Healing effects of Aegle marmelos (L.) Correa fruit extract on experimental colitis.
Graded doses of 50% ethanolic extract of dried fruit pulp of Aegle marmelos (AME) (100, 200 and 400 mg/kg) daily for 14 days in acetic acid (AA)-induced colitis in rats showed 200 mg/kg of AME as an optimal effective dose against AA-induced colonic damage score and weight. This dose (200 mg/kg; po) was further studied in AA-induced colitis for its effects on various physical (mucous/blood in stool, food and water intake and body weight changes), histology, antibacterial activity and biochemical parameters like free radicals (nitric oxide and lipid peroxidation), antioxidants (superoxide dismutase, catalase and reduced glutathione) and myeloperoxidase (acute-inflammatory marker) activities in rat colonic tissue. AME decreased colonic mucosal damage and inflammation (macroscopic and microscopic), mucous/bloody diarrhea, fecal frequency and increased body weight affected in AA-induced colitis. AME showed significant antibacterial activity and enhanced the antioxidants but decreased free radicals and myeloperoxidase activities thereby decreasing tissue damage and inflammation and thus, affording ulcer healing. The above effects of A. marmelos authenticated its use in indigenous system of Medicine.
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.
M K
MK
Gautam
R R
RR
Ghatule
A
A
Singh
V
V
Purohit
M
M
Gangwar
Mohan
M
Kumar
R K
RK
Goel
D045471:Aegle / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003092:Colitis / Q000188:drug therapy* / Q000473:pathology*; D003106:Colon / Q000187:drug effects / Q000473:pathology; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D005638:Fruit / Q000737:chemistry*; D008297:Male; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005609:Free Radicals; D010936:Plant Extracts