Molecular approaches and biomarkers for detection of Mycobacterium tuberculosis.
Tuberculosis (TB) continues to be a public health emergency, compounded by the lack of adequate diagnostic testing in many regions of the world. New advances in the molecular detection of Mycobacterium tuberculosis, including faster and simpler nucleic acid amplification tests, have resulted in rapid and cost-effective methods to diagnose TB and test for drug resistance. Ongoing research on biomarkers for TB infection may lead to new tests for blood, urine, breath, and sputum. Sustained investment in the development and dissemination of diagnostic tests for TB is critical for increasing TB case finding, placing patients on appropriate treatment, and reducing transmission.
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, L235, Stanford, CA 94305, USA. rluo2@stanford.edu
Robert F
RF
Luo
Niaz
N
Banaei
D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000652:urine; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D055432:Metabolomics / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D040901:Proteomics / Q000379:methods; D014376:Tuberculosis / Q000175:diagnosis*
D015415:Biomarkers
Biomarkers; Molecular diagnostics; Mycobacterium tuberculosis; Nucleic acid amplification tests