[Influence of ademol on NO metabolism indices in rats with modeling myocardial infarction].
It was established in experiments on the rats in the acute period of modeling pituitrin-isadrin myocardial infarction the formation of nitrogen monoxide decreases along with its accelerated transformation into peroxynitrite. It was evidenced by more than double inhibition of NO synthase activity in the myocardium and by decreasing the amount of nitrates on the background of the increasing level of peroxynitrites' marker--nitrotyrosine by 246.6% at an average. Experimental therapy of rats by ademol which is a derivate of adamantan (1-adamantiloxy-3-morpholino-2 propanol hydrochloride) better than by corvitin normalizes the processes of synthesis of nitric oxide. At the same time ademol probably exceeded the reference drug in ability to increase NO synthase activity and amount of nitrate, and promoted a decrease of the level of nitrotyrosine in the myocardium on the average by 36.3; 50.6 and 12.7%, respectively. Corrective influence of ademol on indicators of metabolism in NO system under the conditions of acute cardiac ischemia indicates to promicing development of domestic cardioprotector on its base.
O A
OA
Khodakivs'kyĭ
S V
SV
Pavlov
N V
NV
Bukhtiiarova
D000218:Adamantane / Q000494:pharmacology; D000818:Animals; D001581:Benzothiadiazines / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007545:Isoproterenol; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism*; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D030421:Peroxynitrous Acid / Q000378:metabolism; D010909:Pituitary Hormones, Posterior; D051381:Rats; D014443:Tyrosine / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
D001581:Benzothiadiazines; D002316:Cardiotonic Agents; D005419:Flavonoids; D010909:Pituitary Hormones, Posterior; C558416:corvitin; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; C002744:3-nitrotyrosine; C511328:flumethiazide; D014443:Tyrosine; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D007545:Isoproterenol; D000218:Adamantane