Copper-catalyzed carboarylation of alkynes via vinyl cations.
Copper-catalyzed arylation of electron rich alkynes reveals stabilized trisubstituted vinyl cation equivalents that react with pendant arene nucleophiles to form all carbon tetrasubstituted alkenes. The new process streamlines the synthesis of important medicinally relevant molecules.
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, United Kingdom, CB2 1EW.
Andrew J
AJ
Walkinshaw
Wenshu
W
Xu
Marcos G
MG
Suero
Matthew J
MJ
Gaunt
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D002412:Cations / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D014753:Vinyl Compounds / Q000737:chemistry*
D000475:Alkenes; D000480:Alkynes; D002412:Cations; D014753:Vinyl Compounds; D003300:Copper