Evidence for continuing cross-species transmission of SIVsmm to humans: characterization of a new HIV-2 lineage in rural Côte d'Ivoire.
HIV types 1 and 2 (HIV-1 and HIV-2) are the result of multiple cross-species transmissions of their simian counterparts (SIVs) to humans. We studied whether new SIVs lineages have been transmitted to humans in rural Côte d'Ivoire and identified a novel HIV-2 variant (HIV-2-07IC-TNP03) not related to any of the previously defined HIV-2 groups. This finding shows that sooty mangabey viruses continue to be transmitted to humans, causing new zoonotic outbreaks.
aUMI 233, IRD and University of Montpellier 1, Montpellier, France bDepartment of Diagnostics, Teaching Hospital, University of Bouake, Côte d'Ivoire cProject group Epidemiology of Highly Pathogenic Microorganisms RKI, Berlin, Germany dDepartment of Microbiology and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ahidjo
A
Ayouba
Chantal
C
Akoua-Koffi
Sébastien
S
Calvignac-Spencer
Amandine
A
Esteban
Sabrina
S
Locatelli
Hui
H
Li
Yingying
Y
Li
Beatrice H
BH
Hahn
Eric
E
Delaporte
Fabian H
FH
Leendertz
Martine
M
Peeters
D000818:Animals; D016665:Cercocebus atys; D007560:Cote d'Ivoire / Q000453:epidemiology; D015658:HIV Infections / Q000235:genetics*; D015498:HIV-2 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D015302:Simian Immunodeficiency Virus / Q000235:genetics*; D015047:Zoonoses / Q000235:genetics