Highly efficient construction of bisspirooxindoles containing vicinal spirocenters through an organocatalytic modified Feist-Bénary reaction.
We have developed an organocatalytic modified Feist-Bénary reaction of cyclic dicarbonyl compounds, isatins and cyclic α-bromo dicarbonyl compounds. This method affords bisspirooxindole-fused dihydrofurans containing two vicinal spiro centers. To the best of our knowledge, employing cyclic α-halo dicarbonyl compounds for the synthesis of bisspirooxindole-fused dihydrofurans has not been previously reported.
Department of chemistry, Shahid Beheshti University, Tehran 1983963113 (Iran), Fax: (+98) 21-22431661.
Somayeh
S
Ahadi
Hamid Reza
HR
Khavasi
Ayoob
A
Bazgir
D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D007211:Indoles; D013141:Spiro Compounds
Feist-Bénary reaction; fused-ring systems; organocatalysis; spiro compounds; synthetic methods