The role of beclin-1 expression in patients with gastric cancer: a meta-analysis.
Beclin-1 has been identified as a reliable biomarker in monitoring the prognosis for tumors. We carried out a meta-analysis focusing on the relationship between beclin-1 and the clinical characteristics of patients with gastric cancer. We identified articles in MEDLINE, PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases by using the following strategy: ("beclin 1" or "beclin-1" or "ATG6") and ("gastric cancer" or "stomach cancer"). We conducted a final analysis of 1,254 patients from seven studies. The pooled odds ratio (OR) indicated a significant association between beclin-1 expression and the differentiation of gastric cancer (pooled OR = 0.23; 95 % confidence interval (CI) = 0.07-0.73) or tumor-node-metastasis staging of gastric cancer (pooled OR = 0.62; 95 % CI = 0.48-0.79). Beclin-1 expression was different in intestinal- and diffuse-type gastric cancer (pooled OR = 0.55; 95 % CI = 0.39-0.77). No association between beclin-1 and tumor size (pooled OR = 0.73; 95 % CI = 0.45-1.17) or lymph node metastasis (pooled OR = 0.59; 95 % CI = 0.17-1.99) was observed.
Department of Biochemistry and Molecular Biology, School of Basic Medical Science, China Medical University, Shenyang, 110001, Liaoning, China, nn001007@163.com.
Pu
P
Xia
Jin-Jin
JJ
Wang
Bao-Bao
BB
Zhao
Chang-Liang
CL
Song
D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis*; D000071186:Beclin-1; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008565:Membrane Proteins / Q000096:biosynthesis*; D009367:Neoplasm Staging; D016017:Odds Ratio; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D047368:Tumor Burden; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis*
D051017:Apoptosis Regulatory Proteins; C491997:BECN1 protein, human; D000071186:Beclin-1; D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins