Inheritance of the fittest mitochondria in yeast.
Eukaryotic cells compartmentalize their biochemical processes within organelles, which have specific functions that must be maintained for overall cellular health. As the site of aerobic energy mobilization and essential biosynthetic activities, mitochondria are critical for cell survival and proliferation. Here, we describe mechanisms to control the quality and quantity of mitochondria within cells with an emphasis on findings from the budding yeast Saccharomyces cerevisiae. We also describe how mitochondrial quality and quantity control systems that operate during cell division affect lifespan and cell cycle progression.
Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Jason D
JD
Vevea
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Theresa C
TC
Swayne
Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Istvan R
IR
Boldogh
Department of Pathology and Cell Biology, Columbia University, New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. Electronic address: lap5@columbia.edu.
Liza A
LA
Pon
D000818:Animals; D060049:Asymmetric Cell Division; D001692:Biological Transport; D059447:Cell Cycle Checkpoints; D003599:Cytoskeleton / Q000502:physiology; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology
D004272:DNA, Mitochondrial; D029701:Saccharomyces cerevisiae Proteins
cell division; inheritance; lifespan; mitochondria; yeast