Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer.
Nemo-like kinase (NLK), a mediator of the Wnt signaling pathway, binds directly to c-Myb, leading to its phosphorylation, ubiquitination and proteasome-dependent degradation. NLK was significantly downregulated in the breast cancer tissues compared to corresponding normal tissues. NLK expression was negatively correlated with c-Myb expression. NLK suppressed proliferation, induced apoptosis and mediated c-Myb degradation in MCF-7 cells via a mechanism that seems to involve c-myc and Bcl2. These findings might provide a novel target for therapeutic intervention in patients with breast cancer.
Department of Tumor Chemotherapy, Affiliated Hospital of Nantong University, Medical College, Nantong University, Nantong, Jiangsu, China.
Yeqing
Y
Huang
Ying
Y
Jiang
Weiqi
W
Lu
Yong
Y
Zhang
D017209:Apoptosis; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology*; D002453:Cell Cycle; D049109:Cell Proliferation; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism; D061986:MCF-7 Cells; D008875:Middle Aged; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D059748:Proteolysis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D020598:Proto-Oncogene Proteins c-myb / Q000378:metabolism*
D047908:Intracellular Signaling Peptides and Proteins; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D020598:Proto-Oncogene Proteins c-myb; C470551:NLK protein, human; D017346:Protein Serine-Threonine Kinases