Comparative proteomics lends insight into genotype-specific pathogenicity.
Comparative proteomic analyses have emerged as a powerful tool for the identification of unique biomarkers and mechanisms of pathogenesis. In this issue of Proteomics, Murugaiyan et al. utilize difference gel electrophoresis (DIGE) to examine differential protein expression between nonpathogenic and pathogenic genotypes of Prototheca zopfii, a causative agent in bovine enteritis and mastitis. Their findings provide insights into molecular mechanisms of infection and evolutionary adaptation of pathogenic genotypes, demonstrating the power of comparative proteomic analyses.
National Renewable Energy Laboratory, National Bioenergy Center, Golden, CO, USA.
Michael T
MT
Guarnieri
D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional / Q000662:veterinary*; D005260:Female; D008414:Mastitis, Bovine / Q000209:etiology*; D010940:Plant Proteins / Q000032:analysis*; D020543:Proteome / Q000737:chemistry*; D011525:Prototheca / Q000235:genetics* / Q000378:metabolism*
D010940:Plant Proteins; D020543:Proteome
Algae; Comparative proteomics; Pathogenesis; Plant proteomics