Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh City, Vietnam, 2011.
Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formulate vaccination policy in Vietnam.
Children's Hospital No. 1, Ho Chi Minh City, Vietnam.
Le Phan Kim
le PK
Thoa
Pai-Shan
PS
Chiang
Truong Huu
TH
Khanh
Shu-Ting
ST
Luo
Tran Ngoc Hanh
TN
Dan
Ya-Fang
YF
Wang
Tang Chi
TC
Thuong
Wan-Yu
WY
Chung
Nguyen Thanh
NT
Hung
Jen-Ren
JR
Wang
Le Nguyen Thanh
le NT
Nhan
Le Quoc
le Q
Thinh
Ih-Jen
IJ
Su
Than Duc
TD
Dung
Min-Shi
MS
Lee
D000956:Antigens, Viral / Q000235:genetics* / Q000276:immunology*; D004770:Enterovirus / Q000145:classification / Q000235:genetics*; D004769:Enterovirus Infections / Q000821:virology; D006801:Humans; D010802:Phylogeny; D014744:Vietnam
D000956:Antigens, Viral