Rosavirus: the prototype of a proposed new genus of the Picornaviridae family.
We describe a 8,724-nucleotide-long picornavirus genome encoding a single 2,470-aa polyprotein obtained from the feces of a wild mouse. Rosavirus is genetically closest to the double ORF Dicipivirus found in canine feces that is currently the only picornavirus with a second internal ribosome entry site (IRES). Of note, a section of rosavirus' 5'UTR showed strong sequence and structural conservation with the type II IRES from the Parechovirus and Hungarovirus genera possibly reflecting exchange of genetic modules between genera. Based on genetic distance criteria rosavirus qualifies as prototype of a new genus of the Picornaviridae family.
Blood Systems Research Institute, San Francisco, CA, 94118, USA.
Tung Gia
TG
Phan
Nguyen Phung
NP
Vo
Peter
P
Simmonds
Erik
E
Samayoa
Samia
S
Naccache
Charles Y
CY
Chiu
Eric
E
Delwart
D020121:5' Untranslated Regions; D000818:Animals; D001483:Base Sequence; D004285:Dogs; D005243:Feces / Q000821:virology; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D010849:Picornaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010850:Picornaviridae Infections / Q000662:veterinary* / Q000821:virology; D012376:Rodent Diseases / Q000821:virology*
D020121:5' Untranslated Regions