Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.
Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.
Human Vaccine Institute.
Carrie
C
Ho
Steven
S
Wu
Joshua D
JD
Amos
Lisa
L
Colvin
Shannon D
SD
Smith
Andrew B
AB
Wilks
C Todd
CT
Demarco
Christie
C
Brinkley
Thomas N
TN
Denny
Joern E
JE
Schmitz
Allen G
AG
Rodrigo
Sallie R
SR
Permar
D000818:Animals; D002522:Chlorocebus aethiops; D016000:Cluster Analysis; D005260:Female; D015686:Gene Products, env / Q000235:genetics; D014644:Genetic Variation; D008895:Milk, Human / Q000821:virology*; D010802:Phylogeny; D010949:Plasma / Q000821:virology; D017422:Sequence Analysis, DNA; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*
D015686:Gene Products, env