title: Analysis of related factors affecting prognosis of shunt surgery in patients with secondary normal pressure hydrocephalus.
abstract: OBJECTIVE
  The management of secondary normal pressure hydrocephalus (sNPH) is controversial. Many factors may affect the surgery effect. The purpose of this study was to identify the possible factors influencing prognosis and provide theoretical basis for clinical treatment of sNPH.
  
  
  METHODS
  A retrospective study was carried out to investigate the results of 31 patients with sNPH who underwent ventriculoperitoneal shunt surgery from January 2007 to December 2011. We processed the potential influencing factors by univariate analysis and the result further by multivariate logistic regression analysis.
  
  
  RESULTS
  Factors including age, disease duration and Glasgow coma scale (GCS) score before surgery significantly influenced the prognosis of sNPH (P less than 0.05). Further logistic regression analysis showed that all the three factors are independent influencing factors.
  
  
  CONCLUSIONS
  Age, disease duration and GCS score before surgery have positive predictive value in estimating favorable response to surgical treatment for sNPH.
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Hang-gen
authors.initials: HG
authors.lastname: Du
authors.forename: Li-chun
authors.initials: LC
authors.lastname: Yin
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.forename: Guo-jun
authors.initials: GJ
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Tian
authors.forename: Bi-lie
authors.initials: BL
authors.lastname: Hao
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D017287:Ventriculoperitoneal Shunt