title: Nutrition disorder and systemic inflammation in patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  To detect nutrition disorders (underweight and obesity) in patients with chronic obstructive disease (COPD) and presence of systemic inflammation by determination of inflammatory mediators serum values C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and leptin.
  
  
  METHODS
  The examination involved 85 patients with COPD. Nutrition categories were defined by body mass index (BMI). Fat free mass (FFM) was evaluated by mid upper-arm circumference (MUAC) and fat mass (FM) by tricipital skin-fold thickness (TFS). Values of TNF-α and leptin were measured by standardized ELISA kits and, CRP by latex turbidimetry.
  
  
  RESULTS
  There were 14 (16.5%) underweight patients, 28 (32.9%) normal, 28 (32.9%) pre-obese and 15 (17.6%) obese. Values of MUAC and TSF were significantly different among the nutrition categories (p=0.000). The lowest MUAC and TSF values were in the underweight, and the highest in the obese. There was no significant difference of CRP and TNF-α among nutrition categories. Leptin of the underweight and normal nutrition was significantly different from leptin of the pre-obese and obese (p=0.000). The highest CRP and the lowest TNF-α and leptin were in the underweight patients. The obese had the lowest CRP (although increased as compared to normal values) and the highest leptin, while the pre-obese had the highest TNF-α.
  
  
  CONCLUSIONS
  Two basic nutrition disorders (underweight and obesity) were manifested in COPD patients. The inflammatory profile differs between underweight COPD patients and obese. Probably that happens due to systemic inflammation, and in part due to dysfunction of adipose tissue.
authors.affiliation: University of Nis, School of Medicine, Clinic for Lung Diseases "Knez Selo", Clinical Centre of Niš, Niš, Serbia.
authors.forename: Zorica
authors.initials: Z
authors.lastname: Cirić
authors.forename: Ivana
authors.initials: I
authors.lastname: Stanković
authors.forename: Tatjana
authors.initials: T
authors.lastname: Pejčić
authors.forename: Lidija
authors.initials: L
authors.lastname: Ristić
authors.forename: Milan
authors.initials: M
authors.lastname: Rančić
authors.forename: Milan
authors.initials: M
authors.lastname: Radović
authors.forename: Desa
authors.initials: D
authors.lastname: Nastasijević-Borovec
mesh_terms: D015992:Body Mass Index; D002097:C-Reactive Protein; D006801:Humans; D007249:Inflammation; D020738:Leptin / Q000097:blood; D029424:Pulmonary Disease, Chronic Obstructive; D014409:Tumor Necrosis Factor-alpha
chemical_list: D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein