Malignant transformation of respiratory papillomatosis in a solid-organ transplant patient: case report and literature review.
We report the case of a 77-year-old non-smoker and non-drinker with a solid-organ transplant who had malignant transformation of respiratory papillomatosis 3 years after the initial diagnosis of this benign lesion. This is the first case reported in the literature of malignant transformation of respiratory papillomatosis in a solid-organ transplant patient. Virus-associated cutaneous cancers occur more frequently and aggressively in solid-organ transplant patients. There may be a higher rate of malignant transformation of respiratory papillomatosis in immunosuppressed patients, as this is a virus-associated disease. Closer observation, airway evaluation with laryngoscopy and tracheobronchoscopy, and interval biopsies of immunosuppressed patients with respiratory papillomatosis is recommended.
Department of Surgery, Head and Neck Section, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, 19111, USA.
Roya
R
Azadarmaki
Miriam N
MN
Lango
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery / Q000821:virology; D002471:Cell Transformation, Neoplastic; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology / Q000601:surgery / Q000821:virology; D012141:Respiratory Tract Infections / Q000150:complications* / Q000473:pathology / Q000601:surgery / Q000821:virology; D012307:Risk Factors; D016896:Treatment Outcome