[Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus].
The authors' data and those from literature concerning biological role of fetuin A glycoprotein have been generalized in the article. A direct correlation has been established between fetuin A and some adipokines involved in the formation of insulin resistance and atherogenesis (progranulin, omentin-1), and osteoprotegerin (the novel cardiovascular risk factor) as well as an increase of circulating levels of fetuin A in patients with type 2 diabetes mellitus with high cardiovascular risk metabolic pattern but without manifestations of macrovascular complications. This substantiates the involvement of fetuin A in the complex of biomarkers of subclinical atherosclerosis.
M Iu
MIu
Horshuns'ka
Iu I
IuI
Karachentsev
N O
NO
Kravchun
É
É
Ĭensen
Zh A
ZhA
Leshchenko
O I
OI
Hladkykh
N S
NS
Krasova
T V
TV
Tyzhnenko
Iu A
IuA
Opaleĭko
V V
VV
Poltorak
D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000235:genetics; D016207:Cytokines / Q000097:blood* / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000235:genetics; D058851:GPI-Linked Proteins / Q000097:blood / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000235:genetics; D037102:Lectins / Q000097:blood* / Q000235:genetics; D053244:Osteoprotegerin / Q000097:blood* / Q000235:genetics; D000077153:Progranulins; D012307:Risk Factors; D060749:alpha-2-HS-Glycoprotein / Q000235:genetics / Q000378:metabolism*
D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C492314:GRN protein, human; C432397:ITLN1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D037102:Lectins; D053244:Osteoprotegerin; D000077153:Progranulins; D060749:alpha-2-HS-Glycoprotein