Sympathetic neuropathy and dysphagia following doxycycline sclerotherapy.
This case report demonstrates neurologic sequela following treatment with doxycycline sclerotherapy. A six-week-old child presented with respiratory distress from a macrocystic lymphatic malformation, extending from the skull base to the anterior mediastinum. Following doxycycline sclerotherapy, the airway symptoms resolved; however, the child developed silent aspiration and Horner's syndrome. Two months following treatment the patient resumed oral diet and at one year post-intervention there has been no recurrence of symptoms, with only mild ptosis remaining. While neuropathies following doxycycline sclerotherapy have been described, aspiration has never been documented. This case demonstrates a single patient's clinical course and resolution of their neuropathies.
Medical College of Wisconsin, United States.
Kevin L
KL
Wang
Robert H
RH
Chun
Joseph E
JE
Kerschner
Cecille G
CG
Sulman
D000402:Airway Obstruction / Q000175:diagnosis / Q000209:etiology; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology; D004318:Doxycycline / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006732:Horner Syndrome / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D044148:Lymphatic Abnormalities / Q000473:pathology* / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000379:methods; D053120:Respiratory Aspiration / Q000209:etiology* / Q000503:physiopathology; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis / Q000628:therapy; D018570:Risk Assessment; D015911:Sclerotherapy / Q000009:adverse effects* / Q000379:methods
D004318:Doxycycline
Aspiration; Complication; Doxycycline sclerotherapy; Horner's syndrome; Lymphatic malformation