The sequence of events in diffuse large B-cell lymphoma.
In this issue of Blood, Morin et al report their findings on complete genome sequence analysis of primary diffuse large B-cell lymphoma (DLBCL) primary tumors and cell lines and reveal novel somatic point mutations, rearrangements, and fusions. Importantly, they also demonstrate the temporal acquisition of mutations, providing insight into the evolution of mutations occurring in DLBCL.
Queen Mary, University of London, UK.
John G
JG
Gribben
D014408:Biomarkers, Tumor / Q000737:chemistry* / Q000235:genetics*; D056915:DNA Copy Number Variations / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D009154:Mutation / Q000235:genetics*
D014408:Biomarkers, Tumor