Lessons learned from gene expression profiling of cutaneous T-cell lymphoma.
Gene expression studies of cutaneous T-cell lymphoma (CTCL) span a decade, yet the pathogenesis is poorly understood and diagnosis remains a challenge. This review examines the varied approaches to gene expression analysis of CTCL, with emphasis on cell populations, control selection and expression data collection. Despite discordant results, several dysregulated genes have been identified across multiple studies, including PLS3, KIR3DL2, TWIST1 and STAT4. Here, we provide an overview of the most consistently expressed genes across different studies and bring them together through common pathways biologically relevant to CTCL. Four pathways - evasion of activation-induced cell death, T helper 2 lymphocyte differentiation, transforming growth factor-β receptor expression, and tumour necrosis factor receptor ligands - appear to encompass the most frequently affected genes, hypothetically providing insight into the disease pathogenesis.
Department of Dermatology, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA, 15213, U.S.A.
B O
BO
Dulmage
L J
LJ
Geskin
D016923:Cell Death / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D020869:Gene Expression Profiling; D052138:Genes, Neoplasm / Q000235:genetics*; D018740:Genetic Heterogeneity; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics* / Q000276:immunology; D009363:Neoplasm Proteins / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D009363:Neoplasm Proteins; D022661:RNA, Untranslated; D018125:Receptors, Transforming Growth Factor beta; D018124:Receptors, Tumor Necrosis Factor