A life-style physical activity intervention and the antibody response to pneumococcal vaccination in women.
OBJECTIVE
To assess whether a life-style physical activity intervention improved antibody response to a pneumococcal vaccination in sedentary middle-aged women.


METHODS
Eighty-nine sedentary women completed a 16-week exercise (physical activity consultation, pedometer, telephone/e-mail prompts; n = 44) or control (advisory leaflet; n = 45) intervention. Pneumococcal vaccination was administered at 12 weeks, and antibody titers (11 of the 23 contained in the pneumococcal vaccine) were determined before vaccination and 4 weeks and 6 months later. Physical activity, aerobic fitness, body composition, and psychological factors were measured before and after the intervention.


RESULTS
The intervention group displayed a greater increase in walking behavior (from mean [standard deviation] = 82.16 [90.90] to 251.87 [202.13]) compared with the control condition (111.67 [94.64] to 165.16 [117.22]; time by group interaction: F(1,68) = 11.25, p = .001, η(2) = 0.14). Quality of life also improved in the intervention group (from 19.37 [3.22] to 16.70 [4.29]) compared with the control condition (19.97 [4.22] to 19.48 [5.37]; time by group interaction: F(1,66) = 4.44, p = .039, η(2) = 0.06). However, no significant effects of the intervention on antibody response were found (time by group η(2) for each of the 11 pneumococcal strains ranged from 0.001 to 0.018; p values all >.264).


CONCLUSIONS
Participation in a life-style physical activity intervention increased subjective and objective physical activity levels and quality of life but did not affect antibody response to pneumococcal vaccination.
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. j.e.long.1@bham.ac.uk.
Joanna E
JE
Long
Chris
C
Ring
Jos A
JA
Bosch
Francis
F
Eves
Mark T
MT
Drayson
Rebecca
R
Calver
Vanessa
V
Say
Daniel
D
Allen
Victoria E
VE
Burns
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000917:Antibody Formation / Q000276:immunology*; D001823:Body Composition / Q000502:physiology; D015444:Exercise / Q000502:physiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D010809:Physical Fitness / Q000502:physiology; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D011788:Quality of Life; D012907:Smoking / Q000453:epidemiology; D013315:Stress, Psychological / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014611:Vaccination; D016138:Walking / Q000502:physiology / Q000523:psychology
D022242:Pneumococcal Vaccines
antibody response; physical activity; pneumococcal vaccination