[Plasma osteopontin level and left ventricular remodeling in patients with acute myocardial infarction].
OBJECTIVE
To investigate the change of plasma osteopontin level during the progress of acute ST-segment elevation myocardial infarction, as well as its association with the left ventricular remodeling and prognosis.


METHODS
In the study, 61 patients with acute ST-segment elevation myocardial infarction were recruited. Blood samples were taken at admission, on the 3rd day and 7th day of admission, while 63 healthy blood donors were employed as normal controls. There plasma osteopontin levels were measured by ELSIA.


RESULTS
Compared with the normal controls, the plasma osteopontin levels of the patients with acute ST-segment elevation myocardial infarction were significantly higher at admission [(96.51±37.22) μg/L vs. (54.50±28.17) μ g/L, P<0.001], reached the peak value on the 3rd day, and dropped down on the 7th day. The correlation analysis showed that the plasma osteopontin level positively correlated with age and left ventricular end-systolic volume index 3 months after acute myocardial infarction, and negatively correlated with left ventricular ejection fraction 3 months after acute myocardial infarction. The follow-up study found that the plasma osteopontin level did not predict mortality, re-infarction, stroke, revascularization or hospitalization due to heart failure.


CONCLUSIONS
In patients with acute ST-segment elevation myocardial infarction, the elevated plasma level of osteopontin might be associated with the left ventricular remodeling.
Department of Cardiology, Peking University First Hospital, Beijing 100034, China.
Lei
L
Meng
Jie
J
Wang
Wen-hui
WH
Ding
Ying
Y
Yang
Li-tong
LT
Qi
Yong
Y
Huo
D000208:Acute Disease; D005500:Follow-Up Studies; D006333:Heart Failure; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood* / Q000473:pathology; D053495:Osteopontin / Q000097:blood*; D011379:Prognosis; D013318:Stroke Volume; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
D053495:Osteopontin