title: The first inhibitor-based fluorescent imaging probe for aminopeptidase N.
abstract: Höltke and his co-workers firstly reported the synthesis and characterization of an inhibitor-based fluorescent imaging probe for aminopeptidase N. This fluorescent probe demonstrated high binding affinity to APN and could specifically bind to APN high expressed cells, thus revealed the distribution of APN. As a milestone, this outstanding work provided a useful tool to understand APN pathophysiology.
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Ji'nan, Shandong, China.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Chen
authors.forename: L P
authors.initials: LP
authors.lastname: Du
authors.forename: M Y
authors.initials: MY
authors.lastname: Li
mesh_terms: D018826:CD13 Antigens / Q000037:antagonists & inhibitors* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D018826:CD13 Antigens