Stabilizing effect of electrostatic vs. aromatic interactions in diproline nucleated peptide β-hairpins.
The contribution of Tyr-His vs. Cys-His interacting pairs to the scaffold stability of (D)Pro-(L)Pro nucleated peptide β-hairpins has been examined. We present direct evidence for the superiority of the Cys-His pairs, mediated by sulphur-imidazole interactions, as added stabilizing agents of the β-hairpin scaffold.
Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India. maha@iiserb.ac.in.
Kamlesh Madhusudan
KM
Makwana
Srinivasarao
S
Raghothama
Radhakrishnan
R
Mahalakshmi
D000595:Amino Acid Sequence; D007093:Imidazoles / Q000737:chemistry; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011392:Proline / Q000031:analogs & derivatives*; D017433:Protein Structure, Secondary; D055672:Static Electricity; D013455:Sulfur / Q000737:chemistry
D007093:Imidazoles; D010455:Peptides; D013455:Sulfur; C029899:imidazole; D011392:Proline