Resuscitation intensity at birth is associated with changes in brain metabolic development in preterm neonates.
BACKGROUND
Intensive resuscitation at birth has been linked to intraventricular haemorrhage (IVH) in the preterm neonate. However, the impact of less intensive resuscitation on more subtle alterations in brain metabolic development is largely unknown. Our objective was to determine the relationship between the intensity of neonatal resuscitation following preterm birth on brain metabolic development.


METHODS
One hundred thirty-three very preterm-born neonates (median gestational age [GA] 27 ± 2 weeks) underwent MR spectroscopic imaging early in life (median postmenstrual age 32 weeks) and again at term-equivalent age (median 40 weeks). Severity of white matter injury, IVH and cerebellar haemorrhage on magnetic resonance imaging were scored. Ratios of N-acetylaspartate (NAA) and lactate to choline (Cho) were calculated in eight regions of interest and were assessed in relation to intensiveness of resuscitation strategy (bag and mask, continuous positive airway pressure [CPAP], intubation, cardiopulmonary resuscitation [CPR]).


RESULTS
Within the first hour of life, 14 newborns had no intervention, 3 received bag and mask, 30 had CPAP, 79 were intubated and 7 had CPR. Resuscitated infants were more likely to have IVH (p = 0.02). More intensive resuscitation was associated with decreased NAA/Cho maturation (p < 0.001, adjusting for birth GA). Metabolic development was similar in neonates requiring CPAP in comparison to those receiving no intervention. The change in lactate/Cho did not differ across resuscitation categories (p = 0.8).


CONCLUSIONS
Intensity of resuscitation at birth is related to changes in metabolic brain development from early in life to term-equivalent age. Results suggest that preventing the need for intensive neonatal resuscitation may provide an opportunity to improve brain development in preterm neonates.
Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, ON, Canada.
Emma G
EG
Duerden
Meisan
M
Brown-Lum
Vann
V
Chau
Kenneth J
KJ
Poskitt
Ruth E
RE
Grunau
Anne
A
Synnes
Steven P
SP
Miller
D001928:Brain Diseases, Metabolic / Q000453:epidemiology* / Q000534:rehabilitation*; D001930:Brain Injuries / Q000453:epidemiology* / Q000534:rehabilitation*; D001955:British Columbia / Q000453:epidemiology; D015984:Causality; D015897:Comorbidity; D005260:Female; D006801:Humans; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000534:rehabilitation*; D008297:Male; D012151:Resuscitation / Q000706:statistics & numerical data*; D012307:Risk Factors; D016896:Treatment Outcome