Histone post-translational modifications regulate autophagy flux and outcome.
Autophagy is an evolutionarily conserved process in eukaryotes by which cytoplasmic components including macromolecules and organelles are degraded by the lysosome/vacuole. Autophagy is implicated in a number of physiological processes important for human health and disease. Although primarily cytoprotective, autophagy can also contribute to cell death; it is thus important to understand what distinguishes the life or death decision in autophagic cells. Despite the fact that the execution of autophagy includes a unique set of cytoplasmic events, nuclear events, in particular transcriptional programs, have emerged as an important regulator of this process. In addition, a critical linkage was recently unveiled between specific histone posttranslational modifications and the transcriptional regulation of autophagy-related genes, which initiates a regulatory feedback loop, and serves as a key determinant of survival versus death responses upon autophagy induction.
Department of Oncology Pathology; Cancer Centrum Karolinska; Karolinska Institutet; Stockholm, Sweden.
Jens
J
Füllgrabe
Life Sciences Institute and Departments of Molecular, Cellular and Developmental Biology and Biological Chemistry; University of Michigan; Ann Arbor, MI USA.
Daniel J
DJ
Klionsky
Department of Oncology Pathology; Cancer Centrum Karolinska; Karolinska Institutet; Stockholm, Sweden.
Bertrand
B
Joseph
D000107:Acetylation; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D016923:Cell Death / Q000235:genetics / Q000502:physiology*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D006657:Histones
KAT8; MYST1; SIRT1; autophagic flux; cell death; hMOF; histone H4 lysine 16 acetylation (H4K16ac)