Gene expression analysis of aberrant signaling pathways in meningiomas.
Examining aberrant pathway alterations is one method for understanding the abnormal signals that are involved in tumorigenesis and tumor progression. In the present study, expression arrays were performed on tumor-related genes in meningiomas. The GE Array Q Series HS-006 was used to determine the expression levels of 96 genes that corresponded to six primary biological regulatory pathways in a series of 42 meningiomas, including 32 grade I, four recurrent grade I and six grade II tumors, in addition to three normal tissue controls. Results showed that 25 genes that were primarily associated with apoptosis and angiogenesis functions were downregulated and 13 genes frequently involving DNA damage repair functions were upregulated. In addition to the inactivation of the neurofibromin gene,NF2, which is considered to be an early step in tumorigenesis, variations of other biological regulatory pathways may play a significant role in the development of meningioma.
Neuro-Oncogenetics Laboratory, Research Unit, Madrid, Spain ;
Miguel
M
Torres-Martín
Victor
V
Martinez-Glez
Carolina
C
Peña-Granero
Alberto
A
Isla
Luis
L
Lassaletta
Jose M
JM
DE Campos
Giovanny R
GR
Pinto
Rommel R
RR
Burbano
Bárbara
B
Meléndez
Javier S
JS
Castresana
Juan A
JA
Rey
gene expression arrays; meningioma; neurofibromin gene; schwannoma; signaling pathways