[Tumor necrosis factor-alpha in a children population with overweight].
The child overweight is associated with overweight/obesity at the adult age. The obese adipose tissue produces an increase of proinflammatory cytokines as the tumor necrosis factor alpha (TNF-α), causing a deleterious effect on vascular functions. The aim of this work was to evaluate TNF-α levels in a children's population with overweight and its relationship with clinical and laboratory variables. Thirty overweight children were studied, with ages between 8-13 years old, and twenty control children. In both groups waist circumference was measured and body mass index (BMI) calculated. The inclusion criterium was a >85th < 95 th BMI percentile for age and sex. In both groups were determined: fasting blood glucose (glucose-oxidase method); plasma insulin (ECLIA); plasma fibrinogen (Fg, Clauss method); high sensitivity C reactive protein (hsCRP, immunoturbidimetric method); plasma myeloperoxidase (ELISA); TNF-α (ELISA); lipid profile (enzymatic methods); erythrosedimentation rate (ESR) and homeostasis model assessment index (HOMA). Data were expressed as the median and interquartile range. Correlations between variables were investigated with the Spearman's coefficient. A p < 0.05 was considered significant. The TNF-α levels were higher in overweight children [15.4 (13.2-24.0) vs. 12.7 (11.2-14.8) pg/ml; p = 0.028]. Levels of Fg, plasma insulin, HOMA index, uCRP and triglycerides were also statistically significant higher than the control group. The TNF-α was positively correlated with the waist circumference (r = 0.654; p = 0.021). The high TNF-α levels found, with the CRP and Fg levels, confirm a low grade proinflammatory state associated to abdominal obesity in the studied population.
Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Argentina.
Teresita Del R
Tdel R
Carrizo
Elba I
EI
Díaz
María S
MS
Velarde
María M
MM
Prado
María C
MC
Bazán
Adela V
AV
Abregú
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D050177:Overweight / Q000097:blood*; D012016:Reference Values; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055105:Waist Circumference
D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D002784:Cholesterol
TNF‐α; inflammation; overweight