title: Effect of single-dose methotrexate on ovarian reserve in women with ectopic pregnancy.
abstract: OBJECTIVE
  To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Women's health education and research hospital.
  
  
  METHODS
  Eighty-two patients with ectopic pregnancy and 80 healthy women in the same age group were included in the study. Of the 82 patients, 49 with ectopic pregnancy were treated with single-dose systemic methotrexate (MTX) and 33 were treated surgically with laparoscopy or laparotomy (salpingectomy or salpingostomy).
  
  
  METHODS
  Ovarian reserve testing.
  
  
  METHODS
  Basal FSH on the 3rd day of the menstrual cycle, E₂, basal antral follicle count (AFC), and ovarian volume.
  
  
  RESULTS
  There were no differences among the groups in terms of basal FSH, E₂, AFC, and ovarian volume.
  
  
  CONCLUSIONS
  The single-dose MTX treatment had no effect on ovarian reserve in women with ectopic pregnancy as measured by the above-mentioned parameters.
authors.affiliation: Aegean Obstetrics and Gynecology Education and Research Hospital, İzmir, Turkey. Electronic address: iuyar03@yahoo.com.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Uyar
authors.forename: Onur Umut
authors.initials: OU
authors.lastname: Yucel
authors.forename: Cenk
authors.initials: C
authors.lastname: Gezer
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Gulhan
authors.forename: Buket
authors.initials: B
authors.lastname: Karis
authors.forename: H Merih
authors.initials: HM
authors.lastname: Hanhan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozeren
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D010053:Ovary / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000175:diagnosis*; D011446:Prospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D004958:Estradiol; D008727:Methotrexate
keywords: Ovarian reserve; ectopic pregnancy; methotrexate treatment