One-pot synthesis of ferrocenyl ketones containing biaryls and 6-aryl-2-ferrocenylquinolines via Ir/Pd-cocatalyzed α-alkylation/Suzuki reaction.
An efficient PPh3-cyclometalated iridium(III) benzo[h]quinoline hydride 1/Pd(OAc)2-cocatalyzed three-component α-alkylation/Suzuki reaction has been developed. The three-component reaction of 4-bromobenzyl alcohol, acetylferrocene, and arylboronic acids gives ferrocenyl ketones containing biaryls in moderate to good yields. This method was successfully applied to a one-pot synthesis of 6-aryl-2-ferrocenyl quinolines, using (2-amino-5-bromophenyl)methanol instead of 4-bromobenzyl alcohol.
College of Chemistry, Chemical Engineering, Luoyang Normal University, Luoyang, Henan 471022, China. xubohan@163.com
Chen
C
Xu
Xin-Qi
XQ
Hao
Zhi-Qiang
ZQ
Xiao
Zhi-Qiang
ZQ
Wang
Xiao-Er
XE
Yuan
Wei-Jun
WJ
Fu
Bao-Ming
BM
Ji
Mao-Ping
MP
Song
D000478:Alkylation; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D000075163:Metallocenes; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
D005296:Ferrous Compounds; D007659:Ketones; D000075163:Metallocenes; D009942:Organometallic Compounds; D011804:Quinolines; D007495:Iridium; D010165:Palladium; C004998:ferrocene