Fabrication of multifunctional Gd2O3/Au hybrid nanoprobe via a one-step approach for near-infrared fluorescence and magnetic resonance multimodal imaging in vivo.
Facile fabrication of multimodal imaging probes is highly desired for bioimaging application due to their integrated advantages of several imaging modalities. Here, we report a simple and one-step mild strategy to fabricate a multifunctional Gd2O3/Au hybrid nanoprobe. Bovine serum albumin (BSA) was used as the template in the biomineralization synthesis. The fabricated BSA-Gd2O3/Au nanoprobe showed excellent chemical stability, intense near-infrared (NIR) fluorescence, and good magnetic resonance imaging (MRI) ability. The multimodal imaging potential of the prepared multifunctional nanoprobe was demonstrated by successful NIR fluorescent and magnetic resonance blood pool imaging. Further modification of BSA-Gd2O3/Au with arginine-glycine-aspartic acid peptide c(RGDyK) (RGD) enabled the nanoprobe for targeted tumor imaging in vivo.
State Key Laboratory of Medicinal Chemical Biology (Nankai University), Synergetic Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Shao-Kai
SK
Sun
Lu-Xi
LX
Dong
Yang
Y
Cao
Hao-Ran
HR
Sun
Xiu-Ping
XP
Yan
D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D005682:Gadolinium / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D064847:Multimodal Imaging / Q000379:methods*; D017433:Protein Structure, Secondary; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D023041:Xenograft Model Antitumor Assays / Q000379:methods
C030581:gadolinium oxide; D006046:Gold; D005682:Gadolinium