Congenital heart disease screening: which referral factors are most important?
OBJECTIVE
To identify the referral factors for fetal echocardiography which are associated with congenital cardiac defects in the fetus.


METHODS
Cross-sectional descriptive study.


METHODS
Radiology Department, CMH, Rawalpindi, from January 2007 to November 2010.


METHODS
All patients referred for fetal echocardiography with one or more risk factors for the development of congenital heart disease, and those patients with incidental discovery of congenital heart disease on antenatal ultrasound were evaluated. Patients with no risk factors who were found to have normal fetal echocardiography were excluded from the study. Univariate logistic regression analysis was carried out for each variable. The variables with statistical significance of less than 0.05 were subjected to multivariate logistic regression. Fetal echocardiographic diagnosis was taken as the dependent variable and all other variables were the independent variables.


RESULTS
Two hundred and sixty four patients were evaluated by fetal echocardiography for congenital heart disease. The statistically significant factor was detection of congenital heart disease on routine ultrasound examination.


CONCLUSIONS
A routine obstetric scan should include evaluation of the heart with four-chamber and base-of-heart views to exclude cardiac anomalies. A cardiac anomaly picked up on routine ultrasound scan is the most important indication for referral for fetal echocardiography. Fetal arrhythmias and echogenic focus in the left ventricle do not have a significant association with structural cardiac malformation.
Department of Radiology, Army Medical College, Rawalpindi, Pakistan. afshan_fayyaz@hotmail.com
Afshan
A
Fayyaz
Waqar
W
Ahmed
D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging*; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging*; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012017:Referral and Consultation / Q000706:statistics & numerical data*; D012307:Risk Factors; D016216:Ultrasonography, Prenatal / Q000379:methods*; D055815:Young Adult