title: Transmitting senescence to the cell neighbourhood.
abstract: Senescence, a cell-autonomous tumour suppressor mechanism, also has pro-tumorigenic effects on neighbouring pre-malignant cells through the senescence-associated secretory phenotype (SASP). The SASP is now shown to be regulated by inflammasomes and to induce paracrine senescence in healthy cells, indicating that senescence may also represent a non-cell-autonomous tumour suppressor mechanism linked to innate immunity.
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Hoare
authors.forename: Masashi
authors.initials: M
authors.lastname: Narita
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism*
chemical_list: D058847:Inflammasomes
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