title: Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study.
abstract: Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen-positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals.
authors.affiliation: Department of Infectious Diseases, Bern University Hospital and University of Bern.
authors.forename: Gilles
authors.initials: G
authors.lastname: Wandeler
authors.forename: Thomas
authors.initials: T
authors.lastname: Gsponer
authors.forename: Florian
authors.initials: F
authors.lastname: Bihl
authors.forename: Enos
authors.initials: E
authors.lastname: Bernasconi
authors.forename: Matthias
authors.initials: M
authors.lastname: Cavassini
authors.forename: Helen
authors.initials: H
authors.lastname: Kovari
authors.forename: Patrick
authors.initials: P
authors.lastname: Schmid
authors.forename: Manuel
authors.initials: M
authors.lastname: Battegay
authors.forename: Alexandra
authors.initials: A
authors.lastname: Calmy
authors.forename: Matthias
authors.initials: M
authors.lastname: Egger
authors.forename: Hansjakob
authors.initials: H
authors.lastname: Furrer
authors.forename: Andri
authors.initials: A
authors.lastname: Rauch
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D060085:Coinfection / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D005260:Female; D006678:HIV / Q000187:drug effects / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006515:Hepatitis B virus / Q000187:drug effects / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents
keywords: anti-hepatitis B core antigen alone; antiretroviral therapy outcomes; hepatitis B infection; immunological recovery