title: Renal and cardiac effects of renal sympathetic denervation and carotid baroreceptor stimulation.
abstract: Cumulative evidence nowadays supports the dominant role of sympathetic nervous system (SNS) activation in patients with hypertension, congestive heart failure, and renal dysfunction. During the last years innovative interventional treatments [renal sympathetic denervation (RSD) and baroreflex activation therapy (BAT)] have emerged and accompanied by sustained reductions of blood pressure (BP) levels. Moreover, these promising therapies are favorable not only on BP regulation but also on the SNS overdrive-related organ damage. The present review focuses on the association of SNS activation with renal and cardiac diseases and presents the cardiorenal effects of RSD and BAT in experimental and clinical settings.
authors.forename: Costas
authors.initials: C
authors.lastname: Tsioufis
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Dimitriadis
authors.forename: Costas
authors.initials: C
authors.lastname: Thomopoulos
authors.forename: Michalis
authors.initials: M
authors.lastname: Doumas
authors.forename: Vasilios
authors.initials: V
authors.lastname: Papademetriou
authors.affiliation: 3 Kolokotroni Street, 15236 P.Panteli, Athens, Greece. ktsioufis@hippocratio.gr.
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D002346:Carotid Sinus / Q000503:physiopathology*; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods*; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D013562:Sympathectomy / Q000009:adverse effects / Q000379:methods*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D016896:Treatment Outcome