A Pd(0)-catalyzed direct dehydrative coupling of terminal alkynes with allylic alcohols to access 1,4-enynes.
A direct dehydrative coupling of terminal alkynes with allylic alcohols catalyzed by Pd(PPh3)4 with an N,P-ligand assisted by Ti(OiPr)4 has been developed. The coupling reaction tolerates various functional groups, providing a valuable synthetic tool to access 1,4-enynes.
Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Yang-Xiong
YX
Li
Qing-Qing
QQ
Xuan
Li
L
Liu
Dong
D
Wang
Yong-Jun
YJ
Chen
Chao-Jun
CJ
Li
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003681:Dehydration; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*
D000480:Alkynes; D009942:Organometallic Compounds; D020005:Propanols; C006463:allyl alcohol; D010165:Palladium