Heme-based globin-coupled oxygen sensors: linking oxygen binding to functional regulation of diguanylate cyclase, histidine kinase, and methyl-accepting chemotaxis.
An emerging class of novel heme-based oxygen sensors containing a globin fold binds and senses environmental O2 via a heme iron complex. Structure-function relationships of oxygen sensors containing a heme-bound globin fold are different from those containing heme-bound PAS and GAF folds. It is thus worth reconsidering from an evolutionary perspective how heme-bound proteins with a globin fold similar to that of hemoglobin and myoglobin could act as O2 sensors. Here, we summarize the molecular mechanisms of heme-based oxygen sensors containing a globin fold in an effort to shed light on the O2-sensing properties and O2-stimulated catalytic enhancement observed for these proteins.
From the Department of Biochemistry, Faculty of Science, Charles University in Prague, 128 43 Prague 2, Czech Republic.
Markéta
M
Martínková
Kenichi
K
Kitanishi
Toru
T
Shimizu
D000595:Amino Acid Sequence; D016948:Azotobacter vinelandii / Q000201:enzymology; D001665:Binding Sites; D001886:Bordetella pertussis / Q000201:enzymology; D002384:Catalysis; D020134:Catalytic Domain; D002633:Chemotaxis; D004926:Escherichia coli / Q000201:enzymology; D029968:Escherichia coli Proteins / Q000737:chemistry*; D019143:Evolution, Molecular; D015971:Gene Expression Regulation, Enzymologic; D005914:Globins / Q000737:chemistry*; D006418:Heme / Q000737:chemistry*; D006454:Hemoglobins / Q000737:chemistry; D000071677:Histidine Kinase; D008969:Molecular Sequence Data; D009211:Myoglobin / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry*; D019761:Phosphorus-Oxygen Lyases / Q000737:chemistry*; D011485:Protein Binding; D011494:Protein Kinases / Q000737:chemistry; D017386:Sequence Homology, Amino Acid
D029968:Escherichia coli Proteins; D006454:Hemoglobins; D009211:Myoglobin; D006418:Heme; D005914:Globins; D011494:Protein Kinases; D000071677:Histidine Kinase; D019761:Phosphorus-Oxygen Lyases; C060720:diguanylate cyclase; D010100:Oxygen
Chemotaxis; Cyclic GMP (cGMP); Heme; Hemoglobin; Histidine Kinases; Myoglobin; Oxygen Binding