Tissue-compliant neural implants from microfabricated carbon nanotube multilayer composite.
Current neural prosthetic devices (NPDs) induce chronic inflammation due to complex mechanical and biological reactions related, in part, to staggering discrepancies of mechanical properties with neural tissue. Relatively large size of the implants and traumas to blood-brain barrier contribute to inflammation reactions, as well. Mitigation of these problems and the realization of long-term brain interface require a new generation of NPDs fabricated from flexible materials compliant with the brain tissue. However, such materials will need to display hard-to-combine mechanical and electrical properties which are not available in the toolbox of classical neurotechnology. Moreover, these new materials will concomitantly demand different methods of (a) device micromanufacturing and (b) surgical implantation in brains because currently used processes take advantage of high stiffness of the devices. Carbon nanotubes (CNTs) serve as a promising foundation for such materials because of their record mechanical and electrical properties, but CNT-based tissue-compliant devices have not been realized yet. In this study, we formalize the mechanical requirements to tissue-compliant implants based on critical rupture strength of brain tissue and demonstrate that miniature CNT-based devices can satisfy these requirements. We fabricated them using MEMS-like technology and miniaturized them so that at least two dimensions of the electrodes would be comparable to brain tissue cells. The nanocomposite-based flexible neural electrodes were implanted into the rat motor cortex using a surgical procedure specifically designed for soft tissue-compliant implants. The post-surgery implant localization in the motor cortex was successfully visualized with magnetic resonance and photoacoustic imaging. In vivo functionality was demonstrated by successful registration of the low-frequency neural recording in the live brain of anesthetized rats. Investigation of inflammation processes around these electrodes will be required to establish their prospects as long-term neural electrodes.
Department of Chemical Engineering, ‡Department of Biomedical Engineering, §Department of Radiology, ⊥Department of Materials Science, and ∥Biointerface Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.
Huanan
H
Zhang
Paras R
PR
Patel
Zhixing
Z
Xie
Scott D
SD
Swanson
Xueding
X
Wang
Nicholas A
NA
Kotov
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000633:toxicity; D055119:Elastic Modulus; D017097:Electric Impedance; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006244:Hardness; D008297:Male; D008422:Materials Testing; D008839:Microelectrodes; D008904:Miniaturization; D009044:Motor Cortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D013718:Tensile Strength
D001672:Biocompatible Materials; D037742:Nanotubes, Carbon