Making no bones about it: Transcription factors in vertebrate skeletogenesis and disease.
Skeletogenesis is a complex multi-step process, which involves many genes and pathways. The tightly regulated interplay between these genes in these pathways ensures a correct and timely organogenesis and it is imperative that we have a fair understanding of the major genes and gene families involved in the process. This review aims to give a deeper insight into the roles of 3 major transcription factor families involved in skeleton formation:Sox, RunxandPaxand to look at the human skeleotogenic phenotypes associated with mutations in these genes.
Stem Cell and Developmental Biology, Genome Institute of Singapore, 60 Biopolis Street, 138672, Singapore.
Sumantra
S
Chatterjee
V
V
Sivakamasundari
Wenqing Jean
WJ
Lee
Hsiao Yun
HY
Chan
Thomas
T
Lufkin
Pax; Runx; Sox; microRNAs; skeletogenesis