Abietane diterpenes from Hyptis suaveolens.
Investigation of the constituents of the whole plant of Hyptis suaveolens led to the isolation of three new abietane diterpenes, isosuaveolic acid (1), 8α,9α-epoxysuaveolic acid (2), and 14-O-methylsuaveolic acid (3), together with eleven known compounds. The structures of 1-3 were established by spectroscopic methods and chemical correlations. Some isolates were tested for their antimycobacterial and cytotoxic activities.
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
Saowanee
S
Prawatsri
Apichart
A
Suksamrarn
Anon
A
Chindaduang
Thitima
T
Rukachaisirikul
D045784:Abietanes / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D031331:Hyptis / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology
C586889:8,9-epoxy-14-hydroxyabietan-18-oic acid 4a,10a-epoxy-dodecahydro-1-hydroxy-4b,8-dimethyl-2-(1-methylethyl)phenanthrene-8-carboxylic acid; D045784:Abietanes; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D028321:Plant Preparations
Abietanes; Antimycobacterial activity; Cytotoxic activity; Diterpenes; Hyptis suaveolens