I function, therefore I am: overcoming skepticism about mitochondrial supercomplexes.
The mitochondrial respiratory chain is believed to dynamically arrange in suprastructures known as supercomplexes or respirasomes, though their function remains elusive. A recent study in Science (Lapuente-Brun et al., 2013) now reports that dynamic supercomplex assembly determines electron flux from different substrates through the respiratory chain.
Department of Neurology, University of Miami Miller School of Medicine, FL 33136, USA.
Antoni
A
Barrientos
Cristina
C
Ugalde
D000818:Animals; D045304:Cytochromes c / Q000378:metabolism*; D042967:Electron Transport Complex I / Q000378:metabolism*; D014450:Electron Transport Complex III / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D014451:Ubiquinone / Q000378:metabolism*
D014451:Ubiquinone; D045304:Cytochromes c; D003576:Electron Transport Complex IV; D042967:Electron Transport Complex I; D014450:Electron Transport Complex III