Diverging role for coronin 1 in antiviral CD4+ and CD8+ T cell responses.
Coronin 1 is a member of the evolutionary conserved WD repeat protein family and is highly expressed in hematopoietic cells. Coronin 1 is essential for Ca(2+) mobilization upon T cell receptor (TCR) stimulation providing a pro-survival signal for naïve peripheral T cells. Both in mouse and in human, coronin 1 deficiency is associated with severe T cell lymphopenia. In this work, we have analyzed antiviral T cell-mediated immunity in the presence and absence of coronin 1 in vivo after infection with lymphocytic choriomenigitis virus (LCMV) and vesicular stomatitis virus (VSV) in mice. Despite low peripheral T cell numbers we found that LCMV-specific CD8(+) T cell responses were normal in the absence of coronin 1 and kinetics of LCMV-clearance were similar compared to wild type mice. In contrast, CD4(+) T cell responses were profoundly decreased after LCMV- and VSV-infection. We propose that coronin 1 plays a differential role in CD8(+) versus CD4(+) T cell responses and activation.
Biozentrum, University of Basel, Switzerland; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland. Electronic address: Vincent.Tchang@unibas.ch.
Vincent Sam Yong
VS
Tchang
Andrea
A
Mekker
Kerstin
K
Siegmund
Urs
U
Karrer
Jean
J
Pieters
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D054884:Host-Pathogen Interactions / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology / Q000502:physiology; D008231:Lymphopenia / Q000235:genetics / Q000276:immunology / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008840:Microfilament Proteins / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D012327:RNA Virus Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D016019:Survival Analysis; D013997:Time Factors; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology / Q000502:physiology
D008840:Microfilament Proteins; C072061:coronin proteins
Coronin 1; DTH; LCMV; PFU; T cells; VSV; Viral infection; delayed type hypersensitivity; lymphocytic choriomeningitis virus; plaque forming unit; vesicular stomatitis virus