Inhibiting inhibitory pathways in human γδ T cells.
In this issue of Blood, Gertner-Dardenne et al show that B- and T-lymphocyte attenuator (BTLA) functions as an inhibitory receptor on gd T cells and suggest that disruption of this inhibitory pathway in tumor-reactive gd T cells may result in enhanced antitumor responses.
University of Alabama at Birmingham.
Richard D
RD
Lopez
D015972:Gene Expression Regulation, Neoplastic; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D011971:Receptors, Immunologic / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
C482586:BTLA protein, human; D011971:Receptors, Immunologic