Role of ciliary neurotrophic factor in the proliferation and differentiation of neural stem cells.
Ciliary neurotrophic factor (CNTF) is a pleiotropic cytokine that has been fully studied for its structure, receptor, and signaling pathways and its multiplex effects on neural system, skeletal muscle, and weight control. Recent research demonstrates that CNTF also plays an important role in neurogenesis and the differentiation of neural stem cells. In this article, we summarize the general characteristics of CNTF and its function on neural stem cells, which could be a valuable therapeutic strategy in treating neurological disorders.
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jun
J
Ding
Zhili
Z
He
Juan
J
Ruan
Zilong
Z
Ma
Ying
Y
Liu
Chengxin
C
Gong
Khalid
K
Iqbal
Shenggang
S
Sun
Honghui
H
Chen
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D020934:Ciliary Neurotrophic Factor / Q000502:physiology*; D006801:Humans; D058953:Neural Stem Cells / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*
D020934:Ciliary Neurotrophic Factor