HSF1 in Translation.
The master regulator of the classical cytoprotective "heat shock" response, heat shock factor 1 (HSF1), is increasingly implicated in cancer pathogenesis, but the mechanisms remain poorly understood. A recent study connects increased protein translation to activation of HSF1 in malignant cells and demonstrates the therapeutic benefit of targeting this link.
Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.
Emmanuel
E
de Billy
Paul A
PA
Clarke
Paul
P
Workman
D000818:Animals; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D014176:Protein Biosynthesis / Q000502:physiology*; D012270:Ribosomes / Q000378:metabolism*; D014157:Transcription Factors / Q000096:biosynthesis*
D004268:DNA-Binding Proteins; D014157:Transcription Factors