Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines.
A rapid urea radiolabelling methodology has been developed. [(11)C]CO2 was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric (11)C radiolabelled ureas in high radiochemical yields.
Division of Imaging Sciences and Biomedical Engineering, King's College London, UK SE1 7EH.
Abdul Karim
AK
Haji Dheere
Nadiya
N
Yusuf
Antony
A
Gee
D000588:Amines / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry*; D002250:Carbon Radioisotopes / Q000737:chemistry; D015394:Molecular Structure; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D000588:Amines; D002250:Carbon Radioisotopes; D002245:Carbon Dioxide; D014508:Urea