Review: molecular mechanism of microglia stimulated glioblastoma invasion.
Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention.
Albert Einstein College of Medicine, Department of Anatomy and Structural Biology, Bronx, NY 10461, United States. Electronic address: salvatore.coniglio@einstein.yu.edu.
Salvatore J
SJ
Coniglio
Jeffrey E
JE
Segall
D016207:Cytokines / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005909:Glioblastoma / Q000503:physiopathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008264:Macrophages / Q000502:physiology*; D017628:Microglia / Q000502:physiology*; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D019899:Paracrine Communication / Q000502:physiology*; D010447:Peptide Hydrolases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D016207:Cytokines; D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins; D010447:Peptide Hydrolases
CSF-1R; Glioma; Invasion; MMPs; Macrophages; Microglia; TGFβ