Three-dimensional configuration of subretinal fluid in central serous chorioretinopathy.
OBJECTIVE
The purpose of this study was to characterize the 3-dimensional (3D) configuration of subretinal fluid (SRF) in idiopathic central serous chorioretinopathy (CSC) using spectral-domain optical coherence tomography (SDOCT).


METHODS
The OCT images of patients with CSC were reviewed retrospectively. The 3D configurations of SRF were assessed using a modified segmentation algorithm of SDOCT. The differences of the configurations between acute and chronic CSC were compared. For the patients with acute CSC, we investigated a possible relationship between early change in 3D configuration and disease prognosis.


RESULTS
We included 69 eyes of 68 patients in this study. The mean volume, the greatest basal diameter (GBD), and the area of SRF were not different between acute and chronic CSC. The mean peak height (PH) of SRF and the ratio of PH to GBD in acute CSC (298.13 ± 92.67 μm, 9.44 ± 2.57%) were significantly greater than those in chronic CSC (192.97 ± 71.05 μm, 5.97 ± 1.90%; P < 0.001, P < 0.001, respectively). In patients with acute CSC, the early changing pattern of 3D configurations was significantly different according to the SRF prognosis (P = 0.003). In situ decrease of SRF was observed in 94.7% of the spontaneously resolving group. However, downward elongation of SRF was observed more frequently in the persistent group (58.3%) than in the spontaneously resolving group (6.3%).


CONCLUSIONS
The 3D configurations of SRF were different between acute and chronic CSC. In patients with acute onset, the early change of 3D configuration was different and varied according to the SRF prognosis.
Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Soh-Eun
SE
Ahn
Jaeryung
J
Oh
Jong-Hyun
JH
Oh
In Kyung
IK
Oh
Seong-Woo
SW
Kim
Kuhl
K
Huh
D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D058471:Subretinal Fluid / Q000166:cytology*; D041623:Tomography, Optical Coherence / Q000379:methods*
central serous chorioretinopathy; optical coherence tomography; subretinal fluid; three-dimensional configuration