Polymorphism of angiotensinogen gene M235T in myocardial infarction and brain infarction: a meta-analysis.
The angiotensinogen (AGT) gene M235T polymorphism has been reported to be associated with myocardial infarction (MI) and brain infarction (BI), but the results remain inconclusive. This meta-analysis was designed to clarify these controversies. Electronic databases were systematically searched before February 2013. A total of 38 studies with 17304 subjects met our inclusion criteria. In East Asian group, significant association was found between AGT M235T polymorphism and risk of MI (for dominant model: OR=1.79; 95% CI=1.04-3.06; for recessive model OR=2.01; 95% CI=1.21-3.36; for additive model OR=1.79; 95% CI=1.14-2.86) as well as BI (for dominant model: OR=1.66; 95% CI=1.22-2.27; for recessive model OR=1.78, 95% CI=1.29-2.46; for additive model: OR=1.64, 95% CI=1.34-2.00), while the M235T polymorphism did not impact the risk of MI in total population and other ethnicity. In the subgroup analyses by gender and age, there was lack of evidence for the association. This meta-analysis suggested an association between the M235T polymorphism and MI as well as BI in East Asian population. Further studies with larger numbers of worldwide participants are needed to understand the genetic basis of MI and BI.
Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Xinyue
X
Liang
Jie
J
Qiu
Xiangju
X
Liu
Xiao
X
Li
Shaohua
S
Zhao
Jing
J
Wang
Yabing
Y
Ma
Haiqing
H
Gao
D000808:Angiotensinogen / Q000235:genetics*; D044466:Asian People; D020520:Brain Infarction / Q000235:genetics*; D005202:Asia, Eastern; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People
D000808:Angiotensinogen
AGT; Angiotensinogen; BI; Brain infarction; CI; Gene polymorphism; HWE; Hardy–Weinberg equilibrium; MI; Meta-analysis; Myocardial infarction; OR; RAAS; angiotensinogen; brain infarction; confidence interval; myocardial infarction; odds ratio; renin–angiotensin–aldosterone system