Marine n-3 fatty acids in adipose tissue and development of atrial fibrillation: a Danish cohort study.
OBJECTIVE
Consumption of fish and marine n-3 polyunsaturated fatty acids (PUFA) may be associated with a lower risk of atrial fibrillation (AF), but results have been inconsistent. The aim was to investigate this further by measurements of marine n-3 PUFA in adipose tissue.


METHODS
Cohort study.


METHODS
A total of 57 053 Danish participants 50-64 years of age were enrolled into the Diet, Cancer and Health Cohort Study.


METHODS
A randomly drawn subcohort of 3440 participants with available data from baseline adipose tissue biopsies.


METHODS
Exposure was the adipose tissue content of marine n-3 PUFA, which reflects the endogenous exposure and is also an objective marker of the long-term dietary intake.


METHODS
Incident AF during follow-up.


RESULTS
179 cases of AF occurred over 13.6 years. Multivariate, sex-stratified Cox proportional hazards regression analyses using cubic splines showed a monotonic, negative, dose-response trend, but not statistically significant association, between total marine n-3 PUFA in adipose tissue and incident AF. A similar trend towards a lower risk of AF was seen in the second (HR 0.87, 95% CI 0.60 to 1.24) and third tertiles (HR 0.77, 95% CI 0.53 to 1.10) of marine n-3 PUFA compared with the lowest tertile. Similar trends, but also not statistically significant, were found separately for eicosapentaenoic, docosahexaenoic and docosapentaenoic acids.


CONCLUSIONS
There was no statistically significant association between the content of marine n-3 PUFA in adipose tissue and the development of AF; however, data showed a monotonic, negative dose-response trend suggestive of a negative association.
Department of Cardiology, Aalborg AF Study Group, Center for Cardiovascular Research, Aalborg University Hospital, , Aalborg, Denmark.
Thomas Andersen
TA
Rix
Albert Marni
AM
Joensen
Sam
S
Riahi
Søren
S
Lundbye-Christensen
Kim
K
Overvad
Erik Berg
EB
Schmidt
D000273:Adipose Tissue / Q000737:chemistry*; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D015415:Biomarkers; D001706:Biopsy; D003718:Denmark / Q000453:epidemiology; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D015525:Fatty Acids, Omega-3 / Q000032:analysis* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D012189:Retrospective Studies; D017747:Seafood
D015415:Biomarkers; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3