[Nocturnal dipping of heart rate in patients with proliferative diabetic retinopathy and iris and/or angle neovascularization].
OBJECTIVE
To evaluate the relationship between nocturnal dipping in heart rates and iris and/or angle neovascularization (NV) in patients with proliferative diabetic retinopathy(PDR).


METHODS
One hundred fifty-one patients with PDR who underwent surgery were divided into groups based on either the presence or absence of iris and/or angle NV (NV group, 37; non-NV group, 114 patients). Pulse oximetry was conducted overnight and the heart rates were measured both before and during sleep; the resting and nocturnal heart rates and the resting-nocturnal heart rate dip ratio were calculated.


RESULTS
The resting and nocturnal heart rates did not differ significantly between the two groups. The resting-nocturnal heart rate dip ratio was significantly lower in the NV group than in the non-NV group (p = 0.006). In the NV group, the frequency of insulin therapy (p = 0.003) and a history of coronary artery disease were significantly (p = 0.033) higher than in the non-NV group. Pearson's correlation analysis showed that only the NV group was significantly negatively correlated with the resting-nocturnal heart rate dip ratio (r = -0.18, t value = -2.2, p = 0.028).


CONCLUSIONS
In patients with PDR, the non-occurrent of nocturnal dip in heart rate may be a related factor for iris and/or angle neovascularization.
Department of Ophthalmology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura-shi, Chiba-ken 285-8741, Japan. chieko.shiba@med.toho-u.ac.jp
Chieko
C
Shiba
Mao
M
Takahashi
Izumi
I
Yoshida
Makoto
M
Ubuka
Jyunya
J
Ashizawa
Tomoaki
T
Shiba
Yuichi
Y
Hori
Yukihiro
Y
Sato
Takatoshi
T
Maeno
D000368:Aged; D000369:Aged, 80 and over; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007498:Iris / Q000098:blood supply* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D012146:Rest / Q000502:physiology; D012890:Sleep / Q000502:physiology