Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition.
Katsumadain A, a naturally occurring inﬂuenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner-Wadsworth-Emmons/oxa Michael addition.
The Comprehensive AIDS Research Center, Department of Pharmacology & Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Yongguang
Y
Wang
Ruiyang
R
Bao
Shengdian
S
Huang
Yefeng
Y
Tang
bioinspired synthesis; catalysis; katsumadain A; natural product; organocatalytic 1,4-conjugate addition