Brain proton magnetic resonance spectroscopy: introduction and overview.
Magnetic resonance (MR) spectroscopy offers a noninvasive means of assessing in vivo brain metabolites that shed light on cellular concentrations, cell function and dysfunction, cellular energetics, presence of ischemia, and presence of necrosis, among others. Studies obtained at higher field strengths are evolving toward sampling of smaller tissue volumes, greater signal-to-noise ratio, and higher metabolic spatial resolution. This article discusses the usefulness, from the clinical standpoint, of MR spectroscopy in various disorders. However, to be valid and significant the results of MR spectroscopy should always be correlated with their imaging counterparts.
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Débora
D
Bertholdo
Arvemas
A
Watcharakorn
Mauricio
M
Castillo
D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D001704:Biopolymers / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D001927:Brain Diseases / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009656:North America; D011522:Protons
D015415:Biomarkers; D001704:Biopolymers; D011522:Protons
(1)H Magnetic resonance spectroscopy; Brain metabolites; Brain tumors; Stimulated echo acquisition mode