Utility of maternal 6-thioguanine nucleotide levels in predicting neonatal pancytopenia.
An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 10(8) red blood cells, respectively. Maternal 6TGN levels could be useful in predicting neonatal pancytopenia.
Department of Neonatology, National Hospital Organization, Okayama Medical Center, Okayama, Japan.
Hidehiko
H
Maruyama
Katsuhiko
K
Tada
Takuzo
T
Fujiwara
Kosuke
K
Ota
Misao
M
Kageyama
6-thioguanine nucleotides; azathioprine; pancytopenia