Impact of adiponectin and leptin on long-term adverse events in Japanese patients with acute myocardial infarction. Results from the Nagoya Acute Myocardial Infarction Study (NAMIS).
BACKGROUND
Low adiponectin levels and high leptin levels are associated with a high incidence of developing cardiovascular disease. However, the relationship between the levels of these adipokines and the development of adverse events after acute myocardial infarction (AMI) remains unclear.


RESULTS
This study enrolled 724 Japanese subjects with AMI who underwent successful emergency percutaneous coronary intervention (PCI). Their serum adiponectin and leptin levels were measured 7 days after AMI onset. There were 63 adverse events during the 3-year follow-up. The levels of adiponectin and leptin and the leptin to adiponectin ratio, were significantly associated with adverse events [hazard ratio 2.08 (95% confidence interval (CI) 1.33-3.24), P=0.001; hazard ratio 0.62 (95% CI 0.43-0.90), P=0.012; hazard ratio 0.59 (95% CI 0.45-0.76), P<0.001, respectively]. The leptin to adiponectin ratio remained a significant independent predictor of adverse events during long-term follow-up in a multivariable analysis [adjusted hazard ratio 0.60 (95% CI 0.43-0.83), P=0.002].


CONCLUSIONS
Higher adiponectin and lower leptin levels are associated with a high incidence of adverse events in Japanese patients after AMI, and the leptin to adiponectin ratio independently predicts prognosis after AMI.
Department of Cardiology, Nagoya University Graduate School of Medicine.
Yasuhiro
Y
Morita
Kengo
K
Maeda
Takahisa
T
Kondo
Hideki
H
Ishii
Kyoko
K
Matsudaira
Naoki
N
Okumura
Hirotsugu
H
Mitsuhashi
Rei
R
Shibata
Toyoaki
T
Murohara
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D044466:Asian People; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D013997:Time Factors
C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin