Validation of the Addenbrooke's Cognitive Examination III in frontotemporal dementia and Alzheimer's disease.
OBJECTIVE
The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia.


METHODS
A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study.


RESULTS
ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity.


CONCLUSIONS
The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD.
Neuroscience Research Australia, Sydney, N.S.W., Australia.
Sharpley
S
Hsieh
Samantha
S
Schubert
Christopher
C
Hoon
Eneida
E
Mioshi
John R
JR
Hodges
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology*; D001288:Attention / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D003627:Data Interpretation, Statistical; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis* / Q000523:psychology*; D006801:Humans; D007802:Language; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D015203:Reproducibility of Results; D013028:Space Perception / Q000502:physiology; D014706:Verbal Learning; D014796:Visual Perception / Q000502:physiology; D014888:Wechsler Scales