Modification of a cyclo-olefin surface by radio-sterilization: is there any effect on the interaction with drug solutions?
A cyclo-olefin copolymer was subjected to an e-beam ionizing treatment. Two doses were studied: one corresponding to the recommended dose for the sterilization of pharmaceutical packaging (25 kGy), and a greater one to enhance the modifications caused by the treatment (150 kGy). The surface modifications were studied by X-ray photoelectron spectroscopy (XPS), contact angle measurements and atomic force microscopy (AFM). The roughness and the wettability of the surface were enhanced by the treatment. The consequences of the surface modifications on the drug interaction with the polymer were studied.
Université Paris-Sud, EA 401, IFR 141, Faculté de pharmacie, F-92296 Châtenay Malabry, France.
Hala
H
Barakat
Johanna
J
Saunier
Caroline
C
Aymes Chodur
Pascal
P
Aubert
Jackie
J
Vigneron
Arnaud
A
Etcheberry
Najet
N
Yagoubi
D001548:Benzalkonium Compounds / Q000737:chemistry*; D004349:Drug Packaging; D005030:Ethylenes / Q000737:chemistry; D007545:Isoproterenol / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D009636:Norbornanes / Q000737:chemistry; D010656:Phenylephrine / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000737:chemistry / Q000528:radiation effects*; D011839:Radiation, Ionizing; D012996:Solutions; D013242:Sterilization / Q000379:methods*; D013499:Surface Properties; D017155:Wettability
D001548:Benzalkonium Compounds; D005030:Ethylenes; D009636:Norbornanes; D011108:Polymers; D012996:Solutions; D010656:Phenylephrine; C046060:2-norbornene; C036216:ethylene; D007545:Isoproterenol
Contact angle; Cyclo-olefin; Drug interaction; E-beam sterilization; Oxidation; Surface