Microwave effect on catalytic enantioselective Claisen rearrangement.
Catalytic enantioselective Claisen rearrangement was drastically enhanced under microwave irradiation conditions without any loss of the enantioselectivity. Based on Arrhenius plots it was revealed that enantioselectivity decreased as the internal reaction temperature increased. Therefore, this reaction acceleration would NOT be caused by only a simple thermal effect.
Department of Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. yamada@chem.keio.ac.jp.
Kazuya
K
Nushiro
Satoshi
S
Kikuchi
Tohru
T
Yamada