title: Trauma-induced coagulopathy.
abstract: Hemorrhage is the leading cause of death in trauma patients who arrive alive at hospital. This type of hemorrhage has a "coagulopathic" component, specific to major trauma and associated with poor outcomes. Over the last decade, a better understanding of this trauma-induced coagulopathy lead to a new therapeutic approach requiring earlier and more aggressive management. This hemostatic resuscitation includes early activation of massive transfusion protocols with: 1) immediate delivery of blood packs with high ratios for RBC units: fresh frozen plasma: platelet-concentrates; 2) antifibrinolytics; 3) substitution of coagulation factors. However, early identification of coagulopathic patients requiring aggressive hemostatic resuscitation remains challenging, with an increasing role of point of care devices for hemostatic diagnosis and monitoring. Efforts have to be focused on the early diagnosis of coagulopathy for immediate delivery of blood products and coagulation factors to the right, accurately screened patients through pre-established protocols within the golden hour.
authors.affiliation: Service d'anesthésie-réanimation chirurgicale, université Paris-Descartes, hôpital Cochin, Assistance Publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. annegodier@yahoo.fr
authors.forename: A
authors.initials: A
authors.lastname: Godier
authors.forename: S
authors.initials: S
authors.lastname: Susen
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D001803:Blood Transfusion; D006470:Hemorrhage / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006487:Hemostasis; D006801:Humans; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications*
chemical_list: D000933:Antifibrinolytic Agents; D001779:Blood Coagulation Factors
keywords: Coagulopathie; Coagulopathy; Hemorrhage; Hémorragie; Trauma