Genetic engineering of T-cell receptors: TCR takes to titin.
In this issue of Blood, Linette et al report a cautionary tale—a lethal off-target toxicity following T-cell receptor (TCR) optimization to enhance affinity against a tumor-associated antigen, MAGE-A3.
Baylor College of Medicine.
Helen E
HE
Heslop
D002318:Cardiovascular Diseases / Q000150:complications*; D064211:Connectin; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood*; D009101:Multiple Myeloma / Q000097:blood*; D009124:Muscle Proteins / Q000378:metabolism*; D009206:Myocardium / Q000473:pathology*; D011494:Protein Kinases / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology*
D064211:Connectin; D009124:Muscle Proteins; C577285:TTN protein, human; D011494:Protein Kinases