Efficient formation of luminescent lanthanide(III) complexes by solid-phase synthesis and on-resin screening.
Time-resolved luminescence measurements of luminescent lanthanide complexes have advantages in biological assays and high-throughput screening, owing to their high sensitivity. In spite of the recent advances in their energy-transfer mechanism and molecular-orbital-based computational molecular design, it is still difficult to estimate the quantum yields of new luminescent lanthanide complexes. Herein, solid-phase libraries of luminescent lanthanide complexes were prepared through amide-condensation and Pd-catalyzed coupling reactions and their luminescent properties were screened with a microplate reader. Good correlation was observed between the time-resolved luminescence intensities of the solid-phase libraries and those of the corresponding complexes that were synthesized by using liquid-phase chemistry. This method enabled the rapid and efficient development of new sensitizers for Sm(III), Eu(III), and Tb(III) luminescence. Thus, solid-phase combinatorial synthesis combined with on-resin screening led to the discovery of a wide variety of luminescent sensitizers.
Graduated School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 (Japan), Fax: (+81) 6-6879-7875.
Tatsuya
T
Nakamura
Shin
S
Mizukami
Miho
M
Tanaka
Kazuya
K
Kikuchi
D002384:Catalysis; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008024:Ligands; D010165:Palladium / Q000737:chemistry; D011789:Quantum Theory; D060327:Solid-Phase Synthesis Techniques; D013050:Spectrometry, Fluorescence; D014466:Ultraviolet Rays
D056831:Coordination Complexes; D028581:Lanthanoid Series Elements; D008024:Ligands; D010165:Palladium
lanthanides; ligand effects; luminescence; sensitizers; solid-phase synthesis