Differential brain effects of laser and needle acupuncture at LR8 using functional MRI.
OBJECTIVE
While needle acupuncture is a well-accepted technique, laser acupuncture is being increasingly used in clinical practice. The differential effects of the two techniques are of interest. We examine this in relation to brain effects of activation of LR8, a putative acupuncture point for depression, using functional MRI (fMRI).


METHODS
Sixteen healthy participants were randomised to receive low intensity laser acupuncture to LR8 on one side and needle acupuncture to the contralateral LR8. Stimulation was in an on-off block design and brain patterns were recorded under fMRI.


RESULTS
Significant activation occurred in the left precuneus during laser acupuncture compared with needle acupuncture and significant activation occurred in the left precentral gyrus during needle acupuncture compared with laser acupuncture.


CONCLUSIONS
Laser and needle acupuncture at LR8 in healthy participants produced different brain patterns. Laser acupuncture activated the precuneus relevant to mood in the posterior default mode network while needle acupuncture activated the parietal cortical region associated with the primary motor cortex. Further investigations are warranted to evaluate the clinical relevance of these effects.
School of Psychiatry, University of New South Wales and Neuropsychiatric Institute NPI, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Im
I
Quah-Smith
Mark A
MA
Williams
Thomas
T
Lundeberg
Chao
C
Suo
Perminder
P
Sachdev
D015669:Acupuncture Points; D015670:Acupuncture Therapy / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000339:Affect; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007834:Lasers; D008027:Light; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009339:Needles; D055815:Young Adult