Molecular mechanism of prion protein oligomerization at atomic resolution.
Prion protein oligomerization: Despite the crucial role of oligomers during prion protein (PrP) pathogenesis the molecular mechanism of their formation has remained largely elusive. A 2D time-resolved NMR study which made it possible to characterize the oligomerization kinetics with unprecedented site-specificity is reported.
Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany) http://schwalbe.org.chemie.uni-frankfurt.de.
Kai
K
Schlepckow
Harald
H
Schwalbe
D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011328:Prions / Q000737:chemistry*; D011487:Protein Conformation
D011328:Prions
NMR spectroscopy; kinetics; mechanistic studies; oligomerization; prion proteins