title: The antisaccade task performance deficit and specific CNV abnormalities in patients with stereotyped paraphilia and schizophrenia.
abstract: Antisaccade task performance and mean amplitudes of slow cortical potentials (contingent negative variation--CNV) were investigated in 19 healthy volunteers, 16 schizophrenic patients (SP), and 12 patients with stereotyped form of paraphilia (PP). Compared with healthy subjects, schizophrenic and paraphilic patients committed significantly more erroneous saccades. The clear between-group CNV differences were observed during the early CNV stage that is associated with cognitive aspects of preparatory set. In SP, as compared to controls, the significant decline of CNV amplitude was found at frontal-central area. PP have demonstrated the lack of CNV over central and parietal regions, but their CNV amplitudes in frontal area did not differ from values of control group. Thus, two distinct types of CNV abnormalities have been found. The SP results have been interpreted as support for frontal dysfunction in schizophrenia. The disconnection between prefrontal cortex, sensorimotor cortex, and related subcortical structures is hypothesized in paraphilia group.
authors.affiliation: National Serbsky Centre for Social and Forensic Psychiatry, 119922, Moscow, Russian Federation.
authors.forename: Anna V
authors.initials: AV
authors.lastname: Kirenskaya
authors.affiliation: National Serbsky Centre for Social and Forensic Psychiatry, 119922, Moscow, Russian Federation.
authors.forename: Maxim Y
authors.initials: MY
authors.lastname: Kamenskov
authors.affiliation: National Serbsky Centre for Social and Forensic Psychiatry, 119922, Moscow, Russian Federation.
authors.forename: Vadim V
authors.initials: VV
authors.lastname: Myamlin
authors.affiliation: National Serbsky Centre for Social and Forensic Psychiatry, 119922, Moscow, Russian Federation.
authors.forename: Vladimir Y
authors.initials: VY
authors.lastname: Novototsky-Vlasov
authors.affiliation: National Serbsky Centre for Social and Forensic Psychiatry, 119922, Moscow, Russian Federation.
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Tkachenko
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D016022:Case-Control Studies; D004569:Electroencephalography; D004585:Electrooculography; D005071:Evoked Potentials / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D010262:Paraphilic Disorders / Q000503:physiopathology*; D010775:Photic Stimulation; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D055815:Young Adult
keywords: CNV; antisaccades; forensic science; paraphilia; schizophrenia
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