Stem cell therapy for bone regeneration: present and future strategies.
Alveolar bone atrophy may occur due to trauma, malignancy and periodontal disease. Restoring the lost bone is crucial for the rehabilitation of the patient's functioning, phonetics and aesthetics. Currently the methods available for vertical bone augmentation prior to dental implant placement are rather limited. This paper describes present and future concepts of utilizing mesenchymal stem cells (MSC) as well as endothelial progenitor cells (EPC) for enhancing bone growth in severe atrophic cases. Stem/progenitor cell-based regenerative therapy may prove to be the best option to meet individual patient needs and open new horizons in periodontal, maxillofacial and implant surgery.
Department of Periodontology, School of Graduate Dentistry, Laboratory of Bone Repair, Rambam Health Care Campus, Hailfa, Israel. hadar@technion.ac.il
Hadar
H
Zigdon
Liran
L
Levin
D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D042783:Endothelial Cells / Q000637:transplantation; D005544:Forecasting; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D018919:Neovascularization, Physiologic / Q000502:physiology; D010006:Osteoblasts / Q000637:transplantation; D010012:Osteogenesis / Q000502:physiology; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
D036341:Intercellular Signaling Peptides and Proteins