An insight into genetics of non-syndromic cleft palate.
Our proband is a 29-year-old man, who is affected with soft cleft palate and hypernasality. A study of about six generations of this family pedigree shows that cleft palate has repeatedly occurred in males, with probably a X-linked recessive pattern of inheritance. Interestingly, the sister of the proband is affected with hypernasality and she has an affected son. This is the first report of X-linked inheritance pattern of cleft palate in Iran.
Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran ; Pediatric Inherited Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Nayereh
N
Nouri
Padideh
P
Karimi
Salehi
S
Mansoor
Mehrdad
M
Memarzadeh
Hamid
H
Ganji
Maryam
M
Sedghi
Cleft palate; X-linked; inheritance pattern