Stability of Zidovudine and Dobutamine Hydrochloride Injections in 0.9% Sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 +/- 2 Deg C) and 4 Deg C in 50-mL Polyvinyl Chloride Bags Up to 24 Hours.
The stability of a 2-mg/mL zidovudine and 1-mg/mL dobutamine hydrochloride admixture stored in 0.9% sodium chloride and 5% dextrose injections in 50-mL polyvinyl chloride bags at ambient temperature (23 +/- 2 deg C) and 4 deg C for up to 24 hours was studied. The samples were analyzed at 0, 4, 8, and 24 hours after preparation of the controls and known mixtures by means of a reverse-phase stability indicating high-performance liquid chromatographic method. The drug mixtures were stable for up to 24 hours, as shown by the greater than 90% of initial concentrations at the time of preparation. The pH of the drug solutions remained constant in the pH 6 to 7 range. These data support the stability of the zidovudine and dobutamine admixture under the storage conditions studied.
Department of Pharamceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia.
Patrick
P
Musami
James T
JT
Stewart
E Will
EW
Taylor