[Antidotes in clinical toxicology].
This overview describes antidotes, and their clinical pharmacology, that have an established significance in the currently practiced clinical toxicology because of their proven effectiveness in the treatment of serious poisonings. For the proper, efficient, and targeted use of an antidote, pharmacological knowledge is required, which is a central subject of this article. Current data from the literature are used as reference along with the accumulated experiences about possible adverse effects in order to include them in therapeutic considerations. The dosage of antidotes is the subject of several other review articles and is therefore not included in this synopsis.
Vergiftungsinformationszentrale, Gesundheit Österreich GmbH, Stubenring 6, 1010, Wien, Österreich, karl.hruby@meduniwien.ac.at.
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Hruby
D000931:Antidotes / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use; D006801:Humans; D011041:Poisoning / Q000097:blood / Q000188:drug therapy*; D055553:Prescription Drugs / Q000493:pharmacokinetics / Q000506:poisoning; D066007:Toxicokinetics
D000931:Antidotes; D005217:Fat Emulsions, Intravenous; D055553:Prescription Drugs