[Pharmacological characteristics of ertapenem].
Ertapenem is a broad-spectrum bactericidal carbapenem antibiotic. It differs from the other substances of this group by the absence of action against Gram-negative non-fermenting bacilli and by a long elimination half-life, which allows once-daily administration. It is administered once daily in a dose of 1 gram intravenously. Ertapenem is generally well-tolerated, with the most common side effects being diarrhea and phlebitis at the injection site. It is used for the treatment of community-acquired pneumonia, intra-abdominal and gynecological infections, and skin and soft tissue infections, including diabetic foot.
Department of Pharmacology, Faculty of Medicine and Dentistry, Palacký University in Olomouc, Czech Republic. urbanek@fnol.cz
Karel
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Urbánek
Hana
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Suchánková
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D000077727:Ertapenem; D006801:Humans; D047090:beta-Lactams / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D000077727:Ertapenem