Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature.
The effects of salt concentration and temperature on the thermodynamics of DNA minor groove binding have quite different signatures: binding enthalpy is salt concentration independent but temperature dependent. Conversely, binding free energy is salt dependent but essentially temperature independent through enthalpy-entropy compensation.
Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. wdw@gsu.edu.
Shuo
S
Wang
Arvind
A
Kumar
Karl
K
Aston
Binh
B
Nguyen
James K
JK
Bashkin
David W
DW
Boykin
W David
WD
Wilson
D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D015394:Molecular Structure; D012492:Salts / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry*; D013816:Thermodynamics
D012492:Salts; D012965:Sodium Chloride; D004247:DNA