Thermodynamics-based mathematical model for solubility prediction of glibenclamide in ethanol-water mixtures.
Temperature-dependent solubility data of glibenclamide (GBN) in various ethanol-water mixtures is not reported in literature so far. Therefore, the aim of this study was to determine the mole fraction solubility of GBN in various ethanol-water mixtures at the temperature range of 293.15 to 318.15 K. The solubility of GBN was determined by reported shake flask method and the experimental data was fitted in thermodynamics-based modified Apelblat model. The solubility of GBN was found to be increased with increase in temperature and mass fraction of ethanol in ethanol-water mixtures. The experimental data of GBN was well correlated with the modified Apelblat model at each temperature range with correlation coefficient of 0.9940-1.0000. The relative absolute deviation (AD) was found to be less than 0.1% except in pure ethanol and water. The positive values of enthalpies and entropies for GBN dissolution indicated that its dissolution is endothermic and an entropy-driven process.
Center of Excellence in Biotechnology Research .
Faiyaz
F
Shakeel
Fars K
FK
Alanazi
Ibrahim A
IA
Alsarra
Nazrul
N
Haq
D000431:Ethanol / Q000737:chemistry*; D005905:Glyburide / Q000737:chemistry*; D008962:Models, Theoretical; D012995:Solubility; D013696:Temperature; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*
D014867:Water; D000431:Ethanol; D005905:Glyburide