SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans.
Simian immunodeficiency virus (SIV) infection of Indian-origin rhesus macaques (RM) has been widely used as a well-established nonhuman primate (NHP) model for HIV/AIDS research. However, there have been a growing number of studies using Chinese RM to evaluate immunopathogenesis of SIV infection. In this paper, we have for the first time reviewed and discussed the major publications related to SIV or SHIV infection of Chinese RM in the past decades. We have compared the differences in the pathogenesis of SIV infection between Chinese RM and Indian RM with regard to viral infection, immunological response, and host genetic background. Given AIDS is a disease that affects humans of diverse origins, it is of importance to study animals with different geographical background. Therefore, to examine and compare results obtained from RM models of Indian and Chinese origins should lead to further validation and improvement of these animal models for HIV/AIDS research.
The Center for Animal Experiment/ ABSL-III Laboratory, State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan, Hubei 430071, P,R, China.
Yu
Y
Zhou
Rong
R
Bao
Nancy L
NL
Haigwood
Yuri
Y
Persidsky
Wen-zhe
WZ
Ho
D000818:Animals; D004195:Disease Models, Animal; D006678:HIV / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000472:pathogenicity*