title: Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents.
abstract: BACKGROUND
  This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats.
  
  
  METHODS
  Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats.
  
  
  RESULTS
  The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P ≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group.
  
  
  CONCLUSIONS
  The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.
authors.affiliation: Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ibadan, Nigeria.
authors.forename: Samuel Adetunji
authors.initials: SA
authors.lastname: Onasanwo
authors.forename: Benjamin Obukowho
authors.initials: BO
authors.lastname: Emikpe
authors.forename: Austin Azubuike
authors.initials: AA
authors.lastname: Ajah
authors.forename: Taiwo Olayemi
authors.initials: TO
authors.lastname: Elufioye
keywords: Anti-ulcer; Musa sapientum; peptic ulcer; ulcer healing
references.citation: J Ethnopharmacol. 2004 Aug;93(2-3):197-206
references.pmid: 15234753
references.citation: Pharmacol Res. 2002 Feb;45(2):155-8
references.pmid: 11846629
references.citation: J Ethnopharmacol. 1995 Jun;46(3):133-52
references.pmid: 7564412
references.citation: Phytomedicine. 2005 May;12(5):345-50
references.pmid: 15957368
references.citation: J Ethnopharmacol. 2001 May;75(2-3):95-115
references.pmid: 11297840
references.citation: Prog Med Chem. 1991;28:201-31
references.pmid: 1843547
references.citation: Scand J Gastroenterol. 1993 Oct;28(10):894-8
references.pmid: 8266018
references.citation: Indian J Exp Biol. 2001 Jul;39(7):719-22
references.pmid: 12019769
references.citation: Am J Dig Dis. 1972 Jul;17(7):619-29
references.pmid: 5032686
references.citation: Pharmacol Res. 1991 Jan;23(1):81-6
references.pmid: 2047362
references.citation: Gastroenterology. 1988 Jan;94(1):10-21
references.pmid: 3335281
references.citation: J Physiol Pharmacol. 1993 Jun;44(2):109-18
references.pmid: 8358048
references.citation: J Ethnopharmacol. 1999 Jun;65(3):283-8
references.pmid: 10404428
references.citation: Virchows Arch A Pathol Anat Histol. 1981;392(2):159-70
references.pmid: 7281506
references.citation: J Ethnopharmacol. 2007 Apr 4;110(3):464-70
references.pmid: 17125945
references.citation: J Ethnopharmacol. 1986 Oct;18(1):33-44
references.pmid: 3821133
references.citation: Eur J Pharmacol. 2002 May 31;444(3):209-15
references.pmid: 12063082
references.citation: Indian J Gastroenterol. 1985 Oct;4(4):249-51
references.pmid: 3850848
references.citation: J Gastroenterol Hepatol. 1994;9 Suppl 1:S60-5
references.pmid: 7881021
references.citation: Dig Dis Sci. 1984 Feb;29(2):141-9
references.pmid: 6697854
references.citation: J Ethnopharmacol. 2007 Sep 5;113(2):252-7
references.pmid: 17629427
references.citation: Phytother Res. 2000 Dec;14(8):581-91
references.pmid: 11113992
references.citation: Cell. 1996 May 3;85(3):331-43
references.pmid: 8616889
references.citation: Phytomedicine. 2001 Mar;8(2):94-100
references.pmid: 11315762
references.citation: Eur J Pharmacol. 1973 May;22(2):191-5
references.pmid: 4514976
references.citation: J Nutr Biochem. 2001 Feb;12(2):95-100
references.pmid: 11182552
references.citation: Am J Med. 1989 Jun 9;86(6A):23-31
references.pmid: 2735333
references.citation: Indian J Exp Biol. 1991 Aug;29(8):701-14
references.pmid: 1769712
references.citation: Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R281-3
references.pmid: 12121837
references.citation: J Ethnopharmacol. 2000 Dec;73(3):423-8
references.pmid: 11090995
references.citation: J Clin Gastroenterol. 1990;12 Suppl 1:S139-47
references.pmid: 2212540
references.citation: Agents Actions. 1982 Apr;12(1-2):247-53
references.pmid: 7080961
references.citation: J Submicrosc Cytol. 1983 Jul;15(3):627-43
references.pmid: 6876219
references.citation: Jpn J Pharmacol. 1991 Dec;57(4):495-505
references.pmid: 1803065
references.citation: J Gastroenterol Hepatol. 1996 Apr;11(4):335-40
references.pmid: 8713699