The origins of tumor-promoting inflammation.
Inflammation is increasingly recognized as an essential component of tumor development, but the origin of tumor-associated inflammation remains largely unknown. In this issue of Cancer Cell, Pribluda and colleagues find that chronic stress initiates senescence-inflammatory response, which can promote tumorigenesis in the absence of exogenous inflammatory triggers.
HHMI and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 0651, USA.
Tanya
T
Bondar
Ruslan
R
Medzhitov
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D007249:Inflammation / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*