Cu(I)-catalyzed intramolecular oxidative C-H amination of 2-aminoacetophenones: a convenient route toward isatins.
2-Aminoaryl methyl ketones undergo intramolecular oxidative C-H amination to give the corresponding substituted isatins under an oxygen atmosphere in the presence of [CuI(bpy)]2.
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan. chcheng@mx.nthu.edu.tw.
Pang-Chi
PC
Huang
Parthasarathy
P
Gandeepan
Chien-Hong
CH
Cheng
D000098:Acetophenones / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007510:Isatin / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000098:Acetophenones; C055495:2-aminoacetophenone; D003300:Copper; D007510:Isatin