Potential cost-effectiveness of pneumococcal conjugate vaccine (PCV) in Turkey.
BACKGROUND
Pneumococcal infection is an important and preventable cause of morbidity and mortality. The Turkish government introduced 7-valent pneumococcal conjugate vaccine (PCV) into the national immunization program in 2009. This suggests that replacing 7-valent PCV with a higher-valent version could at least maintain "standard of care" if not improve it, and that it could be affordable.


OBJECTIVE
The aim of this analysis was to assess the potential direct cost-effectiveness of 13-valent PCV in Turkey, a country with a birth cohort of 1.4 million, against a "no vaccine" state, against the default 7-valent PCV state, and against a 10-valent PCV state, using a published cohort model with a 5-year horizon.


CONCLUSIONS
The cost per life-year gained is below the 1 × per-capita gross domestic product threshold across large changes in key input parameters, indicating that the model is stable and suggesting that any PCV would be very cost-effective in a Turkish national pediatric immunization schedule.
Department of Pediatrics and Pediatric Infectious Diseases, Bezmialem Vakif University, Adnan Menderes Bulvan Vatan Caddessi, Fatih, Istanbul, Turkey.
Ozden
O
Türel
Adnan
A
Kisa
E David G
ED
McIntosh
Mustafa
M
Bakir
D003362:Cost-Benefit Analysis; D006801:Humans; D017589:Immunization Programs / Q000191:economics; D011008:Pneumococcal Infections / Q000191:economics / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000191:economics*; D014421:Turkey; D018074:Vaccines, Conjugate / Q000008:administration & dosage* / Q000191:economics*
D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
burden of disease; children; cost-effectiveness; pneumonia; vaccines