The Prophylactic Effects of Zintoma and Ibuprofen on Post-endodontic Pain of Molars with Irreversible Pulpitis: A Randomized Clinical Trial.
BACKGROUND
Post endodontic pain is often linked to the inflammatory process as well as additional central mechanisms. The purpose of the present double-blind randomized clinical trial study was to compare the prophylactic effects of a derivative of Zingiber Officinale, Zintoma, and Ibuprofen on post endodontic pain of molars with irreversible pulpitis.


METHODS
The post endodontic pain of 72 enrolled patients suffering from irreversible pulpitis was assessed after prophylactic use of 400 mg Ibuprofen, 2 gr Zintoma and placebo. Using the Heft-Parker Visual Analogue Scale, the patients recorded their perceived pain before taking the medicament (baseline), immediately after and also at 4, 8, 12, 24, 48, and 72 h post one-visit endodontic treatment. The statistical analysis was done using Kruskal-Wallis, Mann-Whitney, and Freedman tests (P<0.05).


RESULTS
At all times, there was significant difference between the Ibuprofen and Zintoma (P<0.05) and also between the Ibuprofen and placebo (P<0.05). However, there was no significant difference between Zintoma and the placebo in any of time intervals (P>0.05). No side effects were observed.


CONCLUSIONS
The obtained results of the trial revealed that prophylactic use of 2 gr Zintoma is not an effective pain relieving agent.
Department of Endodontics, Dental School, Mazandaran University of Medical Sciences, Sari, Iran.
Mohsen
M
Ramazani
Mahmoud Reza
MR
Hamidi
Ali Akbar
AA
Moghaddamnia
Nahid
N
Ramazani
Nafiseh
N
Zarenejad
Analgesics; Anti-Inflammatory Agents; Ibuprofen; Non-Steroidal; Pain Measurement; Pulpitis; Visual Analogue Pain Scale; Zintoma