[Analyses on the relative factors regarding diabetic nephropathy].
OBJECTIVE
To analyze the related factors regarding diabetic nephropathy (DN).


METHODS
A total number of 756 diabetic patients from 2009 to 2011 were analyzed retrospectively. Three groups were formed according to the urinary albumin excretion rates (UAER). Patients with UAER < 20 µg/min was grouped to group A, with UAER from 20 to 200 µg/min as group B, and the others with UAER ≥ 200 µg/min was grouped to group C. General characteristics and laboratory parameters were then compared and related factors of DN analyzed.


RESULTS
The constituent ratio of nephropathy was 30.2% (228/756). Patient's age, duration of disease, both diastolic and systolic blood pressure of group A were significantly higher than the non-DN group (A) (P < 0.05). Patient's age, disease duration, both diastolic and systolic blood pressure of group C were (64.08 ± 11.71) years, (14.67 ± 7.34) years, (87.43 ± 14.36) mm Hg, (152.45 ± 18.48) mm Hg, respectively, with statistically significant difference (P < 0.05) between group C and group B. FPG, TG, TC, HDL-C, UA, HbA1c, FINS, FCP of group B were (9.27 ± 3.06) mmol/L, (1.98 ± 0.37) mmol/L, (5.01 ± 1.08) mmol/L, (1.05 ± 0.35) mmol/L, (312.78 ± 39.83) mmol/L, (9.33 ± 1.47)%, (11.45 ± 7.83) µU/ml, (509.73 ± 132.78) pmol/L respectively, with significant difference (P < 0.05) between group B and group A. FPG, TG, HDL-C, UA, FINS, FCP of group C were (9.29 ± 3.12) mmol/L, (2.02 ± 0.36) mmol/L, (1.04 ± 0.27) mmol/L, (389.72 ± 46.32) mmol/L, (11.09 ± 8.29) µU/ml, (575.77 ± 143.29) pmol/L respectively, with significant difference (P < 0.05) between group C and group A. UA, FINS, FCP were found with significant differences (P < 0.05) between group C and group B. Data from multivariate logistic regression showed that DNs were related with disease duration, BMI, systolic blood pressure, HbAlc, FPG, UA.


CONCLUSIONS
DN was closely related to the duration, age, blood sugar, blood lipids, blood pressure, uric acid levels of the disease.
Department of Endocrinology of Tianjin Fourth Central Hospital, Tianjin 300140, China.
Hai-lin
HL
Shao
Chun-qing
CQ
Song
Dong-hong
DH
Xu
Xiao-jing
XJ
Shang
Zhao-hu
ZH
Hao
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014527:Uric Acid / Q000378:metabolism
D001786:Blood Glucose; D008055:Lipids; D014527:Uric Acid