title: The efficacy of nardostachys jatamansi against the radiation induced haematological damage in rats.
abstract: BACKGROUND
  Radiation is increasingly being used for medical purposes and it is an established weapon in the diagnosis and the therapy of cancer. An exposure to 1-2 Gys causes the NVD (Nausea, vomiting, diarrhoea) syndrome, whereas an exposure to 2-6 Gys causes the haematopoietic syndrome. The aim of the present study was to investigate the protective effect of the Nardostachys jatamansi root extract (NJE) on the radiation induced haematological damage in rats.
  
  
  METHODS
  EBR was performed at the Microtron Centre, Mangalore University, India. Rats were treated with NJE once daily for 15 days before and after the irradiation. After the irradiation, blood was collected for determining the peripheral blood counts (RBC and WBC), haemoglobin, the platelet count and the packed cell volume (PCV) at 6 hours, 12 hours, 24 hours, 48 hours and 5, 10 and 15 days post irradiation. The data was analyzed by one way ANOVA, followed by the Tukey's test for multiple comparisons.
  
  
  RESULTS
  NJE provided protection against the radiation induced haematological disorders. The rats treated with NJE exhibited a time dependent significant elevation in all the haematological parameters which were studied and its modulation upto the near normal level was recorded.
  
  
  CONCLUSIONS
  From this study, we concluded that, NJE provides protection by modulating the radiation induced damage on the haematopoietic system.
authors.affiliation: Lecturer, Department of Physiology, K.S.Hegde Medical Academy , Nitte University, Karnataka-575018, India .
authors.forename: Damodara K M
authors.initials: DK
authors.lastname: Gowda
authors.forename: Lathika
authors.initials: L
authors.lastname: Shetty
authors.forename: Krishna
authors.initials: K
authors.lastname: A P
authors.forename: Suchetha N
authors.initials: SN
authors.lastname: Kumari
authors.forename: Ganesh
authors.initials: G
authors.lastname: Sanjeev
authors.forename: Naveen
authors.initials: N
authors.lastname: P
keywords: CFU Assay; Electron beam irradiation; Packed cell volume; Peripheral blood counts; Platelet count; Splenic index; Whole body irradiation
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