[Study on preparation of testosterone undecanoate ethosomes and its in vitro transdermal penetration].
Ethosomes, as a new vector for transdermal drug delivery, could obviously improve the transdermal penetration of drugs. In this study, we prepared testosterone undecanoate ethosomes, with TU ethosomes as the basic remedy, to determine its appearance, particle size, entrapment efficiency (EE) and membrane fluidity. Meanwhile, a transdermal test was conducted in mice, in order to determine the permeability characteristics of ethosomes as a vector for transdermal drug delivery, and compare transdermal behaviors of TU ethosomes, liposomes and their ethanol solutions.
Liaoning Institute of Family Planning, Shenyang 110031, China.
Shu
S
Meng
Li-Qun
LQ
Yang
Li-Ying
LY
Ma
Jing
J
Guo
Miao
M
Li
Dan
D
Yang
D000279:Administration, Cutaneous; D000818:Animals; D016503:Drug Delivery Systems; D008081:Liposomes / Q000737:chemistry; D051379:Mice; D012869:Skin Absorption; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry
D008081:Liposomes; D013739:Testosterone; C010792:testosterone undecanoate