Iatrogenic acute pancreatitis due to hypercalcemia in a child with pseudohypoparathyroidism.
Pancreatitis due to hypercalcemia is very rare in children, and its pathogenetic role is still debated. The following report describes a case of acute pancreatitis secondary to hypercalcemia in a 6-year-old boy with pseudohypoparathyroidism treated with calcium and vitamin D. Pseudohypoparathyroidism is characterized by parathormone (PTH) resistance, high PTH levels and hypocalcemia which need to be corrected with calcium and vitamin D supplementation. The patient was admitted for severe abdominal pain and vomiting associated with high plasma amylase, lipase and calcium levels. Hypercalcemia due to vitamin D and calcium overtreatment was probably responsible for the acute pancreatitis in this case. High serum calcium levels seem to sensitize patients to pancreatitis, even if the mechanism through which it happens is not completely understood. Moreover, the importance of concomitant predisposing factors, either acquired or especially genetic, needs to be further defined. Even though a rare occurance in childhood, hypercalcemia should be considered as a cause of pancreatitis and it should be examined together with the other etiologies that may contribute to the development of this disease.
Francesca
F
Feyles
Alessandro
A
Mussa
Valentina
V
Peiretti
Daniele
D
Tessaris
Arianna
A
Santanera
Andrea
A
Corrias
Luisa
L
de Sanctis
Luigi
L
Calvo
D000208:Acute Disease; D002118:Calcium / Q000627:therapeutic use; D002648:Child; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D007049:Iatrogenic Disease; D008297:Male; D010195:Pancreatitis / Q000209:etiology; D011547:Pseudohypoparathyroidism / Q000150:complications* / Q000188:drug therapy; D014807:Vitamin D / Q000627:therapeutic use
D014807:Vitamin D; D002118:Calcium