title: Canine serum C-reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery.
abstract: BACKGROUND
  C-reactive protein (CRP) is an established serum marker for the presence of systemic inflammation in dogs. Results from previous experimental and clinical studies suggest that CRP concentrations also quantitatively reflect the degree and progress of an inflammatory process, suggesting its use for inflammation monitoring.
  
  
  OBJECTIVE
  The objective was to investigate whether the canine CRP response in serum correlates with the amount of trauma and the consequent inflammatory response after 3 standard aseptic soft-tissue surgical procedures in 3 groups of dogs.
  
  
  METHODS
  A total of 24 client-owned intact female dogs of various breeds were enrolled in a clinical study with random allocation into 2 surgical groups, for either conventional, open-approach ovariohysterectomy (OVH; n = 14) or laparoscopic assisted OVH (n = 10). In addition, a group of 8 male Beagles from a laboratory animal facility underwent vasectomy, serving as the third and mildest surgical trauma group. Serum CRP was measured pre- and at 4, 8, 12, 23, and 27 hours postsurgery. Cumulative concentration over time and point concentrations of CRP were correlated with the surgical trauma impact level.
  
  
  RESULTS
  There was a significant surgery trauma-related difference in cumulative CRP concentrations among the 3 groups, and also in the 12 hours postsurgery concentration.
  
  
  CONCLUSIONS
  The CRP response varied according to the degree of surgical trauma on 3 standardized levels, thus supporting the use of canine serum concentrations of CRP as an inflammatory activity indicator and monitoring marker.
authors.affiliation: Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
authors.forename: Mads
authors.initials: M
authors.lastname: Kjelgaard-Hansen
authors.forename: Henriette
authors.initials: H
authors.lastname: Strom
authors.forename: Lars F
authors.initials: LF
authors.lastname: Mikkelsen
authors.forename: Thomas
authors.initials: T
authors.lastname: Eriksen
authors.forename: Asger L
authors.initials: AL
authors.lastname: Jensen
authors.forename: Michael
authors.initials: M
authors.lastname: Luntang-Jensen
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D004285:Dogs; D017558:Elective Surgical Procedures / Q000009:adverse effects / Q000662:veterinary; D005260:Female; D008297:Male; D011183:Postoperative Complications / Q000097:blood / Q000662:veterinary*; D011897:Random Allocation; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000662:veterinary*
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Acute phase protein; acute phase reaction; controlled tissue trauma; postsurgical monitoring