A N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide (Ds-DAB) based fluorescent chemosensor for peroxynitrite.
A dansyl derivative (Ds-DAB) was prepared and used as a fluorescent probe for peroxynitrite (ONOO(-)) detection. The results showed that the addition of peroxynitrite to the aqueous solution of Ds-DAB would result in obvious fluorescence enhancement. This probe is highly specific for peroxynitrite in aqueous solution, avoiding interference from other reactive oxygen species (ROS) and nitrogen species (RNS). The advantages of high selectivity, fast reaction rate, and peroxynitrite bioimaging render Ds-DAB suitable for peroxynitrite detection.
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan.
Ku-Kuei
KK
Lin
Shou-Cheng
SC
Wu
Kuang-Mei
KM
Hsu
Chen-Hsiung
CH
Hung
Wen-Feng
WF
Liaw
Yun-Ming
YM
Wang
D003619:Dansyl Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D009282:Naphthalenesulfonates / Q000138:chemical synthesis* / Q000737:chemistry; D030421:Peroxynitrous Acid / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D003619:Dansyl Compounds; D005456:Fluorescent Dyes; C585758:N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide; D009282:Naphthalenesulfonates; D030421:Peroxynitrous Acid