[Changes and clinical significance of serum level of syndecan-4 protein in patients with chronic congestive heart failure].
OBJECTIVE
To detect serum level of syndecan-4 protein in patients with chronic congestive heart failure (CHF) and investigate its correlation with New York Heart Association (NYHA) class and echocardiographic parameters.


METHODS
The concentration of serum syndecan-4 protein was measured by enzyme-linked immunosorbent assay (ELISA) in 40 patients with CHF and 40 healthy controls (NCD), respectively. The parameters such as left ventricle ejection fraction (LVEF), fraction shortening (FS), left ventricle end-diastolic diameter (LVDd), left ventricle end-systolic diameter (LVDs), left ventricle end-diastolic volume (LVEDV) and left ventricle end-systolic volume (LVESV) were detected by echocardiography in 40 patients of CHF. Meanwhile, the patients' cardiac function was graded according to NYHA class.


RESULTS
The levels of serum syndecan-4 protein significantly increased in CHF group as compared with control group (P<0.01). In CHF group, as the increased grading of NYHA cardiac function, the levels of serum syndecan-4 protein significantly increased (P<0.05). The more upgraded the NYHA grading, the higher level of serum syndecan-4 protein. In bivariate correlations analysis showed that the level of serum syndecan-4 protein was significantly negatively correlated with LVEF and FS (P<0.05) and was significantly positively correlated with LVDd, LVDs, LVEDV and LVESV, respectively (P<0.05).


CONCLUSIONS
Serum syndecan-4 concentration significantly increased in CHF patients, and it was closely correlated with NYHA class and left ventricle function parameters, so the level of serum syndecan-4 protein may have an important value in detection and surveillance of CHF.
Department of Cardiology, Southern Medical University, Guangzhou, China. maxiaoling424@163.com
Xiaoling
X
Ma
Ping
P
Ouyang
Zhineng
Z
Zhang
Wenyan
W
Lai
Dingli
D
Xu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053671:Syndecan-4 / Q000097:blood*
C508304:SDC4 protein, human; D053671:Syndecan-4