Effect of armodafinil on cognition in patients with HIV/AIDS and fatigue.
Fatigue and cognitive impairment are common in HIV+ adults and may occur independently or be causally linked. This study examined whether alleviation of fatigue with armodafinil in a placebo-controlled double-blind 4-week trial had an effect on cognitive function among those with and without mild neuropsychological impairment at baseline. Sixty-one patients completed a standard battery of neuropsychological tests at study entry and Week 4: A total of 33 were randomized to armodafinil and 28 to placebo. While there was a significant effect of active medication on fatigue, cognitive performance measured by a global change score did not differ between treatment groups, or in those on active treatment with or without mild neuropsychological impairment.
a Department of Psychiatry , College of Physicians and Surgeons, Columbia University , New York , NY , USA.
Martin
M
McElhiney
Judith
J
Rabkin
Wilfred
W
Van Gorp
Richard
R
Rabkin
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000523:psychology*; D000328:Adult; D000368:Aged; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology*; D003627:Data Interpretation, Statistical; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004311:Double-Blind Method; D004651:Employment; D005221:Fatigue / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications / Q000523:psychology*; D006526:Hepatitis C / Q000150:complications / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077408:Modafinil; D009483:Neuropsychological Tests; D012367:RNA, Viral / Q000097:blood; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders / Q000150:complications / Q000523:psychology; D016896:Treatment Outcome; D014705:Verbal Behavior; D019562:Viral Load; D055815:Young Adult
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D012367:RNA, Viral; D000077408:Modafinil