Assessing the dual activity of a chalcone-phthalocyanine conjugate: design, synthesis, and antivascular and photodynamic properties.
Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.
Department of Chemistry, Gebze Institute of Technology , P.O. Box 141, 41400 Gebze, Kocaeli, Turkey.
Sinem
S
Tuncel
Aurélien
A
Trivella
Devrim
D
Atilla
Khalil
K
Bennis
Huguette
H
Savoie
Florian
F
Albrieux
Laetitia
L
Delort
Hermine
H
Billard
Virginie
V
Dubois
Vefa
V
Ahsen
Florence
F
Caldefie-Chézet
Claire
C
Richard
Ross W
RW
Boyle
Sylvie
S
Ducki
Fabienne
F
Dumoulin
D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D002599:Chalcone / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D054833:Isoindoles; D015394:Molecular Structure; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000378:metabolism
D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D002599:Chalcone; C013647:phthalocyanine