Synthetic routes to magnetic nanoparticles for MPI.
Magnetic particle imaging (MPI) is a new imaging technique for visualizing the three-dimensional distribution of superparamagnetic iron oxide nanoparticles with specific properties (MPI tracers). Initial results obtained with MPI using superparamagnetic iron oxide as blood pool markers suggest that the method has great potential for cardiovascular imaging. Conversely, no clinically approved MPI tracers currently exist that could be used to exploit this potential of MPI. This article describes thermal decomposition and coprecipitation, two relevant methods for synthesizing and optimizing superparamagnetic iron oxide nanoparticles for MPI. Furthermore it summarizes the recent literature on MPI tracers and explores what can be learned from structural studies with Resovist(®) for novel synthesis approaches.
Harald
H
Kratz
Dietmar
D
Eberbeck
Susanne
S
Wagner
Matthias
M
Taupitz
Jörg
J
Schnorr
D003460:Crystallization / Q000379:methods*; D005590:Fractional Precipitation / Q000379:methods*; D006358:Hot Temperature; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D057054:Molecular Imaging / Q000379:methods*; D010316:Particle Size
D058185:Magnetite Nanoparticles