title: Clinicopathological analysis of glomerulopathy with fibronectin deposits (GFND): a case of sporadic, elderly-onset GFND with codeposition of IgA, C1q, and fibrinogen.
abstract: A 67-year-old Japanese man with recurrent nephrotic syndrome and impaired kidney function had a sporadic, elderly-onset case of glomerulopathy with fibronectin deposits. The daily urinary protein, serum albumin, blood urea nitrogen, and creatinine levels were 3.6 g/day, 2.7 g/dL, 19.5 mg/dL, and 1.70 mg/dL, respectively. Kidney biopsy samples were evaluated using electron microscopy and demonstrated membranoproliferative glomerulonephritis-like lesions with massive subendothelial depositions and no fibrillary structures. Immunofluorescent studies showed 1+ staining for IgA, C1q, and fibrinogen. Anti-fibronectin immunostaining demonstrated that the subendothelial deposits were positive for fibronectin. The administration of prednisolone and mizoribine improved the nephrotic syndrome.
authors.affiliation: Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Japan.
authors.forename: Masabumi
authors.initials: M
authors.lastname: Yoshino
authors.forename: Naoto
authors.initials: N
authors.lastname: Miura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suzuki
authors.forename: Wataru
authors.initials: W
authors.lastname: Kitagawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Imai
mesh_terms: D017668:Age of Onset; D000368:Aged; D015922:Complement C1q / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012263:Ribonucleosides / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D005353:Fibronectins; D007070:Immunoglobulin A; D012263:Ribonucleosides; C010052:mizoribine; D015922:Complement C1q; D005340:Fibrinogen; D011239:Prednisolone