Brain activity for visual judgment of lifted weight.
It is well established that humans can recognize high-level aspects from point-light biological motion, such as gender and mood. If the task is to judge the manipulated weight we expected that sensorimotor regions should be recruited in the brain. Moreover, we have recently shown that chronic pain in a limb that is involved in the presented movement disturbs the weight judgment. We therefore hypothesized that some cortical regions usually activated during the processing of pain will also be activated while viewing point-light biological motion with the instruction to judge the manipulated weights. We investigated point-light biological motion of two types of movements performed with different weights in a blocked fMRI experiment in healthy subjects. In line with our a priori hypothesis, we found strong activity in the regions known as the neuromatrix of pain, such as the anterior cingulate (ACC), insula, as well as primary and secondary somatosensory regions. We also found activation in the occipital and temporal regions that are typical for biological motion, as well as regions in the cerebellum and prefrontal cortex. The activation of the somatosensory regions probably serves the judgment of the biological motion stimuli. Activation of the anterior cingulate and the insula might be explained by their role in the integration of behaviorally relevant information. Alternatively, these structures are known to be involved in the processing of nociceptive information and pain. So it seems possible that the interference between judgment of weights and perception of pain in chronic pain patients occurs in the somatosensory areas, anterior cingulate and/or insula. This finding provides important information as to the underlying mechanisms used for the weight judgment task, but also why chronic pain interferes with this task.
Department of Biological and Clinical Psychology, Friedrich Schiller University Jena, Jena, Germany; Department of Sports Medicine and Health Promotion, Friedrich Schiller University Jena, Jena, Germany.
Alexander
A
Ritter
Thomas
T
Weiss
Marcel
M
Franz
Marc H E
MH
de Lussanet
D000328:Adult; D001416:Back Pain / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002531:Cerebellum / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D059350:Chronic Pain / Q000503:physiopathology; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D007600:Judgment; D008279:Magnetic Resonance Imaging; D008297:Male; D004856:Postural Balance / Q000502:physiology; D017397:Prefrontal Cortex / Q000503:physiopathology; D013003:Somatosensory Cortex / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*; D014891:Weight Lifting / Q000502:physiology*; D055815:Young Adult
2330; Action perception; Back pain; Manipulation of weights; Point-light biological motion; Sensory integration; fMRI