Role of B-type natriuretic peptide as a marker of mortality in acute kidney injury patients treated with continuous renal replacement therapy.
OBJECTIVE
Acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) is associated with poor outcome. Plasma B-type natriuretic peptide (BNP) is a biomarker related to fluid volume overload, and is elevated in AKI patients. The purpose of the study was to assess whether BNP levels at the time of starting CRRT could be used as a predictor of mortality in patients with AKI receiving CRRT.


METHODS
We conducted a prospective observational cohort study enrolling 149 patients with AKI receiving CRRT. The primary outcome was mortality during CRRT.


RESULTS
The median BNP level of 84 (56.3%) patients who expired was significantly higher than that of those who survived (1812.5 vs. 475.0 pg/mL; p = 0.01). Receiver operating characteristic curves demonstrated BNP levels as a predictor of mortality during CRRT with an area under the curve of 0.77 (p = 0.000), and the optimal threshold for BNP was 1054 pg/mL. Patients with BNP levels above 1054 pg/mL had a significantly higher mortality (76.6 vs. 34.7%; p = 0.01).


CONCLUSIONS
Elevated BNP level is associated with mortality in patients with AKI receiving CRRT.
Department of Internal Medicine, Dong-A University College of Medicine , Busan , Korea.
Eu Gene
EG
Jeong
Hwa Seong
HS
Nam
Su Mi
SM
Lee
Won Suk
WS
An
Seong Eun
SE
Kim
Young Ki
YK
Son
D058186:Acute Kidney Injury / Q000097:blood / Q000401:mortality* / Q000628:therapy; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D017582:Renal Replacement Therapy; D056910:Republic of Korea / Q000453:epidemiology
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain