title: Formulation development of antibody-drug conjugates.
abstract: Formulation development of an ADC resembles that of a conventional antibody, but the conjugated form introduces new molecular attributes such as drug-to-antibody ratio and stability of the drug itself that need to be considered. An extended set of analytical tools, coupled with understanding of how ADCs and conventional antibodies differ in terms of their stability, guides formulation selection.
authors.affiliation: Early Stage Pharmaceutical Development, Genentech Inc., South San Francisco, CA, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Galush
authors.forename: Aditya A
authors.initials: AA
authors.lastname: Wakankar
mesh_terms: D055592:Biophysical Phenomena; D002623:Chemistry Techniques, Analytical; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004355:Drug Stability; D018796:Immunoconjugates / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D018796:Immunoconjugates; D004364:Pharmaceutical Preparations