Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform.
We developed a new building block for a protein- and cell-repellant self-assembled monolayer (SAM) from 2-methacryloyloxyethyl phosphorylcholine (MPC) via a simple Michael-type addition to one mercapto group in alkanedithiol. The thiolated MPC can enable functionalization of a noble metal electrode to minimize noise signal in biosensing.
Institute of Biomaterial and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan. goda.bsr@tmd.ac.jp miyahara.bsr@tmd.ac.jp.
Tatsuro
T
Goda
Miyuki
M
Tabata
Mai
M
Sanjoh
Mai
M
Uchimura
Yasuhiko
Y
Iwasaki
Yuji
Y
Miyahara
D015374:Biosensing Techniques / Q000295:instrumentation*; D002448:Cell Adhesion; D004566:Electrodes; D004867:Equipment Design; D006046:Gold / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D008689:Methacrylates / Q000737:chemistry*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry
D008689:Methacrylates; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine; D006046:Gold