title: Expedition of in vitro dissolution and in vivo pharmacokinetic profiling of sulfur nanoparticles based antimicrobials.
abstract: A comprehensive pharmacokinetic profiling of novel drugs and therapeutics is a definite prerequisite of drug discovery and development. The present study expedites the in vivo and in vitro pharmacokinetic properties of colloidal sulfur nanoparticles (SNPs). In vitro dissolution properties of SNPs have been demonstrated and compared with the in vivo pharmacokinetic parameters of rabbit (Oryctolagus cuniculus) serum sample. The present study was also aimed at developing levels of correlation between in vitro and in vivo pharmacokinetic parameters. Cumulative results of the proposed study also suggest good in vitro-in vivo correlation of these novel nanocolloids and suggest their immediate profiling as an antimicrobial drug.
authors.affiliation: Biological Sciences Division, Indian Statistical Institute, 203 B.T. Road, Kolkata 700108, India. Electronic address: samratroychoudhury@gmail.com.
authors.forename: Samrat Roy
authors.initials: SR
authors.lastname: Choudhury
authors.affiliation: Biological Sciences Division, Indian Statistical Institute, 203 B.T. Road, Kolkata 700108, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Basu
authors.affiliation: Division of Bacteriology, National Institute of Cholera and Enteric Diseases, Kolkata 700010, India.
authors.forename: Tanushree
authors.initials: T
authors.lastname: Nag
authors.affiliation: Department of Pharmacy, Jadavpur, Kolkata 7000032, India.
authors.forename: Koushik
authors.initials: K
authors.lastname: Sengupta
authors.affiliation: Himalayan Pharmacy Institute, Sikkim 737136, India.
authors.forename: Manas
authors.initials: M
authors.lastname: Bhowmik
authors.affiliation: Biological Sciences Division, Indian Statistical Institute, 203 B.T. Road, Kolkata 700108, India.
authors.forename: Arunava
authors.initials: A
authors.lastname: Goswami
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D003102:Colloids; D005260:Female; D008954:Models, Biological; D053758:Nanoparticles; D011817:Rabbits; D012995:Solubility; D013457:Sulfur Compounds / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000890:Anti-Infective Agents; D003102:Colloids; D013457:Sulfur Compounds
keywords: In vitro–in vivo pharmacokinetic profiling; Monoclinic; Orthorhombic; Sulfur nanoparticles