Novel role of microRNAs in prostate cancer.
OBJECTIVE
To discuss the novel biomarkers of microRNAs in prostate cancer.


METHODS
The literatures about microRNAs and prostate cancer cited in this review were obtained mainly from Pubmed published in English from 2004 to 2012.


METHODS
Original articles regarding the novel role of microRNAs in prostate cancer were selected.


RESULTS
MicroRNAs play an important role in prostate cancer such as cell differentiation, proliferation, apoptosis, and invasion. Especially microRNAs correlate with prostate cancer cell epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), drug sensitivity, cancer microenvironment, energy metabolism, androgen independence transformation, and diagnosis prediction.


CONCLUSIONS
MicroRNAs are involved in various aspects of prostate cancer biology. The role of microRNA in the initiation and development of prostate cancer deserves further study.
Department of Urology, First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
Jun-jie
JJ
Yu
Shu-jie
SJ
Xia
D015415:Biomarkers / Q000032:analysis; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
D015415:Biomarkers; D035683:MicroRNAs