Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome.
Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.
VTT Technical Research Centre of Finland, Espoo, Finland.
Riitta
R
Puupponen-Pimiä
Tuulikki
T
Seppänen-Laakso
Matti
M
Kankainen
Johanna
J
Maukonen
Riitta
R
Törrönen
Marjukka
M
Kolehmainen
Tiina
T
Leppänen
Eeva
E
Moilanen
Liisa
L
Nohynek
Anna-Marja
AM
Aura
Kaisa
K
Poutanen
Francisco A
FA
Tómas-Barberán
Juan C
JC
Espín
Kirsi-Marja
KM
Oksman-Caldentey
D001794:Blood Pressure / Q000187:drug effects; D003374:Coumarins / Q000652:urine; D005638:Fruit / Q000737:chemistry*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000382:microbiology*; D006801:Humans; D047348:Hydrolyzable Tannins / Q000494:pharmacology* / Q000652:urine; D008055:Lipids / Q000097:blood*; D024821:Metabolic Syndrome / Q000178:diet therapy* / Q000378:metabolism* / Q000382:microbiology; D064307:Microbiota; D016896:Treatment Outcome
D003374:Coumarins; D047348:Hydrolyzable Tannins; D008055:Lipids; C013515:ellagitannin; C588364:urolithin C; C026423:3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
Clinical trial; Ellagitannin-rich berries; Lipidomics; Microbiological profiling; Urolithins