Obstetrical outcome of young women with a past history of cerebral venous thrombosis.
BACKGROUND
This study was designed to review the obstetrical outcome of a consecutive series of cerebral venous thrombosis (CVT) affecting fertile women over a long period of time.


METHODS
From a computerized database of four hospitals of a French region (Poitou-Charentes), we selected patients admitted to hospital for CVT between January 1995 and February 2012. All the case notes were re-examined by two neurologists to confirm the initial diagnosis of CVT. The criterion of inclusion in our study was the occurrence of CVT in a woman ≤ 40 years of age. All the patients were recontacted by telephone in September 2012 and could be seen in an outpatient clinic. The data of interest were: occurrence of subsequent pregnancies, outcome of these pregnancies, their possible complications, their management with respect to preventive medication, details on the birth and the neonate.


RESULTS
Out of 190 consecutive patients hospitalized for CVT, 62 women aged ≤ 40 years were included (mean age 27.2 ± 6.7 years at the time of their cerebrovascular event). The mean duration of follow-up was 89.5 ± 60.6 months (median: 76 months). There were 45 pregnancies in 24 of the women. Among these 45 pregnancies, 1 was in progress, 24 were completed resulting in normal children, whereas 20 were terminated (5 voluntary abortions, 14 miscarriages and 1 medical abortion). During the pregnancies recorded, there was one recurrence of CVT and no extra-CVT. Various management strategies were adopted, depending on the identified cause(s) for CVT and the medical history of the patient.


CONCLUSIONS
Our study confirms that the occurrence of a CVT in young women is not a contraindication for subsequent pregnancy. However, it points to a high incidence of miscarriage. Apart from this fact, there is no increase in materno-fetal complications during pregnancy and childbirth, and the neonates are healthy. The risk of recurrence of a CVT or extra-CVT during subsequent pregnancy is low but most of patients were on preventive antithrombotic medication.
Department of Neurology, CHU La Milétrie, Poitiers, France.
Jonathan
J
Ciron
Gaëlle
G
Godenèche
Xavier
X
Vandamme
Marie-Pierre
MP
Rosier
Igor
I
Sharov
Stéphane
S
Mathis
Delphine
D
Larrieu
Jean-Philippe
JP
Neau
D000028:Abortion, Induced / Q000706:statistics & numerical data; D000022:Abortion, Spontaneous / Q000453:epidemiology; D000032:Abortion, Therapeutic / Q000706:statistics & numerical data; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000925:Anticoagulants / Q000627:therapeutic use; D002550:Cerebral Veins / Q000473:pathology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D020767:Intracranial Thrombosis / Q000453:epidemiology* / Q000209:etiology; D059906:Neuroimaging; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000235:genetics / Q000517:prevention & control; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D055502:Secondary Prevention; D019851:Thrombophilia / Q000453:epidemiology / Q000235:genetics; D013927:Thrombosis / Q000517:prevention & control; D055815:Young Adult
D000925:Anticoagulants