Improved field free line magnetic particle imaging using saddle coils.
Magnetic particle imaging (MPI) is a novel tracer-based imaging method detecting the distribution of superparamagnetic iron oxide (SPIO) nanoparticles in vivo in three dimensions and in real time. Conventionally, MPI uses the signal emitted by SPIO tracer material located at a field free point (FFP). To increase the sensitivity of MPI, however, an alternative encoding scheme collecting the particle signal along a field free line (FFL) was proposed. To provide the magnetic fields needed for line imaging in MPI, a very efficient scanner setup regarding electrical power consumption is needed. At the same time, the scanner needs to provide a high magnetic field homogeneity along the FFL as well as parallel to its alignment to prevent the appearance of artifacts, using efficient radon-based reconstruction methods arising for a line encoding scheme. This work presents a dynamic FFL scanner setup for MPI that outperforms all previously presented setups in electrical power consumption as well as magnetic field quality.
Marlitt
M
Erbe
Timo F
TF
Sattel
Thorsten M
TM
Buzug
D003287:Contrast Media; D011211:Electric Power Supplies; D004735:Energy Transfer; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D008280:Magnetics / Q000295:instrumentation*; D058185:Magnetite Nanoparticles; D057054:Molecular Imaging / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D003287:Contrast Media; D058185:Magnetite Nanoparticles