Bioengineering heart tissue for in vitro testing.
A classical paradigm of tissue engineering is to grow tissues for implantation by using human stem cells in conjunction with biomaterial scaffolds (templates for tissue formation) and bioreactors (culture systems providing environmental control). A reverse paradigm is now emerging through microphysiological platforms for preclinical testing of drugs and modeling of disease that contain large numbers of very small human tissues. We discuss the biomimetic approach as a common underlying principle and some of the specifics related to the design and utilization of platforms with heart micro-tissues for high-throughput screening in vitro.
Columbia University, Department of Biomedical Engineering, 622 West 168th Street, VC12-234, New York, NY 10032, USA.
Elisa
E
Cimetta
Amandine
A
Godier-Furnémont
Gordana
G
Vunjak-Novakovic
D000818:Animals; D001672:Biocompatible Materials; D032701:Biomimetics / Q000379:methods*; D019149:Bioreactors; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006331:Heart Diseases / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D057166:High-Throughput Screening Assays / Q000379:methods; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D001672:Biocompatible Materials