[Special influence of molecular imprinting technology on traditional Chinese medicine theories].
OBJECTIVE
To investigate the influence of molecular imprinting phenomena of traditional Chinese medicines (TCMs) on basic theories of TCMs according to current situations of molecular imprinting technology and experimental studies.


METHODS
Fundamental principles of molecular imprinting theory were followed to analyze the material basis for TCM molecules to generate the imprinting phenomena, in order to find other material basis with more direct efficacy in line with the requirements of basic theories and modernization of TCMs.


RESULTS
Compared with single-component structures, TCMs and their compound components could create super-molecular compounds through complexation, composition, chelation, inclusion, neutralization, self-assembly and chemical reaction. The material basis of TCMs was super-molecular compounds including single ingredients, and there was an inter-molecule imprinting phenomenon. Therefore, special attention should be paid to inter-super-molecule imprinting actions in studies on TCM property, quality control, processing, drug preparation and pharmacology. The compatibility of TCM compounds could significantly change the action.


CONCLUSIONS
The material basis of TCMs is super-molecular compounds based on single molecular groups. Super-molecules and molecular groups act rules, which is another difference between TCM compounds and single molecular drugs.
Department of Pharmaceutics, Hunan University of Tradition Chinese Medicine, Changsha 410208, China. 283223074@qq.com
Zan-Shao
ZS
Xia
Fu-Yuan
FY
He
Kai-Wen
KW
Deng
Wen-Long
WL
Liu
Ji-Lian
JL
Shi
Yu
Y
Tang
D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D008516:Medicine, Chinese Traditional; D054802:Molecular Imprinting
D004365:Drugs, Chinese Herbal