Mechanisms and mechanics of cell competition in epithelia.
When fast-growing cells are confronted with slow-growing cells in a mosaic tissue, the slow-growing cells are often progressively eliminated by apoptosis through a process known as cell competition. The underlying signalling pathways remain unknown, but recent findings have shown that cell crowding within an epithelium leads to the eviction of cells from the epithelial sheet. This suggests that mechanical forces could contribute to cell elimination during cell competition.
Medical Research Council (MRC) National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. jvincen@nimr.mrc.ac.uk
Jean-Paul
JP
Vincent
Alexander G
AG
Fletcher
L Alberto
LA
Baena-Lopez
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D013314:Stress, Mechanical; D013312:Stress, Physiological