Radionuclide-guided biopsy of bone lesions in cancer patients; a reliable, well-tolerated technique.
OBJECTIVE
In follow up or primary analysis of malignant disease, use of nuclear medicine imaging techniques is increasing. The lesions, detected by these modalities, do not always present with a matching radiological abnormality suitable for radiological biopsy. A method to confirm, or rule out, metastatic disease in these cases is radionuclide-guided surgical biopsy.


METHODS
The technique consists of injecting a Technetium-99m labelled diphosphonate, performing a bone scan and marking the lesion; under general anaesthetic a surgical biopsy is taken through a small incision guided by a gamma-probe. We evaluated the combined experience of two teaching hospitals, by conducting retrospective chart review, over a period of 5.5 years. Sixty-nine procedures with 79 biopsies were performed. The patients previously had breast cancer in 42%, lung cancer in 32%, both gastrointestinal and urological malignancies in 13%, miscellaneous or unknown origin were reported in 9%. In 68% a rib biopsy was taken, in 15% a pelvis biopsy and in 11% a sternum or clavicle biopsy.


RESULTS
In 46.8% metastatic disease was confirmed and in 2.6% a new malignancy (M Kahler) was identified. During a median clinical follow up period of 31 months (1-70), 1 initially negative biopsy site was found to contain a metastasis. Apart from local pain in 3% of cases, no complications were mentioned.


CONCLUSIONS
In conclusion we can state that, in this retrospective series, radionuclide-guided bone biopsy is a reliable, well-tolerated technique to determine the diagnosis of these lesions with a sensitivity of 97% and specificity of 100%.
Atrium Medical Centre, Department of Surgery, PO Box 4446, 6401CX Heerlen, The Netherlands. Electronic address: emvonm@gmail.com.
E M
EM
von Meyenfeldt
Atrium Medical Centre, Department of Surgery, PO Box 4446, 6401CX Heerlen, The Netherlands; Orbis Medical Centre, Department of Surgery, PO Box 5500, 6130 MB Sittard, The Netherlands. Electronic address: jsa02@atriummc.nl.
J
J
Siebenga
Orbis Medical Centre, Department of Nuclear Medicine, PO Box 5500, 6130 MB Sittard, The Netherlands. Electronic address: h.vanderpol@orbisconcern.nl.
H A G
HA
van der Pol
Atrium Medical Centre, Department of Nuclear Medicine, PO Box 4446, 6401CX Heerlen, The Netherlands. Electronic address: wendyschreurs@atriummc.nl.
W M J
WM
Schreurs
Atrium Medical Centre, Department of Surgery, PO Box 4446, 6401CX Heerlen, The Netherlands; Orbis Medical Centre, Department of Surgery, PO Box 5500, 6130 MB Sittard, The Netherlands. Electronic address: k.hulsewe@orbisconcern.nl.
K W E
KW
Hulsewe
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology*; D002968:Clavicle / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010384:Pelvic Bones / Q000000981:diagnostic imaging / Q000473:pathology; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012272:Ribs / Q000000981:diagnostic imaging / Q000473:pathology; D014571:Urologic Neoplasms / Q000473:pathology*
Biopsy; Neoplasm metastasis; Neoplasm staging; Radionuclide imaging