title: Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes.
abstract: Parkinson disease (PD) is a multifactorial neurodegenerative disorder with high incidence in the elderly, where environmental and genetic factors are involved in etiology. In addition, epigenetic mechanisms, including deregulation of DNA methylation have been recently associated to PD. As accurate diagnosis cannot be achieved pre-mortem, identification of early pathological changes is crucial to enable therapeutic interventions before major neuropathological damage occurs. Here we investigated genome-wide DNA methylation in brain and blood samples from PD patients and observed a distinctive pattern of methylation involving many genes previously associated to PD, therefore supporting the role of epigenetic alterations as a molecular mechanism in neurodegeneration. Importantly, we identified concordant methylation alterations in brain and blood, suggesting that blood might hold promise as a surrogate for brain tissue to detect DNA methylation in PD and as a source for biomarker discovery.
authors.affiliation: Department of Neuroscience; University of California San Diego; La Jolla, CA USA; Department of Pathology; University of California San Diego; La Jolla, CA USA.
authors.forename: Eliezer
authors.initials: E
authors.lastname: Masliah
authors.affiliation: Department of Pathology; University of California San Diego; La Jolla, CA USA.
authors.forename: Wilmar
authors.initials: W
authors.lastname: Dumaop
authors.affiliation: Department of Neuroscience; University of California San Diego; La Jolla, CA USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Galasko
authors.affiliation: Department of Neuroscience; University of California San Diego; La Jolla, CA USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Desplats
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D016022:Case-Control Studies; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D010300:Parkinson Disease / Q000097:blood / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: DNA methylation; Parkinson disease; brain; epigenetics; genome-wide methylation; neurodegeneration; peripheral blood leukocytes
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