Neural basis of semantic and syntactic interference in sentence comprehension.
According to the cue-based parsing approach (Lewis, Vasishth, & Van Dyke, 2006), sentence comprehension difficulty derives from interference from material that partially matches syntactic and semantic retrieval cues. In a 2 (low vs. high semantic interference)×2 (low vs. high syntactic interference) fMRI study, greater activation was observed in left BA44/45 for high versus low syntactic interference conditions following sentences and in left BA45/47 for high versus low semantic interference conditions following comprehension questions. A conjunction analysis showed BA45 associated with both types of interference, while BA47 was associated with only semantic interference. Greater activation was also observed in the left STG in the high interference conditions. Importantly, the results for the LIFG could not be attributed to greater working memory capacity demands for high interference conditions. The results favor a fractionation of the LIFG wherein BA45 is associated with post-retrieval selection and BA47 with controlled retrieval of semantic information.
University of Michigan, Department of Psychiatry and Addiction Research Center, 4250 Plymouth Road, Ann Arbor, MI 48109, United States.
Yi G
YG
Glaser
Randi C
RC
Martin
Julie A
JA
Van Dyke
A Cris
AC
Hamilton
Yingying
Y
Tan
D001931:Brain Mapping; D032882:Comprehension / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D012660:Semantics
Interference; Left inferior frontal gyrus; Sentence comprehension; Working memory; fMRI