Metabolic phenotyping of diabetic nephropathy.
Diabetic nephropathy is the most serious complication of type 1 diabetes. There is no treatment to protect the kidneys from poorly controlled diabetes, and therefore prevention of the initial metabolic insults is currently the only effective approach to reducing the high mortality related to diabetic nephropathy. Metabolic phenotyping brings us one step closer to understanding the unique set of regulatory perturbations that predispose to kidney injury and paves the way for multiparametric risk assessment.
1] Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, USA [2] Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland [3] Folkhälsan Institute of Genetics, Biomedicum Helsinki, Helsinki, Finland.
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Mäkinen
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Kangas
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Soininen
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Würtz
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Groop
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Ala-Korpela
D015415:Biomarkers / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000097:blood / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010641:Phenotype; D018570:Risk Assessment
D015415:Biomarkers