Imidacloprid does not induce Cyp genes involved in insecticide resistance of a mutant Drosophila melanogaster line.
Certain xenobiotics have the capacity to induce the expression of genes involved in various biological phenomena, including insecticide resistance. The induction potential of different chemicals, among them different insecticides, has been documented for a number of insect species. In this study, we have analyzed the induction potential of Imidacloprid, a widely used member of the neonicotinoid insecticide family. Genes Cyp6g1 and Cyp6a2, known to be involved in the resistance of mutant Drosophila melanogaster line MiT[W⁻]3R2 to Imidacloprid and DDT were included in the analyzed sample. We find that Imidacloprid does not induce expression of the analyzed genes.
Institute for Biological Research, University of Belgrade, 142 Despot Stefan Blvd., 11060 Belgrade, Serbia; Medical School, University of Crete, P.O. Box 2208, 71003 Heraklion, Crete, Greece. Electronic address: pedja@evolbio.mpg.de.
Predrag
P
Kalajdzic
Maria
M
Markaki
Stefan
S
Oehler
Charalambos
C
Savakis
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D000072472:Cytochrome P450 Family 6; D003634:DDT / Q000633:toxicity; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics*; D005786:Gene Expression Regulation; D007093:Imidazoles / Q000633:toxicity*; D007305:Insecticide Resistance; D007306:Insecticides / Q000633:toxicity; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000633:toxicity*; D015262:Xenobiotics / Q000633:toxicity
D029721:Drosophila Proteins; D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; D015262:Xenobiotics; C082359:imidacloprid; D003577:Cytochrome P-450 Enzyme System; D003634:DDT; C446928:Cyp6g1 protein, Drosophila; C109499:Cyp6a2 protein, Drosophila; D000072472:Cytochrome P450 Family 6
Cytochrome P450; D. melanogaster; Imidacloprid; Induction