Evidence for therapeutic intervention in the prevention of cerebral palsy: hope from animal model research.
Knowledge translation, as defined by the Canadian Institute of Health Research, is defined as the exchange, synthesis, and ethically sound application of knowledge--within a complex system of interactions among researchers and users--to accelerate the capture of the benefits of research through improved health, more effective services and products, and a strengthened healthcare system. The requirement for this to occur lies in the ability to continue to determine mechanistic actions at the molecular level, to understand how they fit at the in vitro and in vivo levels, and for disease states, to determine their safety, efficacy, and long-term potential at the preclinical animal model level. In this regard, particularly as it relates to long-term disabilities such as cerebral palsy that begin in utero, but only express their full effect in adulthood, animal models must be used to understand and rapidly evaluate mechanisms of injury and therapeutic interventions. In this review, we hope to provide the reader with a background of animal data upon which therapeutic interventions for the prevention and treatment of cerebral palsy, benefit this community, and increasingly do so in the future.
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Antoinette
A
Nguyen
Edward A
EA
Armstrong
Jerome Y
JY
Yager
D000818:Animals; D002547:Cerebral Palsy / Q000188:drug therapy* / Q000517:prevention & control* / Q000534:rehabilitation; D003131:Combined Modality Therapy / Q000379:methods; D004195:Disease Models, Animal; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000517:prevention & control / Q000534:rehabilitation; D018696:Neuroprotective Agents / Q000627:therapeutic use*
D018696:Neuroprotective Agents