Hepatitis C virus-related lymphoproliferative disorders encompass a broader clinical and morphological spectrum than previously recognized: a clinicopathological study.
We describe a retrospective series of B-cell lymphoproliferative disorders associated with hepatitis C virus infection. In addition to splenic marginal zone lymphoma, follicular lymphoma and diffuse large B-cell lymphoma, all of which showed some specific features, we found two poorly described groups of cases. The first featured disseminated marginal zone lymphoma without splenic marginal zone lymphoma features, defying the current marginal zone lymphoma classification; the other consisted of monoclonal B lymphocytes in the peripheral blood, bone marrow or other tissues, with no clinical or histological evidence of lymphoma, and exhibiting a pattern that requires proper identification in order to avoid the misdiagnosis of the lymphoma. Diagnosis of hepatitis C virus infection-associated lymphoproliferative disorders requires the integration of clinical, pathological and molecular findings to establish an adequate diagnosis and decide the appropriate therapy to be applied.
Department of Pathology, Hospital Virgen de la Salud, Toledo, Spain.
Manuela
M
Mollejo
Department of Pathology, Hospital Gregorio Marañón, Madrid, Spain.
Javier
J
Menárguez
Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain.
Pablo
P
Guisado-Vasco
Department of Haematology, Hospital Gregorio Marañón, Madrid, Spain.
Leyre
L
Bento
Department of Genetics, Hospital Virgen de la Salud, Toledo, Spain.
Patrocinio
P
Algara
Department of Pathology, Hospital Universitario Marqués de Valdecilla-IFIMAV, Santander, Spain.
Santiago
0000000235658262
S
Montes-Moreno
Department of Pathology, Fundación Jiménez Díaz, Madrid, Spain.
María S
MS
Rodriguez-Pinilla
Department of Oncology, Hospital Virgen de la Salud, Toledo, Spain.
Miguel A
MA
Cruz
Department of Haematology, Hospital Virgen de la Salud, Toledo, Spain.
Felipe
F
Casado
Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain.
Carlos
C
Montalbán
Department of Pathology, Hospital Universitario Marqués de Valdecilla-IFIMAV, Santander, Spain.
Miguel A
MA
Piris
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000821:virology*; D008232:Lymphoproliferative Disorders / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies