Palladium-catalyzed carbenoid based N-H bond insertions: application to the synthesis of chiral α-amino esters.
A highly efficient palladium-catalyzed carbenoid based N-H bond insertion has been developed. The α-amino esters were obtained in high isolated yields. Moreover, by choosing a suitable chiral auxiliary, stereoselective Pd-catalyzed N-H insertion has been realized. The chiral α-amino esters were obtained in high yields (up to 91%) and with excellent diastereoselectivities (d.r. > 19 : 1).
School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China.
Gang
G
Liu
Jian
J
Li
Lin
L
Qiu
Li
L
Liu
Guangyang
G
Xu
Bing
B
Ma
Jiangtao
J
Sun
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000588:Amines; D004952:Esters; D009942:Organometallic Compounds; C030011:carbene; D010165:Palladium; D008697:Methane