Human dental pulp stem cell behavior using natural nanotolith/bacterial cellulose scaffolds for regenerative medicine.
Adhesion and Viability study with human dental pulp stem cell using natural nanotolith/bacterial cellulose scaffolds for regenerative medicine are presented at first time in this work. Nanotolith, are osteoinductors, i.e., they stimulate bone regeneration, enabling higher cells migration for bone tissue regeneration formation. This is mainly because nanotoliths are rich minerals present in the internal ear of bony fish. In addition, are part of a system which acts as a depth sensor and balance, acting as a sound vibrations detector and considered essential for the bone mineralization process, as in hydroxiapatites. Nanotoliths influence in bacterial cellulose was analyzed using transmission infrared spectroscopy (FTIR). Results shows that fermentation process and nanotoliths agglomeration decrease initial human dental pulp stem cell adhesion however tested bionanocomposite behavior has cell viability increase over time.
Department of Nanoscience and Advanced Materials-UFABC, Rua Santa Adélia, 16, 09210-170, Santo André-SP, Brazil. gabriel.ufabc@gmail.com
Gabriel Molina
GM
Olyveira
Gerson Arisoly Xavier
GA
Acasigua
Ligia Maria Manzine
LM
Costa
Cristiane Regina
CR
Scher
Lauro
L
Xavier Filho
Patricia Helena Lucas
PH
Pranke
Pierre
P
Basmaji
D053687:Adult Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002482:Cellulose / Q000737:chemistry / Q000494:pharmacology*; D003782:Dental Pulp / Q000166:cytology*; D048388:Gadiformes; D006801:Humans; D008903:Minerals / Q000737:chemistry / Q000494:pharmacology*; D053758:Nanoparticles / Q000737:chemistry; D010037:Otolithic Membrane / Q000737:chemistry*; D012038:Regeneration / Q000187:drug effects / Q000502:physiology; D044968:Regenerative Medicine / Q000295:instrumentation*; D054457:Tissue Scaffolds / Q000737:chemistry
D008903:Minerals; D002482:Cellulose