Characterization of micellar systems produced by new amphiphilic conjugates of poly(ethylene glycol).
This study proposes polymeric micelles produced using new amphiphilic conjugates between amino- or carboxy-mPEG2000 and three different α-lipoamino acids (PEG-LAA). The characterization of these colloidal systems showed CMC values, in the order of 10(-5 )M, that are interesting in the view of an in vivo administration. The PEG-LAA micelles also showed a good stability at 37 °C and upon dilution in aqueous media. Using a colored probe as a model lipophilic compound, the loading efficiency and in vitro release profile were also outlined.
Sezione di Tecnologia Farmaceutica, Dipartimento di Scienze del Farmaco, Università degli Studi di Catania - Viale A. Doria , Catania , Italy .
R
R
Pignatello
V
V
Pantò
L
L
Basile
A
A
Leonardi
C
C
Guarino
C
C
La Rosa
D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004355:Drug Stability; D008823:Micelles; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*
D004337:Drug Carriers; D008823:Micelles; D011092:Polyethylene Glycols
CMC; conductimetry; lipoamino acids; micelles