Sunitinib-induced reversible purpuric rash in a patient with gastrointestinal stromal tumor.
Sunitinib which is used in the treatment of kidney cancer, gastrointestinal stromal tumor, and advanced pancreatic neuroendocrine tumor is a multi-targeted tyrosine kinase inhibitor. Although sunitinib is associated with some side effects, it is generally well tolerated. In the present case, the diagnosis of gastrointestinal stromal tumor was four years ago. The patient had multiple liver metastases at the time of diagnosis. Sunitinib was initiated with a dose of 50 mg daily for four weeks and two weeks off, because of resistance of imatinib. The patient was admitted to the hospital with purpuric rash on her arms and body in the eighth week of treatment. No other disorders or drugs which may cause purpuric rash were detected in the patient. Purpuric rash disappeared two weeks after sunitinib discontinuation without any further intervention.
Department of Medical Oncology, Acıbadem Kayseri Hospital, Kayseri, Turkey doktorhasanmutlu@gmail.com.
Hasan
H
Mutlu
Department of Internal Medicine, Acıbadem University School of Medicine, Istanbul, Turkey.
Abdullah
A
Büyükçelik
Department of Radiation Oncology, Mersin Government Hospital, Mersin, Turkey.
Zeki
Z
Akça
Department of Medical Oncology, Acıbadem Kayseri Hospital, Kayseri, Turkey.
Nilgün
N
Kaya
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects*; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D011758:Pyrroles / Q000008:administration & dosage / Q000009:adverse effects*; D000077210:Sunitinib
D000970:Antineoplastic Agents; D007211:Indoles; D047428:Protein Kinase Inhibitors; D011758:Pyrroles; D000068877:Imatinib Mesylate; D000077210:Sunitinib
Sunitinib; adverse event; gastrointestinal stromal tumor; vasculitis