Identification of a FXIIIA variant in human neuroblastoma cell lines.
FXIII is a transglutaminase consisting of two catalytic (FXIIIA) and two non-catalytic subunits (FXIIIB) in plasma, where this enzyme is responsible for stabilizing fibrin clots. Although possible functions of intracellular FXIIIA have been proposed, these remain to be established. We show that a 40 kDa protein species of FXIIIA is present in the human neuroblastoma cell lines SH-SY5Y and LAN5. These data reveal the presence of a new uncharacterised variant of FXIIIA, possibly due to an alternative splicing, in nervous cells.
Department of Biochemistry, Biophysics and General Pathology, Second University of Naples 80138 Naples, Italy.
Martina
M
lannaccone
Gaia
G
Giuberti
Giulia
G
De Vivo
Michele
M
Caraglia
Vittorio
V
Gentile
CNS; Transglutaminases; cellular factor XIII; post-translational modifications of proteins