title: A co-stimulatory trap set by myeloid leukemia cells.
abstract: The straightforward notion that tumor cells always exert immunosuppressive functions has been contradicted by the finding that myeloid leukemia cells can express potent co-stimulatory molecules. Indeed, the co-stimulatory support offered by leukemia cells can provoke helper T-cell responses. Unfavorably, this interaction allows leukemia cells to acquire immunosuppressive capacities.
authors.affiliation: Department of Basic Oncology; Hacettepe University Cancer Institute; Ankara, Turkey.
authors.forename: Gunes
authors.initials: G
authors.lastname: Esendagli
keywords: ICOS; PD1; cancer; co-stimulation; immune evasion
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