Clinical characteristics, etiology and antimicrobial susceptibility among overweight and obese individuals with diarrhea: observed at a large diarrheal disease hospital, Bangladesh.
BACKGROUND
The present study aimed to determine the clinical characteristics and etiology of overweight and obese (OO) individuals with diarrhea attending an urban Dhaka Hospital, International Centre for Diarrheal Disease Research (icddr,b), Bangladesh.


METHODS
Total of 508 under-5 children, 96 individuals of 5-19 years and 1331 of >19 years were identified as OO from the Diarrheal Disease Surveillance System (DDSS) between 1993-2011. Two comparison groups such as well-nourished and malnourished individuals from respective age stratums were selected.


RESULTS
Isolation rate of rotavirus was higher among OO under-5 children compared to malnourished group (46% vs. 28%). Rotavirus infection among OO individuals aged 5-19 years (9% vs. 3%) (9% vs. 3%) and >19 years (6% vs. 4%) (6% vs. 3%) was higher compared to well-nourished and malnourished children. Conversely, Vibrio cholerae was lower among all OO age groups compared to well-nourished and malnourished ones. Shigella (4% vs. 6%) (4% vs. 8%), and Campylobacter (3% vs. 5%) (3% vs. 5%) were lower only among OO in >19 years individuals compared to their counterparts of the same age stratum. Salmonella was similarly isolated in all age strata and nutritional groups. In multinomial logistic regression among under-5 children, significant association was observed only with use of antimicrobials at home [OR-1.97] and duration of hospital stay [OR-0.68]. For individuals aged 5-19 years, use of antimicrobials at home (OR-1.83), some or severe dehydration (OR-3.12), having received intravenous saline (OR-0.46) and rotavirus diarrhea (OR-2.96) were found to be associated with OO respectively. Moreover, significant associations were also found for duration of diarrhea before coming to hospital (>24 hours) (OR-1.24), Shigella (OR-0.46), and Campylobacter (OR-0.58) among >19 years OO individuals along with other associated co-variates in 5-19 years group (all p<0.05).


CONCLUSIONS
Higher proportion of OO were infected with rotavirus and a greater proportion of them used antimicrobials before coming to the hospital.
International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh.
Sumon Kumar
SK
Das
Mohammod Jobayer
MJ
Chisti
Sayeeda
S
Huq
Mohammad Abdul
MA
Malek
Lana
L
Vanderlee
Guddu
G
Kaur
Mohammed Abdus
MA
Salam
Tahmeed
T
Ahmed
Abu Syed Golam
AS
Faruque
Abdullah Al
AA
Mamun
D000293:Adolescent; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001459:Bangladesh / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology*; D062665:Epidemiological Monitoring; D006761:Hospitals / Q000706:statistics & numerical data*; D006801:Humans; D044342:Malnutrition / Q000150:complications; D009765:Obesity / Q000150:complications*; D012760:Shigella / Q000187:drug effects / Q000502:physiology; D014734:Vibrio cholerae / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
D000890:Anti-Infective Agents