Encapsulation of drug molecules into calix[n]arene nanobaskets. role of aminocalix[n]arenes in biopharmaceutical field.
Calix[n]arenes (CAs) are supramolecular compounds able to form guest-host inclusion complexes with metal ions, small organic molecules, and small moieties of larger molecules. Although the CA literature is extensive, relatively few publications deal with water-soluble CAs, especially those containing nitrogen-based functionality. These CAs possess antibacterial and antifungal activity. Because of their molecular structure, they are surface active and also able to form water-soluble drug complexes, giving additional potential as enabling pharmaceutical excipients. This article provides an overview of the published data regarding synthesis, physicochemical properties, and pharmaceutical application of water-soluble CAs with emphasis on those that contain nitrogen-based substituents in their structure, particularly aminoCAs. In particular, it describes state-of-the-art in complexation of water-soluble CAs with pharmaceutically relevant ions and organic molecules up to amino acids, DNA, and proteins.
Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, IS-107, Iceland.
Elena V
EV
Ukhatskaya
Sergey V
SV
Kurkov
Susan E
SE
Matthews
Thorsteinn
T
Loftsson
D000596:Amino Acids / Q000737:chemistry*; D047250:Calixarenes / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
D000596:Amino Acids; D004364:Pharmaceutical Preparations; D014867:Water; D047250:Calixarenes
antiinfectives; calixarene; complexation; excipients; inclusion compounds; interaction; nanoparticles; structure-activity relationship; surfactants