[A case of portal vein thrombosis during chemotherapy for bladder cancer].
A 53-year-old man was diagnosed with bladder cancer with pelvic and para-aortic lymph node metastases. The clinical stage was cT3bN2M1. He underwent radical cystectomy and ileal conduit construction and retroperitoneal lymph node dissection after showing a partial response to 4 cycles of chemotherapy with methotrexate,vinblastine,doxorubicin and cisplatin (MVAC). Pathology showed prostatic invasion and para-caval lymph node metastasis. Pathological stage was pT4N0M1. After 3 cycles of MVAC therapy as adjuvant chemotherapy,new lymph node metastasis was revealed. He showed a complete response after 4 cycles of chemotherapy with gemcitabine and cisplatin (GC). He received 6 additional cycles of GC chemotherapy. Follow-up computed tomographic scan 3 months after the last chemotherapy showed portal vein thrombosis. He was treated with anticoagulant therapy,which dissolved the thrombus.
The Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
Norichika
N
Ueda
Masashi
M
Nakayama
Kyosuke
K
Matsuzaki
Yoshiyuki
Y
Yamamoto
Ken
K
Takeda
Wataru
W
Nakata
Yasuyuki
Y
Arai
Ken-ichi
K
Kakimoto
Kazuo
K
Nishimura
Mikio
M
Mukai
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D013927:Thrombosis / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000188:drug therapy*