Risk of sedation for diagnostic esophagogastroduodenoscopy in obstructive sleep apnea patients.
OBJECTIVE
To investigate whether patients with obstructive sleep apnea (OSA) are at risk of sedation-related complications during diagnostic esophagogastroduodenoscopy (EGD).


METHODS
A prospective study was performed in consecutive patients with OSA, who were confirmed with full-night polysomnography between July 2010 and April 2011. The occurrence of cardiopulmonary complications related to sedation during diagnostic EGD was compared between OSA and control groups.


RESULTS
During the study period, 31 patients with OSA and 65 controls were enrolled. Compared with the control group, a higher dosage of midazolam was administered (P = 0.000) and a higher proportion of deep sedation was performed (P = 0.024) in the OSA group. However, all adverse events, including sedation failure, paradoxical responses, snoring or apnea, hypoxia, hypotension, oxygen or flumazenil administration, and other adverse events were not different between the two groups (all P > 0.1). Patients with OSA were not predisposed to hypoxia with multivariate logistic regression analysis (P = 0.068).


CONCLUSIONS
In patients with OSA, this limited sized study did not disclose an increased risk of cardiopulmonary complications during diagnostic EGD under sedation.
Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Seoul 134-727, South Korea. drcha@khu.ac.kr
Jae Myung
JM
Cha
Jung Won
JW
Jeun
Kwan Mi
KM
Pack
Joung Il
JI
Lee
Kwang Ro
KR
Joo
Hyun Phil
HP
Shin
Won-Chul
WC
Shin
D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D054810:Deep Sedation / Q000009:adverse effects*; D016145:Endoscopy, Digestive System / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects*; D007022:Hypotension / Q000209:etiology; D000860:Hypoxia / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D017286:Polysomnography; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012140:Respiratory Tract Diseases / Q000209:etiology; D018570:Risk Assessment; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000175:diagnosis
D006993:Hypnotics and Sedatives; D008874:Midazolam
Complications; Conscious sedation; Endoscopy; Obstructive sleep apnea; Safety