Improved synthesis of N1-substituted orotic acid derivatives.
An improved method for the synthesis of N1-substituted orotic acid derivatives is reported. The method involves sequential incorporation of nitrogen atoms to the pyrimidine structure from simple starting materials and thus allows the synthesis of N1-substituted orotic acid derivatives with single15N label at either N-1 or N-3.
Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 USA.
Nicholas A
NA
Senger
Jeannette T
JT
Bowler
Rene S
RS
Mercado
Sidney
S
Lin
Weiming
W
Wu
1-substituted orotic acid; 1-substituted uracil; 5-bromouracil; Orotic acid; dihydrouracil; orotidine