Racial and ethnic differences in the pathogenesis and clinical manifestations of uterine leiomyoma.
Uterine leiomyomas are the most common benign gynecologic condition. The prevalence is three times more common among women of African ethnicity. Disparity in this disease is evidenced by earlier age of onset, greater severity of symptoms, and different response to treatment. Although the pathogenesis of disease development is not completely known, growing evidence focuses on investigating the molecular mechanisms in disease development and the influence of ethnicity. Variation in the expression levels or function of estrogen and progesterone receptors, polymorphism of genes involved in estrogen synthesis and/or metabolism (COMT, CYP17), retinoic acid nuclear receptors (retinoid acid receptor-α, retinoid X receptor-α), and aberrant expression of micro-RNAs (miRNAs) are some of the molecular mechanisms that may be involved. Nutritional factors, such as vitamin D deficiency, might also contribute to the higher incidence in dark skinned populations who are also commonly suffer from hypovitaminosis D. Culture and environmental difference might have a role in disease development. Further analysis and better understanding of these mechanisms will provide insight into the molecular basis of racial disparities in leiomyoma formation and will help to develop new innovations in leiomyoma treatment.
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
William H
WH
Catherino
Heba M
HM
Eltoukhi
Ayman
A
Al-Hendy
D001741:Black or African American; D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease; D054624:Health Status Disparities; D006801:Humans; D007889:Leiomyoma / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D018231:Leiomyomatosis / Q000208:ethnology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D014481:United States; D014594:Uterine Neoplasms / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D044465:White People