Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains.
DT104 emerged as a new branch of Salmonella typhimurium with resistance to multiple antimicrobials. To reveal some general genomic features of DT104 for clues of evolutionary events possibly associated with the emergence of this relatively new type of this pathogen, we mapped 11 independent DT104 strains and compared them with non-DT104 S. typhimurium strains. We found that all 11 DT104 strains contained three insertions absent in non-DT104 strains, i.e., the previously reported ST104, ST104B and ST64B. However, SGI-1, a genomic island known to be responsible for DT104 multidrug resistance, was not present in all DT104 strains examined in this study: one DT104 strain did not contain SGI-1 but carried a 144 kb plasmid, suggesting possible evolutionary relationships between the two DNA elements in the development of antimicrobial resistance.
Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, 150081, Harbin, China.
Er-Ying
EY
Zhao
Hong-Xia
HX
Bao
Le
L
Tang
Qing-Hua
QH
Zou
Wei-Qiao
WQ
Liu
Da-Ling
DL
Zhu
Jessica
J
Chin
Ying-Ying
YY
Dong
Yong-Guo
YG
Li
Feng-Lin
FL
Cao
Cornelis
C
Poppe
Kenneth E
KE
Sanderson
Randal N
RN
Johnston
Daoguo
D
Zhou
Gui-Rong
GR
Liu
Shu-Lin
SL
Liu
D005075:Biological Evolution; D002874:Chromosome Mapping; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004706:Endodeoxyribonucleases; D015321:Gene Rearrangement; D016680:Genome, Bacterial / Q000235:genetics*; D044404:Genomic Islands / Q000502:physiology; D023281:Genomics; D010957:Plasmids / Q000235:genetics; D012480:Salmonella Infections / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000235:genetics*; D013045:Species Specificity
D004269:DNA, Bacterial; D004706:Endodeoxyribonucleases; C071132:endodeoxyribonuclease I-CeuI; C025580:endodeoxyribonuclease XBAI; C064053:CCTAGG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific