title: Multiple strategies to activate gold nanoparticles as antibiotics.
abstract: Widespread antibiotic resistance calls for new strategies. Nanotechnology provides a chance to overcome antibiotic resistance by multiple antibiotic mechanisms. This paper reviews the progress in activating gold nanoparticles with nonantibiotic or antibiotic molecules to combat bacterial resistance, analyzes the gap between experimental achievements and real clinical application, and suggests some potential directions in developing antibacterial nanodrugs.
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, 100190, Beijing, China.
authors.forename: Yuyun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xingyu
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy; D004337:Drug Carriers / Q000737:chemistry; D004352:Drug Resistance, Microbial / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D050997:Nanomedicine
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D006046:Gold