Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group.
The use of the tert-butyloxycarbonyl (Boc) as the Nα-amino protecting group in peptide synthesis can be advantageous in several cases, such as synthesis of hydrophobic peptides and peptides containing ester and thioester moieties. The primary challenge of using Boc SPPS is the need for treatment of the resin-bound peptide with hazardous hydrogen fluoride (HF), which requires special equipment.
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Søren W
SW
Pedersen
Christopher J
CJ
Armishaw
Kristian
K
Strømgaard
D000596:Amino Acids / Q000737:chemistry*; D005563:Formic Acid Esters / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D060327:Solid-Phase Synthesis Techniques / Q000379:methods
D000596:Amino Acids; D005563:Formic Acid Esters; D010455:Peptides; C000345:t-butyloxycarbonyl group