Mortality after in-hospital cardiopulmonary resuscitation: multicenter analysis in Korea.
OBJECTIVE
The purpose of this study is to evaluate factors associated with the mortality of patients admitted to intensive care units (ICUs) after in-hospital cardiopulmonary resuscitation (CPR) and the impact of a hospital rapid response system (RRS) on patient mortality in Korea.


METHODS
A prospective multicenter cohort study was done in 22 ICUs of 15 centers from July 1, 2010, to January 31, 2011. We only enrolled patients admitted to ICUs after in-hospital CPR and divided eligible patients into 2 groups-survivors and nonsurvivors.


RESULTS
Among 4617 patients, 150 patients were admitted post-CPR, 76 died, and 74 survived. At 24 hours, the Sequential Organ Failure Assessment score, Simplified Acute Physiology Score II, and the best Glasgow Coma Scale were significantly lower in the nonsurvivors than in the survivors. In multivariate analysis, the Simplified Acute Physiology Score II and presence of lower respiratory infection were both independently associated with mortality. At the first hour after admission, lowest serum potassium and highest heart rate were associated with mortality. At 24 hours after admission, lowest mean arterial pressure, HCO3 level, and venous oxygen saturation level; highest heart rate; and use of vasoactive drugs were associated with mortality. The mortality of patients in hospitals with an RRS was not significantly different from that of hospitals without an RRS.


CONCLUSIONS
Various physiologic and laboratory parameters were associated with the mortality of post-CPR ICU admitted patients, and the presence of an RRS did not reduce mortality of these patients in our study.
Department of Medicine, Division of Pulmonary and Critical Care Medicine, College of Medicine, Gyeongsang Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Ho Cheol
HC
Kim
Jun-Wan
JW
Yoo
So Yeon
SY
Lim
Gee Young
GY
Suh
Shin Ok
SO
Koh
Sungwon
S
Na
Chae-Man
CM
Lim
Younsuck
Y
Koh
Won-Il
WI
Choi
Young-Joo
YJ
Lee
Seok Chan
SC
Kim
Chin Kook
CK
Rhee
Gyu Rak
GR
Chon
Je Hyeong
JH
Kim
Jae Yeol
JY
Kim
Jaemin
J
Lim
Sunghoon
S
Park
Jin Hwa
JH
Lee
Ji Hyun
JH
Lee
D015415:Biomarkers / Q000032:analysis; D016887:Cardiopulmonary Resuscitation / Q000401:mortality*; D016638:Critical Illness / Q000401:mortality*; D005260:Female; D006305:Health Status Indicators; D006323:Heart Arrest / Q000401:mortality* / Q000628:therapy*; D017052:Hospital Mortality; D057209:Hospital Rapid Response Team / Q000458:organization & administration; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D015996:Survival Rate
D015415:Biomarkers
Cardiopulmonary resuscitation; Mortality; Parameters; Rapid response system