Is type 2 diabetes mellitus associated with alterations in hearing? A systematic review and meta-analysis.
OBJECTIVE
The aim of this study was to systematically and quantitatively review the available evidence on the effects of type 2 diabetes mellitus on hearing function.


METHODS
Eligible studies were identified through searches of eight different electronic databases and manual searching of references. Articles obtained were independently reviewed by two authors using predefined inclusion criteria to identify eligible studies. Meta-analysis was performed on pooled data using Cochrane's Review Manager.


RESULTS
Eighteen articles fulfilled the inclusion criteria. Hearing loss (HL) was defined by all studies as pure tone average greater than 25 dB in the worse ear. The incidence of HL ranged between 44% and 69.7% for type 2 diabetics, significantly higher than in controls (OR 1.91; 95% confidence interval 1.47-2.49). The mean PTA (pure tone audiometry) thresholds were greater in diabetics than in controls for all frequencies [test or overall effect Z = 3.68, P = 0.0002]. Auditory brainstem response (ABR) wave V latencies were also statistically significantly longer in diabetics when compared to control groups [OR 3.09, 95% CI 1.82- 4.37, P < 0.00001].


CONCLUSIONS
Type 2 diabetic patients had significantly higher incidence for at least the mild degree of HL when compared with controls. Mean PTA thresholds were greater in diabetics for all frequencies but were more clinically relevant at 6000 and 8000 Hz. Prolonged ABR wave V latencies in the diabetic group suggest retro-cochlear involvement. Age and duration of DM play important roles in the occurrence of DM-related HL.
McGill Auditory Sciences Laboratory, McGill University, Montreal, QC, Canada.
Olubunmi V
OV
Akinpelu
Mario
M
Mujica-Mota
Sam J
SJ
Daniel
D017677:Age Distribution; D000368:Aged; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000453:epidemiology*; D019317:Evidence-Based Medicine; D005260:Female; D006311:Hearing Disorders / Q000175:diagnosis / Q000453:epidemiology; D034381:Hearing Loss / Q000175:diagnosis* / Q000453:epidemiology*; D006320:Hearing Tests; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012720:Severity of Illness Index; D017678:Sex Distribution
Type 2 diabetes; hearing function; meta-analysis; systematic review