Role of blind closed pleural biopsy in the managment of pleural exudates.
BACKGROUND
The performance of blind closed pleural biopsy (BCPB) in the study of pleural exudates is controversial.


OBJECTIVE
To assess the diagnostic yield of BCPB in clinical practice and its role in the study of pleural exudates.


METHODS
Data were retrospectively collected on all patients who underwent BCPB performed between January 1999 and December 2011.


RESULTS
A total of 658 BCPBs were performed on 575 patients. Pleural tissue was obtained in 590 (89.7%) of the biopsies. A malignant pleural effusion was found in 35% of patients. The cytology and the BCPB were positive in 69.2% and 59.2% of the patients, respectively. Of the patients with negative cytology, 21 had a positive BCPB (diagnostic improvement, 15%), which would have avoided one pleuroscopy for every seven BCPBs that were performed. Of the 113 patients with a tuberculous effusion, granulomas were observed in 87 and the Lowenstein culture was positive in an additional 17 (sensitivity 92%). The overall sensitivity was 33.9%, with a specificity and positive predictive value of 100%, and a negative predictive value of 71%. Complications were recorded in 14.4% of patients (pneumothorax 9.4%; chest pain 5.6%; vasovagal reaction, 4.1%; biopsy of another organ 0.5%).


CONCLUSIONS
BCPB still has a significant role in the study of a pleural exudate. If an image-guided technique is unavailable, it seems reasonable to perform BCPB before resorting to a pleuroscopy. These results support BCPB as a relatively safe technique.
Marco F
MF
Pereyra
Esther
E
San-José
Lucía
L
Ferreiro
Antonio
A
Golpe
José
J
Antúnez
Francisco-Javier
FJ
González-Barcala
Ihab
I
Abdulkader
José M
JM
Álvarez-Dobaño
Nuria
N
Rodríguez-Núñez
Luis
L
Valdés
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010994:Pleura / Q000473:pathology*; D016066:Pleural Effusion, Malignant / Q000473:pathology*; D012189:Retrospective Studies; D055815:Young Adult