Cryptococcus neoformans meningoencephalitis in a patient with idiopathic CD4+ T lymphocytopenia.
Cryptococcus neoformans is a leading cause of invasive cryptoccocal infections which include meningitis/meningoencephalitis, cerebral cryptococcoma, invasive pulmonary and mediastinal infection. Invasive infection is mainly diagnosed in immunocompromised patients, especially in HIV-infected individuals. There is a rising number of patients with invasive cryptococcal infections in immunocompromised patients who are HIV-negative. Among several primary immunodeficiency syndromes, considered as possible reasons for these invasive infections, idiopathic CD4+ T lymphocytopenia (ICL) is most frequently diagnosed. The pathogenesis of this rare syndrome is still unknown, while its clinical spectrum ranges from an asymptomatic laboratory abnormality to life-threatening opportunistic infections. Here we present an HIV-negative young man suffering from cryptococcal meningoencephalitis in whom ICL was diagnosed.
University of Rijeka, Rijeka University Hospital Center, Clinic for Infectious Diseases, Rijeka, Croatia. ivica.pavic@medri.hr
Ivica
I
Pavić
Durdica
D
Cekinović
Josip
J
Begovac
Tomislav
T
Maretić
Rok
R
Civljak
Biserka
B
Troselj-Vukić
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology*; D003453:Cryptococcosis / Q000276:immunology*; D003455:Cryptococcus neoformans / Q000276:immunology* / Q000302:isolation & purification; D018023:HIV Seronegativity; D006801:Humans; D008231:Lymphopenia / Q000276:immunology / Q000382:microbiology*; D008297:Male; D008590:Meningoencephalitis / Q000276:immunology* / Q000382:microbiology*