title: Successful treatment of bilateral Paecilomyces pyelonephritis in a German shepherd dog.
abstract: A six-year-old female entire German shepherd dog was investigated for polyuria, polydipsia and lethargy. Investigations revealed a mild azotaemia and abdominal ultrasound revealed marked bilateral dilation of the renal pelves with echogenic material and proximal left hydroureter. Urine cytological examination and aspirates from the right renal pelvis revealed mats of fungal hyphae consistent with fungal bezoar formation. Fungal cultures revealed a profuse growth of Paecilomyces variotii. Initial treatment with oral itraconazole was unsuccessful, leading to bilateral nephrotomies to remove the fungal material. Postoperatively the Paecilomyces infection persisted despite continued itraconazole therapy. Treatment was commenced with amphotericin B, leading to resolution of the dog's clinical signs. To the authors' knowledge this is the first report of canine Paecilomyces pyelonephritis, without disseminated systemic disease, which documents its successful treatment.
authors.affiliation: Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Suffolk, CB8 0UH.
authors.forename: S W
authors.initials: SW
authors.lastname: Tappin
authors.forename: I
authors.initials: I
authors.lastname: Ferrandis
authors.forename: S
authors.initials: S
authors.lastname: Jakovljevic
authors.forename: E
authors.initials: E
authors.lastname: Villiers
authors.forename: R A S
authors.initials: RA
authors.lastname: White
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D017964:Itraconazole / Q000627:therapeutic use; D007668:Kidney / Q000382:microbiology / Q000601:surgery; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000662:veterinary*; D010143:Paecilomyces; D011704:Pyelonephritis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000662:veterinary*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B