Leptin to adiponectin ratio in preeclampsia.
The aim of the present study was to assess leptin/adiponectin ratio in preeclamptic patients compared with normal pregnant women. A cross-sectional study was designed. The study population consisted of 30 preeclamptic patients and 30 healthy pregnant women. Serum levels of total leptin and adiponectin were assessed using commercially available enzyme-linked immunosorbent assay methods. The one-way ANOVA and Student's t tests and Pearson's correlation analysis were used for statistical calculations. Levels of leptin and adiponectin were also adjusted for BMI. A p-value < 0.05 was considered statistically significant. The leptin/adiponectin ratio was increased significantly in preeclamptic patients. The leptin/adiponectin ratio was significantly higher in severe preeclamptic patient than in mild preeclampsia. Adjusted leptin/adiponectin ratio was also significantly increased in preeclamptic patients than in normal pregnant women. The findings of the present study suggest that the leptin/adiponectin ratio was increased in preeclamsia and imbalance between the adipocytokines could be involved in the pathogenesis of preeclampsia.
School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. khosrowbeygi@yahoo.com
A
A
Khosrowbeygi
H
H
Ahmadvand
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000704:Analysis of Variance; D001459:Bangladesh; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
D052242:Adiponectin; D020738:Leptin