title: Environmental pollution effects on reproductive health - clinical-epidemiological study in southern Italy.
abstract: This study aims to address the clinical, statistical and Epidemiological Relationship Between Birth Defects and Environmental Pollution, in the Campania Region and in Salerno.
  
  
  OBJECTIVE
  WE EXAMINED FOUR GROUPS OF SUBJECTS AS FOLLOWS: a sample of pregnant women living in Salerno, a sample of pregnant women living in highly polluted areas, a sample of controls, pregnant women and residents out of the Campania Region, considered in unpolluted areas (Foggia) and in the Salerno area.
  
  
  METHODS
  a toxicological and genetic analysis was conducted on patients examined.
  
  
  CONCLUSIONS
  there is an epidemiological link between environmental pollution and reproductive health in the Salerno area. Experimentally there are the first evidences of endocrine disruptors by the PCB. It has been inferred an overexpression of the mir-191 as a marker of pollution by dioxin-like compounds. Socially, correct information of populations at risk is necessary and a possible preventive and ongoing medical care must be ensured.
authors.affiliation: Department of Gynecology and Obstetrics, University of Salerno, Salerno, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Marra
authors.forename: F
authors.initials: F
authors.lastname: Zullo
authors.forename: B
authors.initials: B
authors.lastname: De Felice
authors.forename: L
authors.initials: L
authors.lastname: Nappi
authors.forename: M
authors.initials: M
authors.lastname: Guida
authors.forename: M
authors.initials: M
authors.lastname: Trifuoggi
authors.forename: C
authors.initials: C
authors.lastname: Nappi
authors.forename: A
authors.initials: A
authors.lastname: Di Spiezio Sardo
authors.forename: B
authors.initials: B
authors.lastname: Zizolfi
authors.forename: G
authors.initials: G
authors.lastname: Capece
authors.forename: F
authors.initials: F
authors.lastname: Visconti
authors.forename: J
authors.initials: J
authors.lastname: Troisi
authors.forename: C
authors.initials: C
authors.lastname: Ciccone
authors.forename: M
authors.initials: M
authors.lastname: Guida
references.citation: Chemosphere. 2009 Aug;76(6):747-54
references.pmid: 19539348
references.citation: Occup Environ Med. 2004 Jan;61(1):8-15
references.pmid: 14691267
references.citation: Environ Health. 2009 Dec 23;8:60
references.pmid: 20030820
references.citation: Epidemiol Prev. 2004 Nov-Dec;28(6):311-21
references.pmid: 15792153
references.citation: Environ Health Perspect. 1992 Nov;98:167-78
references.pmid: 1486846
references.citation: Ann Ist Super Sanita. 2008;44(1):99-111
references.pmid: 18469382
references.citation: Occup Environ Med. 2009 Nov;66(11):725-32
references.pmid: 19416805
references.citation: Environ Res. 2007 Oct;105(2):247-55
references.pmid: 17239850
references.citation: Bull Environ Contam Toxicol. 1994 Jan;52(1):13-8
references.pmid: 8130408
references.citation: Environ Sci Pollut Res Int. 2006 May;13(3):184-91
references.pmid: 16758709
references.citation: Ann Ist Super Sanita. 2010;46(3):293-8
references.pmid: 20847464
references.citation: Cancer Biol Ther. 2011 Jul 15;12(2):106-11
references.pmid: 21734464
references.citation: Mutat Res. 2008 Jul-Aug;659(1-2):158-65
references.pmid: 18342568
references.citation: Environ Health Perspect. 1983 Apr;50:233-45
references.pmid: 6873017