SAA1 genetic polymorphisms are associated with plasma glucose concentration in non-diabetic subjects.
BACKGROUND
Serum amyloid A (SAA) was reported to be associated with insulin resistance and type-2 diabetes. The present study aimed to investigate the association of SAA genetic polymorphisms with plasma glucose levels in non-diabetic subjects.


METHODS
All participants (n=1220) were selected from subjects participating in the Cardiovascular Risk Survey (CRS) study. Five single-nucleotide polymorphisms (SNPs) (rs2229338, rs12218, rs4638289, rs7131332 and rs11603089) of SAA gene were genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis.


RESULTS
In the present study, we found rs2229338, rs4638289 and rs12218 were significantly associated with plasma glucose levels in a dominate model, recessive model or additive model before and after multivariate adjustment (all p<0.05). These associations were not found in rs7131332 and rs11603089 before and after adjustment of key co-variants.


CONCLUSIONS
The genetic polymorphisms of SAA1 were associated with plasma glucose levels in non-diabetic subjects.
Xiang
X
Xie
Yi-Tong
YT
Ma
Yi-Ning
YN
Yang
Xiao-Mei
XM
Li
Ying-Ying
YY
Zheng
Zhen-Yan
ZY
Fu
Xiang
X
Ma
Fen
F
Liu
Ying
Y
Huang
Bang-Dang
BD
Chen
D001786:Blood Glucose / Q000032:analysis*; D002681:China; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D000685:Serum Amyloid A Protein / Q000235:genetics*
D001786:Blood Glucose; C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein