Electroconvulsive therapy induces neurogenesis in frontal rat brain areas.
Electroconvulsive therapy (ECT) is an effective therapy for several psychiatric disorders, including severe major depression, mania and certain forms of schizophrenia. It had been proposed that ECT acts by modulating local plasticity via the stimulation of neurogenesis. In fact, among antidepressant therapies, ECT is the most robust enhancer of neurogenesis in the hippocampus of rodents and non-human primates. The existence of ECT-triggered neurogenesis in other brain areas, particularly in those adjacent to the other main locus of neurogenesis, the subventricular zone (SVZ), had so far remained unknown. Here we show that ECT also strongly enhances neurogenesis in frontal brain areas, especially in the rostro-medial striatum, generating specific, small-size calretinin-positive interneurons. We provide here the first evidence that ECT stimulates neurogenesis in areas outside the hippocampus. Our data may open research possibilities that focus on the plastic changes induced by ECT in frontal limbic circuitry.
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Dragos.Inta@zi-mannheim.de
Dragos
D
Inta
Juan M
JM
Lima-Ojeda
Thorsten
T
Lau
Wannan
W
Tang
Christof
C
Dormann
Rolf
R
Sprengel
Patrick
P
Schloss
Alexander
A
Sartorius
Andreas
A
Meyer-Lindenberg
Peter
P
Gass
D000818:Animals; D000831:Animals, Newborn; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count; D000089622:Doublecortin Domain Proteins; D004565:Electroconvulsive Therapy; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D007395:Interneurons / Q000378:metabolism / Q000473:pathology; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D017072:Neostriatum / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D055495:Neurogenesis; D009479:Neuropeptides / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D001973:Bromodeoxyuridine