title: The endothelial protein C receptor and malaria.
abstract: In this issue of Blood, Moxon et al provide novel insight into the pathogenesis of cerebral malaria, linking loss of the endothelial protein C receptor (EPCR) on brain vessels, caused by cytoadherent infected erythrocytes, with localized coagulation, inflammation, and disruption of endothelial barrier function.
authors.affiliation: University of Amsterdam.
authors.forename: Tom
authors.initials: T
authors.lastname: van der Poll
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D001777:Blood Coagulation / Q000502:physiology*; D001921:Brain / Q000469:parasitology*; D000074283:Endothelial Protein C Receptor; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation; D016779:Malaria, Cerebral / Q000469:parasitology*; D008297:Male; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D011956:Receptors, Cell Surface