Basaloid squamous cell carcinoma of the oral cavity: an analysis of 92 cases.
OBJECTIVE
Basaloid squamous cell carcinoma (BSCC) is considered a rare and possibly more aggressive squamous cell carcinoma (SCC) variant. Until now, a series of exclusively oral cavity BSCC patients has not been previously reported. We endeavored to compare BSCC and SCC of the oral cavity, focusing on epidemiologic factors and survival outcomes.


METHODS
Retrospective analysis of population-based data.


METHODS
We compared epidemiologic factors, clinicopathologic data, and disease-specific survivals (DSS) between 92 patients with oral cavity BSCC and 15,181 patients with SCC.


RESULTS
High-grade tumors and distant metastases were more common in the BSCC group (P≤0.001). On multivariable analysis controlling for disease stage, BSCC patients had similar DSS to those with typical SCC (P=0.231). Although there was a trend favoring definitive radiotherapy for BSCC, there were no significant differences in treatment approach between BSCC and SCC. The choice of treatment modality (radiation, surgery±radiation) did not reveal a difference in DSS between the two tumor subtypes.


CONCLUSIONS
Analysis of the largest oral cavity BSCC series to date demonstrates that BSCC of the oral cavity carries a comparable prognosis to conventional-type oral SCC.


METHODS
2b.
Department of Otolaryngology Head and Neck Surgery (V.A.F., E.J.L.), Medical University of South Carolina, Charleston, South Carolina.
Valerie A
VA
Fritsch
Daniel R
DR
Gerry
Eric J
EJ
Lentsch
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002281:Carcinoma, Basosquamous / Q000175:diagnosis / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000628:therapy*; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D016634:Radiosurgery / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000970:Antineoplastic Agents
Basaloid squamous cell carcinoma; SEER database; oral cavity; squamous cell carcinoma