Long-range control of T-cell development.
In this issue of Blood, Li et al reveal the genetic elements that control the activity of Bcl11b, a critical regulator of T-cell development. Lineage-defining transcription factors (TFs), such as Bcl11b, control key steps in cellular differentiation throughout development, and understanding how these TFs are themselves regulated represents a major challenge.
Max Planck Institute of Immunobiology And Epigenetics.
Dominic
D
van Essen
D000818:Animals; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D012097:Repressor Proteins / Q000235:genetics*; D013601:T-Lymphocytes / Q000166:cytology*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
C511143:Bcl11b protein, mouse; D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins