title: Medial prefrontal cortex supports source memory for self-referenced materials in young and older adults.
abstract: Behavioral evidence suggests that young and older adults show a benefit in source memory accuracy when processing materials in reference to the self. In the young, activity within the medial prefrontal cortex supports this source memory benefit at study. In this investigation, we examined whether the same neural regions support this memory benefit in both age groups. Using fMRI, we scanned participants while they studied and retrieved pictures of objects paired with one of three scenes (source) under self-reference and other-reference conditions. At the time of study, half of the items were presented once and half twice, allowing us to match behavioral performance between the groups. Both groups showed equivalent source accuracy benefits for objects encoded self-referentially. Activity in the left dorsal medial prefrontal cortex supported subsequent source memory in both age groups for the self-referenced relative to the other-referenced items. At the time of test, source accuracy for both the self- and other-referenced items was supported by a network of regions including the precuneus in both age groups. At both study and test, little in the way of age differences emerged, suggesting that when they are matched on behavioral performance, young and older adults engage similar regions in support of source memory when processing materials in reference to the self; however, when we did not match performance, age differences in functional recruitment were prevalent. These results suggest that by capitalizing on preserved processes (self-referential encoding), older adults can show improvement in memory for source details that they would typically not remember well, relative to the young.
authors.affiliation: School of Psychology, Center for Advanced Brain Imaging, Georgia Institute of Technology, JS Coon Building 654 Cherry Street, Atlanta, GA, 30332, USA, leshikar@brandeis.edu.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Leshikar
authors.forename: Audrey
authors.initials: A
authors.lastname: Duarte
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D013647:Task Performance and Analysis; D055815:Young Adult
references.citation: Neuron. 2006 May 18;50(4):655-63
references.pmid: 16701214
references.citation: J Cogn Neurosci. 2002 Jul 1;14(5):785-94
references.pmid: 12167262
references.citation: J Cogn Neurosci. 2011 Sep;23(9):2533-43
references.pmid: 21254802
references.citation: Cereb Cortex. 2007 Nov;17(11):2491-506
references.pmid: 17204820
references.citation: Neuroimage. 2004 Aug;22(4):1596-604
references.pmid: 15275916
references.citation: J Cogn Neurosci. 2010 Aug;22(8):1819-31
references.pmid: 19642880
references.citation: J Cogn Neurosci. 2004 Jun;16(5):760-75
references.pmid: 15200704
references.citation: Neuroimage. 2005 Apr 1;25(2):616-24
references.pmid: 15784441
references.citation: Neuroimage. 2011 Aug 1;57(3):1192-204
references.pmid: 21620979
references.citation: PLoS One. 2010 Oct 13;5(10):e13311
references.pmid: 20967203
references.citation: Vision Res. 2001;41(10-11):1409-22
references.pmid: 11322983
references.citation: J Pers Soc Psychol. 1977 Sep;35(9):677-88
references.pmid: 909043
references.citation: Psychol Aging. 1995 Dec;10(4):527-39
references.pmid: 8749580
references.citation: Nat Rev Neurosci. 2006 Apr;7(4):268-77
references.pmid: 16552413
references.citation: Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4259-64
references.pmid: 11259662
references.citation: Memory. 2009 Feb;17(2):144-57
references.pmid: 18608973
references.citation: J Neurosci. 2012 Feb 8;32(6):2154-8
references.pmid: 22323727
references.citation: Soc Neurosci. 2010;5(5-6):560-76
references.pmid: 20981629
references.citation: Cereb Cortex. 2005 Nov;15(11):1768-78
references.pmid: 15728740
references.citation: Soc Cogn Affect Neurosci. 2008 Sep;3(3):195-203
references.pmid: 19015111
references.citation: J Cogn Neurosci. 2004 Dec;16(10):1746-72
references.pmid: 15701226
references.citation: J Cogn Neurosci. 2010 Jul;22(7):1348-61
references.pmid: 19445606
references.citation: Soc Neurosci. 2012;7(2):126-45
references.pmid: 21936739
references.citation: Hippocampus. 1999;9(1):83-98
references.pmid: 10088903
references.citation: Cogn Affect Behav Neurosci. 2012 Jun;12(2):269-79
references.pmid: 22371086
references.citation: J Cogn Neurosci. 2012 Aug;24(8):1742-52
references.pmid: 22452556
references.citation: Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13091-5
references.pmid: 15322270
references.citation: Psychol Aging. 2011 Sep;26(3):636-46
references.pmid: 21480719
