The zebrafish as a model for complex tissue regeneration.
For centuries, philosophers and scientists have been fascinated by the principles and implications of regeneration in lower vertebrate species. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues and, in some cases, have served as a guide for contemplating regenerative strategies in mammals. Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs.
Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
Matthew
M
Gemberling
Travis J
TJ
Bailey
David R
DR
Hyde
Kenneth D
KD
Poss
D058500:Animal Fins / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D023421:Models, Animal; D012038:Regeneration; D012160:Retina / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D015027:Zebrafish / Q000235:genetics
brain; fin; heart; regeneration; retina; spinal cord; stem cells; zebrafish