title: Cutaneous syringoma: a clinicopathologic study of 34 new cases and review of the literature.
abstract: BACKGROUND
  Syringoma is a benign adnexal tumor derived from intraepidermal eccrine duct.
  
  
  OBJECTIVE
  The aim of the study is to report the experience concerning syringoma by reviewing the clinical and histopathologic features of a series of 34 histologically diagnosed syringoma patients observed over a period of six years.
  
  
  METHODS
  Thirty-four patients were sorted into two groups, localized and generalized syringoma, according to the Friedman and Butler classification. Different histopathologic findings were recorded in specially designed questionnaires for further analysis.
  
  
  RESULTS
  Ninety-seven percent of the patients were females with the mean age of 27.6 years. The mean duration of the lesions before the presentations was six years. The diagnosis of syringoma was only considered in 23 patients (67.6%) and was the initial diagnosis in only 13 (38.2%) patients. All histological findings were seen more common in our cases. in comparison to the documented cases in the literature. Clear cell change of epithelial eccrine cells was 85.2% and there was no difference in the histopathological findings in the two groups. Our patients with generalized syringoma (GS) had a considerable lower age of onset than the ones with localized syringoma (LS) (P = 0.027).
  
  
  CONCLUSIONS
  Our patients with generalized syringoma were younger than the ones with localized syringoma. Distribution of the generalized syringoma was mainly in the chest and neck followed by the forearms whereas localized syringoma was mostly confined to the face, axilla and genitalia. There were also some conditions associated with our cases including sarcoidosis, calcinosis cutis and basal cell carcinoma.
authors.affiliation: Department of Dermatopathology, Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Ghanadan
authors.forename: Mohsen
authors.initials: M
authors.lastname: Khosravi
keywords: Eruptive; histopathology; immunohistochemistry; syringoma
references.citation: J Cutan Pathol. 2004 Apr;31(4):336-40
references.pmid: 15005692
references.citation: Clin Exp Dermatol. 1999 Sep;24(5):428-30
references.pmid: 10564342
references.citation: Indian J Dermatol. 2009;54(1):65-7
references.pmid: 20049275
references.citation: J Am Acad Dermatol. 1998 Dec;39(6):1032-3
references.pmid: 9843027
references.citation: J Cutan Pathol. 1991 Feb;18(1):20-7
references.pmid: 1850764
references.citation: Arch Dermatol. 1989 Aug;125(8):1119-20
references.pmid: 2547344
references.citation: Arch Dermatol. 1985 Jun;121(6):756-60
references.pmid: 3890761
references.citation: Int J Dermatol. 1986 Jul-Aug;25(6):397
references.pmid: 3759318
references.citation: J Eur Acad Dermatol Venereol. 2001 May;15(3):242-6
references.pmid: 11683289
references.citation: Int J Dermatol. 1992 Jun;31(6):437-8
references.pmid: 1512103
references.citation: J Cutan Pathol. 1997 Jul;24(6):370-6
references.pmid: 9243365
references.citation: Acta Derm Venereol. 1998 Nov;78(6):460-2
references.pmid: 9833049
references.citation: Indian J Dermatol. 2011 Jan;56(1):33-6
references.pmid: 21572788
references.citation: J Am Acad Dermatol. 2003 Aug;49(2):337-9
references.pmid: 12894094
references.citation: Dermatol Online J. 2004 Oct 15;10(2):19
references.pmid: 15530309
references.citation: Dermatol Online J. 2005 Dec 01;11(3):34
references.pmid: 16409930
references.citation: Cutis. 2000 Oct;66(4):259-62
references.pmid: 11109147
references.citation: Yale J Biol Med. 2002 Jul-Aug;75(4):207-10
references.pmid: 12784970
references.citation: Arch Dermatol. 1989 Jun;125(6):848-9
references.pmid: 2543332
references.citation: J Am Acad Dermatol. 2003 May;48(5 Suppl):S103-4
references.pmid: 12734492
references.citation: J Am Acad Dermatol. 1990 Aug;23(2 Pt 2):372-5
references.pmid: 2144304
references.citation: Cutis. 2001 Oct;68(4):293-5
references.pmid: 11710451
references.citation: Int J Dermatol. 1990 May;29(4):309-10
references.pmid: 2370124
references.citation: Am J Dermatopathol. 1992 Apr;14(2):115-21
references.pmid: 1373584
references.citation: Am J Dermatopathol. 2005 Aug;27(4):362-3
references.pmid: 16121064
references.citation: Yonsei Med J. 2007 Feb 28;48(1):35-40
references.pmid: 17326243
references.citation: Int J Dermatol. 1989 Mar;28(2):142-3
references.pmid: 2737815
references.citation: J Am Acad Dermatol. 2005 Sep;53(3):532-3
references.pmid: 16112373