title: Elevated serum angiopoietin-like protein 6 in women with subsequent pregnancy-induced hypertension: a preliminary study.
abstract: OBJECTIVE
  Association of maternal angiopoietin-like protein 6 (Angptl6) levels with subsequent development of pregnancy-induced hypertension (PIH).
  
  
  METHODS
  At 24 and 32 weeks of gestation in 47 relatively overweight (BMI ≥ 24 kg/m(2)), nulliparous pregnant women serum concentrations of Angptl6 were quantified prospectively. Insulin sensitivity and lipids were measured at 24 weeks.
  
  
  RESULTS
  Angptl6 levels at 24 weeks, but not at 32 weeks, were significantly higher in women with subsequent PIH. Metabolic factors at 24 weeks did not correlate with Angptl6 levels.
  
  
  CONCLUSIONS
  This preliminary study suggests that in the second trimester, Angptl6 levels are higher in women with subsequent PIH.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital District of Helsinki and Uusimaa, Helsinki, Finland.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Tuuri
authors.forename: Matti S
authors.initials: MS
authors.lastname: Jauhiainen
authors.forename: Christian P
authors.initials: CP
authors.lastname: Ehnholm
authors.forename: Matti J
authors.initials: MJ
authors.lastname: Tikkanen
authors.forename: M Gary
authors.initials: MG
authors.lastname: Nicholls
authors.forename: Risto J
authors.initials: RJ
authors.lastname: Kaaja
mesh_terms: D000328:Adult; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D009765:Obesity / Q000150:complications; D010298:Parity; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D013564:Sympathetic Nervous System / Q000502:physiology
chemical_list: C477601:ANGPTL6 protein, human; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D015415:Biomarkers; D054439:Ghrelin; D008055:Lipids; D004837:Epinephrine