Haemolytic uraemic syndrome associated with Pseudomonas aeruginosa sepsis.
Haemolytic uraemic syndrome (HUS) is a recognized complication of infection with Shiga toxin-producing Escherichia coli (STEC) and Shigella dysenteriae type 1. Infections with other micro-organisms, especially Streptococcus pneumoniae, have been cited as causes of HUS. In addition, influenza virus and other viruses may rarely be associated with this syndrome. A 2-year-old girl presented with severe Pseudomonas aeruginosa sepsis with renal failure and ecthyma gangrenosum. Further investigations revealed features of HUS. She was managed with antibiotics and other supportive measures including peritoneal dialysis, and subsequently made a full recovery. A possible role of neuraminidase in the pathogenesis of P. aeruginosa-associated HUS was proposed. This is the first reported case of P. aeruginosa sepsis leading to HUS.
Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India.
Parameswaran
P
Narayanan
Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India.
Rashi S
RS
Rustagi
Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India.
Prabha
P
Sivaprakasam
Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India.
Mahadevan
M
Subramanian
Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India.
Sreejith
S
Parameswaran
Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India.
Jharna
J
Mandal
Department of Pediatrics, Division of Nephrology, The Children's Hospital of Philadelphia, 34th Street and Civic Centre Boulevard, Philadelphia, PA 19104, USA.
B S
BS
Kaplan
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D009439:Neuraminidase / Q000633:toxicity; D010530:Peritoneal Dialysis; D011552:Pseudomonas Infections / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D018805:Sepsis / Q000150:complications* / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D009439:Neuraminidase