[Progress in genetic study of aortic dissection].
Genetic study can provide important insight into the etiology of aortic dissection. To explore the pathogenesis and natural history of aortic dissection, a number of genes have been identified through microarray chip screening and undergone testing of polymorphisms to find mutations strongly associated with the disease. The results suggested aortic dissection to be a multi-gene disorder. Multiple genes probably work together to promote its development. Several diseases with a genetic predisposition are closely connected with aortic dissection, which also implied a role of genetic changes and malfunction in this disease.
Department of Vascular Surgery, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai 200032, P. R. China. fu.weiguo@zs-hospital.sh.cn.
Yong-sheng
YS
Li
Wei-guo
WG
Fu
Zhi-hui
ZH
Dong
Li-xin
LX
Wang
Yu-qi
YQ
Wang
D000784:Aortic Dissection / Q000235:genetics*; D001014:Aortic Aneurysm / Q000235:genetics*; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic