Caught in the act.
The crystal structure of a HECT E3 enzyme has been captured as it transfers ubiquitin to a target protein, revealing the dramatic changes in shape that enable it to modify particular residues in its targets.
is in the Department of Molecular and Cell Biology , University of California, Berkeley , Berkeley , United States hermannmeyer@berkeley.edu.
Hermann-Josef
HJ
Meyer
Michael
M
Rape
D008239:Lysine / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D008239:Lysine
E2 conjugating enzyme; E3 ligase; HECT; NEDD4; Rsp5; S. cerevisiae; ubiquitin