Rocuronium reversed by sugammadex versus mivacurium during high-risk eye surgery: an institutional anaesthetic practice evaluation.
OBJECTIVE
This institutional anaesthetic practice evaluation compared patient safety with respect to residual neuromuscular blockade (NMB) at the time of tracheal extubation in patients undergoing high-risk eye surgery.


METHODS
Two muscle relaxation regimens were compared: rocuronium administered via intravenous (i.v.) bolus dosing combined with reversal through sugammadex at end of surgery (group R/S; 17 patients); mivacurium administered via continuous i.v. infusion without antagonization (group M; 22 patients). Train-of-four (TOF) monitoring determined the depth of NMB.


RESULTS
The TOF ratio at the time of tracheal extubation was greater in group R/S (median 1.03) than in group M (median 0.62). Time from end of surgery to tracheal extubation was not significantly different. The surgeons were 100% satisfied with the working conditions provided under both relaxation regimens.


CONCLUSIONS
Residual postoperative curarization at the time of extubation was frequently observed in group M, whereas there was complete recovery in group R/S. Reversal of NMB by sugammadex provides an additional safety dimension to patient care and should thus be considered especially for those at risk of airway complications or aspiration, in addition to frail patients.
Department of Anesthesiology and Intensive Care Medicine CCM / CVK, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Susanne
S
von Quillfeldt
Bettina
B
Föhre
Nicolai
N
Andrees
Claudia D
CD
Spies
Daniele
D
Galvagni
Antonia M
AM
Joussen
Klaus D
KD
Wernecke
Willehad
W
Boemke
D000328:Adult; D000368:Aged; D060666:Airway Extubation; D000732:Androstanols; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D000777:Anesthetics; D005260:Female; D006801:Humans; D007546:Isoquinolines; D008297:Male; D008875:Middle Aged; D000077590:Mivacurium; D019148:Neuromuscular Blockade / Q000379:methods; D003473:Neuromuscular Nondepolarizing Agents; D013508:Ophthalmologic Surgical Procedures; D000077123:Rocuronium; D000077122:Sugammadex; D011795:Surveys and Questionnaires; D013997:Time Factors; D047408:gamma-Cyclodextrins / Q000627:therapeutic use*
D000732:Androstanols; D000777:Anesthetics; D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077590:Mivacurium; D000077123:Rocuronium
Anaesthesia; curarization; general; ophthalmology; patient safety; reversal