Comparison of operative risks associated with radical hysterectomy in pregnant and nonpregnant women.
OBJECTIVE
To compare the operative data and complications of radical hysterectomy performed on pregnant women versus nonpregnant women.


METHODS
Following institutional review board approval, we reviewed our surgical databases to identify pregnant women who had undergone a radical hysterectomy for cervical carcinoma from 1992-2005 (n = 7). A nonpregnant control group (n = 35) of women undergoing radical hysterectomy during the study interval were identified and matched for age, year of surgery, and surgeon. Pertinent operative and outcome data were abstracted and compared.


RESULTS
Of the 7 women who had undergone a radical hysterectomy during pregnancy, 4 had a cesarean radical hysterectomy at a mean gestational age of 35.4 weeks (range, 32.3-38 weeks) and 3 had a radical hysterectomy with a previable fetus in situ at a mean gestational age of 14.2 weeks. Demographics were similar between groups. Transfusion rates were significantly higher among pregnant women (57%) as compared to nonpregnant controls (9%) (p = 0.0009). The overall incidence of operative complications was similar between the pregnant women (43%) and nonpregnant controls (40%) (p = NS).


CONCLUSIONS
Radical hysterectomy performed in pregnant women was associated with higher blood loss and increased need for transfusion as compared to nonpregnant controls. No differences were observed in regards to other operative surgical complications between the two groups.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama School of Medicine, 1700 6th Avenue South, Room 10250, Birmingham, AL 35249, USA. trey_leath@yahoo.com
Charles A
CA
Leath
Kerri S
KS
Bevis
T Michael
TM
Numnum
Patrick S
PS
Ramsey
Warner K
WK
Huh
J Michael
JM
Straughn
D000328:Adult; D016063:Blood Loss, Surgical / Q000706:statistics & numerical data; D001803:Blood Transfusion; D002585:Cesarean Section; D005260:Female; D005865:Gestational Age; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007431:Intraoperative Complications / Q000453:epidemiology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000601:surgery*; D012307:Risk Factors; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000401:mortality / Q000601:surgery*