Is depression simply a nonspecific response to brain injury?
Depressive disorders are among the most common ailments affecting humankind and some of the world's leading causes of medical disability. Despite being common, disabling and a major public health problem, the etiology of depression is unknown. Indeed, investigators have suggested that the causes of depression are multiple and multi-factorial. With these considerations in mind, in this article we examine the hypothesis that our inability to identify the causes of depressive disorders is because depression is a nonspecific epiphenomenon of brain injury or insult arising through multiple pathways.
Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Stephen.Strakowski@uc.edu
Stephen M
SM
Strakowski
Caleb M
CM
Adler
Melissa P
MP
Delbello
D000928:Antidepressive Agents / Q000627:therapeutic use; D001930:Brain Injuries / Q000523:psychology*; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D012307:Risk Factors
D000928:Antidepressive Agents