title: BRAF-targeted therapy and immune responses to melanoma.
abstract: Type I BRAF inhibitors and immunotherapy constitute two new exciting approaches for the treatment of advanced malignant melanoma. We have recently elucidated a role for host C-C chemokine receptor type 2 (CCR2) in the antineoplastic effects of type I BRAF inhibitors in mice, supporting the therapeutic potential of combining BRAF inhibitors with immunotherapy.
authors.affiliation: Immunology in Cancer and Infection Laboratory; Queensland Institute of Medical Research; Herston, QLD Australia ; Department of Pathology; University of Melbourne; Parkville, VIC Australia.
authors.forename: Shin Foong
authors.initials: SF
authors.lastname: Ngiow
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Knight
authors.forename: Antoni
authors.initials: A
authors.lastname: Ribas
authors.forename: Grant A
authors.initials: GA
authors.lastname: McArthur
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Smyth
keywords: BRAF; T cell; checkpoint; immunity; melanoma
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