Dexmedetomidine-induced atrioventricular block followed by cardiac arrest during atrial pacing: a case report and review of the literature.
Sinus bradycardia is a well-known consequence of stimulation of presynaptic α2 adrenergic receptors due the adminstration of dexmedetomidine. One of the most serious adverse effects of dexmedetomidine is cardiac arrest. Some cases demonstrating such an arrest due to the indiscriminate use of this drug were recently reported. We continuously administered dexmedetomidine to a 56-year-old male patient at a rate of 0.3 μg/kg/h (lower than the recommended dose) without initial dosing for sedation in an intensive care unit. The patient had undergone open cardiac surgery and atrial pacing was maintained at a fixed rate, 90/min. The PQ interval in electrocardiography gradually prolonged during the infusion; finally, complete atrioventricular block and subsequent cardiac arrest occurred. Immediate cardiopulmonary resuscitation was carried out, including re-intubation, and recovery of spontaneous circulation was attained 15 min after the event. The patient was discharged from hospital on the 25th postoperative day without any neurological complications.
Department of Anesthesia, Japanese Red Cross Hamamatsu Hospital, Hamamatsu, Shizuoka, 4348533, Japan.
Kotaro
K
Takata
Yushi U
YU
Adachi
Katsumi
K
Suzuki
Yukako
Y
Obata
Shigehito
S
Sato
Kimitoshi
K
Nishiwaki
D054537:Atrioventricular Block / Q000139:chemically induced*; D001919:Bradycardia / Q000139:chemically induced; D002304:Cardiac Pacing, Artificial; D006348:Cardiac Surgical Procedures / Q000379:methods; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
D020927:Dexmedetomidine