A general, practical palladium-catalyzed cyanation of (hetero)aryl chlorides and bromides.
Playing it safe: The nontoxic cyanide source K4 [Fe(CN)6]·3H2O can be used for the cyanation of (hetero)aryl halides. The application of palladacycle catalysts prevents poisoning during catalyst formation, thereby allowing for low catalyst loadings, fast reaction times, and wide heterocyclic substrate scope.
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA).
Todd D
TD
Senecal
Wei
W
Shu
Stephen L
SL
Buchwald
D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D003486:Cyanides; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D001965:Bromides; D002712:Chlorides; D003486:Cyanides; D010165:Palladium
cross-coupling; cyanides; heterocycles; homogeneous catalysis; palladium