Introductory Chemistry: A Molar Relaxivity Experiment in the High School Classroom.
Dotarem and Magnevist, two clinically available magnetic resonance imaging (MRI) contrast agents, were assessed in a high school science classroom with respect to which is the better contrast agent. Magnevist, the more efficacious contrast agent, has negative side effects because its gadolinium center can escape from its ligand. However, Dotarem, though a less efficacious contrast agent, is a safer drug choice. After the experiment, students are confronted with the FDA warning on Magnevist, which enabled a discussion of drug efficacy versus safety. We describe a laboratory experiment in which NMR spin lattice relaxation rate measurements are used to quantify the relaxivities of the active ingredients of Dotarem and Magnevist. The spin lattice relaxation rate gives the average amount of time it takes the excited nucleus to relax back to the original state. Students learn by constructing molar relaxivity curves based on inversion recovery data sets that Magnevist is more relaxive than Dotarem. This experiment is suitable for any analytical chemistry laboratory with access to NMR.
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, United States.
Anna C
AC
Dawsey
Kathryn L
KL
Hathaway
Susie
S
Kim
Travis J
TJ
Williams
Analytical Chemistry; Applications of Chemistry; Drugs/Pharmaceutical; First-Year Undergraduate/General; Hands-On Learning/Manipulative; High School/Introductory Chemistry; Laboratory Instruction; NMR Spectroscopy; Second-Year Undergraduate