A blend of phellodendron and crape myrtle improves glucose tolerance in exercise-trained men.
BACKGROUND
The purpose of this study was to investigate the acute effects of a nutritional supplement containing a proprietary blend of Phellodendron and Crape Myrtle on serum glucose and insulin in response to a modified oral glucose tolerance test (OGTT).


METHODS
Using a randomized, double-blind, cross-over design, 10 exercise-trained, non-diabetic men reported to the lab in a 10 hour fasted state, on two different mornings separated by 1-2 weeks, and were subjected to an OGTT by ingesting a 75 gram dextrose solution. Fifteen minutes prior to the OGTT subjects ingested either a dietary supplement containing a blend of Phellodendron and Crape Myrtle (SUPP) or a placebo (PLA). Blood samples were collected before ingestion of the SUPP or PLA and at 15, 30, 45, 60, and 75 minutes post-ingestion of the dextrose load. Samples were analyzed for serum glucose and insulin.


RESULTS
In relation to serum glucose, a condition effect was noted (P = 0.01), with values lower for SUPP compared to PLA. In relation to serum insulin, a trend for a condition effect was noted (P = 0.06), with values lower for SUPP compared to PLA.


CONCLUSIONS
These findings indicate that acute ingestion of a dietary supplement containing a blend of Phellodendron and Crape Myrtle can lower the serum glucose response to a modified OGTT, while resulting in a non-significant attenuation in insulin response. These data are specific to a small sample of exercise-trained, non-diabetic men.
Cardiorespiratory and Metabolic Laboratory, The University of Memphis, Memphis, TN 38152, USA.
Robert E
RE
Canale
Tyler M
TM
Farney
Cameron G
CG
McCarthy
Richard J
RJ
Bloomer
Crape Myrtle; Phellodendron; dietary supplements; glucose; insulin resistance