Preformed albumin corona, a protective coating for nanoparticles based drug delivery system.
The non-specific interaction between nanoparticles (NPs) and plasma proteins occurs immediately after NPs enter the blood, resulting in the formation of the protein corona that thereafter replaces the original NPs and becomes what the organs and cells really see. Consequently, the in vivo fate of NPs and the biological responses to the NPs are changed. This is one substantial reason for the two main problems of the NPs based drug delivery system, i.e. nanotoxicity and rapid clearance of NPs from the blood after intravenous injection. Here, we demonstrate the successful application of the preformed albumin corona in inhibiting the plasma proteins adsorption and decreasing the complement activation, and ultimately in prolonging the blood circulation time and reducing the toxicity of the polymeric PHBHHx NPs. Since the interaction of proteins with various nano-materials and/or -particles is ubiquitous, pre-forming albumin corona has a great potential to be a versatile strategy for optimizing the NPs based drug delivery system.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Qiang
Q
Peng
Shu
S
Zhang
Qin
Q
Yang
Ting
T
Zhang
Xue-Qin
XQ
Wei
Li
L
Jiang
Chao-Liang
CL
Zhang
Qian-Ming
QM
Chen
Zhi-Rong
ZR
Zhang
Yun-Feng
YF
Lin
D000418:Albumins / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems / Q000379:methods*; D056945:Hep G2 Cells; D006801:Humans; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry*; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000418:Albumins
Albumin; Long circulation; Nanoparticles; Opsonization; Protein adsorption; Toxicity