A facile fabrication of alginate microbubbles using a gas foaming reaction.
Microbubble particles have been extensively utilized as temporal templates for various biomedical applications. This study proposes a facile strategy to obtain microbubble-containing alginate particles (i.e., microbubbles inside alginate gel particles, called alginate microbubbles). The chemical reaction of sodium bicarbonate and hydrogen peroxide to produce gaseous carbon dioxide and oxygen was utilized to form microbubbles within alginate particles. Uniform alginate particles were obtained by a stable needle-based droplet formation process. Kinetic reaction of gas formation was monitored for 2% alginate particles. The gas formation increased with the concentrations of sodium bicarbonate (1-5 wt%) and hydrogen peroxide (0-36.5 wt%).
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan.
Keng-Shiang
KS
Huang
Yung-Sheng
YS
Lin
Wan-Ru
WR
Chang
Yi-Ling
YL
Wang
Chih-Hui
CH
Yang
D000464:Alginates / Q000138:chemical synthesis / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry; D005740:Gases / Q000737:chemistry*; D020723:Glucuronic Acid / Q000138:chemical synthesis / Q000737:chemistry; D006603:Hexuronic Acids / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D045423:Microbubbles; D010316:Particle Size; D017693:Sodium Bicarbonate / Q000737:chemistry*
D000464:Alginates; D005740:Gases; D006603:Hexuronic Acids; D002245:Carbon Dioxide; D020723:Glucuronic Acid; D017693:Sodium Bicarbonate; D006861:Hydrogen Peroxide