PREEParing for mitosis.
Reporting in Developmental Cell, Schlaitz et al. (2013) show that endoplasmic reticulum (ER) membrane exclusion from the mitotic spindle is an active process requiring REEP membrane proteins. REEP protein depletion results in ER membrane retention on the spindle and chromosomes, leading to defects in chromosome segregation and nuclear envelope assembly.
Institute of Medical Biology, 8A Biomedical Grove, Immunos, Singapore. brian.burke@imb.a-star.edu.sg
Brian
B
Burke
D002843:Chromatin / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000502:physiology*; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D008677:Metaphase / Q000502:physiology*; D009685:Nuclear Envelope / Q000502:physiology*
D002843:Chromatin; D026901:Membrane Transport Proteins; C520578:REEP3 protein, human