Medicinal plants of Chile: evaluation of their anti-Trypanosoma cruzi activity.
The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 microg/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T. cruzi with IC50 values of 27.9 and 25.1 microM, respectively.
Department of Chemistry, Faculty of Science, University of Chile, Santiago, Chile. omunoz@uchile.cl
Orlando M
OM
Muñoz
Juan D
JD
Maya
Jorge
J
Ferreira
Philippe
P
Christen
José
J
San Martin
Rodrigo
R
López-Muñoz
Antonio
A
Morello
Ulrike
U
Kemmerling
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002677:Chile; D002522:Chlorocebus aethiops; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014349:Trypanosoma cruzi / Q000187:drug effects*; D014709:Vero Cells
D000981:Antiprotozoal Agents; D010936:Plant Extracts