Black tea high-molecular-weight polyphenol stimulates exercise training-induced improvement of endurance capacity in mouse via the link between AMPK and GLUT4.
Aerobic exercise can promote "fast-to-slow transition" in skeletal muscles, i.e. an increase in oxidative fibers, mitochondria, and myoglobin and improvement in glucose and lipid metabolism. Here, we found that mice administered Mitochondria Activation Factor (MAF) combined with exercise training could run longer distances and for a longer time compared with the exercise only group; MAF is a high-molecular-weight polyphenol purified from black tea. Furthermore, MAF intake combined with exercise training increased phosphorylation of AMPK and mRNA level of glucose transporter 4 (GLUT4). Thus, our data demonstrate for the first time that MAF activates exercise training-induced intracellular signaling pathways that involve AMPK, and improves endurance capacity.
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Tomoaki
T
Eguchi
Chiaki
C
Kumagai
Takashi
T
Fujihara
Thoru
T
Takemasa
Tetsuo
T
Ozawa
Osamu
O
Numata
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D051275:Glucose Transporter Type 4 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010805:Physical Conditioning, Animal; D010807:Physical Endurance / Q000187:drug effects*; D059808:Polyphenols / Q000008:administration & dosage / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013662:Tea / Q000737:chemistry*
D051275:Glucose Transporter Type 4; D059808:Polyphenols; D012333:RNA, Messenger; D013662:Tea; D055372:AMP-Activated Protein Kinases