Chemically functionalized single-walled carbon nanotube films modulate the morpho-functional and proliferative characteristics of astrocytes.
We used single-walled carbon nanotube (CNT) films to modulate the morpho-functional and proliferative characteristics of astrocytes. When plated on the CNT films of various thicknesses, astrocytes grow bigger and rounder in shape with a decrease in the immunoreactivity of glial fibrillary acidic protein along with an increase in their proliferation, changes associated with the dedifferentiation of astrocytes in culture. Thus, CNT films, as a coating material for electrodes used in brain machine interface, could reduce astrogliosis around the site of implantation.
Departments of Neurobiology and Biomedical Engineering, University of Alabama , Birmingham, Alabama 35294, United States.
Manoj K
MK
Gottipati
Josheua J
JJ
Samuelson
Irina
I
Kalinina
Elena
E
Bekyarova
Robert C
RC
Haddon
Vladimir
V
Parpura
D001253:Astrocytes / Q000737:chemistry / Q000166:cytology*; D054337:Cell Dedifferentiation; D002460:Cell Line; D049109:Cell Proliferation; D004566:Electrodes; D037742:Nanotubes, Carbon / Q000737:chemistry*
D037742:Nanotubes, Carbon