title: Expression of the interleukin 17 in cortical tubers of the tuberous sclerosis complex.
abstract: The role of interleukin 17 (IL-17) to epilepsy-associated cortical tubers of tuberous sclerosis complex (TSC) is unknown. We investigated the expression patterns of the IL-17 and IL-17 receptor (IL-17R) in cortical tubers of TSC compared with normal control cortex (CTX). We found that IL-17 and IL-17R were clearly upregulated in cortical tubers at the protein levels. Immunostaining indicated that IL-17 was specifically distributed in the innate immunity cells (DNs, GCs, astrocytes, and microglia) and adaptive immunity cells (T-lymphocytes) as well as the endothelial cells of blood vessels. The overexpression and distribution patterns of IL-17 may be involved in the epileptogenicity of cortical tubers in TSC.
authors.affiliation: Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Jiao-Jiang
authors.initials: JJ
authors.lastname: He
authors.forename: Ke-Fu
authors.initials: KF
authors.lastname: Wu
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Shu
authors.forename: Chun-Qing
authors.initials: CQ
authors.lastname: Zhang
authors.forename: Shi-Yong
authors.initials: SY
authors.lastname: Liu
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Yang
authors.forename: Qing
authors.initials: Q
authors.lastname: Yin
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
mesh_terms: D002540:Cerebral Cortex / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000209:etiology / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D020381:Interleukin-17 / Q000096:biosynthesis / Q000235:genetics*; D008297:Male; D053722:Receptors, Interleukin-17 / Q000096:biosynthesis / Q000235:genetics; D014402:Tuberous Sclerosis / Q000150:complications / Q000276:immunology* / Q000473:pathology
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: Epilepsy; Inflammatory cytokine; Interleukin 17; Tuberous sclerosis complex