title: Quantitative structure--clearance relationships of acidic drugs.
abstract: Drug clearance is the most important of all pharmacokinetic parameters. It is affected significantly by the binding of drugs to serum proteins. Only the free (unbound) fraction of the drug is able to be cleared. The unbound clearance CLu is the clearance with reference to unbound drug in plasma Cu. CLu is independent of the plasma protein binding and depends only on drug chemical structure and properties. In the present study, the relationship between the unbound clearance CLu and the chemical structures of acidic drugs was modeled by a quantitative structure-clearance relationship (QSCLR) approach. The derived models were used to reveal the main structural features important for CLu. It was found that the lipophilicity of acidic drugs and the presence of substituents in the aromatic rings, cyano group, and/or nonpolar hydrogen atoms increase the rate of unbound clearance. The presence of sulfonyl groups, quaternary carbon atoms and/or eight-member ring system decreases the unbound clearance of drugs. Additionally, QSCLR models for renal, hepatic, and biliary clearances were derived.
authors.affiliation: Faculty of Pharmacy, Medical University of Sofia , Sofia 1000, Bulgaria.
authors.forename: Zvetanka
authors.initials: Z
authors.lastname: Zhivkova
authors.forename: Irini
authors.initials: I
authors.lastname: Doytchinova
mesh_terms: D000465:Algorithms; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations; D010599:Pharmacokinetics; D013329:Structure-Activity Relationship
chemical_list: D004364:Pharmaceutical Preparations