Hyperthermia-induced seizures: development of hyperthermia-prone and hyperthermia-resistant rats.
Febrile seizures (FS), as a multifactorial and genetic disease, are the most common type of convulsive event in infants and young children. Their genetic basis, however, remains elusive. To investigate the genetic mechanisms involved in FS and to identify novel susceptibility genes, we developed two new strains of rats that are hyperthermia-prone (HP, lower seizure threshold) and hyperthermia-resistant (HR, higher seizure threshold) using an established model of hyperthermia-induced seizures combined with selective breeding process. With each subsequent generation, the morbidity of the FS gradually increased in the HP group and gradually decreased in the HR group. Changes in seizure susceptibility between the two genotypes were investigated using kainic acid (KA)-induced seizures and electroencephalography (EEG). The HP rats had a greater seizure severity compared with the HR rats. Our findings may be a significant step toward discovering the genetic mechanisms involved in FS and may elucidate the pathogenesis of this disorder.
Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
Jian
J
Xu
Yuanteng
Y
Fan
Liang
L
Li
Yanyan
Y
Qiu
Zhongcheng
Z
Wang
Song
S
Han
Jun
J
Yin
Wanhong
W
Liu
Biwen
B
Peng
Xiaohua
X
He
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D001947:Breeding; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D018690:Excitatory Amino Acid Agonists; D005334:Fever / Q000235:genetics* / Q000503:physiopathology*; D007608:Kainic Acid; D010375:Pedigree; D051381:Rats; D017207:Rats, Sprague-Dawley; D003294:Seizures, Febrile / Q000139:chemically induced / Q000235:genetics* / Q000503:physiopathology*; D013045:Species Specificity
D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid
EEG; Epilepsy; FS; Febrile seizures; Genetic model; HP; HR; Hyperthermia; KA; Kainic acid; electroencephalography; febrile seizures; hyperthermia-prone; hyperthermia-resistant; kainic acid