Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains.
The copper metallochaperone Atx1 and the N-terminal metal-binding domain of a copper-transporting ATP-ase can form tight Zn(II)-mediated hetero-complexes in both cyanobacteria and humans. Copper and zinc homeostasis could be linked by metal binding to these CXXC-containing proteins.
Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Adriana
A
Badarau
Arnaud
A
Baslé
Susan J
SJ
Firbank
Christopher
C
Dennison
D000251:Adenosine Triphosphatases / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D000079922:Copper Transport Proteins; D018360:Crystallography, X-Ray; D006706:Homeostasis; D006801:Humans; D056511:Metallochaperones / Q000737:chemistry*; D008958:Models, Molecular; D018832:Molecular Chaperones; D011485:Protein Binding; D017433:Protein Structure, Secondary; D015032:Zinc / Q000737:chemistry*
C474500:ATOX1 protein, human; D056831:Coordination Complexes; D000079922:Copper Transport Proteins; D056511:Metallochaperones; D018832:Molecular Chaperones; D003300:Copper; D000251:Adenosine Triphosphatases; D015032:Zinc