title: Designing the magic bullet? The advancement of immuno-PET into clinical use.
abstract: The development of noninvasive imaging techniques using monoclonal antibodies (mAbs) is a quickly evolving field. Immuno-PET uses positron-emitting isotopes to track the localization of mAbs with excellent image quality. Procedures for labeling mAbs with (89)Zr or (124)I using good manufacturing procedures have been established, and therefore these radiopharmaceuticals are being investigated for clinical use. This short review will focus on immuno-PET with full mAbs using long-lived positron-emitting isotopes ((89)Zr and (124)I) over the past 5 y and discuss their progress into clinical use.
authors.affiliation: Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Wright
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Lapi
mesh_terms: D000911:Antibodies, Monoclonal; D006801:Humans; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D049268:Positron-Emission Tomography / Q000379:methods*; D015040:Zirconium
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D015040:Zirconium
keywords: 124I; 89Zr; PET; immuno-PET; positron