IL-11: a prominent pro-tumorigenic member of the IL-6 family.
Cytokines have recently emerged as important players in tumor promotion and progression. In this issue of Cancer Cell, Putoczki and colleagues report the importance of interleukin 11 in a variety of gastrointestinal malignances and lay down a framework for its potential inhibition in a variety of human cancers.
Cancer Prevention and Control Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-2497, USA. sergey.grivennikov@fccc.edu
Sergei I
SI
Grivennikov
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D005770:Gastrointestinal Neoplasms / Q000276:immunology*; D006801:Humans; D017370:Interleukin-11 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*
D017370:Interleukin-11; D015850:Interleukin-6