Palladium-catalyzed oxidative direct C-H/C-H cross coupling of anilides with β-keto esters.
A Pd(II)-catalyzed oxidative direct C(sp(2))-H/C(sp(3))-H cross coupling of anilides with α-dicarbonyl compounds with Mn(OAc)3·2H2O as the oxidant is reported and this protocol provides facile access to α-aryl malonates and β-keto esters in good yields and regioselectivity.
State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Wai-Wing
WW
Chan
Zhongyuan
Z
Zhou
Wing-Yiu
WY
Yu