Nanomedicine for treating spinal cord injury.
Spinal cord injury results in significant mortality and morbidity, lifestyle changes, and difficult rehabilitation. Treatment of spinal cord injury is challenging because the spinal cord is both complex to treat acutely and difficult to regenerate. Nanomaterials can be used to provide effective treatments; their unique properties can facilitate drug delivery to the injury site, enact as neuroprotective agents, or provide platforms to stimulate regrowth of damaged tissues. We review recent uses of nanomaterials including nanowires, micelles, nanoparticles, liposomes, and carbon-based nanomaterials for neuroprotection in the acute phase. We also review the design and neural regenerative application of electrospun scaffolds, conduits, and self-assembling peptide scaffolds.
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. jcheng@purdue.edu.
Jacqueline Y
JY
Tyler
Xiao-Ming
XM
Xu
Ji-Xin
JX
Cheng
D000818:Animals; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000627:therapeutic use; D008823:Micelles; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D053770:Nanowires / Q000737:chemistry / Q000627:therapeutic use; D009416:Nerve Regeneration; D010455:Peptides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013119:Spinal Cord Injuries / Q000188:drug therapy / Q000628:therapy*
D008081:Liposomes; D008823:Micelles; D010455:Peptides; D011108:Polymers