title: Abdominal adiposity is associated with high-density lipoprotein subclasses in Japanese schoolchildren.
abstract: BACKGROUND
  The large HDL subclass is considered to possess cardioprotective properties. The purpose of this study is to determine the relationship among abdominal adiposity, insulin resistance and HDL subclass profiles of Japanese schoolchildren.
  
  
  METHODS
  The study subjects included 164 children (79 boys and 85 girls). We obtained waist to height ratio (WHtR), lipid profile, and HOMA-IR. The HDL subclass profile was analyzed by HPLC.
  
  
  RESULTS
  Children of either sex with abdominal obesity (WHtR≥0.5) had reduced concentrations of very large, large, and medium HDLC in conjunction with elevated triglyceride (TG) concentrations and HOMA-IR. WHtR was inversely related to the concentrations of very large (boys: r=-0.5306, p<0.0001; girls: r=-0.3483, p=0.0011), large (r=-0.6168, p<0.0001; r=-0.4387, p<0.0001), and medium (r=-0.4170, p=0.0001; r=-0.4116, p<0.0001) HDLC. The multiple regression analyses revealed that WHtR was an independent factor of the concentrations of very large, large, small, and very small HDLC in boys and the concentrations of large and medium HDLC in girls.
  
  
  CONCLUSIONS
  In Japanese schoolchildren, abdominal obesity is associated with atherogenic HDL subclass profile. Abdominal obesity may be an important target for the prevention and management of HDL subclass alteration, even in children who do not suffer from insulin resistance or hypertriglyceridemia.
authors.affiliation: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1 Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Okuma
authors.forename: Tomoo
authors.initials: T
authors.lastname: Okada
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Abe
authors.forename: Emiko
authors.initials: E
authors.lastname: Saito
authors.forename: Fujihiko
authors.initials: F
authors.lastname: Iwata
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Hara
authors.forename: Mamoru
authors.initials: M
authors.lastname: Ayusawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Mugishima
authors.forename: Shori
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism; D050154:Adiposity; D000293:Adolescent; D000367:Age Factors; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood* / Q000145:classification; D008297:Male; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008075:Lipoproteins, HDL; D014280:Triglycerides
keywords: HDL subclass; Japanese schoolchildren; Waist to height ratio