Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase.
Gene Center, Department of Biochemistry, Ludwig-Maximilians University Munich, Feodor-Lynen-Strasse 25, 80377 Munich (Germany).
Florian
F
Schlauderer
Katja
K
Lammens
Daniel
D
Nagel
Michelle
M
Vincendeau
Andrea C
AC
Eitelhuber
Steven H L
SH
Verhelst
Dale
D
Kling
Al
A
Chrusciel
Jürgen
J
Ruland
Daniel
D
Krappmann
Karl-Peter
KP
Hopfner
D000494:Allosteric Regulation / Q000187:drug effects; D020169:Caspases / Q000737:chemistry / Q000378:metabolism; D002460:Cell Line; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D010640:Phenothiazines / Q000737:chemistry* / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D009363:Neoplasm Proteins; D010640:Phenothiazines; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
cancer; inhibitors; medicinal chemistry; multiple sclerosis; thioridazine