Serum m 30 levels reflects ulcerative colitis activity.
BACKGROUND
Apoptosis plays a role in epithelial and mucosal injury, which is 1 of the mechanisms in the pathogenesis of ulcerative colitis. Apoptotic cells increase as a result of injured mucosa in ulcerative colitis and serum M 30 levels increase in epithelial cell apoptosis. In this study, we aimed to evaluate the relation between M 30 serum levels and ulcerative colitis activity.


METHODS
Eighty patients with ulcerative colitis and 40 healthy controls were enrolled into the study. The patient group consisted of 31 extensive colitis, 30 left-sided colitis, and 19 proctitis. The activity of ulcerative colitis was determined with clinical and endoscopic findings. Serum M 30 levels, acute phase reactants, and biochemical tests were analyzed in all subjects.


RESULTS
Serum M 30 levels in patients with active ulcerative colitis were significantly higher when compared with the healthy controls (165.6 ± 60.6 and 129.6 ± 37.4; P = 0.003). Serum M 30 levels in active left-sided colitis patients was significantly higher when compared with patients in remission phase (180.6 ± 58.5, 141.5 ± 35.4; P = 0.044). When we exclude patients with ulcerative proctitis, M 30 levels in active ulcerative colitis patients were significantly higher than that the patients in remission phase (174.0 ± 63.5, 135.0 ± 29.9; P = 0.017).


CONCLUSIONS
We found that M 30 levels increase in patients with active ulcerative colitis. Our findings support the role of apoptosis demonstrated by serum M 30 levels in the pathogenesis of active ulcerative colitis.
*Department of Gastroenterology, Dişkapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey; †Department of Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey; and ‡Department of Biochemistry, Dişkapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Bora
B
Aktaş
Akif
A
Altınbaş
Omer
O
Başar
Barış
B
Yılmaz
Fuat
F
Ekiz
Zeynep
Z
Giniş
Gülfer
G
Oztürk
Sahin
S
Coban
Yaşar
Y
Tuna
Engin
E
Uçar
Elife
E
Erarslan
Osman
O
Yüksel
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood* / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053538:Keratin-18 / Q000097:blood*; D008297:Male; D010446:Peptide Fragments / Q000097:blood*; D011349:Proctitis / Q000097:blood / Q000175:diagnosis; D011379:Prognosis
D015415:Biomarkers; D053538:Keratin-18; C561463:M30 cytokeratin-18 peptide, human; D010446:Peptide Fragments