Immunological profile of HTLV-1-infected patients associated with infectious or autoimmune dermatological disorders.
In the present study, the frequency, the activation and the cytokine and chemokine profile of HTLV-1 carriers with or without dermatological lesions were thoroughly described and compared. The results indicated that HTLV-1-infected patients with dermatological lesions have distinct frequency and activation status when compared to asymptomatic carriers. Alterations in the CD4(+)HLA-DR(+), CD8(+) T cell, macrophage-like and NKT subsets as well as in the serum chemokines CCL5, CXCL8, CXCL9 and CXCL10 were observed in the HTLV-1-infected group with skin lesions. Additionally, HTLV-1 carriers with dermatological skin lesions showed more frequently high proviral load as compared to asymptomatic carriers. The elevated proviral load in HTLV-1 patients with infectious skin lesions correlated significantly with TNF-α/IL-10 ratio, while the same significant correlation was found for the IL-12/IL-10 ratio and the high proviral load in HTLV-1-infected patients with autoimmune skin lesions. All in all, these results suggest a distinct and unique immunological profile in the peripheral blood of HTLV-1-infected patients with skin disorders, and the different nature of skin lesion observed in these patients may be an outcome of a distinct unbalance of the systemic inflammatory response upon HTLV-1 infection.
Laboratório de Biomarcadores de Diagnóstico e Monitoração, Instituto René Rachou, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil.
Jordana Grazziela Alves
JG
Coelho-dos-Reis
Livia
L
Passos
Mariana Costa
MC
Duarte
Marcelo Grossi
MG
Araújo
Ana Carolina
AC
Campi-Azevedo
Andréa
A
Teixeira-Carvalho
Vanessa
V
Peruhype-Magalhães
Bruno Caetano
BC
Trindade
Raquel
R
Dos Santos Dias
Marina Lobato
ML
Martins
Anna Barbara de Freitas
AB
Carneiro-Proietti
Antônio Carlos
AC
Guedes
Denise Utsch
DU
Gonçalves
Olindo Assis
OA
Martins-Filho
D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications*; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology; D005260:Female; D015490:HTLV-I Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000150:complications*; D019562:Viral Load