A framework for the co-registration of hemodynamic forces and atherosclerotic plaque components.
Local hemodynamic forces, such as wall shear stress (WSS), are thought to trigger cellular and molecular mechanisms that determine atherosclerotic plaque vulnerability to rupture. Magnetic resonance imaging has emerged as a powerful tool to characterize human carotid atherosclerotic plaque composition and morphology, and to identify plaque features shown to be key determinants of plaque vulnerability. Image-based computational fluid dynamics has allowed researchers to obtain time-resolved WSS information of atherosclerotic carotid arteries. A deeper understanding of the mechanisms of initiation and progression of atherosclerosis can be obtained through the comparison of WSS and plaque composition and morphology. To date, however, advance in knowledge has been limited greatly due to the lack of a reliable infrastructure to perform such analysis. The aim of this study is to establish a framework that will allow for the co-registration and analysis of the three-dimensional distribution of WSS and plaque components and morphology. The use of this framework will lead to future studies targeted to determining the role of WSS in atherosclerotic plaque progression and vulnerability.
Department of Mechanical Engineering, University of Washington, Seattle, WA, USA. gcanton@uw.edu
Gador
G
Canton
Bernard
B
Chiu
Huijun
H
Chen
Yimin
Y
Chen
Thomas S
TS
Hatsukami
William S
WS
Kerwin
Chun
C
Yuan
D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D021621:Imaging, Three-Dimensional; D050356:Lipid Metabolism; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D058226:Plaque, Atherosclerotic / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D012306:Risk; D013314:Stress, Mechanical