Comparison between cold plasma, electrochemotherapy and combined therapy in a melanoma mouse model.
The study was undertaken to compare antitumor efficacy of electrochemotherapy (ECT) with cold plasma therapy (CP) in a melanoma mouse model. After melanoma implantation into the flank of C57BL/6N mice, CP by two different plasma sources (APPJ and DBD) was applied directly to the tumor surface. ECT was performed with bleomycin intravenously at a field strength of 1000 V/cm without or combined with CP. Primary endpoints were tumor growth acceleration (TGA), daily volume progression (DVP) and survival after treatment. Both plasma sources as single treatment showed a significant TGA delay, which proved less effective than ECT. CP (APPJ) combined with ECT (ECJ) significantly improved per cent mouse survival, with significant superiority compared with ECT. Plasma therapy alone albeit less effective seems a potential alternative to ECT in patients with melanoma and can be applied manifold in a session without general anaesthesia. Accordingly, CP alone and combined with ECT may serve as new option in palliative skin melanoma therapy.
Department of Dermatology, University of Greifswald, Greifswald, Germany. georg.daeschlein@uni-greifswald.de
Georg
G
Daeschlein
Sebastian
S
Scholz
Stine
S
Lutze
Andreas
A
Arnold
Sebastian
S
von Podewils
Thomas
T
Kiefer
Thomas
T
Tueting
Olaf
O
Hardt
Hermann
H
Haase
Olaf
O
Grisk
Sönke
S
Langner
Christoph
C
Ritter
Thomas
T
von Woedtke
Michael
M
Jünger
D000818:Animals; D003131:Combined Modality Therapy; D053672:Electrochemotherapy; D005260:Female; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D058626:Plasma Gases / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
D058626:Plasma Gases
cold plasma; cutaneous melanoma; electrochemotherapy; mouse model; plasma medicine