Risk factors for depression in the elderly inflammatory bowel disease population.
OBJECTIVE
Little is known about depression in elderly individuals with inflammatory bowel diseases (IBD). We assessed the point prevalence of depression and determined associations with disease activity, quality of life, and medication adherence in elderly patients with IBD.


METHODS
We identified elderly (≥ 65 years) individuals within Crohn's and Colitis Foundation of America Partners, an online IBD cohort. Individuals completed the short geriatric depression scale (GDS). We used bivariate statistics to determine whether demographic or disease-related factors, disease activity, quality of life or medication adherence was associated with depression. We used logistic regression to estimate independent effects of depression on medication adherence.


RESULTS
A total of 359 elderly individuals with IBD completed the GDS. The mean age was 70.2 years (SD 4.7); mean disease duration was 25.6 years (SD 17.6), and 62.6% had Crohn's disease (CD). The point prevalence of depression was 22.6%. Lower education levels (p=0.001), higher corticosteroid use (<0.01) and lower exercise levels (<0.001) were associated with depression. For both CD and ulcerative colitis (UC), those with depression had increased disease activity (short Crohn's disease activity index 52.5 versus 29, p=0.005, and simple clinical colitis activity index 5 versus 2, p=0.003). Depressed patients had lower quality of life (short IBD questionnaire 4.6 versus 5.7, p<0.001). Depressed individuals had reduced medication adherence (adjusted OR 2.18; 95% CI 1.04-4.57).


CONCLUSIONS
Depression is common in this geriatric IBD cohort. Depression is independently associated with reduced medication adherence. Recognition and treatment of depression in elderly patients with IBD could improve outcomes.
University of North Carolina at Chapel Hill, Department of Medicine, Division of Gastroenterology and Hepatology, USA; Center for Gastrointestinal Biology and Disease, Chapel Hill, NC, USA. Electronic address: millie_long@med.unc.edu.
Millie D
MD
Long
Center for Gastrointestinal Biology and Disease, Chapel Hill, NC, USA; University of North Carolina at Chapel Hill, Department of Pediatrics, Division of Gastroenterology and Hepatology, USA.
Michael D
MD
Kappelman
University of North Carolina at Chapel Hill, Department of Medicine, Division of Gastroenterology and Hepatology, USA; Center for Gastrointestinal Biology and Disease, Chapel Hill, NC, USA.
Christopher F
CF
Martin
Center for Gastrointestinal Biology and Disease, Chapel Hill, NC, USA.
Wenli
W
Chen
Center for Gastrointestinal Biology and Disease, Chapel Hill, NC, USA; Geisel School of Medicine at Dartmouth, USA.
Kristen
K
Anton
University of North Carolina at Chapel Hill, Department of Medicine, Division of Gastroenterology and Hepatology, USA; Center for Gastrointestinal Biology and Disease, Chapel Hill, NC, USA.
Robert S
RS
Sandler
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000523:psychology*; D003424:Crohn Disease / Q000188:drug therapy / Q000523:psychology*; D003863:Depression / Q000453:epidemiology / Q000523:psychology*; D004522:Educational Status; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D009043:Motor Activity; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life / Q000523:psychology; D012307:Risk Factors; D012720:Severity of Illness Index
D000305:Adrenal Cortex Hormones
Adherence; Crohn's disease; Depression; Inflammatory bowel disease; Ulcerative colitis