Therapeutic nanomedicine based on dual-intelligent functionalized gold nanoparticles for cancer imaging and therapy in vivo.
A novel strategy to construct a therapeutic system based on functionalized AuNPs which can specifically respond to tumor microenvironment was reported. In the therapeutic system, doxorubicin was conjugated to AuNPs via thiol-Au bond by using a peptide substrate, CPLGLAGG, which can be specifically cleaved by the protease. In vivo study shows that after injection of the functionalized AuNPs to the tumor-bearing mice, the over-expressed protease of MMP-2 in tumor tissue and intracellular GSH can lead to the rapid release of the anti-tumor drug (doxorubicin) from the functionalized AuNPs to inhibit tumor growth and realize fluorescently imaging simultaneously. The functionalized AuNPs with tumor-triggered drug release property can further improve the efficacy and reduce side effects significantly.
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
Wei-Hai
WH
Chen
Xiao-Ding
XD
Xu
Hui-Zhen
HZ
Jia
Qi
Q
Lei
Guo-Feng
GF
Luo
Si-Xue
SX
Cheng
Ren-Xi
RX
Zhuo
Xian-Zheng
XZ
Zhang
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D019073:HT29 Cells; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D006046:Gold; D004317:Doxorubicin; D020778:Matrix Metalloproteinase 2; C522362:Mmp2 protein, mouse
Cancer imaging; Dual-intelligent; Gold nanoparticle; Therapeutic nanomedicine