Incidence of intraoperative hypotension during isoflurane-fentanyl and propofol-fentanyl anaesthesia in dogs.
Most anaesthetic and analgesic drugs affect the cardiovascular system and can cause intraoperative hypotension (IOH). This study aimed to compare the incidence of IOH in anaesthetised dogs when isoflurane-fentanyl was used, compared to propofol-fentanyl. Intraoperative hypotension was defined as an episode of mean blood pressure below 60 mmHg for more than 5 min during anaesthesia. The incidence of IOH was 65.3% for isoflurane-fentanyl and 27.6% for propofol-fentanyl. The adjusted odds ratio for IOH when propofol-fentanyl was compared to isoflurane-fentanyl was 0.2 (95% CI 0.11-0.38). These results suggest that propofol-fentanyl is associated with a lower risk of IOH than isoflurane-fentanyl anaesthesia.
Laboratory of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Tomoya
T
Iizuka
Masatoshi
M
Kamata
Masashi
M
Yanagawa
Ryohei
R
Nishimura
D000701:Analgesics, Opioid / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced / Q000453:epidemiology*; D004285:Dogs; D005260:Female; D005283:Fentanyl / Q000009:adverse effects; D007022:Hypotension / Q000139:chemically induced / Q000453:epidemiology / Q000662:veterinary*; D015994:Incidence; D007431:Intraoperative Complications / Q000139:chemically induced / Q000453:epidemiology / Q000662:veterinary*; D007530:Isoflurane / Q000009:adverse effects; D008297:Male; D015742:Propofol / Q000009:adverse effects; D014041:Tokyo / Q000453:epidemiology
D000701:Analgesics, Opioid; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007530:Isoflurane; D005283:Fentanyl; D015742:Propofol
Dogs; Fentanyl; Intraoperative hypotension; Isoflurane; Propofol