Group A streptococcal emm type prevalence among symptomatic children in Cape Town and potential vaccine coverage.
The molecular epidemiology of group A streptococcal pharyngeal infections in children in the Vanguard Community of Cape Town revealed 26 emm types among 157 isolates from 742 subjects. Coverage of a 30-valent vaccine is predicted to be 95% of pharyngitis cases in this population at high risk of rheumatic fever.
From the *Department of Medicine, Groote Schuur Hospital and University of Cape Town; †Department of Clinical Laboratory Sciences, Division of Microbiology, National Health Service and University of Cape Town, Cape Town, South Africa; and ‡University of Tennessee Health Science Center, Memphis, TN.
Mark E
ME
Engel
Babu
B
Muhamed
Andrew C
AC
Whitelaw
Munyaradzi
M
Musvosvi
Bongani M
BM
Mayosi
James B
JB
Dale
D000293:Adolescent; D000942:Antigens, Bacterial / Q000235:genetics* / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics* / Q000276:immunology; D002352:Carrier Proteins / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D017720:Molecular Epidemiology; D010612:Pharyngitis / Q000453:epidemiology / Q000382:microbiology; D015995:Prevalence; D012213:Rheumatic Fever; D013019:South Africa / Q000453:epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D022541:Streptococcal Vaccines / Q000008:administration & dosage*; D013297:Streptococcus pyogenes / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D022541:Streptococcal Vaccines; C014689:streptococcal M protein