Is tumor necrosis factor-α friend or foe for chronic heart failure?
Although detrimental effects of tumor necrosis factor-α (TNF-α) have been reported in failing myocardium, clinical trials using TNF-α antagonists did not show the benefit of TNF-α inhibition in patients with chronic heart failure (CHF). The double-edged effects of TNF-α/Toll-like receptors (TLRs)-related proinflammatory cytokines and downstream signal transduction, nuclear factor (NF)-κB activation on failing myocardium are discussed.
Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. hori-ma@mc.pref.osaka.jp
Masatsugu
M
Hori
Osamu
O
Yamaguchi
D000818:Animals; D000911:Antibodies, Monoclonal / Q000266:history / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy / Q000266:history* / Q000378:metabolism; D049673:History, 20th Century; D051379:Mice; D008822:Mice, Transgenic; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha