title: Enterotoxigenic Escherichia coli: Orchestrated host engagement.
abstract: The enterotoxigenic Escherichia coli are a pervasive cause of serious diarrheal illness in developing countries. Presently, there is no vaccine to prevent these infections, and many features of the basic pathogenesis of these organisms remain poorly understood. Until very recently most pathogenesis studies had focused almost exclusively on a small subset of known "classical" virulence genes, namely fimbrial colonization factors and the heat-labile (LT) and heat stable (ST) enterotoxins. However, recent investigations of pathogen-host interactions reveal a surprisingly complex and intricately orchestrated engagement involving the interplay of classical and "novel" virulence genes, as well as participation of genes highly conserved in the E. coli species. These studies may inform further rational approaches to vaccine development for these important pathogens.
authors.affiliation: Department of Medicine; Washington University School of Medicine; St. Louis, MO USA; Medicine Service; Veterans Affairs Medical Center; St. Louis, MO USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Fleckenstein
authors.affiliation: Department of Microbiology and Immunology; University of Miami; Miller School of Medicine; Miami, FL USA.
authors.forename: George M
authors.initials: GM
authors.lastname: Munson
authors.affiliation: Department of Microbiology and Immunology; University of Maryland School of Medicine; Baltimore, MD USA; Institute for Genome Sciences; University of Maryland School of Medicine; Baltimore, MD USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Rasko
mesh_terms: D054307:Enterotoxigenic Escherichia coli / Q000235:genetics* / Q000472:pathogenicity*; D004847:Epithelial Cells / Q000276:immunology* / Q000382:microbiology*; D006801:Humans
keywords: Escherichia coli vaccines; adhesins; bacterial; enterotoxigenic Escherichia coli; gene expression profiling; host-pathogen interaction; transcriptome
references.citation: Nature. 2009 Jan 29;457(7229):594-8
references.pmid: 19060885
references.citation: Infect Immun. 1983 Feb;39(2):889-97
references.pmid: 6131869
references.citation: Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):547-52
references.pmid: 15647345
references.citation: Infect Immun. 2012 Aug;80(8):2791-801
references.pmid: 22645287
references.citation: J Bacteriol. 2008 Oct;190(20):6881-93
references.pmid: 18676672
references.citation: Vaccine. 2011 Aug 26;29(37):6167-78
references.pmid: 21723899
references.citation: J Biol Chem. 2003 May 16;278(20):17664-71
references.pmid: 12637526
references.citation: Nat Biotechnol. 2002 Sep;20(9):914-21
references.pmid: 12172557
references.citation: Expert Rev Vaccines. 2012 Apr;11(4):495-507
references.pmid: 22551034
references.citation: Cell Host Microbe. 2011 Aug 18;10(2):165-74
references.pmid: 21843873
references.citation: Vaccine. 2009 Jul 23;27(34):4601-8
references.pmid: 19523914
references.citation: Infect Immun. 2011 Feb;79(2):950-60
references.pmid: 21078854
references.citation: J Bacteriol. 2009 Jan;191(1):178-86
references.pmid: 18978047
references.citation: Infect Immun. 2010 Jul;78(7):3027-35
references.pmid: 20457787
references.citation: Mol Microbiol. 1995 Oct;18(2):237-45
references.pmid: 8709843
references.citation: Clin Vaccine Immunol. 2011 Dec;18(12):2128-35
references.pmid: 21994355
references.citation: Cell Microbiol. 2006 Sep;8(9):1516-27
references.pmid: 16922869
references.citation: Lancet. 2003 Jul 26;362(9380):286-91
references.pmid: 12892959
references.citation: Microb Pathog. 1998 Sep;25(3):111-20
references.pmid: 9790870
references.citation: Clin Infect Dis. 2012 Jun;54(11):1615-7
references.pmid: 22437237
references.citation: Gastroenterology. 1984 Oct;87(4):934-40
references.pmid: 6381216
references.citation: J Infect Dis. 1998 Mar;177(3):662-7
references.pmid: 9498445
references.citation: J Clin Microbiol. 2011 Sep;49(9):3198-203
references.pmid: 21775541
references.citation: Infect Immun. 2013 Jan;81(1):259-70
references.pmid: 23115039
references.citation: Infect Immun. 2006 Apr;74(4):2245-58
references.pmid: 16552055
references.citation: Clin Vaccine Immunol. 2012 Dec;19(12):1921-31
references.pmid: 23035175
references.citation: J Biol Chem. 2011 Aug 26;286(34):29771-9
references.pmid: 21757737
references.citation: Infect Immun. 2012 Mar;80(3):1232-42
references.pmid: 22215741
references.citation: J Clin Microbiol. 1999 Sep;37(9):2974-8
references.pmid: 10449484
references.citation: Curr Opin Microbiol. 2010 Oct;13(5):619-24
references.pmid: 20888288
references.citation: Clin Vaccine Immunol. 2012 Oct;19(10):1603-8
references.pmid: 22875600
references.citation: Infect Immun. 1979 Mar;23(3):729-36
references.pmid: 378834
references.citation: Infect Immun. 2009 Feb;77(2):791-8
references.pmid: 19075028
references.citation: J Biol Chem. 2007 Aug 17;282(33):23970-80
references.pmid: 17569668
references.citation: Clin Vaccine Immunol. 2010 Jul;17(7):1055-65
references.pmid: 20463105
references.citation: J Bacteriol. 2011 Mar;193(6):1369-76
references.pmid: 21216994
references.citation: Infect Immun. 2006 Feb;74(2):869-75
references.pmid: 16428729
references.citation: Scand J Infect Dis Suppl. 1982;33:83-95
references.pmid: 6127806
references.citation: Proc Natl Acad Sci U S A. 2002 May 14;99(10):7066-71
references.pmid: 12011463
references.citation: Am J Epidemiol. 1990 May;131(5):886-904
references.pmid: 2157338
references.citation: Clin Vaccine Immunol. 2011 Nov;18(11):1803-8
references.pmid: 21900530
references.citation: Microbes Infect. 2010 Feb;12(2):89-98
references.pmid: 19883790
references.citation: Infect Immun. 2004 Mar;72(3):1786-94
references.pmid: 14977988
references.citation: Infect Immun. 2008 May;76(5):2106-12
references.pmid: 18285493
references.citation: Infect Immun. 2007 Aug;75(8):3961-8
references.pmid: 17548483