title: A new player SETs in myeloid malignancy.
abstract: Recent studies have identified recurrent mutations in SETBP1, the gene that encodes SET-binding protein 1, in several types of myeloid malignancies, including chronic myeloid and acute myeloid leukemias. The identified mutations frequently target the SKI-homologous domain, although the exact pathogenic mechanisms remain unknown.
authors.forename: Thomas
authors.initials: T
authors.lastname: Trimarchi
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Ntziachristos
authors.forename: Iannis
authors.initials: I
authors.lastname: Aifantis
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D059472:Exome; D005260:Female; D006801:Humans; D053616:Janus Kinase 3 / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics*; D054429:Leukemia, Myelomonocytic, Juvenile / Q000235:genetics*; D008297:Male; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D009687:Nuclear Proteins; C425066:SETBP1 protein, human; D053616:Janus Kinase 3
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