Effect of intraoperative manipulation during iris-claw phakic IOL implantation on endothelium.
OBJECTIVE
To evaluate the effect of intraoperative complications during iris-claw phakic intraocular lens (pIOL) implantation on endothelial cell survival.


METHODS
Retrospective cohort study.


METHODS
Fifty-two eyes of 26 patients with high myopia treated with the iris-claw pIOL.


METHODS
The patients were divided as group 1 (no intraoperative events) and 2 (intraoperative events) according to the intraoperative events such as intraoperative bleeding, postoperative intraocular pressure (IOP) rise, and late resolution of the chamber inflammation. Endothelial cell density was compared at 1, 2, 6, 12, and 24 months after the operation prospectively.


RESULTS
Group 1 showed mean percentage of individual change of -0.04%±7.90% at 1 month, -0.01%±8.67% at 2 months, -0.02%±10.33% at 6 months, 0.05%±9.81% at 12 months, and 0.05%±5.33% at 24 months postoperatively. In group 2, mean percentage individual cell change was -0.17%±8.57% at 1 month, -0.13%±12.14% at 2 months, -0.13%±15.07% at 6 months, -0.17%±11.94% at 12 months, and -0.28%±13.54% at 24 months postoperatively. Two groups showed a significant differences in every visit.


CONCLUSIONS
Even transient events, such as intraoperative bleeding, postoperative IOP rise, and late resolution of the chamber inflammation, would affect the survival of endothelial cells.
Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kyung-Sun
KS
Na
Sohee
S
Jeon
Choun-Ki
CK
Joo
D000328:Adult; D002470:Cell Survival; D015331:Cohort Studies; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis / Q000209:etiology*; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D007431:Intraoperative Complications; D007498:Iris / Q000601:surgery*; D019654:Lens Implantation, Intraocular / Q000379:methods; D008297:Male; D047728:Myopia, Degenerative / Q000503:physiopathology / Q000601:surgery*; D054120:Phakic Intraocular Lenses; D011183:Postoperative Complications; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult