Generation of 4-((trifluoromethyl)thio)-2H-benzo[e][1,2]thiazine 1,1-dioxides via a reaction of trifluoromethanesulfanylamide with 2-(2-alkynyl)benzenesulfonamide.
The incorporation of the (trifluoromethyl)thio group into the benzo[e][1,2]thiazine 1,1-dioxide scaffold via a reaction of trifluoromethanesulfanylamide with 2-(2-alkynyl)benzenesulfonamide is reported. The transformation proceeds under mild conditions to afford the 4-((trifluoromethyl)thio)-2H-benzo[e][1,2]thiazine 1,1-dioxides in moderate to good yields.
Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China.
Qing
Q
Xiao
Jie
J
Sheng
Zhiyuan
Z
Chen
Jie
J
Wu
D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry*; D054879:Halogenation; D008745:Methylation; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry*; D013843:Thiazines / Q000138:chemical synthesis / Q000737:chemistry*; D000096926:Benzenesulfonamides
D001555:Benzene Derivatives; D010087:Oxides; D013438:Sulfhydryl Compounds; D013449:Sulfonamides; D013843:Thiazines; D000096926:Benzenesulfonamides