Inflammasome and atherogenesis.
Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune cells in the arterial wall. Inflammation and the innate immune response are involved in the formation of early atherosclerotic lesion. A protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are responsible for activation of inflammatory processes. Inflammasome-mediated processes are important in the process of atherosclerosis. The front of structure domains as well as IL-1, and IL-18 stands at the threshold of the adaptive immune response that accelerates full-blown atherosclerotic disease progression. This review is intended to provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for therapy of this disease.
Xinjie
X
Lu
Thrombosis Research Institute, London, SW3 6LR. xlu@tri-london.ac.uk.
Vijay
V
Kakkar
D050197:Atherosclerosis / Q000378:metabolism / Q000503:physiopathology*; D001343:Autophagy; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism / Q000502:physiology*; D008264:Macrophages / Q000276:immunology; D008958:Models, Molecular; D015394:Molecular Structure; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism
D058847:Inflammasomes; D018160:Receptors, Cytoplasmic and Nuclear