Hybrid PET/MR imaging of tumors using an oleanolic acid-conjugated nanoparticle.
Research into multifunctional nanoparticles is focused on creating an agent for use in an all-in-one multimodal imaging system that includes diagnostic imaging, drug delivery, and therapeutic monitoring. We designed a new dual-modality tumor-targeting agent with a new tumor-targeting molecule, oleanolic acid (OA), which is derived from a natural compound and coupled with a macrocyclic chelating agent such as 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), iron oxide nanoparticles (IONP), and radiolabeling components such as (68)Ga for dual-modality positron emission tomography (PET)/magnetic resonance imaging (MRI). We attempted to obtain fusion PET/MR images with the (68)Ga-NOTA-OA-IONP hybrid tumor-targeting imaging agent using colon cancer (HT-29) xenograft mice models. The HT-29 cancer cells showed high uptake of (68)Ga-NOTA-OA-IONP, which also had an inhibitory effect on the cells. Moreover, we obtained PET and MRI tumor images as well as fusion PET/MRI images of the tumors using (68)Ga-NOTA-OA-IONP. Therefore, the dual-modality cancer-targeting radiolabeled nanoparticle reported here is a potent imaging agent that is suitable for PET, MRI, and PET/MRI-based diagnosis of tumors; it also has the advantage of not only detecting tumor functionality, but also simultaneously aiding in tumor resolution.
Center of Magnetic Resonance Research, Korea Basic Science Institute (KBSI), Chungbuk 363-883, Republic of Korea.
Sung-min
SM
Kim
Min Kyung
MK
Chae
Min Su
MS
Yim
Il Ha
IH
Jeong
Janggeun
J
Cho
Chulhyun
C
Lee
Eun Kyoung
EK
Ryu
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000175:diagnosis; D005290:Ferric Compounds / Q000737:chemistry*; D019073:HT29 Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009828:Oleanolic Acid / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*
D005290:Ferric Compounds; C000499:ferric oxide; D009828:Oleanolic Acid
Colon cancer; Diagnosis; Iron oxide nanoparticle; Oleanolic acid; PET/MRI