From natural product-inspired pyrrolidine scaffolds to the development of new human Golgi α-mannosidase II inhibitors.
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan).
Ting-Jen R
TJ
Cheng
Ting-Hao
TH
Chan
En-Lun
EL
Tsou
Shang-Yu
SY
Chang
Wen-Yi
WY
Yun
Pei-Jung
PJ
Yang
Ying-Ta
YT
Wu
Wei-Chieh
WC
Cheng
D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D001688:Biological Products / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008361:Mannosidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D062105:Molecular Docking Simulation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011759:Pyrrolidines / Q000737:chemistry*
D000470:Alkaloids; D001688:Biological Products; D004791:Enzyme Inhibitors; D011759:Pyrrolidines; D008361:Mannosidases; C038829:mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase; C032519:pyrrolidine
alkaloids; combinatorial chemistry; natural products; pyrrolidine-based scaffold; synthetic inhibitors