The H/Rouen mouse model displays depression-like and anxiety-like behaviors.
Cardinal symptoms of depression include helplessness and anhedonia. In addition, depression and anxiety are often comorbid disorders. H/Rouen mice, a genetic mouse model of depression, display helpless behavior in the tail suspension test, whereas non-helpless NH/Rouen mice show the opposite behavior. It is unknown whether H/Rouen mice display an anxious behavior as compared to NH/Rouen mice, and is unclear whether they display anhedonia. Time spent in the periphery of an open-field, an index of anxiety, was found to be higher in male and female H/Rouen mice as compared to NH/Rouen mice. In the elevated plus-maze, a decrease in the number of entries and in the time spent in the open arms was observed in both male and female H/Rouen. In the light/dark box, the number of entries and the time spent in the anxiogenic bright compartment was significantly reduced in male and female H/Rouen mice. In addition, the preference of consumption of a 2% sucrose solution was significantly reduced in male and female H/Rouen mice as compared to NH/Rouen and I/Rouen mice in a two-bottle choice paradigm but was restored by a chronic (3 weeks) fluoxetine treatment. H/Rouen mice thus display both anxiety and anhedonia making them a potent animal model in the treatment of forms depression comorbidly expressed with anxiety.
Lyon Neuroscience Research Center, CNRS UMR5292; INSERM U1028, Lyon F-69372, France; University of Lyon 1, Lyon F-69000, France. Electronic address: malika.el-yacoubi@univ-lyon1.fr.
Malika
M
El Yacoubi
Virginie
V
Rappeneau
Eddy
E
Champion
Gaël
G
Malleret
Jean-Marie
JM
Vaugeois
D059445:Anhedonia / Q000187:drug effects / Q000502:physiology; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D001007:Anxiety / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D015897:Comorbidity; D003866:Depressive Disorder / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D004195:Disease Models, Animal; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D005518:Food Preferences / Q000187:drug effects / Q000502:physiology; D008297:Male; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009483:Neuropsychological Tests; D013045:Species Specificity; D013395:Sucrose / Q000008:administration & dosage
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D013395:Sucrose
Anhedonia; Animal model; Anxiety; Depressive disorder; Mouse; Tail suspension test