Age-related changes in insula cortical thickness and impulsivity: significance for emotional development and decision-making.
Insula function has been associated with emotional regulation, adjusting to changing outcomes under risk, reward and loss anticipation, discounting of future rewards, and self-rated impulsivity. The role of the insula in these processes may be fundamentally related to prospective thinking, a trait that increases with age. There is evidence that insular cortical thickness shows age related decreases that parallel age related increases in future orientation and planning. We tested the hypothesis that nonplanning decreases with age and that insula thickness is related to both age and nonplanning impulsivity. Fifty-nine male and female participants, ranging in age from 10 to 22 years old, underwent structural magnetic resonance imaging (MRI) procedures and were assessed using the Barratt Impulsiveness Scale (BIS). We observed that anterior insula thickness and nonplanning impulsivity show an inverse relationship with age and that there is a significant positive linear relationship between anterior insula thickness and nonplanning.
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT 84105, USA; The Brain Institute, University of Utah, Salt Lake City, UT 84105, USA. Electronic address: john.churchwell@psych.utah.edu.
John C
JC
Churchwell
Deborah A
DA
Yurgelun-Todd
D000293:Adolescent; D000375:Aging; D002540:Cerebral Cortex / Q000254:growth & development*; D002648:Child; D003657:Decision Making; D004644:Emotions; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D008279:Magnetic Resonance Imaging; D008297:Male; D009473:Neuronal Plasticity; D011340:Problem Solving; D013850:Thinking; D055815:Young Adult
Adolescence; Development; Emotion; Impulsivity; Insula; Planning