Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds.
We have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[(18)F]fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[(18)F]fluoroaniline were achieved within 3 minutes.
Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, MA, USA 02114. vasdev.neil@mgh.harvard.edu.
Steven H
SH
Liang
Thomas Lee
TL
Collier
Benjamin H
BH
Rotstein
Rebecca
R
Lewis
Mia
M
Steck
Neil
N
Vasdev
D000814:Aniline Compounds / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006865:Hydrogenation; D046210:Microfluidic Analytical Techniques / Q000191:economics / Q000379:methods; D010084:Oxidation-Reduction; D011804:Quinolines / Q000737:chemistry*; D013997:Time Factors
D000814:Aniline Compounds; D005462:Fluorine Radioisotopes; D011804:Quinolines