The kinase-independent, second life of CDK6 in transcription.
CDK6 is an oncogenic kinase regulating the cell cycle. In this issue of Cancer Cell, Kollmann and colleagues demonstrate that CDK6 performs a kinase-independent transcriptional function in regulating expression of VEGF-A and p16INK4a. These observations link the cell cycle machinery and angiogenesis and reveal the presence of a fail-safe antiproliferative mechanism.
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Tobias
T
Otto
Piotr
P
Sicinski
D000818:Animals; D051361:Cyclin-Dependent Kinase 6 / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000201:enzymology*
D051361:Cyclin-Dependent Kinase 6