title: Synthesis of photoreactive phospholipid polymers for use in versatile surface modification of various materials to obtain extreme wettability.
abstract: We synthesized photoreactive phospholipid polymers for use in the versatile surface modification of various materials. The photoreactive methacrylate derivative 2-methacryloyloxyethyl-4-azidobenzoate (MPAz) was synthesized. MPAz was copolymerized with 2-methacryloyloxyethyl phosphorylcholine (MPC) to obtain poly(MPC-co-MPAz) (PMPAz) and with both MPC and n-butyl methacrylate (BMA) to obtain poly(MPC-co-BMA-co-MPAz) (PMBPAz). PMPAz and PMBPAz were bound to the surfaces of various materials, including polymers, glass, and metals, by exposure to ultraviolet irradiation. The azide groups in the MPAz units played a role in the surface anchoring; the polymer was bound covalently to the substrate. After the photoreaction, the surfaces were converted from hydrophobic to superhydrophilic, and their cell adhesion was effectively suppressed.
authors.affiliation: Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Fukazawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
mesh_terms: D000327:Adsorption; D001386:Azides / Q000737:chemistry; D001565:Benzoates / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D002621:Chemistry / Q000379:methods; D006367:HeLa Cells; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D010777:Photochemistry / Q000379:methods; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties; D014867:Water / Q000737:chemistry; D017155:Wettability
chemical_list: D001386:Azides; D001565:Benzoates; D001672:Biocompatible Materials; D008689:Methacrylates; D010743:Phospholipids; D011108:Polymers; D014867:Water; C016284:butyl methacrylate