[Comparative study on mathematical set-based drug release kinetics method and Kalman filter method applied in evaluating drug release of multi-component traditional Chinese medicine preparations].
OBJECTIVE
To provide a mathematical set-based method for evaluating drug release kinetics of multi-component traditional Chinese medicine preparations.


METHODS
With Fuzheng Huayu prescription as the study model, a mathematical set-based method for evaluating drug release kinetics was established to guide the preparation of drug release system of Fuzheng Huayu prescription, and a quantitative evaluation was made for its multi-component drug release characteristics. Its accuracy was verified by Kalman filtering method.


RESULTS
The comparison between the two showed that the sample No. 4 of Fuzheng Huayu drug release system showed synchronized drug release with its reference preparation Fuzheng Huayu capsules.


CONCLUSIONS
The results verified the accuracy and rationality of the evaluation method based on mathematics set. Meanwhile, it displayed the release of target preparations according to asynchronous coefficient (k) and other parameters, and found the orientation of regulating and improving the unit drug release dosage from relevant error parameters of various characteristic peak information, in order to purposefully regulate relevant components, and enable target preparations to meet the synchronized drug release requirements of the reference preparation. Meanwhile, it provided an effective measure for evaluating the quantitative characterization and synchronized release behavior of multi-component traditional Chinese medicines.
Shanghai School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. alansusu@sina.com
Lan
L
Shen
Yu
Y
Zhai
Shi-Yu
SY
Ma
Xiao
X
Lin
Yi
Y
Feng
Ke-Feng
KF
Ruan
D002214:Capsules; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D005374:Filtration; D006801:Humans; D007700:Kinetics; D008516:Medicine, Chinese Traditional; D008962:Models, Theoretical
D002214:Capsules; D004365:Drugs, Chinese Herbal