[Progress in InDel as a new generation of genetic marker].
As forensic DNA typing experienced three generations of genetic marker researching stage, short tandem repeat (STR) has been widely used in forensic identification as a mature tool. Further exploration of the human genome led to the discovery of polymorphism markers of single nucleotide polymorphism (SNP) and Insertion/Deletion (InDel). InDel, which combines the desirable characteristics of previous genetic markers as a new type of genetic marker, has got extensive concern in fields like medical molecular biology and forensic biology. This paper generally reviews the history of research and the corresponding results of InDel along the line of time axis as well as the different aims of these research focusing on the progress in the multiple amplification system with several InDel as the genetic marker (autosomal or X chromosome) in forensic biology and anthropology. Finally, the direction of research in this field and the problems to be solved have been put forward.
Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China. sunkuan9@gmail.com
Kuan
K
Sun
Su-Hua
SH
Zhang
Ru-Xin
RX
Zhu
Shu-Min
SM
Zhao
Cheng-Tao
CT
Li
D041321:Chromosomes, Human, X / Q000235:genetics; D004247:DNA / Q000032:analysis / Q000235:genetics; D016172:DNA Fingerprinting / Q000379:methods*; D053803:Forensic Genetics / Q000379:methods*; D005819:Genetic Markers; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies
D005819:Genetic Markers; D004247:DNA