E. coli and colon cancer: is mutY a culprit?
The recent demonstration of a role of Escherichia coli in the development of invasive carcinoma in mice ushers a new era of bacterial involvement in cancer etiology. It has been shown previously that the colonic mucosa of colorectal carcinoma (CRC) is exclusively colonized by intracellular E. coli instead of extracellular form found in normal colonic mucosa. Surprisingly, the DNA repair gene MUTYH, which is a homologue of the E. coli gene mutY, is responsible for CRC. The current paper discusses the potential role of mutY in CRC etiology and concludes that research in this area can bring together the diverse threads of the CRC etiology puzzle.
Department of Microbiology, College of Life Sciences, Cancer Hospital & Research Institute, Gwalior, MP, India; Department of Pharmaceutics, College of Pharmacy, PO Box 2457, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: abdularifkhan@gmail.com.
Abdul Arif
AA
Khan
Phillip
P
Cash
D000818:Animals; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D045647:DNA Glycosylases / Q000235:genetics* / Q000378:metabolism; D004260:DNA Repair / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics* / Q000502:physiology; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000235:genetics; D007413:Intestinal Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008957:Models, Genetic
D029968:Escherichia coli Proteins; D045647:DNA Glycosylases; C061738:mutY adenine glycosylase
Carcinogenesis; Chronic inflammation; E. coli; MUTYH; mutY