Butyrylcholinesterase and γ-glutamyltransferase activities and oxidative stress markers are altered in metabolic syndrome, but are not affected by body mass index.
Metabolic syndrome (MetS) leads to changes in enzymatic activities, oxidative and inflammatory parameters. Adenosine deaminase (ADA), dipeptidyl peptidase IV (DPP-IV), butyrylcholinesterase (BuChE) and γ-glutamyltransferase (γ-GT) activities, C-reactive protein (hsCRP) and nitric oxide levels (NOx), as well as oxidative stress markers were analyzed in 39 subjects with MetS and 48 controls. Also, the influence of body mass index (BMI) and anthropometric measurements were evaluated. Disturbances in antioxidant defenses and higher γ-GT and BuChE activities, NOx and hsCRP levels were observed in subjects with MetS. These findings remained associated with MetS after adjustment for BMI, except for hsCRP. ADA was correlated with age, insulin levels and HOMA-IR index in MetS. DPP-IV and total cholesterol (TC), BuChE activity and TC, and VIT C and hsCRP levels also were correlated. The analyzed parameters may reflect the inflammatory state of the MetS, and could contribute to prevention and control of various aspects of this syndrome.
Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil.
Karine S
KS
De Bona
Gabriela
G
Bonfanti
Paula E R
PE
Bitencourt
Lariane O
LO
Cargnelutti
Priscila S
PS
da Silva
Leidiane
L
De Lucca
Victor C
VC
Pimentel
Etiane
E
Tatsch
Thissiane L
TL
Gonçalves
Melissa
M
Premaor
Rafael N
RN
Moresco
Maria Beatriz
MB
Moretto
D000243:Adenosine Deaminase / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D015992:Body Mass Index; D002091:Butyrylcholinesterase / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008297:Male; D024821:Metabolic Syndrome / Q000201:enzymology* / Q000378:metabolism*; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000276:immunology*; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D015415:Biomarkers; D009569:Nitric Oxide; D002097:C-Reactive Protein; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D002091:Butyrylcholinesterase; D018819:Dipeptidyl Peptidase 4; D000243:Adenosine Deaminase