title: Immunotherapy of HPV-associated head and neck cancer: Critical parameters.
abstract: Various arguments support the development of a vaccine targeting human papillomavirus (HPV) for the treatment of HPV-associated head and neck cancer. However, the mucosal localization of this tumor, the HPV-driven downregulation of MHC Class I molecules and various other immunosuppressive mechanisms must be carefully considered to improve the clinical efficacy of such an immunotherapeutic strategy.
authors.affiliation: INSERM U970 PARCC; Université Paris Descartes; Paris, France.
authors.forename: Mevyn
authors.initials: M
authors.lastname: Nizard
authors.forename: Federico
authors.initials: F
authors.lastname: Sandoval
authors.forename: Cecile
authors.initials: C
authors.lastname: Badoual
authors.forename: Helene
authors.initials: H
authors.lastname: Pere
authors.forename: Magali
authors.initials: M
authors.lastname: Terme
authors.forename: Stephane
authors.initials: S
authors.lastname: Hans
authors.forename: Nadine
authors.initials: N
authors.lastname: Benhamouda
authors.forename: Clemence
authors.initials: C
authors.lastname: Granier
authors.forename: Daniel
authors.initials: D
authors.lastname: Brasnu
authors.forename: Eric
authors.initials: E
authors.lastname: Tartour
keywords: HPV; PD1; head and neck; immunotherapy; mucosal immunity
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