Wrinkle reduction in post-menopausal women consuming a novel oral supplement: a double-blind placebo-controlled randomized study.
OBJECTIVE
The maintenance of youthful skin appearance is strongly desired by a large proportion of the world's population. The aim of the present study was therefore to evaluate the effect on skin wrinkling, of a combination of ingredients reported to influence key factors involved in skin ageing, namely inflammation, collagen synthesis and oxidative/UV stress. A supplemented drink was developed containing soy isoflavones, lycopene, vitamin C and vitamin E and given to post-menopausal women with a capsule containing fish oil.


METHODS
We have performed a double-blind randomized controlled human clinical study to assess whether this cocktail of dietary ingredients can significantly improve the appearance of facial wrinkles.


RESULTS
We have shown that this unique combination of micronutrients can significantly reduce the depth of facial wrinkles and that this improvement is associated with increased deposition of new collagen fibres in the dermis.


CONCLUSIONS
This study demonstrates that consumption of a mixture of soy isoflavones, lycopene, vitamin C, vitamin E and fish oil is able to induce a clinically measureable improvement in the depth of facial wrinkles following long-term use. We have also shown, for the first time with an oral product, that the improvement is associated with increased deposition of new collagen fibres in the dermis.
Unilever R&D, Colworth Discover, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, U.K.
G
G
Jenkins
Unilever R&D, Colworth Discover, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, U.K.
L J
LJ
Wainwright
Unilever R&D, Colworth Discover, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, U.K.
R
R
Holland
Unilever R&D, Colworth Discover, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, U.K.
K E
KE
Barrett
Unilever R&D, Colworth Discover, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, U.K.
J
J
Casey
D000284:Administration, Oral; D000368:Aged; D001205:Ascorbic Acid / Q000008:administration & dosage; D002338:Carotenoids / Q000008:administration & dosage; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage; D000077276:Lycopene; D008875:Middle Aged; D010349:Patient Compliance; D010919:Placebos; D017698:Postmenopause; D015595:Skin Aging / Q000187:drug effects*; D014810:Vitamin E / Q000008:administration & dosage
D005395:Fish Oils; D007529:Isoflavones; D010919:Placebos; D014810:Vitamin E; D002338:Carotenoids; D001205:Ascorbic Acid; D000077276:Lycopene
collagen synthesis; oral supplement; post-menopausal women; skin physiology; wrinkle reduction