title: Adipose tissue-derived stem cells in stroke treatment: from bench to bedside.
abstract: More recently, growing interests have brought cell therapy to the forefront of promising new approaches towards efficacious treatment for stroke. Of all cell-types, adipose tissue-derived mesenchymal stem cells (AD-MSC) are considered good candidates for stroke treatment because of their abundance and easy harvesting without invasive surgery from healthy donors. A wide number of experimental studies have demonstrated the potential of AD-MSC administration for improving functional deficits and have led to the first clinical trials in stroke patients. Trophic factor release and paracrine interactions, transdifferentiation potential, and immunomodulatory effects have all been cited as the main functional mechanisms involved in AD-MSC therapy. These properties make AD-MSC therapy of special interest in fomenting the enhancement of natural brain repair mechanisms such as neurogenesis, gliagenesis, oligodendrogenesis, axonal sprouting, nerve repair, and angiogenesis. This review will focus on studies showing promising results of AD-MSC in stroke treatment.
authors.affiliation: Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Centre, La Paz University Hospital, Neuroscience Area of IdiPAZ, Autonoma University of Madrid, Madrid 28046, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Gutiérrez-Fernández
authors.forename: Berta
authors.initials: B
authors.lastname: Rodríguez-Frutos
authors.forename: Laura
authors.initials: L
authors.lastname: Otero-Ortega
authors.forename: Jaime
authors.initials: J
authors.lastname: Ramos-Cejudo
authors.forename: Blanca
authors.initials: B
authors.lastname: Fuentes
authors.forename: Exuperio
authors.initials: E
authors.lastname: Díez-Tejedor
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D001921:Brain / Q000473:pathology*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D055495:Neurogenesis; D020521:Stroke / Q000628:therapy*; D016896:Treatment Outcome