Inhibition of novel reassortant avian influenza H7N9 virus infection in vitro with three antiviral drugs, oseltamivir, peramivir and favipiravir.
BACKGROUND
A novel reassortant avian-origin influenza A (H7N9) virus was isolated from respiratory specimens obtained from three patients and was identified as H7N9 in China. Antiviral agents are required to treat patients with avian influenza H7N9 virus infection.


METHODS
In this study, we assessed the antiviral potential of oseltamivir, peramivir, favipiravir (T-705), amantadine and rimantadine against novel reassortant avian-origin influenza H7N9 virus in vitro.


RESULTS
All three avian influenza H7N9 virus strains were sensitive to oseltamivir, peramivir and favipiravir (T-705), but resistant to amantadine and rimantadine.


CONCLUSIONS
Our data show a pattern of antiviral sensitivity for this novel H7N9 strain of influenza that suggests the compounds oseltamivir, peramivir and favipiravir should be useful for therapy.
National Engineering Research Center for Strategic Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing, PR China.
Rui-Yuan
RY
Cao
Jun-Hai
JH
Xiao
Bin
B
Cao
Song
S
Li
Yohichi
Y
Kumaki
Wu
W
Zhong
D000146:Acids, Carbocyclic; D000577:Amides / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D003517:Cyclopentanes / Q000494:pharmacology; D004285:Dogs; D024882:Drug Resistance, Viral / Q000187:drug effects; D006146:Guanidines / Q000494:pharmacology; D064766:Influenza A Virus, H7N9 Subtype / Q000187:drug effects*; D061985:Madin Darby Canine Kidney Cells; D053139:Oseltamivir / Q000494:pharmacology; D011719:Pyrazines / Q000494:pharmacology; D016865:Reassortant Viruses / Q000187:drug effects*
D000146:Acids, Carbocyclic; D000577:Amides; D000998:Antiviral Agents; D003517:Cyclopentanes; D006146:Guanidines; D011719:Pyrazines; D053139:Oseltamivir; C462182:favipiravir; C414210:peramivir