Imatinib mesylate: an innovation in treatment of autoimmune diseases.
Imatinib mesylate is a selective protein tyrosine kinase inhibitor, which can inhibit BCR/Abl, PDGF-R, c-KIT, c-fms, TCR/Abl, Lck, FLT-3 and MAPKs activities on various cell types. On immune system, imatinib has antiproliferative activity and immunomodulatory effects in lymphocytes, macrophages, mast cells and dendritic cells with abrogating multiple signal transduction pathways involved in pathogenesis of autoimmune diseases e.g. inhibiting IFN-γ, TNF-α, IL-1β and IL-17 pro-inflammatory cytokines and MMPs secretion. To date, the efficacy of imatinib in numerous animal model of autoimmune diseases (rheumatoid arthritis, multiple sclerosis, autoimmune diabetes and glomerulonephritis) has been demonstrated, but application of this drug in human autoimmune diseases should be tested in future clinical trials. This review provides an update on the use of tyrosine kinase inhibitor imatinib mesylate in treatment of autoimmune diseases and its related recent patents that could be developed as a novel and available therapy for the management of the autoimmunity improvement.
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran- 14155, Box: 6446, Iran.
Gholamreza
G
Azizi
Abbas
A
Mirshafiey
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy*; D001549:Benzamides / Q000494:pharmacology / Q000627:therapeutic use*; D048708:Cell Growth Processes / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D000068877:Imatinib Mesylate; D056747:Immunomodulation; D018836:Inflammation Mediators / Q000378:metabolism; D010330:Patents as Topic; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects
D001549:Benzamides; D016207:Cytokines; D018836:Inflammation Mediators; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate