Stereoselective halocyclization of alkenes with N-acyl hemiaminal nucleophiles.
Halocyclization of alkenes was realized using N-acylhemiaminal nucleophiles. High diastereoselectivity could be achieved for the formation of three stereogenic centers in this halogen-mediated cyclization reaction. We also demonstrated that enantioselective bromocyclization of alkenes using N-acylhemiaminal nucleophiles was possible.
School of Pharmacy, University of Wisconsin, Madison, Wisconsin.
Na
N
Liu
Hao-Yuan
HY
Wang
Wei
W
Zhang
Zhi-Hong
ZH
Jia
Ilia A
IA
Guzei
Hua-Dong
HD
Xu
Weiping
W
Tang
D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D003500:Cyclization; D006219:Halogens / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000475:Alkenes; D000588:Amines; D006219:Halogens
alkene; halocyclization; hemiaminal; stereoselective