Clinical effects of sinus surgery and adjuvant therapy in cystic fibrosis patients - can chronic lung infections be postponed?
BACKGROUND
The paranasal sinuses can be a bacterial reservoir for pulmonary infections in patients with cystic fibrosis (CF) METHODOLOGY: In this prospective, non-randomised, uncontrolled, intervention cohort study, the clinical effect of sinus surgery followed by two weeks` intravenous antibiotics, 6 months` antibiotic nasal irrigations was assessed in 106 CF patients.


RESULTS
One year after sinus surgery, the prevalence of intermittently colonised patients had decreased by 38%, while the prevalence of non-colonised patients had increased by 150%. The frequency of pulmonary samples with CF pathogens was reduced after surgery. Specific IgG against P. aeruginosa decreased after six months. Additionally, the self reported symptoms of chronic rhinosinusitis and quality of life improved.


CONCLUSIONS
Combined sinus surgery and postoperative systemic and topical antibiotic treatment significantly reduced the frequency of pulmonary samples positive for CF pathogens in the first year after sinus surgery.
Department of Otorhinolaryngology, Rigshospitalet, University of Copenhagen, Denmark.
K
K
Aanaes
H K
HK
Johansen
M
M
Skov
F F
FF
Buchvald
T
T
Hjuler
T
T
Pressler
N
N
Hoiby
K G
KG
Nielsen
C
C
von Buchwald
D042402:Achromobacter / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D018893:Bronchoalveolar Lavage; D019121:Burkholderia Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D042602:Burkholderia cepacia complex / Q000302:isolation & purification; D002648:Child; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003550:Cystic Fibrosis / Q000150:complications* / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000382:microbiology / Q000601:surgery*; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D011788:Quality of Life; D012220:Rhinitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D013147:Spirometry; D011795:Surveys and Questionnaires; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents