title: Measurement of baseline toxicity and QSAR analysis of 50 non-polar and 58 polar narcotic chemicals for the alga Pseudokirchneriella subcapitata.
abstract: In this paper a set of homogenous experimental algal toxicity data was measured for 50 non-polar narcotic chemicals using the alga Pseudokirchneriella subcapitata in a closed test with a growth rate endpoint. Most of the tested compounds are high volume industrial chemicals that so far lacked published REACH-compliant algal growth inhibition values. The test protocol fulfilled the criteria set forth in the OECD guideline 201 and had the same sensitivity as the open test which allowed direct comparison of toxicity values. Baseline QSAR model for non-polar narcotic compounds was established and compared with previous analogous models. Multi-linear QSAR model was derived for the non-polar and 58 previously tested polar (anilines and phenols) narcotic compounds modulating hydrophobicity, molecular size, electronic and molecular stability effects coded in the molecular descriptors. Descriptors in the model were analyzed and applicability domain was assessed providing further guidelines for the in silico prediction purposes in decision support while performing risk assessment. QSAR models in the manuscript are available on-line through QsarDB repository for exploring and prediction services (http://hdl.handle.net/10967/106).
authors.affiliation: Laboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia. Electronic address: villem.aruoja@kbfi.ee.
authors.forename: Villem
authors.initials: V
authors.lastname: Aruoja
authors.forename: Maikki
authors.initials: M
authors.lastname: Moosus
authors.forename: Anne
authors.initials: A
authors.lastname: Kahru
authors.forename: Mariliis
authors.initials: M
authors.lastname: Sihtmäe
authors.forename: Uko
authors.initials: U
authors.lastname: Maran
mesh_terms: D000814:Aniline Compounds; D000460:Chlorophyta / Q000187:drug effects* / Q000502:physiology; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D009294:Narcotics / Q000737:chemistry* / Q000592:standards / Q000633:toxicity; D010636:Phenols / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D018675:Toxicity Tests
chemical_list: D000814:Aniline Compounds; D009294:Narcotics; D010636:Phenols; C023650:aniline
keywords: Algae; Baseline toxicity; Non-polar narcosis; Pseudokirchneriella subcapitata; QSAR; REACH