title: Chronic inflammatory demyelinating polyneuropathy of childhood: clinical and neuroradiological findings.
abstract: BACKGROUND
  This study aims to report on serial magnetic resonance imaging (MRI) studies and clinical features in a cohort of children with chronic inflammatory demyelinating polyneuropathy (CIDP).
  
  
  METHODS
  Clinical, neuroradiological, and statistical investigations performed on nine children with CIDP were retrospectively reviewed. Pathological nerve root enhancement was categorized according to severity, extension, and morphology. A MRI score was thus obtained, and correlations with the clinical picture and disease course were explored.
  
  
  RESULTS
  Intrathecal nerve root enhancement (NRE) of varying degrees was seen in a high percentage of patients. There was no significant correlation between the total MRI score at the first MRI study and either severity or course of the disease. However, we found a significant difference (p = 0.002) in NRE of patients with improving CIDP with respect to those with stable or progressing disease at the time of follow-up MRI.
  
  
  CONCLUSIONS
  Contrast-enhanced MRI plays a pivotal role in children with CIDP, both for the initial diagnosis as well as a biomarker of clinical evolution, and should be performed in all children with suspected CIDP both at initial presentation and during follow-up. Further multicenter studies on larger cohorts are awaited to determine the ideal timing for follow-up MRI.
authors.affiliation: Child Neuropsychiatry Unit, G. Gaslini Institute, Largo G. Gaslini 5, 16147, Genoa, Italy, danielapaolarossi@fastwebnet.it.
authors.forename: D P
authors.initials: DP
authors.lastname: Rossi
authors.forename: L
authors.initials: L
authors.lastname: Doria Lamba
authors.forename: A
authors.initials: A
authors.lastname: Pistorio
authors.forename: M
authors.initials: M
authors.lastname: Pedemonte
authors.forename: E
authors.initials: E
authors.lastname: Veneselli
authors.forename: A
authors.initials: A
authors.lastname: Rossi
mesh_terms: D000293:Adolescent; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013126:Spinal Nerve Roots / Q000473:pathology*
chemical_list: D003287:Contrast Media; D005682:Gadolinium
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