Surface stress-based biosensors.
Surface stress-based biosensors, as one kind of label-free biosensors, have attracted lots of attention in the process of information gathering and measurement for the biological, chemical and medical application with the development of technology and society. This kind of biosensors offers many advantages such as short response time (less than milliseconds) and a typical sensitivity at nanogram, picoliter, femtojoule and attomolar level. Furthermore, it simplifies sample preparation and testing procedures. In this work, progress made towards the use of surface stress-based biosensors for achieving better performance is critically reviewed, including our recent achievement, the optimally circular membrane-based biosensors and biosensor array. The further scientific and technological challenges in this field are also summarized. Critical remark and future steps towards the ultimate surface stress-based biosensors are addressed.
MicroNano System Research Center, Taiyuan University of Technology, Taiyuan, Shanxi 030024, People's Republic of China; Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, Taiyuan University of Technology, Taiyuan, Shanxi 030024, People's Republic of China.
Shengbo
S
Sang
Yuan
Y
Zhao
Wendong
W
Zhang
Pengwei
P
Li
Jie
J
Hu
Gang
G
Li
D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006801:Humans; D056656:Lab-On-A-Chip Devices; D055595:Mechanical Phenomena; D013499:Surface Properties
Biosensors; Microcantilever; Micromembrane; Signal detection.; Surface stress