Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands.
In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaR-type resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenem-resistant A. baumannii in Asia.
Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Dae Hun
DH
Kim
Ji-Young
JY
Choi
Hae Won
HW
Kim
So Hyun
SH
Kim
Doo Ryeon
DR
Chung
Kyong Ran
KR
Peck
Visanu
V
Thamlikitkul
Thomas Man-Kit
TM
So
Rohani M D
RM
Yasin
Po-Ren
PR
Hsueh
Celia C
CC
Carlos
Li Yang
LY
Hsu
Latre
L
Buntaran
M K
MK
Lalitha
Jae-Hoon
JH
Song
Kwan Soo
KS
Ko
D000151:Acinetobacter Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001208:Asia / Q000453:epidemiology; D015780:Carbapenems / Q000494:pharmacology*; D002999:Clone Cells; D004251:DNA Transposable Elements; D062665:Epidemiological Monitoring; D015870:Gene Expression; D006801:Humans; D010802:Phylogeny; D015995:Prevalence; D018440:beta-Lactam Resistance / Q000187:drug effects / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004251:DNA Transposable Elements; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases