title: Leukocyte telomere length in mastocytosis: correlations with depression and perceived stress.
abstract: BACKGROUND
  Mastocytosisis a rare disease associated with chronic symptoms related to mast cell mediator release. Patients with mastocytosis display high level of negative emotionality such as depression and stress sensibility. Brain mast cells are mainly localized in the diencephalon, which is linked to emotion regulatory systems. Negative emotionality has been shown to be associated with telomere shortening. Taken together these observations led us to hypothesize that mast cells activity could be involved in both negative emotionality and telomere shortening in mastocytosis.
  
  
  OBJECTIVE
  To demonstrate a possible relationship between negative emotionality in mastocytosis and leukocytes telomere length.
  
  
  METHODS
  Leukocyte telomere length and telomerase activity were measured among mastocytosis patients and were correlated with perceived stress and depression assessed by the Beck Depression Inventory revised and the Perceived Stress Scale.
  
  
  RESULTS
  Mild-severe depression scores were frequent (78.9%) as well as high perceived stress (42.11%). Telomere length was correlated to perceived stress (r=0.77; p=0.0001) but not to depression in our population. Patients displaying Wild-type KIT significantly presented higher perceived stress levels. Patients with the D816VC KIT mutation who had high perceived stress scores displayed significantly shorter telomere but not if they had high depression scores.
  
  
  CONCLUSIONS
  These findings suggest that high perceived stress in mastocytosis could accelerate the rate of leukocytes telomere shortening. Since mastocytosis is, by definition, a mast cell mediated disease; these cells could be involved in this phenomenon. Mechanistic causal relationships between these parameters need to be investigated.
authors.affiliation: Centre de référence des mastocytoses, Université Paris Descartes, Sorbonne, Paris Cité, Hôpital Necker Enfants malades, Paris, France; Institut Imagine Université Paris Descartes, Sorbonne, Paris Cité, Hôpital Necker Enfants malades, Paris, France; CNRS UMR 8147, Hôpital Necker-Enfants malades, 149 rue des Sèvres, 75743 Paris Cedex 15, France. Electronic address: sophie.georgin-lavialle@tnn.aphp.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Georgin-Lavialle
authors.forename: Daniela Silva
authors.initials: DS
authors.lastname: Moura
authors.forename: Julie
authors.initials: J
authors.lastname: Bruneau
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Chauvet-Gélinier
authors.forename: Gandhi
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authors.lastname: Damaj
authors.forename: Erinn
authors.initials: E
authors.lastname: Soucie
authors.forename: Stéphane
authors.initials: S
authors.lastname: Barete
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Gacon
authors.forename: Catherine
authors.initials: C
authors.lastname: Grandpeix-Guyodo
authors.forename: Felipe
authors.initials: F
authors.lastname: Suarez
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Launay
authors.forename: Isabelle
authors.initials: I
authors.lastname: Durieu
authors.forename: Aurélie
authors.initials: A
authors.lastname: Esparcieux
authors.forename: Isabelle
authors.initials: I
authors.lastname: Guichard
authors.forename: Agnès
authors.initials: A
authors.lastname: Sparsa
authors.forename: Franck
authors.initials: F
authors.lastname: Nicolini
authors.forename: Christian de
authors.initials: Cd
authors.lastname: Gennes
authors.forename: Benoit
authors.initials: B
authors.lastname: Trojak
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Haffen
authors.forename: Pierre
authors.initials: P
authors.lastname: Vandel
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.forename: Patrice
authors.initials: P
authors.lastname: Dubreuil
authors.forename: Bernard
authors.initials: B
authors.lastname: Bonin
authors.forename: Serge
authors.initials: S
authors.lastname: Sultan
authors.forename: Jean-Raymond
authors.initials: JR
authors.lastname: Teyssier
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000235:genetics*; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008415:Mastocytosis / Q000235:genetics* / Q000523:psychology*; D008875:Middle Aged; D013315:Stress, Psychological / Q000235:genetics*; D059506:Telomere Shortening; D055815:Young Adult
keywords: CT; Cellular aging; Depression; Mast cell; Mastocytosis; Negative emotionality; PBMC; Perceived stress; RTA; Telomerase activity; Telomere length; control; peripheral blood mononuclear cells; relative telomerase activity