Learning theories reveal loss of pancreatic electrical connectivity in diabetes as an adaptive response.
Cells of almost all solid tissues are connected with gap junctions which permit the direct transfer of ions and small molecules, integral to regulating coordinated function in the tissue. The pancreatic islets of Langerhans are responsible for secreting the hormone insulin in response to glucose stimulation. Gap junctions are the only electrical contacts between the beta-cells in the tissue of these excitable islets. It is generally believed that they are responsible for synchrony of the membrane voltage oscillations among beta-cells, and thereby pulsatility of insulin secretion. Most attempts to understand connectivity in islets are often interpreted, bottom-up, in terms of measurements of gap junctional conductance. This does not, however, explain systematic changes, such as a diminished junctional conductance in type 2 diabetes. We attempt to address this deficit via the model presented here, which is a learning theory of gap junctional adaptation derived with analogy to neural systems. Here, gap junctions are modelled as bonds in a beta-cell network, that are altered according to homeostatic rules of plasticity. Our analysis reveals that it is nearly impossible to view gap junctions as homogeneous across a tissue. A modified view that accommodates heterogeneity of junction strengths in the islet can explain why, for example, a loss of gap junction conductance in diabetes is necessary for an increase in plasma insulin levels following hyperglycemia.
Mathematics and Biology, Indian Insitute of Science Education and Research Pune, Pune, Maharashtra, India. pgoel@iiserpune.ac.in
Pranay
P
Goel
Anita
A
Mehta
D000222:Adaptation, Physiological; D017630:Connexins / Q000378:metabolism; D003920:Diabetes Mellitus / Q000473:pathology* / Q000503:physiopathology*; D055724:Electrophysiological Phenomena; D017629:Gap Junctions / Q000378:metabolism / Q000473:pathology; D006367:HeLa Cells; D006801:Humans; D050417:Insulin-Secreting Cells / Q000473:pathology* / Q000502:physiology*; D008954:Models, Biological; D000097004:Gap Junction delta-2 Protein
D017630:Connexins; D000097004:Gap Junction delta-2 Protein