title: Synthesis of highly substituted 4H-pyrido[1,2-a]pyrimidines via a one-pot three-component condensation reaction.
abstract: A one-pot three-component reaction, involving condensation of 2-aminopyridines, aldehydes, and ketones/aldehydes under trifluoromethanesulfonic acid catalysis, provides rapid access to highly substituted novel 4H-pyrido[1,2-a]pyrimidines.
authors.affiliation: The Center for Combinatorial Chemistry and Drug Discovery, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University , 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.forename: Jinbao
authors.initials: J
authors.lastname: Xiang
authors.forename: Guochen
authors.initials: G
authors.lastname: Bao
authors.forename: Qun
authors.initials: Q
authors.lastname: Dang
authors.forename: Xu
authors.initials: X
authors.lastname: Bai
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000631:Aminopyridines / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000631:Aminopyridines; D007659:Ketones; D008698:Mesylates; D011743:Pyrimidines; C012077:trifluoromethanesulfonic acid; C032439:alpha-aminopyridine