title: Interleukin-17 and acute coronary syndrome.
abstract: Inflammation plays an important role in atherosclerosis, which is also crucial for acute coronary syndrome (ACS). Recent studies have revealed that interleukin (IL)-17, which was regarded as a pro-inflammatory cytokine, has a dual function in the progress of ACS. In this review, we sum up both experimental and clinical studies on the relevance of IL-17 to atherosclerosis and its complications, and summarize the research progress on the effect of IL-17 on the atherosclerotic plaque stability and ACS onset. Although the studies are controversial and the mechanism remains unclear, we highlight the knowledge of the role of IL-17 in ACS and elucidate its potential mechanism.
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Sheng-an
authors.initials: SA
authors.lastname: Su
authors.forename: Hong
authors.initials: H
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: Mei-xiang
authors.initials: MX
authors.lastname: Xiang
authors.forename: Jian-an
authors.initials: JA
authors.lastname: Wang
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology* / Q000276:immunology*; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism*; D051379:Mice; D009203:Myocardial Infarction / Q000209:etiology / Q000276:immunology; D058226:Plaque, Atherosclerotic / Q000209:etiology / Q000276:immunology
chemical_list: D018836:Inflammation Mediators; D020381:Interleukin-17
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