Determination of enantioselectivity and enantiomeric excess by mass spectrometry in the absence of chiral chromatographic separation: an overview.
This review describes the principles and instrumentation for the screening of asymmetric reactions by mass spectrometry. These techniques witnessed a significant advancement in the last few years. Although some of them are still at the proof-of-concept development stage, several applications might be foreseen in the field of combinatorial, high-throughput parallel catalyst screening.
Department of Chemistry, University of Roma Sapienza, P.le Aldo Moro 5, 00185 Roma, Italy.
Susy
S
Piovesana
Roberto
R
Samperi
Aldo
A
Laganà
Marco
M
Bella
analytical chemistry; enantiomeric excess; enantioselectivity; mass spectrometry