Patient-reported upper extremity outcome measures used in breast cancer survivors: a systematic review.
OBJECTIVE
(1) To identify English-language published patient-reported upper extremity outcome measures used in breast cancer research and (2) to examine construct validity and responsiveness in patient-reported upper extremity outcome measures used in breast cancer research.


METHODS
PubMed, Cumulative Index to Nursing and Allied Health Literature, and ProQuest MEDLINE databases were searched up to February 5, 2013.


METHODS
Studies were included if a patient-reported upper extremity outcome measure was administered, the participants were diagnosed with breast cancer, and the study was published in English.


METHODS
A total of 865 articles were screened. Fifty-nine full text articles were assessed for eligibility. A total of 46 articles met the initial eligibility criteria for aim 1. Eleven of these articles reported means and SDs for the outcome scores and included a comparison group analysis for aim 2.


RESULTS
Construct validity was evaluated by calculating effect sizes for known-group differences in 6 studies using the Disabilities of Arm, Shoulder and Hand (DASH), University of Pennsylvania Shoulder Score, Shoulder Disability Questionnaire-Dutch, and 10 Questions by Wingate. Responsiveness was analyzed comparing a treatment and control group by calculating the coefficient of responsiveness in 5 studies for the DASH and 10 Questions by Wingate.


CONCLUSIONS
Eight different patient-reported upper extremity outcome measures have been reported in the peer-review literature for women with breast cancer; some that were specifically developed for breast cancer survivors (n=3) and others that were not (n=5). Based on the current evidence, we recommend administering the DASH to assess patient-reported upper extremity function in breast cancer survivors because the DASH has the most consistently large effects sizes for construct validity and responsiveness. Future large studies are needed for more definitive recommendations.
Department of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville, FL; K12 Scholar, Department of Physical Therapy, University of Florida, Gainesville, FL. Electronic address: s.harrington@unf.edu.
Shana
S
Harrington
Department of Physical Therapy, Virginia Commonwealth University - Medical College of Virginia Campus, Richmond, VA.
Lori A
LA
Michener
Rehabilitation Medicine Service, Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY.
Tiffany
T
Kendig
Department of Physical Therapy, School of Health Technology and Management, Stony Brook University, Stony Brook, NY.
Susan
S
Miale
Department of Physical Therapy, University of Florida, Gainesville, FL.
Steven Z
SZ
George
D001132:Arm; D001943:Breast Neoplasms / Q000503:physiopathology* / Q000523:psychology; D004185:Disability Evaluation; D005260:Female; D006225:Hand; D006801:Humans; D017063:Outcome Assessment, Health Care; D026741:Physical Therapy Modalities; D011594:Psychometrics; D015203:Reproducibility of Results; D057566:Self Report; D012782:Shoulder; D034941:Upper Extremity / Q000503:physiopathology*
Breast neoplasms; CI; DASH; Disabilities of Arm, Shoulder and Hand; ES; KAPS; Kwan's arm problem scale; Outcome assessment (health care); Rehabilitation; ULDQ; Upper extremity; confidence interval; effect size; upper limb disability questionnaire