title: Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression.
abstract: OBJECTIVE
  To investigation of the histogenesis and the significance of expression of P63 in pulmonary sclerosing hemangioma (SH).
  
  
  METHODS
  Eighteen cases of SH were retrospectively studied, and P63, surfactant protein B (SPB), thyroid transcription factor-1 (TTF-1), epithelial membrane antigen (EMA), cytokeratin (CKpan), vimentin, SMA, chromagranin (CgA), Syn and CD34 were immunohistochemically labelled with EnVision method.
  
  
  RESULTS
  There are mainly four types of structures in SH tissue: solid, papillary, angiomatous (haemorrhagic), and sclerotic pattern. The tumour cells are composed mainly of two types of cells: cuboidal tumour cells and polygonal cells. The immunohistochemistry showed that cuboidal tumour cells expressed P63 (+++) in 16 cases of SH (16/18 cases). Polygonal cells and cuboidal cells of all cases express both TTF-1 and EMA at the same time (18/18 cases); cuboidal tumour cells express SPB (18/18 cases); polygonal tumour cells express vimentin (18/18 cases). In one case, a polygonal tumour cell weakly expressed Chromogranin (CgA) and Syn.
  
  
  CONCLUSIONS
  The P63 positive cuboidal tumour cells may be pluripotent original respiratory epithelial cells, with multidirectional differentiation capacity. Immunohistochemically labelling of P63 may have important value for SH diagnosis.
authors.affiliation: Department of Geriatrics, Huadong Sanatorium, Wuxi, Jiangsu, China.
authors.forename: Jiayu
authors.initials: J
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D047868:Pulmonary Sclerosing Hemangioma / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D008565:Membrane Proteins
keywords: P63; histogenesis; immunohistochemical; pulmonary slerosing hemangioma