title: 2,2'-Biphenols via protecting group-free thermal or microwave-accelerated Suzuki-Miyaura coupling in water.
abstract: User-friendly protocols for the protecting group-free synthesis of 2,2'-biphenols via Suzuki-Miyaura coupling of o-halophenols and o-boronophenol are presented. The reactions proceed in water in the presence of simple additives such as K2CO3, KOH, KF, or TBAF and with commercially available Pd/C as precatalyst. Expensive or laboriously synthesized ligands or other additives are not required. In the case of bromophenols, efficient rate acceleration and short reaction times were accomplished by microwave irradiation.
authors.affiliation: Institut fuer Chemie (Organische Synthesechemie), Universitaet Potsdam, Karl-Liebknecht-Strasse 24-25, D-14476 Potsdam-Golm, Germany. bernd.schmidt@uni-potsdam.de
authors.forename: Bernd
authors.initials: B
authors.lastname: Schmidt
authors.forename: Martin
authors.initials: M
authors.lastname: Riemer
authors.forename: Manfred
authors.initials: M
authors.lastname: Karras
mesh_terms: D008872:Microwaves; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D010636:Phenols; D014867:Water; C038764:2,2'-biphenol