HLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression.
We looked at our HIV + slow progressors cohort to determine if there were any human leukocyte antigen (HLA) correlates for protection. No statistically significant allelic differences were found between the HIV + and control cohorts using regression analysis, though trends were noted. Data for Elite Controllers showed an increased frequency of B*57. Likewise, no correlation was inferred with the clinical data of the HIV + cohort. We hypothesize that the protective effect of HLA alleles may have been lost over time.
aNuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK bBeijing You'An Hospital, Capital Medical University, Beijing, China cCentre for Statistics in Medicine, Oxford, UK dSchool of Public Health, Sun Yat-sen University, Guangzhou, China eMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK fBeijing Ditan Hospital, Capital Medical University, Beijing, China. *Marie-E. Blais and Ke Yi Xu contributed equally to the writing of this article.
Mohammad A
MA
Rai
Yonghong
Y
Zhang
Louis-M
LM
Yindom
Jane
J
Holmes
Ly-Mee
LM
Yu
Chun
C
Hao
Tim
T
Rostron
Huiping
H
Yan
Yong Li
YL
Zhang
Chao
C
Cai
Andrew J
AJ
McMichael
Tao
T
Dong
Sarah L
SL
Rowland-Jones
Marie-E
ME
Blais
Ke Yi
KY
Xu
D002681:China; D015331:Cohort Studies; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology*; D020276:HIV Long-Term Survivors; D006801:Humans; D010750:Phosphoproteins / Q000235:genetics*
C574674:La protein, human; D010750:Phosphoproteins