Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: a pilot study.
Sirtuin1 (SIRT1) is activated during calorie restriction and appears to be related to energy balance through glucose or lipid metabolism and insulin signaling. These findings suggest that SIRT1 may play a role in the pathophysiology of visceral obesity. Therefore, we investigated the relationship between SIRT1 gene expression in circulating peripheral blood mononuclear cells (PBMCs) and abdominal visceral adiposity as measured by computed tomography. We recruited 43 men and women without history of diabetes or cardiovascular disease Biomarkers of metabolic disease and body composition by computed tomography were assessed. SIRT1 gene expression was determined using isolated PBMCs. SIRT1 expression levels negatively correlated with body mass index, waist circumference, abdominal visceral fat area, and homeostasis model of assessment of insulin resistance (HOMA-IR) and positively correlated with adiponectin levels. Results of step-wise multiple regression analysis revealed that abdominal visceral fat area and HOMA-IR were independently associated with SIRT1 expression. The significant association between abdominal visceral fat accumulation and SIRT1 gene expression in PBMCs suggests that SIRT1 may be a new therapeutic target for the prevention of disease related to obesity, especially visceral obesity.
Department of Clinical Nursing Science, Yonsei University College of Nursing, Nursing Policy and Research Institute, Biobehavioral Research Center, Seoul 120-752, Korea.
Hyangkyu
H
Lee
Sang Hui
SH
Chu
Jae Yeo
JY
Park
Hyun Ki
HK
Park
Jee Aee
JA
Im
Ji Won
JW
Lee
D052242:Adiponectin / Q000097:blood; D050154:Adiposity / Q000235:genetics*; D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D015870:Gene Expression; D064368:Healthy Volunteers; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D010865:Pilot Projects; D012333:RNA, Messenger / Q000378:metabolism; D012044:Regression Analysis; D056564:Sirtuin 1 / Q000235:genetics* / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D055105:Waist Circumference
D052242:Adiponectin; D012333:RNA, Messenger; C447939:SIRT1 protein, human; D056564:Sirtuin 1