title: Short-term use of liraglutide in the management of patients with weight regain after bariatric surgery.
abstract: OBJECTIVE
  To evaluate the results of the use of liraglutide in a group of patients undergoing surgical treatment of morbid obesity with unsatisfactory weight loss or regain of more than 15% of minimum reached weight.
  
  
  METHODS
  The authors conducted a retrospective analysis of 15 operated patients who had excess weight loss <50% after two years of follow-up or regained weight more than 15% of the minimum reached weight. We included only patients who had the expected "surgical anatomy", assessed by contrast radiography and endoscopy. Mean age was 47.2 ± 12.5 years, and patients received liraglutide at doses from 1.2 to 3.0 mg/day for eight to 28 weeks follow-up.
  
  
  RESULTS
  Surgical treatment induced a weight loss of 34.1 ± 16.5 kg. The average weight regain after 5.3 ± 3.3 years was 14.2 ± 12.1 Kg. The average weight was significantly reduced after treatment with liraglutide (100.9 ± 18.3 kg. vs Kg 93.5 ± 17.4, p <0.0001). Six patients had nausea and two discontinued therapy due to the cost of medication.
  
  
  CONCLUSIONS
  medical treatment directed to the control of satiety using liraglutide may be an alternative treatment of patients with poor weight loss or weight regain after surgery when no technical problem has been identified.
authors.affiliation: Service of Metabolic and Bariatric Surgery, Department of Digestive Surgery, Clinics Hospital, São Paulo University - HC/FM/USP, city of São Paulo, São Paulo State - SP, Brazil. pajecki@netpoint.com.br
authors.forename: Denis
authors.initials: D
authors.lastname: Pajecki
authors.forename: Alfredo
authors.initials: A
authors.lastname: Halpern
authors.forename: Cintia
authors.initials: C
authors.lastname: Cercato
authors.forename: Marcio
authors.initials: M
authors.lastname: Mancini
authors.forename: Roberto
authors.initials: R
authors.lastname: de Cleva
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Santo
mesh_terms: D050110:Bariatric Surgery; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D000069450:Liraglutide; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery*; D012189:Retrospective Studies; D013997:Time Factors; D017211:Treatment Failure; D015430:Weight Gain
chemical_list: D000069450:Liraglutide; D052216:Glucagon-Like Peptide 1