Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides.
Red ginseng has a variety of bioactive functions and is widely used as an oriental medicinal herb and food ingredient. The aim of this study was to investigate the antiviral effect of red ginseng extract and ginsenosides against hepatitis A virus (HAV). To examine the antiviral effect against HAV, 0 to 10 μg/mL of red ginseng and purified ginsenoside Rb1 and Rg1 were pre-treated or co-treated on FRhK-4 cells. The HAV titer decreased significantly in all groups pretreated with red ginseng or purified ginsenosides. The reduction of HAV was significant in FRhK-4 cells pre-treated only with red ginseng. Our results showed that red ginseng and ginsenoside Rg1 and Rb1 could decrease HAV titers.
Dept. of Food and Nutrition, Chung-Ang Univ., Ansung, 456-756, Republic of Korea.
Min Hwa
MH
Lee
Bog-Hieu
BH
Lee
Sanghyun
S
Lee
Changsun
C
Choi
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D005506:Food Contamination / Q000517:prevention & control; D005516:Food Microbiology; D036145:Ginsenosides / Q000494:pharmacology*; D030041:Hepatitis A virus / Q000187:drug effects* / Q000254:growth & development; D008253:Macaca mulatta; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry
D000998:Antiviral Agents; D036145:Ginsenosides; D010936:Plant Extracts; C442759:ginsenoside Rb1; C035054:ginsenoside Rg1
antiviral; ginsenoside Rb1; ginsenoside Rg1; hepatitis A virus; red ginseng