Intracortical multiplication of thalamocortical signals in mouse auditory cortex.
Cortical processing of sensory information begins with the transformation of thalamically relayed signals. We optogenetically silenced intracortical circuits to isolate thalamic inputs to layer 4 neurons and found that intracortical excitation linearly amplified thalamocortical responses underlying frequency and direction selectivity, with spectral range and tuning preserved, and prolonged the response duration. This signal pre-amplification and prolongation enhanced the salience of thalamocortically relayed information and ensured its robust, faithful and more persistent representation.
Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Ling-yun
LY
Li
Ya-tang
YT
Li
Mu
M
Zhou
Huizhong W
HW
Tao
Li I
LI
Zhang
D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D001303:Auditory Cortex / Q000166:cytology* / Q000502:physiology*; D000075402:Channelrhodopsins; D000229:Dependovirus / Q000235:genetics; D005260:Female; D049452:Green Fluorescent Proteins / Q000235:genetics; D051379:Mice; D062308:Optogenetics; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism; D018408:Patch-Clamp Techniques; D010775:Photic Stimulation; D011930:Reaction Time; D011984:Sensory Receptor Cells / Q000502:physiology*; D018709:Statistics, Nonparametric; D014161:Transduction, Genetic
D000075402:Channelrhodopsins; D010320:Parvalbumins; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins