[Comparative study on effect of crude and different processed products of epimedium on pharmacokinetics characteristics in mice].
To study different impacts of crude epimedium and extracts from different processed epimedium on pharmacokinetic characteristic parameters in mice. To explore the rationality of its processed products, mice were orally administered with crude epimedium and extracting solutions from heated epimedium and processed epimedium. With increased SOD value as an indicator, the relationship between time and equivalent body dose was obtained by using the pharmacological effect method. DAS 2.0 software was adopted to compare their pharmacokinetic parameters. The results showed significant differences in such pharmacokinetic parameters as Cmax and AUC of processed epimedium, heated epimedium and crude epimedium, namely processed epimedium > heated epimedium > crude epimedium. We could come to the conclusion that heated epimedium showed increased bioavailability, while epimedium processed with sheep oil could further promote in vivo absorption.
Key Laboratory of Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, China. cuili2008516@126.com
Li
L
Cui
E
E
Sun
Qian
Q
Qian
Hong-Wei
HW
Fan
Jian-Jun
JJ
Zou
Xiao-Bin
XB
Jia
D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics*; D034181:Epimedium / Q000737:chemistry*; D008297:Male; D051379:Mice
D004365:Drugs, Chinese Herbal