A general palladium-catalyzed carbonylative synthesis of chromenones from salicylic aldehydes and benzyl chlorides.
Cute CO! An interesting and straightforward procedure for the carbonylative synthesis of chromenones from readily available salicylic aldehydes and benzyl chlorides has been developed (see scheme; DPPP = 1,3-bis(diphenylphosphino)propane). In the presence of a palladium catalyst, various coumarins were produced in good to excellent yields.
Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province 310018 (P.R. China); Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert-Einstein-Strasse 29a, 18059 Rostock (Germany). xiao-feng.wu@catalysis.de.
Xiao-Feng
XF
Wu
Lipeng
L
Wu
Ralf
R
Jackstell
Helfried
H
Neumann
Matthias
M
Beller
D000447:Aldehydes / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry*; D011407:Propane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D020156:Salicylic Acid / Q000737:chemistry*
D000447:Aldehydes; D001593:Benzyl Compounds; D002867:Chromones; D010720:Phosphines; C467590:1,3-bis(diphenylphosphino)propane; D010165:Palladium; C021292:benzyl chloride; D020156:Salicylic Acid; D011407:Propane
benzyl chlorides; carbonylation; chromenones; palladium; salicylic aldehydes