Vulvar pseudoepitheliomatous hyperplasia associated with herpes simplex virus type II mimicking cancer in an immunocompromised patient.
We report an exaggerated dermatological inflammatory condition in an immunocompromised patient. The patient was a 51-year-old woman who had HIV infection and a history of cervical cancer. Three years after highly active antiretroviral therapy with an improved immune status, and 2 years after remission of cervical cancer, she developed verrucous perineal masses. Provisional diagnosis was recurrent cervical cancer or primary vulvar cancer. Pathological features revealed pseudoepitheliomatous hyperplasia associated with herpes viral infection. After minimal response to systemic oral antiviral drugs and topical imiquimod, she had clinical resolution with the addition of systemic oral corticosteroid.
Department of Obstetrics and Gynecology, University of Bangkok Metropolis, Bangkok, Thailand.
Siriwan
S
Tangjitgamol
Kongsak
K
Loharamtaweethong
Thaovalai
T
Thawaramara
Saranya
S
Chanpanitkitchot
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections / Q000150:complications; D006558:Herpes Genitalis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D018258:Herpesvirus 2, Human / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D006965:Hyperplasia; D016867:Immunocompromised Host / Q000187:drug effects; D008875:Middle Aged; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000150:complications; D014844:Vulva / Q000187:drug effects / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D014845:Vulvar Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D014846:Vulvar Neoplasms / Q000175:diagnosis
D000305:Adrenal Cortex Hormones; D000998:Antiviral Agents
herpes simplex virus; immunocompromised; vulvar pseudoepitheliomatous hyperplasia