The contribution of melanocytes to pathological scar formation during wound healing.
Both hypertrophic scars and keloid scars are caused by abnormal wound healing, the key feature of which is excess collagen fiber secretion by fibroblasts. Many different factors could affect the process of hypertrophic scar and keloid formation, but most have not been identified to date. We assume that, during wound healing, melanocytes from the stratum basale contact or interact with fibroblasts from the dermal layers after the basal membrane is damaged, which in turn facilitates fibroblast proliferation and the secretion and deposition of collagen. This plays a significant role in the generation of hypertrophic scars and keloids.
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China 200011.
Fu-Lei
FL
Gao
Rong
R
Jin
Lu
L
Zhang
Yu-Guang
YG
Zhang
Melanocyte; fibroblast; keloid; scar; wound healing