Forensic DNA methylation profiling--potential opportunities and challenges.
Investigating the DNA sequence is the most powerful tool that can be employed in forensic genetics for the identification of an individual, or to determine specific ethnic and phenotypic characteristics. However, there are also other heritable changes in gene function or cellular phenotype which are caused by mechanisms other than differences in the DNA sequence itself. Over the last decade it has become evident that epigenetic markers can be of substantial forensic significance. The determination of possible alterations in DNA methylation patterns could aid various forensic investigations, such as differentiating monozygotic twins, identifying the tissue source or determining the age of tissue donors. This review aims to give a brief overview of the possible advantages of forensic DNA methylation profiling and sheds light on the limitations of this approach.
Department of Forensic and Analytical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK. athina.a.vidaki@kcl.ac.uk
Athina
A
Vidaki
Barbara
B
Daniel
Denise Syndercombe
DS
Court
D000375:Aging / Q000235:genetics; D001826:Body Fluids / Q000737:chemistry; D002423:Cause of Death; D018899:CpG Islands; D016172:DNA Fingerprinting / Q000379:methods; D019175:DNA Methylation; D057890:Epigenomics / Q000379:methods*; D005260:Female; D053803:Forensic Genetics / Q000379:methods*; D005819:Genetic Markers; D018392:Genomic Imprinting; D006801:Humans; D008297:Male; D010290:Parents; D014430:Twins, Monozygotic / Q000235:genetics
D005819:Genetic Markers
Age determination; Body fluid identification; Cause of death; DNA methylation; Epigenetic markers; Genetic imprinting