Trichodysplasia spinulosa associated with lupus.
Trichodysplasia spinulosa (TS) is a unique clinical and histological entity described in immunosuppressed patients. The recent discovery of genomic DNA from a new Polyomavirus named trichodysplasia spinulosa-associated Polyomavirus in TS lesions and good clinical response to cidofovir strengthens the hypothesis of a viral etiology for the disease. The authors report a case of TS associated with lupus erythematosus in a 26-year-old woman with no history of transplant, hemopathy, or cyclosporine treatment. The patient developed a progressive worsening eruption composed of confluent papules and spiky filiform excrescences concentrated in the midfacial area. Pathological features were characterized by aberrant distended and abnormally maturated hair follicles with sheets of eosinophilic cells containing large purple granules, and the presence of trichodysplasia spinulosa-associated Polyomavirus DNA was confirmed by polymerase chain reaction. This case is the first description in a nontransplanted lupus patient without underlying hemopathy.
Departments of *Pathology and †Virology, Assistance Publique des Hôpitaux de Paris, Cochin Hospital, Paris, France; ‡Unit EA1833, Paris Descartes University, Paris, France; and §Department of Dermatology, Assistance Publique des Hôpitaux de Paris, Cochin Hospital, Paris, France.
Anissa
A
Moktefi
Hélène
H
Laude
Laurence
L
Brudy Gulphe
Flore
F
Rozenberg
Marie Cécile
MC
Vacher Lavenu
Nicolas
N
Dupin
Agnès
A
Carlotti
D000328:Adult; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006201:Hair Diseases / Q000150:complications* / Q000821:virology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000821:virology*; D027601:Polyomavirus Infections / Q000150:complications*; D060888:Real-Time Polymerase Chain Reaction
D004279:DNA, Viral