Daytime sleepiness is associated with falls in Parkinson's disease.
Falls are frequent in Parkinson's disease (PD), and may be influenced by daytime sleepiness. We reviewed the records of 120 men with PD. Mean Epworth Sleepiness Scale (ESS) values were significantly different between non-fallers and fallers (6.0 vs. 9.7, p < 0.01). In multivariate analysis, ESS remained significantly associated with falls (OR 1.2, 95% CI 1.1-1.4, p = 0.02), along with cognitive impairment (OR 4.4 95% CI 1.0-18.7, p = 0.04) and postural instability/gait dysfunction (OR 1.6 95% CI 1.0-2.4, p = 0.03) in non-depressed patients. In conclusion, non-depressed PD patients are 20% more likely to fall for every one unit increase in the ESS measure of sleepiness.
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Parkinson's Disease Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA.
Meredith
M
Spindler
Nalaka S
NS
Gooneratne
Andrew
A
Siderowf
John E
JE
Duda
Charles
C
Cantor
Nabila
N
Dahodwala
D000058:Accidental Falls / Q000706:statistics & numerical data*; D000368:Aged; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology; D003627:Data Interpretation, Statistical; D003863:Depression / Q000523:psychology; D006970:Disorders of Excessive Somnolence / Q000150:complications*; D005684:Gait / Q000502:physiology; D020233:Gait Disorders, Neurologic; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010300:Parkinson Disease / Q000150:complications*; D011187:Posture / Q000502:physiology; D011569:Psychiatric Status Rating Scales