MicroRNA-106a induces multidrug resistance in gastric cancer by targeting RUNX3.
Multidrug resistance (MDR) is the main barrier to the success of chemotherapy for gastric cancer (GC). miR-106a, which is highly expressed in GC, influences a variety of aspects of GC. However, the function of miR-106a in MDR of GC still remains unclear. In the present study, we found that miR-106a is elevated in MDR cell lines. miR-106a promotes chemo-resistance of GC cells, accelerates ADR efflux, and suppresses drug-induced apoptosis. Finally, we show that runt-related trans factor 3 (RUNX3) is the functional target of miR-106a. Collectively, these findings demonstrate that miR-106a may promote MDR in GC cells by targeting RUNX3.
Department of General Surgery, Wuhan General Hospital of Guangzhou Command, 627#, Wuluo Road, Wuhan 430070, China.
Yi
Y
Zhang
Qiping
Q
Lu
Xun
X
Cai
D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics* / Q000378:metabolism; D019008:Drug Resistance, Neoplasm / Q000187:drug effects* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D017930:Genes, Reporter; D006801:Humans; D008156:Luciferases; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
D000970:Antineoplastic Agents; D050677:Core Binding Factor Alpha 3 Subunit; C542541:MIRN106 microRNA, human; D035683:MicroRNAs; C493730:Runx3 protein, mouse; D008156:Luciferases
Gastric cancer; Multidrug resistance; Runt-related transcription factor 3; miR-106a