[A case of bladder cancer producing granulocyte colony-stimulating factor and interleukin-6 causing respiratory failure treated with neoadjuvant systemic chemotherapy along with sivelestat].
A 67-year-old man visited an urological clinic with a chief complaint of urination pain. Cystourethroscopy and magnetic resonance imaging (MRI) examination revealed a bladder tumor (cT3bN0M0). Marked leukocytosis and respiratory distress with pleural effusion appeared. Pulse steroid therapy improved the general condition partially. The patient was sent to our hospital for further examination. Serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) were high and the pathological findings of bladder tumor obtained by transurethral resection (TUR) revealed an urothelial carcinoma that produced G-CSF and IL-6. Neoadjuvant systemic chemotherapy was performed along with use of steroid and sivelestat, which ameliorated the respiratory distress. After three courses of systemic chemotherapy, serum G-CSF and IL-6 normalized and cystoprostatectomy was performed. The patient has been in good health at 20 months after the surgery with no evidence of recurrence.
The Department of Urology, Osaka University Graduate School of Medicine, Japan.
Kyosuke
K
Matsuzaki
Masayoshi
M
Okumi
Nozomu
N
Kishimoto
Koji
K
Yazawa
Yasushi
Y
Miyagawa
Kinya
K
Uchida
Norio
N
Nonomura
D000368:Aged; D002277:Carcinoma / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D008297:Male; D020360:Neoadjuvant Therapy; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*
D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor