Oxidative stress during development of alcoholic fatty liver: therapeutic potential of cacao polyphenol.
The lipid and antioxidative/oxidative profiles of livers from rats fed an ethanol liquid diet for 8 weeks provided evidence for an involvement of oxidative stress (e.g., phospholipid peroxidation) in the development of alcoholic fatty liver (AFL), possibly in an early stage. Cacao polyphenol supplementation produced an ameliorating effect, and may help in AFL prevention.
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University.
Koichiro
K
Suzuki
Kiyotaka
K
Nakagawa
Taiki
T
Miyazawa
Shunji
S
Kato
Fumiko
F
Kimura
Masanori
M
Kamei
Teruo
T
Miyazawa
D000818:Animals; D002099:Cacao / Q000737:chemistry; D000431:Ethanol / Q000008:administration & dosage; D005235:Fatty Liver, Alcoholic / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D059808:Polyphenols / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats
D059808:Polyphenols; D000431:Ethanol