title: Plasma selenium status in a group of Australian blood donors and fresh blood components.
abstract: The purpose of this study was to assess plasma selenium levels in an Australian blood donor population and measure extra-cellular selenium levels in fresh manufactured blood components. Selenium levels were measured using graphite furnace atomic absorption spectrometry with Zeeman background correction. The mean plasma selenium level in healthy plasmapharesis donors was 85.6±0.5 μg/L and a regional difference was observed between donors in South East Queensland and Far North Queensland. Although participants had selenium levels within the normal range (55.3-110.5 μg/L), 88.5% had levels below 100 μg/L, a level that has been associated with sub-optimal activity of the antioxidant enzyme glutathione peroxidase (GPx). Extra-cellular selenium levels in clinical fresh frozen plasma (cFFP) and apheresis-derived platelets (APH Plt) were within the normal range. Packed red blood cells (PRBC) and pooled buffy coat-derived platelets (BC Plt) had levels at the lower limit of detection, which may have clinical implications to the massively transfused patient.
authors.affiliation: Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia. Electronic address: charles_mcdonald@health.qld.gov.au.
authors.forename: Charles
authors.initials: C
authors.lastname: McDonald
authors.forename: Kathryn
authors.initials: K
authors.lastname: Colebourne
authors.forename: Helen M
authors.initials: HM
authors.lastname: Faddy
authors.forename: Robert
authors.initials: R
authors.lastname: Flower
authors.forename: John F
authors.initials: JF
authors.lastname: Fraser
mesh_terms: D001315:Australia; D001782:Blood Donors; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D012643:Selenium / Q000097:blood*
chemical_list: D012643:Selenium
keywords: Blood donors; Plasmapharesis; Selenium; Transfusion