Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.
The bi-functional complex [Pt(II)(terpy)(py-naphth)](NO3)2(), incorporating both 2,2':6',2''-terpyridine and 4-N,N'-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.
School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. jmkelly@tcd.ie gunnlaut@tcd.ie.
Swagata
S
Banerjee
Jonathan A
JA
Kitchen
Sandra A
SA
Bright
John E
JE
O'Brien
D Clive
DC
Williams
John M
JM
Kelly
Thorfinnur
T
Gunnlaugsson
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004273:DNA, Neoplasm / Q000737:chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D053644:Naphthalimides / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010984:Platinum / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013329:Structure-Activity Relationship
C517923:(2,2'-6',2'')-terpyridine; D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D053644:Naphthalimides; D009944:Organoplatinum Compounds; D011725:Pyridines; D010984:Platinum