title: [The significance of urine N-acetyl-beta-D-glucosaminidase in kidney injury with patients acute paraquat poisoning].
abstract: OBJECTIVE
  To test the hypothesis that urine N-acetyl-beta-D-glucosaminidase (NAG) is a nearly biomarker for acute kidney injury in patients with acute paraquat poisoning.
  
  
  METHODS
  Forty-four patients with paraquat intoxication and 40 age and gender-matched healthy control participants were recruited. The urine N-acetyl-beta-D-glucosaminidase was determined by spectrophotometric methods.
  
  
  RESULTS
  The urine N-acetyl-beta-D-glucosaminidase activities in the patients with paraquat poisoning were higher than the corresponding values in the control participants (P<0.01); The prevalence rate of mortality was significantly higher in subjects with N-acetyl-beta-D-glucosaminidase activities ≥25 U/g Cr than in those N-acetyl-beta-D-glucosaminidase activities <25 Ulg Cr (34.4% vs 16.7%, P<0.01).
  
  
  CONCLUSIONS
  The urine N-acetyl-beta-D-glucosaminidase could be used as an early biomarker for acute kidney injury and predictor of mortality inpatients with acute paraquat intoxication.
authors.affiliation: Huzhou Central Blood Station, Huzhou ZhejiangProvince, China.
authors.forename: Xu-bin
authors.initials: XB
authors.lastname: Shi
authors.forename: Jun-ling
authors.initials: JL
authors.lastname: He
authors.forename: Yuang-qiang
authors.initials: YQ
authors.lastname: Lu
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010269:Paraquat / Q000506:poisoning*; D055815:Young Adult
chemical_list: D000118:Acetylglucosaminidase; D010269:Paraquat