Small intestinal cancers among adults in an Egyptian district: a clinicopathological study using a population-based cancer registry.
BACKGROUND
Small intestinal cancers (SICs) are very rare all over the world and little is known about them in Egypt.


METHODS
This a retrospective study. Between 2000 and 2002, 30 cases with SICs were identified in the Gharbiah population based cancer registry (GPBCR); 17 cases of whom were treated at Tanta Cancer Center (TCC).


RESULTS
The median age was 51 years with female predominance. The duodenum was the commonest site (43%) followed by the ileum then the jejunum. Adenocarcinoma (AC), carcinoids, gastrointestinal stromal tumors (GISTs), lymphoma and sarcoma represented 50%, 10%, 17%, 13% and 10% respectively. Abdominal pain was the commonest symptom and localized disease was the commonest presentation. Surgery, chemotherapy and radiotherapy were employed in 65%, 35% and 0% of patients, respectively. The median overall survival and progression free survival (OS, PFS) were 18 and 15 months (95% CI: 10.4-25.6 and 3.6-26.4), respectively. AC had inferior OS and PFS to other histologies (p = 0.08 and 0.12, respectively). Also, duodenum subsite was inferior in OS and PFS to other sites (p = 0.25 and 0.35, respectively).


CONCLUSIONS
SICs in Gharbiah, Egypt are characterized by predominance of female gender and adenocarcinoma histology. One year survival is 64% with a poor outcome for adenocarcinoma and duodenal subsite.
Medical Oncology/Hematology Department, National Cancer Institute, Cairo University, Cairo, Egypt. azeeneldin@gmail.com
Ahmed A
AA
Zeeneldin
Magdy M
MM
Saber
Ibrahim A
IA
Seif El-Din
Sara A
SA
Frag
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D000328:Adult; D000368:Aged; D004379:Duodenal Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D007421:Intestine, Small / Q000473:pathology; D007580:Jejunal Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D055815:Young Adult
Egypt; Gharbiah population-based cancer registry; Small intestinal neoplasms; Survival; Treatment