[Identification of origins of marker chromosomes using fluorescence in situ hybridization].
OBJECTIVE
To assess the value of fluorescence in situ hybridization (FISH) and bacterial artificial chromosome FISH (BAC-FISH) for the diagnosis for patients with marker chromosomes.


METHODS
Sixteen patients with marker chromosomes were analyzed with technologies including GTG-banding, Q-banding, multiplex FISH and BAC-FISH.


RESULTS
The marker chromosomes in the 16 patients were verified as der(Y) (2 cases), psu dic(Y) (1 case), psu dic(15) (1 case), dic(15) (1 case), del(Y) (1 case), r(X) (5 cases), i(14 or 22) (2 cases), i(18) (1 case).


CONCLUSIONS
FISH and BAC-FISH can both verify the origin of marker chromosomes and provide accurate information for the diagnosis and treatment of patients.
Xiamen Prenatal Diagnosis Center, Xiamen Maternal & Child Health Care Hospital, Xiamen, Fujian 361003, P. R. China. zhou_yulin@126.com.
Qiong
Q
Wu
Yu-lin
YL
Zhou
Hui
H
Kong
Huan
H
Zeng
Hui-nan
HN
Wu
Yan-yan
YY
Sheng
Chao-yi
CY
Yang
Yun-sheng
YS
Ge
Mei-jiao
MJ
Cai
Ting-ting
TT
Huang
Jia-yan
JY
Chen
Xia-olu
XO
Chen
Dong-xing
DX
Zhou
Xin-gli
XG
Huang
D000293:Adolescent; D000328:Adult; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008297:Male; D055815:Young Adult
D005819:Genetic Markers