Lineage specification: reading the instructions may help!
Understanding lineage specification is biologically important and critical for the production of cells for regenerative medicine. Extrinsic cues are clearly necessary but do they direct or select lineage? Single-cell analysis now suggests that cytokine signaling can instruct lineage choice in blood stem cells.
UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK. g.may@ucl.ac.uk
Gill
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May
Tariq
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Enver
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D019070:Cell Lineage / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects*; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D022423:Myeloid Cells / Q000166:cytology* / Q000187:drug effects*
D016173:Macrophage Colony-Stimulating Factor