title: [Dexmedetomidine improves oxygenation during one-lung ventilation in balanced anesthesia with propofol-fentanyl in adults].
abstract: OBJECTIVE
  To investigate the effect of dexmedetomidine on oxygenation function in adult patients with balanced anesthesia by propofol-fentanyl under one-lung ventilation (OLV).
  
  
  METHODS
  Twenty-two patients undergoing thoracic operation were randomly divided into the study group and control group, both receiving propofol and fentanyl balanced anesthesia. In the study group, additional infusion of dexmedetomidine (0.3 µg/kg loading dose, 0.3 µg·kg(-1)·h(-1) maintenance dose) was administered, and the patients in the control group received only normal saline. Arterial blood samples were obtained at 4 time points from each patient during anesthesia for blood gas analysis.
  
  
  RESULTS
  In the study group, the pH values remained stable, the oxygenation index tended to decline progressively, but the incidence of hypoxemia was low; in the control group, the pH value and oxygenation index both declined progressively with a higher incidence of hypoxemia.
  
  
  CONCLUSIONS
  Dexmedetomidine can better maintain the oxygenation function of OLV patients in balanced anesthesia by propofol and fentanyl, and its mechanism may be related to the decreased dose of propofol used.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Ji'nan University, Guangzhou, China. 13903067258@139.com
authors.forename: Yong
authors.initials: Y
authors.lastname: Lai
authors.forename: Yalan
authors.initials: Y
authors.lastname: Li
authors.forename: Yuyong
authors.initials: Y
authors.lastname: Liu
authors.forename: Xuemei
authors.initials: X
authors.lastname: Peng
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Zou
mesh_terms: D000328:Adult; D058126:Balanced Anesthesia; D001784:Blood Gas Analysis; D020927:Dexmedetomidine / Q000494:pharmacology*; D005260:Female; D005283:Fentanyl; D006801:Humans; D008297:Male; D008875:Middle Aged; D061810:One-Lung Ventilation; D015742:Propofol
chemical_list: D020927:Dexmedetomidine; D005283:Fentanyl; D015742:Propofol