title: Hematological improvement during iron-chelation therapy in myelodysplastic syndromes: the experience of the "Rete Ematologica Lombarda".
abstract: To analyze the unpredicted event of hematological improvement (HI) during iron-chelation therapy (ICT), we reviewed a series of 53 myelodysplastic patients with transfusion dependency in a retrospective study involving 8 centers afferent to the "Rete Ematologica Lombarda". According to the IWG response criteria published in the year 2000, we observed erythroid responses in 19 patients (35.1%), 5 major (9.2%) and 14 minor (25.9%). In the assessable patients, platelet response was 8/13 (61%) and neutrophil response was 13/17 (76.4%). Only in patients with erythroid improvement, multilineage responses were observed. Apparently, patients with greater erythropoiesis dysfunction may take more advantage.
authors.affiliation: Department of Hematology, AO Ospedale Niguarda Ca' Granda, Milan, Italy. alfredo.molteni@ospedaleniguarda.it
authors.forename: Alfredo
authors.initials: A
authors.lastname: Molteni
authors.forename: Marta
authors.initials: M
authors.lastname: Riva
authors.forename: Annamaria
authors.initials: A
authors.lastname: Pellizzari
authors.forename: Lorenza
authors.initials: L
authors.lastname: Borin
authors.forename: Alessandra
authors.initials: A
authors.lastname: Freyrie
authors.forename: Alessandra
authors.initials: A
authors.lastname: Freyre
authors.forename: Rosa
authors.initials: R
authors.lastname: Greco
authors.forename: Marta
authors.initials: M
authors.lastname: Ubezio
authors.forename: Massimo
authors.initials: M
authors.lastname: Bernardi
authors.forename: Alessio
authors.initials: A
authors.lastname: Fariciotti
authors.forename: Guido
authors.initials: G
authors.lastname: Nador
authors.forename: Michele
authors.initials: M
authors.lastname: Nichelatti
authors.forename: Emanuele
authors.initials: E
authors.lastname: Ravano
authors.forename: Enrica
authors.initials: E
authors.lastname: Morra
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count; D004909:Erythrocyte Indices; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000175:diagnosis / Q000628:therapy*; D012189:Retrospective Studies; D065227:Transfusion Reaction; D055815:Young Adult
chemical_list: D007502:Iron Chelating Agents; D005293:Ferritins; D007501:Iron
keywords: Hematological improvement; Iron-chelation therapy; Myelodysplastic syndromes