Correlation between spirometry values and pulmonary artery pressure in young healthy subjects.
BACKGROUND
Pulmonary hypertension is frequently associated with parenchymal lung disease. We evaluated the association between spirometry values and pulmonary artery systolic pressure (PASP) in young subjects without lung disease


METHODS
: We studied applicants to the Israeli Air Force, who undergo routine evaluation that includes resting spirometry and echocardiography. Applicants with overt lung disease were excluded. All echocardiographic studies performed in the years 1994 through 2010 (n = 6,598) were screened, and files that included PASP and spirometry values were analyzed for the association between PASP and FVC, FEV1, FEV1/FVC, peak expiratory flow, and forced expiratory flow during the middle half of the FVC maneuver.


RESULTS
Of the 647 air force applicants who underwent echocardiography in which PASP was measurable and had spirometry data, 607 (94%) were male, and their average age was 18.16 ± 0.73 years. Mean PASP was 26.4 ± 5.2 mm Hg (range 10-41 mm Hg). None of the spirometry values significantly correlated with PASP.


CONCLUSIONS
PASP in young healthy subjects is not significantly associated with spirometry values. Lung mechanics probably do not contribute significantly to PASP in this population.
Israeli Air Force Aero Medical Center, Tel Hashomer, Israel.
Alon
A
Grossman
Michal
M
Benderly
Alex
A
Prokupetz
Barak
B
Gordon
Ofra
O
Kalter-Leibovici
D000293:Adolescent; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008889:Military Personnel; D011651:Pulmonary Artery / Q000502:physiology*; D012129:Respiratory Function Tests; D013147:Spirometry; D013599:Systole
pulmonary hypertension; screening; spirometry