Association study on the DLG4 gene and schizophrenia in the Chinese Han population.
BACKGROUND
Abnormal expressions of the N-methyl-D-aspartate receptor and its interacting postsynaptic density (PSD) molecules have been hypothesized to be involved in the pathophysiology of schizophrenia. Few studies have carried out association studies with DLG4 gene (coding PSD-95 protein) and sought to validate the results with Asian schizophrenia patients.


METHODS
To further investigate the significance of DLG4 in Asian schizophrenic patients, we examined seven single-nucleotide polymorphisms (SNPs) within this gene in 1504 unrelated Chinese mainland individuals (893 patients and 611 controls).


RESULTS
No association was found between these seven SNPs and schizophrenia within our sample. No significant differences in allele or genotype frequencies between schizophrenic paranoid patients and controls were found.


CONCLUSIONS
Although no allelic or genotypic variances of this gene were observed, the possibility that SNPs within DLG4 represent a positive schizophrenia risk gene cannot be excluded. Our research provided a reference for further research into this gene in other populations.
aKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University bInstitutes of Biomedical Sciences, Fudan University cInstitute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences dShanghai Institute of Mental Health, Shanghai, China.
Xing-wang
XW
Li
Bao-cheng
BC
Liu
Yang
Y
Wang
Qing-zhu
QZ
Zhao
Qi
Q
Shen
Tao
T
Yu
Shi-qing
SQ
Chen
Feng-ping
FP
Yang
Wei-dong
WD
Li
Ling-han
LH
Gao
Yi-feng
YF
Xu
Guo-yin
GY
Feng
Lin
L
He
Guang
G
He
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D000076122:Disks Large Homolog 4 Protein; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
C501444:DLG4 protein, human; D000076122:Disks Large Homolog 4 Protein; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins