Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil.
Fifteen families with clustering of infective dermatitis associated with HTLV-1 (IDH) and/or HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) were observed among 28 families of IDH index cases, 93% of them occurring in two generations. With the exception of two mothers of children with IDH, all the mothers with HAM/TSP had at least one child with HAM/TSP. This is the first report of such clustering involving many families.
Department of Pathology, Professor Edgard Santos Teaching Hospital, Federal University of Bahia, Salvador, Bahia, Brazil; Laboratory of Experimental Pathology, Gonçalo Muniz Researcher Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
José Lucas Sena
JL
da Silva
Janeusa Rita L
JR
Primo
Maria de Fátima S P
Mde F
de Oliveira
Everton da Silva
Eda S
Batista
Otávio
O
Moreno-Carvalho
Lourdes
L
Farré
Achiléa L
AL
Bittencourt
D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003872:Dermatitis / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology* / Q000821:virology*
Clustering of HTLV-1-associated diseases; HTLV-1 associated myelopathy/tropical spastic paraparesis; HTLV-1 infection; HTLV-1 vertical transmission; Infective dermatitis associated with HTLV-1