Apgar score after induction of anesthesia for canine cesarean section with alfaxalone versus propofol.
The effects of alfaxalone and propofol on neonatal vitality were studied in 22 bitches and 81 puppies after their use as anesthetic induction agents for emergency cesarean section. After assessment that surgery was indicated, bitches were randomly allocated to receive alfaxalone 1 to 2 mg/kg body weight or propofol 2 to 6 mg/kg body weight for anesthetic induction. Both drugs were administered intravenously to effect to allow endotracheal intubation, and anesthesia was maintained with isoflurane in oxygen. Neonatal vitality was assessed using a modified Apgar score that took into account heart rate, respiratory effort, reflex irritability, motility, and mucous membrane color (maximum score = 10); scores were assigned at 5, 15, and 60 minutes after delivery. Neither the number of puppies delivered nor the proportion of surviving puppies up to 3 months after delivery differed between groups. Anesthetic induction drug and time of scoring were associated with the Apgar score, but delivery time was not. Apgar scores in the alfaxalone group were greater than those in the propofol group at 5, 15, and 60 minutes after delivery; the overall estimated score difference between the groups was 3.3 (confidence interval 95%: 1.6-4.9; P < 0.001). In conclusion, both alfaxalone and propofol can be safely used for induction of anesthesia in bitches undergoing emergency cesarean section. Although puppy survival was similar after the use of these drugs, alfaxalone was associated with better neonatal vitality during the first 60 minutes after delivery.
Unit of Small Animal Reproduction, Clinic for Reproductive Medicine, University of Zurich, Zurich, Switzerland.
A
A
Doebeli
E
E
Michel
R
R
Bettschart
S
S
Hartnack
I M
IM
Reichler
D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002585:Cesarean Section / Q000662:veterinary; D004285:Dogs; D005260:Female; D011247:Pregnancy; D011277:Pregnanediones / Q000009:adverse effects* / Q000627:therapeutic use; D015742:Propofol / Q000009:adverse effects* / Q000627:therapeutic use
D011277:Pregnanediones; C006477:alphaxalone; D015742:Propofol
Alfaxalone; Apgar score; Canine; Cesarean section; Propofol; Puppy