title: MAPT gene rs1052553 variant is not associated with the risk for multiple sclerosis.
abstract: OBJECTIVE
  Some experimental data suggest a possible role of tau protein in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis. The aim of this study was to investigate a possible influence of the SNP rs1052553 in the MAPT gene in the risk for relapsing bout onset (relapsing-remitting and secondary progressive) MS.
  
  
  METHODS
  We analyzed the allelic and genotype frequency of MAPT rs1052553, which has been associated with some neurodegenerative diseases, in 259 patients with relapsing bout onset MS and 291 healthy controls, using TaqMan Assays.
  
  
  RESULTS
  MAPT rs1052553 allelic and genotype frequencies did not differ significantly between relapsing bout onset MS patients and controls, and were unrelated with the age of onset of MS or gender.
  
  
  CONCLUSIONS
  These results suggest that MAPT rs1052553 polymorphism is not related with the risk for relapsing bout onset MS.
authors.affiliation: Department of Pharmacology, University of Extremadura, Cáceres, Spain.
authors.forename: José A G
authors.initials: JA
authors.lastname: Agúndez
authors.forename: Elena
authors.initials: E
authors.lastname: García-Martín
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez
authors.forename: Julián
authors.initials: J
authors.lastname: Benito-León
authors.forename: Jorge
authors.initials: J
authors.lastname: Millán-Pascual
authors.forename: Patricia
authors.initials: P
authors.lastname: Calleja
authors.forename: María
authors.initials: M
authors.lastname: Díaz-Sánchez
authors.forename: Diana
authors.initials: D
authors.lastname: Pisa
authors.forename: Laura
authors.initials: L
authors.lastname: Turpín-Fenoll
authors.forename: Hortensia
authors.initials: H
authors.lastname: Alonso-Navarro
authors.forename: Lucía
authors.initials: L
authors.lastname: Ayuso-Peralta
authors.forename: Dolores
authors.initials: D
authors.lastname: Torrecillas
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Plaza-Nieto
authors.forename: Félix Javier
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
mesh_terms: D000328:Adult; D000483:Alleles; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult; D016875:tau Proteins / Q000235:genetics*
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins
keywords: CSF; GWAS; MAPT; MS; SNP; TNFRSF1A; TPPP/p25; cerebrospinal fluid; genome-wide association studies; microtubule-associated protein tau; multiple sclerosis; single nucleotide polymorphism; tubulin polymerization promoting protein 25; tumor necrosis factor receptor superfamily member 1A