Stereoselective metal-free catalytic synthesis of chiral trifluoromethyl aryl and alkyl amines.
The enantioselective organocatalytic reduction of trifluoromethyl aryl and alkyl ketoimines afforded the corresponding fluorinated amines with high chemical and stereochemical efficiency. The Lewis base catalyzed reaction with trichlorosilane led to chiral products with a trifluoromethyl group directly linked to the newly generated stereocenter typically in >90% yield and up to 98% e.e.
Dipartimento di Chimica, Università di Milano, Via Golgi 19, 20133, Milano, Italy. maurizio.benaglia@unimi.it.
Andrea
A
Genoni
Maurizio
M
Benaglia
Elisabetta
E
Massolo
Sergio
S
Rossi