Hemophagocytic lymphohistiocytosis after allogeneic bone marrow transplantation during chronic norovirus infection.
Hemophagocytic lymphohistiocytosis (HLH) is a macrophage activating syndrome that is known to develop in patients with autoimmune disease, malignancies or infection, for example with Epstein-Barr virus, cytomegalovirus or varicella zoster virus. We describe a 24-month old boy with acute myelogenous leukaemia relapse and allogeneic bone marrow transplantation, who developed HLH on day +40 during chronic infection with norovirus. Here, we report for the first time the development of HLH in combination with chronic norovirus infection after allogeneic bone marrow transplantation in a hematopoietic malignancy.
Department of Pediatrics I, Division of Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria.
Christina
C
Salvador
Bernhard
B
Meister
Heike
H
Larcher
Roman
R
Crazzolara
Gabriele
G
Kropshofer
D017250:Caliciviridae Infections / Q000150:complications*; D002908:Chronic Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000821:virology; D008297:Male; D029322:Norovirus / Q000302:isolation & purification*; D016896:Treatment Outcome
childhood cancer; hematopoietic stem cell transplantation; hemophagocytic lymphohistiocytosis; norovirus