Connectivity-based parcellation of the human temporal pole using diffusion tensor imaging.
The temporal pole (TP) is an association cortex capable of multisensory integration and participates in various high-order cognitive functions. However, an accepted parcellation of the human TP and its connectivity patterns have not yet been well established. Here, we sought to present a scheme for the parcellation of human TP based on anatomical connectivity and to reveal its subregional connectivity patterns. Three distinct subregions with characteristic fiber pathways were identified, including the dorsal (TAr), the medial (TGm), and lateral (TGl) subregions, which are located ventrally. According to the connectivity patterns, a dorsal/ventral sensory segregation of auditory and visual processing and the medial TGm involved in the olfactory processing were observed. Combined with the complementary resting-state functional connectivity analysis, the connections of the TGm with the orbitofrontal cortex and other emotion-related areas, the TGl connections with the MPFC and major default mode network regions, and the TAr connections with the perisylvian language areas were observed. To the best of our knowledge, the present study represents the first attempt to parcel the human TP based on its anatomical connectivity features, which may help to improve our understanding of its connectional anatomy and to extend the available knowledge in TP-related clinical research.
Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China.
Lingzhong
L
Fan
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, PR China.
Jiaojian
J
Wang
Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China.
Yu
Y
Zhang
Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, PR China.
Wei
W
Han
Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, PR China.
Chunshui
C
Yu
Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, PR China The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
Tianzi
T
Jiang
D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D012146:Rest; D013702:Temporal Lobe / Q000098:blood supply / Q000502:physiology*; D055815:Young Adult
D010100:Oxygen
connectivity; diffusion tensor imaging; parcellation; resting-state fMRI; temporal pole