Association of possible osteopetrosis with acute myeloid leukaemia in a child.
Osteopetrosis is a rare disease characterised by an increase in bone mass, skeletal malformations and bone marrow failure due to defective bone resorption. We report a 3-month-old male child presented with chest infections, failure to thrive and hepatosplenomegaly and diagnosed with osteopetrosis associated with acute myeloid leukaemia M3 type (AML-M3). The patient died on day 7 of admission due to respiratory failure. To our knowledge, this is the first case where both osteopetrosis and AML is diagnosed in a patient.
Department of Pediatrics, Institute of Medical Sciences, Varanasi, Uttar Pradesh, India.
Rajniti
R
Prasad
B P
BP
Jaiswal
O P
OP
Mishra
Utpal Kant
UK
Singh
D005183:Failure to Thrive / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D010022:Osteopetrosis / Q000150:complications* / Q000175:diagnosis*