Degraded limonoids and quinoline alkaloids from Dictamnus angustifolius G. Don ex Sweet. and their anti-platelet aggregation activity.
A new degraded limonoid, named isodictamdiol A (1), two known degraded limonoids (2, 3) and a new nature product of quinoline alkaloid (4) along with five known quinoline alkaloids (5-9) were isolated from the root bark of Dictamnus angustifolius G. Don ex Sweet.. Certain useful NMR data were generalized to determine the structures of compounds 1 and 4. The structural elucidation of Compound 4 was first reported herein. Compounds 1-9 showed significant inhibitory effects on platelet aggregation induced by ADP at 250 μM, while Compound 4 showed potent anti-platelet aggregation activity.
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Jian-Bo
JB
Sun
Wei
W
Qu
Pei
P
Wang
Fei-Hua
FH
Wu
Li-Ying
LY
Wang
Jing-Yu
JY
Liang
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D036905:Dictamnus / Q000737:chemistry*; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits
D036701:Limonins; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D011804:Quinolines; C000588612:isodictamdiol A
Anti-platelet aggregation activity; Degraded limonoids; Dictamnus angustifolius G. Don ex Sweet.; Quinoline alkaloids