Twenty-fold acceleration of 3D projection reconstruction MPI.
We experimentally demonstrate a 20-fold improvement in acquisition time in projection reconstruction (PR) magnetic particle imaging (MPI) relative to the state-of-the-art PR MPI imaging results. We achieve this acceleration in our imaging system by introducing an additional Helmholtz electromagnet pair, which creates a slow shift (focus) field. Because of magnetostimulation limits in humans, we show that scan time with three-dimensional (3D) PR MPI is theoretically within the same order of magnitude as 3D MPI with a field free point; however, PR MPI has an order of magnitude signal-to-noise ratio gain.
Justin J
JJ
Konkle
Patrick W
PW
Goodwill
Emine Ulku
EU
Saritas
Bo
B
Zheng
Kuan
K
Lu
Steven M
SM
Conolly
D000465:Algorithms; D017076:Computer-Aided Design; D003287:Contrast Media; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D058185:Magnetite Nanoparticles; D057054:Molecular Imaging / Q000295:instrumentation* / Q000379:methods; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D003287:Contrast Media; D058185:Magnetite Nanoparticles