title: Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny.
abstract: Genetic variation within the male-specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing of 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 of which have not previously been observed. We constructed a MSY phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters within each haplogroup. The tree was calibrated with archaeological data from the initial expansion of the Sardinian population ~7700 years ago. The ages of nodes highlight different genetic strata in Sardinia and reveal the presumptive timing of coalescence with other human populations. We calculate a putative age for coalescence of ~180,000 to 200,000 years ago, which is consistent with previous mitochondrial DNA-based estimates.
authors.affiliation: Dipartimento di Scienze della Natura e del Territorio, Università di Sassari, Sassari, Italy. pfrancalacci@uniss.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Francalacci
authors.forename: Laura
authors.initials: L
authors.lastname: Morelli
authors.forename: Andrea
authors.initials: A
authors.lastname: Angius
authors.forename: Riccardo
authors.initials: R
authors.lastname: Berutti
authors.forename: Frederic
authors.initials: F
authors.lastname: Reinier
authors.forename: Rossano
authors.initials: R
authors.lastname: Atzeni
authors.forename: Rosella
authors.initials: R
authors.lastname: Pilu
authors.forename: Fabio
authors.initials: F
authors.lastname: Busonero
authors.forename: Andrea
authors.initials: A
authors.lastname: Maschio
authors.forename: Ilenia
authors.initials: I
authors.lastname: Zara
authors.forename: Daria
authors.initials: D
authors.lastname: Sanna
authors.forename: Antonella
authors.initials: A
authors.lastname: Useli
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Urru
authors.forename: Marco
authors.initials: M
authors.lastname: Marcelli
authors.forename: Roberto
authors.initials: R
authors.lastname: Cusano
authors.forename: Manuela
authors.initials: M
authors.lastname: Oppo
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zoledziewska
authors.forename: Maristella
authors.initials: M
authors.lastname: Pitzalis
authors.forename: Francesca
authors.initials: F
authors.lastname: Deidda
authors.forename: Eleonora
authors.initials: E
authors.lastname: Porcu
authors.forename: Fausto
authors.initials: F
authors.lastname: Poddie
authors.forename: Hyun Min
authors.initials: HM
authors.lastname: Kang
authors.forename: Robert
authors.initials: R
authors.lastname: Lyons
authors.forename: Brendan
authors.initials: B
authors.lastname: Tarrier
authors.forename: Jennifer Bragg
authors.initials: JB
authors.lastname: Gresham
authors.forename: Bingshan
authors.initials: B
authors.lastname: Li
authors.forename: Sergio
authors.initials: S
authors.lastname: Tofanelli
authors.forename: Santos
authors.initials: S
authors.lastname: Alonso
authors.forename: Mariano
authors.initials: M
authors.lastname: Dei
authors.forename: Sandra
authors.initials: S
authors.lastname: Lai
authors.forename: Antonella
authors.initials: A
authors.lastname: Mulas
authors.forename: Michael B
authors.initials: MB
authors.lastname: Whalen
authors.forename: Sergio
authors.initials: S
authors.lastname: Uzzau
authors.forename: Chris
authors.initials: C
authors.lastname: Jones
authors.forename: David
authors.initials: D
authors.lastname: Schlessinger
authors.forename: Gonçalo R
authors.initials: GR
authors.lastname: Abecasis
authors.forename: Serena
authors.initials: S
authors.lastname: Sanna
authors.forename: Carlo
authors.initials: C
authors.lastname: Sidore
authors.forename: Francesco
authors.initials: F
authors.lastname: Cucca
mesh_terms: D000328:Adult; D041322:Chromosomes, Human, Y / Q000145:classification* / Q000235:genetics*; D019143:Evolution, Molecular; D006239:Haplotypes; D006801:Humans; D007558:Italy; D008297:Male; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics*
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