title: Adverse drug reaction monitoring of antidepressants in the psychiatry outpatients department of a tertiary care teaching hospital.
abstract: BACKGROUND
  Depression is a prevalent mental disorder and the 4(th) leading cause of disability in the world as per the World Health Organization (WHO). The adverse Drug Reactions (ADRs) to antidepressants are common and they can lead to a non compliance or even a discontinuation of the therapy. This study entitled us to monitor the ADR profile of the antidepressants in a tertiary care teaching hospital.
  
  
  METHODS
  A longitudinal, observational study was conducted in the Outpatients Department of Psychiatry in S.C.B. Medical College and Hospital l in collaboration with the I.M.S and SUM Hospital. A total of 160 cases were studied for ADRs by using a predesigned CDSCO form. The patients who were on TCAs, SSRIs and newer antidepressants (SNRIs/NDRIs) were assessed by doing physical examinations, neurological examinations and relevant lab tests. The causalities were assessed by the criteria of the WHO-UMC. The analysis of ADRs was done by using the Chi square test.
  
  
  RESULTS
  Among the 160 patients who took antidepressants, 26.87% reported ADRs, with at least one possible causality.None were labeled as certain, as a rechallenge was not performed.ADRs were mostly observed in polytherapy (14.37%) and with antidepressants like TCAs (58.84%).
  
  
  CONCLUSIONS
  Agitation, anxiety and insomnia were the common ADRs which were associated with the use of antidepressants. This study offers a representative profile of the ADRs which can be expected in the Psychiatry Outpatients Department and due care must be taken to avoid these ADRs.
authors.affiliation: Assistant Professor, IMS & SUM Hospital, SOA University , Bhubaneswar - 03, Odisha, India .
authors.forename: Swati
authors.initials: S
authors.lastname: Mishra
authors.forename: Trupti Rekha
authors.initials: TR
authors.lastname: Swain
authors.forename: Manjushree
authors.initials: M
authors.lastname: Mohanty
keywords: Antidepressants; Depression; WHO-UMC
references.citation: Br J Clin Pharmacol. 2006 Aug;62(2):135-7
references.pmid: 16842386
references.citation: Indian J Pharmacol. 2011 Feb;43(1):36-9
references.pmid: 21455419
references.citation: J Consult Clin Psychol. 1991 Oct;59(5):704-14
references.pmid: 1835464
references.citation: Drug Saf. 2009;32(4):325-33
references.pmid: 19388723
references.citation: Br J Clin Pharmacol. 2007 Apr;63(4):431-7
references.pmid: 17076698
references.citation: Pharmacopsychiatry. 2004 Mar;37 Suppl 1:S39-45
references.pmid: 15052513
references.citation: Am J Psychiatry. 1992 Oct;149(10):1335-40
references.pmid: 1530069
references.citation: N Engl J Med. 1988 Aug 11;319(6):348-53
references.pmid: 3292920
references.citation: J Affect Disord. 2000 Aug;59(2):149-57
references.pmid: 10837883