Concise review: combining human leukocyte antigen G and mesenchymal stem cells for immunosuppressant biotherapy.
Both human leukocyte antigen G (HLA-G) and multipotential mesenchymal stem/stromal cells (MSCs) exhibit immunomodulatory functions. In allogeneic tranplantation, the risks of acute and chronic rejection are still high despite improvement in immunosuppressive treatments, and the induction of a state of tolerance to alloantigens is not achieved. Immunomodulatory properties of MSCs and HLA-G in human allogeneic tranplantation to induce tolerance appears attractive and promising. Interestingly, we and others have demonstrated that MSCs can express HLA-G. In this review, we focus on the expression of HLA-G by MSCs and discuss how to ensure and improve the immunomodulatory properties of MSCs by selectively targeting MSCs expressing HLA-G (MSCs(HLA-G+)). We also discuss the possible uses of MSCs(HLA-G+) for therapeutic purposes, notably, to overcome acute and chronic immune rejection in solid-organ allogeneic transplantation in humans. Since MSCs are phenotypically and functionally heterogeneous, it is of primary interest to have specific markers ensuring that they have strong immunosuppressive potential and HLA-G may be a valuable candidate.
CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, Paris, France.
Abderrahim
A
Naji
Nathalie
N
Rouas-Freiss
Antoine
A
Durrbach
Edgardo D
ED
Carosella
Luc
L
Sensébé
Frédéric
F
Deschaseaux
D000818:Animals; D001691:Biological Therapy / Q000379:methods*; D059951:HLA-G Antigens / Q000096:biosynthesis / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000276:immunology; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000276:immunology* / Q000378:metabolism; D014181:Transplantation Immunology; D014184:Transplantation, Homologous / Q000379:methods
D059951:HLA-G Antigens; D007166:Immunosuppressive Agents
Immunosuppression, HLA-G; Mesenchymal stem cells; Transplantation tolerance