title: Metal presence in hair after metal-on-metal resurfacing arthroplasty.
abstract: The elevation of metal levels in serum and urine during post-operative follow-up is a frequent find following the implantation of certain models of metal-on-metal hip prostheses. Among 45 patients with the same resurfacing prostheses, chromium (Cr) and cobalt (Co) levels in serum and urine were determined at 3, 4, 5, and 6 years after surgery. In the same period, levels of Cr, Co and molibdene (Mo) in scalp hair were also measured. Mean Cr and Co levels in serum were 8.29 µg/L (SD 17.97) and 8.38 µg/L (SD 21.97), respectively, whereas in urine levels were 16.20 µg/L (SD SD 32.55) and 75.40 µg/L (SD 190.86), respectively. In hair, mean Cr level were 163.27 µg/g (SD 300.62), mean Co level 61.98 µg/g (SD 126.48), and Mo 31.36 µg/g (SD 37.86). A high concordance was observed between chromium-urine and chromium-serum and between cobalt-urine and cobalt-hair. A moderate concordance was present between cobalt-urine and cobalt-serum, and between cobalt-hair and cobalt-serum. Eleven patients required revision surgery, five of them due to metallosis and periarticular cyst. At 1 year after reintervention, analytics were performed again and the following decrease rates were found: 42.8% in Cr levels, 51.1% in Mo levels, and 90.3% in Co levels.
authors.affiliation: Department of Pharmacy, Hospital San Agustín, Heros s/n, 33400 Avilés, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Rodríguez de la Flor
authors.forename: Daniel
authors.initials: D
authors.lastname: Hernández-Vaquero
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fernández-Carreira
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods*; D002857:Chromium / Q000032:analysis; D003035:Cobalt / Q000032:analysis; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008297:Male; D008670:Metals / Q000032:analysis*; D008875:Middle Aged; D008982:Molybdenum / Q000032:analysis
chemical_list: D008670:Metals; D002857:Chromium; D003035:Cobalt; D008982:Molybdenum
keywords: hair; hip; metal levels; metallosis; resurfacing arthroplasty