The effects in correction of anaemia in chronic kidney disease with erythropoietin therapy--preference to cardiovascular, neurologic and general well-being of patients from a tertiary care centre.
Anaemia, the major sequelae of chronic renal disease (CRD) needs to be investigated because it acts as an independent risk factor for worsening of cardiovascular survival, cognitive impairment and poor quality of life. In this prospective tertiary care hospital-based study we have followed up 100 randomly assigned CRD patients who were not on dialysis for at least 6 months. Left ventricular mass index (LVMI), ejection fraction (EF), mini-mental status examination (MMSE) and general well-being of these patients were assessed quantitatively on admission and at 3rd and 6th months of follow-up after receiving recombinant human erythropoietin (rHuEPO) and aggressive intravenous iron therapy for anaemia correction. The median study duration was 6 years. Statistical analysis also showed the positive impact of anaemia correction which, even when partial, caused significant improvement in cardiovascular function as evidenced by increase in EF (p = 0.004) and decrease in LVMI (p = 0.016) along with substantial enhancement of general well-being (p < 0.001). Cognition did not show significant change within a short spell of 6 months. This study thus emphasises on earliest detection and correction of anaemia in CRD population to enhance both short-term and long-term survival as a whole.
Department of Medicine, NRS Medical College and Hospital, Kolkata 700014.
Prasanta
P
Mukhopadhyay
Uma
U
Sinha
Jasamalya
J
Banerjee
Atanu Roy
AR
Choudhury
Cyriac Abby
CA
Philips
D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006304:Health Status; D006352:Heart Ventricles / Q000473:pathology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008603:Mental Health; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology; D013318:Stroke Volume
D006454:Hemoglobins; D004921:Erythropoietin