Scopariusic acid, a new meroditerpenoid with a unique cyclobutane ring isolated from Isodon scoparius.
Scopariusic acid (1), a new ent-clerodane-based meroditerpenoid with a unique cyclobutane ring and an unusual 1-octen-3-ol substituent, together with its biosynthetic related compound 2, were isolated from the aerial parts of Isodon scoparius. The structures of 1 and 2, including their absolute configurations, were determined by spectroscopic methods, single-crystal X-ray diffraction analysis, and chemical methods. Compound 1 showed weak cytotoxicity and moderate immunosuppressive activity.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Min
M
Zhou
Hai-Bo
HB
Zhang
Wei-Guang
WG
Wang
Ning-Bo
NB
Gong
Rui
R
Zhan
Xiao-Nian
XN
Li
Xue
X
Du
Li-Mei
LM
Li
Yan
Y
Li
Yang
Y
Lu
Jian-Xin
JX
Pu
Han-Dong
HD
Sun
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D018922:HL-60 Cells; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D037602:Isodon / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D007166:Immunosuppressive Agents; C586353:scopariusic acid