Enantioselective intermolecular formal [3 + 3] cycloaddition of 2,3-disubstituted indoles with acrolein.
An expedient enantioselective synthesis of highly substituted hydrocarbazoles has been realized by an organocatalyzed formal [3 + 3] cycloaddition between acrolein and 2,3-disubstituted indoles. Tricyclic hydrocarbazoles were obtained from a broad range of 2,3-disubstituted indoles and acrolein in good to excellent yields and excellent enantioselectivites.
Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, China.
Jianbiao
J
Huang
Long
L
Zhao
Yong
Y
Liu
Weiguo
W
Cao
Xiaoyu
X
Wu
D000171:Acrolein / Q000737:chemistry*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D002227:Carbazoles; D007211:Indoles; D000171:Acrolein