Multiple-digit periungual Bowen's disease: a novel treatment approach with radiotherapy.
Multiple periungual Bowen disease [BD; also known as squamous cell carcinoma (SCC) in situ] is rare. The pathogenesis of the disease is linked to human papilloma virus, and in some instances to chronic immunosuppression. The usual management of periungual BD is by local excision, Mohs micrographic surgery or distal phalanx amputation. Our patient was offered radiotherapy in the hope of maximizing residual function and minimizing morbidity from treatment. A good response was seen at 2 months post-radiotherapy, but this was followed by relapses at 4 and 6 months post-radiotherapy. Persistent anonychia resulted in improved access to the involved skin, making topical therapy possible. Radiotherapy can be a valuable management approach for periungual SCC/BD in locations where amputation could result in substantial disability.
Peninsula College of Medicine and Dentistry, Royal Devon and Exeter Hospital, Exeter, UK and.
W T
WT
Hunt
A
A
Cameron
P
P
Craig
D A
DA
de Berker
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001913:Bowen's Disease / Q000188:drug therapy / Q000532:radiotherapy*; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D008297:Male; D009260:Nail Diseases / Q000188:drug therapy / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D016896:Treatment Outcome
D000970:Antineoplastic Agents