Protein adaptation: mitotic functions for membrane trafficking proteins.
Membrane trafficking and mitosis are two essential processes in eukaryotic cells. Surprisingly, many proteins best known for their role in membrane trafficking have additional 'moonlighting' functions in mitosis. Despite having proteins in common, there is insufficient evidence for a specific connection between these two processes. Instead, these phenomena demonstrate the adaptability of the membrane trafficking machinery that allows its repurposing for different cellular functions.
Division of Biomedical Cell Biology, Warwick Medical School, Gibbet Hill Road, Coventry, CV4 7AL, UK. s.j.royle@warwick.ac.uk
Stephen J
SJ
Royle
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism*; D018385:Centrosome / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D018386:Kinetochores / Q000378:metabolism; D059566:M Phase Cell Cycle Checkpoints / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000378:metabolism / Q000502:physiology; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D011485:Protein Binding; D021381:Protein Transport / Q000502:physiology
D018797:Cell Cycle Proteins; D002966:Clathrin; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; C120551:TACC3 protein, human