[Anhedonia in depression].
Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major depression, schizophrenia, and other neuropsychiatric disorders. The term "anhedonia" was introduced by the French psychologist Ribot in 1896 to describe the counterpart to analgesia in his patients, for which "it was impossible to find the least pleasure". Over the last decades, the clinical definition of anhedonia has remained relatively unchanged, but recently, behavioral neurosciences have significantly changed our knowledge of reward-related processes. Now, the construct of anhedonia reflects deficits in hedonic capacity, and is closely linked to the processes of reward valuation, decision-making, anticipation, and motivation. The neural circuits underlying these reward-related mechanisms include essentially the ventral striatum and prefrontal cortical regions. Here, we review the clinical concepts, neural bases and psychopharmacological data related to the deficits of hedonia in depression. Understanding anhedonia will facilitate diagnosis and treatment management.
Inserm UMR S894, service hospitalo-universitaire, laboratoire de physiopathologie des maladies psychiatriques, centre de psychiatrie et neurosciences, université Paris Descartes, Sorbonne Paris Cité, centre hospitalier Sainte-Anne, 1, rue Cabanis, 75014 Paris, France. Electronic address: raphael.gaillard@normalesup.org.
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D059445:Anhedonia / Q000502:physiology*; D059031:Anticipation, Psychological / Q000187:drug effects / Q000502:physiology; D000928:Antidepressive Agents / Q000627:therapeutic use; D001479:Basal Ganglia / Q000187:drug effects / Q000503:physiopathology; D003657:Decision Making / Q000187:drug effects / Q000502:physiology; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D009042:Motivation / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000378:metabolism; D017397:Prefrontal Cortex / Q000187:drug effects / Q000503:physiopathology; D012201:Reward
D000928:Antidepressive Agents; D018377:Neurotransmitter Agents
Anhedonia; Anhédonie; Circuit de récompense; Dépression majeure; Loss of pleasure; Major depressive disorder; Motivation; Perte de plaisir; Reward neural network