In vitro effects of L-carnitine on coronary artery bypass grafts.
BACKGROUND
The gold standard treatment for multivessel coronary revascularization is coronary artery bypass grafting. The internal mammary artery and saphenous vein grafts are the conduits most frequently used for these operations. Spasm of arterial and venous grafts is a significant problem during the operation.


OBJECTIVE
To evaluate the acute in vitro effects of L-carnitine on internal mammary artery and saphenous vein grafts using a tissue bath.


METHODS
Ten consecutive patients who underwent elective coronary artery bypass grafting were enrolled in the present study (nine men, one woman; mean [± SD] age 62±9.1 years). Samples from left internal mammary artery and saphenous vein grafts were collected from each patient. Submaximal smooth muscle contraction was achieved by adding 1 μM phenylephrine, and L-carnitine was then added to the solution. The concentration-response curves of the vasodilation response were obtained.


RESULTS
In the internal mammary graft samples, the vasodilation response to L-carnitine was 64.3±11.1% at a concentration of 5 mM. In the saphenous vein graft samples, the vasodilation response to L-carnitine was 41.5±11.4% at a concentration of 5 mM. There was a statistically significant difference (P<0.001) between the response of the internal mammary artery and saphenous vein grafts in the in vitro tissue bath system.


CONCLUSIONS
These results indicate that L-carnitine is a potential vasodilatory drug for internal mammary artery and saphenous vein grafts.
Cardiovascular Surgery Department, Trakya University Hospital, Edirne, Turkey.
Orkut
O
Güçlü
Volkan
V
Yüksel
Serhat
S
Hüseyin
Turan
T
Ege
Suat
S
Canbaz
Mutasim
M
Süngün
Coronary artery bypass; Internal mammary artery; L-carnitine; Saphenous vein