Computational study of the interplay of adhesion and chemotaxis in the cell seeding of tissue engineering scaffolds with incorporated chemoattractants.
Cell migration is important in embryogenesis, metastasis and wound healing. Often, morphogenesis involves chemotactic cell movement up or down chemical gradients. We have developed a computational model of a cell suspension in the vicinity of a porous scaffold that incorporates a chemoattractant substance. In order to study the interplay of adhesion and chemotaxis on cell seeding , we developed a computational model of the system and simulated its evolution using a Metropolis Monte Carlo algorithm. We varied the chemotactic strengths of the cells in order to identify the optimal conditions for a rapid and uniform seeding.
Department of Automation and Applied Informatics, "Politehnica" University of Timisoara, Timisoara, Romania.
Andreea
A
Robu
Lacramioara
L
Stoicu-Tivadar
Adrian
A
Neagu
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology*; D002630:Chemotactic Factors / Q000494:pharmacology*; D002633:Chemotaxis / Q000187:drug effects / Q000502:physiology*; D003198:Computer Simulation; D004343:Drug Implants / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds
D002630:Chemotactic Factors; D004343:Drug Implants