title: Histopathological features of the outer membrane of chronic subdural hematoma and correlation with clinical and radiological features.
abstract: We compared the histopathological features of the outer membrane of a chronic subdural hematoma (CSH) with its clinico-radiological presentation in patients. One hundred and fifty-six patients undergoing surgery for CSH were prospectively included in this study. Histopathological specimens of the outer neomembrane obtained intraoperatively were studied. Histological features were classified into four types and analyzed in relation to the Glasgow Coma Scale (GCS) score at presentation and radiological features. On histopathological examination, there were no cases of type I, 42.3% cases of type II and 34.6% cases of type III and 23.1% cases of types IV CSH neomembranes. Patients presenting with a GCS <13 exclusively had type II neomembranes. Increased radiodensity and thickness of the hematoma correlated with type IV neomembranes. This study may serve as an incentive to investigate the histopathology of CSH membranes in predicting outcomes and the recurrence of subdural hemorrhage after drainage surgery.
authors.affiliation: Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 350 W Thomas Rd, Phoenix, AZ 85013, USA.
authors.forename: Gurpreet S
authors.initials: GS
authors.lastname: Gandhoke
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kaif
authors.forename: Lawrence
authors.initials: L
authors.lastname: Choi
authors.forename: Richard W
authors.initials: RW
authors.lastname: Williamson
authors.forename: Peter
authors.initials: P
authors.lastname: Nakaji
mesh_terms: D016009:Chi-Square Distribution; D004322:Drainage / Q000379:methods; D005260:Female; D015600:Glasgow Coma Scale; D020200:Hematoma, Subdural, Chronic / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008578:Meninges / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D015898:Tomography Scanners, X-Ray Computed
keywords: Chronic subdural hematoma; Histopathology; Neomembrane