[Pharmaceutical applications of sulfobuthylether-beta-cyclodextrin].
Sulfobuthylether-beta-cyclodextrin (SBECD) is a substituted derivative of a cyclic oligosaccharide containing seven glucopyranose units, which bear pH-independent negative charges because of sulfonate groups. This derivative has better solubility and toxicological characteristics than the unsubstituted beta-cyclodextrin, and the presence of sulfobuthyl groups opens new dimensions in the interactions acting the part of the complex formation. These create opportunities for the pharmaceutical applications of this compound. Currently six pharmaceutical preparations circulate--moiety of these circulates in Hungary also--which have a composition containing SBECD as pharmaceutical excipient. Out of the main effects of the complex-forming agent the solubility enhancement is utilized in these compositions to achieve the solution of a therapeutic dose in the case of intravascular administration. Available experimental evidences and published patents are indicative of broadening the circle of the applications in point of both technological advantages and dosage forms.
Gyógyszerészeti Intézet, Semmelweis Egyetem, 1092 Budapest, Hogyes E. u. 7. sebestyen.zita@pharma.semmelweis-univ.hu
Zita
Z
Sebestyén
Katalin
K
Szepesi
Barnabás
B
Szabó
D000638:Amiodarone / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D000932:Antiemetics / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D000068180:Aripiprazole; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004355:Drug Stability; D006801:Humans; D006814:Hungary; D009101:Multiple Myeloma / Q000188:drug therapy; D009842:Oligopeptides / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology; D012995:Solubility; D013844:Thiazoles / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D000932:Antiemetics; D000935:Antifungal Agents; D014150:Antipsychotic Agents; D004304:Dosage Forms; D009842:Oligopeptides; D010879:Piperazines; D011743:Pyrimidines; D015363:Quinolones; D011812:Quinuclidines; D013844:Thiazoles; D014230:Triazoles; D047392:beta-Cyclodextrins; C093196:SBE4-beta-cyclodextrin; C518176:maropitant; C092292:ziprasidone; C524865:carfilzomib; D000068180:Aripiprazole; D065819:Voriconazole; D000638:Amiodarone