A convenient synthesis of quinolizinium salts through Rh(III) or Ru(II)-catalyzed C-H bond activation of 2-alkenylpyridines.
An efficient synthesis of quinolizinium salts from 2-vinylpyridines and alkynes via Rh(III) or Ru(II)-catalyzed C-H activation and annulation reaction is described. A possible mechanism involving pyridine assisted vinylic ortho-C-H activation, alkyne insertion and reductive elimination is proposed.
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan. chcheng@mx.nthu.edu.tw.
Ching-Zong
CZ
Luo
Parthasarathy
P
Gandeepan
Chien-Hong
CH
Cheng
D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D012492:Salts / Q000138:chemical synthesis / Q000737:chemistry
D009942:Organometallic Compounds; D011725:Pyridines; D011807:Quinolizines; D012492:Salts; D012428:Ruthenium; D012238:Rhodium