Cinchonine and thiourea.
In this viewpoint, we discuss the seminal work contributed by Dixon, who reported the first use of a bifunctional cinchona-derived thiourea organocatalyst for the enantioselective conjugate addition of malonate esters to nitroalkenes. Since then, this class of catalysts has been extensively utilized in a variety of fundamental transformations. We also highlight here some of the representative studies performed since the publication of this milestone work in 2005.
C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26505, USA. Xiaodong.Shi@mail.wvu.edu.
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