title: Casein phosphopeptide-amorphous calcium phosphate and glass ionomer show distinct effects in the remineralization of proximal artificial caries lesion in situ.
abstract: This study aimed to compare the ability of casein-phosphopeptide amorphous-calcium-phosphate (CPP-ACP) and glass-ionomer (GI) in remineralizing proximal artificial caries lesions (ACLs). Molar enamel-slabs were divided into: original-lesion control, intra-oral controls, and experimental (CPP-ACP or GI) groups. Specimens received ACLs and were bonded on subject maxillary first molars. After 4-weeks, mineral density (MD) was analyzed by μCT. Compared to control, CPP-ACP increased MD at 0-38/68-84 microns and the GI group had an increase at 0-68 microns, with a greater increase in MD compared to the CPP-ACP group from 0-53 microns. The mean percent remineralization (%R) showed differences between the GI, CPP-ACP groups and their paired controls. GI tended to increase remineralization more than CPP-ACP. In conclusion, CPP-ACP and GI demonstrated distinct remineralizing ability. GI induced greater remineralization in the superficial lesion, while CPP-ACP remineralized the lesion body. Their effects on percent remineralization and reducing lesion depth of proximal ACLs were similar.
authors.affiliation: Faculty of Dentistry, Chulalongkorn University, 34 Henri-Dunant Rd, Patumwan, Bangkok 10330, Thailand.
authors.forename: Rathapong
authors.initials: R
authors.lastname: Thepyou
authors.forename: Wanvipa
authors.initials: W
authors.lastname: Chanmitkul
authors.forename: Ornnicha
authors.initials: O
authors.lastname: Thanatvarakorn
authors.forename: Hidenori
authors.initials: H
authors.lastname: Hamba
authors.forename: Wanwalai
authors.initials: W
authors.lastname: Chob-Isara
authors.forename: Chutima
authors.initials: C
authors.lastname: Trairatvorakul
authors.forename: Junji
authors.initials: J
authors.lastname: Tagami
mesh_terms: D002327:Cariostatic Agents / Q000627:therapeutic use*; D002364:Caseins / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003731:Dental Caries / Q000473:pathology / Q000628:therapy*; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects; D003802:Dentifrices / Q000627:therapeutic use; D004311:Double-Blind Method; D017886:Durapatite / Q000032:analysis; D005459:Fluorides / Q000627:therapeutic use; D005899:Glass Ionomer Cements / Q000627:therapeutic use*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008903:Minerals / Q000032:analysis; D010710:Phosphates / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods*; D055114:X-Ray Microtomography / Q000379:methods; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; D003802:Dentifrices; C493186:Fuji VII; D005899:Glass Ionomer Cements; D008903:Minerals; D010710:Phosphates; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; C012980:fluorophosphate; D017886:Durapatite; D005459:Fluorides