Evaluation ofHelicobacter pylorieradication and drug therapy in patients with functional dyspepsia.
The aim of this study was to assess the effect ofHelicobactor pylori (H. pylori)infection and drug therapy on functional dyspepsia (FD) symptoms and gastrointestinal eosinophil count. In this study, 215 continuous FD patients fulfilling Rome III criteria were enrolled. The patients were divided into aH. pylori-positive group and aH. pylori-negative group. TheH. pylori-positive group was divided intoH. pylori-eradicated andH. pylori-uneradicated groups followingH. pylori-eradication treatment, and theH. pylori-negative group was randomly divided into esomeprazole and teprenone treatment groups. The symptom scores of the esomeprazole group were significantly lower compared with those of the teprenone group at week 6 but not at baseline and week 2. Compared with theH. pylori-uneradicated group, eosinophil counts in the antrum and body were significantly reduced in theH. pylori-eradicated group at week 6. The number of gastric eosinophil clusters was significantly higher in theH. pylori-positive group than in theH. pylori-negative group. Eradication was associated with gastric eosinophil counts but did not affect duodenal eosinophil levels. Neither esomeprazole nor teprenone treatments reduced eosinophil levels in the stomach and duodenum ofH. pylori-negative patients.
Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong 250012; ; Departments of Gastroenterology, Shandong 255400, P.R. China.
Weidong
W
Zhao
Xiaoqin
X
Zhong
Xinying
X
Zhuang
Hongmei
H
Ji
Xinxin
X
Li
Anqing
A
Li
Ruicai
R
Wang
Jianyou
J
Zhu
Yanqing
Y
Li
Helicobacter pylori; eosinophils; functional dyspepsia; symptom improvement