title: Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility.
abstract: OBJECTIVE
  The relevance of the cytidine diphosphate-choline and Rho GTPases pathways in the pathogenesis of cancer has been previously demonstrated. We investigate by a case-control association study if genetics variants in these pathways are associated with risk of developing lung cancer.
  
  
  METHODS
  Thirty-seven tag SNPs were evaluated as risk factor of NSCLC in 897 cases and 904 controls.
  
  
  RESULTS
  Six SNPs were nominally associated with lung cancer risk, which were not significant after the Bonferroni correction for multiple comparisons. No association was observed with the remaining 31 analyzed SNPs, neither it was found significant in haplotype frequencies.
  
  
  CONCLUSIONS
  Although the implication of the two pathways investigated in our study in carcinogenesis is well established, our null results suggest that common genetic variants in CDP-choline and Rho GTPases-related genes are not risk factors for lung cancer.
authors.affiliation: Division of Translational Oncology, Health Research Institute and University Hospital Fundación Jiménez Díaz, Madrid, Spain, arancha.cebrian@fjd.es.
authors.forename: A
authors.initials: A
authors.lastname: Cebrián
authors.forename: M
authors.initials: M
authors.lastname: Taron
authors.forename: N
authors.initials: N
authors.lastname: Sala
authors.forename: E
authors.initials: E
authors.lastname: Ardanaz
authors.forename: M-D
authors.initials: MD
authors.lastname: Chirlaque
authors.forename: N
authors.initials: N
authors.lastname: Larrañaga
authors.forename: M-L
authors.initials: ML
authors.lastname: Redondo
authors.forename: M-J
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: T
authors.initials: T
authors.lastname: Gómez del Pulgar
authors.forename: C
authors.initials: C
authors.lastname: Camps
authors.forename: R
authors.initials: R
authors.lastname: Rosell
authors.forename: C A
authors.initials: CA
authors.lastname: González
authors.forename: J C
authors.initials: JC
authors.lastname: Lacal
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism; D002797:Choline Kinase / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D020741:rho GTP-Binding Proteins / Q000235:genetics
chemical_list: D010743:Phospholipids; C517212:CHKA protein, human; C542592:CHKB protein, human; D002797:Choline Kinase; D020741:rho GTP-Binding Proteins
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