title: Correlation between dysplastic lineage and type of cytopenia in myelodysplastic syndromes patients with refractory anemia according to the FAB classification.
abstract: OBJECTIVE
  To analyze the correlation between dysplastic lineage and type of cytopenia in myelodysplastic syndromes.
  
  
  METHODS
  We analyzed the correlation between dysplasia and cell count using the data set of our previous morphologic study.
  
  
  RESULTS
  There were no correlations between dysgranulopoiesis of 10% or more and absolute neutrophil count (ANC). Similarly, hyposegmented mature neutrophils (Pelger) of 10% or more were not related to ANC. Interestingly, the platelet count of patients with dysmegakaryopoiesis (dys Mgk) was higher than that of patients without dys Mgk (dys Mgk ≥10% vs <10%, P = .08; dys Mgk ≥40% vs <40%, P = .02; micromegakaryocytes ≥10% vs <10%, P = .004).
  
  
  CONCLUSIONS
  Since low cell counts did not correlate with the presence of dysplastic features, we suggest that dysplastic features do not directly relate to apoptosis.
authors.affiliation: Department of Hemato-Oncology, Saitama International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan. amatsu@saitama-med.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
authors.forename: Itsuro
authors.initials: I
authors.lastname: Jinnai
authors.forename: Masako
authors.initials: M
authors.lastname: Iwanaga
authors.forename: Daisuke
authors.initials: D
authors.lastname: Okamura
authors.forename: Maho
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Tomoya
authors.initials: T
authors.lastname: Maeda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hata
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kawai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Masami
authors.initials: M
authors.lastname: Bessho
authors.forename: Masao
authors.initials: M
authors.lastname: Tomonaga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000150:complications / Q000473:pathology*; D001772:Blood Cell Count; D019070:Cell Lineage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000473:pathology*; D010198:Pancytopenia / Q000150:complications / Q000473:pathology*
keywords: Cytopenia; Dysplastic features; Myelodysplastic syndromes; WHO classification