Geno- and cyto-toxicity in free-living rodent Mus spretus exposed to simulated onshore oil spill.
This study investigated geno- and cyto-toxic damage in the free-living rodent, Mus spretus after exposure to a simulated spill of crude oil on soil. The results revealed increased mutagenicity and cytotoxicity in bone marrow cells and increased DNA damage in blood cells. Exposure to crude oil increased sperm abnormalities, with lasso-like folds being the most common. These results point to the value of this rodent in serving as a sentinel species for the monitoring and prediction of environmental hazards.
LEFT-Laboratório de Ensaios Farmacológicos e Toxicológicos, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande do Sul-FURG, Av. Itália, km 8, Campus Carreiros, Rio Grande, RS, CEP 96203-900, Brazil, f.m.r.silvajunior@gmail.com.
Flavio Manoel Rodrigues
FM
da Silva
Rita Isabel
RI
Monarca
Deodália
D
Dias
Maria
M
da Graça Ramalhinho
Maria
M
da Luz Mathias
Ana Luíza
AL
Muccillo-Baisch
D000818:Animals; D000835:Animals, Wild; D003603:Cytotoxins / Q000633:toxicity; D051379:Mice; D009152:Mutagenicity Tests; D010578:Petroleum / Q000633:toxicity*; D059392:Petroleum Pollution; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D003603:Cytotoxins; D010578:Petroleum; D014874:Water Pollutants, Chemical