title: Two novel tyrosinase inhibitory sesquiterpenes induced by CuCl2 from a marine-derived fungus Pestalotiopsis sp. Z233.
abstract: Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7β H-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11, 14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl2. Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC50 value of 14.8 µM and 22.3 µM.
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China. bwu@geomar.de
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Wu
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.forename: Minhui
authors.initials: M
authors.lastname: Li
mesh_terms: D003300:Copper / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D044647:Sargassum / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013312:Stress, Physiological; D013098:Xylariales / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: C586883:1,5,6,14-tetraacetoxy-9-benzoyloxy-7H-eudesman-2,11-diol; C586884:4,5-diacetoxy-9-benzoyloxy-7H-eudesman-1,2,11,14-tetraol; D004791:Enzyme Inhibitors; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D003300:Copper; D014442:Monophenol Monooxygenase; C029892:cupric chloride
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