Breakthrough varicella in a cancer patient with persistent varicella antibody after one varicella vaccination.
A boy with Hodgkin disease contracted breakthrough varicella from his father, who had chickenpox. The boy had received a single varicella vaccination and was seropositive by enzyme-linked immunosorbent assay before being diagnosed with breakthrough varicella. Seropositivity after a single varicella vaccination does not guarantee complete protection in an immunocompromised child.
Divisions of Infectious Diseases/Virology and Hematology/Oncology, Children's Hospital, University of Iowa, Iowa City, IA.
Masaki
M
Yamada
Natalie
N
Kamberos
Charles
C
Grose
D000914:Antibodies, Viral / Q000097:blood; D002644:Chickenpox / Q000150:complications* / Q000517:prevention & control; D019433:Chickenpox Vaccine / Q000008:administration & dosage*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D014645:Herpesvirus 3, Human / Q000276:immunology; D006689:Hodgkin Disease / Q000150:complications* / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D007074:Immunoglobulin G / Q000097:blood; D008297:Male
D000914:Antibodies, Viral; D019433:Chickenpox Vaccine; D007074:Immunoglobulin G
ELISA; Enzyme-linked immunosorbent assay; IV; Intravenous; VZV; Varicella zoster virus