Inflammation and cancer stem cells.
Cancer stem cells are becoming recognised as being responsible for metastasis and treatment resistance. The complex cellular and molecular network that regulates cancer stem cells and the role that inflammation plays in cancer progression are slowly being elucidated. Cytokines, secreted by tumour associated immune cells, activate the necessary pathways required by cancer stem cells to facilitate cancer stem cells progressing through the epithelial-mesenchymal transition and migrating to distant sites. Once in situ, these cancer stem cells can secrete their own attractants, thus providing an environment whereby these cells can continue to propagate the tumour in a secondary niche.
School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia. Electronic address: sarah.shigdar@deakin.edu.au.
Sarah
S
Shigdar
Cancer Care Centre, St. George Hospital, and St. George Clinical School, Faculty of Medicine, University of New South Wales, Kensington, NSW 2052, Australia.
Yong
Y
Li
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.
Santanu
S
Bhattacharya
School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
Michael
M
O'Connor
Dalian Sixth People's Hospital, Dalian 116033, China.
Chunwen
C
Pu
School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
Jia
J
Lin
School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
Tao
T
Wang
School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
Dongxi
D
Xiang
School of Medical Science and Griffith Health Institute, Griffith University, Gold Coast Campus, Southport, Australia.
Lingxue
L
Kong
Institute for Frontier Materials, Deakin University, Waurn Ponds, Victoria, Australia.
Ming Q
MQ
Wei
Suzhou Key Laboratory of Nanobiomedicine, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu, China.
Yimin
Y
Zhu
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA.
Shufeng
S
Zhou
School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia. Electronic address: wduan@deakin.edu.au.
Wei
W
Duan
D000818:Animals; D002471:Cell Transformation, Neoplastic; D044127:Epigenesis, Genetic; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D055153:Stem Cell Niche; D059016:Tumor Microenvironment
D018836:Inflammation Mediators
Cancer stem cells; Epigenetics; Epithelial–mesenchymal transition; Inflammation; Microenvironment