[Experimental study of new material for biocompatibility as orbital implant].
To evaluate the resin FullCure 720® biocompatibility as orbital implant. Clinical response and signs of systemic toxicity to the resin were evaluated, local biocompatibility and microscopic analysis regarding chronic local inflammatory response to the implant. The animals were weighted, biochemical exams and inflammatory response were evaluated. All animals were eviscerated and implantation of the spheres was carried out. Animals were followed for 60 days. Clinical behavior of animals and local signals of inflammation had been observed. After this period animals underwent euthanasia followed by enucleation. Macroscopic and histomorphometric analysis were performed. The results showed normal behavior of the animals, without implant exposure, extrusion, death or systemic toxicity. Capsule tissue formation was observed between the sclera and the implant. Normal inflammatory response to the foreign material in contact with the rabbit soft tissue was observed. The resin FullCure 720®, demonstrated to be biocompatible as an orbital implant in this study.
Setor de Oftalmologia, Faculdade Evangélica do Paraná - FEPAR - Curitiba (PR), Brasil. robk@ig.com.br
Rodrigo Beraldi
RB
Kormann
Hamilton
H
Moreira
Graziella
G
Crescente
José Aguiomar
JA
Foggiatto
D000180:Acrylic Resins / Q000627:therapeutic use / Q000633:toxicity*; D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D008297:Male; D008422:Materials Testing; D023421:Models, Animal; D020273:Orbital Implants; D019919:Prosthesis Implantation / Q000379:methods; D011817:Rabbits; D015203:Reproducibility of Results; D012590:Sclera / Q000187:drug effects; D013499:Surface Properties; D013997:Time Factors
D000180:Acrylic Resins; D001672:Biocompatible Materials