Effect of water soluble carrier on dissolution profiles of diclofenac sodium.
Pharmaceutical aviailability of diclofenac sodium from solid dispersions of PEG 6000 have been studied in comparison to those of the corresponding physical mixtures and pure diclofenac sodium. The diclofenac sodium is poorly water soluble drug. The properties of diclofenac sodium-PEG 6000 solid dispersions have been determined by the methods of differential scanning calorimetry (DSC), X-ray diffraction and scanning electron microscopy (SEM). The effect of PEG 6000 on the solubility of selected diclofenac sodium dispersions has been studied. The solubility of diclofenac sodium from its solid dispersion has been found to increase in the presence of PEG 6000.
Poznan University of Medical Sciences, Department of Inorganic and Analytical Chemistry, 6 Grunwaldzka St., 60-780 Poznań, Poland. cbarbara@interia.pl
Barbara
B
Cwiertnia
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004008:Diclofenac / Q000737:chemistry*; D004337:Drug Carriers; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D012997:Solvents; D014867:Water; D004008:Diclofenac; D011092:Polyethylene Glycols