Quantum dots-based in situ molecular imaging of dynamic changes of collagen IV during cancer invasion.
Cancer invasion and metastasis remains the root cause of mortality. This process involves alterations of tumor microenvironment, particularly the remodeling of extracellular matrix, characterized by collagen IV uncoiling, degradation, fragments deposition and cross-linking. Quantum dots-labeled molecular probes are promising platforms to simultaneously study several subtle changes of key biomolecules, because of their unique optical and chemical properties. Here we report on a quantum dots-based imaging technology to study key components in tumor microenvironment during cancer progression, so as to gain new insights into the role of collagen IV plays, to define the cancer "invasion unit" and to develop the "pulse-mode" of cancer invasion.
Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, No. 169 Donghu Road, Wuchang District, Wuhan 430071, PR China.
Min
M
Fang
Jing-Ping
JP
Yuan
Chun-Wei
CW
Peng
Dai-Wen
DW
Pang
Yan
Y
Li
D024141:Collagen Type IV / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D045663:Quantum Dots; D059016:Tumor Microenvironment / Q000502:physiology
D024141:Collagen Type IV
Cancer invasion mode; Collagen IV; ECM remodeling; Multiplexed imaging; Quantum dots