title: Adipokines as drug targets in joint and bone disease.
abstract: White adipose tissue is now recognized to be a multifactorial organ secreting several adipose-derived factors that have been collectively termed 'adipokines'. Adipokines are pleiotropic molecules that contribute to the so-called 'low-grade inflammatory state' of obese subjects creating a cluster of metabolic aberrations including autoimmune and inflammatory diseases that affect joints and bone. The aim of this review is to present knowledge about the role of adipokines in bone and cartilage function, as well as in inflammatory and degenerative joint disease. We discuss clinical implications and then survey attempts to exploit this role for therapeutic gain, which holds potential as a novel approach for drug development in bone and joint disease.
authors.affiliation: SERGAS, Research Laboratory 9 (NEIRID LAB: Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela 15706, Spain.
authors.forename: Morena
authors.initials: M
authors.lastname: Scotece
authors.affiliation: SERGAS, Research Laboratory 9 (NEIRID LAB: Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela 15706, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Conde
authors.affiliation: The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere 33014, Finland.
authors.forename: Katriina
authors.initials: K
authors.lastname: Vuolteenaho
authors.affiliation: The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere 33014, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Koskinen
authors.affiliation: SERGAS, Research Laboratory 9 (NEIRID LAB: Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela 15706, Spain.
authors.forename: Veronica
authors.initials: V
authors.lastname: López
authors.affiliation: SERGAS, Research Laboratory 9 (NEIRID LAB: Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela 15706, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Gómez-Reino
authors.affiliation: SERGAS, Research Laboratory 7 (Molecular and Cellular Cardiology), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela 15706, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Lago
authors.affiliation: The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere 33014, Finland.
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
authors.affiliation: SERGAS, Research Laboratory 9 (NEIRID LAB: Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela 15706, Spain. Electronic address: oreste.gualillo@sergas.es.
authors.forename: Oreste
authors.initials: O
authors.lastname: Gualillo
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D001847:Bone Diseases / Q000188:drug therapy* / Q000503:physiopathology; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D007592:Joint Diseases / Q000188:drug therapy* / Q000503:physiopathology; D058990:Molecular Targeted Therapy; D009765:Obesity / Q000503:physiopathology
chemical_list: D054392:Adipokines