Quantitative online isolation of ⁶⁸Ge from ⁶⁸Ge/⁶⁸Ga generator eluates for purification and immediate quality control of breakthrough.
The breakthrough of ⁶⁸Ge from a ⁶⁸Ge/⁶⁸Ga-generator is one of the most sensitive parameters in the context of the clinical application of ⁶⁸Ga-radiopharmaceuticals. The difficulty in its determination lies in the "spectroscopic invisibility" of ⁶⁸Ge within an excess of ⁶⁸Ga. The introduced method for determining the ⁶⁸Ge content of the ⁶⁸Ge/⁶⁸Ga-generator eluate involves the quantitative separation of ⁶⁸Ga from ⁶⁸Ge, using a cation-exchanger. The eluate contains ⁶⁸Ga free of ⁶⁸Ge, which can be determined immediately, i.e. prior to the application of the ⁶⁸Ga-radiopharmaceutical.
Institute of Nuclear Chemistry, University of Mainz, D-55128 Mainz, Germany.
Elisabeth
E
Eppard
Natalia S
NS
Loktionova
Frank
F
Rösch
D005710:Gallium Radioisotopes / Q000302:isolation & purification*; D005857:Germanium / Q000302:isolation & purification*; D006801:Humans; D007474:Ion Exchange; D011786:Quality Control; D011868:Radioisotopes / Q000302:isolation & purification*; D011876:Radionuclide Generators / Q000592:standards; D019275:Radiopharmaceuticals / Q000302:isolation & purification
D005710:Gallium Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D005857:Germanium
Breakthrough; Ga-68; Ge-68; Generator; Separation