title: Changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010.
abstract: Shigella species are a common cause of acute diarrheal disease in China. In this study, we characterized the changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010. A total of 5999 Shigella strains were isolated and serotyped from the 302nd Hospital in Beijing. The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010. S. flexneri 2a and S. sonnei were the most frequently isolated Shigella, with their respective isolates making up 53.3% and 27.6% of the total. Isolates of S. flexneri 4c, 4a, and x made up 3% respectively of the total isolates. Significant decreases in percentage of S. flexneri over time were observed. S. sonnei surpassed S. flexneri 2a as the predominant serotype in 2000. Most isolates were recovered from July to September; 13.6% of the isolates were recovered from children aged 0 to 5 years, and 16% were recovered from those aged 21 to 25 years. S. flexneri 2a and 5 were recovered mostly from males (33.41%, p < 0.001; and 0.46%, p < 0.001%; respectively), whereas S. flexneri 2b and 6, and S. sonnei were most often isolated from females. Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period. The emergence of S. sonnei and the overall decreasing isolation rate of Shigella in Beijing can potentially aid in the development of vaccine and control strategies for shigellosis in the city.
authors.affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.
authors.forename: Enbo
authors.initials: E
authors.lastname: Cui
authors.affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Bao
authors.affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.
authors.forename: Zhenhong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.
authors.forename: Suming
authors.initials: S
authors.lastname: Chen
authors.affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.
authors.forename: Juling
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.
authors.forename: Chenglong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zou
authors.affiliation: School of Basic Medical Sciences, Peking University, Beijing 100083, PR China.
authors.forename: John D
authors.initials: JD
authors.lastname: Klena
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.
authors.forename: Fen
authors.initials: F
authors.lastname: Qu
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Wang
keywords: Beijing hospital; Serotype; Shigella; Shigellosis
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