Plasmapheresis and immunoadsorption for treatment and prophylaxis of recurrent focal segmental glomerulosclerosis in adult recipients of deceased donor renal grafts.
Recurrent focal segmental glomerulosclerosis has a great impact on kidney graft survival. This retrospective study presents immunoadsorption-plasmapheresis treatment and outcome in our renal graft recipients with significant post-transplant proteinuria (>1 g/day) and focal segmental glomerulosclerosis in native kidneys. Recurrence was defined as occurrence of nephrotic range proteinuria or biopsy-confirmed diagnosis. Successful treatment was defined as sustained reduction of proteinuria to <1 g/day. From 2000 through 2011, 548 adult patients received kidney grafts from deceased donors. In 20 of these patients (3.6%) end-stage renal disease was a consequence of focal segmental glomerulosclerosis. Recurrence was confirmed in five of seven treated patients. Immunoadsorption-plasmapheresis treatment was successful in five patients (70%). Their age at disease diagnosis in native kidneys was 12 to 44 years. Time to end-stage renal disease was 3 to 14 years. Recipient age at transplantation was 21 to 61 years. Onset of significant proteinuria was 2 to 87 days after transplantation. Immunoadsorption or plasmapheresis started 1 to 7 days after recurrence of significant proteinuria. Treatment period was 1 to 103 months and 12 to 206 procedures were performed per patient. Follow-up period after cessation of plasmapheresis was 11 to 58 months. Final urine protein/creatinine ratio was 8.8 to 98.0 mg/mmol and final serum creatinine was 63 to 148 μmol/L. Follow-up after transplantation was 18 to 135 months. One patient was still on treatment. One graft was lost to recurrence. No serious adverse effects occurred during immunoadsorption and plasmapheresis. Immunoadsorption and plasmapheresis appears to be successful in the majority of patients, probably due to their early start.
Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia. aljosa.kandus@guest.arnes.si
Aljoša
A
Kandus
Rafael
R
Ponikvar
Jadranka
J
Buturović-Ponikvar
Andrej F
AF
Bren
Manca
M
Oblak
Gregor
G
Mlinšek
Andrej
A
Kmetec
Miha
M
Arnol
D000328:Adult; D005500:Follow-Up Studies; D005923:Glomerulosclerosis, Focal Segmental / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D007163:Immunosorbent Techniques; D016030:Kidney Transplantation; D008875:Middle Aged; D010956:Plasmapheresis / Q000379:methods*; D011507:Proteinuria / Q000209:etiology; D012189:Retrospective Studies; D055502:Secondary Prevention; D013997:Time Factors; D014019:Tissue Donors; D055815:Young Adult
Focal segmental glomerulosclerosis; Immunoadsorption; Plasmapheresis; Proteinuria; Renal transplantation