TGF-β antagonists: same knot, but different hold.
In this issue of Structure, Nolan and colleagues present the structure of BMP antagonist, PRDC, which adopts a head-to-tail dimer with distinct structure and inhibitory mechanism compared to other dimeric antagonists of the TGF-β superfamily, such as noggin.
Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA. hinck@uthscsa.edu
Andrew P
AP
Hinck
Tao
T
Huang
D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000737:chemistry*; D016207:Cytokines; D011506:Proteins / Q000737:chemistry*
C525719:Bmp2 protein, mouse; D055396:Bone Morphogenetic Protein 2; D016207:Cytokines; C490088:Grem2 protein, mouse; D011506:Proteins