Lymphoplasmacyte-rich meningioma: our experience with 19 cases and a systematic literature review.
OBJECTIVE
To investigate the clinicopathological characteristics, prognosis, pathology, and differential diagnosis of LPM by analyzing our experience and reviewed relevant literature. We also postulated the necessity of postoperative adjuvant therapy.


METHODS
19 patients with LPM underwent surgical treatment from 2007 through 2010 in our department. The clinical charts of the patients, including surgical, histological, and follow-up records, as well as imaging studies, were analyzed retrospectively. Other 43 cases searched from the literature were also included, so that 62 LPM cases were summarized and reviewed together.


RESULTS
The summarized 62 patients comprised 30 males and 31 females aged 9 years to 79 years (40.7±18.3 years). The most common locations were convexity, skull base, para-sagittal and cervical canal. Multiple or diffuse lesions were found in 8 cases. There were 13 patients had peripheral blood abnormalities (21%). One-third of the cases had moderate to severe peritumoral brain edema. Thirty-eight patients had total resection, 12 patients not specified while 12 received subtotal resection or only biopsy. MIB-1 was available in 24 cases and a third of them were higher than 3%. Follow-up more than 3 year was only completed in 19/62 cases. Seven cases suffered recurrence and two of them died after 2 years of operation.


CONCLUSIONS
LPM is a very rare benign variant of intracranial meningioma. Both lesions and hematological abnormalities have a predilection for younger individuals. Preoperative diagnosis of this subtype of meningioma is still difficult. Surgical resection is the primary treatment option, and supportive care for those not totally removed is very important, because the recurrence rate for this subtype is rather low. However, the massive infiltration of lymphocytes and plasma cells in LPMs are still controversial and the long-term follow-ups are needed. Radiotherapy is not recommended, and hormonal or immune-inhibitor therapy might be helpful.
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University Shanghai, China.
Hong-Da
HD
Zhu
Qing
Q
Xie
Ye
Y
Gong
Ying
Y
Mao
Ping
P
Zhong
Feng-Ping
FP
Hang
Hong
H
Chen
Ming-Zhe
MZ
Zheng
Hai-Liang
HL
Tang
Dai-Jun
DJ
Wang
Xian-Cheng
XC
Chen
Liang-Fu
LF
Zhou
Diagnosis; differential diagnosis; edema; lymphoplasmacyte-rich meningioma; prognosis