Quality of life in pediatric patients with unremitting constipation pre and post Malone Antegrade Continence Enema (MACE) procedure.
OBJECTIVE
The primary aim of this study was to determine if there is a change in the quality of life in pediatric patients with unremitting functional constipation and/or encopresis after undergoing a MACE procedure.


METHODS
Patients, ages 5 to 18 years with unremitting constipation and a normal evaluation, including anorectal manometry and colonic manometry, who opted to undergo a MACE procedure were contacted to participate in the study. Patients with congenital anorectal malformations as well as spinal cord disorders were excluded from the study. The patient's parent/guardian completed the PedsQL(TM) Generic Core Scales QOL survey prior to the operation, 6 months, and 12 months after the procedure.


RESULTS
A total of 15 consecutive patients meeting protocol criteria were recruited within a period of 20 months. The mean age at the MACE procedure was 9.8 years (range 7.0-11.1). 5 patients were female. The mean QOL score pre-MACE was 64.1. At 6 months post-MACE the mean overall QOL score was 90.2, and it was 92.0 at 12 months. All 15 patients at the 6 month follow up had significant improvement in their QOL (p=1.9 × 10(-7)) and all subcategories of QOL were significantly improved as well.


CONCLUSIONS
A MACE procedure is of benefit to otherwise normal pediatric patients who have unremitting functional constipation with failure of medical treatment. Our patients had a significant improvement in all QOL categories and overall QOL.
Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.
Aileen F
AF
Har
Frederick J
FJ
Rescorla
Joseph M
JM
Croffie
D000293:Adolescent; D001676:Biofeedback, Psychology; D002431:Cecostomy / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003248:Constipation / Q000523:psychology* / Q000601:surgery / Q000628:therapy; D004688:Encopresis / Q000523:psychology / Q000601:surgery / Q000628:therapy; D004733:Enema / Q000379:methods*; D005244:Fecal Impaction / Q000517:prevention & control; D005242:Fecal Incontinence / Q000523:psychology / Q000601:surgery / Q000628:therapy; D005260:Female; D006801:Humans; D054368:Laxatives / Q000627:therapeutic use; D008297:Male; D011183:Postoperative Complications / Q000209:etiology / Q000523:psychology; D011788:Quality of Life; D054047:Surgical Stomas
D054368:Laxatives
Functional constipation; Malone antegrade continence enema; Quality of life