Basal cell carcinoma of the prostate: clinicopathologic analysis of three cases and a review of the literature.
BACKGROUND
Although conventional adenocarcinoma accounts for the majority of prostatic carcinomas, it is important to recognize rare variants, like basal cell carcinoma (BCC), which has distinctive histopathological and biological features.


METHODS
We analyzed three cases of prostatic BCC and all of them complained of acute urinary retention and digital rectal examination disclosed a stony hard prostate. However, all of them presented with low prostate-specific antigen. The diagnosis relied on transrectal ultrasound-guided needle biopsies or transurethral resection of the prostate (TURP). The microscopic findings suggested basaloid cells with large pleomorphic nuclei and scant cytoplasm, showing peripheral palisading and forming solid nests, and immunohistochemical markers like 34βE12, p63 and Ki67 staining, were positive. After active treatment, two of the patients are alive with tumor and one died five months after discharge from our hospital.
Department of Urology, Fudan University Shanghai Cancer Center, 136 Yi Xue Yuan Road, Shanghai 200032, China.
Kun
K
Chang
Bo
B
Dai
YunYi
Y
Kong
YuanYuan
Y
Qu
JianNong
J
Wu
DingWei
D
Ye
XuDong
X
Yao
ShiLin
S
Zhang
HaiLiang
H
Zhang
Yao
Y
Zhu
WeiQiang
W
Yao
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000150:complications / Q000556:secondary* / Q000628:therapy; D002280:Basal Cell Carcinoma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000150:complications / Q000556:secondary* / Q000628:therapy; D008175:Lung Neoplasms / Q000150:complications / Q000556:secondary* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D012189:Retrospective Studies; D012196:Review Literature as Topic; D020728:Transurethral Resection of Prostate
D014408:Biomarkers, Tumor