An organocatalytic route to 2-heteroarylmethylene decorated N-arylpyrroles.
A concise and regioselective preparation of 2-heteroarylmethylene decorated N-arylpyrroles is described through a metal-free Mannich/Wittig/hydroamination sequence followed by isomerization of the N-arylpyrrolidine adducts. Furthermore, the C-H regioselective oxidation of these substrates is demonstrated, extending the molecular diversity and versatility of these scaffolds.
Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen, CNRS ; Laboratoire des Fonctions Azotées et Oxygénées Complexes de l'IRCOF, CNRS UMR 6014 & FR 3038, Université et INSA de Rouen, Mont Saint-Aignan, France.
Alexandre
A
Jean
Jérôme
J
Blanchet
Jacques
J
Rouden
Jacques
J
Maddaluno
Michaël
M
De Paolis
C–H oxidation; N-arylpyrrole; isomerization; organocatalysis