Systems biology of host-mycobiota interactions: dissecting Dectin-1 and Dectin-2 signalling in immune cells with DC-ATLAS.
Modelling the networks sustaining the fruitful coexistence between fungi and their mammalian hosts is becoming increasingly important to control emerging fungal pathogens. The C-type lectins Dectin-1 and Dectin-2 are involved in host defense mechanisms against fungal infection driving inflammatory and adaptive immune responses and complement in containing fungal burdens. Recognizing carbohydrate structures in pathogens, their engagement induces maturation of dendritic cells (DCs) into potent immuno-stimulatory cells endowed with the capacity to efficiently prime T cells. Owing to these properties, Dectin-1 and Dectin-2 agonists are currently under investigation as promising adjuvants in vaccination procedures for the treatment of fungal infection. Thus, a detailed understanding of events' cascade specifically triggered in DCs upon engagement is of great interest in translational research. Here, we summarize the current knowledge on Dectin-1 and Dectin-2 signalling in DCs highlighting similarities and differences. Detailed maps are annotated, using the Biological Connection Markup Language (BCML) data model, and stored in DC-ATLAS, a versatile resource for the interpretation of high-throughput data generated perturbing the signalling network of DCs.
Fondazione Edmund Mach, Research and Innovation Centre, San Michele all'Adige (TN), Italy.
Lisa
L
Rizzetto
Carlotta
C
De Filippo
Damariz
D
Rivero
Samantha
S
Riccadonna
Luca
L
Beltrame
Duccio
D
Cavalieri
D016208:Databases, Factual; D003713:Dendritic Cells / Q000276:immunology*; D005658:Fungi / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D037181:Lectins, C-Type / Q000276:immunology / Q000378:metabolism*; D009181:Mycoses / Q000276:immunology*; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D049490:Systems Biology; D051996:Transcription Factor RelA / Q000378:metabolism; D051841:Transcription Factor RelB / Q000378:metabolism; D000099181:Dectin-1
D037181:Lectins, C-Type; D019908:Proto-Oncogene Proteins c-raf; D051996:Transcription Factor RelA; D051841:Transcription Factor RelB; C546929:CLEC7A protein, human; D000099181:Dectin-1; C497593:RELB protein, human; C445340:dectin-2, mouse
BCML; BMDCs; BMM; Biological Connection Markup Language; C-type lectin like receptor; C-type lectins; CLR; Cytokines; DCs; Dendritic cells; IL; Immune response; PRR; Signalling pathway; TLR; Toll like receptor; bone marrow dendritic cells; bone marrow derived macrophages; dendritic cells; interleukin; moDCs; monocyte derived dendritic cells; pathogen recognition receptor