Synthesis of cyclic disulfide-rich peptides.
In this chapter we describe two SPPS approaches for producing cyclic disulfide-rich peptides in our laboratory, including cyclotides from plants, cyclic conotoxins from cone snail venoms, chlorotoxin from scorpion venom, and the sunflower trypsin inhibitor peptide, SFTI-1.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Muharrem
M
Akcan
David J
DJ
Craik
D000596:Amino Acids / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry*; D005449:Fluorenes / Q000737:chemistry; D005563:Formic Acid Esters / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques / Q000379:methods
D000596:Amino Acids; D004220:Disulfides; D005449:Fluorenes; D005563:Formic Acid Esters; D010456:Peptides, Cyclic; C000345:t-butyloxycarbonyl group