Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.
Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
Southampton General Hospital, Southampton, Hampshire, United Kingdom. alastairmoss@gmail.com
Alastair J
AJ
Moss
Fiona P
FP
Gaughran
Aliyye
A
Karasu
Anthony S
AS
Gilbert
Alex J
AJ
Mann
Colin M
CM
Gelder
John S
JS
Oxford
Henry A
HA
Stephens
Rob
R
Lambkin-Williams
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000097:blood; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D059868:HLA-DP beta-Chains / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007110:Immunity, Active; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000097:blood / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D009975:Orthomyxoviridae / Q000276:immunology*; D014611:Vaccination; D022223:Vaccines, Subunit
D000914:Antibodies, Viral; D059868:HLA-DP beta-Chains; C505113:HLA-DPB1*04:01 antigen; D059811:HLA-DRB1 Chains; C553505:HLA-DRB1*04:01 antigen; D007252:Influenza Vaccines; D022223:Vaccines, Subunit