Antitumor activity of new enantiopure pybox-ruthenium complexes.
New ruthenium complexes containing enantiopure 2,6-bis[4'(R)-phenyloxazolin-2'-il-pyridine] ((R,R)-Ph-pybox), 2,6-bis[4'(S)-isopropyloxazolin-2'-il-pyridine] ((S,S)-(i)Pr-pybox) or 2,6-bis[4'(R)-isopropyloxazolin-2'-il-pyridine] ((R,R)-(i)Pr-pybox) and water soluble 1,3,5-triaza-7-phosphaadamantane (PTA) or N-substituted PTA phosphanes have been synthesized in high yields and fully characterized. The interactions of these compounds with plasmidic DNA and their cytotoxic activity against the human cervical cancer HeLa cell line are reported, pointing out for the first time the different behaviour of ruthenium enantiomers affecting the cell cycle in HeLa tumor cells.
Departamento de Química Orgánica e Inorgánica, Instituto de Química Organometálica "Enrique Moles" (Unidad Asociada al C.S.I.C.). Universidad de Oviedo, 33006 Oviedo, Principado de Asturias, Spain. elb@uniovi.es.
Estefania
E
Menéndez-Pedregal
Josefina
J
Díez
Ángel
Á
Manteca
Jesús
J
Sánchez
Ana C
AC
Bento
Rósula
R
García-Navas
Faustino
F
Mollinedo
M Pilar
MP
Gamasa
Elena
E
Lastra
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D004247:DNA / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D010080:Oxazoles; D011725:Pyridines; D012428:Ruthenium; D004247:DNA