Evaluation of the mechanism of gelation of an oleogel based on a triterpene extract from the outer bark of birch.
Oleogels are known for their high physical, chemical, and mechanical stability and good in vivo efficacy, which make them appropriate vehicles for dermal drug delivery and skin care for very dry skin. Modern formulation research focusses on well tolerated and sustainable formulation concepts. This paper deals with an innovative oleogel, which is based on a triterpene dry extract from the outer bark of birch (TE). In this formulation TE does not only act as an excipient but provides interesting pharmacological properties at the same time. The oleogel was formulated using solely Simmondsia Chinensis seed oil (jojoba oil) and TE. Fluorescence microscopy and confocal Raman microscopy showed that suspended TE particles arrange in a three-dimensional gel network. Infrared spectroscopy revealed that the formation of hydrogen bonds between TE particles is responsible for the self-assembly of TE in oil. Moreover, the influence of TE concentration and morphology of the TE particles on the viscoelasticity of the resulting oleogels was analyzed. Gel strength increased with TE concentration and was critical to the specific surface area of the TE particles.
Pharmazeutische Technologie und Biopharmazie, Pharmazeutisches Institut, Universität Tübingen, Germany.
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M
Grysko
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R
Daniels
D029662:Betula / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D004655:Emulsions; D005782:Gels; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D009930:Organic Chemicals / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D012212:Rheology; D012997:Solvents; D017550:Spectroscopy, Fourier Transform Infrared; D014315:Triterpenes / Q000737:chemistry*; D014885:Waxes / Q000737:chemistry*; D014961:X-Ray Diffraction
D004655:Emulsions; D005782:Gels; D009930:Organic Chemicals; D010936:Plant Extracts; D012997:Solvents; D014315:Triterpenes; D014885:Waxes; C016021:oleogels; C034743:jojoba wax