title: Association of putative members to family of mosquito odorant binding proteins: scoring scheme using fuzzy functional templates and cys residue positions.
abstract: Proteins may be related to each other very specifically as homologous subfamilies. Proteins can also be related to diverse proteins at the super family level. It has become highly important to characterize the existing sequence databases by their signatures to facilitate the function annotation of newly added sequences. The algorithm described here uses a scheme for the classification of odorant binding proteins on the basis of functional residues and Cys-pairing. The cysteine-based scoring scheme not only helps in unambiguously identifying families like odorant binding proteins (OBPs), but also aids in their classification at the subfamily level with reliable accuracy. The algorithm was also applied to yet another cysteine-rich family, where similar accuracy was observed that ensures the application of the protocol to other families.
authors.affiliation: Université de La Reunion, DSIMB, INSERM UMR-S 665, La Reunion, France. ; National Centre for Biological Sciences, Tata Institute for Fundamental Research, GKVK campus, Bangalore, INDIA. ; Manipal University, Madhav Nagar, Manipal, Karnataka, India.
authors.forename: Malini
authors.initials: M
authors.lastname: Manoharan
authors.forename: Kannan
authors.initials: K
authors.lastname: Sankar
authors.forename: Bernard
authors.initials: B
authors.lastname: Offmann
authors.forename: Sowdhamini
authors.initials: S
authors.lastname: Ramanathan
keywords: Classification of proteins; Functionally important residues; Ligand binding residues; cysteine-based scoring scheme
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