Multi-institutional validation of a preoperative scoring system which predicts survival for patients with glioblastoma.
Glioblastoma is the most common and aggressive type of primary brain tumor in adults. Average survival is approximately 1 year, but individual survival is heterogeneous. Using a single institutional experience, we have previously identified preoperative factors associated with survival and devised a prognostic scoring system based on these factors. The aims of the present study are to validate these preoperative factors and verify the efficacy of this scoring system using a multi-institutional cohort. Of the 334 patients in this study from three different institutions, the preoperative factors found to be negatively associated with survival in a Cox analysis were age >60 years (p<0.0001), Karnofsky Performance Scale score ≤80 (p=0.03), motor deficit (p=0.02), language deficit (p=0.04), and periventricular tumor location (p=0.04). Patients possessing 0-1, 2, 3, and 4-5 of these variables were assigned a preoperative grade of 1, 2, 3, and 4, respectively. Patients with a preoperative grade of 1, 2, 3, and 4 had a median survival of 17.9, 12.3, 10, and 7.5 months, respectively. Survival of each of these grades was statistically significant (p<0.05) in log-rank analysis. This grading system, based only on preoperative variables, may provide patients and physicians with prognostic information that may guide medical and surgical therapy before any intervention is pursued.
Johns Hopkins University, Neuro-Oncology Outcomes Laboratory, 600 North Wolfe Street, Meyer 8-184, Baltimore, MD 21202, USA. Electronic address: Kaisorn@jhmi.edu.
Kaisorn L
KL
Chaichana
Courtney
C
Pendleton
Lola
L
Chambless
Joaquin
J
Camara-Quintana
Jay K
JK
Nathan
Laila
L
Hassam-Malani
Gordon
G
Li
Griffith R
GR
Harsh
Reid C
RC
Thompson
Michael
M
Lim
Alfredo
A
Quinones-Hinojosa
D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality* / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D005909:Glioblastoma / Q000401:mortality* / Q000601:surgery*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011379:Prognosis; D015203:Reproducibility of Results; D016896:Treatment Outcome
Glioblastoma; Prognosis; Scoring system; Surgery; Survival