title: Localized cortical thinning in patients with obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  To investigate differences in cortical thickness in patients with obstructive sleep apnea (OSA) syndrome and healthy controls.
  
  
  METHODS
  Cortical thickness was measured using a three-dimensional surface-based method that enabled more accurate measurement in deep sulci and localized regional mapping.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Thirty-eight male patients with severe OSA (mean apnea-hypopnea index > 30/h) and 36 age-matched male healthy controls were enrolled.
  
  
  METHODS
  Cortical thickness was obtained at 81,924 vertices across the entire brain by reconstructing inner and outer cortical surfaces using an automated anatomical pipeline.
  
  
  METHODS
  Group difference in cortical thickness and correlation between patients' data and thickness were analyzed by a general linear model.
  
  
  RESULTS
  Localized cortical thinning in patients was found in the orbitorectal gyri, dorsolateral/ventromedial prefrontal regions, pericentral gyri, anterior cingulate, insula, inferior parietal lobule, uncus, and basolateral temporal regions at corrected P < 0.05. Patients with OSA showed impaired attention and learning difficulty in memory tests compared to healthy controls. Higher number of respiratory arousals was related to cortical thinning of the anterior cingulate and inferior parietal lobule. A significant correlation was observed between the longer apnea maximum duration and the cortical thinning of the dorsolateral prefrontal regions, pericentral gyri, and insula. Retention scores in visual memory tests were associated with cortical thickness of parahippocampal gyrus and uncus.
  
  
  CONCLUSIONS
  Brain regions with cortical thinning may provide elucidations for prefrontal cognitive dysfunction, upper airway sensorimotor dysregulation, and cardiovascular disturbances in OSA patients, that experience sleep disruption including sleep fragmentation and oxygen desaturation.
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute (SBRI), Seoul, Korea.
authors.forename: Eun Yeon
authors.initials: EY
authors.lastname: Joo
authors.forename: Seun
authors.initials: S
authors.lastname: Jeon
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Seung Bong
authors.initials: SB
authors.lastname: Hong
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D009483:Neuropsychological Tests; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D055815:Young Adult
keywords: Brain; MRI; cortical thickness; obstructive sleep apnea
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