Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues.
The synthesis of several analogues of ma'edamines A and B are reported. The synthesized compounds were tested on hormone receptor positive and HER2 positive breast cancer cell lines, by MTT assay. MED-114, 115, 117, 119, 120, 124, 128 and 131 were found to be equally active as Lapatinib on HER2 +ve cell line SKBR3.
GVK Biosciences Private Limited, Medicinal Chemistry Division, 28A, IDA, Nacharam, Hyderabad 500076, India.
Sanjay
S
Saha
Ch Venkata Ramana
ChV
Reddy
Shili
S
Xu
Saranya
S
Sankar
Nouri
N
Neamati
Balaram
B
Patro
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001688:Biological Products; D011719:Pyrazines; C587368:ma'edamine A; C587369:ma'edamine B
Anticancer; Antiproliferative activity; Breast cancer; HER2; Marine natural products