title: Kidney function in living donors undergoing nephrectomy by sevoflurane or desflurane anesthesia.
abstract: OBJECTIVE
  Although there is no clinical evidence of nephrotoxicity with the volatile anesthetics currently used in general anesthesia, a better agent should be needed in terms of preserving postoperative renal function in living kidney donors who have only single remaining kidney. The purpose of the current retrospective, single-center study was to evaluate and compare renal function of living kidney donors after nephrectomy under either sevoflurane or desflurane anesthesia.
  
  
  METHODS
  From January 2006 through December 2011, a total of 228 donors undergoing video assisted minilaparotomy surgery nephrectomy for kidney donation were retrospectively enrolled in the current study. The donors were categorized into a sevoflurane group or desflurane group based on the type of volatile anesthetic used. We collected laboratory data from the patients preoperatively, immediately after the operation, on the first postoperative day and on the third postoperative day. We also compared renal function of the kidney donors after donor nephrectomy by comparing creatinine level and estimated glomerular filtration rate (eGFR).
  
  
  RESULTS
  The decrease in renal function after surgery in both groups was the most prominent on the first postoperative day. There were no significant differences between the two groups in postoperative changes of creatinine or eGFR.
  
  
  CONCLUSIONS
  Sevoflurane and desflurane can be used safely as volatile anesthetics in donors undergoing nephrectomy.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Jeong-Rim
authors.initials: JR
authors.lastname: Lee
authors.forename: Myoung-Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Sung-Yeon
authors.initials: SY
authors.lastname: Ham
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Choi
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000379:methods; D018685:Anesthetics, Inhalation / Q000009:adverse effects / Q000627:therapeutic use*; D000077335:Desflurane; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects / Q000627:therapeutic use*; D009392:Nephrectomy; D011183:Postoperative Complications; D012189:Retrospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane
keywords: Desflurane; living donors; nephrectomy; sevoflurane
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