[The metabolic abnormalities in plaques of multiple sclerosis patients - the assessment in proton MR spectroscopy (1HMRS)].
The aim of the study was the assessment of metabolic changes revealed in proton MR spectroscopy in plaques of white matter of MS patients. With the use of MR 1.5T system, 90 MS patients were performed single voxel spectroscopy (SVS) of 1HMRS, divided in 3 groups: 20 CIS form, 50 RR form, 20 SP form. Absolute levels of NAA (N-acetylaspartate), Cr (creati. ne), Cho (choline), mI (mio-lnositol), Lip (lipids), Lac (lactate) and ratios of NAA/Cr, Cho/Cr, ml/Cr, Lip/Cr and Lac/Cr obtained from lesions, were calculated. Statistically significant changes were obtained in lesions: decrease of NAA/Cr ratio and increase of Cho/Cr ratio were observed in all patients gro ups. In RR, SP forms increase of ml/Cr ratio and in CIS form increase of Lip/Cr and Lac/Cr ratios were detected. The metabolic abnormalities in plaques of white matter in MS patients may be detected using 1HMRS.
Katedra Radiologii, Uniwersytet Jagielloński, Collegium Medicum.
Malgorzata
M
Szafirska
Andrzej
A
Urbanik
Teresa
T
Róg
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001369:Axons / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D056784:Leukoencephalopathies / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline