Relationship between neutrophil-lymphocyte ratio and isolated low high-density lipoprotein cholesterol.
Several studies showed that high-density lipoprotein cholesterol (HDL-C) has anti-inflammatory effect. The neutrophil-lymphocyte ratio (NLR) is a new biomarker of systemic inflammation. The aim of this study was to assess the NLR in healthy participants with low HDL-C. We studied 69 patients with low HDL-C (≤ 35 mg/dL) and 59 control participants (HDL-C >35 mg/dL) with similar cardiovascular risk factors. Hematological indices were measured in all patients with low HDL-C and control participants. The HDL-C was significantly lower among the patients with low HDL-C than that of the control group (31.7 ± 2.7 vs 50.7 ± 5.0 mg/dL, respectively; P < .001). The NLR was significantly higher among the patients with low HDL-C than that of the control group (2.6 ± 0.8 vs 1.6 ± 0.4, respectively; P < .001). The NLR was negatively correlated with HDL-C (P < .001, r = -.53). The NLR is significantly elevated in patients with low HDL-C when compared with control participants.
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey drercanvarol@yahoo.com.
Ercan
E
Varol
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Hasan Aydin
HA
Bas
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Fatih
F
Aksoy
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Hatem
H
Ari
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Mehmet
M
Ozaydin
D000328:Adult; D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007958:Leukocyte Count; D008075:Lipoproteins, HDL / Q000097:blood*; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D014280:Triglycerides
high-density lipoprotein cholesterol; inflammation; neutrophil–lymphocyte ratio