Early childhood outcomes of infants born with gastroschisis.
OBJECTIVE
To describe neonatal and childhood outcomes of a contemporary cohort of infants with gastroschisis.


METHODS
Observational, single center, inception cohort of children born with gastroschisis from January 2005 to December 2008.


RESULTS
Of 63 infants, 61 survived to hospital discharge and 39 were seen for follow-up. Complications included sepsis (37%), necrotizing enterocolitis (10%), parenteral nutrition related cholestasis (25%), and short bowel syndrome (13%). Of survivors, 5% had visual impairment and 10% had hearing loss. No child tested had mental delay or cerebral palsy. Early gestational age predicted death or disability (OR 0.60, 95% CI 0.38, 0.96; p=0.033). There was a high incidence of prescription medications for presumed gastroesophageal reflux (90%). Some infants continued to require tube feeds (15%). There were improvements in longitudinal growth reflected in increasing z-scores.


CONCLUSIONS
Although children with gastroschisis are at risk for disability, childhood outcomes are encouraging.
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. michaelv@ualberta.ca
Michael
M
van Manen
Leonora
L
Hendson
Michelle
M
Wiley
Mark
M
Evans
Soreh
S
Taghaddos
Irina
I
Dinu
D000015:Abnormalities, Multiple / Q000453:epidemiology; D002170:Canada / Q000453:epidemiology; D002779:Cholestasis / Q000453:epidemiology / Q000209:etiology; D015897:Comorbidity; D013505:Digestive System Surgical Procedures / Q000706:statistics & numerical data; D020345:Enterocolitis, Necrotizing / Q000453:epidemiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology; D020139:Gastroschisis / Q000453:epidemiology / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000601:surgery; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology; D012678:Sensation Disorders / Q000453:epidemiology; D018805:Sepsis / Q000453:epidemiology; D012778:Short Bowel Syndrome / Q000453:epidemiology; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D016896:Treatment Outcome
Abdomen wall defect; Bayley Scales of Infant and Toddler Development; Bayley-III; CP; FSIQ; Full Scale Intelligence Quotient; Growth; NEC; Neurodevelopment; PN; SD; SNHL; STEP; VI; WPPSI-III; Wechsler Preschool and Primary Scale of Intelligence; cerebral palsy; necrotizing enterocolitis; parenteral nutrition; sensorineural hearing loss; serial transverse enteroplasty procedure; standard deviation; visual impairment