Pathogenesis of type 2 diabetes in South Asians.
The risk of developing type 2 diabetes mellitus (T2DM) is exceptionally high among both native and migrant South Asians. T2DM occurs more often and at a younger age and lower BMI, and the risk of coronary artery and cerebrovascular disease, and renal complications is higher for South Asians compared with people of White Caucasian descent. The high prevalence of T2DM and its related complications in South Asians, which comprise one-fifth of the total world's population, poses a major health and socioeconomic burden. The underlying cause of this excess risk, however, is still not completely understood. Therefore, gaining insight into the pathogenesis of T2DM in South Asians is of great importance. The predominant mechanism, in this ethnicity seems to be insulin resistance (IR) rather than an impaired β-cell function. In this systematic review, we describe several possible mechanisms that may underlie or contribute to the increased IR observed in South Asians.
Department of General Internal Medicine and Endocrinology Walaeus Library, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Leontine E H
LE
Bakker
Maria A
MA
Sleddering
Jan W
JW
Schoones
A Edo
AE
Meinders
Ingrid M
IM
Jazet
D000273:Adipose Tissue / Q000503:physiopathology; D044466:Asian People / Q000706:statistics & numerical data*; D005075:Biological Evolution; D001823:Body Composition / Q000502:physiology; D008076:Cholesterol, HDL / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics; D004032:Diet; D015444:Exercise; D006801:Humans; D008019:Life Style; D018482:Muscle, Skeletal / Q000503:physiopathology; D009569:Nitric Oxide / Q000378:metabolism; D044465:White People
D008076:Cholesterol, HDL; D009569:Nitric Oxide