High efficiency synthesis of F-18 fluoromethyl ethers: an attractive alternative for C-11 methyl groups in positron emission tomography radiopharmaceuticals.
A rapid and efficient method for the synthesis of O-fluoromethyl aliphatic and aromatic ethers is presented. This method is so mild that it can be used for the preparation of positron emission tomography (PET) radiopharmaceuticals bearing O-[(18)F]fluoromethyl groups.
Department of Chemistry, Sogang University, 35 Baekbeomro Mapogu, Seoul 121-742, Korea.
Chansoo
C
Park
Byoung Se
BS
Lee
Dae Yoon
DY
Chi
D002250:Carbon Radioisotopes / Q000737:chemistry*; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D014443:Tyrosine
D002250:Carbon Radioisotopes; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D019275:Radiopharmaceuticals; D014443:Tyrosine