Prevention of UVB-induced production of the inflammatory mediator in human keratinocytes by lactic acid derivatives generated from aromatic amino acids.
The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA.
Functional Biomolecules Research Group, The Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization.
Ayako
A
Aoki-Yoshida
Kasumi
K
Ichida
Reiji
R
Aoki
Toshiyuki
T
Kawasumi
Chise
C
Suzuki
Yoshiharu
Y
Takayama
D024322:Amino Acids, Aromatic; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002460:Cell Line / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D015603:Keratinocytes / Q000187:drug effects* / Q000528:radiation effects; D010666:Phenylpropionates / Q000008:administration & dosage*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D014466:Ultraviolet Rays
D024322:Amino Acids, Aromatic; D000893:Anti-Inflammatory Agents; D007211:Indoles; D010666:Phenylpropionates; D012333:RNA, Messenger; C001418:4-hydroxyphenyllactic acid; C024139:indole-3-lactic acid