title: Dentin adhesion and MMPs: a comprehensive review.
abstract: This review examines the fundamental processes responsible for the aging mechanisms involved in the degradation of resin-bonded interfaces, as well as some potential approaches to prevent and counteract this degradation. Current research in several research centers aims at increasing the resin-dentin bond durability. The hydrophilic and acidic characteristics of current dentin adhesives have made hybrid layers highly prone to water sorption. This, in turn, causes polymer degradation and results in decreased resin-dentin bond strength over time. These unstable polymers inside the hybrid layer may result in denuded collagen fibers, which become vulnerable to mechanical and hydrolytical fatigue, as well as degradation by host-derived proteases with collagenolytic activity. These enzymes, such as matrix metalloproteinases and cysteine cathepsins, have a crucial role in the degradation of type I collagen, the organic component of the hybrid layer. This review will also describe several methods that have been recently advocated to silent the activity of these endogenous proteases.
authors.affiliation: Department of Restorative Sciences, University of Minnesota, Minneapolis, MN 55455, USA. perdi001@umn.edu
authors.forename: Jorge
authors.initials: J
authors.lastname: Perdigão
authors.forename: Alessandra
authors.initials: A
authors.lastname: Reis
authors.forename: Alessandro D
authors.initials: AD
authors.lastname: Loguercio
mesh_terms: D065966:Absorption, Physicochemical; D000327:Adsorption; D001840:Dental Bonding; D003804:Dentin / Q000648:ultrastructure*; D017220:Dentin-Bonding Agents / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D061965:Matrix Metalloproteinase Inhibitors / Q000494:pharmacology; D020782:Matrix Metalloproteinases / Q000502:physiology*; D058105:Polymerization; D013314:Stress, Mechanical
chemical_list: D017220:Dentin-Bonding Agents; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases