title: Density estimation on multivariate censored data with optional Pólya tree.
abstract: Analyzing the failure times of multiple events is of interest in many fields. Estimating the joint distribution of the failure times in a non-parametric way is not straightforward because some failure times are often right-censored and only known to be greater than observed follow-up times. Although it has been studied, there is no universally optimal solution for this problem. It is still challenging and important to provide alternatives that may be more suitable than existing ones in specific settings. Related problems of the existing methods are not only limited to infeasible computations, but also include the lack of optimality and possible non-monotonicity of the estimated survival function. In this paper, we proposed a non-parametric Bayesian approach for directly estimating the density function of multivariate survival times, where the prior is constructed based on the optional Pólya tree. We investigated several theoretical aspects of the procedure and derived an efficient iterative algorithm for implementing the Bayesian procedure. The empirical performance of the method was examined via extensive simulation studies. Finally, we presented a detailed analysis using the proposed method on the relationship among organ recovery times in severely injured patients. From the analysis, we suggested interesting medical information that can be further pursued in clinics.
authors.affiliation: Department of Statistics and Department of Health Research & Policy, Stanford University, Stanford, CA 94305, USA.
authors.forename: Junhee
authors.initials: J
authors.lastname: Seok
authors.forename: Lu
authors.initials: L
authors.lastname: Tian
authors.forename: Wing H
authors.initials: WH
authors.lastname: Wong
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D002319:Cardiovascular System / Q000473:pathology; D002490:Central Nervous System / Q000473:pathology; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D006801:Humans; D015999:Multivariate Analysis; D016019:Survival Analysis; D014947:Wounds and Injuries / Q000473:pathology
keywords: Multivariate survival analysis; Non-parametric Bayesian; Optional Pólya tree
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