Antiviral functions of CD8(+) cytotoxic T cells in teleost fish.
Cytotoxic T-cells (CTLs) play a pivotal role in eliminating viruses in mammalian adaptive immune system. Many recent studies on T-cell immunity of fish have suggested that teleost CTLs are also important for antiviral immunity. Cellular functional studies using clonal ginbuan crucian carp and rainbow trout have provided in vivo and in vitro evidence that in many respects, virus-specific CTLs of fish have functions similar to those of mammalian CTLs. In addition, mRNA expression profiles of CTL-related molecules, such as CD8, TCR and MHC class I, have shown that in a wide range of fish species, CTLs are involved in antiviral adaptive immunity. These findings are a basis to formulate possible vaccination strategies to trigger effective antiviral CTL responses in teleost fish. This review describes recent advances in our understanding of antiviral CTL functions in teleost fish and discusses vaccination strategies for efficiently inducing CTL activities.
Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan. Electronic address: somamoto@agr.kyushu-u.ac.jp.
Tomonori
T
Somamoto
Section of Anatomy and Pathology, Institute of Basic Science and Aquatic Medicine, Norwegian School of Veterinary Science, Ullevålsveien 72, 0033 Oslo, Norway.
Erling Olaf
EO
Koppang
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Infectology, 17493 Greifswald-Insel Riems, Germany.
Uwe
U
Fischer
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005393:Fish Diseases / Q000276:immunology*; D005399:Fishes / Q000276:immunology*; D014765:Viral Vaccines; D014777:Virus Diseases / Q000276:immunology*
D014765:Viral Vaccines
Cytotoxic T cells; Teleost; Vaccination; Virus