Annette Bunge: developing the principles in percutaneous absorption using chemical engineering principles.
Annette Bunge and her research group have had the central theme of mathematically modeling the dermal absorption process. Most of the research focus has been on estimating dermal absorption for the purpose of risk assessment, for exposure scenarios in the environment and in the occupational setting. Her work is the basis for the United States Environmental Protection Agency's estimations for dermal absorption from contaminated water. It is also the basis of the dermal absorption estimates used in determining if chemicals should be assigned a 'skin notation' for potential systemic toxicity following occupational skin exposure. The work is truly translational in that it started with mathematical theory, is validated with preclinical and human experiments, and then is used in guidelines to protect human health. Her valued research has also extended into the topical drug bioavailability and bioequivalence assessment field.
University of Maryland School of Pharmacy, Baltimore, MD 21201, USA. astinchc@rx.umaryland.edu
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D000818:Animals; D002616:Chemical Engineering / Q000266:history / Q000379:methods*; D004781:Environmental Exposure / Q000009:adverse effects; D017408:Guidelines as Topic; D049673:History, 20th Century; D006801:Humans; D008962:Models, Theoretical; D016273:Occupational Exposure / Q000009:adverse effects; D018570:Risk Assessment; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D014481:United States; D014484:United States Environmental Protection Agency; D014874:Water Pollutants, Chemical / Q000633:toxicity
D014874:Water Pollutants, Chemical