Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children.
Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.
Department of Clinical Biochemistry and Immunology, Statens Serum Institut.
Bright
B
Adu
Micha Phill Grønholm
MP
Jepsen
Thomas A
TA
Gerds
Eric
E
Kyei-Baafour
Michael
M
Christiansen
Daniel
D
Dodoo
Michael
M
Theisen
D000913:Antibodies, Protozoan / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005869:Ghana; D006801:Humans; D007223:Infant; D008288:Malaria / Q000276:immunology*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*
D000913:Antibodies, Protozoan; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D017452:Receptors, IgG
FCGR3B-c.233C>A; FcγRIIIB; GLURP; Plasmodium falciparum; effect modification; malaria; neutrophils