Impact of colonization pressure and strain type on methicillin-resistant Staphylococcus aureus transmission in children.
We studied the transmissibility of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and healthcare-associated methicillin-resistant S. aureus (HA-MRSA) strains and the association of MRSA colonization pressure and MRSA transmission in critically ill children. Importantly, we found that in hospitalized children MRSA colonization pressure above 10% increases the risk of MRSA transmission 3-fold, and CA-MRSA and HA-MRSA strains have similar transmission dynamics.
Division of Pediatric Infectious Diseases, Department of Pediatrics.
Victor O
VO
Popoola
Karen C
KC
Carroll
Tracy
T
Ross
Nicholas G
NG
Reich
Trish M
TM
Perl
Aaron M
AM
Milstone
D002353:Carrier State; D016009:Chi-Square Distribution; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000382:microbiology / Q000635:transmission; D003428:Cross Infection / Q000382:microbiology* / Q000635:transmission*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics / Q000302:isolation & purification*; D009296:Nasal Cavity / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000635:transmission*
colonization pressure; healthcare-associated infections; intensive care unit; methicillin-resistant Staphylococcus aureus; transmission