A case of late-onset systemic lupus erythematosus with severe anemia.
A 59-year-old woman was referred to our hospital because of severe anemia and leucopenia. Although she developed mild arthralgia without the typical symptoms of systemic lupus erythematosus (SLE), positivity for anti-Sm antibodies led us to a diagnosis of late-onset SLE. Autoimmune hemolytic anemia (AIHA) and suppression of reticulocyte production were considered to have been involved in the etiology of severe anemia. Administration of oral prednisolone (PSL) resulted in a marked improvement of the hematological abnormalities. As late-onset SLE is rare and patients tend to show the typical symptoms less frequently, close attention should be focused on latent symptoms and immunological findings.
Department of Medicine, Kurume University School of Medicine.
Moeko
M
Matsumoto
Shinjiro
S
Kaieda
Seiyo
S
Honda
Hiroaki
H
Ida
Tomoaki
T
Hoshino
Takaaki
T
Fukuda
D000284:Administration, Oral; D017668:Age of Onset; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D000974:Antibodies, Antinuclear / Q000097:blood; D018771:Arthralgia / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D055517:snRNP Core Proteins / Q000276:immunology
D000974:Antibodies, Antinuclear; D015415:Biomarkers; D005938:Glucocorticoids; D055517:snRNP Core Proteins; D011239:Prednisolone