 101; control, n = 53), and umbilical cord blood (UCB) and placentas were collected upon delivery. PBDEs and PAHs in UCB and placental IGF-1 and IGFBP-3 mRNA levels were analyzed using GC-MS and real-time PCR, respectively. Infant birth length and Apgar scores were lower in Guiyu. All PAHs (except Fl, Chr, IP, BbF and BP), total 16-PAHs, total/individual PBDEs, placental IGF-1 (median 0.23 vs 0.19; P < 0.05) and IGFBP-3 (median 1.91 vs 0.68; P < 0.001) levels were significantly higher in Guiyu. Spearman correlation showed that BDE-154, BDE-209 and ∑5ring-PAHs positively correlate with IGF-1 while PBDEs, 4 rings and total PAHs correlate with IGFBP-3 expression. Increased placental IGF-1 level might indirectly affect fetal growth and development.
authors.affiliation: Analytical Cytology Laboratory, Shantou University Medical College, 22 Xinling Rd., Shantou 515041, Guangdong, China; Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, China; Department of Cell Biology and Genetics, Shantou University Medical College, Shantou 515041, China.
authors.forename: Xijin
authors.initials: X
authors.lastname: Xu
authors.forename: Taofeek Akangbe
authors.initials: TA
authors.lastname: Yekeen
authors.forename: Qiongna
authors.initials: Q
authors.lastname: Xiao
authors.forename: Yuangping
authors.initials: Y
authors.lastname: Wang
authors.forename: Fangfang
authors.initials: F
authors.lastname: Lu
authors.forename: Xia
authors.initials: X
authors.lastname: Huo
mesh_terms: D000328:Adult; D059029:Electronic Waste; D004784:Environmental Monitoring / Q000379:methods; D004785:Environmental Pollutants / Q000097:blood* / Q000633:toxicity; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D055768:Halogenated Diphenyl Ethers / Q000097:blood* / Q000633:toxicity; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D018811:Maternal Exposure; D010920:Placenta / Q000378:metabolism; D011084:Polycyclic Aromatic Hydrocarbons / Q000097:blood* / Q000633:toxicity; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D018972:Insulin-Like Growth Factor Binding Protein 3; D011084:Polycyclic Aromatic Hydrocarbons; D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I
keywords: E-waste; Fetus; Gestation; Growth; Prenatal