Ketotifen-induced nocturnal bruxism.
Nocturnal bruxism is a common oromandibular movement disorder highly prevalent in children, but its pathophysiological mechanism has not been fully explained. Iatrogenic sleep bruxism has been described following treatment with several psychotropic medications. However, no case of antihistamine-induced bruxism has been reported to date. Herein, we describe a 4-year-old child who experienced nocturnal bruxism during treatment for bronchospasm and rhinitis with the antihistamine ketotifen. Drug rechallenge was also performed.


CONCLUSIONS
The present case adds useful information to our knowledge of bruxism. Complex and poorly understood interactions between multiple central nervous system neurotransmitters, such as histamine, serotonin, and dopamine, are involved.
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy, domenicoitaliano@hotmail.com.
Domenico
D
Italiano
Placido
P
Bramanti
David
D
Militi
Stefania
S
Mondello
Rocco Salvatore
RS
Calabro
D002675:Child, Preschool; D006634:Histamine H1 Antagonists / Q000009:adverse effects*; D006801:Humans; D007665:Ketotifen / Q000009:adverse effects*; D008297:Male; D020186:Sleep Bruxism / Q000139:chemically induced* / Q000175:diagnosis
D006634:Histamine H1 Antagonists; D007665:Ketotifen