title: Colorectal tissue engineering: prerequisites, current status and perspectives.
abstract: Gastrointestinal tissue engineering has emerged over the past 20 years and was often focused on esophagus, stomach or small intestine, whereas bioengineering researches of colorectal tissue are scarce. However, some promising results have been obtained in animal models. Refinements should be performed in scaffold and cell source selection to allow smooth muscle layer regeneration. Indeed, synthetic and natural polymers such as small intestinal submucosa and collagen sponge seeded with organoid units or smooth muscle cells did not allow smooth muscle regeneration. Mesenchymal stem cells derived from adipose tissue seeded on composite scaffold could represent an interesting way to achieve this goal. This article reviews potential indications, current status and perspectives of tissue engineering in the area of colorectal surgery.
authors.affiliation: CHU de Bordeaux, Département de Chirurgie Viscérale, F-33000 Bordeaux, France. quentin.denost@chu-bordeaux.fr
authors.forename: Quentin
authors.initials: Q
authors.lastname: Denost
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Adam
authors.forename: Eric
authors.initials: E
authors.lastname: Rullier
authors.forename: Reine
authors.initials: R
authors.lastname: Bareille
authors.forename: Alexandra
authors.initials: A
authors.lastname: Montembault
authors.forename: Laurent
authors.initials: L
authors.lastname: David
authors.forename: Laurence
authors.initials: L
authors.lastname: Bordenave
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism; D000818:Animals; D001705:Bioprosthesis; D003106:Colon; D004195:Disease Models, Animal; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D009130:Muscle, Smooth / Q000166:cytology / Q000378:metabolism; D012007:Rectum; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends*; D054457:Tissue Scaffolds