title: Synthesis and negative inotropic effects evaluation of 7-substituted-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones.
abstract: A series of 7-alkoxy-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones was synthesized and their negative inotropic effects were evaluated by measuring the left atrium stroke volume in isolated rabbit heart preparations. All compounds moderated the cardiac workload by decreasing heart rate and contractility (inotropic effects). Among them, compound 6 was found to be best potent with a -28.89 ± 1.91 % decrease in the stroke volume at a concentration of 3 × 10(-5) M in our in vitro study.
authors.affiliation: Department of Physiology, College of Basic Medical Sciences, Yanbian University, Yanji, 133000, Jilin, People's Republic of China.
authors.forename: Lan
authors.initials: L
authors.lastname: Hong
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Gong
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Ming-Xia
authors.initials: MX
authors.lastname: Song
authors.forename: Xun
authors.initials: X
authors.lastname: Cui
authors.forename: Zhe-Shan
authors.initials: ZS
authors.lastname: Quan
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D066298:In Vitro Techniques; D015394:Molecular Structure; D009200:Myocardial Contraction / Q000187:drug effects*; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology*; D011817:Rabbits; D013318:Stroke Volume / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D015363:Quinolones