A randomized study of simultaneous hCG administration with intrauterine insemination in stimulated cycles.
OBJECTIVE
To compare the clinical pregnancy rates between intrauterine insemination (IUI) simultaneously or 34-36 h following hCG injection in gonadotropin-stimulated IUI cycles.


METHODS
Randomized, prospective, controlled, study conducted in a university infertility clinic. Of 923 infertile couples, 220 couples with unexplained infertility or mild male factor infertility were included to the study. Before ovarian stimulation patients were randomized into two groups: IUI at 34-36 h after hCG injection (group I) (n=106) and IUI simultaneously with hCG administration (group II) (n=98). The primary outcome was clinical pregnancy rates.


RESULTS
There was no significant difference between the groups according to baseline patient and cycle characteristics. Clinical pregnancy rates were 9.4% and 12.2% in group I and group II, respectively (p=0.523). Although group II had better outcomes there was no statistically significant difference in clinical pregnancy rates between the different timing methods: IUI simultaneously with hCG versus IUI at 34-36 h after hCG (odds ratio (OR)=1.35, 95% CI 0.53-3.42).


CONCLUSIONS
There is no difference in simultaneous use of hCG injection compared to cycles in which IUI is performed after 34-36 h following hCG injection. Prospective randomized trials with larger sample sizes or meta-analyses are required.
Eskisehir Osmangazi University School of Medicine, Department of Obstetrics and Gynecology, Turkey. Electronic address: aydin.yunus@yahoo.com.
Yunus
Y
Aydin
Hikmet
H
Hassa
Tufan
T
Oge
V Yavuz
VY
Tokgoz
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D012102:Reproductive Control Agents / Q000008:administration & dosage*; D013997:Time Factors
D006063:Chorionic Gonadotropin; D012102:Reproductive Control Agents
Clinical pregnancy; Human chorionic gonadotropin hormone; Intrauterine insemination