Functional genomics suggest neurogenesis in the adult human olfactory bulb.
The human olfactory bulb displays high morphologic dynamics changing its volume with olfactory function, which has been explained by active neurogenetic processes. Discussion continues whether the human olfactory bulb hosts a continuous turnover of neurons. We analyzed the transcriptome via RNA quantification of adult human olfactory bulbs and intersected the set of expressed transcriptomic genes with independently available proteomic expression data. To obtain a functional genomic perspective, this intersection was analyzed for higher-level organization of gene products into biological pathways established in the gene ontology database. We report that a fifth of genes expressed in adult human olfactory bulbs serve functions of nervous system or neuron development, half of them functionally converging to axonogenesis but no other non-neurogenetic biological processes. Other genes were expectedly involved in signal transmission and response to chemical stimuli. This provides a novel, functional genomics perspective supporting the existence of neurogenesis in the adult human olfactory bulb.
Institute of Clinical Pharmacology, Goethe-University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany, j.loetsch@em.uni-frankfurt.de.
Jörn
J
Lötsch
Elke
E
Schaeffeler
Michel
M
Mittelbronn
Stefan
S
Winter
Volker
V
Gudziol
Stephan W
SW
Schwarzacher
Thomas
T
Hummel
Alexandra
A
Doehring
Matthias
M
Schwab
Alfred
A
Ultsch
D000328:Adult; D016208:Databases, Factual; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D055495:Neurogenesis / Q000235:genetics*; D009830:Olfactory Bulb / Q000378:metabolism*; D040901:Proteomics