Pregnancies in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitor.
We presented our experience in chronic myeloid leukemia (CML) patients who conceived children and/or became pregnant while receiving tyrosine kinase inhibitor (TKI). Among 7 male patients, 7 pregnancies resulted in the birth of 7 healthy babies. Among 18 female patients, 8 ended in elective abortion; 3 had spontaneous abortion, and 7 carried to term, resulting in the birth of 8 healthy babies. All children have normal growth and development. All patients remain in TKI therapy and in good response. It is suggested that female patients are advised to practice adequate contraception. No special precautions apply for male patients receiving TKI.
Department of Hematology, Ruijin Hospital, Shanghai Institute of Hematology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Li
L
Zhou
Jian-Hua
JH
You
Wen
W
Wu
Jun-Min
JM
Li
Zhi-Xiang
ZX
Shen
Ai-Hua
AH
Wang
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D042341:Gonadal Hormones / Q000097:blood; D006801:Humans; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D055101:Semen Analysis; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D042341:Gonadal Hormones; D047428:Protein Kinase Inhibitors
Chronic myeloid leukemia; Imatinib; Nilotinib; Pregnancy