Colonic neuropathology is independent of olfactory dysfunction in Parkinson's disease.
Olfactory dysfunction (OD) and constipation are two frequent and early non-motor features of Parkinson's disease (PD). Colonic PD neuropathology, the putative cause of constipation, can be analyzed and quantified using routine colonic biopsies and parallels disease severity. The present study was aimed at investigating whether the severity of neuropathology in the colon in PD is related to OD. Twenty-six PD patients were included. Colonic neuropathology, i.e., the density of Lewy pathology and the number of submucosal neurons, was unrelated to OD as assessed using the University of Pennsylvania Smell Identification. This suggests that unlike colonic Lewy pathology, OD is unrelated to disease severity.
Inserm, U913, Nantes, France.
Thibaud
T
Lebouvier
Hélène
H
Pouclet
Emmanuel
E
Coron
Anne
A
Drouard
Jean-Michel
JM
N'Guyen
Monica
M
Roy
Fabienne
F
Vavasseur
Stanislas
S
Bruley des Varannes
Philippe
P
Damier
Michel
M
Neunlist
Pascal
P
Derkinderen
Tiphaine
T
Rouaud
D000368:Aged; D003106:Colon / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000378:metabolism; D009474:Neurons / Q000473:pathology*; D000857:Olfaction Disorders / Q000209:etiology*; D010300:Parkinson Disease / Q000150:complications* / Q000473:pathology*; D012903:Smell / Q000502:physiology*; D051844:alpha-Synuclein / Q000378:metabolism
D016900:Neurofilament Proteins; D051844:alpha-Synuclein; C051774:neurofilament protein H