Water-soluble Tb3+ and Eu3+ complexes with ionophilic (ionically tagged) ligands as fluorescence imaging probes.
This article describes a straightforward and simple synthesis of ionically tagged water-soluble Eu(3+) and Tb(3+) complexes (with ionophilic ligands) applied for bioimaging of invasive mammal cancer cells (MDA-MB-231). Use of the task-specific ionic liquid 1-methyl-3-carboxymethyl-imidazolium chloride (MAI·Cl) as the ionophilic ligand (ionically tagged) proved to be a simple, elegant, and efficient strategy to obtain highly fluorescent water-soluble Eu(3+) (EuMAI) and Tb(3+) (TbMAI) complexes. TbMAI showed an intense bright green fluorescence emission selectively staining endoplasmic reticulum of MDA-MB-231 cells.
Laboratory of Medicinal and Technological Chemistry, University of Brasilia (IQ-UnB), Campus Universitário Darcy Ribeiro, CEP 70904970, P.O. Box 4478, Brasilia-DF, Brazil.
Julia R
JR
Diniz
José R
JR
Correa
Daniel de A
Dde A
Moreira
Rafaela S
RS
Fontenele
Aline L
AL
de Oliveira
Patrícia V
PV
Abdelnur
José D L
JD
Dutra
Ricardo O
RO
Freire
Marcelo O
MO
Rodrigues
Brenno A D
BA
Neto