Short-term evaluation of autologous transplantation of bone marrow-derived mesenchymal stem cells in patients with cirrhosis: Egyptian study.
BACKGROUND
Stem cell-based therapy has received attention as a possible alternative to organ transplantation. The aim of this study was to assess the safety and efficacy of autologous transplantation of bone marrow (BM)-derived stromal cells in post-HCV liver cirrhosis patients.


METHODS
10 × 10(6) of isolated human bone marrow (HBM)-stromal cells in 10 mL normal saline were injected in the spleen of 20 patients with end-stage liver cirrhosis guided by the ultrasonography, and then patients were followed up on monthly basis for six months.


RESULTS
A statistically significant decrease was detected in the total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) (p-value<0.01), prothrombin time (PT), and international normalized ratio (INR) levels (p-value<0.05), while a statistically significant increase in the albumin and PC (p-value<0.05) after follow-up.


CONCLUSIONS
This study suggested the safety, feasibility, and efficacy of the intrasplenic injection of autologous BM stromal cells in improving liver function in Egyptian patients with cirrhosis.
Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mona A
MA
Amin
Dina
D
Sabry
Laila A
LA
Rashed
Wael M
WM
Aref
Mohamed Ahmed
MA
el-Ghobary
Marwa Salah
MS
Farhan
Hany Ahmed
HA
Fouad
Youssef Abdel-Aziz
YA
Youssef
D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001853:Bone Marrow / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism / Q000628:therapy*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D017154:Stromal Cells / Q000637:transplantation*; D014182:Transplantation, Autologous
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Egypt; human; intrasplenic injection - liver cirrhosis patients; mesenchymal stem cells