Human kidney cell reprogramming: applications for disease modeling and personalized medicine.
The ability to reprogram fully differentiated cells into a pluripotent embryonic state, termed induced pluripotent stem cells (iPSCs), has been met with great excitement. iPSC technology has advanced the fundamental study of disease modeling with the potential for cell-replacement therapy, especially in the neuronal and cardiac fields. However, renal medicine as of yet has not benefited from similar advancements. This review summarizes the unique characteristics of iPSCs and their potential applications for modeling kidney disease. Pioneering such endeavors could yield constructs that recapitulate disease phenotypes, open avenues for more targeted drug development, and potentially serve as replenishable sources for replacement of kidney cells in the setting of human disease.
Department of Pediatrics, Dunedin School of Medicine, Otago University, New Zealand.
Adam C
AC
O'Neill
Sharon D
SD
Ricardo
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000502:physiology; D007668:Kidney / Q000166:cytology* / Q000502:physiology; D007674:Kidney Diseases / Q000628:therapy*; D051379:Mice; D023421:Models, Animal; D008954:Models, Biological; D057285:Precision Medicine / Q000639:trends*; D012038:Regeneration / Q000502:physiology; D044968:Regenerative Medicine / Q000639:trends; D014981:Xenopus