Imipramine-induced c-Fos expression in the medial prefrontal cortex is decreased in the ACTH-treated rats.
Previous studies have shown that the antidepressive-like effect of tricyclic antidepressants is blocked by repeated treatments with adrenocorticotropic hormone (ACTH). However, little is known about the neuroanatomy underlying the mechanism of the imipramine treatment-resistant depression model. In the present study, first experimental evidence showed no significant difference of the serum imipramine concentrations between the saline and ACTH-treated rats. In further study, imipramine produced significant increases in the c-Fos expression in the medial prefrontal cortex (mPFC), the dentate gyrus of the hippocampus (DGH), and the central nucleus of the amygdala (CeA), in rats repeatedly treated with saline. The imipramine-increased c-Fos immunoreactivity was suppressed in the mPFC of rats repeatedly treated with ACTH. However, there was no significant difference in c-Fos expression in the DGH and CeA between ACTH- and saline-treated rats. These results suggest that the mPFC is maybe involved in effects of the imipramine in the ACTH-treated rats.
School of Life Science, Northeast Normal University, Changchun, 130024, People's Republic of China; Division of Hospital Pharmacy, Ehime University Medical School, Ehime, 791-0295, Japan.
Bingjin
B
Li
Katsuya
K
Suemaru
Yoshihisa
Y
Kitamura
Yutaka
Y
Gomita
Hiroaki
H
Araki
Ranji
R
Cui
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage; D000679:Amygdala / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000009:adverse effects; D018891:Dentate Gyrus / Q000187:drug effects / Q000378:metabolism; D003863:Depression / Q000188:drug therapy* / Q000473:pathology; D005786:Gene Expression Regulation / Q000187:drug effects; D007099:Imipramine / Q000008:administration & dosage*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats
D000929:Antidepressive Agents, Tricyclic; D016760:Proto-Oncogene Proteins c-fos; D000324:Adrenocorticotropic Hormone; D007099:Imipramine
Cell, c-Fos; Depression; Medial Prefrontal cCrtex