Effect of oral clonidine, etoricoxib, and gabapentin as premedication on sensory and motor blocks and post operative analgesia in surgeries under subarachnoid block using bupivacaine.
Oral premedicant has better patient compliance since it avoids a potential needle prick, and hence can be considered closest to an ideal premedicant. This was a randomized prospective observational study on 120 patients after obtaining ethical committee approval and valid informed consent from patients to be part of the study. We assessed the onset and duration of both sensory and motor blocks along with postoperative analgesic requirement by the patient in terms of first dose and total dose required over the period of 24 hours. It is recommended that clonidine, etoricoxib, and gabapentin be considered as good premedicants for patients undergoing surgery under spinal anesthesia. However, more research using these drugs needs to be carried out in the field of premedication.
1Department of Anaesthesia, St Stephen's Hospital, Delhi, India 2UCMS and GTB Hospital, Delhi, India.
Akhilesh K
AK
Tiwari
Swapnil
S
Tayal
Madhur
M
Chadha
Subroto
S
Ganguly
Rajani
R
Mandhyan
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000588:Amines / Q000008:administration & dosage*; D000700:Analgesics / Q000008:administration & dosage; D000775:Anesthesia, Spinal / Q000379:methods; D002045:Bupivacaine / Q000008:administration & dosage*; D003000:Clonidine / Q000008:administration & dosage*; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage*; D000077613:Etoricoxib; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods; D010149:Postoperative Pain / Q000517:prevention & control; D011292:Premedication / Q000379:methods; D011446:Prospective Studies; D011725:Pyridines / Q000008:administration & dosage*; D013346:Subarachnoid Space; D013450:Sulfones / Q000008:administration & dosage*; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage*
D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D011725:Pyridines; D013450:Sulfones; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D003000:Clonidine; D000077613:Etoricoxib; D002045:Bupivacaine