Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections.
We have synthesized newer series of quinolone derivatives substituted with hydrazine group (6a-e) and sulfonamide group (7a-e). These compounds were screened for antibacterial activity. All these compounds were fully characterized by spectroscopic means and elemental analysis. From minimum inhibitory concentration (MIC) data, it has been observed that all the synthesized compounds exhibited good antibacterial activity in vitro.
Department of Applied Chemistry, Faculty of Engineering and Technology, M.J.P. Rohilkhand University, Bareilly 243006, U.P., India. Electronic address: drnimjpru@rediffmail.com.
Nivedita
N
Srivastava
Anil
A
Kumar
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001424:Bacterial Infections / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012485:Salmonella typhi / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
C587516:1-ethyl-3-carbohydrazide; C587517:3-(1-oxo-2-hydrazino-3-(p-toluenesulfon))quinolone; D000900:Anti-Bacterial Agents; D006834:Hydrazines; D015363:Quinolones
Antibacterial; Broad spectrum; Fluoroquinolone; Hydrazine; Quinolone; Sulfonamide