Three novel xanthones from Garcinia paucinervis and their anti-TMV activity.
Phytochemical investigations of the leaves of Garcinia paucinervis resulted in the isolation of three new xanthones 1-3 and five known analogues 4-8. Structural elucidations of 1-3 were performed by spectral methods such as 1D and 2D (HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. Compounds 1-3 showed anti-TMV activities, with inhibition rates above 20%, especially for 1, which had a lower IC₅₀ value of 21.4 µM.
Yunnan Academy of Tobacco Agricultural Sciences, Yuxi 653100, China.
Yu-Ping
YP
Wu
Wei
W
Zhao
Zhen-Yuan
ZY
Xia
Guang-Hui
GH
Kong
Xiu-Ping
XP
Lu
Qiu-Fen
QF
Hu
Xue-Mei
XM
Gao
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D014027:Tobacco Mosaic Virus / Q000187:drug effects*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000998:Antiviral Agents; D044004:Xanthones