Salinomycin: a novel anti-cancer agent with known anti-coccidial activities.
Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Therefore, salinomycin may be considered as a promising novel anti-cancer agent despite its largely unknown mechanism of action. This review summarizes the pharmacologic effects of salinomycin and presents possible mechanisms by which salinomycin exerts its anti-tumorigenic activities. Recent advances and potential complications that might limit the utilization of salinomycin as an anti-cancer and anti-CSC agent are also presented and discussed.
Department of Pharmaceutical Sciences, North Dakota State University, 203 Sudro Hall, NDSU Dept 2665, PO Box 6050, Fargo, ND 58108-6050. erxi.wu@ndsu.edu.
Shuang
S
Zhou
Fengfei
F
Wang
Eric T
ET
Wong
Ekokobe
E
Fonkem
Tze-Chen
TC
Hsieh
Joseph M
JM
Wu
Erxi
E
Wu
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D003048:Coccidiosis / Q000188:drug therapy; D003049:Coccidiostats / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D011714:Pyrans / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity*; D000095662:Polyether Polyketides
D000970:Antineoplastic Agents; D003049:Coccidiostats; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides