P-chirogenic organocatalysts: application to the aza-Morita-Baylis-Hillman (aza-MBH) reaction of ketimines.
The P-chirogenic organocatalysts were found to promote the enantioselective aza-Morita-Baylis-Hillman reaction of ketimines derived from acyclic α-keto esters. In the P-chirogenic organocatalyzed aza-MBH reactions, α,α-disubstituted α-amino acid derivatives were obtained in high yields with high enantioselectivities (up to 97% ee).
The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. sasai@sanken.osaka-u.ac.jp.
Shinobu
S
Takizawa
Emmanuelle
E
Rémond
Fernando Arteaga
FA
Arteaga
Yasushi
Y
Yoshida
Vellaisamy
V
Sridharan
Jérôme
J
Bayardon
Sylvain
S
Jugé
Hiroaki
H
Sasai
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D007097:Imines; D009570:Nitriles; C542835:ketimine