Seroepidemiologies of human metapneumovirus and respiratory syncytial virus in young children, determined with a new recombinant fusion protein enzyme-linked immunosorbent assay.
We compared antibodies against human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) in children. The antibody nadirs for both viruses were at 3 to 5 months, and the majority of children were seropositive for both by 2 years. There was no significant difference in the kinetics of maternal antibody decline or seroconversion relative to the two viruses.
Departments of Pediatrics.
Sarah R
SR
Dunn
Alex B
AB
Ryder
Sharon J
SJ
Tollefson
Meng
M
Xu
Benjamin R
BR
Saville
John V
JV
Williams
D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D029121:Metapneumovirus / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000276:immunology; D011993:Recombinant Fusion Proteins / Q000235:genetics; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000276:immunology; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology*; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral; D000956:Antigens, Viral; D011993:Recombinant Fusion Proteins