PROcEED: Probabilistic reverse dosimetry approaches for estimating exposure distributions.
As increasing amounts of biomonitoring survey data become available, a new discipline focused on converting such data into estimates of chemical exposures has developed. Reverse dosimetry uses a pharmacokinetic model along with measured biomarker concentrations to determine the plausible exposure concentrations-- a critical step to incorporate ground-truthing experimental data into a distribution of probable exposures that reduces model uncertainty and variability. At the population level, probabilistic reverse dosimetry can utilize a distribution of measured biomarker concentrations to identify the most likely exposure concentrations (or intake doses) experienced by the study participants. PROcEED is software that provides access to probabilistic reverse dosimetry approaches for estimating exposure distributions via a simple user interface.


BACKGROUND
PROcEED along with installation instructions is freely available for download from http://www.epa.gov/heasd/products/proceed/proceed.html.
National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
Christopher M
CM
Grulke
Kathleen
K
Holm
Michael-Rock
MR
Goldsmith
Yu-Mei
YM
Tan
Biomarkers; Exposure; PBPK Modeling; Reverse Dosimetry