Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand.
In this communication, we present the synthesis of new platinum complexes based on hydroxyquinoline ligands. We demonstrate the importance and the role of the halogen substitution as well as the chelation, which are essential structural characteristics for finding good cytotoxicities.
Departamento de Química Inorgánica (Módulo 7), Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain.
Cecilia
C
Martín Santos
Silvia
S
Cabrera
Carla
C
Ríos-Luci
José M
JM
Padrón
Isabel
I
López Solera
Adoración G
AG
Quiroga
María A
MA
Medrano
Carmen
C
Navarro-Ranninger
José
J
Alemán
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D007464:Clioquinol / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006219:Halogens / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006912:Hydroxyquinolines / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D006219:Halogens; D006912:Hydroxyquinolines; D008024:Ligands; D009944:Organoplatinum Compounds; D007464:Clioquinol