Role of integrins in the periodontal ligament: organizers and facilitators.
The periodontal ligament is the tissue that connects teeth to bone. The periodontal ligament is a fascinating tissue from a cell biologist's point of view, and because of its special properties and stem-cell content it has also come into the limelight in emerging fields of regenerative medicine. An increased range of genetically modified mouse models offer new tools for studying molecular mechanisms of tooth development. However, owing to species-specific organization of the tooth apparatus, the use of genetic animal models to study the role of the periodontal ligament in normal human tooth physiology and tooth pathology is challenging.
Malgorzata
M
Barczyk
Anne Isine
AI
Bolstad
Donald
D
Gullberg
D000818:Animals; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology*; D023421:Models, Animal; D009805:Odontogenesis / Q000502:physiology; D010513:Periodontal Ligament / Q000166:cytology / Q000502:physiology*; D038981:Receptors, Collagen / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000502:physiology
D016326:Extracellular Matrix Proteins; D016023:Integrins; D038981:Receptors, Collagen; C467800:integrin alpha11beta1