[Study on intestinal absorption kinetics of apigenin in rats].
To establish an in situ single-way intestinal perfusion model, in order to study the intestinal absorption kinetics of AP. The concentration of AP in the perfusate was determined by HLPC. The results showed different AP concentrations in all intestinal segments, with the fastest absorption rate in duodenum, which was followed by jejunum, ileum and colon. In general, the constant absorption rate (Ka) of AP in duodenum and jejunum first increased and then decreased with the rise in drug concentration (P <0. 05); the absorption mechanism may be related to active transport and facilitated diffusion factors. The constant absorption rate (Ka) of AP in ileum and colon generally kept unchanged with the rise diffusion in drug concentration, the absorption mechanism may be related to passive.
China Pharmaceutical University, Nanjing 210009, China. hechenghua1987@163.com
Cheng-Hua
CH
He
Zhen-Hai
ZH
Zhang
Shu
S
Wang
Jian-Ping
JP
Zhou
Hui-Xia
HX
Lv
D000818:Animals; D047310:Apigenin / Q000378:metabolism*; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D051381:Rats
D047310:Apigenin