Associations between alcohol use, other psychosocial factors, structural factors and antiretroviral therapy (ART) adherence among South African ART recipients.
We examined whether alcohol use is associated with antiretroviral therapy (ART) adherence independently of structural and psychosocial factors among 304 male and female ART recipients in ART sites in Tshwane, South Africa. ART adherence was assessed by the CASE Adherence Index. Independent variables were demographic, structural, psycho-social, and alcohol use (AUDIT score) factors. In hierarchical multiple regression, demographic variables (Step 1) explained 4 % of variance in ART adherence (p ≤ 0.01). Variance explained increased to 16 % (p ≤ 0.001) after entering structural variables (Step 2); 19 % (p ≤ 0.001) after entering psychosocial variables (Step 3); and 24 % (p ≤ 0.001) after entering AUDIT score (Step 4). Alcohol use is independently associated with ART adherence.
Alcohol and Drug Abuse Research Unit, Medical Research Council, Private Bag X385, Pretoria, 0001, South Africa, neo.morojele@mrc.ac.za.
Neo K
NK
Morojele
Connie T
CT
Kekwaletswe
Sebenzile
S
Nkosi
D000328:Adult; D000428:Alcohol Drinking / Q000523:psychology*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005260:Female; D005523:Food Supply; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology*; D006297:Health Services Accessibility; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D011788:Quality of Life; D012737:Sex Factors; D057545:Social Stigma; D012944:Social Support; D012959:Socioeconomic Factors; D013019:South Africa; D016896:Treatment Outcome; D014505:Urban Population; D019562:Viral Load
D044966:Anti-Retroviral Agents