A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance.
Department of Tumor Biology, Institute of Biomedical Science, Iwate Medical University, Iwate, Japan; Department of Dermatology, Iwate Medical University, Iwate, Japan.
Shinpei
S
Miura
Department of Tumor Biology, Institute of Biomedical Science, Iwate Medical University, Iwate, Japan. Electronic address: mashiba@iwate-med.ac.jp.
Masahiko
M
Shibazaki
Department of Tumor Biology, Institute of Biomedical Science, Iwate Medical University, Iwate, Japan.
Shuya
S
Kasai
Department of Tumor Biology, Institute of Biomedical Science, Iwate Medical University, Iwate, Japan.
Shinji
S
Yasuhira
Department of Tumor Biology, Institute of Biomedical Science, Iwate Medical University, Iwate, Japan; Department of Dermatology, Iwate Medical University, Iwate, Japan.
Ayano
A
Watanabe
Department of Tumor Biology, Institute of Biomedical Science, Iwate Medical University, Iwate, Japan; Department of Dermatology, Iwate Medical University, Iwate, Japan.
Tsuyoshi
T
Inoue
Department of Tumor Biology, Institute of Biomedical Science, Iwate Medical University, Iwate, Japan; Department of Dermatology, Iwate Medical University, Iwate, Japan.
Yuich
Y
Kageshita
Department of Dermatology, Iwate Medical University, Iwate, Japan.
Kanako
K
Tsunoda
Department of Dermatology, Iwate Medical University, Iwate, Japan.
Kazuhiro
K
Takahashi
Department of Dermatology, Iwate Medical University, Iwate, Japan.
Toshihide
T
Akasaka
Department of Pathology, School of Medicine, Iwate Medical University, Iwate, Japan.
Tomoyuki
T
Masuda
Department of Tumor Biology, Institute of Biomedical Science, Iwate Medical University, Iwate, Japan.
Chihaya
C
Maesawa
D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D016368:Frameshift Mutation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D000072019:Kelch-Like ECH-Associated Protein 1; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism; D020125:Mutation, Missense; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism
D047908:Intracellular Signaling Peptides and Proteins; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human