Acute infection induces a metastatic niche: a double menace for cancer patients.
Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Heath A
HA
Smith
Yibin
Y
Kang
D055371:Acute Lung Injury / Q000235:genetics*; D000818:Animals; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D019718:Receptors, CXCR4 / Q000235:genetics*; D025801:Ubiquitin / Q000235:genetics*
C527276:CXCR4 protein, human; D019718:Receptors, CXCR4; D025801:Ubiquitin