[Interleukin-1ß, seizures and neuronal cell death].
Epilepsy is a neurological disorder affecting almost 1% of the world population. Experimental human and animal studies suggest that inflammation mediators, like cytokines, participate in the physiopathology of epilepsy. Interleukin-1beta (IL-1ß) could influence susceptibility for seizures, as well as neuronal death caused by seizures, although some findings are contradictory. This document reviews the current knowledge establishing a connection between IL-1ß, seizures and neuronal death.
Universidad Veracruzana, Xalapa, México.
Jesús S
JS
Medel-Matus
Libia X
LX
Cortijo-Palacios
Dulce M
DM
Álvarez-Croda
Joel
J
Martínez-Quiroz
María L
ML
López-Meraz
D000818:Animals; D016923:Cell Death / Q000502:physiology; D006801:Humans; D053583:Interleukin-1beta / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012640:Seizures / Q000209:etiology*
D053583:Interleukin-1beta