Protein complexes: breaking up is hard to do well.
Mass spectrometry of protein assemblies reveals size and stoichiometry. In this issue of Structure, Hall and colleagues demonstrate that gas-phase dissociations can recapitulate solution structure for complexes with few intersubunit salt bridges, high charge density, inflexible subunits, or small intersubunit interfaces.
Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rachel R Ogorzalek
RR
Loo
Joseph A
JA
Loo
D000818:Animals; D006801:Humans; D056004:Molecular Dynamics Simulation; D011228:Prealbumin / Q000737:chemistry*; D021122:Protein Subunits / Q000737:chemistry*; D000683:Serum Amyloid P-Component / Q000737:chemistry*
D011228:Prealbumin; D021122:Protein Subunits; D000683:Serum Amyloid P-Component