title: Epilepsy: new drug targets and neurostimulation.
abstract: Despite advances in the medical and surgical therapy for epilepsy, about 30% of patients do not achieve full seizure control. In the past 5 years new antiepileptic drugs have been approved for clinical use. Some of these drugs have unique, novel mechanisms of action. Overall efficacy of these agents, however, seems similar to other antiepileptic drugs. Vagus nerve stimulation is a well-established palliative therapy for medically resistant epilepsy. Neurostimulation, with newer devices and targets becoming available, is a rapidly expanding field in epileptology. Considerable development and research are still necessary before these newer techniques become the standard of care for the treatment of epilepsy.
authors.affiliation: Department of Neurology, Stritch School of Medicine, Loyola University Chicago, Maguire Center, Suite 2700, 2160 South First Avenue, Maywood, IL 60153, USA. jasconape@lumc.edu
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Asconapé
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D004827:Epilepsy / Q000628:therapy*; D006801:Humans
chemical_list: D000927:Anticonvulsants
keywords: Antiepileptic drugs; Epilepsy; Ezogabine/Retigabine; Lacosamide; Neurostimulation; Perampanel; Retigabine; Rufinamide; Seizures