Separacenes A-D, novel polyene polyols from the marine actinomycete, Streptomyces sp.
Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C-D (3-4) possess a triene moiety between two diol substructures. Separacenes A-D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Korea. baemoon89@snu.ac.kr
Munhyung
M
Bae
Heegyu
H
Kim
Yoonho
Y
Shin
Byung Yong
BY
Kim
Sang Kook
SK
Lee
Ki-Bong
KB
Oh
Jongheon
J
Shin
Dong-Chan
DC
Oh
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D045325:HCT116 Cells; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056910:Republic of Korea; D013057:Spectrum Analysis; D013302:Streptomyces / Q000737:chemistry*
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011090:Polyenes; D011108:Polymers; C024617:polyol