Invasive fungal infections: biomarkers and molecular approaches to diagnosis.
The biomarkers galactomannan and 1,3-β-d-glucan have been well studied over the past years and are gaining a role in the diagnosis of invasive fungal infections. Although not as well studied until recently, molecular methods for the diagnosis of invasive fungal infection are also being evaluated. Outcomes data for molecular testing are expanding, but have not yet provided enough evidence for inclusion of molecular diagnostics in formal clinical guidelines. Lack of standardization and validation of the various molecular assays and platforms has hindered their widespread acceptance in the evaluation of invasive fungal infections, although the future is promising.
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th Street, Starr 737C, New York, NY 10065, USA. ans9112@med.cornell.edu
Audrey N
AN
Schuetz
D001228:Aspergillosis / Q000175:diagnosis* / Q000382:microbiology; D015415:Biomarkers / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002177:Candidiasis / Q000175:diagnosis* / Q000382:microbiology; D005189:False Positive Reactions; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D008351:Mannans / Q000097:blood / Q000378:metabolism*; D057089:Pathology, Molecular / Q000379:methods*; D016133:Polymerase Chain Reaction / Q000379:methods; D011237:Predictive Value of Tests; D013402:Sugar Alcohols / Q000097:blood; D047071:beta-Glucans / Q000097:blood / Q000378:metabolism
D015415:Biomarkers; D008351:Mannans; D013402:Sugar Alcohols; D047071:beta-Glucans; C012990:galactomannan; C033363:beta-1,3-glucan; D005690:Galactose; C014999:arabitol
Aspergillosis; Biomarker; Candidiasis; Galactomannan; Invasive fungal infection; Molecular; Polymerase chain reaction; β-d-Glucan