Anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency.
Thalassemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are genetic disorders that cause hemolytic anemia. In areas with high frequencies of both hematological disorders, coinheritance of G-6-PD deficiency with thalassemia can be found. Whether G-6-PD deficiency, coinherited with thalassemia, enhances severe anemia is still unclear. Hematological parameters between thalassemia carriers with G-6-PD deficiency and those without G-6-PD deficiency were compared. The G-6-PD deficiency was diagnosed in 410 blood samples from thalassemia patients using a fluorescent spot test. The levels of hemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV) and Hb A2/Hb E [β26(B8)Glu→Lys; HBB: c.79G>A] were measured using an automated blood counter and high performance liquid chromatography (HPLC), respectively. The G-6-PD deficiency was found in 37 samples (9.02%). Mean levels of Hb, PCV, MCV and Hb A2/E were similar between the two groups. Thus, G-6-PD deficiency did not enhance red blood cell pathology or induce more anemic severity in thalassemia patients.
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang-Mai University , Chiang-Mai , Thailand.
Sakorn
S
Pornprasert
Siratcha
S
Phanthong
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000175:diagnosis / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000175:diagnosis / Q000235:genetics*; D006446:Hemoglobin E / Q000031:analogs & derivatives / Q000235:genetics; D006454:Hemoglobins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000150:complications* / Q000175:diagnosis / Q000235:genetics*; D055815:Young Adult; D017085:alpha-Thalassemia / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D017086:beta-Thalassemia / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D006442:Glycated Hemoglobin
D005954:Glucosephosphate Dehydrogenase; D006446:Hemoglobin E; D006454:Hemoglobins; C032271:glycated hemoglobin E; D006442:Glycated Hemoglobin