Echocardiographically measured epicardial fat predicts restenosis after coronary stenting.
OBJECTIVE
Epicardial adipose tissue (EAT), deposited around subepicardial coronary vessels, may contribute directly to perivascular inflammation and smooth muscle cell proliferation. This study assessed the relationship between EAT and in-stent restenosis.


METHODS
Four hundred and seven patients had received successful coronary intervention. EAT thickness was measured by echocardiography. Angiographic follow-up was obtained between 6 months and 2 years. Restenosis was defined as target lesion revascularization (TLR). EAT thickness of patients was compared by TLR controlling for additional well-known predictors of restenosis. The TLR-free survival analysis according to EAT thickness was estimated using the Kaplan-Meier method and the differences between groups were assessed by the log-rank test.


RESULTS
Median EAT thickness was significantly increased in patients undergoing TLR compared with those without restenosis (3.7 vs. 3.0 mm, p = 0.001). EAT thickness was one of the independent factors associated with restenosis (Odds ratio = 1.19, 95% confidence interval = 1.01-1.33, p = 0.007). The TLR-free survival of patients with thick EAT was significantly worse than patients with thin EAT (log-rank p = 0.001).


CONCLUSIONS
EAT thickness is related with restenosis and may provide additional information for future restenosis.
Department of Cardiology, Ajou University School of Medicine , Suwon , Korea.
Jin-Sun
JS
Park
Byoung-Joo
BJ
Choi
So-Yeon
SY
Choi
Myeong-Ho
MH
Yoon
Gyo-Seung
GS
Hwang
Seung-Jea
SJ
Tahk
Joon-Han
JH
Shin
D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D050154:Adiposity; D000368:Aged; D023903:Coronary Restenosis / Q000209:etiology*; D004452:Echocardiography; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology; D015607:Stents / Q000009:adverse effects