nCal: an R package for non-linear calibration.
CONCLUSIONS
Non-linear calibration is a widely used method for quantifying biomarkers wherein concentration-response curves estimated using samples of known concentrations are used to predict the biomarker concentrations in the samples of interest. The R package nCal fills an important gap in the open source, stand-alone software for performing non-linear calibration. For curve fitting, nCal provides a new implementation of a robust, Bayesian hierarchical five-parameter logistic model. nCal supports a simple graphical user interface that can be used by laboratory scientists, and contains functionality for importing data from the multiplex bead array assay instrumentation.


BACKGROUND
The R package 'nCal' is available from http://cran.r-project.org/web/packages/nCal/ under GPL-2 or later.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Youyi
Y
Fong
Krisztian
K
Sebestyen
Xuesong
X
Yu
Peter
P
Gilbert
Steve
S
Self
D001499:Bayes Theorem; D002138:Calibration; D017711:Nonlinear Dynamics; D011381:Programming Languages; D012984:Software