An efficient procedure for the preparation of natural products bearing the 2-(2-phenylethyl)chromone skeleton.
Several 2-(2-phenylethyl)chromones have been shown to possess neuroprotective activity. However, limited synthetic methods have been disclosed to construct the 2-(2-phenylethyl)chromone skeleton. Herein we report a straightforward 3-step preparation of five naturally occurring 2-(2-phenylethyl)chromones utilizing the Claisen condensation as the key step.
Department of Pharmacology and Toxicology, Virginia Commonwealth University,410 North 12th Street, P.O. Box 980613, Richmond, VA 23298 ; Department of Chemistry, Lynchburg College, 1501 Lakeside Drive, Lynchburg, VA 24501.
Dwight A
DA
Williams
Cameron
C
Smith
Yan
Y
Zhang
2-(2-phenylethyl)chromones; Chromenes; Claisen condensation; Neuroprotection