Fragile X syndrome: an aging perspective.
Cognitive and behavioral correlates of molecular variations related to the FMR1 gene have been studied rather extensively, but research about the long-term outcome in individuals with fragile X spectrum disorders remains sparse. In this review, we present an overview of aging research and recent findings in regard to cellular and clinical manifestations of aging in fragile X syndrome, and the FMR1 premutation.
MIND Institute, University of California at Davis Medical Center, Sacramento, California, USA. andrea.schneider@ucdmc.ucdavis.edu
Andrea
A
Schneider
Andrew
A
Ligsay
Randi J
RJ
Hagerman
D000375:Aging / Q000235:genetics / Q000378:metabolism; D002526:Cerebellar Diseases / Q000235:genetics / Q000503:physiopathology; D002659:Child Development Disorders, Pervasive / Q000150:complications / Q000503:physiopathology; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics / Q000378:metabolism*; D005600:Fragile X Syndrome / Q000235:genetics* / Q000523:psychology; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics / Q000503:physiopathology; D009030:Mosaicism
D051860:Fragile X Messenger Ribonucleoprotein 1; C497683:FMR1 protein, human
FMRP; aging; fragile X syndrome; neurodegeneration