O2-Protected Diazeniumdiolate-Modified Silica Nanoparticles for Extended Nitric Oxide Release from Dental Composites.
O2-protectedN-diazeniumdiolate-based silanes were grafted onto mesoporous silica nanoparticles to yield a scaffold with an NO payload of 2.4 μmol NO/mg and NO release half-life of 23 d. Reduced (3-log)Streptococcus mutansviable adhesion was observed for NO-releasing dental restorative materials modified with these particles relative to controls.
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; schoenfisch@unc.edu.
Alexis W
AW
Carpenter
Katelyn P
KP
Reighard
Joseph E
JE
Saavedra
Mark H
MH
Schoenfisch