Resilience to childhood maltreatment is associated with increased resting-state functional connectivity of the salience network with the lingual gyrus.
The experience of childhood maltreatment is related to an increased risk of developing a variety of psychiatric disorders, as well as a change in the structure of the brain. However, not much is known about the neurobiological basis of resilience to childhood maltreatment. This study aims to identify resting-state functional connectivity (RSFC) patterns specific for resilience to childhood maltreatment, focusing on the default mode and salience network and networks seeded from the amygdala and left dorsomedial prefrontal cortex. Resting-state functional MRI scans were obtained in 33 individuals. Seeds in the bilateral amygdala, the dorsal anterior cingulate cortex (dACC), the posterior cingulate cortex and the left dorsomedial prefrontal cortex were defined and used to examine whether resilient individuals differed from vulnerable individuals and healthy controls in RSFC with other brain regions. Within the salience network, the resilient group was associated with increased RSFC between the left dACC and a region containing the bilateral lingual gyrus and the occipital fusiform gyrus compared to both the vulnerable group and the healthy controls. In this study, we found RSFC patterns specific for resilient individuals. Regions that are implicated are related on a functional level to declarative memory and the processing of emotional stimuli.
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Steven J A
SJ
van der Werff
J Nienke
JN
Pannekoek
Ilya M
IM
Veer
Marie-José
MJ
van Tol
André
A
Aleman
Dick J
DJ
Veltman
Frans G
FG
Zitman
Serge A R B
SA
Rombouts
Bernet M
BM
Elzinga
Nic J A
NJ
van der Wee
D000328:Adult; D001931:Brain Mapping; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D011594:Psychometrics; D055500:Resilience, Psychological; D012189:Retrospective Studies
Childhood maltreatment; Lingual gyrus; Resilience; Resting-state functional connectivity