[Advance in studies on anti-tumor activity of polysaccharides in latest five years].
Polysaccharides widely exist in animals, plants, microorganisms, and possess various biological activities including anti-tumor, anti-virus, anti-oxidant and immunomodulatory. Polysaccharides shows notable anti-tumor activity and less toxicity, and becomes a hotspot in the studies of anti-tumor drugs. Therefore, there is huge potential for developing polysaccharides into a novel antitumor medicine. This article summarized polysaccharides derived from animals, plants, microorganisms which have significant antitumor effect in the latest 5 years; findings indicate that polysaccharides show the anti-tumor effect directly by inducing tumor cell apoptosis and indirectly as an immunoenhancement. This article also looks into the future of studies on anti-tumor activity of polysaccharides.
Department of Pharmacology, Wannan Medical College, Wuhu 241000, China.
Jun
J
Lin
Ping
P
Li
Kao-Shan
KS
Chen
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*; D011134:Polysaccharides / Q000494:pharmacology* / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects
D000970:Antineoplastic Agents; D007155:Immunologic Factors; D011134:Polysaccharides