Lack of association between MPC2 variants and schizophrenia in a replication study of Han Chinese.
Schizophrenia (SCZ) is a common, complex and severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified a single-nucleotide polymorphism (SNP, rs10489202) in the mitochondrial pyruvate carrier 2 gene (MPC2, also known as BRP44) as a possible susceptibility locus for schizophrenia. Hoping to validate this finding, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls, using the LDR-PCR method to genotype polymorphisms (rs10489202 and a TagSNP rs203861) in the MPC2 gene. However, we found no significant difference (P>0.05) in either allele or genotype frequency in the SNPs between patients and controls. These results did not support the previous finding suggesting the further study by using a large-scale association analysis in the future should be warranted in Han Chinese populations.
Wuxi Mental Health Center, Wuxi 214151, Jiangsu Province, China.
Chunhui
C
Jin
Yunbiao
Y
Zhang
Jidong
J
Wang
Zhenhe
Z
Zhou
Weiwei
W
Sha
Mingzhong
M
Wang
Fuquan
F
Zhang
Jijiang
J
Li
Jianfeng
J
Li
Shui
S
Yu
Shuguang
S
Qi
Jianmin
J
Yuan
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
D024101:Mitochondrial Proteins
Allele; Han Chinese; Mitochondrial pyruvate carrier 2; Schizophrenia; Single nucleotide polymorphism