Three new polyketides from marine-derived fungus Aspergillus glaucus HB1-19.
Two new benzyl derivatives, aspergentisyl A (1) and aspergentisyl B (2), as well as one new naphthoquinone derivative, aspergiodiquinone (3), together with seven known prenylated benzaldehyde derivatives (4-10) were isolated from the marine-derived fungus Aspergillus glaucus HB1-19. The structures of these compounds were characterized based on 1D and 2D NMR spectra analyses and comparison with those reported in the literature. In addition, each isolate was tested for its 1,1-diphenyl-2-picrylhydrazyl radical-scavenging property and all these compounds except compound 3 exhibited strong radical-scavenging activity.
a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , 266003 , China.
Shi-Wei
SW
Sun
Chang-Zhu
CZ
Ji
Qian-Qun
QQ
Gu
De-Hai
DH
Li
Tian-Jiao
TJ
Zhu
D001230:Aspergillus / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D001593:Benzyl Compounds; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D009285:Naphthoquinones; D010851:Picrates; D061065:Polyketides; C585694:aspergentisyl A; C585696:aspergentisyl B; C585695:aspergiodiquinone; C004931:1,1-diphenyl-2-picrylhydrazyl