Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics.
RNAi-based nucleic acid molecules have attracted considerable attention as compelling therapeutics providing safe and competent delivery systems are available. Dendrimers are emerging as appealing nanocarriers for nucleic acid delivery thanks to their unique well-defined architecture and the resulting cooperativity and multivalency confined within a nanostructure. The present review offers a brief overview of the structurally flexible triethanolamine-core poly(amidoamine) (PAMAM) dendrimers developed in our group as nanovectors for the delivery of RNAi therapeutics. Their excellent activity for delivering different RNAi therapeutics in various disease models in vitro and in vivo will be highlighted here.
Centre de Recherche en Cancérologie de Marseille, Inserm, UMR1068, 13009 Marseille, France; Institut Paoli-Calmettes, 13009 Marseille, France; Aix-Marseille Université, 13284 Marseille, France; CNRS, UMR7258, 13009 Marseille, France.
Xiaoxuan
X
Liu
Aix-Marseille Université, Centre Interdisciplinaire de Nanoscience de Marseille, CNRS UMR 7325, 163, avenue de Luminy, 13288 Marseille, France; College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan, P. R. China.
Cheng
C
Liu
Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH-6500 Bellinzona, Switzerland.
Carlo V
CV
Catapano
Aix-Marseille Université, Centre Interdisciplinaire de Nanoscience de Marseille, CNRS UMR 7325, 163, avenue de Luminy, 13288 Marseille, France. Electronic address: ling.peng@univ-amu.fr.
Ling
L
Peng
Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA, USA.
Jiehua
J
Zhou
Centre de Recherche en Cancérologie de Marseille, Inserm, UMR1068, 13009 Marseille, France; Institut Paoli-Calmettes, 13009 Marseille, France; Aix-Marseille Université, 13284 Marseille, France; CNRS, UMR7258, 13009 Marseille, France. Electronic address: palma.rocchi@inserm.fr.
Palma
P
Rocchi
D000818:Animals; D050091:Dendrimers / Q000737:chemistry*; D004983:Ethanolamines / Q000737:chemistry*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D050997:Nanomedicine / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*; D011073:Polyamines / Q000737:chemistry*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism
D050091:Dendrimers; D004983:Ethanolamines; D035683:MicroRNAs; C104700:PAMAM Starburst; C531249:Poly(amidoamine); D011073:Polyamines; D034741:RNA, Small Interfering; C009546:triethanolamine
Dendrimer; Gene silencing; Nanovector; RNA interference; RNAi therapeutics