Effect of binder liquid type on spherical crystallization.
OBJECTIVE
Spherical crystallization is a process of formation of agglomerates of crystals held together by binder liquid. This research focused on understanding the effect of type of solvents used as binder liquid on the agglomeration of crystals.


METHODS
Carbamazepine and ethanol/water were used respectively as a model drug and crystallization system. Eight solvents as binder liquid including chloroform, dichloromethane, isopropyl acetate, ethyl acetate, n-hexane, dimethyl aniline, benzene and toluene were examined to better understand the relationship between the physical properties of the binder liquid and its ability to bring about the formation of the agglomerates. Moreover, the agglomerates obtained from effective solvents as binder liquid were evaluated in term of size, apparent particle density and compressive strength.


RESULTS
In this study the clear trend was observed experimentally in the agglomerate formation as a function of physical properties of the binder liquid such as miscibility with crystallization system. Furthermore, the properties of obtained agglomerates such as size, apparent particle density and compressive strength were directly related to physical properties of effective binder liquids.


CONCLUSIONS
RESULTS of this study offer a useful starting point for a conceptual framework to guide the selection of solvent systems for spherical crystallization.
School of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Maryam
M
Maghsoodi
Ali
A
Hajipour
D002220:Carbamazepine / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization / Q000379:methods*; D005079:Excipients / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013499:Surface Properties
D005079:Excipients; D012997:Solvents; D002220:Carbamazepine
Binder liquid; carbamazepine; spherical crystallization