Polymerization-induced self-assembly of galactose-functionalized biocompatible diblock copolymers for intracellular delivery.
Recent advances in polymer science are enabling substantial progress in nanobiotechnology, particularly in the design of new tools for enhanced understanding of cell biology and for smart drug delivery formulations. Herein, a range of novel galactosylated diblock copolymer nano-objects is prepared directly in concentrated aqueous solution via reversible addition-fragmentation chain transfer polymerization using polymerization-induced self-assembly. The resulting nanospheres, worm-like micelles, or vesicles interact in vitro with galectins as judged by a turbidity assay. In addition, galactosylated vesicles are highly biocompatible and allow intracellular delivery of an encapsulated molecular cargo.
Department of Chemistry, University of Sheffield , Brook Hill, Sheffield, South Yorkshire, S3 7HF, United Kingdom.
Vincent
V
Ladmiral
Mona
M
Semsarilar
Irene
I
Canton
Steven P
SP
Armes
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D002470:Cell Survival; D002478:Cells, Cultured; D016503:Drug Delivery Systems; D005690:Galactose / Q000737:chemistry*; D006801:Humans; D008823:Micelles; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*
D001672:Biocompatible Materials; D008823:Micelles; D011108:Polymers; D005690:Galactose