Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst.
This paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd-Cu/C catalyst through a cascade Sonogashira alkynylation-cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows the preparation of heterocycles with good yields and is tolerant to a wide variety of functional groups.
Université de Bordeaux, UMR CNRS 5255, ISM, 351 cours de la Libération, 33405 Talence Cedex, France ; Université de Nantes, UFR Sciences et Techniques, UMR CNRS 6230, CEISAM, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Cybille
C
Rossy
Eric
E
Fouquet
François-Xavier
FX
Felpin
benzofuran; bimetallic catalyst; heterogeneous catalysis; indole; water