title: Axis I psychiatric diagnoses in adolescents and young adults with 22q11 deletion syndrome.
abstract: BACKGROUND
  22q11.2 deletion syndrome (22q11DS) associates with schizophrenia spectrum disorders (SSDs), autism spectrum disorders (ASDs), and other psychiatric disorders, but co-occurrence of diagnoses are not well described.
  
  
  METHODS
  We evaluated the co-occurrence of SSDs, ASDs and other axis I psychiatric diagnoses in 31 adolescents and adults with 22q11DS, assessing ASDs using either stringent Collaborative Program for Excellence in Autism (ASD-CPEA) criteria, or less stringent DSM-IV criteria alone (ASD-DSM-IV).
  
  
  RESULTS
  Ten (32%) individuals met criteria for an SSD, five (16%) for ASD-CPEA, and five others (16%) for ASD-DSM-IV. Of those with ASD-CPEA, one (20%) met SSD criteria. Of those with ASD-DSM-IV, four (80%) met SSD criteria. Depressive disorders (8 individuals; 26%) and anxiety disorders (7; 23%) sometimes co-occurred with SSDs and ASDs. SSDs, ASDs, and anxiety occurred predominantly among males and depression predominantly among females.
  
  
  CONCLUSIONS
  Individuals with 22q11DS can manifest SSDs in the presence or absence of ASDs and other axis I diagnoses. The results suggest that standard clinical care should include childhood screening for ASDs, and later periodic screening for all axis I diagnoses.
authors.affiliation: Emory University School of Medicine, Emory Autism Center, Department of Psychiatry and Behavioral Sciences, 1551 Shoup Court, 30322 Atlanta, Georgia, United States. Electronic address: oousley@emory.edu.
authors.forename: O Y
authors.initials: OY
authors.lastname: Ousley
authors.forename: E
authors.initials: E
authors.lastname: Smearman
authors.forename: S
authors.initials: S
authors.lastname: Fernandez-Carriba
authors.forename: K A
authors.initials: KA
authors.lastname: Rockers
authors.forename: K
authors.initials: K
authors.lastname: Coleman
authors.forename: E F
authors.initials: EF
authors.lastname: Walker
authors.forename: J F
authors.initials: JF
authors.lastname: Cubells
mesh_terms: D058165:22q11 Deletion Syndrome / Q000150:complications* / Q000523:psychology; D000293:Adolescent; D000328:Adult; D002659:Child Development Disorders, Pervasive / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications* / Q000175:diagnosis / Q000523:psychology
keywords: Affective disorders; Anxiety disorders; Autism; Genetics; Schizophrenia and psychosis
references.citation: Nature. 2008 Sep 11;455(7210):237-41
references.pmid: 18668038
references.citation: J Am Acad Child Adolesc Psychiatry. 2009 Jan;48(1):10-8
references.pmid: 19218893
references.citation: Genet Med. 2001 Jan-Feb;3(1):79-84
references.pmid: 11339385
references.citation: Schizophr Bull. 2003;29(4):703-15
references.pmid: 14989408
references.citation: Neuron. 2011 Jun 9;70(5):863-85
references.pmid: 21658581
references.citation: J Autism Dev Disord. 2007 Oct;37(9):1776-86
references.pmid: 17180713
references.citation: Am J Psychiatry. 2011 Mar;168(3):302-16
references.pmid: 21285140
references.citation: Neuron. 2011 Jun 9;70(5):886-97
references.pmid: 21658582
references.citation: Curr Psychiatry Rep. 2011 Apr;13(2):129-37
references.pmid: 21253883
references.citation: Nat Rev Neurosci. 2010 Jun;11(6):402-16
references.pmid: 20485365
references.citation: J Psychiatr Res. 2010 Nov;44(15):1005-9
references.pmid: 20643418
references.citation: Asian J Psychiatr. 2011 Jun 1;4(2):119-124
references.pmid: 21743818
references.citation: Schizophr Res. 2011 Jun;129(1):20-8
references.pmid: 21507614
references.citation: J Am Acad Child Adolesc Psychiatry. 2006 Sep;45(9):1104-1113
references.pmid: 16926618
references.citation: Curr Psychiatry Rep. 2007 Apr;9(2):148-58
references.pmid: 17389127
references.citation: Am J Psychiatry. 2003 Sep;160(9):1580-6
references.pmid: 12944331
references.citation: J Autism Dev Disord. 2000 Jun;30(3):205-23
references.pmid: 11055457
references.citation: Brain Behav Immun. 2013 Jul;31:76-81
references.pmid: 23353117
references.citation: Am J Med Genet. 1992 Jan 1;42(1):141-2
references.pmid: 1308357
references.citation: Br J Psychiatry. 2005 Feb;186:115-20
references.pmid: 15684233
references.citation: Schizophr Bull. 2001;27(4):563-70
references.pmid: 11824483
references.citation: J Autism Dev Disord. 2005 Aug;35(4):461-70
references.pmid: 16134031
references.citation: J Autism Dev Disord. 2011 Sep;41(9):1256-66
references.pmid: 21153873
references.citation: Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7612-6
references.pmid: 7644464
references.citation: Am J Med Genet. 2001 May 8;105(4):354-62
references.pmid: 11378850
references.citation: Biol Psychiatry. 2011 May 15;69(10):945-52
references.pmid: 21195387
references.citation: Am J Psychiatry. 2002 May;159(5):863-5
references.pmid: 11986145
references.citation: Brain Res. 2011 Mar 22;1380:34-41
references.pmid: 21078305
references.citation: Pediatrics. 2003 Jul;112(1 Pt 1):101-7
references.pmid: 12837874
references.citation: J Pediatr. 2011 Aug;159(2):332-9.e1
references.pmid: 21570089
references.citation: J Ment Health Res Intellect Disabil. 2009 Apr;2(2):149-167
references.pmid: 20111667
references.citation: J Autism Dev Disord. 1994 Oct;24(5):659-85
references.pmid: 7814313
references.citation: J Am Acad Child Adolesc Psychiatry. 2006 May;45(5):596-603
references.pmid: 16670654
references.citation: J Intellect Disabil Res. 2009 Jul;53(7):665-76
references.pmid: 19460069
references.citation: J Nerv Ment Dis. 1994 Aug;182(8):476-8
references.pmid: 8040660
references.citation: Am J Psychiatry. 1996 Dec;153(12):1541-7
references.pmid: 8942449
references.citation: Schizophr Res. 2013 Jan;143(1):55-9
references.pmid: 23153825
references.citation: Arch Dis Child. 2004 Feb;89(2):148-51
references.pmid: 14736631