Improved chiral SFC screening for analytical method development.
In this study we describe the evaluation of a recently developed supercritical fluid chromatography (SFC) instrument for automated chiral SFC method development. The greatly improved gradient dwell volume and liquid flow control of the new instrument in combination with the use of shorter columns containing smaller stationary phase particles affords chiral SFC method development that is faster and more universal than previous systems.
Analytical Chemistry, Merck Research Laboratories, Rahway, New Jersey.
Wes
W
Schafer
Tilak
T
Chandrasekaran
Zainab
Z
Pirzada
Chaowei
C
Zhang
Xiaoyi
X
Gong
Mirlinda
M
Biba
Erik L
EL
Regalado
Christopher J
CJ
Welch
D002845:Chromatography / Q000379:methods*; D013237:Stereoisomerism; D013267:Stilbenes / Q000737:chemistry
D013267:Stilbenes; C025906:stilbene oxide
SFC; chiral screening; fast analysis; method development