Experience with the Atrium Advanta covered stent for aortic obstruction.
BACKGROUND
We sought to assess the efficacy, safety and clinical outcomes of the Advanta V12™ covered stent in management of coarctation of the aorta (CoA).


METHODS
Stent functionality was assessed by review of angiographic imaging, clinical data at admission, discharge and at the last clinic visit, stent configuration on chest roentgenogram, radiation exposure, and complications.


RESULTS
Between October 2009 and February 2012, 17 patients underwent stent implantation. There were 9-12, 2-14, and 6-16 mm diameter stents deployed. Balloon angioplasty after implantation was required in 2 patients. Mean percent recoil in the middle of the stent for the 12, 14, and 16 mm implants was 14%, 24%, and 24%, respectively. There was improvement in CoA diameter from 6.6 ± 3.2 to 11.5 ± 1.7 mm (P<0.0001) and a reduction in the peak pressure gradient from 23.1 ± 10.1 to 0.8 ± 3.3 mmHg (P<0.0001). No patient had a symptomatic complication. Left arm cuff blood pressure fell 24 hours after implantation and left arm to leg blood pressure gradient fell to <20 mmHg in all (P<0.0001). Follow-up was a median 242 days and at the last clinic visit there were no statistically different findings from discharge. Five children (33%) required antihypertensive medications but 3 were off medication at latest follow-up. Three patients (18%) required reintervention.


CONCLUSIONS
The implantation of the Advanta™ V12 stent for the treatment of CoA is safe and effective in the early term. However, further study is required to determine longer-term stent efficacy.
Department of Pediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Naoki
N
Ohno
Rajiv
R
Chaturvedi
Kyong-Jin
KJ
Lee
Eric M
EM
Horlick
Mark D
MD
Osten
Lee N
LN
Benson
D000293:Adolescent; D000328:Adult; D001017:Aortic Coarctation / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D017023:Coronary Angiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods; D015607:Stents; D016896:Treatment Outcome; D055815:Young Adult