Parathyroid hormone has an important role in blood pressure regulation in vitamin D-insufficient individuals.
OBJECTIVE
The aim of the present study was to evaluate whether vitamin D status is related to blood pressure (BP) in adults.


METHODS
We evaluated the relationship between vitamin D status, intact parathyroid hormone (iPTH) and BP in 332 adults. Anthropometric measurements, BP, and a fasting blood sample was obtained. Participants were stratified into the following BP categories: 1) normal BP; 2) high BP; 3) normal BP through medication. Vitamin D insufficiency was defined as 25-hydroxvitamin D ≤ 75 nmol/L; high iPTH as > 65 pg/mL. The relationships between vitamin D status, iPTH and BP were adjusted for body mass index, waist circumference, blood lipids, physical activity, and sunscreen use.


RESULTS
No differences in prevalences of vitamin D insufficiency and high iPTH were observed among BP groups. No significant association was observed between BP and vitamin D status. Positive correlations were observed between iPTH and systolic BP (r = 0.168; P = 0.002) and between iPTH and diastolic BP (r = 0.168; P = 0.002). iPTH remained correlated with BP even with adjustments.


CONCLUSIONS
The present study contributes to the understanding of calcemic hormones and BP regulation.
Nutrition Department, School of Public Health, University of Sao Paulo, Brazil.
Vivian Cristina
VC
Garcia
Natielen Jacques
NJ
Schuch
Antonela Siqueira
AS
Catania
Sandra Roberta
SR
Gouvea Ferreira
Lígia Araújo
LA
Martini
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D001827:Body Height; D015992:Body Mass Index; D001938:Brazil; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005215:Fasting; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009752:Nutritional Status; D010281:Parathyroid Hormone / Q000097:blood*; D015995:Prevalence; D014280:Triglycerides / Q000097:blood; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000188:drug therapy; D055105:Waist Circumference
D001786:Blood Glucose; D010281:Parathyroid Hormone; D014280:Triglycerides; D014807:Vitamin D; D002784:Cholesterol; D003404:Creatinine
Blood pressure; Cardiovascular disease; Hypertension; Parathyroid hormone; Vitamin D