Changes in plasma Brain-derived neurotrophic factor (BDNF) levels induced by methylphenidate in children with Attention deficit-hyperactivity disorder (ADHD).
OBJECTIVE
It has been suggested that BDNF may play a role in the pathogenesis of ADHD. Our aim is to determine whether methylphenidate can induce changes in plasma BDNF levels of children with ADHD.


METHODS
We assessed levels of plasma BDNF in 28 ADHD patients (age range = 3.5-10 years) before and after 6 weeks treatment with effective dosages of methylphenidate. Then we evaluated the correlation of levels of plasma BDNF with clinical variables, especially ADHD Conner's parents rating scale.


RESULTS
According to the paired sample T-test, the mean plasma BDNF level in the baseline was 193.06 pg/ml, whereas 271.06 pg/ml in the end point, thus showing significantly higher mean plasma BDNF levels in the post-treatment situation than in the pretreatment (t = -3.393, df = 27, p = 0.002). Pearson's correlation test revealed that there was also significant negative correlation between levels of BDNF in the plasma of ADHD patients before treatment and improvement in hyperactivity symptoms with treatment (Pearson's correlation = -0.395, p = 0.037).


CONCLUSIONS
The mean plasma BDNF levels increased after 6 weeks of treatment with methylphenidate. Also, we found an improvement in hyperactivity symptoms with decreasing baseline plasma BDNF levels. We recommend that more studies should be conducted in order to assess the possible roles of plasma BDNF levels in treatment response prediction and prognosis.
Department of Psychiatry, Shafa Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Ali
A
Amiri
Gholamreza
G
Torabi Parizi
Maryam
M
Kousha
Farshid
F
Saadat
Mohammad-Jafar
MJ
Modabbernia
Kiomars
K
Najafi
Zahra
Z
Atrkar Roushan
D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales
D019208:Brain-Derived Neurotrophic Factor; D000697:Central Nervous System Stimulants; D008774:Methylphenidate
ADHD; BDNF; Methylphenidate; Plasma