title: Microwave- and ultrasound-assisted synthesis of some acyclonucleobases based on a uracil moiety using dmap as base.
abstract: In this study, 1-(bromoalkanoyl)-1H-pyrimidine-2,4-diones, (2,4-dioxo-pyrimidin-1-yl)-oxo-alkanoic acids, and bis(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-alkanones were successfully prepared via electrophilic substitution of uracil and its derivatives. High yields and pure products were obtained when microwave and ultrasound methodologies were used for undertaking the reactions. Importantly, the use of 4-dimethylaminopyridine in the present investigation gave rise to higher conversions of the starting material and afforded facile access to regioselective N-1 products.
authors.affiliation: Department of Chemistry, Faculty of Science, Center for Female Scientific and Medical Colleges, King Saud University, Riyadh, 11495, Saudi Arabia. slahsasni@ksu.edu.sa
authors.forename: Siham A
authors.initials: SA
authors.lastname: Lahsasni
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D003500:Cyclization; D008872:Microwaves; D009696:Nucleic Acids / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D014465:Ultrasonics; D014498:Uracil / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D009696:Nucleic Acids; D011743:Pyrimidines; D014498:Uracil; D015761:4-Aminopyridine; C030986:pyrimidine; C003885:4-dimethylaminopyridine