title: Genome-wide association study on differentiated thyroid cancer.
abstract: BACKGROUND
  Genome-wide association studies (GWASs) of differentiated thyroid cancer (DTC) have identified associations with polymorphisms at 2q35 (DIRC3), 8p12 (NRG1), 9q22.33 (FOXE1), and 14q13.2 (NKX2-1). However, most of the inherited genetic risk factors of DTC remain to be discovered.
  
  
  OBJECTIVE
  Our objective was to identify additional common DTC susceptibility loci.
  
  
  METHODS
  We conducted a GWAS in a high-incidence Italian population of 690 cases and 497 controls and followed up the most significant polymorphisms in 2 additional Italian series and in 3 low-incidence populations totaling 2958 cases and 3727 controls.
  
  
  RESULTS
  After excluding the most robust previously identified locus (9q22.33), the strongest association was shown by rs6759952, confirming the recently published association in DIRC3 (odds ratio [OR] = 1.21, P = 6.4 × 10(-10), GWAS and all replications combined). Additionally, in the combined analysis of the Italian series, suggestive associations were attained with rs10238549 and rs7800391 in IMMP2L (OR = 1.27, P = 4.1 × 10(-6); and OR = 1.25, P = 5.7 × 10(-6)), rs7617304 in RARRES1 (OR = 1.25, P = 4.6 × 10(-5)) and rs10781500 in SNAPC4/CARD9 (OR = 1.23, P = 3.5 × 10(-5)).
  
  
  CONCLUSIONS
  Our findings provide additional insights into the genetic and biological basis of inherited genetic susceptibility to DTC. Additional studies are needed to determine the role of the identified polymorphisms in the development of DTC and their possible use in the clinical practice.
authors.affiliation: PhD, Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. a.foersti@dkfz-heidelberg.de.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Köhler
authors.forename: Bowang
authors.initials: B
authors.lastname: Chen
authors.forename: Federica
authors.initials: F
authors.lastname: Gemignani
authors.forename: Rossella
authors.initials: R
authors.lastname: Elisei
authors.forename: Cristina
authors.initials: C
authors.lastname: Romei
authors.forename: Gisella
authors.initials: G
authors.lastname: Figlioli
authors.forename: Monica
authors.initials: M
authors.lastname: Cipollini
authors.forename: Alfonso
authors.initials: A
authors.lastname: Cristaudo
authors.forename: Franco
authors.initials: F
authors.lastname: Bambi
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Stefan
authors.initials: S
authors.lastname: Herms
authors.forename: Michal
authors.initials: M
authors.lastname: Kalemba
authors.forename: Dorota
authors.initials: D
authors.lastname: Kula
authors.forename: Shelley
authors.initials: S
authors.lastname: Harris
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.forename: Richard
authors.initials: R
authors.lastname: Houlston
authors.forename: Susana
authors.initials: S
authors.lastname: Pastor
authors.forename: Ricard
authors.initials: R
authors.lastname: Marcos
authors.forename: Antonia
authors.initials: A
authors.lastname: Velázquez
authors.forename: Barbara
authors.initials: B
authors.lastname: Jarzab
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
authors.forename: Stefano
authors.initials: S
authors.lastname: Landi
authors.forename: Asta
authors.initials: A
authors.lastname: Försti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology