Fungal granulomatous interstitial nephritis presenting as acute kidney injury diagnosed by renal histology including PCR assay.
We describe two cases of fungal granulomatous interstitial nephritis (GIN) presenting as acute kidney injury (AKI). Increased serum creatinine was detected in Patient 1 after chemotherapy for pharyngeal cancer and in Patient 2 after steroid pulse therapy for bronchial asthma. Renal histology of both patients revealed GIN. Polymerase chain reaction (PCR)-based detection of fungal DNA sequences from kidney tissue demonstratedTrichosporon laibachiiandCandida albicans, respectively. When AKI occurs in an immunocompromised host, differential diagnosis of fungal interstitial nephritis should be considered. Furthermore, PCR-based detection of fungal DNA sequences from renal specimens can be useful for rapid diagnosis.
Division of Kidney and Hypertension, Department of Internal Medicine , The Jikei University School of Medicine , Tokyo , Japan.
Makoto
M
Ogura
Shino
S
Kagami
Masatsugu
M
Nakao
Midori
M
Kono
Yukiko
Y
Kanetsuna
Tatsuo
T
Hosoya
acute kidney injury; fungal granulomatous interstitial nephritis; polymerase chain reaction; trichosporon