Protein-mimetic, molecularly imprinted nanoparticles for selective binding of bile salt derivatives in water.
A tripropargylammonium surfactant with a methacrylate-terminated hydrophobic tail was combined with a bile salt derivative, divinyl benzene (DVB), and a photo-cross-linker above its critical micelle concentration (CMC). Surface-cross-linking with a diazide, surface-functionalization with an azido sugar derivative, and free-radical-core-cross-linking under UV irradiation yielded molecularly imprinted nanoparticles (MINPs) with template-specific binding pockets. The MINPs resemble protein receptors in size, complete water-solubility, and tailored binding sites in their hydrophobic cores. Strong and selective binding of bile salt derivatives was obtained, depending on the cross-linking density of the system.
Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, USA.
Joseph K
JK
Awino
Yan
Y
Zhao
D001647:Bile Acids and Salts / Q000737:chemistry*; D001665:Binding Sites; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D008958:Models, Molecular; D054802:Molecular Imprinting; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D001647:Bile Acids and Salts; D003432:Cross-Linking Reagents; D008823:Micelles; D013501:Surface-Active Agents; D014753:Vinyl Compounds; D014867:Water; C004985:divinyl benzene