The essential nature of iron usage and regulation.
The facile ability of iron to gain and lose electrons has made iron an important participant in a wide variety of biochemical reactions. Binding of ligands to iron modifies its redox potential, thereby permitting iron to transfer electrons with greater or lesser facility. The ability to transfer electrons, coupled with its abundance, as iron is the fourth most abundant mineral in the earth's crust, have contributed to iron being an element required by almost all species in the six kingdoms of life. Iron became an essential element for both Eubacteria and Archeabacteria in the early oxygen-free stages of the earth's evolution. With the advent of an oxygen-rich environment, the redox properties of iron made it extremely useful, as much of iron utilization in eukaryotes is focused on oxygen metabolism, either as an oxygen carrier or as an electron carrier that can facilitate oxygen-based chemistry.
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. jerry.kaplan@path.utah.edu
Jerry
J
Kaplan
Diane M
DM
Ward
D000818:Animals; D001419:Bacteria / Q000378:metabolism; D005075:Biological Evolution; D001692:Biological Transport; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D006420:Hemeproteins / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000737:chemistry / Q000378:metabolism; D015388:Organelles / Q000378:metabolism; D014714:Vertebrates / Q000378:metabolism
D004798:Enzymes; D006420:Hemeproteins; D007506:Iron-Sulfur Proteins; D007501:Iron