Liver transplantation treating the patient with hepatic failure associated with sorafenib treatment: report of a case.
For the first time ever, sorafenib-induced hepatic failure has been cured by liver transplantation. A 54-year-old man, he underwent surgery for papillary carcinoma of thyroid gland two years ago. After two years follow up, a left neck lymph node metastasis was found and he was treated with sorafenib (800 mg/day). However, two days later, hepatic failure associated with sorafenib developed and he was treated with liver transplantation. The donor was a victim of road accident. Even though hepatic failure associated with sorafenib treatment is rare, the possible development of hepatic failure in patients undergoing sorafenib treatment must be kept in mind.
Jianhua
J
Rao
Min
M
Feng
Xiaofeng
X
Qian
Guoqiang
G
Li
Xuehao
X
Wang
Feng
F
Zhang
Ling
L
Lu
D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000009:adverse effects / Q000031:analogs & derivatives*; D010671:Phenylurea Compounds / Q000009:adverse effects*; D000077157:Sorafenib
D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D009536:Niacinamide; D000077157:Sorafenib