Different cytotoxicities and cellular localizations of novel quindoline derivatives with or without boronic acid modifications in cancer cells.
The synthesis of a 4 × 4 series of novel quindoline derivatives with or without boronic acid modifications and their cytotoxicities, cellular localizations, and implications on cancer cells are presented and discussed.
School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, China. jiangtao@ouc.edu.cn lijuanzhang@ouc.edu.cn.
Ruijuan
R
Yin
Meng
M
Zhang
Cui
C
Hao
Wei
W
Wang
Peiju
P
Qiu
Shengbiao
S
Wan
Lijuan
L
Zhang
Tao
T
Jiang
D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001897:Boronic Acids / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000970:Antineoplastic Agents; D001897:Boronic Acids; D007211:Indoles; D011804:Quinolines; C016712:quindoline