Increased orosomucoid in urine is an independent predictor of cardiovascular and all-cause mortality in patients with type 2 diabetes at 10 years of follow-up.
OBJECTIVE
To evaluate whether increased urinary orosomucoid excretion rate (UOER) is an independent predictor of cardiovascular and all-cause mortality in type 2 diabetes (T2DM) and type 1 diabetes (T1DM) at 10years of follow-up.


METHODS
We followed 430 patients with T2DM and 148 patients with T1DM until emigration, death or November 2011. We measured UOER levels in overnight urine samples.


RESULTS
Descriptive data are given in the article. In patients with T2DM and T1DM, all-cause mortality (log-rank test, p<0.01 for both types) and cardiovascular mortality (log-rank test, p<0.01 for T2DM and p=0.04 for T1DM) were significantly higher in patients with increased UOER. Normoalbuminuric patients with T2DM and increased UOER levels had higher all-cause and cardiovascular mortality (log-rank test, p<0.01 for both types). UOER was independently predictive of all-cause (HR 1.52; 95% CI 1.10-2.09; p=0.01) and cardiovascular (HR 2.31; 95% CI 1.46-3.66; p<0.01) mortality in patients with T2DM, but not in patients with T1DM.


CONCLUSIONS
UOER is an independent predictor of all-cause and cardiovascular mortality even in normoalbuminuric patients with T2DM at 10years of follow-up. Further studies are needed in order to evaluate the prognostic and clinical relevance.
Department of Internal Medicine, Amager Hospital, Copenhagen, Denmark. Electronic address: mathildesvendstrup@gmail.com.
Mathilde
M
Svendstrup
Merete Skovdal
MS
Christiansen
Erik
E
Magid
Eva
E
Hommel
Bo
B
Feldt-Rasmussen
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications / Q000175:diagnosis* / Q000401:mortality* / Q000652:urine; D002423:Cause of Death; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis* / Q000401:mortality* / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000652:urine*; D011379:Prognosis; D016019:Survival Analysis
D009961:Orosomucoid
Cardiovascular mortality; Diabetes; Mortality; Orosomucoid; Urinary orosomucoid excretion rate