Wild daffodils of the section Ganymedes from the Iberian Peninsula as a source of mesembrane alkaloids.
The aim of this work was to perform a detailed study of the alkaloid content of Narcissus triandrus, as well as a complete analysis of the alkaloid profile of 18 wild populations, comprising all the taxa of the section Ganymedes. Through the application of a combination of spectroscopic and chromatographic methods, the isolation and structural elucidation of 3 compounds are reported for the first time from a natural source (2-oxomesembrenone, 7,7a-dehydromesembrenone and 2-oxoepimesembranol), together with the identification of 5 major common mesembrane alkaloids. Additionally, the GC-MS analysis of the alkaloid profile demonstrated the regular presence of mesembranes in all the studied plants, showing mesembrenone as the predominant compound without any typical Amaryllidaceae alkaloid being detected.
Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona. Av. Diagonal 643, 08028 Barcelona, Spain.
Natalia B
NB
Pigni
Segundo
S
Ríos-Ruiz
F Javier
FJ
Luque
Francesc
F
Viladomat
Carles
C
Codina
Jaume
J
Bastida
D047151:Amaryllidaceae Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D005060:Europe; D008401:Gas Chromatography-Mass Spectrometry; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D031427:Narcissus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
C583555:3a-(3,4-dimethoxyphenyl)-1-methyloctahydro-1H-indol-6-ol; D047151:Amaryllidaceae Alkaloids; D026121:Indole Alkaloids; D010936:Plant Extracts
2-Oxoepimesembranol; 2-Oxomesembrenone; 7,7a-Dehydromesembrenone; Alkaloid profile; Amaryllidaceae; GC–MS; NMR; Narcissus triandrus; Section Ganymedes