Incremental value of adenosine stress cardiac magnetic resonance in coronary artery disease detection.
BACKGROUND
Cardiac magnetic resonance myocardial perfusion imaging (CMR-MPI) is considered a state-of-the-art non-invasive modality for ischemia detection but its additive value in a multiple-test strategy in patients with suspected coronary artery disease (CAD) is not fully validated. We aimed to evaluate CMR-MPI integration with exercise treadmill test (ETT) for the diagnostic workup of patients with suspected CAD, having invasive fractional flow reserve (FFR) as reference standard.


METHODS
In this prospective single-center study, patients with suspected CAD underwent sequential ETT, CMR-MPI and X-ray invasive coronary angiography (XA). Significant CAD was defined by the presence of stenosis >40% with FFR ≤ 0.8 in vessels >2 mm or ≥90% stenosis/occlusion.


RESULTS
80 symptomatic patients (68% male, 61 ± 8 years) were enrolled. Compared to ETT, CMR-MPI showed similar sensitivity (81%) and higher specificity (93 vs. 58%, p < 0.001) for CAD detection (prevalence = 46%) translating into better diagnostic performance (AUC 0.87 vs. 0.70; p = 0.002). CMR-MPI improved accuracy independently of ETT in all patients with high pre-test probability and in intermediate-probability patients but those with a clearly positive-ETT (symptoms + ST-shift), in whom ETT correctly identified CAD. In the low-probability group CMR-MPI was useful as a gatekeeper for XA after a positive-ETT. The best integrating protocol achieved a global accuracy of 89% (AUC 0.88) and was clearly superior to an approach based solely in ETT (AUC 0.70, p < 0.001), yet similar to isolated CMR-MPI (AUC 0.87, p = ns).


CONCLUSIONS
CMR-MPI has high sensitivity and specificity for CAD detection and may be combined with ETT in a diagnostic workflow aiming to increase accuracy and reduce the number of unnecessary catheterizations.
Cardiology Department, Centro Hospitalar de Gaia/Espinho, Portugal. Electronic address: eulaliaalvespereira@gmail.com.
Eulália
E
Pereira
Nuno
N
Bettencourt
Nuno
N
Ferreira
Andreas
A
Schuster
Amedeo
A
Chiribiri
João
J
Primo
Madalena
M
Teixeira
Lino
L
Simões
Adelino
A
Leite-Moreira
José
J
Silva-Cardoso
Vasco
V
Gama
Eike
E
Nagel
D000241:Adenosine; D000368:Aged; D017023:Coronary Angiography / Q000639:trends*; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000639:trends*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000241:Adenosine
Adenosine stress cardiac magnetic resonance; Coronary artery disease; Exercise treadmill test; Invasive fractional flow reserve; Pretest probability of coronary artery disease; X-ray coronary angiography