Biomedical applications of immobilized enzymes: an update.
Immobilized enzymes have been widely studied during the last few decades. Biocatalyst systems may work as biosensors or may be used for the treatment of different diseases. This chapter presents different attempts to immobilize enzymes in the biomedical field, particularly the use of prolidase and superoxide dismutase as two examples of this approach. Although this chapter focuses on liposomes and nanoparticles for the entrapment of these enzymes, the methods detailed here could be adapted for the immobilization of other enzymes with therapeutic purposes.
NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country, Vitoria-Gasteiz, Spain.
Marta
M
Pastor
Amaia
A
Esquisabel
José Luis
JL
Pedraz
D000818:Animals; D055162:Biocatalysis; D048271:Chitosan / Q000737:chemistry; D004150:Dipeptidases / Q000737:chemistry; D004339:Drug Compounding; D004800:Enzymes, Immobilized / Q000737:chemistry*; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D053769:Nanocapsules / Q000737:chemistry; D050997:Nanomedicine; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013482:Superoxide Dismutase / Q000737:chemistry
D004800:Enzymes, Immobilized; D008081:Liposomes; D053769:Nanocapsules; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D048271:Chitosan; D013482:Superoxide Dismutase; D004150:Dipeptidases; C022449:proline dipeptidase