Copper(II)-catalyzed trifluoromethylation of N-aryl imines.
Methods for imine trifluoromethylation are of great importance because amines with trifluoromethylated stereogenic centers are useful building blocks for synthetic chemistry and drug discovery. Herein, we describe a new copper(II)-catalyzed imine trifluoromethylation method without the use of Lewis base activators, presumably through cooperative activation.
Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.
Yong-Qiang
YQ
Zhang
Ji-Dan
JD
Liu
Hao
H
Xu
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
D007097:Imines; D005461:Fluorine; D003300:Copper