Identifying the default mode network structure using dynamic causal modeling on resting-state functional magnetic resonance imaging.
The default mode network is part of the brain structure that shows higher neural activity and energy consumption when one is at rest. The key regions in the default mode network are highly interconnected as conveyed by both the white matter fiber tracing and the synchrony of resting-state functional magnetic resonance imaging signals. However, the causal information flow within the default mode network is still poorly understood. The current study used the dynamic causal modeling on a resting-state fMRI data set to identify the network structure underlying the default mode network. The endogenous brain fluctuations were explicitly modeled by Fourier series at the low frequency band of 0.01-0.08Hz, and those Fourier series were set as driving inputs of the DCM models. Model comparison procedures favored a model wherein the MPFC sends information to the PCC and the bilateral inferior parietal lobule sends information to both the PCC and MPFC. Further analyses provide evidence that the endogenous connectivity might be higher in the right hemisphere than in the left hemisphere. These data provided insight into the functions of each node in the DMN, and also validate the usage of DCM on resting-state fMRI data.
Department of Radiology, UMDNJ-New Jersey Medical School, Newark, NJ, USA.
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Department of Radiology, UMDNJ-New Jersey Medical School, Newark, NJ, USA. Electronic address: bbiswal@yahoo.com.
Bharat B
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Biswal
D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D015203:Reproducibility of Results; D012146:Rest / Q000502:physiology*; D012680:Sensitivity and Specificity; D055815:Young Adult
BMS; Bayesian Model Selection; DCM; DMN; Default Mode Network; Default-mode network; Dynamic Causal Model; Dynamic causal model; FDR; False Discovery Rate; Fourier series; GCA; GLM; General Linear Model; Granger Causality Analysis; ICA; IPL; Independent Component Analysis; Inferior Parietal Lobule; LFF; Low-frequency Fluctuation; Low-frequency fluctuation; MNI; MPFC; Medial Prefrontal Cortex; Montreal Neurological Institute; PCC; Posterior Cingulate Cortex; ROI; Region of Interest; Resting-state; SEM; Structure Equation Model; fMRI; functional Magnetic Resonance Imaging