title: Analysis of spectral domain optical coherence tomography measurements in optic neuritis: differences in neuromyelitis optica, multiple sclerosis, isolated optic neuritis and normal healthy controls.
abstract: OBJECTIVE
  To compare the retinal layer thickness of eyes with optic neuritis (ON) and that of control eyes and ON eyes with and without neuromyelitis optica (NMO) or multiple sclerosis (MS).
  
  
  METHODS
  Horizontal and vertical SD-OCT scans of the fovea were undertaken for 56 patients with ON with and without NMO or MS and for 24 healthy controls. Patients with ON were divided into three groups: NMO, MS and isolated ON without NMO or MS. The thickness of each retinal layer was compared between ON and healthy control eyes, and between ON eyes with and without NMO or MS.
  
  
  RESULTS
  Compared with healthy control eyes, ON eyes showed significant thinning of the ganglion cell layer plus the inner plexiform layer (GCL + IPL) at all eight inner and outer macular locations. Significant differences in thickness were observed for the retinal layers of NMO, MS and isolated ON without NMO or MS at several retinal locations.
  
  
  CONCLUSIONS
  Our SD-OCT data revealed a notable difference in the GCL + IPL thickness between ON and healthy control eyes. It also showed differences in the thickness of several retinal layers for ON subgroups including NMO, MS and isolated ON. This may be helpful for distinguishing the aetiology of ON.
authors.affiliation: Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Kyung-Ah
authors.initials: KA
authors.lastname: Park
authors.forename: Jaeryung
authors.initials: J
authors.lastname: Kim
authors.forename: Sei Yeul
authors.initials: SY
authors.lastname: Oh
mesh_terms: D000328:Adult; D055253:Color Vision / Q000502:physiology; D015350:Contrast Sensitivity / Q000502:physiology; D003937:Diagnosis, Differential; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009471:Neuromyelitis Optica / Q000175:diagnosis*; D009902:Optic Neuritis / Q000175:diagnosis*; D009929:Organ Size; D055351:Retinal Neurons / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology
keywords: multiple sclerosis; neuromyelitis optica; optic neuritis; spectral domain optical coherence tomography