Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems.
Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3(+) head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.
Centre for Strategic Nano-Fabrication, The University of Western Australia, 35 Stirling Hwy, Crawley 6009, Australia.
Eliza
E
James
Paul K
PK
Eggers
Alan R
AR
Harvey
Sarah A
SA
Dunlop
Melinda
M
Fitzgerald
Keith A
KA
Stubbs
Colin L
CL
Raston
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D047250:Calixarenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems; D018698:Glutamic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D008823:Micelles; D015394:Molecular Structure; D016716:PC12 Cells; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010743:Phospholipids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D024483:Vitamin K 3 / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism
D000975:Antioxidants; D008823:Micelles; D010636:Phenols; D010743:Phospholipids; D017382:Reactive Oxygen Species; D013501:Surface-Active Agents; C121325:calix(4)arene; D047250:Calixarenes; D018698:Glutamic Acid; D024483:Vitamin K 3; D006861:Hydrogen Peroxide