[Antitumor mechanism of metformin via adenosine monophosphate-activated protein kinase (AMPK) activation].
Metformin, as a traditional oral hypoglycemic agent, is commonly used in the clinical treatment for type 2 diabetes. Recently, a large number of epidemiological researches have shown that metformin could reduce the tumor morbidity of type 2 diabetes, moreover, it has also been indicated that metformin could inhibit the growth, proliferation and transformation of cancer cells in metabolic pathways, cell cycle, oxidative stress and cancer/tumor stem cells transformation via AMPK pathway activation. But the antitumor effect of metformin via AMPK activation still exists arguments, and the definite mechanism remains to be further investigated and confirmed by extensive clinical trials.
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Zhaoyu
Z
Chen
Liantang
L
Wang
Yanyang
Y
Chen
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D008687:Metformin / Q000494:pharmacology*; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents; D008687:Metformin; D055372:AMP-Activated Protein Kinases