Quantum dot approaches for target-based drug screening and multiplexed active biosensing.
Biomolecule detection using quantum dots (Qdots), nanometer-sized semiconductor crystals, effectively addresses the limitations associated with conventional optical and biochemical techniques, as Qdots offer several key advantages over traditional fluorophores. In this minireview, we discuss the role of Qdots as a central nanoscaffold for the polyvalent assembly of multifunctional biomolecular probes and describe recent advances in Qdot-based biorecognition. Specifically, we focus on Qdot applications in target-based, drug screening assays and real-time active biosensing of cellular processes.
Departments of Chemistry, Vanderbilt University, Nashville, TN, USA.
Oleg
O
Kovtun
Xochitl
X
Arzeta-Ferrer
Sandra J
SJ
Rosenthal
D000818:Animals; D001667:Binding, Competitive; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation / Q000379:methods*; D023381:Endpoint Determination / Q000295:instrumentation / Q000379:methods; D006801:Humans; D058990:Molecular Targeted Therapy; D045663:Quantum Dots / Q000737:chemistry*; D013499:Surface Properties