title: The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development.
abstract: Aberrant gene expression is the cause and the consequence of tumorigenesis. A major component of gene expression is translation regulation; a process whose main players are RNA-binding-proteins (RBPs). More than 800 RBPs have been identified in the human genome and several of them have been shown to control gene networks associated with relevant cancer processes. A more systematic characterization of RBPs starts to reveal that similar to transcription factors, they can function as tumor suppressors or oncogenes. A relevant example is Musashi1 (Msi1), which is emerging as a critical regulator of tumorigenesis in multiple cancer types, including colon cancer. Msi1 is a stem marker in several tissues and is critical in maintaining the balance between self-renewal and differentiation. However, a boost in Msi1 expression can most likely lead cells towards an oncogenic pathway. In this article, we discuss the parallels between Msi1 function in normal renewal of intestinal epithelium and in colon cancer.
authors.affiliation: Centre de Génétique et de Physiologie Moléculaire et Cellulaire, Université Claude Bernard Lyon 1, France. 16 Rue Raphael Dubois, 69622 Villeurbanne, Cedex France.
authors.forename: Michelina
authors.initials: M
authors.lastname: Plateroti
authors.forename: Patricia Rosa
authors.initials: PR
authors.lastname: de Araujo
authors.forename: Acarizia Eduardo
authors.initials: AE
authors.lastname: da Silva
authors.forename: Luiz O F
authors.initials: LO
authors.lastname: Penalva
keywords: Colon cancer; Musashi1; RNA-binding proteins; Translation regulation
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