Immune response after a single dose of the 2010/11 trivalent, seasonal influenza vaccine in HIV-1-infected patients and healthy controls.
BACKGROUND
Immune response rates following influenza vaccination are often lower in HIV-infected individuals. Low vitamin D levels were correlated with weak immune response in cancer patients and are known to be lower in HIV-infected patients.


METHODS
Diagnostic study to determine immune response against the H1N1v component after a single, intramuscular dose of the 2010/11 seasonal, trivalent influenza vaccine (TIV) in adult HIV-infected and healthy controls scheduled for influenza vaccination (ClinicalTrials.gov Identifier: NCT01017172). Influenza A/H1N1 antibody titers (AB) were determined before and 21 days after vaccination by hemagglutination inhibition assay.


RESULTS
Immune response was not different between HIV-infected patients (n = 36) and healthy controls (n = 42) who were previously naïve to the H1N1v component of the TIV. Comparing HIV-infected patients (n = 55) and healthy controls (n = 63) who had received 1 or 2 doses of an AS03 adjuvanted H1N1 vaccine in the previous winter season (2009/10), seroconversion rate and the geometric mean AB titer after TIV of the HIV-infected patients were more than twice as high compared to healthy controls. This difference was mainly driven by the 2-dose schedule for HIV patients in 2009/10. Vitamin D levels were lower in HIV patients but did not correlate with immune response.


CONCLUSIONS
HIV-infected patients who had received 1 or 2 doses of an adjuvanted H1N1 vaccine in the previous year (2009/10) had a significant higher seroconversion rate following TIV as compared to healthy controls, indicating a stronger memory cell response due to the 2-dose schedule.
Department of Infectious Disease, JW Goethe University, Frankfurt, Germany. markus.bickel@hivcenter.de
Markus
M
Bickel
Christin
C
Lassmann
Imke
I
Wieters
Hans Wilhelm
HW
Doerr
Eva
E
Herrmann
Sabine
S
Wicker
Hans Reinhard
HR
Brodt
Christoph
C
Stephan
Regina
R
Allwinn
Oliver
O
Jung
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D015497:HIV-1; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D007252:Influenza Vaccines