A novel potassium oxalate-containing tooth-desensitising mouthrinse: a comparative in vitro study.
OBJECTIVE
To compare the efficacy of a new potassium oxalate (KO)-containing mouthrinse [Listerine® Advanced Defence Sensitive (LADS)] in reducing dentine permeability and occluding open dentinal tubules versus other desensitising products.


METHODS
The permeability of acid-etched dentine disks was measured by hydraulic conductance; dentine surfaces were examined by scanning electron microscopy and energy-dispersive X-ray spectroscopy. The KO concentration was optimised for tubule occlusion by screening formulations containing 0.0-2.0% KO (n=5 disks per concentration). The optimal formulation was compared with five commercial products with non-oxalate occlusion technologies. After establishing the baseline permeability of acid-etched dentine disks, disks (n=6 per product) were randomly treated with the desensitising products (12 treatments, each 60 s, alternated with distilled-water rinses) and permeability was measured at intervals. Occluded disks were acid challenged. All experiments were conducted at room temperature. An unpooled, two-tailed t test was performed to assess between-treatment differences in relative residual permeability.


RESULTS
The optimal concentration of KO in LADS was 1.4%, which provided ≈ 100% reduction in dentine permeability after nine treatments. Only LADS reduced permeability to zero and was significantly more effective in reducing dentine permeability than the other products (p ≤ 0.033 vs all other test products). All products partially occluded dentine. The occlusion associated with LADS was substantially more stable in resisting acid challenge versus Colgate® Sensitive Pro-Relief mouthrinse (p=0.054) and significantly more stable versus all other test products (p ≤ 0.045), as determined by dentine permeability.


CONCLUSIONS
LADS was significantly more effective in occluding open dentinal tubules versus other desensitising products.


CONCLUSIONS
LADS provides fast, complete and stable intratubular occlusion of patent dentinal tubules.
Oral Care Research and Development, Johnson & Johnson Consumer & Personal Products Worldwide, Skillman, NJ 08558, USA. DSharma6@its.jnj.com
Deepak
D
Sharma
Christopher X
CX
Hong
Paul S
PS
Heipp
D000085:Acetates / Q000627:therapeutic use; D000134:Acid Etching, Dental / Q000379:methods; D019412:Anatomy, Cross-Sectional; D001120:Arginine / Q000627:therapeutic use; D002119:Calcium Carbonate / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D019343:Citric Acid / Q000494:pharmacology; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D057133:Dentin Desensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D003806:Dentin Permeability / Q000187:drug effects; D005459:Fluorides / Q000627:therapeutic use; D005898:Glass; D006801:Humans; D019344:Lactic Acid / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D019815:Oxalic Acid / Q000737:chemistry / Q000627:therapeutic use*; D010710:Phosphates / Q000627:therapeutic use; D016369:Smear Layer; D013052:Spectrometry, X-Ray Emission; D013324:Strontium / Q000627:therapeutic use; D013997:Time Factors; D014002:Tin Fluorides / Q000627:therapeutic use; D014077:Tooth Erosion / Q000503:physiopathology; D014100:Toothpastes / Q000627:therapeutic use
D000085:Acetates; D057133:Dentin Desensitizing Agents; D009067:Mouthwashes; C510984:NovaMin; D010710:Phosphates; D014002:Tin Fluorides; D014100:Toothpastes; C585805:pro-argin; D019343:Citric Acid; D019344:Lactic Acid; C106741:strontium acetate; D001120:Arginine; D019815:Oxalic Acid; D002119:Calcium Carbonate; D005459:Fluorides; D013324:Strontium
Dentine; Dentine sensitivity; Hydraulic conductance; Potassium oxalate mouthrinse; Tubule occlusion