A prospective cohort study evaluating a novel colonoscopy platform featuring full-spectrum endoscopy.
OBJECTIVE
Although colonoscopy is the criterion standard for detecting colorectal adenomas and cancers, a significant percentage of adenomas are missed with this technique. We aimed to establish the feasibility, usability, and safety of a novel colonoscopy platform featuring full-spectrum endoscopy (FUSE).


METHODS
This was a prospective, single-center pilot and feasibility study. In total, 50 individuals, ages 18 - 70 years, underwent colonoscopy featuring FUSE (up to 330° field of view) for colorectal cancer screening, polyp surveillance, or diagnostic evaluation. Study end points included success of cecal intubation, time to cecal intubation, withdrawal time, total procedure time, success of therapeutic interventions, adverse events, and endoscopists' subjective evaluation of FUSE.


RESULTS
Cecal intubation was achieved in 50/50 individuals (100 %). Time to cecum (minutes, mean ± SD) was 3.1 ± 1.5 minutes, withdrawal time 12.7 ± 4.4 minutes, and total procedure time 15.3 ± 4.6 minutes. In 22/50 cases (44 %), 26 therapeutic interventions were performed: 19 (73.1 %) biopsies and 7 (26.9 %) polypectomies. No acute or delayed adverse events were observed. Patient satisfaction and endoscopist subjective evaluation were high.


CONCLUSIONS
A colonoscopy platform featuring full-spectrum endoscopy appears feasible, usable, and safe. These results represent an important advance in colonoscopy imaging technology and should be further pursued in comparative human studies.
Department of Gastroenterology, Technion-Israel Institute of Technology, Haifa, Israel. i_gralnek@rambam.health.gov.il
Ian Mark
IM
Gralnek
Ori
O
Segol
Alain
A
Suissa
Peter D
PD
Siersema
David L
DL
Carr-Locke
Zamir
Z
Halpern
Erwin
E
Santo
Svetlana
S
Domanov
D000236:Adenoma / Q000175:diagnosis* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D001291:Attitude of Health Personnel; D002432:Cecum; D003113:Colonoscopy / Q000009:adverse effects / Q000295:instrumentation*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D055088:Early Detection of Cancer / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007440:Intubation; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D017060:Patient Satisfaction; D010865:Pilot Projects; D013997:Time Factors; D055815:Young Adult