Notch and Wnt signaling in the emergence of hematopoietic stem cells.
Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels.
Program in Cancer Research, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain. Electronic address: abigas@imim.es.
Anna
A
Bigas
Jordi
J
Guiu
Leonor
L
Gama-Norton
D000818:Animals; D001011:Aorta / Q000196:embryology / Q000378:metabolism; D047108:Embryonic Development; D006066:Gonads / Q000196:embryology / Q000378:metabolism; D006410:Hematopoiesis / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D008650:Mesonephros / Q000196:embryology / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*
D051880:Receptors, Notch; D051153:Wnt Proteins
AGM; Delta-like ligand; Dll; EGF; Embryonic hematopoiesis; FL; Frizzled; Fzd; GOF; HSC; Hematopoiesis; Hes; Hrt; Jag; Jagged ligand; LDL-receptor related proteins; LEF/TCF; LOF; LRP; NICD; Notch; Notch intracellular domain; PB; RBPj; Wnt; YS; aorta-gonad-mesonephros; epidermal growth factor; fetal liver; gain of function; hairy/enhancer-of-split; hairy/enhancer-of-split related transcriptional factor; hematopoietic stem cell; loss of function; lymphoid enhancer factor T-cell factor; peripheral blood; recombination signal binding protein for immunoglobulin kappa J region; yolk sac