TRPA1 and other TRP channels in migraine.
Ever since their identification, interest in the role of transient receptor potential (TRP) channels in health and disease has steadily increased. Robust evidence has underlined the role of TRP channels expressed in a subset of primary sensory neurons of the trigeminal ganglion to promote, by neuronal excitation, nociceptive responses, allodynia and hyperalgesia. In particular, the TRP vanilloid 1 (TRPV1) and the TRP ankyrin 1 (TRPA1) are expressed in nociceptive neurons, which also express the sensory neuropeptides, tachykinins, and calcitonin gene-related peptide (CGRP), which mediate neurogenic inflammatory responses. Of interest, CGRP released from the trigeminovascular network of neurons is currently recognized as a main contributing mechanism of migraine attack. The ability of TRPA1 to sense and to be activated by an unprecedented series of exogenous and endogenous reactive molecules has now been extensively documented. Several of the TRPA1 activators are also known as triggers of migraine attack. Thus, TRP channels, and particularly TRPA1, may be proposed as novel pathways in migraine pathophysiology and as possible new targets for its treatment.
Headache Center and Clinical Pharmacology Unit, Department of Health Sciences, Careggi University Hospital, University of Florence, viale Pieraccini 6, Florence 50139, Italy. silvia.benemei@unifi.it.
Silvia
S
Benemei
Francesco
F
De Cesaris
Camilla
C
Fusi
Eleonora
E
Rossi
Chiara
C
Lupi
Pierangelo
P
Geppetti
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D006801:Humans; D008881:Migraine Disorders / Q000378:metabolism* / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009437:Neuralgia / Q000378:metabolism / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism; D000074025:TRPA1 Cation Channel; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050051:Transient Receptor Potential Channels