Synthesis of antimicrobial peptoids.
Peptoids (N-substituted glycines) are mimics of α-peptides in which the side chains are attached to the backbone N (α) -amide nitrogen instead of the C (α) -atom. Peptoids hold promise as therapeutics since they often retain the biological activity of the parent peptide and are stable to proteases. In recent years, peptoids have attracted attention as new potential antibiotics against multiresistant bacteria. Here we describe the submonomer solid-phase synthesis of an antimicrobial peptoid, H-Nmbn-Nlys-Nlys-Nnap-Nbut-Nmbn-Nlys-NH2.
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Paul R
PR
Hansen
Jens K
JK
Munk
D000596:Amino Acids / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D005449:Fluorenes / Q000737:chemistry; D034444:Peptoids / Q000138:chemical synthesis*; D012117:Resins, Synthetic / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*
D000596:Amino Acids; D000890:Anti-Infective Agents; D005449:Fluorenes; D034444:Peptoids; D012117:Resins, Synthetic