The use of extemporaneously compounded 1% tetracaine to improve adherence with clotrimazole 1% topical solution in the treatment of ear infection: a case report.
For most medically amenable conditions, adherence to drug therapy is a necessary condition for a successful outcome. Drug side effects, especially pain, can interfere with the desired outcome. We report a case of non-adherence due to severe pain associated with the topical use of clotrimazole 1% solution in the ear. Instillation of tetracaine 1% solution prior to the administration of the clotrimazole blocked the pain sensation allowing the patient to successfully complete the antifungal therapy.
Department of Pharmaceutical Sciences, Southern Illinois University Edwardsville School of Pharmacy, Edwardsville, IL, USA. Electronic address: wkollin@siue.edu.
William M
WM
Kolling
Timothy B
TB
McPherson
Jonathan L
JL
McJunkin
D000287:Administration, Topical; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003022:Clotrimazole / Q000008:administration & dosage / Q000009:adverse effects*; D004339:Drug Compounding; D004433:Earache / Q000139:chemically induced* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010032:Otitis Externa / Q000188:drug therapy; D059249:Otomycosis / Q000188:drug therapy; D013748:Tetracaine / Q000008:administration & dosage*
D000779:Anesthetics, Local; D000935:Antifungal Agents; D013748:Tetracaine; D003022:Clotrimazole