The associations between the Val158Met in the catechol-O-methyltransferase (COMT) gene and the risk of uterine leiomyoma (ULM).
The Val158Met polymorphism of the COMT gene has been implicated in susceptibility to uterine leiomyoma (ULM), but the reported results were inconclusive. The aim of the study was to evaluate the Val158Met polymorphism of the COMT gene and the risk of ULM by meta-analysis. A comprehensive electronic search for relevant articles was conducted in Pubmed, Embase, CNKI, Wanfang, and Weipu databases. Statistical analysis was performed by using the Revman4.2 software and Stata10.0 software. A total of 7 articles including 12 case-control studies were identified in this meta-analysis. The results showed that the polymorphism was associated with decreased risk of ULM (Met/Met+Val/Met vs. Met/Met: OR=0.84, 95% CI=0.70-0.99, Z=2.07, p=0.04). In the subgroup analyses by ethnicity, significant decreased risk was found among the black populations (OR=0.68, 95% CI=0.48-0.97, Z=2.15, p=0.03). The current meta-analysis suggested that the Val158Met polymorphism in the COMT gene was associated with decreased risk of ULM, especially in the black population. Future studies are needed to validate our conclusions.
Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Chengdu 610041, Sichuan, PR China.
Yi
Y
Feng
Xitong
X
Zhao
Chunfen
C
Zhou
Lu
L
Yang
Yingwei
Y
Liu
Ce
C
Bian
Jinhai
J
Gou
Xiaojuan
X
Lin
Zhenling
Z
Wang
Xia
X
Zhao
D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D020125:Mutation, Missense; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups / Q000235:genetics; D014594:Uterine Neoplasms / Q000235:genetics*
D002394:Catechol O-Methyltransferase
CI; COMT; COMT gene; Catechol-O-methyltransferase; F; GWA; I; I statistic for heterogeneity; Meta-analysis; OR; Phet; Polymorphism; ULM; Uterine leiomyoma; Z; Z value for Q statistic; catechol-O-methyltransferase gene; confidence interval; fixed model; genome-wide association; odds ratio; p; p value for heterogeneity; p-value for Q statistic; uterine leiomyoma