A personal view of skin permeation (1960-2013).
I want to thank Mike Roberts for arranging this issue of the journal and Annette Bunge and Richard Guy for reviewing this paper. This is, first, a history of my introduction to the field of skin permeability, and then an attempt to recall (with the inaccuracies that implies) the highlights of my research (1960-1975) on skin permeation, and finally a reflection by an old-timer on more recent concepts.
Keller and Heckman LLP, Washington, DC 20001, USA. scheuplein@khlaw.com
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D000279:Administration, Cutaneous; D035843:Biomedical Research / Q000266:history; D016503:Drug Delivery Systems; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D018570:Risk Assessment / Q000379:methods; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption