Gradual and stepwise increase of blood pressure in hemorrhagic shock: Mimicking ischemic post-conditioning.
Hemorrhagic shock, and subsequent resuscitation leads to global ischemia/reperfusion injury. It may result in multiple organ injury and death. Ischemic post-conditioning has been suggested to reduce organ injury. It may lead to gradual increase in tissue oxygen delivery and tissue acidosis may be reduced gradually. Gradual increase of blood pressure or blood flow in ischemic organs has been reported to decrease tissue injury. We propose that gradual and stepwise increase of blood pressure may decrease tissue injury and mortality in hemorrhagic shock by mimicking ischemic post-conditioning.
Department of Emergency Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
Jae Hyuk
JH
Lee
Kyuseok
K
Kim
You Hwan
YH
Jo
Kyeong Won
KW
Kang
Joong Eui
JE
Rhee
Chan Jong
CJ
Park
Joonghee
J
Kim
Heajin
H
Chung
D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods*; D008954:Models, Biological; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy