Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.
The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of α-synuclein in the development of a subset of dopaminergic neurons.
Centre for Brain Repair, Dept. of Clinical Neurosciences, Cambridge, UK.
Pablo
P
Garcia-Reitboeck
Oleg
O
Anichtchik
Jeffrey W
JW
Dalley
Natalia
N
Ninkina
George K
GK
Tofaris
Vladimir L
VL
Buchman
Maria Grazia
MG
Spillantini
D000818:Animals; D002452:Cell Count; D059290:Dopaminergic Neurons / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013378:Substantia Nigra / Q000166:cytology* / Q000378:metabolism; D051844:alpha-Synuclein / Q000235:genetics / Q000378:metabolism*
D051844:alpha-Synuclein
Dopaminergic; Embryonic development; Parkinson's disease; Transgenic mouse; α-Synuclein