Multilocus sequence typing reveals genetic diversity of carbapenem- or ceftazidime-nonsusceptible Pseudomonas aeruginosa in China.
It is unclear whether the genetic background of drug-resistant Pseudomonas aeruginosa was disseminated from a certain clone. Thus, we performed MLST (multilocus sequence typing) of 896 P. aeruginosa isolates that were nonsusceptible to imipenem, meropenem, or ceftazidime. This revealed 254 sequence types (STs), including 104 new STs and 34 STs with novel alleles. Thirty-three clonal complexes and 404 singletons were found. In conclusion, drug-resistant P. aeruginosa clones can be developed from diverse genetic backgrounds.
Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Jingshu
J
Ji
Jie
J
Wang
Zhihui
Z
Zhou
Haiping
H
Wang
Yan
Y
Jiang
Yunsong
Y
Yu
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use*; D002442:Ceftazidime / Q000627:therapeutic use*; D002681:China / Q000453:epidemiology; D014644:Genetic Variation; D006801:Humans; D058885:Multilocus Sequence Typing; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics*; D018440:beta-Lactam Resistance / Q000187:drug effects / Q000235:genetics
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002442:Ceftazidime