title: Pilot controlled trial of the adherence readiness program: an intervention to assess and sustain HIV antiretroviral adherence readiness.
abstract: To pilot the adherence readiness program, 60 patients planning to start HIV antiretrovirals were assigned to usual care (n = 31) or the intervention (n = 29), of whom 54 started antiretrovirals and were followed for up to 24 weeks. At week 24, the intervention had a large effect (50.0 % vs. 16.7 %, d = 0.75) on optimal dose-timing (85+ % doses taken on time) and small effect (54.2 % vs. 43.3 %, d = 0.22) on optimal dose-taking (85+ % doses taken) electronically monitored adherence, and medium effect on undetectable viral load (62 % 0.5 % vs. 43.4 %, d = 0.41), compared to usual care. These intervention benefits on adherence and viral suppression warrant further investigation.
authors.affiliation: RAND Corporation, 1776 Main St., Santa Monica, CA, 90407, USA, gwagner@rand.org.
authors.forename: Glenn J
authors.initials: GJ
authors.lastname: Wagner
authors.forename: Paul
authors.initials: P
authors.lastname: Lovely
authors.forename: Stefan
authors.initials: S
authors.lastname: Schneider
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D002140:California / Q000453:epidemiology; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D037001:Directive Counseling / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D015438:Health Behavior; D006801:Humans; D008297:Male; D055118:Medication Adherence; D010865:Pilot Projects; D015397:Program Evaluation; D012646:Self Administration; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents
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