Modelling amyloid fibril formation kinetics: mechanisms of nucleation and growth.
Amyloid and amyloid-like fibrils are self-assembling protein nanostructures, of interest for their robust material properties and inherent biological compatibility as well as their putative role in a number of debilitating mammalian disorders. Understanding fibril formation is essential to the development of strategies to control, manipulate or prevent fibril growth. As such, this area of research has attracted significant attention over the last half century. This review describes a number of different models that have been formulated to describe the kinetics of fibril assembly. We describe the macroscopic implications of mechanisms in which secondary processes such as secondary nucleation, fragmentation or branching dominate the assembly pathway, compared to mechanisms dominated by the influence of primary nucleation. We further describe how experimental data can be analysed with respect to the predictions of kinetic models.
School of Physics and Astronomy, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JZ, UK.
J E
JE
Gillam
C E
CE
MacPhee
D000682:Amyloid / Q000737:chemistry*; D000818:Animals; D055162:Biocatalysis; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D055503:Protein Multimerization
D000682:Amyloid