title: A new kaempferol trioside from Silphium perfoliatum.
abstract: A new apiose-containing kaempferol trioside, kaempferol-3-O-α-L-rhamnosyl-(1‴ → 6″)-O-β-D-galactopyranosyl-7-O-β-D-apiofuranoside, along with 16 known compounds, were isolated from 50% acetone extract of Silphium perfoliatum L. Their structures were elucidated by acid hydrolysis and spectroscopic techniques including UV, IR, MS, ¹H, ¹³C, and 2D-NMR. In addition, the pharmacological activity of compound 1 was tested with HepG2 and Balb/c mice (splenic lymphocytes and thymic lymphocytes) in vitro, and it exhibited inhibitory effect on the proliferation of HepG2 cells and showed the immunosuppressive activity.
authors.affiliation: a School of Pharmacy, Henan University of Traditional Chinese Medicine , Zhengzhou 450046 , China.
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Feng
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Pei
authors.forename: Xiao-Ke
authors.initials: XK
authors.lastname: Zheng
authors.forename: Chun-Ge
authors.initials: CG
authors.lastname: Li
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Ke
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Lv
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification*; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D007166:Immunosuppressive Agents; D044949:Kaempferols; C000588517:kaempferol-3-O-alpha-L-rhamnosyl-(1''-6')-O-beta-D-galactopyranosyl-7-O-beta-D-apiofuranoside