Central nervous system and head and neck imaging findings of MYC/BCL2 "double hit" B cell lymphoma.
MYC/BCL2 double hit lymphoma (DHL) is a rare, recently recognised and highly aggressive subtype of non-Hodgkin lymphoma, with an affinity to involve the central nervous system and the head and neck either at initial presentation or during relapse. We present a case of 43-year-old woman with MYC/BCL2 DHL relapse in the nasopharynx with extensive spread to the neck, skull base, and the central nervous system. To our knowledge, this is the first reported case in the literature describing the MRI and CT scan findings and the profound pattern of disease involvement of this rare neoplasm.
Neurological Intervention and Imaging Service of Western Australia (NIISwa), 1st Floor G Block, Sir Charles Gairdner Hospitals, Hospital Avenue, Nedlands, WA 6009, Australia. Electronic address: ziyadlk@hotmail.com.
Ziyad L
ZL
Khaleel
Department of Haematology, Royal Perth Hospital, Perth, WA, Australia.
Mathew P
MP
Wright
Department of Radiology, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
Edward
E
Quigley
Neurological Intervention and Imaging Service of Western Australia (NIISwa), 1st Floor G Block, Sir Charles Gairdner Hospitals, Hospital Avenue, Nedlands, WA 6009, Australia.
T J
TJ
Singh
Neurological Intervention and Imaging Service of Western Australia (NIISwa), 1st Floor G Block, Sir Charles Gairdner Hospitals, Hospital Avenue, Nedlands, WA 6009, Australia.
Randall
R
Jones
D000328:Adult; D017809:Fatal Outcome; D005260:Female; D019254:Genes, bcl-2; D016259:Genes, myc; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D009305:Nasopharynx / Q000000981:diagnostic imaging / Q000473:pathology; D009333:Neck / Q000000981:diagnostic imaging / Q000473:pathology; D019291:Skull Base / Q000000981:diagnostic imaging / Q000473:pathology; D019292:Skull Base Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D014057:Tomography, X-Ray Computed
Central nervous system; Central skull base; Head; MYC/BCL2 double hit lymphoma; Nasopharynx; Neck; Non-Hodgkin lymphoma