[Comparative study on toxicity of extracts from Phytolaccae Radix before and after being processed with vinegar].
OBJECTIVE
To extract and separate toxic components from Phytolaccae Radix, and to comare the changes in toxicity of Phytolaccae Radix before and after being processed with vinegar.


METHODS
The mucous membrane irritation response, mouse peritoneal inflammation model and in vitro macrophages release NO model were applied to compared the changes in inflammatory toxicity of toxic components from Phytolaccae Radix before and after being processed with vinegar.


RESULTS
Toxic components of Phytolacca Radix had significant inflammatory toxicity, which could cause conjunctival edema in rabbits, and increase of PGE2 and macrophages release NO content in peritoneal exudate in mice. After being processed with vinegar, they showed reduced irritation, which resulted in decrease of PGE2 and macrophages release NO content in peritoneal exudate in mice.


CONCLUSIONS
After being processed with vinegar, the toxicity of toxic components from Phytolacca Radix decreased obviously.
Pharmacology College of Nanjing University of Chinese Medicine, Nanjing 210029, China. gongle2010@163.com
Le
L
Gong
Hao
H
Wu
Hong-Li
HL
Yu
Teng-Fei
TF
Zhao
Qiu-Xiang
QX
Xu
D019342:Acetic Acid / Q000737:chemistry; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification* / Q000633:toxicity*; D005123:Eye / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D029603:Phytolacca / Q000737:chemistry*; D011817:Rabbits
D004365:Drugs, Chinese Herbal; D019342:Acetic Acid