Low dose of amino-modified nanoparticles induces cell cycle arrest.
The interaction of nanoscaled materials with biological systems is currently the focus of a fast-growing area of investigation. Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle progression is arrested. In this scenario, nanoparticle uptake, which we have recently shown to be affected by cell cycle progression, develops differently over time due to the absence of cell division. This suggests that the same nanoparticles can trigger different pathways depending on exposure conditions and the dose accumulated.
Centre for BioNano Interactions, School of Chemistry and Chemical Biology & UCD, Conway Institute for Biomolecular and Biomedical Research, University College Dublin , Belfield, Dublin 4, Ireland.
Jong Ah
JA
Kim
Christoffer
C
Åberg
Guillermo
G
de Cárcer
Marcos
M
Malumbres
Anna
A
Salvati
Kenneth A
KA
Dawson
D059447:Cell Cycle Checkpoints / Q000187:drug effects* / Q000502:physiology; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D009584:Nitrogen / Q000737:chemistry* / Q000633:toxicity*; D011137:Polystyrenes / Q000737:chemistry* / Q000633:toxicity*; D020545:Respiratory Mucosa / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology
D011137:Polystyrenes; D009584:Nitrogen