title: The challenge of managing pulmonary arterial hypertension in adults with congenital heart disease.
abstract: A significant number of adult patients with congenital heart disease suffer from pulmonary arterial hypertension leading to a markedly increased morbidity and mortality. Some defects may be eligible for operative or interventional repair in adulthood but careful selection of candidates is crucial. With the emergence of disease-targeting therapies, symptomatic improvement and stabilization have become possible while the impact on survival currently remains unclear.
authors.affiliation: Adult Congenital and Valvular Heart Disease Center, Dept. of Cardiology and Angiology, University Hospital Münster, Münster, Germany. robert.radke@ukmuenster.de
authors.forename: Robert M
authors.initials: RM
authors.lastname: Radke
authors.forename: Gerhard-Paul
authors.initials: GP
authors.lastname: Diller
authors.forename: Helmut
authors.initials: H
authors.lastname: Baumgartner
mesh_terms: D000328:Adult; D000367:Age Factors; D065627:Familial Primary Pulmonary Hypertension; D006330:Heart Defects, Congenital / Q000503:physiopathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D018579:Patient Selection; D013534:Survival