Organizing the HIV vaccine development effort.
OBJECTIVE
To describe and compare the diverse organizational structures and funding mechanisms applied to advance HIV preventive vaccine research and development and to help explain and inform evolving infrastructures and collaborative funding models.


RESULTS
On the basis of models that have been tried, improved or abandoned over three decades, the field seems to have settled into a relatively stable set of diverse initiatives, each with its own organizational signature. At the same time, this set of organizations is forging cross-organizational collaborations, which promise to acquire newly emergent beneficial properties.


CONCLUSIONS
Strong motivation to expedite HIV vaccine R&D has driven a diversity of customized and inventive organizational approaches, largely government and foundation funded. Although no one approach has proven a panacea, the field has evolved into a constellation of often overlapping organizations that complement or reinforce one another. The Global HIV Vaccine Enterprise, a responsive, rapidly evolving loose infrastructure, is an innovative collaboration to catalyze that evolution.
Global HIV Vaccine Enterprise, New York, New York 10004, USA.
Yegor
Y
Voronin
William
W
Snow
D016915:AIDS Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D000818:Animals; D035843:Biomedical Research / Q000191:economics* / Q000458:organization & administration*; D002202:Capital Financing / Q000458:organization & administration; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control*; D006801:Humans
D016915:AIDS Vaccines