15-Lipoxygenases in cancer: a double-edged sword?
Among the lipoxygenases, a diverse family of fatty acid dioxygenases with varying tissue-specific expression, 15-lipoxygenase (15-LOX) was found to be involved in many aspects of human cancer, such as angiogenesis, chronic inflammation, metastasis formation, and direct and indirect tumor suppression. Herein, evidence for the expression and action of 15-LOX and its orthologs in various neoplasms, including solid tumors and hematologic malignancies, is reviewed. The debate surrounding the impact of 15-LOX as either a tumor-promoting or a tumor-suppressing enzyme is highlighted and discussed in the context of its role in other biological systems.
Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, P.O. Box 9602, Haifa 31096, Israel.
Adi J
AJ
Klil-Drori
Amiram
A
Ariel
D000818:Animals; D001093:Arachidonate 15-Lipoxygenase / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology*
D001093:Arachidonate 15-Lipoxygenase
Arachidonic acid; Docosahexaenoic acid; Lipoxygenase; Neoplastic growth; Tumor biology