8-Aminoquinoline: a powerful directing group in metal-catalyzed direct functionalization of C-H bonds.
Chelate me if you can: Over the last decade, strategies for the functionalization of both C(sp2)-H and C(sp3)-H bonds have witnessed an increasing use of a simple, yet powerful directing group, 8-aminoquinoline (in blue). This auxiliary is very efficient in a wide range of metal-mediated reactions, and can be readily removed to afford the desired carboxylic acids or corresponding derivatives.
Eco-Efficient Products & Processes Laboratory (E2P2L) Solvay/CNRS UMI 3464, Solvay Research & Innovation Center Shanghai, 3966 Jindu Road, Xinzhuang Industrial Zone, Shanghai 201108 (P. R. China) http://www.solvay.com. matthieu.corbet@solvay.com.
Matthieu
M
Corbet
Floryan
F
De Campo
CH activation; chelates; heterocycles; palladium; synthetic methods