Cytotoxic ent-kaurane diterpenoids from Isodon nervosus.
Four new ent-kaurane diterpenoids, rabdonervosins G-J (1-4, resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC-9/ZD cell lines with IC50 values of 2.36 and 6.07 μM, respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC50 values of 8.64 and 9.77 μM, respectively.
Department of Phytochemistry, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China. gaoyouheng@gzhtcm.edu.ch
You-Heng
YH
Gao
Zhi-Xiong
ZX
Wei
Yi
Y
Cheng
Teng-Hua
TH
Wang
Lin
L
Ni
Xiao-Hong
XH
Zhou
Li-Yuan
LY
Zhang
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity*
D000970:Antineoplastic Agents; D045786:Diterpenes, Kaurane; D010936:Plant Extracts
Cytotoxic activity; Isodon nervosus; Rabdonervosins G - J; Terpenoids; ent-Kaurane diterpenoids