Reversed phase free ion selective radiotracer extraction (RP-FISRE): a new tool to assess the dynamic stabilities of metal (-organic) complexes, for complex half-lives spanning six orders of magnitude.
This paper introduces reversed phase free ion selective radiotracer extraction (RP-FISRE) as a new tool to assess the stability of metal complexes, as illustrated by the assessment of the stability of [(177)Lu]Lu-DOTA-octreotate. To this end, the TUDelft-developed FISRE, where the released metal is column-retained and the complex eluted, was changed into RP-FISRE, where the complex is column-retained and the released metal is eluted. This change in the approach allows for studies to be performed with high stability complexes. This paper presents RP-FISRE, the strength of the radiotracer approach, and the first-ever kd data on the release of (177)Lu from [(177)Lu]Lu-DOTA-octreotate.
Delft University of Technology (TUDelft), Mekelweg 15, 2629 JB Delft, The Netherlands. Electronic address: A.J.G.M.vandermeer@tudelft.nl.
Astrid
A
van der Meer
Wouter A P
WA
Breeman
Bert
B
Wolterbeek
(177)Lu; DOTA; Kinetics; Metal (-organic) complexes; Octreotate; Stability