title: Infection with Toxoplasma gondii does not elicit predator aversion in male mice nor increase their attractiveness in terms of mate choice.
abstract: Behavioral manipulation hypothesis posits that some parasites induce behavioral changes in the host to increase transmission efficiency of the parasite. Protozoan parasite Toxoplasma gondii infecting rats has been widely studied in this context. T. gondii increases attractiveness of infected male rats and reduces innate aversion of rats to cat odor, likely increasing transmission of the parasite by sexual and trophic routes respectively. It is currently unexplored if T. gondii induces gain of male attractiveness in experimental models other than rats. Here we show that laboratory infection of two strains of mice does not induce behavioral manipulation. Moreover, T. gondii infection results in reduction of male attractiveness in one of the strains. In agreement with this observation, T. gondii infection also fails to induce reduction in innate aversion to cat odors in mice. Effects of the parasite on mice mate choice are similar to effects of several other parasites in this animal model. Thus, behavioral change induced by the parasite may be specific to the rodent species.
authors.affiliation: School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 5637551, Singapore.
authors.forename: Linda Jing Ting
authors.initials: LJ
authors.lastname: Soh
authors.forename: Anand
authors.initials: A
authors.lastname: Vasudevan
authors.forename: Ajai
authors.initials: A
authors.lastname: Vyas
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D005239:Fear; D005260:Female; D006790:Host-Parasite Interactions; D007323:Instinct; D046008:Lynx; D008297:Male; D052586:Mating Preference, Animal; D051379:Mice; D008807:Mice, Inbred BALB C; D009812:Odorants; D013045:Species Specificity; D014122:Toxoplasma / Q000502:physiology*; D014124:Toxoplasmosis, Animal / Q000469:parasitology* / Q000523:psychology; D015431:Weight Loss
references.citation: Folia Parasitol (Praha). 2010 Jun;57(2):88-94
references.pmid: 20608470
references.citation: Dis Model Mech. 2013 Mar;6(2):516-20
references.pmid: 23104989
references.citation: Schizophr Bull. 2012 Nov;38(6):1155-61
references.pmid: 22941742
references.citation: Folia Parasitol (Praha). 2010 Jun;57(2):151-5
references.pmid: 20608478
references.citation: J Exp Biol. 2013 Jan 1;216(Pt 1):99-112
references.pmid: 23225872
references.citation: BMC Biol. 2010 Jun 03;8:75
references.pmid: 20525243
references.citation: Neuroscience. 2007 Aug 24;148(2):342-8
references.pmid: 17683872
references.citation: J Chem Ecol. 2011 Jul;37(7):687-94
references.pmid: 21647723
references.citation: PLoS One. 2008 Sep 25;3(9):e3280
references.pmid: 18815613
references.citation: Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6442-7
references.pmid: 17404235
references.citation: Physiol Behav. 1982 Jun;28(6):953-8
references.pmid: 7202224
references.citation: Neuroscience. 2012 Mar 29;206:39-48
references.pmid: 22240252
references.citation: J Exp Biol. 2013 Jan 1;216(Pt 1):3-10
references.pmid: 23225861
references.citation: Exp Parasitol. 2011 Jul;128(3):181-3
references.pmid: 21458453
references.citation: Peptides. 2004 Sep;25(9):1553-63
references.pmid: 15374657
references.citation: PLoS One. 2011;6(9):e23866
references.pmid: 21957440
references.citation: Horm Behav. 2002 Dec;42(4):448-60
references.pmid: 12488111
references.citation: Nat Methods. 2010 Apr;7(4):307-9
references.pmid: 20208532
references.citation: J Exp Biol. 2013 Jan 1;216(Pt 1):i-iv
references.pmid: 23355981
references.citation: J Exp Biol. 2013 Jan 1;216(Pt 1):120-6
references.pmid: 23225874
references.citation: PLoS One. 2011;6(11):e27229
references.pmid: 22073295
references.citation: Mol Ecol. 2013 Jan;22(1):102-10
references.pmid: 23190313
references.citation: Proc Biol Sci. 2000 Aug 7;267(1452):1591-4
references.pmid: 11007336
references.citation: PLoS One. 2009;4(3):e4801
references.pmid: 19277211
references.citation: PLoS One. 2011;6(8):e23277
references.pmid: 21858053
references.citation: J Exp Biol. 2013 Jan 1;216(Pt 1):113-9
references.pmid: 23225873
references.citation: PLoS One. 2012;7(3):e32489
references.pmid: 22431975
references.citation: Biol Psychiatry. 2006 May 1;59(9):872-4
references.pmid: 16458259
references.citation: Proc Biol Sci. 1995 Jul 22;261(1360):31-5
references.pmid: 7644547
references.citation: J Neuroinflammation. 2008 Oct 23;5:48
references.pmid: 18947414