Genetic variants in hormone-related genes and risk of breast cancer.
Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer. Our results suggest that these genetic variants do not have a strong effect on breast cancer risk.
Department of Population Health, New York University School of Medicine, New York, New York, United States of America. tess.clendenen@nyumc.org
Tess
T
Clendenen
Anne
A
Zeleniuch-Jacquotte
Isaac
I
Wirgin
Karen L
KL
Koenig
Yelena
Y
Afanasyeva
Eva
E
Lundin
Alan A
AA
Arslan
Tomas
T
Axelsson
Asta
A
Försti
Göran
G
Hallmans
Kari
K
Hemminki
Per
P
Lenner
Nirmal
N
Roy
Roy E
RE
Shore
Yu
Y
Chen
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D003710:Demography; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006728:Hormones / Q000235:genetics*; D006801:Humans; D008019:Life Style; D008593:Menopause / Q000235:genetics; D008875:Middle Aged; D012307:Risk Factors
D006728:Hormones