title: Life-years gained by smoking cessation after percutaneous coronary intervention.
abstract: Previous studies have shown that smoking cessation after a cardiac event reduces the risk of subsequent mortality in patients. The aim of this study was to describe the effect of smoking cessation in terms of prolonged life-years gained. The study sample comprised 856 patients who underwent percutaneous coronary intervention (PCI; balloon angioplasty) during 1980 to 1985. Patients were followed up for 30 years and smoking status at 1 year could be retrieved in 806 patients. The 27 patients who died within 1 year were excluded from the analysis. The median follow-up was 19.5 years (interquartile range 6.0 to 23.0). Cumulative 30-year survival rate was 29% in the group of patients who quit smoking and 14% in persistent smokers (p = 0.005). After adjustment for baseline characteristics at the time of PCI, smoking cessation remained an independent predictor of lesser mortality (adjusted hazard ratio 0.57, 95% confidence interval 0.46 to 0.71). The estimated life expectancy was 18.5 years in those who quit smoking and 16.4 years in the persistent smokers (p <0.0001). In conclusion, in patients with coronary heart disease who underwent PCI in the late 1980s, smoking cessation resulted in at least 2.1 life-years gained.
authors.affiliation: Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Sanneke P M
authors.initials: SP
authors.lastname: de Boer
authors.forename: Patrick W J C
authors.initials: PW
authors.lastname: Serruys
authors.forename: Gideon
authors.initials: G
authors.lastname: Valstar
authors.forename: Mattie J
authors.initials: MJ
authors.lastname: Lenzen
authors.forename: Peter J
authors.initials: PJ
authors.lastname: de Jaegere
authors.forename: Felix
authors.initials: F
authors.lastname: Zijlstra
authors.forename: Eric
authors.initials: E
authors.lastname: Boersma
authors.forename: Ron T
authors.initials: RT
authors.lastname: van Domburg
mesh_terms: D003327:Coronary Disease / Q000401:mortality* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D008017:Life Expectancy / Q000639:trends*; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D062645:Percutaneous Coronary Intervention; D011184:Postoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000401:mortality; D016540:Smoking Cessation / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D015996:Survival Rate; D013997:Time Factors