Anti-glycine receptor antibody mediated progressive encephalomyelitis with rigidity and myoclonus associated with breast cancer.
We describe a 66-year-old woman who presented with a dramatic course of PERM. Anti-glycine receptor antibodies were found. She stabilized after plasma-exchange and partly recovered. Eighteen months later, a diagnosis of smouldering breast cancer with bone marrow metastasis was made. There are indications that this tumor was already present at first presentation. An overview of PERM and anti-glycine receptor antibodies is given.
Department of Neurology, AZ Sint Jan Brugge Oostende, 8000 Brugge, Belgium.
Sofie N
SN
De Blauwe
Patrick
P
Santens
Ludo J
LJ
Vanopdenbosch