Salivary mental stress proteins.
Of the major diagnostic specimen types, saliva is one of the most easily collected. Many studies have focused on the evaluation of salivary proteins secreted by healthy people and patients with various diseases during responses to acute mental stress. In particular, such studies have focused on cortisol, α-amylase, chromogranin A (CgA), and immunoglobulin A (IgA) as salivary stress markers. Each of these salivary stress markers has its own strengths and weaknesses as well as data gaps related to many factors including collection technique. In this review, we summarize the critical knowledge of the positive and negative attributes and data gaps pertaining to each salivary stress marker.
Diagnostic Unit for Amyloidosis, Department of Laboratory Medicine, Kumamoto University Hospital, 1-1-1 Honjo, Kumamoto 860-8556, Japan. Electronic address: konen@fc.kuh.kumamoto-u.ac.jp.
Konen
K
Obayashi
D015415:Biomarkers / Q000378:metabolism; D053379:Chromogranin A / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007070:Immunoglobulin A / Q000378:metabolism*; D055550:Protein Stability; D012463:Saliva / Q000737:chemistry; D012471:Salivary Proteins and Peptides / Q000378:metabolism*; D013048:Specimen Handling / Q000295:instrumentation / Q000592:standards; D013315:Stress, Psychological / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D014783:Viscosity; D000516:alpha-Amylases / Q000378:metabolism*
D015415:Biomarkers; D053379:Chromogranin A; D007070:Immunoglobulin A; D012471:Salivary Proteins and Peptides; D000516:alpha-Amylases; D006854:Hydrocortisone
ALS; CgA; IgA; Mental stress; Salivary chromogranin A (CgA); Salivary cortisol; Salivary immunoglobulin A (IgA); Salivary stress markers; Salivary α-amylase; amyotrophic lateral sclerosis; chromogranin A; immunoglobulin A