Graphene-regulated cardiomyogenic differentiation process of mesenchymal stem cells by enhancing the expression of extracellular matrix proteins and cell signaling molecules.
The potential of graphene as a mesenchymal stem cell (MSC) culture substrate to promote cardiomyogenic differentiation is demonstrated. Graphene exhibits no sign of cytotoxicity for stem cell culture. MSCs are committed toward cardiomyogenic lineage by simply culturing them on graphene. This may be attributed, at least partially, to the regulation of expression levels of extracellular matrix and signaling molecules.
School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea.
Jooyeon
J
Park
Subeom
S
Park
Seungmi
S
Ryu
Suk Ho
SH
Bhang
Jangho
J
Kim
Jeong-Kee
JK
Yoon
Yoon Hwan
YH
Park
Sung-Pyo
SP
Cho
Seahyoung
S
Lee
Byung Hee
BH
Hong
Byung-Soo
BS
Kim
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D016326:Extracellular Matrix Proteins; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000166:cytology*; D015398:Signal Transduction
D016326:Extracellular Matrix Proteins; D006108:Graphite
cardiomyogenic; cell differentiation; extracellular matrix; graphene; mesenchymal stem cells