Myxoid liposarcoma with cartilaginous differentiation: A case study with fish analysis and review of the literature.
Cartilaginous differentiation is rarely encountered in myxoid liposarcomas. To date, a small number of such cases have been described, and molecular or cytogenetic analysis was performed only in few of them. In the present study, we describe a primary myxoid liposarcoma with cartilaginous differentiation which arised in the left thigh of a 37-year-old man. Miscroscopically, the tumor consisted of areas with typical myxoid liposarcoma morphology and areas of sharply demarcated hyaline cartilage nodules. Here, we present the results of Fluorescence In Situ Hybridization (FISH) analysis that revealed the presence of FUS and DDIT3 gene rearrangements in both the liposarcomatous and cartilaginous components of the tumor. These findings confirm the neoplastic nature of the cartilage component in this rare tumor.
Department of Pathology, University of Thessaly, School of Medicine, Biopolis, Larissa 41110, Greece. Electronic address: mioan@med.uth.gr.
Maria G
MG
Ioannou
Evangelos
E
Kouvaras
Rodoula
R
Papamichali
Theophilos
T
Karachalios
George
G
Koukoulis
D000328:Adult; D002356:Cartilage / Q000473:pathology*; D002454:Cell Differentiation; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018208:Liposarcoma, Myxoid / Q000235:genetics* / Q000473:pathology*; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology*; D013848:Thigh / Q000473:pathology
C532377:FUS-DDIT3 fusion protein, human; D015514:Oncogene Proteins, Fusion
Cartilaginous; Fluorescence in situ hybridization; Myxoid liposarcoma; Pathology