Use of sulfated cyclofructan 6 and sulfated cyclodextrins for the chiral separation of four basic pharmaceuticals by capillary electrophoresis.
Sulfated cyclofructan 6 (S-CF6) and sulfated cyclodextrins (S-α-, β-, γ-CDs) are highly selective chiral selectors for the enantioseparation of basic solutes. In this study, S-CF6 was introduced for the enantiomeric separation of four basic pharmaceuticals (including tamsulosin, tiropramide, bupivacaine, and norephedrine) by capillary electrophoresis (CE), and the enantiomeric separation performance was compared with S-α-, β-, γ-CDs. The effects of the chiral selector type, chiral selector concentration, operating voltage, and column temperature were examined and optimized. Excellent resolutions were obtained for all solutes on these chiral selectors.
College of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, P. R. China; Department of Chemistry, Graduate School, Kyungpook National University, Daegu, Korea.
Yi Jun
YJ
Zhang
Ming Xian
MX
Huang
Yu Ping
YP
Zhang
Daniel Wayne
DW
Armstrong
Zachary S
ZS
Breitbach
Jae Jeong
JJ
Ryoo
D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D005630:Fructans / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000302:isolation & purification*; D013237:Stereoisomerism; D013431:Sulfates / Q000737:chemistry*; D013696:Temperature
D003505:Cyclodextrins; D005630:Fructans; D004364:Pharmaceutical Preparations; D013431:Sulfates; C557358:cyclofructan 6
basic pharmaceuticals; capillary electrophoresis; chiral separations; sulfated cyclodextrins; sulfated cyclofructan 6