Sesterterpenoids isolated from a northeastern Pacific Phorbas sp.
Four new sesterterpenoids, ansellone B (4), phorbadione (5), secoepoxyansellone A (6), and alotaketal C (7), have been isolated from specimens of the sponge Phorbas sp. collected in British Columbia. Ansellone B (4) has an unprecedented heterocyclic skeleton featuring an oxocane ring, and secoepoxyansellone A (6) is the first example of the degraded "secoansellane" sesterterpenoid carbon skeleton. Alotaketal C (7) is an activator of cAMP signaling in HEK cells.
Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
Julie
J
Daoust
Min
M
Chen
Meng
M
Wang
David E
DE
Williams
Miguel Angel
MA
Garcia Chavez
Yan Alexander
YA
Wang
Catherine E
CE
Merchant
Angelo
A
Fontana
Timothy J
TJ
Kieffer
Raymond J
RJ
Andersen
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D057809:HEK293 Cells; D006801:Humans; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D054830:Sesterterpenes; D000242:Cyclic AMP