references.citation: J Cogn Neurosci. 2010 Jul;22(7):1623-35
references.pmid: 19580380
references.citation: Cereb Cortex. 2004 Jun;14(6):647-54
references.pmid: 15084488
references.citation: Neuropsychologia. 2008 Mar 7;46(4):1088-103
references.pmid: 18155254
references.citation: J Exp Psychol Learn Mem Cogn. 2008 Jul;34(4):791-808
references.pmid: 18605869
references.citation: J Neurosci. 2009 Jun 24;29(25):8270-9
references.pmid: 19553466
references.citation: Psychol Bull. 1993 Jul;114(1):3-28
references.pmid: 8346328
references.citation: Neuropsychologia. 2010 Jan;48(1):211-9
references.pmid: 19765600
references.citation: Cereb Cortex. 2012 Jan;22(1):37-50
references.pmid: 21616984
references.citation: Psychol Aging. 1990 Mar;5(1):119-26
references.pmid: 2317290
references.citation: Neurobiol Aging. 2008 Dec;29(12):1902-16
references.pmid: 17560691
references.citation: Soc Cogn Affect Neurosci. 2011 Jun;6(3):260-9
references.pmid: 20478834
references.citation: Brain Res. 2008 Dec 9;1244:121-31
references.pmid: 18848823
references.citation: J Cogn Neurosci. 2011 Sep;23(9):2222-30
references.pmid: 20946059
references.citation: Brain. 2003 Jan;126(Pt 1):213-29
references.pmid: 12477708
references.citation: Psychol Aging. 2002 Sep;17(3):405-15
references.pmid: 12243382
references.citation: Memory. 2007 Nov;15(8):822-37
references.pmid: 18033620
references.citation: Memory. 2004 Nov;12(6):673-84
references.pmid: 15724356
references.citation: J Exp Psychol Gen. 1986 Mar;115(1):26-38
references.pmid: 2937872
references.citation: Neuropsychologia. 2008;46(7):1787-99
references.pmid: 18343462
references.citation: Cogn Affect Behav Neurosci. 2008 Jun;8(2):153-64
references.pmid: 18589506
references.citation: Soc Cogn Affect Neurosci. 2006 Jun;1(1):18-25
references.pmid: 18985097
references.citation: J Res Pers. 2010 Feb 1;44(1):31-37
references.pmid: 20305728
references.citation: Neuropsychologia. 2007 Oct 1;45(13):2883-901
references.pmid: 17675110
references.citation: Neuropsychologia. 2010 Nov;48(13):3815-23
references.pmid: 20837034
references.citation: Neuropsychologia. 2010 Jan;48(1):137-44
references.pmid: 19720071
references.citation: Psychol Sci. 2002 Mar;13(2):101-5
references.pmid: 11933991
references.citation: PLoS One. 2012;7(5):e38160
references.pmid: 22693593
references.citation: Neuropsychologia. 2009 Apr;47(5):1352-61
references.pmid: 19428399
references.citation: Soc Neurosci. 2007;2(2):117-33
references.pmid: 18633811
references.citation: Neuroimage. 2010 May 1;50(4):1606-17
references.pmid: 20123026
references.citation: Psychol Bull. 2009 Jul;135(4):638-77
references.pmid: 19586165
references.citation: Psychol Aging. 2011 Sep;26(3):625-30
references.pmid: 21443350
references.citation: Neuroimage. 2010 May 15;51(1):336-44
references.pmid: 20139012
references.citation: Psychol Aging. 2005 Dec;20(4):571-8
references.pmid: 16420132
references.citation: J Exp Psychol Gen. 1988 Mar;117(1):34-50
references.pmid: 2966230
references.citation: Brain Res Cogn Brain Res. 2003 Jun;17(1):75-82
references.pmid: 12763194
references.citation: Neuroimage. 2007 Oct 15;38(1):95-113
references.pmid: 17761438
references.citation: Psychol Bull. 2005 May;131(3):383-406
references.pmid: 15869334
references.citation: Memory. 2011 Nov;19(8):1004-14
references.pmid: 22092106
references.citation: Nat Rev Neurosci. 2000 Oct;1(1):41-50
references.pmid: 11252767
references.citation: Cereb Cortex. 2008 Sep;18(9):2169-80
references.pmid: 18165281
references.citation: Psychol Bull. 1997 May;121(3):371-94
references.pmid: 9136641
references.citation: Soc Neurosci. 2010;5(2):187-200
references.pmid: 19787547
references.citation: Neuropsychology. 2010 Nov;24(6):698-710
references.pmid: 20873930
references.citation: J Neurosci. 2004 Nov 10;24(45):10223-8
references.pmid: 15537894
references.citation: Neuroimage. 2002 Jun;16(2):484-512
references.pmid: 12030833
references.citation: Pers Soc Psychol Rev. 2012 Aug;16(3):283-300
references.pmid: 22291045
references.citation: Annu Rev Neurosci. 2007;30:123-52
references.pmid: 17417939
references.citation: Hippocampus. 2007;17(9):873-89
references.pmid: 17604348
references.citation: Neurobiol Aging. 2012 Jul;33(7):1298-310
references.pmid: 21190759
references.citation: J Cogn Neurosci. 2005 Jan;17(1):84-96
references.pmid: 15701241
references.citation: Neurobiol Aging. 2013 Feb;34(2):451-67
references.pmid: 22542836
references.citation: Psychol Aging. 1986 Dec;1(4):293-9
references.pmid: 3267409
references.citation: J Neurosci. 2012 Apr 18;32(16):5553-61
references.pmid: 22514317
references.citation: Brain Res. 2011 Mar 4;1377:84-100
references.pmid: 21215731
references.citation: Neuroimage. 1997 May;5(4 Pt 1):261-70
references.pmid: 9345555