[Expressions of CMTM8 and E-cadherin in primary and metastatic clear cell renal cell carcinoma].
OBJECTIVE
To investigate the expression and clinical pathological significance of CMTM8 and E-cadherin in primary and metastatic clear-cell renal cell carcinoma.


METHODS
The immunohistochemistry was used to detect the expressions of CMTM8 and E-cadherin in 17 cases of primary clear-cell renal cell carcinoma, 8 cases of normal renal tissue, 9 cases of metastatic renal cell carcinoma in lungs and 10 cases of metastatic renal cell carcinoma in bones.


RESULTS
The membranous staining intensities of CMTM8 and E-cadherin in normal renal tissue were strong, but reduced in low-grade clear-cell renal cell carcinoma. There were positive cytoplasmic stainings of CMTM8 and E-cadherin in high-grade clear-cell renal cell carcinoma. Increased cytoplasmic expression of CMTM8 was frequent in metastatic renal cell carcinoma, accompanied with reduced cell surface staining. The expression of E-cadherin could be negative or weakly positive at membrane and cytoplasma. CMTM8 and E-cadherin expressions were negatively correlated with development and metastasis in clear-cell renal cell carcinoma (r=-0.841 and r=-0.732, P<0.001). Moreover, CMTM8 was also correlated with the expression of E-cadherin (r=0.694, P<0.001).


CONCLUSIONS
CMTM8 and E-cadherin are negatively correlated with tumorgenesis and development in clear-cell renal cell carcinoma. The location and intensity of their expressions have significant association with the prognosis.
Department of Urology, Peking University People's Hospital, Beijing 100044, China.
Hao
H
Hu
Jing-wen
JW
Chen
Ke-xin
KX
Xu
Dong
D
Wang
Ying
Y
Wang
Gong-wei
GW
Wang
Shi-ying
SY
Zhang
Xiao-feng
XF
Wang
D015703:Antigens, CD; D001859:Bone Neoplasms / Q000378:metabolism / Q000556:secondary; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology; D018925:Chemokines / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary; D062792:MARVEL Domain-Containing Proteins / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis
D015703:Antigens, CD; C513384:CDH1 protein, human; C507076:CMTM8 protein, human; D015820:Cadherins; D018925:Chemokines; D062792:MARVEL Domain-Containing Proteins