Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites.
Transition metal complexes allow fine tuning of DNA binding affinity and selectivity. Here we report on the nucleic acid recognition properties of a phenanthroline-based ligand coordinated to Ni(2+) or Cu(2+). The resulting complexes clearly bind to telomeric G-quadruplexes at different sites according to the nature of the bound metal ion.
Dept. of Pharmaceutical and Pharmacological Sciences, University of Padova, v. Marzolo 5, 35131 Padova, Italy.
Sara
S
Bianco
Caterina
C
Musetti
A Paul
AP
Krapcho
Manlio
M
Palumbo
Claudia
C
Sissi
D001665:Binding Sites; D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry*; D054856:G-Quadruplexes; D008024:Ligands; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D056831:Coordination Complexes; D008024:Ligands; D010618:Phenanthrolines; D028561:Transition Elements; D009532:Nickel; D015032:Zinc