Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: a serological study.
Serological surveillance conducted in areas of an outbreak of influenza A(H7N9) infection in China found no seropositivity for antibodies specific for avian-origin influenza A(H7N9) among 1129 individuals of the general population, whereas >6% of 396 poultry workers were positive (on the basis of a hemagglutination inhibition titer of ≥ 80) for this subtype, confirming that infected poultry is the principal source of human infections and that subclinical infections are possible. Fourteen days after symptom onset, elevated levels of antibodies to A(H7N9) were found in 65.8% of patients (25/38) who survived but in only 28.6% of those (2/7) who died, suggesting that the presence of antibodies may improve clinical outcome in infected patients.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University.
Shigui
S
Yang
Yu
Y
Chen
Dawei
D
Cui
Hangping
H
Yao
Jianzhou
J
Lou
Zhaoxia
Z
Huo
Guoliang
G
Xie
Fei
F
Yu
Shufa
S
Zheng
Yida
Y
Yang
Yixin
Y
Zhu
Xiaoqing
X
Lu
Xiaoli
X
Liu
Siu-Ying
SY
Lau
Jasper Fuk-Woo
JF
Chan
Kelvin Kai-Wang
KK
To
Kwok-Yung
KY
Yuen
Honglin
H
Chen
Lanjuan
L
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D064766:Influenza A Virus, H7N9 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D016036:Seroepidemiologic Studies; D016019:Survival Analysis; D055815:Young Adult
D000914:Antibodies, Viral
H1N1; H7N9; antibodies; influenza; poultry workers; serological surveillance