Changes in gastrosplenic circulation and splenic function after distal pancreatectomy with spleen preservation and splenic vessel excision.
BACKGROUND
Distal pancreatectomy with spleen preservation and splenic vessel excision is a commonly used technique. However, it produces significant gastrosplenic circulation and splenic function changes.


OBJECTIVE
The aim of this work was to determine the immediate consequences on gastrosplenic circulation, late consequences on splenic function, and development of varicose veins.


METHODS
Thirty-five patients with pancreatic tumors and anatomical feasibility were included. Preoperative splenic circulation was evaluated by dynamic contrast-enhanced computed tomography (CT) scans. Early splenic perfusion was assessed by CT 7 days after surgery and late changes in gastrosplenic circulation 6 months after surgery. Varicose veins were evaluated by CT and endoscopy 6 months after surgery. Pitted cells and Howell-Jolly bodies were used as markers of splenic function. Postoperatory findings included changes in splenic perfusion 7 days and 6 months after surgery, development of varicose veins on CT scans and endoscopy, and detection of markers of splenic hypofunction on blood smears.


CONCLUSIONS
Seven days after surgery, 63% of patients had some degree of splenic hypoperfusion, and 6 months after surgery, 83% of patients had normal perfusion. CT scans showed varices in 26 patients, and endoscopy revealed varicose veins in 11. Two patients experienced bleeding; markers of splenic hypofunction were found in 59% of cases.
Department of Surgery, Hospital Cosme Argerich, University of Buenos Aires, Buenos Aires, Argentina, gustavokohan@yahoo.com.ar.
Gustavo
G
Kohan
Carlos G
CG
Ocampo
Hugo I
HI
Zandalazini
Roberto
R
Klappenbach
Bernabe M
BM
Quesada
Luis T Chiappetta
LT
Porras
Juan Alvarez
JA
Rodriguez
Alejandro S
AS
Oria
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059351:Organ Sparing Treatments; D010180:Pancreatectomy / Q000009:adverse effects* / Q000379:methods; D011446:Prospective Studies; D012039:Regional Blood Flow; D013154:Spleen / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013270:Stomach / Q000098:blood supply*; D014057:Tomography, X-Ray Computed; D014648:Varicose Veins / Q000209:etiology; D055815:Young Adult