Phenanthridine synthesis through iron-catalyzed intramolecular N-arylation of O-acetyl oxime.
O-Acetyl oximes derived from 2'-arylacetophenones undergo N-O bond cleavage/intramolecular N-arylation in the presence of a catalytic amount of iron(III) acetylacetonate in acetic acid. In combination with the conventional cross-coupling or directed C-H arylation, the reaction offers a convenient route to substituted phenanthridines.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Indubhusan
I
Deb
Naohiko
N
Yoshikai
D002384:Catalysis; D005290:Ferric Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry
D005290:Ferric Compounds; D010091:Oximes; D010617:Phenanthridines; D007501:Iron