Tobacco smoke exposure during pregnancy increases maternal blood lead levels affecting neonate birth weight.
To assess the effect of lead exposure from cigarette smoke on fetal growth, blood lead concentrations were measured using inductively coupled plasma mass spectrometry in 150 healthy pregnant women. Mean lead concentrations in plasma and whole blood were significantly higher in the smoking group compared with the nonsmoking group in each trimester of pregnancy (p < 0.001). Logistic regression analysis showed the highest impact of the number of cigarettes smoked per day for serum lead concentration (β = 0.238; p < 0.05), while in whole blood, it was duration of smoking before conception (β = 0.297; p < 0.001). Birth weight of the smoking mothers' infants was significantly lower (mean ± SEM, 3,192 ± 50.8 and 3,569 ± 49.6 g, respectively; p < 0.001) and negatively correlated with lead levels in plasma (r = -0.38; p < 0.001) and in whole blood (r = -0.27; p < 0.001). Therefore, it is suggested that smoking during pregnancy increases lead concentrations in maternal blood. Fetal exposure to low doses of lead in utero may be a serious risk factor causing lower birth weight.
Screening Department, Institute of Mother and Child, Kasprzaka 17a, 01-211, Warsaw, Poland, magdalena.chelchowska@imid.med.pl.
Magdalena
M
Chelchowska
Jadwiga
J
Ambroszkiewicz
Katarzyna
K
Jablonka-Salach
Joanna
J
Gajewska
Tomasz M
TM
Maciejewski
Ewa
E
Bulska
Teresa
T
Laskowska-Klita
Jerzy
J
Leibschang
D016022:Case-Control Studies; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D052577:Infant, Extremely Low Birth Weight / Q000097:blood*; D007854:Lead / Q000097:blood*; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D012907:Smoking / Q000009:adverse effects* / Q000097:blood; D014028:Tobacco Smoke Pollution / Q000009:adverse effects* / Q000032:analysis
D014028:Tobacco Smoke Pollution; D007854:Lead