Best BETs from the Manchester Royal Infirmary. BET 1: intranasal lorazepam is an acceptable alternative to intravenous lorazepam in the control of acute seizures in children.
A short-cut review was carried out to determine whether intranasal lorazepam was as effective as intravenous lorazepam in the control of seizures in children. Eighteen papers were found using the reported search, of which one was directly relevant and another compared intranasal lorazepam with intramuscular paraldehyde. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses are shown in table 1. It is concluded that intranasal lorazepam appears to be a safe and effective treatment for this condition.
University of Cambridge School of Clinical Medicine, Cambridge, UK.
Anna
A
Allan
Jayne
J
Cullen
D000208:Acute Disease; D000281:Administration, Intranasal; D000927:Anticonvulsants / Q000008:administration & dosage*; D002675:Child, Preschool; D055416:Evidence-Based Emergency Medicine; D006801:Humans; D007275:Injections, Intravenous; D008140:Lorazepam / Q000008:administration & dosage*; D012640:Seizures / Q000188:drug therapy*
D000927:Anticonvulsants; D008140:Lorazepam