[Effect of glyphosate on the energy exchange in carp organs].
The use of glyphosate as a herbicide in agriculture can lead to the presence of its residues and metabolites (aminomethylphosphonic acid) in food for human consumption and pose a threat to health. The effect of these herbicides on the fish organism at the biochemical level has been insufficiently studied. We studied changes in the content of adenine nucleotides, enzyme activity, quantitative indexes of energy metabolism substrates in carp under the action of glyphosate. It has been found that proteins are the major energy substrate under the influence of glyphosate in the liver, brain, white muscle of carp yearlings. Glyphosphate decreases energy metabolism in the brain of carp and increases it in the white muscles. The growth of activity of catabolic enzymes in the liver under the influence of glyphosate can be attributed to the adaptive remodelling of metabolic pathways for homeostasis and enantiostasis in response to herbicides.
A A
AA
Zhidenko
E V
EV
Bibchuk
E V
EV
Barbukho
D000220:Adaptation, Biological / Q000187:drug effects; D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002347:Carps / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D029941:Fish Proteins / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000037:antagonists & inhibitors / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives* / Q000633:toxicity; D006003:Glycogen / Q000378:metabolism; D006540:Herbicides / Q000633:toxicity*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D000097797:Glyphosate
D000227:Adenine Nucleotides; D029941:Fish Proteins; D005947:Glucose; D005952:Glucose-6-Phosphatase; D005954:Glucosephosphate Dehydrogenase; D005998:Glycine; D006003:Glycogen; D006540:Herbicides; D007521:Isocitrate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D000097797:Glyphosate; C039355:isocitrate dehydrogenase (NADP+)