title: Sclerosing peritonitis, a rare complication after intestinal transplant. Report of one case successfully treated with adjustment of immunosuppression.
abstract: Sclerosing peritonitis is a complication described in different clinical situations, such as patients that underwent prolonged peritoneal dialysis or renal transplantation with previous history of peritoneal dialysis. The origin of this entity is unclear so far and it is believed that several mechanisms may contribute to its development. The hallmark of sclerosing peritonitis is the continuous accumulation of fibrocollagenous deposits in the intestinal wall and mesenteries causing progressive adhesion of the intestinal loops and mesenteric retraction resulting in intestinal obstruction. Also, it has been described as a rare complication after intestinal transplant that might lead to graft failure. In this report, we describe a case of sclerosing peritonitis after intestinal transplantation that was successfully treated with modifications in the immunosuppressive regime allowing restitution of gastrointestinal transit and intestinal autonomy.
authors.affiliation: Instituto de Trasplante Multiorgánico (ITMO), Hospital Universitario Fundación Favaloro, Buenos Aires, Argentina. crumbo@ffavaloro.org
authors.forename: Carolina
authors.initials: C
authors.lastname: Rumbo
authors.forename: Agustina
authors.initials: A
authors.lastname: Zambernardi
authors.forename: Ana
authors.initials: A
authors.lastname: Cabanne
authors.forename: Martin
authors.initials: M
authors.lastname: Rumbo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Gondolesi
mesh_terms: D001706:Biopsy; D002648:Child; D006627:Hirschsprung Disease / Q000628:therapy; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007415:Intestinal Obstruction / Q000175:diagnosis / Q000209:etiology; D007422:Intestines / Q000637:transplantation*; D008297:Male; D010538:Peritonitis / Q000175:diagnosis / Q000209:etiology*; D011183:Postoperative Complications; D012598:Sclerosis / Q000175:diagnosis / Q000209:etiology*; D014180:Transplantation / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D007073:Immunoglobulin E
keywords: fibrosis; rejection; sclerosing peritonitis; small bowel; transplant