A derivative of ascorbic acid modulates cAMP production.
We reported, in previous experiments, that AA is a global regulator of cAMP pools. In this study, we demonstrate that K873, an analog of AA we synthesized and presenting antiproliferative properties, has also an impact on cAMP production. However, K873 has no antioxidant activity, at the contrary of AA. It definitively demonstrates that action of AA on the cAMP production is not linked to antioxidant activity. These data suggest that AA, and derivatives of this molecule, could be promising drug acting on biological processes that are under the control of cAMP dependent pathway.
N.O.R.T.: Nutrition, Obesity and Risk of Thrombosis, Aix-Marseille University, INSERM U 1062, INRA 1260, 27 boulevard Jean Moulin, F-13385 Marseille, France.
B
B
Bordignon
S
S
Mones
F
F
Rahman
J
J
Chiron
F
F
Peiretti
N
N
Vidal
M
M
Fontes
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation; D000242:Cyclic AMP / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009185:Myelin Proteins / Q000378:metabolism; D009924:Organ Culture Techniques / Q000379:methods; D010755:Organophosphates / Q000494:pharmacology*; D051381:Rats; D012583:Schwann Cells / Q000166:cytology; D012584:Sciatic Nerve / Q000378:metabolism; D019207:beta Carotene / Q000378:metabolism
D000975:Antioxidants; C584315:K873 compound; D009185:Myelin Proteins; D010755:Organophosphates; C489545:Pmp22 protein, mouse; C489546:Pmp22 protein, rat; D019207:beta Carotene; D000242:Cyclic AMP; D001205:Ascorbic Acid
Antioxidants; Ascorbic acid; Cyclic AMP