[Viral and drug-induced liver damage in children with tuberculosis: prevalence, clinical features].
THE AIM OF THE RESEARCH: Improving the effectiveness of diagnostics and treatment of viral and drug-induced lesions of the liver (DILL) at a tuberculosis in children by identifying the frequency of their distribution, peculiarities of diagnostics and clinics.


METHODS
We examined 242 children in the age from 2 months to 17 years, the patients with different forms of tuberculosis.


RESULTS
The prevalence of hepatitis in children with tuberculosis: B - 1,2%, C-0.4%, G - 4,6%, TT - 8,7%. DILL was diagnosed in 67.5% of children - TB patients, in 48% of the children with DILL an asymptomatic course of the disease was noted, however, in 54.4% of the children with DILL cytolitic syndrome was expressed (ALT> standards).


CONCLUSIONS
The prevalence of viral hepatitis B and C among children with TB is low. The infection with viruses of hepatitis G and TT is more often, but has no significant impact as on the course of tuberculosis, and on the severity of the liver damage. Drug-induced liver damage is a dominant view of pathology of the liver in children - TB patients and is mostly asymptomatic, but with a pronounced cytolitic syndrome.
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Borzakova
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Aksenova
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Reĭzis
D000293:Adolescent; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D018963:Hepatitis Antigens / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008111:Liver Function Tests; D009031:Moscow; D015995:Prevalence; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology
D000995:Antitubercular Agents; D015415:Biomarkers; D018963:Hepatitis Antigens