title: Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene.
abstract: We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and was submitted to an allogeneic bonemarrow transplantation. Fifty-three days after the procedure, he died due to acute graft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in only five patients in the whole world, with three clinical presentations: myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloid leukemia.
authors.affiliation: Instituto HEMOMED, SP, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Bellesso
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Santucci
authors.forename: Daniela Ferreira
authors.initials: DF
authors.lastname: Dias
authors.forename: Renato
authors.initials: R
authors.lastname: Centrone
authors.forename: Renata Campos
authors.initials: RC
authors.lastname: Elias
keywords: Leukemia, myeloid, chronic, atypical, BCR-ABL negative; Myelodysplastic-myeloproliferative diseases; Proto-oncogene proteins c-bcr
references.citation: Genes Chromosomes Cancer. 2001 Dec;32(4):302-10
references.pmid: 11746971
references.citation: Hum Mol Genet. 2002 Jun 1;11(12):1391-7
references.pmid: 12023981
references.citation: Br J Haematol. 2008 Aug;142(4):503
references.pmid: 18537978
references.citation: Mol Cytogenet. 2012 May 01;5(1):23
references.pmid: 22549126
references.citation: Blood. 2001 Dec 15;98(13):3778-83
references.pmid: 11739186
references.citation: Leuk Res. 2010 Dec;34(12):1674-6
references.pmid: 20594592
references.citation: PLoS One. 2012;7(2):e32451
references.pmid: 22384256
references.citation: Cancer Genet Cytogenet. 2008 Jun;183(2):105-8
references.pmid: 18503828
references.citation: Genes Chromosomes Cancer. 2005 Nov;44(3):329-33
references.pmid: 16001431