Alterations in placental pendrin expression in pre-eclampsia.
BACKGROUND
Pendrin is an integral membrane protein and plays a key role in extracellular fluid volume and blood pressure control. We aimed to investigate the relationship between pendrin immunostaining intensity in normal and pre-eclamptic placental tissue.


METHODS
Fifty-six placental tissues, of which 26 were in pre-eclamptic, and 30 were in control group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense.


RESULTS
There was more positive immunstaining in the pre-eclamptic placenta compared to the controls (p<0.001). A significant positive correlation was observed between immunostaining level and diastolic blood pressure (r=0.533, p=0.005) in the pre-eclamptic group. However, no significant correlation was observed between any condition and immunostaining level in the control group.


CONCLUSIONS
Placentas in the pre-eclamptic group were significantly more immunostained with pendrin than were those in the control group. In addition, a positive correlation between immunostaining intensity with pendrin and both systolic and diastolic blood pressure were observed. Pendrin may play a role in the mechanism of severe hypertension in women with pre-eclampsia.
Department of Obstetrics and Gynecology, School of Medicine, Abant Izzet Baysal University , Bolu , Turkey .
Ahmet
A
Karatas
Havva
H
Erdem
Mustafa
M
Albayrak
Murat
M
Oktay
Tulay
T
Ozlu
Bulent
B
Cakmak
Fatih
F
Keskin
Melahat Emine
ME
Donmez
D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D026901:Membrane Transport Proteins / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012189:Retrospective Studies; D000076988:Sulfate Transporters; D055815:Young Adult
D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; D000076988:Sulfate Transporters