Dual effects of molybdenum on mouse oocyte quality and ovarian oxidative stress.
A sub-acute toxicity test was performed to investigate the effects of molybdenum (Mo) on ovarian function. ICR adult female mice were exposed to Mo by free access to distilled water containing the Mo at 5, 10, 20, and 40 mg/L for 14 days. Compared to the control group, M II oocyte morphology, ovary index, and ovulation improved within the 5 mg/L Mo group, but were negatively affected by Mo at 40 mg/L. Morphologically abnormal ovarian mitochondria were observed at ≥ 20 mg/L. These alterations accompanied the changes in superoxide dismutase (SOD), glutathione peroxidise (GPx), and malondialdehyde (MDA) levels in ovaries. In conclusion, Mo affects oocyte quality possibly through regulating ovarian oxidative stress in a dose-dependent manner. It appears that Mo may improve ovarian function at a suitable concentration, which might be a candidate for the treatment of female infertility.
College of Animal Science and Technology , Henan University of Science and Technology , Luoyang , PR China.
Yu-Ling
YL
Zhang
Feng-Jun
FJ
Liu
Xiao-Li
XL
Chen
Zi-Qiang
ZQ
Zhang
Run-Zhe
RZ
Shu
Xue-Li
XL
Yu
Xiao-Wei
XW
Zhai
Li-Jun
LJ
Jin
Xue-Gang
XG
Ma
Qiao
Q
Qi
Zhi-Jie
ZJ
Liu
D000818:Animals; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D046529:Microscopy, Electron, Transmission; D008982:Molybdenum / Q000494:pharmacology*; D009865:Oocytes / Q000187:drug effects* / Q000648:ultrastructure; D010053:Ovary / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism
D008315:Malondialdehyde; D008982:Molybdenum; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase