The role of bacterial biofilms in device-associated infection.
There is increasing evidence that bacterial biofilm is responsible for the failure of medical devices, leading to device-associated infection. As plastic surgeons, we are among the leading users of prostheses in surgery, and it is important that we are kept informed of this growing problem. This article summarizes the pathogenesis of device-associated infection, outlines the evidence for such infection in a number of medical devices, and outlines operative strategies aimed at reducing the risk of bacterial contamination at the time of device deployment. It also outlines strategies under investigation to combat the development of device-associated infection.
Sydney, Australia; and Dallas, Texas From the From the Surgical Infection Research Group, Macquarie University; and the Department of Plastic Surgery, University of Texas Southwestern Medical Center.
Anand K
AK
Deva
William P
WP
Adams
Karen
K
Vickery
D018441:Biofilms; D006801:Humans; D019736:Prostheses and Implants / Q000382:microbiology; D011475:Prosthesis Failure / Q000209:etiology; D019919:Prosthesis Implantation / Q000009:adverse effects; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy*