Nuclear topology, epigenetics, and keratinocyte differentiation.
Recent progress in epigenetics reveals dynamic chromatin interactions in the nucleus during development, regeneration, reprogramming, and in disease. Higher-order chromatin organization is manifested as changes in the topological distribution of eu-/heterochromatin and in nuclear morphology. We are now able to gain new knowledge about these changes at the genomic level.
National Cheng Kung University School of Medicine, Tainan, Taiwan. z10110045@email.ncku.edu.tw
Michael W
MW
Hughes
Wange
W
Lu
Cheng-Ming
CM
Chuong
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002466:Cell Nucleolus / Q000502:physiology*; D002467:Cell Nucleus / Q000502:physiology*; D000078404:Epidermal Cells; D015603:Keratinocytes / Q000166:cytology*; D008954:Models, Biological