title: Clinical factors that predict noncirrhotic portal hypertension in HIV-infected patients: a proposed diagnostic algorithm.
abstract: Noncirrhotic portal hypertension (NCPH) is a rare but important clinical entity in human immunodeficiency virus (HIV) populations. The purpose of this study was to describe the clinical factors associated with the condition in an effort to formulate a diagnostic algorithm for easy and early diagnosis. We performed a multicenter, retrospective case-control study of 34 patients with NCPH and 68 control HIV patients. The study found that thrombocytopenia, splenomegaly, didanosine use, elevated aminotransferases, and an elevated alkaline phosphatase level were all significantly more prevalent in the NCPH cohort. Using these easily available clinical parameters, we developed an algorithm for early diagnosis of NCPH in HIV.
authors.affiliation: Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Parikh
authors.forename: Valerie
authors.initials: V
authors.lastname: Martel-Laferriere
authors.forename: Tatyana
authors.initials: T
authors.lastname: Kushner
authors.forename: Kate
authors.initials: K
authors.lastname: Childs
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Vachon
authors.forename: Deepti
authors.initials: D
authors.lastname: Dronamraju
authors.forename: Chris
authors.initials: C
authors.lastname: Taylor
authors.forename: Maria-Isabel
authors.initials: MI
authors.lastname: Fiel
authors.forename: Thomas
authors.initials: T
authors.lastname: Schiano
authors.forename: Mark
authors.initials: M
authors.lastname: Nelson
authors.forename: Kosh
authors.initials: K
authors.lastname: Agarwal
authors.forename: Douglas T
authors.initials: DT
authors.lastname: Dieterich
mesh_terms: D000328:Adult; D000465:Algorithms; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
keywords: HIV; didanosine; esophageal variceal bleeding; liver disease; noncirrhotic portal hypertension; portal hypertension; splenomegaly; thrombocytopenia