Applicability of standard parameters in diagnostics of primary open-angle glaucoma.
BACKGROUND
The aim of this study was to evaluate the sensitivity, specificity, and likelihood ratio of standard diagnostic parameters C/D, NFI, and MD and their applicability in diagnostics of primary open-angle glaucoma.


METHODS
This study included 194 subjects (371 eyes), ages 30 to 65 years old, who underwent full ophthalmologic examination and HRT, GDx, and FDT examinations. The values of C/D, NFI, and MD diagnostic parameters were determined. The data were statistically evaluated to determine their sensitivity, specificity, and likelihood ratio.


RESULTS
Values of the positive and negative likelihood ratios were C/D (11.471 and 0.159), NFI (3.739 and 0.152), and MD (6.323 and 0.309), respectively.


CONCLUSIONS
The C/D parameter showed the highest sensitivity and specificity, as well as high positive likelihood ratio and near-zero negative likelihood ratio. The NFI and MD parameters showed lower likelihood ratios and their applicability for the diagnosis of primary open-angle glaucoma is limited.
Clinic of Ophthalmology, Medical Center of Postgraduate Education, Wrasaw, Poland.
Barbara
B
Polaczek-Krupa
Iwona
I
Grabska-Liberek
D000328:Adult; D000368:Aged; D003941:Diagnostic Techniques, Ophthalmological / Q000592:standards*; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D016013:Likelihood Functions; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D012015:Reference Standards; D012160:Retina / Q000473:pathology; D012680:Sensitivity and Specificity