title: Risk potentiality of frontline radiotherapy associated cataract in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma.
abstract: OBJECTIVE
  To elucidate risk potentiality of frontline radiotherapy associated cataracts in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML).
  
  
  METHODS
  Data from eight consecutive patients of 41 total OAML patients who had undergone cataract surgery after frontline radiotherapy were analyzed.
  
  
  RESULTS
  The median patient age was 46 years (range, 36 to 69 years). The median total radiation dose was 3,780 cGy (range, 3,060 to 4,500 cGy), and the mean duration from radiation irradiation to cataract surgery was 36.60 ± 8.93 months. Preoperative lens opacification was primarily at the posterior lens subcapsule, and best-corrected visual acuity (BCVA) was 0.43 ± 0.21. Patients underwent the phacoemulsification surgical procedure with posterior chamber intraocular lens insertion. The average BCVA improved to 0.90 ± 0.14 after cataract surgery. Two patients underwent posterior continuous curvilinear capsulorhexis, and one had posterior capsule rupture. For posterior capsule opacification (PCO), three patients received Nd:YAG laser posterior capsulotomy after the initial surgery, and one patient is currently under consideration for laser posterior capsulotomy.
  
  
  CONCLUSIONS
  Radiotherapy increased posterior subcapsule opacification at a relatively young age in primary OAML. Phacoemulsification was a manageable procedure without severe complications, and final visual outcomes were good. However, because after-cataracts progressed earlier than did senile cataracts, close follow-up should be considered for PCO management.
authors.affiliation: Department of Ophthalmology, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Won-Kyung
authors.initials: WK
authors.lastname: Cho
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Lee
authors.forename: Ji-Sun
authors.initials: JS
authors.lastname: Paik
authors.forename: Seok-Goo
authors.initials: SG
authors.lastname: Cho
authors.forename: Suk-Woo
authors.initials: SW
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D002386:Cataract / Q000453:epidemiology* / Q000209:etiology; D005134:Eye Neoplasms / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011829:Radiation Dosage; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Cataract; Ocular adnexal mucosa-associated lymphoid tissue lymphoma; Radiotherapy
references.citation: Am J Hematol. 2011 Mar;86(3):262-6
references.pmid: 21328439
references.citation: Br J Ophthalmol. 2011 Feb;95(2):227-30
references.pmid: 20576779
references.citation: Am J Ophthalmol. 2010 Aug;150(2):248-53
references.pmid: 20541740
references.citation: Arch Pathol Lab Med. 2009 Aug;133(8):1262-7
references.pmid: 19653722
references.citation: Ophthalmic Plast Reconstr Surg. 2007 Mar-Apr;23(2):94-9
references.pmid: 17413620
references.citation: Int J Radiat Oncol Biol Phys. 2010 May 1;77(1):86-91
references.pmid: 19632068
references.citation: Am J Ophthalmol. 2007 Feb;143(2):311-316
references.pmid: 17184716
references.citation: Ophthalmology. 1998 Jul;105(7):1213-21
references.pmid: 9663224
references.citation: Strahlenther Onkol. 2007 Jan;183(1):17-22
references.pmid: 17225941
references.citation: Phys Med Biol. 2010 Jul 21;55(14):4047-62
references.pmid: 20601777
references.citation: Radiother Oncol. 2009 Feb;90(2):236-41
references.pmid: 18950885
references.citation: Radiat Res. 2010 Dec;174(6):889-94
references.pmid: 21128813
references.citation: J Cataract Refract Surg. 2000 Aug;26(8):1176-82
references.pmid: 11008045
references.citation: Ophthalmologica. 2007;221(4):233-7
references.pmid: 17579288
references.citation: Graefes Arch Clin Exp Ophthalmol. 2000 Dec;238(12):942-8
references.pmid: 11196355
references.citation: Semin Ophthalmol. 2006 Jul-Sep;21(3):171-80
references.pmid: 16912015
references.citation: Radiat Res. 2009 Jul;172(1):1-9
references.pmid: 19580502
references.citation: Anticancer Drugs. 2008 Aug;19(7):673-80
references.pmid: 18594208
references.citation: Blood. 2009 Jul 16;114(3):501-10
references.pmid: 19372259
references.citation: Indian J Ophthalmol. 2009 Mar-Apr;57(2):91-7
references.pmid: 19237780
references.citation: Ann Oncol. 2008 May;19(5):835-46
references.pmid: 17986622
references.citation: Radiat Oncol. 2009 Dec 07;4:60
references.pmid: 19968864