title: Sepsis-associated mortality in England: an analysis of multiple cause of death data from 2001 to 2010.
abstract: OBJECTIVE
  To quantify mortality associated with sepsis in the whole population of England.
  
  
  METHODS
  Descriptive statistics of multiple cause of death data.
  
  
  METHODS
  England between 2001 and 2010.
  
  
  METHODS
  All people whose death was registered in England between 2001 and 2010 and whose certificate contained a sepsis-associated International Classification of Diseases, 10th Revision (ICD-10) code.
  
  
  METHODS
  Multiple cause of death data extracted from Office for National Statistics mortality database.
  
  
  METHODS
  Age-specific and sex-specific death rates and direct age-standardised death rates.
  
  
  RESULTS
  In 2010, 5.1% of deaths in England were definitely associated with sepsis. Adding those that may be associated with sepsis increases this figure to 7.7% of all deaths. Only 8.6% of deaths definitely associated with sepsis in 2010 had a sepsis-related condition as the underlying cause of death. 99% of deaths definitely associated with sepsis have one of the three ICD-10 codes-A40, A41 and P36-in at least one position on the death certificate. 7% of deaths definitely associated with sepsis in 2001-2010 did not occur in hospital.
  
  
  CONCLUSIONS
  Sepsis is a major public health problem in England. In attempting to tackle the problem of sepsis, it is not sufficient to rely on hospital-based statistics, or methods of intervention, alone. A robust estimate of the burden of sepsis-associated mortality in England can be made by identifying deaths with one of the three ICD-10 codes in multiple cause of death data. These three codes could be used for future monitoring of the burden of sepsis-associated mortality.
authors.affiliation: Imperial College London, London, UK.
authors.forename: Duncan
authors.initials: D
authors.lastname: McPherson
authors.forename: Clare
authors.initials: C
authors.lastname: Griffiths
authors.forename: Matthew
authors.initials: M
authors.lastname: Williams
authors.forename: Allan
authors.initials: A
authors.lastname: Baker
authors.forename: Ed
authors.initials: E
authors.lastname: Klodawski
authors.forename: Bobbie
authors.initials: B
authors.lastname: Jacobson
authors.forename: Liam
authors.initials: L
authors.lastname: Donaldson
keywords: EPIDEMIOLOGY; PUBLIC HEALTH; STATISTICS & RESEARCH METHODS
references.citation: Crit Care Med. 2003 Sep;31(9):2332-8
references.pmid: 14501964
references.citation: Health Stat Q. 2004 Spring;(21):15-22
references.pmid: 15615149
references.citation: Crit Care Med. 2001 Jul;29(7):1303-10
references.pmid: 11445675
references.citation: Health Stat Q. 2004 Spring;(21):23-9
references.pmid: 15615150
references.citation: Diabetologia. 1983 May;24(5):336-41
references.pmid: 6873513
references.citation: Intensive Care Med. 2003 Apr;29(4):530-8
references.pmid: 12664219
references.citation: Crit Care Med. 2010 Feb;38(2):367-74
references.pmid: 20035219
references.citation: Am J Public Health. 2010 Nov;100(11):2279-87
references.pmid: 20864721
references.citation: Crit Care Med. 2011 Jun;39(6):1306-12
references.pmid: 21336115
references.citation: Health Stat Q. 2006 Summer;(30):6-14
references.pmid: 16759077
references.citation: Am J Emerg Med. 2012 Jan;30(1):51-6
references.pmid: 21030181
references.citation: Intensive Care Med. 2007 Mar;33(3):435-43
references.pmid: 17225161
references.citation: Crit Care. 2008;12(6):R158
references.pmid: 19091069
references.citation: Crit Care Med. 2008 Apr;36(4):1168-74
references.pmid: 18379243
references.citation: Crit Care Med. 1999 Sep;27(9):1760-7
references.pmid: 10507595
references.citation: Chest. 1992 Jun;101(6):1644-55
references.pmid: 1303622
references.citation: J Neurol Neurosurg Psychiatry. 2005 Apr;76(4):498-502
references.pmid: 15774434
references.citation: N Engl J Med. 2003 Apr 17;348(16):1546-54
references.pmid: 12700374
references.citation: Intensive Care Med. 2011 Mar;37(3):444-52
references.pmid: 21152895
references.citation: Crit Care. 2009;13(1):R28
references.pmid: 19250547