Mitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum.
Mitochondrial dysfunction is often associated with increased reactive oxygen species (ROS) production by the organelle itself. Leadsham et al. (2013) now show that the link between mitochondrial damage and ROS is more complicated, at least in yeast, where signals from damaged mitochondria increase ROS production from the endoplasmic reticulum surface.
MRC Mitochondrial Biology Unit, Cambridge, UK. mpm@mrc-mbu.cam.ac.uk
Michael P
MP
Murphy
D030401:Cytochrome-c Oxidase Deficiency / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D018631:ras Proteins / Q000378:metabolism*
D017382:Reactive Oxygen Species; D003576:Electron Transport Complex IV; D018631:ras Proteins