Direct peptide lipidation through thiol-ene coupling enables rapid synthesis and evaluation of self-adjuvanting vaccine candidates.
A radical lipidation: Application of a novel thiol-ene lipidation enables the one-step synthesis of self-adjuvanting antigenic peptides as vaccine candidates. The resultant monoacyl lipopeptides are shown to activate monocytes in a robust manner.
School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland Central, 1142 (New Zealand).
Tom H
TH
Wright
Anna E S
AE
Brooks
Alicia J
AJ
Didsbury
Julie D
JD
MacIntosh
Geoffrey M
GM
Williams
Paul W R
PW
Harris
P Rod
PR
Dunbar
Margaret A
MA
Brimble
D000941:Antigens / Q000737:chemistry / Q000276:immunology; D006801:Humans; D055666:Lipopeptides / Q000138:chemical synthesis* / Q000276:immunology*; D010455:Peptides / Q000737:chemistry / Q000276:immunology; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014612:Vaccines / Q000138:chemical synthesis* / Q000494:pharmacology
D000941:Antigens; D055666:Lipopeptides; D010455:Peptides; D013438:Sulfhydryl Compounds; D014612:Vaccines
adjuvants; immunology; peptides; thiol-ene reaction; vaccines