Fate choice of post-natal mesoderm progenitors: skeletal versus cardiac muscle plasticity.
Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.
Translational Cardiomyology Lab, Department of Development and Regeneration, Stem Cell Institute Leuven, Embryo and Stem Cell Biology, KU Leuven, Herestraat 49, O&N4, Bus 814, 3000, Leuven, Belgium.
Domiziana
D
Costamagna
Mattia
M
Quattrocelli
Robin
R
Duelen
Vardine
V
Sahakyan
Ilaria
I
Perini
Giacomo
G
Palazzolo
Maurilio
M
Sampaolesi
D000818:Animals; D047108:Embryonic Development; D006321:Heart / Q000502:physiology; D006801:Humans; D008648:Mesoderm / Q000166:cytology*; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000166:cytology* / Q000502:physiology; D009206:Myocardium / Q000166:cytology*; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology*