title: Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions.
abstract: Won't let you go! A strategy is described to design small molecules that react with their cellular RNA targets. This approach not only improves the activity of compounds targeting RNA in cell culture by a factor of about 2500 but also enables cell-wide profiling of its RNA targets.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, 3A1, Jupiter, FL 33458 (USA).
authors.forename: Lirui
authors.initials: L
authors.lastname: Guan
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Disney
mesh_terms: D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009696:Nucleic Acids / Q000737:chemistry*; D012313:RNA / Q000737:chemistry* / Q000235:genetics
chemical_list: D009696:Nucleic Acids; D012313:RNA
keywords: RNA; RNA recognition; bioorganic chemistry; chemical biology; nucleic acids
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