Chlamydia pneumoniae and helicobacter pylori serology - importance in patients with coronary heart disease.
BACKGROUND
Chronic infections in CHD are due to one or both of the organisms Chlamydia pneumoniae and Helicobacter pylori.


OBJECTIVE
To examine the association between serum markers of Chlamydia pneumoniae and Helicobacter pylori infection and markers of myocardial damage. in patients with acute coronary syndrome (ACS), with chronic coronary artery disease (CAD) and in-control group.


METHODS
Sera were taken from a total of 153 subjects. Subjects were divided in three groups: 64 patients with ACS; 53 patients with CAD and a group of 35 conditionally healthy individuals. Analysis of patients' sera for IgG antibodies to H. pylori and markers for myocardial damage was done on the Immulite system. The presence of specific IgG and IgA antibodies to C. pneumoniae was determined with MIF, Sero FIA (Savyon Diagnostics, Israel). Statistical analysis of data was done using the statistical program SPSS (Statistical Package for Social Sciences), version 13.


CONCLUSIONS
There was a high significant difference in troponin levels between the three groups of subjects (p=0.0000). Levels of creatine kinase isoenzyme (CK-MB) were highest in the ACS group (500.0 ng/mL). There was a statistically significant difference between CG subjects and ACS patients due to more frequent detection of antichlamydial IgA antibodies in patients with acute coronary syndrome. Positive serum immune response for Helicobacter pylori was 17 (53.1%) and 29 (80.6%), respectively.


CONCLUSIONS
Increased IgA antibody titers for C. Pneumoniae, increased CRP values as well as classic markers of myocardial damage are risk factors for coronary events.
Institute of Microbiology and Parasitology.
Tatjana
T
Grdanoska
Planinka
P
Zafirovska
Branko
B
Jaglikovski
Irina
I
Pavlovska
Beti
B
Zafirova
Katerina
K
Tosheska-Trajkovska
Elena
E
Trajkovska-Dokic
Milena
M
Petrovska
Zhaklina
Z
Cekovska
Irena
I
Kondova-Topuzovska
Ljubica
L
Georgievska-Ismail
Nikola
N
Panovski
Chlamydia pneumoniae and Helicobacter pylori.; chronic infections; markers of cardiac damage