Nanoparticles mimicking viral surface topography for enhanced cellular delivery.
Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20 μm).
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland, QLD, 4072, Australia.
Yuting
Y
Niu
Meihua
M
Yu
Sandy B
SB
Hartono
Jie
J
Yang
Hongyi
H
Xu
Hongwei
H
Zhang
Jun
J
Zhang
Jin
J
Zou
Annette
A
Dexter
Wenyi
W
Gu
Chengzhong
C
Yu
D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002232:Carbocyanines / Q000737:chemistry / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D011094:Polyethyleneimine / Q000737:chemistry; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D020691:rab GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D000097869:Polo-Like Kinase 1
D001672:Biocompatible Materials; D002232:Carbocyanines; D018797:Cell Cycle Proteins; D004337:Drug Carriers; D009841:Oligonucleotides; D011094:Polyethyleneimine; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D034741:RNA, Small Interfering; D012822:Silicon Dioxide; D020691:rab GTP-Binding Proteins; D000097869:Polo-Like Kinase 1; C105244:RAB33A protein, human; C089187:cyanine dye 3
biomimetic synthesis; drug delivery; nanoparticles; surface topography