Synthesis, antimicrobial evaluation and QSAR studies of p-hydroxy benzoic acid derivatives.
In the present study, a series of p-hydroxy benzoic acid derivatives (1-29) was synthesized and tested for its antimicrobial potential. Results of antimicrobial studies indicated that in general, Schiff bases were found to be more active as compared to esters and compound 14 was found to be most potent antimicrobial agent (pMICam=1.50 µM/ml). QSAR study was performed in order to understand the relationship between antimicrobial activity and changes in the molecular structures which indicated that antimicrobial activity of the synthesized compounds was governed by valence first order molecular connectivity index (1χv), Kier's alpha first order shape index (κα1), Kier's first order shape index (κ1) and Balaban topological index (J).
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
A
A
Sapra
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
P
P
Kumar
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
S
S
Kakkar
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
B
B
Narasimhan
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010226:Parabens / Q000138:chemical synthesis* / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship; D012545:Schiff Bases
D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D010226:Parabens; D012545:Schiff Bases