The effect of levothyroxine replacement therapy on lipid profile and oxidative stress parameters in patients with subclinical hypothyroid.
The purpose of this present study is to investigate the levels of oxidative stress parameters in patients with subclinical hypothyroidism (SH) and the effects of levothyroxine (LT4) replacement therapy on these parameters and lipid profile. At the beginning of the study blood samples were collected from the patients in order to analyse oxidative stress parameters, lipid profile and biochemical markers. After replacement therapy with LT4, in the third month, same tests were performed again. At the baseline superoxide dismutase (SOD) levels were found to be higher in SH patients, compared to the euthyroid group. After LT4 therapy, statistically significant decreases in SOD and catalase levels and increase in HDL-C levels were noticed. LT4 treatment was found to have positive effects on oxidative stress indicators and HDL-C levels.
Department of Family Medicine, Gulhane School of Medicine, Ankara, Turkey. serkanmutlu17@yahoo.com.
Serkan
S
Mutlu
Department of Family Medicine, Ağrı Military Hospital, Agri, Turkey.
Adem
A
Parlak
Department of Family Medicine, Gulhane School of Medicine, Ankara, Turkey.
Umit
U
Aydogan
Department of Endocrinology and Metabolic Diseases, Gulhane School of Medicine, Ankara, Turkey.
Aydogan
A
Aydogdu
Department of Pharmaceutical Toxicology, Gulhane School of Medicine, Ankara, Turkey.
Bugra
B
Soykut
Department of Pharmaceutical Toxicology, Gulhane School of Medicine, Ankara, Turkey.
Cemal
C
Akay
Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey.
Kenan
K
Saglam
Department of Endocrinology and Metabolic Diseases, Gulhane School of Medicine, Ankara, Turkey.
Abdullah
A
Taslipinar
D000328:Adult; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D013974:Thyroxine / Q000494:pharmacology / Q000627:therapeutic use*
D008076:Cholesterol, HDL; D008055:Lipids; D013482:Superoxide Dismutase; D013974:Thyroxine
CAT; Levothyroxine; Lipid; Oxidative stress; SOD; Subclinical hypothyroidism