Brain development in infants born preterm: looking beyond injury.
Infants born very preterm are high risk for acquired brain injury and disturbances in brain maturation. Although survival rates for preterm infants have increased in the last decades owing to improved neonatal intensive care, motor disabilities including cerebral palsy persist, and impairments in cognitive, language, social, and executive functions have not decreased. Evidence from neuroimaging studies exploring brain structure, function, and metabolism has indicated abnormalities in the brain development trajectory of very preterm-born infants that persist through to adulthood. In this chapter, we review neuroimaging approaches for the identification of brain injury in the preterm neonate. Advances in medical imaging and availability of specialized equipment necessary to scan infants have facilitated the feasibility of conducting longitudinal studies to provide greater understanding of early brain injury and atypical brain development and their effects on neurodevelopmental outcome. Improved understanding of the risk factors for acquired brain injury and associated factors that affect brain development in this population is setting the stage for improving the brain health of children born preterm.
Neurosciences & Mental Health, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. emma.duerden@sickkids.ca
Emma G
EG
Duerden
Margot J
MJ
Taylor
Steven P
SP
Miller
D001921:Brain / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology*; D001930:Brain Injuries; D002658:Developmental Disabilities / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D006801:Humans; D007234:Infant, Premature / Q000254:growth & development* / Q000523:psychology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D036421:Nerve Fibers, Unmyelinated / Q000473:pathology; D059906:Neuroimaging; D018696:Neuroprotective Agents / Q000627:therapeutic use; D012307:Risk Factors
D018696:Neuroprotective Agents