Life cycle analysis of solvent reduction in pharmaceutical synthesis using continuous adsorption for palladium removal.
The life cycle emissions associated with the reduction of wastes from an adsorption process to remove palladium complexes in drug manufacture have been evaluated. The study assessed a green improvement to a process step in an active pharmaceutical ingredient synthesis where palladium catalyst is removed from a reaction mixture. The greener process uses a continuous adsorption system, composed of a more efficient adsorbent, consuming less organic solvent and rinse water, which results in less waste disposal. The newer process is also more energy and cost efficient from an operational perspective. There is a 94% reduction in the carbon footprint of the new process when compared to the current operation.
Department of Chemical Engineering, Rowan University, Glassboro, NJ 08028, USA. slater@rowan.edu
C Stewart
CS
Slater
Mariano J
MJ
Savelski
Marie Nydia
MN
Ruiz-Felix
D000327:Adsorption; D058572:Carbon Footprint; D002384:Catalysis; D055772:Green Chemistry Technology / Q000191:economics / Q000379:methods*; D010165:Palladium / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D014865:Waste Disposal, Fluid / Q000191:economics / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000737:chemistry*
D012997:Solvents; D014874:Water Pollutants, Chemical; D010165:Palladium