Expression analysis of Foxp3 in T cells from bovine leukemia virus infected cattle.
In the present study, we monitored Foxp3(+) T cells in bovine leukemia virus (BLV)-infected cattle. By flow cytometric analysis, the proportion of Foxp3(+) CD4(+) cells from persistent lymphocytotic cattle was significantly increased compared to control and AL cattle. Interestingly, the proportion of Foxp3(+) CD4(+) cells correlated positively with the increased number of lymphocytes, virus titer and virus load, whereas it inversely correlated with IFN-γ mRNA expression, suggesting that Foxp3(+) CD4(+) T cells in cattle have a potentially immunosuppressive function. Further studies are necessary to elucidate the detailed mechanism behind the increased Treg during BLV infection.
Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.
Saori
S
Suzuki
Satoru
S
Konnai
Tomohiro
T
Okagawa
Ryoyo
R
Ikebuchi
Tatsuya
T
Shirai
Yuji
Y
Sunden
Claro N
CN
Mingala
Shiro
S
Murata
Kazuhiko
K
Ohashi
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002417:Cattle; D016583:Enzootic Bovine Leukosis / Q000235:genetics* / Q000276:immunology / Q000821:virology; D005260:Female; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors / Q000235:genetics* / Q000276:immunology; D015870:Gene Expression; D001909:Leukemia Virus, Bovine / Q000502:physiology*
D051858:Forkhead Transcription Factors
CD4; Foxp3; bovine leukemia virus (BLV)