Methods of testing pharmacological drugs effects on aging and life span in mice.
The methodology of testing antiaging drugs in laboratory mice is presented. It is based on more than 40-year-long authors' experience in the field and includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment of biomarkers of aging, life-span parameters, pathology examination, and statistical treatment of the results.
Department of Carcinogenesis and Oncogerontology, NN Petrov Research Institute of Oncology, St. Petersburg, Russia.
Vladimir N
VN
Anisimov
Irina G
IG
Popovich
Mark A
MA
Zabezhinski
D000375:Aging / Q000187:drug effects*; D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D049109:Cell Proliferation / Q000187:drug effects; D016922:Cellular Senescence / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D006031:Glycosylation / Q000187:drug effects; D008136:Longevity / Q000187:drug effects*; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects
D015415:Biomarkers