Distinct cancer-specific survival in metastatic prostate cancer patients classified by a panel of single nucleotide polymorphisms of cancer-associated genes.
Individual genetic variations may have a significant influence on the survival of metastatic prostate cancer (PCa) patients. We aimed to identify target genes and their variations involved in the survival of PCa patients using a single nucleotide polymorphism (SNP) panel. A total of 185 PCa patients with bone metastasis at the initial diagnosis were analyzed. Germline DNA in each patient was genotyped using a cancer SNP panel that contained 1,421 SNPs in 408 cancer-related genes. SNPs associated with survival were screened by a log-rank test. Fourteen SNPs in 6 genes, XRCC4, PMS1, GATA3, IL13, CASP8, and IGF1, were identified to have a statistically significant association with cancer-specific survival. The cancer-specific survival times of patients grouped according to the number of risk genotypes of 6 SNPs selected from the 14 SNPs differed significantly (0-1 v. 2-3 v. 4-6 risk genotypes; P = 7.20 × 10(-8)). The high-risk group was independently associated with survival in a multivariate analysis that included conventional clinicopathological variables (P = 0.0060). We identified 14 candidate SNPs in 6 cancer-related genes, which were associated with poor survival in patients with metastatic PCa. A panel of SNPs may help predict the survival of those patients.
Department of Urology, Akita University Graduate School of Medicine, Akita, Japan.
Norihiko
N
Tsuchiya
Shigeyuki
S
Matsui
Shintaro
S
Narita
Tomomi
T
Kamba
Koji
K
Mitsuzuka
Shingo
S
Hatakeyama
Yohei
Y
Horikawa
Takamitsu
T
Inoue
Seiichi
S
Saito
Chikara
C
Ohyama
Yoich
Y
Arai
Osamu
O
Ogawa
Tomonori
T
Habuchi
bone metastasis; prostate cancer; single nucleotide polymorphism; survival