Molecular imprinted magnetic nanoparticles for controlled delivery of mitomycin C.
Controlled drug delivery system is a technique which has considerable recent potential in the fields of pharmacy and medicine. Mitomycin C is commonly used drug in the treatment of superficial bladder and breast cancers. In the present study, mitomycin C-imprinted magnetic poly(hydroxyethyl methacrylate)-based nanoparticles (MIMNs) were prepared using surfactant free emulsion polymerization for controlled delivery of mitomycin C. The MIMNs were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, electron spin resonance, and elemental analysis. The average particle diameter of MIMNs was about 200 nm.
Division of Biochemistry , Department of Chemistry, Hacettepe University , Ankara , Turkey.
Deniz
D
Türkmen
Nilay
N
Bereli
M Emin
ME
Çorman
Huma
H
Shaikh
Sinan
S
Akgöl
Adil
A
Denizli
D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D016685:Mitomycin / Q000737:chemistry*; D054802:Molecular Imprinting; D013696:Temperature
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D016685:Mitomycin
C delivery; PHEMA; mitomycin; molecular imprinting; nanoparticles