Dextran-based self-healing hydrogels formed by reversible diels-alder reaction under physiological conditions.
A dextran-based self-healing hydrogel is prepared by reversible Diels-Alder reaction under physiological conditions. Cytocompatible fulvene-modified dextran as main polymer chains and dichloromaleic-acid-modified poly(ethylene glycol) as cross-linkers are used. Both macro- and microscopic observation as well as the rheological recovery test confirm the self-healing property of the dextran-l-poly(ethylene glycol) hydrogels ("l" means "linked-by"). In addition, scanning electrochemical microscopy is used to qualitatively and quantitatively in situ track the self-healing process of the hydrogel for the first time. It is found that the longitudinal depth of scratch on hydrogel surface almost completely healed at 37 °C after 7 h. This work represents a facile approach for fabrication of polysaccharide self-healing hydrogel, which can be potentially used in several biomedical fields.
Department of Chemistry, School of Science, MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an, 710049, P.R. China; Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, P.R. China.
Zhao
Z
Wei
Jian Hai
JH
Yang
Xiao Jing
XJ
Du
Feng
F
Xu
Miklos
M
Zrinyi
Yoshihito
Y
Osada
Fei
F
Li
Yong Mei
YM
Chen
D061565:Cycloaddition Reaction; D003911:Dextrans / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry; D012212:Rheology
D003911:Dextrans; D020100:Hydrogels; D011108:Polymers; D011134:Polysaccharides; D011092:Polyethylene Glycols
dextran; hydrogels; self-healing