Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment.
Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Jae-Hyun
JH
Park
Sang Won
SW
Seo
Changsoo
C
Kim
Sook Hui
SH
Kim
Geon Ha
GH
Kim
Sung Tae
ST
Kim
Seun
S
Jeon
Jong Min
JM
Lee
Seung Jun
SJ
Oh
Jae Seung
JS
Kim
Yearn Seong
YS
Choe
Kyung-Han
KH
Lee
Ji Soo
JS
Shin
Chi Hun
CH
Kim
Young
Y
Noh
Hanna
H
Cho
Cindy W
CW
Yoon
Hee Jin
HJ
Kim
Byoung Seok
BS
Ye
Michael
M
Ewers
Michael W
MW
Weiner
Jae-Hong
JH
Lee
David J
DJ
Werring
Duk L
DL
Na
D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000150:complications*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D013844:Thiazoles
Amyloid; Cerebrovascular disease; Cognition; Lacune; Microbleed; Pittsburgh compound B; White matter hyperintensity