Palladium/copper-catalyzed oxidative C-H alkenylation/N-dealkylative carbonylation of tertiary anilines.
C-H/C-N activation: The first palladium/copper-catalyzed aerobic oxidative C-H alkenylation/N-dealkylative carbonylation of tertiary anilines has been developed. Various functional groups were tolerated and acrylic ester could also be suitable substrates. This transformation provided efficient and straightforward synthesis of biologically active 3-methyleneindolin-2-one derivatives from cheap and simple substrates.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China).
Renyi
R
Shi
Lijun
L
Lu
Hua
H
Zhang
Borui
B
Chen
Yuchen
Y
Sha
Chao
C
Liu
Aiwen
A
Lei
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D000477:Alkylating Agents / Q000737:chemistry; D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000475:Alkenes; D000477:Alkylating Agents; D000814:Aniline Compounds; D007211:Indoles; D009942:Organometallic Compounds; D010165:Palladium; D003300:Copper
CH activation; CN bond activation; aminocarbonylation; indolin-2-ones; palladium