Predictors of recovery in first episode psychosis: the OPUS cohort at 10 year follow-up.
BACKGROUND
Recovery, the optimal goal in treatment, is the attainment of both symptomatic and functional remission over a sustained period of time. Identification of factors that promote recovery can help develop interventions that facilitate good outcomes for people with first episode psychosis.


OBJECTIVE
To examine long-term outcomes within a cohort of people with first episode psychosis in relation to symptom remission, functioning and recovery, 10 years after diagnosis.


METHODS
The study had a prospective design. Participants from the OPUS trial (1998-2000) (n=496) completed a series of interviews and questionnaires to measure current levels of psychopathology and social/vocational functioning, ten years after diagnosis. Predictors of recovery were identified using socio-demographic and clinical characteristics collected at baseline.


RESULTS
A total of 304 participants were interviewed, giving a follow-up rate of 61%. A total of 42 people (14%) met the criteria for symptomatic and psychosocial recovery at 10 years. A multivariable binary logistic regression analysis indicated that baseline predictors accounted for 22% of the variance of full recovery. Lower severity of negative symptoms at baseline (Odds Ratio (OR) 0.53, 95% confidence interval CI 0.36-0.78, p<0.001) and earlier age of diagnosis (OR 0.92, 95% CI 0.86-0.99, p<0.05) predicted better rates of recovery at 10 years.


CONCLUSIONS
Results of this study indicated that negative symptoms could play a central role in the process of recovery from schizophrenia. A challenge for clinicians and researchers is to understand the mechanisms behind negative symptoms and develop interventions that can prevent or ameliorate these symptoms in order to promote recovery.
Center for Psychiatric Research, Aarhus University, Denmark; Psychiatric Center Copenhagen, University of Copenhagen, Denmark. Electronic address: stepaust@rm.dk.
Stephen F
SF
Austin
Ole
O
Mors
Rikke Gry
RG
Secher
Carsten R
CR
Hjorthøj
Nikolai
N
Albert
Mette
M
Bertelsen
Heidi
H
Jensen
Pia
P
Jeppesen
Lone
L
Petersen
Lasse
L
Randers
Anne
A
Thorup
Merete
M
Nordentoft
D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007326:Institutionalization; D007406:Interview, Psychological; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000503:physiopathology* / Q000523:psychology*; D020127:Recovery of Function / Q000502:physiology*; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D013997:Time Factors; D055815:Young Adult
First episode psychosis; Long-term prognosis; Recovery; Schizophrenia