Controlled drug loading and release of a stimuli-responsive lipogel consisting of poly(N-isopropylacrylamide) particles and lipids.
Environmentally responsive materials are attractive for advance biomedicine applications such as controlled drug delivery and gene therapies. Recently, we have introduced the fabrication of a novel type of stimuli-sensitive lipogel composite consisting of poly(N-isopropylacrylamide) (pNIPAM) microgel particles and lipids. In this study, we demonstrated the temperature-triggered drug release behavior and the tunable drug loading and release capacities of the lipogel. At room temperature (22 °C), no calcein was released from the lipogel over time. At body temperature (37 °C), the release process was significantly promoted; lipids in the lipogel acted as drug holders on the pNIPAM scaffold carrier and prolonged the calcein release process from 10 min to 2 h. Furthermore, the loading and release of calcein could be effectively controlled by modulating the relative amount of lipids incorporated in the lipogel, which can be realized by the salt-induced lipid release of the lipogel.
Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou 215006, P R China.
Naiyan
N
Lu
Kai
K
Yang
Jingliang
J
Li
Yuyan
Y
Weng
Bing
B
Yuan
Yuqiang
Y
Ma
D000180:Acrylic Resins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005452:Fluoresceins / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*; D013696:Temperature
D000180:Acrylic Resins; D004337:Drug Carriers; D005452:Fluoresceins; D005782:Gels; D008055:Lipids; C052970:poly-N-isopropylacrylamide; C007740:fluorexon