New phenstatin-fatty acid conjugates: synthesis and evaluation.
New phenstatin-fatty acid conjugates have been synthesized and tested against the KB-3-1, H460, MCF-7 and HEK293 cell lines, with an increase in anti-proliferative activity being observed at the micro-molar level paralleling an increase in un-saturation in the fatty acid component.
Department of Chemistry, St. John's University, Jamaica, NY 11439, USA.
Jinhui
J
Chen
David P
DP
Brown
Yi-Jun
YJ
Wang
Zhe-Sheng
ZS
Chen
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001577:Benzophenones / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000737:chemistry / Q000494:pharmacology*; D057809:HEK293 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D010755:Organophosphates / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001577:Benzophenones; D005227:Fatty Acids; D010755:Organophosphates; C112107:phenstatin phosphate
Cancer chemotherapy; Conjugates; Drug resistance reversal; Fatty acids; Microtubule-binding drugs