Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions.
BACKGROUND
In almost every chronic wound different bacteria species can be detected.


METHODS
Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany.


RESULTS
Data of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6% of these were methicillin-resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south-north gradient for S. aureus, P. aeruginosa, and enterobacteria. Moreover, a highly significant west-east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis, respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates.


CONCLUSIONS
Our data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany.
Department of Dermatology, Venereology and Allergology, University Clinic of Essen, Germany.
Finja
F
Jockenhöfer
Harald
H
Gollnick
Katharina
K
Herberger
Georg
G
Isbary
Regina
R
Renner
Markus
M
Stücker
Eva
E
Valesky
Uwe
U
Wollina
Michael
M
Weichenthal
Sigrid
S
Karrer
Joachim
J
Klode
Joachim
J
Dissemond
D000368:Aged; D001419:Bacteria / Q000302:isolation & purification*; D002908:Chronic Disease; D002980:Climate; D005260:Female; D005858:Germany / Q000453:epidemiology; D019538:Health Care Surveys; D006801:Humans; D007871:Leg Ulcer / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D014871:Water Microbiology; D014945:Wound Healing