Interleukin-27 rs153109 polymorphism and the risk for immune thrombocytopenia.
The aim of the present study was to investigate the association of single nucleotide polymorphisms (SNP) of the interleukin-27 (IL-27) genes with the risk for immune thrombocytopenia (ITP). In this case-control study, the genotyping of IL-27 rs153109 polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In ITP patients, the frequencies of GG, GA and AA genotypes, and G and A alleles were 9.7%, 58.5%, 31.8%, 38.9% and 61.1%, respectively. There was no significant difference in genotype and alleles distribution between the ITP patient and the healthy controls (p = 0.68 and 0.80, respectively). Similar results were found between the two groups when stratified by the age and disease course including non-chronic adult, chronic adult, non-chronic childhood, and chronic childhood. In conclusion, the IL-27 polymorphism may not be involved in susceptibility to ITP in a Chinese population.
Department of Hematology and Oncology, TianJin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy , Tianjin , PR China .
Haifeng
H
Zhao
Yizhuo
Y
Zhang
Feng
F
Xue
Jianfen
J
Xu
Zhi
Z
Fang
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D064094:Interleukin-27 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics*; D055815:Young Adult
D064094:Interleukin-27