Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes.
We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; n  =  19; mean age  = 10.35 years), Cornelia de Lange (CdLS; n  =  15; mean age  = 12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; n  =  19; mean age  =  8.80 years) syndromes. The proportion of individuals meeting the ASD cutoff on the Social Communication Questionnaire was significantly higher in the AS and CdLS groups than in the CdCS group (p < .01). The groups demonstrated divergent social behavior profiles during social conditions in which adult availability, adult familiarity, and social demand were manipulated. Social enjoyment was significantly heightened in AS, whereas social approaches were heightened in individuals with CdCS. Social motivation, social communication, and enjoyment were significantly lower in CdLS. The findings highlight the importance of detailed observation when evaluating ASD and social behavior in genetic syndromes.
Cerebra Center for Neurodevelopmental Disorders, Psychology, University of Birmingham, Birmingham, Edgbaston B15 2TT, United Kingdom. j.j.moss@bham.ac.uk
Joanna
J
Moss
Patricia
P
Howlin
Richard Patrick
RP
Hastings
Sarah
S
Beaumont
Gemma M
GM
Griffith
Jane
J
Petty
Penny
P
Tunnicliffe
Rachel
R
Yates
Darrelle
D
Villa
Chris
C
Oliver
D000293:Adolescent; D000328:Adult; D017204:Angelman Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000453:epidemiology / Q000503:physiopathology*; D002675:Child, Preschool; D015897:Comorbidity; D003410:Cri-du-Chat Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D003635:De Lange Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D011581:Psychological Tests; D036301:Qualitative Research; D012919:Social Behavior; D011795:Surveys and Questionnaires; D055815:Young Adult