Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter.
Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential criteria to aid target selection are described. Then the physiochemical properties of typical oral drugs are discussed and compared to those of known anti-parasitics.
Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Ian H
IH
Gilbert
D001682:Biological Availability; D004304:Dosage Forms; D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D016503:Drug Delivery Systems; D055808:Drug Discovery; D004351:Drug Resistance; D006801:Humans; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D014347:Trypanosoma brucei gambiense / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000469:parasitology
D004304:Dosage Forms; D014344:Trypanocidal Agents