Spiking the MERS-coronavirus receptor.
A novel coronavirus, the Middle East respiratory syndrome coronavirus, recently emerged through zoonotic transmission, causing a severe lower respiratory tract infection in humans. In two recent papers, one published in Cell Research, the crystal structure of the viral receptor-binding domain in complex with the host CD26/dipeptidyl peptidase 4 receptor has now been characterized.
Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands.
Berend Jan
BJ
Bosch
V Stalin
VS
Raj
Bart L
BL
Haagmans
D000818:Animals; D017934:Coronavirus / Q000737:chemistry* / Q000378:metabolism*; D018819:Dipeptidyl Peptidase 4 / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D011991:Receptors, Virus / Q000737:chemistry* / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*; D053585:Virus Attachment
D011991:Receptors, Virus; D014764:Viral Proteins; D018819:Dipeptidyl Peptidase 4