Mild cognitive impairment in Parkinson's disease: a review of current concepts.
Mild Cognitive Impairment in Parkinson's Disease (PD-MCI) is common and may be associated with accelerated progression to dementia. Considering the importance of this emerging entity, new diagnostic criteria have recently been proposed. Early recognition and accurate classification of PD-MCI could offer opportunities for novel therapeutic interventions. This review discusses current definitions for PD-MCI, the screening tools used, the pattern of cognitive deficits observed, and the predictors of cognitive decline and transition to Parkinson's Disease Dementia. Emerging biomarkers, which may aid diagnosis, are also explored and the role of novel treatment options is considered.
Parkinson's Disease Research Clinic, Brain & Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia.
Natalie C
NC
Palavra
Sharon L
SL
Naismith
Simon J G
SJ
Lewis