Catalytic stereospecific alkylation of malononitriles with enantioenriched primary allylic amines.
An unprecedented alkylation reaction of malononitriles with enantioenriched primary allylic amines has been developed in a stereospecific manner through palladium-catalyzed sp(3) C-N bond cleavage without additives at room temperature.
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
Man-Bo
MB
Li
Hao
H
Li
Ju
J
Wang
Cong-Rong
CR
Liu
Shi-Kai
SK
Tian
D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
D000588:Amines; D009570:Nitriles; D010165:Palladium; C000945:dicyanmethane