Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions.
BACKGROUND
Contrast induced kidney injury is an acute renal dysfunction that is secondary to the administration of radio contrast media. The purpose of this study was to evaluate the levels of urotensin-II (UT-II) and endothelin-I (ET-I) after contrast media administration in patients undergoing percutaneous coronary interventions.


METHODS
In this prospective cohort study, we evaluated 78 patients with coronary artery disease who were scheduled for and ultimately underwent percutaneous coronary interventions. As a contrast material, nonionic contrast media was used in various amounts (70-480 mL). Blood and urine samples were obtained to measure U-II, ET-I just before and at the twenty-fourth hour of percutaneous coronary interventions.


RESULTS
Compared to baseline, twenty-fourth hour creatinine levels were significantly increased (P < 0.001). The twenty-fourth hour serum and urine levels of both UT-II and ET-I were also significantly increased compared to baseline (P < 0.001 for all) and 24(th) hour serum and urine UT-II (r = 0.322, P = 0.004; r = 0.302, P = 0.007 respectively), ET-I (r = 0.511, P < 0.001; r = 0.266, P = 0.019 respectively) levels were significantly correlated with the amount of contrast media.


CONCLUSIONS
Our study indicates that; increased UT-II and ET-I levels seem to be a consequence of hazardous effects of contrast media on blood vessels and the kidney.
Department of Internal Medicine, Harran University, Faculty of Medicine, Sanliurfa, Turkey.
Turgay
T
Ulas
Hakan
H
Buyukhatipoglu
Mehmet S
MS
Dal
Idris
I
Kirhan
Zekeriya
Z
Kaya
Mehmet E
ME
Demir
Irfan
I
Tursun
Mehmet A
MA
Eren
Timucin
T
Aydogan
Yusuf
Y
Sezen
Nurten
N
Aksoy
Acute kidney injury; contrast media; coronary angiography; endothelin-I; urotensin-II